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Sample records for breast-specific gamma camera

  1. Occult Breast Cancer: Scintimammography with High-Resolution Breast-specific Gamma Camera in Women at High Risk for Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Rachel F. Brem; Jocelyn A. Rapelyea; , Gilat Zisman; Kevin Mohtashemi; Joyce Raub; Christine B. Teal; Stan Majewski; Benjamin L. Welch

    2005-08-01

    To prospectively evaluate a high-resolution breast-specific gamma camera for depicting occult breast cancer in women at high risk for breast cancer but with normal mammographic and physical examination findings. MATERIALS AND METHODS: Institutional Review Board approval and informed consent were obtained. The study was HIPAA compliant. Ninety-four high-risk women (age range, 36-78 years; mean, 55 years) with normal mammographic (Breast Imaging Reporting and Data System [BI-RADS] 1 or 2) and physical examination findings were evaluated with scintimammography. After injection with 25-30 mCi (925-1110 MBq) of technetium 99m sestamibi, patients were imaged with a high-resolution small-field-of-view breast-specific gamma camera in craniocaudal and mediolateral oblique projections. Scintimammograms were prospectively classified according to focal radiotracer uptake as normal (score of 1), with no focal or diffuse uptake; benign (score of 2), with minimal patchy uptake; probably benign (score of 3), with scattered patchy uptake; probably abnormal (score of 4), with mild focal radiotracer uptake; and abnormal (score of 5), with marked focal radiotracer uptake. Mammographic breast density was categorized according to BI-RADS criteria. Patients with normal scintimammograms (scores of 1, 2, or 3) were followed up for 1 year with an annual mammogram, physical examination, and repeat scintimammography. Patients with abnormal scintimammograms (scores of 4 or 5) underwent ultrasonography (US), and those with focal hypoechoic lesions underwent biopsy. If no lesion was found during US, patients were followed up with scintimammography. Specific pathologic findings were compared with scintimammographic findings. RESULTS: Of 94 women, 78 (83%) had normal scintimammograms (score of 1, 2, or 3) at initial examination and 16 (17%) had abnormal scintimammograms (score of 4 or 5). Fourteen (88%) of the 16 patients had either benign findings at biopsy or no focal abnormality at US; in two

  2. Gamma camera

    International Nuclear Information System (INIS)

    The design of a collimation system for a gamma camera for use in nuclear medicine is described. When used with a 2-dimensional position sensitive radiation detector, the novel system can produce superior images than conventional cameras. The optimal thickness and positions of the collimators are derived mathematically. (U.K.)

  3. Gamma ray camera

    International Nuclear Information System (INIS)

    An improved Anger-type gamma ray camera utilizes a proximity-type image intensifier tube. It has a greater capability for distinguishing between incident and scattered radiation, and greater spatial resolution capabilities

  4. Gamma camera system

    International Nuclear Information System (INIS)

    A detailed description is given of a novel gamma camera which is designed to produce superior images than conventional cameras used in nuclear medicine. The detector consists of a solid state detector (e.g. germanium) which is formed to have a plurality of discrete components to enable 2-dimensional position identification. Details of the electronic processing circuits are given and the problems and limitations introduced by noise are discussed in full. (U.K.)

  5. Gamma ray camera

    International Nuclear Information System (INIS)

    An Anger gamma ray camera is improved by the substitution of a gamma ray sensitive, proximity type image intensifier tube for the scintillator screen in the Anger camera. The image intensifier tube has a negatively charged flat scintillator screen, a flat photocathode layer, and a grounded, flat output phosphor display screen, all of which have the same dimension to maintain unit image magnification; all components are contained within a grounded metallic tube, with a metallic, inwardly curved input window between the scintillator screen and a collimator. The display screen can be viewed by an array of photomultipliers or solid state detectors. There are two photocathodes and two phosphor screens to give a two stage intensification, the two stages being optically coupled by a light guide. (author)

  6. The DRAGO gamma camera

    International Nuclear Information System (INIS)

    In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm2, coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated 57Co source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45 deg. with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.

  7. The DRAGO gamma camera

    Science.gov (United States)

    Fiorini, C.; Gola, A.; Peloso, R.; Longoni, A.; Lechner, P.; Soltau, H.; Strüder, L.; Ottobrini, L.; Martelli, C.; Lui, R.; Madaschi, L.; Belloli, S.

    2010-04-01

    In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm2, coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated C57o source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45° with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.

  8. Novel gamma cameras

    International Nuclear Information System (INIS)

    The gamma-ray cameras described are based on radiation imaging devices which permit the direct recording of the distribution of radioactive material from a radiative source, such as a human organ. They consist in principle of a collimator, a converter matrix converting gamma photons to electrons, and an electron image multiplier producing a multiplied electron output, and means for reading out the information. The electron image multiplier is a device which produces a multiplied electron image. It can be in principle, either gas avalanche electron multiplier or a multi-channel plate. The multi-channel plate employed is a novel device, described elsewhere. The three described embodiments, in which the converter matrix can be either of metal type or of scintillation crystal type, were designed and are being developed

  9. Gamma camera system

    International Nuclear Information System (INIS)

    The invention provides a composite solid state detector for use in deriving a display, by spatial coordinate information, of the distribution or radiation emanating from a source within a region of interest, comprising several solid state detector components, each having a given surface arranged for exposure to impinging radiation and exhibiting discrete interactions therewith at given spatially definable locations. The surface of each component and the surface disposed opposite and substantially parallel thereto are associated with impedence means configured to provide for each opposed surface outputs for signals relating the given location of the interactions with one spatial coordinate parameter of one select directional sense. The detector components are arranged to provide groupings of adjacently disposed surfaces mutually linearly oriented to exhibit a common directional sense of the spatial coordinate parameter. Means interconnect at least two of the outputs associated with each of the surfaces within a given grouping for collecting the signals deriving therefrom. The invention also provides a camera system for imaging the distribution of a source of gamma radiation situated within a region of interest

  10. The application of breast specific gamma imaging and positron emission mammography in the diagnosis and therapy of breast cancer

    International Nuclear Information System (INIS)

    Breast-specific gamma imaging (BSGI) and positron emission mammography (PEM) have the high resolution in diagnosing breast lesions with minimum diameter of 3 mm. Both BSGI and PEM are functional imaging modalities, which have no relation with breast tissue density, implanted prosthesis, scar formation and so on. This review elaborates the application of BSGI and PEM in the early diagnosis, treatment protocols and evaluation of efficacy for the patients with breast cancer. (authors)

  11. Gamma camera with reflectivity mask

    International Nuclear Information System (INIS)

    A gamma camera is described with a plurality of photodetectors arranged for locating flashes of light produced by a scintillator in response to incident radiation. Masking material is arranged in a radially symmetric pattern on the front face of the scintillator about the axis of each photodetector to reduce the amount of internal reflection of optical photons induced by gamma ray photons

  12. Decision about buying a gamma camera

    International Nuclear Information System (INIS)

    A large part of the referral to a nuclear medicine department is usually for imaging studies. Sooner or later, the nuclear medicine specialist will be called upon to make a decision about when and what type of gamma camera to buy. There is no longer an option of choosing between a rectilinear scanner and a gamma camera as the former is virtually out of the market. The decision that one has to make is when to invest in a gamma camera, and then on what basis to select the gamma camera

  13. Gamma camera with reflectivity mask

    International Nuclear Information System (INIS)

    In accordance with the present invention there is provided a radiographic camera comprising: a scintillator; a plurality of photodectors positioned to face said scintillator; a plurality of masked regions formed upon a face of said scintillator opposite said photdetectors and positioned coaxially with respective ones of said photodetectors for decreasing the amount of internal reflection of optical photons generated within said scintillator. (auth)

  14. Progress in gamma-camera quality control

    International Nuclear Information System (INIS)

    The latest developments in the art of quality control of gamma cameras are emphasized in a simple historical manner. The exhibit describes methods developed by the Bureau of Radiological Health (BRH) in comparison with previously accepted techniques for routine evaluation of gamma-camera performance. Gamma cameras require periodic testing of their performance parameters to ensure that their optimum imaging capability is maintained. Quality control parameters reviewed are field uniformity, spatial distortion, intrinsic and spatial resolution, and temporal resolution. The methods developed for the measurement of these parameters are simple, not requiring additional electronic equipment or computers. The data has been arranged in six panels as follows: schematic diagrams of the most important test patterns used in nuclear medicine; field uniformity; regional displacements in transmission pattern image; spatial resolution using the BRH line-source phantom; instrinsic resolution using the BRH Test Pattern; and Temporal resolution and count losses at high counting rates

  15. An imaging system for a gamma camera

    International Nuclear Information System (INIS)

    A detailed description is given of a novel gamma camera which is designed to produce superior images than conventional cameras used in nuclear medicine. The detector consists of a solid state detector (e.g. germanium) which is formed to have a plurality of discrete components to enable 2-dimensional position identification. Details of the electronic processing circuits are given and the problems and limitations introduced by noise are discussed in full. (U.K.)

  16. Advanced system for Gamma Cameras modernization

    International Nuclear Information System (INIS)

    Analog and digital gamma cameras still largely used in developing countries. Many of them rely in old hardware electronics, which in many cases limits their use in actual nuclear medicine diagnostic studies. Consequently, there are different worldwide companies that produce medical equipment engaged into a partial or total Gamma Cameras modernization. Present work has demonstrated the possibility of substitution of almost entire signal processing electronics placed at inside a Gamma Camera detector head by a digitizer PCI card. this card includes four 12 Bits Analog-to-Digital-Converters of 50 MHz speed. It has been installed in a PC and controlled through software developed in Lab View. Besides, there were done some changes to the hardware inside the detector head including redesign of the Orientation Display Block (ODA card). Also a new electronic design was added to the Microprocessor Control Block (MPA card) which comprised a PIC micro controller acting as a tuning system for individual Photomultiplier Tubes. The images, obtained by measurement of 99mTc point radioactive source, using modernized camera head demonstrate its overall performance. The system was developed and tested in an old Gamma Camera ORBITER II SIEMENS GAMMASONIC at National Institute of Oncology and Radiobiology (INOR) under CAMELUD project supported by National Program PNOULU and IAEA . (Author)

  17. Gamma cameras - a method of evaluation

    International Nuclear Information System (INIS)

    Full text: With the sophistication and longevity of the modern gamma camera it is not often that the need arises to evaluate a gamma camera for purchase. We have recently been placed in the position of retiring our two single headed cameras of some vintage and replacing them with a state of the art dual head variable angle gamma camera. The process used for the evaluation consisted of five parts: (1) Evaluation of the technical specification as expressed in the tender document; (2) A questionnaire adapted from the British Society of Nuclear Medicine; (3) Site visits to assess gantry configuration, movement, patient access and occupational health, welfare and safety considerations; (4) Evaluation of the processing systems offered; (5) Whole of life costing based on equally configured systems. The results of each part of the evaluation were expressed using a weighted matrix analysis with each of the criteria assessed being weighted in accordance with their importance to the provision of an effective nuclear medicine service for our centre and the particular importance to paediatric nuclear medicine. This analysis provided an objective assessment of each gamma camera system from which a purchase recommendation was made. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  18. Performance assessment of gamma cameras. Part 1

    International Nuclear Information System (INIS)

    The Dept. of Health and Social Security and the Scottish Home and Health Dept. has sponsored a programme of measurements of the important performance characteristics of 15 leading types of gamma cameras providing a routine radionuclide imaging service in hospitals throughout the UK. Measurements have been made of intrinsic resolution, system resolution, non-uniformity, spatial distortion, count rate performance, sensitivity, energy resolution and shield leakage. The main aim of this performance assessment was to provide sound information to the NHS to ease the task of those responsible for the purchase of gamma cameras. (U.K.)

  19. GAMPIX: A new generation of gamma camera

    Science.gov (United States)

    Gmar, M.; Agelou, M.; Carrel, F.; Schoepff, V.

    2011-10-01

    Gamma imaging is a technique of great interest in several fields such as homeland security or decommissioning/dismantling of nuclear facilities in order to localize hot spots of radioactivity. In the nineties, previous works led by CEA LIST resulted in the development of a first generation of gamma camera called CARTOGAM, now commercialized by AREVA CANBERRA. Even if its performances can be adapted to many applications, its weight of 15 kg can be an issue. For several years, CEA LIST has been developing a new generation of gamma camera, called GAMPIX. This system is mainly based on the Medipix2 chip, hybridized to a 1 mm thick CdTe substrate. A coded mask replaces the pinhole collimator in order to increase the sensitivity of the gamma camera. Hence, we obtained a very compact device (global weight less than 1 kg without any shielding), which is easy to handle and to use. In this article, we present the main characteristics of GAMPIX and we expose the first experimental results illustrating the performances of this new generation of gamma camera.

  20. New nuclear medicine gamma camera systems

    International Nuclear Information System (INIS)

    The acquisition of the Open E.CAM and DIACAM gamma cameras by Makati Medical Center is expected to enhance the capabilities of its nuclear medicine facilities. When used as an aid to diagnosis, nuclear medicine entails the introduction of a minute amount of radioactive material into the patient; thus, no reaction or side-effect is expected. When it reaches the particular target organ, depending on the radiopharmaceutical, a lesion will appear as a decrease (cold) area or increase (hot) area in the radioactive distribution as recorded byu the gamma cameras. Gamma camera images in slices or SPECT (Single Photon Emission Computer Tomography), increase the sensitivity and accuracy in detecting smaller and deeply seated lesions, which otherwise may not be detected in the regular single planar images. Due to the 'open' design of the equipment, claustrophobic patients will no longer feel enclosed during the procedure. These new gamma cameras yield improved resolution and superb image quality, and the higher photon sensitivity shortens imaging acquisition time. The E.CAM, which is the latest generation gamma camera, is featured by its variable angle dual-head system, the only one available in the Philipines, and the excellent choice for Myocardial Perfusion Imaging (MPI). From the usual 45 minutes, the acquisition time for gated SPECT imaging of the heart has now been remarkably reduced to 12 minutes. 'Gated' infers snap-shots of the heart in selected phases of its contraction and relaxation as triggered by ECG. The DIACAM is installed in a room with access outside the main entrance of the department, intended specially for bed-borne patients. Both systems are equipped with a network of high performance Macintosh ICOND acquisition and processing computers. Added to the hardware is the ICON processing software which allows total simultaneous acquisition and processing capabilities in the same operator's terminal. Video film and color printers are also provided. Together

  1. Portable mini gamma camera for medical applications

    CERN Document Server

    Porras, E; Benlloch, J M; El-Djalil-Kadi-Hanifi, M; López, S; Pavon, N; Ruiz, J A; Sánchez, F; Sebastiá, A

    2002-01-01

    A small, portable and low-cost gamma camera for medical applications has been developed and clinically tested. This camera, based on a scintillator crystal and a Position Sensitive Photo-Multiplier Tube, has a useful field of view of 4.6 cm diameter and provides 2.2 mm of intrinsic spatial resolution. Its mobility and light weight allow to reach the patient from any desired direction. This camera images small organs with high efficiency and so addresses the demand for devices of specific clinical applications. In this paper, we present the camera and briefly describe the procedures that have led us to choose its configuration and the image reconstruction method. The clinical tests and diagnostic capability are also presented and discussed.

  2. Portable mini gamma camera for medical applications

    International Nuclear Information System (INIS)

    A small, portable and low-cost gamma camera for medical applications has been developed and clinically tested. This camera, based on a scintillator crystal and a Position Sensitive Photo-Multiplier Tube, has a useful field of view of 4.6 cm diameter and provides 2.2 mm of intrinsic spatial resolution. Its mobility and light weight allow to reach the patient from any desired direction. This camera images small organs with high efficiency and so addresses the demand for devices of specific clinical applications. In this paper, we present the camera and briefly describe the procedures that have led us to choose its configuration and the image reconstruction method. The clinical tests and diagnostic capability are also presented and discussed

  3. Toward standardising gamma camera quality control procedures

    Science.gov (United States)

    Alkhorayef, M. A.; Alnaaimi, M. A.; Alduaij, M. A.; Mohamed, M. O.; Ibahim, S. Y.; Alkandari, F. A.; Bradley, D. A.

    2015-11-01

    Attaining high standards of efficiency and reliability in the practice of nuclear medicine requires appropriate quality control (QC) programs. For instance, the regular evaluation and comparison of extrinsic and intrinsic flood-field uniformity enables the quick correction of many gamma camera problems. Whereas QC tests for uniformity are usually performed by exposing the gamma camera crystal to a uniform flux of gamma radiation from a source of known activity, such protocols can vary significantly. Thus, there is a need for optimization and standardization, in part to allow direct comparison between gamma cameras from different vendors. In the present study, intrinsic uniformity was examined as a function of source distance, source activity, source volume and number of counts. The extrinsic uniformity and spatial resolution were also examined. Proper standard QC procedures need to be implemented because of the continual development of nuclear medicine imaging technology and the rapid expansion and increasing complexity of hybrid imaging system data. The present work seeks to promote a set of standard testing procedures to contribute to the delivery of safe and effective nuclear medicine services.

  4. 21 CFR 892.1100 - Scintillation (gamma) camera.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Scintillation (gamma) camera. 892.1100 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1100 Scintillation (gamma) camera. (a) Identification. A scintillation (gamma) camera is a device intended to image the distribution of radionuclides...

  5. Modeling and simulation of gamma camera

    International Nuclear Information System (INIS)

    Simulation techniques play a vital role in designing of sophisticated instruments and also for the training of operating and maintenance staff. Gamma camera systems have been used for functional imaging in nuclear medicine. Functional images are derived from the external counting of the gamma emitting radioactive tracer that after introduction in to the body mimics the behavior of native biochemical compound. The position sensitive detector yield the coordinates of the gamma ray interaction with the detector and are used to estimate the point of gamma ray emission within the tracer distribution space. This advanced imaging device is thus dependent on the performance of algorithm for coordinate computing, estimation of point of emission, generation of image and display of the image data. Contemporary systems also have protocols for quality control and clinical evaluation of imaging studies. Simulation of this processing leads to understanding of the basic camera design problems. This report describes a PC based package for design and simulation of gamma camera along with the options of simulating data acquisition and quality control of imaging studies. Image display and data processing the other options implemented in SIMCAM will be described in separate reports (under preparation). Gamma camera modeling and simulation in SIMCAM has preset configuration of the design parameters for various sizes of crystal detector with the option to pack the PMT on hexagon or square lattice. Different algorithm for computation of coordinates and spatial distortion removal are allowed in addition to the simulation of energy correction circuit. The user can simulate different static, dynamic, MUGA and SPECT studies. The acquired/ simulated data is processed for quality control and clinical evaluation of the imaging studies. Results show that the program can be used to assess these performances. Also the variations in performance parameters can be assessed due to the induced

  6. Imaging of gamma emitters using scintillation cameras

    Science.gov (United States)

    Ricard, Marcel

    2004-07-01

    Since their introduction by Hal Anger in the late 1950s, the gamma cameras have been widely used in the field of nuclear medicine. The original concept is based on the association of a large field of view scintillator optically coupled with an array of photomultiplier tubes (PMTs), in order to locate the position of interactions inside the crystal. Using a dedicated accessory, like a parallel hole collimator, to focus the field of view toward a predefined direction, it is possible to built up an image of the radioactive distribution. In terms of imaging performances, three main characteristics are commonly considered: uniformity, spatial resolution and energy resolution. Major improvements were mainly due to progress in terms of industrial process regarding analogical electronic, crystal growing or PMTs manufacturing. Today's gamma camera is highly digital, from the PMTs to the display. All the corrections are applied "on the fly" using up to date signal processing techniques. At the same time some significant progresses have been achieved in the field of collimators. Finally, two new technologies have been implemented, solid detectors like CdTe or CdZnTe, and pixellized scintillators plus photodiodes or position sensitive photomultiplier tubes. These solutions are particularly well adapted to build dedicated gamma camera for breast or intraoperative imaging.

  7. Imaging of gamma emitters using scintillation cameras

    Energy Technology Data Exchange (ETDEWEB)

    Ricard, Marcel E-mail: ricard@igr.fr

    2004-07-11

    Since their introduction by Hal Anger in the late 1950s, the gamma cameras have been widely used in the field of nuclear medicine. The original concept is based on the association of a large field of view scintillator optically coupled with an array of photomultiplier tubes (PMTs), in order to locate the position of interactions inside the crystal. Using a dedicated accessory, like a parallel hole collimator, to focus the field of view toward a predefined direction, it is possible to built up an image of the radioactive distribution. In terms of imaging performances, three main characteristics are commonly considered: uniformity, spatial resolution and energy resolution. Major improvements were mainly due to progress in terms of industrial process regarding analogical electronic, crystal growing or PMTs manufacturing. Today's gamma camera is highly digital, from the PMTs to the display. All the corrections are applied 'on the fly' using up to date signal processing techniques. At the same time some significant progresses have been achieved in the field of collimators. Finally, two new technologies have been implemented, solid detectors like CdTe or CdZnTe, and pixellized scintillators plus photodiodes or position sensitive photomultiplier tubes. These solutions are particularly well adapted to build dedicated gamma camera for breast or intraoperative imaging.

  8. Imaging of gamma emitters using scintillation cameras

    International Nuclear Information System (INIS)

    Since their introduction by Hal Anger in the late 1950s, the gamma cameras have been widely used in the field of nuclear medicine. The original concept is based on the association of a large field of view scintillator optically coupled with an array of photomultiplier tubes (PMTs), in order to locate the position of interactions inside the crystal. Using a dedicated accessory, like a parallel hole collimator, to focus the field of view toward a predefined direction, it is possible to built up an image of the radioactive distribution. In terms of imaging performances, three main characteristics are commonly considered: uniformity, spatial resolution and energy resolution. Major improvements were mainly due to progress in terms of industrial process regarding analogical electronic, crystal growing or PMTs manufacturing. Today's gamma camera is highly digital, from the PMTs to the display. All the corrections are applied 'on the fly' using up to date signal processing techniques. At the same time some significant progresses have been achieved in the field of collimators. Finally, two new technologies have been implemented, solid detectors like CdTe or CdZnTe, and pixellized scintillators plus photodiodes or position sensitive photomultiplier tubes. These solutions are particularly well adapted to build dedicated gamma camera for breast or intraoperative imaging

  9. Imaging performances of the DRAGO gamma camera

    International Nuclear Information System (INIS)

    In this work, we present the results of the experimental characterization of the DRAGO gamma camera. This camera is based on a monolithic array of 77 Silicon Drift Detectors (SDDs), with a total active area of 6.7 cm2, coupled to a single CsI(Tl) scintillator crystal, 5 mm thick. The use of an array of SDDs provides high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits has been developed. Performances achieved in gamma-ray imaging using this camera are here reported. When imaging a 0.2 mm collimated 57Co source (122 keV) over different points of the active area, a spatial resolution ranging between 0.25 and 0.5 mm has been measured. The depth of interaction capability of the detector, thanks to a maximum likelihood reconstruction algorithm here adopted, has been also investigated by imaging a collimated beam tilted to an angle of 45 deg. with respect to the scintillator surface.

  10. Scintillating array gamma camera for clinical use

    International Nuclear Information System (INIS)

    Dedicated gamma cameras for specific clinical application are representing a new trend in nuclear medicine. They are based on position sensitive photo multiplier tubes (PSPMT). The main intrinsic limitation of large area PSPMT (5'' diameter) is the photocathode glass window. Coupling to a planar scintillation crystal strongly affects the useful active area and the intrinsic spatial resolution. To overcome this limitation at University of Rome ''La Sapienza'' was developed the first 5'' diameter gamma camera consisting of a Hamamatsu R3292 PSPMT coupled to 50 x 50 YAP:Ce scintillating array. The array pixel size is 2 x 2 mm2 and the overall dimension of multi-crystal is 10 x 10 x 1 cm3. Resistive chains were used to calculate the centroid. The scintillating array produces a focused light spot minimising the spread introduced by PSPMT glass window. The intrinsic spatial resolution varied between 2 and 2.7 mm. The position linearity and useful active area resulted in good agreement with intrinsic one obtained by light spot irradiation. The real limitation was the poor energy resolution of an individual crystal (40%) and the poor uniformity response of PSPMT (within ±15%). A correction matrix was then carried out by which a 57% of total energy resolution was obtained for the whole matrix. The camera is currently operating as single photon emission mammography (SPEM) and it is producing breast functional images for malignant tumour detection using the same geometry as standard X-ray mammography. (orig.)

  11. Gamma camera based FDG PET in oncology

    International Nuclear Information System (INIS)

    Positron Emission Tomography(PET) was introduced as a research tool in the 1970s and it took about 20 years before PET became an useful clinical imaging modality. In the USA, insurance coverage for PET procedures in the 1990s was the turning point, I believe, for this progress. Initially PET was used in neurology but recently more than 80% of PET procedures are in oncological applications. I firmly believe, in the 21st century, one can not manage cancer patients properly without PET and PET is very important medical imaging modality in basic and clinical sciences. PET is grouped into 2 categories; conventional (c) and gamma camera based (CB) PET. CBPET is more readily available utilizing dual-head gamma cameras and commercially available FDG to many medical centers at low cost to patients. In fact there are more CBPET in operation than cPET in the USA. CBPET is inferior to cPET in its performance but clinical studies in oncology is feasible without expensive infrastructures such as staffing, rooms and equipments. At Ajou university Hospital, CBPET was installed in late 1997 for the first time in Korea as well as in Asia and the system has been used successfully and effectively in oncological applications. Our was the fourth PET operation in Korea and I believe this may have been instrumental for other institutions got interested in clinical PET. The following is a brief description of our clinical experience of FDG CBPET in oncology

  12. Background {sup 99m}Tc-methoxyisobutylisonitrile uptake of breast-specific gamma imaging in relation to background parenchymal enhancement in magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hai-Jeon; Kim, Bom Sahn [Ewha Womans University, Department of Nuclear Medicine, Yangchun-Ku, Seoul (Korea, Republic of); Kim, Yemi [Ewha Womans University, Clinical Research Institute and Department of Conservative Dentistry, Seoul (Korea, Republic of); Lee, Jee Eun [Ewha Womans University, Department of Radiology, Seoul (Korea, Republic of)

    2015-01-15

    This study investigated factors that could affect background uptake of {sup 99m}Tc- methoxyisobutylisonitrile (MIBI) on normal breast by breast-specific gamma imaging (BSGI). In addition, the impact of background {sup 99m}Tc-MIBI uptake on the diagnostic performance of BSGI was further investigated. One hundred forty-five women with unilateral breast cancer who underwent BSGI, MRI, and mammography were retrospectively enrolled. Background uptake on BSGI was evaluated qualitatively and quantitatively. Patients were classified into non-dense and dense breast groups according to mammographic breast density. Background parenchymal enhancement (BPE) was rated according to BI-RADS classification. The relationship of age, menopausal status, mammographic breast density, and BPE with background {sup 99m}Tc-MIBI uptake was analyzed. Heterogeneous texture and high background uptake ratio on BSGI were significantly correlated with younger age (p < 0.001, respectively), premenopausal status (p < 0.001 and p = 0.003), dense breast (p < 0.001, respectively), and marked BPE (p < 0.001, respectively). On multivariate analysis, only BPE remained a significant factor for background MIBI uptake (p < 0.001).There was a significant reduction in positive predictive value (p = 0.024 and p = 0.002) as background MIBI uptake and BPE grade increased. BPE on MRI was the most important factor for background MIBI uptake on BSGI. High background MIBI uptake or marked BPE can diminish the diagnostic performance of BSGI. (orig.)

  13. Acceptance tests of a new gamma camera

    International Nuclear Information System (INIS)

    For best patient service, a QA programme is needed to produce quantitative/qualitative data and keep records of the results and equipment faults. Gamma cameras must be checked against the manufacturer's specifications.The service manual is usually useful to achieve this goal. Acceptance tests are very important not only to accept a new gamma camera system for routine clinical use but also to have a role in a reference for future measurements. In this study, acceptance tests were performed for a new gamma camera in our department. It is a General Electric MG system with two detectors, two collimators. They are low energy general purpose (LEGP) and medium energy general purpose (MEGP). All intrinsic calibrations and corrections were done by the service engineer at installation (PM tune, dynamic correction, energy calibration, geometric calibration, energy correction, linearity correction and second order corrections).After installation, calibrations and corrections, a close physical inspection of the mechanical and electrical safety aspects of the cameras were done by the responsible physicist of the department. The planar system is based on measurement of system uniformity, resolution/linearity and multiple window spatial registration. All test procedures were performed according to NEMA procedures developed by the manufacturer. Intrinsic uniformity: NEMA uniformity was done first by using service manual and then other isotope uniformities were acquired with 99mTc, 131I, 201Tl and 67Ga. They were evaluated qualitatively and quantitatively, but non-uniformities were observed, especially for detector II, The service engineers repeated all tests and made necessary corrections. We repeated all the intrinsic uniformity tests. 99mTc intrinsic images were also performed at 'no correction', 'no energy correction', 'no linearity correction', 'all correction' and '±10% off peak', and compared. Extrinsic uniformity: At the beginning, collimators were checked for defects

  14. Scinticor: A new digital gamma camera

    International Nuclear Information System (INIS)

    A new mobile gamma camera, Scinticor, has been developed with major improvements in design and performance. The instrument has a new scintillation detector which is a block of NaI (T1), (8x8x1'') optically divided into (20x20) elements with 115 photomuliplier tubes (PMT's) coupled to the scintillation exit glass of the crystal. Integrated hybrid circuits on each PMT transform the signal to a digital pulse which is the input to the digital positioning logic and dual window pulse height analyzer. Detector reliability is enhanced by automatic electronic tuning of each PMT. A new high sensitivity collimator provides 70% greater sensitivity than the present multi crystal collimator with same FWHM. The detector's special purpose array processor performs in real time (up to 100 frames/sec): ECG digitization, creation of first pass cardiac functional images and corrections for field uniformity, deadtime, radioactive decay, and environmental background. Data transmission to the mobile data processing console is via a 10Mb/s fiber optic link. Initial results indicate a major advance in collimated detector sensitivity and count rate with saturation over 1,000,000 cps. Energy resolution is 25% FWHM at 122 keV, Dynamic Edge Resolution is 3mm, Static Resoltion is 10mm. Initial clinical studies indicate this instrument is suitable for a wide range of dynamic studies

  15. Validity of breast-specific gamma imaging for Breast Imaging Reporting and Data System 4 lesions on mammography and/or ultrasound

    Science.gov (United States)

    Cho, Min Jeng; Yu, Yeong Beom; Park, Kyoung Sik; Chung, Hyun Woo; So, Young; Choi, Nami; Kim, Mi Young

    2016-01-01

    Purpose The purpose of this study was to assess the breast-specific gamma imaging (BSGI) in Breast Imaging Reporting and Data System (BI-RADS) 4 lesions on mammography and/or ultrasound. Methods We performed a retrospective review of 162 patients who underwent BSGI in BI-RADS 4 lesions on mammography and/or ultrasound. Results Of the 162 breast lesions, 66 were malignant tumors and 96 were benign tumors. Sensitivity and specificity of BSGI were 90.9% and 78.1%, and positive predictive value and negative predictive value were 74.1% and 92.6%. The sensitivity or specificity of mammography and ultrasound were 74.2% and 56.3% and 87.9% and 19.8%, respectively. The sensitivity and specificity of BSGI for breast lesions ≤1 cm were 88.0% and 86.8%, while the values of beast lesions >1 cm were 92.7% and 61.5%. The sensitivity or specificity of BSGI and mammography for patients with dense breasts were 92.0% and 81.3% and 72.0% and 50.0%, respectively. 26 patients showed neither a nodule nor microcalcification on ultrasound, but showed suspicious calcification on mammography. The sensitivity and specificity of BSGI with microcalcification only lesion were 75.0% and 94.4%. Conclusion This study demonstrated that BSGI had shown high sensitivity and specificity, as well as positive and negative predictive values in BI-RADS 4 lesions on ultrasound and/or mammography. BSGI showed excellent results in dense breasts, in lesions that are less than 1 cm in size and lesions with suspicious microcalcification only. PMID:27073789

  16. Clinical usefulness of breast-specific gamma imaging as an adjunct modality to mammography for diagnosis of breast cancer: a systemic review and meta-analysis

    International Nuclear Information System (INIS)

    The purpose of this study was to assess the diagnostic performance of breast-specific gamma imaging (BSGI) as an adjunct modality to mammography for detecting breast cancer. Comprehensive searches of MEDLINE (1984 to August 2012) and EMBASE (1994 to August 2012) were performed. A summary receiver operating characteristic curve (SROC) was constructed to summarize the overall test performance of BSGI. The sensitivities for detecting subcentimetre cancer and ductal carcinoma in situ (DCIS) were pooled. The potential of BSGI to complement mammography was also evaluated by identifying mammography-occult breast cancer. Analysis of the studies revealed that the overall validity estimates of BSGI in detecting breast cancer were as follows: sensitivity 95 % (95 % CI 93-96 %), specificity 80 % (95 % CI 78-82 %), positive likelihood ratio 4.63 (95 % CI 3.13-6.85), negative likelihood ratio 0.08 (95 % CI 0.05-0.14), and diagnostic odds ratio 56.67 (95 % CI 26.68-120.34). The area under the SROC was 0.9552 and the Q* point was 0.8977. The pooled sensitivities for detecting subcentimetre cancer and DCIS were 84 % (95 % CI 80-88 %) and 88 % (95 % CI 81-92 %), respectively. Among patients with normal mammography, 4 % were diagnosed with breast cancer by BSGI, and among those with mammography suggestive of malignancy or new biopsy-proven breast cancer, 6 % were diagnosed with additional cancers in the breast by BSGI. BSGI had a high diagnostic performance as an excellent adjunct modality to mammography for detecting breast cancer. The ability to identify subcentimetre cancer and DCIS was also high. (orig.)

  17. Clinical usefulness of breast-specific gamma imaging as an adjunct modality to mammography for diagnosis of breast cancer: a systemic review and meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yu.; Wei, Wei; Yang, Hua-Wei; Liu, Jian-Lun [Affiliated Cancer Hospital of Guangxi Medical University, Department of Breast Surgery of Guangxi Cancer Hospital, Nanning, Guangxi (China)

    2013-03-15

    The purpose of this study was to assess the diagnostic performance of breast-specific gamma imaging (BSGI) as an adjunct modality to mammography for detecting breast cancer. Comprehensive searches of MEDLINE (1984 to August 2012) and EMBASE (1994 to August 2012) were performed. A summary receiver operating characteristic curve (SROC) was constructed to summarize the overall test performance of BSGI. The sensitivities for detecting subcentimetre cancer and ductal carcinoma in situ (DCIS) were pooled. The potential of BSGI to complement mammography was also evaluated by identifying mammography-occult breast cancer. Analysis of the studies revealed that the overall validity estimates of BSGI in detecting breast cancer were as follows: sensitivity 95 % (95 % CI 93-96 %), specificity 80 % (95 % CI 78-82 %), positive likelihood ratio 4.63 (95 % CI 3.13-6.85), negative likelihood ratio 0.08 (95 % CI 0.05-0.14), and diagnostic odds ratio 56.67 (95 % CI 26.68-120.34). The area under the SROC was 0.9552 and the Q* point was 0.8977. The pooled sensitivities for detecting subcentimetre cancer and DCIS were 84 % (95 % CI 80-88 %) and 88 % (95 % CI 81-92 %), respectively. Among patients with normal mammography, 4 % were diagnosed with breast cancer by BSGI, and among those with mammography suggestive of malignancy or new biopsy-proven breast cancer, 6 % were diagnosed with additional cancers in the breast by BSGI. BSGI had a high diagnostic performance as an excellent adjunct modality to mammography for detecting breast cancer. The ability to identify subcentimetre cancer and DCIS was also high. (orig.)

  18. The use of a portable gamma camera for preoperative lymphatic mapping: a comparison with a conventional gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Vidal-Sicart, Sergi; Paredes, Pilar [Hospital Clinic Barcelona, Nuclear Medicine Department (CDIC), Barcelona (Spain); Institut d' Investigacio Biomedica Agusti Pi Sunyer (IDIBAPS), Barcelona (Spain); Vermeeren, Lenka; Valdes-Olmos, Renato A. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Nuclear Medicine Department, Amsterdam (Netherlands); Sola, Oriol [Hospital Clinic Barcelona, Nuclear Medicine Department (CDIC), Barcelona (Spain)

    2011-04-15

    Planar lymphoscintigraphy is routinely used for preoperative sentinel node visualization, but large gamma cameras are not always available. We evaluated the reproducibility of lymphatic mapping with a smaller and portable gamma camera. In two centres, 52 patients with breast cancer received preoperative lymphoscintigraphy with a conventional gamma camera with a field of view of 40 x 40 cm. Static anterior and lateral images were performed at 15 min, 2 h and 4 h after injection of the radiotracer ({sup 99m}Tc-nanocolloid). At 2 h after injection, anterior and oblique images were also performed with a portable gamma camera (Sentinella, Oncovision) positioned to obtain a field of view of 20 x 20 cm. Visualization of lymphatic drainage on conventional images and images with the portable device were compared for number of nodes depicted, their intensity and localization of sentinel nodes. The images performed with the conventional gamma camera depicted sentinel nodes in 94%, while the portable gamma camera showed drainage in 73%. There was however no significant difference in visualization between the two devices when a lead shield was used to mask the injection area in 43 patients (95 vs 88%, p = 0.25). Second-echelon nodes were visualized in 62% of the patients with the conventional gamma camera and in 29% of the cases with the portable gamma camera. Preoperative imaging with a portable gamma camera fitted with a pinhole collimator to obtain a field of view of 20 x 20 cm is able to depict sentinel nodes in 88% of the cases, if a lead shield is used to mask the injection site. This device may be useful in centres without the possibility to perform a preoperative image. (orig.)

  19. Design and tests of a portable mini gamma camera

    International Nuclear Information System (INIS)

    Design optimization, manufacturing, and tests, both laboratory and clinical, of a portable gamma camera for medical applications are presented. This camera, based on a continuous scintillation crystal and a position-sensitive photomultiplier tube, has an intrinsic spatial resolution of ≅2 mm, an energy resolution of 13% at 140 keV, and linearities of 0.28 mm (absolute) and 0.15 mm (differential), with a useful field of view of 4.6 cm diameter. Our camera can image small organs with high efficiency and so it can address the demand for devices of specific clinical applications like thyroid and sentinel node scintigraphy as well as scintimammography and radio-guided surgery. The main advantages of the gamma camera with respect to those previously reported in the literature are high portability, low cost, and weight (2 kg), with no significant loss of sensitivity and spatial resolution. All the electronic components are packed inside the minigamma camera, and no external electronic devices are required. The camera is only connected through the universal serial bus port to a portable personal computer (PC), where a specific software allows to control both the camera parameters and the measuring process, by displaying on the PC the acquired image on 'real time'. In this article, we present the camera and describe the procedures that have led us to choose its configuration. Laboratory and clinical tests are presented together with diagnostic capabilities of the gamma camera

  20. Centering mount for a gamma camera

    International Nuclear Information System (INIS)

    A device for centering a γ-camera detector in case of radionuclide diagnosis is described. It permits the use of available medical coaches instead of a table with a transparent top. The device can be used for centering a detector (when it is fixed at the low end of a γ-camera) on a required area of the patient's body

  1. Diagnostic performance of breast specific gamma imaging (BSGI) for breast cancer: Usefulness of dual phase imaging with 99mTc sestamibi

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the usefulness of breast specific gamma imaging (BSGI) with dual phase imaging for increasing diagnostic performance and interpreter confidence. We studied 76 consecutive patients (mean age: 49.3 years, range: 33-61 years) who received 925MBq (25mCi) 99mTc sestamibi intravenously. Craniocaudal and mediolateral oblique planar images were acquired for all patients. Delayed images were obtained from all patients 1h after tracer injection, except for patients with no definite abnormal uptake. All images were classified into four categories: group 1 (definite negative) = no definite abnormal uptake; group 2 (possible negative) = symmetrically diffuse and amorphous uptake; group 3 (possible positive) = asymmetrically mild and nodular uptake; group 4 (definite positive) = asymmetrically intense and nodular uptake. To evaluate diagnostic performance, the BSGI studies were classified as positive (group 3 or 4) or negative (group 1 or 2) for malignancy according to a visual analysis. The final diagnoses were derived from histopathological confirmation and/or imaging follow up after at least 6 months (range: 6-14 months) by both ultrasonography and mammography. The patients' ages ranged from 33 to 61 years, with an average of 49.3 years. Thirteen patients were diagnosed with malignancy, and 63 patients were diagnosed as negative for malignancy. Using early images, 43 patients were classified as group 1, 12 as group 2, 10 as group 3 and 11 as group 4. Based on early images, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of BSGI were 77%, 83%, 48%, 95% and 82%, respectively. Dual phase BSGI had a sensitivity, specificity, PPV, NPV and accuracy of 69%, 95%, 75%, significantly higher with dual phase imaging than with single phase imaging (p=0.0078), but the sensitivity did not differ significantly (p=1.0). Based on dual phase imaging, the sensitivity, specificity, positive

  2. Development and application of a small gamma camera

    Science.gov (United States)

    Matthews, Kenneth Lee, II

    This work investigates the design, construction, and application of a portable gamma camera based on a single position-sensitive photomultiplier tube (PSPMT) rather than an array of conventional photomultiplier tubes as used in the majority of gamma cameras. The PSPMT is an innovation in phototube design which allows two-dimensional (2-D) position information to be obtained from a single phototube. PSPMT-based portable gamma cameras can have several distinct advantages over portable systems using conventional technology: lower weight, reduced electronics, and smaller size. These advantages imply that PSPMT imagers can be more portable and possibly less expensive than their conventional counterparts. Additionally, this design can be incorporated as modules in conjugate imaging, orthogonal view, or ring detector systems, or even in conventional large-area planar imagers. The PSPMT design is applicable for diagnostic clinical procedures and for basic biomedical research. Clinically, this system could be used for intraoperative imaging; bedside imaging of non-transportable patients, e.g., in an intensive care unit, nursing home, or burn unit; and imaging in outpatient settings. In research settings such as radiopharmaceutical development laboratories, the PSPMT camera is suitable for imaging of small animals. The University of Chicago Small Gamma Camera (SGC) is a PSPMT-based gamma camera. Two SGC systems have been designed and constructed. Computer simulations and physical measurements have been applied to the performance characterization of the SGC. A maximum-likelihood position estimation scheme has been implemented in the system in place of the Anger position estimation scheme used in the majority of conventional gamma cameras. The SGC has been evaluated for several nuclear medicine imaging applications as well as laboratory research imaging. The clinical applications include planar and tomographic imaging. Radiotracer imaging with the SGC has been applied to the

  3. Spectroscopic gamma camera for use in high dose environments

    Science.gov (United States)

    Ueno, Yuichiro; Takahashi, Isao; Ishitsu, Takafumi; Tadokoro, Takahiro; Okada, Koichi; Nagumo, Yasushi; Fujishima, Yasutake; Kometani, Yutaka; Suzuki, Yasuhiko; Umegaki, Kikuo

    2016-06-01

    We developed a pinhole gamma camera to measure distributions of radioactive material contaminants and to identify radionuclides in extraordinarily high dose regions (1000 mSv/h). The developed gamma camera is characterized by: (1) tolerance for high dose rate environments; (2) high spatial and spectral resolution for identifying unknown contaminating sources; and (3) good usability for being carried on a robot and remotely controlled. These are achieved by using a compact pixelated detector module with CdTe semiconductors, efficient shielding, and a fine resolution pinhole collimator. The gamma camera weighs less than 100 kg, and its field of view is an 8 m square in the case of a distance of 10 m and its image is divided into 256 (16×16) pixels. From the laboratory test, we found the energy resolution at the 662 keV photopeak was 2.3% FWHM, which is enough to identify the radionuclides. We found that the count rate per background dose rate was 220 cps h/mSv and the maximum count rate was 300 kcps, so the maximum dose rate of the environment where the gamma camera can be operated was calculated as 1400 mSv/h. We investigated the reactor building of Unit 1 at the Fukushima Dai-ichi Nuclear Power Plant using the gamma camera and could identify the unknown contaminating source in the dose rate environment that was as high as 659 mSv/h.

  4. Effect of scatter media on small gamma camera imaging characteristics

    International Nuclear Information System (INIS)

    Effect of scatter media materials and thickness, located between radioactivity and small gamma camera, on imaging characteristics was evaluated. The small gamma camera developed for breast imaging was consisted of collimator, NaI(TI) crystal (60x60x6 mm3). PSPMT (position sensitive photomultiplier tube), NIMs and personal computer. Monte Carlo simulation was performed to evaluate the system sensitivity with different scatter media thickness (0∼8 cm) and materials (air and acrylie) with parallel hole collimator and diverging collimator. The sensitivity and spatial resolution was measured using the small gamma camera with the same condition applied to the simulation. Counts was decreased by 10% (air) and 54% (acrylic) with the parallel hole collimator and by 35% (air) and 63% (acrylic) with the diverging collimator. Spatial resolution was decreased as increasing the thickness of scatter media. This study substantiate the importance of a gamma camera positioning and the minimization of the distance between detector and target lesion in the clinical application of a gamma camera

  5. Development and evaluation of a Gamma Camera tuning system

    International Nuclear Information System (INIS)

    Correct operation of conventional analogue Gamma Cameras implies a good conformation of the position signals that correspond to a specific photo-peak of the radionuclide of interest. In order to achieve this goal the energy spectrum from each photo multiplier tube (PMT) has to be set within the same energy window. For this reason a reliable tuning system is an important part of all gamma cameras processing systems. In this work is being tested and evaluated a new prototype of tuning card that was developed and setting up for this purpose. The hardware and software of the circuit allow the regulation if each PMT high voltage. By this means a proper gain control for each of them is accomplished. The Tuning Card prototype was simulated in a virtual model and its satisfactory operation was proven in a Siemens Orbiter Gamma Camera. (Author)

  6. Latest developments in gamma-camera performance testing: resolution measurements

    International Nuclear Information System (INIS)

    Resolution for gamma cameras has two distinct aspects: spatial resolution, referring to the ability to image closely spaced point or line sources of radioactivity as separate entities; and temporal resolution, referring to the ability to properly register two events occurring within a very small time interval as separate events. The BRH Test Pattern has been proven to be a valuable tool for the evaluation of spatial resolution in a wide variety of gamma cameras. A reading from a transmission image of this pattern provides adequate accuracy (0.5 mm minimal separation) for determining intrinsic resolution, and for making an evaluation of spatial distortion and nonuniformities. This pattern can be used for acceptance testing of newly installed equipment and for quality control of all types of gamma cameras as well. Images taken weely may reveal changes in intrinsic resolution, field uniformity, and spatial distortion that may occur gradually over a period of time

  7. Iterative reconstruction of detector response of an Anger gamma camera.

    Science.gov (United States)

    Morozov, A; Solovov, V; Alves, F; Domingos, V; Martins, R; Neves, F; Chepel, V

    2015-05-21

    Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the photomultiplier tube light-response functions. Here we describe an iterative method which allows one to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the method for medical gamma cameras is demonstrated using both simulated and experimental data. An implementation of the iterative reconstruction technique capable of operating in real time is presented. We show that this technique can also be used for monitoring photomultiplier gain variations. PMID:25951792

  8. Iterative reconstruction of the detector response for medical gamma cameras

    CERN Document Server

    Morozov, A; Alves, F; Domingos, V; Martins, R; Neves, F; Chepel, V

    2015-01-01

    Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the PMT light response functions. Here we describe an iterative technique which allows to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the technique for medical gamma cameras is demonstrated using both simulated and experimental data. We show that this technique can be used for monitoring of the photomultiplier gain variations. An implementation of the iterative reconstruction technique capable of operating in real-time is also presented.

  9. Iterative reconstruction of detector response of an Anger gamma camera

    Science.gov (United States)

    Morozov, A.; Solovov, V.; Alves, F.; Domingos, V.; Martins, R.; Neves, F.; Chepel, V.

    2015-05-01

    Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the photomultiplier tube light-response functions. Here we describe an iterative method which allows one to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the method for medical gamma cameras is demonstrated using both simulated and experimental data. An implementation of the iterative reconstruction technique capable of operating in real time is presented. We show that this technique can also be used for monitoring photomultiplier gain variations.

  10. A detector for submillimeter gamma cameras

    International Nuclear Information System (INIS)

    Anger cameras (SPECT etc.) presently used in nuclear medicine employ as active detector NaI crystals, obtaining intrinsic spatial resolutions ≥3 mm. Arrays made of optically isolated single crystal elements of YAP:Ce, having sub-millimeter aperture size, read out by position sensitive photomultipliers, allow to build active detectors to employ in SPECT systems, with intrinsic spatial resolution below the millimeter, and with time resolution of the order of tens of nanoseconds. In this paper preliminary results of measurements carried out on different kinds of YAP:Ce arrays are reported. The measurements have been performed aiming to optimize the geometrical and physical parameters of the crystals in order to accomplish a SPEM (single photon emission mammography) camera detector. (orig.)

  11. Upgrade of the JET gamma-ray cameras

    International Nuclear Information System (INIS)

    Full text: The JET gamma-ray camera diagnostics have already provided valuable information on the gamma-ray imaging of fast ion in JET plasmas. The applicability of gamma-ray imaging to high performance deuterium and deuterium-tritium JET discharges is strongly dependent on the fulfilment of rather strict requirements for the characterisation of the neutron and gamma-ray radiation fields. These requirements have to be satisfied within very stringent boundary conditions for the design, such as the requirement of minimum impact on the co-existing neutron camera diagnostics. The JET Gamma-Ray Cameras (GRC) upgrade project deals with these issues with particular emphasis on the design of appropriate neutron/gamma-ray filters ('neutron attenuators'). Several design versions have been developed and evaluated for the JET GRC neutron attenuators at the conceptual design level. The main design parameter was the neutron attenuation factor. The two design solutions, that have been finally chosen and developed at the level of scheme design, consist of: a) one quasi-crescent shaped neutron attenuator (for the horizontal camera) and b) two quasi-trapezoid shaped neutron attenuators (for the vertical one). The second design solution has different attenuation lengths: a short version, to be used together with the horizontal attenuator for deuterium discharges, and a long version to be used for high performance deuterium and DT discharges. Various neutron-attenuating materials have been considered (lithium hydride with natural isotopic composition and 6Li enriched, light and heavy water, polyethylene). Pure light water was finally chosen as the attenuating material for the JET gamma-ray cameras. The neutron attenuators will be steered in and out of the detector line-of-sight by means of an electro-pneumatic steering and control system. The MCNP code was used for neutron and gamma ray transport in order to evaluate the effect of the neutron attenuators on the neutron field of the

  12. Miniature gamma-ray camera for tumor localization

    International Nuclear Information System (INIS)

    The overall goal of this LDRD project was to develop technology for a miniature gamma-ray camera for use in nuclear medicine. The camera will meet a need of the medical community for an improved means to image radio-pharmaceuticals in the body. In addition, this technology-with only slight modifications-should prove useful in applications requiring the monitoring and verification of special nuclear materials (SNMs). Utilization of the good energy resolution of mercuric iodide and cadmium zinc telluride detectors provides a means for rejecting scattered gamma-rays and improving the isotopic selectivity in gamma-ray images. The first year of this project involved fabrication and testing of a monolithic mercuric iodide and cadmium zinc telluride detector arrays and appropriate collimators/apertures. The second year of the program involved integration of the front-end detector module, pulse processing electronics, computer, software, and display

  13. ISPA - a high accuracy X-ray and gamma camera Exhibition LEPFest 2000

    CERN Multimedia

    2000-01-01

    ISPA offers ... Ten times better resolution than Anger cameras High efficiency single gamma counting Noise reduction by sensitivity to gamma energy ...for Single Photon Emission Computed Tomography (SPECT)

  14. An ISPA-camera for gamma rays

    CERN Document Server

    Puertolas, D; Pani, R; Leutz, H; Gys, Thierry; De Notaristefani, F; D'Ambrosio, C

    1995-01-01

    With the recently developed ISPA (Imaging Silicon Pixel Array)-tube attached either to a planar YAlO3(Ce) (YAP) disc (1mm thick) or to a matrix of optically-separated YAP-crystals (5mm high, 0.6 x 0.6 mm2 cross-section) we achieved high spatial resolution of 57Co-122 keV photons. The vacuum-sealed ISPA-tube is only 4 cm long with 3.5 cm diameter and consists of a photocathode viewed at 3 cm distance by a silicon pixel chip, directly detecting the photoelectrons. The chip-anode consists of 1024 rectangular pixels with 75 µm x 500 µm edges, each bump-bonded to their individual front-end electronics. The total pixel array read-out time is 10 µs. The measured intrinsic spatial resolutions (FWHM) of this ISPA-camera are 700 µm (planar YAP) and 310 µm (YAP-matrix). Apart from its already demonstrated application for particle tracking with scintillating fibres, the ISPA-tube provides also an excellent tool in medicine, biology and chemistry.

  15. Gamma camera investigations using an on-line computer system

    International Nuclear Information System (INIS)

    A computer system for use with a gamma camera has been developed by Oerebro Regional Hospital and Nukab AB using a PDP 8/e with a 12K core memory connected to a Selektronik gamma camera. It is possible to register, without loss, pictures of high (5kcps) pulse frequency, two separate channels with identical coordinates, fast dynamic functions down to 5 pictures/second, and to perform statistical smoothing and subtraction of two separate pictures. Experience has shown these possibilities to be so valuable that one has difficulty in thinking of a scanning system without them. This applies not only to sophisticated investigations, e.g. dual isotope registration, but also in conventional scanning for avoiding false positive interpretations and increasing the precision. It is possible at relatively low cost to add a dosage planning system. (JIW)

  16. Evaluation of efficiency of a semiconductor gamma camera

    CERN Document Server

    Otake, H; Takeuchi, Y

    2002-01-01

    We evaluation basic characteristics of a compact type semiconductor gamma camera (eZ-SCOPE AN) of Cadmium Zinc Telluride (CdZnTe). This new compact gamma camera has 256 semiconductors representing the same number of pixels. Each semiconductor is 2 mm square and is located in 16 lines and rows on the surface of the detector. The specific performance characteristics were evaluated in the study referring to National Electrical Manufactures Association (NEMA) standards; intrinsic energy resolution, intrinsic count rate performance, integral uniformity, system planar sensitivity, system spatial resolution, and noise to the neighboring pixels. The intrinsic energy resolution measured 5.7% as full width half maximum (FWHM). The intrinsic count rate performance ranging from 17 kcps to 1,285 kcps was evaluated, but the highest intrinsic count rate was not observed. Twenty percents count loss was recognized at 1,021 kcps. The integral uniformity was 1.3% with high sensitivity collimator. The system planar sensitivity w...

  17. Acquisition of gamma camera and physiological data by computer

    International Nuclear Information System (INIS)

    We have designed, implemented, and tested a new Research Data Acquisition System (RDAS) that permits a general purpose digital computer to acquire signals from both gamma camera sources and physiological signal sources concurrently. This system overcomes the limited multi-source, high speed data acquisition capabilities found in most clinically oriented nuclear medicine computers. The RDAS can simultaneously input signals from up to four gamma camera sources with a throughput of 200 kHz per source and from up to eight physiological signal sources with an aggregate throughput of 50 kHz. Rigorous testing has found the RDAS to exhibit acceptable linearity and timing characteristics. In addition, flood images obtained by this system were compared with flood images acquired by a commercial nuclear medicine computer system. National Electrical Manufacturers Association performance standards of the flood images were found to be comparable

  18. Silicon drift photodetector arrays for the HICAM gamma camera

    International Nuclear Information System (INIS)

    Silicon drift detectors (SDDs) have shown to be a competitive device for the readout of scintillators with respect to conventional photodetectors, thanks to their high quantum efficiency and low electronics noise. Recently, they have been successfully employed in first small prototypes of Anger cameras to achieve sub-millimeter spatial resolution in gamma-ray imaging. To cover larger formats of Anger cameras, in particular in the framework of the HICAM project, specially focused on human imaging, we have developed new SDD arrays of larger active areas. To assemble photodetector planes of several cm2, we have designed a basic unit composed by a linear array of 5 SDDs of 1 cm2 active area each. In this work, we present the results of the experimental characterization of these photodetector arrays in direct X-ray detection to evaluate the electronics noise, as well as gamma-ray detection with a scintillator.

  19. Monitoring rotating gamma camera performance for emission tomography

    International Nuclear Information System (INIS)

    The procedure for assessing and correcting the uniformity of the gamma camera image in emission tomography is briefly outlined. The gantry condition is another parameter affecting the tomographic image. Centre of rotation calibration data are presented to illustrate the gantry checking procedure and to show how faults can be diagnosed from the data. A calibration procedure for checking the alignment of the X, Y image axis with the axis of rotation is also briefly described. (U.K.)

  20. Portable gamma camera for clinical use in nuclear medicine

    International Nuclear Information System (INIS)

    Up today Hamamatsu R3292 is the Position Sensitive Photo Multiplier Tube (PSPMT) with the largest sensitive area (10 cm of diameter). At the same time it has the minimum size for clinical application in Nuclear Medicine. A portable gamma camera was realized, based on 5 inches PSPMT coupled to a scintillating array. The head has a light weight (15 Kg.) spatial resolution resulted better than that of Anger Camera with good linearity response, good energy resolution and FOV coincident with intrinsic one of PSPMT. To optimize gamma camera response two different scintillating arrays were tested: YAP:Ce and CsI (Tl). Their overall size cover all photochatode active area, and crystal pixel size was 2 mm x 2 mm. The detection efficiency resulted comparable to that of Anger Camera. The best result was obtained by CsI (Tl) scintillating: an intrinsic spatial resolution of 1.6 mm FWHM and a relative energy resolution of 17% FWHM. With a standard general purpose collimator a spatial resolution of about 2 mm resulted. Some preliminary results were also obtained in breast scintigraphy

  1. Measurement of the performance of the gamma camera oscilloscope display

    International Nuclear Information System (INIS)

    In one common type of gamma camera display system, the positions at which the gamma photons are detected in the scintillation crystal are correlated with flashes on the face of a cathode-ray tube. A permanent record is obtained by integrating these flashes on a photographic film. There are problems in assessing the performance of the display system, since the photographic film is a non-linear recording medium, and the gamma camera itself does not always give the correct spatial position of each detected gamma photon. A computer simulation of the display has therefore been used to assess the best possible performance of the display system. The simulated test pattern represented a uniform background distribution of radioisotope on which was superimposed a circular disc of increased radioactivity. The target was imaged so as to have a rectangular count-density profile. Studies of the interaction between the display and different observers showed that an increase in the total number of background counts decreased the detection contrast. The results are compared with predictions from statistical theories. (U.K.)

  2. FDG-PET using coincidence gamma cameras - an update

    International Nuclear Information System (INIS)

    PET imaging with F-18 labeled tracers - mainly FDG - is on the verge to be applied in a broad clinical setting with a multitude of indications in oncology, neurology and cardiology. Main obstacles for a more widespread distribution of PET technology are the high costs of cyclotron products (350-500 Euro for FDG in satellite distribution) and of dedicated PET tomographs (1.5 Mio Euro). As a consequence, dual head gamma cameras were equipped for coincidence detection and tested as 'small PET'. Meanwhile a few studies have been published allowing a new evaluation of coincidence gamma cameras for FDG imaging. Decisive criteria should be the better diagnostic performance in comparison with CT and MRI. Applying restrictive indications these systems might be useful for staging head and neck tumors, and for evaluation of solitary pulmonary nodules larger than 1 cm. In the future, the option for camera PET most likely will be the control of ongoing therapy of known lesions (chemo- or radiotherapy). (orig.)

  3. Multichannel spectrum analysis for a gamma-ray imaging camera

    International Nuclear Information System (INIS)

    The US Department of Energy's robotics for nuclear reactors programs include the development of a gamma-ray imaging camera to locate and identify radiation fields typical of commercial reactor environments. The raster scanning camera is a lead-shielded bismuth germanate scintillator coupled to a photomultiplier tube operated in pulse mode. The camera is mounted on a rotating, tilting platform to allow two-dimensional scanning and requires a movable shutter to subtract background radiation. While previous work produced monochromatic images, this paper discusses colored images now available through a multichannel spectrum analysis at each pixel location, and typical images are shown. Scanning operation is controlled by a personal computer-based system with an independent multichannel analyzer (MCA) board that allows for near-real-time spectrum analysis of a pixel position while the following position is being measured. The controlling routine operates the camera tilt, rotation, and shutter movement; acquires data from the MCA; and calls the peak search analysis routine

  4. Upgrading of analogue gamma cameras with PC based computer system

    International Nuclear Information System (INIS)

    Full text: Dedicated nuclear medicine computers for acquisition and processing of images from analogue gamma cameras in developing countries are in many cases faulty and technologically obsolete. The aim of the upgrading project of International Atomic Energy Agency (IAEA) was to support the development of the PC based computer system which would cost 5.000 $ in total. Several research institutions from different countries (China, Cuba, India and Slovenia) were financially supported in this development. The basic demands for the system were: one acquisition card an ISA bus, image resolution up to 256x256, SVGA graphics, low count loss at high count rates, standard acquisition and clinical protocols incorporated in PIP (Portable Image Processing), on-line energy and uniformity correction, graphic printing and networking. The most functionally stable acquisition system tested on several international workshops and university clinics was the Slovenian one with a complete set of acquisition and clinical protocols, transfer of scintigraphic data from acquisition card to PC through PORT, count loss less than 1 % at count rate of 120 kc/s, improvement of integral uniformity index by a factor of 3-5 times, reporting, networking and archiving solutions for simple MS network or server oriented network systems (NT server, etc). More than 300 gamma cameras in 52 countries were digitized and put in the routine work. The project of upgrading the analogue gamma cameras yielded a high promotion of nuclear medicine in the developing countries by replacing the old computer systems, improving the technological knowledge of end users on workshops and training courses and lowering the maintenance cost of the departments. (author)

  5. Development of Active Pixel Photodiode Sensors for Gamma Camera Application

    CERN Document Server

    Salahuddin, Nur Sultan; Heruseto, Brahmantyo; Parmentier, Michel

    2011-01-01

    We designed new photodiodes sensors including current mirror amplifiers. These photodiodes have been fabricated using a CMOS 0.6 micrometers process from Austria Micro System (AMS). The Photodiode areas are respectiveley 1mm x 1mm and 0.4mm x 0.4mm with fill factor 98 % and total chip area is 2 square millimetres. The sensor pixels show a logarithmic response in illumination and are capable of detecting very low blue light (less than 0.5 lux) . These results allow to use our sensor in new Gamma Camera solid-state concept.

  6. Monte Carlo simulation for dual head gamma camera

    International Nuclear Information System (INIS)

    Monte Carlo (MC) simulation technique was used widely in medical physics applications. In nuclear medicine MC was used to design new medical imaging devices such as positron emission tomography (PET), gamma camera and single photon emission computed tomography (SPECT). Also it can be used to study the factors affecting image quality and internal dosimetry, Gate is on of monte Carlo code that has a number of advantages for simulation of SPECT and PET. There is a limit accessibilities in machines which are used in clinics because of the work load of machines. This makes it hard to evaluate some factors effecting machine performance which must be evaluated routinely. Also because of difficulties of carrying out scientific research and training of students, MC model can be optimum solution for the problem. The aim of this study was to use gate monte Carlo code to model Nucline spirit, medico dual head gamma camera hosted in radiation and isotopes center of Khartoum which is equipped with low energy general purpose LEGP collimators. This was used model to evaluate spatial resolution and sensitivity which is important factor affecting image quality and to demonstrate the validity of gate by comparing experimental results with simulation results on spatial resolution. The gate model of Nuclide spirit, medico dual head gamma camera was developed by applying manufacturer specifications. Then simulation was run. In evaluation of spatial resolution the FWHM was calculated from image profile of line source of Tc 99m gammas emitter of energy 140 KeV at different distances from modeled camera head at 5,10,15,20,22,27,32,37 cm and for these distances the spatial resolution was founded to be 5.76, 7.73, 10.7, 13.8, 14.01,16.91, 19.75 and 21.9 mm, respectively. These results showed a decrement of spatial resolution with increase of the distance between object (line source) and collimator in linear manner. FWHM calculated at 10 cm was compared with experimental results. The

  7. Technetium 99m mercaptoacetyltriglycine gamma camera clearance calculations: Methodological problems

    International Nuclear Information System (INIS)

    Major sources of errors in the gamma-camera methods for the calculation of renal clearance are the accuracy of background correction for obtaining the true renal time-activity curve and the validity of the externally recorded pre-cordial activity as an estimate of the plasmatic time-activity curve. With technetium 99m mercaptoacetyltriglycine (99mTc-MAG3), because of its high protein plasma binding, one could expect minimal extravascular diffusion and hence a more accurate externally detected plasmatic curve. The high extraction rate should reduce the influence of the background, but, on the other hand, the effect of hepatobiliary excretion on the calculation of renal clearance might be significant. Our results suggest that the hepatobiliary excretion of 99mTc-MAG3 does not influence the gamma-camera renal clearance determination, even in patients with low renal function. However, the pre-cordial curve does not reflect accurately the plasmatic disappearance curve; its calibration with a single plasma sample taken at the 20th min is responsible for significant errors, probably because of an unfavourable ratio between the intravascular and extravascular activities at the 20th min. (orig.)

  8. Quality assurance of gamma camera scintigraphy in Sweden

    International Nuclear Information System (INIS)

    This nationwide quality assurance project was undertaken during 1990. In total 81 cameras were checked. The mean age for the gamma cameras was 6.5±4.9 years, with the oldest one being 16 years. The uniformity and the spatial resolution of each camera were checked with a flood field and a bar fantom and for the 35 cameras dedicated and used for SPECT, the tomographic uniformity and the adjustment to the axis of rotation were explored with a cylindrical phantom and with a line source, respectively. The intercomparison of bone scintigraphy was performed with a novel transmission skeleton phantom with 18 simulated defects in the ribs and in the vertebrae. The number of counts in the images ranged from 0.16 to 1.1 million with a mean of 0.7 million counts. The local interpreters had been asked to make an assessment of 'their' skeleton images according to a specific protocol. The results can be summarised as follows: One third of the camera systems was classified as having inferior properties for planar imaging in general. For the SPECT system the adjustment of the center of the acquisition matrix to the radius of rotations was found to be adequate. The results from the skeleton study demonstrated considerable variation with the true positives (TP) ranging from 5 to 16 and the false positives (FP) ranging from 0 to 10. The average TP and FP of all 68 interpretations were 11.1 and 1.0, respectively. Due to the large variation of the detection rates, it was not possible to demonstrate clear relationships between the number of true positive findings of the individual interpreters and the camera quality indicators. From these results we concluded that the number of recorded events in a PA projection of the thoracic skeleton should exceed 800 000, and that the overall spatial resolution of the system has a clear impact on the detectability of small and low 'abnormal' uptakes. The image presentation system for hard-copies is crucial for high image quality. The videoscreen

  9. New gamma cameras in nuclear cardiology: D-SPECT; Les nouvelles gamma cameras en cardiologie nucleaire: D-Spect

    Energy Technology Data Exchange (ETDEWEB)

    Rouzet, F.; Bechara, T.; Ben Ali, K.; Nassar, P.; Grellier, J.F.; Burg, S.; Hyafil, F.; Le Guludec, D. [Service de medecine nucleaire, groupe hospitalier Bichat-Claude-Bernard, AP-HP, 75 - Paris (France)

    2010-08-15

    Over the past few years, advances in nuclear medicine aimed at decreasing both the duration and dosimetry of exams, without decreasing image quality. In this setting, Spectrum Dynamics (D-Spect) is a new generation gamma camera dedicated to cardiac scintigraphy. Its technology includes solid-state detectors based on pixelated semiconductors, region-centric (cardiac area) scanning, high-sensitivity collimators and resolution recovery. An additional particularity is the patient position during scanning. Phantom studies showed an improvement of sensitivity compared to conventional cameras, at the price of a loss in geometric resolution, which is compensated by resolution recovery. Semiconductors detectors provide a better energy resolution than conventional detectors suited to double isotope acquisitions, and a high count rate allowing dynamic acquisitions. Only few clinical studies are available so far, they suggest performances similar to that of conventional cameras obtained with acquisitions duration reduced to few minutes. The next step is to establish a trade-off between acquisition duration and dosimetry reduction. (authors)

  10. High count rate gamma camera with independent modules

    Science.gov (United States)

    Massari, R.; Ucci, A.; Campisi, C.; Scopinaro, F.; Soluri, A.

    2015-11-01

    Advances in nuclear medical imaging are based on the improvements of the detector's performance. Generally the research is focussed on the spatial resolution improvement. However, another important parameter is the acquisition time that can significantly affect performance in some clinical investigation (e.g. first-pass cardiac studies). At present, there are several clinical imaging systems which are able to solve these diagnostic requirements, such as the D-SPECT Cardiac Imaging System (Spectrum Dynamics) or the Nucline Cardiodesk Medical Imaging System (Mediso). Actually, these solutions are organ-specific dedicated systems, while it would be preferable having general purpose planar detectors with high counting rate. Our group has recently introduced the use of scintillation matrices whose size is equal to the overall area of a position sensitive photomultiplier tube (PSPMT) in order to design a modular gamma camera. This study allowed optimising the overall pixel identification by improving and controlling the light collection efficiency of each PSPMT. Although we achieved a solution for the problems about the dead area at the junction of the PSPMTs when they are set side by side. In this paper, we propose a modular gamma camera design as the basis to build large area detectors. The modular detector design allows us to achieve better counting performance. In this approach, each module that is made of one or more PSPMTs, can actually acquire data independently and simultaneously, increasing the overall detection efficiency. To verify the improvement in count rate capability we have built two detectors with a field of view of ~ 5 × 5cm2, by using four R8900-C12 PSPMTs (Hamamatsu Photonics K.K.). Each PSPMT was coupled to a dedicated discrete scintillation structure designed to obtain a good homogeneity, high imaging performance and high efficiency. One of the detectors was designed as a standard gamma camera, while the other was composed by four independent

  11. Coded-aperture Compton camera for gamma-ray imaging

    Science.gov (United States)

    Farber, Aaron M.

