WorldWideScience

Sample records for breakthrough operational problems

  1. (Mis)understanding Science: The Problem with Scientific Breakthroughs.

    Science.gov (United States)

    Evans, James P

    2016-09-01

    On Saturday morning, February 28, 1953, the mystery of heredity appeared secure. Humans hadn't the faintest idea of how genetic information was transmitted-how the uncanny resemblance between mother and daughter, grandfather and grandson was conveyed across generations. Yet, by that Saturday afternoon, two individuals, James Watson and Francis Crick, had glimpsed the solution to these mysteries. The story of Watson and Crick's great triumph has been told and retold and has rightly entered the pantheon of scientific legend. But Watson and Crick's breakthrough was just that: a rupture and dramatic discontinuity in human knowledge that solved a deep mystery, the likes of which occurs, perhaps, a couple of times each century. And that's the problem. The story is just so good and so irresistible that it has misled generations of scientists about what to expect regarding a life in science. And more damaging, the resulting breakthrough mentality misleads the public, the media, and society's decision-makers about how science really works, all to the detriment of scientific progress and our society's well-being. © 2016 The Hastings Center.

  2. PREFACE: Inverse Problems in Applied Sciences—towards breakthrough

    Science.gov (United States)

    Cheng, Jin; Iso, Yuusuke; Nakamura, Gen; Yamamoto, Masahiro

    2007-06-01

    These are the proceedings of the international conference `Inverse Problems in Applied Sciences—towards breakthrough' which was held at Hokkaido University, Sapporo, Japan on 3-7 July 2006 (http://coe.math.sci.hokudai.ac.jp/sympo/inverse/). There were 88 presentations and more than 100 participants, and we are proud to say that the conference was very successful. Nowadays, many new activities on inverse problems are flourishing at many centers of research around the world, and the conference has successfully gathered a world-wide variety of researchers. We believe that this volume contains not only main papers, but also conveys the general status of current research into inverse problems. This conference was the third biennial international conference on inverse problems, the core of which is the Pan-Pacific Asian area. The purpose of this series of conferences is to establish and develop constant international collaboration, especially among the Pan-Pacific Asian countries, and to lead the organization of activities concerning inverse problems centered in East Asia. The first conference was held at City University of Hong Kong in January 2002 and the second was held at Fudan University in June 2004. Following the preceding two successes, the third conference was organized in order to extend the scope of activities and build useful bridges to the next conference in Seoul in 2008. Therefore this third biennial conference was intended not only to establish collaboration and links between researchers in Asia and leading researchers worldwide in inverse problems but also to nurture interdisciplinary collaboration in theoretical fields such as mathematics, applied fields and evolving aspects of inverse problems. For these purposes, we organized tutorial lectures, serial lectures and a panel discussion as well as conference research presentations. This volume contains three lecture notes from the tutorial and serial lectures, and 22 papers. Especially at this

  3. On generalized operator quasi-equilibrium problems

    Science.gov (United States)

    Kum, Sangho; Kim, Won Kyu

    2008-09-01

    In this paper, we will introduce the generalized operator equilibrium problem and generalized operator quasi-equilibrium problem which generalize the operator equilibrium problem due to Kazmi and Raouf [K.R. Kazmi, A. Raouf, A class of operator equilibrium problems, J. Math. Anal. Appl. 308 (2005) 554-564] into multi-valued and quasi-equilibrium problems. Using a Fan-Browder type fixed point theorem in [S. Park, Foundations of the KKM theory via coincidences of composites of upper semicontinuous maps, J. Korean Math. Soc. 31 (1994) 493-519] and an existence theorem of equilibrium for 1-person game in [X.-P. Ding, W.K. Kim, K.-K. Tan, Equilibria of non-compact generalized games with L*-majorized preferences, J. Math. Anal. Appl. 164 (1992) 508-517] as basic tools, we prove new existence theorems on generalized operator equilibrium problem and generalized operator quasi-equilibrium problem which includes operator equilibrium problems.

  4. Creating breakthroughs at 3M.

    Science.gov (United States)

    von Hippel, E; Thomke, S; Sonnack, M

    1999-01-01

    Most senior managers want their product development teams to create break-throughs--new products that will allow their companies to grow rapidly and maintain high margins. But more often they get incremental improvements to existing products. That's partly because companies must compete in the short term. Searching for breakthroughs is expensive and time consuming; line extensions can help the bottom line immediately. In addition, developers simply don't know how to achieve breakthroughs, and there is usually no system in place to guide them. By the mid-1990s, the lack of such a system was a problem even for an innovative company like 3M. Then a project team in 3M's Medical-Surgical Markets Division became acquainted with a method for developing breakthrough products: the lead user process. The process is based on the fact that many commercially important products are initially thought of and even prototyped by "lead users"--companies, organizations, or individuals that are well ahead of market trends. Their needs are so far beyond those of the average user that lead users create innovations on their own that may later contribute to commercially attractive breakthroughs. The lead user process transforms the job of inventing breakthroughs into a systematic task of identifying lead users and learning from them. The authors explain the process and how the 3M project team successfully navigated through it. In the end, the team proposed three major new product lines and a change in the division's strategy that has led to the development of breakthrough products. And now several more divisions are using the process to break away from incrementalism.

  5. Operator approximant problems arising from quantum theory

    CERN Document Server

    Maher, Philip J

    2017-01-01

    This book offers an account of a number of aspects of operator theory, mainly developed since the 1980s, whose problems have their roots in quantum theory. The research presented is in non-commutative operator approximation theory or, to use Halmos' terminology, in operator approximants. Focusing on the concept of approximants, this self-contained book is suitable for graduate courses.

  6. Breakthrough cancer pain

    DEFF Research Database (Denmark)

    Davies, Andrew; Buchanan, Alison; Zeppetella, Giovambattista

    2013-01-01

    Breakthrough pain is common in patients with cancer and is a significant cause of morbidity in this group of patients.......Breakthrough pain is common in patients with cancer and is a significant cause of morbidity in this group of patients....

  7. Equivalent operator preconditioning for elliptic problems

    Czech Academy of Sciences Publication Activity Database

    Axelsson, Owe; Karátson, J.

    2009-01-01

    Roč. 50, č. 3 (2009), s. 297-380 ISSN 1017-1398 Institutional research plan: CEZ:AV0Z30860518 Keywords : Elliptic problem * Conjugate gradient method * preconditioning * equivalent operators * compact operators Subject RIV: BA - General Mathematics Impact factor: 0.716, year: 2009 http://en.scientificcommons.org/42514649

  8. Operations research problems statements and solutions

    CERN Document Server

    Poler, Raúl; Díaz-Madroñero, Manuel

    2014-01-01

    The objective of this book is to provide a valuable compendium of problems as a reference for undergraduate and graduate students, faculty, researchers and practitioners of operations research and management science. These problems can serve as a basis for the development or study of assignments and exams. Also, they can be useful as a guide for the first stage of the model formulation, i.e. the definition of a problem. The book is divided into 11 chapters that address the following topics: Linear programming, integer programming, non linear programming, network modeling, inventory theory, queue theory, tree decision, game theory, dynamic programming and markov processes. Readers are going to find a considerable number of statements of operations research applications for management decision-making. The solutions of these problems are provided in a concise way although all topics start with a more developed resolution. The proposed problems are based on the research experience of the authors in real-world com...

  9. Operating experience feedback report - Solenoid-operated valve problems

    International Nuclear Information System (INIS)

    Ornstein, H.L.

    1991-02-01

    This report highlights significant operating events involving observed or potential common-mode failures of solenoid-operated valves (SOVs) in US plants. These events resulted in degradation or malfunction of multiple trains of safety systems as well as of multiple safety systems. On the basis of the evaluation of these events, the Office for Analysis and Evaluation of Operational Data (AEOD) of the US Nuclear Regulatory Commission (NRC) concludes that the problems with solenoid-operated valves are an important issue that needs additional NRC and industry attention. This report also provides AEOD's recommendations for actions to reduce the occurrence of SOV common-mode failures. 115 refs., 7 figs., 2 tabs

  10. Frames, operator representations, and open problems

    DEFF Research Database (Denmark)

    Christensen, Ole; Hasannasab, Marzieh

    2018-01-01

    , a topic that has recently attracted considerably interest within harmonic analysis. The goal of the paper is twofold, namely, that experts in operator theory will explore the potential of frames, and that frame theory will benefit from insight provided by the operator theory community.......A frame in a Hilbert space H is a countable collection of elements in H that allows each f ϵ H to be expanded as an (infinite) linear combination of the frame elements. Frames generalize the wellknown orthonormal bases, but provide much more exibility and can often be constructed with properties...... that are not possible for orthonormal bases. We will present the basic facts in frame theory with focus on their operator theoretical characterizations and discuss open problems concerning representations of frames in terms of iterations of a fixed operator. These problems come up in the context of dynamical sampling...

  11. Operation problems as viewed by EDF

    International Nuclear Information System (INIS)

    Cheimanoff, Andre; Gaborit, Jean; Thom, Roger

    1983-01-01

    The installation of a plant such as Eurodif, whose power will reach, when fully operational, a maximum of 3,200 MW, and of a nuclear power plant of 4x900 MW, such as the one located in the Tricastin area, has considerable effects on the structure and operation of the EDF's network, both at the national and regional levels. The paper presents the situation regarding the Tricastin-Eurodif complex in the context of the EDF's network, the main operation problems that are encountered and the organization that had to be created to tackle these problems. Finally, it affords the opportunity to give an appreciation of the situation about the operation of the complex in 1982 [fr

  12. Sulfur impact on NO{sub x} storage, oxygen storage, and ammonia breakthrough during cyclic lean/rich operation of a commercial lean NO{sub x} trap

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jae-Soon; Partridge, William P.; Daw, C. Stuart [Fuels, Engines, and Emissions Research Center, Oak Ridge National Laboratory, P.O. Box 2008, MS-6472, Oak Ridge, TN 37831-6472 (United States)

    2007-11-30

    The objective of the present study was to develop an improved understanding of how sulfur affects the spatiotemporal distribution of reactions and temperature inside a monolithic lean NO{sub x} trap (LNT). These spatiotemporal distributions are believed to be major factors in LNT function, and thus, we expect that a better understanding of these phenomena can benefit the design and operation of commercial LNTs. In our study, we experimentally evaluated a commercial LNT monolith installed in a bench-flow reactor with simulated engine exhaust. The reactor feed gas composition was cycled to simulate fast lean/rich LNT operation at 325 C, and spatiotemporal species and temperature profiles were monitored along the LNT axis at different sulfur loadings. Reactor outlet NO{sub x}, NO, N{sub 2}O, and NH{sub 3} were also measured. Sulfur tended to accumulate in a plug-like fashion in the reactor and progressively inhibited NO{sub x} storage capacity along the axis. The NO{sub x} storage/reduction (NSR) reactions occurred over a relatively short portion of the reactor (NSR zone) under the conditions used in this study, and thus, net NO{sub x} conversion was only significantly reduced at high sulfur loading. Oxygen storage capacity (OSC) was poisoned by sulfur also in a progressive manner but to a lesser extent than the NO{sub x} storage capacity. Global selectivity for N{sub 2}O remained low at all sulfur loadings, but NH{sub 3} selectivity increased significantly with sulfur loading. We conjecture that NH{sub 3} breakthrough increased because of decreasing oxidation of NH{sub 3}, slipping from the NSR zone, by downstream stored oxygen. The NSR and oxygen storage/reduction (OSR) generated distinctive exotherms during the rich phase and at the rich/lean transition. Exotherm locations shifted downstream with sulfur accumulation in a manner that was consistent with the progressive poisoning of NSR and OSR sites. (author)

  13. Motor operated valves problems tests and simulations

    Energy Technology Data Exchange (ETDEWEB)

    Pinier, D.; Haas, J.L.

