WorldWideScience

Sample records for bright gm mendoza

  1. Mendoza : Rahvuslike huvide eiramine toob Euroliidule kollapsi / Alan Mendoza ; interv. Indrek Veiserik

    Index Scriptorium Estoniae

    Mendoza, Alan

    2008-01-01

    Intervjuu Henry Jacksoni Ühingu presidendiga, kes vastab küsimustele, mis puudutavad NATO laienemist, Lissaboni lepet, Euroopa Liidu kaitse- ja välispoliitikat, Eesti välispoliitikat ja suhteid Venemaaga. Vt. samas: Alan Mendoza ja Henry Jacksoni ühing

  2. GM Crops: Patently Wrong?

    OpenAIRE

    Wilson, J.

    2007-01-01

    Abstract This paper focuses on the ethical justifiability of patents on Genetically Modified (GM) crops. I argue that there are three distinguishing features of GM crops that make it unethical to grant patents on GM crops, even if we assume that the patent system is in general justified. The first half of the paper critiques David Resnik’s recent arguments in favor of patents on GM crops. Resnik argues that we should take a consequentialist approach to the issue, and that the best way to do s...

  3. Payenia volcanic province, southern Mendoza, Argentina

    DEFF Research Database (Denmark)

    Søager, Nina; Holm, Paul Martin; Llambias, Eduardo Jorge

    2013-01-01

    to the low thickness of the lithospheric mantle and preheating of the lower crust by earlier Mio-Pliocene volcanism. Rare earth element modelling of mantle melting calls for enriched source compositions and a beginning of melting within the garnet stability field for all Payenia basalts. The Río Colorado......The Pleistocene to Holocene Payenia volcanic province is a backarc region of 60,000 km2 in Mendoza, Argentina, which is dominated by transitional to alkaline basalts and trachybasalts. We present major and trace element compositions of 139 rocks from this area of which the majority are basaltic...... rocks with 4 to 12 wt.% MgO and 44 to 50 wt.% SiO2. The southern Payenia province is dominated by intraplate basalts and the trace element patterns of the Río Colorado and Payún Matrú lavas suggest little or no influence from subducted slab components. The mantle source of these rocks is similar to some...

  4. Will GM animals follow the GM plant fate?

    OpenAIRE

    Vàzquez-Salat, Núria; Houdebine, Louis-Marie

    2013-01-01

    Despite being both Genetically Modified Organisms (GMOs), GM plants and GM animals share few similarities outside the laboratory premises. Whilst GM plants were soon embraced by industry and became a commercial success, only recently have GM animals reached the market. However, an area where GM animals are likely to follow the GM plant path is on their potential to cause social unrest. One of the major flaws of the 90s GMO crisis was the underestimation of the influence that different players...

  5. GM Risk Assessment

    Science.gov (United States)

    Sparrow, Penny A. C.

    GM risk assessments play an important role in the decision-making process surrounding the regulation, notification and permission to handle Genetically Modified Organisms (GMOs). Ultimately the role of a GM risk assessment will be to ensure the safe handling and containment of the GMO; and to assess any potential impacts on the environment and human health. A risk assessment should answer all ‘what if’ scenarios, based on scientific evidence.

  6. El volcanismo del Terciario superior del sur de Mendoza Upper Terciary volcanism from southern Mendoza

    Directory of Open Access Journals (Sweden)

    F. E. Nullo

    2002-06-01

    Full Text Available Se describe por primera vez la petrografía y geoquímica de unidades volcánicas terciarias del sur de la provincia de Mendoza. Se analizan la nomenclatura estratigráfica y sus edades, estableciéndose una secuencia de eventos magmáticos ocurridos durante el Neógeno, comenzando con la evolución de un retro-arco, seguido por un arco magmático más joven. Se intenta respetar la nomenclatura estratigráfica existente, sin embargo, la definición de unidades se ha realizado sobre la base de las edades radimétricas y sus edades de cristalización, más sobre sus características petrográficas. La actividad magmática se extiende desde el Oligoceno superior al Mioceno superior, correspondiendo a el Ciclo Eruptivo Molle y el Ciclo Eruptivo Huincán, y comenzó con un episodio magmático basáltico inicial (CEM. Esta actividad se generó en la corteza inferior dominada por la concentración de gabros, dioritas y rocas híbridas (granulitas máficas. Debido a un engrosamiento de la corteza como consecuencia de la actividad tectónica durante Mioceno superior o por el estancamiento de magmas o por la combinación de ambos procesos, la formación de granulitas granatíferas resultó un producto distintivo de la corteza inferior. Con el desarrollo del arco magmático (CEH en el Mioceno superior, los magmas ascendieron desde la fuente mantélica, encontrándose con una corteza inferior granatífera, perdiendo capacidad de ascenso por falta de contraste de densidades, produciéndose una fusión extendida, la homogeinización y el ascenso, en equilibrio con la corteza baja, proceso que caracteriza el volcanismo de un arco magmático.The petrology and geochemistry of the exposed Tertiary volcanic units in southern Mendoza Province are described for the first time. The formal stratigraphic nomenclature and ages are analyzed and a stratigraphic basis is established for successive magmatic events occurring during the Neogene, starting with the evolution of

  7. Improvement on GM models

    Institute of Scientific and Technical Information of China (English)

    党耀国; 刘思峰; 刘斌

    2004-01-01

    Since grey system theory was established by prof. Deng, GM models and their improvements have all taken the first vector of the original sequence as the initialization, which resulted to deficiency in making use of the latest infor-mation. Based on the principle, which new information should be used fully, we think it is scientific to pay more atten-tion to the new information or endow them a more weigh. So, this paper deals with the GM improvement by taking the n-th vector as the initialization, and gets great improvement in forecasting precision. Last, we validate the practicability and reliability of the moelds with examples.

  8. The Unusual Photometric Variability of the PMS Star GM Cep

    Science.gov (United States)

    Semkov, E. H.; Ibryamov, S. I.; Peneva, S. P.; Milanov, T. R.; Stoyanov, K. A.; Stateva, I. K.; Kjurkchieva, D. P.; Dimitrov, D. P.; Radeva, V. S.

    2015-03-01

    Results from UBVRI photometric observations of the pre-main sequence star GM Cep obtained in the period 2011 April-2014 August are reported in the paper. Presented data are a continuation of our photometric monitoring of the star started in 2008. GM Cep is located in the field of the young open cluster Trumpler 37 and over the past years it has been an object of intense photometric and spectral studies. The star shows a strong photometric variability interpreted as a possible outburst from EXor type in previous studies. Our photometric data for a period of over six years show a large amplitude variability (ΔV ~ 2.3 mag) and several deep minimums in brightness are observed. The analysis of the collected multicolour photometric data show the typical of UX Ori variables a colour reversal during the minimums in brightness. The observed decreases in brightness have a different shape, and evidences of periodicity are not detected. At the same time, high amplitude rapid variations in brightness typical for the classical T Tauri stars also present on the light curve of GM Cep. The spectrum of GM Cep shows the typical of classical T Tauri stars wide Hα emission line and absorption lines of some metals. We calculate the outer radius of the Hα emitting region as 10.4 ± 0.5 R⊙ and the accretion rate as 1.8 × 10- 7 M⊙ yr- 1.

  9. Governing the GM crop revolution

    OpenAIRE

    Paarlberg, Robert L.

    2000-01-01

    Will developing countries adopt policies that promote the planting of genetically modified (GM) crops, or will they select policies that slow the spread of the GM crop revolution? The evidence so far is mixed. In some prominent countries such as China, policies are in place that encourage the independent development and planting of GM crops. Yet in a number of other equally prominent countries the planting of GM crops is not yet officially approved. The inclination of developing countries to ...

  10. GM1 and GM2 gangliosides: recent developments.

    Science.gov (United States)

    Bisel, Blaine; Pavone, Francesco S; Calamai, Martino

    2014-03-01

    GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 and GM2 and their involvement in several diseases. In addition to a well-established spectrum of disorders known as gangliosidoses, such as Tay-Sachs disease, more and more evidence points at an involvement of GM1 in Alzheimer's and Parkinson's diseases. New emerging methodologies spanning from single-molecule imaging in vivo to simulations in silico have complemented standard studies based on ganglioside extraction. PMID:25372744

  11. Playing games to design GM/Non-GM coexistence scenarios

    OpenAIRE

    Le Bail, Marianne; Lecroart, Baptiste; Remy, Brigitte; Sausse, Christophe

    2009-01-01

    Coexistence is an approach allowing farmers to choose between conventional and genetically modified (GM) crops and allowing consumers to choose between different food products subject to obligations regarding labelling and purity (European Commission, 2003). Some research have already been carried out to assess the risks of cross-pollination between GM and non-GM crops at field level, and the effect of individual measures to reduce those risks (Beckie and Hall 2008). Nonetheless, the feasibil...

  12. El volcanismo del Terciario superior del sur de Mendoza

    OpenAIRE

    F.E. Nullo; G. C. Stephens; J. Otamendi; P. E. Baldauf

    2002-01-01

    Se describe por primera vez la petrografía y geoquímica de unidades volcánicas terciarias del sur de la provincia de Mendoza. Se analizan la nomenclatura estratigráfica y sus edades, estableciéndose una secuencia de eventos magmáticos ocurridos durante el Neógeno, comenzando con la evolución de un retro-arco, seguido por un arco magmático más joven. Se intenta respetar la nomenclatura estratigráfica existente, sin embargo, la definición de unidades se ha realizado sobre la base de las edades ...

  13. The Wine Clusters of Mendoza and Serra Gaúcha: A Local Development Perspective

    Directory of Open Access Journals (Sweden)

    María Verónica ALDERETE

    2014-01-01

    Full Text Available This paper consists of a descriptive analysis that explains how the successful performance of the wine cluster is followed by improvements in local development indicators. To this end, certain local development indicators are proposed to describe and compare the wine clusters of Mendoza (Argentina and Serra Gaúcha (Brazil. In Argentina, the Mendoza wine cluster has stimulated the local development of the region. For its part, Serra Gaúcha is the most successful wine center in Brazil and regards Mendoza as the benchmark in terms of local development.

  14. Epidemiology of livestock fasciolosis in Mendoza province, Argentina

    International Nuclear Information System (INIS)

    Full text: Fasciolosis, parasitic disease caused by the trematode Fasciola hepatica, affects many mammals, particularly ruminants, and is now considered an important zoonotic disease. In Mendoza province, the data from the local slaughterhouses and observations made by veterinarians indicated that fasciolosis could be an important disease in cattle with 5,7% (1) liver condemnation registered which is well over the national average that oscillates yearly around 1%. Thus, even though fasciolosis seemed to be an important disease for livestock, the epidemiological information was lacking. Since the recent identification of the most efficient vector of fasciolosis in Mendoza, the introduced lymnaeid snail Galba truncatula (2), the epidemiological situation of fasciolosis needs to be addressed. Our objective was to gain insight in the epidemiology of fasciolosis in Mendoza province. Mendoza province is in the west of Argentina. To the east is a plains region and at the west are the Andes Mountains. The rivers run from the mountains in the west towards the east traversed by valleys were livestock is managed extensively and trashumance is a common practice To investigate the distribution of the lymnaeid snails, samples where recovered following an altitudinal gradient, from the plains region at 600 m.a.s.l. up to above 3000 m.a.s.l. In each sampling point, by means of a GPS, altitude, longitude and latitude was registered, water pH, conductivity and hardness evaluated, and the environmental characteristics of the site recorded. To investigate the possible reservoirs fasciolosis coprological studies were performed (Lumbreras rapid sedimentation and Formo-ether sedimentation) and liver inspection at the slaughterhouse was recorded. Lymnaeid snails where found in 27 sites, belonging to all of the river basins of Mendoza. The range of altitude was from 649 masl to 2971 masl, (μ1674). They were found in small streams with slow current in 18 sites (66,7%) small irrigation

  15. Labelling GM-free Products

    DEFF Research Database (Denmark)

    Punt, Maarten; Venus, Thomas; Wesseler, Justus

    2016-01-01

    Food suppliers in the EU must comply with labelling regulations for genetically modified organisms (GMOs). However, excluded from mandatory labelling are food products derived from animals fed with GM feed (mainly GM soybean in the EU). Because of this labelling exemption, consumers are unable to...

  16. El palacio de don Antonio de Mendoza en Guadalajara. Aspectos decorativos y formales

    Directory of Open Access Journals (Sweden)

    Rodríguez Rebollo, Ángel

    2002-09-01

    Full Text Available The Palace of Don Antonio de Mendoza in Guadalajara was constructed at the beginning of the sixteenth century. In spite of the absence of documentation, there are clear stylistic similarities between this palace and the Calahorra Palace (Granada and the tomb of Cardinal Mendoza. The Codex Escurialensis was used for the decoration of the first floor column capitals as well as the façade decoration.

    El Palacio de Don Antonio de Mendoza en Guadalajara fue construido a principios del XVI. Pese a no estar documentado, las similitudes estilísticas con el Palacio de la Calahorra (Granada y el sepulcro del Cardenal Mendoza son claros. El Codex Excurialensis fue usado en la decoración de los capiteles del primer piso y en la decoración de la fachada principal.

  17. Can GM sorghum impact Africa?

    Science.gov (United States)

    Botha, Gerda M; Viljoen, Christopher D

    2008-02-01

    It is said that genetic modification (GM) of grain sorghum has the potential to alleviate hunger in Africa. To this end, millions of dollars have been committed to developing GM sorghum. Current developments in the genetic engineering of sorghum are similar to efforts to improve cassava and other traditional African crops, as well as rice in Asia. On closer analysis, GM sorghum is faced with the same limitations as 'Golden Rice' (GM rice) in the context of combating vitamin A deficiency (VAD) efficiently and sustainably. Thus, it is questionable whether the cost of developing GM sorghum can be justified when compared to the cost of investing in sustainable agricultural practice in Africa. PMID:18191263

  18. Property Claims in GM and Non-GM crops

    OpenAIRE

    Gill, Bernhard

    2009-01-01

    Conceptualising the ongoing conflict over GM versus non-GM crops in the frame of property rights one can see that economic valorisation dynamics and aspirations are working on both sides, within two differently evolving agri-food paradigms, with biotechnology companies propagating intellectual property rights on seeds and crops within a productivist strategy, and with retailer chains, NGOs, farmer associations claiming generic names and labels as public property rights on identity preserved c...

  19. Plant growth promoting activity of siderophore producing Enterobacter cloacae GM-11

    OpenAIRE

    Jikare A. M.; Chavan M. D.

    2013-01-01

    Siderophore producing bacteriumEnterobacter cloacae GM-11 was isolated from rhizosphere soil in Solapur region, Maharashtra. The Chrome Azurol S (CAS) assay was performed to detect the siderophore production. In CAS plate assay, the dark medium produce bright zone with yellowish fluorescent color. Arnow'sassay and Csaky'sassay were used.Check its phosphate solubilizing activity on Pikovaskaya medium.Moreover, Enterobacter cloacae GM-11 inoculate enhanced seed germination,root length and shoot...

  20. Reference: NODCON2GM [PLACE

    Lifescience Database Archive (English)

    Full Text Available NODCON2GM Sandal NN, Bojsen K, Marcker KA. A small family of nodule specific genes ...from soybean. Nucleic Acids Res. 15:1507-1519 (1987). consesus; in silico; PubMed: 3822835 ...

  1. Reference: NODCON1GM [PLACE

    Lifescience Database Archive (English)

    Full Text Available NODCON1GM Sandal NN, Bojsen K, Marcker KA. A small family of nodule specific genes ...from soybean. Nucleic Acids Res. 15:1507-1519 (1987). consesus; in silico; PubMed: 3822835 ...

  2. The unusual photometric variability of the PMS star GM Cep

    CERN Document Server

    Semkov, E; Peneva, S; Milanov, T; Stoyanov, K; Stateva, I; Kjurkchieva, D; Dimitrov, D; Radeva, V

    2015-01-01

    Results from UBVRI photometric observations of the pre-main sequence star GM Cep obtained in the period April 2011 - August 2014 are reported in the paper. Presented data are a continuation of our photometric monitoring of the star started in 2008. GM Cep is located in the field of the young open cluster Trumpler 37 and over the past years it has been an object of intense photometric and spectral studies. The star shows a strong photometric variability interpreted as a possible outburst from EXor type in previous studies. Our photometric data for a period of over six years show a large amplitude variability (Delta V ~ 2.3 mag.) and several deep minimums in brightness are observed. The analysis of the collected multicolor photometric data shows the typical of UX Ori variables a color reversal during the minimums in brightness. The observed decreases in brightness have a different shape, and evidences of periodicity are not detected. At the same time, high amplitude rapid variations in brightness typical for th...

  3. Moving beyond the GM debate.

    Directory of Open Access Journals (Sweden)

    Ottoline Leyser

    2014-06-01

    Full Text Available Once again, there are calls to reopen the debate on genetically modified (GM crops. I find these calls frustrating and unnecessarily decisive. In my opinion the GM debate, on both sides, continues to hamper the urgent need to address the diverse and pressing challenges of global food security and environmental sustainability. The destructive power of the debate comes from its conflation of unrelated issues, coupled with deeply rooted misconceptions of the nature of agriculture.

  4. Moving beyond the GM Debate

    OpenAIRE

    Ottoline Leyser

    2014-01-01

    Once again, there are calls to reopen the debate on genetically modified (GM) crops. I find these calls frustrating and unnecessarily decisive. In my opinion the GM debate, on both sides, continues to hamper the urgent need to address the diverse and pressing challenges of global food security and environmental sustainability. The destructive power of the debate comes from its conflation of unrelated issues, coupled with deeply rooted misconceptions of the nature of agriculture.

  5. Moving beyond the GM debate.

    Science.gov (United States)

    Leyser, Ottoline

    2014-06-01

    Once again, there are calls to reopen the debate on genetically modified (GM) crops. I find these calls frustrating and unnecessarily decisive. In my opinion the GM debate, on both sides, continues to hamper the urgent need to address the diverse and pressing challenges of global food security and environmental sustainability. The destructive power of the debate comes from its conflation of unrelated issues, coupled with deeply rooted misconceptions of the nature of agriculture. PMID:24914954

  6. Quaternary Glaciations in the Rio Mendoza Valley, Argentine Andes

    Science.gov (United States)

    Espizua, Lydia E.

    1993-09-01

    In the Rio Mendoza valley, five Pleistocene drifts and one Holocene drift are distinguished by multiple relative-age criteria, including surface-rock weathering, development of rock varnish, moraine morphology, soil-profile development, and stratigraphic relationships. Several absolute ages suggest a preliminary chronology. During the oldest (Uspallata) glaciation, a system of valley glaciers flowed 110 km from the Andean drainage divide and 80 km from Cerro Aconcagua to terminate at 1850 m. Drift of this ice advance is older than a widespread tephra dated by fission-track at 360,000 ± 36,000 yr. During the Punta de Vacas advance, ice terminated at 2350 m, while during the subsequent Penitentes advance, the glacier system ended at 2500 m. A travertine layer overlying Penitentes Drift has U-series age of 24,200 ± 2000 yr B.P. The distribution of Horcones Drift, which is inferred to represent the last glacial maximum, delimits an independent ice stream that flowed 22 km down Horcones valley to 2750 m. A later readvance (Almacenes) reached 3250 m. Confluencia Drift is considered to be Neoglacial in age and extends downvalley to 3300 m. The moraine sequence is compared with those studied by Caviedes (1972) along Rio Aconcagua on the Chilean flank of the Andes.

  7. The future of starch bioengineering: GM microorganisms or GM plants?

    Directory of Open Access Journals (Sweden)

    Kim Henrik eHebelstrup

    2015-04-01

    Full Text Available Plant starches regularly require extensive modification to permit subsequent applications. Such processing is usually done by the use of chemical and/or physical treatments. The use of recombinant enzymes produced by large-scale fermentation of GM microorganisms is increasingly used in starch processing and modification, sometimes as an alternative to chemical or physical treatments. However, as a means to impart the modifications as early as possible in the starch production chain, similar recombinant enzymes may also be expressed in planta in the developing starch storage organ such as in roots, tubers and cereal grains to provide a GM crop as an alternative to the use of enzymes from GM microorganisms. We here discuss these techniques in relation to important structural features and modifications of starches such as: starch phosphorylation, starch hydrolysis, chain transfer/branching and novel concepts of hybrid starch-based polysaccharides. In planta starch bioengineering is generally challenged by yield penalties and inefficient production of the desired product. However in some situations, GM crops for starch bioengineering without deleterious effects have been achieved.

  8. Acceptability of GM foods among Pakistani consumers.

    Science.gov (United States)

    Ali, Akhter; Rahut, Dil Bahadur; Imtiaz, Muhammad

    2016-04-01

    In Pakistan majority of the consumers do not have information about genetically modified (GM) foods. In developing countries particularly in Pakistan few studies have focused on consumers' acceptability about GM foods. Using comprehensive primary dataset collected from 320 consumers in 2013 from Pakistan, this study analyzes the determinants of consumers' acceptability of GM foods. The data was analyzed by employing the bivariate probit model and censored least absolute deviation (CLAD) models. The empirical results indicated that urban consumers are more aware of GM foods compared to rural consumers. The acceptance of GM foods was more among females' consumers as compared to male consumers. In addition, the older consumers were more willing to accept GM food compared to young consumers. The acceptability of GM foods was also higher among wealthier households. Low price is the key factor leading to the acceptability of GM foods. The acceptability of the GM foods also reduces the risks among Pakistani consumers. PMID:27494790

  9. Acceptability of GM foods among Pakistani consumers.

    Science.gov (United States)

    Ali, Akhter; Rahut, Dil Bahadur; Imtiaz, Muhammad

    2016-04-01

    In Pakistan majority of the consumers do not have information about genetically modified (GM) foods. In developing countries particularly in Pakistan few studies have focused on consumers' acceptability about GM foods. Using comprehensive primary dataset collected from 320 consumers in 2013 from Pakistan, this study analyzes the determinants of consumers' acceptability of GM foods. The data was analyzed by employing the bivariate probit model and censored least absolute deviation (CLAD) models. The empirical results indicated that urban consumers are more aware of GM foods compared to rural consumers. The acceptance of GM foods was more among females' consumers as compared to male consumers. In addition, the older consumers were more willing to accept GM food compared to young consumers. The acceptability of GM foods was also higher among wealthier households. Low price is the key factor leading to the acceptability of GM foods. The acceptability of the GM foods also reduces the risks among Pakistani consumers.

  10. COMMENTS ON "BVRI -PHOTOMETRY OF THE BRIGHTEST STARS IN THE MAGELLANIC CLOUDS" BY MENDOZA (1970

    Directory of Open Access Journals (Sweden)

    L. N. Georgiev

    2011-01-01

    Full Text Available In this paper I present a review of the article ¿BVRI -Photometry of the Brightest Stars in the Magellanic Clouds¿ by E. E. Mendoza V., 1970, BOTT, 5, 35, 269. I describe the background on which the ideas of the paper were developed, the techniques used and the obtained results. It is worth noting that Mendoza was one of the first to suggest the lower metal content of the Magellanic Clouds. Finally I present a brief comparison with the modern studies in the field.

  11. Simulation and evaluation of GM and non-GM segregation management strategies among European grain merchants

    OpenAIRE

    Coléno, François,

    2008-01-01

    International audience Considering the European regulations, a product need to be labelled as containing GM when the adventitious presence of GM material exceed 0.9%. During collection, crops from many fields are combined to fill a silo. Three management strategies to avoid the risk of mixing GM and non-GM crops were identified by a descriptive work based on cases studies in various region of France: defining GM and non-GM silos and production zones; specifying the timing of GM and non-GM ...

  12. Primer registro de Tityus trivittatus (Scorpiones: Buthidae en la provincia de Mendoza (Argentina First record of Tityus trivittatus (Scorpiones: Buthidae in Mendoza province (Argentina

    Directory of Open Access Journals (Sweden)

    Florencia Fernández Campón

    2009-06-01

    Full Text Available En la siguiente nota se informa sobre el primer registro del escorpión Tityus trivittatus Kraepelin en la provincia de Mendoza en el Barrio Campo Papa, departamento de Godoy Cruz. T trivittatus es dentro de nuestro país una de las especies de escorpiones con importancia médica, debido a que su veneno neurotóxico puede causar lesiones en el sistema nervioso y en algunos casos la muerte, particularmente en niños.This note reports the first record on the scorpion Tityus trivittatus Kraepelin in Mendoza province in the locality of Campo Papa, Godoy Cruz. T. trivittatus is one of the species of scorpion of medical importance in Argentina, due to the fact that its neurotoxic venom can damage the nervous system and may even be fatal in some cases, especially among children.

  13. GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900 MHz NMR analysis

    NARCIS (Netherlands)

    Pukin, A.V.; Weijers, C.A.G.M.; Lagen, van B.; Wechselberger, R.; Sun, B.; Gilbert, M.; Karwaski, M.F.; Florack, D.E.A.; Jacobs, B.C.; Tio-Gillen, A.P.; Belkum, van A.; Endtz, H.P.; Visser, G.M.; Zuilhof, H.

    2008-01-01

    Undec-10-enyl, undec-10-ynyl and 11-azidoundecyl glycoside analogues corresponding to the oligosaccharides of human gangliosides GM3, GM2 and GM1 were synthesized in high yields using glycosyltransferases from Campylobacter jejuni. Due to poor water solubility of the substrates, the reactions were c

  14. Genetics Home Reference: GM1 gangliosidosis

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions GM1 gangliosidosis GM1 gangliosidosis Enable ...

  15. GM technology and the Australian canola

    OpenAIRE

    Taing, William; Ahmadi-Esfahani, Fredoun Z.

    2009-01-01

    In this paper, we use a simulation model to measure the potential market and welfare effects of recently introduced genetically modified (GM) canola in Australia. The short-run results indicate that non-GM canola may emerge as a niche product commanding a premium. In the long run, GM technology appears to enhance aggregate welfare. However, when production cost savings are trivial and consumers become highly concerned about GM food products, aggregate welfare may decline. The policy implicati...

  16. SIMGRO, a GIS-Supported Regional Hydrologic Model in Irrigated Areas : Case study in Mendoza, Argentina

    NARCIS (Netherlands)

    Querner, E.P.; Morabito, J.A.; Tozzi, D.A.

    2008-01-01

    The SIMGRO hydrologic simulation model was extended to include irrigation practice. It could then be used to evaluate the effect of hydrologic changes in an irrigated area in the province of Mendoza, Argentina where, given an average annual rainfall of approximately 200mm , irrigation is crucial for

  17. Detection of a Proto-planetary Clump in the Habitable Zone of GM Cephei

    Science.gov (United States)

    Chen, W. P.; Hu, S. C.-L.

    2014-04-01

    GM Cephei is an active T Tauri star in the young open cluster Trumpler 37, showing abrupt UX Orionis type of photometric variability. Its light curves exhibit frequent, sporadic brightening events, each of <0.5 mag and lasting for days, which must have been originated from unsteady circumstellar accretion. In addition, the star undergoes a brightness drop up to ~1 mag lasting for about a month, during which the star became bluer when fainter. Moreover, the brightness drops seem to have a recurrence timescale of about 300 days. It is proposed that the brightness drop arises from obscuration of the central star by an orbiting dust concentration, exemplifying disk inhomogeneity in transition between grain coagulation and planetesimal formation in a young circumstellar disk. GM Cep was found to show a few percent polarization in the optical wavelengths, and an enhanced level of polarization during the occultation phase.

  18. Flood Risk in Motozintla de Mendoza, Chiapas: An Approximation

    Science.gov (United States)

    Rodriguez, F.; Novelo-Casanova, D. A.

    2012-12-01

    The town of Motozintla de Mendoza (15o 22' N and 92o 15' W) is located southern Chiapas, Mexico, and it is highly exposed to flood hazards. This community has suffered the impact of two disaster events due to this natural hazard in less than ten years, the first one in 1998 and the second one in 2005. The objective of this research is to assess the level of flood risk in the community of Motozintla. The methodology consisted of four steps: (1) Identification of the level of flood hazard; (2) Vulnerability assessment considering weighted variables according to their level of incidence on the local risk conditions; (3) Preparation of risk matrices for each area exposed to floods; and 4) Cartographic representation and spatial analysis of the results. We obtained a Geographical Information System (GIS) map for each group of analyzed vulnerabilities (structural, public services, socio-economic, existing plans in case of contingencies, and risk perception) and one map associated to global vulnerability (overposing of all estimated vulnerabilities). These maps demonstrates that the local conditions of structural vulnerability have a high incidence in the generation of risk, differing from the lack of public basic services, which although unfavorable for the population, it is not a deciding factor for preserving life or housing. Another interesting result is that the lack of preparation of the community to face a disaster generates a higher risk level than the other analyzed socioeconomic conditions. The global vulnerability allowed us to determine with greater detail the flood risk levels in the community. Our results indicate that the area in Motozintla with the highest level of flood risk is located in the margins of the Xelajú river, particularly the region that was flooded in 2005, which is precisely the area where the rivers Xelajú, Allende and La Mina meet and the river flow increases. Unfortunately, the northeasters part of this zone had been populated by people

  19. El volcanismo del Terciario superior del sur de Mendoza

    Directory of Open Access Journals (Sweden)

    F. E. Nullo

    2002-06-01

    Full Text Available Se describe por primera vez la petrografía y geoquímica de unidades volcánicas terciarias del sur de la provincia de Mendoza. Se analizan la nomenclatura estratigráfica y sus edades, estableciéndose una secuencia de eventos magmáticos ocurridos durante el Neógeno, comenzando con la evolución de un retro-arco, seguido por un arco magmático más joven. Se intenta respetar la nomenclatura estratigráfica existente, sin embargo, la definición de unidades se ha realizado sobre la base de las edades radimétricas y sus edades de cristalización, más sobre sus características petrográficas. La actividad magmática se extiende desde el Oligoceno superior al Mioceno superior, correspondiendo a el Ciclo Eruptivo Molle y el Ciclo Eruptivo Huincán, y comenzó con un episodio magmático basáltico inicial (CEM. Esta actividad se generó en la corteza inferior dominada por la concentración de gabros, dioritas y rocas híbridas (granulitas máficas. Debido a un engrosamiento de la corteza como consecuencia de la actividad tectónica durante Mioceno superior o por el estancamiento de magmas o por la combinación de ambos procesos, la formación de granulitas granatíferas resultó un producto distintivo de la corteza inferior. Con el desarrollo del arco magmático (CEH en el Mioceno superior, los magmas ascendieron desde la fuente mantélica, encontrándose con una corteza inferior granatífera, perdiendo capacidad de ascenso por falta de contraste de densidades, produciéndose una fusión extendida, la homogeinización y el ascenso, en equilibrio con la corteza baja, proceso que caracteriza el volcanismo de un arco magmático.

  20. Quaternary continetal back-arc evolution from southern Mendoza, Argentina

    Science.gov (United States)

    Espanon, Venera; Chivas, Allan; Dosseto, Anthony; Honda, Masahiko; Phillips, David; Matchan, Erin; Price, David

    2016-04-01

    The Quaternary evolution of the Payenia Basaltic Province (PBP) in southern Mendoza, Argentina has been investigated using a multi-dating approach in combination with pre-exiting geochemical data. This basaltic province covers an area of approximately 40000 km2 and is mainly characterised by backarc volcanism. In the current investigation nine new radiometric ages obtained using surface exposure, 40Ar/39Ar and thermoluminescence dating are presented. Six ages correspond to the late Pleistocene and three to the Holocene. The surface exposure ages obtained using cosmogenic 3He and 21Ne are in good agreement with previous publications and confidently suggest that part of this basaltic province was active at least 4000 years ago (taking a conservative approach). In addition, we combined the available geochronological and geochemical data to reconstruct the Quaternary evolution of this basaltic province. This approach was used to create maps of geospatial distribution of trace-element ratios to determine geochemical changes during the Pleistocene. Employing this method it is evident that two geochemical distinct types of magma were erupting at the same time interval within the PBP. In the north eastern part (Nevado volcanic field) of the PBP an arc-like signature is evident, while in the southern part (Río Colorado volcanic field) of the same basaltic province an Ocean Island Basalt (OIB) signature is evident. The arc-like signature in the north eastern part of the PBP, decreased during the Pleistocene in a north-west direction indicated by a reduction in Ba/La and La/Ta in the Nevado and Llancanelo volcanic field. The Holocene volcanism is restricted to the western side of the Payún Matrú volcanic field and is dominated by OIB-like signatures such as high Ta/Hf and low Ba/La and La/Ta. This contribution presents new geochronology for the PBP and confirms that two different types of volcanism occurred simultaneously during the Pleistocene, while the Holocene

  1. Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

    Science.gov (United States)

    Anheuser, Susi; Breiden, Bernadette; Schwarzmann, Günter; Sandhoff, Konrad

    2015-09-01

    Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and GM2 activator protein (GM2AP) at uncharged liposomal surfaces carrying GM2 as substrate generated only a physiologically irrelevant catabolic rate, even at pH 4.2. However, incorporation of anionic phospholipids into the GM2 carrying liposomes stimulated GM2 hydrolysis more than 10-fold, while the incorporation of plasma membrane stabilizing lipids (SM and cholesterol) generated a strong inhibition of GM2 hydrolysis, even in the presence of anionic phospholipids. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies. These lipids also reduced the interliposomal transfer rate of 2-NBD-GM1 by GM2AP, as observed in assays using Förster resonance energy transfer. Our data raise major concerns about the usage of recombinant His-tagged GM2AP compared with untagged protein. The former binds more strongly to anionic GM2-carrying liposomal surfaces, increases GM2 hydrolysis, and accelerates intermembrane transfer of 2-NBD-GM1, but does not mobilize membrane lipids.

  2. Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity[S

    Science.gov (United States)

    Anheuser, Susi; Breiden, Bernadette; Schwarzmann, Günter; Sandhoff, Konrad

    2015-01-01

    Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and GM2 activator protein (GM2AP) at uncharged liposomal surfaces carrying GM2 as substrate generated only a physiologically irrelevant catabolic rate, even at pH 4.2. However, incorporation of anionic phospholipids into the GM2 carrying liposomes stimulated GM2 hydrolysis more than 10-fold, while the incorporation of plasma membrane stabilizing lipids (SM and cholesterol) generated a strong inhibition of GM2 hydrolysis, even in the presence of anionic phospholipids. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies. These lipids also reduced the interliposomal transfer rate of 2-NBD-GM1 by GM2AP, as observed in assays using Förster resonance energy transfer. Our data raise major concerns about the usage of recombinant His-tagged GM2AP compared with untagged protein. The former binds more strongly to anionic GM2-carrying liposomal surfaces, increases GM2 hydrolysis, and accelerates intermembrane transfer of 2-NBD-GM1, but does not mobilize membrane lipids. PMID:26175473

  3. Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity.

    Science.gov (United States)

    Anheuser, Susi; Breiden, Bernadette; Schwarzmann, Günter; Sandhoff, Konrad

    2015-09-01

    Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and GM2 activator protein (GM2AP) at uncharged liposomal surfaces carrying GM2 as substrate generated only a physiologically irrelevant catabolic rate, even at pH 4.2. However, incorporation of anionic phospholipids into the GM2 carrying liposomes stimulated GM2 hydrolysis more than 10-fold, while the incorporation of plasma membrane stabilizing lipids (SM and cholesterol) generated a strong inhibition of GM2 hydrolysis, even in the presence of anionic phospholipids. Mobilization of membrane lipids by GM2AP was also inhibited in the presence of cholesterol or SM, as revealed by surface plasmon resonance studies. These lipids also reduced the interliposomal transfer rate of 2-NBD-GM1 by GM2AP, as observed in assays using Förster resonance energy transfer. Our data raise major concerns about the usage of recombinant His-tagged GM2AP compared with untagged protein. The former binds more strongly to anionic GM2-carrying liposomal surfaces, increases GM2 hydrolysis, and accelerates intermembrane transfer of 2-NBD-GM1, but does not mobilize membrane lipids. PMID:26175473

  4. Burkina Faso - BRIGHT II

    Data.gov (United States)

    Millenium Challenge Corporation — Millennium Challenge Corporation hired Mathematica Policy Research to conduct an independent evaluation of the BRIGHT II program. The three main research questions...

  5. Genetically Modified (GM) Foods and Ethical Eating.

    Science.gov (United States)

    Dizon, Francis; Costa, Sarah; Rock, Cheryl; Harris, Amanda; Husk, Cierra; Mei, Jenny

    2016-02-01

    The ability to manipulate and customize the genetic code of living organisms has brought forth the production of genetically modified organisms (GMOs) and consumption of genetically modified (GM) foods. The potential for GM foods to improve the efficiency of food production, increase customer satisfaction, and provide potential health benefits has contributed to the rapid incorporation of GM foods into the American diet. However, GM foods and GMOs are also a topic of ethical debate. The use of GM foods and GM technology is surrounded by ethical concerns and situational judgment, and should ideally adhere to the ethical standards placed upon food and nutrition professionals, such as: beneficence, nonmaleficence, justice and autonomy. The future of GM foods involves many aspects and trends, including enhanced nutritional value in foods, strict labeling laws, and potential beneficial economic conditions in developing nations. This paper briefly reviews the origin and background of GM foods, while delving thoroughly into 3 areas: (1) GMO labeling, (2) ethical concerns, and (3) health and industry applications. This paper also examines the relationship between the various applications of GM foods and their corresponding ethical issues. Ethical concerns were evaluated in the context of the code of ethics developed by the Academy of Nutrition and Dietetics (AND) that govern the work of food and nutrition professionals. Overall, there is a need to stay vigilant about the many ethical implications of producing and consuming GM foods and GMOs.

  6. Genetically Modified (GM) Foods and Ethical Eating.

    Science.gov (United States)

    Dizon, Francis; Costa, Sarah; Rock, Cheryl; Harris, Amanda; Husk, Cierra; Mei, Jenny

    2016-02-01

    The ability to manipulate and customize the genetic code of living organisms has brought forth the production of genetically modified organisms (GMOs) and consumption of genetically modified (GM) foods. The potential for GM foods to improve the efficiency of food production, increase customer satisfaction, and provide potential health benefits has contributed to the rapid incorporation of GM foods into the American diet. However, GM foods and GMOs are also a topic of ethical debate. The use of GM foods and GM technology is surrounded by ethical concerns and situational judgment, and should ideally adhere to the ethical standards placed upon food and nutrition professionals, such as: beneficence, nonmaleficence, justice and autonomy. The future of GM foods involves many aspects and trends, including enhanced nutritional value in foods, strict labeling laws, and potential beneficial economic conditions in developing nations. This paper briefly reviews the origin and background of GM foods, while delving thoroughly into 3 areas: (1) GMO labeling, (2) ethical concerns, and (3) health and industry applications. This paper also examines the relationship between the various applications of GM foods and their corresponding ethical issues. Ethical concerns were evaluated in the context of the code of ethics developed by the Academy of Nutrition and Dietetics (AND) that govern the work of food and nutrition professionals. Overall, there is a need to stay vigilant about the many ethical implications of producing and consuming GM foods and GMOs. PMID:26709962

  7. The world of "GM-free".

    Science.gov (United States)

    Moses, Vivian; Brookes, Graham

    2013-01-01

    The rapid global development of agricultural production systems using seeds derived from genetic modification (GM) has been paralleled by the growth of attempts to keep at least a part of the world's agriculture and food as free from GM-crops and their products as possible. The ideal for some proponents of such "GM-free" activity would be a total absence, usually styled "zero content"; others, perhaps more realistically, opt for a definition usually not precisely defined that allows for minimal trace levels of GM material. The reasons for wanting "GM-free" agriculture and its products are varied; they include philosophical and religious beliefs, concern for human (and animal) health--and for "the environment"-as well as commercial and political interests. With such a variety of motivations, and in the absence of legal rulings, the definitions of "GM-free" vary according to inclination and circumstances. Whatever the precise meaning, the maintenance of a "GM-free" product stream in a world where GM crop production is widespread requires the establishment of identity preservation and segregation systems in which traceability and testing are cornerstones. Inevitably these have cost implications for the supply chain and/or the ultimate consumer. In a number of countries different forms of "GM-free" labels exist for some products; the style of such labels is variable with schemes and labels typically voluntary or privately organized. In more recent years, some governments have begun to regularize the definition and meaning of "GM-free." We conclude our analysis by exploring consumer reactions both to "GM-free" and to "GM-free" labels, and ask who ultimately benefits from preserving a product stream substantially or entirely devoid of GM-content.

  8. Photometry and Polarization of the UXor Type Young Star GM Cep

    Science.gov (United States)

    Huang, Po-Chieh; Chen, Chang-Yao; Hu, Chia-Ling; Chen, Wen-Ping

    2015-08-01

    UX Orionis stars, or UXORs, are a sub-type of Herbig Ae/be or T Tauri stars exhibiting sporadic extinction of stellar light due to circumstellar dust obscuration. GM Cep is such a UXOR in the young (~4 Myr) open cluster Trumper 37 at ~900 pc, showing prominent infrared access, H-alpha emission, and abrupt brightness variation. Here we present intense multi-color photometric monitoring from 2009 to 2015, together with the century-long photometric behavior reported in the literature, to add to the study by Chen et al. (2012) that GM Cep showed (i) sporadic brightening on a time scale of days due to young stellar accretion, (ii) occultation events, each lasting for a couple months, with a probable recurrence time of about two years, (iii) normal dust reddening as the star became redder when dimmer, (iv) the unusual “blueing” phenomena near the brightness minima when the star appeared bluer when dimmer. The occultation events may be caused by a dust clump, signifying the density inhomogeneity in a young stellar disk from grain coagulation to planetesimal formation. We present evidence of possible radial drift of the clump toward the star, stretching longer along the orbit and thinner in the line of sight. GM Cep is moderately polarized, from 4% to 9% in g, r, and i bands, with the level of polarization anticorrelated with the brightness in the bright state, during which the dust clump is back-scattering stellar light.

  9. Economic impact of GM crops

    Science.gov (United States)

    Brookes, Graham; Barfoot, Peter

    2014-01-01

    A key part of any assessment of the global value of crop biotechnology in agriculture is an examination of its economic impact at the farm level. This paper follows earlier annual studies which examined economic impacts on yields, key costs of production, direct farm income and effects, and impacts on the production base of the four main crops of soybeans, corn, cotton and canola. The commercialization of genetically modified (GM) crops has continued to occur at a rapid rate, with important changes in both the overall level of adoption and impact occurring in 2012. This annual updated analysis shows that there have been very significant net economic benefits at the farm level amounting to $18.8 billion in 2012 and $116.6 billion for the 17-year period (in nominal terms). These economic gains have been divided roughly 50% each to farmers in developed and developing countries. GM technology have also made important contributions to increasing global production levels of the four main crops, having added 122 million tonnes and 230 million tonnes respectively, to the global production of soybeans and maize since the introduction of the technology in the mid-1990s. PMID:24637520

  10. Sunspot Bright Points

    CERN Document Server

    Choudhary, Debi Prasad

    2010-01-01

    We used the flux calibrated images through the Broad Band Filter Imager and Stokes Polarimeter data obtained with the Solar Optical Telescope onboard the Hinode spacecraft to study the properties of bright points in and around the sunspots. The well isolated bright points were selected and classified as umbral dot, peripheral umbral dot, penumbral grains and G-band bright point depending on their location. Most of the bright points are smaller than about 150 km. The larger points are mostly associated with the penumbral features. The bright points are not uniformly distributed over the umbra but preferentially located around the penumbral boundary and in the fast decaying parts of umbra. The color temperature of the bright points, derived using the continuum irradiance, are in the range of 4600 K to 6600 K with cooler ones located in the umbra. The temperature increases as a function of distance from the center to outside. The G-band, CN-band and CaII H flux of the bright points as a function of their blue ba...

  11. Effect of a cyanobacterial community on calcium carbonate precipitation in Puente del Inca (Mendoza, Argentina)

    OpenAIRE

    Ferrari, S.G.; Italiano, M.C.; de Silva, H J

    2002-01-01

    The involvement of cyanobacteria in the precipitation process forming calcium carbonate was studied in samples collected at a geothermal spring located in an area close to Puente del Inca (Mendoza, Argentina). In the summer season profuse cyanobacterial growth is observed at Puente del Inca in areas exposed to sunlight and over which thermal water flows. Differences in cellular structure allowed the recognition of strains of Oscillatoria, Spirulina, Plectonema, and Nostoc, Oscillatoria and...

  12. Experiences with a PDS 2020 GM

    Science.gov (United States)

    Teuber, D.

    1984-07-01

    Various perturbations which occurred during the operation of a PDS 2020 GM microdensitometer are reviewed. The effects of elevated temperature, vibration, transient electrical noise, and photometric perturbations are briefly discussed. Sample astronomical results from the PDS 2020 GM unit are presented.

  13. Adoption of GM Technology at Farm Level

    OpenAIRE

    Conor Keelan; Fiona Thorne; Paul Flanagan; Carol Newman; Ewen Mullins

    2008-01-01

    In this paper a probit model is used to assess the factors that will influence the decision of Irish farmers to adopt GM technology should they be given a choice in the near future of selecting between GM and non-GM varieties of crops. The theory underlying the model emanates from the wide literature on adoption and diffusions theory. The decision of whether or not to use new agricultural technologies has generally been found to be a function of specific features of the particular technology ...

  14. Changing climatic and anthropogenic influences on the Bermejo wetland, through archival documents – Mendoza, Argentina, 16th–20th centuries

    Directory of Open Access Journals (Sweden)

    M. R. Prieto

    2011-11-01

    Full Text Available The wrong management of watering in the highest zones of the Mendoza northern oasis, the topography of the terrain and the deficient drainage, together with neotectonics phenomena, but mostly a dramatic and progressive increase of the Rio Mendoza flow volume originated the expansion of the wetlands area at the NE of the city of Mendoza at the turn of the 18th century, while in previous centuries it had retracted to a minimum. The area grew until reaching the dimension of large wetlands in the lowest oasis zones, resulting from a larger runoff and soil saturation by the rise of the phreatic layers. This situation remained throughout the 19th century, affecting the extension and use of the available land for human activity. The purpose of this study was to research this process that culminated in 1930 with the partial desiccation of the area. We have given particular importance to the influence of the climatic fluctuations in the Cordillera de los Andes and to the consequent variations of the Rio Mendoza flow volume in this process. For the analysis we used snowfall series at the cordillera and flow volume of the Rio Mendoza, built by Prieto (2009 with documental data. We analyzed which were the mediate and immediate consequences of the growth and later desiccation of the wetlands over the environment and its present repercussion on the ecosystem (salinization, poor soil drainage, soil alkalinization, sedimentation. In addition, we have also worked over georeferenced historic charts that partially reflect the behavior of the Cienaga del Bermejo during the 18th, 19th and 20th centuries. This behavior characterized by "growth pulses" and retraction moments is reflected in the analyzed charts, where those moments of major growth coincide with cycles of bigger snowstorms and larger flow volume in the Rio Mendoza.

  15. VITICULTURA Y POLÍTICA INTERNACIONAL: EL INTENTO DE REINCORPORAR A MENDOZA Y SAN JUAN A CHILE (1820-1835

    Directory of Open Access Journals (Sweden)

    PABLO LACOSTE

    2006-06-01

    Full Text Available Entre 1830 y 1835 algunos dirigentes de Mendoza y San Juan, provincias vitivinícolas, trataron de separarse de la República Argentina y regresar a Chile, tal como en la época colonial. Durante más de dos siglos, Mendoza y San Juan fueron parte del Corregimiento de Cuyo del Reino de Chile. Esta situación cambió desde 1776 con la creación del Virreinato del Río de la Plata. Después de la Revolución de 1810, Mendoza y San Juan formaron parte de la República Argentina. Pero algunos años después de la independencia, un grupo descontento con la acción y decisiones del gobierno de Buenos Aires, inició acciones orientadas a la secesión. Este artículo investiga las razones y motivaciones socioeconómicas de este grupoBetween 1830 and 1835 some leaders of Mendoza and San Juan, wine industry oriented provinces, attempted to withdrawal from Argentina Republic, and come back to Chile such as in colonial times. During more than two centuries, Mendoza and San Juan were members of Cuyo Province in Chile's Kingdom. This situation changed since 1776 because the creation of the River Plate Viceroyalty. After Revolution of 1810, Mendoza and San Juan took part of Argentina Republic. But some years after the independence, a group discontented with de action and decision of Buenos Aires government begun the action oriented to secession. This paper explores the socioeconomic reasons and motivation of this group

  16. La transición de periferia a frontera: mendoza en el siglo XVII

    Directory of Open Access Journals (Sweden)

    Margarita Gasc\\u00F3n

    2001-01-01

    Full Text Available El análisis de la evolución de Mendoza en el siglo XVII permite diferenciar las características de un asentamiento en la periferia de aquellas características que corresponden a una sociedad de frontera. Fundada en 1561 en la periferia imperio español en América a principios del siglo XVII, Mendoza era una comunidad con escasa población, con reducido comercio y de lento desarrollo urbano; todas características de las colonias periféricas. A lo largo de la primera parte del siglo XVII, sin embargo, Mendoza se fue configurando como una sociedad de frontera. Las causas de este devenir frontera se relacionan con la revuelta araucana y con las consecuencias del establecimiento de la frontera geográfico-militar en el río Biobio. El trabajo comienza con una revisión de los términos frontera y periferia tal como se encuentran empleados en los análisis de algunos autores representativos de la historiografía sobre fronteras para las Américas. Luego se reconstruye la evolución de periferia a frontera en Mendoza; un proceso que comenzó varias décadas después de su fundación en 1561. Tal fundación no estuvo guiada por la necesidad de consolidar o de proteger una zona de frontera, de modo que no fue fundada ni como presidio ni como misión, que son las típicas instituciones de frontera y que encontramos en numerosas fronteras del imperio español, como ser en la Florida y en el norte de México. A fines del siglo XVI Mendoza fue fundada como uno de los tantos asentamientos que permitirían a los españoles seguir avanzando en la conquista y colonización de nuevos territorios. Sin embargo, la revuelta araucana de 1598-1599 provocó el quiebre de tal desenvolvimiento de la conquista porque truncó la esperanza de una futura expansión española hacia el sur. Más allá del fiasco militar de la derrota de Curalaba, la rebelión nativa obligó a la coronaa establecer un ejército profesional de alrededor de 2.000 hombres, cuya permanencia

  17. M@gm@ e i miei ritardi

    Directory of Open Access Journals (Sweden)

    Marina Brancato

    2008-12-01

    Full Text Available Sono certa che M@gm@ continuerà ad essere viatico di riflessione nell’ibridazione con altri saperi. Senza alcun antagonismo. Patrimonio espressivo e strategico nel discorso scientifico.

  18. ARE US CONSUMERS TOLERANT OF GM FOODS?

    OpenAIRE

    Rousu, Matthew C.; Huffman, Wallace E; Shogren, Jason F.; Tegene, Abebayehu

    2002-01-01

    Many countries require labeling for GM food products. These countries often have different levels of genetic modification that they will tolerate before a food product must be labeled as genetically modified. For example, the European Union and Australia allow up to one percent of any ingredient in a food product to be GM before the product must be labeled as genetically modified. Japan allows 5% of any ingredient to be genetically modified before the product must be labeled as such. The Unit...

  19. Morfometría de las poblaciones humanas tardías del sur de Mendoza

    OpenAIRE

    Novellino, Paula; Barrientos, Gustavo; Pérez, Sergio Iván; Bernal, Valeria; Béguelin, Marien

    2003-01-01

    El propósito de esta comunicación es presentar los primeros resultados de un estudio morfométrico integral de muestras procedentes de diversos sitios arqueológicos del sur de Mendoza, correspondientes en su mayor parte al Holoceno tardío (ca. 3000 años radiocarbónicos AP hasta momentos históricos). El objetivo del mencionado estudio, realizado en colaboración entre miembros del Museo Municipal de Historia Natural de San Rafael y de la Facultad de Ciencias Naturales y Museo de la UNLP, es obte...

  20. Primer registro de Tityus trivittatus (Scorpiones: Buthidae en la provincia de Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Florencia FERNÁNDEZ CAMPÓN

    2009-01-01

    Full Text Available En la siguiente nota se informa sobre el primer registro delescorpión Tityus trivittatus Kraepelin en la provincia de Mendoza en el Barrio Campo Papa, departamento de Godoy Cruz. T. trivittatus es dentro de nuestro país una de las especies de escorpiones con importancia médica, debido a que su veneno neurotóxico puede causar lesiones en el sistema nervioso y en algunos casos la muerte, particularmente en niños.

  1. The Coexistence of GM and non-GM Crops and the Role of Consumer Preferences

    OpenAIRE

    Merel, Pierre R.; Carter, Colin A.

    2005-01-01

    Crop coexistence is now at the core of the debate on GM technology in Europe. New regulations are being designed in the E.U. in order to "correct" potential production externalities and ensure that conventional and organic production will remain a profitable alternative for farmers. We use a simple Mussa-Rosen type model of preferences to capture the effects of introducing a cost-saving GM crop on incumbent crops, taking explicitly into account consumers' distaste for GM food products. Using ...

  2. Cost and benefits for the segregation of GM and non-GM compound feed

    OpenAIRE

    Gryson, Nicolas; Eeckhout, Mia; Neijens, Tom

    2008-01-01

    Measures are being developed and implemented enabling the co-existence of conventional, genetically modified (GM) and organic cropping systems. In order to segregate GM from conventional crops in the entire supply chain, a food or feed company has to reorganise its production. This may involve for dedication of the production line to non-GM, or production can be organised on the same plant, using spatial or temporal segregation. In practice, only the latter method is used in the feed industry...

  3. The brightness of colour.

    Directory of Open Access Journals (Sweden)

    David Corney

    Full Text Available BACKGROUND: The perception of brightness depends on spatial context: the same stimulus can appear light or dark depending on what surrounds it. A less well-known but equally important contextual phenomenon is that the colour of a stimulus can also alter its brightness. Specifically, stimuli that are more saturated (i.e. purer in colour appear brighter than stimuli that are less saturated at the same luminance. Similarly, stimuli that are red or blue appear brighter than equiluminant yellow and green stimuli. This non-linear relationship between stimulus intensity and brightness, called the Helmholtz-Kohlrausch (HK effect, was first described in the nineteenth century but has never been explained. Here, we take advantage of the relative simplicity of this 'illusion' to explain it and contextual effects more generally, by using a simple Bayesian ideal observer model of the human visual ecology. We also use fMRI brain scans to identify the neural correlates of brightness without changing the spatial context of the stimulus, which has complicated the interpretation of related fMRI studies. RESULTS: Rather than modelling human vision directly, we use a Bayesian ideal observer to model human visual ecology. We show that the HK effect is a result of encoding the non-linear statistical relationship between retinal images and natural scenes that would have been experienced by the human visual system in the past. We further show that the complexity of this relationship is due to the response functions of the cone photoreceptors, which themselves are thought to represent an efficient solution to encoding the statistics of images. Finally, we show that the locus of the response to the relationship between images and scenes lies in the primary visual cortex (V1, if not earlier in the visual system, since the brightness of colours (as opposed to their luminance accords with activity in V1 as measured with fMRI. CONCLUSIONS: The data suggest that perceptions

  4. Flow cytometry measurement of GM-CSF receptors in acute leukemic blasts, and normal hemopoietic cells.

    Science.gov (United States)

    Lanza, F; Castagnari, B; Rigolin, G; Moretti, S; Latorraca, A; Ferrari, L; Bardi, A; Castoldi, G

    1997-10-01

    A quantitative analysis of expression levels of GM-CSF receptors was performed by flow cytometry in different disease categories, ie AML (n = 72), ALL (n = 18), and MDS (n = 12), as well as 12 healthy volunteers, using three different unconjugated GM-CSF/R monoclonal antibodies (McAbs) (HGM-CSFR (CD116), M5D12, 4B5F5), and appropriate standards. By using the reference HGM-CSFR McAb, in healthy subjects we found detectable levels of GM-CSF/R on blood monocytes (mean MESF (molecules of equivalent soluble fluorochrome)/cell: 36.1 x 10[3]), neutrophils (mean MESF/cell: 7.4 x 10[3]), bone marrow (BM) myelo-monocytic precursors (MESF range for the myeloid component, ie promyelocytes, myelocytes, metamyelocytes: 11.7-40.5 x 10[3], and for the monocytic lineage: 25.7-69.2 x 10[3]), and in two distinct subsets of BM CD34+ progenitor cells (GM-CSF/R dim: 2.5 x 10[3] MESF/cell, GM-CSF/R bright (10% of the total number of CD34 cells: 22.0 x 10[3] MESF/cell). In these subjects, there was no correlation between the expression levels of GM-CSF/R and CFU (CFU-GM, CFU-GEMM, BFU-E) colony production. Among the AML samples, M5D12 McAb was positive in 33%, 4B5F5 McAb in 90%, and HGM-CSF/R McAb in 78% of the cases examined (range of MESF/cell for the HGM-CSFR McAb: 0.9 x 10[3]-106.7 x 10[3]). The highest MESF values were seen in the M5 FAB subvariety (mean: 39.4 x 10[3]), where all the patients tested (n = 20) showed a strong positivity for the HGM-CSFR McAb. On the contrary, all ALL samples were GM-CSF/R negative except in two patients, who displayed a dim GM-CSF/R positivity (My+ALL: 1.3 x 10[3] MESF/cell; pro-B ALL: 1.0 x 10[3] MESF/cell). In most (>70%) M1 FAB subtypes, GM-CSF/R+ blasts co-expressed CD34low, HLA-DRhigh, CD33, CD38 antigens, and had little or no capacity to form CFU-GM colonies. GM-CSF/R+ blasts from the M5 FAB category were also positive for CD14, CD11c, CD33 and CD87. Furthermore, the number of GM-CSF/R expressed by leukemic cells from five out of 72 (7%) AML

  5. CA BrightStor

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    CA推出的BrightStor系列存储管理解决方案已经成为企业电子商务体系架构管理战略中举足轻重的组成部分。BrightStor是一整套企业级的智能化存储管理解决方案,定位在存储硬件设备和上层应用之间,通过各种集成化的产品和工具为驻留在企业任何位置的数据提供全方位的、有效的存储管理和保护。

  6. Bright Economic Prospects

    Institute of Scientific and Technical Information of China (English)

    Zhang Minqiu

    2004-01-01

    @@ India is expected to register an 8.2% growth rate for the 2003-04 fiscal year. The overall economic situation this year has been satisfactory despite the scaled down 6-6.5% growth rate for the new fiscal year due to oil price hikes, reduced monsoon volume and some 7% inflation. Judging from the following factors, bright prospects are in store for the country down the road.

  7. Genetics Home Reference: GM2-gangliosidosis, AB variant

    Science.gov (United States)

    ... of GM2-gangliosidosis, AB variant: Genetic Testing Registry: Tay-Sachs disease, variant AB These resources from MedlinePlus offer ... AB variant Activator Deficiency/GM2 Gangliosidosis Activator-deficient Tay-Sachs disease GM2 Activator Deficiency Disease GM2 gangliosidosis, type ...

  8. Danish farmer’s perception of GM-crops

    DEFF Research Database (Denmark)

    Søndergaard, Janus; Pedersen, Søren Marcus; Gylling, Morten

    2005-01-01

    This paper presents a study of 185 farmer’s perception of GM-crops in Denmark. The respondent’s attitude to GM-crops mainly reflects a conservative view of the adoption of GM-crops. Among farmers only the exciting crops in rotation is seen as their future potential GM-crops. Findings from...

  9. Water in the Mendoza, Argentina, food processing industry: water requirements and reuse potential of industrial effluents in agriculture

    Directory of Open Access Journals (Sweden)

    Alicia Elena Duek

    2016-04-01

    Full Text Available This paper estimates the volume of water used by the Mendoza food processing industry considering different water efficiency scenarios. The potential for using food processing industry effluents for irrigation is also assessed. The methodology relies upon information collected from interviews with qualified informants from different organizations and food-processing plants in Mendoza selected from a targeted sample. Scenarios were developed using local and international secondary information sources. The results show that food processing plants in Mendoza use 19.65 hm3 of water per year; efficient water management practices would make it possible to reduce water use by 64%, i.e., to 7.11 hm3. At present, 70% of the water is used by the fruit and vegetable processing industry, 16% by wineries, 8% by mineral water bottling plants, and the remaining 6% by olive oil, beer and soft drink plants. The volume of effluents from the food processing plants in Mendoza has been estimated at 16.27 hm3 per year. Despite the seasonal variations of these effluents, and the high sodium concentration and electrical conductivity of some of them, it is possible to use them for irrigation purposes. However, because of these variables and their environmental impact, land treatment is required.

  10. Plagas de la agricultura en Mendoza: la langosta en los comienzos de la vitivinicultura moderna (1890-1900

    Directory of Open Access Journals (Sweden)

    Eduardo Pérez Romagnoli

    2011-12-01

    Full Text Available El trabajo se refiere a la presencia de la langosta en Mendoza en los comienzos de la especialización vitivinícola, en la década de 1890. Comprende aspectos sobre su biogeografía, antecedentes del insecto en nuestro país, los primeros inventos nacionales para enfrentar sus ataques. Con relación a las invasiones de la Schistocerca americana en Mendoza, se indaga sobre la organización estatal y la participación de la sociedad para combatirla, incluyendo algunos problemas y daños causados en la agricultura.The study refers to the presence of locust in Mendoza at the beginning of wine specialization, in the decade of 1890. It includes aspects on biogeography, precedents of the insect in our country, and first national inventions to face its assaults. In relation to invasions of Schistocercaamericana in Mendoza, the study researches on state organization and social participation to attack the plague, including some problems and damages caused in agriculture.

  11. Sauropod and theropod dinosaur tracks from the Upper Cretaceous of Mendoza (Argentina): Trackmakers and anatomical evidences

    Science.gov (United States)

    González Riga, Bernardo Javier; Ortiz David, Leonardo Daniel; Tomaselli, María Belén; dos Anjos Candeiro, Carlos Roberto; Coria, Juan Pedro; Prámparo, Mercedes

    2015-08-01

    New findings of dinosaur ichnites from Agua del Choique section (Mendoza Province, Argentina) provides ichnological and anatomical information about the Cretaceous sauropods and theropods. Around 330 tracks distributed in six footprint levels were identified in this area, one of most important of South America. Two ichnocenoses are located in different paleoenvironmental contexts. In the Anacleto Formation (early Campanian) around 20 titanosaurian tracks were found in floodplain and ephemeral channel deposits. Herein, one pes track shows three claw impressions and this is congruent to two new titanosaur specimens recently discovered in Mendoza Province that have articulated and complete pedes. In this context, for the first time to titanosaurs, ichnological evidences are supported by skeletal elements. In the Loncoche Formation (late Campanian-early Maastrichtian) titanosaurian tracks of Titanopodus mendozensis are abundant (around 310 tracks) and were produced by titanosaurs that walked in a very wet substrate of tidally dominated deltas related with the first Atlantic transgression for northern Patagonia. In this facies association, three different trydactl tracks indicate the presence of small theropods (1-2 m long), expanding the knowledge about the faunistic components that lived in these marine marginal environments.

  12. Regulating coexistence of GM and non-GM crops without jeopardizing economic incentives.

    Science.gov (United States)

    Demont, Matty; Devos, Yann

    2008-07-01

    The ongoing debate about the coexistence of genetically modified (GM) and non-GM crops in the European Union (EU) mainly focuses on preventive measures needed to keep the adventitious presence of GM material in non-GM products below established tolerance thresholds, as well as on issues covering questions of liability and the duty to redress the incurred economic harm once adventitious mixing in non-GM products has occurred. By contrast, the interplay between the economic incentives and costs of coexistence has attracted little attention. The current overemphasis on the technical aspects and cost of coexistence over its economic incentives might lead EU policy-makers to adopt too stringent and rigid regulations on coexistence. Therefore, we argue for flexible coexistence regulations that explicitly take into account the economic incentives for coexistence. Our arguments provide a timely and important framework for EU policy-makers, who are currently struggling to implement coherent coexistence regulations in all member states.