    This dissertation describes the development of a novel gamma-ray imaging system concept and presents results from Monte Carlo simulations of the new design. Current designs for large field-of-view gamma cameras suitable for homeland security applications implement either a coded aperture or a Compton scattering geometry to image a gamma-ray source. Both of these systems require large, expensive position-sensitive detectors in order to work effectively. By combining characteristics of both of these systems, a new design can be implemented that does not require such expensive detectors and that can be scaled down to a portable size. This new system has significant promise in homeland security, astronomy, botany and other fields, while future iterations may prove useful in medical imaging, other biological sciences and other areas, such as non-destructive testing. A proof-of-principle study of the new gamma-ray imaging system has been performed by Monte Carlo simulation. Various reconstruction methods have been explored and compared. General-Purpose Graphics-Processor-Unit (GPGPU) computation has also been incorporated. The resulting code is a primary design tool for exploring variables such as detector spacing, material selection and thickness and pixel geometry. The advancement of the system from a simple 1-dimensional simulation to a full 3-dimensional model is described. Methods of image reconstruction are discussed and results of simulations consisting of both a 4 x 4 and a 16 x 16 object space mesh have been presented. A discussion of the limitations and potential areas of further study is also presented.

  12. Nuclear medicine gamma camera system PRISM-XP series

    International Nuclear Information System (INIS)

    Recently, SPECT gamma camera systems have become important in RI imaging of the brain and torso. The PRISM-XP series is a new SPECT system which employs multiple detectors, a fan beam collimator and a non-circular orbit for improved acquisition speed and sensitivity. For improved data processing, this machine uses a 64-bit CPU and a 3D graphics subsystem specially designed for image processing. The PRISM-XP series also includes 3-detector, 2-detector and 1-detector systems. The dual and single detector systems also have functions for whole-body imaging. In this article, the PRISM-XP series, which is commercialized by PICKER International Inc, Ohio, U.S.A., is presented. (author)

  13. A new gamma camera for positron emission tomography

    International Nuclear Information System (INIS)

    This thesis describes the detection of annihiliation radiation employing a new principle: radiation is absorbed in a barium fluoride (BaF 2) crystal and the resulting scintillation light is detected in a multiwire proportional chamber filled with a photsensitive vapour. The application of such a detector for PET is new; the use of a high density fast scintillator in combination with a low pressure wire chamber offers a good detection efficiency and permits high count rates because of the small dead time. In this work, the physical background of the above detection mechanism is explored and the performance parameters of a gamma camera using this new principle, are determined. Furthermore, a comprehensive research on the scintillation mechanism and physical characteristics of the increasingly popular BaF 2 scintillator is presented. Also, a new class of ultraviolet (UV) scintillation materials, consisting of rare earth doped fluorides, is introduced. (author). 211 refs.; 30 figs.; 17 tabs

  14. Sensitivity comparative study in Philips Forte Gamma Camera

    International Nuclear Information System (INIS)

    Monte Carlo modeling is widely used in the development nuclear medical imaging systems, particularly in the adjustment of its main characteristics and parameters. It is essential to evaluate the behavior of the system sensitivity in real measurement conditions for specific patient. Planar studies of thyroid phantom were conducted in a Philips Forte Gamma Camera of the 'Hermanos Ameijeiras' Hospital. Experimental set up was totally reproduced in the simulation environment. A comparative study between the experimental and theoretical, obtained by Monte Carlo mathematical modeling, sensitivity values have been done. For simulation GAMOS (Geant4-Architecture for medicine Oriented Simulation) framework was used. The results obtained from both methods have shown an acceptable coincidence (less than 2%) of sensitivity. Therefore this paper aims to validate sensitivity studies carried out via Monte Carlo mathematical modeling and irs acceptable equivalence with experimental measurements in authentic medical circumstances. (Author)

  15. Swiss requirements concerning gamma camera acceptance and status testing

    International Nuclear Information System (INIS)

    Like in the field of radiology, digital systems are also becoming the standard in the field of nuclear medicine. This offers not only the possibility to process, transmit and archive data from patients more easily but also to introduce quantitative measurements for quality controls. In this framework standards concerning the qualification of gamma camera systems have been updated and appeared to be useful to set legal requirements, in spite of the fact that this is not their goal. The aim of this study was first to choose a set of tests described in standards to define measurements to be performed at the acceptance of the systems, after the regular maintenances (at least once every six months; status test) and for assuring the stability of the systems. To verify the feasibility, from the point of view of technical and a time requirements, the quality assurance programme proposed has been applied on three gamma camera systems. The results of this study show that, based on international standards, new requirements concerning the quality assurance of the gamma camera of the Swiss Public Health Authority make it necessary to slightly modify some procedures to reduce the time required for the acceptance and status tests. In the Ordinance related to the use of unsealed radioactive sources (November 1997) the Swiss Public Health Authority requires the supplier to carry out a reception test on all imaging devices used in the field of nuclear medicine before they can be used on patients. Moreover, a maintenance procedure of the imaging device has to be performed at least every six months by properly trained staff. This maintenance has to be followed by a status test that assures the integrity of the system before it can be used for further clinical applications. Daily and weekly stability tests, under the responsibility of the users of the system, are also defined. According to the Swiss Ordinance, all the measurements required for the acceptance and status tests should

  16. Comparative studies on scintigraphic examination of the thyroid gland with gamma-camera and scintiscanner

    International Nuclear Information System (INIS)

    Scintigraphic examination of the thyroid can be effected with the gamma-camera without entailing any loss of diagnostic information if a special parallel-hole collimator is used. An additional advantage offered by the gamma-camera is the possibility of employing EDV image processing techniques and of quantitative evaluation of the scintigram. (orig.)

  17. Quality control evaluation of 'Gamma PF' interfaces performance for gamma cameras upgrading according to the IAEA TECDOC 602/S tests

    International Nuclear Information System (INIS)

    Aim: The International Atomic Energy Agency (IAEA) had developed a model project around the world in order to support the upgrading of old Gamma cameras, connecting them with modern PC computers through interfaces with image improving capabilities. The aim of this work was to evaluate the performance of 'Gamma PF' interfaces, installed in local area network, using the TECDOC 602/S Quality Control Tests. Materials and Methods: 3 interfaces were used. 2 of them working for count uniformity and energy corrections and other with only count uniformity correction. All of them were Gamma Camera Interface Card Gamma PF - version 97./, which country of origin is Slovenia. 3 Gamma cameras were used, Picker Dyna 415, Picker 312-C and Ohio Nuclear Sigma 410. One Server and four Olidata Computers were used, three of them were connected to the gamma cameras and the other was used for image processing workstation. The tests for evaluating gamma camera-computer system described in the TECDOC 602/S from IAEA were used. Results: A significant improvement in the field uniformity of all gamma cameras was obtained with the online correction system of interfaces. No effect was observed on Resolution. With bar phantoms the visualization is increased though the resolution didn't change. The count rate tests showed an important loss of count using the interfaces. This evaluation is congruent with the observations found in test for checking acquisition times, in static and dynamic modalities. There was no change in the evaluation of linearity. Conclusion: The interfaces were most powerful utility in the correction of uniformity of gamma camera fields, showing limited performance in other evaluation tests like resolution and linearity. The design and performance of these gamma cameras should be done in order to improve the management of counting loss and their system for static and dynamic acquisitions

  18. Development of NEMA-based Software for Gamma Camera Quality Control

    OpenAIRE

    Rova, Andrew; Celler, Anna; Hamarneh, Ghassan

    2007-01-01

    We have developed a cross-platform software application that implements all of the basic standardized nuclear medicine scintillation camera quality control analyses, thus serving as an independent complement to camera manufacturers’ software. Our application allows direct comparison of data and statistics from different cameras through its ability to uniformly analyze a range of file types. The program has been tested using multiple gamma cameras, and its results agree with comparable analysi...

  19. NEMA NU-1 2007 based and independent quality control software for gamma cameras and SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Vickery, A [Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital (Denmark); Joergensen, T [Department of Clinical Physiology and Nuclear Medicine, Naestved Hospital (Denmark); De Nijs, R, E-mail: anette@vickery.dk [Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital (Denmark)

    2011-09-23

    A thorough quality assurance of gamma and SPECT cameras requires a careful handling of the measured quality control (QC) data. Most gamma camera manufacturers provide the users with camera specific QC Software. This QC software is indeed a useful tool for the following of day-to-day performance of a single camera. However, when it comes to objective performance comparison of different gamma cameras and a deeper understanding of the calculated numbers, the use of camera specific QC software without access to the source code is rather avoided. Calculations and definitions might differ, and manufacturer independent standardized results are preferred. Based upon the NEMA Standards Publication NU 1-2007, we have developed a suite of easy-to-use data handling software for processing acquired QC data providing the user with instructive images and text files with the results.

  20. PET imaging using gamma camera systems: a review.

    Science.gov (United States)

    Jarritt, P H; Acton, P D

    1996-09-01

    Optimized positron emission tomographs have begun to demonstrate an ever widening range of clinical applications for positron labelled pharmaceuticals. This potential has led to a renewed interest in the use of the more widely available Anger gamma camera detectors for imaging the 511 keV photons from the positron decay process. Two forms of detection can be considered: either the detection of the 511 keV photons as single events or the detection of coincidence events from the opposed pair annihilation photons. The widespread availability of dual, opposed-pair, large field-of-view detectors has promoted the development of coincidence detection without collimation. With detector rotation, positron emission tomography (PET) can be performed. An alternative and lower cost option has been the universal development of ultra high-energy collimators to perform single photon emission tomography (SPET) with 511 keV photons. This review outlines the currently available performance characteristics of these two approaches and compares them with those from two- and three-dimensional PET optimized systems. The limitations on the development of these systems is discussed through the analysis of the principles underlying both single photon and coincidence detection. Preliminary clinical experience indicates that limitations in the performance characteristics of these systems has implications for their potential role, although applications in cardiology and oncology are being pursued. PMID:8895903

  1. Principle of some gamma cameras (efficiencies, limitations, development)

    International Nuclear Information System (INIS)

    The quality of scintigraphic images is shown to depend on the efficiency of both the input collimator and the detector. Methods are described by which the quality of these images may be improved by adaptations to either the collimator (Fresnel zone camera, Compton effect camera) or the detector (Anger camera, image amplification camera). The Anger camera and image amplification camera are at present the two main instruments whereby acceptable space and energy resolutions may be obtained. A theoretical comparative study of their efficiencies is carried out, independently of their technological differences, after which the instruments designed or under study at the LETI are presented: these include the image amplification camera, the electron amplifier tube camera using a semi-conductor target CdTe and HgI2 detector

  2. Prototype gamma-camera system with CdZnTe semiconductor detectors

    International Nuclear Information System (INIS)

    The CdZnTe semiconductor detector, which works at room temperature, may lead to the development of next-generation gamma-camera systems due to its high spatial resolution and high energy resolution. We fabricated a prototype gamma-camera system with CdZnTe detectors to evaluate the feasibility of such a semiconductor gamma-camera. An energy resolution of 7.35% full width half maximum (FWHM) (at 140 keV) and an intrinsic spatial resolution of 1.8 mm FWHM were achieved. Single photon emission computed tomography (SPECT) images acquired using this gamma-camera system showed that the system can resolve hot and cold rods with a diameter of 3 mm. (author)

  3. Use of a personal computer to measure gamma camera spatial resolution

    International Nuclear Information System (INIS)

    A low-cost 1024-channel multichannel analyser (MCA) for γ-ray spectrometry, interfaced to a personal computer, has been adapted to measure the LSF of a γ-camera and calculate the FWHM with sufficient accuracy (sampling frequency better than 0.4 mm). The equipment described has been used on three gamma cameras in routine use. (author)

  4. Development of a high resolution gamma camera system using finely grooved GAGG scintillator

    Science.gov (United States)

    Yamamoto, Seiichi; Kataoka, Jun; Oshima, Tsubasa; Ogata, Yoshimune; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Hatazawa, Jun

    2016-06-01

    High resolution gamma cameras require small pixel scintillator blocks with high light output. However, manufacturing a small pixel scintillator block is difficult when the pixel size becomes small. To solve this limitation, we developed a high resolution gamma camera system using a finely grooved Ce-doped Gd3Al2Ga3O12 (GAGG) plate. Our gamma camera's detector consists of a 1-mm-thick finely grooved GAGG plate that is optically coupled to a 1-in. position sensitive photomultiplier tube (PSPMT). The grooved GAGG plate has 0.2×0.2 mm pixels with 0.05-mm wide slits (between the pixels) that were manufactured using a dicing saw. We used a Hamamatsu PSPMT with a 1-in. square high quantum efficiency (HQE) PSPMT (R8900-100-C12). The energy resolution for the Co-57 gamma photons (122 keV) was 18.5% FWHM. The intrinsic spatial resolution was estimated to be 0.7-mm FWHM. With a 0.5-mm diameter pinhole collimator mounted to its front, we achieved a high resolution, small field-of-view gamma camera. The system spatial resolution for the Co-57 gamma photons was 1.0-mm FWHM, and the sensitivity was 0.0025%, 10 mm from the collimator surface. The Tc-99m HMDP administered mouse images showed the fine structures of the mouse body's parts. Our developed high resolution small pixel GAGG gamma camera is promising for such small animal imaging.

  5. Positron emission tomography with gamma camera in coincidence mode

    International Nuclear Information System (INIS)

    Positron emission tomography using F-18 FDG has been estbalished in clinical diagnostics with first indications especially in oncology. To install a conventional PET tomography (dedicated PET) is financially costly and restricted to PET examinations only. Increasing demand for PET diagnostics on one hand and restricted financial resources in the health system on the other hand led industry to develop SPECT cameras to be operated in coincidence mode (camera PET) in order to offer nuclear medicine physicians cost-effective devices for PET diagnostic. At the same time camera PET is inferior to conventional PET regarding sensitivity and detection-efficiency for 511 keV photons. Does camera-PET offer a reliable alternative to conventional PET? The first larger comparative studies are now available, so a first apraisal about the technical clinical performance of camera-PET can be done. (orig.)

  6. Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras

    DEFF Research Database (Denmark)

    Jensen, Maria Maj; Schmidt, Ulla; Huang, Chenxi;

    2014-01-01

    of agreement between each sequence of analyses for each of the three cameras. RESULTS: The lowest intraobserver variations in LVEF for the two NaI-detector cameras were 3.1% (-4.0% to 3.5%) for the planar and 3.4% (-4.2% to 4.5%) for SPECT (P ≤ 0.001-0.019), the highest result for the CZT SPECT camera was 2.......6% (-2.9% to 3.1%). Similarly, interobserver variation was 4.8% (-4.8% to 6.4%) and 4.9% (-5.4% to 7.5%), respectively, for each of the NaI-detector cameras and 3.3% (-3.4% to 4.3%) for the CZT SPECT camera (P ≤ 0.001-0.008). DISCUSSION: The CZT detector camera was superior to both NaI detector cameras...... regarding intra- and interobserver variation. The CZT SPECT camera may identify changes in LVEF with greater certainty than its NaI detector-equipped counterparts....

  7. 乳腺专用伽马成像在乳腺癌诊断中的意义%Clinical significance of breast-specific gamma imaging in diagnosis of breast cancer

    Institute of Scientific and Technical Information of China (English)

    杨为戈; 石洪成; 谭辉; 王红; 朱玮; 杨子昂; 张宏伟

    2014-01-01

    Objective To evaluate the clinical significance of breast-specific gamma imaging ( BSGI) in diagnosis of breast cancer .Methods We performed a perspective study of 136 patients with indeterminate breast lesions who underwent dual-phase BSGI in our hospital from March 2012 to December 2013 .All included lesions were confirmed by pathology .BSGI was evaluated based on the visual interpretation and dual -phase semi-quantitative indices of lesion to non-lesion ( L/N) ratio, which were compared with pathological results . Difference of L/N ratio of BSGI between benign and malignant breast lesions was analyzed by Mann -Whitney U nonparametric test.Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of BSGI in the diagnosis of breast cancer were 95.1%( 97/102 ) , 73.5%( 25/34 ) , 89.7%(122/136), 91.5%(97/106) and 83.3%(25/30), respectively.L/N ratio of BSGI in breast cancer was significantly higher than that of benign tumor ( 2.98 ±1.29 vs 0.95 ±1.11 , Z=-7.125 , P=0.000 ) . Conclusion BSGI has a significant clinical value in the diagnosis of breast cancer .%目的:探讨乳腺专用伽马成像( BSGI)在乳腺癌诊断中的意义。方法对2012年3月至2013年12月本院收治的136例体格检查发现或偶然发现乳腺肿块、拟行手术的女性患者进行前瞻性研究,检测BSGI高低浓聚值比,并将BSGI结果与病理结果进行对比。采用Mann-Whitney U非参数检验分析良、恶性肿瘤之间BSGI高低浓聚值比的差异。结果 BSGI诊断乳腺癌的灵敏度、特异度、准确性、阳性预测值和阴性预测值分别为95.1%(97/102)、73.5%(25/34)、89.7%(122/136)、91.5%(97/106)、83.3%(25/30)。乳腺癌的 BSGI 高低浓聚值比明显高于良性肿瘤(2.98±1.29比0.95±1.11,Z=-7.125,P=0.000)。结论 BSGI对于乳腺癌的诊断具有很好的临床应用价值。

  8. Online gamma-camera imaging of 103Pd seeds (OGIPS) for permanent breast seed implantation

    International Nuclear Information System (INIS)

    Permanent brachytherapy seed implantation is being investigated as a mode of accelerated partial breast irradiation for early stage breast cancer patients. Currently, the seeds are poorly visualized during the procedure making it difficult to perform a real-time correction of the implantation if required. The objective was to determine if a customized gamma-camera can accurately localize the seeds during implantation. Monte Carlo simulations of a CZT based gamma-camera were used to assess whether images of suitable quality could be derived by detecting the 21 keV photons emitted from 74 MBq 103Pd brachytherapy seeds. A hexagonal parallel hole collimator with a hole length of 38 mm, hole diameter of 1.2 mm and 0.2 mm septa, was modeled. The design of the gamma-camera was evaluated on a realistic model of the breast and three layers of the seed distribution (55 seeds) based on a pre-implantation CT treatment plan. The Monte Carlo simulations showed that the gamma-camera was able to localize the seeds with a maximum error of 2.0 mm, using only two views and 20 s of imaging. A gamma-camera can potentially be used as an intra-procedural image guidance system for quality assurance for permanent breast seed implantation

  9. Study of a new architecture of gamma cameras with Cd/ZnTe/CdTe semiconductors

    International Nuclear Information System (INIS)

    This thesis studies new semi conductors for gammas cameras in order to improve the quality of image in nuclear medicine. The chapter 1 reminds the general principle of the imaging gamma, by describing the radiotracers, the channel of detection and the types of Anger gamma cameras acquisition. The physiological, physical and technological limits of the camera are then highlighted, to better identify the needs of future gamma cameras. The chapter 2 is dedicated to a bibliographical study. At first, semi-conductors used in imaging gamma are presented, and more particularly semi-conductors CDTE and CdZnTe, by distinguishing planar detectors and monolithic pixelated detectors. Secondly, the classic collimators of the gamma cameras, used in clinical routine for the most part of between them, are described. Their geometry is presented, as well as their characteristics, their advantages and their inconveniences. The chapter 3 is dedicated to a state of art of the simulation codes dedicated to the medical imaging and the methods of reconstruction in imaging gamma. These states of art allow to introduce the software of simulation and the methods of reconstruction used within the framework of this thesis. The chapter 4 presents the new architecture of gamma camera proposed during this work of thesis. It is structured in three parts. The first part justifies the use of semiconducting detectors CdZnTe, in particular the monolithic pixelated detectors, by bringing to light their advantages with regard to the detection modules based on scintillator. The second part presents gamma cameras to base of detectors CdZnTe (prototypes or commercial products) and their associated collimators, as well as the interest of an association of detectors CdZnTe in the classic collimators. Finally, the third part presents in detail the HiSens architecture. The chapter 5 describes both software of simulation used within the framework of this thesis to estimate the performances of the Hi

  10. Gamma camera calibration and validation for quantitative SPECT imaging with (177)Lu.

    Science.gov (United States)

    D'Arienzo, M; Cazzato, M; Cozzella, M L; Cox, M; D'Andrea, M; Fazio, A; Fenwick, A; Iaccarino, G; Johansson, L; Strigari, L; Ungania, S; De Felice, P

    2016-06-01

    Over the last years (177)Lu has received considerable attention from the clinical nuclear medicine community thanks to its wide range of applications in molecular radiotherapy, especially in peptide-receptor radionuclide therapy (PRRT). In addition to short-range beta particles, (177)Lu emits low energy gamma radiation of 113keV and 208keV that allows gamma camera quantitative imaging. Despite quantitative cancer imaging in molecular radiotherapy having been proven to be a key instrument for the assessment of therapeutic response, at present no general clinically accepted quantitative imaging protocol exists and absolute quantification studies are usually based on individual initiatives. The aim of this work was to develop and evaluate an approach to gamma camera calibration for absolute quantification in tomographic imaging with (177)Lu. We assessed the gamma camera calibration factors for a Philips IRIX and Philips AXIS gamma camera system using various reference geometries, both in air and in water. Images were corrected for the major effects that contribute to image degradation, i.e. attenuation, scatter and dead- time. We validated our method in non-reference geometry using an anthropomorphic torso phantom provided with the liver cavity uniformly filled with (177)LuCl3. Our results showed that calibration factors depend on the particular reference condition. In general, acquisitions performed with the IRIX gamma camera provided good results at 208keV, with agreement within 5% for all geometries. The use of a Jaszczak 16mL hollow sphere in water provided calibration factors capable of recovering the activity in anthropomorphic geometry within 1% for the 208keV peak, for both gamma cameras. The point source provided the poorest results, most likely because scatter and attenuation correction are not incorporated in the calibration factor. However, for both gamma cameras all geometries provided calibration factors capable of recovering the activity in

  11. A High Dose-Rate Gamma Irradiation Test of Passive Elements of Radiation- Tolerant Camera System

    International Nuclear Information System (INIS)

    In this paper, a high dose-rate gamma-ray irradiation test of passive elements, which are components of radiation-tolerant camera system, is described. In the overhaul period of the nuclear power plant, integrity of the neutron-irradiated fuel assembly is evaluated. Among the evaluation methods for the integrity of the neutron-irradiated fuel assembly during the normal operation cycle of the nuclear power plant, VT(visual test) of the four face of nuclear fuel assembly is a major concern. As the neutron-irradiated fuel assembly is a high dose-rate gamma-ray source, approximately a few kGy, radiation-hardened camera composed of vidicon tube-type image sensors is used in the VT. The VT of the four face of nuclear fuel assembly, which is a high dose-rate gamma source, is performed in the canal. The width of canal, d.., is about 1,500mm. As the distance, d2, between the fuel assembly (d3 , 224mm) and the camera system, assumed that the width of camera system is about 200mm, is short below one tenth shielding thickness of gamma-ray of water, about 660mm, a COTS CCD device can not be used directly. As the image resolution of the COTS CCD device is higher than vidicon-tube type image sensor, the VT of the four face of the nuclear fuel assembly is clearly performed, if assumed that the radiation-weakened CCD device is properly shielded from the high dose rate gamma-ray source. In this paper, it is assumed that a radiation-tolerant camera system, which are composed of COTS CCD camera, zoom lens, anti-reflection mirror, and visible window, is used in the VT of the nuclear fuel assembly. And the COTS CCD camera and zoom lens module are shielded from a high dose-rate gamma-ray source using the high-density material, lead or tungsten. The passive elements, mirror and visible window, which are placed in the optical path of CCD camera, are exposed to a high dose-rate gamma-ray source directly. So, the gamma ray irradiation characteristics of passive elements, is needed to test

  12. Theoretical considerations of a new electronically collimated gamma camera utilizing gas scintillation

    International Nuclear Information System (INIS)

    A new electronically collimated gamma camera utilizing a gas scintillation position-sensitive detector and a multiwire proportional chamber is proposed and its imaging characteristics are discussed in this paper. The scheme preserves all the advantages of an electronically collimated system (ECS) i.e. high sensitivity and simultaneous multiple views of the object over the conventional NaI gamma camera. Compared with the Ge based ECS, this scheme would have higher spatial resolution and avoid the construction difficulties of a large area Ge detector

  13. Bullet scintigraphy: can gamma camera be used for depleted uranium accident measurements?

    International Nuclear Information System (INIS)

    The aim of this study was to see could gamma cameras be used for measurement of internal contamination with depleted uranium. Radioactive waste depleted uranium, which is by-product from the production of enriched fuel for nuclear rectors and weapons now, is used for manufacture bullets, which are used in Iraq, Republic of Srpska and Yugoslavia. In this paper is measured minimum detectable activity (MDA) of gamma cameras for depleted uranium, iodine and technetium. For detection of the depleted uranium are used low energy X-rays, energy of 100 keV with 20% windows width. About 40% of gamma emissions of the depleted uranium are in these limits. Measured MDA activities 50-100 Bq for depleted uranium, iodine and technetium are about ten times more than same for WBC (5 Bq). Gamma cameras can be used for relatively measurement of depleted uranium activity, what can be used for absorbed dose estimation. Detection of low level internal contamination with depleted uranium can be done with gamma cameras. (author)

  14. Bullet scintigraphy: can gamma camera be used for depleted uranium accident measurements?

    International Nuclear Information System (INIS)

    The aim of this study was to see could gamma cameras be used for measurement of internal contamination with depleted uranium. Radioactive waste depleted uranium, which is by-product from the production of enriched fuel for nuclear rectors and weapons now, is used for manufacture bullets, which are used in Iraq, Republic of Srpska and Yugoslavia. In this paper is measured minimum detectable activity (MDA) of gamma cameras for depleted uranium, iodine and technetium. For detection of the depleted uranium are used low energy X-rays, energy of 100 keV with 20% windows width. About 40% of gamma emissions of the depleted uranium are in these limits. Measured MDA activities 50-100 Bq for depleted uranium, iodine and technetium are about then times more then same for WBC (5 Bq). Gamma cameras can be used for relatively measurement of depleted uranium activity, what can be used for absorbed dose estimation. Detection of low level internal contamination with depleted uranium can be done with gamma cameras. (authors)

  15. A Compton camera prototype for prompt gamma medical imaging

    Directory of Open Access Journals (Sweden)

    Thirolf P.G.

    2016-01-01

    Full Text Available Compton camera prototype for a position-sensitive detection of prompt γ rays from proton-induced nuclear reactions is being developed in Garching. The detector system allows to track the Comptonscattered electrons. The camera consists of a monolithic LaBr3:Ce scintillation absorber crystal, read out by a multi-anode PMT, preceded by a stacked array of 6 double-sided silicon strip detectors acting as scatterers. The LaBr3:Ce crystal has been characterized with radioactive sources. Online commissioning measurements were performed with a pulsed deuteron beam at the Garching Tandem accelerator and with a clinical proton beam at the OncoRay facility in Dresden. The determination of the interaction point of the photons in the monolithic crystal was investigated.

  16. Performance characteristics of ZLC 37 Siemens gamma camera

    International Nuclear Information System (INIS)

    The relationships between the ZLC 37 Siemens γ camera parameters (energy resolution, plane sensitivity, intrinsic uniformity, intrinsic resolution, system uniformity and system resolution) and diagnostic imaging performance was investigated. These parameters when computers when compared with internationally published data showed that the ZLC 37 Siemens γ cameras is in good operative conditions. The effect of the scattering media and WW on the spatial resolution, when the distance is kept fixed were investigated. Comparison of resolution for the media (air, water, water + radioactivity when using WW (10, 15,20%) showed that the resolution is best for air, better for water and worse for water + radioactivity up to a concentration of 8% for a 10% WW. (Author)

  17. A Compton camera prototype for prompt gamma medical imaging

    Science.gov (United States)

    Thirolf, P. G.; Aldawood, S.; Böhmer, M.; Bortfeldt, J.; Castelhano, I.; Dedes, G.; Fiedler, F.; Gernhäuser, R.; Golnik, C.; Helmbrecht, S.; Hueso-González, F.; Kolff, H. v. d.; Kormoll, T.; Lang, C.; Liprandi, S.; Lutter, R.; Marinšek, T.; Maier, L.; Pausch, G.; Petzoldt, J.; Römer, K.; Schaart, D.; Parodi, K.

    2016-05-01

    Compton camera prototype for a position-sensitive detection of prompt γ rays from proton-induced nuclear reactions is being developed in Garching. The detector system allows to track the Comptonscattered electrons. The camera consists of a monolithic LaBr3:Ce scintillation absorber crystal, read out by a multi-anode PMT, preceded by a stacked array of 6 double-sided silicon strip detectors acting as scatterers. The LaBr3:Ce crystal has been characterized with radioactive sources. Online commissioning measurements were performed with a pulsed deuteron beam at the Garching Tandem accelerator and with a clinical proton beam at the OncoRay facility in Dresden. The determination of the interaction point of the photons in the monolithic crystal was investigated.

  18. New detection modules for gamma, beta and X-ray cameras

    International Nuclear Information System (INIS)

    Full text: Ideas ASA is developing new detection modules for gamma, beta and X-ray cameras. Recent developments focus on modules using various semi-conductor materials (CZT, HgI, Si). The development includes ASIC design, detector module development, and implementation in camera heads. In this presentation we describe the characteristics of important ASICs and its properties in terms of electronic noise, and the modes for measuring signals (switched current modes, sparsified modes, self triggered modes). The ASICs are specific for detectors and applications. We describe recent developments using various semi - conductor materials. We describe important design aspects for medical applications and in life science (SPECT, beta, X-ray cameras)

  19. NUCAM3 - A Gamma Camera Using Segmented CdZnTe Detectors

    International Nuclear Information System (INIS)

    NUCAM3 is the latest generation of solid-state Pixellated gamma cameras developed at Soreq NRC. The NUCAM3 head is based on segmented pad monolithic CdZnTe detectors that currently provide a useful field of view of 18.5 cmx20.1 cm. The camera is designed for cardiac SPECT, breast scintimammography, thyroid and other small organ evaluation. We present the physical and imaging characteristics of the NUCAM3 camera and their comparison to state of the art Anger cameras. We show the advantages of CdZnTe technology, which are due to the camera pixel structure and superior energy resolution. These advantages lead to better detectability of small size cold and hot lesions in a scatter environment

  20. Dynamic Studies with a Gamma-Ray Scintillation Camera

    International Nuclear Information System (INIS)

    A commercial model γ-ray scintillation camera of the type described by Anger has been used in this laboratory since October 1962 to study dynamic physiological and pharmacological processes in vivo. The 0.6 x 20-cm Nal crystal is viewed by 19 multiplier phototubes. Light flashes generated in this plate by γ-rays are caused electronically to appear as small coruscations in the same relative positions on an oscilloscope screen. A Polaroid camera focused on this screen gradually forms a picture, the spatial densities of which represent the spatial distribution of γ-rays projected from the biological object into the collimating system. Either a 5 -mm diam. ''pinhole'' or a 771-hole multi-aperture lead collimator is used to view an area of ∼ 16-cm maximal diameter. This ingenious instrument makes true ''point-by-point'' scans electronically. The pictures have no line structure to distort perception. No mechanical difficulties are possible. The ability to view the entire area of interest continuously during a scanning seance is advantageous in reducing the dosage of radioactivity and the statistical errors. A unique feature is the opportunity provided by this camera to make pictures in fast sequence to record rapid changes in the distribution of γ-isotopes. A maximum rate of three pictures each minute has been achieved with 10-s Polaroid roll film. Motion-picture apparatus would provide even higher rates when required to record movements in extraordinarily fast processes. After I131-iodide was injected intravenously into a rat-fed Purina Labchow, a series of pictures, taken during the first 2 min of six successive 5 -min intervals, revealed rapid disappearance of the radioiodine initially distributed throughout the whole body, and concentration in the stomach region within 30 min. Most of the radioactivity remained localized there during the remaining 7 h of the experiment, at which time only a modicum had accumulated in the thyroid. Similarly, after subcutaneous

  1. An enhanced high-resolution EMCCD-based gamma camera using SiPM side detection.

    Science.gov (United States)

    Heemskerk, J W T; Korevaar, M A N; Huizenga, J; Kreuger, R; Schaart, D R; Goorden, M C; Beekman, F J

    2010-11-21

    Electron-multiplying charge-coupled devices (EMCCDs) coupled to scintillation crystals can be used for high-resolution imaging of gamma rays in scintillation counting mode. However, the detection of false events as a result of EMCCD noise deteriorates the spatial and energy resolution of these gamma cameras and creates a detrimental background in the reconstructed image. In order to improve the performance of an EMCCD-based gamma camera with a monolithic scintillation crystal, arrays of silicon photon-multipliers (SiPMs) can be mounted on the sides of the crystal to detect escaping scintillation photons, which are otherwise neglected. This will provide a priori knowledge about the correct number and energies of gamma interactions that are to be detected in each CCD frame. This information can be used as an additional detection criterion, e.g. for the rejection of otherwise falsely detected events. The method was tested using a gamma camera based on a back-illuminated EMCCD, coupled to a 3 mm thick continuous CsI:Tl crystal. Twelve SiPMs have been mounted on the sides of the CsI:Tl crystal. When the information of the SiPMs is used to select scintillation events in the EMCCD image, the background level for (99m)Tc is reduced by a factor of 2. Furthermore, the SiPMs enable detection of (125)I scintillations. A hybrid SiPM-/EMCCD-based gamma camera thus offers great potential for applications such as in vivo imaging of gamma emitters. PMID:21030743

  2. An enhanced high-resolution EMCCD-based gamma camera using SiPM side detection

    International Nuclear Information System (INIS)

    Electron-multiplying charge-coupled devices (EMCCDs) coupled to scintillation crystals can be used for high-resolution imaging of gamma rays in scintillation counting mode. However, the detection of false events as a result of EMCCD noise deteriorates the spatial and energy resolution of these gamma cameras and creates a detrimental background in the reconstructed image. In order to improve the performance of an EMCCD-based gamma camera with a monolithic scintillation crystal, arrays of silicon photon-multipliers (SiPMs) can be mounted on the sides of the crystal to detect escaping scintillation photons, which are otherwise neglected. This will provide a priori knowledge about the correct number and energies of gamma interactions that are to be detected in each CCD frame. This information can be used as an additional detection criterion, e.g. for the rejection of otherwise falsely detected events. The method was tested using a gamma camera based on a back-illuminated EMCCD, coupled to a 3 mm thick continuous CsI:Tl crystal. Twelve SiPMs have been mounted on the sides of the CsI:Tl crystal. When the information of the SiPMs is used to select scintillation events in the EMCCD image, the background level for 99mTc is reduced by a factor of 2. Furthermore, the SiPMs enable detection of 125I scintillations. A hybrid SiPM-/EMCCD-based gamma camera thus offers great potential for applications such as in vivo imaging of gamma emitters.

  3. Monte Carlo Simulation and Experimental Characterization of a Dual Head Gamma Camera

    CERN Document Server

    Rodrigues, S; Abreu, M C; Santos, N; Rato-Mendes, P; Peralta, L

    2007-01-01

    The GEANT4 Monte Carlo simulation and experimental characterization of the Siemens E.Cam Dual Head gamma camera hosted in the Particular Hospital of Algarve have been done. Imaging tests of thyroid and other phantoms have been made "in situ" and compared with the results obtained with the Monte Carlo simulation.

  4. A state-of-the-art report on the laser decontamination and gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chul Yong; Ahn, B. G.; Shim, J. B.; Won, H. J.; Lee, B. J.; Oh, W. Z

    1997-11-01

    Survey on the development status has been performed on the laser as the device of a radioactive surface decontamination and gamma camera as the device of a contamination measurement. The laser is directly applied to a radioactive contamination on the metal or the concrete surface, then the contamination is removed. Its method has the follow advantages; noncontact method, selective removal of contamination area, negligible amounts of additional waste generated. Laser cleaning process is completed at a cooling state before waste generated. Laser cleaning process is completed at a cooling state before the heat wave propagate to substrate and the contamination material is filtered by the suction device. The gamma camera show a contaminated nuclide and pattern with 2-dimension by remote measurement. The gamma camera is consist of 3 part; collimated radiation measurement part, CCTV image process part, distance measurement part. Therefore, if a radiation position and level are defined by the gamma camera and the laser device is used with remote control, it is very useful at decontamination and decommissioning of the nuclear facility. (author). 44 refs., 4 tabs., 34 figs

  5. Feasibility study of a gamma camera for monitoring nuclear materials in the PRIDE facility

    Science.gov (United States)

    Jo, Woo Jin; Kim, Hyun-Il; An, Su Jung; Lee, Chae Young; Song, Han-Kyeol; Chung, Yong Hyun; Shin, Hee-Sung; Ahn, Seong-Kyu; Park, Se-Hwan

    2014-05-01

    The Korea Atomic Energy Research Institute (KAERI) has been developing pyroprocessing technology, in which actinides are recovered together with plutonium. There is no pure plutonium stream in the process, so it has an advantage of proliferation resistance. Tracking and monitoring of nuclear materials through the pyroprocess can significantly improve the transparency of the operation and safeguards. An inactive engineering-scale integrated pyroprocess facility, which is the PyRoprocess Integrated inactive DEmonstration (PRIDE) facility, was constructed to demonstrate engineering-scale processes and the integration of each unit process. the PRIDE facility may be a good test bed to investigate the feasibility of a nuclear material monitoring system. In this study, we designed a gamma camera system for nuclear material monitoring in the PRIDE facility by using a Monte Carlo simulation, and we validated the feasibility of this system. Two scenarios, according to locations of the gamma camera, were simulated using GATE (GEANT4 Application for Tomographic Emission) version 6. A prototype gamma camera with a diverging-slat collimator was developed, and the simulated and experimented results agreed well with each other. These results indicate that a gamma camera to monitor the nuclear material in the PRIDE facility can be developed.

  6. A state-of-the-art report on the laser decontamination and gamma camera

    International Nuclear Information System (INIS)

    Survey on the development status has been performed on the laser as the device of a radioactive surface decontamination and gamma camera as the device of a contamination measurement. The laser is directly applied to a radioactive contamination on the metal or the concrete surface, then the contamination is removed. Its method has the follow advantages; noncontact method, selective removal of contamination area, negligible amounts of additional waste generated. Laser cleaning process is completed at a cooling state before waste generated. Laser cleaning process is completed at a cooling state before the heat wave propagate to substrate and the contamination material is filtered by the suction device. The gamma camera show a contaminated nuclide and pattern with 2-dimension by remote measurement. The gamma camera is consist of 3 part; collimated radiation measurement part, CCTV image process part, distance measurement part. Therefore, if a radiation position and level are defined by the gamma camera and the laser device is used with remote control, it is very useful at decontamination and decommissioning of the nuclear facility. (author). 44 refs., 4 tabs., 34 figs

  7. A study on the optimization of optical guide of gamma camera detector

    International Nuclear Information System (INIS)

    An optical guide, which is a light guide located between NaI(Tl) scintillation-crystal and array of photo-multiplier tubes (PMTs) in the gamma camera detector system, is an essential component to deliver the spatial information recorded in scintillator to the PMTs. Without the optical guide, the spatial information within the range of a single PMT could not be obtained. For the design of the optimal optical guide, it is necessary to characterize its properties, especially sensitivity and spatial resolution of detector. In this study, the thickness and the refractive index of optical guide, which affect not only on the sensitivity but also on the spatial resolution of gamma-camera detector, were investigated by using Monte Carlo simulation. A 12'x12'x3/8' NaI(Tl) and 23 PMTs with each 5' diameter were considered as a gamma-camera detector components. Interactions of optical photons in the scintillator and the optical guide were simulated using a commercial code DETECT97, and the spatial resolution, mainly interfered by the intrinsic inward distortion within the PMT, was investigated using our own ANGER program, which was developed to calculate positions of incident photons in the gamma camera. From the simulation results, it was found that an optical guide with 1.6 of refractive index and 10 mm of thickness give maximum sensitivity and minimum spatial distortion, respectively

  8. Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionine

    DEFF Research Database (Denmark)

    Madsen, Jan L.; Sjögreen-Gleisner, Katarina; Elema, Dennis Ringkjøbing;

    2014-01-01

    ]SeMet was retained within the body after 7 d. In contrast, the measured excretion in urine and faeces for the 7 d period was 8•2 (SD 1•1)% of the activity. Time–activity curves were generated for the whole body, stomach, liver, abdomen (other than the stomach and the liver), brain and femoral muscles. Gamma camera...

  9. A protocol for the calibration of gamma cameras to estimate internal contamination in emergency situations

    International Nuclear Information System (INIS)

    The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera is used for image diagnosis, it can be calibrated with anthropomorphic phantoms or point sources for the quantification of radionuclide activities in the human body. This work presents a protocol for the calibration of gamma cameras for such application. In order to evaluate the suitability of this type of equipment, a gamma camera available in a public hospital located in Rio de Janeiro was calibrated for the in vivo measurement of 131I. The calibration includes the determination of detection efficiencies and minimum detectable activities for each radionuclide. The results show that the gamma camera presents enough sensitivity to detect activity levels corresponding to effective doses below 1 mSv. The protocol is the basis to establish a network of Nuclear Medicine Centres, located in public hospitals in eight countries of Latin America (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru and Uruguay) and in Spain that could be requested to collaborate in remediation actions in the event of an accident involving incorporation of radioactive materials. This protocol is one of the most significant outputs of the IAEA-ARCAL Project (RLA/9/049-LXXVIII) aimed to the Harmonization of Internal Dosimetry Procedures. (authors)

  10. A protocol for the calibration of gamma cameras to estimate internal contamination in emergency situations

    Energy Technology Data Exchange (ETDEWEB)

    Dantas, B.M.; Lucena, E.A.; Dantas, A.L.A.; Araujo, F.; Melo, D. [Instituto de Radioprotecao e Dosimetria, CNEN, Av. Salvador Allende s/n, Rio de Janeiro (Brazil); Rebelo, A.M.O. [University Hospital, Nuclear Medicine Center, Rio de Janeiro (Brazil); Teran, M.; Paolino, A. [Facultad de Quimica, Montevideo (Uruguay); Hermida, J.C. [Hospital de Clinicas, Facultad de Medicina, Montevideo (Uruguay); Rojo, A.M. [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina); Puerta, J.A.; Morales, J. [Universidad Nacional de Colombia, Medellin (Colombia); Bejerano, G.M.L. [Centro de Proteccion e Higiene de las Radiaciones, Ciudad de la Habana (Cuba); Alfaro, M.; Ruiz, M.A. [Instituto Nacional de Investigaciones Nucleares, Ocoyoacac (Mexico); Videla, R.; Pinones, O. [Comision Chilena de Energia Nuclear, Santiago (Chile); Gonzalez, S. [Instituto Peruano de Energia Nuclear, Lima (Peru); Navarro, T. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid (Spain); Cruz-Suarez, R. [International Atomic Energy Agency, Vienna (Austria)

    2007-07-01

    The concern about accidents involving radioactive materials has led to the search of alternative methods to quickly identify and quantify radionuclides in workers and in the population. One of the options to face up an eventual demand for mass monitoring of internal contamination is the use of a nuclear medicine diagnostic equipment known as gamma camera, a device used to scan patients who have been administered specific amounts of radioactive materials for medical purposes. Although the gamma camera is used for image diagnosis, it can be calibrated with anthropomorphic phantoms or point sources for the quantification of radionuclide activities in the human body. This work presents a protocol for the calibration of gamma cameras for such application. In order to evaluate the suitability of this type of equipment, a gamma camera available in a public hospital located in Rio de Janeiro was calibrated for the in vivo measurement of {sup 131}I. The calibration includes the determination of detection efficiencies and minimum detectable activities for each radionuclide. The results show that the gamma camera presents enough sensitivity to detect activity levels corresponding to effective doses below 1 mSv. The protocol is the basis to establish a network of Nuclear Medicine Centres, located in public hospitals in eight countries of Latin America (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru and Uruguay) and in Spain that could be requested to collaborate in remediation actions in the event of an accident involving incorporation of radioactive materials. This protocol is one of the most significant outputs of the IAEA-ARCAL Project (RLA/9/049-LXXVIII) aimed to the Harmonization of Internal Dosimetry Procedures. (authors)

  11. SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

    International Nuclear Information System (INIS)

    Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an array of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images

  12. SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, M; Spiro, A [Loyola University Maryland, Baltimore, Maryland (United States); Vogel, R [Iowa Doppler Products, Iowa City, Iowa (United States); Donaldson, N; Gosselin, C [Rockhurst University, Kansas City, MO (United States)

    2015-06-15

    Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an array of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images.

  13. A digital variable persistence oscilloscope for gamma cameras

    International Nuclear Information System (INIS)

    The system briefly described is intended as a direct replacement for the analogue persistence oscilloscope, particularly in systems without a computer processor. It uses digital and video techniques to produce an image quality suitable for use in positioning patients under the camera at a low cost (total cost of materials used, Pound500). The performance is superior to the analogue oscilloscope in that the image is displayed with 16 shades of grey. It incorporates an automatic brightness control which ensures that the image does not saturate at high count density, and the saturation can be changed manually allowing areas of low counts to be examined in the presence of high counts. The digital inability to store each single event as a dot which fades exponentially with time has been solved by adding each event into the appropriate cell of a digital display matrix, and then periodically dividing the contents of each image cell by two. The cells are addressed and divided in a pseudo-random pattern so that, to the observer, the whole image appears to fade smoothly and evenly. (U.K.)

  14. Design, development, and evaluation of a direct gamma camera interface to the Macintosh II computer

    International Nuclear Information System (INIS)

    This paper presents a study to evaluate the potential of a microcomputer (Macintosh II) for direct acquisition, processing, display, and telecommunication of gamma-camera images. Use of such a computer would offer major advantages over existing systems, including reduced cost, standard user interface, image display with greater spatial resolution, use of standard output devices such as laser and film printers, and easily implemented networking. A 2-μsec, 12-bit A-to-D conversion system, hardware-image zooming system, and computer interface were designed, constructed, and interfaced to two gamma-cameras. Software was written in C and assembly language for routine processing of cardiac and other images. Data could be directly acquired from gamma-cameras at rates exceeding 200,000 points per second, with spatial resolution exceeding intrinsic camera resolution (512 x 512 pixel images). Clinical variables such as cardiac ejection fraction (first pass of gated) could be rapidly assessed. With ISDN, images could be remotely transmitted at rates exceeding 50,000 baud

  15. Simulation of the functioning of a gamma camera using Monte Carlo method; Simulacion del funcionamiento de una camara gamma mediante metodo Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Oramas Polo, I.

    2014-07-01

    This paper presents the simulation of the gamma camera Park Isocam II by Monte Carlo code SIMIND. This simulation allows detailed assessment of the functioning of the gamma camera. The parameters evaluated by means of the simulation are: the intrinsic uniformity with different window amplitudes, the system uniformity, the extrinsic spatial resolution, the maximum rate of counts, the intrinsic sensitivity, the system sensitivity, the energy resolution and the pixel size. The results of the simulation are compared and evaluated against the specifications of the manufacturer of the gamma camera and taking into account the National Protocol for Quality Control of Nuclear Medicine Instruments of the Cuban Medical Equipment Control Center. The simulation reported here demonstrates the validity of the SIMIND Monte Carlo code to evaluate the performance of the gamma camera Park Isocam II and as result a computational model of the camera has been obtained. (Author)

  16. Design of a Compton camera for 3D prompt-{gamma} imaging during ion beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Roellinghoff, F., E-mail: roelling@ipnl.in2p3.fr [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Richard, M.-H., E-mail: mrichard@ipnl.in2p3.fr [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Chevallier, M.; Constanzo, J.; Dauvergne, D. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Freud, N. [INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Henriquet, P.; Le Foulher, F. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Letang, J.M. [INSA-Lyon Laboratory of Nondestructive Testing using Ionizing Radiation (CNDRI), F-69621 Villeurbanne Cedex (France); Montarou, G. [LPC, CNRS/IN2P3, Clermont-F. University (France); Ray, C.; Testa, E.; Testa, M. [Universite de Lyon, F-69622 Lyon (France); Universite Lyon 1 and CNRS/IN2P3, UMR 5822, IPNL, F-69622 Villeurbanne (France); Walenta, A.H. [Uni-Siegen, FB Physik, Emmy-Noether Campus, D-57068 Siegen (Germany)

    2011-08-21

    We investigate, by means of Geant4 simulations, a real-time method to control the position of the Bragg peak during ion therapy, based on a Compton camera in combination with a beam tagging device (hodoscope) in order to detect the prompt gamma emitted during nuclear fragmentation. The proposed set-up consists of a stack of 2 mm thick silicon strip detectors and a LYSO absorber detector. The {gamma} emission points are reconstructed analytically by intersecting the ion trajectories given by the beam hodoscope and the Compton cones given by the camera. The camera response to a polychromatic point source in air is analyzed with regard to both spatial resolution and detection efficiency. Various geometrical configurations of the camera have been tested. In the proposed configuration, for a typical polychromatic photon point source, the spatial resolution of the camera is about 8.3 mm FWHM and the detection efficiency 2.5x10{sup -4} (reconstructable photons/emitted photons in 4{pi}). Finally, the clinical applicability of our system is considered and possible starting points for further developments of a prototype are discussed.

  17. Analysis of dark current images of a CMOS camera during gamma irradiation

    International Nuclear Information System (INIS)

    Highlights: • Radiation tolerance of a fast framing CMOS camera EDICAM examined. • We estimate the expected gamma dose and spectrum of EDICAM with MCNP. • We irradiate EDICAM by 23.5 Gy in 70 min in a fission rector. • Dose rate normalised average brightness of frames grows linearly with the dose. • Dose normalised average brightness of frames follows the dose rate time evolution. -- Abstract: We report on the behaviour of the dark current images of the Event Detection Intelligent Camera (EDICAM) when placed into an irradiation field of gamma rays. EDICAM is an intelligent fast framing CMOS camera operating in the visible spectral range, which is designed for the video diagnostic system of the Wendelstein 7-X (W7-X) stellarator. Monte Carlo calculations were carried out in order to estimate the expected gamma spectrum and dose for an entire year of operation in W7-X. EDICAM was irradiated in a pure gamma field in the Training Reactor of BME with a dose of approximately 23.5 Gy in 1.16 h. During the irradiation, numerous frame series were taken with the camera with exposure times 20 μs, 50 μs, 100 μs, 1 ms, 10 ms, 100 ms. EDICAM withstood the irradiation, but suffered some dynamic range degradation. The behaviour of the dark current images during irradiation is described in detail. We found that the average brightness of dark current images depends on the total ionising dose that the camera is exposed to and the dose rate as well as on the applied exposure times

  18. Use of gamma camera for measurement of the internal contamination with depleted uranium

    International Nuclear Information System (INIS)

    Depleted uranium from radioactive wastes is used for manufacturing bullets used in Iraq, Republic of Serbia and Yugoslavia. These bullets are extremely dense and capable of penetrating heavily armored vehicles. Their medical importance lies in the fact that the bullets contain seventy percent depleted uranium which creates aerosolized particles less than five microns in diameter, small enough to be inhaled, after spontaneous bullet burn at impact. Nuclear medicine scientists must be aware of this and be prepared to measure internal contamination of persons exposed to this radioactive material. Whole body counters (WBC) represent appropriate equipment for this purpose but their availability in developing countries is not sufficient. Gamma camera is an alternative. The minimum detectable activity (MDA) of depleted uranium, iodine and technetium for gamma cameras was measured in this paper. Low energy X-ray 100 KeV with 20% windows are used for the depleted uranium detection. About 40% gamma emissions from depleted uranium fall within these limits. The activities measured (50-100 Bq) are about ten times higher then on WBC (5 Bq). This does not limit the use of gamma cameras for measurement of lung or whole body internal contamination with depleted uranium. (author)

  19. Development of a panorama coded-aperture gamma camera for radiation detection

    International Nuclear Information System (INIS)

    For radiation detection, the imaging system should have a large field of view (FOV) and high detection efficiency because it has to be used in a radiation environment where the quantity and direction of radioactive sources are unknown. A panorama coded-aperture gamma camera optimized for use in complex nuclear environment has been developed and evaluated with an angular resolution of 3.5°. Typical gamma cameras have the limited field of view ranging from 10° to 60° in both horizontal and vertical direction. The system presented in this paper extends the field of view to 360° in the horizontal direction and 60° in the vertical direction. The partial encoding of coded aperture imaging is mitigated by convolving the data of diverse adjacent modules with a partial transmission function. The experimental feasibility of measuring multiple sources in the 360° horizontal field of view was demonstrated with a panoramic image. The results showed that the system could clearly identify the direction of multiple radiation sources in an unknown extended radiation environment. The system can help to simplify the clean up and decommissioning of nuclear sites. - Highlights: • Development of a coded-aperture gamma camera. • Panoramic gamma ray imaging in real time. • Mitigate the partial encoding of coded aperture imaging (CAI). • Experimental validation

  20. Computer simulation of the light collection process in scintillation gamma-ray cameras

    International Nuclear Information System (INIS)

    A computer simulation program based on the Monte Carlo method is presented. The physical model takes into account the main phenomena which occur from the interaction of a gamma quantum with the scintillating crystal to the primary electron emission by the photocathode of photomultiplier tubes closely coupled to the large scintillator plate of the camera head. Computed and experimental results of the mean values as well as the statistical characteristics of signals delivered by the photomultiplier tubes are found to be in good agreement for various camera head configurations. The usefulness of this computer program is shown

  1. Real-time Data Acquisition and Maximum-Likelihood Estimation for Gamma Cameras

    OpenAIRE

    Furenlid, L R; Hesterman, J.Y.; Barrett, H. H.

    2005-01-01

    We have developed modular gamma-ray cameras for biomedical imaging that acquire data with a raw list-mode acquisition architecture. All observations associated with a gamma-ray event, such as photomultiplier (PMT) signals and time, are assembled into an event packet and added to an ordered list of event entries that comprise the acquired data. In this work we present the design of the data-acquisition system, and discuss algorithms for a specialized computing engine to reside in the data path...

  2. Technical features and roles of Cobalt-57 flood sources for daily quality control of gamma cameras

    International Nuclear Information System (INIS)

    Quality control (QC) detects changes in the performance of gamma cameras that could adversely affect interpretations of clinical studies. We used plate and sheet 57Co flood sources to measure extrinsic uniformity during daily QC. Each source, when placed on the top of a collimated detector, allowed the acquisition of uniform images from both detectors, thus reducing the amount of time needed to perform daily QC. No serious problems with the gamma camera system were revealed by visual checks, and changes in detector sensitivity were rapidly determined by observing daily variations in the measured values of extrinsic uniformity. Furthermore, 57Co flood sources confer advantages in that they shorten the time required for preparation of flood sources and reduce the consequent exposure of medical staff to radiation. (author)

  3. A portable device for small animal SPECT imaging in clinical gamma-cameras

    International Nuclear Information System (INIS)

    Molecular imaging is reshaping clinical practice in the last decades, providing practitioners with non-invasive ways to obtain functional in-vivo information on a diversity of relevant biological processes. The use of molecular imaging techniques in preclinical research is equally beneficial, but spreads more slowly due to the difficulties to justify a costly investment dedicated only to animal scanning. An alternative for lowering the costs is to repurpose parts of old clinical scanners to build new preclinical ones. Following this trend, we have designed, built, and characterized the performance of a portable system that can be attached to a clinical gamma-camera to make a preclinical single photon emission computed tomography scanner. Our system offers an image quality comparable to commercial systems at a fraction of their cost, and can be used with any existing gamma-camera with just an adaptation of the reconstruction software

  4. A photon counting CdTe gamma- and X-ray camera

    International Nuclear Information System (INIS)

    A photon counting CdTe imaging camera suitable for gamma- and X-ray detection has been developed and tested. The current full active imaging area of the gamma/X-ray camera covers 44x44 mm2. The camera is built of eight individual detector hybrids each consisting of a pixelated CdTe detector with dimensions of 22x11 mm2 and solder bump-bonded to a photon counting custom-designed application specific integrated circuit (ASIC). The ASICs are realized in a mixed signal, 0.35 μm 4 metal 2 poly CMOS process. The effective pixel size (image pixel pitch) is 0.5 mm. To enable higher count rate imaging and to achieve better position resolution in X-ray CT scanning each pixel is divided both on the CdTe detector and on the ASIC into two sub-pixels with dimensions 0.25x0.5 mm2. Every pixel circuit has two preamps each connected to one sub-pixel and feeding signal to a separate comparator. The digital pulses of the two distinct comparators are recorded by one common 8-bit counter. The amplifier offsets can be adjusted individually with 3-bit accuracy to compensate for process mismatch. A similar 3-bit gain tuning common to the two amplifiers in one pixel circuit is also implemented. A globally tuneable threshold voltage generated externally with high accuracy is used for energy discrimination. The camera can be operated both in the real time imaging mode with a maximum speed of 100 frames/s and in the accumulation mode with user adjustable counting time. Experimental data collected from a fully operational eight hybrid gamma/X-ray camera is presented and compared to simulated data. The camera exhibits excellent sensitivity and a dynamic range of 1:14,000,000. A sharp line spread function indicates the spatial resolution to be limited only by the pixel size (0.5 mm). A single pixel energy resolution of FWHM 4.7 keV at 122 keV (3.9%) was determined from measured 57Co spectra. The peak width of the spectrum combined from all pixels was somewhat larger due to calibration

  5. A novel camera type for very high energy gamma-astronomy

    International Nuclear Information System (INIS)

    Full text: Results of the FACT project are presented. The significant progress of semiconductor photodetectors in the past years, resulting in the development of Geiger-mode avalanche photodiodes (G-APD), allows to realise a novel camera type for imaging air Cherenkov telescopes. The project 'First G-APD Camera Test' (FACT), initiated by ETH Zuerich, uses G-APDs to measure Cherenkov light from airshowers originating from very high energetic gamma-rays. G-APDs offer enhanced properties compared to standard photomultipliers (e.g. compactness, homogeneous angular acceptance and tolerance of bright light). The camera is foreseen for the DWARF telescope which will be dedicated to the long-term monitoring of bright blazars. (author)

  6. From whole-body counting to imaging: The computer aided collimation gamma camera project (CACAO)

    International Nuclear Information System (INIS)

    Whole-body counting is the method of choice for in vivo detection of contamination. To extend this well established method, the possible advantages of imaging radiocontaminants are examined. The use of the CACAO project is then studied. A comparison of simulated reconstructed images obtained by the CACAO project and by a conventional gamma camera used in nuclear medicine follows. Imaging a radionuclide contaminant with a geometrical sensitivity of 10-2 seems possible in the near future. (author)

  7. Determination of bone mineral content in the heel bone using a gamma camera

    International Nuclear Information System (INIS)

    An easy to use and low cost technique for determination of the bone mineral content in the heel bone using an unmodified gamma camera is described. The method uses two small flood phantoms with 125I and 99Tcm, respectively. The precision, when measured on 12 healthy volunteers, was 2.1% and a long-term reproducibility in vitro of 1.8% was obtained on phantoms. (author)

  8. Feasibility study of a lens-coupled charge-coupled device gamma camera

    International Nuclear Information System (INIS)

    A charge-coupled device (CCD) is generally used in a digital camera as a light-collecting device such as a photomultiplier tube (PMT). Because of its low sensitivity and very high dark current, CCD have not been popularly used for gamma imaging systems. However, a recent CCD technological breakthrough has improved CCD sensitivity, and the use of a Peltier cooling system can significantly minimize the dark current. In this study, we investigated the feasibility of a prototype CCD gamma camera consisting of a CsI scintillator, optical lenses, and a CCD module. Despite electron-multiplying (EM) CCDs having higher performance, in this study, we built a cost-effective system consisted of low-cost components compared to EMCCDs. Our prototype detector consists of a CsI scintillator, two optical lenses, and a conventional Peltier-cooled CCD. The performance of this detector was evaluated by acquiring the sensitivity, resolution, and the modulation transfer function (MTF). The sensitivity of the prototype detector showed excellent linearity. With a 1 mm-diameter pinhole collimator, the full width at half-maximum (FWHM) of a 1.1 mm Tc-99m line source image was 2.85 mm. These results show that the developed prototype camera is feasible for small animal gamma imaging.

  9. Calculation of renal depth by conjugate-view method using dual-head gamma camera

    International Nuclear Information System (INIS)

    In this study, we developed a new method for the determination of renal depth with anterior and posterior renal scintigrams in a dual-head gamma camera, considering the attenuation factor e-μx of the conjugate-view method. We developed abdomen and kidney phantoms to perform experiments using Technetium-99m dimercaptosuccinic acid (99mTc-DMSA). The phantom images were obtained by dual-head gamma camera equipped with low-energy, high-resolution, parallel-hole collimators (ICONf, Siemens). The equation was derived from the linear integration of emission γ-ray considering attenuation from the posterior abdomen to the anterior abdomen phantom surface. The program for measurement was developed by Microsoft Visual C++ 6.0. Renal depths of the phantoms were derived from the derived equations and compared with the exact geometrical values. Differences between the measured and the calculated values were the range of 0.1 to 0.7 cm (0.029± 0.15 cm, mean ±S. D.). The present study showed that the use of the derived equations for renal depth measurement, combined with quantitative planar imaging using duel-head gamma camera, could provide more accurate results for individual variation than the conventional method

  10. Preliminary experience with small animal SPECT imaging on clinical gamma cameras.

    Science.gov (United States)

    Aguiar, P; Silva-Rodríguez, J; Herranz, M; Ruibal, A

    2014-01-01

    The traditional lack of techniques suitable for in vivo imaging has induced a great interest in molecular imaging for preclinical research. Nevertheless, its use spreads slowly due to the difficulties in justifying the high cost of the current dedicated preclinical scanners. An alternative for lowering the costs is to repurpose old clinical gamma cameras to be used for preclinical imaging. In this paper we assess the performance of a portable device, that is, working coupled to a single-head clinical gamma camera, and we present our preliminary experience in several small animal applications. Our findings, based on phantom experiments and animal studies, provided an image quality, in terms of contrast-noise trade-off, comparable to dedicated preclinical pinhole-based scanners. We feel that our portable device offers an opportunity for recycling the widespread availability of clinical gamma cameras in nuclear medicine departments to be used in small animal SPECT imaging and we hope that it can contribute to spreading the use of preclinical imaging within institutions on tight budgets. PMID:24963478

  11. Modeling High Energy (I-131) Pinhole Collimator for Small Animal Gamma Camera by Monte Carlo Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Young Jun; Kim, Kyeong Min; Kim, Jin Su; Park, Ji Ae; Lee, Young Sub; Yoo, A-ram; Kim, Jong Guk [Korea Institute of Radiologic and Medical Sciences, Seoul (Korea, Republic of); Lee, Hak Jae; Lee, Ki Sung [Korea University, Seoul (Korea, Republic of)

    2011-05-15

    In medical nuclear imaging, I-131 takes important role in not only the diagnostic image, but also the quantitative evaluation in nuclear medicine therapy. However, due to the relatively high energy peak of I-131[364 keV (82 %), 326 keV (0.27 %), 503 keV (0.36 %), 637 keV (7.18 %), 643 keV (0.22 %), 723 keV (1.77 %)], it is difficult to construct high resolution, high sensitivity preclinical gamma camera. Especially, 637 keV, 723 keV energy, penetration and scattering occur in relatively high possibility. In this manner, penetration and scattering of high energy gamma ray in collimator degrades image quality fatally. According to the characteristics, it is essential to design collimator which can minimize the degrading factor, and preserve the gamma ray for imaging at the same time. In this study, we designed and simulated the structure of pinhole collimator for a small animal high energy gamma camera by Monte Carlo simulation (GATE 6.0). In this model, the diameter, channel length of pinhole and the thickness of collimator are the main issue for determining the system sensitivity. Thus, in this study, we observed the difference in the number of photons on the scintillator which pass through the collimator that determined by those three factors

  12. Modeling of a slanted-hole collimator in a compact endo-cavity gamma camera.

    Science.gov (United States)

    Kamuda, Mark; Cui, Yonggang; Lall, Terry; Ionson, Jim; Camarda, Giuseppe S.; Hossain, Anwar; Yang, Ge; Roy, Utpal N.; James, Ralph B.

    2013-09-01

    Having the ability to take an accurate 3D image of a tumor greatly helps doctors diagnose it and then create a treatment plan for a patient. One way to accomplish molecular imaging is to inject a radioactive tracer into a patient and then measure the gamma rays emitted from regions with high-uptake of the tracer, viz., the cancerous tissues. In large, expensive PET- or SPECT-imaging systems, the 3D imaging easily is accomplished by rotating the gamma-ray detectors and then employing software to reconstruct the 3D images from the multiple 2D projections at different angles of view. However, this method is impractical in a very compact imaging system due to anatomical considerations, e.g., the transrectal gamma camera under development at Brookhaven National Laboratory (BNL) for detection of intra-prostatic tumors. The camera uses pixilated cadmium zinc telluride (CdZnTe or CZT) detectors with matched parallel-hole collimator. Our research investigated the possibility of using a collimator with slanted holes to create 3D pictures of a radioactive source. The underlying concept is to take 2D projection images at different angles of view by adjusting the slant angle of the collimator, then using the 2D projection images to reconstruct the 3D image. To do this, we first simulated the response of a pixilated CZT detector to radiation sources placed in the field of view of the camera. Then, we formulated an algorithm to use the simulation results as prior knowledge and estimate the distribution of a shaped source from its 2D projection images. From the results of the simulation, we measured the spatial resolution of the camera as ~7-mm at a depth of 13.85-mm when using a detector with 2.46-mm pixel pitch and a collimator with 60° slant angle.

  13. Evaluation of different physical parameters that affect the clinical image quality for gamma camera by using different radionuclides

    International Nuclear Information System (INIS)

    Some scintillation camera manufactures adhere to standard code of performance specification established by National Electric Manufactures Association (NEMA). Items such as differential and integral uniformity, spatial resolution energy resolution, etc. are all calculated with reproducible methodology that allows the user reliable technique for creation of these standards to avoid any lack of clinical service that may violate the ethics of patient care. Because Tc-99m is the most frequently used radionuclide in nuclear medicine, many clinics perform the daily uniformity and weekly resolution checks using this radionuclide. But when other commonly used radionuclide such as Tl-201,Ga-67 and I-131 are used, no standardized quality control is performed. So in these study we perform to evaluate the response of ADAC (digital) gamma camera and SELO (analogue) gamma camera to four radionuclide (Tl-201,Ga-67, I-131, and Tc- 99m) flood image acquired using different non-uniformity correction tables. In the planer study uniformity and resolution images were obtained using ADAC and SELO cameras, linearity was obtained only by ADAC camera, while in the SPECT study uniformity and contrast images were obtained using ADAC camera only. The response for using different non-uniformity correction tables acquired using different isotopes was different from gamma camera model to another. We can conclude that the most of the gamma camera quality control parameters (uniformity, resolution and contrast) are influenced by variation in the correction tables, while other parameters not affected by this variation like linearity. (author)

  14. Evaluation of different physical parameters that affect the clinical image quality for gamma camera by using different radionuclides

    International Nuclear Information System (INIS)

    Some scintillation camera manufactures adhere to standard code of performance specification established by National Electric Manufactures Association (NEMA). Items such as differential and integral uniformity, spatial resolution energy resolution, etc. are all calculated with reproducible methodology that allows the user reliable technique for creation of these standards to avoid any lack of clinical service that may violate the ethics of patient care. Because 99mTc is the most frequently used radionuclide in nuclear medicine, many clinics perform the daily uniformity and weekly resolution checks using this radionuclide. But when other commonly used radionuclide such as Tl-201,Ga-67 and I-131 are used, no standardized quality control is performed. So in these study we perform to evaluate the response of ADAC(digital) gamma camera and SELO(analogue) gamma camera to four radionuclide (Tl-201,Ga-67, I-131, and 99mTc) flood image acquired using different non-uniformity correction tables. In the planer study uniformity and resolution images were obtained using ADAC and SELO cameras, linearity was obtained only by ADAC camera, while in the SPECT study uniformity and contrast images were obtained using ADAC camera only. The response for using different non-uniformity correction tables acquired using different isotopes was different from gamma camera model to another. We can conclude that the most of the gamma camera quality control parameters (uniformity, resolution and contrast) are influenced by variation in the correction tables, while other parameters not affected by this variation like linearity. (author)

  15. Detection of mixed-range proton pencil beams with a prompt gamma slit camera

    Science.gov (United States)

    Priegnitz, M.; Helmbrecht, S.; Janssens, G.; Perali, I.; Smeets, J.; Vander Stappen, F.; Sterpin, E.; Fiedler, F.

    2016-01-01

    With increasing availability of proton and particle therapy centers for tumor treatment, the need for in vivo range verification methods comes more into the focus. Imaging of prompt gamma rays emitted during the treatment is one of the possibilities currently under investigation. A knife-edge shaped slit camera was recently proposed for this task and measurements proved the feasibility of range deviation detection in homogeneous and inhomogeneous targets. In the present paper, we concentrate on laterally inhomogeneous materials, which lead to range mixing situations when crossed by one pencil beam: different sections of the beam have different ranges. We chose exemplative cases from clinical irradiation and assembled idealized tissue equivalent targets. One-dimensional emission profiles were obtained by measuring the prompt gamma emission with the slit camera. It could be shown that the resulting range deviations can be detected by evaluation of the measured data with a previously developed range deviation detection algorithm. The retrieved value, however, strongly depends on the target composition, and is not necessarily in direct relation to the ranges of both parts of the beam. By combining the range deviation detection with an analysis of the slope of the distal edge of the measured prompt gamma profile, the origin of the detected range deviation, i.e. the mixed range of the beam, is also identified. It could be demonstrated that range mixed prompt gamma profiles exhibit less steep distal slopes than profiles from beams traversing laterally homogeneous material. For future application of the slit camera to patient irradiation with double scattered proton beams, situations similar to the range mixing cases are present and results could possibly apply.