    1996-12-01

    An analysis of the two refusals of operation of the EAS recirculation shutoff valves enabled two distinct problems to be identified on the motorized valves: the calculation methods for the operating torques of valves in use in the power plants are not conservative enough, which results in the misadjustement of the torque limiters installed on their motorizations, the second problem concerns the pressure locking phenomenon: a number of valves may entrap a pressure exceeding the in-line pressure between the disks, which may cause a jamming of the valve. EDF has made the following approach to settle the first problem: determination of the friction coefficients and the efficiency of the valve and its actuator through general and specific tests and models, definition of a new calculation method. In order to solve the second problem, EDF has made the following operations: identification of the valves whose technology enables the pressure to be entrapped: the tests and numerical simulations carried out in the Research and Development Division confirm the possibility of a {open_quotes}boiler{close_quotes} effect: determination of the necessary modifications: development and testing of anti-boiler effect systems.

  14. Motor operated valves problems tests and simulations

    International Nuclear Information System (INIS)

    Pinier, D.; Haas, J.L.

    1996-01-01

    An analysis of the two refusals of operation of the EAS recirculation shutoff valves enabled two distinct problems to be identified on the motorized valves: the calculation methods for the operating torques of valves in use in the power plants are not conservative enough, which results in the misadjustement of the torque limiters installed on their motorizations, the second problem concerns the pressure locking phenomenon: a number of valves may entrap a pressure exceeding the in-line pressure between the disks, which may cause a jamming of the valve. EDF has made the following approach to settle the first problem: determination of the friction coefficients and the efficiency of the valve and its actuator through general and specific tests and models, definition of a new calculation method. In order to solve the second problem, EDF has made the following operations: identification of the valves whose technology enables the pressure to be entrapped: the tests and numerical simulations carried out in the Research and Development Division confirm the possibility of a open-quotes boilerclose quotes effect: determination of the necessary modifications: development and testing of anti-boiler effect systems

  15. Operating experience feedback report - Air systems problems

    International Nuclear Information System (INIS)

    Ornstein, H.L.

    1987-12-01

    This report highlights significant operating events involving observed or potential failures of safety-related systems in U.S. plants that resulted from degraded or malfunctioning non-safety grade air systems. Based upon the evaluation of these events, the Office for Analysis and Evaluation of Operational Data (AEOD) concludes that the issue of air systems problems is an important one which requires additional NRC and industry attention. This report also provides AEOD's recommendations for corrective actions to deal with the issue. (author)

  16. Some threshold spectral problems of Schroedinger operators

    International Nuclear Information System (INIS)

    Jia, X.

    2009-01-01

    This Ph.D. thesis deals with some spectral problems of the Schroedinger operators. We first consider the semi-classical limit of the number of bound states of unique two-cluster N-body Schroedinger operator. Then we use Dirichlet-Neumann bracket to get semi-classical limit of Riesz means of the discrete eigenvalues of N-body Schroedinger operator. The effective potential of N-body Schroedinger operator with Coulomb potential is also considered and we find that the effective potential has critical decay at infinity. Thus, the Schroedinger operator with critical potential is studied in this thesis. We study the coupling constant threshold of Schroedinger operator with critical potential and the asymptotic expansion of resolvent of Schroedinger operator with critical potential. We use that expansion to study low-energy asymptotics of derivative of spectral shift function for perturbation with critical decay. After that, we use this result and the known result for high-energy asymptotic expansion of spectral shift function to obtain the Levinson theorem. (author)

  17. Quadratic stochastic operators: Results and open problems

    International Nuclear Information System (INIS)

    Ganikhodzhaev, R.N.; Rozikov, U.A.

    2009-03-01

    The history of the quadratic stochastic operators can be traced back to the work of S. Bernshtein (1924). For more than 80 years this theory has been developed and many papers were published. In recent years it has again become of interest in connection with numerous applications in many branches of mathematics, biology and physics. But most results of the theory were published in non English journals, full text of which are not accessible. In this paper we give a brief description of the results and discuss several open problems. (author)

  18. A split operator method for transient problems

    International Nuclear Information System (INIS)

    Belytschko, T.B.

    1983-01-01

    Numerous techniques have been developed for improving the computational efficiency of transient analysis: mesh partitioning, subcycling procedures and operator splitting methods. In mesh partitioning methods, the model is divided into subdomains which are integrated by different time integrators, typically implicit and explicit. Any stiff portions of the model are integrated by the implicit operator so that the size of the time step can be increased. In subcycling procedures, the stiff portions are integrated by smaller time steps, yielding similar benefits. However, in models for which the governing partial differential equations are basically of a parabolic character, explicit methods can become quite expensive for refined models because the size of the stable time step decreases with the square of the minimum element dimension. Thus explicit methods, whether employed alone or with partitioning or subcycling, have inherent limitations in these problems. A new procedure is here described for the element-by-element semi-implicit method of Hughes and coworkers which requires the solution of only small systems of equations. This procedure is described for a family of uniform gradient or strain elements which are widely used in nonlinear transient analysis. The diffusion equation and the equations of motion for both shells and continua have been treated, but only the former is considered herein. Results are presented for several examples which show the potential of this method for improving the efficiency of a large-scale linear and nonlinear computations. (orig./RW)

  19. Breakthroughs in statistics

    CERN Document Server

    Johnson, Norman

    This is author-approved bcc: This is the third volume of a collection of seminal papers in the statistical sciences written during the past 110 years. These papers have each had an outstanding influence on the development of statistical theory and practice over the last century. Each paper is preceded by an introduction written by an authority in the field providing background information and assessing its influence. Volume III concerntrates on articles from the 1980's while including some earlier articles not included in Volume I and II. Samuel Kotz is Professor of Statistics in the College of Business and Management at the University of Maryland. Norman L. Johnson is Professor Emeritus of Statistics at the University of North Carolina. Also available: Breakthroughs in Statistics Volume I: Foundations and Basic Theory Samuel Kotz and Norman L. Johnson, Editors 1993. 631 pp. Softcover. ISBN 0-387-94037-5 Breakthroughs in Statistics Volume II: Methodology and Distribution Samuel Kotz and Norman L. Johnson, Edi...

  20. Aviation safety and operation problems research and technology

    Science.gov (United States)

    Enders, J. H.; Strickle, J. W.

    1977-01-01

    Aircraft operating problems are described for aviation safety. It is shown that as aircraft technology improves, the knowledge and understanding of operating problems must also improve for economics, reliability and safety.

  1. Problems on triangular norms and related operators

    Czech Academy of Sciences Publication Activity Database

    Klement, E.P.; Mesiar, Radko; Pap, E.

    2004-01-01

    Roč. 23, č. 145 (2004), s. 471-479 ISSN 0165-0114 R&D Projects: GA ČR GA402/04/1026 Institutional research plan: CEZ:AV0Z1075907 Keywords : triangular norm * triangular conorm * aggregation operator Subject RIV: BA - General Mathematics Impact factor: 0.734, year: 2004

  2. Military Operational Research: the Sensor Coverage Problem

    NARCIS (Netherlands)

    Barros, A.I.; Koopmans, J.

    1999-01-01

    Military Operations Research is a field that has been growing since the Second World War, and in particular in the last decades. Within this vast area, Air Defence, the protection of the air space against an airborne threat, has become a hot topic. ln order to successfully protect a given zone

  3. Non-dense domain operator matrices and Cauchy problems

    International Nuclear Information System (INIS)

    Lalaoui Rhali, S.

    2002-12-01

    In this work, we study Cauchy problems with non-dense domain operator matrices. By assuming that the entries of an unbounded operator matrix are Hille-Yosida operators, we give a necessary and sufficient condition ensuring that the part of this operator matrix generates a semigroup in the closure of its domain. This allows us to prove the well-posedness of the corresponding Cauchy problem. Our results are applied to delay and neutral differential equations. (author)

  4. Problems with Interagency Integration in Contemporary Operations

    Science.gov (United States)

    2014-12-04

    also conducted other tasks that included providing security for NGO food distribution and creating a prioritized list of requirements. The Joint...operation moved into February. In several instances, United States military airdropped food and other resources into urban areas that 46 Guha-Sapir...Up to thirty percent of crops rotted in farmer’s fields due to insufficient road networks. They also identified electricity as critical. Over

  5. Computerized systems of NPP operators support. (Psychological problems)

    International Nuclear Information System (INIS)

    Mashin, V.A.

    1995-01-01

    Operator psychological problems arising in the work with NPP operators support computerized systems (OSCS) are considered. The conclusion is made that the OSCS intellectual application will bring the operator into dangerous dependence on his computerized assistant. To avoid this danger it is necessary by creation of the OSCS to divide specially the tasks areas of the operator and OSCS in order to assure the active role of the operator in the NPP control

  6. A breakthrough in the technical dust abatement in the mining operations of RAG; Durchbruch in der technischen Staubbekaempfung der RAG-Abbaubetriebe

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Klaus-Peter [Bezirksregierung Arnsberg, Gelsenkrichen (Germany). Dezernat 62; Suedhofer, Frank [RAG Aktiengesellschaft, Bottrop (Germany). Servicebereich Belegschaft - BB S1 Ergonomie/Umgebungseinfluesse

    2010-02-15

    In the years 2005 to 2007, the dust abatement in the mining operations of RAG AG (Bottrop, Federal Republic of Germany) fundamentally is regulated and standardised without a distinction between primary and secondary measures. In the contribution under consideration the authors report on measures and effects of the optimization of dust abatement in workings of the German coal mining. Positive developments of the dust load for the employees are stated on the basis of operational data.

  7. Limit, breakthrough and prosperity

    International Nuclear Information System (INIS)

    Takahashi, Minoru

    1973-01-01

    It is pointed out that the flow toward serious crises is in progress with regard to energy and industrial problems. Technical and industrial preparation and countermeasure to the flow are proposed, and the existence of a certain new world attainable on the assumption that the countermeasure is successful is described. The relation between oil output and the increasing demand for energy is pointed out as a subject matter of the crisis. The contribution of oil energy to total energy, after the output turns to decreasing process, decreases by 177.87x10 6 tons (converted to coal at the rate 6848 kcal/kg) per year at maximum. Converted to the GNP of the world, this becomes (425 dollar/ton x 177.87 x 10 6 ton=75.6 x 10 9 dollar). This fluctuation width in a year must be compensated by the change of industrial structure and energy supplying means. The countermeasure and preparation are proposed from the viewpoints of the energy and the industrial structure in which nuclear power generation plays important role. The largest production on the earth limited by energy consumption and the temperature balance on the earth is investigated, and the perspective in the future is given. (Yamamoto, Y.)