  13. Soybean GmMYB76,GmMYB92,and GmMYB177 genes confer stress tolerance in transgenic Arabidopsis plants

    Institute of Scientific and Technical Information of China (English)

    Yong Liao; Hong-Feng Zou; Hui-Wen Wang; Wan-Ke Zhang; Biao Ma; Jin-Song Zhang; Shou-Yi Chen

    2008-01-01

    MYB-type transcription factors contain the conserved MYB DNA-binding domain of approximately 50 amino acids and are involved in the regulation of many aspects of plant growth,development,metabolism and stress responses.From soybean plants,we identified 156 GmMYB genes using our previously obtained 206 MYB unigenes,and 48 were found to have full-length open-reading frames.Expressions of all these identified genes were examined,and we found that expressions of 43 genes were changed upon treatment with ABA,salt,drought and/or cold stress.Three GmMYB genes,GmMYB76,GmMYB92 and GmMYB177,were chosen for further analysis.Using the yeast assay system,GmMYB76 and GmMYB92 were found to have transactivation activity and can form homodimers.GmMYBI77 did not appear to have transactivation activity but can form heterodimers with GmMYB76.Yeast onehybrid assay revealed that all the three GmMYBs could bind to cis-elements TAT AAC GGT TTT TT and CCG GAA AAAAGG AT,but with different affinity,and GmMYB92 could also bind to TCT CAC CTA CC.The transgenic Arabidopsis plants overexpressing GmMYB76 or GmMYB177 showed better performance than the GmMYB92-transgenic plants in salt and freezing tolerance.However,these transgenic plants exhibited reduced sensitivity to ABA treatment at germination stage in comparison with the wild-type plants.The three GmMYB genes differentially affected a subset of stress-responsive genes in addition to their regulation of a common subset of stress-responsive genes.These results indicate that the three GmMYB genes may play differential roles in stress tolerance,possibly through regulation of stress-responsive genes.

  14. Low surface brightness galaxies

    Science.gov (United States)

    Vanderhulst, J. M.; Deblok, W. J. G.; Mcgaugh, S. S.; Bothun, G. D.

    1993-01-01

    A program to investigate the properties of low surface brightness (LSB) galaxies involving surface photometry in U, B, V, R, I, and H-alpha, HI imaging with the Westerbork Synthesis Radio Telescope (WSRT) and the very large array (VLA) and spectrophotometry of H2 regions in LSB galaxies is underway. The goal is to verify the idea that LSB galaxies have low star formation rates because the local gas density falls below the critical density for star formation, and to study the stellar population and abundances in LSB galaxies. Such information should help understanding the evolutionary history of LSB galaxies. Some preliminary results are reported.

  15. Functional studies of soybean (Glycine max L.) seed LEA proteins GmPM6, GmPM11, and GmPM30 by CD and FTIR spectroscopy

    NARCIS (Netherlands)

    Hoekstra, F.A.

    2012-01-01

    The protein and mRNA levels of late embryogenesis abundant (LEA) genes may be linked to osmotic stresses. Here, we characterized three soybean hydrophilic LEA proteins – GmPM11 (LEA I), GmPM6 (LEA II), and GmPM30 (LEA III) – by circular dichroism and Fourier transform infrared spectroscopy. Structur

  16. GM-CSF and phorbol esters modulate GM-CSF receptor expression by independent mechanisms.

    Science.gov (United States)

    Brizzi, M F; Arduino, C; Avanzi, G C; Bussolino, F; Pegoraro, L

    1991-07-01

    Human granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.1 nM) down-modulates its receptor in IL-3/GM-CSF dependent M-07e cells, in KG-1 cells and normal granulocytes, whereas phorbol esters 12-O-tetradecanoylphorbol-13-acetate (TPA) (2 nM) down-modulates the GM-CSF receptor in M-07e cells and granulocytes but not in KG-1 cells. As data analysis shows by nonlinear regression, the decreased binding ability depends on a reduction of the binding sites with no significant change of their dissociation constant. To gain insight into the mechanisms involved in the GM-CSF receptor regulation, we investigated the role of protein kinase C (PKC). GM-CSF, unlike TPA, was unable to activate PKC in all the cells studied. Moreover, unlike TPA, GM-CSF was still able to down-modulate its receptor in cells where PKC was inhibited by 1-(5-isoquinolonesulphonyl)-2-methylpiperazine (H7) and staurosporine or in cells where PKC was exhausted by prolonged incubation with 1 microM TPA. Finally, the receptor re-expression rate was accelerated by protein kinases inhibitors. These results, taken together, indicate the presence of a PKC-dependent and -independent down-modulation mechanism and a negative role of the endogeneous protein kinases in GM-CSF receptor re-expression.

  17. The loss from underutilizing GM technologies

    NARCIS (Netherlands)

    Zilberman, David; Kaplan, Scott; Wesseler, Justus

    2015-01-01

    This article introduces a framework based on a real-option approach to assess the economics of delaying the introduction of genetically modified (GM) technologies in agriculture due to concerns about their unintended effects (unexpected environmental side effects). We applied our framework to ana

  18. Geschichte des Gmünder Arenhauses

    OpenAIRE

    Graf, Klaus

    1989-01-01

    Der Beitrag behandelt die Geschichte des 1888 abgebrochenen Arenhauses in Schwäbisch Gmünd (Markplatz Nr. 35), das auf ein romanisches Steinhaus zurückgeht und 1353 von Nikolaus im Steinhaus an das Spital verkauft wurde.

  19. OPS und ICD-10-GM 2009

    OpenAIRE

    DIMDI-Pressestelle

    2007-01-01

    Das DIMDI nimmt ab sofort Änderungsvorschläge zu den Klassifikationen ICD-10-GM (Internationale Klassifikation der Krankheiten) und OPS (Operationen- und Prozedurenschlüssel) für die Versionen 2009 entgegen. Der Redaktionsschluss ist am 29. Februar 2008.

  20. OPS und ICD-10-GM 2008

    OpenAIRE

    DIMDI-Pressestelle

    2006-01-01

    Das DIMDI nimmt ab sofort Änderungsvorschläge zu den Klassifikationen ICD-10-GM (Internationale Klassifikation der Krankheiten) und OPS (Operationen- und Prozedurenschlüssel) für die Versionen 2008 entgegen. Der Redaktionsschluss ist am 28. Februar 2007.

  1. Human health concerns with GM crops.

    Science.gov (United States)

    Malarkey, Trish

    2003-11-01

    Biotechnology was used in the first generation of so-called 'GM' crops to provide growers with complimentary and sometimes alternative crop management solutions to pesticides. Selected host genes or genes identified from other plants or non-plant sources are modified or transferred to a crop plant. The new or altered protein expression resulting from these modifications confer on the plant a desired physiological trait, such as resistance to particular herbicides or insect pests. Second generation modifications provide traits such as enhanced nutritional or health-promoting characteristics that are of benefit to consumers. The commonly raised concerns about possible implications for human health are: inherent toxicity of the novel gene and their products, the potential to express novel antigenic proteins or alter levels of existing protein allergens, the potential for unintended effects resulting from alterations of host metabolic pathways or over expression of inherently toxic or pharmacologically active substances and the potential for nutrient composition in the new food occur differing significantly from a conventional counterpart. Foods produced using biotechnology are subjected to far greater levels of scrutiny than foods produced by traditional plant breeding techniques. The accepted analytical, nutritional and toxicological methods employed to support this scrutiny and to assess and assure that a 'GM' food is a safe and nutritious as its 'non-GM' counterpart are discussed. The challenges associated with identifying unintended effects in whole GM foods and the promise new (proteomics/genomic) technologies offer opposite traditional toxicity testing paradigms are appraised. PMID:14644323

  2. GM plants, farmers and the public

    DEFF Research Database (Denmark)

    Lassen, Jesper; Sandøe, Peter

    2009-01-01

    The controversy in Europe over genetically manipulated (GM) foods has been conceived largely as a conflict between a reluctant public and a more enthusiastic agri-food sector. As a result, the political focus has been on the public to the neglect of other actors, such as the farmers, whose willin...

  3. The GM foods debate in Europe

    DEFF Research Database (Denmark)

    Scholderer, Joachim

    2005-01-01

    The debate on genetically modified (GM) foods has been led on multiple levels in Europe, including such diverse frames of reference as economic policy and international trade, environmental risk, bioethics, consumer protection and food safety. The shifting frames of reference are traced over...

  4. High Density GEOSAT/GM Altimeter Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The high density Geosat/GM altimeter data south of 30 S have finally arrived. In addition, ERS-1 has completed more than 6 cycles of its 35-day repeat track. These...

  5. Nueva ruralidad en territorios periféricos: los productores caprinos del noreste de Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Laura María Torres

    2008-07-01

    Full Text Available Lately, several authors have been analyzing the changes in rural areas triggered by globalization. The concepts of new rurality and pluriactivity have allowed progress along these lines, highlighting the new difficulties facing the most vulnerable sectors. This study explores the transformation of peripheral rural territories in Mendoza (Argentina, particularly those that have been thought of as isolated and traditional. This research develops from a case study, combines quantitative and qualitative methods, and takes the production undertakings happening in those lands as units of analysis. Production and economic situations of the past are compared to those in the present. The tendency toward pluriactivity is here considered as a response to the new conditions, and also as an expression of the process of articulation with the capitalist system.

  6. Stable and strontium isotopic records of molluscan shells, lower jurassic, Cuenca Neuquina, southwestern Mendoza, Argentina

    International Nuclear Information System (INIS)

    The strontium, carbon and oxygen isotopic signal of the past oceans is accurately recorded by authigenic marine minerals such as carbonates, sulfates and phosphates. The variation of these isotope ratios through the geological time is used as a tool in correlating and dating marine sedimentary rocks. Many works have been done concerning to the changes in carbon, oxygen and strontium isotope ratios of different marine successions in the world. These allow the construction of curves of secular variations of the isotope signals with geological time (Jones et al., 1994a, 1994b; Veizer et al., 1999; Jacobsen and Kaufman, 1999). This work presents strontium, carbon and oxygen isotope ratios of Early Jurassic biogenic marine carbonates of Cuenca Neuquina in southwestern Mendoza (au)

  7. Geofisica del cuerpo ultramáfico de la mina Salamanca, provincia de Mendoza

    Directory of Open Access Journals (Sweden)

    J. Kostadinoff

    2004-03-01

    Full Text Available La faja de rocas máficas-ultramáficas de la Cordillera Frontal de Mendoza es considerada como una ofiolita desmembrada. La presencia en las rocas ultramáficas serpentinízadas portadoras de mineralizaciónes de talco, sulfuros polimetálicos y de elementos del grupo del platino (EGP constituyen un atractivo para la realización de prospecciones geofísicas. La metodología de trabajo consistió en medir una red de estaciones geofísicas (gravimetría y magnetometría, en el área de la mina Salamanca. Los resultados permitieron evaluar las reservas de talco y calibrar un modelo de prospección geofísica para los sulfuros polimetálicos presentes en la faja de rocas máficas - ultramáficas de la Cordillera Frontal.

  8. Regional climate change scenarios applied to viticultural zoning in Mendoza, Argentina

    Science.gov (United States)

    Cabré, María Fernanda; Quénol, Hervé; Nuñez, Mario

    2016-09-01

    Due to the importance of the winemaking sector in Mendoza, Argentina, the assessment of future scenarios for viticulture is of foremost relevance. In this context, it is important to understand how temperature increase and precipitation changes will impact on grapes, because of changes in grapevine phenology and suitability wine-growing regions must be understood as an indicator of climate change. The general objective is to classify the suitable areas of viticulture in Argentina for the current and future climate using the MM5 regional climate change simulations. The spatial distribution of annual mean temperature, annual rainfall, and some bioclimatic indices has been analyzed for the present (1970-1989) and future (2080-2099) climate under SRES A2 emission scenario. In general, according to projected average growing season temperature and Winkler index classification, the regional model estimates (i) a reduction of cool areas, (ii) a westward and southward displacement of intermediate and warm suitability areas, and (iii) the arise of new suitability regions (hot and very hot areas) over Argentina. In addition, an increase of annual accumulated precipitation is projected over the center-west of Argentina. Similar pattern of change is modeled for growing season, but with lower intensity. Furthermore, the evaluation of projected seasonal precipitation shows a little precipitation increase over Cuyo and center of Argentina in summer and a little precipitation decrease over Cuyo and northern Patagonia in winter. Results show that Argentina has a great potential for expansion into new suitable vineyard areas by the end of twenty-first century, particularly due to projected displacement to higher latitudes for most present suitability winegrowing regions. Even though main conclusions are based on one global-regional model downscaling, this approach provides valuable information for implementing proper and diverse adaptation measures in the Argentinean viticultural

  9. Geophysical characterization of circular structures in Chubut and Mendoza (Argentina): Impact vs. Volcanism

    Science.gov (United States)

    Prezzi, C.; Orgeira, M. J.; Risso, C.; Acevedo, R.; Ponce, F.; Nullo, F.; Martinez, O.; Rabassa, J.; Margonari, L.; Corbella, H.

    2013-05-01

    This work focuses on two main objectives. One of them is to provide information to discern the genesis of the circular structures present in Bajada del Diablo (Chubut, Argentina) considered as impact craters, and the other one is to contribute to a better knowledge of the circular structures located in the volcanic fields of Llancanelo and Payunia (Mendoza, Argentina). Chubut circular structures have been attributed to the collision of an extraterrestrial body, possibly an asteroid. However, doubts persist about their genesis because of the lack of direct geological evidences. Since detailed geomorphological studies have ruled out an origin by wind deflation, the prevailing alternative hypothesis attributes these circular structures to a volcanic process. On the other hand, the study of the volcanic fields of Payunia and Llancanelo (Mendoza) will contribute to the knowledge of the mechanics of hydromagmatic processes in the area, and the origin of circular structures morphologically similar to those located in Chubut. In the Payunia volcanic field at least 27 cones with evidences of hydromagmatism, in a field of more than 800 pure magmatic cones, have been recognized. This study tries to determine if a relationship between the observed volcanic circular structures and participation of water during the eruption exists. Magnetic and gravity field surveys of the circular volcanic structures in Llancanelo and Payunia volcanic fields were performed in order to determine their relationship with the type of eruption. Electromagnetic, magnetic and gravity field surveys were also carried out in Chubut circular structures. The comparative analysis of geological and geophysical results obtained in the circular structures of Chubut and those obtained in the circular structures in the volcanic areas of Llancanelo and Payunia suggest an impact origin for the circular structures of Chubut.

  10. Diagnosis of GM-1 gangliodosis in Cuba Comportamiento de la GM-1 gangliosidosis en Cuba.

    OpenAIRE

    Alina González-Quevedo Monteagudo; Claudina Zaldívar Muñoz; Sergio González García; Caridad Menéndez Saínz

    2007-01-01

    Background: GM-1 gangliosidosis is included in the group of lysosomal diseases and is characterized by a deficiency of the enzyme b-galactosidase, which as a consequence produces accumulation of GM1 ganglioside in nervous cells and galactosil oligosaccharides and products of keratan sulfate degradation in other tissues. Clinically this disease presents with an early psychomotor impairment, macular cherry red spots, facial dysmorphia, bone deformities and hepatospl...

  11. Minerales de mena del depósito epitermal de baja sulfuración Don Sixto, Mendoza Ore minerals from Don Sixto, a low sulfidation epithermal deposit from Mendoza

    Directory of Open Access Journals (Sweden)

    Ana Cecilia Mugas Lobos

    2012-03-01

    Full Text Available El proyecto minero Don Sixto es un depósito epitermal de baja sulfuración de Au-Ag, ubicado en el bloque de San Rafael, en el SE de la provincia de Mendoza. En este depósito, cuyo recurso aurífero es próximo a las 900.000 onzas, se ha identificado una asociación de minerales de metales preciosos que incluye: uytenbogaardtita, stromeyerita, naumannita, acantita, polibasita, stützita y cervelleita. Estos minerales son escasos y se encuentran frecuentemente asociados a oro y plata de variable fineza, diseminados en vetas de cuarzo hidrotermal y en unidades volcánicas-piroclásticas de los Grupos Choiyoi y El Portillo. En este depósito se encuentra abundante pirita, con cantidades menores de arsenopirita, calcopirita, esfalerita, magnetita, hematita y, en forma subordinada, pirrotina, galena, marcasita, bornita y boulangerita, junto con calcosina, digenita y covellina. La presencia de uytenbogaardtita, stützita, cervelleita y polibasita constituye la primera mención de estos minerales para la provincia de Mendoza.The Don Sixto mining project is a low sulfidation Au-Ag deposit, with a gold resource close to 900,000 ounces, located in the San Rafael Massif, in the SE of Mendoza province. Recently, it was found a precious-metal mineral association including uy-tenbogaardtite, stromeyerite, naumannite, acanthite, polybasite, stützite and cervelleite. These minerals are scarce and are commonly related to gold and silver of variable fineness, disseminated in hydrothermal quartz veins and volcanic-pyroclastic rock units from the Choiyoi and El Portillo Group. The most common mineral is pyrite associated with subordinated arsenopyrite, chalcopyrite, sphalerite, magnetite and hematite; lesser amounts of pyrrhotite, galena, marcasite, bornite, boulangerite, chalcocite, digenite and covellite were also recognized. This is the first mention in Mendoza province for uytenbogaardtite, stützite, cervelleite and polybasite.

  12. The first rodent from the Marino Formation (Miocene) at Divisadero Largo (Mendoza Argentina) and its biochronological implications El primer roedor de la Formación Marino (Mioceno) en Divisadero Largo (Mendoza, Argentina) y sus implicancias biocronológicas

    OpenAIRE

    Esperanza Cerdeño; M. Guiomar Vucetich

    2007-01-01

    A new significant mammal fossil from the Marino Formation in the area of Divisadero Largo (Mendoza, Argentina) is described herein. The material consists of a mandibular fragment with the right series p4-m3 of the rodent Scleromys sp. It is compared with the Santacrucian species S. osbornianus Ameghino and S. angustus Ameghino, and with S. quadrangulatus Kramarz from the Pinturas Formation, all of them from the Santa Cruz Province. At the same time, the studied fossil presents a combination o...

  13. Doña Mencía de Mendoza y su residencia en el Palacio del Real en Valencia

    Directory of Open Access Journals (Sweden)

    Hidalgo Ogáyar, Juana

    2011-03-01

    Full Text Available Documents preserved in the Archivo del Palau reveal the furnishings that Mencía de Mendoza had in the Royal Palace at Valencia, particularly luxury beds such as those of the Empress Isabel of Portugal and Queen Mary of France. Painters active at her court, especially Juan de Bolaños, are also discussed.

    Con la ayuda de varios documentos conservados en el Archivo del Palau, se dan a conocer diferentes enseres que Doña Mencía de Mendoza tenía en el Palacio del Real en Valencia, destacando camas de lujo como la de la Emperatriz Isabel de Portugal o la de María de Francia. Se dan a conocer algunos pintores activos en su corte como Juan de Bolaños.

  14. Environmental and agronomic impact of the herbicide tolerant GM rapeseed

    OpenAIRE

    Zdjelar Gordana R.; Nikolić Zorica T.; Marjanović-Jeromela Ana M.; Jovičić Dušica D.; Ignjatov Maja V.; Petrović Dragana N.

    2011-01-01

    The introduction of genetically modified herbicide tolerant rapeseed has raised questions concerning the possible transfer of transgenes into wild relatives or neighbouring fields with similar crops. Pollen of rapeseed can be spread in the area and if a non-GM crop is fertilised by GM pollen, some percentage of the collected seed product will contain GM. Current regulation in the EU limits the allowed content. For conventional crops the critical level of GM...

  15. Governing the GM crop revolution: policy choices for developing countries

    OpenAIRE

    Paarlberg, Robert L.

    2000-01-01

    Will developing countries adopt policies that promote the planting of genetically modified (GM) crops, or will they select policies that slow the spread of the GM crop revolution? The evidence so far is mixed. In some prominent countries such as China, policies are in place that encourage the independent development and planting of GM crops. Yet in a number of other equally prominent countries the planting of GM crops is not yet officially approved. The inclination of developing countries to ...

  16. Identifying farmer attitudes towards genetically modified (GM) crops in Scotland

    OpenAIRE

    Hall, Clare

    2006-01-01

    Consumer attitudes towards genetically modified (GM) food are well documented but there has been much less focus on farmer attitudes to GM technology in agriculture. This paper reports findings from a study investigating farmers’ attitudes to GM crops in Scotland. Results from a Q methodology study reveal three discourses, one apparently pro-GM and demonstrating an expectation of benefits, the second representing a more uncertain position, wary of the potential risks of the technology but lik...

  17. Epistemological depth in a GM crops controversy.

    Science.gov (United States)

    Hicks, Daniel J

    2015-04-01

    This paper examines the scientific controversy over the yields of genetically modified [GM] crops as a case study in epistemologically deep disagreements. Appeals to "the evidence" are inadequate to resolve such disagreements; not because the interlocutors have radically different metaphysical views (as in cases of incommensurability), but instead because they assume rival epistemological frameworks and so have incompatible views about what kinds of research methods and claims count as evidence. Specifically, I show that, in the yield debate, proponents and opponents of GM crops cite two different sets of claims as evidence, which correspond to two rival epistemological frameworks, classical experimental epistemology and Nancy Cartwright's evidence for use. I go on to argue that, even if both sides of the debate accepted Cartwright's view, they might still disagree over what counts as evidence, because evidence for use ties standards of evidence to what is sometimes called the "context of application."

  18. Safety of GM crops: compositional analysis.

    Science.gov (United States)

    Brune, Philip D; Culler, Angela Hendrickson; Ridley, William P; Walker, Kate

    2013-09-01

    The compositional analysis of genetically modified (GM) crops has continued to be an important part of the overall evaluation in the safety assessment program for these materials. The variety and complexity of genetically engineered traits and modes of action that will be used in GM crops in the near future, as well as our expanded knowledge of compositional variability and factors that can affect composition, raise questions about compositional analysis and how it should be applied to evaluate the safety of traits. The International Life Sciences Institute (ILSI), a nonprofit foundation whose mission is to provide science that improves public health and well-being by fostering collaboration among experts from academia, government, and industry, convened a workshop in September 2012 to examine these and related questions, and a series of papers has been assembled to describe the outcomes of that meeting.

  19. Centralización de la represión, violencia paraestatal y redes internacionales represivas en la Mendoza predictatorial

    Directory of Open Access Journals (Sweden)

    Laura Rodriguez Aguero

    2014-04-01

    Full Text Available Durante el tercer gobierno peronista (1973-1976 comenzó a montarse el dispositivo represivo que marcó los prolegómenos del Terrorismo de Estado llevado adelante por la dictadura militar de 1976. En Mendoza, la violencia paraestatal fue llevada a cabo por el CAM (Comando Anticomunista Mendoza, y el Comando Moralizador Pío XII. En este trabajo nos proponemos realizar a partir del uso de fuentes escritas y del testimonio de algunos/as sobrevivientes, una reconstrucción del accionar paraestatal, en vistas a analizar, por un lado, cómo se constituyeron en la dinámica local, las redes de relaciones implicadas en la práctica represiva y la inflexión que implicó noviembre de 1975 en la centralización de la represión; y por otro lado, cómo se manifestó el carácter internacional de la represión y la idea de aniquilación del “enemigo interno” en Mendoza, partiendo de la hipótesis de que la misma adquirió proporciones inusitadas debido a su carácter de provincia de frontera y su cercanía con Chile, en un momento de articulación de redes represivas en el Cono Sur.

  20. La lacertofauna de Mendoza: lista actualizada, distribución y riqueza

    Directory of Open Access Journals (Sweden)

    Corbalán, Valeria

    2008-04-01

    Full Text Available La provincia de Mendoza posee una rica fauna de lagartos pertenecientes a las familias Leiosauridae, Liolaemidae, Teiidae, Scincidae y Gekkonidae. Algunos son propios del Monte, Puna, Payunia o región andina, mientras que otros poseen una amplia distribución, ocupando dos o más ecosistemas. El objetivo de este trabajo fue actualizar la lista lacertofaunística de la provincia y determinar las áreas de mayor riqueza de especies en relación a estos cuatro tipos de ecosistemas. Se utilizaron datos de procedencia de 43 especies de lagartos a partir de colecciones herpetológicas y de bibliografía. Las localidades fueron georreferenciadas y mapeadas. Una primera estimación de las áreas de mayor riqueza fue realizada sobre la base de las distribuciones de acuerdo a los puntos de colecta. En un segundo análisis, se generaron modelos predictivos de distribución utilizan-do 26 variables ambientales. Estas áreas potenciales fueron superpuestas a fin de obtener el número de especies en cuadrículas de 4,6 km x 4,6 km. Los resultados de ambos métodos indican que la mayor riqueza de especies se encuentra en la Payunia, probablemente en relación a la mayor heterogeneidad ambiental de la zona, ya que es considerada un área ecotonal entre la región fitogeográfica de la Patagonia y el Monte. Un análisis de similitud (Índice de Morisita demuestra que la similitud entre ecosistemas en cuanto a la composición de especies es baja, conformándose dos grupos: el Monte y Patagonia por un lado, y el ecosistema Andino y Puneño por otro. Mendoza province has a rich fauna of lizards that belongs to the Leiosauridae, Liolaemidae, Teiidae, Scincidae and Gekkonidae families. Some of them are typical of the Monte, Puna, Payunia or Andean region, whereas some others are widespread, inhabiting two or more ecosystems. The objective of this work is to perform an updating of the Mendoza lizard fauna and to determine the most highly species-rich areas related to

  1. Mercado de trabajo y condiciones de vida en Mendoza a comienzos del siglo XX

    Directory of Open Access Journals (Sweden)

    Juan Manuel Cerdá

    2006-01-01

    Full Text Available El propósito del presente trabajo es analizar los cambios y las continuidades en el proceso de formación del mercado de trabajo en la provincia de Mendoza a comienzos del siglo XX. La incorporación de un número significativo de inmigrantes a finales del siglo XIX junto a un proceso de reorganización productiva asociado al desarrollo de la industria vitivinícola, implicó cambios en las relaciones sociales y en las condiciones de vida de amplios sectores de la población mendocina. Iniciado el siglo XX, la vitivinicultura se convirtió en la principal actividad productiva de la provincia y la más importante en su rubro a nivel nacional. Los viñateros, productores agroindustriales, industriales bodegueros, contratistas de viñas , etc., fueron constituyéndose en parte de una sociedad cada vez más heterogénea y diversa, producto del desarrollo capitalista que experimentó la región desde el último tercio del siglo XIX y que se insertó en el proceso de incorporación de la economía Argentina al mercado mundial. Este período resulta de suma importancia porque se determinó un sistema productivo en torno a la actividad vitivinícola de la provincia que dio forma al mercado de trabajo regional. En este contexto, la inserción de los trabajadores se dio de una manera muy dispar en el proceso productivo, caracterizado por una alta estacionalidad y una escasa especialización de la mano de obra requerida.The aim of this work is to analyze the changes and continuities during the process of formation of the labor market in the province of Mendoza in the early 1900s. Wide sectors of the Mendoza population saw their life conditions and social interactions change as a result of the absorption of a significant amount of immigrants by the end of 19 th century, together with a restructuring of production connected to the development of the wine industry. Shortly after the turn of the century, wine had become the main productive activity of that

  2. Gm crops: between biological risk and environmental and economic benefits

    International Nuclear Information System (INIS)

    The transgenic crops were the result of the application of recombinant DNA technology in agriculture. These crops were developed by transfer of foreign genes (transgenes) from any biological origin (animal, plant, microbial, viral) to the genome of cultivated species of plants. The crops genetically modified (GM) have been used in the world since 1996; up to December 2010 they counted to a billion hectares planted throughout the period. In just the past year 2010 148 million hectares were planted, grown by 15.4 million farmers in 29 countries. GM crops that are used in global agriculture are mainly soybean, cotton, corn and canola, which express transgenes derived from bacteria, and confer resistance to lepidopteron insects (ILR) or herbicide tolerance (HT; glyphosate and glufosinate ammonium). the first transgenic varieties containing only a single transgene, or simple event, while the current varieties express several transgenes, or stacked, conferring resistance to different species of Lepidoptera and coleopteran insects and tolerance to two different herbicides. In 2010 were planted in Colombia, 18.874 hectares of GM cotton, 16.793 hectares of GM corn, and 4 hectares of GM carnations and GM roses. GM corn and GM cotton were planted in Sucre, Cesar, Cordoba, Huila and Tolima. GM corn was planted in Antioquia, Valle del Cauca, Meta, Cundinamarca and Santander. Carnations and roses were planted in Cundinamarca. GM maize and GM cotton expressing ILR and HT features, as simple events or stacked. In the case of GM carnation and GM roses, these genotypes that express the color blue. Academia has tried to organize the debate on the adoption of GM crops around the analysis of biological risks and environmental vs environmental and economic benefits. Biological hazards are defined by the possible negative effects on human consumers or negative effects on the environment. The environmental benefits are related to reduce use of agrochemicals (insecticides and herbicides

  3. Desarrollo poblacional de Diaspidiotus perniciosus (Hemiptera: Diaspididae en cultivos de manzano de San Carlos, Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Guillermo P. LOPEZ GARCIA

    2011-01-01

    Full Text Available Se estudió la bionomía de Diaspidiotus perniciosus Comstock (“escama de San José”, en manzanos de la variedad “Red delicious” de San Carlos, Mendoza, Argentina, durante los ciclos productivos 2007-2008 y 2008-2009. Se determinó el número de generaciones anuales y se estudiaron las fluctuaciones poblacionales asociadas a la integral térmica para la especie en esta región. D. perniciosus presenta dos generaciones superpuestas al ciclo del cultivo, mientras que las ninfas (N1 y N2 de la tercera generación se desarrollan solamente hasta el final de la temporada estival y pasan al estado de quiescencia, en el que permanecen durante el invierno. El desarrollo de D. perniciosus en esta zona coincide con el de esta especie en la zona frutícola del centro de Chile en cuanto al número de generaciones y al periodo de quiescencia invernal. La población quiescente en Chile está integrada predominantemente por ninfas del primer estadio (N1, mientras que en San Carlos, Mendoza, la población quiescente está integrada principalmente por ninfas del segundo estadio (N2. La similitudes entre ambas poblaciones se deben, probablemente, a las coincidencias en latitud, clima y especie hospedera. El impacto económico de D. perniciosus en la zona de estudio tiene mayor relevancia durante los meses de diciembre y enero, cuando se observa una alta incidencia de daños en los frutos y las hojas; este es el momento decisivo para implementar medidas de control fitosanitario. Estas deberán aplicarse en función de los máximos poblacionales de N1 que se producen con 600-650 Grados-Día (oD en diciembre y con 1.170-1.270oD en enero. En las temporadas en las que la densidad poblacional de la plaga es especialmente alta, podrían incorporarse medidas adicionales de control con 1.800-2.000oD durante el mes de abril. Los resultados de estos estudios representan una herramienta predictiva, que permitirá elaborar estrategias para el control de poblaciones de

  4. Regional climate change scenarios applied to viticultural zoning in Mendoza, Argentina.

    Science.gov (United States)

    Cabré, María Fernanda; Quénol, Hervé; Nuñez, Mario

    2016-09-01

    Due to the importance of the winemaking sector in Mendoza, Argentina, the assessment of future scenarios for viticulture is of foremost relevance. In this context, it is important to understand how temperature increase and precipitation changes will impact on grapes, because of changes in grapevine phenology and suitability wine-growing regions must be understood as an indicator of climate change. The general objective is to classify the suitable areas of viticulture in Argentina for the current and future climate using the MM5 regional climate change simulations. The spatial distribution of annual mean temperature, annual rainfall, and some bioclimatic indices has been analyzed for the present (1970-1989) and future (2080-2099) climate under SRES A2 emission scenario. In general, according to projected average growing season temperature and Winkler index classification, the regional model estimates (i) a reduction of cool areas, (ii) a westward and southward displacement of intermediate and warm suitability areas, and (iii) the arise of new suitability regions (hot and very hot areas) over Argentina. In addition, an increase of annual accumulated precipitation is projected over the center-west of Argentina. Similar pattern of change is modeled for growing season, but with lower intensity. Furthermore, the evaluation of projected seasonal precipitation shows a little precipitation increase over Cuyo and center of Argentina in summer and a little precipitation decrease over Cuyo and northern Patagonia in winter. Results show that Argentina has a great potential for expansion into new suitable vineyard areas by the end of twenty-first century, particularly due to projected displacement to higher latitudes for most present suitability winegrowing regions. Even though main conclusions are based on one global-regional model downscaling, this approach provides valuable information for implementing proper and diverse adaptation measures in the Argentinean viticultural

  5. Impact of GM crops on biodiversity.

    Science.gov (United States)

    Carpenter, Janet E

    2011-01-01

    The potential impact of GM crops on biodiversity has been a topic of interest both in general as well as specifically in the context of the Convention on Biological Diversity. Agricultural biodiversity has been defined at levels from genes to ecosystems that are involved or impacted by agricultural production (www.cbd.int/agro/whatis.shtml). After fifteen years of commercial cultivation, a substantial body of literature now exists addressing the potential impacts of GM crops on the environment. This review takes a biodiversity lens to this literature, considering the impacts at three levels: the crop, farm and landscape scales. Within that framework, this review covers potential impacts of the introduction of genetically engineered crops on: crop diversity, biodiversity of wild relatives, non-target soil organisms, weeds, land use, non-target above-ground organisms, and area-wide pest suppression. The emphasis of the review is peer-reviewed literature that presents direct measures of impacts on biodiversity. In addition, possible impacts of changes in management practises such as tillage and pesticide use are also discussed to complement the literature on direct measures. The focus of the review is on technologies that have been commercialized somewhere in the world, while results may emanate from non-adopting countries and regions. Overall, the review finds that currently commercialized GM crops have reduced the impacts of agriculture on biodiversity, through enhanced adoption of conservation tillage practices, reduction of insecticide use and use of more environmentally benign herbicides and increasing yields to alleviate pressure to convert additional land into agricultural use.

  6. Assessing biosafety of GM plants containing lectins

    DEFF Research Database (Denmark)

    Poulsen, Morten; Pedersen, Jan W.

    2010-01-01

    The introduction of genetic engineering has already shown its benefits in transferring genes into crop plants and conferring resistance towards pests. Most of these crop plants on the market have been transformed with the cry genes from Bacillus species, conferring resistance towards certain...... of the lectins that are potentially useful for insect resistance will pose no health risk in genetically modified (GM) plants. Since some lectins are known for their toxicity to humans, the insertion of lectin genes in food crop plants will have to be assessed carefully. It is expected that in some cases...

  7. GM-CSF signalling boosts dramatically IL-1 production.

    Directory of Open Access Journals (Sweden)

    Hanif Javanmard Khameneh

    Full Text Available GM-CSF is mostly known for its capacity to promote bone marrow progenitor differentiation, to mobilize and mature myeloid cells as well as to enhance host immune responses. However the molecular actions of GM-CSF are still poorly characterized. Here we describe a new surprising facet of this "old" growth factor as a key regulator involved in IL-1β secretion. We found that IL-1β release, a pivotal component of the triggered innate system, is heavily dependent on the signaling induced by GM-CSF in such an extent that in its absence IL-1β is only weakly secreted. GM-CSF synergizes with LPS for IL-1β secretion mainly at the level of pro-IL-1β production via strengthening the NF-κB signaling. In addition, we show that expression of Rab39a, a GTPase required for caspase-1 dependent IL-1β secretion is greatly augmented by LPS and GM-CSF co-stimulation suggesting a potential GM-CSF contribution in enhancing IL-1β exocytosis. The role of GM-CSF in regulating IL-1β secretion is extended also in vivo, since GM-CSF R-/- mice are more resistant to LPS-mediated septic shock. These results identify GM-CSF as a key regulator of IL-1β production and indicate GM-CSF as a previously underestimated target for therapeutic intervention.

  8. CARACTERIZACIÓN ARQUEOMÉTRICA Y TECNOLOGÍA DE PRODUCCIÓN DE CERÁMICA VIDRIADA DE MENDOZA

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    María José Ots

    2013-12-01

    Full Text Available In this paper, a contribution to the archaeometric characterization of colonial pottery of Mendoza province is introduced. It is carried out by microscopic analysis of paste (petrographic and surface treatments (SEM, and by microanalysis (EDS of the composition of glazes. It is proposed to investigate aspects of colonial local production regarding to raw materials provenance, production areas and the skills involved. The results of these analyzes would located the probable sources in the northwest and central west of Mendoza province. On the other hand, from the technological point of view, some features of the operating sequence (crushed of non plastic inclusions, handmade and wheel modeling, glaze applying and two different firings are identified and discussed. These data, together with data provided by other archaeological studies and by historical documentation, allow proposing a revision of the “Carrascal” type as the only colonial pottery class of Mendoza, considering the variety of technical resources used in multiple production centers throughout time.

  9. Hilos de agua, lazos de sangre: enfrentando la escasez en el desierto de Lavalle (Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    L.M. Torres

    2008-01-01

    Full Text Available En el trabajo se analizan las posibles relaciones existentes entre las dinámicas de uso de los recursos naturales y las estrategias de localización de las unidades domésticas en el territorio, dentro de espacios rurales de desierto que poseen una oferta ambiental limitada. ¿Cómo, en el marco de qué estrategias, los grupos humanos convierten distintas porciones de la naturaleza en recurso natural? y ¿cómo usan y administran esos recursos en procura de asegurar su propia reproducción social? Para avanzar en esta dirección se analiza un estudio de caso (el desierto de Lavalle, provincia de Mendoza, Argentina y, dentro de él, se procede con las técnicas cualitativas de entrevista en profundidad y observación participante. Los datos que se presentan sugieren que en los territorios analizados rurales, emplazados en tierras secas, afectados por desertificación y con elevados índices de pobreza- las limitaciones que impone el medio ambiente son sobrellevadas –en alguna medida- mediante una estrategia de localización íntimamente relacionada con el proceso de producción, que maximiza el acceso de determinados recursos naturales y que "ordena" la competencia por ellos con los vecinos y parientes.

  10. Longitudinal Taphonomic Studies of Mammal Carcasses from the Rio Salado Valley, Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Clara Otaola

    2016-02-01

    Full Text Available Taphonomic studies aid in understanding the transition of organic matter from living contexts (the biosphere to geological contexts (the lithosphere, and how agents and processes affect skeletal remains in the archaeological record. Archaeological research in the Atuel River valley, Mendoza, Argentina, has been carried out for several years. However, actualistic approaches to examine local and regional taphonomic processes have only been recently developed in this area. Longitudinal studies of disarticulation and dispersion of bones from carcasses are presented here in order to understand how skeletal materials are naturally added to, subtracted from, and mixed within the archaeological record. In this paper we explore variability in the influence of taphonomic processes in different microhabitats of the valley and how these mechanisms impact the potential of mixing during bone deposition in the archaeological record. There are some qualitative differences between carcasses deposited in different landforms, showing that each place has its own taphonomic history, principally influenced by the geomorphic and ecologic processes that operate in different landforms.

  11. Diseño participativo de espacios urbanos bioclimáticos. Experiencia en Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Claudia Fernanda Martinez

    2015-04-01

    Full Text Available El presente trabajo reconoce los beneficios de las técnicas participativas de diseño para la producción social y sustentable del hábitat, al equilibrar soluciones bioclimáticas con los intereses de los beneficiarios. Como metodología, se aplicaron talleres comunitarios orientados tradicionalmente solo a la vivienda, para el diseño participativo de espacios urbanos conexos y sus redes en un conjunto habitacional de la provincia de Mendoza (Argentina. El desarrollo de talleres de diseño participativo pone de manifiesto la importancia de transferir a la comunidad beneficiaria de planes de vivienda de interés social los conceptos de la arquitectura bioclimática y sus implicaciones en la calidad de vida de las personas, el ahorro energético y la sustentabilidad ambiental. Los resultados indican que es posible conciliar el diseño de espacios urbanos eficientes energética y ambientalmente con cero sobrecosto y que, al mismo tiempo satisfagan las expectativas de los usuarios.

  12. Osteoporosis Self-Assessment Tool Performance in a Large Sample of Postmenopausal Women of Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Fernando D. Saraví

    2013-01-01

    Full Text Available The Osteoporosis Self-assessment Tool (OST is a clinical instrument designed to select patients at risk of osteoporosis, who would benefit from a bone mineral density measurement. The OST only takes into account the age and weight of the subject. It was developed for Asian women and later validated for European and North American white women. The performance of the OST in a sample of 4343 women from Greater Mendoza, a large metropolitan area of Argentina, was assessed. Dual X-ray absorptiometry (DXA scans of lumbar spine and hip were obtained. Patients were classified as either osteoporotic (N=1830 or nonosteoporotic (n=2513 according to their lowest T-score at any site. Osteoporotic patients had lower OST scores (P<0.0001. A receiver operating characteristic (ROC curve showed an area under the curve of 71% (P<0.0001, with a sensitivity of 83.7% and a specificity of 44% for a cut-off value of 2. Positive predictive value was 52% and negative predictive value was 79%. The odds ratio for the diagnosis of osteoporosis was 4.06 (CI95 3.51 to 4.71; P<0.0001. It is concluded that the OST is useful for selecting postmenopausal women for DXA testing in the studied population.

  13. Peritidal cyclic sedimentation from La Manga Formation (Oxfordian), Neuquén Basin, Mendoza, Argentina

    Science.gov (United States)

    Palma, Ricardo M.; Kietzmann, Diego A.; Bressan, Graciela S.; Martín-Chivelet, Javier; López-Gómez, José; Farias, María E.; Iglesias Llanos, María P.

    2013-11-01

    The La Manga Formation consists of marine carbonates and represents most of the sedimentary record of the Callovian-Oxfordian in the Neuquén Basin. Three localities in the southern Mendoza province were studied and their cyclicity was determined by means of facies analysis and their vertical arrangement. Facies of inner ramp, that were deposited in extremely shallow-water environments with intermittent subaerial exposures have been broken down into shallow subtidal, and intertidal-supratidal environments. Shallow subtidal facies are arranged into decimetre scale upward-shallowing cycles composed of marls, laminated or massive mudstones or bioclastic wackestones and intraclastic wackestone-packstones. Intertidal-supratidal centimetre-scale cycles consist of an upward-shallowing succession of restricted facies, overlaid by horizontal or crinkle microbial laminites, flat pebble conglomerates or breccias beds. The defined cycles show a shallowing upward trend in which the evidence of relative sea-level lowering is accepted. The interpretation of Fischer plots allowed the recognition of changes in accommodation space.

  14. El arriero y el transporte terrestre en el Cono Sur (Mendoza, 1780-1800

    Directory of Open Access Journals (Sweden)

    Lacoste, Pablo

    2008-12-01

    Full Text Available This paper explores the muleteer as an economic actor in terrestrial transportation in South Cone, specially in the route across the Andes in order to connect Atlantic and Pacific markets. Since Mendoza’s customs records, this study has processed 120.000 freight-carrying mules to know the origin and destiny places, main routes, volume and kind of charge. The muleteer promoted an intensive activity in terms of transportation, trade and wine industry. As a result, he leaded the rise of a regional proto-bourgeoisie.

    El artículo examina al arriero como actor económico en el transporte terrestre del Cono Sur, sobre todo en la ruta a través de la Cordillera de los Andes, para enlazar los mercados del Atlántico y el Pacífico. A partir de los manuales de Cargo y Data de la Aduana de Mendoza, se han procesado 120.000 mulas de carga para determinar los lugares de origen y destino, principales rutas, volumen y tipo de carga transportada. El arriero impulsó una intensa actividad en el transporte, el comercio y en la industria vitivinícola; como resultado, este actor promovió el surgimiento de una protoburguesía regional.

  15. Paleomagnetism of Upper Triassic rocks in the Los Colorados hill section, Mendoza province, Argentina

    Science.gov (United States)

    Vizán, Haroldo; Ixer, Robert; Turner, Peter; Cortés, José María; Cladera, Gerardo

    2004-12-01

    Different authors have highlighted a systematic disagreement between Late Carboniferous-Triassic paleomagnetic poles (PPs) for Gondwanaland and Laurasia when they are repositioned in a classical reconstruction prior to the breakup of Pangea A. This disagreement has been interpreted in geodynamic terms or as an evidence of non-dipole components of the geomagnetic field. Such analyses have been made using data on South American PPs published approximately 25 years ago and obtained using outdated methodologies. In this article, the authors present new Late Triassic paleomagnetic data from rocks that crop out in the Pre-Andean ranges (Precordillera) of Mendoza province (Argentina). Samples of different lithologies were taken from two limbs of a doubly plunging syncline, and several field tests of paleomagnetic stability were applied. The results indicate primary site mean directions that yield a PP with geographic coordinates and statistical parameters as follows: Lat.=76°S, Lon.=280°E, N=12, R=11.63, α95=8°, K=30.2. This PP agrees with mean PPs of Laurasia of similar ages in different models of Pangea A, indicating that the hypothesis of a dipolar paleomagnetic field could be valid for the Late Triassic.

  16. Darwin's observation in South America: what did he find at agua de la zorra, Mendoza province?

    Directory of Open Access Journals (Sweden)

    Stella Poma

    2009-04-01

    Full Text Available Scarcely 23 km from Uspallata, along the track of the old national highway 7, lies the district of Agua de la Zorra, in Mendoza province in western Argentina. Charles Darwin visited the area during his South American journeys in the 19th century and discovered a geological sequence that contained a paleoflora never described before. The flora includes an important number of species, particularly what is considered a small conifer forest with many silicified trunks still in life position. Darwin described and interpreted the sequence as sedimentary; his records show a very detailed level of observation. He also wondered about the processes that would cause the burial of the paleoflora, which he considered had happened in a marine sedimentary environment. In the modern geological framework and after a detailed study of the rocks containing the trunks, it is now interpreted that the conifer forest was buried by pyroclastic flows. Darwin accurately described the fine volcanic materials as an essential part of the deposit, but the key of the enigma about the origin of the deposits and the burial of the forest is the identification of the pyroclastic flow features; these were unknown process at the time of Darwin´s observations and interpretation.

  17. Projectile motion in Diego Hurtado de Mendoza's Mecánica and new Renaissance dynamics

    Directory of Open Access Journals (Sweden)

    Iommi Echeverría, Virginia

    2011-06-01

    Full Text Available This article considers Diego Hurtado de Mendoza’s translation of the Aristotelian Mechanics in relation to the humanistic and scientific Italian environment of the Renaissance. From the analysis of the last problems on dynamics, it demonstrates the affinity with the works of Piccolomini and Cardano. It also shows the originality of the exegesis made by the Spanish author of Problem XXXIV, in which he combines latemedieval physics with the Aristotelian explanation.Este artículo examina la traducción hecha por Diego Hurtado de Mendoza de la Mecánica aristotélica en el contexto del ambiente científico-humanista italiano de mediados del siglo XVI. A partir del análisis de los últimos problemas sobre dinámica, se demuestra su estrecha relación con las obras de Piccolomini y Cardano; sugiriéndose además la originalidad de la interpretación hecha por el autor español del problema XXXIV basada en la combinación de la física tardomedieval y la explicación aristotélica.

  18. The GM1 and GM2 Gangliosidoses: Natural History and Progress toward Therapy.

    Science.gov (United States)

    Regier, Debra S; Proia, Richard L; D'Azzo, Alessandra; Tifft, Cynthia J

    2016-06-01

    The gangliosidoses are lysosomal storage disorders caused by accumulation of GM1 or GM2 gangliosides. GM1 gangliosidosis has both central nervous system and systemic findings; while, GM2 gangliosidosis is restricted primarily to the central nervous system. Both disorders have autosomal recessive modes of inheritance and a continuum of clinical presentations from a severe infantile form to a milder, chronic adult form. Both are devastating diseases without cure or specific treatment however, with the use of supportive aggressive medical management, the lifespan and quality of life has been extended for both diseases. Naturally occurring and engineered animal models that mimic the human diseases have enhanced our understanding of the pathogenesis of disease progression. Some models have shown significant improvement in symptoms and lifespan with enzyme replacement, substrate reduction, and anti-inflammatory treatments alone or in combination. More recently gene therapy has shown impressive results in large and small animal models. Treatment with FDA-approved glucose analogs to reduce the amount of ganglioside substrate is used as off-label treatments for some patients. Therapies also under clinical development include small molecule chaperones and gene therapy. PMID:27491214

  19. Characterization of Rhizobacteria from field grown Genetically Modified (GM and non-GM maizes

    Directory of Open Access Journals (Sweden)

    Emmanuel Wihkochombom Bumunang

    2014-02-01

    Full Text Available This study was done to examine the rhizobacteria from field grown Genetically Modified (GM maize and its non-GM counterpart. Rhizospheric soil samples were collected at 30 days after sowing (DAS and at post-harvest from two experimental fields in Gauteng, South Africa. Total rhizobacteria (cfu/g in GM and non-GM soil samples was not significantly different across the different media 30 DAS and at post-harvest. Rhizobacterial isolates obtained were biochemically characterized using the analytical profile index. Species of Pseudomonas, Aeromonas, Sphingomonas, Burkholderia, Stenotrophomonas, Achromobacter, Ewingella and Bacillus were screened in vitro for plant growth promoting traits such as, ammonia production, catalase activity, indole acetic acid production, phosphate solubilisation, hydrogen cyanide production and antifungal activity. All the 32 rhizobacterial strains tested in this study were positive for catalase activity, ammonia production and IAA production; 90.6% were positive for phosphate solubilisation, 34.3% for indicate antifungal activity but none for hydrogen cyanide production. These findings contributed to the quest for potential biofertilizers and biocontrol agents for sustainable agriculture.

  20. Pollution trends using bark of morus alba in the cities of buenos aires and mendoza (Argentina Tendências de poluição usando cascas de morus alba nas cidades de buenos aires e mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Patricia Perelman

    2010-06-01

    Full Text Available A comparative study of elements deposited on tree bark was carried out for urban and periurban areas of two of the most important cities in Argentina. The content of Fe, Mg, Al, Mn, Zn, Pb, Ba, Cr, Hg, Cu, Ni, Cd and Sb was determined by inductively coupled plasma atomic emission spectrometry (ICP-OES in Morus alba tree bark collected in the cities of Buenos Aires and Mendoza. The main air pollutants detected in the Buenos Aires urban area were Ba, Cr, Cu and Ni and indicate significative difference from the Mendoza urban and periurban areas. Significantly, higher concentrations of Zn, Ba, Cr and Cu were recorded in the periurban area of the city of Buenos Aires than in Mendoza. Bark samples were strongly influenced by dust and show Al, Fe, Mg and other element accumulations that indicate that soil particles were carried out by wind. Elements like Ba and Zn, commonly linked to traffic emissions, showed the highest concentrations in the Buenos Aires metropolitan area, possibly due to more intensive vehicular traffic. Our results indicated that intensity of vehicular traffic and not city structure is responsible for air pollution.Um estudo comparativo dos elementos depositados nas cascas das árvores foi realizado nas áreas urbanas e na periferia de duas cidades das mais importantes da Argentina. Os índices do Fe, Mg, Al, Mn, Zn, Pb, Ba, Cr, Cu, Ni e do Sb foram determinados pela espectrometria da emissão atômica com plasma acoplado indutivamente (ICP-OES nas cascas da árvore Morus alba, coletados nas cidades de Buenos Aires e Mendoza. Os principais elementos da contaminação do ar detectadas na área urbana de Buenos Aires foram Ba, Cr, Cu e Ni, que indicaram diferenças significativas nas áreas urbanas e na periferia de Mendoza. Uma concentração do Zn, Ba, Cr e do Cu foi achada na periferia da cidade de Buenos Aires, significativamente mais elevada do que em Mendoza. As amostras da casca foram influenciadas fortemente pela poeira e

  1. Geología de la región del Cerro Guanaquero, Río Diamante, Mendoza Geology of Cerro Guanaquero region, Diamante River, Mendoza

    Directory of Open Access Journals (Sweden)

    Federico Fuentes

    2008-03-01

    Full Text Available El estudio realizado presenta nuevos datos sobre un sector poco conocido de la Cordillera Principal de Mendoza, en la alta cuenca del río Diamante en las adyacencias del cerro Guanaquero, y los primeros datos geocronológicos de sus rocas volcánicas. Las unidades geológicas presentes en el área se dividen en cuatro grupos principales: secuencias sedimentarias mesozoicas marinas y continentales intensamente plegadas y falladas; intrusivos y volcanitas intermedias de edad neógena; rocas volcánicas pliocenas a recientes de composición intermedia a básica, y depósitos cuaternarios inconsolidados. El cerro Guanaquero, un estratovolcán pliocuaternario intensamente erosionado por glaciares pleistocenos, con sus 4.841 metros es el rasgo orográfico más prominente. Está constituido esencialmente por andesitas grises porfíricas, piroxénicas a biotíticas. Intercaladas con las coladas andesíticas se presentan depósitos piroclásticos, aglomerados volcánicos, ignimbritas y basaltos. La datación de una andesita por el método K-Ar en roca total arrojó una edad de 1,4 ± 0,1 Ma. La deformación ándica comenzó en forma de una faja plegada y corrida de piel fina, con pliegues por despegue en el sector occidental y por propagación de falla en el oriental. La compresión al oeste de los 69º47´O terminó por invertir la fallas normales del rift mesozoico. A lo largo de este meridiano se encuentra la falla más importante de la región, la que se ha correlacionado con la falla Malargüe, bien desarrollada en latitudes más australes. Esta falla limita la faja plegada y corrida del Aconcagua, de naturaleza epidérmica, y la faja plegada y corrida de Malargüe, controlada por la inversión tectónica del basamento. El volcanismo fue muy intenso en el Plioceno y el Cuaternario, correspondiendo a un período de empinamiento de la placa oceánica subducida, en el que la región ha sido levantada pasivamente. La alta resistencia a la erosión de

  2. Functional analysis of structurally related soybean GmWRKY58 and GmWRKY76 in plant growth and development.

    Science.gov (United States)

    Yang, Yan; Chi, Yingjun; Wang, Ze; Zhou, Yuan; Fan, Baofang; Chen, Zhixiang

    2016-08-01

    WRKY transcription factors constitute a large protein superfamily with a predominant role in plant stress responses. In this study we report that two structurally related soybean WRKY proteins, GmWRKY58 and GmWRKY76, play a critical role in plant growth and flowering. GmWRKY58 and GmWRKY76 are both Group III WRKY proteins with a C2HC zinc finger domain and are close homologs of AtWRKY70 and AtWRKY54, two well-characterized Arabidopsis WRKY proteins with an important role in plant responses to biotic and abiotic stresses. GmWRKY58 and GmWRKY76 are both localized to the nucleus, recognize the TTGACC W-box sequence with a high specificity, and function as transcriptional activators in both yeast and plant cells. Expression of GmWRKY58 and GmWRKY76 was detected at low levels in roots, stem, leaves, flowers, and pods. Expression of the two genes in leaves increased substantially during the first 4 weeks after germination but steadily declined thereafter with increased age. To determine their biological functions, transgenic Arabidopsis plants were generated overexpressing GmWRKY58 or GmWRKY76 Unlike AtWRKY70 and AtWRKY54, overexpression of GmWRKY58 or GmWRKY76 had no effect on disease resistance and only small effects on abiotic stress tolerance of the transgenic plants. Significantly, transgenic Arabidopsis plants overexpressing GmWRKY58 or GmWRKY76 flowered substantially earlier than control plants and this early flowering phenotype was associated with increased expression of several flowering-promoting genes, some of which are enriched in W-box sequences in their promoters recognized by GmWRKY58 and GmWRKY76. In addition, virus-induced silencing of GmWRKY58 and GmWRKY76 in soybean resulted in stunted plants with reduced leaf expansion and terminated stem growth. These results provide strong evidence for functional divergence among close structural homologs of WRKY proteins from different plant species. PMID:27335454

  3. Diagnosis of GM-1 gangliodosis in Cuba Comportamiento de la GM-1 gangliosidosis en Cuba.

    Directory of Open Access Journals (Sweden)

    Claudina Zaldívar Muñoz

    Full Text Available Background: GM-1 gangliosidosis is included in the group of lysosomal diseases and is characterized by a deficiency of the enzyme b-galactosidase, which as a consequence produces accumulation of GM1 ganglioside in nervous cells and galactosil oligosaccharides and products of keratan sulfate degradation in other tissues. Clinically this disease presents with an early psychomotor impairment, macular cherry red spots, facial dysmorphia, bone deformities and hepatosplenomegaly. It has a hereditary autosomic-recessive pattern. Objective: To determine of β-galactosidase acid activity in patients with suspicion of GM-1 gangliosidosis. Methods: From 1986 to 2006, 1851 patients have been received in our laboratory from all the country, of which 851 had the diagnostic impression of GM-1 gangliosidosis. In samples from patients, parents and controls, the activity of leukocyte b-galactosidase was determined by a fluorimetric technique (metilumbelliferil derivatives and leukocyte protein level was determined according to Lowry’s method. Results and conclusions: The diagnosis of GM-1 gangliosidosis was attained in 11 patients, and the enzymatic activity was three times lower in patients with respect to their parents and five times lower with respect to controls. The enzymatic activity was not related with gender or age.
    Fundamento: La GM1 gangliosidosis se encuentra incluida dentro del grupo de las enfermedades lisosomales. Se caracteriza por la deficiencia de la enzima b-galactosidasa, lo cual tiene como consecuencia la acumulación del gangliosido GM1 en células nerviosas y galactosil oligosacáridos y productos de degradación de keratán sulfato en otros tejidos. Clínicamente esta enfermedad se expresa por un temprano deterioro psicomotor, mancha rojo-cereza en la mácula, dismorfia facial, deformidades óseas y hepatoesplenomegalia. Se

  4. Estrés nutricional, hipoplasia y explotación de recursos en el centro sur de Mendoza (Argentina) Nutritional stress, enamel hypoplasia, and resource exploitation in south-central Mendoza

    OpenAIRE

    Paula Novellino; Adolfo Gil

    2007-01-01

    Recientemente, se ha propuesto la existencia de un proceso de intensificación en la explotación de recursos para el alto valle del río Atuel durante los últimos 2000 años (Neme et al. 2005). Si bien se han registrado cambios similares en el resto del sur de Mendoza, han surgido algunos cuestionamientos sobre el reflejo arqueológico del mismo (Borrero 2002). Hasta el momento, la discusión de este problema había sido abordada desde el registro arqueofaunístico y desde los patrones de asentamien...

  5. Seeds of Doubt: North American farmers' experiences of GM crops

    OpenAIRE

    Warwick, Hugh; Meziani, Gundula

    2002-01-01

    The picture the biotechnology industry has painted of GM crops in North America is one of unqualified success, after six years of commercial growing. The objective of this report was to assess whether this image is accurate and if not what problems have occurred. We present interviews with North American farmers about their experiences of GM soya, maize and oilseed rape, and review of some of the independent research. The evidence we have gathered demonstrates that GM food crops are far f...

  6. GM Crops, Organic Agriculture and Breeding for Sustainability

    OpenAIRE

    Salvatore Ceccarelli

    2014-01-01

    The ongoing debate about the use of genetically-modified (GM) crops in agriculture has largely focused on food safety and genetic contamination issues. Given that the majority of GM crops have been produced to respond to the problem of crop yield reductions caused by diseases, insects and weeds, the paper argues that in those cases, the currently used GM crops are an unstable solution to the problem, because they represent such a strong selection pressure, that pests rapidly evolve resistance...

  7. Are U.S. Consumers Tolerant of GM Foods?

    OpenAIRE

    Rousu, Matthew; Huffman, Wallace; Shogren, Jason F.; Tegene, Abebayehu

    2002-01-01

    Genetically modified (GM) foods have caused many controversies. One important controversy relates to tolerance?the impurity rate that is tolerated before a commodity must be labeled as genetically modified. Currently, the United States does not have a specific tolerance or threshold level for GM foods. This paper uses experimental auctions to determine consumers? acceptance of non-GM foods with zero, 1 percent, and 5 percent tolerance for genetically modified material. Our results indicate th...

  8. Precaution and Protectionism: GM Food and the WTO

    OpenAIRE

    Rigby, Dan; Burton, Michael P.; Young, Trevor

    2005-01-01

    The dispute between the US and EU over GM foods at the WTO is examined in terms of the issues it raises about protectionism and environmental protection and precaution. The issue of whether GM, GM Derived and Non-GM foods are equivalent to each other is examined using data from a national choice modelling study in the UK. These categories of food are critical since they underpin the EU's new food labelling regime which it hoped would defuse the WTO dispute. The results are analysed using a Ba...

  9. Precaution and Protectionism: 'Likeness' and GM Food at the WTO

    OpenAIRE

    Rigby, Dan; Burton, Michael P.; Young, Trevor

    2006-01-01

    The dispute between the US and EU over GM foods at the WTO is examined in terms of the issues it raises about protectionism, environmental protection and precaution. The issue of whether GM, GM Derived and Non-GM foods are equivalent to each other is examined using data from a national choice modelling study in the UK. These categories of food are critical since they underpin the EU's new food labelling regime which it hoped would defuse the WTO dispute. The results are analysed using a Bayes...

  10. Forecasting the Feasibility of Implementing Isolation Perimeters Between GM and non-GM Maize Fields Under Agricultural Conditions

    Science.gov (United States)

    Devos, Yann; Cougnon, Mathias; Thas, Olivier; De Clercq, Eva M.; Cordemans, Karl; Reheul, Dirk

    2008-10-01

    Although spatially isolating genetically modified (GM) maize fields from non-GM maize fields is a robust on-farm strategy to keep the adventitious presence of GM material in the harvests of neighboring non-GM maize fields due to cross-fertilizations below established labeling thresholds (and thus to ensure the spatial co-existence between maize cropping systems), the practical implementation of isolation perimeters attracted little research efforts. In this study, the feasibility of implementing isolation perimeters around GM maize fields is investigated. Using Geographic Information System datasets and Monte Carlo simulations, various scenarios differing in shares and spatial distributions of GM maize were tested for various isolation perimeters in six agricultural areas in Flanders. Factors that affect the feasibility of implementing isolation perimeters are discussed.

  11. Municipio, identidad cultural y comunidades indígenas. El caso huarpe en el noreste de Mendoza

    OpenAIRE

    Leticia Saldi

    2013-01-01

    En el presente artículo analizamos cómo funcionarios de la Municipalidad de Lavalle representan e interpelan a las comunidades indígenas huarpe situadas en el área no irrigada del noreste de Mendoza, área situada en el departamento de Lavalle. Éste se encuentra dividido socioterritorialmente en dos espacios. Uno irrigado, caracterizado como área de progreso, de producción agrícola y de herencia europea y el otro no irrigado, representado como área de atraso, de producción ganadera y de herenc...

  12. TALE nucleases and next generation GM crops.

    Science.gov (United States)

    Mahfouz, Magdy M; Li, Lixin

    2011-01-01

    Site-specific and adaptable DNA binding domains are essential modules to develop genome engineering technologies for crop improvement. Transcription activator-like effectors (TALEs) proteins are used to provide a highly specific and adaptable DNA binding modules. TALE chimeric nucleases (TALENs) were used to generate site-specific double strand breaks (DSBs) in vitro and in yeast, Caenorhabditis elegans, mammalian and plant cells. The genomic DSBs can be generated at predefined and user-selected loci and repaired by either the non-homologous end joining (NHEJ) or homology dependent repair (HDR). Thus, TALENs can be used to achieve site-specific gene addition, stacking, deletion or inactivation. TALE-based genome engineering tools should be powerful to develop new agricultural biotechnology approaches for crop improvement. Here, we discuss the recent research and the potential applications of TALENs to accelerate the generation of genomic variants through targeted mutagenesis and to produce a non-transgenic GM crops with the desired phenotype.