  16. Development of a pixelated GSO gamma camera system with tungsten parallel hole collimator for single photon imaging

    International Nuclear Information System (INIS)

    Purpose: In small animal imaging using a single photon emitting radionuclide, a high resolution gamma camera is required. Recently, position sensitive photomultiplier tubes (PSPMTs) with high quantum efficiency have been developed. By combining these with nonhygroscopic scintillators with a relatively low light output, a high resolution gamma camera can become useful for low energy gamma photons. Therefore, the authors developed a gamma camera by combining a pixelated Ce-doped Gd2SiO5 (GSO) block with a high quantum efficiency PSPMT. Methods: GSO was selected for the scintillator, because it is not hygroscopic and does not contain any natural radioactivity. An array of 1.9 mm x 1.9 mm x 7 mm individual GSO crystal elements was constructed. These GSOs were combined with a 0.1-mm thick reflector to form a 22 x 22 matrix and optically coupled to a high quantum efficiency PSPMT (H8500C-100 MOD8). The GSO gamma camera was encased in a tungsten gamma-ray shield with tungsten pixelated parallel hole collimator, and the basic performance was measured for Co-57 gamma photons (122 keV). Results: In a two-dimensional position histogram, all pixels were clearly resolved. The energy resolution was ∼15% FWHM. With the 20-mm thick tungsten pixelated collimator, the spatial resolution was 4.4-mm FWHM 40 mm from the collimator surface, and the sensitivity was ∼0.05%. Phantom and small animal images were successfully obtained with our developed gamma camera. Conclusions: These results confirmed that the developed pixelated GSO gamma camera has potential as an effective instrument for low energy gamma photon imaging.

  17. Heart imaging by cadmium telluride gamma cameraEuropean Program ``BIOMED'' consortium

    Science.gov (United States)

    Scheiber, Ch.; Eclancher, B.; Chambron, J.; Prat, V.; Kazandjan, A.; Jahnke, A.; Matz, R.; Thomas, S.; Warren, S.; Hage-Hali, M.; Regal, R.; Siffert, P.; Karman, M.

    1999-06-01

    Cadmium telluride semiconductor detectors (CdTe) operating at room temperature are attractive for medical imaging because of their good energy resolution providing excellent spatial and contrast resolution. The compactness of the detection system allows the building of small light camera heads which can be used for bedside imaging. A mobile pixellated gamma camera based on 2304 CdTe (pixel size: 3×3 mm, field of view: 15 cm×15 cm) has been designed for cardiac imaging. A dedicated 16-channel integrated circuit has also been designed. The acquisition hardware is fully programmable (DSP card, personal computer-based system). Analytical calculations have shown that a commercial parrallel hole collimator will fit the efficiency/resolution requirements for cardiac applications. Monte-Carlo simulations predict that the Moire effect can be reduced by a 15° tilt of the collimator with respect to the detector grid. A 16×16 CdTe module has been built for the preliminary physical tests. The energy resolution was 6.16±0.6 keV (mean ± standard deviation, n=30). Uniformity was ±10%, improving to ±1% when using a correction table. Test objects (emission data: letters 1.8 mm in width) and cold rods in scatter medium have been acquired. The CdTe images have been compared to those acquired with a conventionnal gamma camera.

  18. Heart imaging by cadmium telluride gamma camera European Program 'BIOMED' consortium

    International Nuclear Information System (INIS)

    Cadmium telluride semiconductor detectors (CdTe) operating at room temperature are attractive for medical imaging because of their good energy resolution providing excellent spatial and contrast resolution. The compactness of the detection system allows the building of small light camera heads which can be used for bedside imaging. A mobile pixellated gamma camera based on 2304 CdTe (pixel size: 3x3 mm, field of view: 15 cmx15 cm) has been designed for cardiac imaging. A dedicated 16-channel integrated circuit has also been designed. The acquisition hardware is fully programmable (DSP card, personal computer-based system). Analytical calculations have shown that a commercial parallel hole collimator will fit the efficiency/resolution requirements for cardiac applications. Monte-Carlo simulations predict that the Moire effect can be reduced by a 15 deg. tilt of the collimator with respect to the detector grid. A 16x16 CdTe module has been built for the preliminary physical tests. The energy resolution was 6.16±0.6 keV (mean ± standard deviation, n=30). Uniformity was ±10%, improving to ±1% when using a correction table. Test objects (emission data: letters 1.8 mm in width) and cold rods in scatter medium have been acquired. The CdTe images have been compared to those acquired with a conventionnal gamma camera

  19. Realization and study of spectral properties of the ISGRI gamma-ray camera; Mise en oeuvre et etude des proprietes spectrales de la gamma-camera ISGRI

    Energy Technology Data Exchange (ETDEWEB)

    Limousin, O

    2001-11-01

    This work evaluates spectroscopic and physical properties of CdTe detectors in view of assembling a large number on a new generation spectro-imager for space gamma-ray astronomy. Study, optimization, realization and calibration of modular detection units of the ISGRI camera are described. After a description of the experimental context of the INTEGRAL program and a review of the physical processes involved in gamma-ray photon detectors, we present an analysis of the properties of CdTe detectors attempting to be so exhaustive as possible. We propose the base point of a global model, which relates charge transport properties, spectral response and possible instabilities in the detectors. We propose a new formulation of the Hecht relation that describes charge loss as a function of the detector charge transport properties. We discuss at length the method of charge loss correction and its consequences on the associated integrated electronics definition. Finally, we illustrate our instrument capabilities using as an example the observation of titanium 44 lines in historical supernovae. (author)

  20. On-Line High Dose-Rate Gamma Ray Irradiation Test of the CCD/CMOS Cameras

    International Nuclear Information System (INIS)

    In this paper, test results of gamma ray irradiation to CCD/CMOS cameras are described. From the CAMS (containment atmospheric monitoring system) data of Fukushima Dai-ichi nuclear power plant station, we found out that the gamma ray dose-rate when the hydrogen explosion occurred in nuclear reactors 1∼3 is about 160 Gy/h. If assumed that the emergency response robot for the management of severe accident of the nuclear power plant has been sent into the reactor area to grasp the inside situation of reactor building and to take precautionary measures against releasing radioactive materials, the CCD/CMOS cameras, which are loaded with the robot, serve as eye of the emergency response robot. In the case of the Japanese Quince robot system, which was sent to carry out investigating the unit 2 reactor building refueling floor situation, 7 CCD/CMOS cameras are used. 2 CCD cameras of Quince robot are used for the forward and backward monitoring of the surroundings during navigation. And 2 CCD (or CMOS) cameras are used for monitoring the status of front-end and back-end motion mechanics such as flippers and crawlers. A CCD camera with wide field of view optics is used for monitoring the status of the communication (VDSL) cable reel. And another 2 CCD cameras are assigned for reading the indication value of the radiation dosimeter and the instrument. In the preceding assumptions, a major problem which arises when dealing with CCD/CMOS cameras in the severe accident situations of the nuclear power plant is the presence of high dose-rate gamma irradiation fields. In the case of the DBA (design basis accident) situations of the nuclear power plant, in order to use a CCD/CMOS camera as an ad-hoc monitoring unit in the vicinity of high radioactivity structures and components of the nuclear reactor area, a robust survivability of this camera in such intense gamma-radiation fields therefore should be verified. The CCD/CMOS cameras of various types were gamma irradiated at a dose

  1. Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras

    International Nuclear Information System (INIS)

    A stereotactic, normal perfusion database is imperative for optimal clinical brain single-photon emission tomography (SPET). However, interdepartmental use of normal data necessitates accurate transferability of these data sets. The aim of this study was to investigate transfer of three normal perfusion databases obtained in the same large population of healthy volunteers who underwent sequential scanning using multihead gamma cameras with different resolution. Eighty-nine healthy adults (46 females, 43 males; aged 20-81 years) were thoroughly screened by history, biochemistry, physical and full neurological examination, neuropsychological testing and magnetic resonance imaging. After injection of 925 MBq technetium-99m labelled ethyl cysteinate dimer (ECD) under standard conditions, 101 scans were acquired from all subjects (12 repeat studies) on a triple-head Toshiba GCA-9300A (measured average FWHM 8.1 mm). Ninety-one sequential scans were performed on a dual-head Elscint Helix camera (FWHM 9.6 mm) and 22 subjects also underwent imaging on a triple-head Prism 3000 (FWHM 9.6 mm). Images were transferred to the same processing platform and reconstructed by filtered back-projection with the same Butterworth filter (order 8, cut-off 0.9 cycles/cm) and uniform Sorensen attenuation correction (μ=0.09). After automated rigid intrasubject registration, all subjects were automatically reoriented to a stereotactic template by a nine-parameter affine transformation. The databases were analysed using 35 predefined volumes of interest (VOIs) with normalisation on total VOI counts. For comparison, the high-resolution data were smoothed with a 3D Gaussian kernel to achieve more similar spatial resolution. Hoffman phantom measurements were conducted on all cameras. Partial volume effects after smoothing varied between -6.5% and 10%, depending on VOI size. Between-camera reproducibility was 2.5% and 2.7% for the Toshiba camera versus the Helix and the Prism database

  2. New observations of TeV gamma-rays from the Crab Nebula using the Whipple Observatory high resolution camera

    International Nuclear Information System (INIS)

    The Whipple Observatory High Resolution Camera has been used to observe the Crab Nebula in TeV gamma-rays. Gamma-rays are selected from the data on the basis of their predicted image properties. Following a preliminary analysis we report a detection at the 15.0 sigma level. (orig.)

  3. A pixellated gamma-camera based on CdTe detectors clinical interests and performances

    CERN Document Server

    Chambron, J; Eclancher, B; Scheiber, C; Siffert, P; Hage-Ali, M; Regal, R; Kazandjian, A; Prat, V; Thomas, S; Warren, S; Matz, R; Jahnke, A; Karman, M; Pszota, A; Németh, L

    2000-01-01

    A mobile gamma camera dedicated to nuclear cardiology, based on a 15 cmx15 cm detection matrix of 2304 CdTe detector elements, 2.83 mmx2.83 mmx2 mm, has been developed with a European Community support to academic and industrial research centres. The intrinsic properties of the semiconductor crystals - low-ionisation energy, high-energy resolution, high attenuation coefficient - are potentially attractive to improve the gamma-camera performances. But their use as gamma detectors for medical imaging at high resolution requires production of high-grade materials and large quantities of sophisticated read-out electronics. The decision was taken to use CdTe rather than CdZnTe, because the manufacturer (Eurorad, France) has a large experience for producing high-grade materials, with a good homogeneity and stability and whose transport properties, characterised by the mobility-lifetime product, are at least 5 times greater than that of CdZnTe. The detector matrix is divided in 9 square units, each unit is composed ...

  4. Design study of a Compton camera for prompts-gamma imaging during ion beam therapy

    International Nuclear Information System (INIS)

    Ion beam therapy is an innovative radiotherapy technique using mainly carbon ion and proton irradiations. Its aim is to improve the current treatment modalities. Because of the sharpness of the dose distributions, a control of the dose if possible in real time is highly desirable. A possibility is to detect the prompt gamma rays emitted subsequently to the nuclear fragmentations occurring during the treatment of the patient. In a first time two different Compton cameras (double and single scattering) have been optimised by means of Monte Carlo simulations. The response of the camera to a photon point source with a realistic energy spectrum was studied. Then, the response of the camera to the irradiation of a water phantom by a proton beam was simulated. It was first compared with measurement performed with small-size detectors. Then, using the previous measurements, we evaluated the counting rates expected in clinical conditions. In the current set-up of the camera, these counting rates are pretty high. Pile up and random coincidences will be problematic. Finally we demonstrate that the detection system is capable to detect a longitudinal shift in the Bragg peak of ± 5 mm, even with the current reconstruction algorithm. (author)

  5. Gamma-ray spectral imaging using a single-shutter radiation camera

    International Nuclear Information System (INIS)

    As part of a program to develop mobile robots for reactor environments, we are developing a radiation-imaging camera capable of operating in medium-intensity (<2R/h), medium-energy (<8 MeV) gamma-ray fields. A systematic study of available detectors indicated the advisiability of a high-Z scintillator. The raster-scanning camera uses a lead-shielded bismuth germanate (BGO) scintillator (1.25 cmx1.25 cm right-circular cylinder) coupled to a photomultiplier tube (PMT) operated in pulse mode. Measurements yielded an angular resolution of 2.5deg and energy resolution of 12.9% at 662 keV. The camera motion is totally automated and controlled by stepping motors connected to a remote computer. Several 2D images of radioactive sources have been acquired in fields of up to 400 mR/h and energies up to 2.75 MeV. Some of the images demonstrate the ability of the camera to image a polychromatic field. (orig.)

  6. Radionuclide first-pass angiography using gold-195m and a digital mobile gamma camera

    International Nuclear Information System (INIS)

    This paper describes the evaluation of ventricular function in 25 patients by first-pass radionuclide angiography with the ultrashort-lived radionuclide gold-195m produced by a bedside, mobile /sup 195m/Au//sup 195m/Au generator. A comparison has been made between a stationary, large-field-of-view gamma camera and a digital, mobile, small-field-of-view camera. The suitability of this technique to assess rapid evolutionary changes of ventricular performance is discussed. With examples of applications of nitroglycerin and hydralazine, the ability of this method to monitor the physiological time sequence of ventricular function after interventions is illustrated noninvasively and with lower radiation burden than with conventional techniques

  7. Physical characterization of a discrete pixel gamma camera; Caracterizacion fisica de una gammacamara de pixel discreto

    Energy Technology Data Exchange (ETDEWEB)

    Saldana Gutierrez, P.; Puchal Ane, R.

    2012-07-01

    The development of new semiconductor materials for the last twenty years has led to the appearance of compounds such as CdTe (Cadmium Telluride) or CZT (Cadmium-Zinc Telluride), which have application in c-ray detectors in nuclear medicine. These new semiconductors have, among other properties that make them interesting, an excellent spatial and energy resolution, can operate at room temperature and high efficiency. The aim of this work is the physical characterization of the CdTe based MINICAM 2 (EURORAD) portable semiconductor gamma camera, subjecting it to some of the NEMA standard tests. We studied the spatial and energy resolution, uniformity and sensitivity, using different radioisotopes. The obtained results showed a higher spatial and energy resolution of the camera compared to the NaI(Tl) scintillator crystals, while the performances were similar in uniformity and sensitivity tests. (Author)

  8. Use of calibration methodology of gamma cameras for the workers surveillance using a thyroid simulator

    International Nuclear Information System (INIS)

    In Mexico there are a significant number of nuclear medicine centers in operation. For what the accidents risk related to the transport and manipulation of open sources used in nuclear medicine can exist. The National Institute of Nuclear Research (ININ) has as objective to establish a simple and feasible methodology for the workers surveillance related with the field of the nuclear medicine. This radiological surveillance can also be applied to the public in the event of a radiological accident. To achieve this it intends to use the available equipment s in the nuclear medicine centers, together with the neck-thyroid simulators elaborated by the ININ to calibrate the gamma cameras. The gamma cameras have among their component elements that conform spectrometric systems like the employees in the evaluation of the internal incorporation for direct measurements, reason why, besides their use for diagnostic for image, they can be calibrated with anthropomorphic simulators and also with punctual sources for the quantification of the radionuclides activity distributed homogeneously in the human body, or located in specific organs. Inside the project IAEA-ARCAL-RLA/9/049-LXXVIII -Procedures harmonization of internal dosimetry- where 9 countries intervened (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru, Uruguay and Spain). It was developed a protocol of cameras gamma calibration for the determination in vivo of radionuclides. The protocol is the base to establish and integrated network in Latin America to attend in response to emergencies, using nuclear medicine centers of public hospitals of the region. The objective is to achieve the appropriate radiological protection of the workers, essential for the sure and acceptable radiation use, the radioactive materials and the nuclear energy. (Author)

  9. Processing Gamma-Camera Data Obtained from an Off-Line System

    International Nuclear Information System (INIS)

    A system for off-line collection of data from a gamma camera in a form suitable for computer analysis is described. The co-ordinates from the gamma camera are digitized by analogue-to-digital convertors (6 bits in 10 μsec), buffered by two core stores (6 bits X 512 words), and then transferred to computer- compatible magnetic tape. There is no on-line display facility. The records are processed on a powerful batch-processing computer (CDC 6600). A program for carrying out detailed analysis of the data is described. The data are arranged as a series of 64 x 64 arrays on disc, one for each time interval. The program provides for the statistical smoothing of the random data, correction for the inherent non-uniformity of the gamma camera, and for printing the processed pictures by the computer as a series of density-graded symbols. Dynamic studies are carried out by monitoring the count-rate over specific regions, which may be regular or irregular. Irregular regions are specified by the co-ordinates of the boundary in terms of the 64 x 64 array printed on the picture. Control subroutines are used for carrying out the analysis for specific clinical procedures including kidney, heart and stomach investigations. These involve smoothing of statistical fluctuations of time curves and addition, subtraction and differentiation of time varying curves. In one case the computer has been programmed to identify the regions of interest for dynamic analysis. The program is designed for ease of operation. The relevant operations associated with each particular investigation can be selected by means of a small number of control cards. (author)

  10. A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging

    International Nuclear Information System (INIS)

    The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We developed a software tool to reconstruct the target's three-dimensional distribution of emission from a set of planar projections, based on the maximum likelihood algorithm. We present details on the hardware and software implementation. We imaged phantoms and heart and kidneys of rats. When using pinhole collimators, the spatial resolution and sensitivity of the imaging system depend on parameters such as the detector-to-collimator and detector-to-target distances and pinhole diameter. In this study, we reached an object voxel size of 0.6 mm and spatial resolution better than 2.4 and 1.7 mm full width at half maximum when 1.5- and 1.0-mm diameter pinholes were used, respectively. Appropriate sensitivity to study the target of interest was attained in both cases. Additionally, we show that as few as 12 projections are sufficient to attain good quality reconstructions, a result that implies a significant reduction of acquisition time and opens the possibility for radiotracer dynamic studies. In conclusion, a high resolution single photon emission computed tomography (SPECT) system was developed using a commercial clinical gamma camera, allowing the acquisition of detailed volumetric images of small animal organs. This type of system has important implications for research areas such as Cardiology, Neurology or Oncology. (author)

  11. Modeling an Interwoven Collimator for A 3D Endocavity Gamma Camera

    Directory of Open Access Journals (Sweden)

    Terry Lall

    2016-02-01

    Full Text Available Positron emission tomography (PET and single-photon emission-computed tomography (SPECT are important nuclear-medical imaging tools in diagnosing cancers and creating effective treatment plans. Commercially imaging systems are operated externally and can create 3D images of the whole body or of specific organs by rotating the gamma-ray detectors, and then employing software to reconstruct the 3D images from the multiple 2D projections at different angles of view. However, their uses in intraoperative environments or for imaging specific small organs, e.g., the prostate, ovary, and cervix, are limited because of their bulky designs and the long working-distance, hence causing low efficiency and poor spatial-resolution. In such situations, compact imaging devices, e.g., the trans-rectal gamma camera developed at Brookhaven National Laboratory (BNL and Hybridyne Imaging Technologies, are preferable for detecting intra-prostatic tumors. The camera uses pixilated cadmium zinc telluride (CdZnTe detectors with a matched parallel-hole collimator. However, their lack of 3D imaging capability limits their use in clinics, because the acquired images cannot be interpreted easily due to missing depth information. Given the constraint on space in such operations, the traditional 3D-image acquisition methods are impractical. For this reason, we designed an interwoven collimator dedicated for 3D imaging using an endocavity probe. This novel collimator allows us to take two or multiple views of a specific organ or tissue without rotating the camera. At the first stage of design for the collimator, we carried out Monte-Carlo simulations to study the response of the collimator and the attached detectors to gamma rays, and then developed a maximum-likelihood-based algorithm for reconstructing 3D images. In this paper, we detail our modeling of the collimator on a cluster Linux computer, and discuss the imaging capability of this novel collimator.

  12. A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Mejia, J.; Galvis-Alonso, O.Y., E-mail: mejia_famerp@yahoo.com.b [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Biologia Molecular; Castro, A.A. de; Simoes, M.V. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Clinica Medica; Leite, J.P. [Universidade de Sao Paulo (FMRP/USP), Ribeirao Preto, SP (Brazil). Fac. de Medicina. Dept. de Neurociencias e Ciencias do Comportamento; Braga, J. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Div. de Astrofisica

    2010-11-15

    The main objective of the present study was to upgrade a clinical gamma camera to obtain high resolution tomographic images of small animal organs. The system is based on a clinical gamma camera to which we have adapted a special-purpose pinhole collimator and a device for positioning and rotating the target based on a computer-controlled step motor. We developed a software tool to reconstruct the target's three-dimensional distribution of emission from a set of planar projections, based on the maximum likelihood algorithm. We present details on the hardware and software implementation. We imaged phantoms and heart and kidneys of rats. When using pinhole collimators, the spatial resolution and sensitivity of the imaging system depend on parameters such as the detector-to-collimator and detector-to-target distances and pinhole diameter. In this study, we reached an object voxel size of 0.6 mm and spatial resolution better than 2.4 and 1.7 mm full width at half maximum when 1.5- and 1.0-mm diameter pinholes were used, respectively. Appropriate sensitivity to study the target of interest was attained in both cases. Additionally, we show that as few as 12 projections are sufficient to attain good quality reconstructions, a result that implies a significant reduction of acquisition time and opens the possibility for radiotracer dynamic studies. In conclusion, a high resolution single photon emission computed tomography (SPECT) system was developed using a commercial clinical gamma camera, allowing the acquisition of detailed volumetric images of small animal organs. This type of system has important implications for research areas such as Cardiology, Neurology or Oncology. (author)

  13. Computer assisted collimation gamma camera: A new approach to imaging contaminated tissues

    International Nuclear Information System (INIS)

    Measurement systems with the capability of imaging tissues contaminated with radioactive materials would find relevant applications in medical physics research and possibly in health physics. The latter in particular depends critically on the performance achieved for sensitivity and spatial resolution. An original approach of computer assisted collimation gamma camera (French acronym CACAO) which could meet suitable characteristics has been proposed elsewhere. CACAO requires detectors with high spatial resolution. The present work was aimed at investigating the application of the CACAO principle on a laboratory testing bench using silicon detectors made of small pixels. (author)

  14. Easy method to measure radioactive waste with a gamma-camera detector

    International Nuclear Information System (INIS)

    The aim of this technical note is to evaluate an easy method to measure 99mTc samples with an activity of 1000, 100 and 10 Bq/L. This study is performed with a gamma camera detector in two departments of nuclear medicine in Avignon and in Nimes. We develop a procedure to measure99mTc radioactive waste at the two hospitals output in accordance with the D.G.S./D.H.O.S. no. 2001/323 circular requests of the Ministry for Employment and Solidarity. (authors)

  15. Single photon emission computed tomography of the brain with a rotating gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Biersack, H.J.; Knopp, R.; Winkler, C.; Wappenschmidt, J.

    1981-08-01

    In 471 patients SPECT of the brain was performed in addition to conventional serial brain scintigraphy using a rotating gamma camera (GAMMATOME T 9000). 23 patients had tumorous lesions, 26 had vascular lesions, and 422 patients revealed normal brain findings. 5 of the 23 patients with tumorous lesion and 5 of the 12 patients with vascular lesion (anamnesis shorter than 4 weeks) showed positive SPECT results but false negative conventional brain scans. Specificity could be improved up to 98% (412 out of 422 patients) using SPECT and conventional scintigraphy.

  16. A 3D high-resolution gamma camera for radiopharmaceutical studies with small animals

    CERN Document Server

    Loudos, G K; Giokaris, N D; Styliaris, E; Archimandritis, S C; Varvarigou, A D; Papanicolas, C N; Majewski, S; Weisenberger, D; Pani, R; Scopinaro, F; Uzunoglu, N K; Maintas, D; Stefanis, K

    2003-01-01

    The results of studies conducted with a small field of view tomographic gamma camera based on a Position Sensitive Photomultiplier Tube are reported. The system has been used for the evaluation of radiopharmaceuticals in small animals. Phantom studies have shown a spatial resolution of 2 mm in planar and 2-3 mm in tomographic imaging. Imaging studies in mice have been carried out both in 2D and 3D. Conventional radiopharmaceuticals have been used and the results have been compared with images from a clinically used system.

  17. General purpose dynamic phantom for gated, computer aided gamma camera evaluation

    International Nuclear Information System (INIS)

    A dynamic phantom with broad applications in testing computer aided gamma camera imaging systems is directed. The phantom employs a rotating disk which may be used to carry a distribution of absorbers or of radioactive sources. The disk is directly driven by a variable speed DC motor with a coupled tachometer for servo-controlled speed regulation. Data are presented for a variety of absorber and source distributions, including simulated cardiac dynamics. The system can be used to validate hardware and software integrity including computer gating circuits, linearity of intensity response, edge detection, and ejection fraction calculations

  18. A general purpose dynamic phantom for gated, computer-aided gamma camera evaluation

    International Nuclear Information System (INIS)

    A dynamic phantom with broad applications in testing computer-aided gamma camera imaging systems is described. The phantom employs a rotating disc which may be used to carry a distribution of absorbers or of radioactive sources. The disc is directly driven by a variable speed DC motor with a coupled tachometer for servo-controlled speed regulation. Data are presented for a variety of absorber and source distributions, including simulated cardiac dynamics. The system can be used to validate hardware and software integrity including computer gating circuits, linearity of intensity response, edge detection and ejection fraction calculations. (author)

  19. A system on chip solution for processing of gamma camera images for thyroid uptake studies

    International Nuclear Information System (INIS)

    Nuclear medical Imaging modalities such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are non-invasive, in-vivo and functional. Molecular imaging technologies that have produced promising results for specific identification of cancer and other investigations which need specialized diagnosis with Gamma Camera (GC) like thyroid scan, bone hot spot study etc. This is due to their unique ability to sense and visualize increased biochemical changes in malignancy zone as compared to healthy tissue well before structural changes can occur

  20. COMPACT CdZnTe-BASED GAMMA CAMERA FOR PROSTATE CANCER IMAGING

    Energy Technology Data Exchange (ETDEWEB)

    CUI, Y.; LALL, T.; TSUI, B.; YU, J.; MAHLER, G.; BOLOTNIKOV, A.; VASKA, P.; DeGERONIMO, G.; O' CONNOR, P.; MEINKEN, G.; JOYAL, J.; BARRETT, J.; CAMARDA, G.; HOSSAIN, A.; KIM, K.H.; YANG, G.; POMPER, M.; CHO, S.; WEISMAN, K.; SEO, Y.; BABICH, J.; LaFRANCE, N.; AND JAMES, R.B.

    2011-10-23

    In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

  1. Compact CdZnTe-Based Gamma Camera For Prostate Cancer Imaging

    International Nuclear Information System (INIS)

    In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high false-positive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integrated-circuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

  2. Compact CdZnTe-based gamma camera for prostate cancer imaging

    Science.gov (United States)

    Cui, Yonggang; Lall, Terry; Tsui, Benjamin; Yu, Jianhua; Mahler, George; Bolotnikov, Aleksey; Vaska, Paul; De Geronimo, Gianluigi; O'Connor, Paul; Meinken, George; Joyal, John; Barrett, John; Camarda, Giuseppe; Hossain, Anwar; Kim, Ki Hyun; Yang, Ge; Pomper, Marty; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John; LaFrance, Norman; James, Ralph B.

    2011-06-01

    In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

  3. Survey of potential use of dynamic line phantom for quality control of Gamma camera

    International Nuclear Information System (INIS)

    Different phantoms, used to evaluate the essential for image quality parameters of gamma cameras in order to avoid artefacts, are presented. The prices are significant and it is a sensible approach to optimise the type and number of phantoms necessary for quality control. Among all phantoms the price of 'Dynamic Line Phantom' (DLP) is impressive, but it is announced to substitute several 'passive' and 'active' phantoms. The goal of this paper is to justify this statement. The programs, based on image profile are discussed in the paper and the practical uses of the different programs are given

  4. Approaches to contamination problems of agricultural land using Na(I) Tl spectrometer and gamma camera

    International Nuclear Information System (INIS)

    The severe accident of Fukushima Daiichi Nuclear Power Plant made a large area of agricultural land contaminated with radioactive cesium (Cs-134 and 137). Quantitative analysis for radioactivity (discriminating for Cs-134 and Cs-137) taken in vegetables from the land was carried out using NaI (Tl) scintillation spectrometer. Development of gamma camera for their imaging due to Cs 137 was performed. The shape of the peaks in the spectrum, baseline suppression, a solution of lines overlapping, enhancement of high-resolution were studied. Furthermore, the effect of water on cesium absorbing and transferring process from the root to the tissue was studied. (S. Ohno)

  5. Further developments on an ISPA-camera for gamma-rays in nuclear medicine

    CERN Document Server

    D'Ambrosio, C; Gys, Thierry; Leutz, H; Piedigrossi, D; Puertolas, D; Rosso, E

    1999-01-01

    The ISPA (imaging silicon pixel array)-tube is a position-sensitive hybrid photon detector. Originally developed for high energy physics purposes, it has also been used for biomedical applications. Two kinds of ISPA-tube prototypes have been tested successfully in the field of gamma ray imaging. The current developments aim at obtaining a detector dedicated to single photon emission imaging. In this paper, we shall present the very first use in a gamma-camera of a new ISPA-tube prototype having an increased active input surface of 40 mm diameter and a de-magnifying electron optics. The expected advantages of an ISPA-tube equipped with an input window made out of YAP-crystal will also be pointed out by presenting results obtained with a hybrid photomultiplier tube equipped with such a YAP window. (12 refs).

  6. Study of a new architecture of gamma cameras with Cd/ZnTe/CdTe semiconductors; Etude d'une nouvelle architecture de gamma camera a base de semi-conducteurs CdZnTe /CdTe

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, L

    2007-11-15

    This thesis studies new semi conductors for gammas cameras in order to improve the quality of image in nuclear medicine. The chapter 1 reminds the general principle of the imaging gamma, by describing the radiotracers, the channel of detection and the types of Anger gamma cameras acquisition. The physiological, physical and technological limits of the camera are then highlighted, to better identify the needs of future gamma cameras. The chapter 2 is dedicated to a bibliographical study. At first, semi-conductors used in imaging gamma are presented, and more particularly semi-conductors CDTE and CdZnTe, by distinguishing planar detectors and monolithic pixelated detectors. Secondly, the classic collimators of the gamma cameras, used in clinical routine for the most part of between them, are described. Their geometry is presented, as well as their characteristics, their advantages and their inconveniences. The chapter 3 is dedicated to a state of art of the simulation codes dedicated to the medical imaging and the methods of reconstruction in imaging gamma. These states of art allow to introduce the software of simulation and the methods of reconstruction used within the framework of this thesis. The chapter 4 presents the new architecture of gamma camera proposed during this work of thesis. It is structured in three parts. The first part justifies the use of semiconducting detectors CdZnTe, in particular the monolithic pixelated detectors, by bringing to light their advantages with regard to the detection modules based on scintillator. The second part presents gamma cameras to base of detectors CdZnTe (prototypes or commercial products) and their associated collimators, as well as the interest of an association of detectors CdZnTe in the classic collimators. Finally, the third part presents in detail the HiSens architecture. The chapter 5 describes both software of simulation used within the framework of this thesis to estimate the performances of the Hi

  7. Two-dimensional diced scintillator array for innovative, fine-resolution gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Fujita, T., E-mail: t_fujita@fuji.waseda.jp [Research Institute for Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan); Kataoka, J.; Nishiyama, T. [Research Institute for Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555 (Japan); Ohsuka, S. [Central Research Laboratory, Hamamatsu Photonics K.K., 5000, Hirakuchi, Hamakita-ku, Hamamatsu, Shizuoka (Japan); Nakamura, S. [Solid State Division, Hamamatsu Photonics K.K., 1126-1, Ichino-cho, Higashi-ku, Hamamatsu, Shizuoka (Japan); Yamamoto, S. [Nagoya University Graduate School of Medicine, 1-1-20, Daikominami, Higashi-ku, Nagoya-shi, Aichi 461-8673 (Japan)

    2014-11-21

    We are developing a technique to fabricate fine spatial resolution (FWHM<0.5mm) and cost-effective photon counting detectors, by using silicon photomultipliers (SiPMs) coupled with a finely pixelated scintillator plate. Unlike traditional X-ray imagers that use a micro-columnar CsI(Tl) plate, we can pixelate various scintillation crystal plates more than 1 mm thick, and easily develop large-area, fine-pitch scintillator arrays with high precision. Coupling a fine pitch scintillator array with a SiPM array results in a compact, fast-response detector that is ideal for X-ray, gamma-ray, and charged particle detection as used in autoradiography, gamma cameras, and photon counting CTs. As the first step, we fabricated a 2-D, cerium-doped Gd{sub 3}Al{sub 2}Ga{sub 3}O{sub 12} (Ce:GAGG) scintillator array of 0.25 mm pitch, by using a dicing saw to cut micro-grooves 50μm wide into a 1.0 mm thick Ce:GAGG plate. The scintillator plate is optically coupled with a 3.0×3.0mm pixel 4×4 SiPM array and read-out via the resistive charge-division network. Even when using this simple system as a gamma camera, we obtained excellent spatial resolution of 0.48 mm (FWHM) for 122 keV gamma-rays. We will present our plans to further improve the signal-to-noise ratio in the image, and also discuss a variety of possible applications in the near future.

  8. Recent progress in gamma-ray imaging by using a Si/CdTe semiconductor Compton camera

    International Nuclear Information System (INIS)

    Dust, containing radioactive materials, was dispersed following the Fukushima nuclear power plant accident in March 2011. Gamma-rays were emitted in the process when unstable nuclei in the materials decayed. The visualization of the distribution of radioactive materials is regarded as an important technology in the process of decontamination. A gamma-ray camera, which is based on the concept of reconstructing Compton scatterings, which take place in the detector, is known as a Compton camera and works in the energy range from a few hundred keV to a few MeV. 40 years after the first proposal for such a camera, Compton cameras are now being demonstrated as a real gamma-ray imager that can be used in the Fukushima area. In addition to monitoring hotspots in radiation sites, the camera could be used in various fields, such as medicine and non-destructive analyses. In this paper, we describe recent progress in Gamma-ray imaging by using a semiconductor Compton camera based on the technologies of Si and CdTe semiconductor detectors. (author)

  9. Comparison of the barium test meal and the gamma camera scanning technic in measuring gastric emptying

    International Nuclear Information System (INIS)

    In 21 patients with nonresected stomachs and symptoms of delayed gastric emptying, obstruction was excluded by upper gastrointestinal series and upper endoscopy; all had abnormal results of barium test meal (BTM) study. Each had repeat BTM after the administration of 10 mg of metoclopramide. Each patient also had two gamma camera studies after a technetium Tc 99m sulfur colloid labeled meal; normal saline or metoclopramide was administered before each test in a blinded and random manner. Half-time (T 1/2) and percentage of isotope remaining at six hours (GC6) were recorded. Ten asymptomatic controls had a gamma camera scanning study, and seven of these had a BTM. Nine of 19 patients had a T 1/2 in the normal range, and in 12 of 19 patients the GC6 was in the normal range. The magnitude of retention of barium at six hours on the BTM did not correlate with the T 1/2 (r = 0.076) or the GC6 (r = 0.296). Thus, these tests were not comparable in this study. By regression analysis, a significant reduction was shown in the amount of retained food and barium (P < .01), the T 1/2 (P < .01), and the GC6 (P < .01) after intramuscular administration of metoclopramide, indicating that both tests were able to evaluate the effects of this drug

  10. Realisation of a gamma emission tomograph by a servo-controlled camera and bed

    International Nuclear Information System (INIS)

    We took part in the building of a transverse axial emission tomograph intended for nuclear medicine. The following three points were dealt with: mathematical, choice of processing algorithm; electronic, development of equipment; experimental, testing of the system built. On the mathematical side, following a survey of reconstruction methods, we studied the use of a reconstruction algorithm after filtering of the projections by convolution which gives a good spatial resolution. We also proposed a means to solve the computing time/quality of image problem, leading to a satisfactory result within a shorter total investigation time. In this way the computing time has been reduced by a factor three. In the electronics field we built an interface between the bed, the gamma camera and the computer already in the laboratory. The present instrument corresponds to version no. 2. The system control the bed and gamma camera which are operated from the computer. Experimentally we were able on checking the calculations with a phantom made up of small emitting sources, to prove by finding the exact spot our ability to locate active foci on the patient. While the results obtained are encouraging from the image restitution viewpoint, the study of problems related to self-absorption inside the organ and those of statistical noise have still to be continued

  11. Daily quality check: its importance in clinical SPECT gamma camera imaging

    International Nuclear Information System (INIS)

    Performance characteristics of 'SPECT gamma camera systems' (GCS) are likely to vary with time. This is evaluated by running a defined Quality Control Program (QCP) which includes set of tests. Basically, daily quality check is to ensure detection of the changes in the performance of SPECT GCS that may adversely affect the interpretation of the clinical studies. These quality parameters gives Technologist/ Physicist/Nuclear Medicine Specialist the data with which to decide whether: a) to continue image patient normally. b) to image patients while putting in a call to have the system serviced, or rectified. c) to put off the imaging of the patients until the system has been rectified. In this study we share our experience of daily quality checks (DQC) of the parameters for evaluating the performance of both the detectors of gamma camera comprising of 'Peaking status' and 'Extrinsic flood images' over a period of six years, before the actual acquisition of the patient study was allowed. These parameters have been our indicators for deciding whether to proceed normally with the equipment or to send a call to service engineer or to put off the machine

  12. Computer-controlled gamma-camera examination of human renal allografts using 123I-hippuran

    International Nuclear Information System (INIS)

    Human kidney transplants with ischemic damage, acute rejection and urinary flow obstruction were examined by a computer-linked gamma-camera technique using 123I-Hippuran. Serial scintigrams were produced and separate net time/activity curves for the cortex, medulla and pelvis (regional renograms) were constructed by a subtraction technique. In all the kidneys there was a significant uptake of the isotope. The scintigrams provided a morphologic picture of the graft and the upper urinary tract with high geometric resolution. Regional renograms demonstrated a different intrarenal distribution of the isotope in each of the three complications. Thus, in ischemic injury and acute rejection the isotope was retained in the cortex, with an abnormally low accumulation in the medulla and pelvis. In urinary tract obstruction, on the other hand, the isotope cleared normally from the cortex but accumulated gradually in the pelvis. Thus, the accumulation curves obtained with conventionel 131I-Hippuran renography in all three conditions depend on two different mechanisms. Computer-controlled gamma-camera examination using 123I-Hippuran offers a means of distinguishing ischemic damage and acute rejection from urinary flow obstruction. (orig.)

  13. Calculation of renal depth by conjugate-view method in dual-head gamma camera

    International Nuclear Information System (INIS)

    In this study, we developed a new method for the determination of renal depth with anterior and posterior renal scintigram in a dual-head gamma camera, considering the attenuation factor e-μx of the conjugate-view method. We developed abdomen and kidney phantoms to perform experiments using 99mTc-DMSA. The phantom images were obtained parallel-hole, low-energy, high-resolution collimators (ICONf, Siemens). The equation was derived from the linear integration of emission Υ-ray considering attenuation from the posterior abdomen to the anterior abdomen phantom surface. The program for measurement was developed by Microsoft Visual C++ 6.0. Renal depths of the phantoms were derived from the derived equations and compared with the exact geometrical values. Differences between the measured and the calculated values were the range of 0.1 to 0.7 cm (0.029±0.15cm, mean ±S.D.). The present study showed that the use of the derived equations for renal depth measurements, combined with quantitative planar imaging using dual-head gamma camera, could provide more accurate results for individual variation than the conventional method

  14. SiPM arrays and miniaturized readout electronics for compact gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Dinu, N., E-mail: dinu@lal.in2p3.fr [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Imando, T. Ait; Nagai, A. [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Pinot, L. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France); Puill, V. [Laboratory of Linear Accelerator, IN2P3, CNRS, Orsay (France); Callier, S. [Omega Microelectronics Group, CNRS, Palaiseau (France); Janvier, B.; Esnault, C.; Verdier, M.-A. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France); Raux, L. [Omega Microelectronics Group, CNRS, Palaiseau (France); Vandenbussche, V.; Charon, Y.; Menard, L. [Laboratory of Imaging and Modelisation in Neurobiology and Cancerology, IN2P3, CNRS, Orsay (France)

    2015-07-01

    This article reports on the design and features of a very compact and light gamma camera based on SiPM arrays and miniaturized readout electronics dedicated to tumor localization during radio-guided cancer surgery. This gamma camera, called MAGICS, is composed of four (2×2) photo-detection elementary modules coupled to an inorganic scintillator. The 256 channels photo-detection system covers a sensitive area of 54×53 m{sup 2}. Each elementary module is based on four (2×2) SiPM monolithic arrays, each array consisting of 16 SiPM photo-sensors (4×4) with 3×3 mm{sup 2} sensitive area, coupled to a miniaturized readout electronics and a dedicated ASIC. The overall dimensions of the electronics fit the size of the detector, enabling to assemble side-by-side several elementary modules in a close-packed arrangement. The preliminary performances of the system are very encouraging, showing an energy resolution of 9.8% and a spatial resolution of less than 1 mm at 122 keV.

  15. Is it possible to do radiopharmaceutical quality control with a gamma camera

    International Nuclear Information System (INIS)

    All of the imaging studies in nuclear medicine start with a suitable radiopharmaceutical preparation step. In radiopharmaceutical synthesis, an organic or biochemical molecule is combined with a radioactive element to form a complex. This process is known as radiolabeling (1). In a radiopharmaceutical labeling study, it is important to realize that whether or not the radiolabeled chemical complex is in the expected radiochemical form has a vital role for all the nuclear medicine imaging processes. The common method of radiopharmaceutical quality control is the chromatographic analysis such as PC, TLC, and HPLC. In nuclear medicine practice, application of these methods is called radiopharmaceutical quality control(2). The agrement of results obtained from such chromatographic analysis methods with the criterions given in United States Pharmacopea (USP) means the regulatory permission of the use of that radiopharmaceutical in proposed applications(3). In this study separation of several labeled radiopharmaceuticals were demonstrated by using standard support materials and solvents. After dying the chromatographic support material, a gamma camera (TOSHIBA GCA-602A) was used to do radiation counting and static imaging for 2 minutes. These images, then, was divided into rectangular pieces (5 x 25 in pixel) and Region of Interest (ROI) process was applied to them. The percent labeling yields were calculated by plotting total count for each area against the number of area. It was also demonstrated that the Rf values obtained from gamma camera studies were in agreement with the Rf values obtained with classical methods

  16. Hepatic scintiangiography using gamma camera system: diagnosis of hepatomas and liver abscess

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Choon Yul; Bahk, Yong Whee; Yoon, Sei Chul [Catholic Medical College, Seoul (Korea, Republic of)

    1980-12-15

    The purpose of this investigation is to distinguish hepatomas from the liver abscess by scintiangiography using Anger camera system. Ninety-five patients were imaged by Gamma camera system in St. Mary's Hospital, Catholic Medical College between May 1979 and January 1980 and their medical records were reviewed in detail. Of a total of 95 patients 38 patients were proved by histology. The patients were placed supine under Gamma camera detector head to view the anterior projection of the liver and spleen. Following an intravenous bolus injection of 10 mCi Tc-99m-phytate in volume of 3 {approx} 4ml, rapid sequential imaging 1 second duration was obtained for 16 and 30 seconds, and recorded 16 to 30 images in one film. The 4 {approx} 5 scintigraphic images obtained from the time of the first appearance of radioactivity in the abdominal aorta until its disappearance from the abdominal aorta were classified as the arterial phase of the study. In normal arterial phase, there is little or no radioactivity in the hepatic bed, compared to the lungs, heart and right kidney. When a radioactivity (early arterial staining) is depicted in the hepatic bed in the arterial phase of the scintiangiography, neoplastic condition is highly suggested. Hepatoma (47 cases) and metastasis (4 cases) show that extremely high concentration of radioactivity (early arterial staining) was noted in arterial phase in 44 cases and equivocal in 7 cases. A total of early arterial staining is concerted into the cold area in the static liver imaging. This early arterial staining is thought to be due definitely to neovascularization and feeding arteries of tumors. Liver abscess (4 cases) shows that appearance of radioactivity in the hepatic scintiangiogram as a whole was normal, except for reactive rim of hyperemia in arterial and early venous phases, but the area identified on the static liver imaging as a cold area. The hepatic scintiangiography plus static liver imaging using gamma camera system

  17. First-pass radionuclide angiography using a multiwire gamma camera and tantalum-178

    International Nuclear Information System (INIS)

    A portable multiwire gamma camera (MWGC) with enhanced imaging characteristics relative to conventional sodium iodide camera has been evaluated with 178Ta, a short-lived, generator-produced radioisotope (half-life 9.3 min). First-pass radionuclide angiography (FPRA) was performed and results were compared to those obtained with FPRA using a multicrystal camera (MCC) and /sup 99m/Tc in 38 patients. The overall left ventricular count sensitivity (countsmCisecmillisteradians [msr]) was significantly higher with MWGC178Ta (176 +- 132 versus 108 +- 49, p less than 0.001) yielding images of higher statistics with higher resolution collimation (31 versus 63 msr). Left ventricular ejection fraction was 0.54 +- 0.18 by MWGC and 0.54 +- 0.18 by MCC with an excellent correlation between the two techniques (r = 0.94, s.e.e. = 0.06). The detection of wall motion abnormality was virtually identical with the two techniques. Intra- and interobserver reproducibility by MWGC was excellent (r = 0.99 and 0.99, respectively). Thus, this new technology provides first-pass studies of higher statistical quality and improved resolution, affording more precise assessment of left ventricular performance and likelihood of further substantial improvement by use of even higher doses of 178Ta

  18. Performance evaluation of a hand-held, semiconductor (CdZnTe)-based gamma camera

    International Nuclear Information System (INIS)

    We have designed and developed a small field of view gamma camera, the eZ SCOPE, based on use of a CdZnTe semiconductor. This device utilises proprietary signal processing technology and an interface to a computer-based imaging system. The purpose of this study was to evaluate the performance of the eZ scope in comparison with currently employed gamma camera technology. The detector is a single wafer of 5-mm-thick CdZnTe that is divided into a 16 x 16 array (256 pixels). The sensitive area of the detector is a square of dimension 3.2 cm. Two parallel-hole collimators are provided with the system and have a matching (256 hole) pattern to the CdZnTe detector array: a low-energy, high-resolution parallel-hole (LEHR) collimator fabricated of lead and a low-energy, high-sensitivity parallel-hole (LEHS) collimator fabricated of tungsten. Performance measurements and the data analysis were done according to the procedures of the NEMA standard. We also studied the long-term stability of the system with continuous use and variations in ambient temperature. Results were as follows. Intrinsic energy resolution: 8.6% FWHM at 141 keV. Linearity: There was excellent linearity between the observed photopeaks and the known gamma ray energies for the given isotopes. Intrinsic system uniformity: For the central field of view, the integral uniformity and the differential uniformity were, respectively, 1.6% and 1.3% with the LEHR collimator and 1.9% and 1.2% with the LEHS collimator. System spatial resolution: The FWHM measurements made at the surface of the collimator were 2.2 mm (LEHR) and 2.9 mm (LEHS). Contrast test: The average S/N ratios (i.e. counts in the irradiated pixel divided by counts in the surrounding pixels) for the inner ring pixels (8)/outer ring pixels (16) using the LEHS collimator and LEHR collimator were 3.2%/0.2% and 3.7%/0.3%, respectively. Count rate characteristics: We could not determine the maximum count rate and the 20% loss count rate from these data

  19. LaBr{sub 3}:Ce scintillation gamma camera prototype for X and gamma ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pani, R. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy)]. E-mail: roberto.pani@uniroma1.it; Cinti, M.N. [INFN and Department of Physics, ' La Sapienza' University, Rome (Italy); Pellegrini, R. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy); Bennati, P. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy); Betti, M. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy); Vittorini, F. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy); Mattioli, M. [INFN and Department of Physics, ' La Sapienza' University, Rome (Italy); Trotta, G. [INFN and Department of Experimental Medicine, University of Rome ' La Sapienza' , Viale Regina Elena 324, 00161 Rome (Italy); Orsolini Cencelli, V. [INFN and ' Roma III' University, Rome (Italy); Scafe, R. [INFN and ENEA Casaccia Research Center, Rome (Italy); Navarria, F. [INFN and Department of Physics, University of Bologna (Italy); Bollini, D. [INFN and Department of Physics, University of Bologna (Italy); Baldazzi, G. [INFN and Department of Physics, University of Bologna (Italy); Moschini, G. [INFN and Department of Physics, University of Padova (Italy); De Notaristefani, F. [INFN and Department of Electronics Engineering, ' Roma III' University, Rome (Italy)

    2007-06-11

    LaBr{sub 3}:Ce has been showing very promising characteristics as gamma ray imager and spectrometer. In particular its excellent energy resolution values (6% at 140 keV and {approx}3% FWHM at 662 keV), obtained when coupled to a PMT, make it the major competitor of semiconductor detectors working at room temperature. In order to improve its imaging performances, the LaBr{sub 3}:Ce can easily work as continuous detector allowing sub-millimeter spatial resolution values at 140 keV photon energy when coupled to a Position Sensitive PMT. Further interesting characteristics like a short scintillation decay time (16 ns), a very high light yield (63 000 photons/MeV) and a low afterglow are attracting the scientific community for the potential improvement of a wide range of applications in medicine like PET, SPECT and CT instrumentation. In this paper, we present some preliminary imaging results obtained by coupling H8500 Hamamatsu Flat Panel PMT to two LaBr{sub 3}:Ce crystals with 50x50 mm{sup 2} area, 5 and 10 mm thickness respectively. With the aim to propose a single detector able to combine functional information, for example from Single Photon Emission technique, with the morphological ones from X-ray imaging the spatial resolution results obtained in the energy range between 30 and 302 keV are analyzed and discussed. We obtained very interesting spatial resolution results for gamma ray energy value greater than 60 keV (better than 1 mm, intrinsic value), while in the energy range proper to X-ray applications, like RX-Mammography (about 30 keV), the spatial resolution values resulted about 2 mm.

  20. Development of GATE Monte Carlo simulation for a dual-head gamma camera.

    Science.gov (United States)

    Momennezhad, Mehdi; Sadeghi, Ramin; Nasseri, Shahrokh

    2012-07-01

    GATE is a simulation code which is based on the Geant4 Monte Carlo code. This code was developed for simulation of nuclear medicine imaging systems. Our aim in this study was to use and validate GATE for simulating a Siemens E.Cam gamma camera. A dual-head gamma camera was used for modeling with GATE. Each head consisted of a collimator, aluminum layer, crystal, and head shielding. The back compartment consisted of photomultiplier tubes and electronic circuits behind the crystal. The photoelectric effect and Compton and Rayleigh scatter were included in the gamma transport process. The simulation validity was examined by comparison of measured parameters with calculated data including the energy spectrum, energy, spatial resolution, and sensitivity. To evaluate the imaging system, we compared the simulated and experimental images of a phantom. The simulated and measured energy spectra agreed well with regard to the position and height of the photopeak at 140 keV. The FWHMs at 140 keV were calculated to be equal to 14.10 and 13.37 keV, respectively. The energy resolutions were 10.07 and 9.55%, and the sensitivities were 8.68 × 10(-5) and 8.69 × 10(-5) cps/MBq, respectively, for the simulated and measured results. The spatial resolution and imaging tests for a point, line, and node phantom showed good agreement between the simulated and measured results. Overall, the results showed good agreement between the measured and the simulated data. There was also excellent agreement between computational and actual images. This study demonstrated the flexibility and accuracy of GATE in SPECT simulation. PMID:22588590

  1. A novel Compton camera design featuring a rear-panel shield for substantial noise reduction in gamma-ray images

    International Nuclear Information System (INIS)

    After the Japanese nuclear disaster in 2011, large amounts of radioactive isotopes were released and still remain a serious problem in Japan. Consequently, various gamma cameras are being developed to help identify radiation hotspots and ensure effective decontamination operation. The Compton camera utilizes the kinematics of Compton scattering to contract images without using a mechanical collimator, and features a wide field of view. For instance, we have developed a novel Compton camera that features a small size (13 × 14 × 15 cm3) and light weight (1.9 kg), but which also achieves high sensitivity thanks to Ce:GAGG scintillators optically coupled wiith MPPC arrays. By definition, in such a Compton camera, gamma rays are expected to scatter in the ''scatterer'' and then be fully absorbed in the ''absorber'' (in what is called a forward-scattered event). However, high energy gamma rays often interact with the detector in the opposite direction - initially scattered in the absorber and then absorbed in the scatterer - in what is called a ''back-scattered'' event. Any contamination of such back-scattered events is known to substantially degrade the quality of gamma-ray images, but determining the order of gamma-ray interaction based solely on energy deposits in the scatterer and absorber is quite difficult. For this reason, we propose a novel yet simple Compton camera design that includes a rear-panel shield (a few mm thick) consisting of W or Pb located just behind the scatterer. Since the energy of scattered gamma rays in back-scattered events is much lower than that in forward-scattered events, we can effectively discriminate and reduce back-scattered events to improve the signal-to-noise ratio in the images. This paper presents our detailed optimization of the rear-panel shield using Geant4 simulation, and describes a demonstration test using our Compton camera

  2. A novel Compton camera design featuring a rear-panel shield for substantial noise reduction in gamma-ray images

    Science.gov (United States)

    Nishiyama, T.; Kataoka, J.; Kishimoto, A.; Fujita, T.; Iwamoto, Y.; Taya, T.; Ohsuka, S.; Nakamura, S.; Hirayanagi, M.; Sakurai, N.; Adachi, S.; Uchiyama, T.

    2014-12-01

    After the Japanese nuclear disaster in 2011, large amounts of radioactive isotopes were released and still remain a serious problem in Japan. Consequently, various gamma cameras are being developed to help identify radiation hotspots and ensure effective decontamination operation. The Compton camera utilizes the kinematics of Compton scattering to contract images without using a mechanical collimator, and features a wide field of view. For instance, we have developed a novel Compton camera that features a small size (13 × 14 × 15 cm3) and light weight (1.9 kg), but which also achieves high sensitivity thanks to Ce:GAGG scintillators optically coupled wiith MPPC arrays. By definition, in such a Compton camera, gamma rays are expected to scatter in the ``scatterer'' and then be fully absorbed in the ``absorber'' (in what is called a forward-scattered event). However, high energy gamma rays often interact with the detector in the opposite direction - initially scattered in the absorber and then absorbed in the scatterer - in what is called a ``back-scattered'' event. Any contamination of such back-scattered events is known to substantially degrade the quality of gamma-ray images, but determining the order of gamma-ray interaction based solely on energy deposits in the scatterer and absorber is quite difficult. For this reason, we propose a novel yet simple Compton camera design that includes a rear-panel shield (a few mm thick) consisting of W or Pb located just behind the scatterer. Since the energy of scattered gamma rays in back-scattered events is much lower than that in forward-scattered events, we can effectively discriminate and reduce back-scattered events to improve the signal-to-noise ratio in the images. This paper presents our detailed optimization of the rear-panel shield using Geant4 simulation, and describes a demonstration test using our Compton camera.

  3. A Compton scatter camera for spectral imaging of 0.5 to 3.0 MeV gamma rays

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.B.

    1994-12-31

    A prototype Compton scatter camera for imaging gamma rays has been built and tested. This camera addresses unique aspects of gamma-ray imaging at nuclear industrial sites, including gamma-ray energies in the 0.5 to 3.0 MeV range and polychromatic fields. Analytic models of camera efficiency, resolution and contaminating events are developed. The response of the camera bears strong similarity to emission computed tomography devices used in nuclear medicine. A direct Fourier based algorithm is developed to reconstruct two-dimensional images of measured gamma-ray fields. Iterative ART and MLE algorithms are also investigated. The point response of the camera to gamma rays of energies from 0.5 to 2.8 MeV is measured and compared to the analytic models. The direct reconstruction algorithm is at least ten times more efficient than the iterative algorithms are also investigated. The point response of the camera to gamma rays energies from 0.5 to 2.8 MeV is measured and compared to the analytic models. The direct reconstruction algorithm is at least ten times more efficient than the iterative algorithms and produces images that are, in general, of the same quality. Measured images of several phantoms are shown. Important results include angular resolutions as low as 4.4{degrees}, reproduction of phantom size and position within 7%, and contrast recovery of 84% or better. Spectral imaging is demonstrated with independent images from a multi-energy phantom consisting of two sources imaged simultaneously.

  4. Qualification model of the space ISGRI CdTe gamma-ray camera

    CERN Document Server

    Limousin, O; Bonnin, C; Cretolle, J; Goldwurm, A; Horeau, B; Laurent, P; Lebrun, F; Leray, J P

    2001-01-01

    A new generation of large area semiconductor based gamma-ray camera for astrophysics space application has been developed through the gamma-ray IBIS (Imager on Board INTEGRAL Satellite) telescope program, on board the ESA INTEGRAL satellite. This instrument features a coded-mask aperture imaging system, active and passive shields and two detector arrays. The first one (ISGRI : INTEGRAL Soft Gamma-Ray Imager) is made of 16384 CdTe detectors (4x4 mm large, 2 mm thick) operating at room temperature and will operate between 15 keV and 1 MeV. The second detector array (PICsIT : Pixelated CsI Telescope) is made of 4096 CsI scintillators (9.2x9.2 mm large, 30 mm high) coupled to silicon PIN photodiodes working between 150 keV and 10 MeV. IBIS combine broad band energy, spectroscopic capabilities and high spatial resolution imaging (12 arcmin) over a wide field of view (approx 20 deg. x 20 deg., 50% sensitivity). A 'flight-like' model of the detectors has been built, integrated and successfully tested. After a descri...

  5. Imaging of radiocesium uptake dynamics in a plant body by using a newly developed high-resolution gamma camera.

    Science.gov (United States)

    Kawachi, Naoki; Yin, Yong-Gen; Suzui, Nobuo; Ishii, Satomi; Yoshihara, Toshihiro; Watabe, Hiroshi; Yamamoto, Seiichi; Fujimaki, Shu

    2016-01-01

    We developed a new gamma camera specifically for plant nutritional research and successfully performed live imaging of the uptake and partitioning of (137)Cs in intact plants. The gamma camera was specially designed for high-energy gamma photons from (137)Cs (662 keV). To obtain reliable images, a pinhole collimator made of tungsten heavy alloy was used to reduce penetration and scattering of gamma photons. A single-crystal scintillator, Ce-doped Gd3Al2Ga3O12, with high sensitivity, no natural radioactivity, and no hygroscopicity was used. The array block of the scintillator was coupled to a high-quantum efficiency position sensitive photomultiplier tube to obtain accurate images. The completed gamma camera had a sensitivity of 0.83 count s(-1) MBq(-1) for (137)Cs with an energy window from 600 keV to 730 keV, and a spatial resolution of 23.5 mm. We used this gamma camera to study soybean plants that were hydroponically grown and fed with 2.0 MBq of (137)Cs for 6 days to visualize and investigate the transport dynamics in aerial plant parts. (137)Cs gradually appeared in the shoot several hours after feeding, and then accumulated preferentially and intensively in growing pods and seeds; very little accumulation was observed in mature leaves. Our results also suggested that this gamma-camera method may serve as a practical analyzing tool for breeding crops and improving cultivation techniques resulting in low accumulation of radiocesium into the consumable parts of plants. PMID:25959930

  6. Intraoperative radioguidance with a portable gamma camera: a novel technique for laparoscopic sentinel node localisation in urological malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Vermeeren, L.; Valdes Olmos, R.A.; Vogel, W.V.; Sivro, F.; Hoefnagel, C.A. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Nuclear Medicine, Amsterdam (Netherlands); Meinhardt, W.; Bex, A.; Poel, H.G. van der; Horenblas, S. [Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Department of Urology, Amsterdam (Netherlands)

    2009-07-15

    Our aim was to assess the feasibility of intraoperative radioguidance with a portable gamma camera during laparoscopic sentinel node (SN) procedures in urological malignancies. We evaluated the use of the intraoperative portable gamma camera in 20 patients: 16 patients with prostate carcinoma (PCC), 2 patients with renal cell carcinoma (RC) and 2 patients with testicular cancer (TC). Intra/peritumoural injection of {sup 99m}Tc-nanocolloid ({sup 99m}Tc) was followed by planar lymphoscintigraphy, SPECT/CT and marking of SN levels. Before laparoscopy a {sup 125}I seed was fixed on the laparoscopic gamma probe as a pointer of SN seeking. The portable gamma camera was set to display the {sup 99m}Tc signal for SN localisation and the {sup 125}I signal for SN seeking. Matching of these signals on screen indicated exact SN localisation, and consequently this SN was removed. The mean injected dose was 218 MBq in PCC, 228 MBq in RC and 88 MBq in TC. Pelvic SN were visualised in all PCC patients, with uncommonly located SN in seven patients. SN metastases were found in seven patients (one in a uncommonly located SN). Both RC patients and TC patients had para-aortic SN, which were all tumour free. A total of 59 SN were removed. The portable gamma camera enabled real-time SN display/identification in 18 patients (90%). The use of a portable gamma camera in combination with a laparoscopic gamma probe incorporates intraoperative real-time imaging with improved SN identification in urological malignancies. This procedure might also be useful for SN identification of other deep draining malignancies. (orig.)

  7. Quality assurance of gamma cameras and PET scanners - Implementation of the Euratom Directive in Austria

    International Nuclear Information System (INIS)

    Aim: Council Directive 97/43/Euratom on health protection of individuals against the dangers of ionizing radiation in relation to medical exposure requests acceptance testing (carried out before the first use of the equipment for clinical purposes), and thereafter performance testing on a regular basis and after any major maintenance work. This directive has been put into national legislation by a governmental regulation in July 2001. Materials and Methods: A task force of the Austrian Societies of Nuclear Medicine and Medical Physics developed a comprehensive set of recommendations to serve as a guideline for correct implementation of the directive. Regular performance testing for planar and SPECT-cameras is carried out according to existing national standards. As no guidelines for regular performance testing were available for gamma camera PET (GCPET) and dedicated PET (DPET) systems by now, suitable procedures were defined by the task force to enable testing of important performance parameters of those systems. Wherever possible, the newly developed procedures were based on NEMA standard procedures and manufacturer's recommendations. For some performance parameters modified tests were developed which were adapted to the needs of frequently used routine tests. Results: Performance testing for SPECT-cameras includes inspection of planar properties as well as regular verification of center of rotation, inhomogeneity, spatial resolution, and contrast of reconstructed images. For gamma cameras with coincidence imaging capabilities, uniformity in coincidence mode, energy resolution, and sensitivity of coincidence imaging are inspected as well. Dedicated PET scanners require a daily check of detector sensitivity and a calibration scan for the attenuation correction mechanisms. Some of those systems require further calibration procedures such as update of amplifier gain or coincidence timing. For quantitative measurements a quarterly performance test of tomographic

  8. Integration of gamma cameras and PET devices of multiple vendors in several locations

    International Nuclear Information System (INIS)

    Full text: The Department of Nuclear Medicine of the University of Munich consists of four independently operated locations with a total of 18 gamma cameras (of three vendors), one PET scanner and one coincidence gamma camera. Recent hardware improvements, the installation and development of fast networks and new technologies for storage of large data volumes all contribute to the propagation of digital reading and reporting of nuclear medicine studies. Thus, the vision of a fully digitized nuclear medicine department becomes reality. In 1997 the department started with a strategy to fully integrate the entire number of imaging devices into one network for filmless reading, archiving and distributing nuclear medicine studies throughout the hospitals. The decision was made to use HERMES workstations (Nuclear Diagnostics, Sweden) to connect all primary imaging modalities. The purpose of the workstations located in the Nuclear Medicine departments is threefold: postprocessing, reading and archiving of all data. The workstations are networked throughout the different hospitals and are able to read the proprietary or DICOM data of the vendors of the gamma camera and PET equipment. The HERMES system is connected via DICOM interface to a long term storage device (AGFA, Germany). Additionally a JAVA (SUN Microsystems, USA) based software (JARVIS, Nuclear Diagnostics) is available to view all data from any computer using a web browser. Furthermore all data is linked to the hospital information system and selected imaging data are distributed throughout the hospitals. After commencement of full service of the network in 2000 the department is over 95 % filmfree. The high costs of purchasing hardware- and software-components are compensated for by saving costs of films and by the improvement of the work flow. Independently from these issues, filmless reporting proves to be advantageous over conventional film reading in many facts that justify to switch to a digital department

  9. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    Science.gov (United States)

    Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

    2014-05-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  10. Visualization of exceeding threshold parameters in the gamma camera for quality assurance

    International Nuclear Information System (INIS)

    The quality of gamma cameras should be checked regularly according to the guidelines of OENORM S 5271 in order to detect deviance of the machines. Whereas for some of the measured parameters threshold limits exist, there are only few images for visualisation of the loss in image quality available. The quality control in Nuclear Medicine is important because small artefacts can play an important roll in diagnostics. It is therefore necessary to get an idea of how pictures with bad quality parameters look like. The intensive deal with software parameters, like the linearity, the energy or the sensitivity correction is done according to machine requirements. Therefore it is necessary to be informed about the maximum in deviation, which can occurs in between. (authors)

  11. Measurement of spleen size using gamma camera scintigraphy in essential thrombocythaemia

    Energy Technology Data Exchange (ETDEWEB)

    Revesz, P. (Department of Medicine, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden)); Carneskog, J.; Wadenvik, H.; Kutti, J. (Haematology Section, Department of Medicine, Sahlgrenska Hospital, University of Goeteborg, Goeteborg (Sweden)); Jarneborn, L. (Department of Clinical Physiology, Oestra Hospital, University of Goeteborg, Goeteborg (Sweden))

    1993-09-01

    By using gamma camera imaging the spleen size was determined in 33 consecutive patients with essential thrombocythaemia (ET) and in 33 consecutive patients with reactive thrombocytosis (RT). All ET patients were newly diagnosed and had not received myelosuppressive treatment prior to study; they all fulfilled the criteria for ET as established by the Polycythemia Vera Study Group. In both posterior and lateral projections, the spleen area in the group of ET patients was significantly larger than in the RT patients. The present study has shown that 39% of ET patients at diagnosis have splenic enlargement. Evaluation of Spleen size is therefore a useful diagnostic test in patients presenting with unexplained thrombocytosis. (au) (15 refs.).