  8. Achieving a demographic breakthrough.

    Science.gov (United States)

    Taniguchi, H

    1994-09-01

    President Hosni Mubarak received the United Nations Population Award on June 14, 1994, because of his contribution to the promotion of the national population program in Egypt. Egypt has been tackling the population problem on three fronts: high rate of natural increase (2.3% in 1994), unbalanced population distribution along the Nile Valley and the Mediterranean coast that account for just 4% of the land, and insufficient educational and health levels. At present seven major programs are being implemented throughout the country to curb population increase involving information, education and communication; family planning; human resource development; improving maternal and child health, and educational level; increasing employment; the empowerment of women; and systematic land development. The total fertility rate dropped to 3.9 during 1990-1992 from 5.3 during 1979-1980. The crude birth rate dropped to 29.2/1000 population in 1992 from 38.7/1000 in 1986. The crude death rate also decreased to 7.4/1000 in 1992 from 9.2/1000 in 1986. The infant mortality rate decreased to 62 during 1988-1992 from 132 during 1975-1979. The contraceptive prevalence rate climbed from 24.25 in 1980 to 47.1% in 1992. The strong endorsement by the Grand Mufti that Islam supports family planning made many people change their traditional view that family planning was forbidden by the Koran. The political commitment from the President led to the provision of large budgets for the national population program. Technical and program assistance provided by donors including the United States Agency for International Development has greatly contributed to mass media campaigns and service delivery. 63.4% of acceptors received family planning services or contraceptives from the private sector. Egypt is willing to share its population and family planning experience with other developing countries that have similar economic and social conditions particularly if financial assistance by industrialized

  9. The inverse spectral problem for pencils of differential operators

    International Nuclear Information System (INIS)

    Guseinov, I M; Nabiev, I M

    2007-01-01

    The inverse problem of spectral analysis for a quadratic pencil of Sturm-Liouville operators on a finite interval is considered. A uniqueness theorem is proved, a solution algorithm is presented, and sufficient conditions for the solubility of the inverse problem are obtained. Bibliography: 31 titles.

  10. Some particular problems put by operating experimental reactors

    International Nuclear Information System (INIS)

    Candiotti, C.; Mabeix, R.; Uguen, R.

    1960-01-01

    On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [fr

  11. Setting and solving several factorization problems for integral operators

    International Nuclear Information System (INIS)

    Engibaryan, N B

    2000-01-01

    The problem of factorization I-K=(I-U - )(I-U + ), is considered. Here I is the identity operator, K is a fixed integral operator of Fredholm type: (Kf)(x)=∫ a b k(x,t)f(t)dt, -∞≤a ± are unknown upper and lower Volterra operators. Classes of generalized Volterra operators U ± are introduced such that I-U ± are not necessarily invertible operators in the spaces of functions on (a,b) under consideration. A combination of the method of non-linear factorization equations and a priori estimates brings forth new results on the existence and properties of the solution to this problem for k≥0, both in the subcritical case μ + and U - vanish on some parts S - and S + of the domain S=(a,b) 2 such that S + union S - =S

  12. Geostatistical regularization operators for geophysical inverse problems on irregular meshes

    Science.gov (United States)

    Jordi, C.; Doetsch, J.; Günther, T.; Schmelzbach, C.; Robertsson, J. OA

    2018-05-01

    Irregular meshes allow to include complicated subsurface structures into geophysical modelling and inverse problems. The non-uniqueness of these inverse problems requires appropriate regularization that can incorporate a priori information. However, defining regularization operators for irregular discretizations is not trivial. Different schemes for calculating smoothness operators on irregular meshes have been proposed. In contrast to classical regularization constraints that are only defined using the nearest neighbours of a cell, geostatistical operators include a larger neighbourhood around a particular cell. A correlation model defines the extent of the neighbourhood and allows to incorporate information about geological structures. We propose an approach to calculate geostatistical operators for inverse problems on irregular meshes by eigendecomposition of a covariance matrix that contains the a priori geological information. Using our approach, the calculation of the operator matrix becomes tractable for 3-D inverse problems on irregular meshes. We tested the performance of the geostatistical regularization operators and compared them against the results of anisotropic smoothing in inversions of 2-D surface synthetic electrical resistivity tomography (ERT) data as well as in the inversion of a realistic 3-D cross-well synthetic ERT scenario. The inversions of 2-D ERT and seismic traveltime field data with geostatistical regularization provide results that are in good accordance with the expected geology and thus facilitate their interpretation. In particular, for layered structures the geostatistical regularization provides geologically more plausible results compared to the anisotropic smoothness constraints.

  13. Spatially varying dispersion to model breakthrough curves.

    Science.gov (United States)

    Li, Guangquan

    2011-01-01

    Often the water flowing in a karst conduit is a combination of contaminated water entering at a sinkhole and cleaner water released from the limestone matrix. Transport processes in the conduit are controlled by advection, mixing (dilution and dispersion), and retention-release. In this article, a karst transport model considering advection, spatially varying dispersion, and dilution (from matrix seepage) is developed. Two approximate Green's functions are obtained using transformation of variables, respectively, for the initial-value problem and for the boundary-value problem. A numerical example illustrates that mixing associated with strong spatially varying conduit dispersion can cause strong skewness and long tailing in spring breakthrough curves. Comparison of the predicted breakthrough curve against that measured from a dye-tracing experiment between Ames Sink and Indian Spring, Northwest Florida, shows that the conduit dispersivity can be as large as 400 m. Such a large number is believed to imply strong solute interaction between the conduit and the matrix and/or multiple flow paths in a conduit network. It is concluded that Taylor dispersion is not dominant in transport in a karst conduit, and the complicated retention-release process between mobile- and immobile waters may be described by strong spatially varying conduit dispersion. Copyright © 2010 The Author(s). Journal compilation © 2010 National Ground Water Association.

  14. Visual Problems in Night Operations (Problemes de Vision dans les Operations de Nuit)

    Science.gov (United States)

    1992-05-01

    conference proceedings (FR) Progrqbs r~cents concernant l05 aides au pilote clans I habitacle d’un aaroi’ef milltaire en operations. Nouveau drone ...allleurs) traitelit doe la sophistication des La firme isra~lienne tAt teste un nouveau drone appel6 ’Impact’. tacnes domanda~es aus pilotes d-avionS- doe...une camara do tala6vision A vision nocturne. 151 met aussl relations liomlme-macfline.ces syst~mws (lndiff~remesmnt dasignds au point une station

  15. Problem Sets: Fundamentals Of Transportation And Traffic Operations

    OpenAIRE

    Daganzo, Carlos F.

    1998-01-01

    These problem sets comprise a supplement to Fundamentals of Transportation and Traffic Operations (C. Daganzo, Pergamon, 1997). Academicians can also obtain a companion set of solutions by writing to "Institute of Transportation Studies, Publications Office, 109 McLaughlin Hall, University of California, Berkeley, CA 94720" or by sending e-mail to .

  16. Problem-Based Learning for Production and Operations Management

    Science.gov (United States)

    Kanet, John J.; Barut, Mehmet

    2003-01-01

    In this paper, we describe our application of "problem-based learning" in the teaching of production/operations management. We describe a study of the effectiveness of this approach and present the results and analysis of this study. We provide a collection of our experiences in using this method and conclude with some general…

  17. Specific problems in Kozloduy municipality, concerning NPP operation and decommissioning

    International Nuclear Information System (INIS)

    Pironkova, L.

    2000-01-01

    The only nuclear power plant in Bulgaria, which operates for 25 years is located in Kozloduy. Kozloduy municipality is situated in the northern part of Danube plane, includes the administrative center and four villages. It is 200 km far from Sofia and 80 km from the regional center Vratza. The Kozloduy NPP operates 6 units of total capacity 3760 MW, producing more than 40% of the electricity needs in Bulgaria. Settled and recurring problems of the municipality are related to economic, geographical, demographic and administration issues. Future problems will be related to forthcoming reactor shutdown and decommissioning. This involves economic problems, possible bankruptcies of local firms servicing the NPP, decreasing budget and living standard, expected restrictions of social programs, increasing unemployment, possible changes in demographic structure of population

  18. [Major breakthroughs in the medical treatment

    DEFF Research Database (Denmark)

    Kirk, O.; Gerstoft, J.; Lundgren, J.D.

    2009-01-01

    The introduction of antiretroviral combination therapy for patients with HIV infection is described as an example of a breakthrough within the field of medical treatment. The background for the breakthrough and the phases thereof are described and for comparison, the circumstances of major breakt...... breakthroughs within other medical specialities are mentioned Udgivelsesdato: 2009/3/2......The introduction of antiretroviral combination therapy for patients with HIV infection is described as an example of a breakthrough within the field of medical treatment. The background for the breakthrough and the phases thereof are described and for comparison, the circumstances of major...

  19. A problem-solving routine for improving hospital operations.

    Science.gov (United States)

    Ghosh, Manimay; Sobek Ii, Durward K

    2015-01-01

    The purpose of this paper is to examine empirically why a systematic problem-solving routine can play an important role in the process improvement efforts of hospitals. Data on 18 process improvement cases were collected through semi-structured interviews, reports and other documents, and artifacts associated with the cases. The data were analyzed using a grounded theory approach. Adherence to all the steps of the problem-solving routine correlated to greater degrees of improvement across the sample. Analysis resulted in two models. The first partially explains why hospital workers tended to enact short-term solutions when faced with process-related problems; and tended not seek longer-term solutions that prevent problems from recurring. The second model highlights a set of self-reinforcing behaviors that are more likely to address problem recurrence and result in sustained process improvement. The study was conducted in one hospital setting. Hospital managers can improve patient care and increase operational efficiency by adopting and diffusing problem-solving routines that embody three key characteristics. This paper offers new insights on why caregivers adopt short-term approaches to problem solving. Three characteristics of an effective problem-solving routine in a healthcare setting are proposed.

  20. Aostra claims major oilsands breakthrough

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This paper reports that Alberta Oil Sands Technology and Research Authority (Aostra) has completed a horizontal well in-situ steam injection project it calls a major breakthrough in commercially producing bitumen from the bast Athabasca oilsands deposit in Alberta. Aostra the its $71 million (Canadian) proof of concept pilot underground test facility (UTF) near Fort McMurray, achieved a 60% bitumen recovery rate, compared with less than 20% recovery typically achieved with Alberta bitumen. More than 100,000 bbl of bitumen was produced during the project

  1. Computational approach to Thornley's problem by bivariate operational calculus

    Science.gov (United States)

    Bazhlekova, E.; Dimovski, I.

    2012-10-01

    Thornley's problem is an initial-boundary value problem with a nonlocal boundary condition for linear onedimensional reaction-diffusion equation, used as a mathematical model of spiral phyllotaxis in botany. Applying a bivariate operational calculus we find explicit representation of the solution, containing two convolution products of special solutions and the arbitrary initial and boundary functions. We use a non-classical convolution with respect to the space variable, extending in this way the classical Duhamel principle. The special solutions involved are represented in the form of fast convergent series. Numerical examples are considered to show the application of the present technique and to analyze the character of the solution.