  13. TALE nucleases and next generation GM crops.

    KAUST Repository

    Mahfouz, Magdy M.

    2011-04-01

    Site-specific and adaptable DNA binding domains are essential modules to develop genome engineering technologies for crop improvement. Transcription activator-like effectors (TALEs) proteins are used to provide a highly specific and adaptable DNA binding modules. TALE chimeric nucleases (TALENs) were used to generate site-specific double strand breaks (DSBs) in vitro and in yeast, Caenorhabditis elegans, mammalian and plant cells. The genomic DSBs can be generated at predefined and user-selected loci and repaired by either the non-homologous end joining (NHEJ) or homology dependent repair (HDR). Thus, TALENs can be used to achieve site-specific gene addition, stacking, deletion or inactivation. TALE-based genome engineering tools should be powerful to develop new agricultural biotechnology approaches for crop improvement. Here, we discuss the recent research and the potential applications of TALENs to accelerate the generation of genomic variants through targeted mutagenesis and to produce a non-transgenic GM crops with the desired phenotype.

  14. GM2 gangliosidosis in British Jacob sheep.

    Science.gov (United States)

    Wessels, M E; Holmes, J P; Jeffrey, M; Jackson, M; Mackintosh, A; Kolodny, E H; Zeng, B J; Wang, C B; Scholes, S F E

    2014-01-01

    GM2 gangliosidosis (Tay-Sachs disease) was diagnosed in 6- to 8-month-old pedigree Jacob lambs from two unrelated flocks presenting clinically with progressive neurological dysfunction of 10 day's to 8 week's duration. Clinical signs included hindlimb ataxia and weakness, recumbency and proprioceptive defects. Histopathological examination of the nervous system identified extensive neuronal cytoplasmic accumulation of material that stained with periodic acid--Schiff and Luxol fast blue. Electron microscopy identified membranous cytoplasmic bodies within the nervous system. Serum biochemistry detected a marked decrease in hexosaminidase A activity in the one lamb tested, when compared with the concentration in age matched controls and genetic analysis identified a mutation in the sheep hexa allele G444R consistent with Tay-Sachs disease in Jacob sheep in North America. The identification of Tay-Sachs disease in British Jacob sheep supports previous evidence that the mutation in North American Jacob sheep originated from imported UK stock. PMID:24309906

  15. Teradiode's high brightness semiconductor lasers

    Science.gov (United States)

    Huang, Robin K.; Chann, Bien; Burgess, James; Lochman, Bryan; Zhou, Wang; Cruz, Mike; Cook, Rob; Dugmore, Dan; Shattuck, Jeff; Tayebati, Parviz

    2016-03-01

    TeraDiode is manufacturing multi-kW-class ultra-high brightness fiber-coupled direct diode lasers for industrial applications. A fiber-coupled direct diode laser with a power level of 4,680 W from a 100 μm core diameter, lasers. The fiber-coupled output corresponds to a Beam Parameter Product (BPP) of 3.5 mm-mrad and is the lowest BPP multi-kW-class direct diode laser yet reported. This laser is suitable for industrial materials processing applications, including sheet metal cutting and welding. This 4-kW fiber-coupled direct diode laser has comparable brightness to that of industrial fiber lasers and CO2 lasers, and is over 10x brighter than state-of-the-art direct diode lasers. We have also demonstrated novel high peak power lasers and high brightness Mid-Infrared Lasers.

  16. The EUVE bright source list

    Science.gov (United States)

    Stroozas, B.; Mcdonald, K.; Antia, B.; Mcdonald, J.; Wiercigroch, A.

    1993-01-01

    Initial results for bright extreme ultraviolet sources discovered during the EUVE all-sky and deep ecliptic surveys have been published as a Bright Source List (BSL) and released to the astronomical community with a recent NASA research announcement (NRA 93-OSS-02, Appendix F). This paper describes the data processing software, the EUVE survey data set, and the production of the BSL at the Center for EUV Astrophysics. The contents, format, and selection criteria for sources, the data processing strategy, some problems encountered, and a summary of the BSL results are presented.

  17. All things bright and beautiful

    OpenAIRE

    Brown, Chloe

    2012-01-01

    'All Things Bright and Beautiful' was exhibited in 20/21 Visual Arts Centre, Scunthorpe, which is sited in a 'redundant' church. The fundamental question that the exhibition explored concerned the role of 'the animal' within contemporary art and within secular society, which in turn hoped to prompt reflections on our understanding of the place of 'the human' in the world and in nature. If there is no divine order, as posited by the hymn 'All Things Bright and Beautiful', where does this leave...

  18. A Quantitative Method to Estimate Vulnerability. Case Study: Motozintla de Mendoza, Chiapas

    Science.gov (United States)

    Rodriguez, F.; Novelo-Casanova, D. A.

    2011-12-01

    The community of Motozintla de Mendoza is located in the State of Chiapas, México (15' 22' N and 92' 15' W) near to the international border with Guatemala. Due to its location, this community is continuously exposed to many different hazards. Motozintla has a population of 20,000 inhabitants. This community suffered the impact of had two disasters recently. In view of these scenarios we carried out the present research with the objective quantifying the vulnerability of this community. We prepared a tool that allow us to document the physical vulnerability conducting interviews with people in risk situation. Our tool included the analysis of five elements: household structure and public services, socioeconomic characteristics, community preparation for facing a disaster situation, and risk perception of the inhabitants using a sample statistically significant. Three field works were carried out (October and November 2009, and October 2010) and 444 interviews were registered. Five levels of vulnerability were considered: very high, high, middle, moderate and low. Our region of study was classified spatially and the different estimated levels of vulnerability were located in geo referenced on maps. Our results indicate that the locality has a high level of physical vulnerability because about 74% of the population reports that their household had suffered damages in the past; 86% of the households present low resistance building materials; 70% of the interviewed families has a daily income under five to fifteen dollars; 66% of population does not know any existing Civil Protection Plan; 83% of the population considers that they live in a high level of risk due to floods; finally, the community organization is practically nonexistent. In conclusion, the level of vulnerability of Motozintla is high due to the many factors to which is exposed, in addition, to the structural, socioeconomic and cultural characteristics of their inhabitants. Evidently, those elements of

  19. Above-ground wineries and interior thermal stability: traditional and contemporary envelope analysis in Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Carolina Ganem Karlen

    2013-06-01

    Full Text Available El control en el intercambio de flujos energéticos interior-exterior y la inercia térmica de los materiales constructivos son características claves de la envolvente de los edificios de bodegas. Esta situación es particularmente importante en el caso de los edificios construidos sobresuelo en climas con temperaturas diarias y estacionales muy variables. En el caso de que la arquitectura no provea la respuesta adecuada, indefectiblemente se recurre al consumo de energía auxiliar. La bodega S.A., ubicada en Mendoza, Argentina, consume energía auxiliar equivalente a 2.500 kW por año. Dicha bodega sobresuelo presenta dos tipos de envolvente vertical: una tradicional en adobe (λ = 0.81W/mK y otra contemporánea en chapa galvanizada sin aislación (λ = 45 W/mK. El objetivo de este trabajo es analizar los aspectos de materialidad, inercia térmica e intercambio de flujos energéticos de envolventes tradicionales y contemporáneas y, comparar los resultados obtenidos con un caso teórico de bodega subterránea. Entre los resultados obtenidos se observa que la envolvente tradicional mantiene las temperaturas interiores entre 8,5 ºC y 10 ºC por debajo de las temperaturas exteriores, mientras que los nuevos espacios con envolventes contemporáneas lo hacen solamente 3 ºC a 5 ºC por debajo de las temperaturas exteriores. En el caso de una bodega subterránea, las temperaturas estarían estables durante el año en 16,5 ºC; esto es, en verano, 20 ºC por debajo de las temperaturas exteriores.

  20. La doctrina sobre el poder del príncipe en Alfonso Hojeda de Mendoza

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    Salustiano de DIOS

    2009-12-01

    Full Text Available RESUMEN: Alfonso Hojeda fue un notable canonista sevillano que en 1576 publicó en Venecia un libro acerca de los beneficios eclesiásticos. La obra se divide en dos partes: la primera está dedicada a argumentar en contra de la pluralidad de beneficios en una misma persona, de acuerdo con los decretos tridentinos de reforma, mientras la segunda trata en cambio de la compatibilidad de beneficios mediante dispensa papal. Los propios términos en que se manifiestan las dos partes ya están indicando las contradicciones en que ha de moverse el autor, difíciles de salvar. La doctrina de la causa es, además de la distinción entre órdenes normativos, la principal herramienta conciliatoria para Hojeda. El papa está desligado del derecho positivo o humano, pues de otro modo no podría dispensar, o privilegiar, mas sólo puede hacerlo con justa causa.ABSTRACT: Alfonso Hojeda de Mendoza was an outstanding canonist that in 1576 published a book in Venice on the eclesiástica benefits. The book is divided into two parts: the first one is devoted to argue against the plurality of benefits in the same person, according to Trento's decrees, while the second one deals, however, with the compatibility of benefits by the Pope's dispense. The own terms in which both parts are expressed reveal the contradictions, in which the author must move, always difficult to avoid. The doctrine of the cause, as well as the distinction among normative orders, is the main conciliatory tool for Hojeda. The Pope is unlinked to human or positive right, otherwise he could not dispense or privilege, however he can only do it for a just cause.

  1. Controles estatales a la industria del vino en Mendoza, 1890-1914

    Directory of Open Access Journals (Sweden)

    PATRICIA BARRIO DE VILLANUEVA

    2013-05-01

    Full Text Available El artículo estudia los controles del Estado nacional y provincial a la agroindustria mendocina del vino entre la década de 1890 y 1914. En este período se detectan dos momentos. En el primero, entre 1890 y 1904, se analiza el mercado de vinos y cómo el Estado nacional utilizó los impuestos (aduaneros e internos para proteger a la naciente industria. También se reconstruye la legislación nacional y provincial que reguló la producción, la comercialización y el cobro de los impuestos al vino; y los mecanismos utilizados por ambas jurisdicciones para el cumplimiento de dichas leyes. En el segundo, se examinan los cambios ocurridos en la vitivinicultura durante los años de auge, entre 1904 y 1912, cuando los Estados provincial y nacional desplegaron estrictas normativas para evitar el fraude vínico y el pago del impuesto; y las primeras medidas tomadas con la llegada de una nueva crisis, entre 1913 y 1914. Abstract The article examines the controls of the national and provincial state to agribusiness Mendoza wine between the 1890 and 1914. In this period two points are detected. In the first, between 1890 and 1904, analyzes the wine market and how the national government used taxes (customs and internal to protect the nascent industry. Also reconstructs the national and provincial legislation that regulates the production, marketing and collection of taxes on wine, and the mechanisms used by both jurisdictions to comply with such laws. The second examines changes in the wine industry during the boom years between 1904 and 1912, when provincial and national States deployed strict standards to prevent wine fraud and tax payments, and the first steps taken with the arrival of a new crisis between 1913 and 1914.

  2. Integrating insect-resistant GM Crops in pest management systems

    Science.gov (United States)

    In 2006, GM cotton and maize with insect resistance were grown on 12.1 and 20.1 million hectares in 9 and 13 countries, respectively. These insect resistant GM crops produce various Cry toxins from Bacillus thuringiensis (Bt) and provide highly selective and effective control of lepidopteran and col...

  3. Anti-GM-CSF antibodies in paediatric pulmonary alveolar proteinosis

    OpenAIRE

    Latzin, P; Tredano, M.; Wust, Y; J. de Blic; Nicolai, T; Bewig, B; Stanzel, F.; Kohler, D.; Bahuau, M.; Griese, M

    2005-01-01

    Background: Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of anti-GM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear.

  4. Bright Transients discovered by PSST

    Science.gov (United States)

    Smith, K. W.; Wright, D.; Smartt, S. J.; Young, D. R.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-08-01

    Six bright transients have been discovered as part of the Pan-STARRS Survey for Transients (PSST). Information on all objects discovered by the Pan-STARRS Survey for Transients is available at http://star.pst.qub.ac.uk/ps1threepi/ (see Huber et al. ATel #7153).

  5. Consumers’ perceptions on GM food safety in urban China

    Institute of Scientific and Technical Information of China (English)

    HUANG Ji-kun; PENG Bo-wen

    2015-01-01

    The debate about the safety of geneticaly modiifed (GM) food has attracted public attention in concurrence with the rapid development of agricultural biotechnology. This paper examines the consumers’ perceptions on the safety of GM food in China. Based on a unique survey dataset, this study shows that consumers in urban China have signiifcantly changed their perceptions on GM food safety. The percentage of consumers who perceived such food as unsafe for consumption increased by more than 30% in the 2002–2012 period. Approximately half of the consumers did not have an opinion on this issue. Major shifts have been occurred after 2010, likely because of the increasing inlfuence of negative media reports on GM technology in recent years. Several individual and household’s characteristics are shown to signiifcantly affect consumers’ perceptions on GM food safety, such as gender, education, food alergy experience and resident city size. The paper concludes with policy implications.

  6. Environmental and agronomic impact of the herbicide tolerant GM rapeseed

    Directory of Open Access Journals (Sweden)

    Zdjelar Gordana R.

    2011-01-01

    Full Text Available The introduction of genetically modified herbicide tolerant rapeseed has raised questions concerning the possible transfer of transgenes into wild relatives or neighbouring fields with similar crops. Pollen of rapeseed can be spread in the area and if a non-GM crop is fertilised by GM pollen, some percentage of the collected seed product will contain GM. Current regulation in the EU limits the allowed content. For conventional crops the critical level of GM contamination is in practice below 0.9%, which is the threshold value for labelling of GM in food and feed by the EU, although the limit for seeds is 0.1% in Serbia. In organic farming, the regulations do not allow the use of genetic engineering in the grain production system.

  7. Subduction controls on Miocene back-arc lavas from Sierra de Huantraico and La Matancilla, Argentina and new 40Ar/39Ar dating from the Mendoza Region, Argentina

    DEFF Research Database (Denmark)

    Dyhr, Charlotte Thorup; Holm, Paul Martin; Llambias, Eduardo J.;

    2013-01-01

    Back-arc volcanism in the western Argentinian provinces of Mendoza and Neuquén has been widespread from the Miocene to historic times. We present a detailed investigation of profiles through two of the major Miocene volcanic areas of the region, the neighboring Huantraico and LaMatancilla plateau...

  8. The impact of different cooling strategies on urban air temperatures: the cases of Campinas, Brazil and Mendoza, Argentina

    Science.gov (United States)

    Alchapar, Noelia Liliana; Cotrim Pezzuto, Claudia; Correa, Erica Norma; Chebel Labaki, Lucila

    2016-07-01

    This paper describes different ways of reducing urban air temperature and their results in two cities: Campinas, Brazil—a warm temperate climate with a dry winter and hot summer (Cwa), and Mendoza, Argentina—a desert climate with cold steppe (BWk). A high-resolution microclimate modeling system—ENVI-met 3.1—was used to evaluate the thermal performance of an urban canyon in each city. A total of 18 scenarios were simulated including changes in the surface albedo, vegetation percentage, and the H/W aspect ratio of the urban canyons. These results revealed the same trend in behavior for each of the combinations of strategies evaluated in both cities. Nevertheless, these strategies produce a greater temperature reduction in the warm temperate climate (Cwa). Increasing the vegetation percentage reduces air temperatures and mean radiant temperatures in all scenarios. In addition, there is a greater decrease of urban temperature with the vegetation increase when the H/W aspect ratio is lower. Also, applying low albedo on vertical surfaces and high albedo on horizontal surfaces is successful in reducing air temperatures without raising the mean radiant temperature. The best combination of strategies—60 % of vegetation, low albedos on walls and high albedos on pavements and roofs, and 1.5 H/W—could reduce air temperatures up to 6.4 °C in Campinas and 3.5 °C in Mendoza.

  9. Analisis morfológico de anfíbioles en menas de talco de la provincia de Mendoza

    Directory of Open Access Journals (Sweden)

    Leticia Lescano

    2013-09-01

    Full Text Available Si bien existen antecedentes de estudios realizados en los yacimientos de talco del distrito minero Salamanca en la provincia de Mendoza, en su mayoría están relacionados con la génesis, estructura y emplazamiento geológico. En varios de ellos se menciona la presencia de serpentina y anfíboles, en las rocas de caja y en las menas. Estos últimos fueron determinados por sus características mineralógicas y propiedades ópticas, pero no han sido evaluados desde el punto de vista de su influencia en los pasivos ambientales de las escombreras, considerando principalmente la dispersión en el ambiente exógeno. Durante años la minería de talco en la provincia de Mendoza fue muy importante, realizada principalmente en forma subterránea. El personal estuvo expuesto al polvo generado durante la explotación, constituido por material particulado, parte de él de morfología asbestiforme. El objeto del presente trabajo es estudiar la morfología de los anfíboles del distrito minero Salamanca y la influencia de su degradación por procesos exógenos naturales y/o por los tratamientos en planta. Se evalúa desde el punto de vista del riesgo que representan para la salud humana.

  10. El temprano desarrollo de la vitivinicultura en Mendoza y en Canelones (1870-1930. Un análisis comparado

    Directory of Open Access Journals (Sweden)

    Daniele Bonfanti

    2005-01-01

    Full Text Available Starting from the end of XIX century, wine producing was a decisive factor in the process of modernization of Rio de la Plata area, contributing in differentiating the production and causing a fast industrialization in this particular field. Besides, local economies were revitalized by inserting them as specialized production areas in the national market. This article represents a first attempt of comparative analysis of the development of this field in two of the main wine producing areas in Rio de la Plata region: the Canelones department (Uruguay and Mendoza province (Argentine.A partir de finales del siglo XIX, la vitivinicultura cumplió un rol determinante en el proceso de modernización rioplatense contribuyendo a la diferenciación de la producción y provocando una rápida industrialización de un sector agrícola. Además, revitalizó a las economías locales, que se reinsertaron en los mercados nacionales como zonas especializadas. El artículo representa un primer intento de análisis comparativo del desempeño del sector en las dos principales áreas vitivinícolas rioplatenses: el departamento de Canelones (Uruguay y la provincia de Mendoza (Argentina.

  11. GM foods: is there a way forward?

    Science.gov (United States)

    Jones, Huw D

    2015-08-01

    There are many quality targets in cereals that could generate step-change improvements in nutritional or food-processing characteristics. For instance, levels of acrylamide, soluble and insoluble fibre, antioxidants, allergens and intolerance factors in food are, to a large extent, determined by the genetics of the raw materials used. However, improvements to these traits pose significant challenges to plant breeders. For some traits, this is because the underlying genetic and biochemical basis of the traits is not fully understood but for others, there is simply a lack of natural genetic variation in commercially useful germplasm. One strategy to overcome the latter hindrance is to use wide crosses with more exotic germplasm; however, this can bring other difficulties such as yield loss and linkage drag of deleterious alleles. As DNA sequencing becomes cheaper and faster, it drives the research fields of reverse genetics and functional genomics which in turn will enable the incorporation of desirable traits into crop varieties via molecular breeding and biotechnology. I will discuss the evolution of these techniques from conventional genetic modification to more recent developments in targeted gene editing and the potential of biotechnology to complement conventional breeding methods. I will also discuss the role of risk assessment and regulation in the commercialisation of GM crops. PMID:26186672

  12. Helmholtz bright and boundary solitons

    Energy Technology Data Exchange (ETDEWEB)

    Christian, J M [Joule Physics Laboratory, School of Computing, Science and Engineering, Institute for Materials Research, University of Salford, Salford M5 4WT (United Kingdom); McDonald, G S [Joule Physics Laboratory, School of Computing, Science and Engineering, Institute for Materials Research, University of Salford, Salford M5 4WT (United Kingdom); Chamorro-Posada, P [Departmento de TeorIa de la Senal y Comunicaciones e IngenierIa Telematica, Universidad de Valladolid, ETSI Telecomunicacion, Campus Miguel Delibes s/n, 47011 Valladolid (Spain)

    2007-02-16

    We report, for the first time, exact analytical boundary solitons of a generalized cubic-quintic nonlinear Helmholtz (NLH) equation. These solutions have a linked-plateau topology that is distinct from conventional dark soliton solutions; their amplitude and intensity distributions are spatially delocalized and connect regions of finite and zero wave-field disturbances (suggesting also the classification as 'edge solitons'). Extensive numerical simulations compare the stability properties of recently derived Helmholtz bright solitons, for this type of polynomial nonlinearity, to those of the new boundary solitons. The latter are found to possess a remarkable stability characteristic, exhibiting robustness against perturbations that would otherwise lead to the destabilizing of their bright-soliton counterparts.

  13. GPM Intercalibrated Radiometer Brightness Temperatures

    Science.gov (United States)

    Stocker, Erich Franz; Chou, Joyce

    2013-04-01

    One of the keys to consistent precipitation retrieval from passive microwave radiometer measurements (whether imagers or sounders) is accurate, long-term consistent brightness temperature retrievals. This becomes doubly important when there measurements are taken from radiometers on multiple platforms, from multiple agencies, with many different purposes. The Global Precipitation Measurement (GPM) mission addresses this issue directly with the production of intercalibrated brightness temperatures from all the partner satellites contributing to the GPM mission. These intercalibrated brightness temperatures are given the product designation: 1C within GPM. This paper will describe the GPM approach to intercalibration 1C products. The intercalibration and creation of the products uses a 5-step methodology: comparison of the partner standard products (either Tb or Ta) with the GPM reference standard; determination of adjustments that should be made to each product to create consistent brightness temperatures; re-orbitization of all orbits (in non-realtime) to be in the standard GPM south-south orbit; application of the adjustments to the partner provide 1B(or 1A) products; production of 1C products in HDF5 using a "standard" logical format for any radiometer regardless of its 1B format. This paper describes each of these steps and provides the background for them. It discusses in some detail the current 1C logical format and why this format facilitates use by downstream product algorithms and end-users. Most importantly it provides the analysis approach established by the GPM inter-calibration working group in establishing the adjustments to be made at the 1C level. Finally, using DMSP F16-18, it provides examples of the 1C products and discusses the adjustments that are made.

  14. Bright solitons from defocusing nonlinearities

    OpenAIRE

    Borovkova, Olga V.; Kartashov, Yaroslav; Torner Sabata, Lluís; Malomed, Boris A.

    2011-01-01

    We report that defocusing cubic media with spatially inhomogeneous nonlinearity, whose strength increases rapidly enough toward the periphery, can support stable bright localized modes. Such nonlinearity landscapes give rise to a variety of stable solitons in all three dimensions, including one-dimensional fundamental and multihump states, two-dimensional vortex solitons with arbitrarily high topological charges, and fundamental solitons in three dimensions. Solitons maintain their coherence ...

  15. Research and transference of the ICES over Malargue, Mendoza, uranium bioremediation

    International Nuclear Information System (INIS)

    The origin of the International Center for Earth Sciences (ICES) dates back to 2002 when the Acoustic Emission Station on Volcano Peteroa was installed. Up to now, it represents the first of its kind in the entire Andean Cordillera. This scientific activity is jointly coordinated by scientists from Italy and Argentina. At the First Conference on Acoustic Emission held on 2004, a letter of intent for the establishment of ICES was signed. Presently, ICES is composed by 4 departments: Environment and Climate; Anthropology; Environmental and Territorial Environmental Risk; Resources and Exploration Geophysics. One of the primary objectives of ICES is to promoting applied research and development in the broad field of Earth Sciences. The experimental work consists of main 4 steps listed below: The 'Helianthus annus' (sunflower) has proven its ability to raise Uranium (U) in hydroponic systems and was widely used in the model U rizophyiltration extraction of groundwater in Ashtabula, Ohio, USA. Hydroponic trial design consists of 6 treatments and 4 repetitions plants witnesses without minimum level of U, U witnesses plants without and 4 with various levels of U (Stage 1). The Glomus intraradices is a mycorrhizal fungus used in strategies of U phyto-stabilization. Test consists in the cultivation of sunflower with roots inoculated with Glomus intraradices to determine their uptake and translocation of U (Stage 2). The inoculation of 'Glomus intraradices' in 'Helianthus annus' produces an effective symbiosis with the type of strain and its genetic diversity, some genotypes are highly suitable for this. There have been experiences of this kind in the basic research in several countries. In this work, we use the system in 'Helianthus-Glomus' phyto-stabilization or rizophyiltration soil as a strategy for bioremediation of U at the Malargue area, Province of Mendoza (Stage 3). It will launch a pilot test of the transfer plan, which involves creating a garden for the growth of

  16. High brightness semiconductor lasers with reduced filamentation

    DEFF Research Database (Denmark)

    McInerney, John; O'Brien, Peter.; Skovgaard, Peter M. W.;

    1999-01-01

    High brightness semiconductor lasers have applications in spectroscopy, fiber lasers, manufacturing and materials processing, medicine and free space communication or energy transfer. The main difficulty associated with high brightness is that, because of COD, high power requires a large aperture...

  17. Emerging Markets for GM Foods: A Study of Consumer's Willingness to Pay in India

    OpenAIRE

    Deodhar, Satish Y.; Ganesh, Sankar; Chern, Wen S.

    2008-01-01

    A random utility approach is used to estimate logit equations which indicate what factors affect the likelihood of consumption of non-GM and GM foods, and, whether or not consumers are willing to pay a premium for non-GM/GM foods. Ceteris paribus as the price difference between non-GM and GM food rose, people were more likely to consume GM foods. Likelihood of GM food consumption was higher in the middle income brackets. Consumers were willing to pay an expected premium of 19.5% and 16.12% fo...

  18. High-brightness rf linear accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, R.A.

    1986-01-01

    The issue of high brightness and its ramifications in linacs driven by radio-frequency fields is discussed. A history of the RF linacs is reviewed briefly. Some current applications are then examined that are driving progress in RF linacs. The physics affecting the brightness of RF linacs is then discussed, followed by the economic feasibility of higher brightness machines. (LEW)

  19. Efectos del Barrio La Gloria: Experiencias del lugar y estrategias simbólicas de los sectores populares en el Gran Mendoza Efeitos do "Barrio de La Gloria": As experiências do lugar e estratégias simbólicas das classes populares na Grande Mendoza Effects of "Barrio La Gloria": The "experience of place" and symbolic strategies of the popular classes in the Greater Mendoza

    Directory of Open Access Journals (Sweden)

    Magdalena Tosoni

    2011-12-01

    Full Text Available En este artículo describo las transformaciones en el espacio urbano y su relación con las desigualdades sociales y simbólicas en el Gran Mendoza. Las políticas de vivienda y los cambios en el mercado inmobiliario promovieron la suburbanización de los sectores populares y la jerarquización del territorio durante los últimos treinta años. A partir de un estudio de caso sobre el Barrio La Gloria ubicado en el sudeste del municipio de Godoy Cruz describo las " experiencias dellugar", es decir, cómo viven las desigualdades materiales y simbólicas los habitantes de un barrio popular del Gran Mendoza, y analizo las estrategias que ensayan las organizaciones para acumular capital simbólico en un área sentida como insegura por sus habitantes y calificada de "peligrosa" por la prensa.Neste artigo vou abordar as transformações no espaço urbano e os usos do local por setores populares e suas organizações na Grande Mendoza. As políticas de habitação e mudanças no mercado imobiliário têm promovido a suburbanização da classes média e popular, e da hierarquia dos territórios. A partir de um estudo de caso do Bairro La Gloria localizado na municipalidade de Godoy Cruz descrever a "experiência do lugar", ou seja, como vivem material e simbólica das desigualdades pessoas em cidade de Mendoza e analisar estratégias que as organizações de teste para acumular capital simbólico em uma área se sentiam inseguros para os seus habitantes e qualificados "perigoso" pela imprensa .In this article I search the transformations in urban space and the uses of the place by popular sectors and their organizations in the Greater Mendoza. Housing policies and changes in the housing market have caused the suburbanization of the middle and popular classes and hierarchy of the territories during the last thirty years. In this work we study the case of Barrio La Gloria is located in the southeastern city of Godoy Cruz, an area characterized by the

  20. Estrés nutricional, hipoplasia y explotación de recursos en el centro sur de Mendoza (Argentina Nutritional stress, enamel hypoplasia, and resource exploitation in south-central Mendoza

    Directory of Open Access Journals (Sweden)

    Paula Novellino

    2007-12-01

    Full Text Available Recientemente, se ha propuesto la existencia de un proceso de intensificación en la explotación de recursos para el alto valle del río Atuel durante los últimos 2000 años (Neme et al. 2005. Si bien se han registrado cambios similares en el resto del sur de Mendoza, han surgido algunos cuestionamientos sobre el reflejo arqueológico del mismo (Borrero 2002. Hasta el momento, la discusión de este problema había sido abordada desde el registro arqueofaunístico y desde los patrones de asentamiento (Neme 2002a, 2002b. En este trabajo, se presenta el estudio de las líneas de hipoplasia dental en los restos humanos de la región, como una línea de corroboración independiente para evaluar la existencia de estrés nutricional asociado a las etapas iniciales de un proceso de intensificación. Se presentan los resultados del análisis de 1505 piezas dentales permanentes en 128 individuos del centro sur de Mendoza, comparándose con estudios similares previos en la misma región y regiones vecinas. Se discute la tendencia cronológica de las hipoplasias registradas en el contexto de la intensificación propuesta. Los resultados no son concordantes con el estrés nutricional esperado y por ello se discuten explicaciones alternativas y problemas que podrían estar produciendo este patrón distinto al esperado.The existence of an intensification process in the exploitation of resources in the upper valley of the Atuel River during the last 2000 years has recently been proposed (Neme et al. 2005. Although similar changes have been registered in the rest of southern Mendoza, doubts about the archaeological record reflective of this process have arisen (Borrero 2002. Until now discussion of this problem had been approached from the archaeofaunal record and settlement patterns (Neme 2002a, 2002b. In this paper, the study of dental enamel hypoplasia in human remains of the region as an independent test to evaluate the existence of nutritional stress

  1. Caracterización de la zona de alteración Central II, Bloque San Rafael, provincia de Mendoza Characteristics of Central II alteration zone, San Rafael Massif, province of Mendoza

    OpenAIRE

    M.F. Gargiulo; N. Rubinstein; F. Carpio; J. Salvarredi

    2007-01-01

    Se presenta el estudio petrográfico de las muestras de superficie correspondientes a la zona de alteración Central II, localizada en el Bloque San Rafael, provincia de Mendoza (34°54'56" S; 68°37'02" O). La misma está relacionada a la intrusión de un cuerpo hipabisal de composición riolítica alojado en una sucesión de rocas volcánicas y volcaniclásticas de la sección superior del Grupo Choiyoi. La zona de alteración está representada por sericitización generalizada a la que se sobreimponen br...

  2. The viticulture labor in Mendoza (Argentina during the capitalist modernization, 1880-1914 El mundo del trabajo vitivinícola en Mendoza (Argentina durante la modernización capitalista, 1880-1914

    Directory of Open Access Journals (Sweden)

    Rodolfo Richard-Jorba

    2009-01-01

    Full Text Available This paper outlines the development process of the capitalist viticulture in Mendoza. Using different primary and secondary sources, this study determines the composition of the viticulture labor and its quantitative and qualitative evolution. The introduction of up to date technology forced the training of manual labor with visible improvements in the workers' pay checks. This market became more complex through time showing multiple hierarchies in every rank of the work force, from peasants to wine makers. Several workers ascended the social ladder becoming managers due to diverse strategies traced through our various sources. Finally the workers' labor conditions indicate the vulnerability in which they were involved and their helplessness due to the lack of unions that could represent themEste artículo traza un breve panorama del proceso de desarrollo de la vitivinicultura capitalista en Mendoza y luego, utilizando diversas fuentes primarias y secundarias, determina la composición del mercado de trabajo vitivinícola y su evolución cuantitativa y cualitativa. La introducción de equipamiento técnico de avanzada obligó a la capacitación de la mano de obra con mejoras en los ingresos de los asalariados. Este mercado se complejizó con el tiempo y aparecieron múltiples jerarquías, desde el peón al enólogo o director técnico de las bodegas, pasando por los contratistas de viñas o los capataces. Muchos trabajadores ascendieron socialmente y se convirtieron en empresarios, en itinerarios que respondieron a diversas estrategias rastreables en las fuentes. Finalmente, las condiciones laborales que tuvieron los trabajadores muestran la precariedad en la que se desenvolvían y la indefensión en la que estaban inmersos por la ausencia de colectivos gremiales que asumieran la representación del trabajo frente al capital

  3. Risk, regulation and biotechnology: the case of GM crops.

    Science.gov (United States)

    Smyth, Stuart J; Phillips, Peter W B

    2014-07-01

    The global regulation of products of biotechnology is increasingly divided. Regulatory decisions for genetically modified (GM) crops in North America are predictable and efficient, with numerous countries in Latin and South America, Australia and Asia following this lead. While it might have been possible to argue that Europe's regulations were at one time based on real concerns about minimizing risks and ensuring health and safety, it is increasingly apparent that the entire European Union (EU) regulatory system for GM crops and foods is now driven by political agendas. Countries within the EU are at odds with each other as some have commercial production of GM crops, while others refuse to even develop regulations that could provide for the commercial release of GM crops. This divide in regulatory decision-making is affecting international grain trade, creating challenges for feeding an increasing global population. PMID:25437235

  4. Ecological Compatibility of GM Crops and Biological Control

    Science.gov (United States)

    Insect-resistant and herbicide-tolerant genetically modified (GM) crops pervade many modern cropping systems, and present challenges and opportunities for developing biologically-based pest management programs. Interactions between biological control agents (insect predators, parasitoids, and pathog...

  5. Risk, regulation and biotechnology: the case of GM crops.

    Science.gov (United States)

    Smyth, Stuart J; Phillips, Peter W B

    2014-07-01

    The global regulation of products of biotechnology is increasingly divided. Regulatory decisions for genetically modified (GM) crops in North America are predictable and efficient, with numerous countries in Latin and South America, Australia and Asia following this lead. While it might have been possible to argue that Europe's regulations were at one time based on real concerns about minimizing risks and ensuring health and safety, it is increasingly apparent that the entire European Union (EU) regulatory system for GM crops and foods is now driven by political agendas. Countries within the EU are at odds with each other as some have commercial production of GM crops, while others refuse to even develop regulations that could provide for the commercial release of GM crops. This divide in regulatory decision-making is affecting international grain trade, creating challenges for feeding an increasing global population.

  6. Applying a weed risk assessment approach to GM crops.

    Science.gov (United States)

    Keese, Paul K; Robold, Andrea V; Myers, Ruth C; Weisman, Sarah; Smith, Joe

    2014-12-01

    Current approaches to environmental risk assessment of genetically modified (GM) plants are modelled on chemical risk assessment methods, which have a strong focus on toxicity. There are additional types of harms posed by plants that have been extensively studied by weed scientists and incorporated into weed risk assessment methods. Weed risk assessment uses robust, validated methods that are widely applied to regulatory decision-making about potentially problematic plants. They are designed to encompass a broad variety of plant forms and traits in different environments, and can provide reliable conclusions even with limited data. The knowledge and experience that underpin weed risk assessment can be harnessed for environmental risk assessment of GM plants. A case study illustrates the application of the Australian post-border weed risk assessment approach to a representative GM plant. This approach is a valuable tool to identify potential risks from GM plants.

  7. Ganglioside GM3 modulates conformation of reconstituted Ca2+ -ATPase

    Institute of Scientific and Technical Information of China (English)

    王丽华; 杨小毅; 屠亚平; 催肇春; 杨福愉

    1997-01-01

    Using steady-state fluorescence and nanosecond time-resolved fluorescence techniques, the Ca 2+-ATPase conformational changes induced by ganglioside GM3 were studied with different quenchers. The results showed that GM3 could significantly increase the lifetime of intrinsic fluorescence of Ca2 + -ATPase reconstituted into proteoliposomes, and could also weaken the intrinsic fluorescence quenching by KI or hypocrellin B, HB. Further-more, by using quenching kinetic analysis of the time-resolved fluorescence, in the presence of GM3, the quenching constant (Ksv) and quenching efficiency were significantly lowered. The obtained results suggest that the oligosaccha-ride chain and the ceramide moieties of the GM3 molecule could interact with its counterparts of the Ca2+ -ATPase re-spectively, thus change the conformation of the hydrophobic domain of the enzyme, making the tryptophan residues in different regions shift towards the hydrophilic-hydrophobic interface, and hence shorten the distance between the hy

  8. Desarrollo poblacional de Diaspidiotus perniciosus (Hemiptera: Diaspididae en cultivos de manzano de San Carlos, Mendoza, Argentina Population development of Diaspidiotus perniciosus (Hemiptera: Diaspididae in apple orchards in San Carlos, Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Guillermo P. Lopez Garcia

    2011-12-01

    Full Text Available Se estudió la bionomía de Diaspidiotus perniciosus Comstock ("escama de San José", en manzanos de la variedad "Red delicious" de San Carlos, Mendoza, Argentina, durante los ciclos productivos 2007-2008 y 2008-2009. Se determinó el número de generaciones anuales y se estudiaron las fluctuaciones poblacionales asociadas a la integral térmica para la especie en esta región. D. perniciosus presenta dos generaciones superpuestas al ciclo del cultivo, mientras que las ninfas (N1 y N2 de la tercera generación se desarrollan solamente hasta el final de la temporada estival y pasan al estado de quiescencia, en el que permanecen durante el invierno. El desarrollo de D. perniciosus en esta zona coincide con el de esta especie en la zona frutícola del centro de Chile en cuanto al número de generaciones y al periodo de quiescencia invernal. La población quiescente en Chile está integrada predominantemente por ninfas del primer estadio (N1, mientras que en San Carlos, Mendoza, la población quiescente está integrada principalmente por ninfas del segundo estadio (N2. La similitudes entre ambas poblaciones se deben, probablemente, a las coincidencias en latitud, clima y especie hospedera. El impacto económico de D. perniciosus en la zona de estudio tiene mayor relevancia durante los meses de diciembre y enero, cuando se observa una alta incidencia de daños en los frutos y las hojas; este es el momento decisivo para implementar medidas de control fitosanitario. Estas deberán aplicarse en función de los máximos poblacionales de N1 que se producen con 600-650 Grados-Día (ºD en diciembre y con 1.170-1.270ºD en enero. En las temporadas en las que la densidad poblacional de la plaga es especialmente alta, podrían incorporarse medidas adicionales de control con 1.800-2.000ºD durante el mes de abril. Los resultados de estos estudios representan una herramienta predictiva, que permitirá elaborar estrategias para el control de poblaciones de D

  9. Public Acceptance of Plant Biotechnology and GM Crops

    OpenAIRE

    Lucht, Jan M.

    2015-01-01

    A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the divergent paths—also affecting the development of virus resistant transgenic crops—of political and regulatory frameworks for GM crops and food in different parts of the world. T...

  10. Italian Consumer Acceptance of Nutritionally Enhanced GM Food

    OpenAIRE

    Canavari, Maurizio; Tisselli, Farid; Nayga, Rodolfo M.; Scarpa, Riccardo

    2009-01-01

    The aim of this article is to evaluate Italian consumers’ acceptance and willingness to purchase GM foods based on the type of benefit (input vs output trait) and product (plant based vs animal based). Two surveys were administered in two consecutive years (2004 and 2005) and the data used to test for possible changes in consumer acceptance. The results of a multinomial logit analysis suggest that on average consumer acceptance for plant-based GM food was higher in 2005. This study confirmed ...

  11. GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion

    OpenAIRE

    D’Cruz, Osmond J.; Yiv, Seang H.; Uckun, Fatih M.

    2001-01-01

    In a systematic effort to develop a dual-function intravaginal spermicide as well as a drug delivery vehicle against sexually transmitted pathogens, a submicron particle size (30–80 nm), lipophilic and spermicidal gel-microemulsion (viz GM-144) containing the pharmaceutical excipients propylene glycol, Captex 300, Cremophor EL, Phospholipon 90G, Rhodigel, Pluronic F-68, and sodium benzoate was formulated. GM-144 completely immobilized sperm in human or rabbit semen in less than 30 seconds. Th...

  12. GM Food Crop Technology: Implications For Sub-Saharan Africa

    OpenAIRE

    Anderson, Kym; Jackson, Lee Ann

    2004-01-01

    The first generation of genetically modified (GM) crop varieties sought to increase farmer profitability through cost reductions or higher yields. The next generation of GM food research is focusing also on breeding for attributes of interest to consumers, beginning with ‘golden rice’, which has been genetically engineered to contain a higher level of vitamin A and thereby boost the health of unskilled labourers in developing countries. This Paper analyses empirically the potential economic e...

  13. Interactions between trade policies and GM food regulations

    OpenAIRE

    Kym Anderson

    2005-01-01

    Agricultural biotechnologies, and especially transgenic crops, have the potential to offer higher incomes to biotech firms and farmers, and lower-priced and better quality food for consumers. However, the welfare effects of adoption of genetically modified (GM) food and feed crop varieties are being affected not only by some countriesÂ’ strict regulations governing GM food production and consumption, but also by their choice of food trade policy instruments. Specifically, notwithstanding the ...

  14. Recasting “Substantial Equivalence”: Transatlantic Governance of GM Food

    OpenAIRE

    Levidow, Les; Murphy, Joseph; Carr, Susan

    2007-01-01

    When an intense public controversy erupted around agricultural biotechnology in the late 1990s, critics found more opportunities to challenge risk-assessment criteria and test methods for GM products. In relation to GM food, they criticised the concept of “substantial equivalence”, which EU and US regulators had adopted as the basis for a harmonised “science-based” approach to risk assessment. Scientific uncertainty was framed in different ways by competing policy agendas. “Substantial equiv...

  15. Delivery of GM-CSF to Protect against Influenza Pneumonia.

    Directory of Open Access Journals (Sweden)

    Renuka Subramaniam

    Full Text Available Since adaptive immunity is thought to be central to immunity against influenza A virus (IAV pneumonias, preventive strategies have focused primarily on vaccines. However, vaccine efficacy has been variable, in part because of antigenic shift and drift in circulating influenza viruses. Recent studies have highlighted the importance of innate immunity in protecting against influenza.Granulocyte-macrophage colony stimulating factor (GM-CSF contributes to maturation of mononuclear phagocytes, enhancing their capacity for phagocytosis and cytokine production.Overexpression of granulocyte macrophage-colony stimulating factor (GM-CSF in the lung of transgenic mice provides remarkable protection against IAV, which depends on alveolar macrophages (AM. In this study, we report that pulmonary delivery of GM-CSF to wild type young and aged mice abrogated mortality from IAV.We also demonstrate that protection is species specific and human GM-CSF do not protect the mice nor stimulates mouse immunity. We also show that IAV-induced lung injury is the culprit for side-effects of GM-CSF in treating mice after IAV infection, and introduce a novel strategy to deliver the GM-CSF to and retain it in the alveolar space even after IAV infection.

  16. Carretas y transporte terrestre bioceánico: la ruta Buenos Aires-Mendoza en el siglo XVIII

    Directory of Open Access Journals (Sweden)

    Lacoste, Pablo

    2005-01-01

    Full Text Available A carreta foi o principal meio de transporte terrestre na América colonial entre os séculos XVI e XIX. Uma das rotas mais utilizadas foi Buenos Aires-Mendoza, estabelecendo uma ligação entre os mercados do Atlântico e do Pacífico. Este artigo examina essas rotas, ao final do século XVIII, com base no processamento das viagens de 16. 000 carretas. O tema será aprofundado em um segundo trabalho intitulado "Los troperos y los orígenes de la burguesía en el Cono Sur de América colonial" (previsto para o próximo número de Estudos Ibero-Americanos

  17. El tropero y el origen de la burguesía en el Cono Sur (Mendoza, siglo XVIII

    Directory of Open Access Journals (Sweden)

    Lacoste, Pablo

    2005-01-01

    Full Text Available Este artigo aprofunda a análise sobre a carreta e o tropeiro, para definir em que medida contribuíram para o processo de construção de uma cultura empresarial na América Colonial, levando ao surgimento de uma burguesia. Atenta-se, em especial, para temas como mobilidade social, riscos empresariais, fomento do crédito em confiança ou por hipoteca de carretas, circulação de idéias e configuração de um ethos capitalista. Este trabalho constitui a continuação e a conclusão de um anterior intitulado "Carretas y transporte terrestre bioceánico: la ruta Buenos Aires-Mendoza en el siglo XVIII" (Estudos Ibero-Americanos, vol. XXXI, nº 1, 2005

  18. Caracterización de la zona de alteración Central II, Bloque San Rafael, provincia de Mendoza

    OpenAIRE

    M.F. Gargiulo; N. Rubinstein; F. Carpio; J. Salvarredi

    2007-01-01

    Se presenta el estudio petrográfico de las muestras de superficie correspondientes a la zona de alteración Central II, localizada en el Bloque San Rafael, provincia de Mendoza (34°54'56" S; 68°37'02" O). La misma está relacionada a la intrusión de un cuerpo hipabisal de composición riolítica alojado en una sucesión de rocas volcánicas y volcaniclásticas de la sección superior del Grupo Choiyoi. La zona de alteración está representada por sericitización generalizada a la que se sobreimponen br...

  19. Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.

    Science.gov (United States)

    Margheri, Francesca; Papucci, Laura; Schiavone, Nicola; D'Agostino, Riccardo; Trigari, Silvana; Serratì, Simona; Laurenzana, Anna; Biagioni, Alessio; Luciani, Cristina; Chillà, Anastasia; Andreucci, Elena; Del Rosso, Tommaso; Margheri, Giancarlo; Del Rosso, Mario; Fibbi, Gabriella

    2015-01-01

    Gangliosides and the urokinase plasminogen activator receptor (uPAR) tipically partition in specialized membrane microdomains called lipid-rafts. uPAR becomes functionally important in fostering angiogenesis in endothelial progenitor cells (EPCs) upon recruitment in caveolar-lipid rafts. Moreover, cell membrane enrichment with exogenous GM1 ganglioside is pro-angiogenic and opposite to the activity of GM3 ganglioside. On these basis, we first checked the interaction of uPAR with membrane models enriched with GM1 or GM3, relying on the adoption of solid-supported mobile bilayer lipid membranes with raft-like composition formed onto solid hydrophilic surfaces, and evaluated by surface plasmon resonance (SPR) the extent of uPAR recruitment. We estimated the apparent dissociation constants of uPAR-GM1/GM3 complexes. These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts. We have observed that addition of GM1 to EPCs culture medium promotes matrigel invasion and capillary morphogenesis, as opposed to the anti-angiogenesis activity of GM3. Moreover, GM1 also stimulates MAPKinases signalling pathways, typically associated with an angiogenesis program. Caveolar-raft isolation and Western blotting of uPAR showed that GM1 promotes caveolar-raft partitioning of uPAR, as opposed to control and GM3-challenged EPCs. By confocal microscopy, we have shown that in EPCs uPAR is present on the surface in at least three compartments, respectively, associated to GM1, GM3 and caveolar rafts. Following GM1 exogenous addition, the GM3 compartment is depleted of uPAR which is recruited within caveolar rafts thereby triggering angiogenesis.

  20. Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.

    Science.gov (United States)

    Margheri, Francesca; Papucci, Laura; Schiavone, Nicola; D'Agostino, Riccardo; Trigari, Silvana; Serratì, Simona; Laurenzana, Anna; Biagioni, Alessio; Luciani, Cristina; Chillà, Anastasia; Andreucci, Elena; Del Rosso, Tommaso; Margheri, Giancarlo; Del Rosso, Mario; Fibbi, Gabriella

    2015-01-01

    Gangliosides and the urokinase plasminogen activator receptor (uPAR) tipically partition in specialized membrane microdomains called lipid-rafts. uPAR becomes functionally important in fostering angiogenesis in endothelial progenitor cells (EPCs) upon recruitment in caveolar-lipid rafts. Moreover, cell membrane enrichment with exogenous GM1 ganglioside is pro-angiogenic and opposite to the activity of GM3 ganglioside. On these basis, we first checked the interaction of uPAR with membrane models enriched with GM1 or GM3, relying on the adoption of solid-supported mobile bilayer lipid membranes with raft-like composition formed onto solid hydrophilic surfaces, and evaluated by surface plasmon resonance (SPR) the extent of uPAR recruitment. We estimated the apparent dissociation constants of uPAR-GM1/GM3 complexes. These preliminary observations, indicating that uPAR binds preferentially to GM1-enriched biomimetic membranes, were validated by identifying a pro-angiogenic activity of GM1-enriched EPCs, based on GM1-dependent uPAR recruitment in caveolar rafts. We have observed that addition of GM1 to EPCs culture medium promotes matrigel invasion and capillary morphogenesis, as opposed to the anti-angiogenesis activity of GM3. Moreover, GM1 also stimulates MAPKinases signalling pathways, typically associated with an angiogenesis program. Caveolar-raft isolation and Western blotting of uPAR showed that GM1 promotes caveolar-raft partitioning of uPAR, as opposed to control and GM3-challenged EPCs. By confocal microscopy, we have shown that in EPCs uPAR is present on the surface in at least three compartments, respectively, associated to GM1, GM3 and caveolar rafts. Following GM1 exogenous addition, the GM3 compartment is depleted of uPAR which is recruited within caveolar rafts thereby triggering angiogenesis. PMID:25313007

  1. High-brightness electron injectors

    International Nuclear Information System (INIS)

    Free-electron laser (FEL) oscillators and synchrotron light sources require pulse trains of high peak brightness and, in some applications, high-average power. Recent developments in the technology of photoemissive and thermionic electron sources in rf cavities for electron-linac injector applications offer promising advances over conventional electron injectors. Reduced emittance growth in high peak-current electron injectors may be achieved by using high field strengths and by linearizing the radial component of the cavity electric field at the expense of lower shunt impedance

  2. High brightness beams and applications

    International Nuclear Information System (INIS)

    This paper describes the present research on attaining intense bright electron beams. Thermionic systems are briefly covered. Recent and past results from the photoinjector programs are given. The performance advantages and difficulties presently faced by researchers using photoinjectors is discussed. The progress that has been made in photocathode materials, both in lifetime and quantum efficiency, is covered. Finally, a discussion of emittance measurements of photoinjector systems and how the measurement is complicated by the non-thermal nature of the electron beam is presented

  3. The Bright New Financial System

    Directory of Open Access Journals (Sweden)

    Associate Professor Adela Coman

    2009-05-01

    Full Text Available By the end of 2008, Mr. Paul Volcker gave financiers a devastating critique. “For all its talented participants, for all its rich rewards” he said, the “bright new financial system” has “failed the test of the marketplace”.In light of the events of recent weeks, it is hard to disagree. A financial system that ends up with the government taking over some of its biggest institutions in serial weekend rescues and which requires the promise of 700 billion dollars in public money to stave off catastrophe is not a trustworthy system. The disappearance of all five big American investment banks – either by bankruptcy or rebirth as commercial banks – is powerful evidence that Wall Street failed “the test of the marketplace”. Something went wrong.But what exactly and why? A more serious analysis needs to distinguish between three separate questions: what is Mr. Volcker’s “bright new financial system”? Second, how far was today’s mess created by instabilities that are inseparable from modern finance and how far was it fuelled by other errors and distortions? Third, to the extent that modern finance does bear the blame, what is the balance between its costs and its benefits and how can it be improved?

  4. China, India Lead Asia Race on GM Crops

    Institute of Scientific and Technical Information of China (English)

    Dolly; Aglay; 谢丽英

    2000-01-01

    本文标题出现了GM Crops,用鼠标轻点其中的GM,竟然出现了“冈比亚”的释义!再查陆谷孙教授主编的《英汉大词典补编》,也没有见其踪影。其实,在文章的首段就可以找到GM Crops之释义:GM Crops=geneticallymodified crops。我想在不久的将来,英汉词典就会收入GM。当然,科技的发展永远领先于词典收入的新词。GM Crops如何译呢?可否译作“基因更改的农作物”?biotechnology(生物工艺学)和biosciences(生物科学)两个新词,前者已经收入了《英汉大词典补编》,后者尚有待收入。 本文向读者透露,当今世界并非一片为GM Crops大声叫好(a strong yes tobiotechnology)的声音: …grave concerns in Europe over the long-term environmental and healtheffects of genetically modified food. 在争论日趋激烈之时,本文亮出的观点是: …worries that GM crops may harm the environment or may not be safe tohealth have no scientific basis.

  5. Los territorios de la violencia en la novela policial y la narcoliteratura latinoamericana: Mario Mendoza, Peter Elmore y Alejandro Páez

    Directory of Open Access Journals (Sweden)

    Danilo Santos López

    2015-12-01

    Full Text Available El artículo expone la problemática de la violencia en las sociedades latinoamericanas a través de su representación en una serie de novelas publicadas a partir de los años noventa. Para ello se seleccionó las novelas policiales Enigma de los cuerpos (1995 de Peter Elmore, Satanás (2002 de Mario Mendoza y las narconovelas Corazón de Kalashnikov (2009, El reino de las moscas (2012 y Música para perros (2013 de Alejandro Páez Varela. Ellos son textos que recogen la situación de los personajes-víctimas de la novela criminalizada a través de la mirada narrativa sobre territorios muy delimitados como la Lima de Elmore, la Bogotá de Mendoza y Ciudad Juárez de Páez Varela.

  6. FUNEBRIA CATÓLICA Y ESTIMACIONES DEL SEXO Y DE LA EDAD EN ENTIERROS DE UNA CIUDAD AMERICANA COLONIAL (MENDOZA, ARGENTINA, SIGLOS XVII-XIX

    Directory of Open Access Journals (Sweden)

    Horacio Chiavazza

    2015-07-01

    Full Text Available Knowledge of the handling death in the life of a colonial city realizes the social and biological processes of its inhabitants. In the city of Mendoza, founded in 1561, an installation process of temples that got to add a total of eight major in the village over 300 years was recorded. The buildings grew under the colonial consolidation, reaching become iconic for its architectural styles and investment in building materials. Indeed, the buildings were growing and excelling in the urban landscape. We understand that this gave a sense of the city and the citizens from the ritual was practiced there, including one very important: the funeral. We present the results of the excavations in temples built by Jesuits, Dominicans, Mercedarios, Franciscans and Augustinians in the city of Mendoza. Attention in the history of religious facilities is placed and people buried in them between the seventeenth and nineteenth centuries, as analyzed by sex and age categories characterized.

  7. Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment

    OpenAIRE

    Liu, Yujing; Hoffmann, Alexander; Grinberg, Alexander; Westphal, Heiner; McDonald, Michael P.; Miller, Katherine M.; Crawley, Jacqueline N; Sandhoff, Konrad; Suzuki, Kinuko; Proia, Richard L.

    1997-01-01

    The GM2 activator deficiency (also known as the AB variant), Tay–Sachs disease, and Sandhoff disease are the major forms of the GM2 gangliosidoses, disorders caused by defective degradation of GM2 ganglioside. Tay–Sachs and Sandhoff diseases are caused by mutations in the genes (HEXA and HEXB) encoding the subunits of β-hexosaminidase A. The GM2 activator deficiency is caused by mutations in the GM2A gene encoding the GM2 activator protein. For degradation of GM2 ganglioside by β-hexosamindas...

  8. Lineamientos para la definición de un modo de crecimiento urbano sostenible en tierras secas: el caso de la provincia de Mendoza, Argentina

    OpenAIRE

    Sammartino, Mariana Silvina

    2015-01-01

    Actualmente, el fenómeno de globalización está generando procesos territoriales que modifican sustancialmente los sistemas urbanos, con su consiguiente impacto sobre la organización territorial. En Mendoza, los procesos territoriales han generado un modelo territorial de concentración difusa desequilibrada, reflejo de una región subdesarrollada con una estructura espacial muy jerarquizada y un predominio de urbanización difusa, fuertemente concentrada en las escasas tierras secas irrigadas...

  9. Analysis of the potential production and the development of bioenergy in the province of Mendoza - Bio-fuels and biomass - Using geographic information systems

    International Nuclear Information System (INIS)

    In this work, the partial results of the potential production of energy, starting from the biomass and the development of the crops, directed to the production of bio-fuels (Colza and Topinamur) in the North irrigation oasis of Mendoza, Argentina within the National Program of Bio-energy developed by INTA is presented. For the evaluation of the bio-energetic potential, derived from the biomass, the WISDOM methodology developed by FAO and implemented by INTA in Argentina was applied with the collaboration of national and provincial governmental entities that contribute local information The study of the potential production and the development of the bio-energetic crops have been carried out with the advising and participation of the experts of INTA of the studied crops. The province of Mendoza has semi-deserted agro-climatic characteristics. The type of soil and type of weather allows the production of great quality fruits and vegetables in the irrigated areas. The four great currents of water conform three oasis; Northeast, Center and South, which occupy the 3.67% of the surface of Mendoza. Today, Mendoza has 267,889 irrigated hectares, but the surface that was farmed by irrigation was near to the 400,000 ha. The climate contingencies, froze and hailstorm precipitations, plus the price instability cause great losses in the productive sector, taking it to the forlornness of the exploitations. The crop setting of these forlornness lands with crops directed to the production of bio-fuels and the utilization of the biomass coming from the agriculture activities and the agro industry (pruning of fruit trees, refuses of olive and vine, remnants of the peach industry, etc.) could assist the access to the energy in the rural areas, stimulating the economical improvement and the development in these communities. (author)

  10. Analysis of the potential production and the development of bioenergy in the province of Mendoza - Bio-fuels and biomass - Using geographic information systems

    Energy Technology Data Exchange (ETDEWEB)

    Flores Marco, Noelia; Hilbert, Jorge Antonio [Instituto de Ingenieria Rural, INTA Las Cabanas y Los Reseros s/n, CP: 1712 Castelar, Buenos Aires (Argentina); Silva Colomer, Jorge [INTA EEA Junin Mendoza, Carril Isidoro Busquets s/n CP: 5572 (Argentina); Anschau, Renee Alicia; Carballo, Stella [Instituto de Clima y Agua, INTA. Las Cabanas y Los Reseros s/n, CP:1712 Castelar, Buenos Aires (Argentina)

    2010-06-15

    In this work, the partial results of the potential production of energy, starting from the biomass and the development of the crops, directed to the production of bio-fuels (Colza and Topinamur) in the North irrigation oasis of Mendoza, Argentina within the National Program of Bio-energy developed by INTA is presented. For the evaluation of the bio-energetic potential, derived from the biomass, the WISDOM methodology developed by FAO and implemented by INTA in Argentina was applied with the collaboration of national and provincial governmental entities that contribute local information The study of the potential production and the development of the bio-energetic crops have been carried out with the advising and participation of the experts of INTA of the studied crops. The province of Mendoza has semi-deserted agro-climatic characteristics. The type of soil and type of weather allows the production of great quality fruits and vegetables in the irrigated areas. The four great currents of water conform three oasis; Northeast, Center and South, which occupy the 3.67% of the surface of Mendoza. Today, Mendoza has 267,889 irrigated hectares, but the surface that was farmed by irrigation was near to the 400,000 ha. The climate contingencies, froze and hailstorm precipitations, plus the price instability cause great losses in the productive sector, taking it to the forlornness of the exploitations. The crop setting of these forlornness lands with crops directed to the production of bio-fuels and the utilization of the biomass coming from the agriculture activities and the agro industry (pruning of fruit trees, refuses of olive and vine, remnants of the peach industry, etc.) could assist the access to the energy in the rural areas, stimulating the economical improvement and the development in these communities. (author)

  11. How Bright Can Supernovae Get?

    Science.gov (United States)

    Kohler, Susanna

    2016-04-01

    Supernovae enormous explosions associated with the end of a stars life come in a variety of types with different origins. A new study has examined how the brightest supernovae in the Universe are produced, and what limits might be set on their brightness.Ultra-Luminous ObservationsRecent observations have revealed many ultra-luminous supernovae, which haveenergies that challenge our abilities to explain them usingcurrent supernova models. An especially extreme example is the 2015 discovery of the supernova ASASSN-15lh, which shone with a peak luminosity of ~2*1045 erg/s, nearly a trillion times brighter than the Sun. ASASSN-15lh radiated a whopping ~2*1052 erg in the first four months after its detection.How could a supernova that bright be produced? To explore the answer to that question, Tuguldur Sukhbold and Stan Woosley at University of California, Santa Cruz, have examined the different sources that could produce supernovae and calculated upper limits on the potential luminosities ofeach of these supernova varieties.Explosive ModelsSukhbold and Woosley explore multiple different models for core-collapse supernova explosions, including:Prompt explosionA stars core collapses and immediately explodes.Pair instabilityElectron/positron pair production at a massive stars center leads to core collapse. For high masses, radioactivity can contribute to delayed energy output.Colliding shellsPreviously expelled shells of material around a star collide after the initial explosion, providing additional energy release.MagnetarThe collapsing star forms a magnetar a rapidly rotating neutron star with an incredibly strong magnetic field at its core, which then dumps energy into the supernova ejecta, further brightening the explosion.They then apply these models to different types of stars.Setting the LimitThe authors show that the light curve of ASASSN-15lh (plotted in orange) can be described by a model (black curve) in which a magnetar with an initial spin period of 0.7 ms

  12. [Bright light therapy for elderly].

    Science.gov (United States)

    Okawa, Masako

    2015-06-01

    Bright light therapy (BLT) holds considerable promise for sleep problems in the elderly. BLT for community-dwelling patients with Alzheimer's disease showed significant improvement in sleep parameters. In the institutional setting, BLT was effective in reducing daytime nap duration. Morning BLT was found to advance the peak circadian rhythm and increase activity level in daytime and melatonin level at night. Light therapy could be used in combination with other nonpharmacological methods such as social activities, outside walking, physical exercises, which showed greater effects than independent BLT on sleep and cognitive function. BLT treatment strategy was proposed in the present paper. We should pay more attentions to BLT in community setting for mental and physical well-being. PMID:26065132

  13. Constantly evolving safety assessment protocols for GM foods.

    Science.gov (United States)

    Sesikeran, B; Vasanthi, Siruguri

    2008-01-01

    he introduction of GM foods has led to the evolution of a food safety assessment paradigm that establishes safety of the GM food relative to its conventional counterpart. The GM foods currently approved and marketed in several countries have undergone extensive safety testing under a structured safety assessment framework evolved by international organizations like FAO, WHO, Codex and OECD. The major elements of safety assessment include molecular characterization of inserted genes and stability of the trait, toxicity and allergenicity potential of the expressed substances, compositional analysis, potential for gene transfer to gut microflora and unintentional effects of the genetic modification. As more number and type of food crops are being brought under the genetic modification regime, the adequacy of existing safety assessment protocols for establishing safety of these foods has been questioned. Such crops comprise GM crops with higher agronomic vigour, nutritional or health benefit/ by modification of plant metabolic pathways and those expressing bioactive substances and pharmaceuticals. The safety assessment challenges of these foods are the potential of the methods to detect unintentional effects with higher sensitivity and rigor. Development of databases on food compositions, toxicants and allergens is currently seen as an important aid to development of safety protocols. With the changing global trends in genetic modification technology future challenge would be to develop GM crops with minimum amount of inserted foreign DNA so as to reduce the burden of complex safety assessments while ensuring safety and utility of the technology.

  14. GM organisms threaten organic systems: towards sustainability, coexistence and organic seed

    OpenAIRE

    Boelt, B.; Deleuran, L.C.; Phelps, B.