  12. First results on SPI/INTEGRAL flight-model gamma-camera calibration

    International Nuclear Information System (INIS)

    SPI is a high resolution γ-ray telescope that will fly onboard the INTEGRAL observatory in 2002. The telescope uses cooled germanium detectors and operates over the energy range 20 keV to 8 MeV with an energy resolution of 1-5 keV (2 keV at 1 MeV). A tungsten coded mask located 1.7 m above the detector array provides imaging capabilities over a 15 deg. fully coded field of view with an angular resolution of ∼3 deg. . From calibrations of the gamma camera, we have measured various parameters such as the energy resolution, detection efficiency of the 19 individual Germanium detectors of the detector array. Furthermore, these calibrations allow us to check the homogeneity of the detector array

  13. Single-acquisition method for simultaneous determination of extrinsic gamma-camera sensitivity and spatial resolution

    International Nuclear Information System (INIS)

    A new method for measuring simultaneously both the extrinsic sensitivity and spatial resolution of a gamma-camera in a single planar acquisition was implemented. A dual-purpose phantom (SR phantom; sensitivity/resolution) was developed, tested and the results compared with other conventional methods used for separate determination of these two important image quality parameters. The SR phantom yielded reproducible and accurate results, allowing an immediate visual inspection of the spatial resolution as well as the quantitative determination of the contrast for six different spatial frequencies. It also proved to be useful in the estimation of the modulation transfer function (MTF) of the image formation collimator/detector system at six different frequencies and can be used to estimate the spatial resolution as function of the direction relative to the digital matrix of the detector

  14. Renal scintiscanning: Methodology and normal findings using 131I hippurane and a gamma camera

    International Nuclear Information System (INIS)

    The methodological and mathematical fundamentals of renal functional scintiscanning using a gamma camera and 131I-hippurane are described for ING, whole-body clearance, plasma clearance, and unilateral clearance. Methods are compared introducing the Tuebingen method of unilateral clearance with tolerance limits. The data of the patients are presented as standard values with a limit of two standard deviations for whole-body clearance unilateral clearance, the parenchymal phase and the excretion phase including a percentage of excretion. Comparative studies are presented for the main parameters of clearance and unilateral clearance, and the data obtained are documented in tables and graphs together with the initial data and the standard values. The results and problems of the method are gone into. (orig./MG)

  15. Evaluation of intrinsic uniformity of gamma cameras in two hospitals in the Costa Rican Social Security

    International Nuclear Information System (INIS)

    It is well known that in diagnostic imaging, quality control procedures are important to verify the correct performance of the equipment under certain irradiation conditions that do not vary over time. At the Caja Costarricense del Seguro Social, in the past few years medical physicists have been incorporated in order to verify and carry on quality control tests in the instruments of the nuclear medicine departments. One of the first tasks was to develop a digital management system of data resulting from quality control tests. The aim of this work is to present the results of the analysis of approximately five years of cumulated data from gamma camera intrinsic uniformity evaluation at the San Juan de Dios Hospital, and almost two years at the Mexico Hospital

  16. Verification test for developing decontamination plan using panorama measurement with Gamma Camera

    International Nuclear Information System (INIS)

    Panorama measurement with Gamma Camera has been developed to support efficient decontamination of radioactive material spread by the accident of Fukushima Daiichi Nuclear Power Plant. The decontamination plan using Panorama Measurement will provide efficient decontamination. In order to confirm its usability, verification test has been performed. Panorama Measurement was performed before decontamination and extracted areas which have a huge effect on air dose rate. 'Selected decontamination' which decontaminates only extracted areas with less man-hour showed almost same effect of decreasing of air dose rate as 'Whole area decontamination'. It was confirmed that decontamination plan using Panorama Measurement was use full for efficient decontamination. (author)

  17. First experience DaTSCAN imaging using cadmium-zinc-telluride gamma camera SPECT.

    Science.gov (United States)

    Farid, Karim; Queneau, Mathieu; Guernou, Mohamed; Lussato, David; Poullias, Xavier; Petras, Slavomir; Caillat-Vigneron, Nadine; Songy, Bernard

    2012-08-01

    We report our first experience of brain DaTSCAN SPECT imaging using cadmium-zinc-telluride gamma camera (CZT-GC) in 2 cases: a 64-year-old patient suffering from essential tremor and a 73-year-old patient presenting with atypical bilateral extrapyramidal syndrome. In both cases, 2 different acquisitions were performed and compared, using a double-head Anger-GC, followed immediately by a second acquisition on CZT-GC. There were no significant visual differences between images generated by different GC. Our first result suggests that DaTSCAN SPECT is feasible on CZT-GC, allowing both injected dose and acquisition time reductions without compromising image quality. This experience needs to be evaluated in larger series. PMID:22785531

  18. A new approach to the evaluation of peripheral vascular disease using the gamma camera

    International Nuclear Information System (INIS)

    To estimate the degree of impaired perfusion in legs, and the extent of improvement after treatment, a functional test was developed using a gamma camera to follow the perfusion of intravenously injected sup(99m)Tc-pertechnetate. An analysis is given of normal and pathologic curve patterns. The influence of the severity of occlusive arterial disease on the arrival and distribution of radioactivity in the leg is demonstrated. After vascular surgery, changes in the curve pattern and the imaging of activity distribution reflected the function of the inserted bypass grafts. The test proved to be useful in the differentiation between patients with false claudication complaints due to non-arterial disease and patients with true claudication. It is concluded that the technique presented in this thesis can serve as a useful, non-invasive, screening test prior to arteriography and as a functional assessment of vascular reconstruction

  19. Maximum-likelihood scintillation detection for EM-CCD based gamma cameras

    International Nuclear Information System (INIS)

    Gamma cameras based on charge-coupled devices (CCDs) coupled to continuous scintillation crystals can combine a good detection efficiency with high spatial resolutions with the aid of advanced scintillation detection algorithms. A previously developed analytical multi-scale algorithm (MSA) models the depth-dependent light distribution but does not take statistics into account. Here we present and validate a novel statistical maximum-likelihood algorithm (MLA) that combines a realistic light distribution model with an experimentally validated statistical model. The MLA was tested for an electron multiplying CCD optically coupled to CsI(Tl) scintillators of different thicknesses. For 99mTc imaging, the spatial resolution (for perpendicular and oblique incidence), energy resolution and signal-to-background counts ratio (SBR) obtained with the MLA were compared with those of the MSA. Compared to the MSA, the MLA improves the energy resolution by more than a factor of 1.6 and the SBR is enhanced by more than a factor of 1.3. For oblique incidence (approximately 450), the depth-of-interaction corrected spatial resolution is improved by a factor of at least 1.1, while for perpendicular incidence the MLA resolution does not consistently differ significantly from the MSA result for all tested scintillator thicknesses. For the thickest scintillator (3 mm, interaction probability 66% at 141 keV) a spatial resolution (perpendicular incidence) of 147 μm full width at half maximum (FWHM) was obtained with an energy resolution of 35.2% FWHM. These results of the MLA were achieved without prior calibration of scintillations as is needed for many statistical scintillation detection algorithms. We conclude that the MLA significantly improves the gamma camera performance compared to the MSA.

  20. Quantitative imaging and dosimetry of radiolabelled monoclonal antibodies: Gamma camera quality assurance requirements

    International Nuclear Information System (INIS)

    Full text: The clinical evaluation of tumour targeting monoclonal antibodies requires accurate dosimetry of radiolabelled antibody distribution in normal tissues as well as in tumour, and is usually performed with gamma camera imaging. This allows the biodistribution of the antibody to be determined, and the use of SPECT also permits a more accurate evaluation of the spatial localisation of antibody in tumour and normal tissue to be made. The purpose of this study was to develop quantitative techniques for imaging radio-labelled monoclonal antibodies in vivo. Studies were performed on a dual-head Biad gamma camera (Trionix, Twinsberg, Ohio) linked to a dedicated Sun work station. Quality assurance testing was performed with 131I sources, and high energy collimators, as required for clinical studies. Uniformity correction was performed with an 131I flood source, resulting in mean pre-correction and post-correction values (mean both heads) for central FOV of 12.5% and 2.12% (integral error) and 7.95% and 1.56% (differential error), respectively. Spatial resolution as evaluated with SPECT image acquisitions of line sources of 131I in air and water-filled phantoms. With a 23.5 cm radius of rotation (ROR) SPECT acquisition and an 131I line source on-axis and in air the radial FWHM was 19.58 + 0.11 mm and tangential FWHM 20.09 + 0.39 mm, and in water 19.54 + 0.03 mm and 19.32 + 0.04 mm, respectively. Lesion detectability and quantitation was also evaluated with a Jaszczak phantom containing spheres ranging from 12.7-38.1 mm in size and varying 131I activity concentrations. These preclinical studies will allow accurate dosimetry to be performed in forthcoming clinical trials of radiolabelled monoclonal antibodies in cancer patients

  1. FDG scan on an ordinary coincidence gamma camera (CDET) -preliminary data in pulmonary or colorectal cancer

    International Nuclear Information System (INIS)

    Full text. The purpose of this study to evaluate the impact of FDG scan performed on an ordinary CDET gamma camera on the therapeutic management of patients with pulmonary nodules or with suspicion of recurrent colorectal carcinoma. Methods: two tomoscintigrams (thorax and abdomen) were acquired, using a PICKER Prism XP 2000 coincidence gamma camera, 45 m after i.v. injection of 100-150 MBq of 18 F-FDG in fasting patients. The 21 pts were explored in July or August 1997. Preliminary results: among 12 patients with pulmonary nodules, the planed surgery was replaced by chemotherapy after visualization of unknown metastases accumulating FDG in 3 patients. In another one, the high uptake of FDG by a lung nodule which has been known for 6 years, led to surgery and objectivation of an adenocarcinoma. In one case, the absence of FDG uptake corresponded to an abscess (true negative result). In the other 7 patients, the indication of surgery was confirmed but the procedure was modified in 2 cases. In case of suspicion of recurrent colorectal carcinoma (9 patients), the finding of a single focus of FDG uptake whereas CT scan was negative or inconclusive let do the decision of surgery in 3 patients. In one patient with pelvic pain without increase of tumor markers levels and with normal CT scan, a normal FDG scan confirmed the physician's hypothesis of pain due to the previous therapy but do not recurrence. In one patient, the finding of 3 foci of uptake of FDG whereas CT scan was inconclusive confirmed the indication of chemotherapy. In 2 patients with FDG abdominal foci without morphologic abnormalities, the therapeutic strategy is not yet decided in 2 patients, no foci could be found. In conclusion, these preliminary results show that FDG scan has provided a help to the physician indecision-making for therapeutic strategy in 8 patients on 21 (38%) and a help to the surgeon in 2 more cases (48% as a whole)

  2. Monte Carlo simulation of breast tumor imaging properties with compact, discrete gamma cameras

    International Nuclear Information System (INIS)

    The authors describe Monte Carlo simulation results for breast tumor imaging using a compact, discrete gamma camera. The simulations were designed to analyze and optimize camera design, particularly collimator configuration and detector pixel size. Simulated planar images of 5--15 mm diameter tumors in a phantom patient (including a breast, torso, and heart) were generated for imaging distances of 5--55 mm, pixel sizes of 2 x 2--4 x 4 mm2, and hexagonal and square hole collimators with sensitivities from 4,000 to 16,000 counts/mCi/sec. Other factors considered included T/B (tumor-to-background tissue uptake ratio) and detector energy resolution. Image properties were quantified by computing the observed tumor fwhm (full-width at half-maximum) and S/N (sum of detected tumor events divided by the statistical noise). Results suggest that hexagonal and square hole collimators perform comparably, that higher sensitivity collimators provide higher tumor S/N with little increase in the observed tumor fwhm, that smaller pixels only slightly improve tumor fwhm and S/N, and that improved detector energy resolution has little impact on either the observed tumor fwhm or the observed tumor S/N

  3. Heart imaging by cadmium telluride gamma camera European Program 'BIOMED' consortium

    CERN Document Server

    Scheiber, C; Chambron, J; Prat, V; Kazandjan, A; Jahnke, A; Matz, R; Thomas, S; Warren, S; Hage-Hali, M; Regal, R; Siffert, P; Karman, M

    1999-01-01

    Cadmium telluride semiconductor detectors (CdTe) operating at room temperature are attractive for medical imaging because of their good energy resolution providing excellent spatial and contrast resolution. The compactness of the detection system allows the building of small light camera heads which can be used for bedside imaging. A mobile pixellated gamma camera based on 2304 CdTe (pixel size: 3x3 mm, field of view: 15 cmx15 cm) has been designed for cardiac imaging. A dedicated 16-channel integrated circuit has also been designed. The acquisition hardware is fully programmable (DSP card, personal computer-based system). Analytical calculations have shown that a commercial parallel hole collimator will fit the efficiency/resolution requirements for cardiac applications. Monte-Carlo simulations predict that the Moire effect can be reduced by a 15 deg. tilt of the collimator with respect to the detector grid. A 16x16 CdTe module has been built for the preliminary physical tests. The energy resolution was 6.16...

  4. The X-/Gamma-ray camera ECLAIRs for the Gammay-ray burst mission SVOM

    CERN Document Server

    Godet, O; Atteia, J -L; Cordier, B; Mandrou, P; Barret, D; Triou, H; Pons, R; Amoros, C; Bordon, S; Gevin, O; Gonzalez, F; Götz, D; Gros, A; Houret, B; Lachaud, C; Lacombe, K; Marty, W; Mercier, K; Rambaud, D; Ramon, P; Rouaix, G; Schanne, S; Waegebaert, V

    2014-01-01

    We present ECLAIRs, the Gamma-ray burst (GRB) trigger camera to fly on-board the Chinese-French mission SVOM. ECLAIRs is a wide-field ($\\sim 2$\\,sr) coded mask camera with a mask transparency of 40\\% and a 1024 $\\mathrm{cm}^2$ detection plane coupled to a data processing unit, so-called UGTS, which is in charge of locating GRBs in near real time thanks to image and rate triggers. We present the instrument science requirements and how the design of ECLAIRs has been optimized to increase its sensitivity to high-redshift GRBs and low-luminosity GRBs in the local Universe, by having a low-energy threshold of 4 keV. The total spectral coverage ranges from 4 to 150 keV. ECLAIRs is expected to detect $\\sim 200$ GRBs of all types during the nominal 3 year mission lifetime. To reach a 4 keV low-energy threshold, the ECLAIRs detection plane is paved with 6400 $4\\times 4~\\mathrm{mm}^2$ and 1 mm-thick Schottky CdTe detectors. The detectors are grouped by 32, in 8x4 matrices read by a low-noise ASIC, forming elementary mo...

  5. Methodology for Gamma cameras calibration for I-131 uptake quantification in Hyperthyroidism diseases

    International Nuclear Information System (INIS)

    Optimization and verification of Patient-Specific Treatment Planning with unsealed I-131 sources is a desirable goal from medical and radiation protection point of view. To obtain a practical protocol to combine the estimation of the related parameters with patient's specific treatment dose in hyperthyroidism disease, 3 equipment were studied (Iodine Probe, a Philips Forte Camera with pin-hole collimators and a Mediso Nucline with HEGP for planar and SPECT techniques) and crossed calibrated. The linear behaviour on diagnostic and therapeutic activity range was verified, showing a linear correlation fitting factor R2 > 0.99. The differences between thyroid uptake determinations in all equipment were less than 6% for therapeutic activities and less than 1.1% in the diagnostic range. The combined protocol to calculate, with only one administration of I131, all the necessary parameters to the treatment dose estimation in 2D or 3D, avoiding wasting time with gamma cameras, was established and verified. Following this protocol the difference between apparent and calculated activities were less than 3%. (Author)

  6. Gamma camera based Positron Emission Tomography: a study of the viability on quantification

    International Nuclear Information System (INIS)

    Positron Emission Tomography (PET) is a Nuclear Medicine imaging modality for diagnostic purposes. Pharmaceuticals labeled with positron emitters are used and images which represent the in vivo biochemical process within tissues can be obtained. The positron/electron annihilation photons are detected in coincidence and this information is used for object reconstruction. Presently, there are two types of systems available for this imaging modality: the dedicated systems and those based on gamma camera technology. In this work, we utilized PET/SPECT systems, which also allows for the traditional Nuclear Medicine studies based on single photon emitters. There are inherent difficulties which affect quantification of activity and other indices. They are related to the Poisson nature of radioactivity, to radiation interactions with patient body and detector, noise due to statistical nature of these interactions and to all the detection processes, as well as the patient acquisition protocols. Corrections are described in the literature and not all of them are implemented by the manufacturers: scatter, attenuation, random, decay, dead time, spatial resolution, and others related to the properties of each equipment. The goal of this work was to assess these methods adopted by two manufacturers, as well as the influence of some technical characteristics of PET/SPECT systems on the estimation of SUV. Data from a set of phantoms were collected in 3D mode by one camera and 2D, by the other. We concluded that quantification is viable in PET/SPECT systems, including the estimation of SUVs. This is only possible if, apart from the above mentioned corrections, the camera is well tuned and coefficients for sensitivity normalization and partial volume corrections are applied. We also verified that the shapes of the sources used for obtaining these factors play a role on the final results and should be delt with carefully in clinical quantification. Finally, the choice of the region

  7. Statistical pixelwise inference models for planar data analysis: an application to gamma-camera uniformity monitoring

    International Nuclear Information System (INIS)

    In this paper two tests based on statistical models are presented and used to assess, quantify and provide positional information of the existence of bias and/or variations between planar images acquired at different times but under similar conditions. In the first test a linear regression model is fitted to the data in a pixelwise fashion, using three mathematical operators. In the second test a comparison using z-scoring is used based on the assumption that Poisson statistics are valid. For both tests the underlying assumptions are as simple and few as possible. The results are presented as parametric maps of either the three operators or the z-score. The z-score maps can then be thresholded to show the parts of the images which demonstrate change. Three different thresholding methods (naive, adaptive and multiple) are presented: together they cover almost all the needs for separating the signal from the background in the z-score maps. Where the expected size of the signal is known or can be estimated, a spatial correction technique (referred to as the reef correction) can be applied. These tests were applied to flood images used for the quality control of gamma camera uniformity. Simulated data were used to check the validity of the methods. Real data were acquired from four different cameras from two different institutions using a variety of acquisition parameters. The regression model found the bias in all five simulated cases and it also found patterns of unstable regions in real data where visual inspection of the flood images did not show any problems. In comparison the z-map revealed the differences in the simulated images from as low as 1.8 standard deviations from the mean, corresponding to a differential uniformity of 2.2% over the central field of view. In all cases studied, the reef correction increased significantly the sensitivity of the method and in most cases the specificity as well. The two proposed tests can be used either separately or in

  8. Statistical pixelwise inference models for planar data analysis: an application to gamma-camera uniformity monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kalemis, A [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Bailey, D L [Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW 2065 (Australia); Flower, M A [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Lord, S K [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom); Ott, R J [Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom)

    2004-07-21

    In this paper two tests based on statistical models are presented and used to assess, quantify and provide positional information of the existence of bias and/or variations between planar images acquired at different times but under similar conditions. In the first test a linear regression model is fitted to the data in a pixelwise fashion, using three mathematical operators. In the second test a comparison using z-scoring is used based on the assumption that Poisson statistics are valid. For both tests the underlying assumptions are as simple and few as possible. The results are presented as parametric maps of either the three operators or the z-score. The z-score maps can then be thresholded to show the parts of the images which demonstrate change. Three different thresholding methods (naive, adaptive and multiple) are presented: together they cover almost all the needs for separating the signal from the background in the z-score maps. Where the expected size of the signal is known or can be estimated, a spatial correction technique (referred to as the reef correction) can be applied. These tests were applied to flood images used for the quality control of gamma camera uniformity. Simulated data were used to check the validity of the methods. Real data were acquired from four different cameras from two different institutions using a variety of acquisition parameters. The regression model found the bias in all five simulated cases and it also found patterns of unstable regions in real data where visual inspection of the flood images did not show any problems. In comparison the z-map revealed the differences in the simulated images from as low as 1.8 standard deviations from the mean, corresponding to a differential uniformity of 2.2% over the central field of view. In all cases studied, the reef correction increased significantly the sensitivity of the method and in most cases the specificity as well. The two proposed tests can be used either separately or in

  9. Small Field of View Scintimammography Gamma Camera Integrated to a Stereotactic Core Biopsy Digital X-ray System

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Weisenberger; Fernando Barbosa; T. D. Green; R. Hoefer; Cynthia Keppel; Brian Kross; Stanislaw Majewski; Vladimir Popov; Randolph Wojcik

    2002-10-01

    A small field of view gamma camera has been developed for integration with a commercial stereotactic core biopsy system. The goal is to develop and implement a dual-modality imaging system utilizing scintimammography and digital radiography to evaluate the reliability of scintimammography in predicting the malignancy of suspected breast lesions from conventional X-ray mammography. The scintimammography gamma camera is a custom-built mini gamma camera with an active area of 5.3 cm /spl times/ 5.3 cm and is based on a 2 /spl times/ 2 array of Hamamatsu R7600-C8 position-sensitive photomultiplier tubes. The spatial resolution of the gamma camera at the collimator surface is < 4 mm full-width at half-maximum and a sensitivity of /spl sim/ 4000 Hz/mCi. The system is also capable of acquiring dynamic scintimammographic data to allow for dynamic uptake studies. Sample images of preliminary clinical results are presented to demonstrate the performance of the system.

  10. LaBr3:Ce small FOV gamma camera with excellent energy resolution for multi-isotope imaging

    International Nuclear Information System (INIS)

    The simultaneous administration of radiopharmaceuticals labeled with more than one radioisotope is becoming of increasing interest in clinical practice. Because the photon energies of the utilized radioisotopes could be very close (less than 15% difference), a gamma camera with adequate energy resolution is required. The availability of scintillation crystals with high light yield, as lanthanum tri-bromide (LaBr3:Ce), is particularly appealing for these applications. In this work, a new small field of view gamma camera prototype is presented, based on a planar LaBr3:Ce scintillation crystal with surfaces treatment typical of spectrometric devices, in order to enhance energy resolution performances. The crystal has round shape and has been optically coupled with a position sensitive photomultiplier tube with high quantum efficiency. The presented gamma camera shows outstanding energy resolution results in the investigated energy range (32–662 keV). These relevant performances have been obtained through the application of uniformity correction on the raw data, necessary due to the presence of position sensitive phototube, characterized by a spread of anodic gain values. In spite of position linearity degradation at crystal edges, due to reflective treatment of surfaces, intrinsic spatial resolution values are satisfactory on the useful field of view.The characterization of the presented gamma camera, based on a continuous LaBr3:Ce scintillation crystal with reflective surfaces, indicates good performances in multi-isotope imaging due to the excellent energy resolution results, also in comparison with similar detectors

  11. Realization and study of spectral properties of the ISGRI gamma-ray camera

    International Nuclear Information System (INIS)

    This work evaluates spectroscopic and physical properties of CdTe detectors in view of assembling a large number on a new generation spectro-imager for space gamma-ray astronomy. Study, optimization, realization and calibration of modular detection units of the ISGRI camera are described. After a description of the experimental context of the INTEGRAL program and a review of the physical processes involved in gamma-ray photon detectors, we present an analysis of the properties of CdTe detectors attempting to be so exhaustive as possible. We propose the base point of a global model, which relates charge transport properties, spectral response and possible instabilities in the detectors. We propose a new formulation of the Hecht relation that describes charge loss as a function of the detector charge transport properties. We discuss at length the method of charge loss correction and its consequences on the associated integrated electronics definition. Finally, we illustrate our instrument capabilities using as an example the observation of titanium 44 lines in historical supernovae. (author)

  12. Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

    Energy Technology Data Exchange (ETDEWEB)

    Russo, Paolo; Curion, Assunta S.; Mettivier, Giovanni; Esposito, Michela; Aurilio, Michela; Caraco, Corradina; Aloj, Luigi; Lastoria, Secondo [Dipartimento di Scienze Fisiche, Universita di Napoli Federico II, I-80126 Napoli (Italy) and Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, I-80126 Napoli (Italy); Medicina Nucleare, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, I-80131 Napoli (Italy)

    2011-03-15

    Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. Methods: The room-temperature CdTe pixel detector (1 mm thick) has 256x256 square pixels arranged with a 55 {mu}m pitch (sensitive area 14.08x14.08 mm{sup 2}), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diameter at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. Results: For {sup 99m}Tc, at 50 mm distance, a background-subtracted sensitivity of 6.5x10{sup -3} cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3x10{sup -2} cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq {sup 99m}Tc and prior localization with standard gamma camera lymphoscintigraphy. Conclusions: The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter

  13. Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

    International Nuclear Information System (INIS)

    Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. Methods: The room-temperature CdTe pixel detector (1 mm thick) has 256x256 square pixels arranged with a 55 μm pitch (sensitive area 14.08x14.08 mm2), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diameter at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. Results: For 99mTc, at 50 mm distance, a background-subtracted sensitivity of 6.5x10-3 cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3x10-2 cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq 99mTc and prior localization with standard gamma camera lymphoscintigraphy. Conclusions: The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at shorter distances from the patient skin.

  14. Lymphoscintigraphic imaging study for quantitative evaluation of a small field of view (SFOV) gamma camera

    International Nuclear Information System (INIS)

    The Hybrid Compact Gamma Camera (HCGC) is a portable optical-gamma hybrid imager designed for intraoperative medical imaging, particularly for sentinel lymph node biopsy procedures. To investigate the capability of the HCGC in lymphatic system imaging, two lymphoscintigraphic phantoms have been designed and constructed. These phantoms allowed quantitative assessment and evaluation of the HCGC for lymphatic vessel (LV) and sentinel lymph node (SLN) detection. Fused optical and gamma images showed good alignment of the two modalities allowing localisation of activity within the LV and the SLN. At an imaging distance of 10 cm, the spatial resolution of the HCGC during the detection process of the simulated LV was not degraded at a separation of more than 1.5 cm (variation <5%) from the injection site (IS). Even in the presence of the IS the targeted LV was detectable with an acquisition time of less than 2 minutes. The HCGC could detect SLNs containing different radioactivity concentrations (ranging between 1:20 to 1:100 SLN to IS activity ratios) and under various scattering thicknesses (ranging between 5 mm to 30 mm) with high contrast-to-noise ratio (CNR) values (ranging between 11.6 and 110.8). The HCGC can detect the simulated SLNs at various IS to SLN distances, different IS to SLN activity ratios and through varied scattering medium thicknesses. The HCGC provided an accurate physical localisation of radiopharmaceutical uptake in the simulated SLN. These characteristics of the HCGC reflect its suitability for utilisation in lymphatic vessel drainage imaging and SLN imaging in patients in different critical clinical situations such as interventional and surgical procedures

  15. Lymphoscintigraphic imaging study for quantitative evaluation of a small field of view (SFOV) gamma camera

    Science.gov (United States)

    Alqahtani, M. S.; Lees, J. E.; Bugby, S. L.; Jambi, L. K.; Perkins, A. C.

    2015-07-01

    The Hybrid Compact Gamma Camera (HCGC) is a portable optical-gamma hybrid imager designed for intraoperative medical imaging, particularly for sentinel lymph node biopsy procedures. To investigate the capability of the HCGC in lymphatic system imaging, two lymphoscintigraphic phantoms have been designed and constructed. These phantoms allowed quantitative assessment and evaluation of the HCGC for lymphatic vessel (LV) and sentinel lymph node (SLN) detection. Fused optical and gamma images showed good alignment of the two modalities allowing localisation of activity within the LV and the SLN. At an imaging distance of 10 cm, the spatial resolution of the HCGC during the detection process of the simulated LV was not degraded at a separation of more than 1.5 cm (variation <5%) from the injection site (IS). Even in the presence of the IS the targeted LV was detectable with an acquisition time of less than 2 minutes. The HCGC could detect SLNs containing different radioactivity concentrations (ranging between 1:20 to 1:100 SLN to IS activity ratios) and under various scattering thicknesses (ranging between 5 mm to 30 mm) with high contrast-to-noise ratio (CNR) values (ranging between 11.6 and 110.8). The HCGC can detect the simulated SLNs at various IS to SLN distances, different IS to SLN activity ratios and through varied scattering medium thicknesses. The HCGC provided an accurate physical localisation of radiopharmaceutical uptake in the simulated SLN. These characteristics of the HCGC reflect its suitability for utilisation in lymphatic vessel drainage imaging and SLN imaging in patients in different critical clinical situations such as interventional and surgical procedures.

  16. A performance study of an electron-tracking Compton camera with a compact system for environmental gamma-ray observation

    CERN Document Server

    Mizumoto, Tetsuya; Takada, Atsushi; Tanimori, Toru; Komura, Shotaro; Kubo, Hidetoshi; Matsuoka, Yoshihiro; Mizumura, Yoshitaka; Nakamura, Kiseki; Nakamura, Shogo; Oda, Makoto; Parker, Joseph D; Sawano, Tatsuya; Bando, Naoto; Nabetani, Akira

    2015-01-01

    An electron-tracking Compton camera (ETCC) is a detector that can determine the arrival direction and energy of incident sub-MeV/MeV gamma-ray events on an event-by-event basis. It is a hybrid detector consisting of a gaseous time projection chamber (TPC), that is the Compton-scattering target and the tracker of recoil electrons, and a position-sensitive scintillation camera that absorbs of the scattered gamma rays, to measure gamma rays in the environment from contaminated soil. To measure of environmental gamma rays from soil contaminated with radioactive cesium (Cs), we developed a portable battery-powered ETCC system with a compact readout circuit and data-acquisition system for the SMILE-II experiment. We checked the gamma-ray imaging ability and ETCC performance in the laboratory by using several gamma-ray point sources. The performance test indicates that the field of view (FoV) of the detector is about 1$\\;$sr and that the detection efficiency and angular resolution for 662$\\;$keV gamma rays from the ...

  17. FACT-The first Cherenkov telescope using a G-APD camera for TeV gamma-ray astronomy

    International Nuclear Information System (INIS)

    Geiger-mode Avalanche Photodiodes (G-APD) bear the potential to significantly improve the sensitivity of Imaging Air Cherenkov Telescopes (IACT). We are currently building the First G-APD Cherenkov Telescope (FACT) by refurbishing an old IACT with a mirror area of 9.5 square meters and are constructing a new, fine-pixelized camera using novel G-APDs. The main goal is to evaluate the performance of a complete system by observing very high energy gamma-rays from the Crab Nebula. This is an important field test to check the feasibility of G-APD-based cameras to replace at some time the PMT-based cameras of planned future IACTs like AGIS and CTA. In this article, we present the basic design of such a camera as well as some important details.

  18. News in nuclear cardiology: A gamma camera with semiconductors dedicated to cardiac imaging;Nouveautes en cardiologie nucleaire: une gamma camera a semi-conducteurs dediee a l'imagerie cardiaque

    Energy Technology Data Exchange (ETDEWEB)

    Godbert, Y.; Bullier, E.; Riviere, A.L.; Laffon, E.; Guyot, M.; Bordenave, L.; Barat, J.L. [CHU de Bordeaux, Service de medecine nucleaire, hopital du Haut-Leveque, 33 - Pessac (France)

    2010-03-15

    During the last few years, cardiac imaging made important breakthroughs thanks to the development of various techniques allowing the risk stratification of patients with coronary artery disease. The well-established single photon emission computed tomography (SPECT) as a myocardial imaging technique made an important progress with the recent improvement of high-speed volume acquisition, using dedicated semi-conductor gamma camera. These cameras bring significant improvement to the image quality and the image acquisition time, which is now seven times lower. New type of artefacts is expected because of the geometry of detection, thus studies are still needed to assess the exact performance of this revolutionary technology. (authors)

  19. Radioisotope guided surgery with imaging probe, a hand-held high-resolution gamma camera

    International Nuclear Information System (INIS)

    Since 1997, our group of Physics together with Nuclear Physicians studies imaging probes (IP), hand-held, high-resolution gamma cameras for radio-guided surgery (RGS). Present work is aimed to verify the usefulness of two updated IP in different surgical operations. Forty patients scheduled for breast cancer sentinel node (SN) biopsy, five patients with nodal recurrence of thyroid cancer, seven patients with parathyroid adenomas, five patients with neuroendocrine tumours (NET), were operated under the guide of IP. We used two different IP with field of view of 1 and 4 in.2, respectively and intrinsic spatial resolution of about 2 mm. Radioisotopes were 99mTc, 123I and 111In. The 1 in.2 IP detected SN in all the 40 patients and more than one node in 24, whereas anger camera (AC) failed locating SN in four patients and detected true positive second nodes in only nine patients. The 4 in.2 IP was used for RGS of thyroid, parathyroid and NETs. It detected eight latero-cervical nodes. In the same patients, AC detected five invaded nodes. Parathyroid adenomas detected by IP were 10 in 7 patients, NET five in five patients. One and 4 in.2 IPs showed usefulness in all operations. Initial studies on SN biopsy were carried out on small series of patients to validate IP and to demonstrate the effectiveness and usefulness of IP alone or against conventional probes. We propose the use of the IP as control method for legal documentation and surgeon strategy guide before and after lesion(s) removal

  20. Imaging of radiocesium uptake dynamics in a plant body using a newly developed high-resolution gamma camera for radiocesium

    Energy Technology Data Exchange (ETDEWEB)

    Kawachi, Naoki; Yin, Yong-Gen; Suzui, Nobuo; Ishii, Satomi; Fujimaki, Shu [Radiotracer Imaging Gr., Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Yoshihara, Toshihiro [Plant Molecular Biology, Laboratory of Environmental Science, Central Research Institute of Electric Power Industry (CRIEPI), 1646 Abiko, Chiba 270-1194 (Japan); Watabe, Hiroshi [Cyclotron and Radioisotope Center (CYRIC), Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 (Japan); Yamamoto, Seiichi [Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673 (Japan)

    2014-07-01

    Vast agricultural and forest areas around the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station in Japan were contaminated with radiocesium (Cs-134 and Cs-137) after the accident following the earthquake and tsunami in March 2011. A variety of agricultural studies, such as fertilizer management and plant breeding, have been undertaken intensively for reduction of radiocesium uptake in crops, or, enhancement of uptake in phyto-remediation. In this study, we newly developed a gamma camera specific for plant nutritional research, and performed quantitative analyses on uptake and partitioning of radiocesium in intact plant bodies. In general, gamma camera is a common technology in medical imaging, but it is not applicable to high-energy gamma rays such as emissions from Cs-137 (662 keV). Therefore, we designed our new gamma camera to prevent the penetration and scattering of the high-energy gamma rays. A single-crystal scintillator, Ce-doped Gd{sub 3}Al{sub 2}Ga{sub 3}O{sub 12} (Ce:GAGG), was employed, which has a relatively high density, a large light output, no natural radioactivity and no hygroscopicity. A 44 x 44 matrix of the Ce:GAGG pixels, with dimensions of 0.85 mm x 0.85 mm x 10 mm for each pixel, was coupled to a high-quantum efficiency position sensitive photomultiplier tube. This gamma detector unit was encased in a 20-mm-thick tungsten container with a tungsten pinhole collimator on the front. By using this gamma camera, soybean plants (Glycine max), grown in hydroponic solutions and fed with 1-2 MBq of Cs-137, were imaged for 6.5 days in maximum to investigate and visualize the uptake dynamics into/within the areal part. As a result, radiocesium gradually appeared in the shoot several hours after feeding of Cs-137, and then accumulated intensively in the maturing pods and seeds in a characteristic pattern. Our results also demonstrated that this gamma-camera method enables quantitative evaluation of plant ability to absorb, transport

  1. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications

    Energy Technology Data Exchange (ETDEWEB)

    Tsuchimochi, Makoto; Hayama, Kazuhide [Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Dentistry at Niigata, 1-8 Hamaura-cho, 951-8580, Niigata (Japan); Sakahara, Harumi [Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu (Japan); Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi [Acrorad Co. Ltd., Tokyo (Japan); Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar [Integrated Detector and Electronics A.S (IDE AS), Hovik (Norway)

    2003-12-01

    Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mm x 166 mm x 65 mm. The effective visual field was 44.8 mm x 44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV ({sup 99m}Tc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56{+-}0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and

  2. A prototype small CdTe gamma camera for radioguided surgery and other imaging applications

    International Nuclear Information System (INIS)

    Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mm x 166 mm x 65 mm. The effective visual field was 44.8 mm x 44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV (99mTc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56±0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and facilitating

  3. A performance study of an electron-tracking Compton camera with a compact system for environmental gamma-ray observation

    International Nuclear Information System (INIS)

    An electron-tracking Compton camera (ETCC) is a detector that can determine the arrival direction and energy of incident sub-MeV/MeV gamma-ray events on an event-by-event basis. It is a hybrid detector consisting of a gaseous time projection chamber (TPC), that is the Compton-scattering target and the tracker of recoil electrons, and a position-sensitive scintillation camera that absorbs of the scattered gamma rays, to measure gamma rays in the environment from contaminated soil. To measure of environmental gamma rays from soil contaminated with radioactive cesium (Cs), we developed a portable battery-powered ETCC system with a compact readout circuit and data-acquisition system for the SMILE-II experiment [1,2]. We checked the gamma-ray imaging ability and ETCC performance in the laboratory by using several gamma-ray point sources. The performance test indicates that the field of view (FoV) of the detector is about 1 sr and that the detection efficiency and angular resolution for 662 keV gamma rays from the center of the FoV is (9.31 ± 0.95) × 10−5 and 5.9° ± 0.6°, respectively. Furthermore, the ETCC can detect 0.15 μSv/h from a 137Cs gamma-ray source with a significance of 5σ in 13 min in the laboratory. In this paper, we report the specifications of the ETCC and the results of the performance tests. Furthermore, we discuss its potential use for environmental gamma-ray measurements

  4. The Si/CdTe semiconductor Compton camera of the ASTRO-H Soft Gamma-ray Detector (SGD)

    CERN Document Server

    Watanabe, Shin; Fukazawa, Yasushi; Ichinohe, Yuto; Takeda, Shin'ichiro; Enoto, Teruaki; Fukuyama, Taro; Furui, Shunya; Genba, Kei; Hagino, Kouichi; Harayama, Astushi; Kuroda, Yoshikatsu; Matsuura, Daisuke; Nakamura, Ryo; Nakazawa, Kazuhiro; Noda, Hirofumi; Odaka, Hirokazu; Ohta, Masayuki; Onishi, Mitsunobu; Saito, Shinya; Sato, Goro; Sato, Tamotsu; Takahashi, Tadayuki; Tanaka, Takaaki; Togo, Atsushi; Tomizuka, Shinji

    2015-01-01

    The Soft Gamma-ray Detector (SGD) is one of the instrument payloads onboard ASTRO-H, and will cover a wide energy band (60--600 keV) at a background level 10 times better than instruments currently in orbit. The SGD achieves low background by combining a Compton camera scheme with a narrow field-of-view active shield. The Compton camera in the SGD is realized as a hybrid semiconductor detector system which consists of silicon and cadmium telluride (CdTe) sensors. The design of the SGD Compton camera has been finalized and the final prototype, which has the same configuration as the flight model, has been fabricated for performance evaluation. The Compton camera has overall dimensions of 12 cm x 12 cm x 12 cm, consisting of 32 layers of Si pixel sensors and 8 layers of CdTe pixel sensors surrounded by 2 layers of CdTe pixel sensors. The detection efficiency of the Compton camera reaches about 15% and 3% for 100 keV and 511 keV gamma rays, respectively. The pixel pitch of the Si and CdTe sensors is 3.2 mm, and ...

  5. The optimum Ga-67-citrate gamma camera imaging quality factors as first calculated and shown by the Taguchi's analysis.

    Science.gov (United States)

    Yeh, Da Ming; Chang, Pai Jung; Pan, Lung Kwang

    2013-01-01

    In this work gallium-67 ((67)Ga) gamma camera imaging quality was optimized using the Taguchi's analysis and a planar phantom. The acrylic planar phantom was LASER-cut to form groups of slits 1mm wide and 5mm deep, to determine the spatial resolution and contrast ratio that could be achieved in a (67)Ga citrate nuclear medicine examination. The (67)Ga-citrate solution was injected into the slits to form an active radioactive line source which was placed between regular acrylic plates for optimization. Then, nine combinations of four operating factors: L9 (3((4)), of the gamma camera imaging system were used and followed the Taguchi's analysis. The four operating factors were: a) the type of collimator in front of the NaI(Tl) detector, b) the region of interest of (67)Ga gamma rays spectrum, c) the scanning speed of NaI(Tl) detector head and d) the activity of (67)Ga. The original judged grade of the planar phantom image quality was increased 36% and factors a) and b) were confirmed to dominate. The cross interaction among factors was also discussed. Our results showed that the optimal factor settings of the gamma camera imaging system were verified by performing a routine nuclear medicine examination in ten cases. Nine cases showed the same optimal settings as estimated by three highly trained radio-diagnostic physicians. Additionally, the optimal setting yielded clearer images with greater contrast than did the conventional settings. In conclusion, this work suggests for practical use an optimized process for determining both the spatial resolution and the contrast ratio of a gamma camera imaging system using Taguchi's optimal analysis and a planar phantom. The Taguchi's method is most effective in targeting a single quality characteristic but can also be extended to satisfy multiple requirements under specific conditions by revising the definition of signal to noise ratio. PMID:23529390

  6. Value of coincidence gamma camera PET in tumors of the thorax and abdomen and assessment of myocardial viability

    International Nuclear Information System (INIS)

    In this paper we report our experience of the usefulness of FDG scanning using a gamma camera equipped with coincidence detection for staging lung cancer and in the follow-up of patients with colorectal cancer. We also tested the diagnostic accuracy of cardiac FDG imaging. Our results demonstrate that, although a coincidence camera is technically inferior to a dedicated PET scanner, it may provide clinically useful results in situations were a lesion of sufficient size and FDG-uptake is to be expected. In patients with chronic ischemic cardiomyopathy coincidence PET can be introduced into clinical practice for the assessment of myocardial viability. (orig.)

  7. The Si/CdTe semiconductor Compton camera of the ASTRO-H Soft Gamma-ray Detector (SGD)

    OpenAIRE

    Watanabe, Shin; Tajima, Hiroyasu; Fukazawa, Yasushi; Ichinohe, Yuto; Takeda, Shin'ichiro; Enoto, Teruaki; Fukuyama, Taro; Furui, Shunya; Genba, Kei; Hagino, Kouichi; Harayama, Astushi; Kuroda, Yoshikatsu; Matsuura, Daisuke; Nakamura, Ryo; Nakazawa, Kazuhiro

    2015-01-01

    The Soft Gamma-ray Detector (SGD) is one of the instrument payloads onboard ASTRO-H, and will cover a wide energy band (60--600 keV) at a background level 10 times better than instruments currently in orbit. The SGD achieves low background by combining a Compton camera scheme with a narrow field-of-view active shield. The Compton camera in the SGD is realized as a hybrid semiconductor detector system which consists of silicon and cadmium telluride (CdTe) sensors. The design of the SGD Compton...

  8. Measuring neutron fluences and gamma/x-ray fluxes with CCD cameras

    International Nuclear Information System (INIS)

    The capability to measure bursts of neutron fluences and gamma/x-ray fluxes directly with charge coupled device (CCD) cameras while being able to distinguish between the video signals produced by these two types of radiation, even when they occur simultaneously, has been demonstrated. Volume and area measurements of transient radiation-induced pixel charge in English Electric Valve (EEV) Frame Transfer (FT) charge coupled devices (CCDs) from irradiation with pulsed neutrons (14 MeV) and Bremsstrahlung photons (4--12 MeV endpoint) are utilized to calibrate the devices as radiometric imaging sensors capable of distinguishing between the two types of ionizing radiation. Measurements indicate ∼.05 V/rad responsivity with ≥1 rad required for saturation from photon irradiation. Neutron-generated localized charge centers or ''peaks'' binned by area and amplitude as functions of fluence in the 105 to 107 n/cm2 range indicate smearing over ∼1 to 10% of CCD array with charge per pixel ranging between noise and saturation levels

  9. Three-head positron coincidence detection (γ PET) by PRISM-IRIX gamma camera system

    International Nuclear Information System (INIS)

    The Shimadzu PRISM-IRIX is a three-headed variable-angle gamma camera system that also ensures the highest performances in single photon emission computed tomography (SPECT). It provides not only single photon imaging, but also positron coincidence imaging, by using two of the three heads. We have successfully improved the hardware and software of this system, so that the system fully utilizes all of the three heads in order to perform more reliable positron coincidence imaging. Also, we utilized the method of computer simulation to find out the head configuration that ensures the highest performances. Our investigations have shown that the triangular head configuration ensures the highest performances and stability of results in examinations of small organs where the rotation angle is set to 15 cm and that the C-mode head configuration gives the highest stability in examinations of larger organs where the rotation angle is set to 30 cm. We have further improved the electronic circuitry of the head to establish a system called AZTec (adaptive zone technology system). This system ensures even higher coincidence efficiency and higher performances in general. (author)

  10. Radioguided Parathyroidectomy with Portable Mini Gamma-Camera for the Treatment of Primary Hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Claudio Casella

    2015-01-01

    Full Text Available Background. A proper localisation of pathological parathyroid glands is essential for a minimally invasive approach in the surgical treatment of primary hyperparathyroidism (PHP. The recent introduction of portable mini gamma-cameras (pMGCs enabled intraoperative scintigraphic scanning. The aim of our study is to evaluate the efficacy of this new method and compare it with the preoperative localisation surveys. Methods. 20 patients were studied; they were evaluated preoperatively by neck ultrasound and Tc-sestaMIBI-scintigraphy and intraoperatively with the pMGC IP Guardian 2. The results obtained from the three evaluations were compared. Results. The pMGC presented a sensitivity of 95%, a specificity of 98.89%, and a diagnostic accuracy of 98.18%, which were higher than those of preoperative ultrasound (sensitivity 55%; specificity 95%; diagnostic accuracy 87% and scintigraphy with Tc-sestaMIBI (sensitivity 73.68%; specificity 96.05%; diagnostic accuracy 91.58%. Conclusions. The pMGC can be used effectively as an intraoperative method to find the correct location of the pathological parathyroid glands. The pMGC is more reliable than the currently used preoperative and intraoperative localisation techniques.

  11. The review of myocardial positron emission computed tomography and positron imaging by gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Ohtake, Tohru [Tokyo Univ. (Japan). Faculty of Medicine

    1998-04-01

    To measure myocardial blood flow, Nitrogen-13 ammonia, Oxygen-15 water, Rubidium-82 and et al. are used. Each has merit and demerit. By measuring myocardial coronary flow reserve, the decrease of flow reserve during dipyridamole in patients with hypercholesterolemia or diabetes mellitus without significant coronary stenosis was observed. The possibility of early detection of atherosclerosis was showed. As to myocardial metabolism, glucose metabolism is measured by Fluorine-18 fluorodeoxyglucose (FDG), and it is considered as useful for the evaluation of myocardial viability. We are using FDG to evaluate insulin resistance during insulin clamp in patients with diabetes mellitus by measuring glucose utilization rate of myocardium and skeletal muscle. FFA metabolism has been measured by {sup 11}C-palmitate, but absolute quantification has not been performed. Recently the method for absolute quantification was reported, and new radiopharmaceutical {sup 18}F-FTHA was reported. Oxygen metabolism has been estimated by {sup 11}C-acetate. Myocardial viability, cardiac efficiency was evaluated by oxygen metabolism. As to receptor or sympathetic nerve end, cardiac insufficiency or cardiac transplantation was evaluated. Imaging of positron emitting radiopharmaceutical by gamma camera has been performed. Collimator method is clinically useful for cardiac imaging of viability study. (author). 54 refs.

  12. Evaluation of the scattered radiation components produced in a gamma camera using Monte Carlo method

    Energy Technology Data Exchange (ETDEWEB)

    Polo, Ivon Oramas, E-mail: ivonoramas67@gmail.com [Department of Nuclear Engineering, Faculty of Nuclear Sciences and Technologies, Higher Institute of Applied Science and Technology (InSTEC), La Habana (Cuba)

    2014-07-01

    Introduction: this paper presents a simulation for evaluation of the scattered radiation components produced in a gamma camera PARK using Monte Carlo code SIMIND. It simulates a whole body study with MDP (Methylene Diphosphonate) radiopharmaceutical based on Zubal anthropomorphic phantom, with some spinal lesions. Methods: the simulation was done by comparing 3 configurations for the detected photons. The corresponding energy spectra were obtained using Low Energy High Resolution collimator. The parameters related with the interactions and the fraction of events in the energy window, the simulated events of the spectrum and scatter events were calculated. Results: the simulation confirmed that the images without influence of scattering events have a higher number of valid recorded events and it improved the statistical quality of them. A comparison among different collimators was made. The parameters and detector energy spectrum were calculated for each simulation configuration with these collimators using {sup 99m}Tc. Conclusion: the simulation corroborated that LEHS collimator has higher sensitivity and HEHR collimator has lower sensitivity when they are used with low energy photons. (author)

  13. The review of myocardial positron emission computed tomography and positron imaging by gamma camera

    International Nuclear Information System (INIS)

    To measure myocardial blood flow, Nitrogen-13 ammonia, Oxygen-15 water, Rubidium-82 and et al. are used. Each has merit and demerit. By measuring myocardial coronary flow reserve, the decrease of flow reserve during dipyridamole in patients with hypercholesterolemia or diabetes mellitus without significant coronary stenosis was observed. The possibility of early detection of atherosclerosis was showed. As to myocardial metabolism, glucose metabolism is measured by Fluorine-18 fluorodeoxyglucose (FDG), and it is considered as useful for the evaluation of myocardial viability. We are using FDG to evaluate insulin resistance during insulin clamp in patients with diabetes mellitus by measuring glucose utilization rate of myocardium and skeletal muscle. FFA metabolism has been measured by 11C-palmitate, but absolute quantification has not been performed. Recently the method for absolute quantification was reported, and new radiopharmaceutical 18F-FTHA was reported. Oxygen metabolism has been estimated by 11C-acetate. Myocardial viability, cardiac efficiency was evaluated by oxygen metabolism. As to receptor or sympathetic nerve end, cardiac insufficiency or cardiac transplantation was evaluated. Imaging of positron emitting radiopharmaceutical by gamma camera has been performed. Collimator method is clinically useful for cardiac imaging of viability study. (author). 54 refs

  14. Optimization of a parallel hole collimator/CdZnTe gamma-camera architecture for scintimammography

    International Nuclear Information System (INIS)

    Purpose: Small field-of-view CdZnTe (CZT) gamma cameras are increasingly studied for breast lesion detection to complement mammography or ultrasonographic findings. However, in classical collimation configurations, they remain limited by the trade-off between spatial resolution and sensitivity. The HiSens architecture was proposed to overcome these limitations. Using an accurate 3D localization of the interactions inside the detector, this architecture leads to a gain in sensitivity without loss in spatial resolution. In this article, the relevance of the HiSens architecture for planar scintimammography is studied. Methods: A detective quantum efficiency (DQE) computation method is developed and used to optimize the dimensioning of a parallel hole collimator dedicated to scintimammography. Based on the DQE curves, the impact of the collimator-to-detector distance is studied. Two algorithms are proposed to combine data acquired with different collimator-to-detector distances. Results: It is shown that CZT detector virtual pixelization increases system sensitivity by 3.3 while preserving a standard LEHR spatial resolution. The introduction of a gap between the CZT detector and the collimator is useful to modulate the DQE curve shape. The combination of data acquired using different gaps in the image formation process leads to enhanced restoration of the frequency content of the images, resulting in image contrast and spatial resolution improvements. Conclusions: Acquisition duration or injected activity could be markedly reduced if the HiSens architecture with an appropriate collimator-detector gap were used.

  15. Studies on tear physiology, pathophysiology and contact lenses by means of dynamic gamma camera and technetium

    International Nuclear Information System (INIS)

    In the present work the tracer method has been evaluated in a normal population. The effect of head and body position has been investigated as well as the effect of eye closure on tear drainage. A common, commercial available equipment has been used and a position and fixation of the patient has been chosen making the tear flow study possible in most persons. The clinical study in patients with lacrimal disorders showed the method being most applicable in pre-sac stenosis cases, i.e. in persons suffering watery eyes though having a normal passage to irrigation. The method being non-invasive and without pain is an excellent tool in the evaluation of tear drainage problems in children. Though a tear flow curve may not be obtained, scintigrams often leed to solid information to the ophthalmologist. In recent years the contact lens - drug relation has been a subject of growing interest. The tracer method applied on contact lens fitted persons yielded some information on the exchange of solutes in contact lens material in vivo. These studies can possibly be extended by marking drugs with technetium to clarify the exchange of the particular drug from the particular contact lens - an exchange that at present seems rather unpredictable. It also seems possible to extent flow studies to the inner eye using technetium and gamma camera with dosimetric precautions. It might be fairly easy to determine aqueous flow by this method. (author)

  16. Observation of Diffuse Cosmic and Atmospheric Gamma Rays at Balloon Altitudes with an Electron-tracking Compton Camera

    CERN Document Server

    Takada, Atsushi; Nishimura, Hironobu; Ueno, Kazuki; Hattori, Kaori; Kabuki, Shigeto; Kurosawa, Shunsuke; Miuchi, Kentaro; Mizuta, Eiichi; Nagayoshi, Tsutomu; Nonaka, Naoki; Okada, Yoko; Orito, Reiko; Sekiya, Hiroyuki; Takeda, Atsushi; Tanimori, Toru

    2011-01-01

    We observed diffuse cosmic and atmospheric gamma rays at balloon altitudes with the Sub-MeV gamma-ray Imaging Loaded-on-balloon Experiment I (SMILE-I) as the first step toward a future all-sky survey with a high sensitivity. SMILE-I employed an electron-tracking Compton camera comprised of a gaseous electron tracker as a Compton-scattering target and a scintillation camera as an absorber. The balloon carrying the SMILE-I detector was launched from the Sanriku Balloon Center of the Institute of Space and Astronomical Science/Japan Space Exploration Agency on September 1, 2006, and the flight lasted for 6.8 hr, including level flight for 4.1 hr at an altitude of 32-35 km. During the level flight, we successfully detected 420 downward gamma rays between 100 keV and 1 MeV at zenith angles below 60 degrees. To obtain the flux of diffuse cosmic gamma rays, we first simulated their scattering in the atmosphere using Geant4, and for gamma rays detected at an atmospheric depth of 7.0 g cm-2, we found that 50% and 21% ...

  17. A high resolution Small Field Of View (SFOV) gamma camera: a columnar scintillator coated CCD imager for medical applications

    International Nuclear Information System (INIS)

    We describe a high resolution, small field of view (SFOV), Charge Coupled Device (CCD) based camera for imaging small volumes of radionuclide uptake in tissues. The Mini Gamma Ray Camera (MGRC) is a collimated, scintillator-coated, low cost, high performance imager using low noise CCDs. The prototype MGRC has a 600 μm thick layer of columnar CsI(Tl) and operates in photon counting mode using a thermoelectric cooler to achieve an operating temperature of - 10deg C. Collimation was performed using a pin hole collimator. We have measured the spatial resolution, energy resolution and efficiency using a number of radioisotope sources including 140 keV gamma-rays from 99mTc in a specially designed phantom. We also describe our first imaging of a volunteer patient.

  18. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Balt, A.P.; Brekel, L.D.M. van den; Vandecasteele, C.; Kolar, Z.

    1987-01-01

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine.

  19. Radiotracer study of wash load movement in a drum-type fabric washing machine using a gamma camera

    International Nuclear Information System (INIS)

    A study was made of the movement of the wash loads in a drum-type washing machine. For this purpose a sup(99m)Tc source was attached to one or two separate textile pieces and the subsequent source positions were determined by means of a gamma-camera. The wash load movement pattern appears to depend on the type of textile material and its amount, as well as on the volume of water present in the washing machine. (author)

  20. Intraoperative Scintigraphy Using a Large Field-of-View Portable Gamma Camera for Primary Hyperparathyroidism: Initial Experience

    OpenAIRE

    Hall, Nathan C.; Plews, Robert L.; Amit Agrawal; Povoski, Stephen P.; Chadwick L. Wright; Jun Zhang; Martin, Edward W.; John Phay

    2015-01-01

    Background. We investigated a novel technique, intraoperative 99 mTc-Sestamibi (MIBI) imaging (neck and excised specimen (ES)), using a large field-of-view portable gamma camera (LFOVGC), for expediting confirmation of MIBI-avid parathyroid adenoma removal. Methods. Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to incision (neck) and immediately following resection (neck and/or ES). Preoperative and intraoperative s...

  1. Feasibility of the gamma camera acceptance testing procedure introduced by the Swiss Federal Office of public health

    International Nuclear Information System (INIS)

    Like in the field of radiology, digital systems are also becoming the standard in the field of nuclear medicine. This offers not only the possibility to process, transmit and archive data from patients more easily but also to introduce quantitative measurements for quality controls. In this framework, standards concerning the qualification of gamma camera systems have been updated and appeared to be useful to set legal requirements, in spite of the fact, that this is not their goals. The aim of this study was first to choose a set of tests described in standards to define measurements to be performed at the acceptance of the systems and after the regular maintenance (at least once every six months). Reference values are then established to control the stability of the system. To verify the feasibility, from a technical and a time requirements points of view, the tests proposed for the quality assurance programme have been applied on three gamma camera systems. The results of this study show that new requirements concerning the quality assurance of gamma camera of the Swiss Federal Office of Public Health based on international standards required to slightly modify some procedures to reduce the time necessary for the acceptance and status tests. (authors)

  2. Feasibility of the gamma camera acceptance testing procedure introduced by the Swiss Federal Office of public health

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, S.; Bochud, F.; Verdun, F.R. [University Institute for Radiation Physics, Lausanne (Switzerland); Corminboeuf, F. [Klinik and Poliklinik fur Nuklearmedizin der Universitat, Inselspital, Bern (Switzerland); Linder, R.; Trueb, Ph. [Swiss Federal Office of Public Health, Bern (Switzerland); Malterre, J.; Bischof Delaloye, A. [University Hospital of Lausanne (CHUV), Nuclear Medicine Dept., Lausanne (Switzerland)

    2006-07-01

    Like in the field of radiology, digital systems are also becoming the standard in the field of nuclear medicine. This offers not only the possibility to process, transmit and archive data from patients more easily but also to introduce quantitative measurements for quality controls. In this framework, standards concerning the qualification of gamma camera systems have been updated and appeared to be useful to set legal requirements, in spite of the fact, that this is not their goals. The aim of this study was first to choose a set of tests described in standards to define measurements to be performed at the acceptance of the systems and after the regular maintenance (at least once every six months). Reference values are then established to control the stability of the system. To verify the feasibility, from a technical and a time requirements points of view, the tests proposed for the quality assurance programme have been applied on three gamma camera systems. The results of this study show that new requirements concerning the quality assurance of gamma camera of the Swiss Federal Office of Public Health based on international standards required to slightly modify some procedures to reduce the time necessary for the acceptance and status tests. (authors)

  3. The Si/CdTe semiconductor Compton camera of the ASTRO-H Soft Gamma-ray Detector (SGD)

    International Nuclear Information System (INIS)

    The Soft Gamma-ray Detector (SGD) is one of the instrument payloads onboard ASTRO-H, and will cover a wide energy band (60–600 keV) at a background level 10 times better than instruments currently in orbit. The SGD achieves low background by combining a Compton camera scheme with a narrow field-of-view active shield. The Compton camera in the SGD is realized as a hybrid semiconductor detector system which consists of silicon and cadmium telluride (CdTe) sensors. The design of the SGD Compton camera has been finalized and the final prototype, which has the same configuration as the flight model, has been fabricated for performance evaluation. The Compton camera has overall dimensions of 12 cm×12 cm×12 cm, consisting of 32 layers of Si pixel sensors and 8 layers of CdTe pixel sensors surrounded by 2 layers of CdTe pixel sensors. The detection efficiency of the Compton camera reaches about 15% and 3% for 100 keV and 511 keV gamma rays, respectively. The pixel pitch of the Si and CdTe sensors is 3.2 mm, and the signals from all 13,312 pixels are processed by 208 ASICs developed for the SGD. Good energy resolution is afforded by semiconductor sensors and low noise ASICs, and the obtained energy resolutions with the prototype Si and CdTe pixel sensors are 1.0–2.0 keV (FWHM) at 60 keV and 1.6–2.5 keV (FWHM) at 122 keV, respectively. This results in good background rejection capability due to better constraints on Compton kinematics. Compton camera energy resolutions achieved with the final prototype are 6.3 keV (FWHM) at 356 keV and 10.5 keV (FWHM) at 662 keV, which satisfy the instrument requirements for the SGD Compton camera (better than 2%). Moreover, a low intrinsic background has been confirmed by the background measurement with the final prototype. - Highlights: • The final prototype of the Si/CdTe Compton camera for the ASTRO-H SGD was completed. • The detailed design of the Compton camera is described. • The unprecedented high efficiency and high

  4. X-ray and gamma-ray camera with scintillator block with inlet window of mechanically rigid material transparent to the radiation

    International Nuclear Information System (INIS)

    Improvement has been brought to an X and gamma-ray camera, whose scintillator block has an inlet window of mechanically rigid material weakling absorbing these radiations. The inlet window is made in a light metal with a honeycomb structure

  5. Monitoring system for isolated limb perfusion based on a portable gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Orero, A.; Muxi, A.; Rubi, S.; Duch, J. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Vidal-Sicart, S.; Pons, F. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Inst. d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona (Spain); Red Tematica de Investigacion Cooperativa en Cancer (RTICC), Barcelona (Spain); Roe, N. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona (Spain); Rull, R. [Servei de Cirurgia, Hospital Clinic, Barcelona (Spain); Pavon, N. [Inst. de Fisica Corpuscular, CSIC - UV, Valencia (Spain); Pavia, J. [Servei de Medicina Nuclear, Hospital Clinic, Barcelona (Spain); Inst. d' Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona (Spain); CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona (Spain)

    2009-07-01

    Background: The treatment of malignant melanoma or sarcomas on a limb using extremity perfusion with tumour necrosis factor (TNF-{alpha}) and melphalan can result in a high degree of systemic toxicity if there is any leakage from the isolated blood territory of the limb into the systemic vascular territory. Leakage is currently controlled by using radiotracers and heavy external probes in a procedure that requires continuous manual calculations. The aim of this work was to develop a light, easily transportable system to monitor limb perfusion leakage by controlling systemic blood pool radioactivity with a portable gamma camera adapted for intraoperative use as an external probe, and to initiate its application in the treatment of MM patients. Methods: A special collimator was built for maximal sensitivity. Software for acquisition and data processing in real time was developed. After testing the adequacy of the system, it was used to monitor limb perfusion leakage in 16 patients with malignant melanoma to be treated with perfusion of TNF-{alpha} and melphalan. Results: The field of view of the detector system was 13.8 cm, which is appropriate for the monitoring, since the area to be controlled was the precordial zone. The sensitivity of the system was 257 cps/MBq. When the percentage of leakage reaches 10% the associated absolute error is {+-}1%. After a mean follow-up period of 12 months, no patients have shown any significant or lasting side-effects. Partial or complete remission of lesions was seen in 9 out of 16 patients (56%) after HILP with TNF-{alpha} and melphalan. Conclusion: The detector system together with specially developed software provides a suitable automatic continuous monitoring system of any leakage that may occur during limb perfusion. This technique has been successfully implemented in patients for whom perfusion with TNF-{alpha} and melphalan has been indicated. (orig.)

  6. Evaluation of gamma camera-based measurement of individual kidney function using iodine-123 orthoiodohippurate

    International Nuclear Information System (INIS)

    To evaluate the accuracy of these techniques, we measured RUR by an optimized procedure and compared it with standard ERPF. Iodine-123 orthoiodohippurate (OIH) scintigraphy and simultaneous para-aminohippurate clearance study for measuring standard ERPF were performed in three hospitals in 24 patients with normal or mildly impaired renal function. 123I-OIH was injected intravenously and 10-s consecutive imaging of the kidneys was started when the abdominal aorta was seen. The attenuation coefficient for 123I was measured in each hospital using the same water-equivalent absorption materials and used for the attenuation correction. After subtracting background radioactivity, RURs were defined as the count ratios of fractional renal uptakes based on the integral from 1 to 2, 2 to 3, 1.5 to 2.5 and 1 to 3 min after the injection of 123I-OIH in relation to injected doses using the following three procedures in respect of attenuation correction: (1) RUR without attenuation correction, (2) RUR with fractional renal uptake corrected by the measured attenuation coefficient, (3) RUR with the total injected dose corrected by the absorption material. To decide upon the appropriate correction method and time interval, RURs were compared with standard ERPF. Among the three correction methods, procedure 2 showed the highest correlation between RUR and standard ERPF, but the correlation coefficient was low (r=0.75). No significant difference was observed among the RURs of each time interval. Individual kidney function measured from early renal uptake may be inaccurate even when appropriate correction is made for attenuation, background activity or time lag between injection and data acquisition. Gamma camera-based measurement of renal function using 123I-OIH is limited with regard to accuracy and reproducibility, though it is convenient and non-invasive. (orig.). With 2 figs., 2 tabs

  7. Radionuclide examination of the cerebral circulation with the 'Fucks-Knipping Gamma-Camera'

    International Nuclear Information System (INIS)

    In order to analyze cerebral blood flow for diagnostic purposes, Indium 113m-DTPA was i.v. injected into seated patients, and time-activity curves were registered by a multifacet gamma camera (Fucks-Knipping) form 8 regions of interest, from the median area and from the right and left side of the head: 3 from the hemisphere, 3 from the brain stem, 2 from the large arteries of the neck. The results from 14 patients with chronic impairment of cerebral blood flow were compared with normal data from 20 healthy individuals. The time activity curves were analyzed for peak-height, mean transit time, and ratio peak to plateau height. The individual parameters were investigated for the degree of their correlation in a multiparameter system. The results from the patients indicated for the different single parameters a non-uniform response. There was also no correlation between the deviation of different parameters, between single pathological parameters and the degree and the site of blood flow impairment. On the other hand, a positive correlation was found between the number of pathological parameters and the degree of blood flow impairment irrespective of the site of its localization. Reason for this result probably is the variable location and degree of blood flow compensation by collaterals, which predominantly are expected at the cerebral base. The data indicate the potential usefulness of the application of the multiparameter analysis to quantitatively detect the degree of impairment of cerebral blood flow without regard to its topography. In this respect, the method, here described, promises to be of clinical value for non-invasive and non-hazardous diagnostic screening of cerebral blood flow. (orig.)

  8. MeV gamma-ray Compton camera using a gaseous electron tracker for background-suppressed observation

    Science.gov (United States)

    Takada, A.; Tanimori, T.; Kubo, H.; Parker, J. D.; Mizumoto, T.; Mizumura, Y.; Sawano, T.; Nakamura, K.; Matsuoka, Y.; Komura, S.; Nakamura, S.; Oda, M.; Miuchi, K.; Kurosawa, S.

    2014-07-01

    As a next generation MeV gamma-ray telescope, we develop an electron-tracking Compton camera (ETCC) that consists of a gaseous electron tracker surrounded by pixel scintillator arrays. The tracks of the Compton-recoil electron measured by the tracker restrict the incident gamma-ray direction to an arc region on the sky and reject background by using the energy loss rate dE/dx and a Compton-kinematics test. In 2013, we constructed, for a balloon experiment, a 30-cm-cubic ETCC with an effective area of ~1 cm2 for detecting sub-MeV gamma rays (5 σ detection of the Crab Nebula for 4 h). In future work, we will extend this ETCC to an effective area of ~10 cm2. In the present paper, we report the performance of the current ETCC.

  9. The possibilities of autoradiographic imaging of the distribution of beta-emitting substances in dynamic processes by means of a gamma scintillation camera

    International Nuclear Information System (INIS)

    Possibilities of imaging the distribution of beta-emitting substances by means of a gamma scintillation camera are described. The sensitivity and the resolving power of the gamma scintillation camera was tested by means of a 140 KeV-high resolution collimator and a newly developed lead collimator with smaller hole diameter and hole distance. As an example for tests of imaging dynamic processes the transportation of 32P-labelled defoliant in a tomato plant is examined. (author)

  10. Development of a phantom and assessment of (141)Ce as a surrogate radionuclide for flood field uniformity testing of gamma cameras.

    Science.gov (United States)

    Saxena, Sanjay Kumar; Kumar, Yogendra; Malpani, Basant; Rakshit, Sutapa; Dash, Ashutosh

    2016-06-01

    This paper describes an indigenous method for development and deployment of rechargeable liquid filled phantom with newly proposed radionuclide (141)Ce for determination of extrinsic uniformity of gamma cameras. Details about design of phantom, neutron irradiation of cerium targets, chemical processing of (141)Ce, charging of phantom with (141)Ce solution and their performance evaluation are presented. Suitability of (141)Ce in quality assurance of gamma cameras used in in-vivo diagnostic imaging procedures has been amply demonstrated. PMID:27031297

  11. Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera

    OpenAIRE

    Buechel, R R; Pazhenkottil, A P; Herzog, B A; Husmann, L; Nkoulou, R N; Burger, I A; Valenta, I; Wyss, C A; Ghadri, J R; Kaufmann, P A

    2010-01-01

    PURPOSE: The aim of this study was to assess the ability of real-time breath-hold-triggered myocardial perfusion imaging (MPI) using a novel cadmium-zinc-telluride (CZT) gamma camera to discriminate artefacts from true perfusion defects. METHODS: A group of 40 patients underwent a 1-day (99m)Tc-tetrofosmin pharmacological stress/rest imaging protocol on a conventional dual detector SPECT gamma camera with and without attenuation correction (AC), immediately followed by scanning on an ultrafas...

  12. Gamma-camera 18F-FDG PET in diagnosis and staging of patients presenting with suspected lung cancer and comparison with dedicated PET

    DEFF Research Database (Denmark)

    Oturai, Peter S; Mortensen, Jann; Enevoldsen, Henriette; Eigtved, Annika; Backer, Vibeke; Olesen, Knud P; Nielsen, Henrik W; Hansen, Hanne; Stentoft, Poul; Friberg, Lars

    2004-01-01

    It is not clear whether high-quality coincidence gamma-PET (gPET) cameras can provide clinical data comparable with data obtained with dedicated PET (dPET) cameras in the primary diagnostic work-up of patients with suspected lung cancer. This study focuses on 2 main issues: direct comparison...

  13. Impact of the Pixel Pitch of the Timepix Chip Integrated to the GAMPIX Gamma Camera for Spectrometric and Imaging Performances

    International Nuclear Information System (INIS)

    Spatial localization and identification of radioactive sources is a main issue interesting Homeland Security. Gamma imaging allows reaching this need. A new gamma camera, GAMPIX, has been designed by the French Atomic Energy Commission (CEA). GAMPIX enables spatial localization of hot spots on a large energy range. Sensitivity, portability (2 kg) and ergonomics were improved in comparison with previous industrial systems. The detection system is based on the 1.4 cm side Timepix pixelated readout chip developed by CERN and hybridized to a 1 mm thick CdTe substrate. Pixel size of the Timepix chip is 55 μm or 110 μm. Ongoing developments concern the addition of a spectrometric capability to the existing system. The challenge is the optimization of spectrometric performances while maintaining imaging performances. Our work intends to assess the impact of pixel pitch by means of simulations and experimental validation. A large range of pixel pitch and energies were tested by MCNPX simulations. Fluorescence impact depending on pixel pitch was demonstrated. Pixel pitch impact on imaging performances was also studied. The purpose is to preserve the angular resolution of the GAMPIX gamma camera, i.e., the ability to separate radioactive sources spatially close. Energy calibration of Timepix detectors is crucial for the optimization of spectrometric performances. The small pixel size compared to the substrate thickness induces charge depositions in several pixels, called clusters, and the shift between spectra due to different cluster sizes degrades the energy resolution. The energy calibration of our Timepix detectors was carried out in the SOLEX tunable monochromatic X-ray source (CEA). Our developments show that the replacement of the 55 μm pixelated Timepix chip currently used in the GAMPIX gamma camera by a 110 μm pixel pitch would lead to a significant improvement in terms of spectrometric performances without degrading imaging abilities. (author)

  14. The interfacing of a gamma camera to a DEC Gamma-11 data processing system for single-photon emission tomography

    International Nuclear Information System (INIS)

    This data processing system incorporates Gamma-11, the DEC nuclear medicine software package, which runs under the RT-11 foreground/background operating system employing two video terminals. The interface is designed so that no modification to the Gamma-11 system is required. (author)

  15. Measurement of prompt gamma profiles in inhomogeneous targets with a knife-edge slit camera during proton irradiation

    Science.gov (United States)

    Priegnitz, M.; Helmbrecht, S.; Janssens, G.; Perali, I.; Smeets, J.; Vander Stappen, F.; Sterpin, E.; Fiedler, F.