  2. The Convergence Problems of Eigenfunction Expansions of Elliptic Differential Operators

    Science.gov (United States)

    Ahmedov, Anvarjon

    2018-03-01

    In the present research we investigate the problems concerning the almost everywhere convergence of multiple Fourier series summed over the elliptic levels in the classes of Liouville. The sufficient conditions for the almost everywhere convergence problems, which are most difficult problems in Harmonic analysis, are obtained. The methods of approximation by multiple Fourier series summed over elliptic curves are applied to obtain suitable estimations for the maximal operator of the spectral decompositions. Obtaining of such estimations involves very complicated calculations which depends on the functional structure of the classes of functions. The main idea on the proving the almost everywhere convergence of the eigenfunction expansions in the interpolation spaces is estimation of the maximal operator of the partial sums in the boundary classes and application of the interpolation Theorem of the family of linear operators. In the present work the maximal operator of the elliptic partial sums are estimated in the interpolation classes of Liouville and the almost everywhere convergence of the multiple Fourier series by elliptic summation methods are established. The considering multiple Fourier series as an eigenfunction expansions of the differential operators helps to translate the functional properties (for example smoothness) of the Liouville classes into Fourier coefficients of the functions which being expanded into such expansions. The sufficient conditions for convergence of the multiple Fourier series of functions from Liouville classes are obtained in terms of the smoothness and dimensions. Such results are highly effective in solving the boundary problems with periodic boundary conditions occurring in the spectral theory of differential operators. The investigations of multiple Fourier series in modern methods of harmonic analysis incorporates the wide use of methods from functional analysis, mathematical physics, modern operator theory and spectral

  3. Learning to Solve Problems by Searching for Macro-Operators

    Science.gov (United States)

    1983-07-01

    executing generalized robot plans. Aritificial Intelligence 3:25 1-288, 1972. [Frey 821 Frey, Alexander Ii. Jr., and David Singmaster. Handbook of Cubik...and that searching for macros may be a useful general learning paradigm. 1.1. Introduction One view of die die field of artificial intelligence is that... intelligence literature [Schofield 67, Gaschnig 79, Ericsson 761 and provides one of the simplest examples of the operation of the Macro Problem Solver. It

  4. Tax havens: Features, operations and solving tax evasion problems

    OpenAIRE

    Obradović-Ćuk, Jelena; Mitić, Petar; Dinić, Vladimir

    2016-01-01

    Tax haven offers minimal or no tax liability to foreign individuals and enterprises in economically and politically stable environment, where little or no financial information is shared with foreign tax authorities. The aim of this research is to create a comprehensive overview of the characteristics and operations of tax havens, as well as to point out to the ways to overcome the problem of tax evasion. The methodology used in the work is characteristic of social science research: analysis,...

  5. The operational flight and multi-crew scheduling problem

    Directory of Open Access Journals (Sweden)

    Stojković Mirela

    2005-01-01

    Full Text Available This paper introduces a new kind of operational multi-crew scheduling problem which consists in simultaneously modifying, as necessary, the existing flight departure times and planned individual work days (duties for the set of crew members, while respecting predefined aircraft itineraries. The splitting of a planned crew is allowed during a day of operations, where it is more important to cover a flight than to keep planned crew members together. The objective is to cover a maximum number of flights from a day of operations while minimizing changes in both the flight schedule and the next-day planned duties for the considered crew members. A new type of the same flight departure time constraints is introduced. They ensure that a flight which belongs to several personalized duties, where the number of duties is equal to the number of crew members assigned to the flight, will have the same departure time in each of these duties. Two variants of the problem are considered. The first variant allows covering of flights by less than the planned number of crew members, while the second one requires covering of flights by a complete crew. The problem is mathematically formulated as an integer nonlinear multi-commodity network flow model with time windows and supplementary constraints. The optimal solution approach is based on Dantzig-Wolfe decomposition/column generation embedded into a branch-and-bound scheme. The resulting computational times on commercial-size problems are very good. Our new simultaneous approach produces solutions whose quality is far better than that of the traditional sequential approach where the flight schedule has been changed first and then input as a fixed data to the crew scheduling problem.

  6. Recurring Utterances - Targeting a Breakthrough

    Directory of Open Access Journals (Sweden)

    Jacqueline Stark

    2014-05-01

    The most interesting phenomenon is KB’s production of words from former sessions indicating that they are still ‘active’ and the production of completely novel incorrect words. The observable features indicate that immediate auditory processing is possible in the form of repeating target words. However, as soon as KB must retrieve information from the (semantic lexicon, even after being able to correctly ‘repeat’ the target word several times, he responds with a RU, perseveration, or paraphasia. Several of his productions can be characterized as aphasic confabulations which stem from a memory gap. Thus, although KB’s language impairment is severe, his responses across time indicate that step-by-step a breakthrough is being made.

  7. Nuclear graphite development, operational problems, and resolution of these problems at the Hanford production reactors

    International Nuclear Information System (INIS)

    Morgan, W.C.

    1996-01-01

    This paper chronicles the history of the Hanford Production Reactor, from the initial design considerations for B, D, and F Reactors through the selection of the agreed method for safe disposal of the decommissioned reactors. The operational problems that challenged the operations and support staff of each new generation of production reactors, the engineering actions an operational changes that alleviated or resolved the immediate problems, the changes in reactor design and design-bases for the next generation of production reactors, and the changes in manufacturing variables that resulted in new ''improved'' grades of nuclear graphites for use in the moderators of the Hanford Production Reactors are reviewed in the context of the existing knowledge-base and the mission-driven priorities on the time. 14 refs, 6 figs, 3 tabs

  8. Tax havens: Features, operations and solving tax evasion problems

    Directory of Open Access Journals (Sweden)

    Obradović-Ćuk Jelena

    2016-01-01

    Full Text Available Tax haven offers minimal or no tax liability to foreign individuals and enterprises in economically and politically stable environment, where little or no financial information is shared with foreign tax authorities. The aim of this research is to create a comprehensive overview of the characteristics and operations of tax havens, as well as to point out to the ways to overcome the problem of tax evasion. The methodology used in the work is characteristic of social science research: analysis, synthesis and discussion, comparative, inductive and historical analysis, together with the usage of relevant national and international sources. This paper describes the basic features of tax havens, as well as specific business models applied in them. A separate chapter deals with overcoming the problem of tax evasion, which is the main adverse effect of doing business through tax havens.

  9. On Lambda and Time Operators: the Inverse Intertwining Problem Revisited

    Science.gov (United States)

    Gómez-Cubillo, F.; Suchanecki, Z.; Villullas, S.

    2011-07-01

    An exact theory of irreversibility was proposed by Misra, Prigogine and Courbage, based on non-unitary similarity transformations Λ that intertwine reversible dynamics and irreversible ones. This would advocate the idea that irreversible behavior would originate at the microscopic level. Reversible evolution with an internal time operator have the intertwining property. Recently the inverse intertwining problem has been answered in the negative, that is, not every unitary evolution allowing such Λ-transformation has an internal time. This work contributes new results in this direction.

  10. Spectral results for mixed problems and fractional elliptic operators,

    DEFF Research Database (Denmark)

    Grubb, Gerd

    2015-01-01

    In the first part of the paper we show Weyl type spectral asymptotic formulas for pseudodifferential operators P a of order 2a, with type and factorization index a  ∈ R +, restricted to compact sets with boundary; this includes fractional powers of the Laplace operator. The domain...... and the regularity of eigenfunctions is described. In the second part, we apply this in a study of realizations A χ,Σ+ in L 2( Ω ) of mixed problems for a second-order strongly elliptic symmetric differential operator A on a bounded smooth set Ω ⊂ R n; here the boundary ∂Ω=Σ is partioned smoothly into Σ......=Σ_∪Σ+, the Dirichlet condition γ0u=0 is imposed on Σ_, and a Neumann or Robin condition χu=0 is imposed on Σ+. It is shown that the Dirichlet-to-Neumann operator Pγ,χ is principally of type 1/2 with factorization index 1/2, relative to Σ+. The above theory allows a detailed description of D (Aχ,Σ_+) with singular...

  11. Inertial frames and breakthrough propulsion physics

    Science.gov (United States)

    Millis, Marc G.

    2017-09-01

    The term ;Breakthrough Propulsion Physics; comes from the NASA project by that name which examined non-rocket space drives, gravity control, and faster-than-light travel. The focus here is on space drives and the related unsolved physics of inertial frames. A ;space drive; is a generic term encompassing any concept for using as-yet undiscovered physics to move a spacecraft instead of existing rockets, sails, or tethers. The collective state of the art spans mostly steps 1-3 of the scientific method: defining the problem, collecting data, and forming hypotheses. The key issues include (1) conservation of momentum, (2) absence of obvious reaction mass, and (3) the net-external thrusting requirement. Relevant open problems in physics include: (1) the sources and mechanisms of inertial frames, (2) coupling of gravitation to the other fundamental forces, and (3) the nature of the quantum vacuum. Rather than following the assumption that inertial frames are an immutable, intrinsic property of space, this paper revisits Mach's Principle, where it is posited that inertia is relative to the distant surrounding matter. This perspective allows conjectures that a space drive could impart reaction forces to that matter, via some as-yet undiscovered interaction with the inertial frame properties of space. Thought experiments are offered to begin a process to derive new hypotheses. It is unknown if this line of inquiry will be fruitful, but it is hoped that, by revisiting unsolved physics from a propulsion point of view, new insights will be gained.

  12. Injection, injectivity and injectability in geothermal operations: problems and possible solutions. Phase I. Definition of the problems

    Energy Technology Data Exchange (ETDEWEB)

    Vetter, O.J.; Crichlow, H.B.

    1979-02-14

    The following topics are covered: thermodynamic instability of brine, injectivity loss during regular production and injection operations, injectivity loss caused by measures other than regular operations, heat mining and associated reservoir problems in reinjection, pressure maintenance through imported make-up water, suggested solutions to injection problems, and suggested solutions to injection problems: remedial and stimulation measures. (MHR)

  13. Applications of ordered weighted averaging (OWA operators in environmental problems

    Directory of Open Access Journals (Sweden)

    Carlos Llopis-Albert

    2017-04-01

    Full Text Available This paper presents an application of a prioritized weighted aggregation operator based on ordered weighted averaging (OWA to deal with stakeholders' constructive participation in water resources projects. They have different degree of acceptance or preference regarding the measures and policies to be carried out, which lead to different environmental and socio-economic outcomes, and hence, to different levels of stakeholders’ satisfaction. The methodology establishes a prioritization relationship upon the stakeholders, which preferences are aggregated by means of weights depending on the satisfaction of the higher priority policy maker. The methodology establishes a prioritization relationship upon the stakeholders, which preferences are aggregated by means of weights depending on the satisfaction of the higher priority policy maker. The methodology has been successfully applied to a Public Participation Project (PPP in watershed management, thus obtaining efficient environmental measures in conflict resolution problems under actors’ preference uncertainties.

  14. Decision support system for the operating room rescheduling problem.

    Science.gov (United States)

    van Essen, J Theresia; Hurink, Johann L; Hartholt, Woutske; van den Akker, Bernd J

    2012-12-01

    Due to surgery duration variability and arrivals of emergency surgeries, the planned Operating Room (OR) schedule is disrupted throughout the day which may lead to a change in the start time of the elective surgeries. These changes may result in undesirable situations for patients, wards or other involved departments, and therefore, the OR schedule has to be adjusted. In this paper, we develop a decision support system (DSS) which assists the OR manager in this decision by providing the three best adjusted OR schedules. The system considers the preferences of all involved stakeholders and only evaluates the OR schedules that satisfy the imposed resource constraints. The decision rules used for this system are based on a thorough analysis of the OR rescheduling problem. We model this problem as an Integer Linear Program (ILP) which objective is to minimize the deviation from the preferences of the considered stakeholders. By applying this ILP to instances from practice, we determined that the given preferences mainly lead to (i) shifting a surgery and (ii) scheduling a break between two surgeries. By using these changes in the DSS, the performed simulation study shows that less surgeries are canceled and patients and wards are more satisfied, but also that the perceived workload of several departments increases to compensate this. The system can also be used to judge the acceptability of a proposed initial OR schedule.