    2005-01-01

    Until now commercial genetically modified (GM) crops – soy, corn, canola and cotton - and their products have not been successfully segregated from organic or conventional non-GM production systems. Where GM crops are grown, GM contamination may be inevitable. However, physical and legal control measures imposed before the introduction of GM crops may help protect organic standards, supply chain integrity, certification and client confidence, but this is not yet fully tested. IFOAM’s approach...

  15. Consumers’ WTA for GM rice cookie: an experiment study in China

    OpenAIRE

    Liu, Pengcheng

    2009-01-01

    This paper uses experimental auction method to study the WTA for GM rice cookies of Chinese consumers. The bid data are collected from 353 randomly recruited undergraduate students participated in Wuhan, China, during the spring and early summer of 2008.The experiment auction suggest most participant hold a positive WTA for GM rice cookie, which suggest that consumers regard GM rice an inferior substitutes for non-GM rice. Information favorable of GM rice will decrease the WTA, while negative...

  16. Rincón del Atuel-1 (San Rafael, Mendoza: evidencias arqueológicas e implicancias regionales Rincon Del Atuel-1 (San Rafael, Mendoza: Archaeological Evidence And Regional Implications

    Directory of Open Access Journals (Sweden)

    Adolfo Gil

    2008-12-01

    Full Text Available El sitio Rincón del Atuel 1 (RA-1 fue uno de los primeros estudiado sistemáticamente en los inicios de la arqueología del sur de Mendoza y del que se conocía solo información proveniente de la superficie. Sobre la base de excavaciones recientes se detallan las evidencias arqueológicas del sitio. Asimismo se incorporan datos disponibles de colecciones previas. Sus ocupaciones se registran en los últimos 1500-1700 años AP y mostrarían dos momentos distintos; el más tardío desde hace unos 1000-1200 años AP y el otro desde esa fecha a unos 1500-1700 años AP. El conjunto más tardío se asocia a un suelo y mostraría características de "sitio somero" mientras que el conjunto inferior se relacionaría depositacionalmente con la planicie de inundación del río Atuel por lo que presentaría mejor resolución temporal. El registro arqueobotánico y los valores isotópicos en muestras humanas avalan una dieta mixta de maíz con otras plantas silvestres al menos para el conjunto más antiguo. La evidencia no es concordante con lo esperable para un patrón semi-sedentario o sedentario propuesto previamente para entender las ocupaciones agrícolas del área. Este registro es significativo para comprender la estructura arqueológica en valles fluviales de zonas áridas, y discutir temas como la intensificación regional y el significado de los cultígenos.Rincón del Atuel-1 is an open air archaeological site located in the current alluvial valley of the Atuel River, Mendoza Province (Argentina. The site was studied during the first stage of archaeological research in southern Mendoza. However, only the surface archaeological record was studied and no information was published about the material in stratigraphic context. Recently, excavations were carried out in order to explore issues related to the Late Holocene human occupation. The results presented here show that the site was occupied from 1500-1700 14C years BP until recently (at least ca

  17. Quantum communication with macroscopically bright nonclassical states.

    Science.gov (United States)

    Usenko, Vladyslav C; Ruppert, Laszlo; Filip, Radim

    2015-11-30

    We analyze homodyne detection of macroscopically bright multimode nonclassical states of light and propose their application in quantum communication. We observe that the homodyne detection is sensitive to a mode-matching of the bright light to the highly intense local oscillator. Unmatched bright modes of light result in additional noise which technically limits detection of Gaussian entanglement at macroscopic level. When the mode-matching is sufficient, we show that multimode quantum key distribution with bright beams is feasible. It finally merges the quantum communication with classical optical technology of visible beams of light. PMID:26698776

  18. NMR-Metabolic Methodology in the Study of GM Foods

    Directory of Open Access Journals (Sweden)

    Irene D’Amico

    2010-01-01

    Full Text Available The 1H-NMR methodology used in the study of genetically modified (GM foods is discussed. Transgenic lettuce (Lactuca sativa cv "Luxor" over-expressing the Arabidopsis KNAT1 gene is presented as a case study. Twenty-two water-soluble metabolites (amino acids, organic acids, sugars present in leaves of conventional and GM lettuce were monitored by NMR and quantified at two developmental stages. The NMR spectra did not reveal any difference in metabolite composition between the GM lettuce and the wild type counterpart. Statistical analyses of metabolite variables highlighted metabolism variation as a function of leaf development as well as the transgene. A main effect of the transgene was in altering sugar metabolism.

  19. Categorization of field trials with GM plants in the Netherlands: applicable to field trials with GM forest trees?

    Directory of Open Access Journals (Sweden)

    Glandorf DCM

    2015-04-01

    Full Text Available In the Netherlands, criteria have been set for field trials with genetically modified (GM plants. These criteria are based on the step-by-step principle as described in European Directive 2001/18/EC. Three categories of field trials are defined. The first category concerns small-scale field trials with GM plants that are not well characterised on the molecular and phenotypic level. Confinement measures are applied in order to limit potential adverse effects to the field location. The second category consists of small-scale field experiments with GM plants that are better characterized. Confinement measures are no longer necessary since sufficient information is available to assess potential adverse effects on human health and the environment for these trials. The third category consists of large-scale field trials with fully characterised GM plants and without the need of confinement measures. For each category, a new permit is required. This system has been used for several crops, including apple and poplar trees and may also be applicable for trials with GM forest trees.

  20. GM crops and the rat digestive tract: a critical review.

    Science.gov (United States)

    Zdziarski, I M; Edwards, J W; Carman, J A; Haynes, J I

    2014-12-01

    The aim of this review is to examine the relationship between genetically modified (GM) crops and health, based on histopathological investigations of the digestive tract in rats. We reviewed published long-term feeding studies of crops containing one or more of three specific traits: herbicide tolerance via the EPSPS gene and insect resistance via cry1Ab or cry3Bb1 genes. These genes are commonly found in commercialised GM crops. Our search found 21 studies for nine (19%) out of the 47 crops approved for human and/or animal consumption. We could find no studies on the other 38 (81%) approved crops. Fourteen out of the 21 studies (67%) were general health assessments of the GM crop on rat health. Most of these studies (76%) were performed after the crop had been approved for human and/or animal consumption, with half of these being published at least nine years after approval. Our review also discovered an inconsistency in methodology and a lack of defined criteria for outcomes that would be considered toxicologically or pathologically significant. In addition, there was a lack of transparency in the methods and results, which made comparisons between the studies difficult. The evidence reviewed here demonstrates an incomplete picture regarding the toxicity (and safety) of GM products consumed by humans and animals. Therefore, each GM product should be assessed on merit, with appropriate studies performed to indicate the level of safety associated with them. Detailed guidelines should be developed which will allow for the generation of comparable and reproducible studies. This will establish a foundation for evidence-based guidelines, to better determine if GM food is safe for human and animal consumption.

  1. GM crops and the rat digestive tract: a critical review.

    Science.gov (United States)

    Zdziarski, I M; Edwards, J W; Carman, J A; Haynes, J I

    2014-12-01

    The aim of this review is to examine the relationship between genetically modified (GM) crops and health, based on histopathological investigations of the digestive tract in rats. We reviewed published long-term feeding studies of crops containing one or more of three specific traits: herbicide tolerance via the EPSPS gene and insect resistance via cry1Ab or cry3Bb1 genes. These genes are commonly found in commercialised GM crops. Our search found 21 studies for nine (19%) out of the 47 crops approved for human and/or animal consumption. We could find no studies on the other 38 (81%) approved crops. Fourteen out of the 21 studies (67%) were general health assessments of the GM crop on rat health. Most of these studies (76%) were performed after the crop had been approved for human and/or animal consumption, with half of these being published at least nine years after approval. Our review also discovered an inconsistency in methodology and a lack of defined criteria for outcomes that would be considered toxicologically or pathologically significant. In addition, there was a lack of transparency in the methods and results, which made comparisons between the studies difficult. The evidence reviewed here demonstrates an incomplete picture regarding the toxicity (and safety) of GM products consumed by humans and animals. Therefore, each GM product should be assessed on merit, with appropriate studies performed to indicate the level of safety associated with them. Detailed guidelines should be developed which will allow for the generation of comparable and reproducible studies. This will establish a foundation for evidence-based guidelines, to better determine if GM food is safe for human and animal consumption. PMID:25244705

  2. [Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].

    Science.gov (United States)

    Tsuji, Daisuke

    2013-01-01

    Tay-Sachs and Sandhoff diseases (GM2 gangliosidoses) are autosomal recessive lysosomal storage diseases caused by gene mutations in HEXA and HEXB, each encoding human lysosomal β-hexosaminidase α-subunits and β-subunits, respectively. In Tay-Sachs disease, excessive accumulation of GM2 ganglioside (GM2), mainly in the central nervous system, is caused by a deficiency of the HexA isozyme (αβ heterodimer), resulting in progressive neurologic disorders. In Sandhoff disease, combined deficiencies of HexA and HexB (ββ homodimer) cause not only the accumulation of GM2 but also of oligosaccharides carrying terminal N-acetylhexosamine residues (GlcNAc-oligosaccharides), resulting in systemic manifestations including hepatosplenomegaly as well as neurologic symptoms. Hence there is little clinically effective treatment for these GM2 gangliosidoses. Recent studies on the molecular pathogenesis in Sandhoff disease patients and disease model mice have shown the involvement of microglial activation and chemokine induction in neuroinflammation and neurodegeneration in this disease. Experimental and therapeutic approaches, including recombinant enzyme replacement, have been performed using Sandhoff disease model mice, suggesting the future application of novel techniques to treat GM2 gangliosidoses (Hex deficiencies), including Sandhoff disease as well as Tay-Sachs disease. In this study, we isolated astrocytes and microglia from the neonatal brain of Sandhoff disease model mice and demonstrated abnormalities of glial cells. Moreover, we demonstrated the therapeutic effect of an intracerebroventricular administration of novel recombinant human HexA carrying a high content of M6P residue in Sandhoff disease model mice. PMID:23370522

  3. Flujos de detritos recientes en la cordillera frontal de Mendoza: Un ejemplo de riesgo natural en la ruta 7 Recent debris flows in the Frontal Cordillera of Mendoza: an example of natural risk on the Road 7

    Directory of Open Access Journals (Sweden)

    Emmanuel Wick

    2010-06-01

    Full Text Available Se expone un estudio sobre los flujos de detritos ocurridos en enero de 2005, en el km 1.118,5 de la ruta nacional 7 en la provincia de Mendoza. La zona se ubica en la Cordillera Frontal, próxima al límite con la Precordillera. Se realizó un mapa geomorfológico detallado, sobre la base de una imagen Quickbird del año 2006. Además, se hicieron cálculos de volúmenes, velocidades y caudales, con mediciones en el campo y con ayuda de un sistema de información geográfico (SIG. El estudio de la geomorfología permitió proponer tres escenarios para el caso de un nuevo evento, a partir de los cuáles se creó un mapa de susceptibilidad a los flujos de detritos para el tramo de ruta analizado. Finalmente, se proponen medidas de protección y de mitigación ante la posibilidad de recurrencia de estos eventos en el sector.In this paper is presented a study dealing with the debris flows that reached the national road 7 in January 2005, in the km 1,118.5, Mendoza province. The area is located in the Frontal Cordillera near the limit of the Precordillera. A detailed geomorphologic map has been realized for this study using a Quickbird satellite imagery of the year 2006. Various calculations of volumes, velocities and peak discharges have been performed with the field data and using a geographic information system (GIS. The geomorphologic survey has permitted to propose three propagation scenarios in case of a new event. These allowed creating a map of debris flows susceptibility for the stretch of the road that has been studied. Finally, it has been proposed protection and mitigation measures, based on the results of the study, to protect the road from a new event.

  4. Caracterización de la zona de alteración Central II, Bloque San Rafael, provincia de Mendoza Characteristics of Central II alteration zone, San Rafael Massif, province of Mendoza

    Directory of Open Access Journals (Sweden)

    M.F. Gargiulo

    2007-09-01

    Full Text Available Se presenta el estudio petrográfico de las muestras de superficie correspondientes a la zona de alteración Central II, localizada en el Bloque San Rafael, provincia de Mendoza (34°54'56" S; 68°37'02" O. La misma está relacionada a la intrusión de un cuerpo hipabisal de composición riolítica alojado en una sucesión de rocas volcánicas y volcaniclásticas de la sección superior del Grupo Choiyoi. La zona de alteración está representada por sericitización generalizada a la que se sobreimponen brechas y venas silíceas, ocasionalmente con textura drusiforme y con bandas tapizadas por agregados diseminados de pirita y calcopirita subordinada, a las que acompaña escasa arsenopirita. Las brechas y venas silíceas conforman una faja de dirección ONO (azimut 290° - 300° e inclinación vertical, en las que se han reconocido texturas de cuarzo hidrotermal de crecimiento primario, de recristalización y de reemplazo. Entre estas texturas se destacan las crustificaciones complejas, el bandeamiento coloforme y los pseudomorfos de cuarzo según calcita en enrejado, a las que se asocia la presencia de adularia con morfologías sub-rómbica, rómbica y pseudo-acicular. Este conjunto de texturas y morfologías permite establecer que se trata de un sistema epitermal de baja sulfuración con paleozonas de ebullición ascendente.The goal of this paper is to present the petrographic study from outcrop samples of the Central II alteration zone. This area is located in the San Rafael Massif, province of Mendoza (34°54'56" S; 68°37'02" O and is related to hypoabyssal rhyolitic bodies that intrude a volcanic-volcaniclastic sequence corresponding to the upper section of Choiyoi Group. The alteration zone is represented by pervasive sericitization overprinted by silicic breccias and veins with WNW trend (Az 290° - 300° and vertical dip. Hydrothermal veins are mainly composed by quartz with primary growth, recrystalization and replacement textures with

  5. Generalized shrunken type-GM estimator and its application

    Science.gov (United States)

    Ma, C. Z.; Du, Y. L.

    2014-03-01

    The parameter estimation problem in linear model is considered when multicollinearity and outliers exist simultaneously. A class of new robust biased estimator, Generalized Shrunken Type-GM Estimation, with their calculated methods are established by combination of GM estimator and biased estimator include Ridge estimate, Principal components estimate and Liu estimate and so on. A numerical example shows that the most attractive advantage of these new estimators is that they can not only overcome the multicollinearity of coefficient matrix and outliers but also have the ability to control the influence of leverage points.

  6. Recent development status of compact 2 K GM cryocoolers

    Science.gov (United States)

    Bao, Q.; Xu, M. Y.; Tsuchiya, A.; Li, R.

    2015-12-01

    To meet the growing demand for a compact cooling solution for superconducting electronic devices, we developed a two-stage 2 K GM cryocooler and a cryostat system, which can reach 46.3 K / 2.2 K on the first and second stages under no-load conditions. Nevertheless, with several innovative technologies applied, the total length of the expander cylinder is reduced to under 70% of the smallest conventional 4 K GM cryocooler. In this paper we will present the design method, including material selection and structure design with detailed explanation, which has been confirmed by both simulation and experiment.

  7. Política habitacional comparada: Mendoza y San Luis en el marco de la descentralización

    Directory of Open Access Journals (Sweden)

    Delia Palero

    2006-01-01

    Full Text Available El artículo plantea un análisis comparado entre las políticas habitacionales desarrolladas por dos provincias argentinas: Mendoza y San Luis. La federalización de los recursos del FONAVI en el país, ocurrida en l992, puso fin a una prolongada etapa de política habitacional centralizada en Argentina. El período analizado abarca la década comprendida entre ese año y el 2002. A nivel internacional se consolida el proceso de globalización que, en el terreno de la vivienda, se tradujo en el predominio del enfoque facilitador. Los casos elegidos representan dos modelos diametralmente distintos que, sin embargo, alcanzaron resultados que podrían calificarse de exitosos en el concierto nacional. Mientras el primero se inscribe en el paradigma central-sectorial, el segundo adhiere en forma predominante al enfoque facilitador. El análisis de política comparada ha sido contextualizado en los escenarios político, social, cultural y económico que le dieron marco, sentido y viabilidad a ambos modelos, que marcaron tanto sus fortalezas como sus debilidades y que explican los resultados alcanzados. Vinculación con la formación universitaria: La Cátedra Problemática de la Vivienda se encuentra en la Facultad de Ciencias Políticas y Sociales (U.N.Cuyo e incluye en su programa unidades referidas a política habitacional en Argentina y en la provincia de Mendoza. En tal sentido, se estima que los resultados obtenidos a partir de este trabajo resultan un insumo de interés para estudiantes de trabajo social, sociología y ciencia política, en tanto permiten analizar en profundidad conceptos como centralizacióndescentralización, participación, articulación de actores, focalización, eficiencia y eficacia en la gestión de la política habitacional, entre otros, y cómo éstos se manifiestan en la práctica política concreta.

  8. Soliton fay identities: II. Bright soliton case

    International Nuclear Information System (INIS)

    We present a set of bilinear matrix identities that generalize the ones that have been used to construct the bright soliton solutions for various models. As an example of an application of these identities, we present a simple derivation of the N-bright soliton solutions for the Ablowitz–Ladik hierarchy. (paper)

  9. Spatial Brightness Perception of Trichromatic Stimuli

    Energy Technology Data Exchange (ETDEWEB)

    Royer, Michael P.; Houser, Kevin W.

    2012-11-16

    An experiment was conducted to examine the effect of tuning optical radiation on brightness perception for younger (18-25 years of age) and older (50 years of age or older) observers. Participants made forced-choice evaluations of the brightness of a full factorial of stimulus pairs selected from two groups of four metameric stimuli. The large-field stimuli were created by systematically varying either the red or the blue primary of an RGB LED mixture. The results indicate that light stimuli of equal illuminance and chromaticity do not appear equally bright to either younger or older subjects. The rank-order of brightness is not predicted by any current model of human vision or theory of brightness perception including Scotopic to Photopic or Cirtopic to Photopic ratio theory, prime color theory, correlated color temperature, V(λ)-based photometry, color quality metrics, linear brightness models, or color appearance models. Age may affect brightness perception when short-wavelength primaries are used, especially those with a peak wavelength shorter than 450 nm. The results suggest further development of metrics to predict brightness perception is warranted, and that including age as a variable in predictive models may be valuable.

  10. SURFACE PHOTOMETRY OF LOW SURFACE BRIGHTNESS GALAXIES

    NARCIS (Netherlands)

    DEBLOK, WJG; VANDERHULST, JM; BOTHUN, GD

    1995-01-01

    Low surface brightness (LSB) galaxies are galaxies dominated by an exponential disc whose central surface brightness is much fainter than the value of mu(B)(0) = 21.65 +/- 0.30 mag arcsec(-2) found by Freeman. In this paper we present broadband photometry of a sample of 21 late-type LSB galaxies. Th

  11. Brightness and darkness as perceptual dimensions

    NARCIS (Netherlands)

    Vladusich, T.; Lucassen, M.P.; Cornelissen, F.W.

    2007-01-01

    A common-sense assumption concerning visual perception states that brightness and darkness cannot coexist at a given spatial location. One corollary of this assumption is that achromatic colors, or perceived grey shades, are contained in a one-dimensional (1-D) space varying from bright to dark. The

  12. Incoherently coupled dark-bright photorefractive solitons

    Science.gov (United States)

    Chen, Zhigang; Segev, Mordechai; Coskun, Tamer H.; Christodoulides, Demetrios N.; Kivshar, Yuri S.; Afanasjev, Vsevolod V.

    1996-11-01

    We report the observation of incoherently coupled dark-bright spatial soliton pairs in a biased bulk photorefractive crystal. When such a pair is decoupled, the dark component evolves into a triplet structure, whereas the bright one decays into a self-defocusing beam.

  13. Brightness Alteration with Interweaving Contours

    Directory of Open Access Journals (Sweden)

    Sergio Roncato

    2012-12-01

    Full Text Available Chromatic induction is observed whenever the perceived colour of a target surface shifts towards the hue of a neighbouring surface. Some vivid manifestations may be seen in a white background where thin coloured lines have been drawn (assimilation or when lines of different colours are collinear (neon effect or adjacent (watercolour to each other. This study examines a particular colour induction that manifests in concomitance with an opposite effect of colour saturation (or anti-spread. The two phenomena can be observed when a repetitive pattern is drawn in which outline thin contours intercept wider contours or surfaces, colour spreading appear to fill the surface occupied by surfaces or thick lines whereas the background traversed by thin lines is seen as brighter or filled of a saturated white. These phenomena were first observed by Bozzi (1975 and Kanizsa (1979 in figural conditions that did not allow them to document their conjunction. Here we illustrate various manifestations of this twofold phenomenon and compare its effects with the known effects of brightness and colour induction. Some conjectures on the nature of these effects are discussed.

  14. Geophysical studies applied to the exploration of the Aqua de las Liebres uranium deposit, Mendoza, Argentina; Estudios geofisicos en la exploracion de yacimientos de uranio Aqua de las Liebres, mendoza, Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Pastore, Silvio Augusto; Rocco, Guillermo Felix E.; Ponti, Norberto [Instituto Sismologico F.S. Volponi (Argentina)

    1995-12-31

    The aim of this work was to apply a geophysical methodology, which let us make exploration studies of Uranium ore deposit, with good results and minimal costs. This technique will be used by the National Commission of Atomic Energy of Argentina (CNEA). This study was made at Agua de las Liebres site, Sierra Pintada-San Rafael-Mendoza, over an existing seismic path. Besides, there were three roles, digged up to the interesting level with a medium depth about 400 m. This investigation was made using the Vertical Electrical Sounding with a maximum AB = 3870 m. It could be used in the zone knowing that there were sub horizontal layered strata, with very important resistivity contrasts for its identification. The use of this methodology led us to obtain a more detailed knowledge of the existing geology, besides to take into account a helpful method, to increase the studied zones, optimizing ins such a way, the obtained results, found with another exploration techniques. (author). 4 refs., 4 figs., 4 tabs.

  15. The Environmental Benefits and Costs of Genetically Modified (GM) Crops

    NARCIS (Netherlands)

    Wesseler, J.H.H.; Scatasta, S.; Fall, E.H.

    2011-01-01

    The widespread introduction of genetically modified (GM) crops may change the effect of agriculture on the environment. The magnitude and direction of expected effects are still being hotly debated, and the interests served in this discussion arena are often far from those of science and social welf

  16. Public Acceptance of Plant Biotechnology and GM Crops.

    Science.gov (United States)

    Lucht, Jan M

    2015-07-30

    A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the divergent paths-also affecting the development of virus resistant transgenic crops-of political and regulatory frameworks for GM crops and food in different parts of the world. These have also shaped the different opinions of consumers. Important factors influencing consumer's attitudes are the perception of risks and benefits, knowledge and trust, and personal values. Recent political and societal developments show a hardening of the negative environment for agricultural biotechnology in Europe, a growing discussion-including calls for labeling of GM food-in the USA, and a careful development in China towards a possible authorization of GM rice that takes the societal discussions into account. New breeding techniques address some consumers' concerns with transgenic crops, but it is not clear yet how consumers' attitudes towards them will develop. Discussions about agriculture would be more productive, if they would focus less on technologies, but on common aims and underlying values.

  17. Public Acceptance of Plant Biotechnology and GM Crops

    Directory of Open Access Journals (Sweden)

    Jan M. Lucht

    2015-07-01

    Full Text Available A wide gap exists between the rapid acceptance of genetically modified (GM crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the divergent paths—also affecting the development of virus resistant transgenic crops—of political and regulatory frameworks for GM crops and food in different parts of the world. These have also shaped the different opinions of consumers. Important factors influencing consumer’s attitudes are the perception of risks and benefits, knowledge and trust, and personal values. Recent political and societal developments show a hardening of the negative environment for agricultural biotechnology in Europe, a growing discussion—including calls for labeling of GM food—in the USA, and a careful development in China towards a possible authorization of GM rice that takes the societal discussions into account. New breeding techniques address some consumers’ concerns with transgenic crops, but it is not clear yet how consumers’ attitudes towards them will develop. Discussions about agriculture would be more productive, if they would focus less on technologies, but on common aims and underlying values.

  18. Effects of GM crops on non-target organisms

    Science.gov (United States)

    Crop genetically engineered to provide resistance to specific groups of insect pests have been adopted by millions of growers throughout the world. GM crops have become important tools in crop production and protection in many countries and contribute significantly to overall IPM programs. There, ...

  19. EU Regulations Impede Market Introduction of GM Forest Trees.

    Science.gov (United States)

    Custers, René; Bartsch, Detlef; Fladung, Matthias; Nilsson, Ove; Pilate, Gilles; Sweet, Jeremy; Boerjan, Wout

    2016-04-01

    Biotechnology can greatly improve the efficiency of forest tree breeding for the production of biomass, energy, and materials. However, EU regulations impede the market introduction of genetically modified (GM) trees so their socioeconomic and environmental benefits are not realized. European policy makers should concentrate on a science-based regulatory process. PMID:26897457

  20. Societal aspects of foods derived from GM crops

    DEFF Research Database (Denmark)

    Beekmann, V.; Frewer, L.F.; Lassen, J.;

    2004-01-01

    The first major controversy associated with gene technology in Europe took place in the late 1980s. At this time, there were no products actually being sold to consumers. In 1996, controversy over gene technology was triggered by the arrival of GM soybeans at European harbours. The soybeans, comi...... on transgenic crops, as did other biotechnology applications, such as animal and human cloning....

  1. Pathology of GM2 gangliosidosis in Jacob sheep.

    Science.gov (United States)

    Porter, B F; Lewis, B C; Edwards, J F; Alroy, J; Zeng, B J; Torres, P A; Bretzlaff, K N; Kolodny, E H

    2011-07-01

    The G(M2) gangliosidoses are a group of lysosomal storage diseases caused by defects in the genes coding for the enzyme hexosaminidase or the G(M2) activator protein. Four Jacob sheep from the same farm were examined over a 3-year period for a progressive neurologic disease. Two lambs were 6-month-old intact males and 2 were 8-month-old females. Clinical findings included ataxia in all 4 limbs, proprioceptive deficits, and cortical blindness. At necropsy, the nervous system appeared grossly normal. Histologically, most neurons within the brain, spinal cord, and peripheral ganglia were enlarged, and the cytoplasm was distended by foamy to granular material that stained positively with Luxol fast blue and Sudan black B stains. Other neuropathologic findings included widespread astrocytosis, microgliosis, and scattered spheroids. Electron microscopy revealed membranous cytoplasmic bodies within the cytoplasm of neurons. Biochemical and molecular genetic studies confirmed the diagnosis of G(M2) gangliosidosis. This form of G(M2) gangliosidosis in Jacob sheep is very similar to human Tay-Sachs disease and is potentially a useful animal model. PMID:21123862

  2. Public Acceptance of Plant Biotechnology and GM Crops.

    Science.gov (United States)

    Lucht, Jan M

    2015-08-01

    A wide gap exists between the rapid acceptance of genetically modified (GM) crops for cultivation by farmers in many countries and in the global markets for food and feed, and the often-limited acceptance by consumers. This review contrasts the advances of practical applications of agricultural biotechnology with the divergent paths-also affecting the development of virus resistant transgenic crops-of political and regulatory frameworks for GM crops and food in different parts of the world. These have also shaped the different opinions of consumers. Important factors influencing consumer's attitudes are the perception of risks and benefits, knowledge and trust, and personal values. Recent political and societal developments show a hardening of the negative environment for agricultural biotechnology in Europe, a growing discussion-including calls for labeling of GM food-in the USA, and a careful development in China towards a possible authorization of GM rice that takes the societal discussions into account. New breeding techniques address some consumers' concerns with transgenic crops, but it is not clear yet how consumers' attitudes towards them will develop. Discussions about agriculture would be more productive, if they would focus less on technologies, but on common aims and underlying values. PMID:26264020

  3. GM food nightmare unfolding in the regulatory sham

    OpenAIRE

    Ho, Mae-Wan; Cummins, Joe; Saunders, Peter

    2011-01-01

    Our regulators are ignoring the precautionary principle, manipulating and corrupting science, sidestepping the law, and helping to promote genetically modified organisms (GMOs) in the face of massive public opposition and damning evidence piling up against the safety of genetically modified (GM) food and feed.

  4. Bright Sparks of Our Future!

    Science.gov (United States)

    Riordan, Naoimh

    2016-04-01

    My name is Naoimh Riordan and I am the Vice Principal of Rockboro Primary School in Cork City, South of Ireland. I am a full time class primary teacher and I teach 4th class, my students are aged between 9-10 years. My passion for education has developed over the years and grown towards STEM (Science, Technology, Engineering and Mathematics) subjects. I believe these subjects are the way forward for our future. My passion and beliefs are driven by the unique after school programme that I have developed. It is titled "Sparks" coming from the term Bright Sparks. "Sparks" is an after school programme with a difference where the STEM subjects are concentrated on through lessons such as Science, Veterinary Science Computer Animation /Coding, Eco engineering, Robotics, Magical Maths, Chess and Creative Writing. All these subjects are taught through activity based learning and are one-hour long each week for a ten-week term. "Sparks" is fully inclusive and non-selective which gives all students of any level of ability an opportunity to engage into these subjects. "Sparks" is open to all primary students in County Cork. The "Sparks" after school programme is taught by tutors from the different Universities and Colleges in Cork City. It works very well because the tutor brings their knowledge, skills and specialised equipment from their respective universities and in turn the tutor gains invaluable teaching practise, can trial a pilot programme in a chosen STEM subject and gain an insight into what works in the physical classroom.

  5. Designers predict a bright future

    International Nuclear Information System (INIS)

    As power plant designers and builders, there is a bright future for the industry. The demand for electricity will continue to grow, and the need for new plants will increase accordingly. But companies that develop and supply these plants must adapt to new ways of doing business if they expect to see the dawn of this new age. Several factors will have a profound effect on the generation and use of electricity in future years. Instant communications now reach all corners of the globe, making people everywhere aspire to a higher standard of living. The economic surge needed to satisfy these appetites will, in turn, be fed by a network of suppliers who are themselves restructuring to serve global markets, unimpeded by past nationalistic barriers to trade. The strong correlation between economic progress and the growing demand for electricity is well recognized. A ready supply of affordable electricity is a necessary underpinning for any economic expansion. As economies advance and jobs increase, electric demand grows geometrically, fueled by an ever-improving quality of life. Coupled with increasing demand is the worldwide trend toward privatization of the generation industry. The reasons may vary in different parts of the world, but the effect is the same--companies are battling intensely for the right to build or purchase generating facilities. Those companies, like the industry they serve, are themselves in a period of transition. Once a closed, monopolistic group of owners in a predominantly services-based market, they are, thanks to competitive forces, being driven steadily toward a product-based structure

  6. Health and working conditions of high school and university teachers in Mendoza: between commitment and emotional distress

    Directory of Open Access Journals (Sweden)

    Patricia Alejandra Collado

    2016-06-01

    Full Text Available Con el objetivo de analizar los aspectos vinculados con la percepción sobre las condiciones de trabajo y su impacto en la salud de los docentes que pertenecen a la Universidad Nacional de Cuyo (UNCuyo, Mendoza, Argentina, este artículo analiza los resultados del Primer Censo de Condiciones y Salud Laboral, realizado a fines del año 2013, en dos unidades académicas (una de enseñanza media y otra de nivel universitario que abarcó a 193 docentes. El sondeo se dedicó a caracterizar el plantel de trabajadores/as y las condiciones que afectan su salud, principalmente en sus aspectos psicosociales, para lo cual se aplicó un cuestionario autoadministrado, cuyas dimensiones fueron debatidas en talleres de sensibilización con docentes que colaboraron en la preparación del instrumento de recolección. Entre sus principales resultados emerge el desgaste físico y emocional de trabajadores altamente calificados, por el efecto combinado de la respuesta comprometida a las exigencias de su labor con la degradación (material y simbólica de las condiciones en que la desempeña.

  7. Fission-track dating of the punta de vacas glaciation in the Rı´o Mendoza valley, Argentina.

    Science.gov (United States)

    Espizua, L. E.; Bigazzi, G.

    Fission-track dating of three tephra samples related to mappable drifts and non-glacial sediments, including alluvium, in the Rı´o Mendoza valley, Argentina, places limiting ages on the oldest two glacial events. A tephra-layer interstratified with fan alluvium that surrounds and cuts the outermost Uspallata moraine has an age of 170,000±50,000 yr, implying that the drift predates marine oxygen isotope stage (OIS) 6. A tephra dated at 134,000±32,000 yr, that was deposited on alluvial fan sediments, underlies Punta de Vacas drift, which is inferred to equate with Isotope Stage 6. The Punta de Vacas outwash, which likely correlates with the Rı´o Colorado drift, overlies another tephra unit that dates to 260,000±150,000 yr. Although the error limits of the dates preclude definitive correlations, all three tephra units may have been deposited during an interval prior to the maximum advance of the Punta de Vacas glaciation during OIS 6 or maybe in the Stage 7 interglacial period.

  8. Flujos de detritos recientes en la cordillera frontal de Mendoza: Un ejemplo de riesgo natural en la ruta 7

    Directory of Open Access Journals (Sweden)

    Emmanuel Wick

    2010-06-01

    Full Text Available Se expone un estudio sobre los flujos de detritos ocurridos en enero de 2005, en el km 1.118,5 de la ruta nacional 7 en la provincia de Mendoza. La zona se ubica en la Cordillera Frontal, próxima al límite con la Precordillera. Se realizó un mapa geomorfológico detallado, sobre la base de una imagen Quickbird del año 2006. Además, se hicieron cálculos de volúmenes, velocidades y caudales, con mediciones en el campo y con ayuda de un sistema de información geográfico (SIG. El estudio de la geomorfología permitió proponer tres escenarios para el caso de un nuevo evento, a partir de los cuáles se creó un mapa de susceptibilidad a los flujos de detritos para el tramo de ruta analizado. Finalmente, se proponen medidas de protección y de mitigación ante la posibilidad de recurrencia de estos eventos en el sector.

  9. Genesis of sandstone-type uranium deposits in the Sierra Pintada district, Mendoza, Argentina: a Moessbauer study

    International Nuclear Information System (INIS)

    The genesis of sandstone-type uranium deposits in the Cochico Group (Permo-Triassic) of the Sierra Pintada district, San Rafael, Mendoza, has been studied. This is the most important uranium district in Argentina. Uranium sources, uranium transport and precipitation are discussed. Uraninite and brannerite, the main uranium minerals, occur within the matrix of sandstone. Several phenomena can be deduced regarding the depositional environment. Where oxygen was available, precipitation of hydrated ferric oxides occurred; γFe2O3.nH2O varieties (identified by Moessbauer spectroscopy) precipitated in the upper levels of the aquifer, where CO2 partial pressure was lower, giving reddish or reddish-brown beds. The CO2 partial pressure also determines the distribution of biogenic agents such as bacteria. Bacteria thus find a more favourable environment for their development and action in upper levels of an aquifer. In the corresponding horizons local reduction occurred where UO2 precipitated; therefore the highest uranium concentrations correspond to sandstone levels with reddish or reddish-brown pigment. These pigments have been identified by Moessbauer spectroscopy. (Auth.)

  10. Análisis del campo de esfuerzos en una secuencia lacustre de Precordillera oriental, San Juan-Mendoza

    Directory of Open Access Journals (Sweden)

    Laura P. Perucca

    2008-06-01

    Full Text Available En la quebrada del río Acequión, ubicada en el sur de la provincia de San Juan y norte de Mendoza (32º 10' S, en el centrooeste argentino, se efectuó el análisis de las fallas que afectan depósitos lacustres de edad holocena. Estas fallas se encuentran asociadas a estructuras de licuefacción y avalanchas de roca indicadoras de paleoterremotos, lo que permite extender el registro sísmico de la región hasta el Holoceno temprano. Al comparar el campo de esfuerzos regional actual (determinado por sismicidad instrumental, con el cálculo del mecanismo focal de los terremotos recientes ocurridos en la región con el campo de esfuerzos local, se observó que mientras el primero se caracteriza por la compresión, el campo local de la secuencia lacustre es extensional. Esto indicaría que aunque el esfuerzo regional actual es compresivo y de dirección NE-SO debido a la convergencia entre las placas de Nazca y Sudamérica, el antiguo lago adosado a las sierras de Pedernal y Los Pozos, está afectado por fallas normales, principalmente debido a esfuerzos locales distensivos originados por el reacomodamiento de estos depósitos durante el levantamiento de las zonas montañosas aledañas.

  11. Plantas Fósiles del Grupo Choiyoi, Cordillera Frontal a la Latitud del río Mendoza

    Directory of Open Access Journals (Sweden)

    Magdalena Koukharsky

    2011-06-01

    Full Text Available En este trabajo se dan a conocer los primeros restos fósiles hallados en sedimentitas, cuyo componente clástico es de origen volcánico, intercaladas en la Formación Tambillos del Grupo Choiyoi, Cordillera Frontal de Mendoza. Los mismos consisten en abundantes improntas de Sphenophyta en estado de preservación regular a malo. En la zona estudiada, las rocas de la Formación Tambillos, que son dominantemente volcánicas ácidas y de edad pérmica temprana a media según correlaciones regionales, se depositaron sobre una discordancia erosiva labrada en lavas andesíticas intensamente propilitizadas que se atribuyen a la Formación Portezuelo del Cenizo. Los restos vegetales se encuentran a unos 23 metros de la base, contenidos en niveles de areniscas finas y pelitas depositadas en un ambiente fluvial (microdelta, en los bordes de un lago y fueron coetáneas con los primeros episodios de volcanismo riolítico en la región. Si bien la flora encontrada no permite definir la edad, las formas presentes son comunes en niveles del Carbonífero superior-Pérmico y Triásico de Argentina.

  12. Capitalist modernization and poverty in Mendoza, Argentina. Agroindustrial development and working class life conditions, 1890-1918

    Directory of Open Access Journals (Sweden)

    Rodolfo Richard-Jorba

    2012-08-01

    Full Text Available During the last decade of the XIX century and the first two decades of the XX, the argentine province of Mendoza underwent substantial territorial, economical and society changes due to the advance of the capitalism, that formed one of the first regional economy of the country: the viticulture industry. The capitalist development produced an unknown economic expansion in which all the indicators increased in number: extent of the agrarian cultivation, wine vault installment, raise of the capacity of wine elaboration, technological improvement. Pertaining to society land subdivision, enterprise class arising and enlargement of the middle class. However, the majority of the popular sectors, enlarged by the overseas immigration, suffered life conditions characterized by low incomes which were maintained in face values during the studied period, and home and health problems that derived in the propagation of serious contagious disease and high children death rate. This article shows the contrast between a powerful productive forces development and the miserable conditions of population life.

  13. VER Y SER VISTO: METÁFORA DE LA MIRADA EN EL PERRO DE ESCRIBANA, DE MARÍA LUISA MENDOZA It sees and is seen: scopic metaphor in El perro de la escribana by María Luisa Mendoza

    Directory of Open Access Journals (Sweden)

    Mariana Libertad Suárez

    2011-12-01

    Full Text Available Este artículo propone una lectura de la novela El perro de la escribana (1982 de María Luisa Mendoza, un texto donde la arbitrariedad y la voluntad del sujeto --o, lo que es lo mismo, “su mirada”-- se establecerán como herramientas básicas para arraigar las identidades nacionales, culturales y de género. Por lo mismo, el valor del pasado, así como el de los discursos asociados al mismo, dependerá únicamente de la autoridad simbólica de quienes los enuncien.This article proposes an analysis of the novel “El perro de la escribana” (1982 by Maria Luisa Mendoza, a text in which arbitrary and subject’s gaze will become basic tools where national, cultural and gender identities take root. In this book, its past depends only on the symbolic authority of those speeches outlining the memory.

  14. Bright boys the making of information technology

    CERN Document Server

    Green, Tom

    2010-01-01

    Everything has a beginning. None was more profound-and quite as unexpected-than Information Technology. Here for the first time is the untold story of how our new age came to be and the bright boys who made it happen. What began on the bare floor of an old laundry building eventually grew to rival in size the Manhattan Project. The unexpected consequence of that journey was huge---what we now know as Information Technology. For sixty years the bright boys have been totally anonymous while their achievements have become a way of life for all of us. "Bright Boys" brings them home. By 1950 they'd

  15. The structure of bright zinc coatings

    Directory of Open Access Journals (Sweden)

    MIODRAG STOJANOVIC

    2000-11-01

    Full Text Available The structures of bright zinc coatings obtained from acid sulfate solutions in the presence of dextrin/salicyl aldehyde mixture were examined. It was shown by the STM technique that the surfaces of bright zinc coatings are covered by hexagonal zinc crystals, the tops of planes of which are flat and mutually parallel and which exhibit smoothness on the atomic level. X-Ray diffraction (XRD analysis of the bright zinc coatings showed that the zinc crystallites are oriented in the (110 plane only.

  16. GM Food Crop Technology and Trade Measures: Some Economic Implications for Australia and New Zealand

    OpenAIRE

    Kym Anderson; Lee Ann Jacskon

    2004-01-01

    How much might the potential economic benefit from a farm productivity boost associated with crop biotechnology adoption by Australia and New Zealand (ANZ) be offset by a loss of market access abroad for crops that may contain genetically modified (GM) organisms? This paper uses the global GTAP model to estimate effects of other countriesÂ’ GM policies without and with ANZ farmers adopting GM varieties of various grains and oilseeds. The gross economic benefits to ANZ from adopting GM crops u...

  17. GM food technology abroad and its implications for Australia and New Zealand

    OpenAIRE

    Anderson, Kym; Jackson, Lee Ann

    2004-01-01

    The potential economic benefits from agricultural biotechnology adoption by ANZ need to be weighed against any likely loss of market access abroad for crops that may contain genetically modified (GM) organisms. This paper uses the global GTAP model to estimate effects of other countries' GM policies without and with ANZ farmers adopting GM varieties of various grains and oilseeds. The benefits to ANZ from adopting GM crops under a variety of scenarios are positive even in the presence of the ...

  18. Comparison of Perception of Risk and Willingness to Consume GM Foods

    OpenAIRE

    Wachenheim, Cheryl J.; Nganje, William E.; Lesch, William C.

    2008-01-01

    The dichotomy between perceptions of the acceptability of risk associated with genetically modified (GM) foods and willingness to consume GM foods is investigated. Results indicate that some consumers are willing to consume GM foods even though they may perceive such foods as somewhat unsafe, with determinants such as self-perceived knowledge about the availability of GM foods and altruistic motives having positive and significant impacts on their consumption decision. Efforts towards decreas...

  19. Brightness of synchrotron radiation from wigglers

    CERN Document Server

    Geloni, Gianluca; Saldin, Evgeni

    2014-01-01

    According to literature, while calculating the brightness of synchrotron radiation from wigglers, one needs to account for the so called `depth-of-field' effects. In fact, the particle beam cross section varies along the wiggler. It is usually stated that the effective photon source size increases accordingly, while the brightness is reduced. Here we claim that this is a misconception originating from an analysis of the wiggler source based on geometrical arguments, regarded as almost self-evident. According to electrodynamics, depth-of-field effects do not exist: we demonstrate this statement both theoretically and numerically, using a well-known first-principle computer code. This fact shows that under the usually accepted approximations, the description of the wiggler brightness turns out to be inconsistent even qualitatively. Therefore, there is a need for a well-defined procedure for computing the brightness from a wiggler source. We accomplish this task based on the use of a Wigner function formalism. I...

  20. The solar brightness temperature at millimeter wavelengths

    Science.gov (United States)

    Kuseski, R. A.; Swanson, P. N.

    1976-01-01

    Measurements of the brightness temperature of the sun near 36 GHz and 93 GHz were made using the new moon as a calibration source. Provided the brightness temperature of the moon is known and all measurements are reduced to the same zenith angle, a simple expression can be used for the sun-to-new moon ratio which is independent of antenna gain, atmospheric absorption and reemission, and radiometer calibration constants. This ratio was measured near 36 GHz and at two frequencies near 93 GHz with a Dicke switched superheterodyne radiometer system and a 2.4 m Cassegrain antenna. The slopes of the solar brightness temperature spectrum based on these ratios were measured. The absolute solar brightness spectrum derived from all current available measurements supplemented by the present ones is also plotted and discussed.

  1. A spectroscopic atlas of bright stars

    CERN Document Server

    Martin, Jack

    2009-01-01

    Suitable for amateur astronomers interested in practical spectroscopy or spectrography, this reference book identifies more than 70 (northern hemisphere) bright stars that are suitable observational targets. It provides finder charts for locating these sometimes-familiar stars.

  2. Conflictos sociales en Mendoza entre dos crisis, 1890-1916: Una larga lucha de los trabajadores por la conquista de sus derechos laborales

    Directory of Open Access Journals (Sweden)

    Rodolfo Richard-Jorba

    2010-06-01

    Full Text Available Este artículo contribuye a la reconstrucción de la historia del mundo de los trabajadores en Mendoza. Las fuentes revisadas y la sistematización de información dispersa han permitido profundizar en los conocimientos hasta ahora generados, sacando a luz una parte significativa del desarrollo capitalista centrado en la agroindustria vitivinícola. Las fuentes principales para seguir los conflictos han sido los diarios mendocinos, por lo que nuestro abordaje constituye una aproximación que esperamos poder ampliar en el futuro. En este artículo presentamos los conflictos sociales en el contexto de períodos de crisis y de auge económico. Comenzamos por la crisis de 1890 y concluimos con la crisis provocada por la Primera Guerra Mundial y los cambios políticos que sobrevendrían a partir de 1916-1918This article contributes to reconstructing the history of the world of labour in Mendoza. The revision of sources and the systematization of the scattered information available resulted in a deeper insight on the subject and a better understanding of capitalist development based on vitivicultural agroindustry. Articles from Mendoza newspapers have been the main historical sources used to follow these conflicts, and are expected to be widened in future investigations. Currently, social troubles are presented in a context of a period of economic growth and crisis. We start with the crisis of 1890, to conclude with the World War I crisis and the political changes that would come after 1916-1918

  3. Development of a high brightness ion source

    International Nuclear Information System (INIS)

    The brightness and emittance of an ion beam can depend on the ion temperature, aberrations and scattering, as well as other factors. However, it is the ion temperature which determines the irreducible minimum value of the emittance and hence brightness, as the other components can be eliminated by careful design. An ion source design is presented which has attained this minimum value for the emittance; the dependence of the ion temperature on the plasma source parameters is discussed

  4. Observations and diagnostics in high brightness beams

    Science.gov (United States)

    Cianchi, A.; Anania, M. P.; Bisesto, F.; Castellano, M.; Chiadroni, E.; Pompili, R.; Shpakov, V.

    2016-09-01

    The brightness is a figure of merit largely used in the light sources, like FEL (Free Electron Lasers), but it is also fundamental in several other applications, as for instance Compton backscattering sources, beam driven plasma accelerators and THz sources. Advanced diagnostics are essential tools in the development of high brightness beams. 6D electron beam diagnostics will be reviewed with emphasis on emittance measurement.

  5. State modernization and economic regulation in the provinces winemakers. Mendoza, 1936-1946 Modernización estatal y regulación económica en provincias vitivinicultoras. Mendoza, 1936-1946

    Directory of Open Access Journals (Sweden)

    María Silvia Ospital

    2009-01-01

    Full Text Available The policies implemented in the country to overcome the consequences of the crisis of 1930 were measures to regulate production and trade, in the case of agricultural activities and industries. The entity created to handle the winemaking was Junta Reguladora de Vinos, which began operations after 1935. At the same time that they put into execution the provisions adopted by this national institution, the provincial authorities in the producing region arbitrated various practices designed to offset the sharper edges of the crisis and to reposition the agricultural industry at local and national market. In the province of Mendoza provincial authorities prescribed, starting in 1936, some regulations aimed at modernizing the state apparatus in an attempt to achieve greater efficiency in the implementation of regulatory policies and making the machinery of government to the demands of the new stage. The creation of a office specifically dedicated to the production of statistics and economic research under the provincial Ministry of Finance was the most important measure in this regard, while other provisions were trying to find in contemporary tourism development of a complementary alternative traditional winesLas políticas implementadas en el país para superar las consecuencias de la crisis de 1930 se manifestaron, en el caso de las actividades agrarias y agroindustriales, en medidas de regulación de la producción y el comercio. La entidad creada para ocuparse de la vitivinicultura fue la Junta Reguladora de Vinos que comenzó a operar a partir de 1935. Al mismo tiempo que se ponían en ejecución las disposiciones emanadas de ese organismo nacional, las autoridades provinciales de la región productora arbitraban diversas prácticas destinadas a paliar las aristas más agudas de la crisis y a reposicionar a la agroindustria en el ámbito local y el mercado nacional. En la provincia de Mendoza las autoridades provinciales instrumentaron, a partir

  6. Oncoides tipo Osagia en la Formación La Manga (Oxfordiano y su significado paleoecológico, arroyo La Vaina, Mendoza Osagids-types oncoids from La Manga Formation and their paleoecological significance, La Vaina Creek, Mendoza

    Directory of Open Access Journals (Sweden)

    R.M. Palma

    2007-11-01

    Full Text Available Oncoides microbianos fueron encontrados en calizas del Oxfordiano de la Formación La Manga en la sección del Arroyo La Vaina, provincia de Mendoza. Los oncoides se presentan en packstones, floatstones-rudstones o dispersos en wackestones. Presentan formas elípticas, ameboidales y esféricas. Se reconocieron diferentes tipos de oncoides de acuerdo a las características de sus envolturas: (1 laminaciones micríticas, (2 laminaciones grumosas, y (3 laminaciones con organismos incrustantes. Sus núcleos están representados por fragmentos de moluscos, equinoideos, peloides e intraclastos. La envoltura sigue la forma del núcleo en la zona interna de la corteza. Sin embargo, en las zonas externas, la laminación contiene organismos incrustantes dominados por nubeculáridos y serpúlidos. Algunos oncoides, especialmente las formas ameboidales y elípticas, están caracterizados por múltiples núcleos, representados por oncoides pequeños. Los oncoides aparecen conjuntamente con bivalvos, equinodermos, foraminíferos y serpúlidos. La fauna indica condiciones someras, tranquilas, y la excelente preservación de los equinodermos sugiere mínimo transporte antes del enterramiento. Los oncoides crecieron en un ambiente marino normal, en el sector submareal, de aguas someras, con agitación leve a moderada. El limitado rolido en el crecimiento de los oncoides probablemente fue acompañado por corrientes intermitentes que reorientaron los oncoides paralelos a la estratificación. La laminación discontinua con organismos incrustantes refleja períodos de no agitación y litificación que facilitaron el crecimiento de organismos incrustantes sobre oncoides estáticos durante un período de baja tasa de sedimentación. La depositación de calizas con oncoides ocurrió durante la somerización del intervalo carbonático, asociada con la emersión, exposición subaérea y desarrollo de un paleokarst, como consecuencia de fluctuaciones relativas del nivel

  7. Petrografía y geoquímica de las rocas gondwánicas del proyecto minero Don Sixto, Mendoza Petrography and geochemistry of the gondwanic rock units from Don Sixto mining project, Mendoza

    Directory of Open Access Journals (Sweden)

    Ana Cecilia Mugas Lobos

    2010-11-01

    Full Text Available El proyecto minero Don Sixto es un depósito epitermal de Au-Ag de baja sulfuración ubicado al sureste de la provincia de Mendoza; el recurso aurífero de este depósito es próximo a las 900.000 onzas. La mineralización en el área se encuentra principalmente diseminada y está alojada mayormente en volcanitas y piroclastitas riolíticas de la Formación Choique Mahuida y diques riolíticos del Grupo El Portillo, ambos representantes de la sección superior del Grupo Choiyoi. Los datos obtenidos por el relevamiento geológico y los estudios petrográficos realizados en las volcanitas-piroclastitas del área de estudio, permiten indicar que la Formación Choique Mahuida está representada por riolitas, intercaladas con mantos ignimbríticos y niveles aislados de depósitos lenticulares piroclásticos. Por su parte, los diques riolíticos del Grupo El Portillo, de rumbo general noroeste-sureste y norte-sur, están probablemente vinculados a la evolución de zonas de falla de carácter regional. La geoquímica de estas riolitas gondwánicas, de acuerdo a la distribución de sus elementos traza y tierras raras, indica que están genéticamente vinculadas entre sí y pertenecerían a una suite cosanguínea proveniente de magmas diferenciados más evolucionados que los conocidos hasta la fecha para rocas de la sección superior del Grupo Choiyoi. Las características geoquímicas de estos magmas concuerdan además con los datos conocidos para rocas equivalentes fuera del área de estudio, en base a los cuales se asigna la sección superior del Grupo a un ambiente geotectónico transicional entre uno de arco volcánico y uno de intraplaca.Don Sixto mining project is a low sulphidation epithermal Au-Ag ore deposit located at the southeast of Mendoza province; the gold resource of the deposit is close to 900.000 ounces. In the study area, the mineralization is mainly disseminated and it is hosted by rhyolitic volcanic and pyroclastic sequences of the

  8. Inserciones laborales tempranas: Los jóvenes trabajadores agrícolas en el Valle de Uco, Mendoza, Argentina Early labor markets incorporations: Agricultural young workers in the Uco Valley, Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Gabriel I Bober

    2011-06-01

    Full Text Available Este artículo presenta las diferentes formas de inserción laboral de trabajadores jóvenes en el Valle de Uco, en la provincia de Mendoza. Durante las últimas décadas, el Valle de Uco basó su patrón de desarrollo agrícola en un modelo intensivo y empresarial de sus tres principales cultivos: los viñedos, los frutales y las hortalizas. En la actualidad, atraviesa un proceso de profunda reconversión productiva, orientada mayoritariamente hacia el mercado externo, que entre otras consecuencias pasó a modificar el funcionamiento del mercado de trabajo local. En este artículo, se contemplan las diferentes situaciones que llevan al ingreso laboral de los jóvenes en este contexto, según el momento etáreo que atraviesen. Se analiza la relación que este proceso guarda con el tamaño y la estructura de las familias y la situación socio-económica del hogar al que pertenecen. También, se examina el vínculo entre las características de los hogares y la forma de inserción de los jóvenes en el mercado de trabajo, de acuerdo al tipo de ocupación en la que se desempeñan y al destino que le dan a sus ingresos. A partir de la realización de entrevistas en profundidad a trabajadores jóvenes y a informantes clave se pudo dar cuenta de las preferencias de los jóvenes con respecto a distintos tipos de trabajos, con particular énfasis en ciertos trabajos agrícolas y, también en relación a su futuro laboral.This article deals with the different ways that young workers in the Uco Valley, at the province of Mendoza, enter to the agrarian local labour market. During the last decadas, the Uco Valley based its pattern of agricultural development in an intensive business model of its three main crops: vineyards, orchards, and vegetables. Currently, it is undergoing a process of profound restructuring of production, mainly oriented towards foreign markets, which among different consequences has modified the functioning of local labour markets. In

  9. Control estructural en la distribución de las mineralizaciones de uranio del ciclo Choiyoi, bloque de San Rafael, Mendoza Structural control on the distribution of uranium mineralizations of the Choiyoi cycle, San Rafael Massif, Mendoza

    Directory of Open Access Journals (Sweden)

    María S. Japas

    2008-06-01

    Full Text Available Las mineralizaciones más importantes del distrito uranífero Sierra Pintada (Bloque de San Rafael, Mendoza se asocian a las rocas pertenecientes al ciclo magmático Choiyoi. En la sección inferior de este ciclo predominan los yacimientos alojados en areniscas de origen epiclástico. En la sección superior, en cambio, se encuentran pequeñas mineralizaciones vetiformes de escasa importancia económica. Durante el emplazamiento y la acumulación de estas volcanitas y sedimentitas pérmicas prevalecieron dos regímenes de esfuerzo diferentes: transpresional (fase orogénica San Rafael y transtensional (etapa postorogénica, los cuales condicionaron los sistemas mineralizantes. Mediante un estudio de fábrica deformacional se evaluó el grado de control ejercido por las estructuras sobre la distribución de las mineralizaciones de uranio durante estas dos etapas de deformación. De esta forma, se intenta aportar nuevos conocimientos sobre la génesis de estos depósitos en la provincia magmática Choiyoi y generar nuevas guías de exploración. A través de este análisis se pudieron definir tres órdenes de magnitud en el control estructural sobre los depósitos asociados al ciclo Choiyoi inferior, cuyo desarrollo fue condicionado por la fábrica de la fase orogénica sanrafaélica. En el caso de las mineralizaciones alojadas en rocas de la sección superior del ciclo Choiyoi, el campo transtensional post-sanrafaélico ejerció un control, directo o indirecto, durante el proceso mineralizante.The main mineralizations of the Sierra Pintada uranium district, San Rafael Massif, Mendoza, are associated with the Choiyoi volcanic province. In the lower section of this magmatic cycle uranium deposits hosted by epiclastic sandstones are predominant. In the upper section, small vein-type deposits of low economic significance are found instead. During the emplacement of these Permian volcanic and sedimentary sequences two different stress regimes, which

  10. Consumer Valuation of the Second Generation of Genetically Modified (GM) Foods with Benefits Disclosure

    OpenAIRE

    Han, Jae-Hwan; Harrison, R. Wes

    2006-01-01

    Employing contingent valuation method (CVM), the study explores whether or not consumers risk/benefit beliefs and knowledge about GM foods affect their behavior as measured by willingness to pay (WTP) a premium for GM beef with benefits. The results demonstrate that risk/benefit perceptions play a significant role to elicit WTP for GM beef with benefits

  11. 5 CFR 531.245 - Computing locality rates and special rates for GM employees.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Computing locality rates and special... Gm Employees § 531.245 Computing locality rates and special rates for GM employees. Locality rates and special rates are computed for GM employees in the same manner as locality rates and special...

  12. A GM cryocooler with cold helium circulation for remote cooling

    Science.gov (United States)

    Wang, Chao; Brown, Ethan

    2014-01-01

    A GM cryocooler with new cold helium circulation system has been developed at Cryomech. A set of check valves connects to the cold heat exchanger to convert a small portion of AC oscillating flow in the cold head to a DC gas flow for circulating cold helium in the remote loop. A cold finger, which is used for remote cooling, is connected to the check valves through a pair of 5 m long vacuum insulated flexible lines. The GM cryocooler, Cryomech model AL125 having 120 W at 80 K, is employed in the testing. The cold finger can provide 50 W at 81 K for the power input of 4.1 kW and 70.5 W at 81.8 K for the power input of 6 kW. This simple and low cost design is very attractive for some applications in the near future.

  13. OpenGM: A C++ Library for Discrete Graphical Models

    CERN Document Server

    Andres, Bjoern; Kappes, Joerg H

    2012-01-01

    OpenGM is a C++ template library for defining discrete graphical models and performing inference on these models, using a wide range of state-of-the-art algorithms. No restrictions are imposed on the factor graph to allow for higher-order factors and arbitrary neighborhood structures. Large models with repetitive structure are handled efficiently because (i) functions that occur repeatedly need to be stored only once, and (ii) distinct functions can be implemented differently, using different encodings alongside each other in the same model. Several parametric functions (e.g. metrics), sparse and dense value tables are provided and so is an interface for custom C++ code. Algorithms are separated by design from the representation of graphical models and are easily exchangeable. OpenGM, its algorithms, HDF5 file format and command line tools are modular and extendible.

  14. Espectro trófico de Chelonoidis chilensis (Chelonii: Testudinidae en la provincia fitogeográfica del monte (Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Richard, Enrique

    1994-01-01

    Full Text Available Between 1983 and 1991, 83 field trips were made to the biogeographical province of Monte, in Mendoza province, Argentina, in order to study the trophic spectrum of Chelonoidis chilensis, among other ecoethological aspects. The trophic period extends from September to April. Adults are herbivorous in strict sense, but this may change according to the available resourees. Trophic spectrum is composed by 14 items (Families of vegetables. Some items have toxic or potentially toxit substances. Finally, the diet of Ch. chilensis is compared with the one of Ch. donosobarrosi and with other desert tortoises.

  15. Manuel Tolosa Latour (1857-1919 y Elisa Mendoza Tenorio (1856-1929: precursores de la protección a la infancia en España

    Directory of Open Access Journals (Sweden)

    Juan Félix Rodríguez Pérez

    2014-10-01

    La famosa actriz Elisa Mendoza Tenorio, esposa de Manuel Tolosa Latour, abandonó la escena teatral y se unió a la campaña de su marido. Estableció premios de higiene y fundó instituciones dedicadas a divulgar las normas higiénicas domésticas. Junto a Tolosa participó en la Sociedad Protectora de los Niños, él como secretario general y ella como integrante destacada de la Junta de Damas de la institución benéfica.

  16. LA PARTICIPACIÓN DE LAS MUJERES EN LA REVOLUCIÓN MEXICANA: JUANA BELÉN GUTIÉRREZ DE MENDOZA (1875-1942)

    OpenAIRE

    Ana Lau Jaiven

    2005-01-01

    Este artículo constituye una biografía de una revolucionaria y las etapas por las cuales transita su pensamiento. Juana B. Gutiérrez de Mendoza nacida en el estado de Durango, participó destacadamente en la historia de las mujeres en México debido a su oposición al régimen dictatorial de Porfirio Díaz. Se dedicó al magisterio y al periodismo como muchas mujeres de su tiempo. Atacó furiosamente a la religión y pugnó por la educación para las mujeres.

  17. "La verdad sobre el caso Savolta" de Eduardo Mendoza: cartografía literaria de una ciudad o vivir en Barcelona entre 1917 y 1919

    OpenAIRE

    Gaye, Mame Malamine

    2008-01-01

    En la verdad sobre el caso Savolta, Eduardo Mendoza nos propone una reconstrucción memorística de los hechos (el anarquismo, el pistolerismo, el periodismo político, los antagonismos sociales y los conflictos laborales) que hicieron del bienio 1917-1919 un período muy conflictivo. Esta escenificación histórica refuerza la ilusión de verdad que se destaca del cuadro porque hace verosímil el relato dejado en manos de unas voces dispares que van de lo político a lo policiaco, de lo socio-económ...

  18. Evidencias de la zona de contacto entre los terrenos de Precordillera y Pie de Palo, Provincias de San Juan y Mendoza

    Directory of Open Access Journals (Sweden)

    Maximiliano García Torrejón

    2011-12-01

    Full Text Available Se realizó un estudio gravimétrico en la región norte de la cuenca Cuyana, entre las provincias de San Juan y Mendoza. Mediante relaciones de gradientes gravimétricos tales como señal analítica, Tilt y fase del Tilt, se observó un marcado gradiente, que fue interpretado como un cambio lateral de litologías, que coincidiría con el área de una probable paleosutura del margen proto-andino, que separa en el terreno compuesto de Cuyania, al terreno de Precordillera con el terreno de Pie de Palo.

  19. Sobrepeso y obesidad en relación a condiciones socio-ambientales de Niños residentes en San Rafael, Mendoza

    OpenAIRE

    Oyhenart, Evelia Edith; Navone, Graciela Teresa; Sugrañes, Nuria; Garraza, Mariela

    2011-01-01

    El exceso de peso representa un problema emergente en salud pública, su prevalencia varía según zona de residencia, nivel socio-económico, edad y sexo. El objetivo del trabajo fue analizar las prevalencias de sobrepeso y obesidad en niños urbanos y rurales del Departamento de San Rafael, Mendoza, en relación a las condiciones socio-ambientales. Se realizó un estudio antropométrico transversal en 1176 individuos de 6 a 12 años. Se relevaron peso corporal, talla y pliegues subcutáneos tricipita...