    2015-06-01

    Proton and ion beam therapies become increasingly relevant in radiation therapy. To fully exploit the potential of this irradiation technique and to achieve maximum target volume conformality, the verification of particle ranges is highly desirable. Many research activities focus on the measurement of the spatial distributions of prompt gamma rays emitted during irradiation. A passively collimating knife-edge slit camera is a promising option to perform such measurements. In former publications, the feasibility of accurate detection of proton range shifts in homogeneous targets could be shown with such a camera. We present slit camera measurements of prompt gamma depth profiles in inhomogeneous targets. From real treatment plans and their underlying CTs, representative beam paths are selected and assembled as one-dimensional inhomogeneous targets built from tissue equivalent materials. These phantoms have been irradiated with monoenergetic proton pencil beams. The accuracy of range deviation estimation as well as the detectability of range shifts is investigated in different scenarios. In most cases, range deviations can be detected within less than 2 mm. In close vicinity to low-density regions, range detection is challenging. In particular, a minimum beam penetration depth of 7 mm beyond a cavity is required for reliable detection of a cavity filling with the present setup. Dedicated data post-processing methods may be capable of overcoming this limitation.

  16. Investigations of the variation of the detection probability of gamma cameras

    International Nuclear Information System (INIS)

    It is shown that in the wide-spread measurement of camera properties by flooding, inhomogeneities in the counting rates are mostly due to inhomogeneities in the imaging characteristics. Correction by flooding measurements is therefore not practicable for the evaluation of ROI measurements. Anger cameras should be tested by point source measurements. (ORU)

  17. Influence of optical and geometrical parameters on scintillation detection in gamma camera heads

    International Nuclear Information System (INIS)

    By using a computer simulation program developed for the study of the light collection by photomultiplier tubes in scintillation cameras, the influence of various optical and geometrical parameters of the camera head on the scintillation detection process is examined. In particular, the effect of useful parameters for camera head design such as light guide thickness, photocathode diameter and scintillating crystal, on the PMT response as a function of the distance 'scintillation point - PMT axis' are given. Some parameters inaccessible to experimentation are computed such as the relative contribution of direct light to the total amount collected by PM tubes, the distribution of incidence angles of photon tracks reaching the photocathodes as well as the photon irradiance over the output plane of the camera optical block. In addition, the computed statistical results delivered by this simulation program allow appraisal of the practical limits of the intrinsic spatial resolution of scintillation cameras

  18. Dual-head gamma camera system for intraoperative localization of radioactive seeds

    Science.gov (United States)

    Arsenali, B.; de Jong, H. W. A. M.; Viergever, M. A.; Dickerscheid, D. B. M.; Beijst, C.; Gilhuijs, K. G. A.

    2015-10-01

    Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that the number of incomplete excisions can be reduced even further if intraoperative information about the location of the radioactive seed is combined with preoperative information about the extent of the tumor. This can be combined if the location of the radioactive seed is established in a world coordinate system that can be linked to the (preoperative) image coordinate system. With this in mind, we propose a radioactive seed localization system which is composed of two static ceiling-suspended gamma camera heads and two parallel-hole collimators. Physical experiments and computer simulations which mimic realistic clinical situations were performed to estimate the localization accuracy (defined as trueness and precision) of the proposed system with respect to collimator-source distance (ranging between 50 cm and 100 cm) and imaging time (ranging between 1 s and 10 s). The goal of the study was to determine whether or not a trueness of 5 mm can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (these specifications were defined by a group of dedicated breast cancer surgeons). The results from the experiments indicate that the location of the radioactive seed can be established with an accuracy of 1.6 mm  ±  0.6 mm if a collimator-source distance of 50 cm and imaging time of 5 s are used (these experiments were performed with a 4.5 cm thick block phantom). Furthermore, the results from the simulations indicate that a trueness of 3.2 mm or less can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (this trueness was achieved for all 14 breast phantoms which

  19. Dual-head gamma camera system for intraoperative localization of radioactive seeds

    International Nuclear Information System (INIS)

    Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that the number of incomplete excisions can be reduced even further if intraoperative information about the location of the radioactive seed is combined with preoperative information about the extent of the tumor. This can be combined if the location of the radioactive seed is established in a world coordinate system that can be linked to the (preoperative) image coordinate system. With this in mind, we propose a radioactive seed localization system which is composed of two static ceiling-suspended gamma camera heads and two parallel-hole collimators. Physical experiments and computer simulations which mimic realistic clinical situations were performed to estimate the localization accuracy (defined as trueness and precision) of the proposed system with respect to collimator-source distance (ranging between 50 cm and 100 cm) and imaging time (ranging between 1 s and 10 s). The goal of the study was to determine whether or not a trueness of 5 mm can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (these specifications were defined by a group of dedicated breast cancer surgeons). The results from the experiments indicate that the location of the radioactive seed can be established with an accuracy of 1.6 mm  ±  0.6 mm if a collimator-source distance of 50 cm and imaging time of 5 s are used (these experiments were performed with a 4.5 cm thick block phantom). Furthermore, the results from the simulations indicate that a trueness of 3.2 mm or less can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (this trueness was achieved for all 14 breast phantoms which

  20. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation

    International Nuclear Information System (INIS)

    To assess the diagnostic performance of a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors for nuclear myocardial perfusion imaging (MPI). The study group comprised 75 consecutive patients (55 men, BMI range 19-45 kg/m2) who underwent a 1-day 99mTc-tetrofosmin adenosine-stress/rest imaging protocol. Scanning was performed first on a conventional dual-detector SPECT gamma camera (Ventri, GE Healthcare) with a 15-min acquisition time each for stress and rest. All scans were immediately repeated on an ultrafast CZT camera (Discovery 530 NMc, GE Healthcare) with a 3-min scan time for stress and a 2-min scan time for rest. Clinical agreement (normal, ischaemia, scar) between CZT and SPECT was assessed for each patient and for each coronary territory using SPECT MPI as the reference standard. Segmental myocardial tracer uptake values (percent of maximum) using a 20-segment model and left ventricular ejection fraction (EF) values obtained using CZT were compared with those obtained using conventional SPECT by intraclass correlation and by calculating Bland-Altman limits of agreement. There was excellent clinical agreement between CZT and conventional SPECT on a per-patient basis (96.0%) and on a per-vessel territory basis (96.4%) as shown by a highly significant correlation between segmental tracer uptake values (r=0.901, p<0.001). Similarly, EF values for both scanners were highly correlated (r=0.976, p<0.001) with narrow Bland-Altman limits of agreement (-5.5-10.6%). The novel CZT camera allows a more than fivefold reduction in scan time and provides clinical information equivalent to conventional standard SPECT MPI. (orig.)

  1. Ultrafast nuclear myocardial perfusion imaging on a new gamma camera with semiconductor detector technique: first clinical validation

    Energy Technology Data Exchange (ETDEWEB)

    Buechel, Ronny R.; Herzog, Bernhard A.; Husmann, Lars; Burger, Irene A.; Pazhenkottil, Aju P.; Treyer, Valerie; Valenta, Ines; Schulthess, Patrick von; Nkoulou, Rene; Wyss, Christophe A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University of Zurich, Zurich Center for Integrative Human Physiology (ZIHP), Zurich (Switzerland)

    2010-04-15

    To assess the diagnostic performance of a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors for nuclear myocardial perfusion imaging (MPI). The study group comprised 75 consecutive patients (55 men, BMI range 19-45 kg/m{sup 2}) who underwent a 1-day {sup 99m}Tc-tetrofosmin adenosine-stress/rest imaging protocol. Scanning was performed first on a conventional dual-detector SPECT gamma camera (Ventri, GE Healthcare) with a 15-min acquisition time each for stress and rest. All scans were immediately repeated on an ultrafast CZT camera (Discovery 530 NMc, GE Healthcare) with a 3-min scan time for stress and a 2-min scan time for rest. Clinical agreement (normal, ischaemia, scar) between CZT and SPECT was assessed for each patient and for each coronary territory using SPECT MPI as the reference standard. Segmental myocardial tracer uptake values (percent of maximum) using a 20-segment model and left ventricular ejection fraction (EF) values obtained using CZT were compared with those obtained using conventional SPECT by intraclass correlation and by calculating Bland-Altman limits of agreement. There was excellent clinical agreement between CZT and conventional SPECT on a per-patient basis (96.0%) and on a per-vessel territory basis (96.4%) as shown by a highly significant correlation between segmental tracer uptake values (r=0.901, p<0.001). Similarly, EF values for both scanners were highly correlated (r=0.976, p<0.001) with narrow Bland-Altman limits of agreement (-5.5-10.6%). The novel CZT camera allows a more than fivefold reduction in scan time and provides clinical information equivalent to conventional standard SPECT MPI. (orig.)

  2. Calibration of gamma cameras for in vivo monitoring of workers occupationally exposed to unsealed sources in nuclear medicine

    International Nuclear Information System (INIS)

    The routine manipulation of unsealed sources of various radionuclides for therapy and diagnostic in nuclear medicine poses a significant risk of internal exposure to the staff. The critical group includes workers who develop a variety of wet operations such as dose fractionation, preparation of radiopharmaceuticals and administration to the patients. The internal monitoring of such workers is recommended by the IAEA for those who might be exposed to effective doses above 1 mSv per year. According to the CNEN regulations, the Radiation Safety Officer of the facility is responsible for the selection of workers to be submitted to a routine monitoring. Currently, in Brazil, internal monitoring can only be executed in a few Laboratories located in governmental institutions, which turns unfeasible to implement such control in a national basis. On the other hand, such monitoring procedures could be carried out in the nuclear medicine services by using their image diagnose equipment. Among the radionuclides used in nuclear medicine, iodine-131 (131I) is still largely applied for diagnostic and treatment of thyroid diseases. The objective of this work is to establish a calibration protocol and an in vivo measurement procedure to evaluate incorporation of 131I using gamma cameras. The calibration factors - necessary to calculate the activity deposited in the human body - of two gamma cameras installed in University Hospitals located in the city of Rio de Janeiro were determined with a neck-thyroid phantom developed at the In Vivo Monitoring Laboratory of IRD. Both equipment presented equivalent sensitivities for in vivo measurement of 131I in thyroid. The results show that the gamma camera can be used for routine monitoring of 131I since the minimum detectable effective dose for a standard count time of 10 minutes is below 1 mSv. (author)

  3. Regional cerebral blood flow measurement using N-isopropyl-p-[123I] iodoamphetamine and rotating gamma camera emission computed tomography

    International Nuclear Information System (INIS)

    Thirty-one regional cerebral blood flow (rCBF) measurements were performed on 26 patients with cerebrovascular accidents using N-Isopropyl-p-[123I] Iodoamphetamine (123I-IMP) and rotating gamma camera emission computed tomography (ECT). The equation for determining rCBF is as follows: F=100.R.Cb/(N.A), where F is rCBF in ml/100 g/min., R is the constant withdrawal rate of arterial blood in ml/min., Cb is the brain activity concentration in μCi/g, A is the total activity (5 min.) in the withdrawal arterial whole blood in μCi and N is the fraction of A that is true tracer activity (0.75). In determining Cb at 5 min. after injection, reconstructed counts from 35 min. to 59 min. were corrected to represent those from 4 min. to 5 min. with the use of time activity curve for the entire brain immediately after injection to 30 min. Reconstructed counts of central region in tomographic image were corrected 118% of the obtained values from the result of the countingrate ratio between peripheral and central regions of interests obtained from phantom study. Brain mean blood flow values were distributed from 11 to 39 ml/100 g/min. In 119 cortical regions obtained from 11 measurements in 9 patients, there was a significant correlation (r=0.41, p123I-IMP and rotating gamma camera ECT and those from 133Xe inhalation method. rCBF measurement using 123I-IMP and rotating gamma camera ECT is not only relatively noninvasive measurement for the entire brain but also three-dimensional evaluation. Besides, it is superior in spatial resolution and accuracy to conventional 133Xe clearance method. (author)

  4. Could the eZ-SCOPE AN Gamma Camera Replace Intraoperative Measurement of iPTH for PHPT?

    OpenAIRE

    Fujii, Takaaki; Yajima, Reina; Yamaguchi, Satoru; Tsutsumi, Soichi; Asao, Takayuki; Kuwano, Hiroyuki

    2012-01-01

    Intraoperative intact parathyroid hormone (iPTH) measurements have been proposed as an effective assay in surgery for primary hyperparathyroidism (PHPT). We have demonstrated the efficiency of the use of a hand-held gamma camera, eZ-SCOPE AN, with technetium-99m sestamibi (Tc-MIBI) scintigraphy for navigation surgery for PHPT. The aim of this preliminary study was to assess the possibility that the eZ-SCOPE AN can replace the measurement of intraoperative iPTH in surgery for PHPT. Sixteen con...

  5. Inter-comparative study to evaluate the current state of gamma cameras and SPECT systems in Cuba

    International Nuclear Information System (INIS)

    The aim of this study was to perform an inter-comparative study to evaluate the current state of the gamma cameras and SPECT systems in Cuba. In situ measurements were carried out in all the nuclear medicine departments participating in the study. This work was performed as part of a global project to establish a national programme for quality control of nuclear medicine instruments. The Cuban regulatory authorities (CCEEM) participated and supported this job. Firstly, a survey was carried out in order to collect data about the features of the instruments and availability of accessories for the quality control procedures. The selected tests and procedures were based on international standards for quality control of nuclear medicine instruments. Evaluations of uniformity, spatial resolution, sensitivity, energy resolution, linearity, tomographic uniformity, center of rotation, tomographic resolution and total performance for SPECT systems were carried out in the five gamma cameras and five SPECT system available in the country. Nuclear medicine services and equipments were codified in order to maintain anonymity. Table 1 summarizes the parameters measured in all the equipment. In general, the outcome of the quality control measurements showed that most of the evaluated equipment was working in an appropriate and acceptable technical state. As a rule, the instruments with longer period of use showed higher irregularities in the evaluated parameters. Some detected problems were solved by means of corrective procedures during the measurement period; otherwise, suggestions were provided to the engineering services in order to fix them. Outcomes were recorded in a technical report and a formal information was provided to hospital authorities and the national regulatory authorities. In spite of the results showing that majority of the equipment had acceptable non-uniformity values (integral and differential) below 5% for UFOV and CFOV, two gamma cameras (PH-3) and (SH-2

  6. X-ray and gamma-ray imaging with multiple-pinhole cameras using a posteriori image synthesis.

    Science.gov (United States)

    Groh, G.; Hayat, G. S.; Stroke, G. W.

    1972-01-01

    In 1968, Dicke had suggested that multiple-pinhole camera systems would have significant advantages concerning the SNR in X-ray and gamma-ray astronomy if the multiple images could be somehow synthesized into a single image. The practical development of an image-synthesis method based on these suggestions is discussed. A formulation of the SNR gain theory which is particularly suited for dealing with the proposal by Dicke is considered. It is found that the SNR gain is by no means uniform in all X-ray astronomy applications.

  7. Development of event reconstruction algorithm for full-body gamma-camera based on SiPMs

    Science.gov (United States)

    Philippov, D. E.; Belyaev, V. N.; Buzhan, P. Zh; Ilyin, A. L.; Popova, E. V.; Stifutkin, A. A.

    2016-02-01

    The gamma-camera is the detector for nuclear medical imaging where the photomultiplier tubes (PMTs) could be replaced by the silicon photomultipliers (SiPMs). Common systems have the energy resolution about 10% and intrinsic spatial resolution about 3 mm (FWHM). In order to achieve the requirement energy and spatial resolution the classical Anger's logic should be modified. In case of a standard monolithic thallium activated sodium iodide scintillator (500x400x10 mm3) and SiPM readout it could be done with identification of the clusters. We show that this approach has a good results with the simulated data.

  8. Calibration of gamma camera systems for a multicentre European 123I-FP-CIT SPECT normal database

    International Nuclear Information System (INIS)

    A joint initiative of the European Association of Nuclear Medicine (EANM) Neuroimaging Committee and EANM Research Ltd. aimed to generate a European database of [123I]FP-CIT single photon emission computed tomography (SPECT) scans of healthy controls. This study describes the characterization and harmonization of the imaging equipment of the institutions involved. 123I SPECT images of a striatal phantom filled with striatal to background ratios between 10:1 and 1:1 were acquired on all the gamma cameras with absolute ratios measured from aliquots. The images were reconstructed by a core lab using ordered subset expectation maximization (OSEM) without corrections (NC), with attenuation correction only (AC) and additional scatter and septal penetration correction (ACSC) using the triple energy window method. A quantitative parameter, the simulated specific binding ratio (sSBR), was measured using the ''Southampton'' methodology that accounts for the partial volume effect and compared against the actual values obtained from the aliquots. Camera-specific recovery coefficients were derived from linear regression and the error of the measurements was evaluated using the coefficient of variation (COV). The relationship between measured and actual sSBRs was linear across all systems. Variability was observed between different manufacturers and, to a lesser extent, between cameras of the same type. The NC and AC measurements were found to underestimate systematically the actual sSBRs, while the ACSC measurements resulted in recovery coefficients close to 100% for all cameras (AC range 69-89%, ACSC range 87-116%). The COV improved from 46% (NC) to 32% (AC) and to 14% (ACSC) (p < 0.001). A satisfactory linear response was observed across all cameras. Quantitative measurements depend upon the characteristics of the SPECT systems and their calibration is a necessary prerequisite for data pooling. Together with accounting for partial volume, the correction for scatter and septal

  9. Evaluation of Compton gamma camera prototype based on pixelated CdTe detectors

    OpenAIRE

    Calderón, Y.; Chmeissani, M.; Kolstein, M.; De Lorenzo, G.

    2014-01-01

    A proposed Compton camera prototype based on pixelated CdTe is simulated and evaluated in order to establish its feasibility and expected performance in real laboratory tests. The system is based on module units containing a 2×4 array of square CdTe detectors of 10×10 mm2 area and 2 mm thickness. The detectors are pixelated and stacked forming a 3D detector with voxel sizes of 2 × 1 × 2 mm3. The camera performance is simulated with Geant4-based Architecture for Medicine-Oriented Simulations(G...

  10. An innovative silicon photomultiplier digitizing camera for gamma-ray astronomy

    CERN Document Server

    Heller, Matthieu; Porcelli, Alessio; Pujadas, Isaac Troyano; Zietara, Krzysztof; Della Volpe, Domenico; Montaruli, Teresa; Cadoux, Franck; Favre, Yannick; Sanchez, Juan Antonio Aguilar; Christov, Asen; Prandini, Elisa; Rajda, Pawel; Rameez, Mohamed; Blinik, Woijciech; Blocki, Jacek; Bogacz, Leszek; Borkowski, Jurek; Bulik, Tomasz; Frankowski, Adam; Grudzinska, Mira; Idzkowski, Bartosz; Jamrozy, Mateusz; Janiak, Mateusz; Kasperek, Jerzy; Lalik, Krzysztof; Lyard, Etienne; Mach, Emil; Mandat, Dusan; Marszalek, Adrian; Miranda, Luis David Medina; Michalowski, Jerzy; Neronov, Andrii; Niemiec, Jacek; Ostrowski, Michal; Pasko, Pawel; Pech, Miroslav; Schovanek, Petr; Seweryn, Karol; Sliusar, Vitalii; Skowron, Krzysztof; Stawarz, Lukasz; Stodulska, Magdalena; Stodulski, Marek; Walter, Roland; Wiecek, Marek; Zagdanski, Aleksander

    2016-01-01

    The single-mirror small-size telescope (SST-1M) is one of the three proposed designs for the small-size telescopes (SSTs) of the Cherenkov Telescope Array (CTA) project. The SST-1M will be equipped with a 4 m-diameter segmented mirror dish and an innovative fully digital camera based on silicon photo-multipliers (SiPMs). Since the SST sub-array will consist of up to 70 telescopes, the challenge is not only to build a telescope with excellent performance, but also to design it so that its components can be commissioned, assembled and tested by industry. In this paper we review the basic steps that led to the design concepts for the SST-1M camera and the ongoing realization of the first prototype, with focus on the innovative solutions adopted for the photodetector plane and the readout and trigger parts of the camera. In addition, we report on results of laboratory measurements on real scale elements that validate the camera design and show that it is capable of matching the CTA requirements of operating up to...

  11. Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

    Science.gov (United States)

    Lee, Young Sub; Kim, Jin Su; Deuk Cho, Kyung; Kang, Joo Hyun; Moo Lim, Sang

    2015-07-01

    We performed imaging and therapy using I-131 trastuzumab and a pinhole collimator attached to a conventional gamma camera for human use in a mouse model. The conventional clinical gamma camera with a 2-mm radius-sized pinhole collimator was used for monitoring the animal model after administration of I-131 trastuzumab The highest and lowest radiation-received organs were osteogenic cells (0.349 mSv/MBq) and skin (0.137 mSv/MBq), respectively. The mean coefficients of variation (%CV) of the effective dose equivalent and effective dose were 0.091 and 0.093 mSv/MBq respectively. We showed the feasibility of the pinholeattached conventional gamma camera for human use for the assessment of dosimetry. Mouse dosimetry and prediction of human dosimetry could be used to provide data for the safety and efficacy of newly developed therapeutic schemes.

  12. Tumor dosimetry for I-131 trastuzumab therapy in a Her2+ NCI N87 xenograft mouse model using the Siemens SYMBIA E gamma camera with a pinhole collimator

    International Nuclear Information System (INIS)

    We performed imaging and therapy using I-131 trastuzumab and a pinhole collimator attached to a conventional gamma camera for human use in a mouse model. The conventional clinical gamma camera with a 2-mm radius-sized pinhole collimator was used for monitoring the animal model after administration of I-131 trastuzumab The highest and lowest radiation-received organs were osteogenic cells (0.349 mSv/MBq) and skin (0.137 mSv/MBq), respectively. The mean coefficients of variation (%CV) of the effective dose equivalent and effective dose were 0.091 and 0.093 mSv/MBq respectively. We showed the feasibility of the pinholeattached conventional gamma camera for human use for the assessment of dosimetry. Mouse dosimetry and prediction of human dosimetry could be used to provide data for the safety and efficacy of newly developed therapeutic schemes

  13. Evaluation of the performance of a gamma camera equipped with a 5/8'' versus 1'' thick NaI detector

    International Nuclear Information System (INIS)

    The upgrade of a gamma camera from a 5/8'' to a 1'' thick crystal, the latter with StarBrite technology, prompted to the investigation of changes in performance parameters for planar scintigraphy and SPECT, as well as for PET in coincidence mode. For planar and SPECT parameters, the performance was measured according to NEMA standard protocol NU1-2001. No changes were found in terms of intrinsic uniformity, intrinsic spatial resolution, linearity, energy resolution, system resolution, and tomographic system resolution. The only change was an increase of system sensitivity for higher energy gamma rays. For the PET scanner in coincidence mode, the image quality of the camera was determined according lo NEMA NU2-2001. Visually and in terms of contrast values there was a significant improvement of image quality. Changes in image quality relevant for clinical use were tested by evaluation of planar patient scans acquired within a short time with two gamma cameras of the same type, different only in crystal thickness (5/8'' and 1''). No statistically significant difference was found between corresponding scans. For planar and SPECT imaging, the gamma camera with 1'' thick detector and StarBrite technology demonstrated the same performance of a camera with a 5/8'' crystal. For PET in coincidence mode the new detector proved clearly superior. (orig.)

  14. The influence of electron multiplication and internal X-ray fluorescence on the performance of a scintillator-based gamma camera

    OpenAIRE

    Hall, David; Holland, Andrew; Soman, Matthew

    2012-01-01

    When considering the "standard" gamma-camera, one might picture an array of photo-multiplier tubes or a similar array of small-area detectors. This array of imaging detectors would be attached to a corresponding array of scintillator modules (or a solid layer of scintillator) in order to give a high detection efficiency in the energy region of interest, usually 8-140 keV. Over recent years, developments of gamma-cameras capable of achieving much higher spatial resolutions have led to a new ra...

  15. SPECT in PET era: Do gamma cameras still have a role in the oncological diagnosis and management?

    International Nuclear Information System (INIS)

    In a Nuclear Medicine Department, usually 50-60% of the gamma camera studies are performed to stratify oncological patients or their follow-up. Planar and SPECT studies are more affordable for the social security budget in Latin America than those from PET. Cost of nuclear medicine non-PET studies are in the range of $150-200, while a PET is nearly $1500-1800. Moreover, the large armamentarium of radiopharmaceutical compounds available for the gamma cameras, with specific labelled antibodies turn the mentioned instrument in a more versatile tool than PET. QC of the radiopharmaceutical, the gamma camera (planar and Spect) performance and protocol of the study should be strictly kept to obtain a reliable set of images. If the former are followed the study will be still incorporated in the diagnostic algorithm of the oncological patient. Consideration must also be taken in account that although more PET centers are being built, few have the baby cyclotron capacity that will allow the use of other compounds than FDG-F I S. Expertise training is not fully achieved. Aim: To show the important role that the gamma camera studies still have in the diagnostic algorithm of the oncological patient. Materials and Methods: We led a retrospectively analysis of the last five years of patients consulting in our general Nuclear Medicine Department (with planar and Spect facility). Our Nuclear Medicine Center is a representative General Clinical University Center, in a 500 bed Hospital situated in the Capital City of Argentina (with a population of 11.000.000 inhabitants). Fifteen-thousand (15.000) patients were evaluated in these five years. The study demand was in decreasing order as follows: bone scintigraphy, diagnostic and therapeutic thyroid studies, cardiological pathologies, pulmonary studies, renal investigation, infectious diseases, ontological gallium, mamoscintigraphy, gastroenterological scans, sentinel node, radiosinovectomies, octreotride-In-111, MIBG-1-13 I, bone pain

  16. F-18-FDG positron imaging in oncological patients: gamma camera coincidence detection versus dedicated PET

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M.; Kaiser, H.J.; Cremerius, U.; Sabri, O.; Schreckenberger, M.; Reinartz, P.; Buell, U. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin

    1999-08-01

    Aim of the present study was to investigate the feasibility of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) imaging in oncological patients with a dual head gamma camera modified for coincidence detection (MCD). Methods: Phantom studies were done to determine lesion detection at various lesion-to-background ratios, system sensitivity and spatial resolution. Thirty-two patients with suspected or known malignant disease were first studied with a dedicated full-ring PET system (DPET) applying measured attenuation correction and subsequently with an MCD system without attenuation correction. MCD images were first interpreted without knowledge of the DPET findings. In a second reading, MCD and DPET were evaluated simultaneously. Results: The phantom studies revealed a comparable spatial resolution for DPET and MCD (5.9 x 6.3 x 4.2 mm vs. 5.9 x 6.5 x 6.0 mm). System sensitivity of MCD was less compared to DPET (91 cps/Bq/ml/cm{sub FOV} vs. 231 cps/Bq/ml/cm{sub FOV}). At a lesion-to-background ratio of 4:1, DPET depicted a minimal phantom lesion of 1.0 cm in diameter, MCD a minimal lesion of 1.6 cm. With DPET, a total of 91 lesions in 27 patients were classified as malignant. MCD without knowledge of DPET results revealed increased FDG uptake in all patients with positive DPET findings. MCD detected 72 out of 91 DPET lesions (79.1%). With knowledge of the DPET findings, 11 additional lesions were detected (+12%). MCD missed lesions in six patients with relevance for staging in two patients. All lesions with a diameter above 18 mm were detected. Conclusion: MCD FDG imaging yielded results comparable to dedicated PET in most patients. However, a considerable number of small lesions clearly detectable with DPET were not detected by MCD alone. Therefore, MCD cannot yet replace dedicated PET in all oncological FDG studies. Further technical refinement of this new method is needed to improve imaging quality (e.g. attenuation correction). (orig.) [Deutsch] Ziel dieser Studie

  17. SU-C-201-07: Validation of a GATE Gamma Camera Model for the Siemens Symbia

    Energy Technology Data Exchange (ETDEWEB)

    Mikell, J; Siman, W; Kappadath, S [Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX (United States); Mourtada, F [Christiana Care Hospital, Newark, DE (United States); Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston TX (United States); Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)

    2015-06-15

    Purpose: To develop a simulation model of a clinical gamma camera/SPECT system and to validate the model using experimental and published measurements from the clinical system. Methods: Geant4 Application for Tomographic Emission (GATE) was used to create a model of the Siemens Symbia gamma camera. A modular model was implemented that allows specifying combinations of crystal thickness (3/8”, 5/8”) and collimator (LEHR, MELP, HE). Shielding, energy resolution, intrinsic resolution, crystal thickness, and collimator properties were set based on manufacturer specifications. Validation of the model was performed by simulating NEMA 2007 gamma camera tests including spatial resolution and sensitivity for Tc99; these were compared with experimental and published data for the scanner. The simulated energy spectra of a Tc99 line source in acrylic blocks was visually compared with the corresponding experimental acquisition. For a 4 cm diameter sphere filled with Tc99, the attenuation maps were generated from simulation data, and the photopeak and scatter window were extracted from GATE output using ROOT to create DICOM files to use in the clinical reconstruction. Results: Simulated spatial resolutions for LEHR 3/8” crystal at 0, 10 cm, 10 cm (with scatter), and 30 cm were 4, 6.7, 7.9, and 14.5 mm FWHM; these were 9% less than published data. For 5/8” crystal the spatial resolutions were 4.5, 7.0, 8.5, and 14.7 mm FWHM; these were 4% to 10% less than published data. Simulated sensitivity was within 3.5% of published data for both LEHR 3/8” and 5/8”. The simulated energy spectra matched the photopeak and scatter window well, but did overestimate the counts below 90 keV. The simulated attenuation map and projection data were successfully reconstructed with the clinical software, and the passed visual inspection. Conclusions: Validation of a specific clinical scanner allows future studies of quantification accuracy for both planar and SPECT imaging. Research

  18. {sup 18F}-FDG PET imaging with dual head gamma camera and co-incidence detection

    Energy Technology Data Exchange (ETDEWEB)

    Quach, T.; Camden, B.M.; Chu, J.M.G. [Liverpool Health Services, Liverpool, NSW (Australia). Department of Nuclear Medicine and Clinical Ultrasound

    1998-06-01

    Full text: {sup 18F}-Fluorodeoxyglucose (FDG) positron tomography is based on the detection of two 511 keV photons which are produced 180 deg apart as a result of an annihilation of a positron and an electron. Apart from the dedicated PET scanner, dual head gamma camera designed for Co-incidence Detection (CD) can now perform `{sup 18}F-FDG PET studies. CD imaging involves using a dual head gamma camera to detect those photons which are 180 deg apart and fall within a timing window of 15 nsec. No collimators are required as a timing gate of 15 nsec is used. {sup 18}F-FDG studies are performed using an ADAC Solus Molecular Co-incidence Detection (MCD) dual head gamma camera. The patients are fasted from midnight but well hydrated before the scan. Prior to injection, the blood sugar levels (BSL) are measured. For optimal {sup 18}F-FDG uptake, the BSL should be less than 8.9 mmol/L. A dose of 200MBq of {sup 18}F-FDG is intravenously injected via a cannula. Scanning commences at 1 hour post injection. To perform a wholebody tomography of the torso, the patient must void before scanning to reduce bladder activity. Excessive bladder activity leads to significant image degradation, therefore the wholebody tomography is started from the pelvis. Depending on the patient torso length, either 2 or 3 tomographies are collected with a 50% overlap. Each tomography is collected for 40 seconds per step for 32 steps. To avoid attenuation from the upper limbs, the patient is positioned supine with the arms above the head. If a patient cannot tolerate this position, scanning with the arms by the side may be necessary since the scanning time may take up to 50 minutes. If the area of interest is the neck, scanning with the patient`s arms down by their sides is preferred, although attenuation will occur. To scan the brain, a circular tomography is performed using 32 steps at 80 seconds per step. For processing purposes, the Singles count rate for each detector must be between 800K and

  19. [F18]-FDG imaging of experimental animal tumours using a hybrid gamma-camera

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) has been widely used in clinical studies. This technology permits detection of compounds labelled with positron emitting radionuclides and in particular, [F18]-fluorodeoxyglucose ([F18]-FDG).[F18]-FDG uptake and accumulation is generally related to malignancy; some recent works have suggested the usefulness of PET camera dedicated to small laboratory animals (micro-PET). Our study dealt with the feasibility of [F18]-FDG imaging of malignant tumours in animal models by means of an hybrid camera dedicated for human scintigraphy. We evaluated the ability of coincidence detection emission tomography (CDET) using this hybrid camera to visualize in vivo subcutaneous tumours grafted to mice or rats. P815 murine mastocytoma grafted in syngeneic DBA/2 mice resulted with foci of very high FDG uptake. Tumours with a diameter of only 3 mm were clearly visualized. Medullary thyroid cancer provoked by rMTC 6/23 and CA77 lines in syngeneic Wag/Rij rat was also detected. The differentiated CA77 tumours exhibited avidity for [F18]-FDG and a tumour, which was just palpable (diameter lower than 2 mm), was identified. In conclusion, CDET-FDG is a non-invasive imaging tool which can be used to follow grafted tumours in the small laboratory animal, even when their size is smaller than 1 cm. It has the potential to evaluate experimental anticancer treatments in small series of animals by individual follow-up. It offers the opportunity to develop experimental PET research within a nuclear medicine or biophysics department, the shift to a dedicated micro-PET device being subsequently necessary. It is indeed compulsory to strictly follow the rules for non contamination and disinfection of the hybrid camera. (authors)

  20. Evaluation of Compton gamma camera prototype based on pixelated CdTe detectors.

    Science.gov (United States)

    Calderón, Y; Chmeissani, M; Kolstein, M; De Lorenzo, G

    2014-06-01

    A proposed Compton camera prototype based on pixelated CdTe is simulated and evaluated in order to establish its feasibility and expected performance in real laboratory tests. The system is based on module units containing a 2×4 array of square CdTe detectors of 10×10 mm(2) area and 2 mm thickness. The detectors are pixelated and stacked forming a 3D detector with voxel sizes of 2 × 1 × 2 mm(3). The camera performance is simulated with Geant4-based Architecture for Medicine-Oriented Simulations(GAMOS) and the Origin Ensemble(OE) algorithm is used for the image reconstruction. The simulation shows that the camera can operate with up to 10(4) Bq source activities with equal efficiency and is completely saturated at 10(9) Bq. The efficiency of the system is evaluated using a simulated (18) F point source phantom in the center of the Field-of-View (FOV) achieving an intrinsic efficiency of 0.4 counts per second per kilobecquerel. The spatial resolution measured from the point spread function (PSF) shows a FWHM of 1.5 mm along the direction perpendicular to the scatterer, making it possible to distinguish two points at 3 mm separation with a peak-to-valley ratio of 8. PMID:24932209

  1. Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera

    International Nuclear Information System (INIS)

    Prompt-gamma profile was measured at WPE-Essen using 160 MeV protons impinging a movable PMMA target. A single collimated detector was used with time-of-flight (TOF) to reduce the background due to neutrons. The target entrance rise and the Bragg peak falloff retrieval precision was determined as a function of incident proton number by a fitting procedure using independent data sets. Assuming improved sensitivity of this camera design by using a greater number of detectors, retrieval precisions of 1 to 2 mm (rms) are expected for a clinical pencil beam. TOF improves the contrast-to-noise ratio and the performance of the method significantly. (paper)

  2. Gamma-camera functional scintigraphy for the differential diagnosis of the morbus Basedow: Results of 423 patients

    International Nuclear Information System (INIS)

    The functional scintigraphy with Tc-99m pertechnate and a computerized gamma-camera system allows not only the determination of 99mTcO4- uptake (TcTU) as a functional parameter of the thyroid turnover, but also of the functional mass as an additional parameter. This parameter is determined in all our studies, and also for investigation of the autoimmunity-induced hyperthyreosis, in addition to the TSH-receptor auto-antibodies. Thyroid stimulating or blocking immunoglobulins or thyroid growth stimulating immunoglobulins are measured with commercially available kits. The contribution at hand considers the results of the 99mTc-uptakes: The data are used for quantifying the extrinsic stimulation of the TSH receptor in morbus Basedow patients in comparison with normal test persons and other thyroid malfunctions. (orig./SHA)

  3. Performance improvement of small gamma camera using NaI(Tl) plate and position sensitive photo-multiplier tubes

    International Nuclear Information System (INIS)

    The purpose of this study was to improve the performance of a small gamma camera, utilizing a NaI(Tl) plate and a 5'' position sensitive PMT. We attempted to build a NaI(Tl) plate crystal system which retained all its advantages, while at the same time integrating some of the advantages inherent in an array-type scintillation crystal system. Flood images were obtained with a lead hole mask, and position mapping was performed by detecting hole positions in the flood image. Energy calibration was performed using the energy spectra obtained from each hole position. Flood correction was performed using a uniformity correction table containing the relative efficiency of each image element. The spatial resolution was improved about 16% after correction at the centre field of view. Resolution deterioration at the outer field of view (OFOV) was considerably ameliorated, from 6.7 mm to 3.2 mm after correction. The sensitivity at the OFOV was also increased after correction, from 0.7 cps μCi-1 to 2.0 cps μCi-1. The correction also improved uniformity, from 5.2% to 2.1%, and linearity, from 0.5 mm to 0 mm. The results of this study indicate that the revised correction method can be employed to considerably improve the performance of a small gamma camera using a NaI(Tl) plate-type crystal. This method also provides high spatial resolution and linearity, like array-type crystals do, while retaining the specific advantages of plate-type crystals

  4. Gamma-ray detection and Compton camera image reconstruction with application to hadron therapy

    International Nuclear Information System (INIS)

    A novel technique for radiotherapy - hadron therapy - irradiates tumors using a beam of protons or carbon ions. Hadron therapy is an effective technique for cancer treatment, since it enables accurate dose deposition due to the existence of a Bragg peak at the end of particles range. Precise knowledge of the fall-off position of the dose with millimeters accuracy is critical since hadron therapy proved its efficiency in case of tumors which are deep-seated, close to vital organs, or radio-resistant. A major challenge for hadron therapy is the quality assurance of dose delivery during irradiation. Current systems applying positron emission tomography (PET) technologies exploit gamma rays from the annihilation of positrons emitted during the beta decay of radioactive isotopes. However, the generated PET images allow only post-therapy information about the deposed dose. In addition, they are not in direct coincidence with the Bragg peak. A solution is to image the complete spectrum of the emitted gamma rays, including nuclear gamma rays emitted by inelastic interactions of hadrons to generated nuclei. This emission is isotropic, and has a spectrum ranging from 100 keV up to 20 MeV. However, the measurement of these energetic gamma rays from nuclear reactions exceeds the capability of all existing medical imaging systems. An advanced Compton scattering detection method with electron tracking capability is proposed, and modeled to reconstruct the high-energy gamma-ray events. This Compton detection technique was initially developed to observe gamma rays for astrophysical purposes. A device illustrating the method was designed and adapted to Hadron Therapy Imaging (HTI). It consists of two main sub-systems: a tracker where Compton recoiled electrons are measured, and a calorimeter where the scattered gamma rays are absorbed via the photoelectric effect. Considering a hadron therapy scenario, the analysis of generated data was performed, passing trough the complete

  5. Clinical value of F -18 Fag dual-head gamma camera coincidence imaging in patients with high-risk melanoma

    International Nuclear Information System (INIS)

    Tumour detection based on the uptake of F-18 FDG has been successfully used in the diagnosis of melanoma. We retrospectively evaluated the clinical value of dual-head gamma-camera coincidence PET imaging in patients with high-risk melanoma sent to the Institute of Nuclear Medicine at the General Hospital Linz between 19982002. The cohort included 33 persons (12 women), mean age was 54+ 17 yrs. Median time since first surgery confirming the diagnosis was 24 months (quartiles 2; 54) and after last extirpation of malignant tissue had passed 2 months (quartiles 1; 12). Assessment of diagnostic findings was confirmed by either histological verification or sequel control examination. Calculated on a patient basis, prevalence was 45%. Coincidence PET data was compared to the cumulative information provided by conventional radiological imaging (CT, ultrasound, X-ray) and presented superior values in sensitivity (80% vs. 73%), specificity (89% vs. 56%), positive predictive value (86% vs. 58%) and negative predictive value (84% vs. 71%).It was concluded that under conditions of limited availability of dedicated PET camera systems, the use of coincidence PET systems in patients with high risk melanoma can be recommended as it provides valuable information for clinical practice. (author)

  6. Simulation-based evaluation and optimization of a new CdZnTe gamma-camera architecture (HiSens)

    International Nuclear Information System (INIS)

    A new gamma-camera architecture named HiSens is presented and evaluated. It consists of a parallel hole collimator, a pixelated CdZnTe (CZT) detector associated with specific electronics for 3D localization and dedicated reconstruction algorithms. To gain in efficiency, a high aperture collimator is used. The spatial resolution is preserved thanks to accurate 3D localization of the interactions inside the detector based on a fine sampling of the CZT detector and on the depth of interaction information. The performance of this architecture is characterized using Monte Carlo simulations in both planar and tomographic modes. Detective quantum efficiency (DQE) computations are then used to optimize the collimator aperture. In planar mode, the simulations show that the fine CZT detector pixelization increases the system sensitivity by 2 compared to a standard Anger camera without loss in spatial resolution. These results are then validated against experimental data. In SPECT, Monte Carlo simulations confirm the merits of the HiSens architecture observed in planar imaging.

  7. Simulation-based evaluation and optimization of a new CdZnTe gamma-camera architecture (HiSens)

    Energy Technology Data Exchange (ETDEWEB)

    Robert, Charlotte; Montemont, Guillaume; Rebuffel, Veronique; Guerin, Lucie; Verger, Loick [CEA, LETI, MINATEC, F38054 Grenoble (France); Buvat, Irene [IMNC-UMR 8165 CNRS, Universites Paris 7 et Paris 11, Bat 104, 91406 Orsay (France)

    2010-05-07

    A new gamma-camera architecture named HiSens is presented and evaluated. It consists of a parallel hole collimator, a pixelated CdZnTe (CZT) detector associated with specific electronics for 3D localization and dedicated reconstruction algorithms. To gain in efficiency, a high aperture collimator is used. The spatial resolution is preserved thanks to accurate 3D localization of the interactions inside the detector based on a fine sampling of the CZT detector and on the depth of interaction information. The performance of this architecture is characterized using Monte Carlo simulations in both planar and tomographic modes. Detective quantum efficiency (DQE) computations are then used to optimize the collimator aperture. In planar mode, the simulations show that the fine CZT detector pixelization increases the system sensitivity by 2 compared to a standard Anger camera without loss in spatial resolution. These results are then validated against experimental data. In SPECT, Monte Carlo simulations confirm the merits of the HiSens architecture observed in planar imaging.

  8. Simulation-based evaluation and optimization of a new CdZnTe gamma-camera architecture (HiSens)

    Science.gov (United States)

    Robert, Charlotte; Montémont, Guillaume; Rebuffel, Véronique; Buvat, Irène; Guérin, Lucie; Verger, Loïck

    2010-05-01

    A new gamma-camera architecture named HiSens is presented and evaluated. It consists of a parallel hole collimator, a pixelated CdZnTe (CZT) detector associated with specific electronics for 3D localization and dedicated reconstruction algorithms. To gain in efficiency, a high aperture collimator is used. The spatial resolution is preserved thanks to accurate 3D localization of the interactions inside the detector based on a fine sampling of the CZT detector and on the depth of interaction information. The performance of this architecture is characterized using Monte Carlo simulations in both planar and tomographic modes. Detective quantum efficiency (DQE) computations are then used to optimize the collimator aperture. In planar mode, the simulations show that the fine CZT detector pixelization increases the system sensitivity by 2 compared to a standard Anger camera without loss in spatial resolution. These results are then validated against experimental data. In SPECT, Monte Carlo simulations confirm the merits of the HiSens architecture observed in planar imaging.

  9. Multi-modality imaging using a handheld gamma camera and MRI for tumor localization

    Science.gov (United States)

    Dika, Cheryl; Georgian-Smith, Dianne

    2015-03-01

    While the methods for diagnostic and screening imaging for breast cancer are numerous, each method has its limitations. Multimodality imaging has increasingly been shown to improve the effectiveness of these imaging. Imaging of dense breast tissue has its own set of challenges. Combining MR and gamma for imaging of breast lesions may increase the sensitivity and specificity in theory especially with dense breasts. This experiment was designed as a proof-of-concept for combining MR and gamma images in a pre-clinical setting using an ex vivo bovine tissue model. Keeping the tissue in the same orientation for both imaging modalities was deemed important to increase accuracy. Using the information of the combined images could assist with localization for biopsy.

  10. Gamma camera scintillator and gamma camera

    International Nuclear Information System (INIS)

    The integrated collimator/scintillator assembly contains a collimator field set coated with a galvanic silver layer. The cell channels are partly filled with BaFCl: Eu which is suspended in a mixture of vinyl toluol and vinyl naphthene adapted to the refraction coefficient. The mixture serves as a wavelength transformation material. The side of scintillator material exposed to the incident X-radiation has got a thin reflecting Ag coating. (DG)

  11. Imaging system for cardiac planar imaging using a dedicated dual-head gamma camera

    Science.gov (United States)

    Majewski, Stanislaw; Umeno, Marc M.

    2011-09-13

    A cardiac imaging system employing dual gamma imaging heads co-registered with one another to provide two dynamic simultaneous views of the heart sector of a patient torso. A first gamma imaging head is positioned in a first orientation with respect to the heart sector and a second gamma imaging head is positioned in a second orientation with respect to the heart sector. An adjustment arrangement is capable of adjusting the distance between the separate imaging heads and the angle between the heads. With the angle between the imaging heads set to 180 degrees and operating in a range of 140-159 keV and at a rate of up to 500kHz, the imaging heads are co-registered to produce simultaneous dynamic recording of two stereotactic views of the heart. The use of co-registered imaging heads maximizes the uniformity of detection sensitivity of blood flow in and around the heart over the whole heart volume and minimizes radiation absorption effects. A normalization/image fusion technique is implemented pixel-by-corresponding pixel to increase signal for any cardiac region viewed in two images obtained from the two opposed detector heads for the same time bin. The imaging system is capable of producing enhanced first pass studies, bloodpool studies including planar, gated and non-gated EKG studies, planar EKG perfusion studies, and planar hot spot imaging.

  12. Rotating conventional gamma camera single-photon tomographic system: physical characterization

    International Nuclear Information System (INIS)

    A whole-body single-photon emission computed tomography system has been evaluated in terms of its physical performance. It consists of a standard GE 400 T maxi camera rotating on a ring stand, coupled to an Informatek Simis 3 computer system. In its standard mode of operation, 64 or 128 successive views of 64 X 64 or 128 X 64 matrices are collected at regular angular samples. The reconstruction of up to 64 possible adjacent transverse sections, sorted into coronal, sagittal, and oblique sections, is obtained by filtered backprojection. A conventional parallel-hole collimator is used. The uniformity of the camera field of view is corrected by the GE hardware module. The resolution in the transverse plane is typically of 15.5 mm in a 20 cm Lucite phantom, and independent of radial distance. The physical slice thickness is 19 mm (full width at half maximum of the longitudinal response using a point source) with only slight variations along the diameter of the image. The sensitivity is approximately 7,000 cps mCi-1 as measured using a 99m Tc thin source, enabling images of reasonable signal-to-noise ratio to be obtained in 10 min. The effect of the energy window, the number of angular samples, and the linear sampling modes on the transverse resolution and contrast is measured and discussed

  13. Effect of different thickness of material filter on Tc-99m spectra and performance parameters of gamma camera

    International Nuclear Information System (INIS)

    This study aimed to investigate the effects of material filter technique on Tc-99m spectra and performance parameters of Philip ADAC forte dual head gamma camera. Thickness of material filter was selected on the basis of percentage attenuation of various gamma ray energies by different thicknesses of zinc material. A cylindrical source tank of NEMA single photon emission computed tomography (SPECT) Triple Line Source Phantom filled with water and Tc-99m radionuclide injected was used for spectra, uniformity and sensitivity measurements. Vinyl plastic tube was used as a line source for spatial resolution. Images for uniformity were reconstructed by filtered back projection method. Butterworth filter of order 5 and cut off frequency 0.35 cycles/cm was selected. Chang's attenuation correction method was applied by selecting 0.13/cm linear attenuation coefficient. Count rate was decreased with material filter from the compton region of Tc-99m energy spectrum, also from the photopeak region. Spatial resolution was improved. However, uniformity of tomographic image was equivocal, and system volume sensitivity was reduced by material filter. Material filter improved system's spatial resolution. Therefore, the technique may be used for phantom studies to improve the image quality

  14. Effect of different thickness of material filter on Tc-99m spectra and performance parameters of gamma camera

    Science.gov (United States)

    Nazifah, A.; Norhanna, S.; Shah, S. I.; Zakaria, A.

    2014-11-01

    This study aimed to investigate the effects of material filter technique on Tc-99m spectra and performance parameters of Philip ADAC forte dual head gamma camera. Thickness of material filter was selected on the basis of percentage attenuation of various gamma ray energies by different thicknesses of zinc material. A cylindrical source tank of NEMA single photon emission computed tomography (SPECT) Triple Line Source Phantom filled with water and Tc-99m radionuclide injected was used for spectra, uniformity and sensitivity measurements. Vinyl plastic tube was used as a line source for spatial resolution. Images for uniformity were reconstructed by filtered back projection method. Butterworth filter of order 5 and cut off frequency 0.35 cycles/cm was selected. Chang's attenuation correction method was applied by selecting 0.13/cm linear attenuation coefficient. Count rate was decreased with material filter from the compton region of Tc-99m energy spectrum, also from the photopeak region. Spatial resolution was improved. However, uniformity of tomographic image was equivocal, and system volume sensitivity was reduced by material filter. Material filter improved system's spatial resolution. Therefore, the technique may be used for phantom studies to improve the image quality.

  15. Contribution to the development of a gamma radiation camera for use in scintigraphy

    International Nuclear Information System (INIS)

    This report constitutes an attempt to study systematically the properties of the detection head of a multichannel collimating grid camera. The object has been to show the disadvantages of present equipment, and to propose possible solutions for overcoming them: firstly by improving the methods used for collecting data, and the performances of the equipment doing the collecting; secondly by devising methods for processing the data so as to reduce image distortion and, first of all, the astigmatism due to the collimator. The first part deals with the study of the formation of the image by means of the collimating grid, the second with the examination of many systems which could be used for acquiring data. The last part summarizes the experiments carried out and proposes an experimental programme for the development of a prototype. (author)

  16. Development of a prototype gamma camera (Aladin) for use in decommissioning nuclear facilities

    International Nuclear Information System (INIS)

    Mapping the gamma activity of irradiating zones is often an important prerequisite in dismantling nuclear facilities. This operation is necessary to define a suitable decommissioning strategy before any work begins; it is also required during the procedure to measure the residual activity wherever dose rates are too high to allow human intervention. This paper summarizes the work carried out develop a prototype imaging system designed to display radioactive sources superimposed in real time over a visible light image on a video monitor. This project was developed from an earlier off-line system. (authors). 8 refs., 7 figs., 3 tabs

  17. Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

    International Nuclear Information System (INIS)

    Several applications in nuclear medicine require absolute activity quantification of single photon emission computed tomography images. Obtaining a repeatable calibration factor that converts voxel values to activity units is essential for these applications. Because source preparation and measurement of the source activity using a radionuclide activity meter are potential sources of variability, this work investigated instrumentation and acquisition factors affecting repeatability using planar acquisition of sealed sources. The calibration factor was calculated for different acquisition and geometry conditions to evaluate the effect of the source size, lateral position of the source in the camera field-of-view (FOV), source-to-camera distance (SCD), and variability over time using sealed Ba-133 sources. A small region of interest (ROI) based on the source dimensions and collimator resolution was investigated to decrease the background effect. A statistical analysis with a mixed-effects model was used to evaluate quantitatively the effect of each variable on the global calibration factor variability. A variation of 1 cm in the measurement of the SCD from the assumed distance of 17 cm led to a variation of 1–2% in the calibration factor measurement using a small disc source (0.4 cm diameter) and less than 1% with a larger rod source (2.9 cm diameter). The lateral position of the source in the FOV and the variability over time had small impacts on calibration factor variability. The residual error component was well estimated by Poisson noise. Repeatability of better than 1% in a calibration factor measurement using a planar acquisition of a sealed source can be reasonably achieved. The best reproducibility was obtained with the largest source with a count rate much higher than the average background in the ROI, and when the SCD was positioned within 5 mm of the desired position. In this case, calibration source variability was limited by the quantum

  18. Emission computed tomography using rotating gamma cameras for stress 201Tl myocardial imaging

    International Nuclear Information System (INIS)

    The purpose of this study is to evaluate the efficacy of emission computed tomography (ECT) for stress 201Tl myocardial imaging to localize coronary artery disease (CAD) in comparison with planar (PL) images. In a series of 14 normal subjects and 53 patients with CAD proved coronary arteriography, ECT and PL imaging were performed successively. ECT data were collected for 90 projections in a 64 x 64 matrix form with a total aquisition time of 6 munutes over 1800 of opposed dual cameras ratation and tomographic sections oriented perpendicular and parallel to the long axis of left ventricle were reconstructed. PL images were obtained for left lateral, left anterior oblique (300 and 450) and anterior projections. Both ECT and PL myocardial images were divided into 8 segments and segmental analysis was performed by visual interpretation. The ECT images remarkably increased sensitivity over the PL images in left anterior descending (LAD) artery (from 56% to 76%), right coronary artery (RCA) (from 50% to 96%), and circumflex artery (CX) (from 56% to 69%) lesions. The specificity for ECT images, as compared with PL images, was higher in LAD (88% against 85%) but slightly lower in RCA (70% ag ainst 72%) and CX (84% against 88%). Overall accuracy, therefore, was improved in LAD (from 67% to 81%) and RCA (from 64% to 79%) but equal in CX (81%). We conclude that stress 201Tl ECT imaging result in a remarkable improvement in the localization of CAD, especially in patients with RCA lesions and multi-vessel disease. (author)

  19. Design and development of pixel size calibration phantom for gamma camera

    International Nuclear Information System (INIS)

    The purpose of the study is to make pixel calibration phantom, to measure pixel size for different zoom factors and matrix sizes and to compare the pixel size with the values of provided by the vendor. For this purpose pixel size calibration phantom (rectangular in shape) made up of acrylic material having dimension 43 x 10 square cm was prepared. Seven circular holes at exact known distance with whole diameter 1.5 mm were born. High specific activity was filled in the holes of the phantom, acquired the image by fixing the number of counts at all available matrices and zoom factors. Pixel size was calculated by counting the number of pixels between focused points and divided the distance thereof by the number of pixels. Mean pixel size was calculated and compared it with reference value provided by the manufacturer of the camera. P- value was calculated which showed that most results lie in the acceptable limit. The calculated values agreed very well. However there exist some deviation at larger matrix sizes, which might be due to scattering of radiation that overlaps nearest pixels, and due to human error. (author)

  20. Design and implementation of a quality assurance program for gamma cameras; Diseno e implementacion de un programa de aseguramiento de calidad para camaras gamma

    Energy Technology Data Exchange (ETDEWEB)

    Montoya M, A.; Rodriguez L, A. [Instituto Nacional de Cancerologia, Departamento de Medicina Nuclear, Av. San Fernando No. 22, Col. Seccion XVI, 14080 Mexico D. F. (Mexico); Trujillo Z, F. E., E-mail: montoya-moreno@hotmail.co [Hospital Regional de Alta Especialidad de Oaxaca, Area de Fisica Medica, Aldama s/n, Paraje El Tule, 71256 San Bartolo Coyotepec, Oaxaca (Mexico)

    2010-09-15

    In nuclear medicine more than 90% of the carried out procedures are diagnostic. To assure an appropriate diagnostic quality of the images and the doses optimization received by the patients originated in the radioactive material, it is indispensable the periodic surveillance of the operation and performance of the equipment s by means of quality assurance tests. This work presents a proposal of a quality assurance program for gamma cameras based on recommendations of the IAEA, the American Association of Medical Physics and the National Electrical Manufacturers Association. Some tests of the program were applied to an e.cam gamma camera (Siemens) of the Nuclear Medicine Department of the National Institute of Cancer. The intrinsic and extrinsic uniformity, the intrinsic spatial resolution and the extrinsic sensibility were verified. For intrinsic uniformity the average daily values of the integral uniformity and differential uniformity in the useful vision field were 2.61% and 1.58% respectively, the average monthly values of intrinsic uniformity for the integral and differential uniformity in the useful vision field were 4.10% and 1.66% respectively. The used acceptance criterions were respectively of 3.74% and 2.74%. The average values of extrinsic uniformity for the useful vision field were of 7.65% (intrinsic uniformity) and 2.69% (extrinsic uniformity), in this case the acceptance criterion is a value of 6.00%. The average value of intrinsic spatial resolution went 4.67 mm superior to 4.4. mm that is the acceptance limit. Finally, maximum variations of 1.8% were observed (minors than 2% that is the acceptance criterion) for the extrinsic sensibility measured in different regions of the detector. Significant variations of extrinsic sensibility were not observed among the monthly lectures. Of the realized measurements was concluded that the system requires of a maintenance service by part of the manufacturer, which one carries out later on to this work. The

  1. New readout and data-acquisition system in an Electron-Tracking Compton Camera for MeV Gamma-Ray Astronomy (SMILE-II)

    CERN Document Server

    Mizumoto, Tetsuya; Mizumura, Yoshitaka; Tanimori, Toru; Kubo, Hidetoshi; Takada, Atsushi; Iwaki, Satoru; Sawano, Tatsuya; Nakamura, Kiseki; Komura, Shotaro; Nakamura, Shogo; Kishimoto, Tetsuro; Oda, Makoto; Miyamoto, Shohei; Takemura, Taito; Parker, Joseph D; Tomono, Dai; Sonoda, Shinya; Miuchi, Kentaro; Kurosawa, Shunsuke

    2015-01-01

    For MeV gamma-ray astronomy, we have developed an electron-tracking Compton camera (ETCC) as a MeV gamma-ray telescope capable of rejecting the radiation background and attaining the high sensitivity of near 1 mCrab in space. Our ETCC comprises a gaseous time-projection chamber (TPC) with a micro pattern gas detector for tracking recoil electrons and a position-sensitive scintillation camera for detecting scattered gamma rays. After the success of a first balloon experiment in 2006 with a small ETCC (using a 10$\\times$10$\\times$15 cm$^3$ TPC) for measuring diffuse cosmic and atmospheric sub-MeV gamma rays (Sub-MeV gamma-ray Imaging Loaded-on-balloon Experiment I; SMILE-I), a (30 cm)$^{3}$ medium-sized ETCC was developed to measure MeV gamma-ray spectra from celestial sources, such as the Crab Nebula, with single-day balloon flights (SMILE-II). To achieve this goal, a 100-times-larger detection area compared with that of SMILE-I is required without changing the weight or power consumption of the detector syste...

  2. Performance evaluation of a small CZT pixelated semiconductor gamma camera system with a newly designed stack-up parallel-hole collimator

    International Nuclear Information System (INIS)

    Gamma ray imaging techniques that use a cadmium zinc telluride (CZT) or cadmium telluride (CdTe) pixelated semiconductor detectors have rapidly gained popularity as a key tool for nuclear medicine research. By using a pinhole collimator with a pixelated semiconductor gamma camera system, better spatial resolution can be achieved. However, this improvement in spatial resolution is accomplished with a decrease in the sensitivity due to the small collimator hole diameter. Furthermore, few studies have been conducted for novel parallel-hole collimator geometric designs with pixelated semiconductor gamma camera systems. A gamma camera system which combines a CZT pixelated semiconductor detector with a newly designed stack-up parallel-hole collimator was developed and evaluated. The eValuator-2500 CZT pixelated semiconductor detector (eV product, Saxonburg, PA) was selected for the gamma camera system. This detector consisted of a row of four CZT crystals of 12.8 mm in length with 3 mm in thickness. The proposed parallel-hole collimator consists of two layers. The upper layer results in a fourfold increase in hole size compared to a matched square hole parallel-hole collimator with an equal hole and pixel size, while the lower layer also consisted of fourfold holes size and pretty acts as a matched square hole parallel-hole collimator. The overlap ratios of these collimators were 1:1, 1:2, 2:1, 1:5, and 5:1. These collimators were mounted on the eValuator-2500 CZT pixelated semiconductor detector. The basic performance of the imaging system was measured for a 57Co gamma source (122 keV). The measured averages of sensitivity and spatial resolution varied depending on the overlap ratios of the proposed parallel-hole collimator and source-to-collimator distances. One advantage of our system is the use of stacked collimators that can select the best combination of system sensitivity and spatial resolution. With low counts, we can select a high sensitivity collimator with a 1

  3. Performance evaluation of a small CZT pixelated semiconductor gamma camera system with a newly designed stack-up parallel-hole collimator

    Science.gov (United States)

    Lee, Youngjin; Kim, Hee-Joung

    2015-09-01

    Gamma ray imaging techniques that use a cadmium zinc telluride (CZT) or cadmium telluride (CdTe) pixelated semiconductor detectors have rapidly gained popularity as a key tool for nuclear medicine research. By using a pinhole collimator with a pixelated semiconductor gamma camera system, better spatial resolution can be achieved. However, this improvement in spatial resolution is accomplished with a decrease in the sensitivity due to the small collimator hole diameter. Furthermore, few studies have been conducted for novel parallel-hole collimator geometric designs with pixelated semiconductor gamma camera systems. A gamma camera system which combines a CZT pixelated semiconductor detector with a newly designed stack-up parallel-hole collimator was developed and evaluated. The eValuator-2500 CZT pixelated semiconductor detector (eV product, Saxonburg, PA) was selected for the gamma camera system. This detector consisted of a row of four CZT crystals of 12.8 mm in length with 3 mm in thickness. The proposed parallel-hole collimator consists of two layers. The upper layer results in a fourfold increase in hole size compared to a matched square hole parallel-hole collimator with an equal hole and pixel size, while the lower layer also consisted of fourfold holes size and pretty acts as a matched square hole parallel-hole collimator. The overlap ratios of these collimators were 1:1, 1:2, 2:1, 1:5, and 5:1. These collimators were mounted on the eValuator-2500 CZT pixelated semiconductor detector. The basic performance of the imaging system was measured for a 57Co gamma source (122 keV). The measured averages of sensitivity and spatial resolution varied depending on the overlap ratios of the proposed parallel-hole collimator and source-to-collimator distances. One advantage of our system is the use of stacked collimators that can select the best combination of system sensitivity and spatial resolution. With low counts, we can select a high sensitivity collimator with a 1

  4. Performance evaluation of a small CZT pixelated semiconductor gamma camera system with a newly designed stack-up parallel-hole collimator

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Youngjin [Department of Radiological Science, College of Health Science, Eulji University, 553 Sanseong-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do 461-713 (Korea, Republic of); Kim, Hee-Joung, E-mail: hjk1@yonsei.ac.kr [Department of Radiological Science, College of Health Science, Yonsei University, 1 Yonseidae-gil, Wonju, Gangwon-do 220-710 (Korea, Republic of)

    2015-09-11

    Gamma ray imaging techniques that use a cadmium zinc telluride (CZT) or cadmium telluride (CdTe) pixelated semiconductor detectors have rapidly gained popularity as a key tool for nuclear medicine research. By using a pinhole collimator with a pixelated semiconductor gamma camera system, better spatial resolution can be achieved. However, this improvement in spatial resolution is accomplished with a decrease in the sensitivity due to the small collimator hole diameter. Furthermore, few studies have been conducted for novel parallel-hole collimator geometric designs with pixelated semiconductor gamma camera systems. A gamma camera system which combines a CZT pixelated semiconductor detector with a newly designed stack-up parallel-hole collimator was developed and evaluated. The eValuator-2500 CZT pixelated semiconductor detector (eV product, Saxonburg, PA) was selected for the gamma camera system. This detector consisted of a row of four CZT crystals of 12.8 mm in length with 3 mm in thickness. The proposed parallel-hole collimator consists of two layers. The upper layer results in a fourfold increase in hole size compared to a matched square hole parallel-hole collimator with an equal hole and pixel size, while the lower layer also consisted of fourfold holes size and pretty acts as a matched square hole parallel-hole collimator. The overlap ratios of these collimators were 1:1, 1:2, 2:1, 1:5, and 5:1. These collimators were mounted on the eValuator-2500 CZT pixelated semiconductor detector. The basic performance of the imaging system was measured for a {sup 57}Co gamma source (122 keV). The measured averages of sensitivity and spatial resolution varied depending on the overlap ratios of the proposed parallel-hole collimator and source-to-collimator distances. One advantage of our system is the use of stacked collimators that can select the best combination of system sensitivity and spatial resolution. With low counts, we can select a high sensitivity collimator

  5. Monitoring of the internal contamination of occupationally exposure personnel in services of nuclear medicine through the use of gamma cameras

    International Nuclear Information System (INIS)

    The radionuclides incorporation can happen as a result of diverse activities; these include the work associated with the different stadiums of the nuclear fuel cycle, the use of radioactive sources in medicine, the scientific research, the agriculture and the industry. In Uruguay the main activities linked to the manipulation of open sources correspond those of Nuclear Medicine and from 2004, in the mark of the Project Arcal RLA 049 and being based on the Safety Guides of the IAEA it is implementing a program of internal monitoring in combined form the Nuclear Medicine Center of the Hospital of and the Radiochemistry class of the Faculty of Chemistry. In accordance with the publication of the ICRP 75 the emphasis of any monitoring program should be in the formal study of the doses in the workers to who are considered commendable of to receive in routine form an outstanding fraction of the dose limits or who work in areas where the exposures can be significant in the accident event. From April 2004, to the date has started a pilot plan by means of in that were established appropriate conditions of procedures and of safety in a reduced group of workers of the Nuclear Medicine area. In that period the first work limits, equipment adjustment, calibrations and registration systems were determined. The monitoring system implemented until the moment is carried out with a thyroid caption equipment. However these measurements are carried out in the university hospital embracing 40% of the involved workers of our country, with the purpose of reaching the covering of the biggest quantity of occupationally exposed personnel of private clinics. Also it was developed a new work proposal that allows to have an alternative measure method, in the event of not having the equipment habitually used. Among the conclusions of this work are that for the before exposed are considered the measure conditions but appropriate the following ones: Gamma Camera without collimator; Measurement

  6. Multiple window spatial registration error of a gamma camera: 133Ba point source as a replacement of the NEMA procedure

    International Nuclear Information System (INIS)

    The accuracy of multiple window spatial resolution characterises the performance of a gamma camera for dual isotope imaging. In the present study we investigate an alternative method to the standard NEMA procedure for measuring this performance parameter. A long-lived 133Ba point source with gamma energies close to 67Ga and a single bore lead collimator were used to measure the multiple window spatial registration error. Calculation of the positions of the point source in the images used the NEMA algorithm. The results were validated against the values obtained by the standard NEMA procedure which uses a liquid 67Ga source with collimation. Of the source-collimator configurations under investigation an optimum collimator geometry, consisting of a 5 mm thick lead disk with a diameter of 46 mm and a 5 mm central bore, was selected. The multiple window spatial registration errors obtained by the 133Ba method showed excellent reproducibility (standard deviation < 0.07 mm). The values were compared with the results from the NEMA procedure obtained at the same locations and showed small differences with a correlation coefficient of 0.51 (p < 0.05). In addition, the 133Ba point source method proved to be much easier to use. A Bland-Altman analysis showed that the 133Ba and the 67Ga Method can be used interchangeably. The 133Ba point source method measures the multiple window spatial registration error with essentially the same accuracy as the NEMA-recommended procedure, but is easier and safer to use and has the potential to replace the current standard procedure

  7. The ISGRI CdTe gamma-ray camera: first steps

    CERN Document Server

    Limousin, O; Cretolle, J; Dzitko, H; Laurent, P; Lebrun, F; Leray, J P; Arques, M; Baffert, N; Mathy, F; Noca, A; Trystram, P; Villard, P; Baron, P; Delagnes, E; Rouger, M

    2000-01-01

    The gamma-ray telescope IBIS, on board the INTEGRAL satellite, features a coded-mask aperture, active and passive shields and two detector arrays. The first one (ISGRI) is an assembly of 16384 CdTe detectors (4x4 mm large, 2 mm thick) operating at room temperature. ISGRI covers the lower part (15 keV-1 MeV) of the IBIS energy range (15 keV-10 MeV). Detectors are arranged on polycells, each including 16 crystals, connected to their front-end electronics (ASICs). Each of the eight independent ISGRI modules are made of 128 polycells. The ASICs contain a low noise charge-sensitive preamplifier and feature pulse rise-time measurement in addition to the standard pulse height measurement. This permits to compute a charge loss correction based on the charge drift time. After application of this correction, a spectral resolution around 7.5% at 122 keV is obtained with the ASICs. Today, 16 polycells have been mounted on the first representative ISGRI module. This module has been interfaced with the entire ISGRI data-pr...