  15. [Breakthrough cancer pain in the elderly].

    Science.gov (United States)

    Cabezón-Gutiérrez, Luis; Viloria-Jiménez, María Aurora; Pérez-Cajaraville, Juan; Álamo-González, Cecilio; López-Trigo, José Antonio; Gil-Gregorio, Pedro

    Breakthrough pain is defined as an acute exacerbation of pain with rapid onset, short duration and moderate or high intensity, which occurs spontaneously or in connection with a predictable or unpredictable event despite there being stabilised and controlled baseline pain. However, there are doubts about the definition, terminology, epidemiology, and assessment of breakthrough pain, with no clear answers or consensus, especially in the elderly population. This non-systematic review summarises the most important aspects of breakthrough pain in the elderly, based on the limited publications there are in that population group. Copyright © 2016 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Modeling dust growth in protoplanetary disks: The breakthrough case

    Science.gov (United States)

    Drążkowska, J.; Windmark, F.; Dullemond, C. P.

    2014-07-01

    Context. Dust coagulation in protoplanetary disks is one of the initial steps toward planet formation. Simple toy models are often not sufficient to cover the complexity of the coagulation process, and a number of numerical approaches are therefore used, among which integration of the Smoluchowski equation and various versions of the Monte Carlo algorithm are the most popular. Aims: Recent progress in understanding the processes involved in dust coagulation have caused a need for benchmarking and comparison of various physical aspects of the coagulation process. In this paper, we directly compare the Smoluchowski and Monte Carlo approaches to show their advantages and disadvantages. Methods: We focus on the mechanism of planetesimal formation via sweep-up growth, which is a new and important aspect of the current planet formation theory. We use realistic test cases that implement a distribution in dust collision velocities. This allows a single collision between two grains to have a wide range of possible outcomes but also requires a very high numerical accuracy. Results: For most coagulation problems, we find a general agreement between the two approaches. However, for the sweep-up growth driven by the "lucky" breakthrough mechanism, the methods exhibit very different resolution dependencies. With too few mass bins, the Smoluchowski algorithm tends to overestimate the growth rate and the probability of breakthrough. The Monte Carlo method is less dependent on the number of particles in the growth timescale aspect but tends to underestimate the breakthrough chance due to its limited dynamic mass range. Conclusions: We find that the Smoluchowski approach, which is generally better for the breakthrough studies, is sensitive to low mass resolutions in the high-mass, low-number tail that is important in this scenario. To study the low number density features, a new modulation function has to be introduced to the interaction probabilities. As the minimum resolution

  17. Problems with veteran-family communication during operation enduring freedom/operation Iraqi freedom military deployment.

    Science.gov (United States)

    Hinojosa, Ramon; Hinojosa, Melanie Sberna; Högnäs, Robin S

    2012-02-01

    Twenty Reserve component (Army and Marines) and Army National Guard male veterans of Operational Enduring Freedom/Operation Iraqi Freedom discuss their deployment and postdeployment family reintegration experiences. A Grounded Theory approach is used to highlight some of the ways in which family miscommunication during deployment can occur. Communication with civilian family members is affected by the needs of operational security, technical problems with communication tools, miscommunication between family members, or because veterans have "nothing new to say" to family back home. These communication difficulties may lead to an initial gulf of understanding between veterans and family members that can cause family strain during postdeployment family reintegration. We end with a discussion of veteran family reintegration difficulties.

  18. Innovation Impact: Breakthrough Research Results (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-07-01

    The Innovation Impact brochure captures key breakthrough results across NREL's primary areas of renewable energy and energy efficiency research: solar, wind, bioenergy, transportation, buildings, analysis, and manufacturing technologies.

  19. The Breakthrough Behind the Chevy Volt Battery

    Science.gov (United States)

    Lerner, Louise

    2011-03-28

    A revolutionary breakthrough cathode for lithium-ion batteries—the kind in your cell phone, laptop and new hybrid cars—makes them last longer, run more safely and perform better than batteries currently on the market.

  20. Researchers Realize Major Breakthrough in Understanding Endometriosis

    Science.gov (United States)

    ... 16, 2014 Researchers Realize Major Breakthrough in Understanding Endometriosis For a disease that affects an estimated 6 ... 10% of women, surprisingly little is known about endometriosis — a disorder that causes uterine tissue to grow ...

  1. Radiation protection problems by the operation of the cyclotron facility

    International Nuclear Information System (INIS)

    Durcik, M.; Nikodemova, D.

    1998-01-01

    The Cyclotron Center in Bratislava will consist of two cyclotrons. First - cyclotron DC-72 with maximal energy of 72 MV for protons for making experiments, for teaching process, for radioisotope production as 123 I and for neutron and proton therapy. Second - compact cyclotron with maximal proton energy of 18 MeV will be used for radioisotopes production for medical diagnosis as 1 *F (fluorodeoxyglucose), 81 Rb/ 81 Kr generator. This paper deals with the radiation protection problems by the operation of tis cyclotron facility as radiation protection of workers, monitoring plan, ventilation, safety lock and limitation and radiation monitoring. For proposed and continuing practices at the accelerator facility, the following general principles have to be fulfilled: (1) practices should produce sufficient benefit to offset the radiation detriment they case (justification); (2) the magnitude of the individual doses should be kept as low as achievable (optimization of protection); (3) individual exposures are subject to dose limits and some control of risk from potential exposures (dose and risk limits)

  2. Application of Operational Research Techniques in Operating Room Scheduling Problems: Literature Overview

    Directory of Open Access Journals (Sweden)

    Şeyda Gür

    2018-01-01

    Full Text Available Increased healthcare costs are pushing hospitals to reduce costs and increase the quality of care. Operating rooms are the most important source of income and expense for hospitals. Therefore, the hospital management focuses on the effectiveness of schedules and plans. This study includes analyses of recent research on operating room scheduling and planning. Most studies in the literature, from 2000 to the present day, were evaluated according to patient characteristics, performance measures, solution techniques used in the research, the uncertainty of the problem, applicability of the research, and the planning strategy to be dealt within the solution. One hundred seventy studies were examined in detail, after scanning the Emerald, Science Direct, JSTOR, Springer, Taylor and Francis, and Google Scholar databases. To facilitate the identification of these studies, they are grouped according to the different criteria of concern and then, a detailed overview is presented.

  3. Prediction of ion-exchange column breakthrough curves by constant-pattern wave approach.

    Science.gov (United States)

    Lee, I-Hsien; Kuan, Yu-Chung; Chern, Jia-Ming

    2008-03-21

    The release of heavy metals from industrial wastewaters represents one of major threats to environment. Compared with chemical precipitation method, fixed-bed ion-exchange process can effectively remove heavy metals from wastewaters and generate no hazardous sludge. In order to design and operate fixed-bed ion-exchange processes successfully, it is very important to understand the column dynamics. In this study, the column experiments for Cu2+/H+, Zn2+/H+, and Cd2+/H+ systems using Amberlite IR-120 were performed to measure the breakthrough curves under varying operating conditions. The experimental results showed that total cation concentration in the mobile-phase played a key role on the breakthrough curves; a higher feed concentration resulted in an earlier breakthrough. Furthermore, the column dynamics was also predicted by self-sharpening and constant-pattern wave models. The self-sharpening wave model assuming local ion-exchange equilibrium could provide a simple and quick estimation for the breakthrough volume, but the predicted breakthrough curves did not match the experimental data very well. On the contrary, the constant-pattern wave model using a constant driving force model for finite ion-exchange rate provided a better fit to the experimental data. The obtained liquid-phase mass transfer coefficient was correlated to the flow velocity and other operating parameters; the breakthrough curves under varying operating conditions could thus be predicted by the constant-pattern wave model using the correlation.

  4. Use of pulsed-neutron capture logs to identify steam breakthrough

    International Nuclear Information System (INIS)

    Masse, P.J.; Gosney, T.C.; Long, D.L.

    1991-01-01

    This paper reports on identification of steam-breakthrough zones in a stacked sand/shale sequence with variable lateral continuity which is difficult. Such identification, however, would allow the modification of field operations to enhance recovery through improved vertical sweep and heat injection. Twenty pulsed-neutron capture (PNC) logs were run to identify the steam-breakthrough zone(s) in a seven-pattern area of Mobil's Middle expansion (MIDX) Steamflood Project in the South Belridge field. These PNC data were combined with data from recent replacement wells and a detailed geologic analysis. Evaluation of this combined information allowed identification of potential steam-breakthrough zone(s), and operations were modified to reduce and eliminate steam breakthrough

  5. Operational approach to the environmental problems in the developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Amsyari, F

    1980-01-01

    Environmental programs associated with socioeconomic development are examined. In most developing countries, environmental problems affecting human health are connected with poverty, over-population, and biological pollutants. An analysis of the environmental problems associated with socioeconomic development in Surabaya City, Indonesia, is presented. An analytical methodology and a mathematical model for an integrated environmental program are described. (1 diagram, 5 references, 5 tables)

  6. Applications of systems thinking and soft operations research in managing complexity from problem framing to problem solving

    CERN Document Server

    2016-01-01

    This book captures current trends and developments in the field of systems thinking and soft operations research which can be applied to solve today's problems of dynamic complexity and interdependency. Such ‘wicked problems’ and messes are seemingly intractable problems characterized as value-laden, ambiguous, and unstable, that resist being tamed by classical problem solving. Actions and interventions associated with this complex problem space can have highly unpredictable and unintended consequences. Examples of such complex problems include health care reform, global climate change, transnational serious and organized crime, terrorism, homeland security, human security, disaster management, and humanitarian aid. Moving towards the development of solutions to these complex problem spaces depends on the lens we use to examine them and how we frame the problem. It will be shown that systems thinking and soft operations research has had great success in contributing to the management of complexity. .

  7. Operational Reconnaissance: Identifying the Right Problems in a Complex World

    Science.gov (United States)

    2015-05-23

    velocity of human interactions and the diverse demographics among populations as having critical impacts on land operations. Understanding these can have a...Achtung Panzer! Translated by Christopher Duffy. London, England: Arms and Armour Press, 1995. Echevarria II, Antonio J. “American Operational Art

  8. Operator ordering and supersymmetry (an old problem becomes new)

    International Nuclear Information System (INIS)

    De Alfaro, V.; Fubini, S.; Roncadelli, M.; Furlan, G.