  20. Viticultura agroecológica en la provincia de Mendoza : Razones de su adopción y consecuencias de la experiencia

    OpenAIRE

    Van den Bosch, María Eugenia; Abraham, Laura; Alturria, Laura

    2015-01-01

    La adopción de prácticas agroecológicas y la producción orgánica son de interés en la viticultura de la Provincia de Mendoza, Argentina. El presente trabajo tiene por objetivo reconocer los motivos que movilizaron el cambio y factores asociados, recabar sobre la valuación de la experiencia realizada y la percepción de las mejoras observadas en el emprendimiento. La información fue recogida censalmente a través de encuestas en todos los oasis provinciales. La mejora en el precio de la uva, la ...

  1. Tanzanian farmers' knowledge and attitudes to GM biotechnology and the potential use of GM crops to provide improved levels of food security. A Qualitative Study

    OpenAIRE

    Herron Caroline M; Newell James N; Lewis Christopher P; Nawabu Haidari

    2010-01-01

    Abstract Background Genetically Modified (GM) crops have been championed as one possible method to improve food security and individual nutritional status in sub Saharan Africa. Understanding and acceptability of GM crop technology to farmers and consumers have not been assessed. We developed a qualitative research study involving farmers as both producers and consumers to gauge the understanding of GM crop technology, its acceptability, and identifying issues of concern. Methods Nineteen ind...

  2. A Cell Free Assay System Estimating the Neutralizing Capacity of GM-CSF Antibody using Recombinant Soluble GM-CSF Receptor

    OpenAIRE

    Urano, Shinya; Tazawa, Ryushi; Nei, Takahito; Motoi, Natsuki; Watanabe, Masato; Igarashi, Takenori; Tomita, Masahiro; Nakata, Koh

    2011-01-01

    BACKGROUNDS: Previously, we demonstrated that neutralizing capacity but not the concentration of GM-CSF autoantibody was correlated with the disease severity in patients with autoimmune pulmonary alveolar proteinosis (PAP)1-3. As abrogation of GM-CSF bioactivity in the lung is the likely cause for autoimmune PAP4,5, it is promising to measure the neutralizing capacity of GM-CSF autoantibodies for evaluating the disease severity in each patient with PAP.

  3. Sustainability assessment of GM crops in a Swiss agricultural context

    OpenAIRE

    Speiser, Bernhard; Stolze, Matthias; Oehen,Bernadette; Gessler, Cesare; Weibel, Franco; Bravin, Esther; Kilchenmann, Adeline; Widmer, Albert; Charles, Raffael; Lang, Andreas; Stamm, Christian; Triloff, Peter; Tamm, Lucius

    2012-01-01

    International audience The aim of this study was to provide an ex ante assessment of the sustainability of genetically modified (GM) crops under the agricultural conditions prevailing in Switzerland. The study addressed the gaps in our knowledge relating to (1) the agronomic risks/benefits in production systems under Swiss conditions (at field and rotation/orchard level), (2) the economic and socio-economic impacts associated with altered farming systems, and (3) the agro-ecological risks/...

  4. Co-existence of Organic and GM Agriculture

    OpenAIRE

    Boelt, Birte

    2004-01-01

    The Danish Minister for Food, Agriculture and Fisheries presented in spring 2004 a bill on co-existence of genetically modified, conventional and organic crops in support of the free choice of consumers and to ensure development possibilities for new and existing production forms. The bill contains a framework for regulation based on crop specific control measures, communication among farmers and mandatory courses in GM cultivation. The identification of control measures is based on the repor...

  5. AMERICANS AND GM FOOD: KNOWLEDGE, OPINION AND INTEREST IN 2004

    OpenAIRE

    Hallman, William K.; Hebden, W. Carl; Cuite, Cara L.; Aquino, Helen L.; Lang, John T.

    2004-01-01

    This report presents the results from the third in a series of studies examining public perception of genetically modified (GM) food in the United States. All three studies were based on survey results of separate, nationally representative samples of approximately 1,200 Americans taken in 2001, 2003, and 2004. While the survey instrument on which the current report is based maintained many of the same measures of awareness and attitude as its two predecessors, it also included several new qu...

  6. Examining consumer behaviour toward genetically modified (GM) food in Britain

    OpenAIRE

    Spence, Alexa; Townsend, Ellen

    2006-01-01

    This study examined behaviour towards genetically modified (GM) food in a British community-based sample. We used an equivalent gain task in which participants actually received the options they chose to encourage truthful responding. In conjunction with this, theory of planned behaviour (TPB) components were evaluated so as to examine the relative importance of behavioural influences in this domain. Here the TPB was extended to include additional components to measure self-identity, moral no...

  7. Implicit attitudes towards Genetically Modified (GM) foods: a comparison of context-free and context-dependent evaluations

    OpenAIRE

    Spence, Alexa; Townsend, Ellen

    2006-01-01

    Past research on attitudes towards GM food has focused on measuring explicit attitudes. Here we compared implicit attitudes towards GM foods with explicit attitudes towards GM foods. We used the Go No-Go task to investigate context-free implicit evaluations of GM foods and compared these with evaluations made in the context of ordinary and organic foods. Semantic differential scales were used to evaluate explicit attitudes towards GM foods. As expected, explicit attitudes towards GM foods wer...

  8. GM Crops, Organic Agriculture and Breeding for Sustainability

    Directory of Open Access Journals (Sweden)

    Salvatore Ceccarelli

    2014-07-01

    Full Text Available The ongoing debate about the use of genetically-modified (GM crops in agriculture has largely focused on food safety and genetic contamination issues. Given that the majority of GM crops have been produced to respond to the problem of crop yield reductions caused by diseases, insects and weeds, the paper argues that in those cases, the currently used GM crops are an unstable solution to the problem, because they represent such a strong selection pressure, that pests rapidly evolve resistance. Organic agriculture practices provide a more sustainable way of producing healthy food; however, the lower yields often associated with those practices, making the resultant healthy food more expensive, open the criticism that such practices will not be able to feed human populations. Evolutionary plant breeding offers the possibility of using the evolutionary potential of crops to our advantage by producing a continuous flow of varieties better adapted to organic systems, to climate change and to the ever changing spectrum of pests, without depending on chemical control.

  9. Animal models of GM2 gangliosidosis: utility and limitations

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    Lawson CA

    2016-07-01

    Full Text Available Cheryl A Lawson,1,2 Douglas R Martin2,3 1Department of Pathobiology, 2Scott-Ritchey Research Center, 3Department of Anatomy, Physiology and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, AL, USA Abstract: GM2 gangliosidosis, a subset of lysosomal storage disorders, is caused by a deficiency of the glycohydrolase, β-N-acetylhexosaminidase, and includes the closely related Tay–Sachs and Sandhoff diseases. The enzyme deficiency prevents the normal, stepwise degradation of ganglioside, which accumulates unchecked within the cellular lysosome, particularly in neurons. As a result, individuals with GM2 gangliosidosis experience progressive neurological diseases including motor deficits, progressive weakness and hypotonia, decreased responsiveness, vision deterioration, and seizures. Mice and cats are well-established animal models for Sandhoff disease, whereas Jacob sheep are the only known laboratory animal model of Tay–Sachs disease to exhibit clinical symptoms. Since the human diseases are relatively rare, animal models are indispensable tools for further study of pathogenesis and for development of potential treatments. Though no effective treatments for gangliosidoses currently exist, animal models have been used to test promising experimental therapies. Herein, the utility and limitations of gangliosidosis animal models and how they have contributed to the development of potential new treatments are described. Keywords: GM2 gangliosidosis, Tay–Sachs disease, Sandhoff disease, lysosomal storage disorder, sphingolipidosis, brain disease

  10. Geiger-Muller (GM) counters. Associated circuits and counting techniques

    International Nuclear Information System (INIS)

    This article presents the Geiger-Muller counters which present the great benefit of being simple and steady in comparison with other known sensors. The authors propose an overview of problems related to the use of Geiger-Muller counters (GM counters). They first describe their operation (discharge initiation, discharge propagation, collection of positive ions and current in the counter). They discuss their limitations which are related to the migration delay of primary electrons and positive ions. They describe the operation circuit for counters with organic vapour, and for counters associated with counters using halogens. They address the main properties of GM counters, and the different factors to be taken into account when using them to count radioactive sources. The main types of GM counters are then described (they are used to measure different types of radiation). Measurement techniques are discussed for beta radiation (relationship between the number of disintegrations and the noticed counting rate, case of backscattering, absorption and diffusion in the counter window and in the air, influence of absorption and backscattering in the source), for alpha radiation, and for gamma radiation

  11. Energy-exchange collisions of dark-bright-bright vector solitons.

    Science.gov (United States)

    Radhakrishnan, R; Manikandan, N; Aravinthan, K

    2015-12-01

    We find a dark component guiding the practically interesting bright-bright vector one-soliton to two different parametric domains giving rise to different physical situations by constructing a more general form of three-component dark-bright-bright mixed vector one-soliton solution of the generalized Manakov model with nine free real parameters. Moreover our main investigation of the collision dynamics of such mixed vector solitons by constructing the multisoliton solution of the generalized Manakov model with the help of Hirota technique reveals that the dark-bright-bright vector two-soliton supports energy-exchange collision dynamics. In particular the dark component preserves its initial form and the energy-exchange collision property of the bright-bright vector two-soliton solution of the Manakov model during collision. In addition the interactions between bound state dark-bright-bright vector solitons reveal oscillations in their amplitudes. A similar kind of breathing effect was also experimentally observed in the Bose-Einstein condensates. Some possible ways are theoretically suggested not only to control this breathing effect but also to manage the beating, bouncing, jumping, and attraction effects in the collision dynamics of dark-bright-bright vector solitons. The role of multiple free parameters in our solution is examined to define polarization vector, envelope speed, envelope width, envelope amplitude, grayness, and complex modulation of our solution. It is interesting to note that the polarization vector of our mixed vector one-soliton evolves in sphere or hyperboloid depending upon the initial parametric choices. PMID:26764780

  12. Energy-exchange collisions of dark-bright-bright vector solitons

    Science.gov (United States)

    Radhakrishnan, R.; Manikandan, N.; Aravinthan, K.

    2015-12-01

    We find a dark component guiding the practically interesting bright-bright vector one-soliton to two different parametric domains giving rise to different physical situations by constructing a more general form of three-component dark-bright-bright mixed vector one-soliton solution of the generalized Manakov model with nine free real parameters. Moreover our main investigation of the collision dynamics of such mixed vector solitons by constructing the multisoliton solution of the generalized Manakov model with the help of Hirota technique reveals that the dark-bright-bright vector two-soliton supports energy-exchange collision dynamics. In particular the dark component preserves its initial form and the energy-exchange collision property of the bright-bright vector two-soliton solution of the Manakov model during collision. In addition the interactions between bound state dark-bright-bright vector solitons reveal oscillations in their amplitudes. A similar kind of breathing effect was also experimentally observed in the Bose-Einstein condensates. Some possible ways are theoretically suggested not only to control this breathing effect but also to manage the beating, bouncing, jumping, and attraction effects in the collision dynamics of dark-bright-bright vector solitons. The role of multiple free parameters in our solution is examined to define polarization vector, envelope speed, envelope width, envelope amplitude, grayness, and complex modulation of our solution. It is interesting to note that the polarization vector of our mixed vector one-soliton evolves in sphere or hyperboloid depending upon the initial parametric choices.

  13. Evaluation of summer thermal conditions and the environmental efficiency of different urban square designs in Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Susana Stocco

    2015-03-01

    Full Text Available El objetivo de este trabajo es evaluar las consecuencias de las decisiones de diseño sobre el comportamiento térmico y la eficiencia ambiental de las plazas de la ciudad de Mendoza. A tal fin se seleccionaron tres casos de estudio, donde se evaluó el comportamiento de distintas estructuras presentes en las plazas. Para ello se desarrollaron mediciones de temperatura del aire mediante sensores fijos, durante un periodo de 40 días en la estación verano de 2012, los sensores fueron ubicados en las diferentes estructuras (bosque, prado y centro de la plaza y en su entorno urbano, siguiendo un eje en sentido norte-sur. Además se determinó el valor del factor de visión de cielo (SVF y la digitalización hemisférica de la trayectoria solar para todos los puntos evaluados. Los resultados ponen de manifiesto la necesidad de reflexionar y revisar las estructuras de plazas existentes, en cuanto a sus esquemas de diseño, dado que el esquema tradicional que plantea una distribución de espacios en forma simétrica, parece no ser el que combina en forma más eficiente las distintas variables involucradas en el comportamiento térmico de la plaza: materialidad, distribución de la vegetación y exposición solar. Además se observa que a menor densidad edilicia del entorno urbano en el cual se inserta la plaza, sus condiciones térmicas y su eficiencia ambiental pueden mejorarse, casi con independencia de otros factores, mediante un diseño apropiado del espacio.

  14. Municipio, identidad cultural y comunidades indígenas. El caso huarpe en el noreste de Mendoza

    Directory of Open Access Journals (Sweden)

    Leticia Saldi

    2013-06-01

    Full Text Available En el presente artículo analizamos cómo funcionarios de la Municipalidad de Lavalle representan e interpelan a las comunidades indígenas huarpe situadas en el área no irrigada del noreste de Mendoza, área situada en el departamento de Lavalle. Éste se encuentra dividido socioterritorialmente en dos espacios. Uno irrigado, caracterizado como área de progreso, de producción agrícola y de herencia europea y el otro no irrigado, representado como área de atraso, de producción ganadera y de herencia precolonial. A partir de un análisis etnográfico, analizamos cómo el municipio gestiona local y cotidianamente la diversidad étnica, cultural, económica y política. Concluimos que las formas con que los funcionarios interpelan a las comunidades indígenas y a sus integrantes son en base a un doble movimiento, uno de reconocimiento explícito y el otro de individualización, invisibilización y deslegitimación hacia las mismas. Al invisibilizar a las comunidades como sujetos colectivos, funcionarios municipales intentan dar una identidad común que incorpore a los espacios irrigados y no irrigados y a sus poblaciones como pertenecientes a un mismo territorio, el departamental, a la vez que mantenga la jerarquización entre ambos. Al realizar este movimiento, el municipio se erige como el unificador y contenedor de ambos espacios y de los distintos grupos socio-étnicos que los integran.

  15. First Late Triassic Record of a Paleoentomofauna from South America(Malargüe Basin,Mendoza Province,Argentina)

    Institute of Scientific and Technical Information of China (English)

    Carsten BRAUCKMANN; Oscar F.GALLEGO; Norbert HAUSCHKE; Rafael G.MARTINS-NETO; Elke GROENING; Jan-M.ILGER; María B.LARA

    2010-01-01

    Late Middle Triassic to early Late Triassic insects from Argentina have been previously described from the Bermejo and Cuyana Basins where they have been recovered from the Ischichuca-Los Rastros and Potrerillos-Cacheuta Formations,respectively.The insect fauna discussed herein was collected during field studies in 1986/1987 from the Llantenes section(Norian to Rhaetian? Late Triassic),which is situated in the Malargtie Basin in southern Mendoza province.The insect remains were found in the upper part of the Llantenes section(Llantenes Formation),which is built up of two coarsening-upwards cycles reflecting a deltaic progradation of a fluvial into a lacustrine environment(lower part),succeeded by repeated progradations into a floodplaindominated environment(upper part; with finds of insects,conchostracans,fish remains,plant fragments,and drifted logs).The new finds represent the youngest Triassic insect records described from Argentina and even from South America in its entirety.There is only one contemporaneous fossil assemblage in Gondwana:in the Clarence/Moreton Basin(Aberdare Conglomerate; Late Norian)in Australia.The new Triassic insects include an impression of an isolated Mecopterida-like wing(Mendozachorista volkheimeri gen.et sp.nov.;Mendozachoristidae fam.nov.),coleopteran elytra of the Permosynidae(Ademosyne rosenfeldi sp.nov.and Ademosyne llantenesensis sp.nov.)and other isolated body fragments.This new Late Triassic entomofauna from Argentina is of considerable importance in the reconstruction of the biotic recovery of continental environments in Gondwana after the catastrophic mass extinction at the P/T boundary.

  16. Caracterización de la zona de alteración Central II, Bloque San Rafael, provincia de Mendoza

    Directory of Open Access Journals (Sweden)

    M.F. Gargiulo

    2007-09-01

    Full Text Available Se presenta el estudio petrográfico de las muestras de superficie correspondientes a la zona de alteración Central II, localizada en el Bloque San Rafael, provincia de Mendoza (34°54'56" S; 68°37'02" O. La misma está relacionada a la intrusión de un cuerpo hipabisal de composición riolítica alojado en una sucesión de rocas volcánicas y volcaniclásticas de la sección superior del Grupo Choiyoi. La zona de alteración está representada por sericitización generalizada a la que se sobreimponen brechas y venas silíceas, ocasionalmente con textura drusiforme y con bandas tapizadas por agregados diseminados de pirita y calcopirita subordinada, a las que acompaña escasa arsenopirita. Las brechas y venas silíceas conforman una faja de dirección ONO (azimut 290° - 300° e inclinación vertical, en las que se han reconocido texturas de cuarzo hidrotermal de crecimiento primario, de recristalización y de reemplazo. Entre estas texturas se destacan las crustificaciones complejas, el bandeamiento coloforme y los pseudomorfos de cuarzo según calcita en enrejado, a las que se asocia la presencia de adularia con morfologías sub-rómbica, rómbica y pseudo-acicular. Este conjunto de texturas y morfologías permite establecer que se trata de un sistema epitermal de baja sulfuración con paleozonas de ebullición ascendente.

  17. Safety assessment of biotechnology used in animal production, including genetically modified (GM) feed and GM animals - a review

    OpenAIRE

    Kleter, G.A.; Kok, E.J.

    2010-01-01

    Since the beginning of the large-scale commercial cultivation of genetically modified (GM) crops in the mid-nineties, it has continuously increased. This has occurred in particular in non-European countries from which these crops may be exported as commodities to Europe and other markets. Before genetically modified organisms (GMO) are allowed onto the market as animal feed and/or food, they have to undergo a regulatory safety assessment as required by the law in many nations, including that ...

  18. The Economic Impacts of GM Contamination Incidents on the Organic Sector

    OpenAIRE

    Hewlett, Ms Kathleen; Azeez, Ms Gundula

    2008-01-01

    This paper examines the economic impact of GM co-existence on the global organic sector to date through GM contamination of organic food and crops. A total of 15 GM contamination incidents in the organic sector are identified, occurring either from cross-pollination from GM crops being grown in the area or due to contamination in the post-harvest supply chain. The financial losses incurred by organic farmers and food companies due to GM contamination are considerable, through lost markets, lo...

  19. Developing GM super cassava for improved health and food security: future challenges in Africa

    Directory of Open Access Journals (Sweden)

    Adenle Ademola A

    2012-08-01

    Full Text Available Abstract Background There is an urgent need to solve the problem of micronutrient malnutrition that is prevalent among young children and women in Africa. Genetically modified (GM biofortified cassava has great potential to solve part of this problem, but controversy surrounding GM technology and lack of awareness, limited facilities, biased news and other factors may hinder the adoption of GM cassava in the future. Method Using semi-structured interviews in Ghana and Nigeria, this paper examines the perspectives of scientists, including the BioCassava Plus (BC+ team, on the potential adoption of GM cassava for improving health and food security in Africa. The article also examines issues around the regulatory system and transfer and acceptance of GM cassava among scientists. Results and discussion The result suggests that an overwhelming majority of scientists agree that GM biofortified cassava will benefit the health of millions in Africa, and that GM cassava conferred with disease and pest resistance will increase cassava production as it is currently plagued by cassava mosaic diseases (CMD. However, respondents are wary of long-term effects of GM cassava on the environment and lack of a regulatory framework to facilitate the adoption of GM cassava. Even though scientists expressed little or no concern about health risks of GM cassava, they were concerned that consumers may express such concerns given limited understanding of GM technology. Conclusion The article concludes with a summary of priorities for policy development with regard to adopting biofortified food products.

  20. Lista de sírfidos afidófagos y primeros registros de Pseudodoros clavatus y Eupeodes rojasi (Diptera: Syrphidae, potenciales agentes de control biológico en la provincia de Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Guillermo P. LÓPEZ GARCÍA

    2013-01-01

    Full Text Available Se presenta la primera lista de sírfidos afidófagos para la provincia de Mendoza y se reportan primeros registros de Pseudodoros clavatus Fabricius y Eu - peodes rojasi Marnef, potenciales agentes para el control biológico de áfidos plagas.

  1. El problema de los robos: de los temores de la élite a las prácticas de subsistencia de los sectores subalternos. Mendoza (Río de la Plata, 1820-1831

    Directory of Open Access Journals (Sweden)

    Molina, Eugenia

    2014-04-01

    Full Text Available This essay focuses on a specific study of thefts that occurred in the jurisdiction of Mendoza at the time of the formation of the provincial state. To do this, we will analyze judicial cases and government documents preserved in the Historical Archive of Mendoza. The aim of the study is to determine if the fears of the local elite, in the face of what they interpreted as growing post-revolutionary social conflict, were borne out by the information given in the sources; furthermore, we also aim to detect on which offenses against property they prioritized surveillance and punishment.En este trabajo nos centramos en un estudio específico de los robos ocurridos en la jurisdicción de Mendoza en el momento de conformación del estado provincial. Para ello analizaremos expedientes judiciales y documentos gubernamentales conservados en el Archivo Histórico de Mendoza. El objetivo del estudio apunta a determinar si los temores de la élite local, ante lo que ella interpretaba como una creciente conflictividad social pos revolucionaria, se correspondieron con lo planteado en las fuentes; no obstante, también buscamos detectar sobre qué atentados contra la propiedad focalizaron la vigilancia y punición.

  2. Vida y muerte de doña Melchora Lemos, empresaria vitivinícola y terciaria de la Orden de Predicadores (Mendoza, Reino de Chile, 1691-1741

    Directory of Open Access Journals (Sweden)

    Lacoste, Pablo

    2006-08-01

    Full Text Available This paper studies the life and death of doña Melchora Lemos, «pulpera», miller and wine maker in Mendoza, in Chile’s Kingdom. She was the only woman who owned a «pulperia» in the province; she built the only mill of the city; and she leaded one of better winery of Mendoza. Her life and death developed under catholic church influence. The sources of the paper are unpublished documents taken from the historical Archives in Mendoza (Argentine and Santiago (Chile.

    El artículo examina la historia de vida y muerte de doña Melchora Lemos, singular empresaria del siglo XVIII. Ella era la única mujer que poseía una pulpería; levantó el entonces único molino harinero de la ciudad; y administró la bodega más moderna de la región desde el punto de vista de la tecnología. Estos hechos se produjeron en el contexto de una intensa vida religiosa como terciaria de la orden de Santo Domingo. El estudio se ha realizado a través de fuentes originales inéditas del Archivo Nacional de Chile y el Archivo Histórico de Mendoza.

  3. Les variations récentes (1975-2000 de l’englacement dans le Massif de l’Aconcagua (Mendoza, Argentine

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    Julie Le Gall

    2008-03-01

    Full Text Available La région de Mendoza est particulièrement vulnérable au réchauffement climatique. Les glaciers du massif de l’Aconcagua ont amorcé un important retrait depuis la fin du Petit Âge de Glace. Or la disparition de ces glaciers risque d’entraîner une modification des régimes hydrologiques qui, jusqu’à présent, se caractérisaient par de hautes eaux estivales. Ce pic estival pourrait à l’avenir être atténué et remettre en cause les stratégies de gestion de la ressource en eau. Nous faisons ici le point sur les variations récentes de l’englacement et tentons de dessiner un scénario prospectif.Mendoza area is highly vulnerable to the global warming. The glaciers of the Aconcagua massif are currently shrinking, this trend of retreat began at the end of the Little Ice Age. The disappearance of glaciers may modify hydrological regimes. The discharge is currently at maximum during summer (related to glacier melt, but the peak discharge may occur during spring (related to snow melt in the next future. In this paper we synthesize the recent variations of the glaciers and propose a pattern of future variations.

  4. Resistencias al orden formalizado por la Constitución de Mendoza de 1854 en el ámbito de la campaña

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    Inés Sanjurjo de Driollet

    2004-01-01

    Full Text Available The work analyzes the effective application of the principles of the modern constitutionalism in Mendoza after it was formalized the liberal order by means of the Constitution of 1854. The investigation tries to quarrel if in the period of this constitution life (1854-1895, nevertheless the bigger complexity of the state mechanisms and the politics of strengthening the legal authority on the territory, there were spaces that escaped to this power, or practices resistant to the principles in vogue. The work has put on particular attention to the rural localities, which for the distances or small accessibility, is estimated they were less inclined to the changes and less exposed to the state control.El trabajo analiza la efectiva aplicación de los principios del moderno constitucionalismo en Mendoza luego de formalizado el orden liberal mediante la carta magna provincial de 1854. Trata de averiguar, si en el período de su vigencia (1854-1895, no obstante el proceso de complejización del aparato estatal y la política de afianzamiento de su potestad sobre el territorio, quedaron espacios que escaparon a ese poder, o se dieron prácticas resistentes a los principios en boga. Se ha puesto particular atención a las localidades de la campaña, que por las distancias o la poca accesibilidad, se estima eran poco proclives a los cambios y estaban menos expuestas al control estatal.

  5. LA PROFUNDIZACIÓN DE LA RACIONALIDAD INSTRUMENTAL COMO ESTRATEGIA DE LOS PODEROSOS FRENTE AL CAMBIO AMBIENTAL GLOBAL EN MENDOZA – ARGENTINA

    Directory of Open Access Journals (Sweden)

    Jorge Daniel Ivars

    2012-12-01

    Full Text Available En el presente artículo nos proponemos describir la racionalidad subyacente a las estrategias de adaptación al cambio ambiental global de los agentes poderosos de la vitivinicultura en Mendoza, Argentina. En términos estrictamente físicos, el Cambio Ambiental Global se presenta como un aumento de las temperaturas promedio a nivel global, las repercusiones de este cambio serán diferentes según sea la zona geográfica del planeta que se considere. En el oasis norte de la Provincia de Mendoza se espera una reducción en los caudales del Río que lo alimenta. Frente a esta situación, los actores poderosos de la vitivinicultura mendocina han optado por estrategias de adaptación tendientes a profundizar la racionalidad instrumental, característica de estos grupos, para hacer frente al cambio ambiental global: obtener aguas en mayor cantidad y calidad a través del traslado de sus explotaciones a zonas de montaña ubicadas aguas arriba del río  y búsqueda de mercados internacionales, entre otras.

  6. Spectroscopic Surface Brightness Fluctuations: Amplifying Bright Stars in Unresolved Stellar Populations

    Science.gov (United States)

    Mitzkus, M.; Dreizler, S.; Roth, M. M.

    2015-08-01

    We report on our early-stage efforts to resolve the Surface Brightness Fluctuations (SBFs) in the spectral dimension. Combining the diagnostic power of SBFs with the physical information content of spectra seems a tempting possibility to gain new insights into the bright stars in unresolved stellar populations. The new VLT integral field spectrograph MUSE is the first instrument that enables spectroscopic SBFs observationally.

  7. Observing Faint Companions Close to Bright Stars

    Science.gov (United States)

    Serabyn, Eugene

    2012-04-01

    Progress in a number of technical areas is enabling imaging and interferometric observations at both smaller angular separations from bright stars and at deeper relative contrast levels. Here we discuss recent progress in several ongoing projects at the Jet Propulsion Laboratory. First, extreme adaptive optics wavefront correction has recently enabled the use of very short (i.e., blue) wavelengths to resolve close binaries. Second, phase-based coronagraphy has recently allowed observations of faint companions to within nearly one diffraction beam width of bright stars. Finally, rotating interferometers that can observe inside the diffraction beam of single aperture telescopes are being developed to detect close-in companions and bright exozodiacal dust. This paper presents a very brief summary of the techniques involved, along with some illustrative results.

  8. Increasing the brightness of light sources

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Ling

    2006-11-16

    In this work the principle of light recycling is applied to artificial light sources in order to achieve brightness enhancement. Firstly, the feasibilities of increasing the brightness of light sources via light recycling are examined theoretically, based on the fundamental laws of thermodynamics including Kirchhoff's law on radiation, Planck's law, Lambert-Beer's law, the etendue conservation and the brightness theorem. From an experimental viewpoint, the radiation properties of three different kinds of light sources including short-arc lamps, incandescent lamps and LEDs characterized by their light-generating mechanisms are investigated. These three types of sources are used in light recycling experiments, for the purpose of 1. validating the intrinsic light recycling effect in light sources, e. g. the intrinsic light recycling effect in incandescent lamps stemming from the coiled filament structure. 2. acquiring the required parameters for establishing physical models, e.g. the emissivity/absorptivity of the short-arc lamps, the intrinsic reflectivity and the external quantum efficiency of LEDs. 3. laying the foundations for designing optics aimed at brightness enhancement according to the characteristics of the sources and applications. Based on the fundamental laws and experiments, two physical models for simulating the radiance distribution of light sources are established, one for thermal filament lamps, the other for luminescent sources, LEDs. As validation of the theoretical and experimental investigation of the light recycling effect, an optical device, the Carambola, is designed for achieving deterministic and multiple light recycling. The Carambola has the function of a concentrator. In order to achieve the maximum possible brightness enhancement with the Carambola, several combinations of sources and Carambolas are modelled in ray-tracing simulations. Sources with different light-emitting mechanisms and different radiation properties

  9. GM as a route for delivery of sustainable crop protection.

    Science.gov (United States)

    Bruce, Toby J A

    2012-01-01

    Modern agriculture, with its vast monocultures of lush fertilized crops, provides an ideal environment for adapted pests, weeds, and diseases. This vulnerability has implications for food security: when new pesticide-resistant pest biotypes evolve they can devastate crops. Even with existing crop protection measures, approximately one-third yield losses occur globally. Given the projected increase in demand for food (70% by 2050 according to the UN), sustainable ways of preventing these losses are needed. Development of resistant crop cultivars can make an important contribution. However, traditional crop breeding programmes are limited by the time taken to move resistance traits into elite crop genetic backgrounds and the limited gene pools in which to search for novel resistance. Furthermore, resistance based on single genes does not protect against the full spectrum of pests, weeds, and diseases, and is more likely to break down as pests evolve counter-resistance. Although not necessarily a panacea, GM (genetic modification) techniques greatly facilitate transfer of genes and thus provide a route to overcome these constraints. Effective resistance traits can be precisely and conveniently moved into mainstream crop cultivars. Resistance genes can be stacked to make it harder for pests to evolve counter-resistance and to provide multiple resistances to different attackers. GM-based crop protection could substantially reduce the need for farmers to apply pesticides to their crops and would make agricultural production more efficient in terms of resources used (land, energy, water). These benefits merit consideration by environmentalists willing to keep an open mind on the GM debate.

  10. The environment of Low Surface Brightness Galaxies

    OpenAIRE

    Rosenbaum, S. D.; Bomans, D. J.

    2004-01-01

    Using the Early Data Release of the Sloan Digital Sky Survey (SDSS) we investigated the clustering properties of Low Surface Brightness (LSB) galaxies in comparison to normal, High Surface Brightness (HSB) galaxies. We selected LSB galaxies and HSB galaxies with well measured redshifts from the SDSS data base and performed three-dimensional neighbour counting analysis within spheres of radii between 0.8 Mpc and 8.0 Mpc. As a second analysis method we used an N-th neighbour analysis with N var...

  11. The historical investigation of cometary brightness

    Science.gov (United States)

    Hughes, David W.

    1998-12-01

    The interpretation of the way in which the brightness of a comet varied as a function of both its heliocentric and geocentric distance was essentially started by Isaac Newton in his book Philosophiae Naturalis Principia Mathematica, published in 1687. Astronomers have argued about the form of this variability ever since, and for many years it was regarded as an important clue as to the physical nature of the cometary nucleus and its decay process. This paper reviews our understanding of the causes of cometary brightness variability between about 1680 and the 1950s.

  12. Análisis del campo de esfuerzos en una secuencia lacustre de Precordillera oriental, San Juan-Mendoza Analysis of the stress field in a lacustrine sequence of eastern Precordillera, San Juan-Mendoza

    Directory of Open Access Journals (Sweden)

    Laura P. Perucca

    2008-06-01

    Full Text Available En la quebrada del río Acequión, ubicada en el sur de la provincia de San Juan y norte de Mendoza (32º 10' S, en el centrooeste argentino, se efectuó el análisis de las fallas que afectan depósitos lacustres de edad holocena. Estas fallas se encuentran asociadas a estructuras de licuefacción y avalanchas de roca indicadoras de paleoterremotos, lo que permite extender el registro sísmico de la región hasta el Holoceno temprano. Al comparar el campo de esfuerzos regional actual (determinado por sismicidad instrumental, con el cálculo del mecanismo focal de los terremotos recientes ocurridos en la región con el campo de esfuerzos local, se observó que mientras el primero se caracteriza por la compresión, el campo local de la secuencia lacustre es extensional. Esto indicaría que aunque el esfuerzo regional actual es compresivo y de dirección NE-SO debido a la convergencia entre las placas de Nazca y Sudamérica, el antiguo lago adosado a las sierras de Pedernal y Los Pozos, está afectado por fallas normales, principalmente debido a esfuerzos locales distensivos originados por el reacomodamiento de estos depósitos durante el levantamiento de las zonas montañosas aledañas.An analysis of faults affecting Late Neogene lacustrine deposits was made in Acequión area, placed in the south of the province of San Juan. These faults are associated with liquefaction structures and rock avalanche deposits originated by paleoearthquakes, extending the earthquake records until the early Holocene in this region. By comparing the present regional stress field (determined by instrumental seismicity, with the focal mechanism analysis of recent earthquakes occurred in the region with the local stress field, it was observed that whereas the first one is characterized by compression, the local field on the lacustrine sequence is normal. The current regional stress field is compressive due to the subduction of Nazca plate under South America plate. The

  13. GM crops and foods: what do consumers want to know?

    Science.gov (United States)

    McHughen, Alan

    2013-01-01

    Agricultural biotechnology--GMOs--has a huge positive impact on farming and farmers but remains controversial among the skeptical public. Curious but anxious consumers, driven by scare stories and pseudo-science provided by anti-GMO activists, seek accurate and authoritative answers to their questions. Here, I address a sample of such queries directed to me from the public, including the ubiquitous "Is it safe?" and also discuss some of the shameful tactics used by anti-GM activists in the public debate to garner support at the cost of inciting unnecessary anxiety among the public.

  14. On algebraic spaces with an action of G_m

    OpenAIRE

    Drinfeld, Vladimir

    2013-01-01

    Let Z be an algebraic space of finite type over a field, equipped with an action of the multiplicative group $G_m$. In this situation we define and study a certain algebraic space equipped with an unramified morphism to $A^1\\times Z\\times Z$, where $A^1$ is the affine line. (If Z is affine and smooth this is just the closure of the graph of the action map $G_m\\times Z\\to Z$.) In articles joint with D.Gaitsgory we use this set-up to prove a new result in the geometric theory of automorphic for...

  15. Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke.

    Directory of Open Access Journals (Sweden)

    Sarah Caughlin

    Full Text Available The aging brain is often characterized by the presence of multiple comorbidities resulting in synergistic damaging effects in the brain as demonstrated through the interaction of Alzheimer's disease (AD and stroke. Gangliosides, a family of membrane lipids enriched in the central nervous system, may have a mechanistic role in mediating the brain's response to injury as their expression is altered in a number of disease and injury states. Matrix-Assisted Laser Desorption Ionization (MALDI Imaging Mass Spectrometry (IMS was used to study the expression of A-series ganglioside species GD1a, GM1, GM2, and GM3 to determine alteration of their expression profiles in the presence of beta-amyloid (Aβ toxicity in addition to ischemic injury. To model a stroke, rats received a unilateral striatal injection of endothelin-1 (ET-1 (stroke alone group. To model Aβ toxicity, rats received intracerebralventricular (i.c.v. injections of the toxic 25-35 fragment of the Aβ peptide (Aβ alone group. To model the combination of Aβ toxicity with stroke, rats received both the unilateral ET-1 injection and the bilateral icv injections of Aβ25-35 (combined Aβ/ET-1 group. By 3 d, a significant increase in the simple ganglioside species GM2 was observed in the ischemic brain region of rats who received a stroke (ET-1, with or without Aβ. By 21 d, GM2 levels only remained elevated in the combined Aβ/ET-1 group. GM3 levels however demonstrated a different pattern of expression. By 3 d GM3 was elevated in the ischemic brain region only in the combined Aβ/ET-1 group. By 21 d, GM3 was elevated in the ischemic brain region in both stroke alone and Aβ/ET-1 groups. Overall, results indicate that the accumulation of simple ganglioside species GM2 and GM3 may be indicative of a mechanism of interaction between AD and stroke.

  16. Soybean GmDREBL Increases Lipid Content in Seeds of Transgenic Arabidopsis

    Science.gov (United States)

    Zhang, Yu-Qin; Lu, Xiang; Zhao, Fei-Yi; Li, Qing-Tian; Niu, Su-Ling; Wei, Wei; Zhang, Wan-Ke; Ma, Biao; Chen, Shou-Yi; Zhang, Jin-Song

    2016-01-01

    A DREB-type transcription factor gene GmDREBL has been characterized for its functions in oil accumulation in seeds. The gene is specifically expressed in soybean seeds. The GmDREBL is localized in nucleus and has transcriptional activation ability. Overexpression of GmDREBL increased the fatty acid content in the seeds of transgenic Arabidopsis plants. GmDREBL can bind to the promoter region of WRI1 to activate its expression. Several other genes in the fatty acid biosynthesis pathway were also enhanced in the GmDREBL-transgenic plants. The GmDREBL can be up-regulated by GmABI3 and GmABI5. Additionally, overexpression of GmDREBL significantly promoted seed size in transgenic plants compared to that of WT plants. Expression of the DREBL is at higher level on the average in cultivated soybeans than that in wild soybeans. The promoter of the DREBL may have been subjected to selection during soybean domestication. Our results demonstrate that GmDREBL participates in the regulation of fatty acid accumulation by controlling the expression of WRI1 and its downstream genes, and manipulation of the gene may increase the oil contents in soybean plants. Our study provides novel insights into the function of DREB-type transcription factors in oil accumulation in addition to their roles in stress response. PMID:27694917

  17. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.

    Directory of Open Access Journals (Sweden)

    Wei Wei

    Full Text Available BACKGROUND: Soybean [Glycine max (L. Merr.] is one of the most important crops for oil and protein resource. Improvement of stress tolerance will be beneficial for soybean seed production. PRINCIPAL FINDINGS: Six GmPHD genes encoding Alfin1-type PHD finger protein were identified and their expressions differentially responded to drought, salt, cold and ABA treatments. The six GmPHDs were nuclear proteins and showed ability to bind the cis-element "GTGGAG". The N-terminal domain of GmPHD played a major role in DNA binding. Using a protoplast assay system, we find that GmPHD1 to GmPHD5 had transcriptional suppression activity whereas GmPHD6 did not have. In yeast assay, the GmPHD6 can form homodimer and heterodimer with the other GmPHDs except GmPHD2. The N-terminal plus the variable regions but not the PHD-finger is required for the dimerization. Transgenic Arabidopsis plants overexpressing the GmPHD2 showed salt tolerance when compared with the wild type plants. This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes. SIGNIFICANCE: These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator.

  18. Lensing Effects on the Brightness of SN Ia, When Using the Sinusoidal Potential.

    Science.gov (United States)

    Dadras, M. J.; Bartlett, D. F.; Motl, P.

    2004-05-01

    In this paper the effects of gravitational lensing of SN Ia are studied, for the case when the Newtonian potential is replaced by the sinusoidal potential (GM/r -> (GM cos[kr])/r). First we treat the point-mass case, then move on to the instance of a diffuse mass. As one might guess, with this new potential, the plot of the bending angle (α ) with respect to impact parameter (b) goes from dropping off as b-1, to having oscillations that die off as the b-1/2. This in turn will cause dramatic effects on magnification and brightness. In principle the value of the cosmological deceleration parameter (q0), can be determined by a measurement of the ratio of α to b. Wambsganss et al (1997) and Holz (1998) discussed the effects of weak gravitational lensing from large-scale structure on determining q0 within standard cosmology. Following their reasoning, we extend that work to the case of the sinusoidal potential.

  19. Brightness of synchrotron radiation from wigglers

    Science.gov (United States)

    Geloni, Gianluca; Kocharyan, Vitali; Saldin, Evgeni

    2016-01-01

    According to the literature, while calculating the brightness of synchrotron radiation from wigglers, one needs to account for the so-called 'depth-of-field' effects. In fact, the particle beam cross-section varies along the wiggler. It is usually stated that the effective photon source size increases accordingly, while the brightness is reduced. Here we claim that this is a misconception originating from an analysis of the wiggler source based on geometrical arguments, regarded as almost self-evident. According to electrodynamics, depth-of-field effects do not exist: we demonstrate this statement both theoretically and numerically, using a well-known first-principle computer code. This fact shows that under the usually accepted approximations, the description of the wiggler brightness turns out to be inconsistent even qualitatively. Therefore, there is a need for a well-defined procedure for computing the brightness from a wiggler source. We accomplish this task based on the use of a Wigner function formalism. We exemplify this formalism in simple limiting cases. We consider the problem of the calculation of the wiggler source size by means of numerical simulations alone, which play the same role of an experiment. We report a significant numerical disagreement between exact calculations and approximations currently used in the literature.

  20. Dark Matter in Low Surface Brightness Galaxies

    NARCIS (Netherlands)

    Blok, W. J. G. de; McGaugh, S. S.

    1996-01-01

    Abstract: Low Surface Brightness (LSB) galaxies form a large population of disc galaxies that extend the Hubble sequence towards extreme late-types. They are only slowly evolving, and still in an early evolutionary state. The Tully-Fisher relation and rotation curves of LSB galaxies both show that L

  1. Dark matter in low surface brightness galaxies

    NARCIS (Netherlands)

    de Blok, WJG; McGaugh, SS; Persic, M; Salucci, P

    1997-01-01

    Low Surface Brightness (LSB) galaxies form a large population of disc galaxies that extend the Hubble sequence towards extreme late-types. They are only slowly evolving, and still in an early evolutionary state. The Tully-Fisher relation and rotation curves of LSB galaxies both show that LSB galaxie

  2. Probable Bright Supernova discovered by PSST

    Science.gov (United States)

    Smith, K. W.; Wright, D.; Smartt, S. J.; Young, D. R.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-09-01

    A bright transient, which is a probable supernova, has been discovered as part of the Pan-STARRS Survey for Transients (PSST). Information on all objects discovered by the Pan-STARRS Survey for Transients is available at http://star.pst.qub.ac.uk/ps1threepi/ (see Huber et al. ATel #7153).

  3. Brightness and darkness as perceptual dimensions.

    Directory of Open Access Journals (Sweden)

    Tony Vladusich

    2007-10-01

    Full Text Available A common-sense assumption concerning visual perception states that brightness and darkness cannot coexist at a given spatial location. One corollary of this assumption is that achromatic colors, or perceived grey shades, are contained in a one-dimensional (1-D space varying from bright to dark. The results of many previous psychophysical studies suggest, by contrast, that achromatic colors are represented as points in a color space composed of two or more perceptual dimensions. The nature of these perceptual dimensions, however, presently remains unclear. Here we provide direct evidence that brightness and darkness form the dimensions of a two-dimensional (2-D achromatic color space. This color space may play a role in the representation of object surfaces viewed against natural backgrounds, which simultaneously induce both brightness and darkness signals. Our 2-D model generalizes to the chromatic dimensions of color perception, indicating that redness and greenness (blueness and yellowness also form perceptual dimensions. Collectively, these findings suggest that human color space is composed of six dimensions, rather than the conventional three.

  4. A photometric investigation of a bright Geminid

    NARCIS (Netherlands)

    Degewij, J.; Diggelen, Johannes van

    1968-01-01

    Photographic observations of meteors in the Netherlands started with a bright Geminid of photographic magnitude −8 observed on December 11, 1955, 21h39m55s by M. Alberts. From the assumed radiant and velocity we have constructed the trajectory of the bolide. The luminosity of the trail has been dete

  5. Alberta Associations for Bright Children Members' Handbook.

    Science.gov (United States)

    Alberta Association for Bright Children, Edmonton.

    This handbook is designed to provide information to parents of gifted children in Alberta, Canada. The handbook outlines the mission and objectives of the Alberta Associations for Bright Children and describes the structure of the non-profit organization. The booklet then addresses: (1) the characteristics of gifted children; (2) the rights of…

  6. ESTRATEGIAS ALIMENTARIAS Y DE SUBSISTENCIA PREHISPÁNICA EN EL CENTRO-OESTE DE MENDOZA: CONSUMO Y DESCARTE EN EL SITIO ARQUEOLÓGICO AGUA AMARGA / Food and subsistence strategies in the prehispanic Mendoza Midwest: Consumption and discard at Agua Amarga

    Directory of Open Access Journals (Sweden)

    María José Ots

    2011-12-01

    Full Text Available Se presenta el análisis de un depósito de desechos asociados a la alimentación en Agua Amarga (departamento de Tupungato, en el Centro Oeste de la provincia de Mendoza. Agua Amarga es un sitio residencial de actividades múltiples ubicado en el piedemonte del Valle de Uco, a 1000 msnm. Los fechados obtenidos sobre cerámica y restos vegetales del contexto lo ubican en el período tardío y de dominación incaica regional. El propósito del trabajo es estudiar estrategias de procesamiento, consumo y descarte de alimentos que asimismo contribuyan a la discusión sobre las estrategias de subsistencia prehispánicas en el Norte y Centro de Mendoza. Se aplican métodos y técnicas específicos para la identificación y el análisis de los restos, y se proponen hipótesis alternativas sobre dicho contexto. Los materiales recuperados, la mayoría de ellos termoalterados y muy fragmentados, incluyen macrorrestos arqueobotánicos (principalmente Zea mays y Phaseulus vulgaris, restos óseos (algunos elementos identificados como Lama sp., fragmentos de distintos recipientes cerámicos y de artefactos de molienda.  Finalmente, se discuten prácticas asociadas con la alimentación y la subsistencia, con especial referencia a la producción y consumo de maíz en el área.   Palabras clave: alimentación, subsistencia, maíz, Mendoza   Abstract We present the study of a refuse deposit associated with feeding activities in the archaeological site Agua Amarga (Tupungato department, Middle West of Mendoza province. This is a residencial site of multiple activities located in the foothill in Valle de Uco, to 1000 masl. We dated ceramics and vegetal remains that locate the context in the late period and during regional inca domination. Our goal is to study strategies of processing, consumption and discarding of foods that also contribute in the discussion on the prehispanic strategies of subsistence in the North and Center of Mendoza province. In this paper

  7. Early Callovian ingression in southwestern Gondwana. Palaeoenvironmental evolution of the carbonate ramp (Calabozo Formation) in southwestern Mendoza, Neuquen basin, Argentina

    Science.gov (United States)

    Armella, Claudia; Cabaleri, Nora G.; Cagnoni, Mariana C.; Panarello, Héctor O.

    2013-08-01

    The carbonatic sequence of the Calabozo Formation (Lower Callovian) developed in southwestern Gondwana, within the northern area of the Neuquén basin, and is widespread in thin isolated outcrops in southwestern Mendoza province, Argentina. This paper describes the facies, microfacies and geochemical-isotopic analysis carried out in five studied localities, which allowed to define the paleoenvironmental conditions of a homoclinal shallow ramp model, highly influenced by sea level fluctuations, where outer, mid and inner ramp subenvironments were identified. The outer ramp subenvironment was only recognized in the south of the depocenter and is characterized by proximal outer ramp facies with shale levels and interbedded mudstone and packstone layers. The mid ramp subenvironment is formed by low energy facies (wackestone) affected by storms (packstones, grainstones and floatstones). The inner ramp subenvironment is the most predominant and is characterized by tidal flat facies (wackestones, packstones and grainstones) over which a complex of shoals (grainstones and packstones) dissected by tidal channels (packstone, grainstones and floatstones) developed. In the north area, protected environment facies were recorded (bioturbated wackestones and packstones). The vertical distribution of facies indicates that the paleoenvironmental evolution of the Calabozo Formation results from a highstand stage in the depocenter, culminating in a supratidal environment, with stromatolitic levels interbedded with anhydrite originated under restricted water circulation conditions due to a progressive isolation of the basin. δ13C and δ18O values of the carbonates of the Calabozo Formation suggest an isotopic signature influenced by local palaeoenvironmental parameters and diagenetic overprints. The δ13C and δ18O oscillations between the carbonates of the different studied sections are related with lateral facies variations within the carbonate ramp accompanied with dissimilar

  8. Metasomatismo en ortoanfibolitas de la Faja máfica-ultramáfica del río de las tunas, Mendoza Metasomatism in orthoamphibolites from the Río de Las Tunas mafic-ultramafic belt, Mendoza

    Directory of Open Access Journals (Sweden)

    M. Florencia Gargiulo

    2012-06-01

    Full Text Available Se identificaron claras evidencias petro-mineralógicas y químicas de metasomatismo en ortoanfibolitas de la faja máficaultramáfica del Río de Las Tunas, Cordillera Frontal de Mendoza. Estas ortoanfibolitas integran el basamento metamórfico de la Cordillera Frontal y pertenecen al Complejo Guarguaráz. La peculiaridad que poseen, es el desarrollo de asociaciones de minerales calcosilicáticos vinculados a texturas que indican condiciones de desequilibrio. Los cristaloblastos de anfíbol están reemplazados en los bordes por clinopiroxeno (diópsido ferroso y los individuos de plagioclasa se encuentran casi completamente reemplazados por un agregado muy fino de granate-epidotos.l -prehnita-pumpellyita-albita, que actúa a modo de matriz de la roca. Los cristales de anfíbol y clinopiroxeno están, a su vez, parcialmente reemplazados por pumpellyita y/o clorita, mientras que la matriz se encuentra alterada débilmente por muscovita y calcita. Los cristales de granate corresponden a la serie grosularia-andradita y su composición promedio es Alm05Adr53Prp01Sps04Grs36Uv01. Cristales con mayor contenido de Cr2O3 (11,69-13,17% en peso y sutil zonalidad composicional, determinada por un núcleo más rico en el componente uvarovítico: Alm03Adr13Prp00Sps02Grs35Uv47, y borde con incremento de la proporción del componente grosulárico: Alm03Adr12Prp00Sps01Grs44Uv40, suelen estar en contacto con cristales de magnetita con hasta un 20% de componente cromítico. La zonalidad composicional presente también en los cristales de anfíbol permitió estimar valores de presión entre 2,5 y 4,2 kbar. Las asociaciones minerales junto con sus características texturales y químicas distinguen a estas rocas del resto de las ortoanfibolitas que afloran en el área de estudio y se las interpreta y clasifica como rodingitas clinopiroxénicas con granate y clinozoisita. Las condiciones de presión obtenidas, junto con el desarrollo de los minerales calcosilic

  9. Science, politics, and the GM debate in Europe.

    Science.gov (United States)

    Tencalla, Francesca

    2006-02-01

    Europe today stands at a crossroad, facing challenges but also opportunities. In its intent to make Europe a leading technology-based economy by 2010, the European Commission has identified biotechnology and genomics as fields for future growth, crucial for supporting the agricultural and food processing industry. Since first commercialization in 1996, GM crop areas have grown at double-digit rates, making this one of the most rapidly adopted technologies in agriculture. However, in contrast to other world areas and despite European Commission support, Europe has found itself 'bogged-down' in a polemic between opponents and supporters of plant biotechnology. As a result, planted areas have remained small. This stalemate is due to a lack of political leadership, especially at the Member State level, all the more surprising in light of European early development and competitive advantage with crop biotechnology. This situation proves once again that, for cutting-edge innovations, a solid science base alone is not sufficient. Acceptance or rejection of new technologies depends on interlinked political, economic, and societal factors that create a favorable or unfavorable situation at a given time. This article will look at GM crops in Europe and the role science and politics have played in the introduction of crop biotechnology. PMID:16188360

  10. Animal models of GM2 gangliosidosis: utility and limitations.

    Science.gov (United States)

    Lawson, Cheryl A; Martin, Douglas R

    2016-01-01

    GM2 gangliosidosis, a subset of lysosomal storage disorders, is caused by a deficiency of the glycohydrolase, β-N-acetylhexosaminidase, and includes the closely related Tay-Sachs and Sandhoff diseases. The enzyme deficiency prevents the normal, stepwise degradation of ganglioside, which accumulates unchecked within the cellular lysosome, particularly in neurons. As a result, individuals with GM2 gangliosidosis experience progressive neurological diseases including motor deficits, progressive weakness and hypotonia, decreased responsiveness, vision deterioration, and seizures. Mice and cats are well-established animal models for Sandhoff disease, whereas Jacob sheep are the only known laboratory animal model of Tay-Sachs disease to exhibit clinical symptoms. Since the human diseases are relatively rare, animal models are indispensable tools for further study of pathogenesis and for development of potential treatments. Though no effective treatments for gangliosidoses currently exist, animal models have been used to test promising experimental therapies. Herein, the utility and limitations of gangliosidosis animal models and how they have contributed to the development of potential new treatments are described. PMID:27499644

  11. Investigation on the magnetomechanical behavior of trilayered GM actuator

    Institute of Scientific and Technical Information of China (English)

    Heung-Shik Lee; Chongdu Cho

    2008-01-01

    In this article, it was suggested a TbFe/Co/Dy trilayered GM (Giant Magnetostrictive) film type actuator and investigated the magnetomechanical characteristics of the actuator for micro application. The trilayered films were fabricated at different thickness ratios to get an optimized structure. TbFe had positive GM properties, and cobalt, dysprosium layers made the magnetostriction property of composite film increase in low magnetic field. To fabricate the Si based microactuator with trilayered film, micromachining processes including RIE (Reactive Ion Etching) and selective DC magnetron sputtering techniques were combined. The deposited film thicknesses were measured by X-ray diffraction (XRD). As a result, the magnetization of the film on the fabricated actuator was observed to characterize the magnetic properties of the TbFe/Co/Dy film using VSM (Vibrating Sample Magnetometer). The magnetostriction of the actuator was determined by measuring the differences of curvature of the film coated silicon substrates using the optical cantilever method, and the deflections were also estimated under the external magnetic field lower than 0.5T for micro-system applications.

  12. Circadian Phase-Shifting Effects of Bright Light, Exercise, and Bright Light + Exercise

    OpenAIRE

    Youngstedt, Shawn D.; Kline, Christopher E.; Elliott, Jeffrey A; Zielinski, Mark; Devlin, Tina M.; Moore, Teresa A.

    2016-01-01

    Limited research has compared the circadian phase-shifting effects of bright light and exercise and additive effects of these stimuli. The aim of this study was to compare the phase-delaying effects of late night bright light, late night exercise, and late evening bright light followed by early morning exercise. In a within-subjects, counterbalanced design, 6 young adults completed each of three 2.5-day protocols. Participants followed a 3-h ultra-short sleep-wake cycle, involving wakefulness...

  13. Scientific development and modern wine industry: the origins and consolidation of Enology Station of Mendoza (Argentina, 1904-1920 Desarrollo científico e industria vitivinícola moderna: orígenes y consolidación de la Estación Enológica de Mendoza (Argentina, 1904- 1920

    Directory of Open Access Journals (Sweden)

    Florencia Rodríguez Vázquez

    2009-01-01

    Full Text Available In this article we propose to undertake a reconstruction of the development of the 'Estación Enológica', next to 'Escuela Nacional de Vitivinicultura', between 1904 to 1920 in Mendoza province. This study is of vital importance as we consider this place was a pioneer center in the achievement of scientific and technical studies. These were the basis for the consolidation of quality wine industry , which had many shortcomings by then, and they triggered changes in Mendoza's agroindustry. Besides, Estación Enológica became a meeting place for people who graduated from that school to share experiences and concerns. Apart from carrying out the reconstruction of the development, we will also investigate possibilities of applying these studies to vineyardsEn el presente artículo nos proponemos realizar una reconstrucción de la trayectoria de la Estación Enológica de Mendoza, anexa a la Escuela Nacional de Vitivinicultura, desde 1904 a 1920. El mismo cobra vital importancia en tanto la consideramos un centro pionero en la realización de estudios científicos y técnicos que sirvieron de base a la consolidación de una vitivinicultura de calidad -y que por entonces contaba con múltiples deficiencias- y un impulsor de cambios técnicos en la agroindustria local. A su vez, su importancia radicaría en que fue un espacio aglutinador de las experiencias e inquietudes de los enólogos graduados de la mencionada Escuela. Por último, nos referiremos a las posibilidades de recepción y divulgación de los estudios entre los vitivinicultores

  14. A Review of the World's Commercial Pipeline of GM Crops and Implications for Asynchronous Approvals and Trade

    OpenAIRE

    STEIN Alexander Jivraj; Rodriguez Cerezo, Emilio

    2009-01-01

    Commission's Joint Research Centre (JRC), Institute for Prospective Tech¬nological Studies (IPTS). The panel gathered GM technology developers (private and public), regulators and stakeholders involved in the commercialisation of GM crops worldwide. The main objective is to compile a world-wide pipeline of new GM crops that are to being commercialised in the short to medium term. This commercial pipeline of new GM crops will be analysed in view of asynchronous approval of GM cr...

  15. Comparative Analysis of Two Industries for Validating Green Manufacturing (GM) Framework: An Indian Scenario

    Science.gov (United States)

    Rehman, Minhaj Ahemad Abdul; Shrivastava, Rakesh Lakshmikumar; Shrivastava, Rashmi Rakesh

    2016-07-01

    Green Manufacturing (GM) deals with manufacturing practices that reduces or eliminates the adverse environmental impact during any of its phases. It emphasizes the use of processes that do not contaminate the environment or hurt consumers, employees, or other stakeholders. This paper presents the comparative analysis of two Indian industries representing different sectors for validating GM framework. It also highlights the road map of the companies for achieving performance improvement through GM implementation and its impact on organisational performance. The case studies helps in evaluating the companies GM implementation and overall business performance. For this, a developed diagnostic instrument in the form of questionnaire was administered amongst employees in the companies respectively and their responses were analysed. In order to have a better understanding of the impact of GM implementation, the information about overall business performance was obtained over the last 3 years. The diagnostic instrument developed here may be used by manufacturing organisations to prioritise their management efforts to assess and implement GM.

  16. La producción y función de la cerámica indígena durante la dominación incaica y la colonia en Mendoza (Argentina The production and function of indigenous ceramic during the inca domination and the colony in Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    Cristina Prieto Olavarría

    2012-07-01

    Full Text Available A partir del análisis tecnológico de las elecciones de manufactura tomadas para confeccionar la cerámica Viluco (provincia de Mendoza, Argentina, evaluamos aspectos vinculados a los contextos producción, uso y consumo de las vasijas, los que estuvieron influenciados por la dominación que ejercieron incas y espanoles sobre la población local huarpe entre los siglos XV y XVII. Los resultados obtenidos permiten sostener que la cerámica Viluco surgió y se desarrolló bajo presiones sociales, políticas, económicas y simbólicas impuestas por los incas y que, si bien su producción fue descentralizada en los contextos del valle de Mendoza, refleja las relaciones sostenidas entre esta población y los dominadores. Por otra parte, su función estuvo ligada al estatus e identidad, ya que se usó como mediador visual entre las jefaturas locales y entre éstas y los dominadores. Este desempeno se proyectó al período colonial, cuando este conjunto permitió a los grupos huarpe mantener un nexo de identidad con la anterior dominación inca, si bien existen indicadores de que la producción alfarera pudo estar bajo control espanol.Aspects related to production environments, use and consumption of Viluco ceramics from Mendoza province, Argentina, are evaluated on the basis of the technological analysis of manufacturing choices, which were influenced by the Inca and Spanish domination of the local Huarpe population between the fifteenth and sixteenth centuries AD. The results show that Viluco pottery emerged and developed under social, political, economic and symbolic pressure imposed by the Incas, and while its production was decentralized in the Mendoza valley contexts, it reflects sustained relationships among this population and the dominant power. The function of the pottery was linked to status and identity, and was used as a visual mediator among local leaders and between these and their Inca rulers. This performance was continued into the

  17. Evolución de la natación de competencia en la provincia de Mendoza, Argentina, desde 1950 hasta el año 2000 = Evolution of the swimming competition in the province of Mendoza (Argentina), from 1950 to the year 2000

    OpenAIRE

    Adrián Javier Sáez

    2013-01-01

    La investigación llevada a cabo se sustenta en un estudio exploratorio y descriptivo. El tipo de diseño de la investigación es no experimental retrospectiva porque no se manipulan las variables y se buscan datos del pasado. Fue evaluada una población de N=40 conformada por 28 nadadores, 8 entrenadores y 4 dirigentes de distintas épocas, con una encuesta para recolectar datos de los orígenes y evolución de la natación de competencia en Mendoza. Asimismo se evaluó la evolución de los records de...

  18. Historical Glacier Variations in Southern South America since the Little Ice Age: Examples from Lago Viedma (Southern Patagonia) and Mendoza (Central Andes), Argentina

    Science.gov (United States)

    Nussbaumer, S. U.; Masiokas, M.; Pitte, P.; Berthier, E.; Guerrido, C.; Luckman, B. H.; Villalba, R.

    2013-12-01

    The evaluation of historical information can give valuable insight into past glacier dynamics, especially before the onset of modern measurements. Early photographs and maps depict changes for selected glaciers in southern South America. Within this study, written documents and pictorial historical records (drawings, sketches, engravings, photographs, chronicles, topographic maps) are analysed critically, with a particular focus on two regions: Lago Viedma (El Chaltén, southern Patagonia, 49.5°S, 73.0°W) and the Río Mendoza basin (Mendoza, central Andes, 33.1°S, 69.9°W). For the Lago Viedma area, early historical data for the end of the 19th century stem from the expedition of the Chilean-Argentinean border commission. In addition, the expedition by the German Scientific Society, conducted between 1910 and 1916, and the later photographs by Alberto M. de Agostini give an excellent depiction of the glaciers. Glaciar Viedma is a calving glacier which shows distinct retreat from 1896 until the present (though with a stationary or possibly advancing glacier front between 1930/31 and 1951/52), similar to the neighbouring glaciers. On the contrary, nearby Glaciar Perito Moreno shows an exceptional behaviour: the glacier front has been advancing during the first half of the 20th century, staying in an advanced position until the present. At the beginning of the 20th century, Robert Helbling explored the Argentinean-Chilean Andes together with his friend Friedrich Reichert. In the summer of 1909/10, they started a detailed survey of the highly glacierized Juncal-Tupungato mountains (Río Mendoza basin), leading to the first accurate topographic map of the area published in 1914. Its outstanding quality allows a comparison with contemporary satellite imagery. The area received attention in 1934, when the sudden drainage of a glacier-dammed lake in the upper Río del Plomo valley caused fatalities and considerable damage to constructions and the Transandine Railway. A

  19. Tanzanian farmers' knowledge and attitudes to GM biotechnology and the potential use of GM crops to provide improved levels of food security. A Qualitative Study

    Directory of Open Access Journals (Sweden)

    Herron Caroline M

    2010-07-01

    Full Text Available Abstract Background Genetically Modified (GM crops have been championed as one possible method to improve food security and individual nutritional status in sub Saharan Africa. Understanding and acceptability of GM crop technology to farmers and consumers have not been assessed. We developed a qualitative research study involving farmers as both producers and consumers to gauge the understanding of GM crop technology, its acceptability, and identifying issues of concern. Methods Nineteen individual interviews (10 male and 9 female and five mixed gender focus group discussions with local farmers were conducted in 3 regions in Tanzania. Analysis took place concurrently with data collection. Following initial interviews, subsequent questions were adjusted based on emerging themes. Results Understanding, awareness and knowledge of GM crop technology and terminology and its potential risks and benefits was very poor in all regions. Receptivity to the potential use of GM crops was, however, high. Respondents focused on the potential benefits of GM crops rather than any potential longer term health risks. A number of factors, most significantly field trial data, would influence farmers' decisions regarding the introduction of GM crop varieties into their farming practice. Understanding of the potential improved health provision possible by changes in agricultural practice and food-related decision making, and the health benefits of a diet containing essential vitamins, minerals and micronutrients is also poor in these communities. Conclusion This study forms a basis from which further research work can be undertaken. It is important to continue to assess opinions and attitudes of farmers and consumers in sub Saharan Africa towards potential use of GM technologies whilst highlighting the importance of the relationship between agriculture, health and development. This will allow people in the region to make accurate, informed decisions about whether they

  20. GM-CSF和G-CSF的协同抗肿瘤作用

    Institute of Scientific and Technical Information of China (English)

    陈前; 窦骏

    2001-01-01

    GM-CSF抗肿瘤方面的主要作用是与免疫分子联合使用治疗肿瘤;GM-CSF基因转入肿瘤细胞和树突状细胞中分别作肿瘤疫苗和细胞疫苗发挥抗肿瘤作用;GM-CSF和G-CSF用于缓解放疗和化疗后骨髓抑制.