  8. The influence of electron multiplication and internal X-ray fluorescence on the performance of a scintillator-based gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Hall, David J., E-mail: d.j.hall@open.ac.uk [e2v centre for electronic imaging, The Open University, Walton Hall, Milton Keynes MK7 6AA (United Kingdom); Holland, Andrew; Soman, Matthew [e2v centre for electronic imaging, The Open University, Walton Hall, Milton Keynes MK7 6AA (United Kingdom)

    2012-06-21

    When considering the 'standard' gamma-camera, one might picture an array of photo-multiplier tubes or a similar array of small-area detectors. This array of imaging detectors would be attached to a corresponding array of scintillator modules (or a solid layer of scintillator) in order to give a high detection efficiency in the energy region of interest, usually 8-140 keV. Over recent years, developments of gamma-cameras capable of achieving much higher spatial resolutions have led to a new range of systems based on Charge-Coupled Devices with some form of signal multiplication between the scintillator and the CCD in order for one to distinguish the light output from the scintillator above the CCD noise. The use of an Electron-Multiplying Charge-Coupled Device (EM-CCD) incorporates the gain process within the CCD through a form of 'impact ionisation', however, the gain process introduces an 'excess noise factor' due to the probabilistic nature of impact ionisation and this additional noise consequently has an impact on the spatial and spectral resolution of the detector. Internal fluorescence in the scintillator, producing K-shell X-ray fluorescence photons that can be detected alongside the incident gamma-rays, also has a major impact on the imaging capabilities of gamma-cameras. This impact varies dramatically from the low spatial resolution to high spatial resolution camera system. Through a process of simulation and experimental testing focussed on the high spatial resolution (EM-CCD based) variant, the factors affecting the performance of gamma-camera systems are discussed and the results lead to important conclusions to be considered for the development of future systems. This paper presents a study into the influence of the EM-CCD gain process and the internal X-ray fluorescence in the scintillator on the performance of scintillator-based gamma cameras (CCD-based or otherwise), making use of Monte Carlo simulations to demonstrate

  9. Intraoperative Scintigraphy Using a Large Field-of-View Portable Gamma Camera for Primary Hyperparathyroidism: Initial Experience

    Directory of Open Access Journals (Sweden)

    Nathan C. Hall

    2015-01-01

    Full Text Available Background. We investigated a novel technique, intraoperative 99 mTc-Sestamibi (MIBI imaging (neck and excised specimen (ES, using a large field-of-view portable gamma camera (LFOVGC, for expediting confirmation of MIBI-avid parathyroid adenoma removal. Methods. Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to incision (neck and immediately following resection (neck and/or ES. Preoperative and intraoperative serum parathyroid hormone monitoring (IOPTH and pathology (path were also performed. Results. MIBI neck activity was absent and specimen activity was present in 13/20 with imaging after initial ES removal. In the remaining 7/20 cases, residual neck activity and/or absent ES activity prompted excision of additional tissue, ultimately leading to complete hyperfunctioning tissue excision. Postexcision LFOVGC ES imaging confirmed parathyroid adenoma resection 100% when postresection imaging qualitatively had activity (ES and/or no activity (neck. The mean ± SEM time saving using intraoperative LFOVGC data to confirm resection versus first IOPTH or path result would have been 22.0 ± 2 minutes (specimen imaging and 26.0 ± 3 minutes (neck imaging. Conclusion. Utilization of a novel real-time intraoperative LFOVGC imaging approach can provide confirmation of MIBI-avid parathyroid adenoma removal appreciably faster than IOPTH and/or path and may provide a valuable adjunct to parathyroid surgery.

  10. Non-invasive estimation of the human pulmonary blood volume with gamma camera and RI-angiocardiography

    International Nuclear Information System (INIS)

    A new, non-invasive method for the estimation of the human pulmonary blood volume (PBV), existing between the pulmonary artery bifurcation (PAB) and the left atrium (LA), has been developed in this laboratory, in the form of PBV = PPT sub(RCG) x 0.77 x CO, equation (6), given in Appendix. This was an extension of the classical Stewart-Hamilton method of indicator dilution, applied to radioisotope angiocardiography. Using a gamma-camera, the radio-isotope (99 m Tc-albumin) dilution curves were recorded externally at the region of PAB, LA and LV (left ventricle), among other things, in human subjects in supine position. The mean transit time (MTT) was determined for each region, and the difference in MTT, e.g., ΔMTT sub(PAB-LA), was measured. We calculated PBV between PAB and LA as PBV = ΔMTT sub(PAB-LA) x CO, equation (1) given in Appendix. Empirical time relations between ΔMTT sub(PAB-LA) and PPT sub(RCG) were examined in mechanical models and human subjects, through several steps represented by equations (2) to (5), given in Appendix, and our tentatively final formula was equation (6). The values of PBV estimated in this way were in good agreement with those of PBV measured invasively in the past, using two injection sites (PA and LA) and one sampling site (artery). (author)

  11. [Initial experience in intraoperative radiolocalization of the parathyroid adenoma with freehand SPECT and comparative assessment with portable gamma-camera].

    Science.gov (United States)

    Casáns-Tormo, I; Prado-Wohlwend, S; Díaz-Expósito, R; Cassinello-Fernández, N; Ortega-Serrano, J

    2015-01-01

    Initial experience is presented by using freehand SPECT in the intraoperative radiolocalization of a parathyroid adenoma in 2 patients, one which was mediastinal. There is only one previous publication including 3 patients with parathyroid adenomas in usual parathyroid localizations. We also report for the first time a comparative assessment of results with portable gammacamera during the same surgery. In the operating room, we obtained images with portable gamma-camera and 3 D reconstruction with freehand SPECT from 15 min after iv injection of 5 mCi of (99m)Tc-MIBI. Both devices enabled the 2 adenomas to be detected intraoperatively, as well as checking activity of the excised gland and absence of significant uptake in surgical bed, with confirmation by intraoperative pre-postsurgical PTH levels, pathology and clinical follow-up for 10 months. Both devices accurately located the parathyroid adenomas intraoperatively, as well as confirmation of their extirpation, but freehand SPECT provided additional information of adenoma depth (mm) from the skin border, very useful for minimally invasive radio-guided surgery. PMID:25577326

  12. Compton camera and prompt gamma ray timing: two methods for in vivo range assessment in proton therapy

    Directory of Open Access Journals (Sweden)

    Fernando eHueso-González

    2016-04-01

    Full Text Available Proton beams are promising means for treating tumours. Such charged particles stop at a defined depth, where the ionization density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimises the damage to normal tissue compared to photon therapy. Nevertheless, inherent range uncertainties cast doubts on the irradiation of tumours close to organs at risk and lead to the application of conservative safety margins. This constrains significantly the potential benefits of protons over photons. In this context, several research groups are developing experimental tools for range verification based on the detection of prompt gammas, a nuclear by-product of the proton irradiation. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf, detector components have been characterised in realistic radiation environments as a step towards a clinical Compton camera. Corresponding experimental methods and results obtained during the ENTERVISION training network are reviewed. On the other hand, a novel method based on timing spectroscopy has been proposed as an alternative to collimated imaging systems. The first tests of the timing method at a clinical proton accelerator are summarised, its applicability in a clinical environment for challenging the current safety margins is assessed, and the factors limiting its precision are discussed.

  13. Assessment of spleen size using gamma camera scintigraphy in newly diagnosed patients with essential thrombocythaemia and polycythaemia vera

    Energy Technology Data Exchange (ETDEWEB)

    Carneskog, J.; Wadenvik, H.; Kutti, J. [Univ. of Goeteborg, Sahlgrenska Univ. Hospital, Dept. of Medicine, Haematology Section, Goeteborg (Sweden); Fjaeelling, M. [Univ. of Goeteborg, Sahlgrenska Univ. Hospital, Dept. of Clinical Physiology, Section of Nuclear Med., Goeteborg (Sweden)

    1996-03-01

    By using gamma camera imaging the spleen size was assessed in 18 consecutive patients with essential thrombocythaemia (ET) and in 18 consecutive patients with polycythaemia vera (PV). All ET and PV patients were newly diagnosed and had not received any myelosuppressive therapy prior to study. The spleen areas in both posterior and left lateral projections were determined. Eighteen consecutive patients with idiopathic thrombocytopenic purpura (ITP) served as a control group since by definition they do not present with splenic enlargement; in these latter subjects the mean posterior and left lateral splenic areas were almost identical (48 {+-} 15 and 47 {+-} 17 cm{sup 2}, respectively). In comparison with this control group patients with ET an dPV had significantly larger spleens. In both ET and in PV patients the left lateral spleen scan area exceeded the posterior one. Patients with PV had larger splenic areas in both projections than did patients with ET, but the differences were not statistically significant. Compared to the ITP patients it was found that at least 50% of the ET patients and at least 61% of the PV patients at diagnosis presented with splenomegaly. (au) 35 refs.

  14. Is. gamma. -camera imaging of platelet deposition useful to assess the effectiveness of prostacyclin (PGI/sub 2/) treatment

    Energy Technology Data Exchange (ETDEWEB)

    Fitscha, P.; Kaliman, J.; Sinziger, H. (Vienna Univ. (Austria))

    Platelet labelling with /sup 111/In-oxinesulfate allows visualization of platelet deposition in the vascular bed. Scintigraphic studies were performed in 6 patients with 'active' (platelet uptake ratio (PUR) > 1.20) and 8 patients with 'inactive' (PUR < 1.20) atherosclerotic lesions of the femoral artery. Platelet deposition was also studied in 11 patients with implanted prosthetic vascular grafts and in 21 patients with an abnormal aneurysm of the aorta. Infusing 5 ng/kg/min PGI/sub 2/ during 6 hours for 5 days into patients with 'active'-atherosclerosis and aneurysms of the aorta resulted in a significant decrease of platelet deposition even after having stopped the infusion. There was no influence of PGI/sub 2/ on PUR in patients with 'inactive' lesions. The group of patients with implanted prosthetic grafts demonstrated also a significant decrease of PUR values during the PGI/sub 2/ infusion, but reached baseline values soon after stopping the infusion. When platelet deposition is increased ..gamma..-camera imaging provides valuable data on the influence of any kind of therapy on the in-vivo platelet function.

  15. Functional studies of the oesophagus with sulfur-colloid of sup(99m)Tc and gamma-camera

    International Nuclear Information System (INIS)

    A scintiscanning technique which allows sequential detection and quantification of gastro-oesophageal reflux (GER), and study of the oesophageal emptying of a liquid and semi-solid food is presented. At first patients swallowed 5 ml of water containing 1 mCi sup(99m)Tc sulfur-colloid and oesophageal activity is recorded from an anterior view by a gamma-camera. Then, patients ingest 300 ml of water that clear the oesophagus and fill up the stomach. GER index is calculated according to the formula GER = (Ae - Ab)/Ag) x 100, where Ae is the activity in the oesophagus; Ab, is the background activity; and Ag is the gastric activity. GER index presented corresponds to a median of three determinations in upright, supine and supine position with abdominal pressure of 4 kilos. The oesophageal transit time of a semi-solid food in upright and supine position is registered 5 minutes after GER studies through two areas of interest which are positioned: one in the superior third and the other in the inferior third of the oesophagus. Normal GER reflux index was, 0.84 +- 0.37 in the upright position; 0.87 +- 0.43 in the supine position; and 0.90 +- 0.56 in the supine position plus abdominal pressure

  16. Simulation of a multi-detector gamma camera for validation protocols of quantification the activity from SPECT images

    International Nuclear Information System (INIS)

    The main sources that decreasing accuracy in the estimation of internal absorbed dose has been identified in the methods for the quantification of cumulated activity from scintigraphic imaging, likes the corrections required by the physical and instrumental phenomena related to the formation of those images. The results of the simulation of a dual detector gamma camera E.cam SIEMENS using the Monte Carlo code SIMIND to obtain tomographic SPECT projections are presented here. SIMIND will allow dealing with the contribution of physical interactions and instrumental effects during simulations. Energy resolution, spatial resolution and sensitivity planar were determined with real and simulated systems. The relative differences did not exceed 10%. Energy spectra simulated under different conditions (source in air and water) with the inclusion of interactions in the collimator and phantom were compared. The tomographic sensitivity of a volumetric phantom containing radioactive solutions of 99mTc and 131I were determined from real and simulated SPECT images. Two processing protocols were considered: with scatter correction (99mTc dual energy window method and 131I were calculated after corrections. The results, expressed in terms of the differences relative to the well-know activity value in the phantom inserts improves when attenuation and scattering corrections are applied, obtaining good agreement between the results for real and simulated systems. (Author)

  17. Diagnosis of pancreatic cancer using 201Tl-chloride and a three-head rotating gamma camera SPECT system

    International Nuclear Information System (INIS)

    201Tl SPECT was performed on 17 patients with pancreatic cancer or chronic pancreatitis using a three-head rotating gamma camera SPECT system. In 7 of 10 patients with pancreatic cancer, the lesions were clearly delineated by 201Tl SPECT. Whereas the lesion of 30 mm in diameter was visualized, a large tumor of 80 mm in diameter could not be visualized. Namely, it was thought that 201Tl uptake by pancreatic cancer might be well correlated with tumor blood flow and/or its histological subtype rather than with tumor size. In 5 of 7 patients with chronic pancreatitis, no uptake by the pancreas was shown. The sensitivity, specificity, and accuracy in diagnosing pancreatic cancer by 201Tl SPECT were 70%, 71%, and 71%, respectively. The present results obtained by 201Tl SPECT were thought satisfactory enough to evaluate pancreatic cancer under the present conditions where there was no useful imaging agent for visualizing pancreatic cancer by SPECT. 201Tl SPECT is expected to be a new diagnostic tool for investigation of pancreatic tumorous lesion. (author)

  18. Compton Camera and Prompt Gamma Ray Timing: Two Methods for In Vivo Range Assessment in Proton Therapy

    Science.gov (United States)

    Hueso-González, Fernando; Fiedler, Fine; Golnik, Christian; Kormoll, Thomas; Pausch, Guntram; Petzoldt, Johannes; Römer, Katja E.; Enghardt, Wolfgang

    2016-01-01

    Proton beams are promising means for treating tumors. Such charged particles stop at a defined depth, where the ionization density is maximum. As the dose deposit beyond this distal edge is very low, proton therapy minimizes the damage to normal tissue compared to photon therapy. Nevertheless, inherent range uncertainties cast doubts on the irradiation of tumors close to organs at risk and lead to the application of conservative safety margins. This constrains significantly the potential benefits of protons over photons. In this context, several research groups are developing experimental tools for range verification based on the detection of prompt gammas, a nuclear by-product of the proton irradiation. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf, detector components have been characterized in realistic radiation environments as a step toward a clinical Compton camera. On the one hand, corresponding experimental methods and results obtained during the ENTERVISION training network are reviewed. On the other hand, a novel method based on timing spectroscopy has been proposed as an alternative to collimated imaging systems. The first tests of the timing method at a clinical proton accelerator are summarized, its applicability in a clinical environment for challenging the current safety margins is assessed, and the factors limiting its precision are discussed. PMID:27148473

  19. Reliability of a 99sp(m)Tc-DTPA gamma camera technique for determination of single kidney glomerular filtration rate

    International Nuclear Information System (INIS)

    In a recent paper we described a method for calculation of single kidney glomerular filtration rate (SKGFR) from the 99sp(m)Tc-DTPA renogram obtained by gamma camera. In this paper the reliability of the method was compared to other methods for estimation of GFR in 20 unilaterally nephrectomized patients. The values for SKGFR obtained from the renograms and from the estimated endogenous creatinine clearances according to serum creatinine concentration and a nomogram were both accurate. The reliability of the renography method was significantly better judged by less variance in the estimates. SKGFR calculated from the plasma clearance of 51Cr-EDTA overestimated the renal clearance of inulin on an average by 11.3%. No difference was found in the variance of the values obtained from the renograms and from the plasma clearances of 51Cr-EDTA compared to the renal clearance of inulin. Apart from the inaccuracy in the GFR values calculated from the plasma clearance of 51Cr-EDTA, the reliability of these two methods was equal. (author)

  20. Extensive testing of Schottky CdTe detectors for the ECLAIRs X-Gamma-ray Camera on board the SVOM mission

    OpenAIRE

    Nadege, Remoue; Didier, Barret; Olivier, Godet; Pierre, Mandrou

    2010-01-01

    We report on an on-going test campaign of more than 5000 Schottky CdTe detectors (4x4x1 mm^3), over a sample of twelve thousands, provided by Acrorad Co., Ltd (Japan). 6400 of these detectors will be used to build the detection plane of the ECLAIRs camera on the Chinese-French gamma-ray burst mission SVOM. These tests are mandatory to fulfill the prime requirement of ECLAIRs to detect gamma-ray burst photons down to 4 keV. The detectors will be operated at -20C under a reverse bias of 600 V. ...

  1. Scintillation camera and positron camera

    International Nuclear Information System (INIS)

    A short description is given of earlier forms of the gamma-ray camera. The principle of operation of the scintillation camera is reviewed. Here the locations of scintillations occurring in a flat thallium-activated sodium iodide crystal are determined from the amount of light picked up by a number of phototubes simultaneously viewing the crystal. The signals from the phototubes are fed to a deflection computor circuit which reproduces the scintillations on a cathode-ray tube screen. There they are photographed by a conventional scope camera. Examples are shown of the resolution now obtained as shown by test phantoms. A discussion is presented of the camera's use in visualizing the thyroid in clinical practice. (author)

  2. Waste reduction efforts through the evaluation and procurement of a digital camera system for the Alpha-Gamma Hot Cell Facility at Argonne National Laboratory-East

    International Nuclear Information System (INIS)

    The Alpha-Gamma Hot Cell Facility (AGHCF) at Argonne National Laboratory-East is a research facility where sample examinations involve traditional photography. The AGHCF documents samples with photographs (both Polaroid self-developing and negative film). Wastes generated include developing chemicals. The AGHCF evaluated, procured, and installed a digital camera system for the Leitz metallograph to significantly reduce labor, supplies, and wastes associated with traditional photography with a return on investment of less than two years

  3. Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters

    OpenAIRE

    Cambraia Lopes, P; Clementel, E; Crespo, P; Henrotin, S; Huizenga, J.; G. Janssens; Parodi, K.; Prieels, D.; Roellinghoff, F; Smeets, J.; Stichelbaut, F.; Schaart, D. R.

    2015-01-01

    Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of neutron-induced background counts. In this work, we present an initial performance test of two knife-edge slit camera prototypes based on arrays of digita...

  4. Evaluation of crossing calibration of 123I-MIBG H/M ration, with the IDW scatter correction method, on different gamma camera systems

    International Nuclear Information System (INIS)

    123I-metaiodobenzylguanidine (123I-MIBG) Heart-to-Mediastinum activity ratio (H/M) is commonly used as an indicator of relative myocardial 123I-MIBG uptake. H/M ratios reflect myocardial sympathetic nerve function, therefore it is a useful parameter to assess regional myocardial sympathetic denervation in various cardiac diseases. However, H/M ratio values differ by site, gamma camera system, position and size of region of interest (ROI), and collimator. In addition to these factors, 529 keV scatter component may also affect 123I-MIBG H/M ratio. In this study, we examined whether the H/M ratio shows correlation between two different gamma camera systems and that sought for H/M ratio calculation formula. Moreover, we assessed the feasibility of 123I Dual Window (IDW) method, which is a scatter correction method, and compared H/M ratios with and without IDW method. H/M ratio displayed a good correlation between two gamma camera systems. Additionally, we were able to create a new H/M calculation formula. These results indicated that the IDW method is a useful scatter correction method for calculating 123I-MIBG H/M ratios. (author)

  5. Cerebral emission computer tomography with a rotating gamma camera: clinic results with J-123 Isopropylamphetamin and J-123-Fenetyllin

    International Nuclear Information System (INIS)

    Many amines can pass the blood brain barrier and accumulate in relatively large amounts in the brain tissue. For about 2 years 123-J amphetamines have, therefore, been used for brain imaging by several teams. Our experience sofar is based on 28 patients. Of these, 14 were epileptics, 10 had cerebrovascular diseases, 2 suffered from migraine and another 2 had brain tumors. In 3 patients with vascular lesions studies were repeated twice or three times. Amphetamine uptake in the brain was measured with a rotating gamma camera system (Gammatome T9000/CGR). At an examination time of 20 minutes 64 frames were acquired during one full rotation. The pulse rate was about 3000 second after injecting 6.5 mCi of 123-J amphetamine. Of the epileptics, 8 showed defects both on CT and SPECT, in 3 cases both studies were normal. While 1 patient with CT positivity had a normal SPECT, 2 cases were found to have lesions on SPECT inspite of a normal CT. The size of the lesion seen on amphetamine SPECT was lager than on CT in 3 of 9 patients. In the 10 patients with cerebrovascular lesions the 2 procedures showed concordant normal patterns in 1 and concordant abnormal patterns in 7 instances. 2 patients with normal CT were found to have a lesion on amphetamine scanning which corresponded to the neurologic findings. Regarding the size of the lesions, SPECT showed a more extensive involvement than CT in 2 cases. This again was in good agreement with the neurologic findings. Inspite of repeat studies cerebellar diaschisis was only seen in a single case with healed cerebral infarction and hemiplegia of some years' standing. Two patients suffered from migraine and compromised blood flow was identified as suggested by the neurologic findings inspite of a normal CT. (Author)

  6. Evaluation of safe use of 188Re-HEDP comparing urine data and whole body counting in gamma camera

    International Nuclear Information System (INIS)

    Cancer is the second more frequent cause of death, after cardiovascular disease, in developing countries. Most of adult patients with neoplasms will develop skeletal metastases that can lead to progressive pain. 188Re emits both beta particles suitable for therapy and a gamma ray (155 keV), adequate for diagnostic imaging in order to verify localization in the pain areas associated to metastatic process. The aim of this work was to correlate 188Re-HEDP dose estimations using biological samples and direct measures. All the patients had breast or prostate cancer, with bone metastases. Each patient received a tracer dose of 185 MBq of radiopharmaceutical. Urine samples were collected at 0-1, 1-2, 2-4 and, 4-6 hours post administration, and measured in dose calibrator. Whole body counts were acquired using a camera without collimator, window centered at 155 KeV, matrix 256 x 256, during 60 seconds. Data were obtained at 1 and 6 hours post administration with the patient in sitting position at 2 meter from the detector. Percentage of injected dose was calculated both for urine samples and image for each patient. The number of disintegrations was determined for organs in which higher concentration of activity was observed: those involved in the excretion, red marrow and the reminder of the body. Total doses were estimated using OLINDA/EXM software. Conclusions: Data showed that the organs chosen as more compromised during the tracer dose procedure received very low effective doses. A good correlation between calculations performed both for image and urine samples was obtained. Safety of the radiopharmaceutical was also verified using this method. (author)

  7. Development of new gamma camera localization method for sentinel nodes by image fusion and navigation in lymphoscintigraphy

    International Nuclear Information System (INIS)

    Full text: The objective of this study was the development of the localization technique for skin marking the lesions with low accumulating Tc-99m labeled radiopharmaceuticals. Fusion of high count static planar scan (base image) with real time acquired scan (fluent image) and with added moving point source (Tc-99m or Co-57) in the same patient position was performed for best overlapping the target lesions and point source spot. Special acquisition software in Windows (Oncology MedicView) was developed. Both images were pre-processed by online visual inspection and then fluently fused in the way that only point source spot is overlapped to the base image. Image normalization was done by linear, log or combined log/linear conversions followed by on-line contrasting of fused image by high sensitive color scaling and spatial contrast filtering. The localization was performed in several patient positions with fixed bed and patient. Navigation tools using audio and visual signals were continuously created from the 'lesion-point source spot' distance information. Localization accuracy for SLN(s) using this technique was considerably high. SLN detection improved from 76 % (95 patients, 72 detected SLNs, 23 undetectable SLNs) to 95 % (45 pts, 42 detected SLNs, 3 undetectable SLNs). Localization procedure was shortened for at least 3 times. The new technique substantially lowered the localization time and increased the lesion detection by on-line interactive optimization of fused images. It can be used for all radioisotope localizations in oncology diagnostics using simple analog or semi digital gamma cameras connected to low-cost IAEA acquisition module and specially developed acquisition/processing software. (author)

  8. Design of ultra-high-energy, high-resolution and high-sensitivity collimators for gamma cameras

    International Nuclear Information System (INIS)

    Recently, small object imaging using positron emitters, such as fluorine-18-2-deoxyglucose, has focused on basic nuclear medicine techniques. We have designed and developed ultra-high-energy high-resolution collimators for small object imaging. Firstly, we produced an ultra-high-energy pinhole collimator. The thickness of the lead shielding was 30 mm. The pinhole diameter of knife-edge aperture was 0.6 mm. The acceptance angle was 13 deg. This cylinder was equipped with a non-collimator gamma camera at a distance of 30.5 cm. The radius of rotation was 6 cm and the magnification was 5.1 times. In simulation calculations, as the pinhole-object distance decreased, geometric sensitivity increased geometrically. However, as the pinhole-object-distance decreased, field-of-view (FOV) decreased linearly. Spatial resolution was measured using a line source of 18F and was 2.4 mm at full-width-at-half-maximum and 9.5 mm at full-width-at-tenth-maximum. The sensitivity of the system was 6.8 counts sec-1 MBq-1 using a point source of 18F. In addition, sensitivity at the rim of FOV was lower than that at the center. Next, we designed an ultra-high-energy converging collimator. It was found that the converging collimator had uniform sensitivity over the FOV. Also, the FOV at smaller collimator-object distances was not as restricted as the ultra-high-energy pinhole collimator. Thus, we demonstrated that high-resolution images for ultra-high-energy imaging could be acquired using the pinhole collimator. Moreover, we believe that the ultra-high-energy converging collimator could be available for a clinical study. (author)

  9. Imaging performance comparison between a LaBr3: Ce scintillator based and a CdTe semiconductor based photon counting compact gamma camera.

    Science.gov (United States)

    Russo, P; Mettivier, G; Pani, R; Pellegrini, R; Cinti, M N; Bennati, P

    2009-04-01

    The authors report on the performance of two small field of view, compact gamma cameras working in single photon counting in planar imaging tests at 122 and 140 keV. The first camera is based on a LaBr3: Ce scintillator continuous crystal (49 x 49 x 5 mm3) assembled with a flat panel multianode photomultiplier tube with parallel readout. The second one belongs to the class of semiconductor hybrid pixel detectors, specifically, a CdTe pixel detector (14 x 14 x 1 mm3) with 256 x 256 square pixels and a pitch of 55 microm, read out by a CMOS single photon counting integrated circuit of the Medipix2 series. The scintillation camera was operated with selectable energy window while the CdTe camera was operated with a single low-energy detection threshold of about 20 keV, i.e., without energy discrimination. The detectors were coupled to pinhole or parallel-hole high-resolution collimators. The evaluation of their overall performance in basic imaging tasks is presented through measurements of their detection efficiency, intrinsic spatial resolution, noise, image SNR, and contrast recovery. The scintillation and CdTe cameras showed, respectively, detection efficiencies at 122 keV of 83% and 45%, intrinsic spatial resolutions of 0.9 mm and 75 microm, and total background noises of 40.5 and 1.6 cps. Imaging tests with high-resolution parallel-hole and pinhole collimators are also reported. PMID:19472638

  10. Evaluation of the difference-correction effect of the gamma camera systems used by easy Z-score Imaging System (eZIS) analysis

    International Nuclear Information System (INIS)

    We examined the difference of the effect by data to revise a gamma camera difference. The difference-correction method of the camera is incorporated in eZIS analysis. We acquired single photon emission computed tomography (SPECT) data from the three-dimensional (3D) Hoffman brain phantom (Hoffman), the three-dimensional brain phantom (3D-Brain), Pool phantom (pool) and from normal subjects (Normal-SPECT) to investigate compensating for a difference in gamma camera systems. We compared SPECT counts of standard camera with the SPECT counts that revised the difference of the gamma camera system (camera). Furthermore, we compared the 'Z-score map (Z-score)'. To verify the effect of the compensation, we examined digitally simulated data designed to represent a patient with Alzheimer's dementia. We carried out both eZIS analysis and 'Specific Volume of interest Analysis (SVA)'. There was no great difference between the correction effect using Hoffman phantom data and that using 3D-Brain phantom data. Furthermore, a good compensation effect was obtained only over a limited area. The compensation based on the pool was found to be less satisfactory than any of the other compensations according to all results of the measurements examined in the study. The compensation based on the Normal-SPECT data resulted in a Z-score map (Z-score) for the result that approximated that from the standard camera. Therefore, we concluded that the effect of the compensation based on Normal-SPECT data was the best of the four methods tested. Based on eZIS analysis, the compensation using the pool data was inferior to the compensations using the other methods tested. Based on the results of the SAV analysis, the effect of the compensation using the Hoffman data was better than the effect of the compensation using the 3D-Brain data. By all end-point measures, the compensation based on the Normal-SPECT data was more accurate than the compensation based on any of the other three phantoms. (author)

  11. Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera

    International Nuclear Information System (INIS)

    The aim of this study was to assess the ability of real-time breath-hold-triggered myocardial perfusion imaging (MPI) using a novel cadmium-zinc-telluride (CZT) gamma camera to discriminate artefacts from true perfusion defects. A group of 40 patients underwent a 1-day 99mTc-tetrofosmin pharmacological stress/rest imaging protocol on a conventional dual detector SPECT gamma camera with and without attenuation correction (AC), immediately followed by scanning on an ultrafast CZT camera with and without real-time breath-hold triggering (instead of AC) by intermittent scanning confined to breath-hold at deep inspiration (using list mode acquisition). We studied the use of breath-hold triggering on the CZT camera and its ability to discriminate artefacts from true perfusion defects using AC SPECT MPI as the reference standard. Myocardial tracer uptake (percent of maximum) from CZT was compared to AC SPECT MPI by intraclass correlation and by calculating Bland-Altman limits of agreement. AC of SPECT MPI identified 19 apparent perfusion defects as artefacts. Of these, 13 were correctly identified and 4 were partially unmasked (decrease in extent and/or severity) by breath-hold triggering of the CZT scan. All perfusion defects verified by SPECT MPI with AC were appropriately documented by CZT with and without breath-hold triggering. This was supported by the quantitative analysis, as the correlation (r) of myocardial tracer uptake between CZT and AC SPECT improved significantly from 0.81 to 0.90 (p<0.001) when applying breath-hold triggering. Similarly, Bland-Altman limits of agreement were narrower for CZT scans with breath-hold triggering. This novel CZT camera allows real-time breath-hold triggering as a potential alternative to AC to assist in the discrimination of artefacts from true perfusion defects. (orig.)

  12. Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmium-zinc-telluride detector gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Buechel, Ronny R.; Pazhenkottil, Aju P.; Herzog, Bernhard A.; Husmann, Lars; Nkoulou, Rene N.; Burger, Irene A.; Valenta, Ines; Wyss, Christophe A.; Ghadri, Jelena R. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University of Zurich, Zurich Center for Integrative Human Physiology (ZIHP), Zurich (Switzerland)

    2010-10-15

    The aim of this study was to assess the ability of real-time breath-hold-triggered myocardial perfusion imaging (MPI) using a novel cadmium-zinc-telluride (CZT) gamma camera to discriminate artefacts from true perfusion defects. A group of 40 patients underwent a 1-day {sup 99m}Tc-tetrofosmin pharmacological stress/rest imaging protocol on a conventional dual detector SPECT gamma camera with and without attenuation correction (AC), immediately followed by scanning on an ultrafast CZT camera with and without real-time breath-hold triggering (instead of AC) by intermittent scanning confined to breath-hold at deep inspiration (using list mode acquisition). We studied the use of breath-hold triggering on the CZT camera and its ability to discriminate artefacts from true perfusion defects using AC SPECT MPI as the reference standard. Myocardial tracer uptake (percent of maximum) from CZT was compared to AC SPECT MPI by intraclass correlation and by calculating Bland-Altman limits of agreement. AC of SPECT MPI identified 19 apparent perfusion defects as artefacts. Of these, 13 were correctly identified and 4 were partially unmasked (decrease in extent and/or severity) by breath-hold triggering of the CZT scan. All perfusion defects verified by SPECT MPI with AC were appropriately documented by CZT with and without breath-hold triggering. This was supported by the quantitative analysis, as the correlation (r) of myocardial tracer uptake between CZT and AC SPECT improved significantly from 0.81 to 0.90 (p<0.001) when applying breath-hold triggering. Similarly, Bland-Altman limits of agreement were narrower for CZT scans with breath-hold triggering. This novel CZT camera allows real-time breath-hold triggering as a potential alternative to AC to assist in the discrimination of artefacts from true perfusion defects. (orig.)

  13. Simulation study on a stationary data acquisition SPECT system with multi-pinhole collimators attached to a triple-head gamma camera system

    International Nuclear Information System (INIS)

    The aim of the study was to develop a new SPECT system that makes it possible to acquire projection data stationary using a triple-head gamma camera system. We evaluated several data acquisition geometry with multi-pinhole collimators attached to a triple-head gamma camera system. The number of pinholes for each camera was three to twelve, and we located these holes on collimator plates adequately. These collimator holes were tilted by predefined angles to efficiently cover the field of view of the data acquisition system. Acquired data were reconstructed with the OS-EM method. In the simulations, we used a three-dimensional point source phantom, brain phantom, and myocardial phantom. Attenuation correction was conducted with the x-ray CT image of the corresponding slice. Reconstructed images of the point source phantom showed that the spatial resolution could be improved with the small number of pinholes. On the other hand, reconstructed images of the brain phantom showed that the large number of pinholes yielded images with less artifact. The results of the simulations with the myocardial phantom showed that more than eight pinholes could yield an accurate distribution of activity when the source was distributed only in the myocardium. The results of the simulations confirmed that more than eight pinholes for each detector were required to reconstruct an artifact free image in the triple-head SPECT system for imaging of brain and myocardium. (author)

  14. Evaluation of list-mode ordered subset expectation maximization image reconstruction for pixelated solid-state compton gamma camera with large number of channels

    International Nuclear Information System (INIS)

    The Voxel Imaging PET (VIP) Pathfinder project intends to show the advantages of using pixelated solid-state technology for nuclear medicine applications. It proposes designs for Positron Emission Tomography (PET), Positron Emission Mammography (PEM) and Compton gamma camera detectors with a large number of signal channels (of the order of 106). For Compton camera, especially with a large number of readout channels, image reconstruction presents a big challenge. In this work, results are presented for the List-Mode Ordered Subset Expectation Maximization (LM-OSEM) image reconstruction algorithm on simulated data with the VIP Compton camera design. For the simulation, all realistic contributions to the spatial resolution are taken into account, including the Doppler broadening effect. The results show that even with a straightforward implementation of LM-OSEM, good images can be obtained for the proposed Compton camera design. Results are shown for various phantoms, including extended sources and with a distance between the field of view and the first detector plane equal to 100 mm which corresponds to a realistic nuclear medicine environment

  15. Correlation between glomerular filtration rate with gamma camera and estimated serum creatinine clearance from Cockcroft and Gault's formula

    International Nuclear Information System (INIS)

    The purpose of the present study is to find out the correlation between the glomerular filtration rate (GFR by Gates gamma camera method) and serum creatinine clearance (SCrCl by Cockcroft and Gault's method) within ± 3 weeks’ time difference. Study design retrospectively in 59 patients with serum creatinine value calculated for SCrCl with Cockcroft and Gault's formula as an index parameter for kidney function underwent the 99m-Technitium labeled Di-ethyl Triamine Penta Acetic Acid (99mTc-DTPA) renogram with ECIL planar gamma camera. All data of 59 patients has been divided into Group- I, II, and III based on the time difference of serum creatinine test from 99mTc-DTPA renal GFR tests performed on the same subjects. Serum Creatinine test was carried out within ± 3 days, between ± 4 days and ± 7 days, and between ± 8 days and ± 21 days from the DTPA GFR Test performed in the Group-I, II, and III respectively. Correlation coefficient of Group-I (n = 15) patients showed 0.8198 and P value < 0.001 for GFR and S. Creatinine within ± 3 days. Group-II (n = 17) and Group-III (n = 27) patients having correlation coefficient 0.6194 and 0.589 and P value <0.01 respectively, within ± 21 days. The two methods gave almost identical estimate of GFR even at 3 weeks interval. Study concludes that SCrCl using Cockcroft and Gault's formula could serve as an instant, easy, and reliable method for assessing kidney function. SCrCl with Cockcroft and Gault's formula is more useful for rapid estimation of global GFR for those patients who are not accessible to DTPA renogram with gamma camera. Correlation can be established further with the prospective study in various renal pathophysiological conditions

  16. Lymphoscintigraphy of melanoma. Lymphatic channel activity guides localization of sentinel lymph nodes, and gamma camera imaging/counting confirms presence of radiotracer in excised nodes

    International Nuclear Information System (INIS)

    Lymphoscintigraphy has become a standard preoperative procedure to map the cutaneous lymphatic channel for progression of nodal metastasis of melanoma of the skin. Lymphoscintigraphy was employed to visualize lymphatic channels as a guide to identify sentinel lymph nodes (SLNs). Excised tissue was imaged with a gamma camera to verify the findings of presurgical lymphoscintigraphy. Percent counts of SLN(s) among the total counts of the excised melanoma tumor or scar tissue and SLN(s) were calculated. Eleven patients with cutaneous melanoma received four to ten intradermal injections of Tc-99m sulfur colloid at elual distances around the melanoma site. Images were made immediately after injection: 1 minute per image for 15 min; and then 5 minutes or 1,000,000 counts per image for 30 min. After surgery, the excised melanoma tumor or scar and SLN(s) were imaged/counted with a gamma camera. Percent counts of SLNs among the total counts of the excised melanoma tumor or scar tissue and SLNs were calculated. To validate the specimen count accuracy, an experimental phantom study was done. Linear lymphatic channels were identified between the injected sites and the SLNs in each patient. Gamma camera images demonstrated radioactivity in the SLNs of all patients, verifying the lymphoscintigraphy findings. Uptake in the SLNs of ten of the eleven patients ranged from 0.4 to 7.2% (mean 2.2%) of the total counts in excised tissue. We noted that a node with lower uptake should not be ignored because a lower percent of SLN activity does not necessarily rule out existing metastasis. In two of eleven patients, histopathologic showed metastases. One patient's melanoma on the middle back had lymphatic channel activity directed to both axillae. The results of the phantom study validated accuracy of our specimen counts. Because liner lymphatic channels existed between lymph nodes and the injected sites in all eleven patients, these lymphatic channels could be used as a guide for

  17. BrachyView: Proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Petasecca, M.; Loo, K. J.; Safavi-Naeini, M.; Han, Z.; Metcalfe, P. E.; Lerch, M. L. F.; Qi, Y.; Rosenfeld, A. B. [Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522 (Australia); Meikle, S. [Brain and Mind Research Institute, University of Sydney, NSW 2006, Australia and Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522 (Australia); Pospisil, S.; Jakubek, J. [Institute of Experimental and Applied Physics, Czech Technical University of Prague, Prague (Czech Republic); Bucci, J. A. [St George Cancer Care Centre, St George Hospital, Kogarah, NSW 2217 (Australia); Zaider, M. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 (United States)

    2013-04-15

    Purpose: The conformity of the achieved dose distribution to the treatment plan strongly correlates with the accuracy of seed implantation in a prostate brachytherapy treatment procedure. Incorrect seed placement leads to both short and long term complications, including urethral and rectal toxicity. The authors present BrachyView, a novel concept of a fast intraoperative treatment planning system, to provide real-time seed placement information based on in-body gamma camera data. BrachyView combines the high spatial resolution of a pixellated silicon detector (Medipix2) with the volumetric information acquired by a transrectal ultrasound (TRUS). The two systems will be embedded in the same probe so as to provide anatomically correct seed positions for intraoperative planning and postimplant dosimetry. Dosimetric calculations are based on the TG-43 method using the real position of the seeds. The purpose of this paper is to demonstrate the feasibility of BrachyView using the Medipix2 pixel detector and a pinhole collimator to reconstruct the real-time 3D position of low dose-rate brachytherapy seeds in a phantom. Methods: BrachyView incorporates three Medipix2 detectors coupled to a multipinhole collimator. Three-dimensionally triangulated seed positions from multiple planar images are used to determine the seed placement in a PMMA prostate phantom in real time. MATLAB codes were used to test the reconstruction method and to optimize the device geometry. Results: The results presented in this paper show a 3D position reconstruction accuracy of the seed in the range of 0.5-3 mm for a 10-60 mm seed-to-detector distance interval (Z direction), respectively. The BrachyView system also demonstrates a spatial resolution of 0.25 mm in the XY plane for sources at 10 mm distance from Medipix2 detector plane, comparable to the theoretical value calculated for an equivalent gamma camera arrangement. The authors successfully demonstrated the capability of BrachyView for real

  18. BrachyView: Proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy

    International Nuclear Information System (INIS)

    Purpose: The conformity of the achieved dose distribution to the treatment plan strongly correlates with the accuracy of seed implantation in a prostate brachytherapy treatment procedure. Incorrect seed placement leads to both short and long term complications, including urethral and rectal toxicity. The authors present BrachyView, a novel concept of a fast intraoperative treatment planning system, to provide real-time seed placement information based on in-body gamma camera data. BrachyView combines the high spatial resolution of a pixellated silicon detector (Medipix2) with the volumetric information acquired by a transrectal ultrasound (TRUS). The two systems will be embedded in the same probe so as to provide anatomically correct seed positions for intraoperative planning and postimplant dosimetry. Dosimetric calculations are based on the TG-43 method using the real position of the seeds. The purpose of this paper is to demonstrate the feasibility of BrachyView using the Medipix2 pixel detector and a pinhole collimator to reconstruct the real-time 3D position of low dose-rate brachytherapy seeds in a phantom. Methods: BrachyView incorporates three Medipix2 detectors coupled to a multipinhole collimator. Three-dimensionally triangulated seed positions from multiple planar images are used to determine the seed placement in a PMMA prostate phantom in real time. MATLAB codes were used to test the reconstruction method and to optimize the device geometry. Results: The results presented in this paper show a 3D position reconstruction accuracy of the seed in the range of 0.5–3 mm for a 10–60 mm seed-to-detector distance interval (Z direction), respectively. The BrachyView system also demonstrates a spatial resolution of 0.25 mm in the XY plane for sources at 10 mm distance from Medipix2 detector plane, comparable to the theoretical value calculated for an equivalent gamma camera arrangement. The authors successfully demonstrated the capability of BrachyView for

  19. Hydra phantom applicability for carrying out tests of field uniformity in gamma cameras; Aplicabilidade do fantoma hydra para realizacao dos testes de uniformidade de campo em gama camaras

    Energy Technology Data Exchange (ETDEWEB)

    Aragao Filho, Geraldo L., E-mail: geraldo_lemos10@hotmail.com [Centro de Medicina Nuclear de Pernambuco (CEMUPE), Recife, PE (Brazil); Oliveira, Alex C.H., E-mail: oliveira_ach@yahoo.com [Universidade Federal de Pernambuco (DEN/UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear; Lopes Filho, Ferdinand J.; Vieira, Jose W., E-mail: ferdinand.lopes@oi.com.br, E-mail: jose-wilson59@live.com [Instituto Federal de Pernambuco (IFPE), Recife, PE (Brazil)

    2014-07-01

    Nuclear Medicine is a medical modality that makes use of radioactive material 'in vivo' in humans, making them a temporary radioactive source. The radiation emitted by the patient's body is detected by a specific equipment, called a gamma camera, creates an image showing the spatial and temporal biodistribution of radioactive material administered to the patient. Therefore, it's of fundamental importance a number of specific measures to make sure that procedure be satisfactory, called quality control. To Nuclear Medicine, quality control of gamma camera has the purpose of ensuring accurate scintillographic imaging, truthful and reliable for the diagnosis, guaranteeing visibility and clarity of details of structures, and also to determine the frequency and the need for preventive maintenance of equipment. To ensure the quality control of the gamma camera it's necessary to use some simulators, called phantom, used in Nuclear Medicine to evaluate system performance, system calibration and simulation of injuries. The goal of this study was to validate a new simulator for nuclear medicine, the Hydra phantom. The phantom was initially built for construction of calibration curves used in radiotherapy planning and quality control in CT. It has similar characteristics to specific phantoms in nuclear medicine, containing inserts and water area. Those inserts are regionally sourced materials, many of them are already used in the literature and based on information about density and interaction of radiation with matter. To verify its efficiency in quality control in Nuclear Medicine, was performed a test for uniformity field, one of the main tests performed daily, so we can verify the ability of the gamma camera to reproduce a uniform distribution of the administered activity in the phantom, been analysed qualitatively, through the image, and quantitatively, through values established for Central Field Of View (CFOV) and Useful Field Of View (UFOV

  20. Development of the set of corrections for a gamma camera dedicated to research; Desarrollo del conjunto de correcciones para una gammacamara dedicada a investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Gimenez Insua, M.; Ambroa Rey, E. M.; Vazquez Vazquez, R.; Sanchez Garcia, M.; Luna Vega, V.; Mosquera Sueiro, J.; Otero Martinez, C.; Lobato Busto, R.; Pombar Camean, M.

    2013-07-01

    As part of a project for animal research, replaced electronics one of the gamma-cameras (GC) of the service that was out of use, with the aim of using it for SPECT. The implementation is therefore required of the corrections that allow image quality enough for SPECT from raw data supplied by the team. This has been developed software that enables to perform correction of power, uniform and linearity on the acquired data. For validation, change in several parameters indicative of the image quality has been evaluated. (Author)

  1. Imaging performance comparison between a LaBr3:Ce scintillator based and a CdTe semiconductor based photon counting compact gamma camera

    International Nuclear Information System (INIS)

    The authors report on the performance of two small field of view, compact gamma cameras working in single photon counting in planar imaging tests at 122 and 140 keV. The first camera is based on a LaBr3:Ce scintillator continuous crystal (49x49x5 mm3) assembled with a flat panel multianode photomultiplier tube with parallel readout. The second one belongs to the class of semiconductor hybrid pixel detectors, specifically, a CdTe pixel detector (14x14x1 mm3) with 256x256 square pixels and a pitch of 55 μm, read out by a CMOS single photon counting integrated circuit of the Medipix2 series. The scintillation camera was operated with selectable energy window while the CdTe camera was operated with a single low-energy detection threshold of about 20 keV, i.e., without energy discrimination. The detectors were coupled to pinhole or parallel-hole high-resolution collimators. The evaluation of their overall performance in basic imaging tasks is presented through measurements of their detection efficiency, intrinsic spatial resolution, noise, image SNR, and contrast recovery. The scintillation and CdTe cameras showed, respectively, detection efficiencies at 122 keV of 83% and 45%, intrinsic spatial resolutions of 0.9 mm and 75 μm, and total background noises of 40.5 and 1.6 cps. Imaging tests with high-resolution parallel-hole and pinhole collimators are also reported.

  2. Coincidence detection of photons of 511 keV from positon annihilation on a conventional gamma camera: optimization and analysis of potentialities

    International Nuclear Information System (INIS)

    The feasibility of acquiring clinical oncology studies on a gamma camera designed for the imaging of low energy single photons was investigated. The first prototype used two Nal(Tl) detectors of 40 cm by 30 cm with a 3/8 inch height and the second prototype was equipped with two large Nal(Tl) detectors of 40 cm by 54 cm with a 4/8 inch height. The optimization of such devices was mainly an optimization of the count rates obtained for reconstruct an image as a function of the angular axial aperture of the projections, with and without axial collimators. This optimization was performed experimentally using an anthropomorphic whole body phantom and the noise equivalent count rate as the figure of merit. An original correction for the random coincidences was also designed in order to optimize the contrast recovery and the contrast to noise ratio of small tumors (16 mm and 19 mm diameter). Finally, the optimal dose of FDG that can be injected to the subjects for an acquisition of that machine was determined and data acquired on an ECAT HR+ were compared with those acquired on the gamma camera for five subjects. (author)

  3. Initial evaluation of a modified dual-energy window scatter correction method for CZT-based gamma cameras for breast SPECT

    Science.gov (United States)

    Mann, Steve D.; Tornai, Martin P.

    2015-03-01

    Solid state Cadmium Zinc Telluride (CZT) gamma cameras for SPECT imaging offer significantly improved energy resolution compared to traditional scintillation detectors. However, the photopeak resolution is often asymmetric due to incomplete charge collection within the detector, resulting in many photopeak events incorrectly sorted into lower energy bins ("tailing"). These misplaced events contaminate the true scatter signal, which may negatively impact scatter correction methods that rely on estimates of scatter from the spectra. Additionally, because CZT detectors are organized into arrays, each individual detector element may exhibit different degrees of tailing. Here, we present a modified dualenergy window scatter correction method for emission detection and imaging that attempts to account for positiondependent effects of incomplete charge collection in the CZT gamma camera of our dedicated breast SPECT-CT system. Point source measurements and geometric phantoms were used to estimate the impact of tailing on the scatter signal and extract a better estimate of the ratio of scatter within two energy windows. To evaluate the method, cylindrical phantoms with and without a separate fillable chamber were scanned to determine the impact on quantification in hot, cold, and uniform background regions. Projections were reconstructed using OSEM, and the results for the traditional and modified scatter correction methods were compared. Results show that while modest reduced quantification accuracy was observed in hot and cold regions of the multi-chamber phantoms, the modified scatter correction method yields up to 8% improved quantification accuracy with 4% less added noise than the traditional DEW method within uniform background regions.

  4. Unilateral effective renal plasma flow measurement using one-compartment analysis of 99mTc-MAG3 and gamma-camera renography

    International Nuclear Information System (INIS)

    The aim of this study was to establish a simple and accurate procedure to calculate the unilateral effective renal plasma flow (ERPF) using 99mTc-MAG3 gamma-camera renography. Eleven patients with urological disorders were studied with 99mTc-MAG3 to calculate the renal uptake ratio (RUR), which was defined as the ratio of absorption-corrected renal counts within 1-2 min after intravenous injection to injection radioactivity measured with a gamma-camera. We assumed that 99mTc-MAG3 was distributed in the circulation, moved from the circulation to the kidneys, and was excreted solely from the kidneys. We thus adopted an one-compartment model to calculate 99mTc-MAG3 clearance (CLMAG) using RUR. Sequential p-aminohippurate (PAH) clearance study was performed as a gold standard in all the patients to compare CLMAG and PAH clearance. Obtained CLMAG correlated well with PAH clearance, and this one-compartment model seemed appropriate for describing CLMAG. Unilateral ERPF was accurately measured within two minutes after the intravenous injection of 99mTc-MAG3 in conjunction with the renal imaging study. This procedure is simple and reliable, and requires no blood or urine sampling. (author)

  5. Use of calibration methodology of gamma cameras for the workers surveillance using a thyroid simulator; Uso de una metodologia de calibracion de camaras gamma para la vigilancia de trabajadores usando un simulador de tiroides

    Energy Technology Data Exchange (ETDEWEB)

    Alfaro, M.; Molina, G.; Vazquez, R.; Garcia, O., E-mail: mercedes.alfaro@inin.gob.m [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-09-15

    In Mexico there are a significant number of nuclear medicine centers in operation. For what the accidents risk related to the transport and manipulation of open sources used in nuclear medicine can exist. The National Institute of Nuclear Research (ININ) has as objective to establish a simple and feasible methodology for the workers surveillance related with the field of the nuclear medicine. This radiological surveillance can also be applied to the public in the event of a radiological accident. To achieve this it intends to use the available equipment s in the nuclear medicine centers, together with the neck-thyroid simulators elaborated by the ININ to calibrate the gamma cameras. The gamma cameras have among their component elements that conform spectrometric systems like the employees in the evaluation of the internal incorporation for direct measurements, reason why, besides their use for diagnostic for image, they can be calibrated with anthropomorphic simulators and also with punctual sources for the quantification of the radionuclides activity distributed homogeneously in the human body, or located in specific organs. Inside the project IAEA-ARCAL-RLA/9/049-LXXVIII -Procedures harmonization of internal dosimetry- where 9 countries intervened (Argentina, Brazil, Colombia, Cuba, Chile, Mexico, Peru, Uruguay and Spain). It was developed a protocol of cameras gamma calibration for the determination in vivo of radionuclides. The protocol is the base to establish and integrated network in Latin America to attend in response to emergencies, using nuclear medicine centers of public hospitals of the region. The objective is to achieve the appropriate radiological protection of the workers, essential for the sure and acceptable radiation use, the radioactive materials and the nuclear energy. (Author)

  6. Development of a tomographic system adapted to 3D measurement of contaminated wounds based on the Cacao concept (Computer aided collimation Gamma Camera)

    International Nuclear Information System (INIS)

    The computer aided collimation gamma camera (CACAO in French) is a gamma camera using a collimator with large holes, a supplementary linear scanning motion during the acquisition and a dedicated reconstruction program taking full account of the source depth. The CACAO system was introduced to improve both the sensitivity and the resolution in nuclear medicine. This thesis focuses on the design of a fast and robust reconstruction algorithm in the CACAO project. We start by an overview of tomographic imaging techniques in nuclear medicine. After modelling the physical CACAO system, we present the complete reconstruction program which involves three steps: 1) shift and sum 2) deconvolution and filtering 3) rotation and sum. The deconvolution is the critical step that decreases the signal to noise ratio of the reconstructed images. We propose a regularized multi-channel algorithm to solve the deconvolution problem. We also present a fast algorithm based on Splines functions and preserving the high quality of the reconstructed images for the shift and the rotation steps. Comparisons of simulated reconstructed images in 2D and 3D for the conventional system (CPHC) and CACAO demonstrate the ability of CACAO system to increase the quality of the SPECT images. Finally, this study concludes with an experimental approach with a pixellated detector conceived for a 3D measurement of contaminated wounds. This experimentation proves the possible advantages of coupling the CACAO project with pixellated detectors. Moreover, a variety of applications could fully benefit from the CACAO system, such as low activity imaging, the use of high-energy gamma isotopes and the visualization of deep organs. Moreover the combination of the CACAO system with a pixels detector may open up further possibilities for the future of nuclear medicine. (author)

  7. A compact, discrete CsI(Tl) scintillator/Si photodiode gamma camera for breast cancer imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gruber, Gregory J.

    2000-12-01

    Recent clinical evaluations of scintimammography (radionuclide breast imaging) are promising and suggest that this modality may prove a valuable complement to X-ray mammography and traditional breast cancer detection and diagnosis techniques. Scintimammography, however, typically has difficulty revealing tumors that are less than 1 cm in diameter, are located in the medial part of the breast, or are located in the axillary nodes. These shortcomings may in part be due to the use of large, conventional Anger cameras not optimized for breast imaging. In this thesis I present compact single photon camera technology designed specifically for scintimammography which strives to alleviate some of these limitations by allowing better and closer access to sites of possible breast tumors. Specific applications are outlined. The design is modular, thus a camera of the desired size and geometry can be constructed from an array (or arrays) of individual modules and a parallel hole lead collimator for directional information. Each module consists of: (1) an array of 64 discrete, optically-isolated CsI(Tl) scintillator crystals 3 x 3 x 5 mm{sup 3} in size, (2) an array of 64 low-noise Si PIN photodiodes matched 1-to-1 to the scintillator crystals, (3) an application-specific integrated circuit (ASIC) that amplifies the 64 photodiode signals and selects the signal with the largest amplitude, and (4) connectors and hardware for interfacing the module with a motherboard, thereby allowing straightforward computer control of all individual modules within a camera.

  8. A compact, discrete CsI(Tl) scintillator/Si photodiode gamma camera for breast cancer imaging

    International Nuclear Information System (INIS)

    Recent clinical evaluations of scintimammography (radionuclide breast imaging) are promising and suggest that this modality may prove a valuable complement to X-ray mammography and traditional breast cancer detection and diagnosis techniques. Scintimammography, however, typically has difficulty revealing tumors that are less than 1 cm in diameter, are located in the medial part of the breast, or are located in the axillary nodes. These shortcomings may in part be due to the use of large, conventional Anger cameras not optimized for breast imaging. In this thesis I present compact single photon camera technology designed specifically for scintimammography which strives to alleviate some of these limitations by allowing better and closer access to sites of possible breast tumors. Specific applications are outlined. The design is modular, thus a camera of the desired size and geometry can be constructed from an array (or arrays) of individual modules and a parallel hole lead collimator for directional information. Each module consists of: (1) an array of 64 discrete, optically-isolated CsI(Tl) scintillator crystals 3 x 3 x 5 mm3 in size, (2) an array of 64 low-noise Si PIN photodiodes matched 1-to-1 to the scintillator crystals, (3) an application-specific integrated circuit (ASIC) that amplifies the 64 photodiode signals and selects the signal with the largest amplitude, and (4) connectors and hardware for interfacing the module with a motherboard, thereby allowing straightforward computer control of all individual modules within a camera

  9. "Positron tomography of breast cancer in a community hospital: A case study of advanced disease using a coincidence Gamma camera "

    OpenAIRE

    "Cohen P; Sossi V; Ruth T; Johnson RR; Lyster D; Mankoff D

    1999-01-01

    Until recently PET scanning has been available only at major universities or teaching hospitals possessing the necessary resources and expertise to operate a research PET facility. Most dedicated PET centers cost several millions of dollars, and include a cyclotron, a radiochemistry laboratory to synthesize PET radiopharmaceuticals, a multicrystal dedicated PET camera, advanced computer facilities and a staff of many researchers, radiochemists, physicists, computer programmers, physicians and...

  10. The next evolution in radioguided surgery: breast cancer related sentinel node localization using a freehandSPECT-mobile gamma camera combination.

    Science.gov (United States)

    Engelen, Thijs; Winkel, Beatrice Mf; Rietbergen, Daphne Dd; KleinJan, Gijs H; Vidal-Sicart, Sergi; Olmos, Renato A Valdés; van den Berg, Nynke S; van Leeuwen, Fijs Wb

    2015-01-01

    Accurate pre- and intraoperative identification of the sentinel node (SN) forms the basis of the SN biopsy procedure. Gamma tracing technologies such as a gamma probe (GP), a 2D mobile gamma camera (MGC) or 3D freehandSPECT (FHS) can be used to provide the surgeon with radioguidance to the SN(s). We reasoned that integrated use of these technologies results in the generation of a "hybrid" modality that combines the best that the individual radioguidance technologies have to offer. The sensitivity and resolvability of both 2D-MGC and 3D-FHS-MGC were studied in a phantom setup (at various source-detector depths and using varying injection site-to-SN distances), and in ten breast cancer patients scheduled for SN biopsy. Acquired 3D-FHS-MGC images were overlaid with the position of the phantom/patient. This augmented-reality overview image was then used for navigation to the hotspot/SN in virtual-reality using the GP. Obtained results were compared to conventional gamma camera lymphoscintigrams. Resolution of 3D-FHS-MGC allowed identification of the SNs at a minimum injection site (100 MBq)-to-node (1 MBq; 1%) distance of 20 mm, up to a source-detector depth of 36 mm in 2D-MGC and up to 24 mm in 3D-FHS-MGC. A clinically relevant dose of approximately 1 MBq was clearly detectable up to a depth of 60 mm in 2D-MGC and 48 mm in 3D-FHS-MGC. In all ten patients at least one SN was visualized on the lymphoscintigrams with a total of 12 SNs visualized. 3D-FHS-MGC identified 11 of 12 SNs and allowed navigation to all these visualized SNs; in one patient with two axillary SNs located closely to each other (11 mm), 3D-FHS-MGC was not able to distinguish the two SNs. In conclusion, high sensitivity detection of SNs at an injection site-to-node distance of 20 mm-and-up was possible using 3D-FHS-MGC. In patients, 3D-FHS-MGC showed highly reproducible images as compared to the conventional lymphoscintigrams. PMID:26069857

  11. Uteroplacental blood flow in pre-eclampsia measurements with /sup 113 m/In and a computer-linked gamma camera

    International Nuclear Information System (INIS)

    Uteroplacental blood flow was measured with a computer-linked gamma camera after intravenous injection of 1 mCi 113In. Results of the measurements from 32 pre-eclamptic pregnancies and 37 normal controls are compared. The uteroplacental blood flow was measured as an index calculated from the rise time and maximum activity of the isotope accumulation curve. The uteroplacental blood flow was reduced with 50% in pre-eclampsia. In severe pre-eclampsia it was more compromised than in mild pre-eclampsia. A diminished uteroplacental blood flow was found in pre-eclampsia even in the absence of intrauterine growth retardation. The maternal placental circulation in the supine position was reduced with one third compared to that in the left lateral recumbent position

  12. Radiopharmaceutical activities administered for diagnostic procedures in nuclear medicine in the first six months of the gamma camera use in the Clinical Center of Montenegro - Podgorica

    International Nuclear Information System (INIS)

    Nuclear medicine procedures have carried out in the Clinical Center of Montenegro - Podgorica since 2006 by the dual-headed SPECT and Digital gamma camera NUCLINE Spirit DH-V. In the first six months of the gamma camera use (from September 2006 to March 2007) examinations of skeleton, kidneys, thyroid and lung were performed. For diagnostic skeletal imaging (102 patients) the radiopharmaceutical 99mTc-MDP is used, and administered activities were in the range from 555 to 740 MBq. For thyroid imaging (203 patients) 99mTc-pertechnetate is used, and administered activities were in the range (37-111) MBq. Lung imaging is performed for 3 patients, using 99mTc-MAA and administered activities in the range (111-185) MBq. Renal imaging is carried out for 72 patients: 42 dynamic studies of kidneys were performed with 99mTc-DTPA and administered activities from 207 to 282 MBq, and 30 static kidneys scintigraphies were performed using the radiopharmaceutical 99mTc-DMSA. 6 patients in the last mentioned group were children with year of birth between 2000 and 2006, and administered activities were from 16.6 to 55.5 MBq. In the same group, activities 28.5 MBq, 74.4 MBq and 120 MBq were administered to three patients with age between 6 and 18 years, and in the other cases, administered activities to the patients (adults) were in the range (59.2 to 196) MBq. The administered activities presented here are basis for further estimations of cumulated activity and absorbed dose to the various organs, which is useful for comparison of the average dose to patient organs in various nuclear medicine procedures and calculation of effective dose equivalent and total effective dose, significant for an estimation of potential risk due to the radioactivity administered to a patient during nuclear medicine procedures. It is very important for procedures optimization and improvement of the radiation protection. (author)

  13. High-resolution mini gamma camera for diagnosis and radio-guided surgery in diabetic foot infection

    International Nuclear Information System (INIS)

    The diagnosis of diabetic foot osteomyelitis is often difficult. 99mTc-WBC (White Blood Cell) scintigraphy plays a key role in the diagnosis of bone infections. Spatial resolution of Anger camera is not always able to differentiate soft tissue from bone infection. Aim of present study is to verify if HRD (High-Resolution Detector) is able to improve diagnosis and to help surgery. Patients were studied by HRD showing 25.7x25.7 mm2 FOV, 2 mm spatial resolution and 18% energy resolution. The patients were underwent to surgery and, when necessary, bone biopsy, both guided by HRD. Four patients were positive at Anger camera without specific signs of osteomyelitis. HRS (High-Resolution Scintigraphy) showed hot spots in the same patients. In two of them the hot spot was bar-shaped and it was localized in correspondence of the small phalanx. The presence of bone infection was confirmed at surgery, which was successfully guided by HRS. 99mTc-WBC HRS was able to diagnose pedal infection and to guide the surgery of diabetic foot, opening a new way in the treatment of infected diabetic foot

  14. High-resolution mini gamma camera for diagnosis and radio-guided surgery in diabetic foot infection

    Science.gov (United States)

    Scopinaro, F.; Capriotti, G.; Di Santo, G.; Capotondi, C.; Micarelli, A.; Massari, R.; Trotta, C.; Soluri, A.

    2006-12-01

    The diagnosis of diabetic foot osteomyelitis is often difficult. 99mTc-WBC (White Blood Cell) scintigraphy plays a key role in the diagnosis of bone infections. Spatial resolution of Anger camera is not always able to differentiate soft tissue from bone infection. Aim of present study is to verify if HRD (High-Resolution Detector) is able to improve diagnosis and to help surgery. Patients were studied by HRD showing 25.7×25.7 mm 2 FOV, 2 mm spatial resolution and 18% energy resolution. The patients were underwent to surgery and, when necessary, bone biopsy, both guided by HRD. Four patients were positive at Anger camera without specific signs of osteomyelitis. HRS (High-Resolution Scintigraphy) showed hot spots in the same patients. In two of them the hot spot was bar-shaped and it was localized in correspondence of the small phalanx. The presence of bone infection was confirmed at surgery, which was successfully guided by HRS. 99mTc-WBC HRS was able to diagnose pedal infection and to guide the surgery of diabetic foot, opening a new way in the treatment of infected diabetic foot.

  15. High-resolution mini gamma camera for diagnosis and radio-guided surgery in diabetic foot infection

    Energy Technology Data Exchange (ETDEWEB)

    Scopinaro, F. [Department of Radiological Sciences, University ' La Sapienza' Rome (Italy); Capriotti, G. [Department of Radiological Sciences, University ' La Sapienza' Rome (Italy); Di Santo, G. [Department of Radiological Sciences, University ' La Sapienza' Rome (Italy); Capotondi, C. [Unit of Radiology, S. Andrea Hospital, Rome (Italy); Micarelli, A. [Nuclear Medicine, Sulmona Hospital, Sulmona (AQ) (Italy); Massari, R. [Institute of Biomedical Engineering, ISIB-CNR, Rome-Li-tech srl, Lauzacco Pavia di Udine (UD) (Italy); Trotta, C. [Institute of Biomedical Engineering, ISIB-CNR, Rome-Li-tech srl, Lauzacco Pavia di Udine (UD) (Italy); Soluri, A. [Institute of Biomedical Engineering, ISIB-CNR, Rome-Li-tech srl, Lauzacco Pavia di Udine (UD) (Italy)]. E-mail: soluri@isib.cnr.it

    2006-12-20

    The diagnosis of diabetic foot osteomyelitis is often difficult. {sup 99m}Tc-WBC (White Blood Cell) scintigraphy plays a key role in the diagnosis of bone infections. Spatial resolution of Anger camera is not always able to differentiate soft tissue from bone infection. Aim of present study is to verify if HRD (High-Resolution Detector) is able to improve diagnosis and to help surgery. Patients were studied by HRD showing 25.7x25.7 mm{sup 2} FOV, 2 mm spatial resolution and 18% energy resolution. The patients were underwent to surgery and, when necessary, bone biopsy, both guided by HRD. Four patients were positive at Anger camera without specific signs of osteomyelitis. HRS (High-Resolution Scintigraphy) showed hot spots in the same patients. In two of them the hot spot was bar-shaped and it was localized in correspondence of the small phalanx. The presence of bone infection was confirmed at surgery, which was successfully guided by HRS. {sup 99m}Tc-WBC HRS was able to diagnose pedal infection and to guide the surgery of diabetic foot, opening a new way in the treatment of infected diabetic foot.

  16. Extensive testing of Schottky CdTe detectors for the ECLAIRs X-Gamma-ray Camera on board the SVOM mission

    CERN Document Server

    Nadege, Remoue; Olivier, Godet; Pierre, Mandrou

    2010-01-01

    We report on an on-going test campaign of more than 5000 Schottky CdTe detectors (4x4x1 mm^3), over a sample of twelve thousands, provided by Acrorad Co., Ltd (Japan). 6400 of these detectors will be used to build the detection plane of the ECLAIRs camera on the Chinese-French gamma-ray burst mission SVOM. These tests are mandatory to fulfill the prime requirement of ECLAIRs to detect gamma-ray burst photons down to 4 keV. The detectors will be operated at -20C under a reverse bias of 600 V. We found that 78% of the detectors already tested could be considered for the flight model. We measured a mean energy resolution of 1.8 keV at 59.6 keV. We investigated the polarization effect first at room temperature and low bias voltage for faster analysis. We found that the spectroscopic degradation in quantum efficiency, gain and energy resolution, starts as soon as the bias is turned on: first slowly and then dramatically after a time t_p which depends on the temperature and the voltage value. Preliminary tests unde...

  17. Development of a Compton Camera for Online Range Monitoring of Laser-Accelerated Proton Beams via Prompt-Gamma Detection

    Directory of Open Access Journals (Sweden)

    Thirolf P.G.

    2014-03-01

    Full Text Available Presently large efforts are conducted in Munich towards the development of proton beams for bio-medical applications, generated via the technique of particle acceleration from high-power, short-pulse lasers. While so far mostly offline diagnostics tools are used in this context, we aim at developing a reliable and accurate online range monitoring technique, based on the position-sensitive detection of prompt γ rays emitted from nuclear reactions between the proton beam and the biological sample. For this purpose, we develop a Compton camera, designed to be able to track not only the Compton scattering of the primary photon, but also to detect the secondary Compton electron, thus reducing the Compton cone to an arc segment and by this increasing the source reconstruction efficiency. Design specifications and the status of the protype system are discussed.

  18. Myocardial perfusion imaging with a cadmium zinc telluride-based gamma camera versus invasive fractional flow reserve

    International Nuclear Information System (INIS)

    Recently introduced ultrafast cardiac SPECT cameras with cadmium zinc telluride-based (CZT) detectors may provide superior image quality allowing faster acquisition with reduced radiation doses. Although the level of concordance between conventional SPECT and invasive fractional flow reserve (FFR) measurement has been studied, that between FFR and CZT-based SPECT is not yet known. Therefore, we aimed to assess the level of concordance between CZT SPECT and FFR in a large patient group with stable coronary artery disease. Both invasive FFR and myocardial perfusion imaging with a CZT-based SPECT camera, using Tc-tetrofosmin as tracer, were performed in 100 patients with stable angina and intermediate grade stenosis on invasive coronary angiography. A cut-off value of <0.75 was used to define abnormal FFR. The mean age of the patients was 64 ± 11 years, and 64 % were men. SPECT demonstrated ischaemia in 31 % of the patients, and 20 % had FFR <0.75. The concordance between CZT SPECT and FFR was 73 % on a per-patient basis and 79 % on a per-vessel basis. Discordant findings were more often seen in older patients and were mainly (19 %) the result of ischaemic SPECT findings in patients with FFR ≥0.75, whereas only 8 % had an abnormal FFR without ischaemia as demonstrated by CZT SPECT. Only 20 - 30 % of patients with intermediate coronary stenoses had significant ischaemia as assessed by CZT SPECT or invasive FFR. CZT SPECT showed a modest degree of concordance with FFR, which is comparable with previous results with conventional SPECT. Further investigations are particularly necessary in patients with normal SPECT and abnormal FFR, especially to determine whether these patients should undergo revascularization. (orig.)