    1987-11-01

    Supersymmetric quantum mechanics in curved space is investigated. The role of supersymmetry and of invariance under general coordinate transformation in solving the operator ordering ambiguity is discussed. 8 refs

  9. Flipped Instruction: Breakthroughs in Research and Practice

    Science.gov (United States)

    IGI Global, 2017

    2017-01-01

    The integration of technology into modern classrooms has enhanced learning opportunities for students. With increased access to educational content, students gain a better understanding of the concepts being taught. "Flipped Instruction: Breakthroughs in Research and Practice" is a comprehensive reference source for the latest scholarly…

  10. Exploring the Market for Breakthrough Technologies

    NARCIS (Netherlands)

    Ortt, J. Roland; Langley, David J.; Pals, Nico

    In this article, the gap between futures research (long term) and market research (short term) is closed in two ways. Firstly, by describing methods of market exploration that can be used earlier on in the process of development and diffusion of breakthrough technologies, so market research can be

  11. Exploring the Market for Breakthrough Technologies

    NARCIS (Netherlands)

    Ortt, J. Roland; Langley, David J.; Pals, Nico

    2007-01-01

    In this article, the gap between futures research (long term) and market research (short term) is closed in two ways. Firstly, by describing methods of market exploration that can be used earlier on in the process of development and diffusion of breakthrough technologies, so market research can be

  12. The Breakthrough Listen Search for Intelligent Life

    Science.gov (United States)

    Croft, Steve; Siemion, Andrew; De Boer, David; Enriquez, J. Emilio; Foster, Griffin; Gajjar, Vishal; Hellbourg, Greg; Hickish, Jack; Isaacson, Howard; Lebofsky, Matt; MacMahon, David; Price, Daniel; Werthimer, Dan

    2018-01-01

    The $100M, 10-year philanthropic "Breakthrough Listen" project is driving an unprecedented expansion of the search for intelligent life beyond Earth. Modern instruments allow ever larger regions of parameter space (luminosity function, duty cycle, beaming fraction, frequency coverage) to be explored, which is enabling us to place meaningful physical limits on the prevalence of transmitting civilizations. Data volumes are huge, and preclude long-term storage of the raw data products, so real-time and machine learning processing techniques must be employed to identify candidate signals as well as simultaneously classifying interfering sources. However, the Galaxy is now known to be a target-rich environment, teeming with habitable planets.Data from Breakthrough Listen can also be used by researchers in other areas of astronomy to study pulsars, fast radio bursts, and a range of other science targets. Breakthrough Listen is already underway in the optical and radio bands, and is also engaging with facilities across the world, including Square Kilometer Array precursors and pathfinders. I will give an overview of the technology, science goals, data products, and roadmap of Breakthrough Listen, as we attempt to answer one of humanity's oldest questions: Are we alone?

  13. The human body and weightlessness operational effects, problems and countermeasures

    CERN Document Server

    Thornton, William

    2017-01-01

    This book focuses on all of the major problems associated with the absence of body weight in space, by analyzing effects, adaption, and re-adaptation upon returning to Earth, using sound scientific principles embedded in a historical context. Serious problems for space travelers range from Space Motion Sickness (SMS) to recently discovered ocular effects that may permanently impair vision. Fluid loss and shifts, spinal changes, and bone and muscle loss are also all results of weightlessness. Starting with a brief definition and history of weightlessness, the authors then address in detail each problem as well as the countermeasures aimed at alleviating them. In some cases, alternative hypotheses regarding what can and should be attempted are also presented. As plans for long-term missions to the Moon and Mars develop, it will be essential to find countermeasures to weightlessness that are effective for missions that could span years.

  14. Evaluating Nanoparticle Breakthrough during Drinking Water Treatment

    Science.gov (United States)

    Chalew, Talia E. Abbott; Ajmani, Gaurav S.; Huang, Haiou

    2013-01-01

    Background: Use of engineered nanoparticles (NPs) in consumer products is resulting in NPs in drinking water sources. Subsequent NP breakthrough into treated drinking water is a potential exposure route and human health threat. Objectives: In this study we investigated the breakthrough of common NPs—silver (Ag), titanium dioxide (TiO2), and zinc oxide (ZnO)—into finished drinking water following conventional and advanced treatment. Methods: NPs were spiked into five experimental waters: groundwater, surface water, synthetic freshwater, synthetic freshwater containing natural organic matter, and tertiary wastewater effluent. Bench-scale coagulation/flocculation/sedimentation simulated conventional treatment, and microfiltration (MF) and ultrafiltration (UF) simulated advanced treatment. We monitored breakthrough of NPs into treated water by turbidity removal and inductively coupled plasma–mass spectrometry (ICP-MS). Results: Conventional treatment resulted in 2–20%, 3–8%, and 48–99% of Ag, TiO2, and ZnO NPs, respectively, or their dissolved ions remaining in finished water. Breakthrough following MF was 1–45% for Ag, 0–44% for TiO2, and 36–83% for ZnO. With UF, NP breakthrough was 0–2%, 0–4%, and 2–96% for Ag, TiO2, and ZnO, respectively. Variability was dependent on NP stability, with less breakthrough of aggregated NPs compared with stable NPs and dissolved NP ions. Conclusions: Although a majority of aggregated or stable NPs were removed by simulated conventional and advanced treatment, NP metals were detectable in finished water. As environmental NP concentrations increase, we need to consider NPs as emerging drinking water contaminants and determine appropriate drinking water treatment processes to fully remove NPs in order to reduce their potential harmful health outcomes. Citation: Abbott Chalew TE, Ajmani GS, Huang H, Schwab KJ. 2013. Evaluating nanoparticle breakthrough during drinking water treatment. Environ Health Perspect 121

  15. Functional Problems and Maintenance Operations of Hydraulic Turbines

    Directory of Open Access Journals (Sweden)

    Liliana Topliceanu

    2016-02-01

    Full Text Available The exploitation in good conditions of the hydroelectric power plant imposes a rigorous maintenance of equipment and operating facilities, primarily of the turbine. The efficiency of the turbine is strongly affected by any defects which could occur during the operation. The paper makes a synthesis of the most frequent failures which have occurred during the functioning of Kaplan turbines plant and the required maintenance plan that has to be adopted. The maintenance rules for the optimal working of these turbines are also emphasized.

  16. A Problem-Solving Approach to Teaching Operant Conditioning

    Science.gov (United States)

    Shields, Carolyn; Gredler, Margaret

    2003-01-01

    Psychology students frequently have misconceptions of basic concepts in operant conditioning. Prior classroom observations revealed that most students defined positive reinforcement as reward and equated negative reinforcement and punishment. Students also labeled positive reinforcement as rewarding good behavior and negative reinforcement as…

  17. On psichological problem of NPP operation and control

    International Nuclear Information System (INIS)

    Mashin, V.A.

    1994-01-01

    The role of psichological factor as a reserve for increasing NPP safety connected with human factor is discussed. It is emphasized that the process of NPP personnel professional training should not be restricted by formation of a certain set of knowledge, skills and experience. It is necessary to initiate ability for constant self-developing. Control for assurance of effective interaction of the whole NPP personnel is an important problem

  18. An Experiment on the Impact of Communication Problems in the Multi-cultural Operation of NPPs' Emergency Operation

    International Nuclear Information System (INIS)

    Kang, Seongkeun; Lee, Chanyoung; Seong, Poong Hyun; Ha, Jun Su

    2015-01-01

    Korean government won a contract of nuclear power plants to UAE government in 2010 and nuclear power plants are now under construction in Barakah, UAE. However, with technology transfer and international cooperation, there needs to consider several potential problems due to the differences between two culture of the countries such as language, technical culture and expectation. It is unknown how potential problems can lead to an unsafe plant operation as well. We got to know language problem is the main issue from analyzing the OERs. Korean nuclear power plant operators will work in UAE and they will operate the NPPs with other countries' operators and managers. Therefore they will have to use English when they communicate each other. The purpose of this paper is to confirm how much operators get stress and how much accuracy is declined when operators communicate together in English. Reducing human error is quite important to make nuclear power plants safety. As mental workload of human operator is increased, operators get more stress, then the probability of occurring human error may be increased. It will affect bad influence to nuclear power plants safety. There are many factors to make mental workload increased. We focused on communication problem which is a key factor of the increasing mental workload because many Korean operators will work in UAE nuclear power plants and they may work together with UAE operators. We designed experimental methods to be able to check this problem qualitatively and quantitatively. We analyzed four factors to find the communication problems from the experiments which are accuracy, efficiency, NASA-TLX, and brain wave. Accuracy, efficiency, brain wave are quantitative factors, and NASA-TLX is qualitative factor. To find the impact of how much English affects the operators' workload, we did two cases of experiments; one is experiment for diagnosis and the other is experiment for execution

  19. An Experiment on the Impact of Communication Problems in the Multi-cultural Operation of NPPs' Emergency Operation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Seongkeun; Lee, Chanyoung; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of); Ha, Jun Su [KUSTAR, Abu Dhabi (United Arab Emirates)

    2015-10-15

    Korean government won a contract of nuclear power plants to UAE government in 2010 and nuclear power plants are now under construction in Barakah, UAE. However, with technology transfer and international cooperation, there needs to consider several potential problems due to the differences between two culture of the countries such as language, technical culture and expectation. It is unknown how potential problems can lead to an unsafe plant operation as well. We got to know language problem is the main issue from analyzing the OERs. Korean nuclear power plant operators will work in UAE and they will operate the NPPs with other countries' operators and managers. Therefore they will have to use English when they communicate each other. The purpose of this paper is to confirm how much operators get stress and how much accuracy is declined when operators communicate together in English. Reducing human error is quite important to make nuclear power plants safety. As mental workload of human operator is increased, operators get more stress, then the probability of occurring human error may be increased. It will affect bad influence to nuclear power plants safety. There are many factors to make mental workload increased. We focused on communication problem which is a key factor of the increasing mental workload because many Korean operators will work in UAE nuclear power plants and they may work together with UAE operators. We designed experimental methods to be able to check this problem qualitatively and quantitatively. We analyzed four factors to find the communication problems from the experiments which are accuracy, efficiency, NASA-TLX, and brain wave. Accuracy, efficiency, brain wave are quantitative factors, and NASA-TLX is qualitative factor. To find the impact of how much English affects the operators' workload, we did two cases of experiments; one is experiment for diagnosis and the other is experiment for execution.

  20. Some problems in operator theory on bounded symmetric domains

    Czech Academy of Sciences Publication Activity Database

    Engliš, Miroslav

    2004-01-01

    Roč. 81, č. 1 (2004), s. 51-71 ISSN 0167-8019. [Representations of Lie groups, harmonic analysis on homogeneous spaces and quantization. Leiden, 07.12.2002-13.12.2002] R&D Projects: GA ČR GA201/03/0041 Institutional research plan: CEZ:AV0Z1019905 Keywords : homogeneous multiplication operators * bounded symmetric domains Subject RIV: BA - General Mathematics Impact factor: 0.354, year: 2004

  1. The management of breakthrough cancer pain--educational needs a European nursing survey.

    Science.gov (United States)

    Wengström, Y; Rundström, C; Geerling, J; Pappa, T; Weisse, I; Williams, S C; Zavratnik, B; Rustøen, T

    2014-01-01

    Poorly managed cancer pain is well known to profoundly impact the patient's daily life and interfere with quality of life. Nurses who cared for patients with cancer from 12 European countries participated in a survey of breakthrough cancer pain practice. The purpose was to investigate how nurses assess breakthrough cancer pain, use of standardised tools, confidence in supporting patients and awareness of medications. Responses from 1241 participants showed country variations. The majority of the sample was female, Germany had the highest proportion of male nurses (21.0%), followed by Greece (15.8%). A significantly larger proportion of nurses with longer experience and more education (78.8%) used a comprehensive definition of breakthrough cancer pain. Significant variations in training were found; 71% of Finnish nurses had received training compared with 6% of Greek nurses. Training and using a standardised assessment tool was associated with a significant increase in the nurses' perceived ability to distinguish between breakthrough and background pain. Nurses in countries with the highest proportion of training were most confident in supporting patients. In conclusion, there still exists problems with effective management of patients' breakthrough cancer pain, continuing inability to define the difference between background and breakthrough cancer pain leads to poor treatment. © 2013 John Wiley & Sons Ltd.