  1. GM-VV Part 3 – Implementation guidance for M&S projects and organizations

    OpenAIRE

    Voogd, J.

    2014-01-01

    The Generic Methodology for Verification and Validation (GM-VV) is a generic and comprehensive methodology for structuring, organizing and managing the verification and validation (V&V) of M&S assets. The GM-VV is a new recommended practice within the Simulation Interoperability Standards Organization (SISO), which is the result of a joint development effort with NATO. The GM-VV provides a technical framework to efficiently develop arguments to justify why M&S assets are acceptable or unaccep...

  2. RISK MANAGEMENT AND EXPERTISE: UK: Strategies for Precautionary Commercialization of GM Crops

    OpenAIRE

    Levidow Les; Carr Susan

    2000-01-01

    As genetically modified (GM) products approach the market stage, the UK government and agro-food industry have faced a suspicious or hostile public. Since 1998 many retail chains have undertaken to exclude any GM-derived ingredients from their own-brand lines. This commercial blockage has intensified pressures for greater precaution, even for a moratorium on cultivating GM crops. Political protest has led to strategies for precautionary commercialization. Government and industry have cooperat...

  3. GM crop technology and trade restraints: economic implications for Australia and New Zealand

    OpenAIRE

    Anderson, Kym; Jackson, Lee Ann

    2005-01-01

    How much might the potential economic benefit from enhanced farm productivity associated with crop biotechnology adoption by Australia and New Zealand (ANZ) be offset by a loss of market access abroad for crops that may contain genetically modified (GM) organisms? This paper uses the Global Trade Analysis Project (GTAP) model to estimate effects of other countries’ GM policies without and with ANZ farmers adopting GM varieties of various grains and oilseeds. The gross economic benefits to ANZ...

  4. Co-existence with GM crops: grasses, clover and fodder beet

    OpenAIRE

    Jørgensen, R. B.; Løjtnant, C.; Andersen, N.S.; Andersen, B.A.

    2007-01-01

    Co-existence with GM crops: grasses, clover and fodder beet In 2006 the global cultivation of genetically modified crops increased with 13% and reached 102 million hectares. The GM crops cultivated are mainly soybean, maize, cotton and oilseed rape, but other modified crops are appearing, e.g. in 2006 herbicide tolerant alfalfa was commercialized in US. Also in Europe, GM crop cultivation is increasing with the largest areas in Rumania and Spain followed by Portugal, France, Germany, Czec...

  5. AGRICULTURAL BIOTECHNOLOGY AND ORGANIC AGRICULTURE: NATIONAL ORGANIC STANDARDS, LABELING AND SECOND-GENERATION OF GM PRODUCTS

    OpenAIRE

    Giannakas, Konstantinos; Yiannaka, Amalia

    2003-01-01

    This paper examines the effect of the introduction of labels for products of biotechnology on the markets for GM, conventional, and organic food products. In addition, the paper analyzes the market and welfare effects of the introduction of consumer-oriented, second-generation GM products. Analytical results show that while a no-labeling regime is generally beneficial for the organic sector, when segregation costs are sufficiently high the introduction of labels for GM products can enhance th...

  6. Developing GM super cassava for improved health and food security: future challenges in Africa

    OpenAIRE

    Adenle Ademola A; Aworh Ogugua C; Akromah Richard; Parayil Govindan

    2012-01-01

    Abstract Background There is an urgent need to solve the problem of micronutrient malnutrition that is prevalent among young children and women in Africa. Genetically modified (GM) biofortified cassava has great potential to solve part of this problem, but controversy surrounding GM technology and lack of awareness, limited facilities, biased news and other factors may hinder the adoption of GM cassava in the future. Method Using semi-structured interviews in Ghana and Nigeria, this paper exa...

  7. GM2 gangliosidosis AB variant: novel mutation from India – a case report with a review

    OpenAIRE

    Sheth, Jayesh; Datar, Chaitanya; Mistri, Mehul; Bhavsar, Riddhi; Sheth, Frenny; Shah, Krati

    2016-01-01

    Background GM2 gangliosidosis-AB variants a rare autosomal recessive neurodegenerative disorder occurring due to deficiency of GM2 activator protein resulting from the mutation in GM2A gene. Only seven mutations in nine cases have been reported from different population except India. Case presentation Present case is a one year old male born to 3rd degree consanguineous Indian parents from Maharashtra. He was presented with global developmental delay, hypotonia and sensitive to hyperacusis. H...

  8. Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

    OpenAIRE

    Piccoli, Luca; Campo, Ilaria; Fregni, Chiara Silacci; Rodriguez, Blanca Maria Fernandez; Minola, Andrea; Sallusto, Federica; Luisetti, Maurizio; Corti, Davide; Lanzavecchia, Antonio

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine their specificity for the self-antigen. Individual antibodies only partially neutralize GM-CSF activity using an in vitro bioassay, depending on the experimental conditions, while, when injected in ...

  9. Analysis of the GM-CSF and GM-CSF/IL-3/IL-5 receptor common beta chain in a patient with pulmonary alveolar proteinosis

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective To investigate the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF/IL-3/IL-5 receptor common beta chain (βc receptor) in an adult patient with idiopathic pulmonary alveolar proteinosis (PAP), so as to demonstrate the possible association of the GM-CSF and βc receptor with the pathogenesis of human PAP. Methods The GM-CSF levels were measured with a commercial ELISA kit (sensitivity 5?pg/ml) and the βc receptor expression on the cell surface was detected by flow cytometry analysis. Reverse transcription-polymerase chain reaction (RT-PCR) analysis was employed to detect the expression of the GM-CSF mRNA and the βc receptor mRNA in peripheral blood mononuclear cells and alveolar macrophages. The entire coding regions of the GM-CSF cDNA and the βc receptor cDNA were sequenced by the Sanger dideoxy-mediated chain termination method to detect possible mutations. Results The patient with PAP failed to release the GM-CSF protein either from circulating mononuclear cells or from alveolar macrophages. The expression of the GM-CSF mRNA was normal after the stimulation of lipopolysaccharide, whereas a point mutation at position 382 of the GM-CSF cDNA from “T" to “C" was revealed by cDNA sequencing, which caused a change in amino acid 117 of the protein from isoleucine to threonine. The βc receptor expression on the cell surface was normal, and the βc receptor mRNA expression and the sequence of the entire coding region of the βc receptor were also normal. Conclusions The decreased GM-CSF production is associated with the pathogenesis of human PAP. A point mutation of the GM-CSF cDNA may contribute to the decreased GM-CSF production in our adult PAP patient. The mutation of the βc receptor in some of paediatric patients with PAP may not be a common problem in adult patients.

  10. Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States.

    Science.gov (United States)

    Nachamkin, I; Ung, H; Moran, A P; Yoo, D; Prendergast, M M; Nicholson, M A; Sheikh, K; Ho, T; Asbury, A K; McKhann, G M; Griffin, J W

    1999-05-01

    To determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillain-Barré syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed. To determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillan-Barre syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 enteritis-associated isolates, randomly collected in the United States, were analyzed using a cholera-toxin binding assay [corrected]. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) contained no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isolates were positive for GM1. GBS-associated serotypes were more likely to contain strains positive for GM1 than were non-GBS-associated serotypes (37.8% vs. 15.1%, P=.0116). The results suggest that humans are frequently exposed to strains exhibiting GM1-like mimicry and, while certain serotypes may be more likely to possess GM1-like epitopes, the presence of GM1-like epitopes on Campylobacter strains does not itself trigger GBS.

  11. Construction and characterization of hGM-CSF-expressing K-562 cell line

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective The whole process of vaccine preparation is time-consuming and technically challenging. Here the hGM-CSF-engineered K-562 cell line was constructed to simplify tumor vaccine preparation process. Methods The eukaryocyte expressing plasmid pcDNA3.1/GM-CSF was first constructed and its accuracy was verified through sequencing. The pcDNA3.1/GM-CSF was transfected into COS-7 cells to verify GM-CSF expression and cytokine activity using TF-1 cell line. Then the plasmid was transfected into K-562 cell line using liposome method, and was selected under G-418 and sub-cloned by limiting dilution. GM-CSF product from the monoclone GM-CSF-K-562 cell lines was quantified using ELISA method. Results We successfully constructed the hGM-CSF eukaryocyte expressing plasmid and hGM-CSF expressing K-562 cell line. Conclusion The construction of K-562/GM-CSF line will simplify the preparation of tumor vaccine, thus facilitating the application of tumor vaccination therapy in clinical application.

  12. GM crops in Ethiopia: a realistic way to increase agricultural performance?

    Science.gov (United States)

    Azadi, Hossein; Talsma, Nanda; Ho, Peter; Zarafshani, Kiumars

    2011-01-01

    Much has been published on the application of genetically modified (GM) crops in Africa, but agricultural performance has hardly been addressed. This paper discusses the main consequences of GM crops on agricultural performance in Ethiopia. Three main criteria of performance - productivity, equitability and sustainability - are evaluated in the context of the Ethiopian agricultural sector. We conclude that the application of GM crops can improve the agricultural productivity and sustainability, whereas equitability cannot be stimulated and might even exacerbate the gap between socioeconomic classes. Before introducing GM crops to Ethiopian agriculture, regulatory issues should be addressed, public research should be fostered, and more ex ante values and socioeconomic studies should be included.

  13. Construction and characterization of hGM-CSF-expressing K-562 cell line

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective The whole process of vaccine preparation is time-consuming and technically challenging. Here the hGM-CSF-engineered K-562 cell line was constructed to simplify tumor vaccine preparation process. Methods The eukaryocyte expressing plasmid pcDNA3.1/GM-CSF was first constructed and its accuracy was verified through sequencing. The pcDNA3.1/GM-CSF was transfected into COS-7 cells to verify GM-CSF expression and cytokine activity using TF-1 cell line. Then the plasmid was transfected into K-562 cell li...

  14. Necesidad de transparencia y legalidad en la gestión y uso de las aguas subterráneas (El reciente caso de la Provincia de Mendoza

    Directory of Open Access Journals (Sweden)

    María Valentina Erice

    2013-12-01

    Full Text Available En Mendoza las aguas subterráneas son un recurso natural indispensable para la subsistencia y de gran importancia para el desarrollo provincial, ya que tienen un valor no solo económico y estratégico, sino también social y ambiental. La prevención de la sobreexplotación de los acuíferos y de la contaminación de estas aguas constituye una de las preocupaciones más serias a la que se enfrentan los encargados de gestionar su uso eficiente. Para ello resulta necesario aplicar políticas de ahorro y conservación, contar con un moderno Derecho de aguas preciso, claro, coherente y conservacionista, encaminado a dar soluciones eficaces a los problemas que hoy se nos presentan y que la gestión se realice con rectitud, transparencia y respetando la Constitución y la leyes.

  15. Conflictos sociales en Mendoza entre dos crisis, 1890-1916: Una larga lucha de los trabajadores por la conquista de sus derechos laborales

    Directory of Open Access Journals (Sweden)

    Rodolfo Richard-Jorba

    2010-06-01

    Full Text Available Este artículo contribuye a la reconstrucción de la historia del mundo de los trabajadores en Mendoza. Las fuentes revisadas y la sistematización de información dispersa han permitido profundizar en los conocimientos hasta ahora generados, sacando a luz una parte significativa del desarrollo capitalista centrado en la agroindustria vitivinícola. Las fuentes principales para seguir los conflictos han sido los diarios mendocinos, por lo que nuestro abordaje constituye una aproximación que esperamos poder ampliar en el futuro. En este artículo presentamos los conflictos sociales en el contexto de períodos de crisis y de auge económico. Comenzamos por la crisis de 1890 y concluimos con la crisis provocada por la Primera Guerra Mundial y los cambios políticos que sobrevendrían a partir de 1916-1918

  16. Justicia de proximidad y gobierno político-militar en la frontera. Equipamiento institucional del Valle de Uco (Mendoza durante el proceso revolucionario (1810-1820

    Directory of Open Access Journals (Sweden)

    Eugenia Molina

    2014-12-01

    Full Text Available El trabajo reconstruye el proceso de equipamiento institucional de la campaña sur de Mendoza durante el proceso revolucionario. Focaliza la atención en la trama de funcionarios designados para la villa de San Carlos y el Valle de Uco, con el objetivo de  mostrar las articulaciones entre justicia de proximidad, gobierno político-militar y construcción de la legitimidad. La hipótesis es que las propias características de un espacio de frontera se complejizaron en el contexto de guerra, atravesaron la territorialización de este ámbito de la jurisdicción mendocina al hacer que la solución de la cuestión de la distancia tuviera un rol clave en las estrategias para gobernarlo.

  17. Diagnosing Lysosomal Storage Disorders: The GM2 Gangliosidoses.

    Science.gov (United States)

    Hall, Patricia; Minnich, Sara; Teigen, Claire; Raymond, Kimiyo

    2014-01-01

    The GM2 gangliosidoses are a group of autosomal recessive lysosomal storage disorders caused by defective β-hexosaminidase. There are three clinical conditions in this group: Tay-Sachs disease (TSD), Sandhoff disease (SD), and hexosaminidase activator deficiency. The three conditions are clinically indistinguishable. TSD and SD have been identified with infantile, juvenile, and adult onset forms. The activator deficiency is only known to present with infantile onset. Diagnosis of TSD and SD is based on decreased hexosaminidase activity and a change in the percentage of activity between isoforms. There are no biochemical tests currently available for activator deficiency. This unit provides a detailed procedure for identifying TSD and SD in affected individuals and carriers from leukocyte samples, the most robust sample type available. PMID:25271840

  18. The bright optical flash from GRB 060117

    CERN Document Server

    Jel'inek, M; Kubánek, P; Hudec, R; Nekola, M; Grygar, J; Castro-Tirado, A J; Gorosabel, J; Hrabovsk'y, M; Mandat, D; Nosek, D; Palatka, M; Pandey, S B; Pech, M; Schovanek, P; De Postigo, A U; Vítek, S; Jel\\'inek, Martin; Prouza, Michael; Kub\\'anek, Petr; Hudec, Ren\\'e; Nekola, Martin; R}\\'idk\\'y, Jan {; Grygar, Ji{r}\\'i; Castro-Tirado, Alberto J.; Gorosabel, Javier; Hrabovsk\\'y, Miroslav; Mand\\'at, Du{s}an; Nosek, Dalibor; Palatka, Miroslav; Pandey, Shashi B.; Pech, Miroslav; Schov\\'anek, Petr; S}m\\'ida, Radom\\'ir {; Postigo, Antonio de Ugarte; V\\'itek, Stanislav

    2006-01-01

    We present a discovery and observation of an extraordinarily bright prompt optical emission of the GRB 060117 obtained by a wide-field camera atop the robotic telescope FRAM of the Pierre Auger Observatory from 2 to 10 minutes after the GRB. We found rapid average temporal flux decay of alpha = -1.7 +- 0.1 and a peak brightness R = 10.1 mag. Later observations by other instruments set a strong limit on the optical and radio transient fluxes, unveiling an unexpectedly rapid further decay. We present an interpretation featuring a relatively steep electron-distribution parameter p ~ 3.0 and providing a straightforward solution for the overall fast decay of this optical transient as a transition between reverse and forward shock.

  19. Quantum Bright Soliton in a Disorder Potential

    Science.gov (United States)

    Sacha, K.; Delande, D.; Zakrzewski, J.

    2009-11-01

    At very low temperature, a quasi-one-dimensional ensemble of atoms with attractive interactions tend to form a bright soliton. When exposed to a sufficiently weak external potential, the shape of the soliton is not modified, but its external motion is affected. We develop in detail the Bogoliubov approach for the problem, treating, in a non-perturbative way, the motion of the center of mass of the soliton. Quantization of this motion allows us to discuss its long time properties. In particular, in the presence of a disordered potential, the quantum motion of the center of mass of a bright soliton may exhibit Anderson localization, on a localization length which may be much larger than the soliton size and could be observed experimentally.

  20. EDIBLE VACCINES FROM GM CROPS: CURRENT STATUS AND FUTURE SCOPE

    Directory of Open Access Journals (Sweden)

    Doshi V

    2013-06-01

    Full Text Available The idea of an edible vaccine is coming closer to reality as scientists have found a way to incorporate the protein gene with some antigen in some plants. The major hurdles in the path of an emerging vaccine technology are being overcome. In this context, genetically modified (GM plants are being investigated for the production of vaccines, antibodies and therapeutic proteins. The development of GM crops to produce drugs and vaccines has received considerable investment and is relatively well advanced. The myth surrounding edible vaccines and 'food as pill' is the difficulty to control their intake and distribution, particularly in developing countries where education levels and literacy may be low. However, this concept suffers from the fact that the potency of this class of vaccines and drugs remains unmasked to the majority of the population, which has to be publicized and campaigned in a scientific manner, to make it realistic and useful for the common man. Creating edible vaccines involves introduction of selected desired genes into plants and then inducing these altered plants to manufacture the encoded proteins. This process is known as "transformation," and the altered plants are called "transgenic plants." Like conventional subunit vaccines, edible vaccines are composed of antigenic proteins and are devoid of pathogenic genes. Thus, they have no way of establishing infection, assuring its safety, especially in immuno-compromised patients. Conventional subunit vaccines are expensive and technology-intensive, need purification, require refrigeration and produce poor mucosal response. In contrast, edible vaccines would enhance compliance, especially in children and because of oral administration, would eliminate the need for trained medical personnel. Their production is highly efficient and can be easily scaled up. If the technology is properly nurtured and given the right direction, it may usher into a new era where we will be asked to

  1. Ethical arguments relevant to the use of GM crops.

    Science.gov (United States)

    Weale, Albert

    2010-11-30

    The Nuffield Council on Bioethics (NCOB) has published two reports (1999 and 2004) on the social and ethical issues involved in the use of genetically modified crops. This presentation summarises their core ethical arguments. Five sets of ethical concerns have been raised about GM crops: potential harm to human health; potential damage to the environment; negative impact on traditional farming practice; excessive corporate dominance; and the 'unnaturalness' of the technology. The NCOB examined these claims in the light of the principle of general human welfare, the maintenance of human rights and the principle of justice. It concluded in relation to the issue of 'unnaturalness' that GM modification did not differ to such an extent from conventional breeding that it is in itself morally objectionable. In making an assessment of possible costs, benefits and risks, it was necessary to proceed on a case-by-case basis. However, the potential to bring about significant benefits in developing countries (improved nutrition, enhanced pest resistance, increased yields and new products) meant that there was an ethical obligation to explore these potential benefits responsibly, to contribute to the reduction of poverty, and improve food security and profitable agriculture in developing countries. NCOB held that these conclusions were consistent with any practical precautionary approach. In particular, in applying a precautionary approach the risks associated with the status quo need to be considered, as well as any risks inherent in the technology. These ethical requirements have implications for the governance of the technology, in particular mechanisms for enabling small-scale farmers to express their preferences for traits selected by plant breeders and mechanisms for the diffusion of risk-based evaluations.

  2. Biochemical characterization of the GM2 gangliosidosis B1 variant

    Directory of Open Access Journals (Sweden)

    J.C. Tutor

    2004-06-01

    Full Text Available The deficiency of the A isoenzyme of ß-hexosaminidase (Hex produced by different mutations of the gene that codes for the alpha subunit (Tay-Sachs disease has two variants with enzymological differences: the B variant consists of the absence of Hex A isoenzyme and the B1 variant produces an inactive Hex A isoenzyme for the hydrolysis of the GM2 ganglioside and synthetic substrates with negative charge. In contrast to the early childhood form of the B variant, the B1 variant appears at a later clinical stage (3 to 7 years of age with neurodegenerative symptoms leading to the death of the patient in the second decade of life. The most frequent mutation responsible for the GM2 gangliosidosis B1 variant is R178H, which has a widespread geographic and ethnic distribution. The highest incidence has been described in Portugal, which has been suggested as the point of origin of this mutation. Biochemical characterization of this lysosomal disease is carried out using negatively charged synthetic alpha subunit-specific sulfated substrates, since Hex A isoenzyme heat-inactivation assays are not applicable. However, the determination of the apparent activation energy of Hex using the neutral substrate 3,3'-dichlorophenolsulfonphthaleinyl N-acetyl-ß-D-glucosaminide, may offer a valid alternative. The presence of an alpha subunit in the alphaß heterodimer Hex A means that its activation energy (41.8 kJ/mol is significantly lower than that of the ßß homodimer Hex B (75.1 kJ/mol; however, as mutation inactivates the alpha subunit, the Hex A of the B1 variant presents an activation energy that is similar to that of the Hex B isoenzyme.

  3. Ethical arguments relevant to the use of GM crops.

    Science.gov (United States)

    Weale, Albert

    2010-11-30

    The Nuffield Council on Bioethics (NCOB) has published two reports (1999 and 2004) on the social and ethical issues involved in the use of genetically modified crops. This presentation summarises their core ethical arguments. Five sets of ethical concerns have been raised about GM crops: potential harm to human health; potential damage to the environment; negative impact on traditional farming practice; excessive corporate dominance; and the 'unnaturalness' of the technology. The NCOB examined these claims in the light of the principle of general human welfare, the maintenance of human rights and the principle of justice. It concluded in relation to the issue of 'unnaturalness' that GM modification did not differ to such an extent from conventional breeding that it is in itself morally objectionable. In making an assessment of possible costs, benefits and risks, it was necessary to proceed on a case-by-case basis. However, the potential to bring about significant benefits in developing countries (improved nutrition, enhanced pest resistance, increased yields and new products) meant that there was an ethical obligation to explore these potential benefits responsibly, to contribute to the reduction of poverty, and improve food security and profitable agriculture in developing countries. NCOB held that these conclusions were consistent with any practical precautionary approach. In particular, in applying a precautionary approach the risks associated with the status quo need to be considered, as well as any risks inherent in the technology. These ethical requirements have implications for the governance of the technology, in particular mechanisms for enabling small-scale farmers to express their preferences for traits selected by plant breeders and mechanisms for the diffusion of risk-based evaluations. PMID:20850572

  4. Modular Zero Energy. BrightBuilt Home

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, Robb [Steven Winter Associates, Inc., Norwalk, CT (United States); Butterfield, Karla [Steven Winter Associates, Inc., Norwalk, CT (United States)

    2016-03-01

    With funding from the Building America Program, part of the U.S. Department of Energy Building Technologies Office, the Consortium for Advanced Residential Buildings (CARB) worked with BrightBuilt Home (BBH) to evaluate and optimize building systems. CARB’s work focused on a home built by Black Bros. Builders in Lincolnville, Maine (International Energy Conservation Code Climate Zone 6). As with most BBH projects to date, modular boxes were built by Keiser Homes in Oxford, Maine.

  5. Surface Brightness Fluctuations as Stellar Population Indicators

    OpenAIRE

    Blakeslee, John P

    2009-01-01

    Surface Brightness Fluctuations (SBF) can provide useful information about the unresolved stellar content of early-type galaxies and spiral bulges. The absolute SBF magnitude Mbar in a given passband depends on the properties of the stellar population and can be predicted by population synthesis models. SBF measurements in different bandpasses are sensitive to different evolutionary stages within the galaxy stellar population. Near-IR SBF magnitudes are sensitive to the evolution of stars wit...

  6. Bright Solitary Waves in Malignant Gliomas

    OpenAIRE

    Pérez-García, Víctor M.; Calvo, Gabriel F.; Belmonte-Beitia, Juan; Diego, D.; Pérez-Romasanta, Luis

    2011-01-01

    We put forward a nonlinear wave model describing the fundamental physio-pathologic features of an aggressive type of brain tumors: glioblastomas. Our model accounts for the invasion of normal tissue by a proliferating and propagating rim of active glioma cancer cells in the tumor boundary and the subsequent formation of a necrotic core. By resorting to numerical simulations, phase space analysis and exact solutions, we prove that bright solitary tumor waves develop in such systems.

  7. Extreme Ultraviolet Explorer Bright Source List

    Science.gov (United States)

    Malina, Roger F.; Marshall, Herman L.; Antia, Behram; Christian, Carol A.; Dobson, Carl A.; Finley, David S.; Fruscione, Antonella; Girouard, Forrest R.; Hawkins, Isabel; Jelinsky, Patrick

    1994-01-01

    Initial results from the analysis of the Extreme Ultraviolet Explorer (EUVE) all-sky survey (58-740 A) and deep survey (67-364 A) are presented through the EUVE Bright Source List (BSL). The BSL contains 356 confirmed extreme ultraviolet (EUV) point sources with supporting information, including positions, observed EUV count rates, and the identification of possible optical counterparts. One-hundred twenty-six sources have been detected longward of 200 A.

  8. Morfometría de la escarpa de falla histórica identificada al norte del cerro La Cal, zona de falla La Cal, Mendoza

    Directory of Open Access Journals (Sweden)

    F. Mingorance

    2006-12-01

    Full Text Available Investigación morfométrica y paleosísmica histórica fue llevada a cabo en el Norte de Mendoza con el objeto de caracterizar y cuantificar a las evidencias geomorfológicas de ruptura superficial histórica identificadas en el sector septentrional de la zona de falla La Cal. Integración e interpretación de datos e información científica multidisciplinaria, sugieren fuertemente que la ruptura superficial histórica identificada estuvo asociada al terremoto destructivo de Mendoza ocurrido en 1861. La deformación superficial histórica ocurrió casi en su totalidad a lo largo de una escarpa prehistórica previa, mediante una combinación de fallamiento de corrimiento y plegamiento cercano a la superficie. Dos elementos de pendiente históricos de bajo relieve fueron reconocidos en la escarpa compuesta Villavicencio Sur, los cuales se diferencian de la típica secuencia de formas desarrollada en escarpas de falla normal históricas. El "remanente de cara libre", el elemento de pendiente superior, y la "pendiente de colapso", el elemento inferior, son controlados por la fricción interna y por la gravedad y la fricción de deslizamiento del material aluvial, respectivamente. La metodología paleosísmica histórica discutida en este trabajo, parece ser particularmente útil en el período de tiempo que cubre la mayor parte del registro histórico de terremotos destructivos en Argentina, los pasados 350 años, lapso en el cual la mayoría de los métodos de datación absoluta no son muy efectivos.

  9. Mendoza, Argentina. El terremoto de 1861 como disparador del cambio de representación social de la identidad de una ciudad al pie de los Andes

    Directory of Open Access Journals (Sweden)

    Jorge Ricardo Ponte

    2007-12-01

    Full Text Available The definition of a town´s identity is a contemporary problematic. The process of economic globalization, far from devastating with the regional or national particularities seems to have exacerbated them. For that reason, to look for the bases of the national or regional identity in the present forces to be dig in our own history to try to find out the real or mythical origins of the same one. But the identity is not an easy or univocal concept or of an immediate apprehension. It was neither in the past nor in the present. For that reason, this article aims to introduce the problematic of the identity form the theory of the social representations and as a case applied to the City of Mendoza, Argentina.//La definición de la identidad de los pueblos es una problemática de absoluta vigencia contemporánea. El proceso de globalización económica vigente, lejos de arrasar con las particularidades regionales o nacionales parece que, en cambio, las ha exacerbado.Por ello, buscar las bases de la identidad nacional o regional en el presente, obliga a remitirse a la propia historia para tratar de escudriñar los orígenes reales o míticos de la misma. Pero la identidad no es un concepto unívoco o de fácil e inmediata aprehensión, ni el presente, ni el pasado. Por ello, este artículo apunta a presentar la problemática de la identidad vista desde la teoría de las representaciones sociales y como caso aplicado a la Ciudad de Mendoza, Argentina.

  10. On the origin of facular brightness

    CERN Document Server

    Kostik, R

    2016-01-01

    This paper studies the dependence of the CaIIH line core brightness on the strength and inclination of photospheric magnetic field, and on the parameters of convective and wave motions in a facular region at the solar disc center. We use three simultaneous datasets obtained at the German Vacuum Tower Telescope (Observatorio del Teide, Tenerife): (1) spectra of BaII 4554 A line registered with the instrument TESOS to measure the variations of intensity and velocity through the photosphere up to the temperature minimum; (2) spectropolarimetric data in FeI 1.56 $\\mu$m lines (registered with the instrument TIP II) to measure photospheric magnetic fields; (3) filtergrams in CaIIH that give information about brightness fluctuations in the chromosphere. The results show that the CaIIH brightness in the facula strongly depends on the power of waves with periods in the 5-min range, that propagate upwards, and also on the phase shift between velocity oscillations at the bottom photosphere and around the temperature min...

  11. The Bright SHARC Survey The Cluster Catalog

    CERN Document Server

    Romer, A K; Holden, B P; Ulmer, M P; Pildis, R A; Merrelli, A J; Adami, C; Burke, D J; Collins, C A; Metevier, A J; Kron, Richard G; Commons, K

    1999-01-01

    We present the Bright SHARC (Serendipitous High-Redshift Archival ROSAT Cluster) Survey, which is an objective search for serendipitously detected extended X-ray sources in 460 deep ROSAT PSPC pointings. The Bright SHARC Survey covers an area of 178.6 sq.deg and has yielded 374 extended sources. We discuss the X-ray data reduction, the candidate selection and present results from our on-going optical follow-up campaign. The optical follow-up concentrates on the brightest 94 of the 374 extended sources and is now 97% complete. We have identified thirty-seven clusters of galaxies, for which we present redshifts and luminosities. The clusters span a redshift range of 0.0696Bright SHARC clusters have not been listed in any previously ...

  12. Search for bright stars with infrared excess

    International Nuclear Information System (INIS)

    Bright stars, stars with visual magnitude smaller than 6.5, can be studied using small telescope. In general, if stars are assumed as black body radiator, then the color in infrared (IR) region is usually equal to zero. Infrared data from IRAS observations at 12 and 25μm (micron) with good flux quality are used to search for bright stars (from Bright Stars Catalogues) with infrared excess. In magnitude scale, stars with IR excess is defined as stars with IR color m12−m25>0; where m12−m25 = −2.5log(F12/F25)+1.56, where F12 and F25 are flux density in Jansky at 12 and 25μm, respectively. Stars with similar spectral type are expected to have similar color. The existence of infrared excess in the same spectral type indicates the existence of circum-stellar dust, the origin of which is probably due to the remnant of pre main-sequence evolution during star formation or post AGB evolution or due to physical process such as the rotation of those stars

  13. LA Palma Night-Sky Brightness

    CERN Document Server

    Benn, C R; Benn, Chris R.; Ellison, Sara L.

    1998-01-01

    The brightness of the moonless night sky above La Palma was measured on 427 CCD images taken with the Isaac Newton and Jacobus Kapteyn Telescopes on 63 nights during 1987 - 1996. The median sky brightness at high elevation, high galactic latitude and high ecliptic latitude, at sunspot minimum, is B = 22.7, V = 21.9, R = 21.0, similar to that at other dark sites. The main contributions to sky brightness are airglow and zodiacal light. The sky is brighter at low ecliptic latitude (by 0.4 mag); at solar maximum (by 0.4 mag); and at high airmass (0.25 mag brighter at airmass 1.5). Light pollution (line + continuum) contributes < 0.03 mag in U, approximately 0.02 mag in B, approximately 0.10 mag in V, approximately and 0.10 mag in R at the zenith. This paper is a summary of results which are presented in full elsewhere (Benn & Ellison 1998, La Palma Technical Note 115).

  14. Functional analysis of water stress-responsive soybean GmNAC003 and GmNAC004 transcription factors in lateral root development in arabidopsis.

    Directory of Open Access Journals (Sweden)

    Truyen N Quach

    Full Text Available In Arabidopsis, NAC (NAM, ATAF and CUC transcription factors have been found to promote lateral root number through the auxin signaling pathway. In the present study, the role of water stress-inducible soybean GmNAC003 and GmNAC004 genes in the enhancement of lateral root development under water deficit conditions was investigated. Both genes were highly expressed in roots, leaves and flowers of soybean and were strongly induced by water stress and moderately induced by a treatment with abscisic acid (ABA. They showed a slight response to treatment with 2,4-dichlorophenoxyacetic acid (2,4-D. The transgenic Arabidopsis plants overexpressing GmNAC004 showed an increase in lateral root number and length under non-stress conditions and maintained higher lateral root number and length under mild water stress conditions compared to the wild-type (WT, while the transgenic plants overexpressing GmNAC003 did not show any response. However, LR development of GmNAC004 transgenic Arabidopsis plants was not enhanced in the water-stressed compared to the well-watered treatment. In the treatment with ABA, LR density of the GmNAC004 transgenic Arabidopsis was less suppressed than that of the WT, suggesting that GmNAC004 counteracts ABA-induced inhibition of lateral root development. In the treatment with 2,4-D, lateral root density was enhanced in both GmNAC004 transgenic Arabidopsis and WT plants but the promotion was higher in the transgenic plants. Conversely, in the treatment with naphthylphthalamic acid (NPA, lateral root density was inhibited and there was no difference in the phenotype of the GmNAC004 transgenic Arabidopsis and WT plants, indicating that auxin is required for the action of GmNAC004. Transcript analysis for a number of known auxin and ABA related genes showed that GmNAC004's role may suppress ABA signaling but promote auxin signaling to increase lateral root development in the Arabidopsis heterologous system.

  15. Don Juan de Palafox y Mendoza, promotor del libre acceso a la información en el siglo XVII novo-hispano Don Juan de Palafox y Mendoza promoter of free access to information in the eighteenth century in New Spain

    Directory of Open Access Journals (Sweden)

    Rosa María Fernández de Zamora

    2011-08-01

    Full Text Available Don Juan de Palafox y Mendoza, arzobispo y virrey de la Nueva España y obispo de Puebla en el siglo XVII, ha sido motivo de numerosos estudios, pero lo que se desea resaltar en este escrito es su labor como fundador de la primera biblioteca pública de México y del continente americano, misma que hoy conocemos como Biblioteca Palafoxiana, y como promotor del libre acceso a la información. En el siglo XVIII, el obispo de Puebla, Francisco Fabián y Fuero, seguidor de las ideas de Palafox, enriqueció y embelleció la biblioteca y continuó con el espíritu de apertura propuesto por el fundador. También se menciona el reconocimiento que el ilustre jesuita Clavijero hizo de las obras de Palafox.Don Juan de Palafox y Mendoza, Viceroy and Archbishop of New Spain, and Bishop of Puebla in the XVII century, has been studied by many specialists. However, the purpose of this paper is to highlight his role as founder of the first public library in Mexico and in the American Continent and promoter of free acces to information. In the XVIII Century Francisco Fabián y Fuero, Bishop of Puebla, enriched and embellished the Palafoxiana library and continued the policies of its founder. Attention is also drawn to the recognition that the renowned Jesuit Clavijero made of the work of Palafox.

  16. Comparative Proteomic Analysis of Two Varieties of Genetically Modified (GM) Embrapa 5.1 Common Bean (Phaseolus vulgaris L.) and Their Non-GM Counterparts.

    Science.gov (United States)

    Balsamo, Geisi M; Valentim-Neto, Pedro A; Mello, Carla S; Arisi, Ana C M

    2015-12-01

    The genetically modified (GM) common bean event Embrapa 5.1 was commercially approved in Brazil in 2011; it is resistant to golden mosaic virus infection. In the present work grain proteome profiles of two Embrapa 5.1 common bean varieties, Pérola and Pontal, and their non-GM counterparts were compared by two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (MS). Analyses detected 23 spots differentially accumulated between GM Pérola and non-GM Pérola and 21 spots between GM Pontal and non-GM Pontal, although they were not the same proteins in Pérola and Pontal varieties, indicating that the variability observed may not be due to the genetic transformation. Among them, eight proteins were identified in Pérola varieties, and four proteins were identified in Pontal. Moreover, we applied principal component analysis (PCA) on 2-DE data, and variation between varieties was explained in the first two principal components. This work provides a first 2-DE-MS/MS-based analysis of Embrapa 5.1 common bean grains.

  17. Geología de la región del Cerro Guanaquero, Río Diamante, Mendoza

    Directory of Open Access Journals (Sweden)

    Federico Fuentes

    2008-03-01

    Full Text Available El estudio realizado presenta nuevos datos sobre un sector poco conocido de la Cordillera Principal de Mendoza, en la alta cuenca del río Diamante en las adyacencias del cerro Guanaquero, y los primeros datos geocronológicos de sus rocas volcánicas. Las unidades geológicas presentes en el área se dividen en cuatro grupos principales: secuencias sedimentarias mesozoicas marinas y continentales intensamente plegadas y falladas; intrusivos y volcanitas intermedias de edad neógena; rocas volcánicas pliocenas a recientes de composición intermedia a básica, y depósitos cuaternarios inconsolidados. El cerro Guanaquero, un estratovolcán pliocuaternario intensamente erosionado por glaciares pleistocenos, con sus 4.841 metros es el rasgo orográfico más prominente. Está constituido esencialmente por andesitas grises porfíricas, piroxénicas a biotíticas. Intercaladas con las coladas andesíticas se presentan depósitos piroclásticos, aglomerados volcánicos, ignimbritas y basaltos. La datación de una andesita por el método K-Ar en roca total arrojó una edad de 1,4 ± 0,1 Ma. La deformación ándica comenzó en forma de una faja plegada y corrida de piel fina, con pliegues por despegue en el sector occidental y por propagación de falla en el oriental. La compresión al oeste de los 69º47´O terminó por invertir la fallas normales del rift mesozoico. A lo largo de este meridiano se encuentra la falla más importante de la región, la que se ha correlacionado con la falla Malargüe, bien desarrollada en latitudes más australes. Esta falla limita la faja plegada y corrida del Aconcagua, de naturaleza epidérmica, y la faja plegada y corrida de Malargüe, controlada por la inversión tectónica del basamento. El volcanismo fue muy intenso en el Plioceno y el Cuaternario, correspondiendo a un período de empinamiento de la placa oceánica subducida, en el que la región ha sido levantada pasivamente. La alta resistencia a la erosión de

  18. Effect of the Information on the Intention of GM Food Consumption

    OpenAIRE

    Martinez-Poveda, Africa; Molla-Bauza, Margarita Brugarolas; Martinez, Laura Martinez-Carrasco; Gomis, Francisco Jose Del Campo

    2005-01-01

    This work is focused on the study of consumption acceptance towards GM foods, analysing the level of knowledge and perceptions about them. Conjoint Analyses will be used to determine the importance of different attributes on purchase intention and GM food consumption intention will be measured as well as the effect of information on consumption intention.

  19. Biotech/GM crops in horticulture: plum cv. HoneySweet resistant to plum pox virus

    Science.gov (United States)

    Commercialization of Biotech crops started in 1995. By 2011, genetically modified (GM) crops were grown world-wide on 160 million ha. Only 114.507 ha of GM crops were grown in Europe, of that, 114.490 ha were Bt maize and 17 ha were potato for industrial starch production. Currently, developing c...

  20. GM crops in Ethiopia : a realistic way to increase agricultural performance?

    NARCIS (Netherlands)

    Azadi, Hossein; Taisma, Nanda; Ho, Peter; Zarafshani, Kiumars

    2011-01-01

    Much has been published on the application of genetically modified (GM) crops in Africa, but agricultural performance has hardly been addressed. This paper discusses the main consequences of GM crops on agricultural performance in Ethiopia. Three main criteria of performance productivity, equitabili

  1. RNAi-based GM plants: food for thought for risk assessors.

    Science.gov (United States)

    Ramon, Matthew; Devos, Yann; Lanzoni, Anna; Liu, Yi; Gomes, Ana; Gennaro, Andrea; Waigmann, Elisabeth

    2014-12-01

    RNA interference (RNAi) is an emerging technology that offers new opportunities for the generation of new traits in genetically modified (GM) plants. Potential risks associated with RNAi-based GM plants and issues specific to their risk assessment were discussed during an international scientific workshop (June 2014) organized by the European Food Safety Authority (EFSA). Selected key outcomes of the workshop are reported here.

  2. Safety assessment of GM plants: An updated review of the scientific literature.

    Science.gov (United States)

    Domingo, José L

    2016-09-01

    In a wide revision of the literature conducted in 2000, I noted that the information in scientific journals on the safety of genetically modified (GM) foods in general, and GM plants in particular, was scarce. Of course, it was not sufficient to guarantee that the consumption of these products should not mean risks for the health of the consumers. Because of the scientific interest in GM organisms (GMOs), as well as the great concern that the consumption of GM foods/plants has raised in a number of countries, I conducted two subsequent revisions (2007 and 2011) on the adverse/toxic effects of GM plants. In the present review, I have updated the information on the potential adverse health effects of GM plants consumed as food and/or feed. With only a few exceptions, the reported studies in the last six years show rather similar conclusions; that is to say, the assessed GM soybeans, rice, corn/maize and wheat would be as safe as the parental species of these plants. However, in spite of the notable increase in the available information, studies on the long-term health effects of GM plants, including tests of mutagenicity, teratogenicity and carcinogenicity seem to be still clearly necessary.

  3. Consumer choice: Linking consumer intentions to actual purchase of GM labeled food products

    NARCIS (Netherlands)

    Sleenhoff, S.; Osseweijer, P.

    2013-01-01

    With a mandatory labeling scheme for GM food in Europe since 2004 measuring actual consumer choice in practice has become possible. Anticipating Europeans negative attitude toward GM food, the labeling was enforced to allow consumers to make an informed choice. We studied consumers actual purchase b

  4. Non-target effects of GM potato : an eco-metabolomics approach

    NARCIS (Netherlands)

    Plischke, Andreas

    2013-01-01

    In this thesis, patterns of variation in plant metabolomes and insect communities were described in GM and non-GM potato plants in both laboratory and field experiments. Differences between plant genotypes in insect abundances were small when compared to year-to-year differences, location effects an

  5. Does insect netting affect the containment of airborne pollen from (GM-) plants in greenhouses?

    NARCIS (Netherlands)

    T. van Hengstum; D.A.P. Hooftman; H.C.M. den Nijs; P.H. van Tienderen

    2012-01-01

    Greenhouses are a well-accepted containment strategy to grow and study genetically modified plants (GM) before release into the environment. Various containment levels are requested by national regulations to minimize GM pollen escape. We tested the amount of pollen escaping from a standard greenhou

  6. Evolution of European GM-free standards: Reasoning of consumers and strategic adoption by companies

    NARCIS (Netherlands)

    Venus, T.J.; Wesseler, J.H.H.

    2015-01-01

    In this article, we discuss reasoning of consumers and strategic adoption behavior of producers and retailers with respect to genetically modified-free (GM-free) quality standards in Europe. We argue that there are three major reasons why a mandatory GM labeling scheme differs from a voluntary proce

  7. Safety assessment of GM plants: An updated review of the scientific literature.

    Science.gov (United States)

    Domingo, José L

    2016-09-01

    In a wide revision of the literature conducted in 2000, I noted that the information in scientific journals on the safety of genetically modified (GM) foods in general, and GM plants in particular, was scarce. Of course, it was not sufficient to guarantee that the consumption of these products should not mean risks for the health of the consumers. Because of the scientific interest in GM organisms (GMOs), as well as the great concern that the consumption of GM foods/plants has raised in a number of countries, I conducted two subsequent revisions (2007 and 2011) on the adverse/toxic effects of GM plants. In the present review, I have updated the information on the potential adverse health effects of GM plants consumed as food and/or feed. With only a few exceptions, the reported studies in the last six years show rather similar conclusions; that is to say, the assessed GM soybeans, rice, corn/maize and wheat would be as safe as the parental species of these plants. However, in spite of the notable increase in the available information, studies on the long-term health effects of GM plants, including tests of mutagenicity, teratogenicity and carcinogenicity seem to be still clearly necessary. PMID:27317828

  8. The corporate shaping of GM crops as a technology for the poor

    NARCIS (Netherlands)

    Glover, D.

    2010-01-01

    Genetically modified (GM, transgenic) crops are often invoked in debates about poverty, hunger, and agricultural development. The framing of GM crops as a 'pro-poor' and environmentally sustainable technology was partly a creation of the biotechnology industry, but cannot be explained as merely a cy

  9. Spectroscopic Characterization of Intermolecular Interaction of Amyloid β Promoted on GM1 Micelles

    Directory of Open Access Journals (Sweden)

    Maho Yagi-Utsumi

    2011-01-01

    Full Text Available Clusters of GM1 gangliosides act as platforms for conformational transition of monomeric, unstructured amyloid β (Aβ to its toxic β-structured aggregates. We have previously shown that Aβ(1–40 accommodated on the hydrophobic/hydrophilic interface of lyso-GM1 or GM1 micelles assumes α-helical structures under ganglioside-excess conditions. For better understanding of the mechanisms underlying the α-to-β conformational transition of Aβ on GM1 clusters, we performed spectroscopic characterization of Aβ(1–40 titrated with GM1. It was revealed that the thioflavin T- (ThT- reactive β-structure is more populated in Aβ(1–40 under conditions where the Aβ(1–40 density on GM1 micelles is high. Under this circumstance, the C-terminal hydrophobic anchor Val39-Val40 shows two distinct conformational states that are reactive with ThT, while such Aβ species were not generated by smaller lyso-GM1 micelles. These findings suggest that GM1 clusters promote specific Aβ-Aβ interactions through their C-termini coupled with formation of the ThT-reactive β-structure depending on sizes and curvatures of the clusters.

  10. Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis.

    Science.gov (United States)

    Piccoli, Luca; Campo, Ilaria; Fregni, Chiara Silacci; Rodriguez, Blanca Maria Fernandez; Minola, Andrea; Sallusto, Federica; Luisetti, Maurizio; Corti, Davide; Lanzavecchia, Antonio

    2015-01-01

    Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine their specificity for the self-antigen. Individual antibodies only partially neutralize GM-CSF activity using an in vitro bioassay, depending on the experimental conditions, while, when injected in mice together with human GM-CSF, they lead to the accumulation of a large pool of circulating GM-CSF that remains partially bioavailable. In contrast, a combination of three non-cross-competing antibodies completely neutralizes GM-CSF activity in vitro by sequestering the cytokine in high-molecular-weight complexes, and in vivo promotes the rapid degradation of GM-CSF-containing immune complexes in an Fc-dependent manner. Taken together, these findings provide a plausible explanation for the severe phenotype of PAP patients and for the safety of treatments based on single anti-GM-CSF monoclonal antibodies. PMID:26077231

  11. Consumer choice: Linking consumer intentions to actual purchase of GM labeled food products.

    Science.gov (United States)

    Sleenhoff, Susanne; Osseweijer, Patricia

    2013-01-01

    With a mandatory labeling scheme for GM food in Europe since 2004 measuring actual consumer choice in practice has become possible. Anticipating Europeans negative attitude toward GM food, the labeling was enforced to allow consumers to make an informed choice. We studied consumers actual purchase behavior of GM food products and compared this with their attitude and behavioral intention for buying GM food. We found that despite a majority of consumers voicing a negative attitude toward GM food over 50% of our European respondents stated that they did not actively avoid the purchase of GM food and 6% actually purchased one of the few available GM labeled food products in the period between September 2006 and October 2007. Our results imply that a voiced negative attitude of consumers in responses to questionnaires about their intentions is not a reliable guide for what they actually do in supermarkets. We conclude that the assumption of a negative attitude with regard to GM food is at least in part construed. PMID:24051512

  12. "It just goes against the grain." Public understandings of genetically modified (GM) food in the UK.

    Science.gov (United States)

    Shaw, Alison

    2002-07-01

    This paper reports on one aspect of qualitative research on public understandings of food risks, focusing on lay understandings of genetically modified (GM) food in the UK context. A range of theoretical, conceptual, and empirical literature on food, risk, and the public understanding of science are reviewed. The fieldwork methods are outlined and empirical data from a range of lay groups are presented. Major themes include: varying "technical" knowledge of science, the relationship between knowledge and acceptance of genetic modification, the uncertainty of scientific knowledge, genetic modification as inappropriate scientific intervention in "nature", the acceptability of animal and human applications of genetic modification, the appropriate boundaries of scientific innovation, the necessity for GM foods, the uncertainty of risks in GM food, fatalism about avoiding risks, and trust in "experts" to manage potential risks in GM food. Key discussion points relating to a sociological understanding of public attitudes to GM food are raised and some policy implications are highlighted.

  13. "It just goes against the grain." Public understandings of genetically modified (GM) food in the UK.

    Science.gov (United States)

    Shaw, Alison

    2002-07-01

    This paper reports on one aspect of qualitative research on public understandings of food risks, focusing on lay understandings of genetically modified (GM) food in the UK context. A range of theoretical, conceptual, and empirical literature on food, risk, and the public understanding of science are reviewed. The fieldwork methods are outlined and empirical data from a range of lay groups are presented. Major themes include: varying "technical" knowledge of science, the relationship between knowledge and acceptance of genetic modification, the uncertainty of scientific knowledge, genetic modification as inappropriate scientific intervention in "nature", the acceptability of animal and human applications of genetic modification, the appropriate boundaries of scientific innovation, the necessity for GM foods, the uncertainty of risks in GM food, fatalism about avoiding risks, and trust in "experts" to manage potential risks in GM food. Key discussion points relating to a sociological understanding of public attitudes to GM food are raised and some policy implications are highlighted. PMID:12430532

  14. GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization

    DEFF Research Database (Denmark)

    Rehn, Martin; Krarup, Peter-Martin; Christensen, Lise H;

    2015-01-01

    and immunohistochemical assessments were also performed. Finally, the direct effect of GM6001 on epithelialization was studied in cultured colonic epithelial cells. RESULTS: Unlike the robust beneficial effect on anastomosis under uncomplicated conditions, here GM6001 had a negative impact on anastomotic wound healing...... following colonic obstruction and substantially (p=0.004) more rats in the GM6001 group (75%) than in the control group (11%) had developed anastomotic leakage. In the anastomotic wounds, the myofibroblast abundance and cell proliferation were similar in the two groups. Histologically, GM6001 treatment...... resulted in wider and minimally epithelialized wounds that were commonly necrotic on the luminal side and infiltrated with numerous granulocytes. In vitro, GM6001 also delayed (p=0.026) epithelialization of denuded intestinal epithelium grown on type I collagen. CONCLUSIONS: Non-selective MMP...

  15. Determination of dose rates in beta radiation fields using extrapolation chamber and GM counter

    DEFF Research Database (Denmark)

    Borg, J.; Christensen, P.

    1995-01-01

    The extrapolation chamber measurement method is the basic method for the determination of dose rates in beta radiation fields and the method has been used for the establishment of beta calibration fields. The paper describes important details of the method and presents results from the measurement...... of depth-dose profiles from different beta radiation fields with E(max) values down to 156 keV. Results are also presented from studies of GM counters for use as survey instruments for monitoring beta dose rates at the workplace. Advantages of GM counters are a simple measurement technique and high...... sensitivity. GM responses were measured from exposures in different beta radiation fields using different filters in front of the GM detector and the paper discusses the possibility of using the results from GM measurements with two different filters in an unknown beta radiation field to obtain a value of the...

  16. A Meta Analysis on Farm-Level Costs and Benefits of GM Crops

    Directory of Open Access Journals (Sweden)

    Nataliya Stupak

    2011-05-01

    Full Text Available This paper reviews the evidence on the socio-economic impacts of GM crops and analyzes whether there are patterns across space and time. To this end, we investigate the effect of GM crops on farm-level costs and benefits using global data from more than one decade of field trials and surveys. More specifically, we analyze the effects of GM-crops on crop yields, seed costs, pesticide costs, and management and labor costs and finally gross margins. Based on collected data from studies on Bt cotton and Bt maize, statistical analyses are conducted to estimate the effect of GM crop adoption on these parameters. Our results show that, compared to conventional crops, GM crops can lead to yield increases and can lead to reductions in the costs of pesticide application, whereas seed costs are usually substantially higher. Thus, the results presented here do support the contention that the adoption of GM crops leads on average to a higher economic performance, which is also underlined by the high adoption rates for GM crops in a number of countries. However, the kind and magnitude of benefits from GM crops are very heterogeneous between countries and regions, particularly due to differences in pest pressure and pest management practices. Countries with poor pest management practices benefited most from a reduction in yield losses, whereas other countries benefited from cost reductions. However, our study also reveals limitations for meta-analyses on farm-level costs and benefits of GM crops. In particular, published data are skewed towards some countries and the employed individual studies rely on different assumptions, purposes and methodologies (e.g., surveys and field trials. Furthermore, a summary of several (often short-term individual studies may not necessarily capture long-term effects of GM crop adoption.

  17. EVOLUTION OF EUROPEAN GM-FREE STANDARDS: REASONING OF CONSUMERS AND STRATEGIC ADOPTION BY COMPANIES

    Directory of Open Access Journals (Sweden)

    Thomas J. VENUS

    2015-11-01

    Full Text Available In this article, we discuss reasoning of consumers and strategic adoption behavior of producers and retailers with respect to genetically modified-free (GM-free quality standards in Europe. We argue that there are three major reasons why a mandatory GM labeling scheme differs from a voluntary process-based GM-free labeling scheme regarding the effect on consumer demand: (1 while both mandatory and voluntary labels signal that products containing, or produced with genetically modified organisms (GMOs are of lower quality, experiments show that the signaling effect is stronger in the case of mandatory labels; (2 some consumers care more about the effects of consuming GMOs directly (i.e., labeled GMO compared to consuming only products derived from GMOs (i.e., non-labeled GM-free; and (3 mandatory labeling shifts some of the labeling burden to the GM producer making the GM product relatively more expensive compared to the case of voluntary GM-free labeling. We discuss reasons why producers or retailers set or implement a voluntary GM-free production standard. To illustrate how the firm adoption theory can be extended, we use a real option game framework in a duopolistic setting and show that it can be beneficial to offer a GM-free product without labeling it. We show that this can be the case if investing without labeling works as a pre-investment or option to extend to reduce the investment cost of implementing a label in the case of an increase in demand. Finally, we provide a list of important events that have affected the evolution of the GM-free market in Europe.

  18. Evolution of bulgeless low surface brightness galaxies

    Science.gov (United States)

    Shao, X.; Hammer, F.; Yang, Y. B.; Liang, Y. C.

    Based on the Sloan Digital Sky Survey DR 7, we investigate the environment, morphology, and stellar population of bulgeless low surface-brightness (LSB) galaxies in a volume-limited sample with redshift ranging from 0.024 to 0.04 and M r LSB galaxies have more young stars and are more metal-poor than regular LSB galaxies. These results suggest that the evolution of LSB galaxies may be driven by their dynamics, including mergers rather than by their large-scale environment.

  19. Raman beam combining for laser brightness enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, Jay W.; Allen, Graham S.; Pax, Paul H.; Heebner, John E.; Sridharan, Arun K.; Rubenchik, Alexander M.; Barty, Chrisopher B. J.

    2015-10-27

    An optical source capable of enhanced scaling of pulse energy and brightness utilizes an ensemble of single-aperture fiber lasers as pump sources, with each such fiber laser operating at acceptable pulse energy levels. Beam combining involves stimulated Raman scattering using a Stokes' shifted seed beam, the latter of which is optimized in terms of its temporal and spectral properties. Beams from fiber lasers can thus be combined to attain pulses with peak energies in excess of the fiber laser self-focusing limit of 4 MW while retaining the advantages of a fiber laser system of high average power with good beam quality.

  20. The radio properties of bright Seyfert galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Giuricin, G.; Mardirossian, F.; Mezzetti, M.; Bertotti, G. (Centro Interuniversitario Regionale per l' Astrofisica e la Cosmologia (Italy) Centre for Advanced Research in Space Optics (Italy))

    1990-03-01

    The radio properties of a sample of 69 bright spectroscopically selected Seyfert galaxies, which suffers from little bias toward Markarian galaxies with strong UV excess. At variance with most of the earlier results, generally based on galaxy samples which are strongly biased toward the inclusion of Markarian objects, there is no clear evidence of a significant difference in the major radio properties (radio power, radio-to-optical luminosity ratio, radio spectral index and radio size) of type 1 and type 2 Seyferts. The resulting observational scenario appears now to be more consistent than before with the idea that Seyfert 2 galaxies are simply Seyfert 1 obscured objects. 70 refs.

  1. Monitoring of bright blazars with MAGIC telescope

    OpenAIRE

    Hsu, C. C.; Satalecka, K.; Thom, M; Backes, M.; Bernardini, E.; Bonnoli, G.; Galante, N.; Goebel, F; Lindfors, E.; Majumdar, P.; Stamerra, A.; Wagner, R. M.

    2009-01-01

    Blazars, a class of Active Galactic Nuclei (AGN) characterized by a close orientation of their relativistic outflows (jets) towards the line of sight, are a well established extragalactic TeV $\\gamma$-ray emitters. Since 2006, three nearby and TeV bright blazars, Markarian (Mrk) 421, Mrk 501 and 1ES 1959+650, are regularly observed by the MAGIC telescope with single exposures of 30 to 60 minutes. The sensitivity of MAGIC allows to establish a flux level of 30% of the Crab flux for each such o...

  2. Quantum bright soliton in a disorder potential

    OpenAIRE

    Sacha, K.; Delande, D; Zakrzewski, J.

    2009-01-01

    At very low temperature, a quasi-one-dimensional ensemble of atoms with attractive interactions tend to form a bright soliton. When exposed to a sufficiently weak external potential, the shape of the soliton is not modified, but its external motion is affected. We develop in detail the Bogoliubov approach for the problem, treating, in a non-perturbative way, the motion of the center of mass of the soliton. Quantization of this motion allows us to discuss its long time properties. In particula...

  3. Effects of GM-CSF, IL-3, and GM-CSF/IL-3 fusion protein on apoptosis of human myeloid leukemic cell line Tf-1 induced by irradiation

    Institute of Scientific and Technical Information of China (English)

    Su-rongYANG; LiWEN; Ying-qingLU; Qin-yanGONG; RongYU; Ming-huiYAO

    2004-01-01

    AIM: To observe the effects of three cytokines on the apoptosis of Tf-1 cells induced by γ irradiation and investigate the relationship between apoptosis and caspase-3 activity. METHODS: Different cytokines GM-CSF, IL-3 and GM-CS/IL-3 fusion protein were added into the irradiated Tf-1 cells. MTT assay, morphology, flow cytometry,and DNA fragmentation assay were used to observe the effects of cytokines on apoptosis. The caspase-3 activity was determined with a fluorocytometer. RESULTS: Irradiated Tf-1 cells showed typical morphological characteristic of apoptosis demonstrated by transmission electron microscopy and were accumulated in G0/G1 phase. In the groups treated with growth factors after irradiation, three cytokines significantly increased the viability rate, distinctly decreased the apoptosis rate and the proportion of DNA fragmentation. When Tf-1 cells were irradiated by γ irradiation, caspase-3 activity was increased at different time points. In comparison with the control group in which no growth factor was added after the cells were irradiated, the caspase-3 activity of irradiated Tf-1 cells was significantly inhibited by addition of the above cytokines. Thirty-six hours after irradiation, in the control group,GM-CSF, IL-3, GM-CSF and IL-3 in combination, and two GM-CSF/IL-3 fusion protein groups, the apoptosis ratewas 73 %, 11%, 15 %, 13 %, 12 %, and 13 %. The percent of fragmented DNA was 36 %, 19 %, 18 %, 14 %,13 %, and 14 %. The fluorescence intensity was 16923, 5529, 6581, 5322, 5426, and 5485. CONCLUSION:GM-CSF, IL-3, and GM-CSF/IL-3 fusion protein could protect Tf-1 cells from apoptosis induced by γ irradiation.After Tf-1 cells were irradiated, the caspase-3 activity was significantly increased but was dramatically decreased by the above cytokines. The remarkable inhibition of caspase-3 activity may be one of the mechanisms of these hematopoietic growth factors exerting their anti-apoptotic effects.

  4. The role of the Fraunhofer lines in solar brightness variability

    CERN Document Server

    Shapiro, A I; Krivova, N A; Tagirov, R V; Schmutz, W K

    2015-01-01

    The solar brightness varies on timescales from minutes to decades. A clear identification of the physical processes behind such variations is needed for developing and improving physics-based models of solar brightness variability and reconstructing solar brightness in the past. This is, in turn, important for better understanding the solar-terrestrial and solar-stellar connections. We estimate the relative contributions of the continuum, molecular, and atomic lines to the solar brightness variations on different timescales. Our approach is based on the assumption that variability of the solar brightness on timescales greater than a day is driven by the evolution of the solar surface magnetic field. We calculated the solar brightness variations employing the solar disc area coverage of magnetic features deduced from the MDI/SOHO observations. The brightness contrasts of magnetic features relative to the quiet Sun were calculated with a non-LTE radiative transfer code as functions of disc position and waveleng...

  5. Imaging the photoevaporating disk and radio jet of GM Aur

    CERN Document Server

    Macias, Enrique; Osorio, Mayra; Calvet, Nuria; Torrelles, Jose M; Gomez, Jose F; Espaillat, Catherine; Lizano, Susana; Rodriguez, Luis F; Carrasco-Gonzalez, Carlos; Zapata, Luis

    2016-01-01

    Photoevaporation is probably the main agent for gas dispersal during the last stages of protoplanetary disk evolution. However, the overall mass loss rate in the photoevaporative wind and its driving mechanism are still not well understood. Here we report multi-configuration Very Large Array observations at 0.7, 3, and 5 cm towards the transitional disk of GM Aur. Our radio continuum observations allow us to image and spatially resolve, for the first time, the three main components at work in this stage of the disk evolution: the disk of dust, the ionized radio jet perpendicular to it, and the photoevaporative wind arising from the disk. The mass loss rate inferred from the flux density of the radio jet is consistent with the ratio between ejection and accretion rates found in younger objects, suggesting that transitional disks can power collimated ejections of material apparently following the same physical mechanisms as much younger protostars. Our results indicate that extreme-UV (EUV) radiation is the mai...

  6. Debaty o GM plodinách neutichají

    OpenAIRE

    Kuchtova, Perla; Kettnerova, Miloslava

    2013-01-01

    Zákazem kukuřice MON 810 (Monsanto) a brambor Amflora (BASF) se Polsko 2. ledna letošního roku připojilo k šesti evropským zemím, tedy Rakousku, Německu, Francii, Řecku, Maďarsku a Lucembursku, které zakazují na svém území pěstování geneticky modifikovaných (GM) plodin. Aktuálně je Polsko české spotřebitelské veřejnosti prezentováno jako nezodpovědný producent a vývozce pochybných až nebezpečných potravin, proto by ji mohla překvapit skutečnost, že polským úřadům leží na srdci rizika spojovan...