  19. Myocardial perfusion imaging with a cadmium zinc telluride-based gamma camera versus invasive fractional flow reserve

    Energy Technology Data Exchange (ETDEWEB)

    Mouden, Mohamed [Isala klinieken, Department of Cardiology, Zwolle (Netherlands); Isala klinieken, Department of Nuclear Medicine, Zwolle (Netherlands); Ottervanger, Jan Paul; Timmer, Jorik R. [Isala klinieken, Department of Cardiology, Zwolle (Netherlands); Knollema, Siert; Reiffers, Stoffer; Oostdijk, Ad H.J.; Jager, Pieter L. [Isala klinieken, Department of Nuclear Medicine, Zwolle (Netherlands); Boer, Menko-Jan de [University Medical Centre Nijmegen, Department of Cardiology, Nijmegen (Netherlands)

    2014-05-15

    Recently introduced ultrafast cardiac SPECT cameras with cadmium zinc telluride-based (CZT) detectors may provide superior image quality allowing faster acquisition with reduced radiation doses. Although the level of concordance between conventional SPECT and invasive fractional flow reserve (FFR) measurement has been studied, that between FFR and CZT-based SPECT is not yet known. Therefore, we aimed to assess the level of concordance between CZT SPECT and FFR in a large patient group with stable coronary artery disease. Both invasive FFR and myocardial perfusion imaging with a CZT-based SPECT camera, using Tc-tetrofosmin as tracer, were performed in 100 patients with stable angina and intermediate grade stenosis on invasive coronary angiography. A cut-off value of <0.75 was used to define abnormal FFR. The mean age of the patients was 64 ± 11 years, and 64 % were men. SPECT demonstrated ischaemia in 31 % of the patients, and 20 % had FFR <0.75. The concordance between CZT SPECT and FFR was 73 % on a per-patient basis and 79 % on a per-vessel basis. Discordant findings were more often seen in older patients and were mainly (19 %) the result of ischaemic SPECT findings in patients with FFR ≥0.75, whereas only 8 % had an abnormal FFR without ischaemia as demonstrated by CZT SPECT. Only 20 - 30 % of patients with intermediate coronary stenoses had significant ischaemia as assessed by CZT SPECT or invasive FFR. CZT SPECT showed a modest degree of concordance with FFR, which is comparable with previous results with conventional SPECT. Further investigations are particularly necessary in patients with normal SPECT and abnormal FFR, especially to determine whether these patients should undergo revascularization. (orig.)

  20. Computer aided collimation gamma (Cacao): a new approach in measuring and visualizing the distribution of X and gamma ray emitters in contaminate wounds; Cacao (camera a collimation assistee par ordinateur): une nouvelle approche pour reconstruire et visualiser des contaminations d'emetteurs X et gamma dans les blessures

    Energy Technology Data Exchange (ETDEWEB)

    Douiri, A. [Hopital Pitie-Salpetriere (LENA), 75 - Paris (France); Jeanguillaume, C. [Centre Hospitalier Universitaire de Larrey, Service de Medecine Nucleaire, 49 - Angers (France); Franck, D.; Carlan, L. de [Institut de Radioprotection et de Surete Nucleaire, IRSN, Dept. de Protection de la Sante de l' Homme et de Dosimetrie, 92 - Fontenay aux Roses (France); Quartuccio, M.; Begot, S. [Faculte des Sciences d' Orsay (LPS), 91 - Orsay (France)

    2003-07-01

    The treatment of contaminated wounds can be greatly improved by visualizing the distribution of the radioactivity that is present. The low sensitivity of the conventional Anger camera means that it can only be used where there is a high level of activity. Moreover, these gamma cameras cannot make full use of the recent progress made in high spatial resolution semi-conductor detectors. In order to increase sensitivity while at the same time maintaining a sufficient resolution of the reconstructed image, the principle of the Computer aided collimation gamma camera (CACAO in French) was proposed as a possible means of using gamma cameras in intern dosimetry. This principle is based on the combined use of collimators with holes that are wider- than the intrinsic resolution of the detector, circular and linear scanning movements, a detector sensitive to the source depth and a specific reconstruction algorithm. This article presents the recent developments of the CACAO system and illustrates by a theoretical and experimental study, its performances compared with the classic tomography system. We start with a general overview of the CACAO system and its reconstruction algorithm. First of all, the superiority of the CACAO system is demonstrated by a simulation ,study. Then, an experimental bench was developed using an implanted silicon pixel detector specifically designed to allow the visualization of a subject contaminated with low energy X and gamma emitters. The study presented here shows images obtained from a phantom composed of three sources of Americium {sup 341}Am. Although the comparison between the conventional and CACAO approaches were not carried out with optimal parameters, especially for CACAO, the initial results show that CACAO has an improved sensitivity and a superior resolution. Finally, the transposition of this system to the practical study of contaminated wounds is discussed. (authors)

  1. Application of Two Phase (Liquid/Gas) Xenon Gamma-Camera for the Detection of Special Nuclear Material and PET Medical Imaging

    Energy Technology Data Exchange (ETDEWEB)

    McKinsey, Daniel Nicholas [Yale University

    2013-08-27

    The McKinsey group at Yale has been awarded a grant from DTRA for the building of a Liquid Xenon Gamma Ray Color Camera (LXe-GRCC), which combines state-of-the-art detection of LXe scintillation light and time projection chamber (TPC) charge readout. The DTRA application requires a movable detector and hence only a single phase (liquid) xenon detector can be considered in this case. We propose to extend the DTRA project to applications that allow a two phase (liquid/gas) xenon TPC. This entails additional (yet minimal) hardware and extension of the research effort funded by DTRA. The two phase detector will have better energy and angular resolution. Such detectors will be useful for PET medical imaging and detection of special nuclear material in stationary applications (e.g. port of entry). The expertise of the UConn group in gas phase TPCs will enhance the capabilities of the Yale group and the synergy between the two groups will be very beneficial for this research project as well as the education and research projects of the two universities. The LXe technology to be used in this project has matured rapidly over the past few years, developed for use in detectors for nuclear physics and astrophysics. This technology may now be applied in a straightforward way to the imaging of gamma rays. According to detailed Monte Carlo simulations recently performed at Yale University, energy resolution of 1% and angular resolution of 3 degrees may be obtained for 1.0 MeV gamma rays, using existing technology. With further research and development, energy resolution of 0.5% and angular resolution of 1.3 degrees will be possible at 1.0 MeV. Because liquid xenon is a high density, high Z material, it is highly efficient for scattering and capturing gamma rays. In addition, this technology scales elegantly to large detector areas, with several square meter apertures possible. The Yale research group is highly experienced in the development and use of noble liquid detectors for

  2. The regional exploration of pulmonary function using xenon 133. Value of the gamma camera connected to a computer

    International Nuclear Information System (INIS)

    Regional isotopic exploration of ventilation and pulmonary perfusion is not yet widely applied in clinical practice, by virtue of the complexity of the equipment required, but also because of the complicated and lengthy analysis of the results. In this respect, connection of the scintillation camera to a computer represents a major advance which other authors have already emphasized. Our own experience in this area and our method of exploration in a group of 43 cases of chronic obstructive lung disease (33 patients of the chronic bronchitis type, 10 patients with emphysema) are analysed and discussed. The results indicate the following: in chronic bronchitis, a very marked fall in ventilation of the bases with inversion of the normal vertical ventilation gradient, and a fall in the ventilation/perfusion ratio of the bases; in emphysema, a fall in ventilation, but also and above all in regional perfusion of all territories with preservation of normal or even increased regional ventilation/perfusion ratios. Regional exploration may also be of value in the detection of early stages of obstructive lung disease, and in pre-operative assessment in thoracic surgery

  3. Attenuation coefficients for Tc-99m photons in water-filled phantoms, determined with a gamma camera: Variation with energy window

    International Nuclear Information System (INIS)

    Values of the linear attenuation coefficient, μ, near 0.12 cm/sup -1/ used in attenuation compensation of Tc-99m ECT scans of uniform cylindrical phantoms give better results than use of 0.15 cm/sup -1/. The latter value is theoretical, and does not take into account recoil photons from Compton scattering, but continues to be used in new SPECT software development and other quantitative imaging situations. To investigate the influence of Compton scattering on the effective linear attenuation coefficient, a gamma camera and a multichannel pulse height analyzer were used to determine values of μ for photons in water as a function of energy window, using the entire camera field as a region of interest. Two cylindrical water-filled phantom, circular (22 cm O.D.) and elliptical (22.5 x 30.5 cm O.D.) were used with point sources of Tc-99m at depths up to 21 cm. Energy spectrum data were integrated over: top half of photopeak, 10%, 20% and 30% centered windows and bottom half of photopeak. Almost all attenuation plots were exponential, with highest values of μ (0.122 to 0.128 cm/sup -1/ at top half of photopeak, and with μ decreasing as the energy threshold was lowered (0.117-0.116, 0.108-0.106, 0.105-0.097, and 0.100-0.091 cm/sup -1/ for windows noted above, for circular and elliptical (short axis) phantoms, respectively). This variation with energy window suggests that there is within the ''photopeak'' a distribution of scattered photons the magnitude of which increases with decreasing energy, and accounts for improved attenuation corrections with values of μ less than the theoretical 0.15 cm/sup -1/

  4. Development and performance evaluation of an animal SPECT system using Philips ARGUS gamma camera and pinhole collimators

    International Nuclear Information System (INIS)

    We developed an animal SPECT system using clinical Philips ARGUS scintillation camera, pinhole collimator with specially manufactured small apertures and laser alignment system to minimize center of rotation error. In this study, we evaluated the physical characteristics of this system and biological feasibility for animal experiments. Rotating station for small animals using a step motor and laser alignment system were developed. Pinhole inserts with small apertures (0.5, 1.0, and 2.0 mm) were manufactured and physical parameters including planar and reconstructed spatial resolution and sensitivity were measured for some apertures. Using manufactured multiple line sources; the size of usable field of view was measured. Using a Tc-99m line source with 0.5 mm diameter placed in the exact center of field of view, planar spatial resolution according to the distance was measured. Calibration factor to obtain FWHM values in mm unit was calculated from the planar image of two separated line sources. Tc-99m point source with 1 mm diameter was used for the measurement of system sensitivity. In addition, SPECT data of micro phantom with cold inserts and rat brain after intravenous injection of [I-123]FP-CIT were acquired using laser alignment system and reconstructed using filtered back projection and ordered subsets expectation maximization reconstruction algorithm. Size of usable field of view was proportional to the distance and that could be fitted into a linear equation.(y=1.4x+0.5 x:distance) System sensitivity and planar spatial resolution at 3 cm measured using 1.0 mm aperture was 71 cps/MBq and 1.24 mm, respectively. In the SPECT image of rat brain the distribution of dopamine transporter in the striatum was well identified in each hemisphere. We verified that this new animal SPECT system with the Philips ARGUS scanner and small apertures had sufficient performance for small animal imaging

  5. Development and performance evaluation of an animal SPECT system using Philips ARGUS gamma camera and pinhole collimator

    International Nuclear Information System (INIS)

    We developed an animal SPECT system using clinical Philips ARGUS scintillation camera and pinhole collimator with specially manufactured small apertures. In this study, we evaluated the physical characteristics of this system and biological feasibility for animal experiments. Rotating station for small animals using a step motor and operating software were developed. Pinhole inserts with small apertures (diameter of 0.5, 1.0, and 2.0 mm) were manufactured and physical parameters including planar spatial resolution and sensitivity and reconstructed resolution were measured for some apertures. In order to measure the size of the usable field of view according to the distance from the focal point, manufactured multiple line sources separated with the same distance were scanned and numbers of lines within the field of view were counted. Using a Tc-99m line source with 0.5 mm diameter and 12 mm length placed in the exact center of field of view, planar spatial resolution according to the distance was measured. Calibration factor to obtain FWHM values in 'mm' unit was calculated from the planar image of two separated line sources. Tc-99m point source with 1 mm diameter was used for the measurement of system sensitivity. In addition, SPECT data of micro phantom with cold and hot line inserts and rat brain after intravenous injection of [I-123]FP-CIT were acquired and reconstructed using filtered back projection reconstruction algorithm for pinhole collimator. Size of usable field of view was proportional to the distance from the focal point and their relationship could be fitted into a linear equation (y=1,4x + 0.5, x: distance). System sensitivity and planar spatial resolution at 3 cm measured using 1.0 mm aperture was 71 cps/MBq and 1.24 mm, respectively. In the SPECT image of rat brain with [I-123]FP-CIT acquired using 1.0 mm aperture, the distribution of dopamine transporter in the striatum was well identified in each hemisphere. We verified that this new animal SPECT

  6. Surface and volume three-dimensional displays of Tc-99m HMPAO brain SPECT images in stroke patients with three-head gamma camera

    International Nuclear Information System (INIS)

    This paper evaluates volume and surface 3D displays in Tc-99m HMPAO brain SPECT imaging in stroke patients. Using a triple-head gamma camera interfaced with a 64-bit supercomputer, 20 patients with stroke were studied. Each patient was imaged 30-60 minutes after an intravenous injection of 20 mCi of Tc-99m HMPAO. SPECT images as well as planar images were routinely obtained; volume and surface 3D display then proceeded, with the process requiring 5-10 minutes. Volume and surface 3D displays show the brain from all angles; thus the location and extension of lesion(s) in the brain are much easier to appreciate. While a cerebral lesion(s) was more clearly delineated by surface 3D imaging, crossed cerebellar diaschisis in seven patients was clearly exhibited with volume 3D but not with surface 3D imaging. Volume and surface 3D displays enhance continuity of structures and understanding of spatial relationships

  7. Comparison of uteroplacental blood flow in normal and pre-eclamptic patients measurement with technetium-99m and a computer-linked gamma camera

    International Nuclear Information System (INIS)

    Uteroplacental blood flow studies in preeclampsia are of special interest since the vascular changes reported in this disease might constitute a structural basis for a reduction of blood flow. Evidence has also been given for a decreased uteroplacental blood flow in preeclampsia. Among the various methods to estimate the maternal placental blood flow, the one most frequently reported in the literature during the last years has been the time activity analysis of short lived radiotracer such as technetium-99m or indium-113m injected intravenously. Only few studies with the above mentioned technique comparing normal and preeclampsia cases have been undertaken. In clinical practice we frequently experience difficuly in finding the optimal time to get the delivery in preeclampsia patients. The aim of this study was first to measure uteroplacental blood flow in preeclamptic pregnancies using a computer-linked gamma camera method for the time-activity analysis of technetium-99m and second to discuss the possibility of clinical application of these measurements for determination of fetal well-being and the timing of the delivery in these patients. Uteroplacental blood flow was measured from 13 preeclamptic patients and 19 pregnancies without any complication after 35 completed weeks of gestation from Jan. 1983 to Sep. 1983 at Obstetrics department of Hanyang University Hospital. (Author)

  8. Comparison of uteroplacental blood flow in normal and pre-eclamptic patients measurement with technetium-99m and a computer-linked gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Cho, S.H.; Moon, H.; Kim, D.S.; Cho, S.S.

    1985-05-01

    Uteroplacental blood flow studies in preeclampsia are of special interest since the vascular changes reported in this disease might constitute a structural basis for a reduction of blood flow. Evidence has also been given for a decreased uteroplacental blood flow in preeclampsia. Among the various methods to estimate the maternal placental blood flow, the one most frequently reported in the literature during the last years has been the time activity analysis of short lived radiotracer such as technetium-99m or indium-113m injected intravenously. Only few studies with the above mentioned technique comparing normal and preeclampsia cases have been undertaken. In clinical practice we frequently experience difficuly in finding the optimal time to get the delivery in preeclampsia patients. The aim of this study was first to measure uteroplacental blood flow in preeclamptic pregnancies using a computer-linked gamma camera method for the time-activity analysis of technetium-99m and second to discuss the possibility of clinical application of these measurements for determination of fetal well-being and the timing of the delivery in these patients. Uteroplacental blood flow was measured from 13 preeclamptic patients and 19 pregnancies without any complication after 35 completed weeks of gestation from Jan. 1983 to Sep. 1983 at Obstetrics department of Hanyang University Hospital. (Author).

  9. Mediastinal staging of lung cancer with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography and a dual-head coincidence gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, Michael; Reinartz, Patrick; Cremerius, Uwe; Buell, Udalrich [Department of Nuclear Medicine, University Hospital, Aachen University of Technology, Pauwelsstrasse 30, 52074 Aachen (Germany); Hochstenbag, Monique; Velde, Guul ten [Department of Pulmonology, University Hospital, 6229 HX Maastricht (Netherlands); Lamers, Rob [Department of Radiology, University Hospital, 6229 HX Maastricht (Netherlands)

    2003-04-01

    The aims of the present study were (a) to evaluate mediastinal staging in patients with lung cancer with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) using a coincidence gamma camera (hybrid PET) in comparison with dedicated positron emission tomography (PET) and computed tomography (CT), and (b) to assess the feasibility to determine standardized uptake values (SUV) with hybrid PET. Forty patients were included in the study. Hybrid PET was performed without and with attenuation correction. Data were rebinned with single-slice (SSRB) or Fourier rebinning (FORE). The SUVs of primary tumors were calculated with hybrid PET and compared with SUVs determined by dedicated PET. Diagnostic accuracy for hybrid with or without attenuation correction was 80 or 74% compared with 82% for dedicated PET, and 63% for CT. Attenuation-corrected hybrid PET revealed a higher specificity than CT (83 vs 52%; p<0.05). The SUVs of primary tumors were similar to those of hybrid PET and dedicated PET with a mean relative difference of 20.8{+-}16.4%. The FORE improved the agreement of SUVs with a mean relative difference of 13.8{+-}9.9 vs 36.0{+-}17.9% for SSRB (p<0.001). Hybrid PET with attenuation correction is more specific than CT for mediastinal staging in patients with lung cancer (p<0.05). It reveals similar results in comparison with dedicated PET. Calculation of SUVs with hybrid PET is feasible. (orig.)

  10. Proposal of balloon and satellite observations of MeV gammas using Electron Tracking Compton Camera for reaching a high sensitivity of 1 mCrab

    Science.gov (United States)

    Takada, Atsushi; Tanimori, Toru

    2016-04-01

    ETCC with a gas Time Projection Chamber (TPC) and pixel GSO scintillators, by measuring electron tracks precisely, provides both a strong background rejection by dE/dx of the track and well-defined 2-dimensional Point Spread Function (PDF) with better than several degrees by adding the arc direction of incident gammas (SPD: Scatter Plane Deviation) with the ARM (angular Resolution Measure) direction measured in standard Compton Camera (CC). In 2006 its background rejection was revealed by SMILE-I balloon experiment with 10cm-cubic ETCC using the dE/dx of tracks. In 2013, 30cm-cube-ETCC has been developed to catch gammas from Crab in next SMILE-II balloon with >5sigma detection for 4 hrs. Now its sensitivity has been improved to 10sigma by attaining the angular resolution of the track (SPD angle) to that determined by multiple scattering of the gas. Thus, we show the ability of ETCC to give a better significance by a factor of 10 than that of standard CCs having same detection area by electron tracking?and we have found that SPD is an essential to define the PSF of Compton imaging quantitatively. Such a well-defined PSF is, for the first time, able to provide reliable sensitivity in Compton imaging without assuming the use of optimization algorithm. These studies uncover the uncertainties of CCs from both points of view of the intense background and the difficulty of the definition of the PSF, and overcome the above problems. Based on this technology, SMILE-II with 3atm CF4 gas is expected to provide a 5times better sensitivity than COMPTEL in one month balloon, and 4modules of 50cm-cube ETCCs would exceed over 10^-12 erg/cm^2s^1 (1mCrab) in satellite. Here we summarize the performance of the ETCC and new astrophysics opened in near future by high sensitive observation of MeV gamma-rays.

  11. Testing and Performance Validation of a Sensitive Gamma Ray Camera Designed for Radiation Detection and Decommissioning Measurements in Nuclear Facilities-13044

    International Nuclear Information System (INIS)

    This paper describes the measurements, testing and performance validation of a sensitive gamma ray camera designed for radiation detection and quantification in the environment and decommissioning and hold-up measurements in nuclear facilities. The instrument, which is known as RadSearch, combines a sensitive and highly collimated LaBr3 scintillation detector with an optical (video) camera with controllable zoom and focus and a laser range finder in one detector head. The LaBr3 detector has a typical energy resolution of between 2.5% and 3% at the 662 keV energy of Cs-137 compared to that of NaI detectors with a resolution of typically 7% to 8% at the same energy. At this energy the tungsten shielding of the detector provides a shielding ratio of greater than 900:1 in the forward direction and 100:1 on the sides and from the rear. The detector head is mounted on a pan/tile mechanism with a range of motion of ±180 degrees (pan) and ±90 degrees (tilt) equivalent to 4 π steradians. The detector head with pan/tilt is normally mounted on a tripod or wheeled cart. It can also be mounted on vehicles or a mobile robot for access to high dose-rate areas and areas with high levels of contamination. Ethernet connects RadSearch to a ruggedized notebook computer from which it is operated and controlled. Power can be supplied either as 24-volts DC from a battery or as 50 volts DC supplied by a small mains (110 or 230 VAC) power supply unit that is co-located with the controlling notebook computer. In this latter case both power and Ethernet are supplied through a single cable that can be up to 80 metres in length. If a local battery supplies power, the unit can be controlled through wireless Ethernet. Both manual operation and automatic scanning of surfaces and objects is available through the software interface on the notebook computer. For each scan element making up a part of an overall scanned area, the unit measures a gamma ray spectrum. Multiple radionuclides may be

  12. Monitoring of the internal contamination of occupationally exposure personnel in services of nuclear medicine through the use of gamma cameras; Monitoreo de la contaminacion interna de personal ocupacionalmente expuesto en servicios de medicina nuclear mediante el uso de gamma camaras

    Energy Technology Data Exchange (ETDEWEB)

    Teran, M.; Paolino, A.; Savio, E. [Catedra de Radioquimica, Facultad de Quimica, Montevideo (Uruguay); Hermida, J.C. [Centro de Medicina Nuclear, Hospital de Clinicas, Facultad de Medicina, Montevideo (Uruguay); Dantas, B.M. [Laboratorio de Medidas In vivo, Instituto da Radioprotecao e Dosimetria, Rio de Janeiro (Brazil)

    2006-07-01

    The radionuclides incorporation can happen as a result of diverse activities; these include the work associated with the different stadiums of the nuclear fuel cycle, the use of radioactive sources in medicine, the scientific research, the agriculture and the industry. In Uruguay the main activities linked to the manipulation of open sources correspond those of Nuclear Medicine and from 2004, in the mark of the Project Arcal RLA 049 and being based on the Safety Guides of the IAEA it is implementing a program of internal monitoring in combined form the Nuclear Medicine Center of the Hospital of and the Radiochemistry class of the Faculty of Chemistry. In accordance with the publication of the ICRP 75 the emphasis of any monitoring program should be in the formal study of the doses in the workers to who are considered commendable of to receive in routine form an outstanding fraction of the dose limits or who work in areas where the exposures can be significant in the accident event. From April 2004, to the date has started a pilot plan by means of in that were established appropriate conditions of procedures and of safety in a reduced group of workers of the Nuclear Medicine area. In that period the first work limits, equipment adjustment, calibrations and registration systems were determined. The monitoring system implemented until the moment is carried out with a thyroid caption equipment. However these measurements are carried out in the university hospital embracing 40% of the involved workers of our country, with the purpose of reaching the covering of the biggest quantity of occupationally exposed personnel of private clinics. Also it was developed a new work proposal that allows to have an alternative measure method, in the event of not having the equipment habitually used. Among the conclusions of this work are that for the before exposed are considered the measure conditions but appropriate the following ones: Gamma Camera without collimator; Measurement

  13. Five year experience in the detection of recurrence of ovarian cancer with [F18]-FDG using an hybrid (CDET) gamma camera

    International Nuclear Information System (INIS)

    Objective: The aim of this study was to evaluate the role of [F18]-FDG-CDET in the detection of recurrence of ovarian cancer. Methods and patients: After a fast of 6 hours, the patient (pt) was injected I. V. with 150-250 MBq of [F18]-FDG and imaging (whole-body scan and at least a tomoscintigram) was started 60 min. later, using a PICKER-MARCONI dual-head or triple-head CDET gamma camera. Between July 1997 and July 2001, 81 pts were studied for suspected recurrence of ovarian carcinoma. To date, the results of 62 pts are evaluable with reference to histology after surgery or concordance with conventional imaging and long-term follow-up. From these, 27 pts were referred for occult recurrence (OR) defined by an increase in serum CA-125 levels with negative CI and the remaining 35 pts for equivocal aspect at conventional imaging (ECI). Results: [F18]-FDG-CDET was true positive in 47 cases, 27 confirmed by histology after surgery (13 OC, 14 ECI) and the remaining 20 confirmed by evolution and concordance with CI. [F18]-FDG-CDET was true negative in 13 cases (6 OC, 7 ECI) as confirmed by spontaneous normalisation of CA-125 levels and no events during a 20-month follow-up for 11 pts and histology after surgery for 2 pts. [F18]-FDG CDET was false negative (FN) in 2 pts with ECI, 1 pt with a lymph node metastasis of less than 10 mm in size and 1 pt with continuing increase of CA-125 levels and still negative conventional imaging during a 8 month follow-up. No false positive results was reported in our study. In summary, the overall sensitivity, specificity and accuracy on a per patient basis were respectively 47/49 (96%), 13/13 (100%) and 60/62 (97%). The positive and negative predictive values were respectively 47/47 (100%) and 13/15 ( 87%). Conclusion: The present series of 62 patients gives valuable experience in CDET as compared to the cumulated data by Gambhir et al (J Nucl Med May 2001) reporting on a total of 357 patients using dedicated PET. Our CDET results are

  14. Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification

    International Nuclear Information System (INIS)

    The purpose of this paper is to evaluate the ability of a prototype Compton camera (CC) to measure prompt gamma rays (PG) emitted during delivery of clinical proton pencil beams for prompt gamma imaging (PGI) as a means of providing in vivo verification of the delivered proton radiotherapy beams.A water phantom was irradiated with clinical 114 MeV and 150 MeV proton pencil beams. Up to 500 cGy of dose was delivered per irradiation using clinical beam currents. The prototype CC was placed 15 cm from the beam central axis and PGs from 0.2 MeV up to 6.5 MeV were measured during irradiation. From the measured data (2D) images of the PG emission were reconstructed. (1D) profiles were extracted from the PG images and compared to measured depth dose curves of the delivered proton pencil beams.The CC was able to measure PG emission during delivery of both 114 MeV and 150 MeV proton beams at clinical beam currents. 2D images of the PG emission were reconstructed for single 150 MeV proton pencil beams as well as for a 5   ×   5 cm mono-energetic layer of 114 MeV pencil beams. Shifts in the Bragg peak (BP) range were detectable on the 2D images. 1D profiles extracted from the PG images show that the distal falloff of the PG emission profile lined up well with the distal BP falloff. Shifts as small as 3 mm in the beam range could be detected from the 1D PG profiles with an accuracy of 1.5 mm or better. However, with the current CC prototype, a dose of 400 cGy was required to acquire adequate PG signal for 2D PG image reconstruction.It was possible to measure PG interactions with our prototype CC during delivery of proton pencil beams at clinical dose rates. Images of the PG emission could be reconstructed and shifts in the BP range were detectable. Therefore PGI with a CC for in vivo range verification during proton treatment delivery is feasible. However, improvements in the prototype CC detection efficiency and reconstruction algorithms are necessary to

  15. Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters.

    Science.gov (United States)

    Cambraia Lopes, Patricia; Clementel, Enrico; Crespo, Paulo; Henrotin, Sebastien; Huizenga, Jan; Janssens, Guillaume; Parodi, Katia; Prieels, Damien; Roellinghoff, Frauke; Smeets, Julien; Stichelbaut, Frederic; Schaart, Dennis R

    2015-08-01

    Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of neutron-induced background counts. In this work, we present an initial performance test of two knife-edge slit camera prototypes based on arrays of digital photon counters (DPCs). PG profiles emitted from a PMMA target upon irradiation with a 160 MeV proton pencil beams (about 6.5 × 10(9) protons delivered in total) were measured using detector modules equipped with four DPC arrays coupled to BGO or LYSO : Ce crystal matrices. The knife-edge slit collimator and detector module were placed at 15 cm and 30 cm from the beam axis, respectively, in all cases. The use of LYSO : Ce enabled time-of-flight (TOF) rejection of background events, by synchronizing the DPC readout electronics with the 106 MHz radiofrequency signal of the cyclotron. The signal-to-background (S/B) ratio of 1.6 obtained with a 1.5 ns TOF window and a 3 MeV-7 MeV energy window was about 3 times higher than that obtained with the same detector module without TOF discrimination and 2 times higher than the S/B ratio obtained with the BGO module. Even 1 mm shifts of the Bragg peak position translated into clear and consistent shifts of the PG profile if TOF discrimination was applied, for a total number of protons as low as about 6.5 × 10(8) and a detector surface of 6.6 cm × 6.6 cm. PMID:26216269

  16. F-18 Fluorodeoxyglucose Gamma Camera Positron Emission Tomography identifies those patients with non-small cell lung cancer who are suitable for surgery?

    International Nuclear Information System (INIS)

    This study assessed the accuracy of positron emission tomography using a modified gamma camera (GC-PET) versus that of CT for staging mediastinal involvement in non-small cell lung cancer. The potential impact of GCPET imaging on patient management was also estimated. 98 patients underwent CT imaging as part of routine management followed by GC-PET imaging as part of the study. GC-PET images were reported without knowledge of CT findings. For each patient, nodal resectability status derived from GC-PET and that from CT were compared with the histological stage established by mediastinoscopy or surgery. Potential impact on management was assessed by comparing actual management with that which would have resulted had the guidelines of the National Institute for Health and Clinical Excellence (NICE) for the use of dedicated PET been applied to GC-PET results. GC-PET differentiated resectable from unresectable lymph node involvement with an accuracy of 90%. Sensitivity and specificity were 79% and 93% respectively (ppv 73%, npv 95%). CT differentiated resectable from unresectable lymph node involvement with an accuracy of 72%, and a sensitivity and specificity of 64% and 74% respectively (ppv 39%, npv 89%). Management based on GC-PET results and NICE recommendations would have avoided 14 unnecessary mediastinoscopies and prevented three or possibly four abandoned resections. Two additional unnecessary mediastinoscopies would have resulted. This study suggests that GC-PET is more accurate than CT for nodal staging in NSCLC, and likely to impact favourably on management where dedicated PET is unavailable. (author)

  17. Corrections in dose assessment of 99mTc radiolabeled aerosol particles targeted to central human airways using planar gamma camera imaging.

    Science.gov (United States)

    Möller, Winfried; Felten, Kathrin; Meyer, Gabriele; Meyer, Peter; Seitz, Jürgen; Kreyling, Wolfgang G

    2009-03-01

    The dose of inhaled radiolabeled aerosols is usually assessed using gamma (GC) camera imaging. Because of the complex and inhomogeneous structure of the lung, consisting of soft tissue, the thoracic skeleton, blood vessels, and air spaces, proper attenuation correction coefficients are difficult to evaluate and the estimated doses bear high uncertainty. One hundred milliliters of aerosol boli composed of 100 nm diameter (99m)Tc radiolabeled carbon particles (Technegas) were targeted either to the airways (AW) or to 800-mL volumetric lung depth (alveoli, AL) in 11 healthy volunteers. In addition, 750-mL full breaths (FB) of aerosol were inhaled to a 800-mL lung depth. The deposited dose was measured by collecting aerosol from inhaled and exhaled air stream on filters, which were analyzed for radioactivity. Lung imaging was performed using a planar GC (posterior). Ratios of GC counts to deposited dose (GC/DD) were similar after FB and AL administration, but twofold lower after AW administration (p attenuation correction factors (ACF) were 2.5 +/- 0.5 (FB), 2.2 +/- 0.4 (AL), and 5.5 +/- 1.6 (AW, p mass index and GC/DD. Inhalation of radioaerosols used in medical diagnosis and therapy in combination with high central airway deposition results in an underestimation of the deposited dose based on planar GC imaging. The aerosol distribution index C/P may provide one suitable indicator for corrections, which should be confirmed in future studies by individual attenuation analysis based on radiotracer transmission measurements. PMID:18844481

  18. A liquid xenon radioisotope camera.

    Science.gov (United States)

    Zaklad, H.; Derenzo, S. E.; Muller, R. A.; Smadja, G.; Smits, R. G.; Alvarez, L. W.

    1972-01-01

    A new type of gamma-ray camera is discussed that makes use of electron avalanches in liquid xenon and is currently under development. It is shown that such a radioisotope camera promises many advantages over any other existing gamma-ray cameras. Spatial resolution better than 1 mm and counting rates higher than one million C/sec are possible. An energy resolution of 11% FWHM has recently been achieved with a collimated Hg-203 source using a parallel-plate ionization chamber containing a Frisch grid.

  19. Effects of Fe as a physical filter on spectra of Technitium- 99m, uniformity, system volume sensitivity and spatial resolution of Philip ADAC Forte dual-head gamma camera

    Science.gov (United States)

    Sohaimi, N.; Abdullah, N.; Shah, S. I.; Zakaria, A.

    2014-11-01

    Single photon emission computed tomography (SPECT) imaging inherits some limitations, i.e., due to scattered gamma photons which degrade spatial resolution causes poor image quality. This study attempts to reduce a fraction of scattered gamma photons before reaching gamma camera detector by using Fe sheet (0.35 mm and 0.40 mm) as a physical filter. Also investigate the effects on spectra of Tc-99m, spatial resolution, system volume sensitivity and uniformity. The thickness of Fe physical filter is selected on the basis of percentage attenuation calculations of different gamma ray energies by various thicknesses of material. Data were acquired using Philip ADAC forte dual-head gamma camera without and with physical filter with LEHR collimator installed. For spectra, uniformity and system volume sensitivity, a cylindrical source tank filled with water added with Tc-99m was scanned. Uniformity and system volume sensitivity images were reconstructed with FBP method by applying Butterworth filter of order 5, cut-off frequency 0.35 cycles/cm and Chang's attenuation correction method using 0.13 cm-1 linear attenuation coefficient. Spatial resolution study was done by scanning a line source (0.8 mm inner diameter) of Tc-99m at various source-to-collimator distances in air and in scattering medium without and with physical filter. A substantial reduction in count rate from Compton and photopeak regions of Tc-99m spectra with physical filter is recorded. Improvement in spatial resolution with physical filter up to 4 cm source-to-collimator distance is obtained. System volume sensitivity was reduced and no improvement in uniformity. These thicknesses of physical filter may be tested further by scanning different planar/SPECT phantoms in Tc-99m imaging.

  20. Effects of Fe as a physical filter on spectra of Technitium- 99m, uniformity, system volume sensitivity and spatial resolution of Philip ADAC Forte dual-head gamma camera

    International Nuclear Information System (INIS)

    Single photon emission computed tomography (SPECT) imaging inherits some limitations, i.e., due to scattered gamma photons which degrade spatial resolution causes poor image quality. This study attempts to reduce a fraction of scattered gamma photons before reaching gamma camera detector by using Fe sheet (0.35 mm and 0.40 mm) as a physical filter. Also investigate the effects on spectra of Tc-99m, spatial resolution, system volume sensitivity and uniformity. The thickness of Fe physical filter is selected on the basis of percentage attenuation calculations of different gamma ray energies by various thicknesses of material. Data were acquired using Philip ADAC forte dual-head gamma camera without and with physical filter with LEHR collimator installed. For spectra, uniformity and system volume sensitivity, a cylindrical source tank filled with water added with Tc-99m was scanned. Uniformity and system volume sensitivity images were reconstructed with FBP method by applying Butterworth filter of order 5, cut-off frequency 0.35 cycles/cm and Chang's attenuation correction method using 0.13 cm−1 linear attenuation coefficient. Spatial resolution study was done by scanning a line source (0.8 mm inner diameter) of Tc-99m at various source-to-collimator distances in air and in scattering medium without and with physical filter. A substantial reduction in count rate from Compton and photopeak regions of Tc-99m spectra with physical filter is recorded. Improvement in spatial resolution with physical filter up to 4 cm source-to-collimator distance is obtained. System volume sensitivity was reduced and no improvement in uniformity. These thicknesses of physical filter may be tested further by scanning different planar/SPECT phantoms in Tc-99m imaging

  1. Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters

    International Nuclear Information System (INIS)

    Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of neutron-induced background counts. In this work, we present an initial performance test of two knife-edge slit camera prototypes based on arrays of digital photon counters (DPCs). PG profiles emitted from a PMMA target upon irradiation with a 160 MeV proton pencil beams (about 6.5   ×   109 protons delivered in total) were measured using detector modules equipped with four DPC arrays coupled to BGO or LYSO : Ce crystal matrices. The knife-edge slit collimator and detector module were placed at 15 cm and 30 cm from the beam axis, respectively, in all cases. The use of LYSO : Ce enabled time-of-flight (TOF) rejection of background events, by synchronizing the DPC readout electronics with the 106 MHz radiofrequency signal of the cyclotron. The signal-to-background (S/B) ratio of 1.6 obtained with a 1.5 ns TOF window and a 3 MeV–7 MeV energy window was about 3 times higher than that obtained with the same detector module without TOF discrimination and 2 times higher than the S/B ratio obtained with the BGO module. Even 1 mm shifts of the Bragg peak position translated into clear and consistent shifts of the PG profile if TOF discrimination was applied, for a total number of protons as low as about 6.5   ×   108 and a detector surface of 6.6 cm  ×  6.6 cm. (paper)

  2. Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters

    Science.gov (United States)

    Cambraia Lopes, Patricia; Clementel, Enrico; Crespo, Paulo; Henrotin, Sebastien; Huizenga, Jan; Janssens, Guillaume; Parodi, Katia; Prieels, Damien; Roellinghoff, Frauke; Smeets, Julien; Stichelbaut, Frederic; Schaart, Dennis R.

    2015-08-01

    Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of neutron-induced background counts. In this work, we present an initial performance test of two knife-edge slit camera prototypes based on arrays of digital photon counters (DPCs). PG profiles emitted from a PMMA target upon irradiation with a 160 MeV proton pencil beams (about 6.5   ×   109 protons delivered in total) were measured using detector modules equipped with four DPC arrays coupled to BGO or LYSO : Ce crystal matrices. The knife-edge slit collimator and detector module were placed at 15 cm and 30 cm from the beam axis, respectively, in all cases. The use of LYSO : Ce enabled time-of-flight (TOF) rejection of background events, by synchronizing the DPC readout electronics with the 106 MHz radiofrequency signal of the cyclotron. The signal-to-background (S/B) ratio of 1.6 obtained with a 1.5 ns TOF window and a 3 MeV-7 MeV energy window was about 3 times higher than that obtained with the same detector module without TOF discrimination and 2 times higher than the S/B ratio obtained with the BGO module. Even 1 mm shifts of the Bragg peak position translated into clear and consistent shifts of the PG profile if TOF discrimination was applied, for a total number of protons as low as about 6.5   ×   108 and a detector surface of 6.6 cm  ×  6.6 cm.

  3. Camera calibration

    OpenAIRE

    Andrade-Cetto, J.

    2001-01-01

    This report is a tutorial on pattern based camera calibration for computer vision. The methods presented here allow for the computation of the intrinsic and extrinsic parameters of a camera. These methods are widely available in the literature, and they are only summarized here as an easy and comprehensive reference for researchers at the Institute and their collaborators.

  4. Proof of concept for low-dose molecular breast imaging with a dual-head CZT gamma camera. Part I. Evaluation in phantoms

    Energy Technology Data Exchange (ETDEWEB)

    Hruska, Carrie B.; Weinmann, Amanda L.; O' Connor, Michael K. [Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905 (United States)

    2012-06-15

    Purpose: Molecular breast imaging (MBI) is a nuclear medicine technology that uses dual-head cadmium zinc telluride (CZT) gamma cameras to image functional uptake of a radiotracer, Tc-99m sestamibi, in the breast. An important factor in adoption of MBI in the screening setting is reduction of the necessary administered dose of Tc-99m sestamibi from the typically used dose of 740 MBq to approximately 148 MBq, such that MBI's whole-body effective dose is comparable to that of screening mammography. Methods that increase MBI count sensitivity may allow a proportional reduction in the necessary administered dose. Our objective was to evaluate the impact of two count sensitivity improvement methods on image quality by evaluating count sensitivity, spatial resolution, and lesion contrast in phantom simulations. Methods: Two dual-head CZT-based MBI systems were studied: LumaGem and Discovery NM 750b. Two count sensitivity improvement methods were implemented: registered collimators optimized for dedicated breast imaging and widened energy acceptance window optimized for use with CZT. System sensitivity, spatial resolution, and tumor contrast-to-noise ratio (CNR) were measured comparing standard collimation and energy window setting [126-154 keV (+10%, -10%)] with optimal collimation and a wide energy window [110-154 keV (+10%, -21%)]. Results: Compared to the standard collimator designs and energy windows for these two systems, use of registered optimized collimation and wide energy window increased system sensitivity by a factor of 2.8-3.6. Spatial resolution decreased slightly for both systems with new collimation. At 3 cm from the collimator face, LumaGem's spatial resolution was 4.8 and 5.6 mm with standard and optimized collimation; Discovery NM 750b's spatial resolution was 4.4 and 4.6 mm with standard and optimized collimation, respectively. For both systems, at tumor depths of 1 and 3 cm, use of optimized collimation and wide energy window

  5. Monte-Carlo simulations of the background of the coded-mask camera for X- and Gamma-rays on-board the Chinese-French GRB mission SVOM

    CERN Document Server

    Godet, O; Barret, D; Mandrou, P; Cordier, B; Schanne, S; Remoue, N

    2009-01-01

    For several decades now, wide-field coded mask cameras have been used with success to localise Gamma-ray bursts (GRBs). In these instruments, the event count rate is dominated by the photon background due to their large field of view and large effective area. It is therefore essential to estimate the instrument background expected in orbit during the early phases of the instrument design in order to optimise the scientific performances of the mission. We present here a detailed study of the instrument background and sensitivity of the coded-mask camera for X- and Gamma-rays (CXG) to be used in the detection and localisation of high-redshift GRBs on-board the international GRB mission SVOM. To compute the background spectrum, a Monte-Carlo approach was used to simulate the primary and secondary interactions between particles from the main components of the space environment that SVOM will encounter along its Low Earth Orbit (LEO) (with an altitude of 600 km and an inclination of ~ 30 deg) and the body of the C...

  6. Routine 18F-2-deoxy-2-fluoro-D-glucose (18F-FDG) myocardial tomography using a normal large field of view gamma-camera

    International Nuclear Information System (INIS)

    There is a recent need to study glucose metabolism of the heart in ischemic, as well as in hibernating or stunned myocardium, and compare it with that in perfusion studies. In non-positron emission tomography centers, positron imaging is possible with a standard Anger-type camera if proper collimation and adequate shielding of the camera crystal can be achieved. For the study with fast-decaying isotopes, seven-pinhole tomography (7PHT), a limited-angle method designed for transaxial tomography of the left ventricle using a nonrotating camera, is well suited, because projections are acquired simultaneously. Individual adjustment (patient supine) of the camera's view axis (CAx) with the left ventricular axis (LVAx) gives excellent results: sensitivity for CHD 82%, specificity 72% in a prospective 201TI study (48 patients, x-ray coronarography as reference). Good alignment of CAx with LVAx is also achieved with the patient prone in LAO in a hammock above the camera surface. In this setting additional lead shielding of the camera is possible using a table reinforced with 5 cm of lead with a central hole for the 7PH-collimator, which has a special lead inlay. This allows utilization of the 511 KeV emitter 18F-FDG, which with a half-life of 109 minutes, can be transported a reasonable distance from the production site. System sensitivity and resolution for 18F was found comparable to 201Tl, 99mTc, and 123I using a phantom. First clinical examinations after 201Tl stress/redistribution studies showed increased 18F-FDG uptake in ischemic heart segments, as well as in hibernating nonperfused or stunned myocardium

  7. Monitoring the distribution of prompt gamma rays in boron neutron capture therapy using a multiple-scattering Compton camera: A Monte Carlo simulation study

    International Nuclear Information System (INIS)

    This study evaluated the use of Compton imaging technology to monitor prompt gamma rays emitted by 10B in boron neutron capture therapy (BNCT) applied to a computerized human phantom. The Monte Carlo method, including particle-tracking techniques, was used for simulation. The distribution of prompt gamma rays emitted by the phantom during irradiation with neutron beams is closely associated with the distribution of the boron in the phantom. Maximum likelihood expectation maximization (MLEM) method was applied to the information obtained from the detected prompt gamma rays to reconstruct the distribution of the tumor including the boron uptake regions (BURs). The reconstructed Compton images of the prompt gamma rays were combined with the cross-sectional images of the human phantom. Quantitative analysis of the intensity curves showed that all combined images matched the predetermined conditions of the simulation. The tumors including the BURs were distinguishable if they were more than 2 cm apart

  8. Monitoring the distribution of prompt gamma rays in boron neutron capture therapy using a multiple-scattering Compton camera: A Monte Carlo simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Taewoong; Lee, Hyounggun; Lee, Wonho, E-mail: wonhol@korea.ac.kr

    2015-10-21

    This study evaluated the use of Compton imaging technology to monitor prompt gamma rays emitted by {sup 10}B in boron neutron capture therapy (BNCT) applied to a computerized human phantom. The Monte Carlo method, including particle-tracking techniques, was used for simulation. The distribution of prompt gamma rays emitted by the phantom during irradiation with neutron beams is closely associated with the distribution of the boron in the phantom. Maximum likelihood expectation maximization (MLEM) method was applied to the information obtained from the detected prompt gamma rays to reconstruct the distribution of the tumor including the boron uptake regions (BURs). The reconstructed Compton images of the prompt gamma rays were combined with the cross-sectional images of the human phantom. Quantitative analysis of the intensity curves showed that all combined images matched the predetermined conditions of the simulation. The tumors including the BURs were distinguishable if they were more than 2 cm apart.

  9. An innovative SiPM-based camera for gamma-ray astronomy with the small size telescopes of the Cherenkov Telescope Array

    Science.gov (United States)

    Schioppa, E. J.; Heller, M.; Troyano Pujadas, I.; della Volpe, D.; Favre, Y.; Montaruli, T.; Zietara, K.; Kasperek, J.; Marszalek, A.; Rajda, P.

    2016-01-01

    A prototype camera for one of the Cherenkov Telescope Array (CTA) projects for the small size telescopes, the single mirror Small Size Telescope (SST-1M), has been designed and is under construction. The camera is a hexagonal matrix of 1296 large area (95 mm2) hexagonal silicon photomultipliers. The sensors are grouped into 108 modules of 12 pixels each, hosting a preamplifier board and a slow-control board. Among its various functions, this latter implements a compensation logic that adjusts the bias voltage of each sensor as a function of temperature. The fully digital readout and trigger system, DigiCam, is based on the latest generation of FPGAs, featuring a high number of high speed I/O interfaces, allowing high data transfer rates in an extremely compact design.

  10. An innovative SiPM-based camera for gamma-ray astronomy with the small size telescopes of the Cherenkov Telescope Array

    International Nuclear Information System (INIS)

    A prototype camera for one of the Cherenkov Telescope Array (CTA) projects for the small size telescopes, the single mirror Small Size Telescope (SST-1M), has been designed and is under construction. The camera is a hexagonal matrix of 1296 large area (95 mm2) hexagonal silicon photomultipliers. The sensors are grouped into 108 modules of 12 pixels each, hosting a preamplifier board and a slow-control board. Among its various functions, this latter implements a compensation logic that adjusts the bias voltage of each sensor as a function of temperature. The fully digital readout and trigger system, DigiCam, is based on the latest generation of FPGAs, featuring a high number of high speed I/O interfaces, allowing high data transfer rates in an extremely compact design

  11. Interstudy repeatability of left and right ventricular volume estimations by serial-gated tomographic radionuclide angiographies using a cadmium-zinc-telluride detector gamma camera

    DEFF Research Database (Denmark)

    Jensen, Maria M; Haase, Christine; Zerahn, Bo

    2015-01-01

    and ejection fraction estimations, using a cadmium-zinc-telluride (CZT) SPECT camera. MATERIALS AND METHODS: Forty-six patients were scanned twice, interrupted by repositioning. Each acquisition was analysed twice by two experienced technologists. Interstudy and interobserver variations were calculated......·3% (-6·90 to 5·20) and 7·0% (-13·9 to 11·1), respectively. For the right ventricle, the corresponding values were 11·9% (-9·40 to 10·8), 9·8% (-14·9 to 10·8) and 8·1% (-20·7 to 16·3). DISCUSSION: The CZT detector camera has excellent reproducibility with regard to interstudy variation when assessing LV...

  12. Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters

    NARCIS (Netherlands)

    Cambraia Lopes, P.; Clementel, E.; Crespo, P.; Henrotin, S.; Huizenga, J.; Janssens, G.; Parodi, K.; Prieels, D.; Roellinghoff, F.; Smeets, J.; Stichelbaut, F.; Schaart, D.R.

    2015-01-01

    Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in c

  13. CCD Color Camera Characterization for Image Measurements

    NARCIS (Netherlands)

    Withagen, P.J.; Groen, F.C.A.; Schutte, K.

    2007-01-01

    In this article, we will analyze a range of different types of cameras for its use in measurements. We verify a general model of a charged coupled device camera using experiments. This model includes gain and offset, additive and multiplicative noise, and gamma correction. It is shown that for sever

  14. Determination of the uptake rates of the bone for 99m-Tc-methylendiphosphonate by means of gamma-camera-scintiscanning and checking its diagnostic value for various skeleton diseases

    International Nuclear Information System (INIS)

    A model of uptake of labelled phosphate in the bones was used to derive a method of calculating the uptake rates for 99m-Tc-MDP. The precondition was the measurement of the change in radioactivity by means of a gamma camera within the lumbal part of the spine over 1 hour. The method was applied on 49 patients (7 with healthy bones, 6 cases of hyperparathyreoidism, 10 of osteoprosis, 9 cases of osteomalacia, 1 case of hypoparathyreoidism, 10 cases of ankylosing spondylitis, 6 tumours affecting the skeleton). Osteomalacia, ankylosing spondylitis, tumours, and, in 50% of the cases, hyperparathyreoidism could be differentiated from normal findings more significantly than using conventional scintiscanning. The author's expectations were met by the method. It is suitable for diagnosing metabolic osteopathis and controlling therapy in circumscribed bone foci. (orig.)

  15. CCD Camera

    Science.gov (United States)

    Roth, Roger R.

    1983-01-01

    A CCD camera capable of observing a moving object which has varying intensities of radiation eminating therefrom and which may move at varying speeds is shown wherein there is substantially no overlapping of successive images and wherein the exposure times and scan times may be varied independently of each other.

  16. Gamma camera based Positron Emission Tomography: a study of the viability on quantification; Tomografia por emissao de positrons com sistemas PET/SPECT: um estudo da viabilidade de quantifizacao

    Energy Technology Data Exchange (ETDEWEB)

    Pozzo, Lorena

    2005-07-01

    Positron Emission Tomography (PET) is a Nuclear Medicine imaging modality for diagnostic purposes. Pharmaceuticals labeled with positron emitters are used and images which represent the in vivo biochemical process within tissues can be obtained. The positron/electron annihilation photons are detected in coincidence and this information is used for object reconstruction. Presently, there are two types of systems available for this imaging modality: the dedicated systems and those based on gamma camera technology. In this work, we utilized PET/SPECT systems, which also allows for the traditional Nuclear Medicine studies based on single photon emitters. There are inherent difficulties which affect quantification of activity and other indices. They are related to the Poisson nature of radioactivity, to radiation interactions with patient body and detector, noise due to statistical nature of these interactions and to all the detection processes, as well as the patient acquisition protocols. Corrections are described in the literature and not all of them are implemented by the manufacturers: scatter, attenuation, random, decay, dead time, spatial resolution, and others related to the properties of each equipment. The goal of this work was to assess these methods adopted by two manufacturers, as well as the influence of some technical characteristics of PET/SPECT systems on the estimation of SUV. Data from a set of phantoms were collected in 3D mode by one camera and 2D, by the other. We concluded that quantification is viable in PET/SPECT systems, including the estimation of SUVs. This is only possible if, apart from the above mentioned corrections, the camera is well tuned and coefficients for sensitivity normalization and partial volume corrections are applied. We also verified that the shapes of the sources used for obtaining these factors play a role on the final results and should be delt with carefully in clinical quantification. Finally, the choice of the region

  17. Pre-chemotherapy values for left and right ventricular volumes and ejection fraction by gated tomographic radionuclide angiography using a cadmium-zinc-telluride detector gamma camera

    DEFF Research Database (Denmark)

    Haarmark, Christian; Haase, Christine; Jensen, Maria Maj;

    2016-01-01

    age and both left and right ventricular volumes in women (r = -0.4, P < .001) but only for right end systolic ventricular volume in men (r = -0.3, P = .001). CONCLUSION: A set of reference values for cardiac evaluation prior to chemotherapy in cancer patients without other known cardiopulmonary......BACKGROUND: Estimation of left ventricular ejection fraction (LVEF) using equilibrium radionuclide angiography is an established method for assessment of left ventricular function. The purpose of this study was to establish normative data on left and right ventricular volumes and ejection fraction......, using cadmium-zinc-telluride SPECT camera. METHODS AND RESULTS: From routine assessments of left ventricular function in 1172 patients, we included 463 subjects (194 men and 269 women) without diabetes, previous potentially cardiotoxic chemotherapy, known cardiovascular or pulmonary disease. The lower...

  18. CCD characterization for a range of color cameras

    NARCIS (Netherlands)

    Withagen, P.J.; Groen, F.C.A.; Schutte, K.

    2005-01-01

    CCD cameras are widely used for remote sensing and image processing applications. However, most cameras are produced to create nice images, not to do accurate measurements. Post processing operations such as gamma adjustment and automatic gain control are incorporated in the camera. When a (CCD) cam

  19. Invasive ductal carcinoma arising from dense accessory breast visualized with 99mTc-MIBI breast-specific γ imaging.

    Science.gov (United States)

    Yoon, Hai-Jeon; Sung, Sun Hee; Moon, Byung In; Kim, Bom Sahn

    2014-08-01

    Primary accessory breast cancer is extremely rare, and the diagnostic efficacy of Tc-MIBI breast-specific γ imaging (BSGI) has not been reported elsewhere. We present a case of primary carcinoma arising from dense accessory breast that was visualized with BSGI. A 43-year-old female patient with a palpable axillary mass underwent mammography, which showed dense parenchyma on both of the anatomic and accessory breasts with no abnormality. Subsequent BSGI showed no abnormal uptake in bilateral anatomic breasts, but focal abnormal uptake was noted in the accessory breast. Permanent pathologic evaluation confirmed invasive ductal carcinoma (not otherwise specified type) of the accessory breast. PMID:24445272

  20. Whole body retention of Se-75-homotaurocholic acid (SeBCAT) using a Gamma Camera: A new test in chronic diarrhea

    Energy Technology Data Exchange (ETDEWEB)

    Amaral, H.; Palma, R.; Pfau, J.; Coudeu, I.; Bauer, K.

    1985-05-01

    Bile acid malabsorption has been recognized as an important cause of chronic diarrhea. Se-75HCAT, a bile acid, is absorbed in the terminal ileum. Therefore, measurement of its body retention indicate ileal function not requiring fecal collections. The authors studied 8 normal volunteers presenting with chronic recurrent diarrhea for more than 2 years. Each received orally a 10 ..mu..Ci capsule of SeHCAT (Amersham Intl.) and 3 hours later anterior and posterior whole body activity was measured using a digital camera without collimator. Measurements were repeated daily for 7 days and expressed as % of retention. Three patients had normal retention (1 celiac disease, 1 inactive Crohn disease and 1 functional diarrhea), another was borderline (an immunodeficiency) and 4 patients presented abnormal bile acid absorption (2 had vagotomy, 1 Crohn disease and 1 idiopathic diarrhea). This last group was treated with cholestyramine showing improvement of the diarrhea, and relapse on drug withdrawal. These findings demonstrate that this technique can identify bile acid malabsorption as the cause of chronic diarrhea by external counting.

  1. Whole body retention of Se-75-homotaurocholic acid (SeBCAT) using a Gamma Camera: A new test in chronic diarrhea

    International Nuclear Information System (INIS)

    Bile acid malabsorption has been recognized as an important cause of chronic diarrhea. Se-75HCAT, a bile acid, is absorbed in the terminal ileum. Therefore, measurement of its body retention indicate ileal function not requiring fecal collections. The authors studied 8 normal volunteers presenting with chronic recurrent diarrhea for more than 2 years. Each received orally a 10 μCi capsule of SeHCAT (Amersham Intl.) and 3 hours later anterior and posterior whole body activity was measured using a digital camera without collimator. Measurements were repeated daily for 7 days and expressed as % of retention. Three patients had normal retention (1 celiac disease, 1 inactive Crohn disease and 1 functional diarrhea), another was borderline (an immunodeficiency) and 4 patients presented abnormal bile acid absorption (2 had vagotomy, 1 Crohn disease and 1 idiopathic diarrhea). This last group was treated with cholestyramine showing improvement of the diarrhea, and relapse on drug withdrawal. These findings demonstrate that this technique can identify bile acid malabsorption as the cause of chronic diarrhea by external counting

  2. Optimization of HiSens, a high sensitivity CdZnTe gamma-camera architecture dedicated to the clinical imaging applications

    International Nuclear Information System (INIS)

    To overcome the Anger camera spatial resolution-sensitivity trade-off, the HiSens architecture has been studied for several years. This architecture, based on pixelated CZT detectors, takes advantage of the accurate 3D localization of the interactions inside the detector. This work is dedicated to this architecture. First, a quantification methodology is introduced. This step allows preliminary simulation-based and experimental evaluation of the architecture in planar acquisition mode. A DQE (Detective Quantum Efficiency) calculation tool, aiming at optimizing the HiSens parameters in planar acquisition mode, is then proposed and used for two applications (cardiac imaging and scinti-mammography). lt shows that, considering a 5 cm source-collimator distance, the system sensitivity can be increased by 3 while maintaining or improving the spatial resolution thanks to the HiSens architecture. In this study, the collimator-to-detector distance parameter is made scalable. We show that its adjustment can advantageously increase the high frequency content of the reconstructed images. The effect of this parameter is experimentally validated in this work and has been besides patented. Finally, a SPECT DQE calculation tool is developed. This one, permitting to describe the system performances inside the field-of-view, is used, at the end of the work, to suggest a methodology allowing to determine the optimal collimation parameters for cardiac SPECT applications. (author)

  3. Short on camera geometry and camera calibration

    OpenAIRE

    Magnusson, Maria

    2010-01-01

    We will present the basic theory for the camera geometry. Our goal is camera calibration and the tools necessary for this. We start with homogeneous matrices that can be used to describe geometric transformations in a simple manner. Then we consider the pinhole camera model, the simplified camera model that we will show how to calibrate. A camera matrix describes the mapping from the 3D world to a camera image. The camera matrix can be determined through a number of corresponding points measu...

  4. Neutron Imaging Camera

    Science.gov (United States)

    Hunter, Stanley D.; DeNolfo, Georgia; Floyd, Sam; Krizmanic, John; Link, Jason; Son, Seunghee; Guardala, Noel; Skopec, Marlene; Stark, Robert

    2008-01-01

    We describe the Neutron Imaging Camera (NIC) being developed for DTRA applications by NASA/GSFC and NSWC/Carderock. The NIC is based on the Three-dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume time-projection chamber, provides accurate, approximately 0.4 mm resolution. 3-D tracking of charged particles. The incident direction of fast neutrons, E(sub N) > 0.5 MeV. arc reconstructed from the momenta and energies of the proton and triton fragments resulting from 3He(n,p)3H interactions in the 3-DTI volume. We present angular and energy resolution performance of the NIC derived from accelerator tests.

  5. Focussed radiographic camera

    International Nuclear Information System (INIS)

    A radiographic camera of the form employing a scintillator for producing optical photons in response to incident gamma and x-radiation is described. A collimator is positioned between a subject emitting such radiation and the scintillator for guiding the radiation to the scintillator and a detector of optical photons for signaling the positions of points of impingement of quanta of the incident radiation upon the scintillator to produce an image of the subject. A Fresnel focussing means is located alongside the scintillator for directing the optical photons to the detector. The Fresnel focussing means takes the form of a segmented mirror at the front surface of the scintillator and a Fresnel lens at the back surface of the scintillator

  6. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    International Nuclear Information System (INIS)

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm3 detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays’ performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects

  7. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras.

    Science.gov (United States)

    Bolotnikov, A E; Ackley, K; Camarda, G S; Cherches, C; Cui, Y; De Geronimo, G; Fried, J; Hodges, D; Hossain, A; Lee, W; Mahler, G; Maritato, M; Petryk, M; Roy, U; Salwen, C; Vernon, E; Yang, G; James, R B

    2015-07-01

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm(3) detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays' performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects. PMID:26233363

  8. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    Science.gov (United States)

    Bolotnikov, A. E.; Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hodges, D.; Hossain, A.; Lee, W.; Mahler, G.; Maritato, M.; Petryk, M.; Roy, U.; Salwen, C.; Vernon, E.; Yang, G.; James, R. B.

    2015-07-01

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm3 detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays' performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

  9. An array of virtual Frisch-grid CdZnTe detectors and a front-end application-specific integrated circuit for large-area position-sensitive gamma-ray cameras

    Energy Technology Data Exchange (ETDEWEB)

    Bolotnikov, A. E., E-mail: bolotnik@bnl.gov; Ackley, K.; Camarda, G. S.; Cherches, C.; Cui, Y.; De Geronimo, G.; Fried, J.; Hossain, A.; Mahler, G.; Maritato, M.; Roy, U.; Salwen, C.; Vernon, E.; Yang, G.; James, R. B. [Brookhaven National Laboratory, Upton, New York 11793 (United States); Hodges, D. [University of Texas at El Paso, El Paso, Texas 79968 (United States); Lee, W. [Korea University, Seoul 136-855 (Korea, Republic of); Petryk, M. [SUNY Binghamton, Vestal, New York 13902 (United States)

    2015-07-15

    We developed a robust and low-cost array of virtual Frisch-grid CdZnTe detectors coupled to a front-end readout application-specific integrated circuit (ASIC) for spectroscopy and imaging of gamma rays. The array operates as a self-reliant detector module. It is comprised of 36 close-packed 6 × 6 × 15 mm{sup 3} detectors grouped into 3 × 3 sub-arrays of 2 × 2 detectors with the common cathodes. The front-end analog ASIC accommodates up to 36 anode and 9 cathode inputs. Several detector modules can be integrated into a single- or multi-layer unit operating as a Compton or a coded-aperture camera. We present the results from testing two fully assembled modules and readout electronics. The further enhancement of the arrays’ performance and reduction of their cost are possible by using position-sensitive virtual Frisch-grid detectors, which allow for accurate corrections of the response of material non-uniformities caused by crystal defects.

  10. Measurement of cerebral blood flow the blood sampling method using {sup 99m}Tc-ECD. Simultaneous scintigram scanning of arterial blood samples and the brain with a gamma camera

    Energy Technology Data Exchange (ETDEWEB)

    Hachiya, Takenori; Inugami, Atsushi [Rehabilitation Center for Physically Disabled Persons and Medical Center for Mental Health-Akita, Kyowa (Japan); Iida, Hidehiro; Mizuta, Yoshihiko; Kawakami, Takeshi; Inoue, Minoru

    1999-01-01

    To measure regional cerebral blood flow (rCBF) by blood sampling using {sup 99m}Tc-ECD we devised a method of measuring the radioactive concentration in arterial blood sample with a gamma camera. In this method the head and a blood sample are placed within the same visual field to record the SPECT data of both specimens simultaneously. The results of an evaluation of the counting rate performance, applying the 30 hours decaying method using {sup 99m}Tc solution showed that this method is not comparable to the well-type scintillation counter and in clinical cases the active concentration in arterial blood sample remained well within the dynamic range. In addition, examination of the influence of scattered radiation from the brain by the dilution method showed that it was negligible at a distance of more than 7.5 cm between the brain and the arterial blood sample. In the present study we placed a head-shaped phantom next to the sample. The results of the examinations suggested that this method is suitable for clinical application, and because it does not require a well-type scintillation counter, it is expected to find wide application. (author)

  11. Proactive PTZ Camera Control

    Science.gov (United States)

    Qureshi, Faisal Z.; Terzopoulos, Demetri

    We present a visual sensor network—comprising wide field-of-view (FOV) passive cameras and pan/tilt/zoom (PTZ) active cameras—capable of automatically capturing closeup video of selected pedestrians in a designated area. The passive cameras can track multiple pedestrians simultaneously and any PTZ camera can observe a single pedestrian at a time. We propose a strategy for proactive PTZ camera control where cameras plan ahead to select optimal camera assignment and handoff with respect to predefined observational goals. The passive cameras supply tracking information that is used to control the PTZ cameras.

  12. Gamma camera determination of thyroid mass

    International Nuclear Information System (INIS)

    A method is suggested for imaging of the thyroid area as a zone of interest and determination of the number of elements of the matrix (the pixels) upon which the image is built. The value of each pixel in square centimeters for different martices and image densities is obtained by preliminary calibration and placing at an exactly determined distance (20 cm apart) two syringes with 1,75 MBq 99mTc-pertechnetate activity each. Knowing the distance between the two radioactive sources, one readily estimates the calibration coefficient. The surface value, obtained directly in the zone of interest, multiplied by the calibration coefficient, is expressed in square centimeters. Once the surface of the thyroid has been determined, its mass is readily estimated. Results are presented in 9 tables allowing to define the thyroid mass at different matrices and magnifications by the number of pixels

  13. A compact gamma camera for biological imaging

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, E L; Cella, J; Majewski, S; Popov, V; Qian, Jianguo; Saha, M S; Smith, M F; Weisenberger, A G; Welsh, R E

    2006-02-01

    A compact detector, sized particularly for imaging a mouse, is described. The active area of the detector is approximately 46 mm; spl times/ 96 mm. Two flat-panel Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs) are coupled to a pixellated NaI(Tl) scintillator which views the animal through a copper-beryllium (CuBe) parallel-hole collimator specially designed for {sup 125}I. Although the PSPMTs have insensitive areas at their edges and there is a physical gap, corrections for scintillation light collection at the junction between the two tubes results in a uniform response across the entire rectangular area of the detector. The system described has been developed to optimize both sensitivity and resolution for in-vivo imaging of small animals injected with iodinated compounds. We demonstrate an in-vivo application of this detector, particularly to SPECT, by imaging mice injected with approximately 10-15; spl mu/Ci of {sup 125}I.

  14. Calibration of a Stereo Radiation Detection Camera Using Planar Homography

    OpenAIRE

    Seung-Hae Baek; Pathum Rathnayaka; Soon-Yong Park

    2016-01-01

    This paper proposes a calibration technique of a stereo gamma detection camera. Calibration of the internal and external parameters of a stereo vision camera is a well-known research problem in the computer vision society. However, few or no stereo calibration has been investigated in the radiation measurement research. Since no visual information can be obtained from a stereo radiation camera, it is impossible to use a general stereo calibration algorithm directly. In this paper, we develop ...

  15. Central Acceptance Testing for Camera Technologies for CTA

    OpenAIRE

    Bonardi, A.; T. Buanes; Chadwick, P.; Dazzi, F.; A. Förster(CERN, Geneva, Switzerland); Hörandel, J. R.; Punch, M.; Consortium, R. M. Wagner for the CTA

    2015-01-01

    The Cherenkov Telescope Array (CTA) is an international initiative to build the next generation ground based very-high energy gamma-ray observatory. It will consist of telescopes of three different sizes, employing several different technologies for the cameras that detect the Cherenkov light from the observed air showers. In order to ensure the compliance of each camera technology with CTA requirements, CTA will perform central acceptance testing of each camera technology. To assist with thi...

  16. Developments in mercuric iodide gamma ray imaging

    International Nuclear Information System (INIS)

    A mercuric iodide (HgI2) gamma ray imaging array and camera system previously described have been characterized for spatial and energy resolution. Based on these data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criteria for the new camera will be presented. (orig.)

  17. Developments in mercuric iodide gamma ray imaging

    Science.gov (United States)

    Patt, B. E.; Beyerle, A. G.; Dolin, R. C.; Ortale, C.

    1989-11-01

    A mercuric iodide (HgI2) gamma ray imaging array and camera system previously described have been characterized for spatial and energy resolution. Based on these data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criteria for the new camera will be presented.

  18. Developments in mercuric iodide gamma ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Patt, B.E.; Beyerle, A.G.; Dolin, R.C.; Ortale, C.

    1987-01-01

    A mercuric iodide gamma-ray imaging array and camera system previously described has been characterized for spatial and energy resolution. Based on this data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criterion for the new camera will be presented. 2 refs., 7 figs.

  19. Developments in mercuric iodide gamma ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Patt, B.E.; Beyerle, A.G.; Dolin, R.C.; Ortale, C. (EG and G Energy Measurements, Inc., Goleta, CA (USA). Santa Barbara Operations)

    1989-11-01

    A mercuric iodide (HgI{sub 2}) gamma ray imaging array and camera system previously described have been characterized for spatial and energy resolution. Based on these data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criteria for the new camera will be presented. (orig.).