  2. Automatic Combination of Operators in a Genetic Algorithm to Solve the Traveling Salesman Problem.

    Directory of Open Access Journals (Sweden)

    Carlos Contreras-Bolton

    Full Text Available Genetic algorithms are powerful search methods inspired by Darwinian evolution. To date, they have been applied to the solution of many optimization problems because of the easy use of their properties and their robustness in finding good solutions to difficult problems. The good operation of genetic algorithms is due in part to its two main variation operators, namely, crossover and mutation operators. Typically, in the literature, we find the use of a single crossover and mutation operator. However, there are studies that have shown that using multi-operators produces synergy and that the operators are mutually complementary. Using multi-operators is not a simple task because which operators to use and how to combine them must be determined, which in itself is an optimization problem. In this paper, it is proposed that the task of exploring the different combinations of the crossover and mutation operators can be carried out by evolutionary computing. The crossover and mutation operators used are those typically used for solving the traveling salesman problem. The process of searching for good combinations was effective, yielding appropriate and synergic combinations of the crossover and mutation operators. The numerical results show that the use of the combination of operators obtained by evolutionary computing is better than the use of a single operator and the use of multi-operators combined in the standard way. The results were also better than those of the last operators reported in the literature.

  3. Current problems of VVER-1000 reactor core operation in Ukraine

    International Nuclear Information System (INIS)

    Bykov, A.

    2000-01-01

    Planned control rod drop time registration was passed two times a year per reactor unit. In 1992-1993 some control rods at almost all WWER-1000 units exceed the prescribed 4 second time limit. More than 7000 individual control rod time tests were made from the main correction measures. The following conclusions have been made from the current statistics data: (a) The main role of the vibration factor is proven in the fuel assembly (FA) bowing process. The greatest drop times and maximum of bowing values are concentrated at the vibration zone (2-4 FA rows from the reactor partition). The first FA row seems to be stable due to the interaction with the reactor partition; (b) Bowing relaxation will proceed during several fuel cycles (estimated value is 4-6), and depends on previous FA use history. It seems to be proven that previously bowed FAs effect the new FA, so previously bowed FAs are straightened until the middle of the fuel cycle. At some reactor units small drop time reduction is observed up to half of the fuel cycle from the start time values; (c) Control rod drop medium time (t) has almost linear dependence on operation time (τ) (t=k x τ + b]. Estimated by the method of least squares, values of k and b differ from unit to unit and from cycle to cycle. Values of k and b are in following ranges: b=2.0 - 2.6 seconds, k=5-50x10 -4 seconds per effective operation day; (d) Control rod drop time distribution changes through operation time. The position of maximum starts to shift after 240 effective days, and the form of the distribution start to change at the same time. Before 240 effective days, the distribution essentially does not change. To guarantee that the control rod system reliability is now within prescribed limits, we should continue testing. Additional analysis is needed. Test frequency can be reduced to avoid additional unreasonable transients. (authors)

  4. Damped oscillatory integrals and boundedness problem for maximal operators

    International Nuclear Information System (INIS)

    Ikromov, Isroil A.

    2003-06-01

    We consider a real-analytic hypersurface S in IR n+1 with surface measure dσ, ψ is a compactly supported non-negative smooth cut-off function, and we let dμ q be the surface measure with dμ q ψvertical barΛ(X)vertical bar q dσ, where Λ(X) is a damping factor defined by the matrix of a second fundamental form of the surface. We show that if S is a real analytic hypersurface, then μ-circumflex q (ξ) decays as O(vertical barξvertical bar -(1/2+ε) ), where ε > 0, provided q > 3/2. We also consider applications involving maximal operators associated to averages of functions over hypersurfaces. (author)

  5. Identification of Error Types in Preservice Teachers' Attempts to Create Fraction Story Problems for Specified Operations

    Science.gov (United States)

    McAllister, Cheryl J.; Beaver, Cheryl

    2012-01-01

    The purpose of this research was to determine if recognizable error types exist in the work of preservice teachers required to create story problems for specific fraction operations. Students were given a particular single-operation fraction expression and asked to do the calculation and then create a story problem that would require the use of…

  6. A Breakthrough for Strengthening Tusi Studies

    Institute of Scientific and Technical Information of China (English)

    Li Liangpin; Peng Furong

    2016-01-01

    Following the inscription of China’s Tusi ( native officials ) relics onto the list of world cultural heritage in 2015 , Tusi studies has already become a current topic. However, if we ignored the numerous and complicated historical events, the tremendous amount of historical materials and cases with different characteristics, it is difficult to realize a theoretical breakthrough and academic in-novation. Hence, if the academic world intends to find a new breakthrough in Tusi studies, enough attention should be given to the analysis of past e-vents, digging out historical materials, and case studies—only by which can Tusi studies be strengthened. 1 . Analysis of past events Scholarly research of the Tusi in the past has paid more attention to the system, culture ,and ap-plication of Tusi relics for inscription onto the list of world cultural heritage, but has ignored analysis of significant events. Due to the influence of the political right, economic benefit, and cultural in-filtration, there had always been competition be-tween the central government and the Tusi regime during the Yuan, Ming and Qing dynasties. When some conflicts could not be resolved through nego-tiation, large-scale events or battles were the re-sult. Judging from current studies on every small or large battle between the central government and a Tusi regime, we can see that scholars always focus their studies on the background, process, result, historical influence and related evaluations. Up to now, no scholars have written a monograph of these big events closely related to the Tusi, which is doubtlessly a pity when it comes to Tusi studies. We think that three issues should be noticed while analyzing big events related to the Tusi:1 ) taking the overall situation into consideration; 2 ) having theoretical sight; and 3 ) having a theoretical awareness. 2 . Uncovering historical materials The historical materials are especially impor-tant for the study of the Tusi system or Tusi issues

  7. Breakthrough Propulsion Physics Project: Project Management Methods

    Science.gov (United States)

    Millis, Marc G.

    2004-01-01

    To leap past the limitations of existing propulsion, the NASA Breakthrough Propulsion Physics (BPP) Project seeks further advancements in physics from which new propulsion methods can eventually be derived. Three visionary breakthroughs are sought: (1) propulsion that requires no propellant, (2) propulsion that circumvents existing speed limits, and (3) breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis is to identify credible research that will make measurable progress toward these goals in the near-term. The management techniques to address this challenge are presented, with a special emphasis on the process used to review, prioritize, and select research tasks. This selection process includes these key features: (a) research tasks are constrained to only address the immediate unknowns, curious effects or critical issues, (b) reliability of assertions is more important than the implications of the assertions, which includes the practice where the reviewers judge credibility rather than feasibility, and (c) total scores are obtained by multiplying the criteria scores rather than by adding. Lessons learned and revisions planned are discussed.

  8. Recursive-operator method in vibration problems for rod systems

    Science.gov (United States)

    Rozhkova, E. V.

    2009-12-01

    Using linear differential equations with constant coefficients describing one-dimensional dynamical processes as an example, we show that the solutions of these equations and systems are related to the solution of the corresponding numerical recursion relations and one does not have to compute the roots of the corresponding characteristic equations. The arbitrary functions occurring in the general solution of the homogeneous equations are determined by the initial and boundary conditions or are chosen from various classes of analytic functions. The solutions of the inhomogeneous equations are constructed in the form of integro-differential series acting on the right-hand side of the equation, and the coefficients of the series are determined from the same recursion relations. The convergence of formal solutions as series of a more general recursive-operator construction was proved in [1]. In the special case where the solutions of the equation can be represented in separated variables, the power series can be effectively summed, i.e., expressed in terms of elementary functions, and coincide with the known solutions. In this case, to determine the natural vibration frequencies, one obtains algebraic rather than transcendental equations, which permits exactly determining the imaginary and complex roots of these equations without using the graphic method [2, pp. 448-449]. The correctness of the obtained formulas (differentiation formulas, explicit expressions for the series coefficients, etc.) can be verified directly by appropriate substitutions; therefore, we do not prove them here.

  9. On a non classical oblique derivative problem for parabolic singular integro-differential operators

    International Nuclear Information System (INIS)

    Nguyen Minh Chuong; Le Quang Trung

    1989-10-01

    In this paper an oblique derivative problem for parabolic singular integro-differential operators was studied. In this problem the direction of the derivative may be tangent to the boundary of the domain. By the large parameter method theorems of existence and uniqueness of solutions of the problem were obtained. (author). 10 refs

  10. On the article of V. A. Mashin 'Computerized systems of NPP operators support. (Psychological problems)'

    International Nuclear Information System (INIS)

    Prushinskij, B.Ya.

    1995-01-01

    Basic aspects of V.A. Mashin's article on NPP operator support computerized systems and problems of man-machine interrelation are analyzed. Sharing in the significant degree Mashin's point of view the author of this article considers that the most important aspects of this problem consist in dividing the responsibility for NPP safe operation between all participants of the NPP creation and operation and in the area of practical experience in assuring control functions reliability

  11. An inverse boundary value problem for the Schroedinger operator with vector potentials in two dimensions

    International Nuclear Information System (INIS)

    Ziqi Sun

    1993-01-01

    During the past few years a considerable interest has been focused on the inverse boundary value problem for the Schroedinger operator with a scalar (electric) potential. The popularity gained by this subject seems to be due to its connection with the inverse scattering problem at fixed energy, the inverse conductivity problem and other important inverse problems. This paper deals with an inverse boundary value problem for the Schroedinger operator with vector (electric and magnetic) potentials. As in the case of the scalar potential, results of this study would have immediate consequences in the inverse scattering problem for magnetic field at fixed energy. On the other hand, inverse boundary value problems for elliptic operators are of independent interest. The study is partly devoted to the understanding of the inverse boundary value problem for a class of general elliptic operator of second order. Note that a self-adjoint elliptic operator of second order with Δ as its principal symbol can always be written as a Schroedinger operator with vector potentials

  12. Computer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux.

    Science.gov (United States)

    Arlen, Angela M; Alexander, Siobhan E; Wald, Moshe; Cooper, Christopher S

    2016-10-01

    Factors influencing the decision to surgically correct vesicoureteral reflux (VUR) include risk of breakthrough febrile urinary tract infection (fUTI) or renal scarring, and decreased likelihood of spontaneous resolution. Improved identification of children at risk for recurrent fUTI may impact management decisions, and allow for more individualized VUR management. We have developed and investigated the accuracy of a multivariable computational model to predict probability of breakthrough fUTI in children with primary VUR. Children with primary VUR and detailed clinical and voiding cystourethrogram (VCUG) data were identified. Patient demographics, VCUG findings including grade, laterality, and bladder volume at onset of VUR, UTI history, presence of bladder-bowel dysfunction (BBD), and breakthrough fUTI were assessed. The VCUG dataset was randomized into a training set of 288 with a separate representational cross-validation set of 96. Various model types and architectures were investigated using neUROn++, a set of C++ programs. Two hundred fifty-five children (208 girls, 47 boys) diagnosed with primary VUR at a mean age of 3.1 years (±2.6) met all inclusion criteria. A total 384 VCUGs were analyzed. Median follow-up was 24 months (interquartile range 12-52 months). Sixty-eight children (26.7%) experienced 90 breakthrough fUTI events. Dilating VUR, reflux occurring at low bladder volumes, BBD, and history of multiple infections/fUTI were associated with breakthrough fUTI (Table). A 2-hidden node neural network model had the best fit with a receiver operating characteristic curve area of 0.755 for predicting breakthrough fUTI. The risk of recurrent febrile infections, renal parenchymal scarring, and likelihood of spontaneous resolution, as well as parental preference all influence management of primary VUR. The genesis of UTI is multifactorial, making precise prediction of an individual child's risk of breakthrough fUTI challenging. Demonstrated risk factors for

  13. Numerical Solution of Time-Dependent Problems with a Fractional-Power Elliptic Operator

    Science.gov (United States)

    Vabishchevich, P. N.