  7. GM crops, the environment and sustainable food production.

    Science.gov (United States)

    Raven, Peter H

    2014-12-01

    Today, over 7.1 billion people rely on the earth's resources for sustenance, and nearly a billion people are malnourished, their minds and bodies unable to develop properly. Globally, population is expected to rise to more than 9 billion by 2050. Given the combined pressures of human population growth, the rapidly growing desire for increased levels of consumption, and the continued use of inappropriate technologies, it is not surprising that humans are driving organisms to extinction at an unprecedented rate. Many aspects of the sustainable functioning of the natural world are breaking down in the face of human-induced pressures including our individual and collective levels of consumption and our widespread and stubborn use of destructive technologies. Clearly, agriculture must undergo a redesign and be better and more effectively managed so as to contribute as well as possible to feeding people, while at the same time we strive to lessen the tragic loss of biodiversity and damage to all of its productive systems that the world is experiencing. For GM crops to be part of the solution, biosafety assessments should not be overly politically-driven or a burdensome impedance to delivering this technology broadly. Biosafety scientists and policy makers need to recognize the undeniable truth that inappropriate actions resulting in indecision also have negative consequences. It is no longer acceptable to delay the use of any strategy that is safe and will help us achieve the ability to feed the world's people. PMID:24150918

  8. GM crops, the environment and sustainable food production.

    Science.gov (United States)

    Raven, Peter H

    2014-12-01

    Today, over 7.1 billion people rely on the earth's resources for sustenance, and nearly a billion people are malnourished, their minds and bodies unable to develop properly. Globally, population is expected to rise to more than 9 billion by 2050. Given the combined pressures of human population growth, the rapidly growing desire for increased levels of consumption, and the continued use of inappropriate technologies, it is not surprising that humans are driving organisms to extinction at an unprecedented rate. Many aspects of the sustainable functioning of the natural world are breaking down in the face of human-induced pressures including our individual and collective levels of consumption and our widespread and stubborn use of destructive technologies. Clearly, agriculture must undergo a redesign and be better and more effectively managed so as to contribute as well as possible to feeding people, while at the same time we strive to lessen the tragic loss of biodiversity and damage to all of its productive systems that the world is experiencing. For GM crops to be part of the solution, biosafety assessments should not be overly politically-driven or a burdensome impedance to delivering this technology broadly. Biosafety scientists and policy makers need to recognize the undeniable truth that inappropriate actions resulting in indecision also have negative consequences. It is no longer acceptable to delay the use of any strategy that is safe and will help us achieve the ability to feed the world's people.

  9. Panchromatic Imaging of a Transitional Disk: The Disk of GM Aur in Optical and FUV Scattered Light

    CERN Document Server

    Hornbeck, Jeremy; Grady, Carol; Williger, G; Broan, A; Sitko, M; Wisniewski, J; Perrin, M; Lauroesch, J; Schneider, G; Apai, D; Brittain, S; Brown, J; Champnew, E; Hamaguchi, K; Henning, T; Lynch, D; Petre, R; Russell, R; Walter, F; Woodgate, B

    2016-01-01

    We have imaged GM Aur with HST, detected its disk in scattered light at 1400A and 1650A, and compared these with observations at 3300A, 5550A, 1.1 microns, and 1.6 microns. The scattered light increases at shorter wavelengths. The radial surface brightness profile at 3300A shows no evidence of the 24AU radius cavity that has been previously observed in sub-mm observations. Comparison with dust grain opacity models indicates the surface of the entire disk is populated with sub-micron grains. We have compiled an SED from 0.1 microns to 1 mm, and used it to constrain a model of the star+disk system that includes the sub-mm cavity using the Monte Carlo Radiative Transfer code by Barbara Whitney. The best-fit model image indicates that the cavity should be detectable in the F330W bandpass if the cavity has been cleared of both large and small dust grains, but we do not detect it. The lack of an observed cavity can be explained by the presence of sub-microns grains interior to the sub-mm cavity wall. We suggest one...

  10. Coronal bright points associated with minifilament eruptions

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Junchao; Jiang, Yunchun; Yang, Jiayan; Bi, Yi; Li, Haidong [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Yang, Bo; Yang, Dan, E-mail: hjcsolar@ynao.ac.cn [Also at Graduate School of Chinese Academy of Sciences, Beijing, China. (China)

    2014-12-01

    Coronal bright points (CBPs) are small-scale, long-lived coronal brightenings that always correspond to photospheric network magnetic features of opposite polarity. In this paper, we subjectively adopt 30 CBPs in a coronal hole to study their eruptive behavior using data from the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory. About one-quarter to one-third of the CBPs in the coronal hole go through one or more minifilament eruption(s) (MFE(s)) throughout their lifetimes. The MFEs occur in temporal association with the brightness maxima of CBPs and possibly result from the convergence and cancellation of underlying magnetic dipoles. Two examples of CBPs with MFEs are analyzed in detail, where minifilaments appear as dark features of a cool channel that divide the CBPs along the neutral lines of the dipoles beneath. The MFEs show the typical rising movements of filaments and mass ejections with brightenings at CBPs, similar to large-scale filament eruptions. Via differential emission measure analysis, it is found that CBPs are heated dramatically by their MFEs and the ejected plasmas in the MFEs have average temperatures close to the pre-eruption BP plasmas and electron densities typically near 10{sup 9} cm{sup –3}. These new observational results indicate that CBPs are more complex in dynamical evolution and magnetic structure than previously thought.

  11. Sublimation in bright spots on (1) Ceres.

    Science.gov (United States)

    Nathues, A; Hoffmann, M; Schaefer, M; Le Corre, L; Reddy, V; Platz, T; Cloutis, E A; Christensen, U; Kneissl, T; Li, J-Y; Mengel, K; Schmedemann, N; Schaefer, T; Russell, C T; Applin, D M; Buczkowski, D L; Izawa, M R M; Keller, H U; O'Brien, D P; Pieters, C M; Raymond, C A; Ripken, J; Schenk, P M; Schmidt, B E; Sierks, H; Sykes, M V; Thangjam, G S; Vincent, J-B

    2015-12-10

    The dwarf planet (1) Ceres, the largest object in the main asteroid belt with a mean diameter of about 950 kilometres, is located at a mean distance from the Sun of about 2.8 astronomical units (one astronomical unit is the Earth-Sun distance). Thermal evolution models suggest that it is a differentiated body with potential geological activity. Unlike on the icy satellites of Jupiter and Saturn, where tidal forces are responsible for spewing briny water into space, no tidal forces are acting on Ceres. In the absence of such forces, most objects in the main asteroid belt are expected to be geologically inert. The recent discovery of water vapour absorption near Ceres and previous detection of bound water and OH near and on Ceres (refs 5-7) have raised interest in the possible presence of surface ice. Here we report the presence of localized bright areas on Ceres from an orbiting imager. These unusual areas are consistent with hydrated magnesium sulfates mixed with dark background material, although other compositions are possible. Of particular interest is a bright pit on the floor of crater Occator that exhibits probable sublimation of water ice, producing haze clouds inside the crater that appear and disappear with a diurnal rhythm. Slow-moving condensed-ice or dust particles may explain this haze. We conclude that Ceres must have accreted material from beyond the 'snow line', which is the distance from the Sun at which water molecules condense. PMID:26659183

  12. At Bright Band Inside Victoria Crater

    Science.gov (United States)

    2007-01-01

    A layer of light-toned rock exposed inside Victoria Crater in the Meridiani Planum region of Mars appears to mark where the surface was at the time, many millions of years ago, when an impact excavated the crater. NASA's Mars Exploration Rover Opportunity drove to this bright band as the science team's first destination for the rover during investigations inside the crater. Opportunity's left front hazard-identification camera took this image just after the rover finished a drive of 2.25 meters (7 feet, 5 inches) during the rover's 1,305th Martian day, or sol, (Sept. 25, 2007). The rocks beneath the rover and its extended robotic arm are part of the bright band. Victoria Crater has a scalloped shape of alternating alcoves and promontories around the crater's circumference. Opportunity descended into the crater two weeks earlier, within an alcove called 'Duck Bay.' Counterclockwise around the rim, just to the right of the arm in this image, is a promontory called 'Cabo Frio.'

  13. Globe at Night - Sky Brightness Monitoring Network

    Science.gov (United States)

    Cheung, Sze Leung; Pun, Jason Chun Shing; SO, Chu-wing; Shibata, Yukiko; Walker, Constance Elaine; Agata, Hidehiko

    2015-08-01

    The Global at Night - Sky Brightness Monitoring Network (GaN-MN) is an international project for long-term monitoring of night sky conditions around the world. The GaN-MN consists of fixed monitoring stations each equipped with a Sky Quality Meter - Lensed Ethernet (SQM-LE), which is a specialized light sensor for night sky brightness (NSB) measurement. NSB data are continuously collected at high sampling frequency throughout the night, and these data will be instantly made available to the general public to provide a real-time snapshot of the global light pollution condition. A single data collection methodology, including data sampling frequency, data selection criteria, device design and calibration, and schemes for data quality control, was adopted to ensure uniformity in the data collected. This is essential for a systematic and global study of the level of light pollution. The data collected will also provide the scientific backbone in our efforts to contribute to dark sky conservation through education to the general public and policy makers. The GaN-MN project is endorsed by the IAU IYL Executive Committee Working Group as a major Cosmic Light program in the International Year of Light.

  14. Mechanical electrodeposition of bright nanocrystalline nickel

    Institute of Scientific and Technical Information of China (English)

    ZHU ZengWei; ZHU Di; QU NingSong

    2008-01-01

    A new mechanical electrodeposition technology was proposed,and nanocrystal-line nickel deposit with bright and smooth surface was prepared in the bath without any additive agents.Unlike traditional methods,the novel technology employed dynamical hard particles to continuously polish the cathode surface and disturb the nearby solution during electrodepositing.Experimental results showed that the polishing effect of hard particles can effectively prevent the hydrogen bubbles and impurities from adhering on the deposit surface and avoid the production of pits,pinholes and nodules.Furthermore,comparing with the deposit prepared by tradi-tional methods,the one prepared by the novel technology was substantially refined with grain size ranging from 30 to 80 nm.Every diffraction peak's intensity of the deposit was reduced,the preferential orientation degree of (200) decreased and those of (111) and (220) increased.The microhardness notably increased.The magnetic properties were also changed with decreased saturation magnetization and increased coercive force.It was also found that variation of current density and cathode rotational speed could affect the structure and properties of the nickel deposits prepared by this technology.Key.words:electrodeposition,electroforming,hard particle,nanocrystalline,bright nickel deposits prepared by this technology.

  15. Coronal bright points associated with minifilament eruptions

    International Nuclear Information System (INIS)

    Coronal bright points (CBPs) are small-scale, long-lived coronal brightenings that always correspond to photospheric network magnetic features of opposite polarity. In this paper, we subjectively adopt 30 CBPs in a coronal hole to study their eruptive behavior using data from the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory. About one-quarter to one-third of the CBPs in the coronal hole go through one or more minifilament eruption(s) (MFE(s)) throughout their lifetimes. The MFEs occur in temporal association with the brightness maxima of CBPs and possibly result from the convergence and cancellation of underlying magnetic dipoles. Two examples of CBPs with MFEs are analyzed in detail, where minifilaments appear as dark features of a cool channel that divide the CBPs along the neutral lines of the dipoles beneath. The MFEs show the typical rising movements of filaments and mass ejections with brightenings at CBPs, similar to large-scale filament eruptions. Via differential emission measure analysis, it is found that CBPs are heated dramatically by their MFEs and the ejected plasmas in the MFEs have average temperatures close to the pre-eruption BP plasmas and electron densities typically near 109 cm–3. These new observational results indicate that CBPs are more complex in dynamical evolution and magnetic structure than previously thought.

  16. Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway.

    Science.gov (United States)

    Kundu, Manjari; Mahata, Barun; Banerjee, Avisek; Chakraborty, Sohini; Debnath, Shibjyoti; Ray, Sougata Sinha; Ghosh, Zhumur; Biswas, Kaushik

    2016-07-01

    The definitive role of ganglioside GM2 in mediating tumor-induced growth and progression is still unknown. Here we report a novel role of ganglioside GM2 in mediating tumor cell migration and uncovered its mechanism. Data shows differential expression levels of GM2-synthase as well as GM2 in different human cancer cells. siRNA mediated knockdown of GM2-synthase in CCF52, A549 and SK-RC-26B cells resulted in significant inhibition of tumor cell migration as well as invasion in vitro without affecting cellular proliferation. Over-expression of GM2-synthase in low-GM2 expressing SK-RC-45 cells resulted in a consequent increase in migration thus confirming the potential role GM2 and its downstream partners play in tumor cell migration and motility. Further, treatment of SK-RC-45 cells with exogenous GM2 resulted in a dramatic increase in migratory and invasive capacity with no change in proliferative capacity, thereby confirming the role of GM2 in tumorigenesis specifically by mediating tumor migration and invasion. Gene expression profiling of GM2-synthase silenced cells revealed altered expression of several genes involved in cell migration primarily those controlling the integrin mediated signaling. GM2-synthase knockdown resulted in decreased phosphorylation of FAK, Src as well as Erk, while over-expression and/or exogenous GM2 treatment caused increased FAK and Erk phosphorylation respectively. Again, GM2 mediated invasion and Erk phosphorylation is blocked in integrin knockdown SK-RC-45 cells, thus confirming that GM2 mediated migration and phosphorylation of Erk is integrin dependent. Finally, confocal microscopy suggested co-localization while co-immunoprecipitation and surface plasmon resonance (SPR) confirmed direct interaction of membrane bound ganglioside, GM2 with the integrin receptor.

  17. Gm and Km alleles in two Spanish Pyrenean populations (Andorra and Pallars Sobirà): a review of Gm variation in the Western Mediterranean basin.

    Science.gov (United States)

    Giraldo, M P; Esteban, E; Aluja, M P; Nogués, R M; Backés-Duró, C; Dugoujon, J M; Moral, P

    2001-11-01

    Two Spanish eastern Pyrenean populations, Andorra and Pallars Sobirà, have been tested for G1m(1,2,3,17), G2m(23), G3m(5,6,10,11,13,14,15,16,21,24,28) and Km(1) immunoglobulin allotypes. Km allele and Gm haplotype frequencies in both samples fit well into the Western Mediterranean and, more strictly, Pyrenean ranges with some peculiarities: Andorra showed an elevated frequency (14.7%) of the typical Asian and European Gm21,28;1,2,17;. haplotype, while Pallars Sobirà was characterized by high values (3.7%) of Gm5*;1,17;., a typical sub-Saharan Gm haplotype. Gm diversity assessed through genetic distance and variance analyses revealed a significant geographic partition (4.3%) of Mediterraneans among south, north-east, and north-west groups. It is interesting to note the relatively low genetic variance (2.1%) found between south and north-western Mediterraneans that could reflect ancient population relationships. More locally, genetic boundaries and diversity analyses failed to indicate any geographic pattern and/or genetic differentiation related with the political border in the Pyrenees. The present pattern of variation in this area is probably the result of genetic isolation processes, in addition to some specific demographic phenomena, in the Pyrenean valleys. PMID:11851984

  18. RISK MANAGEMENT AND EXPERTISE: UK: Strategies for Precautionary Commercialization of GM Crops

    Directory of Open Access Journals (Sweden)

    Levidow Les

    2000-07-01

    Full Text Available As genetically modified (GM products approach the market stage, the UK government and agro-food industry have faced a suspicious or hostile public. Since 1998 many retail chains have undertaken to exclude any GM-derived ingredients from their own-brand lines. This commercial blockage has intensified pressures for greater precaution, even for a moratorium on cultivating GM crops. Political protest has led to strategies for precautionary commercialization. Government and industry have cooperated to plan a “managed development” of GM crops. Across the agricultural supply chain, industry has devised voluntary guidelines to ensure segregation of GM crops and to limit the spread of GM herbicide-tolerance. In particular UK regulators seek to test the risk that broad-spectrum herbicide sprays could damage wildlife habitats; they have broadened the advisory expertise accordingly. These measures open up the precautionary content to further debate, at both national and EU levels. Market-stage precautions establish a means to test claims that GM crops are environmentally-friendly products. By translating public concerns into broader risk-assessment criteria, the UK procedure involves critics in potentially influencing standards of scientific evidence and environmental harm. This social process has become a prerequisite for legitimizing commercial use.

  19. Genetically modified food in the news: media representations of the GM debate in the UK.

    Science.gov (United States)

    Augoustinos, Martha; Crabb, Shona; Shepherd, Richard

    2010-01-01

    This paper analyses a corpus of articles on GM crops and food which appeared in six UK newspapers in the first three months of 2004, the year following the GM Nation? debate (2003). Using the methods of critical discourse analysis we focus on how specific and pervasive representations of the major stakeholders in the national debate on GM--the British public, the British government, the science of GM, and biotechnology companies--served significant rhetorical functions in the controversy. Of particular significance was the pervasive representation of the British public as uniformly opposed to GM crops and food which served rhetorically to position the British government as undemocratic and as being beholden to powerful political and economic interests. Of significance also in our analysis, is how the science of GM farming itself became a highly contested arena. In short, our analysis demonstrates how the GM debate was represented in the newsprint media as a "battleground" of competing interests. We conclude by considering the possible implications of this representation given the increasing emphasis placed on the importance of deliberative and inclusive forms of science policy decision-making. PMID:20533793

  20. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Science.gov (United States)

    Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-Ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi

    2011-01-01

    To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease. PMID:22205997

  1. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Directory of Open Access Journals (Sweden)

    Takashi Kodama

    Full Text Available To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2 levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  2. Responses to GM food content in context with food integrity issues: results from Australian population surveys.

    Science.gov (United States)

    Mohr, Philip; Golley, Sinéad

    2016-01-25

    This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives.

  3. Stimulatory versus suppressive effects of GM-CSF on tumor progression in multiple cancer types

    Science.gov (United States)

    Hong, In-Sun

    2016-01-01

    Granulocyte-macrophage colony-stimulating factor (GM-CSF, also called CSF-2) is best known for its critical role in immune modulation and hematopoiesis. A large body of experimental evidence indicates that GM-CSF, which is frequently upregulated in multiple types of human cancers, effectively marks cancer cells with a ‘danger flag' for the immune system. In this context, most studies have focused on its function as an immunomodulator, namely its ability to stimulate dendritic cell (DC) maturation and monocyte/macrophage activity. However, recent studies have suggested that GM-CSF also promotes immune-independent tumor progression by supporting tumor microenvironments and stimulating tumor growth and metastasis. Although some studies have suggested that GM-CSF has inhibitory effects on tumor growth and metastasis, an even greater number of studies show that GM-CSF exerts stimulatory effects on tumor progression. In this review, we summarize a number of findings to provide the currently available information regarding the anticancer immune response of GM-CSG. We then discuss the potential roles of GM-CSF in the progression of multiple types of cancer to provide insights into some of the complexities of its clinical applications. PMID:27364892

  4. Response to issues on GM agriculture in Africa: Are transgenic crops safe?

    Directory of Open Access Journals (Sweden)

    Adenle Ademola A

    2011-10-01

    Full Text Available Abstract The controversies surrounding transgenic crops, often called Genetically Modified Organisms (GMOs, call for a need to raise the level of public awareness of Genetic Modification (GM technology in Africa. This should be accomplished by educating the public about the potential benefits and risks that may be associated with this new technology. In the last 15 years, GM crop producing countries have benefited from adoption of this new technology in the form of improved crop productivity, food security, and quality of life. The increased income to resource-poor farmers is a key benefit at the individual level especially as most countries using this technology are in the developing world, including three African countries (South Africa, Burkina Faso and Egypt. Despite clear benefits to countries and farmers who grow GMOs, many people are concerned about suspected potential risks associated with GMOs. This sparks debate as to whether GM technology should be adopted or not. Given the concerns regarding the safety of GMO products, thorough scientific investigation of safe application of GMOs is required. The objective of this paper is to respond to the issues of GM agriculture in Africa and some of the issues surrounding the adoption of GM crops between developed and developing countries. In this article, I analyse relevant papers relating to the adoption of GM technology particularly in developing countries including the few African countries that have adopted GM crops. The issues discussed span a wide range including: safety; potential benefits and risks; disputes between the United States of America (USA and the European Union (EU over adoption of GM crops with a focus on Africa continent. This article is concluded by summarising the issues raised and how GM technology can be adopted for agricultural development in Africa.

  5. Response to issues on GM agriculture in Africa: Are transgenic crops safe?

    Science.gov (United States)

    Adenle, Ademola A

    2011-01-01

    The controversies surrounding transgenic crops, often called Genetically Modified Organisms (GMOs), call for a need to raise the level of public awareness of Genetic Modification (GM) technology in Africa. This should be accomplished by educating the public about the potential benefits and risks that may be associated with this new technology. In the last 15 years, GM crop producing countries have benefited from adoption of this new technology in the form of improved crop productivity, food security, and quality of life. The increased income to resource-poor farmers is a key benefit at the individual level especially as most countries using this technology are in the developing world, including three African countries (South Africa, Burkina Faso and Egypt). Despite clear benefits to countries and farmers who grow GMOs, many people are concerned about suspected potential risks associated with GMOs. This sparks debate as to whether GM technology should be adopted or not. Given the concerns regarding the safety of GMO products, thorough scientific investigation of safe application of GMOs is required. The objective of this paper is to respond to the issues of GM agriculture in Africa and some of the issues surrounding the adoption of GM crops between developed and developing countries. In this article, I analyse relevant papers relating to the adoption of GM technology particularly in developing countries including the few African countries that have adopted GM crops. The issues discussed span a wide range including: safety; potential benefits and risks; disputes between the United States of America (USA) and the European Union (EU) over adoption of GM crops with a focus on Africa continent. This article is concluded by summarising the issues raised and how GM technology can be adopted for agricultural development in Africa. PMID:21981823

  6. Granulocyte macrophage colony stimulating factor (GM-CSF biological actions on human dermal fibroblasts

    Directory of Open Access Journals (Sweden)

    S Montagnani

    2009-12-01

    Full Text Available Fibroblasts are involved in all pathologies characterized by increased ExtraCellularMatrix synthesis, from wound healing to fibrosis. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF is a cytokine isolated as an hemopoietic growth factor but recently indicated as a differentiative agent on endothelial cells. In this work we demonstrated the expression of the receptor for GM-CSF (GMCSFR on human normal skin fibroblasts from healthy subjects (NFPC and on a human normal fibroblast cell line (NHDF and we try to investigate the biological effects of this cytokine. Human normal fibroblasts were cultured with different doses of GM-CSF to study the effects of this factor on GMCSFR expression, on cell proliferation and adhesion structures. In addition we studied the production of some Extra-Cellular Matrix (ECM components such as Fibronectin, Tenascin and Collagen I. The growth rate of fibroblasts from healthy donors (NFPC is not augmented by GM-CSF stimulation in spite of increased expression of the GM-CSFR. On the contrary, the proliferation of normal human dermal fibroblasts (NHDF cell line seems more influenced by high concentration of GM-CSF in the culture medium. The adhesion structures and the ECM components appear variously influenced by GM-CSF treatment as compared to fibroblasts cultured in basal condition, but newly only NHDF cells are really induced to increase their synthesis activity. We suggest that the in vitro treatment with GM-CSF can shift human normal fibroblasts towards a more differentiated state, due or accompanied by an increased expression of GM-CSFR and that such “differentiation” is an important event induced by such cytokine.

  7. MafB antagonizes phenotypic alteration induced by GM-CSF in microglia

    Energy Technology Data Exchange (ETDEWEB)

    Koshida, Ryusuke, E-mail: rkoshida-myz@umin.ac.jp; Oishi, Hisashi, E-mail: hoishi@md.tsukuba.ac.jp; Hamada, Michito; Takahashi, Satoru

    2015-07-17

    Microglia are tissue-resident macrophages which are distributed throughout the central nervous system (CNS). Recent studies suggest that microglia are a unique myeloid population distinct from peripheral macrophages in terms of origin and gene expression signature. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a pleiotropic cytokine regulating myeloid development, has been shown to stimulate proliferation and alter phenotype of microglia in vitro. However, how its signaling is modulated in microglia is poorly characterized. MafB, a bZip transcriptional factor, is highly expressed in monocyte-macrophage lineage cells including microglia, although its role in microglia is largely unknown. We investigated the crosstalk between GM-CSF signaling and MafB by analyzing primary microglia. We found that Mafb-deficient microglia grew more rapidly than wild-type microglia in response to GM-CSF. Moreover, the expression of genes associated with microglial differentiation was more downregulated in Mafb-deficient microglia cultured with GM-CSF. Notably, such differences between the genotypes were not observed in the presence of M-CSF. In addition, we found that Mafb-deficient microglia cultured with GM-CSF barely extended their membrane protrusions, probably due to abnormal activation of RhoA, a key regulator of cytoskeletal remodeling. Altogether, our study reveals that MafB is a negative regulator of GM-CSF signaling in microglia. These findings could provide new insight into the modulation of cytokine signaling by transcription factors in microglia. - Highlights: • GM-CSF alters the phenotype of microglia in vitro more potently than M-CSF. • Transcription factor MafB antagonizes the effect of GM-CSF on microglia in vitro. • MafB deficiency leads to RhoA activation in microglia in response to GM-CSF. • We show for the first time the function of MafB in microglia.

  8. CARD9 Deficiency and Spontaneous Central Nervous System Candidiasis: Complete Clinical Remission With GM-CSF Therapy

    OpenAIRE

    Gavino, Christina; Cotter, Anthony; Lichtenstein, Daniel; Lejtenyi, Duncan; Fortin, Claude; Legault, Catherine; Alirezaie, Najmeh; Majewski, Jacek; Sheppard, Donald C; Behr, Marcel A.; Foulkes, William D.; Vinh, Donald C.

    2014-01-01

    We demonstrate autosomal-recessive CARD9 deficiency in a patient with relapsing Candida albicans meningoencephalitis. The novel, hypomorphic mutation impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) but not Th17 responses. Adjunctive GM-CSF therapy resulted in clinical remission, suggesting that a CARD9/GM-CSF axis contributes to susceptibility to candidiasis.

  9. INVESTIGATION ON THE CAUSES OF EUCALYPTUS KRAFT PULP BRIGHTNESS REVERSION

    Directory of Open Access Journals (Sweden)

    Kátia M. M. Eiras

    2005-12-01

    Full Text Available Some high brightness eucalyptus Kraft pulps have shown poor brightness stability. In most cases, the causes have notbeen identified and permanent solutions have not been found. This work focused on evaluating the brightness stability profile of pulpsbleached by in sequences such as O(DC(PODD, O(DC(PODP, OD(PODD, OD(PODP, ODHT(PODD, ODHT(PODP, OA/D(PODD, OA/D(PODP, OAD(PODD and O(ZeD(PO. Brightness stability tests induced by according to Tappi UM200 procedureon samples bleached to 90±0.5% ISO. Brightness stability was measured after each bleaching stage of the various sequences andexpressed as brightness loss in % ISO. The results indicate that pulps bleached with sequences ending with a peroxide stage havehigher brightness stability compared to those ending with a chlorine dioxide stage. Pulps bleached with a standard sequence, initiatingwith a (DC stage, show brightness stability similar to that of pulp bleached by an ECF (Elementary chlorine free sequence initiatingwith a regular D0 stage. ECF sequences, initiated with hot stages produce pulps with higher brightness stability than sequencesinitiating with a regular D0 stage. The profile across the bleaching sequences shows a tendency of increased brightness stability inalkaline stages containing peroxide and decreased stability in those stages containing chlorine and/or chlorine dioxide, parallelingpulp carbonyl group content.

  10. Responding to Expert Arguments. Emerging Lay Topoi in Focus Group Interviews on GM-Crops

    DEFF Research Database (Denmark)

    Horsbøl, Anders

    2009-01-01

    This paper challenges the view that attitudes towards genetically modified (GM) crops in agriculture are "utterly resistant to persuasion", as Scholderer (2005) humorously suggests in a review of the literature. Methodologically, this is achieved by studying opinions as they emerge in situated...... interaction (Myers 2004), in casu in focus groups interviews with both GM-experts and lay persons without specific knowledge on GM-crops. The paper analyses the lay persons' responses to persuasive expert utterances as inventive contributions to the discussion, not just as reactions showing either support...

  11. Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells

    OpenAIRE

    Perrem, Kilian; Colgin, Lorel M.; Neumann, Axel A.; Yeager, Thomas R.; Reddel, Roger R

    2001-01-01

    It has been shown previously that some immortalized human cells maintain their telomeres in the absence of significant levels of telomerase activity by a mechanism referred to as alternative lengthening of telomeres (ALT). Cells utilizing ALT have telomeres of very heterogeneous length, ranging from very short to very long. Here we report the effect of telomerase expression in the ALT cell line GM847. Expression of exogenous hTERT in GM847 (GM847/hTERT) cells resulted in lengthening of the sh...

  12. Saldenioichthys remotus gen. et sp. nov. (Teleostei, Perciformes and other acanthomorph remains from the Maastrichtian Saldeño Formation (Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    A. López-Arbarello

    2003-01-01

    Full Text Available Some isolated acanthomorph remains and a new taxon of perciform fishes, Saldenioichthys remotus gen. et sp. nov., from the Maastrichtian Saldeño Formation of Mendoza province, Argentina, are described and their systematic affinities are discussed. The new taxon is represented by a single incomplete, but well preserved postcranial skeleton. With the exception of a fully developed neural spine on the second preural centrum, it agrees with the generalized skeletal features of basal percoids, in particular the generalized perciform caudal skeleton. The only other Mesozoic perciform skeletal remains known so far are Nardoichthys, from the upper Campanian-lower Maastrichtian of Nardo (Italy and Eoserranus from the Upper Cretaceous Lameta Formation (India. Therefore, the new perciform taxon from the Saldeño Formation represents one of the oldest members of this group, and due to its peculiar combination of primitive and derived characters, it raises several questions regarding character evolution on this lineage. Es werden einige isolierte Reste acanthomorpher Fische sowie ein neues Taxon der Perciformes, Saldenioichthys remotus gen. et sp. nov., aus dem Maastricht der Saldeño Formation in der Provinz Mendoza, Argentinien, werden beschrieben und ihre systematische Stellung wird diskutiert. Das neue Taxon ist durch ein einziges, unvollständiges, aber gut erhaltenes postkraniales Skelett repräsentiert. Mit Ausnahme eines vollstandig ausgebildeten Dornfortsatzes auf dem ersten präuralen Zentrum stimmt es mit der generalisierten Skelettmorphologie basaler Percoiden überein, insbesondere mit dem generalisierten perciformen Caudal-Skelett. Die einzigen anderen Skelettreste von Perciformen aus dem Mesozoikum sind Nardoichthys aus dem Ober-Campan/Unter-Maastricht von Nardo, Italien, und Eoserranus aus der Oberkreide der Lameta Formation, Indien, und die Gruppe ist ansonsten praktisch nur aus känozoischen Sedimenten bekannt. Somit stellt das neue Taxon

  13. Comparison of drought stress response and gene expression between a GM maize variety and a near-isogenic non-GM variety.

    Science.gov (United States)

    Gullì, Mariolina; Salvatori, Elisabetta; Fusaro, Lina; Pellacani, Claudia; Manes, Fausto; Marmiroli, Nelson

    2015-01-01

    Maize MON810, grown and commercialised worldwide, is the only cultivated GM event in the EU. Maize MON810, variety DKC6575, and the corresponding near-isogenic line Tietar were studied in different growth conditions, to compare their behaviour in response to drought. Main photosynthetic parameters were significantly affected by drought stress in both GM and non-GM varieties to a similar extent. Though DKC6575 (GM) had a greater sensitivity in the early phase of stress response as compared with Tietar (non-GM), after six days of stress they behaved similarly, and both varieties recovered from stress damage. Profiling gene expression in water deficit regimes and in a generalised drought stress condition showed an up-regulation of many stress-responsive genes, but a greater number of differentially expressed genes was observed in Tietar, with genes belonging to transcription factor families and genes encoding heat shock proteins, late embryogenesis abundant proteins and detoxification enzymes. Since induction of these genes have been indicated from the literature as typical of stress responses, their activation in Tietar rather than in DKC6575 may be reminiscent of a more efficient response to drought. DKC6575 was also analysed for the expression of the transgene CryIAb (encoding the delta-endotoxin insecticidal protein) in water deficit conditions. In all the experiments, the CryIAb transcript was not influenced by drought stress, but was expressed at a constant level. This suggests that though possessing a different pattern of sensitivity to stress, the GM variety maintains the same expression level for the transgene. PMID:25692547

  14. Comparison of drought stress response and gene expression between a GM maize variety and a near-isogenic non-GM variety.

    Directory of Open Access Journals (Sweden)

    Mariolina Gullì

    Full Text Available Maize MON810, grown and commercialised worldwide, is the only cultivated GM event in the EU. Maize MON810, variety DKC6575, and the corresponding near-isogenic line Tietar were studied in different growth conditions, to compare their behaviour in response to drought. Main photosynthetic parameters were significantly affected by drought stress in both GM and non-GM varieties to a similar extent. Though DKC6575 (GM had a greater sensitivity in the early phase of stress response as compared with Tietar (non-GM, after six days of stress they behaved similarly, and both varieties recovered from stress damage. Profiling gene expression in water deficit regimes and in a generalised drought stress condition showed an up-regulation of many stress-responsive genes, but a greater number of differentially expressed genes was observed in Tietar, with genes belonging to transcription factor families and genes encoding heat shock proteins, late embryogenesis abundant proteins and detoxification enzymes. Since induction of these genes have been indicated from the literature as typical of stress responses, their activation in Tietar rather than in DKC6575 may be reminiscent of a more efficient response to drought. DKC6575 was also analysed for the expression of the transgene CryIAb (encoding the delta-endotoxin insecticidal protein in water deficit conditions. In all the experiments, the CryIAb transcript was not influenced by drought stress, but was expressed at a constant level. This suggests that though possessing a different pattern of sensitivity to stress, the GM variety maintains the same expression level for the transgene.

  15. The in vivo gene expression profile of the rAAV-2-hGM-CSF,rAAV-2-mGM-CSF vector modified bone marrow mesenchymal stem cell%rAAV-2-hGM-CSF、rAAV-2mGM-CSF转导骨髓间充质干细胞的在体基因表达

    Institute of Scientific and Technical Information of China (English)

    谢政军; 尹芳; 周淑芸

    2008-01-01

    Objective To observe the in vivo gene expression profile of the recombinant adenoassociated-2 virus mediated human GM-CSF, mouse GM-CSF (rAAV-2-hGM-CSF, rAAV-2-mGM-CSE )vector modified bone marrow mesenchymal stem cell (BMSC). Methods We transduced the BMSC by rAAV-2-hGM-CSF, rAAV-2-mGM-CSF at the condition which have acquired before respectively, then transfused the in vitro gene modified BMSC after 12 days proliferation in vitro to 6 weeks old nude mice through tail vein,while the BMSC transfused in control group hadn' t been gene modified. 2, 4, 6, 8 weeks after transfusion, count the total white blood cells and detect the hGM-CSF, mGM-CSF concentration in nude mice serum at that time point. Results Nude mice serum hGM-CSF levels were 23.77, 25.32, 19.77, 15.25 ng/L at 2, 4, 6, 8 weeks after transfusion compare to 36.25 ng/L, the in vitro level before transfusion; mGM-CSF levels were 34.96, 34.84, 35.50, 32.93 ng/L at 2, 4, 6, 8 weeks after transfusion compare to 25.14 ng/L, the in vitro level before transfusion; at the same time point the nude mice serum mGM-CSF levels were 17.34,17.44, 14.68, 16.85 ng/L in control group, rAAV-2-mGM-CSF transduced BMSC made the nude mice white blood cell count increased, but no changes in nude mice white blood cell count at rAAV-2-hGM-CSFtransduced BMSC and control group. Conclusion BMSC as a gene therapy vehicle, it can be gene modified in vitro, then the gene modified BMSC could let the therapeutic gene to have therapeutic effects in vivo.%目的 观察经rAAV-2-hGM-CSF、rAAV-2-mGM-CSF基因转导修饰的骨髓间充质干细胞在体基因表达情况.方法 按预先摸索好的转染条件在体外用rAAV-2-hGM-CSF、rAAV-2-mGM-CSF感染骨髓间充质干细胞后,继续在体外扩增培养12 d,再将被基因修饰的骨髓间充质干细胞通过尾静脉回输到6周龄的裸鼠体内,对照组回输未经基因转导处理的骨髓间充质干细胞,分别于此后的2、4、6、8周处死裸鼠,取其外周

  16. Modelling Solar and Stellar Brightness Variabilities

    Science.gov (United States)

    Yeo, K. L.; Shapiro, A. I.; Krivova, N. A.; Solanki, S. K.

    2016-04-01

    Total and spectral solar irradiance, TSI and SSI, have been measured from space since 1978. This is accompanied by the development of models aimed at replicating the observed variability by relating it to solar surface magnetism. Despite significant progress, there remains persisting controversy over the secular change and the wavelength-dependence of the variation with impact on our understanding of the Sun's influence on the Earth's climate. We highlight the recent progress in TSI and SSI modelling with SATIRE. Brightness variations have also been observed for Sun-like stars. Their analysis can profit from knowledge of the solar case and provide additional constraints for solar modelling. We discuss the recent effort to extend SATIRE to Sun-like stars.

  17. Hybrid quantum repeater using bright coherent light.

    Science.gov (United States)

    van Loock, P; Ladd, T D; Sanaka, K; Yamaguchi, F; Nemoto, Kae; Munro, W J; Yamamoto, Y

    2006-06-23

    We describe a quantum repeater protocol for long-distance quantum communication. In this scheme, entanglement is created between qubits at intermediate stations of the channel by using a weak dispersive light-matter interaction and distributing the outgoing bright coherent-light pulses among the stations. Noisy entangled pairs of electronic spin are then prepared with high success probability via homodyne detection and postselection. The local gates for entanglement purification and swapping are deterministic and measurement-free, based upon the same coherent-light resources and weak interactions as for the initial entanglement distribution. Finally, the entanglement is stored in a nuclear-spin-based quantum memory. With our system, qubit-communication rates approaching 100 Hz over 1280 km with fidelities near 99% are possible for reasonable local gate errors.

  18. High brightness angled cavity quantum cascade lasers

    Energy Technology Data Exchange (ETDEWEB)

    Heydari, D.; Bai, Y.; Bandyopadhyay, N.; Slivken, S.; Razeghi, M., E-mail: razeghi@eecs.northwestern.edu [Center for Quantum Devices, Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, Illinois 60208 (United States)

    2015-03-02

    A quantum cascade laser (QCL) with an output power of 203 W is demonstrated in pulsed mode at 283 K with an angled cavity. The device has a ridge width of 300 μm, a cavity length of 5.8 mm, and a tilt angle of 12°. The back facet is high reflection coated, and the front facet is anti-reflection coated. The emitting wavelength is around 4.8 μm. In distinct contrast to a straight cavity broad area QCL, the lateral far field is single lobed with a divergence angle of only 3°. An ultrahigh brightness value of 156 MW cm{sup −2 }sr{sup −1} is obtained, which marks the brightest QCL to date.

  19. Brightness temperature for 166 radio sources

    Institute of Scientific and Technical Information of China (English)

    Jun-Hui Fan; Yong Huang; Yu-Hai Yuan; Jiang-He Yang; Yi Liu; Jun Tao; Ying Gao; Tong-Xu Hua; Rui-Guang Lin; Jiang-Shui Zhang; Jing-Yi Zhang; Yi-Ping Qin

    2009-01-01

    Using the database of the University of Michigan Radio Astronomy Observatory (UMRAO) at three radio frequencies (4.8, 8 and 14.5 GHz), we determined the short-term variability timescales for 166 radio sources. The timescales are 0.15d (2007+777) to 176.17d (0528-250) with an average timescale of △tobs=17.1±16.5d for the whole sample. The timescales are used to calculate the brightness temperatures, TB. The value of log TB is in the range of log TB = 10.47 to 19.06 K. In addition, we also estimated the boosting factor for the sources. The correlation between the polarization and the Doppler factor is also discussed.

  20. Tunneling Dynamics Between Atomic Bright Solitons

    CERN Document Server

    Zhao, Li-Chen; Yang, Zhan-Ying; Yang, Wen-Li

    2016-01-01

    We investigate tunneling behavior between two bright solitons in a Bose-Einstein condensate with attractive contact interactions between atoms. The explicit tunneling properties including tunneling particles and oscillation period are described analytically, which indicates that the periodic tunneling form is a nonlinear Josephson type oscillation. The results suggest that the breathing behavior of solitons comes from the tunneling mechanism in an effective double-well potential, which is quite different from the modulational instability mechanism for Akhmediev breather and K-M breather. Furthermore, we obtain a phase diagram for two soliton interaction which admits tunneling property, particle-like property, interference property, and a resonant interaction case. The explicit conditions for them are clarified based on the defined critical distance $d_c$ and spatial interference period $D$.

  1. Considerations for high-brightness electron sources

    International Nuclear Information System (INIS)

    Particle accelerators are now used in many areas of physics research and in industrial and medical applications. New uses are being studied to address major societal needs in energy production, materials research, generation of intense beams of radiation at optical and suboptical wavelengths, treatment of various kinds of waste, and so on. Many of these modern applications require a high intensity beam at the desired energy, along with a very good beam quality in terms of the beam confinement, aiming, or focusing. Considerations for ion and electron accelerators are often different, but there are also many commonalties, and in fact, techniques derived for one should perhaps more often be considered for the other as well. We discuss some aspects of high-brightness electron sources here from that point of view. 6 refs

  2. Dark Skies, Bright Kids Year 7

    Science.gov (United States)

    Bittle, Lauren E.; Johnson, Kelsey E.; Borish, H. Jacob; Burkhardt, Andrew; Firebaugh, Ariel; Hancock, Danielle; Rochford Hayes, Christian; Linden, Sean; Liss, Sandra; Matthews, Allison; Prager, Brian; Pryal, Matthew; Sokal, Kimberly R.; Troup, Nicholas William; Wenger, Trey

    2016-01-01

    We present updates from our seventh year of operation including new club content, continued assessments, and our fifth annual Star Party. Dark Skies, Bright Kids (DSBK) is an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in Central Virginia through fun, hands-on activities that introduce basic Astronomy concepts. Our primary focus is hosting an 8-10 week after-school astronomy club at underserved elementary and middle schools. Each week, DSBK volunteers take the role of coaches to introduce astronomy-related concepts ranging from the Solar System to galaxies to astrobiology, and to lead students in interactive learning activities. Another hallmark of DSBK is hosting our Annual Central Virginia Star Party, a free event open to the community featuring star-gazing and planetarium shows.

  3. Morfometría de la escarpa de falla histórica identificada al norte del cerro La Cal, zona de falla La Cal, Mendoza Morphometry of the historic fault scarp identfied north of Cerro La Cal, La Cal Fault Zone, Mendoza

    Directory of Open Access Journals (Sweden)

    F. Mingorance

    2006-12-01

    Full Text Available Investigación morfométrica y paleosísmica histórica fue llevada a cabo en el Norte de Mendoza con el objeto de caracterizar y cuantificar a las evidencias geomorfológicas de ruptura superficial histórica identificadas en el sector septentrional de la zona de falla La Cal. Integración e interpretación de datos e información científica multidisciplinaria, sugieren fuertemente que la ruptura superficial histórica identificada estuvo asociada al terremoto destructivo de Mendoza ocurrido en 1861. La deformación superficial histórica ocurrió casi en su totalidad a lo largo de una escarpa prehistórica previa, mediante una combinación de fallamiento de corrimiento y plegamiento cercano a la superficie. Dos elementos de pendiente históricos de bajo relieve fueron reconocidos en la escarpa compuesta Villavicencio Sur, los cuales se diferencian de la típica secuencia de formas desarrollada en escarpas de falla normal históricas. El "remanente de cara libre", el elemento de pendiente superior, y la "pendiente de colapso", el elemento inferior, son controlados por la fricción interna y por la gravedad y la fricción de deslizamiento del material aluvial, respectivamente. La metodología paleosísmica histórica discutida en este trabajo, parece ser particularmente útil en el período de tiempo que cubre la mayor parte del registro histórico de terremotos destructivos en Argentina, los pasados 350 años, lapso en el cual la mayoría de los métodos de datación absoluta no son muy efectivos.Morphometric and historic paleoseismic research was conducted in northern Mendoza in order to characterize and quantify the geomorphic evidences of historic surface rupture identified on the northern part of the La Cal fault zone. Integration and interpretation of multidisciplinary data and information strongly suggest that the identified historic surface rupture was associated with the devastating Mendoza Earthquake occurred in 1861. The historic

  4. THE PROCESS OF ADMINISTRATION OF THE UNIVERSITY EXTENSION OF THE UNIVERSITY INSTITUTE OF TECHNOLOGY DR. DOLPHIN MENDOZA IN THE MUNICIPALITY TUCUPITA, STATE DELTA AMACURO / EL PROCESO DE GESTIÓN DE LA EXTENSIÓN UNIVERSITARIA DEL INSTITUTO UNIVERSITARIO DE TECNOLOGÍA DR. DELFÍN MENDOZA EN EL MUNICIPIO TUCUPITA, ESTADO DELTA AMACURO

    Directory of Open Access Journals (Sweden)

    Wilman del Valle Gómez

    2013-06-01

    Full Text Available The university extension as essential function of the university is sustained in its relationships with the community intra and extrauniversity, contributing to its transformation and to improve the quality of life of its members. In the University Institute of Technology Dr. Defín Mendoza, a problem is presented in the administration of this process for what intends to elaborate a strategy for he to strengthen the process of university extension, like part of fomenting a wider cultural system. In this way it will put on the institution to the service of the non alone community from inside its but also using the approaches that the university institutions are to the service of the Venezuelan population's economic, social and cultural development.

  5. Patrones fenológicos de la Provincia de Mendoza, Argentina, mediante serie temporal de imágenes NOAA-AVHRR NDVI GAC Phenological patterns of the province of Mendoza, Argentina, through a temporal series of NOAA-AVHRR NDVI GAC images

    Directory of Open Access Journals (Sweden)

    M. M González Loyarte

    2010-12-01

    Full Text Available Se describe la dinámica temporal de la vegetación de Mendoza mediante análisis de la fenología foliar regional con una serie de 108 imágenes mensuales de índice de vegetación NOAA-AVHRR NDVI GAC. La serie se descompone aplicando la Transformada Rápida de Fourier en parámetros dinámicos: NDVI medio, amplitudes (máxima variabilidad del NDVI y fases (tiempo entre inicio del ciclo y máximo NDVI para diferentes períodos. Con los parámetros con mayor información (variablilidad inter e intraanual se hace una clasificación y se obtiene un mapa de 18 áreas de comportamiento fenológico. Éste se vincula con los ecosistemas y con las unidades de vegetación. Se modela el patrón fenológico (curva NDVI mensual para 17 unidades de vegetación. El mapa aporta elementos dinámicos al estudio regional de la vegetación generando una zonificación nueva explicada por variables que determinan la actividad vegetativa. El patrón fenológico describe el funcionamiento de la vegetación y permite comprender sus variaciones geográficas. El conjunto de la vegetación de Mendoza responde a un ciclo anual con matices localizados de ligera bimodalidad. Los patrones de bajo contraste invierno-verano corresponden a condiciones climáticas xéricas expresando su máximo vegetativo al final del verano; la disponibilidad hídrica incrementa este contraste acortando el tiempo de máxima expresión vegetativa.The temporal dynamics of vegetation in Mendoza is described through analysis of regional foliar phenology using a series of 108 monthly NOAA-AVHRR NDVI GAC images. A Fast Fourier Transform was used to decompose the series into dynamic parameters: mean NDVI, amplitudes (maximum NDVI variability and phases (time from start of cycle to maximum NDVI for different time periods. A classification is made based on those parameters with larger information content (inter- and intra-annual variability, achieving a map of 18 areas of phenological behaviour. This

  6. 灰色预测GM(1,1)模型的Matlab实现%Matlab realization of grey prediction GM (1,1) model

    Institute of Scientific and Technical Information of China (English)

    朱登远; 常晓凤

    2013-01-01

    介绍了GM(1,1)模型的基本原理和建模步骤,利用Matlab实现了程序化、智能化的灰色预测GM(1,1)模型.通过实例验证了其能够快速、精确地进行计算,可以帮助工程人员对所得数据进行准确性分析和预测.

  7. Moon night sky brightness simulation for the Xinglong station

    International Nuclear Information System (INIS)

    Using a sky brightness monitor at the Xinglong station of National Astronomical Observatories, Chinese Academy of Sciences, we collected data from 22 dark clear nights and 90 moon nights. We first measured the sky brightness variation with time for dark nights and found a clear correlation between sky brightness and human activity. Then with a modified sky brightness model of moon nights and data from these nights, we derived the typical value for several important parameters in the model. With these results, we calculated the sky brightness distribution under a given moon condition for the Xinglong station. Furthermore, we simulated the sky brightness distribution of a moon night for a telescope with a 5° field of view (such as LAMOST). These simulations will be helpful for determining the limiting magnitude and exposure time, as well as planning the survey for LAMOST during moon nights

  8. Xenolitos ultramáficos en el cerro De la Laguna, volcanismo basáltico de retroarco en el sureste de la provincia de Mendoza, Argentina Ultramafic xenoliths in De la Laguna hill, retro-arc basaltic volcanism in the southeast of Mendoza Province, Argentina

    Directory of Open Access Journals (Sweden)

    G. W. Bertotto

    2002-12-01

    Full Text Available Se describen por primera vez xenolitos ultramáficos incluidos en basaltos de retroarco cenozoicos, en el sector extraandino de la provincia de Mendoza. El basalto portador tiene estructura masiva y textura porfírica con asociaciones de fenocristales de olivino-clinopiroxeno y olivino-plagioclasa. Todos los xenolitos ultramáficos son peridotitas en facies de espinela, se reconocieron lherzolitas, wehrlitas y dunitas, en orden de abundancia. Presentan una asociación mineral compuesta por olivino, ortopiroxeno, clinopiroxeno y espinela. Las texturas identificadas son porfiroclástica de Tipo I y porfiroclástica a equigranular de Tipo I. Estos xenolitos tienen zonas de reacción microscópicas mayormente desarrolladas en los ortopiroxenos y clinopiroxenos en el contacto con el basalto. La presencia de reacción indica al menos un evento de desequilibrio. Estas peridotitas representan fragmentos del manto superior situado debajo de la zona estudiada.Ultramafic xenoliths in Cenozoic retro-arc basalts of the extra-Andean sector of Mendoza province are described here for the first time. The host basalt has a massive structure and porphyritic texture with phenocryst assemblages of olivine-clinopyroxene and olivine-plagioclase. All the ultramafic xenoliths are spinel-bearing peridotites; lherzolite, wehrlite and dunite, in order of abundance, have been recognized. The mineral assemblage is olivine-orthopyroxene-clinopyroxene-spinel. Textures are porphyroclastic Type I and porphyroclastic to equigranular Type I. The xenoliths contain microscopic reaction areas, mainly developed in orthopyroxene and clinopyroxene in the contact with basalt. The reaction indicates at least one disequilibrium event. The peridotites are fragments of the upper mantle situated beneath the study area.

  9. Monitoring the prevalence of genetically modified (GM) maize in commercial animal feeds and food products in Turkey

    OpenAIRE

    Türkeç, Aydın; Turkec, Aydin; Stuart J Lucas; Karlık, Elif; Karlik, Elif

    2015-01-01

    BACKGROUND: EU legislation strictly controls use of genetically modified (GM) crops in food and feed products, and requires them to be labelled if the total GM content is greater than 9 g.kg-1 (for approved GM crops). We screened maize-containing food and feed products from Turkey to assess the prevalence of GM material. RESULTS: With this aim, 83 food and feed products – none labelled as containing GM material – were screened using multiplex real-time polymerase chain reaction (PCR) f...

  10. Pili Binding to Asialo-GM1 on Epithelial Cells Can Mediate Cytotoxicity or Bacterial Internalization by Pseudomonas aeruginosa

    OpenAIRE

    Comolli, James C; Waite, Leslie L.; Keith E Mostov; Joanne N. Engel

    1999-01-01

    The interaction of Pseudomonas aeruginosa type IV pili and the glycosphingolipid asialo-GM1 (aGM1) can mediate bacterial adherence to epithelial cells, but the steps subsequent to this adherence have not been elucidated. To investigate the result of the interaction of pili and aGM1, we used polarized epithelial monolayers of Madin-Darby canine kidney (MDCK) cells in culture, which contained little detectable aGM1 on their apical surface but were able to incorporate exogenous aGM1. Compared to...

  11. Annular bright and dark field imaging of soft materials

    International Nuclear Information System (INIS)

    Here polyethylene, as an example of an important soft material, was studied by STEM annular bright and dark field. The contrast as function of the probe size/shape and the detector collection angle are discussed. The results are compared to conventional bright field transmission electron microscopy, electron energy filtered imaging and energy dispersive spectroscopy mapping. Annular bright and dark field gave a higher contrast than conventional transmission and analytical mapping techniques

  12. Variability, Brightness Temperature, Superluminal Motion, Doppler Boosting, and Related Issues

    CERN Document Server

    Kellermann, K I

    2003-01-01

    We review the observations of rapid flux density variations in compact radio sources, and discuss the inverse Compton limit to the maximum brightness temperature of incoherent synchrotron sources in comparison with recent VLBA observations. The apparent agreement of the theoretical brightness temperature limit due to inverse Compton cooling and the brightness temperatures observed by early VLBI observations appears to have been fortuitous. VLBA observations have greatly improved the quality of the data, but many of the early issues remain unresolved.

  13. Research on Brightness Measurement of Intense Electron Beam

    CERN Document Server

    Wang, Yuan; Zhang, Huang; Yang, GuoJun; Li, YiDing; Li, Jin

    2015-01-01

    The mostly research fasten on high emission density of injector to study electron beam's brightness in LIA. Using the injector(2MeV) was built to research brightness of multi-pulsed high current(KA) electron beam, and researchs three measurement method (the pepper-pot method, beam collimator without magnetic field, beam collimator with magnetic field method) to detect beam's brightness with time-resolved measurement system.

  14. Assessment of the safety of foods derived from genetically modified (GM) crops

    DEFF Research Database (Denmark)

    Konig, A.; Cockburn, A.; Crewel, R. W. R.;

    2004-01-01

    This paper provides guidance on how to assess the safety of foods derived from genetically modified crops (GM crops); it summarises conclusions and recommendations of Working Group I of the ENTRANSFOOD project. The paper provides an approach for adapting the test strategy to the characteristics...... of the modified crop and the introduced trait, and assessing potential unintended effects from the genetic modification. The proposed approach to safety assessment starts with the comparison of the new GM crop with a traditional counterpart that is generally accepted as safe based on a history of human food use...... (the concept of substantial equivalence). This case-focused approach ensures that foods derived from GM crops that have passed this extensive test-regime are as safe and nutritious as currently consumed plant-derived foods. The approach is suitable for current and future GM crops with more complex...

  15. ICD-10-GM 2008: DIMDI veröffentlicht die endgültige Fassung

    OpenAIRE

    DIMDI-Pressestelle

    2007-01-01

    Das DIMDI hat die endgültige Fassung der ICD-10-GM Version 2008 (Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme, German Modification) auf seinen Internetseiten veröffentlicht.

  16. Stability of GM(1,1) power model on vector transformation

    Institute of Scientific and Technical Information of China (English)

    Jinhai Guo; Xinping Xiao; Jun Liu; Shu hua Mao

    2015-01-01

    The morbidity problem of the GM(1,1) power model in parameter identification is discussed by using multiple and rota-tion transformation of vectors. Firstly we consider the morbidity problem of the special matrix and prove that the condition num-ber of the coefficient matrix is determined by the ratio of lengths and the included angle of the column vector, which could be ad-justed by multiple and rotation transformation to turn the matrix to a wel-conditioned one. Then partition the corresponding matrix of the GM(1,1) power model in accordance with the column vector and regulate the matrix to a wel-conditioned one by multiple and rotation transformation of vectors, which completely solve the in-stability problem of the GM(1,1) power model. Numerical results show that vector transformation is a new method in studying the stability problem of the GM(1,1) power model.

  17. Africa's inevitable walk to genetically modified (GM) crops: opportunities and challenges for commercialization.

    Science.gov (United States)

    Okeno, James A; Wolt, Jeffrey D; Misra, Manjit K; Rodriguez, Lulu

    2013-01-25

    High relative poverty levels in Africa are attributed to the continent's under performing agriculture. Drought, low-yielding crop varieties, pests and diseases, poor soils, low fertilizer use, limited irrigation and lack of modern technologies are among the problems that plague African agriculture. Genetically modified (GM) crops may possess attributes that can help overcome some of these constraints, but have yet to be fully embraced in the mix of technology solutions for African agriculture. Cognizant of this, South Africa, Burkina Faso and Egypt are steadily growing GM crops on a commercial scale. Countries like Kenya, Nigeria, and Uganda are increasingly field-testing these crops with the view to commercialize them. These countries show strong government support for GM technology. Progress by these first adopter nations provides an insight as to how GM crops are increasingly being viewed as one of the ways in which the continent can invigorate the agriculture sector and achieve food security. PMID:22985799

  18. INVESTIGATION ON THE CAUSES OF EUCALYPTUS KRAFT PULP BRIGHTNESS REVERSION

    OpenAIRE

    Kátia M. M. Eiras; Jorge Luiz Colodette; Ana Márcia M. L. Carvalho

    2005-01-01

    Some high brightness eucalyptus Kraft pulps have shown poor brightness stability. In most cases, the causes have notbeen identified and permanent solutions have not been found. This work focused on evaluating the brightness stability profile of pulpsbleached by in sequences such as O(DC)(PO)DD, O(DC)(PO)DP, OD(PO)DD, OD(PO)DP, ODHT(PO)DD, ODHT(PO)DP, OA/D(PO)DD, OA/D(PO)DP, OAD(PO)DD and O(Ze)D(PO). Brightness stability tests induced by according to Tappi UM200 procedureon samples bleached to...

  19. Consumer Acceptance of GM Applications in the Pork Production Chain: A Choice Modelling Approach

    OpenAIRE

    Novoselova, Tatiana A.; van der Lans, Ivo A.C.M.; Meuwissen, Miranda P.M.; Huirne, Ruud B.M.

    2005-01-01

    This study evaluates consumer acceptance of different GM applications in the pork production chain. In general, results indicate that consumers prefer conventional pork over pork for which genetic modification was applied. However, the negative impact of the GM applications is compensated by improvements in quality, increased animal welfare, a lower impact on the environment, less residues and a price discount. Of these benefits, increased animal welfare has the most positive effect on consum...

  20. Food safety and GM crops implications for developing-country research

    OpenAIRE

    Cohen, Joel I.; Quemada, Hector; Frederick, Robert

    2003-01-01

    "In the developing world the approval and cultivation of genetically modified (GM) crops is largely limited to the commercial production of insect-resistant cotton in Argentina, China, India, Mexico, and South Africa.... Approvals of GM crops used for food or feed lag far behind cotton... This gap in approvals is unfortunate, because crop biotechnology, appropriately applied, has the potential to address key production constraints affecting resource-poor farmers. Currently, important public- ...

  1. Response to issues on GM agriculture in Africa: Are transgenic crops safe?

    OpenAIRE

    Adenle Ademola A

    2011-01-01

    Abstract The controversies surrounding transgenic crops, often called Genetically Modified Organisms (GMOs), call for a need to raise the level of public awareness of Genetic Modification (GM) technology in Africa. This should be accomplished by educating the public about the potential benefits and risks that may be associated with this new technology. In the last 15 years, GM crop producing countries have benefited from adoption of this new technology in the form of improved crop productivit...

  2. Who benefits from gm crops? Feeding the biotech giants, not the world's poor

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Villar, J.; Freese, B.; Holder, H.; Chandrasekaran, K.; Rodriguez, L.

    2009-02-15

    The biotechnology industry has aggressively touted GM as a solution to hunger and the global food crisis. Their arguments have been accepted by many politicians. This Friends of the Earth International (FoEI) report looks behind the spin and exposes the reasons why GM crops cannot, and are unlikely to ever, contribute to poverty reduction, global food security or sustainable farming (authors' abstract)

  3. Development of a dry linear compressor for GM and pulse tube cryocoolers

    CERN Document Server

    Höhne, Jens

    2015-01-01

    Pressure Wave Systems GmbH has developed a dry compressor for GM and pulse tube cryocoolers. The concept is based on hydraulically driven metal bellows in which the Helium working gas is compressed. The system is operated in the region of 1 kW of electrical input power and has been successfully tested with a SHI RDK-101D GM cryocooler cold head. Set-up, performance and reliability of the compressor system will be discussed.

  4. Development of a dry linear compressor for GM and pulse tube cryocoolers

    Science.gov (United States)

    Hoehne, J.

    2015-12-01

    Pressure Wave Systems GmbH has developed a dry compressor for GM and pulse tube cryocoolers. The concept is based on hydraulically driven metal bellows in which the Helium working gas is compressed. The system is operated in the region of 1 kW of electrical input power and has been successfully tested with a SHI RDK-101D GM cryocooler cold head. Set-up, performance and reliability of the compressor system will be discussed.

  5. Overexpression of Soybean Isoflavone Reductase (GmIFR) Enhances Resistance to Phytophthora sojae in Soybean

    OpenAIRE

    Cheng, Qun; Li, Ninghui; Dong, Lidong; Zhang, Dayong; Fan, Sujie; Jiang, Liangyu; Wang, Xin; Xu, Pengfei; Zhang, Shuzhen

    2015-01-01

    Isoflavone reductase (IFR) is an enzyme involved in the biosynthetic pathway of isoflavonoid phytoalexin in plants. IFRs are unique to the plant kingdom and are considered to have crucial roles in plant response to various biotic and abiotic environmental stresses. Here, we report the characterization of a novel member of the soybean isoflavone reductase gene family GmIFR. Overexpression of GmIFR transgenic soybean exhibited enhanced resistance to Phytophthora sojae. Following stress treatmen...

  6. An Experimental Investigation of Willingness to Pay for Non-GM and Organic Food Products

    OpenAIRE

    Gifford, Katie; Bernard, John C.; Toensmeyer, Ulrich C.; Bacon, J. Richard

    2005-01-01

    The appearance and rapid adoption of genetically modified (GM) foods and the strong growth in organic foods are two of the major trends that have influenced the food system over the past several years. The purpose of this research was to determine consumer willingness to pay (WTP) for non-GM and organic foods relative to conventional foods and to see if WTP differences between the three categories vary between fresh and processed food products. Experimental auctions with 133 subjects from thr...

  7. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages

    OpenAIRE

    Trapnell, Bruce C.; Carey, Brenna C.; Uchida, Kanji; Suzuki, Takuji

    2009-01-01

    Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation of pulmonary surfactant, respiratory insufficiency, and increased infections. It occurs in various clinical settings that disrupt surfactant catabolism in alveolar macrophages, including a relatively more common autoimmune disease caused by GM-CSF autoantibodies and a rare congenital disease caused by CSF2RA mutations. Recent results demonstrate that GM-CSF is critical for alveolar macrophage terminal differ...