  20. Calibration of the cameras of the H.E.S.S. {gamma}-ray astronomy experiment and observations of the Galactic Centre above 100 GeV; Etalonnage des cameras de l'experience d'astronomie {gamma} H.E.S.S. et observations du centre galactique au-dela de 100 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Rolland, L

    2005-05-15

    The H.E.S.S. experiment (High Energy Stereoscopic System) consists of four imaging atmospheric Cherenkov telescopes to study the southern astrophysical sources above 100 GeV. This thesis presents the detector as well as the analysis chain. The calibration methods are described in details and the systematic errors on the image amplitude are derived. Then, an analysis based on a semi-analytical model of the electromagnetic shower development in the atmosphere is presented. Tools to reconstruct the energy spectrum and the morphology of the very high energy {gamma}-ray sources are presented and applied to the Crab Nebula. Systematic errors associated to the spectrum analysis are estimated. All these techniques were applied to study the Galactic Centre emission above 100 GeV. The nature of the source detected in 2003 and 2004 observations is still unknown and its spectrum, variability and morphology are studied. Various candidates are proposed, among them the supermassive black hole Sgr A* located at the dynamical centre of the Milky Way, the supernova remnant Sgr A Est or interactions of accelerated particles with the dense medium of this region. In this thesis, the signal was interpreted in terms of dark matter annihilation (neutralinos or Kaluza-Klein bosons) in a dense halo located at the Galactic Centre. This analysis showed that, in the framework of these models, dark matter annihilation alone can not explain the H.E.S.S. signal. The main component would thus come from astrophysical sources. (author)

  1. Dual-head gamma camera 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography in oncological patients: effects of non-uniform attenuation correction on lesion detection

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M.; Kaiser, H.J.; Cremerius, U.; Reinartz, P.; Schreckenberger, M.; Sabri, O.; Buell, U. [Department of Nuclear Medicine, University Hospital, Aachen University of Technology (Germany)

    1999-08-01

    The purpose of this study was to evaluate a dual head coincidence gamma camera (DH-PET) equipped with single-photon transmission for 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) imaging in oncological patients. Forty-five patients with known or suspected malignancies, scheduled for a positron emission tomography (PET) scan, were first studied with a dedicated ring PET and subsequently with DH-PET. All patients underwent measured attenuation correction using germanium-68 rod sources for ring PET and caesium-137 sources for DH-PET. Ring PET emission scan was started 64{+-}17 min after intravenous administration of 235{+-}42 MBq FDG. DH-PET emission followed 160{+-}32 min after i.v. FDG. Attenuation-corrected and non-attenuation-corrected images were reconstructed for ring PET and DH-PET. The image sets were evaluated independently by three observers blinded to clinical data and to results of conventional imaging. Attenuation-corrected ring PET as the standard of reference depicted 118 lesions, non-attenuation-corrected ring PET 113 (96%) lesions, and attenuation-corrected DH-PET and non-attenuation-corrected DH-PET, 101 (86%) and 84 (71%) lesions, respectively (P<0.05). The lesion detection rate of attenuation-corrected and non-attenuation-corrected DH-PET was almost similar for lesions >20 mm, whereas attenuation correction increased the detection rate from 60% to 80% for lesions {<=}20 mm (P<0.01). A patient-based analysis revealed concordant results relative to attenuation-corrected ring PET for non-attenuation-corrected ring PET, attenuation-corrected DH-PET and non-attenuation-corrected DH-PET in 42 (93%), 36 (80%) and 31 (69%) patients, respectively. Differences might have influenced patient management in two (4%), six (13%) and ten (22%) patients, respectively. In conclusion, measured attenuation correction markedly improves the lesion detection capability of DH-PET. With measured attenuation correction the diagnostic performance of DH-PET is closer to that

  2. PET with a dual-head coincidence gamma camera in head and neck cancer: A comparison with computed tomography and dedicated PET; Stellenwert der PET mit Koinzidenz-Gammakameras bei Kopf-Hals-Tumoren: Vergleich mit Computertomographie und dedizierter PET

    Energy Technology Data Exchange (ETDEWEB)

    Zimny, M. [Technische Hochschule Aachen (Germany). Klinik fuer Nuklearmedizin

    2001-11-01

    Positron emission tomography with {sup 18}F-fluoro-deoxyglucose (FDG PET) is a promising imaging tool for detecting and staging of primary or recurrent head and neck cancer. The aim of this study was to evaluate a dual-head gamma camera modified for coincidence detection (KGK-PET) in comparison to computed tomography (CT) and dedicated PET (dPET). 50 patients with known or suspected primary or recurrent head and neck cancer were enrolled. 32 patients underwent KGK-PET and dPET using a one-day protocol. The sensitivity for the detection of primary/ recurrent head and neck cancer for KGK-PET and CT was 80% and 54%, respectively, specificity was 73% and 82%, respectively. The sensitivity and specificity for the detection of lymph node metastases based on neck sides with KGK-PET was 71% (CT: 65%) and 88% (CT: 89%) respectively. In comparison to dPET, KGK-PET revealed concordant results in 32/32 patients with respect to primary tumor/recurrent disease and in 55/60 evaluated neck sides. All involved neck sides that were missed by KGK-PET were also negative with dPET. These results indicate that in patients with head and neck cancer KGK-PET reveals information, that are similar to dPET and complementary to CT. (orig.) [German] Die Positronenemissionstomographie mit {sup 18}F-Fluor-Deoxyglukose (FDG-PET) ist ein viel versprechendes Verfahren zur Detektion und zum Staging von primaeren und rezidivierenden Malignomen der Kopf-Hals-Region. Ziel der Studie war die Evaluation einer koinzidenzfaehigen Doppelkopf-Gammakamera (KGK-PET) im Vergleich zur Computertomographie (CT) und dedizierten Ring-PET (dPET). Untersucht wurden 50 Patienten mit Kopf-Hals-Tumoren. Vergleichsuntersuchungen mit dPET erfolgten bei 32 Patienten. Die Sensitivitaet von KGK-PET zur Erkennung von Primaertumoren/Rezidiven betrug 80% bei einer Spezifitaet von 73%. Fuer CT berechnete sich eine Sensitivitaet von 54% und eine Spezifitaet von 82%. Bezueglich einer zervikalen Lymphknotenmetastasierung errechnete

  3. Vacuum Camera Cooler

    Science.gov (United States)

    Laugen, Geoffrey A.

    2011-01-01

    Acquiring cheap, moving video was impossible in a vacuum environment, due to camera overheating. This overheating is brought on by the lack of cooling media in vacuum. A water-jacketed camera cooler enclosure machined and assembled from copper plate and tube has been developed. The camera cooler (see figure) is cup-shaped and cooled by circulating water or nitrogen gas through copper tubing. The camera, a store-bought "spy type," is not designed to work in a vacuum. With some modifications the unit can be thermally connected when mounted in the cup portion of the camera cooler. The thermal conductivity is provided by copper tape between parts of the camera and the cooled enclosure. During initial testing of the demonstration unit, the camera cooler kept the CPU (central processing unit) of this video camera at operating temperature. This development allowed video recording of an in-progress test, within a vacuum environment.

  4. The GCT camera for the Cherenkov Telescope Array

    CERN Document Server

    Brown, Anthony M; Allan, D; Amans, J P; Armstrong, T P; Balzer, A; Berge, D; Boisson, C; Bousquet, J -J; Bryan, M; Buchholtz, G; Chadwick, P M; Costantini, H; Cotter, G; Daniel, M K; De Franco, A; De Frondat, F; Dournaux, J -L; Dumas, D; Fasola, G; Funk, S; Gironnet, J; Graham, J A; Greenshaw, T; Hervet, O; Hidaka, N; Hinton, J A; Huet, J -M; Jegouzo, I; Jogler, T; Kraus, M; Lapington, J S; Laporte, P; Lefaucheur, J; Markoff, S; Melse, T; Mohrmann, L; Molyneux, P; Nolan, S J; Okumura, A; Osborne, J P; Parsons, R D; Rosen, S; Ross, D; Rowell, G; Sato, Y; Sayede, F; Schmoll, J; Schoorlemmer, H; Servillat, M; Sol, H; Stamatescu, V; Stephan, M; Stuik, R; Sykes, J; Tajima, H; Thornhill, J; Tibaldo, L; Trichard, C; Vink, J; Watson, J J; White, R; Yamane, N; Zech, A; Zink, A; Zorn, J

    2016-01-01

    The Gamma-ray Cherenkov Telescope (GCT) is proposed for the Small-Sized Telescope component of the Cherenkov Telescope Array (CTA). GCT's dual-mirror Schwarzschild-Couder (SC) optical system allows the use of a compact camera with small form-factor photosensors. The GCT camera is ~0.4 m in diameter and has 2048 pixels; each pixel has a ~0.2 degree angular size, resulting in a wide field-of-view. The design of the GCT camera is high performance at low cost, with the camera housing 32 front-end electronics modules providing full waveform information for all of the camera's 2048 pixels. The first GCT camera prototype, CHEC-M, was commissioned during 2015, culminating in the first Cherenkov images recorded by a SC telescope and the first light of a CTA prototype. In this contribution we give a detailed description of the GCT camera and present preliminary results from CHEC-M's commissioning.

  5. Harpicon camera for HDTV

    Science.gov (United States)

    Tanada, Jun

    1992-08-01

    Ikegami has been involved in broadcast equipment ever since it was established as a company. In conjunction with NHK it has brought forth countless television cameras, from black-and-white cameras to color cameras, HDTV cameras, and special-purpose cameras. In the early days of HDTV (high-definition television, also known as "High Vision") cameras the specifications were different from those for the cameras of the present-day system, and cameras using all kinds of components, having different arrangements of components, and having different appearances were developed into products, with time spent on experimentation, design, fabrication, adjustment, and inspection. But recently the knowhow built up thus far in components, , printed circuit boards, and wiring methods has been incorporated in camera fabrication, making it possible to make HDTV cameras by metbods similar to the present system. In addition, more-efficient production, lower costs, and better after-sales service are being achieved by using the same circuits, components, mechanism parts, and software for both HDTV cameras and cameras that operate by the present system.

  6. Digital Pinhole Camera

    Science.gov (United States)

    Lancor, Rachael; Lancor, Brian

    2014-01-01

    In this article we describe how the classic pinhole camera demonstration can be adapted for use with digital cameras. Students can easily explore the effects of the size of the pinhole and its distance from the sensor on exposure time, magnification, and image quality. Instructions for constructing a digital pinhole camera and our method for…

  7. Adapting Virtual Camera Behaviour

    DEFF Research Database (Denmark)

    Burelli, Paolo

    2013-01-01

    In a three-dimensional virtual environment aspects such as narrative and interaction completely depend on the camera since the camera defines the player’s point of view. Most research works in automatic camera control aim to take the control of this aspect from the player to automatically gen......- erate cinematographic game experiences reducing, however, the player’s feeling of agency. We propose a methodology to integrate the player in the camera control loop that allows to design and generate personalised cinematographic expe- riences. Furthermore, we present an evaluation of the afore......- mentioned methodology showing that the generated camera movements are positively perceived by novice asnd intermediate players....

  8. Automated Camera Calibration

    Science.gov (United States)

    Chen, Siqi; Cheng, Yang; Willson, Reg

    2006-01-01

    Automated Camera Calibration (ACAL) is a computer program that automates the generation of calibration data for camera models used in machine vision systems. Machine vision camera models describe the mapping between points in three-dimensional (3D) space in front of the camera and the corresponding points in two-dimensional (2D) space in the camera s image. Calibrating a camera model requires a set of calibration data containing known 3D-to-2D point correspondences for the given camera system. Generating calibration data typically involves taking images of a calibration target where the 3D locations of the target s fiducial marks are known, and then measuring the 2D locations of the fiducial marks in the images. ACAL automates the analysis of calibration target images and greatly speeds the overall calibration process.

  9. Gamma teletopography

    International Nuclear Information System (INIS)

    The mapping of gamma sources radiation emission in a nuclear plant is an important safety point. A remote gamma ray mapping process was developed in SPS/CEA/SACLAY. It uses the ''pinhole camera'' principle, precursor of photography. It mainly consists of a radiation proof box, with a small orifice, containing sensitive emulsions at the opposite. A first conventional photographic type emulsion photographs the area. A second photographic emulsion shows up the gamma radiations. The superim position of the two shots gives immediate informations of the precise location of each source of radiation in the observed area. To make easier the presentation and to improve the accuracy of the results for radiation levels mapping, the obtained films are digitally processed. The processing assigns a colours scale to the various levels of observed radiations. Taking account physical data and standard parameters, it gets possible to estimate the dose rate. The device is portable. Its compactness and fully independent nature make it suitable for use anywhere. It can be adapted to a remote automatic handling system, robot... so as to avoid all operator exposure when the local dose rate is too high

  10. Calibration of a Stereo Radiation Detection Camera Using Planar Homography

    Directory of Open Access Journals (Sweden)

    Seung-Hae Baek

    2016-01-01

    Full Text Available This paper proposes a calibration technique of a stereo gamma detection camera. Calibration of the internal and external parameters of a stereo vision camera is a well-known research problem in the computer vision society. However, few or no stereo calibration has been investigated in the radiation measurement research. Since no visual information can be obtained from a stereo radiation camera, it is impossible to use a general stereo calibration algorithm directly. In this paper, we develop a hybrid-type stereo system which is equipped with both radiation and vision cameras. To calibrate the stereo radiation cameras, stereo images of a calibration pattern captured from the vision cameras are transformed in the view of the radiation cameras. The homography transformation is calibrated based on the geometric relationship between visual and radiation camera coordinates. The accuracy of the stereo parameters of the radiation camera is analyzed by distance measurements to both visual light and gamma sources. The experimental results show that the measurement error is about 3%.

  11. GRACE star camera noise

    Science.gov (United States)

    Harvey, Nate

    2016-08-01

    Extending results from previous work by Bandikova et al. (2012) and Inacio et al. (2015), this paper analyzes Gravity Recovery and Climate Experiment (GRACE) star camera attitude measurement noise by processing inter-camera quaternions from 2003 to 2015. We describe a correction to star camera data, which will eliminate a several-arcsec twice-per-rev error with daily modulation, currently visible in the auto-covariance function of the inter-camera quaternion, from future GRACE Level-1B product releases. We also present evidence supporting the argument that thermal conditions/settings affect long-term inter-camera attitude biases by at least tens-of-arcsecs, and that several-to-tens-of-arcsecs per-rev star camera errors depend largely on field-of-view.

  12. Analytical multicollimator camera calibration

    Science.gov (United States)

    Tayman, W.P.

    1978-01-01

    Calibration with the U.S. Geological survey multicollimator determines the calibrated focal length, the point of symmetry, the radial distortion referred to the point of symmetry, and the asymmetric characteristiecs of the camera lens. For this project, two cameras were calibrated, a Zeiss RMK A 15/23 and a Wild RC 8. Four test exposures were made with each camera. Results are tabulated for each exposure and averaged for each set. Copies of the standard USGS calibration reports are included. ?? 1978.

  13. Solid state video cameras

    CERN Document Server

    Cristol, Y

    2013-01-01

    Solid State Video Cameras reviews the state of the art in the field of solid-state television cameras as compiled from patent literature. Organized into 10 chapters, the book begins with the basic array types of solid-state imagers and appropriate read-out circuits and methods. Documents relating to improvement of picture quality, such as spurious signal suppression, uniformity correction, or resolution enhancement, are also cited. The last part considerssolid-state color cameras.

  14. Polarization encoded color camera.

    Science.gov (United States)

    Schonbrun, Ethan; Möller, Guðfríður; Di Caprio, Giuseppe

    2014-03-15

    Digital cameras would be colorblind if they did not have pixelated color filters integrated into their image sensors. Integration of conventional fixed filters, however, comes at the expense of an inability to modify the camera's spectral properties. Instead, we demonstrate a micropolarizer-based camera that can reconfigure its spectral response. Color is encoded into a linear polarization state by a chiral dispersive element and then read out in a single exposure. The polarization encoded color camera is capable of capturing three-color images at wavelengths spanning the visible to the near infrared. PMID:24690806

  15. LSST Camera Optics Design

    Energy Technology Data Exchange (ETDEWEB)

    Riot, V J; Olivier, S; Bauman, B; Pratuch, S; Seppala, L; Gilmore, D; Ku, J; Nordby, M; Foss, M; Antilogus, P; Morgado, N

    2012-05-24

    The Large Synoptic Survey Telescope (LSST) uses a novel, three-mirror, telescope design feeding a camera system that includes a set of broad-band filters and three refractive corrector lenses to produce a flat field at the focal plane with a wide field of view. Optical design of the camera lenses and filters is integrated in with the optical design of telescope mirrors to optimize performance. We discuss the rationale for the LSST camera optics design, describe the methodology for fabricating, coating, mounting and testing the lenses and filters, and present the results of detailed analyses demonstrating that the camera optics will meet their performance goals.

  16. Collimated trans-axial tomographic scintillation camera

    International Nuclear Information System (INIS)

    The objects of this invention are first to reduce the time required to obtain statistically significant data in trans-axial tomographic radioisotope scanning using a scintillation camera. Secondly, to provide a scintillation camera system to increase the rate of acceptance of radioactive events to contribute to the positional information obtainable from a known radiation source without sacrificing spatial resolution. Thirdly to reduce the scanning time without loss of image clarity. The system described comprises a scintillation camera detector, means for moving this in orbit about a cranial-caudal axis relative to a patient and a collimator having septa defining apertures such that gamma rays perpendicular to the axis are admitted with high spatial resolution, parallel to the axis with low resolution. The septa may be made of strips of lead. Detailed descriptions are given. (U.K.)

  17. Explosive Transient Camera (ETC) Program

    Science.gov (United States)

    Ricker, George

    1991-01-01

    Since the inception of the ETC program, a wide range of new technologies was developed to support this astronomical instrument. The prototype unit was installed at ETC Site 1. The first partially automated observations were made and some major renovations were later added to the ETC hardware. The ETC was outfitted with new thermoelectrically-cooled CCD cameras and a sophisticated vacuum manifold, which, together, made the ETC a much more reliable unit than the prototype. The ETC instrumentation and building were placed under full computer control, allowing the ETC to operate as an automated, autonomous instrument with virtually no human intervention necessary. The first fully-automated operation of the ETC was performed, during which the ETC monitored the error region of the repeating soft gamma-ray burster SGR 1806-21.

  18. Camera Operator and Videographer

    Science.gov (United States)

    Moore, Pam

    2007-01-01

    Television, video, and motion picture camera operators produce images that tell a story, inform or entertain an audience, or record an event. They use various cameras to shoot a wide range of material, including television series, news and sporting events, music videos, motion pictures, documentaries, and training sessions. Those who film or…

  19. The Circular Camera Movement

    DEFF Research Database (Denmark)

    Hansen, Lennard Højbjerg

    2014-01-01

    It has been an accepted precept in film theory that specific stylistic features do not express specific content. Nevertheless, it is possible to find many examples in the history of film in which stylistic features do express specific content: for instance, the circular camera movement is used...... circular camera movement. Keywords: embodied perception, embodied style, explicit narration, interpretation, style pattern, television style...

  20. CCD Luminescence Camera

    Science.gov (United States)

    Janesick, James R.; Elliott, Tom

    1987-01-01

    New diagnostic tool used to understand performance and failures of microelectronic devices. Microscope integrated to low-noise charge-coupled-device (CCD) camera to produce new instrument for analyzing performance and failures of microelectronics devices that emit infrared light during operation. CCD camera also used to indentify very clearly parts that have failed where luminescence typically found.

  1. Thermal Cameras and Applications

    DEFF Research Database (Denmark)

    Gade, Rikke; Moeslund, Thomas B.

    2014-01-01

    Thermal cameras are passive sensors that capture the infrared radiation emitted by all objects with a temperature above absolute zero. This type of camera was originally developed as a surveillance and night vision tool for the military, but recently the price has dropped, significantly opening up...... a broader field of applications. Deploying this type of sensor in vision systems eliminates the illumination problems of normal greyscale and RGB cameras. This survey provides an overview of the current applications of thermal cameras. Applications include animals, agriculture, buildings, gas...... detection, industrial, and military applications, as well as detection, tracking, and recognition of humans. Moreover, this survey describes the nature of thermal radiation and the technology of thermal cameras....

  2. A modular scintillation camera for use in nuclear medicine

    International Nuclear Information System (INIS)

    A ''modular'' scintillation camera is discussed as an alternative to using Anger cameras for gamma-ray imaging in nuclear medicine. Each module is an independent gamma camera and consists of a scintillation crystal, light pipe and mask plane, PMT's, and processing electronics. Groups of modules efficiently image radionuclide distributions by effectively utilizing crystal area. Performance of each module is maximized by using Monte-Carlo computer simulations to determine the optical design of the camera, optimizing the signal processing of the PMT signals using maximum-likelihood (ML) estimators, and incorporating digital lookup tables. Each event is completely processed in 2 μsec, and FWHM of the PSF over the crystal area is expected to be 3 mm. Both one-dimensional and two-dimensional prototypes are tested for spatial and energy resolution

  3. Structured light camera calibration

    Science.gov (United States)

    Garbat, P.; Skarbek, W.; Tomaszewski, M.

    2013-03-01

    Structured light camera which is being designed with the joined effort of Institute of Radioelectronics and Institute of Optoelectronics (both being large units of the Warsaw University of Technology within the Faculty of Electronics and Information Technology) combines various hardware and software contemporary technologies. In hardware it is integration of a high speed stripe projector and a stripe camera together with a standard high definition video camera. In software it is supported by sophisticated calibration techniques which enable development of advanced application such as real time 3D viewer of moving objects with the free viewpoint or 3D modeller for still objects.

  4. Camera as Cultural Critique

    DEFF Research Database (Denmark)

    Suhr, Christian

    2015-01-01

    What does the use of cameras entail for the production of cultural critique in anthropology? Visual anthropological analysis and cultural critique starts at the very moment a camera is brought into the field or existing visual images are engaged. The framing, distances, and interactions between...... researchers, cameras, and filmed subjects already inherently comprise analytical decisions. It is these ethnographic qualities inherent in audiovisual and photographic imagery that make it of particular value to a participatory anthropological enterprise that seeks to resist analytic closure and seeks instead...

  5. Streak camera time calibration procedures

    Science.gov (United States)

    Long, J.; Jackson, I.

    1978-01-01

    Time calibration procedures for streak cameras utilizing a modulated laser beam are described. The time calibration determines a writing rate accuracy of 0.15% with a rotating mirror camera and 0.3% with an image converter camera.

  6. New methods of gamma-ray detection for radionuclide imaging

    International Nuclear Information System (INIS)

    Some new detection technologies of interest for medical radionuclide imaging are briefly considered. We limited our review to the following three modalities: standard size gamma camera for single photon imaging, miniature gamma camera for emission mammography, positron emission tomography and mammography (author)

  7. Advanced CCD camera developments

    Energy Technology Data Exchange (ETDEWEB)

    Condor, A. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    Two charge coupled device (CCD) camera systems are introduced and discussed, describing briefly the hardware involved, and the data obtained in their various applications. The Advanced Development Group Defense Sciences Engineering Division has been actively designing, manufacturing, fielding state-of-the-art CCD camera systems for over a decade. These systems were originally developed for the nuclear test program to record data from underground nuclear tests. Today, new and interesting application for these systems have surfaced and development is continuing in the area of advanced CCD camera systems, with the new CCD camera that will allow experimenters to replace film for x-ray imaging at the JANUS, USP, and NOVA laser facilities.

  8. The BCAM Camera

    CERN Document Server

    Hashemi, K S

    2000-01-01

    The BCAM, or Boston CCD Angle Monitor, is a camera looking at one or more light sources. We describe the application of the The BCAM, or Boston CCD Angle Monitor, is a camera looking at one or more light sources. We describe the application of the BCAM to the ATLAS forward muon detector alignment system. We show that the camera's performance is only weakly dependent upon the brightness, focus and diameter of the source image. Its resolution is dominated by turbulence along the external light path. The camera electronics is radiation-resistant. With a field of view of ± 10 mrad, it tracks the bearing of a light source 16 m away with better than 3 µrad accuracy, well within the ATLAS requirements.

  9. TARGETLESS CAMERA CALIBRATION

    Directory of Open Access Journals (Sweden)

    L. Barazzetti

    2012-09-01

    Full Text Available In photogrammetry a camera is considered calibrated if its interior orientation parameters are known. These encompass the principal distance, the principal point position and some Additional Parameters used to model possible systematic errors. The current state of the art for automated camera calibration relies on the use of coded targets to accurately determine the image correspondences. This paper presents a new methodology for the efficient and rigorous photogrammetric calibration of digital cameras which does not require any longer the use of targets. A set of images depicting a scene with a good texture are sufficient for the extraction of natural corresponding image points. These are automatically matched with feature-based approaches and robust estimation techniques. The successive photogrammetric bundle adjustment retrieves the unknown camera parameters and their theoretical accuracies. Examples, considerations and comparisons with real data and different case studies are illustrated to show the potentialities of the proposed methodology.

  10. Camera Calibration Using Silhouettes

    OpenAIRE

    Boyer, Edmond

    2005-01-01

    This report addresses the problem of estimating camera parameters from images where object silhouettes only are known. Several modeling applications make use of silhouettes, and while calibration methods are well known when considering points or lines matched along image sequences, the problem appears to be more difficult when considering silhouettes. However, such primitives encode also information on camera parameters by the fact that their associated viewing cones should present a common i...

  11. TOUCHSCREEN USING WEB CAMERA

    Directory of Open Access Journals (Sweden)

    Kuntal B. Adak

    2015-10-01

    Full Text Available In this paper we present a web camera based touchscreen system which uses a simple technique to detect and locate finger. We have used a camera and regular screen to achieve our goal. By capturing the video and calculating position of finger on the screen, we can determine the touch position and do some function on that location. Our method is very easy and simple to implement. Even our system requirement is less expensive compare to other techniques.

  12. Spacecraft camera image registration

    Science.gov (United States)

    Kamel, Ahmed A. (Inventor); Graul, Donald W. (Inventor); Chan, Fred N. T. (Inventor); Gamble, Donald W. (Inventor)

    1987-01-01

    A system for achieving spacecraft camera (1, 2) image registration comprises a portion external to the spacecraft and an image motion compensation system (IMCS) portion onboard the spacecraft. Within the IMCS, a computer (38) calculates an image registration compensation signal (60) which is sent to the scan control loops (84, 88, 94, 98) of the onboard cameras (1, 2). At the location external to the spacecraft, the long-term orbital and attitude perturbations on the spacecraft are modeled. Coefficients (K, A) from this model are periodically sent to the onboard computer (38) by means of a command unit (39). The coefficients (K, A) take into account observations of stars and landmarks made by the spacecraft cameras (1, 2) themselves. The computer (38) takes as inputs the updated coefficients (K, A) plus synchronization information indicating the mirror position (AZ, EL) of each of the spacecraft cameras (1, 2), operating mode, and starting and stopping status of the scan lines generated by these cameras (1, 2), and generates in response thereto the image registration compensation signal (60). The sources of periodic thermal errors on the spacecraft are discussed. The system is checked by calculating measurement residuals, the difference between the landmark and star locations predicted at the external location and the landmark and star locations as measured by the spacecraft cameras (1, 2).

  13. Central Acceptance Testing for Camera Technologies for CTA

    CERN Document Server

    Bonardi, A; Chadwick, P; Dazzi, F; Förster, A; Hörandel, J R; Punch, M

    2015-01-01

    The Cherenkov Telescope Array (CTA) is an international initiative to build the next generation ground based very-high energy gamma-ray observatory. It will consist of telescopes of three different sizes, employing several different technologies for the cameras that detect the Cherenkov light from the observed air showers. In order to ensure the compliance of each camera technology with CTA requirements, CTA will perform central acceptance testing of each camera technology. To assist with this, the Camera Test Facilities (CTF) work package is developing a detailed test program covering the most important performance, stability, and durability requirements, including setting up the necessary equipment. Performance testing will include a wide range of tests like signal amplitude, time resolution, dead-time determination, trigger efficiency, performance testing under temperature and humidity variations and several others. These tests can be performed on fully-integrated cameras using a portable setup at the came...

  14. CAOS-CMOS camera.

    Science.gov (United States)

    Riza, Nabeel A; La Torre, Juan Pablo; Amin, M Junaid

    2016-06-13

    Proposed and experimentally demonstrated is the CAOS-CMOS camera design that combines the coded access optical sensor (CAOS) imager platform with the CMOS multi-pixel optical sensor. The unique CAOS-CMOS camera engages the classic CMOS sensor light staring mode with the time-frequency-space agile pixel CAOS imager mode within one programmable optical unit to realize a high dynamic range imager for extreme light contrast conditions. The experimentally demonstrated CAOS-CMOS camera is built using a digital micromirror device, a silicon point-photo-detector with a variable gain amplifier, and a silicon CMOS sensor with a maximum rated 51.3 dB dynamic range. White light imaging of three different brightness simultaneously viewed targets, that is not possible by the CMOS sensor, is achieved by the CAOS-CMOS camera demonstrating an 82.06 dB dynamic range. Applications for the camera include industrial machine vision, welding, laser analysis, automotive, night vision, surveillance and multispectral military systems. PMID:27410361

  15. The Dark Energy Camera

    Energy Technology Data Exchange (ETDEWEB)

    Flaugher, B. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States). et al.

    2015-04-11

    The Dark Energy Camera is a new imager with a 2.2-degree diameter field of view mounted at the prime focus of the Victor M. Blanco 4-meter telescope on Cerro Tololo near La Serena, Chile. The camera was designed and constructed by the Dark Energy Survey Collaboration, and meets or exceeds the stringent requirements designed for the wide-field and supernova surveys for which the collaboration uses it. The camera consists of a five element optical corrector, seven filters, a shutter with a 60 cm aperture, and a CCD focal plane of 250-μm thick fully depleted CCDs cooled inside a vacuum Dewar. The 570 Mpixel focal plane comprises 62 2k x 4k CCDs for imaging and 12 2k x 2k CCDs for guiding and focus. The CCDs have 15μm x 15μm pixels with a plate scale of 0.263" per pixel. A hexapod system provides state-of-the-art focus and alignment capability. The camera is read out in 20 seconds with 6-9 electrons readout noise. This paper provides a technical description of the camera's engineering, construction, installation, and current status.

  16. The Dark Energy Camera

    CERN Document Server

    Flaugher, B; Honscheid, K; Abbott, T M C; Alvarez, O; Angstadt, R; Annis, J T; Antonik, M; Ballester, O; Beaufore, L; Bernstein, G M; Bernstein, R A; Bigelow, B; Bonati, M; Boprie, D; Brooks, D; Buckley-Geer, E J; Campa, J; Cardiel-Sas, L; Castander, F J; Castilla, J; Cease, H; Cela-Ruiz, J M; Chappa, S; Chi, E; Cooper, C; da Costa, L N; Dede, E; Derylo, G; DePoy, D L; de Vicente, J; Doel, P; Drlica-Wagner, A; Eiting, J; Elliott, A E; Emes, J; Estrada, J; Neto, A Fausti; Finley, D A; Flores, R; Frieman, J; Gerdes, D; Gladders, M D; Gregory, B; Gutierrez, G R; Hao, J; Holland, S E; Holm, S; Huffman, D; Jackson, C; James, D J; Jonas, M; Karcher, A; Karliner, I; Kent, S; Kessler, R; Kozlovsky, M; Kron, R G; Kubik, D; Kuehn, K; Kuhlmann, S; Kuk, K; Lahav, O; Lathrop, A; Lee, J; Levi, M E; Lewis, P; Li, T S; Mandrichenko, I; Marshall, J L; Martinez, G; Merritt, K W; Miquel, R; Munoz, F; Neilsen, E H; Nichol, R C; Nord, B; Ogando, R; Olsen, J; Palio, N; Patton, K; Peoples, J; Plazas, A A; Rauch, J; Reil, K; Rheault, J -P; Roe, N A; Rogers, H; Roodman, A; Sanchez, E; Scarpine, V; Schindler, R H; Schmidt, R; Schmitt, R; Schubnell, M; Schultz, K; Schurter, P; Scott, L; Serrano, S; Shaw, T M; Smith, R C; Soares-Santos, M; Stefanik, A; Stuermer, W; Suchyta, E; Sypniewski, A; Tarle, G; Thaler, J; Tighe, R; Tran, C; Tucker, D; Walker, A R; Wang, G; Watson, M; Weaverdyck, C; Wester, W; Woods, R; Yanny, B

    2015-01-01

    The Dark Energy Camera is a new imager with a 2.2-degree diameter field of view mounted at the prime focus of the Victor M. Blanco 4-meter telescope on Cerro Tololo near La Serena, Chile. The camera was designed and constructed by the Dark Energy Survey Collaboration, and meets or exceeds the stringent requirements designed for the wide-field and supernova surveys for which the collaboration uses it. The camera consists of a five element optical corrector, seven filters, a shutter with a 60 cm aperture, and a CCD focal plane of 250 micron thick fully-depleted CCDs cooled inside a vacuum Dewar. The 570 Mpixel focal plane comprises 62 2kx4k CCDs for imaging and 12 2kx2k CCDs for guiding and focus. The CCDs have 15 microns x15 microns pixels with a plate scale of 0.263 arc sec per pixel. A hexapod system provides state-of-the-art focus and alignment capability. The camera is read out in 20 seconds with 6-9 electrons readout noise. This paper provides a technical description of the camera's engineering, construct...

  17. Commercialization of radiation tolerant camera

    International Nuclear Information System (INIS)

    In this project, radiation tolerant camera which tolerates 106 - 108 rad total dose is developed. In order to develop radiation tolerant camera, radiation effect of camera components was examined and evaluated, and camera configuration was studied. By the result of evaluation, the components were decided and design was performed. Vidicon tube was selected to use by image sensor and non-browning optics and camera driving circuit were applied. The controller needed for CCTV camera system, lens, light, pan/tilt controller, was designed by the concept of remote control. And two type of radiation tolerant camera were fabricated consider to use in underwater environment or normal environment. (author)

  18. Fog camera to visualize ionizing charged particles

    International Nuclear Information System (INIS)

    The human being can not perceive the different types of ionizing radiation, natural or artificial, present in the nature, for what appropriate detection systems have been developed according to the sensibility to certain radiation type and certain energy type. The objective of this work was to build a fog camera to visualize the traces, and to identify the trajectories, produced by charged particles with high energy, coming mainly of the cosmic rays. The origin of the cosmic rays comes from the solar radiation generated by solar eruptions where the protons compose most of this radiation. It also comes, of the galactic radiation which is composed mainly of charged particles and gamma rays that comes from outside of the solar system. These radiation types have energy time millions higher that those detected in the earth surface, being more important as the height on the sea level increases. These particles in their interaction produce secondary particles that are detectable by means of this cameras type. The camera operates by means of a saturated atmosphere of alcohol vapor. In the moment in that a charged particle crosses the cold area of the atmosphere, the medium is ionized and the particle acts like a condensation nucleus of the alcohol vapor, leaving a visible trace of its trajectory. The built camera was very stable, allowing the detection in continuous form and the observation of diverse events. (Author)

  19. Camera Calibration: a USU Implementation

    OpenAIRE

    Ma, Lili; Chen, YangQuan; Moore, Kevin L.

    2003-01-01

    The task of camera calibration is to estimate the intrinsic and extrinsic parameters of a camera model. Though there are some restricted techniques to infer the 3-D information about the scene from uncalibrated cameras, effective camera calibration procedures will open up the possibility of using a wide range of existing algorithms for 3-D reconstruction and recognition. The applications of camera calibration include vision-based metrology, robust visual platooning and visual docking of mobil...

  20. Extrinsic recalibration in camera networks

    OpenAIRE

    Hermans, Chris; Dumont, Maarten; Bekaert, Philippe

    2007-01-01

    This work addresses the practical problem of keeping a camera network calibrated during a recording session. When dealing with real-time applications, a robust calibration of the camera network needs to be assured, without the burden of a full system recalibration at every (un)intended camera displacement. In this paper we present an efficient algorithm to detect when the extrinsic parameters of a camera are no longer valid, and reintegrate the displaced camera into the previously calibrated ...

  1. Selective-imaging camera

    Science.gov (United States)

    Szu, Harold; Hsu, Charles; Landa, Joseph; Cha, Jae H.; Krapels, Keith A.

    2015-05-01

    How can we design cameras that image selectively in Full Electro-Magnetic (FEM) spectra? Without selective imaging, we cannot use, for example, ordinary tourist cameras to see through fire, smoke, or other obscurants contributing to creating a Visually Degraded Environment (VDE). This paper addresses a possible new design of selective-imaging cameras at firmware level. The design is consistent with physics of the irreversible thermodynamics of Boltzmann's molecular entropy. It enables imaging in appropriate FEM spectra for sensing through the VDE, and displaying in color spectra for Human Visual System (HVS). We sense within the spectra the largest entropy value of obscurants such as fire, smoke, etc. Then we apply a smart firmware implementation of Blind Sources Separation (BSS) to separate all entropy sources associated with specific Kelvin temperatures. Finally, we recompose the scene using specific RGB colors constrained by the HVS, by up/down shifting Planck spectra at each pixel and time.

  2. Very high energy gamma ray astrophysics

    International Nuclear Information System (INIS)

    The Whipple Observatory High Resolution Camera will be used in a vigorous program of observations to search for new sources of very-high-energy gamma rays. In addition, a search for antimatter using the moon-earth system as an ion spectrometer will be begun. The first phase of GRANITE, the new 37-element 11-m camera, will be concluded with first light scheduled for September, 1991. The two cameras will operate in support of the Gamma Ray Observatory mission in the winter of 1991/2

  3. "Stereo Compton cameras" for the 3-D localization of radioisotopes

    Science.gov (United States)

    Takeuchi, K.; Kataoka, J.; Nishiyama, T.; Fujita, T.; Kishimoto, A.; Ohsuka, S.; Nakamura, S.; Adachi, S.; Hirayanagi, M.; Uchiyama, T.; Ishikawa, Y.; Kato, T.

    2014-11-01

    The Compton camera is a viable and convenient tool used to visualize the distribution of radioactive isotopes that emit gamma rays. After the nuclear disaster in Fukushima in 2011, there is a particularly urgent need to develop "gamma cameras", which can visualize the distribution of such radioisotopes. In response, we propose a portable Compton camera, which comprises 3-D position-sensitive GAGG scintillators coupled with thin monolithic MPPC arrays. The pulse-height ratio of two MPPC-arrays allocated at both ends of the scintillator block determines the depth of interaction (DOI), which dramatically improves the position resolution of the scintillation detectors. We report on the detailed optimization of the detector design, based on Geant4 simulation. The results indicate that detection efficiency reaches up to 0.54%, or more than 10 times that of other cameras being tested in Fukushima, along with a moderate angular resolution of 8.1° (FWHM). By applying the triangular surveying method, we also propose a new concept for the stereo measurement of gamma rays by using two Compton cameras, thus enabling the 3-D positional measurement of radioactive isotopes for the first time. From one point source simulation data, we ensured that the source position and the distance to the same could be determined typically to within 2 meters' accuracy and we also confirmed that more than two sources are clearly separated by the event selection from two point sources of simulation data.

  4. Automatic Camera Control

    DEFF Research Database (Denmark)

    Burelli, Paolo; Preuss, Mike

    2014-01-01

    Automatically generating computer animations is a challenging and complex problem with applications in games and film production. In this paper, we investigate howto translate a shot list for a virtual scene into a series of virtual camera configurations — i.e automatically controlling the virtual...... camera. We approach this problem by modelling it as a dynamic multi-objective optimisation problem and show how this metaphor allows a much richer expressiveness than a classical single objective approach. Finally, we showcase the application of a multi-objective evolutionary algorithm to generate a shot...

  5. Artificial human vision camera

    Science.gov (United States)

    Goudou, J.-F.; Maggio, S.; Fagno, M.

    2014-10-01

    In this paper we present a real-time vision system modeling the human vision system. Our purpose is to inspire from human vision bio-mechanics to improve robotic capabilities for tasks such as objects detection and tracking. This work describes first the bio-mechanical discrepancies between human vision and classic cameras and the retinal processing stage that takes place in the eye, before the optic nerve. The second part describes our implementation of these principles on a 3-camera optical, mechanical and software model of the human eyes and associated bio-inspired attention model.

  6. The Star Formation Camera

    OpenAIRE

    Scowen, Paul A.; Jansen, Rolf; Beasley, Matthew; Calzetti, Daniela; Desch, Steven; Fullerton, Alex; Gallagher, John; Lisman, Doug; Macenka, Steve; Malhotra, Sangeeta; McCaughrean, Mark; Nikzad, Shouleh; O'Connell, Robert; Oey, Sally; Padgett, Deborah

    2009-01-01

    The Star Formation Camera (SFC) is a wide-field (~15'x19, >280 arcmin^2), high-resolution (18x18 mas pixels) UV/optical dichroic camera designed for the Theia 4-m space-borne space telescope concept. SFC will deliver diffraction-limited images at lambda > 300 nm in both a blue (190-517nm) and a red (517-1075nm) channel simultaneously. Our aim is to conduct a comprehensive and systematic study of the astrophysical processes and environments relevant for the births and life cycles of stars and ...

  7. Limited-angle imaging in positron cameras: theory and practice

    International Nuclear Information System (INIS)

    The principles of operation of planar positron camera systems made up of multiwire proportional chambers as detectors and electromagnetic delay lines for coordinate readout are discussed. Gamma converters are coupled to the wire chambers to increase detection efficiency and improve spatial resolution. The conversion efficiencies of these converters are calculated and the results compare favorably to the experimentally measured values

  8. First experiences with acceptance testing of multiple head SPECT cameras

    International Nuclear Information System (INIS)

    User acceptance testing of newly installed gamma cameras is mandatory in order to verify manufacturers' specifications and to ensure optimal image quality. Acceptance test procedures are widely standardized today and are carried out following commonly accepted test protocols. Two new triple head gamma cameras have been installed during the last year at the Department of Nuclear Medicine of the Vienna University Hospital. For acceptance testing of these cameras a modified and expanded version of the commonly used test protocol for single head SPECT systems has been employed. Details of the tests that have been carried out and a comparison of the results obtained for both cameras are presented. Furthermore, some specific problems that are encountered during acceptance testing of multiple head systems are discussed. In particular it has been noted that some important tests of intrinsic camera parameters cannot be carried out, which makes a complete verification of vendors' specifications impossible. In spite of these problems the acceptance test system for multiple head cameras presented in this work was sufficient for establishing proper working conditions for clinical use. (authors)

  9. Performance evaluation of a pixellated Ge Compton camera

    Energy Technology Data Exchange (ETDEWEB)

    Alnaaimi, M A; Royle, G J; Ghoggali, W; Banoqitah, E; Speller, R D [Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT (United Kingdom); Cullum, I, E-mail: m.alnaaimi@medphys.ucl.ac.uk [Institute of Nuclear Medicine, University College London Hospital, London NW1 2BU (United Kingdom)

    2011-06-21

    An ongoing project is being carried out to develop a high purity germanium (HPGe) Compton camera for medical applications. The Compton camera offers many potential advantages over the conventional gamma camera. The camera reported in this paper comprises two pixellated germanium detector planes housed 9.6 cm apart in the same vacuum housing. The camera has 177 pixels, 152 in the scatter detector and 25 in the absorption detector. The pixels are 4 x 4 mm{sup 2} with a thickness of 4 mm in the scatter detector and 10 mm in the absorption detector. Images have been taken for a variety of test objects including point sources, a ring source and a Perspex phantom. The measured angular resolution is 9.4{sup 0} {+-} 0.4{sup 0} for a 662 keV gamma-ray source at 3 cm. Due to the limited number of readout modules a multiple-view technique was used to image the source distributions from different angles and simulate the pixel arrangement in the full camera.

  10. Opinion rating of comparison photographs of television pictures from CCD cameras under irradiation

    International Nuclear Information System (INIS)

    As part of the development of a general method of testing the effects of gamma radiation on CCD television cameras, this is a report of an experimental study on the optimisation of still photographic representation of video pictures recorded before and during camera irradiation. (author)

  11. Advanced Virgo phase cameras

    Science.gov (United States)

    van der Schaaf, L.; Agatsuma, K.; van Beuzekom, M.; Gebyehu, M.; van den Brand, J.

    2016-05-01

    A century after the prediction of gravitational waves, detectors have reached the sensitivity needed to proof their existence. One of them, the Virgo interferometer in Pisa, is presently being upgraded to Advanced Virgo (AdV) and will come into operation in 2016. The power stored in the interferometer arms raises from 20 to 700 kW. This increase is expected to introduce higher order modes in the beam, which could reduce the circulating power in the interferometer, limiting the sensitivity of the instrument. To suppress these higher-order modes, the core optics of Advanced Virgo is equipped with a thermal compensation system. Phase cameras, monitoring the real-time status of the beam constitute a critical component of this compensation system. These cameras measure the phases and amplitudes of the laser-light fields at the frequencies selected to control the interferometer. The measurement combines heterodyne detection with a scan of the wave front over a photodetector with pin-hole aperture. Three cameras observe the phase front of these laser sidebands. Two of them monitor the in-and output of the interferometer arms and the third one is used in the control of the aberrations introduced by the power recycling cavity. In this paper the working principle of the phase cameras is explained and some characteristic parameters are described.

  12. Make a Pinhole Camera

    Science.gov (United States)

    Fisher, Diane K.; Novati, Alexander

    2009-01-01

    On Earth, using ordinary visible light, one can create a single image of light recorded over time. Of course a movie or video is light recorded over time, but it is a series of instantaneous snapshots, rather than light and time both recorded on the same medium. A pinhole camera, which is simple to make out of ordinary materials and using ordinary…

  13. Photogrammetric camera calibration

    Science.gov (United States)

    Tayman, W.P.; Ziemann, H.

    1984-01-01

    Section 2 (Calibration) of the document "Recommended Procedures for Calibrating Photogrammetric Cameras and Related Optical Tests" from the International Archives of Photogrammetry, Vol. XIII, Part 4, is reviewed in the light of recent practical work, and suggestions for changes are made. These suggestions are intended as a basis for a further discussion. ?? 1984.

  14. Communities, Cameras, and Conservation

    Science.gov (United States)

    Patterson, Barbara

    2012-01-01

    Communities, Cameras, and Conservation (CCC) is the most exciting and valuable program the author has seen in her 30 years of teaching field science courses. In this citizen science project, students and community volunteers collect data on mountain lions ("Puma concolor") at four natural areas and public parks along the Front Range of Colorado.…

  15. The LSST Camera Overview

    Energy Technology Data Exchange (ETDEWEB)

    Gilmore, Kirk; Kahn, Steven A.; Nordby, Martin; Burke, David; O' Connor, Paul; Oliver, John; Radeka, Veljko; Schalk, Terry; Schindler, Rafe; /SLAC

    2007-01-10

    The LSST camera is a wide-field optical (0.35-1um) imager designed to provide a 3.5 degree FOV with better than 0.2 arcsecond sampling. The detector format will be a circular mosaic providing approximately 3.2 Gigapixels per image. The camera includes a filter mechanism and, shuttering capability. It is positioned in the middle of the telescope where cross-sectional area is constrained by optical vignetting and heat dissipation must be controlled to limit thermal gradients in the optical beam. The fast, f/1.2 beam will require tight tolerances on the focal plane mechanical assembly. The focal plane array operates at a temperature of approximately -100 C to achieve desired detector performance. The focal plane array is contained within an evacuated cryostat, which incorporates detector front-end electronics and thermal control. The cryostat lens serves as an entrance window and vacuum seal for the cryostat. Similarly, the camera body lens serves as an entrance window and gas seal for the camera housing, which is filled with a suitable gas to provide the operating environment for the shutter and filter change mechanisms. The filter carousel can accommodate 5 filters, each 75 cm in diameter, for rapid exchange without external intervention.

  16. The world's fastest camera

    CERN Multimedia

    Piquepaille, Roland

    2006-01-01

    This image processor is not your typical digital camera. It took 6 years to 20 people and $6 million to build the "Regional Calorimeter Trigger"(RCT) which will be a component of the Compact Muon Solenoid (CMS) experiment, one of the detectors on the Large Hadron Collider (LHC) in Geneva, Switzerland (1 page)

  17. Image Sensors Enhance Camera Technologies

    Science.gov (United States)

    2010-01-01

    In the 1990s, a Jet Propulsion Laboratory team led by Eric Fossum researched ways of improving complementary metal-oxide semiconductor (CMOS) image sensors in order to miniaturize cameras on spacecraft while maintaining scientific image quality. Fossum s team founded a company to commercialize the resulting CMOS active pixel sensor. Now called the Aptina Imaging Corporation, based in San Jose, California, the company has shipped over 1 billion sensors for use in applications such as digital cameras, camera phones, Web cameras, and automotive cameras. Today, one of every three cell phone cameras on the planet feature Aptina s sensor technology.

  18. MISR radiometric camera-by-camera Cloud Mask V004

    Data.gov (United States)

    National Aeronautics and Space Administration — This file contains the Radiometric camera-by-camera Cloud Mask dataset. It is used to determine whether a scene is classified as clear or cloudy. A new parameter...

  19. The first GCT camera for the Cherenkov Telescope Array

    CERN Document Server

    De Franco, A.; Allan, D.; Armstrong, T.; Ashton, T.; Balzer, A.; Berge, D.; Bose, R.; Brown, A.M.; Buckley, J.; Chadwick, P.M.; Cooke, P.; Cotter, G.; Daniel, M.K.; Funk, S.; Greenshaw, T.; Hinton, J.; Kraus, M.; Lapington, J.; Molyneux, P.; Moore, P.; Nolan, S.; Okumura, A.; Ross, D.; Rulten, C.; Schmoll, J.; Schoorlemmer, H.; Stephan, M.; Sutcliffe, P.; Tajima, H.; Thornhill, J.; Tibaldo, L.; Varner, G.; Watson, J.; Zink, A.

    2015-01-01

    The Gamma Cherenkov Telescope (GCT) is proposed to be part of the Small Size Telescope (SST) array of the Cherenkov Telescope Array (CTA). The GCT dual-mirror optical design allows the use of a compact camera of diameter roughly 0.4 m. The curved focal plane is equipped with 2048 pixels of ~0.2{\\deg} angular size, resulting in a field of view of ~9{\\deg}. The GCT camera is designed to record the flashes of Cherenkov light from electromagnetic cascades, which last only a few tens of nanoseconds. Modules based on custom ASICs provide the required fast electronics, facilitating sampling and digitisation as well as first level of triggering. The first GCT camera prototype is currently being commissioned in the UK. On-telescope tests are planned later this year. Here we give a detailed description of the camera prototype and present recent progress with testing and commissioning.

  20. Dual cameras acquisition and display system of retina-like sensor camera and rectangular sensor camera

    Science.gov (United States)

    Cao, Nan; Cao, Fengmei; Lin, Yabin; Bai, Tingzhu; Song, Shengyu

    2015-04-01

    For a new kind of retina-like senor camera and a traditional rectangular sensor camera, dual cameras acquisition and display system need to be built. We introduce the principle and the development of retina-like senor. Image coordinates transformation and interpolation based on sub-pixel interpolation need to be realized for our retina-like sensor's special pixels distribution. The hardware platform is composed of retina-like senor camera, rectangular sensor camera, image grabber and PC. Combined the MIL and OpenCV library, the software program is composed in VC++ on VS 2010. Experience results show that the system can realizes two cameras' acquisition and display.

  1. Automated Camera Array Fine Calibration

    Science.gov (United States)

    Clouse, Daniel; Padgett, Curtis; Ansar, Adnan; Cheng, Yang

    2008-01-01

    Using aerial imagery, the JPL FineCalibration (JPL FineCal) software automatically tunes a set of existing CAHVOR camera models for an array of cameras. The software finds matching features in the overlap region between images from adjacent cameras, and uses these features to refine the camera models. It is not necessary to take special imagery of a known target and no surveying is required. JPL FineCal was developed for use with an aerial, persistent surveillance platform.

  2. Camera Surveillance Quadrotor

    OpenAIRE

    Hjelm, Emil; Yousif, Robert

    2015-01-01

    A quadrotor is a helicopter with four rotors placed at equal distance from the crafts centre of gravity, controlled by letting the different rotors generate different amount of thrust. It uses various sensors to stay stable in the air, correct readings from these sensors are therefore critical. By reducing vibrations, electromagnetic interference and external disturbances the quadrotor’s stability can increase. The purpose of this project is to analyse the feasibility of a quadrotor camera su...

  3. Images processing in hostile nuclear environments. Experimental CCD cameras tests results for robotic operations

    International Nuclear Information System (INIS)

    This paper describes succinctly the hostile aspect of nuclear environment for visual sensors and transmissions. It approaches the new field of nuclear Robotic and its constraints about vision process. Tolerance tests of CCD cameras in gamma radiations environment are displayed: - gamma dosimetry measures, - electrical measurement process, - views during testing, - degradations and better tolerance hypothesis

  4. The Star Formation Camera

    CERN Document Server

    Scowen, Paul A; Beasley, Matthew; Calzetti, Daniela; Desch, Steven; Fullerton, Alex; Gallagher, John; Lisman, Doug; Macenka, Steve; Malhotra, Sangeeta; McCaughrean, Mark; Nikzad, Shouleh; O'Connell, Robert; Oey, Sally; Padgett, Deborah; Rhoads, James; Roberge, Aki; Siegmund, Oswald; Shaklan, Stuart; Smith, Nathan; Stern, Daniel; Tumlinson, Jason; Windhorst, Rogier; Woodruff, Robert

    2009-01-01

    The Star Formation Camera (SFC) is a wide-field (~15'x19, >280 arcmin^2), high-resolution (18x18 mas pixels) UV/optical dichroic camera designed for the Theia 4-m space-borne space telescope concept. SFC will deliver diffraction-limited images at lambda > 300 nm in both a blue (190-517nm) and a red (517-1075nm) channel simultaneously. Our aim is to conduct a comprehensive and systematic study of the astrophysical processes and environments relevant for the births and life cycles of stars and their planetary systems, and to investigate and understand the range of environments, feedback mechanisms, and other factors that most affect the outcome of the star and planet formation process. This program addresses the origins and evolution of stars, galaxies, and cosmic structure and has direct relevance for the formation and survival of planetary systems like our Solar System and planets like Earth. We present the design and performance specifications resulting from the implementation study of the camera, conducted ...

  5. SPECT detectors: the Anger Camera and beyond.

    Science.gov (United States)

    Peterson, Todd E; Furenlid, Lars R

    2011-09-01

    The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous sodium iodide scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic. PMID:21828904

  6. SPECT detectors: the Anger Camera and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Todd E [Institute of Imaging Science, Department of Radiology and Radiological Sciences, Department of Physics, and Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN (United States); Furenlid, Lars R, E-mail: todd.e.peterson@vanderbilt.edu [Center for Gamma-Ray Imaging, Department of Radiology, and College of Optical Sciences, University of Arizona, Tucson, AZ (United States)

    2011-09-07

    The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous sodium iodide scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic. (topical review)

  7. Two-detector, 512-element high purity germanium camera prototype

    International Nuclear Information System (INIS)

    A gamma-ray camera consisting of two 3.2 x 3.2 x 1-cm3 HPGe detectors has been assembled. Shallow orthogonal grooves define 512 2 x 2-mm2 elements. Square hole collimators have been fabricated with design parameters that exploit the unique characteristics of the detector. Intrinsic spatial resolution is a square function with 2-mm width, and energy resolution is approximately 2.5% FWHM at 140 keV. Evidently superior images are obtained when this instrument is compared to state-of-the-art scintillation cameras. 17 refs

  8. PAU camera: detectors characterization

    Science.gov (United States)

    Casas, Ricard; Ballester, Otger; Cardiel-Sas, Laia; Castilla, Javier; Jiménez, Jorge; Maiorino, Marino; Pío, Cristóbal; Sevilla, Ignacio; de Vicente, Juan

    2012-07-01

    The PAU Camera (PAUCam) [1,2] is a wide field camera that will be mounted at the corrected prime focus of the William Herschel Telescope (Observatorio del Roque de los Muchachos, Canary Islands, Spain) in the next months. The focal plane of PAUCam is composed by a mosaic of 18 CCD detectors of 2,048 x 4,176 pixels each one with a pixel size of 15 microns, manufactured by Hamamatsu Photonics K. K. This mosaic covers a field of view (FoV) of 60 arcmin (minutes of arc), 40 of them are unvignetted. The behaviour of these 18 devices, plus four spares, and their electronic response should be characterized and optimized for the use in PAUCam. This job is being carried out in the laboratories of the ICE/IFAE and the CIEMAT. The electronic optimization of the CCD detectors is being carried out by means of an OG (Output Gate) scan and maximizing it CTE (Charge Transfer Efficiency) while the read-out noise is minimized. The device characterization itself is obtained with different tests. The photon transfer curve (PTC) that allows to obtain the electronic gain, the linearity vs. light stimulus, the full-well capacity and the cosmetic defects. The read-out noise, the dark current, the stability vs. temperature and the light remanence.

  9. Stereoscopic camera design

    Science.gov (United States)

    Montgomery, David J.; Jones, Christopher K.; Stewart, James N.; Smith, Alan

    2002-05-01

    It is clear from the literature that the majority of work in stereoscopic imaging is directed towards the development of modern stereoscopic displays. As costs come down, wider public interest in this technology is expected to increase. This new technology would require new methods of image formation. Advances in stereo computer graphics will of course lead to the creation of new stereo computer games, graphics in films etc. However, the consumer would also like to see real-world stereoscopic images, pictures of family, holiday snaps etc. Such scenery would have wide ranges of depth to accommodate and would need also to cope with moving objects, such as cars, and in particular other people. Thus, the consumer acceptance of auto/stereoscopic displays and 3D in general would be greatly enhanced by the existence of a quality stereoscopic camera. This paper will cover an analysis of existing stereoscopic camera designs and show that they can be categorized into four different types, with inherent advantages and disadvantages. A recommendation is then made with regard to 3D consumer still and video photography. The paper will go on to discuss this recommendation and describe its advantages and how it can be realized in practice.

  10. A Compton camera application for the GAMOS GEANT4-based framework

    Science.gov (United States)

    Harkness, L. J.; Arce, P.; Judson, D. S.; Boston, A. J.; Boston, H. C.; Cresswell, J. R.; Dormand, J.; Jones, M.; Nolan, P. J.; Sampson, J. A.; Scraggs, D. P.; Sweeney, A.; Lazarus, I.; Simpson, J.

    2012-04-01

    Compton camera systems can be used to image sources of gamma radiation in a variety of applications such as nuclear medicine, homeland security and nuclear decommissioning. To locate gamma-ray sources, a Compton camera employs electronic collimation, utilising Compton kinematics to reconstruct the paths of gamma rays which interact within the detectors. The main benefit of this technique is the ability to accurately identify and locate sources of gamma radiation within a wide field of view, vastly improving the efficiency and specificity over existing devices. Potential advantages of this imaging technique, along with advances in detector technology, have brought about a rapidly expanding area of research into the optimisation of Compton camera systems, which relies on significant input from Monte-Carlo simulations. In this paper, the functionality of a Compton camera application that has been integrated into GAMOS, the GEANT4-based Architecture for Medicine-Oriented Simulations, is described. The application simplifies the use of GEANT4 for Monte-Carlo investigations by employing a script based language and plug-in technology. To demonstrate the use of the Compton camera application, simulated data have been generated using the GAMOS application and acquired through experiment for a preliminary validation, using a Compton camera configured with double sided high purity germanium strip detectors. Energy spectra and reconstructed images for the data sets are presented.

  11. Radiation damage of the PCO Pixelfly VGA CCD camera of the BES system on KSTAR tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Náfrádi, Gábor, E-mail: nafradi@reak.bme.hu [NTI, BME, EURATOM Association, H-1111 Budapest (Hungary); Kovácsik, Ákos, E-mail: kovacsik.akos@reak.bme.hu [NTI, BME, EURATOM Association, H-1111 Budapest (Hungary); Pór, Gábor, E-mail: por@reak.bme.hu [NTI, BME, EURATOM Association, H-1111 Budapest (Hungary); Lampert, Máté, E-mail: lampert.mate@wigner.mta.hu [Wigner RCP, RMI, EURATOM Association, POB 49, 1525 Budapest (Hungary); Un Nam, Yong, E-mail: yunam@nfri.re.kr [NFRI, 169-148 Gwahak-Ro, Yuseong-Gu, Daejeon 305-806 (Korea, Republic of); Zoletnik, Sándor, E-mail: zoletnik.sandor@wigner.mta.hu [Wigner RCP, RMI, EURATOM Association, POB 49, 1525 Budapest (Hungary)

    2015-01-11

    A PCO Pixelfly VGA CCD camera which is part a of the Beam Emission Spectroscopy (BES) diagnostic system of the Korea Superconducting Tokamak Advanced Research (KSTAR) used for spatial calibrations, suffered from serious radiation damage, white pixel defects have been generated in it. The main goal of this work was to identify the origin of the radiation damage and to give solutions to avoid it. Monte Carlo N-Particle eXtended (MCNPX) model was built using Monte Carlo Modeling Interface Program (MCAM) and calculations were carried out to predict the neutron and gamma-ray fields in the camera position. Besides the MCNPX calculations pure gamma-ray irradiations of the CCD camera were carried out in the Training Reactor of BME. Before, during and after the irradiations numerous frames were taken with the camera with 5 s long exposure times. The evaluation of these frames showed that with the applied high gamma-ray dose (1.7 Gy) and dose rate levels (up to 2 Gy/h) the number of the white pixels did not increase. We have found that the origin of the white pixel generation was the neutron-induced thermal hopping of the electrons which means that in the future only neutron shielding is necessary around the CCD camera. Another solution could be to replace the CCD camera with a more radiation tolerant one for example with a suitable CMOS camera or apply both solutions simultaneously.

  12. A system of gamma ray imaging devices with coded apertures

    Directory of Open Access Journals (Sweden)

    Papadimitropoulos Christos

    2016-01-01

    Full Text Available We describe a system consisting of two CdTe based gamma cameras with coded apertures and a video camera. The system is used for the localization of radioactive sources with the aid of triangulation. The methods used and the performance of the system are analyzed.

  13. A compact neutron scatter camera for field deployment.

    Science.gov (United States)

    Goldsmith, John E M; Gerling, Mark D; Brennan, James S

    2016-08-01

    We describe a very compact (0.9 m high, 0.4 m diameter, 40 kg) battery operable neutron scatter camera designed for field deployment. Unlike most other systems, the configuration of the sixteen liquid-scintillator detection cells are arranged to provide omnidirectional (4π) imaging with sensitivity comparable to a conventional two-plane system. Although designed primarily to operate as a neutron scatter camera for localizing energetic neutron sources, it also functions as a Compton camera for localizing gamma sources. In addition to describing the radionuclide source localization capabilities of this system, we demonstrate how it provides neutron spectra that can distinguish plutonium metal from plutonium oxide sources, in addition to the easier task of distinguishing AmBe from fission sources. PMID:27587113

  14. A portable Si/CdTe Compton camera and its applications to the visualization of radioactive substances

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Shin' ichiro, E-mail: takeda@astro.isas.jaxa.jp [Institute of Space and Astronautical Science (ISAS)/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Harayama, Atsushi [Institute of Space and Astronautical Science (ISAS)/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Ichinohe, Yuto [Institute of Space and Astronautical Science (ISAS)/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan); Odaka, Hirokazu [Institute of Space and Astronautical Science (ISAS)/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); Watanabe, Shin; Takahashi, Tadayuki [Institute of Space and Astronautical Science (ISAS)/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan); University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan); Tajima, Hiroyasu [Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601 (Japan); Genba, Kei; Matsuura, Daisuke; Ikebuchi, Hiroshi; Kuroda, Yoshikatsu [Mitsubishi Heavy Industries, 1200 Higashi-Tanaka, Komaki, Aichi 485-8561 (Japan); Tomonaka, Tetsuya [Mitsubishi Heavy Industry, 2-1-1 Shinhama, Arai-cho, Takasago, Hyogo 676-8686 (Japan)

    2015-07-01

    Gamma-ray imagers with the potential for visualizing the distribution of radioactive materials are required in the fields of astrophysics, medicine, nuclear applications, and homeland security. Based on the technology of the Si/CdTe Compton camera, we have manufactured the first commercial Compton camera for practical use. Through field tests in Fukushima, we demonstrated that the camera is capable of hot spot detection and the evaluation of radioactive decontamination.

  15. Collimated trans-axial tomographic scintillation camera

    International Nuclear Information System (INIS)

    The principal problem in trans-axial tomographic radioisotope scanning is the length of time required to obtain meaningful data. Patient movement and radioisotope migration during the scanning period can cause distortion of the image. The object of this invention is to reduce the scanning time without degrading the images obtained. A system is described in which a scintillation camera detector is moved to an orbit about the cranial-caudal axis relative to the patient. A collimator is used in which lead septa are arranged so as to admit gamma rays travelling perpendicular to this axis with high spatial resolution and those travelling in the direction of the axis with low spatial resolution, thus increasing the rate of acceptance of radioactive events to contribute to the positional information obtainable without sacrificing spatial resolution. (author)

  16. LISS-4 camera for Resourcesat

    Science.gov (United States)

    Paul, Sandip; Dave, Himanshu; Dewan, Chirag; Kumar, Pradeep; Sansowa, Satwinder Singh; Dave, Amit; Sharma, B. N.; Verma, Anurag

    2006-12-01

    The Indian Remote Sensing Satellites use indigenously developed high resolution cameras for generating data related to vegetation, landform /geomorphic and geological boundaries. This data from this camera is used for working out maps at 1:12500 scale for national level policy development for town planning, vegetation etc. The LISS-4 Camera was launched onboard Resourcesat-1 satellite by ISRO in 2003. LISS-4 is a high-resolution multi-spectral camera with three spectral bands and having a resolution of 5.8m and swath of 23Km from 817 Km altitude. The panchromatic mode provides a swath of 70Km and 5-day revisit. This paper briefly discusses the configuration of LISS-4 Camera of Resourcesat-1, its onboard performance and also the changes in the Camera being developed for Resourcesat-2. LISS-4 camera images the earth in push-broom mode. It is designed around a three mirror un-obscured telescope, three linear 12-K CCDs and associated electronics for each band. Three spectral bands are realized by splitting the focal plane in along track direction using an isosceles prism. High-speed Camera Electronics is designed for each detector with 12- bit digitization and digital double sampling of video. Seven bit data selected from 10 MSBs data by Telecommand is transmitted. The total dynamic range of the sensor covers up to 100% albedo. The camera structure has heritage of IRS- 1C/D. The optical elements are precisely glued to specially designed flexure mounts. The camera is assembled onto a rotating deck on spacecraft to facilitate +/- 26° steering in Pitch-Yaw plane. The camera is held on spacecraft in a stowed condition before deployment. The excellent imageries from LISS-4 Camera onboard Resourcesat-1 are routinely used worldwide. Such second Camera is being developed for Resourcesat-2 launch in 2007 with similar performance. The Camera electronics is optimized and miniaturized. The size and weight are reduced to one third and the power to half of the values in Resourcesat

  17. Correction of response defects in scintillation cameras by an on-line microcomputer

    International Nuclear Information System (INIS)

    A fast microprocessor device has been developed, to allow removal of non-linearity and non-uniformity effects of gamma camera signals. It slips in between a commercial gamma camera and the associated data processing system. Camera signals are digitized by fast ADC and numerically processed in real time. Corrected data are given analogic to be taken into account by process device associated to the camera. The principle is first to correct energy spatial variations by using coefficients determinated during calibration by a uniform radioactive distribution source. Then non-linearity of X and Y signals are removed by translations of them. The displacement coefficient table is given from reference images of parallel line phantom

  18. Development of SED Camera for Quasars in Early Universe (SQUEAN)

    CERN Document Server

    Kim, Sanghyuk; Lee, Hye-In; Park, Woojin; Ji, Tae-Geun; Hyun, Minhee; Choi, Changsu; Im, Myungshin; Pak, Soojong

    2016-01-01

    We describe the characteristics and performance of a camera system, Spectral energy distribution Camera for Quasars in Early Universe (SQUEAN). It was developed to measure SEDs of high redshift quasar candidates (z $\\gtrsim$ 5) and other targets, e.g., young stellar objects, supernovae, and gamma-ray bursts, and to trace the time variability of SEDs of objects such as active galactic nuclei (AGNs). SQUEAN consists of an on-axis focal plane camera module, an auto-guiding system, and mechanical supporting structures. The science camera module is composed of a focal reducer, a customizable filter wheel, and a CCD camera on the focal plane. The filter wheel uses filter cartridges that can house filters with different shapes and sizes, enabling the filter wheel to hold twenty filters of 50 mm $\\times$ 50 mm size, ten filters of 86 mm $\\times$ 86 mm size, or many other combinations. The initial filter mask was applied to calibrate the filter wheel with high accuracy and we verified that the filter position is repea...

  19. Evaluation of exposure to ionizing radiation among gamma camera operators

    OpenAIRE

    Agnieszka Anna Domańska; Małgorzata Bieńkiewicz; Jerzy Olszewski

    2013-01-01

    Background: Protection of nuclear medicine unit employees from hazards of the ionizing radiation is a crucial issue of radiation protection services. We aimed to assess the severity of the occupational radiation exposure of technicians performing scintigraphic examinations at the Nuclear Medicine Department, Central Teaching Hospital of Medical University in Łódź, where thousands of different diagnostic procedures are performed yearly. Materials and Methods: In 2013 the studied diagnostic uni...

  20. Evaluation of exposure to ionizing radiation among gamma camera operators

    Directory of Open Access Journals (Sweden)

    Agnieszka Anna Domańska

    2013-08-01

    Full Text Available Background: Protection of nuclear medicine unit employees from hazards of the ionizing radiation is a crucial issue of radiation protection services. We aimed to assess the severity of the occupational radiation exposure of technicians performing scintigraphic examinations at the Nuclear Medicine Department, Central Teaching Hospital of Medical University in Łódź, where thousands of different diagnostic procedures are performed yearly. Materials and Methods: In 2013 the studied diagnostic unit has employed 10 technicians, whose exposure is permanently monitored by individual dosimetry. We analyzed retrospective data of quarterly doses in terms of Hp(10 dose equivalents over the years 2001-2010. Also annual and five-year doses were determined to relate the results to current regulations. Moreover, for a selected period of one year, we collected data on the total activity of radiopharmaceuticals used for diagnostics, to analyze potential relationship with doses recorded in technicians performing the examinations. Results: In a 10-year period under study, the highest annual dose recorded in a technician was 2 mSv, which represented 10% of the annual dose limit of 20 mSv. The highest total dose for a 5-year period was 7.1 mSv, less than 10% of a 5-year dose limit for occupational exposure. Positive linear correlation was observed between total activity of radiopharmaceuticals used for diagnostics in the period of three months and respective quarterly doses received by technicians performing examinations. Conclusions: Doses received by nuclear medicine technicians performing diagnostic procedures in compliance with principles of radiation protection are low, which is confirmed by recognizing the technicians of this unit as B category employees. Med Pr 2013;64(4:503–506