  8. GM-CSF Differentially Regulates Eosinophil and Neutrophil Adhesive Interactions with Vascular Endothelium in Vivo

    Directory of Open Access Journals (Sweden)

    Nooshin Sheikh Bahaie

    2010-12-01

    Full Text Available Allergic airway inflammation is characterized by elaboration of cytokines and chemokines leading to recruitment of inflammatory leukocytes, predominantly eosinophils, to the airways. Granulocyte macrophage colony stimulating factor (GM-CSF is generated in the lungs of human subjects with asthma in response to allergen challenge and is necessary for the development of allergen-induced bronchial eosinophilia in mice. The effect of GM-CSF on human eosinophil and neutrophil interactions with the vascular endothelium under conditions of blood flow was investigated in post-capillary venules of the rabbit mesentery by intravital microscopy.While GM-CSF significantly reduced the rolling fraction of neutrophils in vivo and induced consistent shedding of neutrophil L-selectin in vitro, its effect on eosinophil rolling was variable. Eosinophils from 57% of the donors demonstrated inhibition of rolling, while eosinophils from the remaining 43% of donors demonstrated no inhibition or increased rolling. The variable effect of GM-CSF on inhibition of eosinophil rolling was associated with variable shedding of L-selectin in vitro. In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF. Overall, these studies demonstrate that GM-CSF consistently inhibits interaction of neutrophils with endothelium in vivo, whereas its effect on eosinophil-endothelial interactions is variable. GM-CSF may thus be one factor accounting for the varying percentage of eosinophils and neutrophils recruited to sites of allergic inflammation in different individuals.

  9. Some Implications of GM Food Technology Policies for Sub-Saharan Africa

    OpenAIRE

    Kym Anderson; Lee Ann Jacskon

    2004-01-01

    The first generation of genetically modified (GM) crop varieties sought to increase farmer profitability through cost reductions or higher yields. The next generation of GM food research is focusing also on breeding for attributes of interest to consumers, beginning with ‘golden rice’, which has been genetically engineered to contain a higher level of vitamin A and thereby boost the health of unskilled labourers in developing countries. This paper analyses empirically the potential economic...

  10. Functional analysis of GmCPDs and investigation of their roles in flowering.

    Directory of Open Access Journals (Sweden)

    Miao Wang

    Full Text Available The onset of floral development is a pivotal switch in the life of soybean. Brassinosteroids (BRs, a group of steroidal phytohormones with essential roles in plant growth and development, are associated with flowering induction. Genes involved in BR biosynthesis have been studied to a great extent in Arabidopsis, but the study of these genes has been limited in soybean. In this study, four CPD homologs (GmCPDs catalyzing BR synthesis were isolated from soybean. Transcripts were mainly confined to cotyledons and leaves and were down-regulated in response to exogenous BR. Bioinformatic analysis showed strong sequence and structure similarity between GmCPDs and AtCPD as well as CPDs of other species. Overexpression of GmCPDs in an Arabidopsis BR-deficient mutant rescued the phenotype by restoring the biosynthesis pathway, revealing the functional roles of each GmCPDs in. Except for the rescue of root development, leaf expansion and plant type architecture, GmCPDs in expression also complemented the late flowering phenotype of Arabidopsis mutants deficient in CPD. Further evidence in soybean plants is that the expression levels of GmCPDs in are under photoperiod control in Zigongdongdou, a photoperiod-sensitive variety, and show a sudden peak upon floral meristem initiation. Together with increased GmCPDs in expression in the leaves and cotyledons of photoperiod-insensitive early-maturity soybean, it is clear that GmCPDs in contribute to flowering development and are essential in the early stages of flowering regulation.

  11. GLTP Mediated Non-Vesicular GM1 Transport between Native Membranes

    OpenAIRE

    Lauria, Ines; van Üüm, Jan; Mjumjunov-Crncevic, Esmina; Walrafen, David; Spitta, Luis; Thiele, Christoph; Lang, Thorsten

    2013-01-01

    Lipid transfer proteins (LTPs) are emerging as key players in lipid homeostasis by mediating non-vesicular transport steps between two membrane surfaces. Little is known about the driving force that governs the direction of transport in cells. Using the soluble LTP glycolipid transfer protein (GLTP), we examined GM1 (monosialotetrahexosyl-ganglioside) transfer to native membrane surfaces. With artificial GM1 donor liposomes, GLTP can be used to increase glycolipid levels over natural levels i...

  12. Risk perceptions, risk attitudes and the formation of consumer acceptance of Genetically Modified (GM) food

    OpenAIRE

    Costa Font, Montserrat; Gil Roig, José María

    2009-01-01

    The influence of risk perception and risk attitudes in the process of accepting genetically modified (GM) food is often ignored, and particularly whether both constructs (latent variables) have a combined effect in explaining consumer acceptance. Similarly, the inclusion of organic product standards juxtaposed to GM food is unknown. This paper attempts to shed some light on this question by examining the decision making process through the use of structural equation modeling (SEM). We use sur...

  13. Differences in WTP and Consumer Demand for Organic and Non-GM Fresh and Processed Foods

    OpenAIRE

    He, Na; Bernard, John C.

    2011-01-01

    Auction experiments were used to examine demand and premium differences between organic, non-GM (genetically modified), and conventional versions for two pairs of fresh and processed foods. Results showed processed foods had greater substitutability among the versions than fresh products. Conventional versions were the least price sensitive, while non-GM versions were the most sensitive. Significant premium differences were found between fresh and processed foods for sweet corn and tortilla c...

  14. Comprehensive Analysis of the Soybean (Glycine max) GmLAX Auxin Transporter Gene Family.

    Science.gov (United States)

    Chai, Chenglin; Wang, Yongqin; Valliyodan, Babu; Nguyen, Henry T

    2016-01-01

    The phytohormone auxin plays a critical role in regulation of plant growth and development as well as plant responses to abiotic stresses. This is mainly achieved through its uneven distribution in plant via a polar auxin transport process. Auxin transporters are major players in polar auxin transport. The AUXIN RESISTENT 1/LIKE AUX1 (AUX/LAX) auxin influx carriers belong to the amino acid permease family of proton-driven transporters and function in the uptake of indole-3-acetic acid (IAA). In this study, genome-wide comprehensive analysis of the soybean AUX/LAX (GmLAX) gene family, including phylogenic relationships, chromosome localization, and gene structure, was carried out. A total of 15 GmLAX genes, including seven duplicated gene pairs, were identified in the soybean genome. They were distributed on 10 chromosomes. Despite their higher percentage identities at the protein level, GmLAXs exhibited versatile tissue-specific expression patterns, indicating coordinated functioning during plant growth and development. Most GmLAXs were responsive to drought and dehydration stresses and auxin and abscisic acid (ABA) stimuli, in a tissue- and/or time point- sensitive mode. Several GmLAX members were involved in responding to salt stress. Sequence analysis revealed that promoters of GmLAXs contained different combinations of stress-related cis-regulatory elements. These studies suggest that the soybean GmLAXs were under control of a very complex regulatory network, responding to various internal and external signals. This study helps to identity candidate GmLAXs for further analysis of their roles in soybean development and adaption to adverse environments. PMID:27014306

  15. Comprehensive analysis of the soybean (Glycine max GmLAX auxin transporter gene family

    Directory of Open Access Journals (Sweden)

    Chenglin eChai

    2016-03-01

    Full Text Available The phytohormone auxin plays a critical role in regulation of plant growth and development as well as plant responses to abiotic stresses. This is mainly achieved through its uneven distribution in plants via a polar auxin transport process. Auxin transporters are major players in polar auxin transport. The AUXIN RESISTANT 1 ⁄ LIKE AUX1 (AUX⁄LAX auxin influx carriers belong to the amino acid permease family of proton-driven transporters and function in the uptake of indole-3-acetic acid (IAA. In this study, genome-wide comprehensive analysis of the soybean AUX⁄LAX (GmLAX gene family, including phylogenic relationships, chromosome localization, and gene structure, were carried out. A total of 15 GmLAX genes, including seven duplicated gene pairs, were identified in the soybean genome. They were distributed on 10 chromosomes. Despite their higher percentage identities at the protein level, GmLAXs exhibited versatile tissue-specific expression patterns, indicating coordinated functioning during plant growth and development. Most GmLAXs were responsive to drought and dehydration stresses and auxin and abscisic acid (ABA stimuli, in a tissue- and/or time point- sensitive mode. Several GmLAX members were involved in responding to salt stress. Sequence analysis revealed that promoters of GmLAXs contained different combinations of stress-related cis-regulatory elements. These studies suggest that the soybean GmLAXs were under control of a very complex regulatory network, responding to various internal and external signals. This study helps to identity candidate GmLAXs for further analysis of their roles in soybean development and adaption to adverse environments.

  16. Market Power of the Japanese Non-GM Soybean Import Market: The U.S. Exporters VS. Japanese Importers

    Directory of Open Access Journals (Sweden)

    Koichi Yamaura

    2011-12-01

    Full Text Available Genetically modified (GM soybean acreage has rapidly increased in the world in the past decade and globally the majority of countries now use GM soybeans to produce oil and meal for livestock and human consumption. Japan, however, uses only Non-GM soybeans as widely recognized high quality goods in vertically differentiated import soybeans in Japan, for direct human consumption of which more than 80% are imported from the U.S., Canada, and China. This research used the inverse residual demand model to estimate a U.S.-Japan partial equilibrium trade model to test the existence of market power in the Japanese Non-GM soybean import market. The U.S.-Japan partial equilibrium trade model incorporated the U.S. residual Non-GM soybean supply for Japan, the Japanese residual demand for U.S. Non-GM soybeans, and the equilibrium condition, where the U.S. residual Non-GM soybean supply equals the Japanese residual Non-GM soybean demand. Monthly data from January 2003 to December 2007 were used for the analysis. Empirical results indicated that U.S. Non-GM soybean exporters have stronger market power than Japanese Non-GM soybean importers. The results are different from other countries empirical studies and indicate that Japanese consumers are willing to pay higher prices for soybeans, tofu, natto, miso, and other all soy food products using Non-GM soybeans.

  17. Market Power of The Japanese Non-GM Soybean Import Market: The U.S. Exporters vs. Japanese Importers

    Directory of Open Access Journals (Sweden)

    Koichi Yamaura

    2011-12-01

    Full Text Available Genetically modified (GM soybean acreage has rapidly increased in the world in the past decade and globally the majority of countries now use GM soybeans to produce oil and meal for livestock and human consumption. Japan,however, uses only Non-GM soybeans as widely recognized high quality goods in vertically differentiated import soybeans in Japan, for direct human consumption of which more than 80% are imported from the U.S., Canada, and China. This research used the inverse residual demand model to estimate a U.S.-Japan partial equilibrium trade model to test the existence of market power in the Japanese Non-GM soybean import market. The U.S.-Japan partial equilibrium trade model incorporated the U.S. residual Non-GM soybeansupply for Japan, the Japanese residual demand for U.S. Non-GM soybeans, and the equilibrium condition, where the U.S. residual Non-GM soybean supply equals the Japanese residual Non-GM soybean demand. Monthly data from January 2003 to December 2007 were used for the analysis. Empirical results indicated that U.S. Non-GM soybean exporters have stronger market power than Japanese Non-GM soybean importers. The results are different from other countries empirical studies and indicate that Japanese consumers are willing to pay higher prices for soybeans, tofu, natto, miso, and other all soy food products using Non-GM soybeans.

  18. Modeling gene flow distribution within conventional fields and development of a simplified sampling method to quantify adventitious GM contents in maize.

    Science.gov (United States)

    Melé, Enric; Nadal, Anna; Messeguer, Joaquima; Melé-Messeguer, Marina; Palaudelmàs, Montserrat; Peñas, Gisela; Piferrer, Xavier; Capellades, Gemma; Serra, Joan; Pla, Maria

    2015-01-01

    Genetically modified (GM) crops have been commercially grown for two decades. GM maize is one of 3 species with the highest acreage and specific events. Many countries established a mandatory labeling of products containing GM material, with thresholds for adventitious presence, to support consumers' freedom of choice. In consequence, coexistence systems need to be introduced to facilitate commercial culture of GM and non-GM crops in the same agricultural area. On modeling adventitious GM cross-pollination distribution within maize fields, we deduced a simple equation to estimate overall GM contents (%GM) of conventional fields, irrespective of its shape and size, and with no previous information on possible GM pollen donor fields. A sampling strategy was designed and experimentally validated in 19 agricultural fields. With 9 samples, %GM quantification requires just one analytical GM determination while identification of the pollen source needs 9 additional analyses. A decision support tool is provided. PMID:26596213

  19. Acquirement and characterization of a carotenoid mutant (GM309) of Rhodobacter sphaeroides 601

    Institute of Scientific and Technical Information of China (English)

    LIU Yuan; ZHANG Wei; WU Yongqiang; XU Chunhe

    2004-01-01

    A green mutant was obtained among the chemically induced mutants of Rhodobacter sphaeroides 601 (RS601) and named GM309. A blue shift of 20 nm of the carotenoid absorption spectrum was found in the light-harvesting complex II (LH2) of GM309. Different from LH2 of RS601, it was found that the carotenoids in GM309-LH2 changed to be neurosporene by mutation. Neurosporene lacks a conjugate double bond, compared with the spheroidene in RS601-LH2 which has ten conjugate double bonds. As shown by absorption and circular dichroism spectroscopy, the overall structure of GM309-LH2 is little affected by this change. From fluorescence emission spectra, it is found that GM309-LH2 can transfer energy from carotenoids to Bchl-B850 without any change in efficiency. But the efficiency of energy transfer from B800 to B850 in GM309-LH2 is decreased to be 42% of that of the native. This work would provide a novel method to investigate the mechanism of excitation energy transfer in LH2.

  20. Health effect of agricultural pesticide use in China: implications for the development of GM crops

    Science.gov (United States)

    Zhang, Chao; Hu, Ruifa; Huang, Jikun; Huang, Xusheng; Shi, Guanming; Li, Yifan; Yin, Yanhong; Chen, Zhaohui

    2016-01-01

    It is notable that the adoption of GM glyphosate-tolerant crops increases glyphosate use but reduces non-glyphosate herbicide use; and adoption of GM insect-resistant crops significantly reduces insecticide use. While the health hazard of pesticide use has been well documented, little literature evaluates the health effects of different pesticides related to GM crops in an integrated framework. This study aims to associate the uses of different pesticides related to GM crops with the blood chemistry panel and peripheral nerve conduction of Chinese farmers. Pesticides used by farmers were recorded and classified as glyphosate, non-glyphosate herbicides, chemical lepidopteran insecticides, biological lepidopteran insecticides, non-lepidopteran insecticides and fungicides. The multivariate regression results show that none of the examined 35 health indicators was associated with glyphosate use, while the use of non-glyphosate herbicides was likely to induce renal dysfunction and decrease of serum folic acid. The use of chemical lepidopteran insecticides might be associated with hepatic dysfunction, serum glucose elevation, inflammation and even severe nerve damage. In this context, if GM crops are adopted, the alterations in pesticide use may benefit farmer health in China and globe, which has positive implications for the development of GM crops. PMID:27721390

  1. MafB antagonizes phenotypic alteration induced by GM-CSF in microglia.

    Science.gov (United States)

    Koshida, Ryusuke; Oishi, Hisashi; Hamada, Michito; Takahashi, Satoru

    Microglia are tissue-resident macrophages which are distributed throughout the central nervous system (CNS). Recent studies suggest that microglia are a unique myeloid population distinct from peripheral macrophages in terms of origin and gene expression signature. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a pleiotropic cytokine regulating myeloid development, has been shown to stimulate proliferation and alter phenotype of microglia in vitro. However, how its signaling is modulated in microglia is poorly characterized. MafB, a bZip transcriptional factor, is highly expressed in monocyte-macrophage lineage cells including microglia, although its role in microglia is largely unknown. We investigated the crosstalk between GM-CSF signaling and MafB by analyzing primary microglia. We found that Mafb-deficient microglia grew more rapidly than wild-type microglia in response to GM-CSF. Moreover, the expression of genes associated with microglial differentiation was more downregulated in Mafb-deficient microglia cultured with GM-CSF. Notably, such differences between the genotypes were not observed in the presence of M-CSF. In addition, we found that Mafb-deficient microglia cultured with GM-CSF barely extended their membrane protrusions, probably due to abnormal activation of RhoA, a key regulator of cytoskeletal remodeling. Altogether, our study reveals that MafB is a negative regulator of GM-CSF signaling in microglia. These findings could provide new insight into the modulation of cytokine signaling by transcription factors in microglia.

  2. GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice.

    Science.gov (United States)

    Ni, Yu-Fei; Zhang, Wei; Bao, Xiao-Feng; Wang, Wei; Song, Lu; Jiang, Bo

    2016-08-01

    Cognitive deficits are core symptoms of schizophrenia, but effective treatments are still lacking. Previous studies have reported that the brain-derived neurotrophic factor (BDNF) signaling is closely involved in learning and memory. Monosialotetrahexosylganglioside (GM1) is a ganglioside with wide-ranging pharmacologic effects that enhances the BDNF signaling cascade. This study aimed to assess the effects of GM1 on schizophrenia-related cognitive impairments. A brief disruption of N-methyl-D-aspartate receptors with MK801 was used to generate the animal model for cognitive deficits in schizophrenia. It was found that MK801-treated mice showed significant deficits in memory ability compared with control mice in different behavior tests, and this was accompanied by decreased hippocampal BDNF signaling pathway. Consecutive administration of GM1 fully restored the MK801-induced cognitive deficits and the impaired BDNF signaling in the hippocampus. Furthermore, a BDNF system inhibitor abolished the effects of GM1 in the MK801 model. Taken together, our results show that GM1 could reverse the MK801-induced cognitive deficits, suggesting a potential usefulness of GM1 in treating the schizophrenia-related cognitive impairments. PMID:26960162

  3. Social Impacts of GM Crops in Agriculture: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Klara Fischer

    2015-07-01

    Full Text Available It has recently been argued that the fragmented knowledge on the social impacts of genetically modified (GM crops is contributing to the polarised debate on the matter. This paper addresses this issue by systematically reviewing 99 peer-reviewed journal articles published since 2004 on the social impacts of GM crops in agriculture; summarising current knowledge, and identifying research gaps. Economic impact studies currently dominate the literature and mainly report that GM crops provide economic benefits for farmers. Other social impacts are less well studied, but present a more complex picture. Studies on access to and benefits of GM crops show that these vary significantly depending on the political and regulatory setting. Substantial evidence indicates that intellectual property rights (IPR and the private industry’s dominance limit the access and utility of available GM crops to many farmers. Wellbeing is frequently discussed in the literature, but rarely investigated empirically. Existing evidence is contradictory and inconclusive. Impact studies from the Global North are virtually non-existent. Moreover, two-thirds of publications are based on previously published empirical evidence, indicating a need for new empirical investigations into the social impacts of GM crops in agriculture.

  4. Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.

    Science.gov (United States)

    Kitakaze, Keisuke; Mizutani, Yasumichi; Sugiyama, Eiji; Tasaki, Chikako; Tsuji, Daisuke; Maita, Nobuo; Hirokawa, Takatsugu; Asanuma, Daisuke; Kamiya, Mako; Sato, Kohei; Setou, Mitsutoshi; Urano, Yasuteru; Togawa, Tadayasu; Otaka, Akira; Sakuraba, Hitoshi; Itoh, Kohji

    2016-05-01

    GM2 gangliosidoses, including Tay-Sachs and Sandhoff diseases, are neurodegenerative lysosomal storage diseases that are caused by deficiency of β-hexosaminidase A, which comprises an αβ heterodimer. There are no effective treatments for these diseases; however, various strategies aimed at restoring β-hexosaminidase A have been explored. Here, we produced a modified human hexosaminidase subunit β (HexB), which we have termed mod2B, composed of homodimeric β subunits that contain amino acid sequences from the α subunit that confer GM2 ganglioside-degrading activity and protease resistance. We also developed fluorescent probes that allow visualization of endocytosis of mod2B via mannose 6-phosphate receptors and delivery of mod2B to lysosomes in GM2 gangliosidosis models. In addition, we applied imaging mass spectrometry to monitor efficacy of this approach in Sandhoff disease model mice. Following i.c.v. administration, mod2B was widely distributed and reduced accumulation of GM2, asialo-GM2, and bis(monoacylglycero)phosphate in brain regions including the hypothalamus, hippocampus, and cerebellum. Moreover, mod2B administration markedly improved motor dysfunction and a prolonged lifespan in Sandhoff disease mice. Together, the results of our study indicate that mod2B has potential for intracerebrospinal fluid enzyme replacement therapy and should be further explored as a gene therapy for GM2 gangliosidoses. PMID:27018595

  5. GmCLC1 Confers Enhanced Salt Tolerance through Regulating Chloride Accumulation in Soybean.

    Science.gov (United States)

    Wei, Peipei; Wang, Longchao; Liu, Ailin; Yu, Bingjun; Lam, Hon-Ming

    2016-01-01

    The family of chloride channel proteins that mediate Cl(-) transportation play vital roles in plant nutrient supply, cellular action potential and turgor pressure adjustment, stomatal movement, hormone signal recognition and transduction, Cl(-) homeostasis, and abiotic and biotic stress tolerance. The anionic toxicity, mainly caused by chloride ions (Cl(-)), on plants under salt stress remains poorly understood. In this work, we investigated the function of soybean Cl(-)/H(+) antiporter GmCLC1 under salt stress in transgenic Arabidopsis thaliana, soybean, and yeast. We found that GmCLC1 enhanced salt tolerance in transgenic A. thaliana by reducing the Cl(-) accumulation in shoots and hence released the negative impact of salt stress on plant growth. Overexpression of GmCLC1 in the hairy roots of soybean sequestered more Cl(-) in their roots and transferred less Cl(-) to their shoots, leading to lower relative electrolyte leakage values in the roots and leaves. When either the soybean GmCLC1 or the yeast chloride transporter gene, GEF1, was transformed into the yeast gef1 mutant, and then treated with different chloride salts (MnCl2, KCl, NaCl), enhanced survival rate was observed. The result indicates that GmCLC1 and GEF1 exerted similar effects on alleviating the stress of diverse chloride salts on the yeast gef1 mutant. Together, this work suggests a protective function of GmCLC1 under Cl(-) stress. PMID:27504114

  6. GM-CSF GENE OR B7-1 GENE MODIFIED MURINE EL-4 CELLS VACCINE

    Institute of Scientific and Technical Information of China (English)

    张清媛; 李殿俊; 王志华

    2001-01-01

    Objective: To study the vaccine potency of gene-modified tumor cells. Methods: The EL-4 lymphoma was transduced with recombinant retrovirus containing the murine GM-CSF gene or B7-1 gene. The effect of gene transduction on antitumor immunity was investigated. Results: Flow cytometry analysis showed that expression of their surface marker between wild-type EL-4 cells and gene transduced tumor cells was the same except for CD80 positive in B7-1 gene transduced cells. GM-CSF gene or B7-1 gene transduced EL-4 cells resulted in remarkable loss of tumorigenicity in syngenetic mice. The systemic protective immunity was induced against the challenge with EL-4/wt cells. Therapeutic vaccine with EL-4/GM-CSF or EL/7-1 cells could retard the growth of established early-stage EL-4/wt tumor significantly, but not retard the growth of late-stage EL-4/wt tumor. Irradiated GM-CSF gene transduced EL-4 cells showed strong vaccine effect against EL-4 cell challenge, but irradiated B7-1 gene transduced EL-4 cells showed weak vaccine effect. Remarkable cooperative antitumor effect against EL-4 cell challenge was observed when both irradiated EL-4/GM-CSF and EL-4/B7-1 were inoculated together. Conclusion: GM-CSF gene or B7-1 gene transduced combination of the two kinds of vaccine may have potential application value in human cancer treatment.

  7. Overexpression of soybean isoflavone reductase (GmIFR enhances resistance to Phytophthora sojae in soybean

    Directory of Open Access Journals (Sweden)

    Qun eCheng

    2015-11-01

    Full Text Available Isoflavone reductase (IFR is an enzyme involved in the biosynthetic pathway of isoflavonoid phytoalexin in plants. IFRs are unique to the plant kingdom and are considered to have crucial roles in plant response to various biotic and abiotic environmental stresses. Here, we report the characterization of a novel member of the soybean isoflavone reductase gene family GmIFR. The cDNA of GmIFR was 1199 bp containing a 939 bp open reading frame encoding a polypeptide of 312 amino acids. Sequence analysis suggested that GmIFR contained a NAD(P domain of 107 amino acids. Overexpression of GmIFR transgenic soybean exhibited enhanced resistance to Phytophthora sojae. Following stress treatments, GmIFR was significantly induced by P. sojae, ethephon (ET, abscisic acid (ABA, salicylic acid (SA. It is located in the cytoplasmic when transiently expressed in Arabidopsis protoplasts. The daidzein levels reduced greatly for the seeds of transgenic plants, while levels of genistein and glycitein had little change compared to that of control plants. Furthermore, we also found that the reactive oxygen species (ROS content of transgenic soybean plants was significantly lower than that of control plants, suggesting an important role of GmIFR might function as an antioxidant to reduce ROS in soybean.

  8. Análisis textural de cuarzo hidrotermal del depósito El Pantanito, provincia de Mendoza: Nuevos aportes sobre su génesis

    Directory of Open Access Journals (Sweden)

    N. Rubinstein

    2005-03-01

    Full Text Available El análisis textural del cuarzo hidrotermal del depósito El Pantanito, permitió realizar nuevos aportes sobre la génesis de esta mineralización epitermal de Au de baja sulfuración. Este depósito se localiza en el Bloque de San Rafael, provincia de Mendoza y está alojado en una secuencia volcánica permo-triásica, con características geoquímicas transicionales entre un régimen de subducción y uno de intraplaca continental. La ocurrencia conjunta de pseudomorfos de cuarzo según calcita, sílice coloforme - crustiforme y adularia, permite establecer que el nivel de erosión se encuentra dentro de la paleozona de ebullición ascendente. La superposición de texturas típicas de diferentes profundidades de formación, sugiere un proceso de tipo telescópico producido por la propagación, en profundidad, del frente de ebullición y por lo tanto de la zona de depositación de metales preciosos.

  9. Virulence profiles of Shiga toxin-producing Escherichia coli and other potentially diarrheagenic E.coli of bovine origin, in Mendoza, Argentina

    Directory of Open Access Journals (Sweden)

    M.A. Pizarro

    2013-12-01

    Full Text Available This study described a group of strains obtained from a slaughter house in Mendoza, in terms of their pathogenic factors, serotype, antibiotype and molecular profile. Ninety one rectal swabs and one hundred eight plating samples taken from carcasses of healthy cattle intended for meat consumption were analyzed. Both the swab and the plate samples were processed to analyze the samples for the presence of virulence genes by PCR: stx1, stx2, eae and astA. The Stx positive strains were confirmed by citotoxicity assay in Vero cells. The isolates were subsequently investigated for their O:H serotype, antimicrobial susceptibility and molecular profile by Random Amplification of Polymorphic DNA (RAPD. Twelve E.coli strains were identified by their pathogenicity. Nine were from fecal origin and three from carcasses. Three strains carried the stx1 gene, three the stx2 gene, two carried eae and four the astA gene. The detected serotypes were: O172:H-; O150:H8; O91:H21; O178:H19 and O2:H5. The strains showed a similarity around 70% by RAPD. Some of the E.coli strains belonged to serogroups known for certain life-threatening diseases in humans. Their presence in carcasses indicates the high probability of bacterial spread during slaughter and processing.

  10. Análisis de inclusiones fluidas en las vetas polimetálicas del pórfiro de Cu-(Mo San Pedro, Mendoza

    Directory of Open Access Journals (Sweden)

    Lidia I Korzeniewski

    2012-03-01

    Full Text Available El pórfiro de Cu-(Mo San Pedro, localizado en el cerro homónimo, se ubica en el sector sur del bloque de San Rafael, provincia de Mendoza. Comprende una zona de alteración, con mineralización diseminada, desarrollada en rocas volcánicas pertenecientes al Ciclo Magmático Choiyoi. En sus proximidades, aflora un conjunto de vetas polimetálicas las cuales, basándose en relaciones estratigráficas, han sido genéticamente relacionadas con el pórfiro. Estudios petrográficos y microtermométricos de inclusiones fluidas llevados a cabo en muestras de las vetas permiten confirmar dicha vinculación genética y establecer la existencia de dos etapas en la evolución del sistema hidrotermal. En la primera etapa participan fluidos magmáticos de elevada salinidad (37,5-41 % en peso equivalente NaCl y temperatura (356-389°C que dan origen a la alteración potásica y a la mineralización de Cu y en la segunda etapa participan fluidos magmáticos de bajas temperaturas (176-276°C y salinidades (0,35-8,68 % en peso equivalente NaCl los cuales dan lugar a la alteración fílica.

  11. Tipos de apoyo y la digitalización de las redes personales. El uso de Facebook de adolescentes rururbanos de Mendoza (Argentina

    Directory of Open Access Journals (Sweden)

    Alejandro Paredes

    2015-06-01

    Full Text Available El objetivo de este trabajo es analizar la red social virtual (en este caso Facebook de adolescentes que asisten a un colegio rururbano marginal de Mendoza (Argentina, y estudiar las percepciones que ellos manifiestan sobre los tipos de apoyo que les brinda. Se tomó a un curso del último año de una escuela secundaria compuesto por 23 alumnos de una edad promedio de 17 años (el 67% eran mujeres. En su mayoría provienen de familias cuyos padres no poseen ingresos estables. La metodología utilizada es la propia del análisis de redes sociales (realización de grafos con el software TouchGraph, análisis de centralidad, subgrupos y nodos de la red, aplicación de métodos estadísticos y metodología cualitativa (entrevistas individuales y Focus group. Con respecto al estudio de las redes personales a través del uso de Facebook, se apreció una masividad en el uso de esta red (solo dos casos no lo utilizan, no existiendo diferencias significativas según el género, en el número de amigos. Finalmente desde la percepción de los estudiantes, Facebook sirve para reforzar el apoyo informacional, tangible y afectivo, pero no tanto el apoyo axiológico.

  12. Assessing the solar potential of low-density urban environments in Andean cities with desert climates: The case of the city of Mendoza, in Argentina. 2nd. Part

    Energy Technology Data Exchange (ETDEWEB)

    Arboit, M.; Mesa, A.; Fernandez Llano, J.C.; de Rosa, C. [Instituto de Ciencias Humanas, Sociales y Ambientales. (INCIHUSA - CONICET), R+D Unit: Laboratorio de Ambiente Humano y Vivienda, Adrian Ruiz Leal s/n. Parque General San Martin. (5500) Mendoza (Argentina); Diblasi, A. [Facultad de Ciencias Economicas, UNCuyo. Area Ciencias Exactas,(CRICYT - CONICET), Adrian Ruiz Leal s/n. Parque General San Martin. (5500) Mendoza (Argentina)

    2010-07-15

    Energy use in the built environment is globally recognized as a key issue for sustainable urban development. In temperate-cold arid regions with a generous solar resource, such as those of western Argentina, adequate design and technology can substantially reduce the energy demand for space and water heating in urban buildings. The solar potential of low-density residential urban areas in the city of Mendoza's Metropolitan Area (MMA), has been studied earlier in this research. Several indicators of the solar potential were elaborated. They provide necessary information when planning and designing new urban structures or refurbishing existing ones. However, a more direct indicator, relating the available solar radiation during a heating season to the space volume to be heated, the Volumetric Insolation Factor (VIF), seems to be of most practical use as far as contributing a helpful evaluation indicator, to the above mentioned design processes. The present study follows the methodological steps used in the former research, evaluating comparatively the results of a Graphic-Computational Model and a Multiple Linear Regression Statistical Model. As in the earlier study, the good fit of both models' results clearly point at the reliability of the statistical procedure and its valuable contribution of a simplified calculation tool as its by-product. (author)

  13. Assessing the solar potential of low-density urban environments in Andean cities with desert climates: The case of the city of Mendoza, in Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Arboit, M.; Fernandez Llano, J.C.; Rosa, C. de [Instituto de Ciencias Humanas, Sociales y Ambientales (INCIHUSA - CONICET), R and D Unit, Laboratorio de Ambiente Humano y Vivienda (LAHV), Adrian Ruiz Leal s/n, Parque General San Martin 5500, Mendoza (Argentina); Diblasi, A. [Facultad de Ciencias Economicas, UNCuyo, Centro Universitario (5500) Mendoza (Argentina)

    2008-08-15

    Energy use in the built environment is globally recognized as a key issue for sustainable urban development. In tempered-cold arid regions with a generous solar resource, adequate design and technology can substantially reduce the energy demand for space and water heating in urban buildings. This study assessed the solar potential of low-density urban environments in the city of Mendoza, Argentina. The results of the study will be used to develop technical guidelines for urban and energy planning agencies and professionals involved in the production of habitat. The study included the following successive steps: (i) selection of a representative sample of analysis units (city blocks); (ii) selection of a series of urban and building variables; (iii) definition of indicators accounting for solar masking, building's potential use of the solar radiation on the whole urban area, and availability of adequate collecting areas to satisfy high percentages of the energy demand in low-density urban environments; and (iv) insolation of potential collectors simulated by a graphic-computational model developed in the R and D unit. Only the results for solar space heating are presented in this paper. The results, direct and statistical, indicate that it is technically feasible to meet the target solar fractions. At the same time, by means of the solar recycling of existing building stocks, it is possible to considerably reduce the environmental impacts due to the extraction of materials from, and the disposal of solid wastes into, the ecosystem. (author)

  14. Educación agrícola, enólogos y tecnologías para una vitivinicultura "de calidad", Mendoza, 1890-1930

    Directory of Open Access Journals (Sweden)

    Florencia Rodriguez Vázquez

    2014-08-01

    Full Text Available Sobre la base de la relación existente entre enseñanza y economía, el objetivo de este artículo es analizar la repercusión de las políticas públicas de enseñanza agrícola en la economía regional vitivinícola. Para ello, en primer lugar, nos centramos en los principales proyectos educativos sectoriales que hubo en Mendoza en el período de consolidación del modelo productivo, de base capitalista, y la contribución en este período de los técnicos vinculados a estos establecimientos.La reconstrucción operada se basa en datos obtenidos de fuentes primarias, éditas e inéditas, oficiales y no oficiales. Como se resultado, se demuestra que el Estado, nacional y provincial, respondió a las demandas de formación de recursos humanos, y la constitución de un subgrupo que inició discusiones técnicas y realizó importantes aportes sobre enología y vinificación.

  15. Larger Planet Radii Inferred from Stellar "Flicker" Brightness Variations of Bright Planet Host Stars

    CERN Document Server

    Bastien, Fabienne A; Pepper, Joshua

    2014-01-01

    Most extrasolar planets have been detected by their influence on their parent star, typically either gravitationally (the Doppler method) or by the small dip in brightness as the planet blocks a portion of the star (the transit method). Therefore, the accuracy with which we know the masses and radii of extrasolar planets depends directly on how well we know those of the stars, the latter usually determined from the measured stellar surface gravity, logg. Recent work has demonstrated that the short-timescale brightness variations ("flicker") of stars can be used to measure logg to a high accuracy of ~0.1-0.2 dex (Bastien et al. 2013). Here, we use flicker measurements of 289 bright (Kepmag<13) candidate planet-hosting stars with Teff=4500-6650 K to re-assess the stellar parameters and determine the resulting impact on derived planet properties. This re-assessment reveals that for the brightest planet-host stars, an astrophysical bias exists that contaminates the stellar sample with evolved stars: nearly 50%...

  16. Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF activity.

    Directory of Open Access Journals (Sweden)

    Gözde Isik

    Full Text Available HIV-1 acquisition can be prevented by broadly neutralizing antibodies (BrNAbs that target the envelope glycoprotein complex (Env. An ideal vaccine should therefore be able to induce BrNAbs that can provide immunity over a prolonged period of time, but the low intrinsic immunogenicity of HIV-1 Env makes the elicitation of such BrNAbs challenging. Co-stimulatory molecules can increase the immunogenicity of Env and we have engineered a soluble chimeric Env trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF domain. This chimeric molecule induced enhanced B and helper T cell responses in mice compared to Env without GM-CSF. We studied whether we could optimize the activity of the embedded GM-CSF as well as the antigenic structure of the Env component of the chimeric molecule. We assessed the effect of truncating GM-CSF, removing glycosylation-sites in GM-CSF, and adjusting the linker length between GM-CSF and Env. One of our designed Env(GM-CSF chimeras improved GM-CSF-dependent cell proliferation by 6-fold, reaching the same activity as soluble recombinant GM-CSF. In addition, we incorporated GM-CSF into a cleavable Env trimer and found that insertion of GM-CSF did not compromise Env cleavage, while Env cleavage did not compromise GM-CSF activity. Importantly, these optimized Env(GM-CSF proteins were able to differentiate human monocytes into cells with a macrophage-like phenotype. Chimeric Env(GM-CSF should be useful for improving humoral immunity against HIV-1 and these studies should inform the design of other chimeric proteins.

  17. High Brightness Neutron Source for Radiography

    Energy Technology Data Exchange (ETDEWEB)

    Cremer, J. T.; Piestrup, Melvin, A.; Gary, Charles, K.; Harris, Jack, L. Williams, David, J.; Jones, Glenn, E.; Vainionpaa, J. , H.; Fuller, Michael, J.; Rothbart, George, H.; Kwan, J., W.; Ludewigt, B., A.; Gough, R.., A..; Reijonen, Jani; Leung, Ka-Ngo

    2008-12-08

    This research and development program was designed to improve nondestructive evaluation of large mechanical objects by providing both fast and thermal neutron sources for radiography. Neutron radiography permits inspection inside objects that x-rays cannot penetrate and permits imaging of corrosion and cracks in low-density materials. Discovering of fatigue cracks and corrosion in piping without the necessity of insulation removal is possible. Neutron radiography sources can provide for the nondestructive testing interests of commercial and military aircraft, public utilities and petrochemical organizations. Three neutron prototype neutron generators were designed and fabricated based on original research done at the Lawrence Berkeley National Laboratory (LBNL). The research and development of these generators was successfully continued by LBNL and Adelphi Technology Inc. under this STTR. The original design goals of high neutron yield and generator robustness have been achieved, using new technology developed under this grant. In one prototype generator, the fast neutron yield and brightness was roughly 10 times larger than previously marketed neutron generators using the same deuterium-deuterium reaction. In another generator, we integrate a moderator with a fast neutron source, resulting in a high brightness thermal neutron generator. The moderator acts as both conventional moderator and mechanical and electrical support structure for the generator and effectively mimics a nuclear reactor. In addition to the new prototype generators, an entirely new plasma ion source for neutron production was developed. First developed by LBNL, this source uses a spiral antenna to more efficiently couple the RF radiation into the plasma, reducing the required gas pressure so that the generator head can be completely sealed, permitting the possible use of tritium gas. This also permits the generator to use the deuterium-tritium reaction to produce 14-MeV neutrons with increases

  18. Ultra-bright alkylated graphene quantum dots

    Science.gov (United States)

    Feng, Lan; Tang, Xing-Yan; Zhong, Yun-Xin; Liu, Yue-Wen; Song, Xue-Huan; Deng, Shun-Liu; Xie, Su-Yuan; Yan, Jia-Wei; Zheng, Lan-Sun

    2014-10-01

    Highly efficient and stable photoluminescence (PL) are urgently desired for graphene quantum dots (GQDs) to facilitate their prospective applications as optical materials. Here, we report the facile and straightforward synthesis of alkylated graphene quantum dots (AGQDs) via the solvothermal reaction of propagatively alkylated graphene sheets (PAGenes). In contrast to most GQDs reported so far, the synthesized AGQDs process pH-independent and ultra-bright PL with a relative quantum yield of up to 65%. Structural and chemical composition characterization demonstrated that the synthesized AGQDs are nearly oxygen-defect-free with alkyl groups decorated on edges and basal plane, which may contribute to their greatly improved pH tolerance and high quantum efficiency. The photocatalytic performance of AGQDs-P25 nanocomposites was evaluated by the degradation of Rhodamine B under visible light. The photocatalytic rate is ca. 5.9 times higher than that of pure P25, indicating that AGQDs could harness the visible spectrum of sunlight for energy conversion or environmental therapy.Highly efficient and stable photoluminescence (PL) are urgently desired for graphene quantum dots (GQDs) to facilitate their prospective applications as optical materials. Here, we report the facile and straightforward synthesis of alkylated graphene quantum dots (AGQDs) via the solvothermal reaction of propagatively alkylated graphene sheets (PAGenes). In contrast to most GQDs reported so far, the synthesized AGQDs process pH-independent and ultra-bright PL with a relative quantum yield of up to 65%. Structural and chemical composition characterization demonstrated that the synthesized AGQDs are nearly oxygen-defect-free with alkyl groups decorated on edges and basal plane, which may contribute to their greatly improved pH tolerance and high quantum efficiency. The photocatalytic performance of AGQDs-P25 nanocomposites was evaluated by the degradation of Rhodamine B under visible light. The

  19. New Insights on Non-Enzymatic Oxidation of Ganglioside GM1 Using Mass Spectrometry

    Science.gov (United States)

    Couto, Daniela; Melo, Tânia; Maciel, Elisabete; Campos, Ana; Alves, Eliana; Guedes, Sofia; Domingues, M. Rosário M.; Domingues, Pedro

    2016-08-01

    Gangliosides are acidic glycosphingolipids that are present in cell membranes and lipid raft domains, being particularly abundant in central nervous systems. They participate in modulating cell membrane properties, cell-cell recognition, cell regulation, and signaling. Disturbance in ganglioside metabolism has been correlated with the development of diseases, such as neurodegenerative diseases, and in inflammation. Both conditions are associated with an increased production of reactive oxidation species (ROS) that can induce changes in the structure of biomolecules, including lipids, leading to the loss or modification of their function. Oxidized phospholipids are usually involved in chronic diseases and inflammation. However, knowledge regarding oxidation of gangliosides is scarce. In order to evaluate the effect of ROS in gangliosides, an in vitro biomimetic model system was used to study the susceptibility of GM1 (Neu5Acα2-3(Galβ1-3GalNAcβ1-4)Galβ1-4Glcβ1Cer) to undergo oxidative modifications. Oxidation of GM1 under Fenton reaction conditions was monitored using high resolution electrospray ionization-mass spectrometry (ESI-MS) and tandem mass spectrometry (ESI-MS/MS). Upon oxidation, GM1 underwent oxidative cleavages in the carbohydrate chain, leading to the formation of other gangliosides GM2 (GalNAcβ1-4Gal(Neu5Acα2-3)1-4Glcβ1Cer), GM3 (Neu5Acα2-3Galβ1-4Glcβ1Cer), asialo-GM1 (Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1Cer), asialo-GM2 (GalNAcβ1-4Galβ1-4Glcβ1Cer), of the small glycolipids lactosylceramide (LacCer), glucosylceramide (GlcCer), and of ceramide (Cer). In addition, oxygenated GM1 and GM2 (as keto and hydroxy derivatives), glycans, oxidized glycans, and oxidized ceramides were also identified. Nonenzymatic oxidation of GM1 under oxidative stress contributes to the generation of other gangliosides that may participate in the imbalance of gangliosides metabolism in vivo, through uncontrolled enzymatic pathways and, consequently, play some role in

  20. Dark and bright vortex solitons in electromagnetically induced transparent media

    International Nuclear Information System (INIS)

    We show that dark and bright vortex solitons can exist in three-state electromagnetically induced transparent media under some appropriate conditions. We also analyse the stability of the dark and bright vortex solitons. This work may provide other research opportunities in nonlinear optical experiments and may result in a substantial impact on technology

  1. Low dimensional neutron moderators for enhanced source brightness

    DEFF Research Database (Denmark)

    Mezei, Ferenc; Zanini, Luca; Takibayev, Alan;

    2014-01-01

    for cold neutrons. This model leads to the conclusions that the optimal shape for high brightness para-hydrogen neutron moderators is the quasi 1-dimensional tube and these low dimensional moderators can also deliver much enhanced cold neutron brightness in fission reactor neutron sources, compared...

  2. Surface photometry of bulge dominated low surface brightness galaxies

    NARCIS (Netherlands)

    Beijersbergen, M; de Blok, WJG; van der Hulst, JM

    1999-01-01

    We present results of broad band BVRI observations of a sample of galaxies with a low surface brightness (LSB) disk and a bulge. These galaxies are well described as exponential disks and exponential bulges with no preferred value for either scale length or central surface brightness. The median B b

  3. Analysis of Bright Harvest Remote Analysis for Residential Solar Installations

    Energy Technology Data Exchange (ETDEWEB)

    Nangle, John [National Renewable Energy Lab. (NREL), Golden, CO (United States); Simon, Joseph [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-06-17

    Bright Harvest provides remote shading analysis and design products for residential PV system installers. The National Renewable Energy Laboratory (NREL) through the NREL Commercialization Assistance Program, completed comparative assessments between on-site measurements and remotely calculated values to validate the accuracy of Bright Harvest’s remote shading and power generation.

  4. Modular Zero Energy. BrightBuilt Home

    Energy Technology Data Exchange (ETDEWEB)

    Aldrich, Robb [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States). Steven Winters Associates, Inc.; Butterfield, Karla [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States). Steven Winters Associates, Inc.

    2016-03-01

    Kaplan Thompson Architects (KTA) has specialized in sustainable, energy-efficient buildings, and they have designed several custom, zero-energy homes in New England. These zero-energy projects have generally been high-end, custom homes with budgets that could accommodate advanced energy systems. In an attempt to make zero energy homes more affordable and accessible to a larger demographic, KTA explored modular construction as way to provide high-quality homes at lower costs. In the mid-2013, KTA formalized this concept when they launched BrightBuilt Home (BBH). The BBH mission is to offer a line of architect-designed, high-performance homes that are priced to offer substantial savings off the lifetime cost of a typical home and can be delivered in less time. For the past two years, CARB has worked with BBH and Keiser Homes (the primary modular manufacturer for BBH) to discuss challenges related to wall systems, HVAC, and quality control. In Spring of 2014, CARB and BBH began looking in detail on a home to be built in Lincolnville, ME by Black Bros. Builders. This report details the solution package specified for this modular plan and the challenges that arose during the project.

  5. Lyman Alpha Mapping Project (LAMP) Brightness Maps

    Science.gov (United States)

    Retherford, Kurt D.; Gladstone, G.; Stern, S.; Egan, A. F.; Miles, P. F.; Parker, J. W.; Greathouse, T. K.; Davis, M. W.; Slater, D. C.; Kaufmann, D. E.; Versteeg, M. H.; Feldman, P. D.; Hurley, D. M.; Pryor, W. R.; Hendrix, A. R.

    2010-10-01

    The Lyman Alpha Mapping Project (LAMP) is an ultraviolet (UV) spectrograph on the Lunar Reconnaissance Orbiter (LRO) that is designed to map the lunar albedo at far-UV wavelengths. LAMP primarily measures interplanetary Hydrogen Lyman-alpha sky-glow and far-UV starlight reflected from the night-side lunar surface, including permanently shadowed regions (PSRs) near the poles. Dayside observations are also obtained. Brightness maps sorted by wavelength (including the Lyman-alpha wavelength of 121.6 nm) are reported for the polar regions, with a few regions of interest reported in more detail. LAMP's spectral range of 58 nm to 196 nm includes a water ice spectral feature near 160 nm, which provides a diagnostic tool for detecting water on the lunar surface that is complementary to recent discoveries using infrared and radio frequency techniques. Progress towards producing far-UV albedo maps and searching for water ice signatures will be reported. We'll discuss how LAMP data may address questions regarding how water is formed on the moon, transported through the lunar atmosphere, and deposited in the PSRs.

  6. Dark Skies, Bright Kids Year 6

    Science.gov (United States)

    Liss, Sandra; Troup, Nicholas William; Johnson, Kelsey E.; Barcos-Munoz, Loreto D.; Beaton, Rachael; Bittle, Lauren; Borish, Henry J.; Burkhardt, Andrew; Corby, Joanna; Dean, Janice; Hancock, Danielle; King, Jennie; Prager, Brian; Romero, Charles; Sokal, Kimberly R.; Stierwalt, Sabrina; Wenger, Trey; Zucker, Catherine

    2015-01-01

    Now entering our sixth year of operation, Dark Skies, Bright Kids (DSBK) is an entirely volunteer-run outreach organization based out of the Department of Astronomy at the University of Virginia. Our core mission is to enhance elementary science education and literacy in central Virginia through fun, hands-on activities that introduce basic Astronomy concepts beyond Virginia's Standards of Learning. Our primary focus is hosting an 8-10 week after-school astronomy club at underserved elementary and middle schools. Each week, DSBK volunteers take the role of coaches to introduce astronomy-related concepts ranging from the Solar System to galaxies to astrobiology, and to lead students in interactive learning activities. Another hallmark of DSBK is hosting our Annual Central Virginia Star Party, a free event open to the community featuring star-gazing and planetarium shows.DSBK has amassed over 15,000 contact hours since 2009 and we continue to broaden our impact. One important step we have taken in the past year is to establish a graduate student led assessment program to identify and implement directed learning goals for DSBK outreach. The collection of student workbooks, observations, and volunteer surveys indicates broad scale success for the program both in terms of student learning and their perception of science. The data also reveal opportunities to improve our organizational and educational practices to maximize student achievement and overall volunteer satisfaction for DSBK's future clubs and outreach endeavors.

  7. Mechanical electrodeposition of bright nanocrystalline nickel

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A new mechanical electrodeposition technology was proposed, and nanocrystalline nickel deposit with bright and smooth surface was prepared in the bath without any additive agents. Unlike traditional methods, the novel technology employed dynamical hard particles to continuously polish the cathode surface and disturb the nearby solution during electrodepositing. Experimental results showed that the polishing effect of hard particles can effectively prevent the hydrogen bubbles and impurities from adhering on the deposit surface and avoid the production of pits, pinholes and nodules. Furthermore, comparing with the deposit prepared by traditional methods, the one prepared by the novel technology was substantially refined with grain size ranging from 30 to 80 nm. Every diffraction peak’s intensity of the deposit was reduced, the preferential orientation degree of (200) decreased and those of (111) and (220) increased. The microhardness notably increased. The magnetic properties were also changed with decreased saturation magnetization and increased coercive force. It was also found that variation of current density and cathode rotational speed could affect the structure and properties of the nickel deposits prepared by this technology.

  8. Antilensing: the bright side of voids.

    Science.gov (United States)

    Bolejko, Krzysztof; Clarkson, Chris; Maartens, Roy; Bacon, David; Meures, Nikolai; Beynon, Emma

    2013-01-11

    More than half of the volume of our Universe is occupied by cosmic voids. The lensing magnification effect from those underdense regions is generally thought to give a small dimming contribution: objects on the far side of a void are supposed to be observed as slightly smaller than if the void were not there, which together with conservation of surface brightness implies net reduction in photons received. This is predicted by the usual weak lensing integral of the density contrast along the line of sight. We show that this standard effect is swamped at low redshifts by a relativistic Doppler term that is typically neglected. Contrary to the usual expectation, objects on the far side of a void are brighter than they would be otherwise. Thus the local dynamics of matter in and near the void is crucial and is only captured by the full relativistic lensing convergence. There are also significant nonlinear corrections to the relativistic linear theory, which we show actually underpredicts the effect. We use exact solutions to estimate that these can be more than 20% for deep voids. This remains an important source of systematic errors for weak lensing density reconstruction in galaxy surveys and for supernovae observations, and may be the cause of the reported extra scatter of field supernovae located on the edge of voids compared to those in clusters. PMID:23383886

  9. Chromatic variations suppress suprathreshold brightness variations.

    Science.gov (United States)

    Kingdom, Frederick A A; Bell, Jason; Gheorghiu, Elena; Malkoc, Gokhan

    2010-01-01

    Most objects in natural scenes are suprathreshold in both color (chromatic) and luminance contrast. How salient is each dimension? We have developed a novel method employing a stimulus similar to that used by B. C. Regan and J. D. Mollon (1997) who studied the relative saliencies of the two chromatic cardinal directions. Our stimuli consist of left- and right-oblique modulations of color and/or luminance defined within a lattice of circles. In the "separated" condition, the two modulations were presented separately as forced-choice pairs, and the task was to indicate which was more salient. In the "combined" condition, the two orthogonal-in-orientation modulations were added, and the task was to indicate the more salient orientation. The ratio of color to luminance contrast at the PSE was calculated for both conditions. Across color directions, 48% more luminance contrast relative to color contrast was required to achieve a PSE in the "combined" compared to the "separated" condition. A second experiment showed that the PSE difference was due to the luminance being masked by the color, rather than due to superior color grouping. We conclude that suprathreshold brightness variations are masked by suprathreshold color variations. PMID:20884478

  10. Intercomparisons of Nine Sky Brightness Detectors

    Directory of Open Access Journals (Sweden)

    Henk Spoelstra

    2011-10-01

    Full Text Available Nine Sky Quality Meters (SQMs have been intercompared during a night time measurement campaign held in the Netherlands in April 2011. Since then the nine SQMs have been distributed across the Netherlands and form the Dutch network for monitoring night sky brightness. The goal of the intercomparison was to infer mutual calibration factors and obtain insight into the variability of the SQMs under different meteorological situations. An ensemble average is built from the individual measurements and used as a reference to infer the mutual calibration factors. Data required additional synchronization prior to the calibration determination, because the effect of moving clouds combined with small misalignments emerges as time jitter in the measurements. Initial scatter of the individual instruments lies between ±14%. Individual night time sums range from −16% to +20%. Intercalibration reduces this to 0.5%, and −7% to +9%, respectively. During the campaign the smallest luminance measured was 0.657 ± 0.003 mcd/m2 on 12 April, and the largest value was 5.94 ± 0.03 mcd/m2 on 2 April. During both occurrences interfering circumstances like snow cover or moonlight were absent.

  11. The Los Alamos high-brightness photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    O' Shea, P.G.

    1991-01-01

    For a number of years Los Alamos National Laboratory has been developing photocathode RF guns for high-brightness electron beam applications such as free-electron lasers (FELs). Previously thermionic high-voltage guns have been the source of choice for the electron accelerators used to drive FELs. The performance of such FELs is severely limited by the emittance growth produced by the subharmonic bunching process and also by the low peak current of the source. In a photoinjector, a laser driven photocathode is placed directly in a high-gradient RF accelerating cavity. A photocathode allows unsurpassed control over the current, and the spatial and temporal profile of the beam. In addition the electrodeless emission'' avoids many of the difficulties associated with multi-electrode guns, i.e. the electrons are accelerated very rapidly to relativistic energies, and there are no electrodes to distort the accelerating fields. For the past two years we have been integrating a photocathode into our existing FEL facility by replacing our thermionic gun and subharmonic bunchers with a high-gradient 1.3 GHz photoinjector. The photoinjector, which is approximately 0.6 m in length, produces 6 MeV, 300 A, 15 ps linac, and accelerated to a final energy of 40 MeV. We have recently begun lasing at wavelengths near 3 {mu}m. 16 refs., 2 figs., 5 tabs.

  12. Interpreting Central Surface Brightness and Color Profiles in Elliptical Galaxies

    Science.gov (United States)

    Silva, David R.; Wise, Michael W.

    1996-01-01

    Hubble Space Telescope imagery has revealed dust features in the central regions of many (50%--80%) nearby bright elliptical galaxies. If these features are an indication of an underlying smooth diffuse dust distribution, then the interpretation of central surface brightness and color profiles in elliptical galaxies becomes significantly more difficult. In this Letter, diagnostics for constraining the presence of such an underlying central dust distribution are presented. We show that easily detectable central color gradients and flattened central surface brightness profiles can be induced by even small amounts of smoothly distributed dust (~100 M⊙). Conversely, combinations of flat surface brightness profiles and flat color gradients or steep surface brightness profiles and steep color gradients are unlikely to be caused by dust. Taken as a whole, these results provide a simple observational tautology for constraining the existence of smooth diffuse dust distributions in the central regions of elliptical galaxies.

  13. Explaining the present GM business strategy on the EU food market: the gatekeepers' perspective.

    Science.gov (United States)

    Inghelbrecht, Linde; Dessein, Joost; Van Huylenbroeck, Guido

    2015-01-25

    The use of genetically modified (GM) crops and their applications is partially suppressed in European Union (EU) agriculture, even if one would expect otherwise given their complementarity with the neoliberal and industrialised EU agricultural regime in place. By applying a qualitative content analysis, this paper analyses how food manufacturers and retailers (referred to as gatekeepers in the food industry) explain and defend the exclusion of GM-labelled food products on the EU market. The study design places emphasis on the role of perceptions in the strategic behaviour of gatekeepers and on the role of interaction in this regard, as we assume that the way in which gatekeepers perceive the 'rules of the game' for commercialising GM crop applications on the EU food market will be influenced by their interaction with other agribusiness actors. In a first stage, the analysis determines thematic congruence in the (types of) perceptions that explain an agribusiness actor's overall interpretation of the EU business environment for GM crop applications. This perceived 'structuring arena' (SA) for GM crop applications - as conceptualised within our framework - contains areas of either internal and external tensions, that have a compelling or non-committal influence on the agribusiness actor's interpretation. In a second stage, the analysis particularly defines how gatekeepers in the food industry perceive and experience the SA for GM crop applications on the EU market, and how these perceptual tensions subsequently influence their strategic behaviour for GM-labelled products on the EU market. Finally, we highlight how these perceptions and actions (or inaction) suppress the main changes in practice that are necessary to manage this wicked problem.

  14. Responses to GM food content in context with food integrity issues: results from Australian population surveys.

    Science.gov (United States)

    Mohr, Philip; Golley, Sinéad

    2016-01-25

    This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives. PMID:26348278

  15. Differential expression of HLA-DR antigens in subsets of human CFU-GM.

    Science.gov (United States)

    Griffin, J D; Sabbath, K D; Herrmann, F; Larcom, P; Nichols, K; Kornacki, M; Levine, H; Cannistra, S A

    1985-10-01

    Expression of HLA-DR surface antigens by granulocyte/monocyte colony-forming cells (CFU-GM) may be important in the regulation of proliferation of these cells. Using immunological techniques to enrich for progenitor cells, we investigated the expression of HLA-DR in subsets of CFU-GM. "Early" (day 14) CFU-GM express higher levels of HLA-DR than do "late" (day 7) CFU-GM. Among late CFU-GM, cells destined to form monocyte (alpha-naphthyl acetate esterase-positive) colonies express higher levels of HLA-DR than do CFU-GM destined to form granulocyte (chloroacetate esterase-positive) colonies. Because high-level expression of DR antigen was a marker for monocyte differentiation, we examined several lymphokines for their effects on both DR expression and in vitro commitment to monocyte differentiation by myeloid precursor cells. DR antigen density could be increased by more than twofold over 48 hours upon exposure to gamma-interferon (gamma-IFN), whereas colony-stimulating factors had no effect. This was associated with a dose-dependent inhibition of total CFU-GM number, and a relative, but not absolute, increase in the ratio of monocyte colonies to granulocyte colonies. Similarly, in day 7 suspension cultures of purified myeloid precursor cells, gamma-IFN inhibited cell proliferation and increased the ratio of monocytes to granulocytes. Thus, despite the induction of high levels of HLA-DR antigen on precursor cells (a marker of monocyte commitment), the dominant in vitro effect of gamma-IFN was inhibition of granulocyte differentiation.

  16. GmFT2a, a soybean homolog of FLOWERING LOCUS T, is involved in flowering transition and maintenance.

    Directory of Open Access Journals (Sweden)

    Hongbo Sun

    Full Text Available BACKGROUND: Flowering reversion can be induced in soybean (Glycine max L. Merr., a typical short-day (SD dicot, by switching from SD to long-day (LD photoperiods. This process may involve florigen, putatively encoded by FLOWERING LOCUS T (FT in Arabidopsis thaliana. However, little is known about the potential function of soybean FT homologs in flowering reversion. METHODS: A photoperiod-responsive FT homologue GmFT (renamed as GmFT2a hereafter was cloned from the photoperiod-sensitive cultivar Zigongdongdou. GmFT2a gene expression under different photoperiods was analyzed by real-time quantitative PCR. In situ hybridization showed direct evidence for its expression during flowering-related processes. GmFT2a was shown to promote flowering using transgenic studies in Arabidopsis and soybean. The effects of photoperiod and temperature on GmFT2a expression were also analyzed in two cultivars with different photoperiod-sensitivities. RESULTS: GmFT2a expression is regulated by photoperiod. Analyses of GmFT2a transcripts revealed a strong correlation between GmFT2a expression and flowering maintenance. GmFT2a transcripts were observed continuously within the vascular tissue up to the shoot apex during flowering. By contrast, transcripts decreased to undetectable levels during flowering reversion. In grafting experiments, the early-flowering, photoperiod-insensitive stock Heihe27 promotes the appearance of GmFT2a transcripts in the shoot apex of scion Zigongdongdou under noninductive LD conditions. The photothermal effects of GmFT2a expression diversity in cultivars with different photoperiod-sensitivities and a hypothesis is proposed. CONCLUSION: GmFT2a expression is associated with flowering induction and maintenance. Therefore, GmFT2a is a potential target gene for soybean breeding, with the aim of increasing geographic adaptation of this crop.

  17. De la raíz a las puntas (con un insecto en medio) : la poesía erótica de Diego Hurtado de Mendoza «reloaded»

    OpenAIRE

    Díez, J. Ignacio

    2015-01-01

    La exclusión de las obras burlescas en la editio princeps de la poesía de Diego Hurtado de Mendoza obedece a un calculado gesto para rescatar la imagen «grave» de un antepasado ilustre del conde de Tendilla. Los preliminares de esta edición apuntan en la misma dirección. El editor del volumen, frey Juan Díaz Hidalgo, solo cita tres de esas obras («la azanahoria, cana, pulga y otras cosas burlescas»), lo que obliga a fijar un corpus conservado en los manuscritos. Los tres poemas son inequívoca...

  18. Estudios arqueológicos y bioarqueológicos en la cuenca media del Río Malargüe (provincia de Mendoza): el sitio bajada de las tropas 1

    OpenAIRE

    Luna, Leandro; Aranda, Claudia M.; Gil, Adolfo; Salgán, Laura; Tucker, Hugo

    2012-01-01

    En este artículo se describen y discuten los resultados de los trabajos de campo y de laboratorio realizados en el sitio Bajada de las Tropas 1 (BT1), localizado en la cuenca media del río Malargüe (Mendoza). Se identificaron restos correspondientes a cinco individuos con cronologías posteriores a los últimos 600 años 14C. Se presenta la caracterización bioarqueológica considerando aspectos como indicadores de estilo de vida, paleopatologías y dieta (valores de isótopos estables para colágeno...

  19. El proceso de contaminación hídrica en un oasis andino. La vida y la muerte por las acequias de Mendoza, Argentina, 1880-1980

    OpenAIRE

    Prieto, María del Rosario; Teresita Castrillejo; Patricia Dussel

    2006-01-01

    El objetivo de este artículo es estudiar, mediante evidencias documentales, el proceso de contaminación hídrica en el oasis norte de la provincia de Mendoza, desde el comienzo del desarrollo industrial (1880) hasta la actualidad, para explicar las causas del deterioro ambiental en el presente y proponer manejos hídricos alternativos. Se ha analizado también la evolución de las representaciones sociales acerca de la contaminación hídrica.

  20. La “empresarialización” de la gestión pública y la participación ciudadana : El Facebook de la ciudad de Mendoza

    OpenAIRE

    Mas, Fernando

    2014-01-01

    En el presente artículo abordaremos la “empresarialización” de la gestión pública y de su lenguaje. Este proceso se ha visto acentuado desde las últimas tres décadas con la reafirmación del neoliberalismo y su racionalidad gubernamental. Decidimos tomar como fenómeno de estudio a la fan page de Facebook del Municipio de Mendoza. Consideramos pertinente esta plataforma porque resultaría un buen ejemplo de cómo los organismos gubernamentales emulan en su administración y comunicación a las empr...