    2018-03-01

    A time-dependent problem in a bounded domain for a fractional diffusion equation is considered. The first-order evolution equation involves a fractional-power second-order elliptic operator with Robin boundary conditions. A finite-element spatial approximation with an additive approximation of the operator of the problem is used. The time approximation is based on a vector scheme. The transition to a new time level is ensured by solving a sequence of standard elliptic boundary value problems. Numerical results obtained for a two-dimensional model problem are presented.

  14. Breakthrough at NIF 'unlikely' in 2010

    Science.gov (United States)

    Harris, Margaret

    2010-05-01

    Hopes of reaching a milestone in fusion research by the end of 2010 have dimmed following a US government report that plays down the chances of an early breakthrough and sharply criticizes management of the 4bn National Ignition Facility (NIF). In the report, officials from the Government Accountability Office (GAO) state that ignition - fusion's "break-even" point - is "unlikely" to occur at the laser-fusion lab this year and that "significant scientific and technical challenges" could delay or even prevent the facility from achieving ignition by 2012.

  15. Predicting the Risk of Breakthrough Urinary Tract Infections: Primary Vesicoureteral Reflux.

    Science.gov (United States)

    Hidas, Guy; Billimek, John; Nam, Alexander; Soltani, Tandis; Kelly, Maryellen S; Selby, Blake; Dorgalli, Crystal; Wehbi, Elias; McAleer, Irene; McLorie, Gordon; Greenfield, Sheldon; Kaplan, Sherrie H; Khoury, Antoine E

    2015-11-01

    We constructed a risk prediction instrument stratifying patients with primary vesicoureteral reflux into groups according to their 2-year probability of breakthrough urinary tract infection. Demographic and clinical information was retrospectively collected in children diagnosed with primary vesicoureteral reflux and followed for 2 years. Bivariate and binary logistic regression analyses were performed to identify factors associated with breakthrough urinary tract infection. The final regression model was used to compute an estimation of the 2-year probability of breakthrough urinary tract infection for each subject. Accuracy of the binary classifier for breakthrough urinary tract infection was evaluated using receiver operator curve analysis. Three distinct risk groups were identified. The model was then validated in a prospective cohort. A total of 252 bivariate analyses showed that high grade (IV or V) vesicoureteral reflux (OR 9.4, 95% CI 3.8-23.5, p urinary tract infection (OR 5.3, 95% CI 1.1-24.7, p = 0.034) and female gender (OR 2.6, 95% CI 0.097-7.11, p urinary tract infection. Subgroup analysis revealed bladder and bowel dysfunction was a significant risk factor more pronounced in low grade (I to III) vesicoureteral reflux (OR 2.8, p = 0.018). The estimation model was applied for prospective validation, which demonstrated predicted vs actual 2-year breakthrough urinary tract infection rates of 19% vs 21%. Stratifying the patients into 3 risk groups based on parameters in the risk model showed 2-year risk for breakthrough urinary tract infection was 8.6%, 26.0% and 62.5% in the low, intermediate and high risk groups, respectively. This proposed risk stratification and probability model allows prediction of 2-year risk of patient breakthrough urinary tract infection to better inform parents of possible outcomes and treatment strategies. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights

  16. Gene therapy, early promises, subsequent problems, and recent breakthroughs.

    Science.gov (United States)

    Razi Soofiyani, Saeideh; Baradaran, Behzad; Lotfipour, Farzaneh; Kazemi, Tohid; Mohammadnejad, Leila

    2013-01-01

    Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist's ability to manipulate genetic material via recombinant DNA technology made this purpose to reality. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. While gene therapy initially conceived as a way to treat life-threatening disorders (inborn errors, cancers) refractory to conventional treatment, to date gene therapy is considered for many non-life-threatening conditions including those adversely influence on a patient's quality of life. Gene therapy has made significant progress, including tangible success, although much slower than was initially predicted. Although, gene therapies still at a fairly primitive stage, it is firmly science based. There is justifiable hope that with enhanced pathobiological understanding and biotechnological improvements, gene therapy will be a standard part of clinical practice within 20 years.

  17. Gene Therapy, Early Promises, Subsequent Problems, and Recent Breakthroughs

    Directory of Open Access Journals (Sweden)

    Saeideh Razi Soofiyani

    2013-08-01

    Full Text Available Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist’s ability to manipulate genetic material via recombinant DNA technology made this purpose to reality. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. While gene therapy initially conceived as a way to treat life-threatening disorders (inborn errors, cancers refractory to conventional treatment, to date gene therapy is considered for many non–life-threatening conditions including those adversely influence on a patient’s quality of life. Gene therapy has made significant progress, including tangible success, although much slower than was initially predicted. Although, gene therapies still at a fairly primitive stage, it is firmly science based. There is justifiable hope that with enhanced pathobiological understanding and biotechnological improvements, gene therapy will be a standard part of clinical practice within 20 years.

  18. Generalized ladder operators for the Dirac-Coulomb problem via SUSY QM

    International Nuclear Information System (INIS)

    Rodrigues, R. de Lima; Universidade Federal de Campina Grande, PB

    2003-12-01

    The supersymmetry in quantum mechanics and shape invariance condition are applied as an algebraic method to solving the Dirac-Coulomb problem. The ground state and the excited states are investigated via new generalized ladder operators. (author)

  19. An abstract approach to some spectral problems of direct sum differential operators

    Directory of Open Access Journals (Sweden)

    Maksim S. Sokolov

    2003-07-01

    Full Text Available In this paper, we study the common spectral properties of abstract self-adjoint direct sum operators, considered in a direct sum Hilbert space. Applications of such operators arise in the modelling of processes of multi-particle quantum mechanics, quantum field theory and, specifically, in multi-interval boundary problems of differential equations. We show that a direct sum operator does not depend in a straightforward manner on the separate operators involved. That is, on having a set of self-adjoint operators giving a direct sum operator, we show how the spectral representation for this operator depends on the spectral representations for the individual operators (the coordinate operators involved in forming this sum operator. In particular it is shown that this problem is not immediately solved by taking a direct sum of the spectral properties of the coordinate operators. Primarily, these results are to be applied to operators generated by a multi-interval quasi-differential system studied, in the earlier works of Ashurov, Everitt, Gesztezy, Kirsch, Markus and Zettl. The abstract approach in this paper indicates the need for further development of spectral theory for direct sum differential operators.

  20. Some particular problems put by operating experimental reactors; Quelques problemes particuliers poses par le fonctionnement des piles laboratoires

    Energy Technology Data Exchange (ETDEWEB)

    Candiotti, C; Mabeix, R; Uguen, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [French] Les redacteurs se basant sur six annees d'experience dans l'exploitation de reacteurs de recherche, exposent tout d'abord les differences d'utilisation entre ces engins et d'autres appareils fonctionnellement similaires et font ressortir, par voie de consequence, les servitudes correspondantes. Ces servitudes posent des problemes tres particuliers dans les domaines de l'exploitation proprement dite, de l'entretien, des modifications ou adjonctions apportees a l'ensemble. (auteur)

  1. Some particular problems put by operating experimental reactors; Quelques problemes particuliers poses par le fonctionnement des piles laboratoires

    Energy Technology Data Exchange (ETDEWEB)

    Candiotti, C.; Mabeix, R.; Uguen, R. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    On basis of a six years experience in operating research reactors, the authors explain, first, the difference in their utilization between these piles and another similar ones and, after, in consequence, they set off corresponding servitudes. These servitudes put very particular problems in operating itself, maintenance, modifications or additions on these apparatus. (author) [French] Les redacteurs se basant sur six annees d'experience dans l'exploitation de reacteurs de recherche, exposent tout d'abord les differences d'utilisation entre ces engins et d'autres appareils fonctionnellement similaires et font ressortir, par voie de consequence, les servitudes correspondantes. Ces servitudes posent des problemes tres particuliers dans les domaines de l'exploitation proprement dite, de l'entretien, des modifications ou adjonctions apportees a l'ensemble. (auteur)

  2. A Riemann-Hilbert approach to the inverse problem for the Stark operator on the line

    Science.gov (United States)

    Its, A.; Sukhanov, V.

    2016-05-01

    The paper is concerned with the inverse scattering problem for the Stark operator on the line with a potential from the Schwartz class. In our study of the inverse problem, we use the Riemann-Hilbert formalism. This allows us to overcome the principal technical difficulties which arise in the more traditional approaches based on the Gel’fand-Levitan-Marchenko equations, and indeed solve the problem. We also produce a complete description of the relevant scattering data (which have not been obtained in the previous works on the Stark operator) and establish the bijection between the Schwartz class potentials and the scattering data.

  3. Is a Breakthrough on Climate Change Governance on the Horizon?

    DEFF Research Database (Denmark)

    Figueroa, Maria Josefina

    The recently released Fifth Assessment report of the IPCC has highlighted again with unprecedented scope and insight the urgency of addressing climate change. The international community has pledged to devise the next international agreement on climate change by 2015, while the EU and in particular...... the Scandinavian countries have forged ahead advancing a variety of policies to respond to climate change. Similarly, regions, municipalities, and private actors across the world are also contributing to climate governance. This paper asks whether the world is reaching a tipping point where a breakthrough...... on climate change governance is near?. The answer is approached by contrasting the governance model within which the IPCC operates and the conditions of policy and governance interaction toward the more scientific foundations laid out by IPCC, with the range of multilateral climate governance...

  4. Genetic Algorithm for Traveling Salesman Problem with Modified Cycle Crossover Operator

    Directory of Open Access Journals (Sweden)

    Abid Hussain

    2017-01-01

    Full Text Available Genetic algorithms are evolutionary techniques used for optimization purposes according to survival of the fittest idea. These methods do not ensure optimal solutions; however, they give good approximation usually in time. The genetic algorithms are useful for NP-hard problems, especially the traveling salesman problem. The genetic algorithm depends on selection criteria, crossover, and mutation operators. To tackle the traveling salesman problem using genetic algorithms, there are various representations such as binary, path, adjacency, ordinal, and matrix representations. In this article, we propose a new crossover operator for traveling salesman problem to minimize the total distance. This approach has been linked with path representation, which is the most natural way to represent a legal tour. Computational results are also reported with some traditional path representation methods like partially mapped and order crossovers along with new cycle crossover operator for some benchmark TSPLIB instances and found improvements.

  5. Analysis of Pending Problems for a Technology Demand of Domestic Operational Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Dae Seo; Park, Won Seok; Wi, Myung Hwan; Ha, Jae Joo

    2008-01-15

    Eleven technology fields were chosen, which have a relation with the solution of the pending problems of domestic operational nuclear power plants to manage an efficient operation and safe regulation for domestic nuclear power plants. The progressive background, requirements, and performance on the pending problems, 34, of an operation and regulation for domestic nuclear power plants were analyzed with regard to a risk information application, severe accident, PSR of structural materials, underwater monitoring, operation inspection and a fire protection, an instrument aging, metal integrity and steam generator, human technology and a digital I and C, quality assurance, secondary system and a user reliance and mass communications. KAERI's role is to provide a solution to these pending problems of domestic nuclear power plants. KAERI's technology is to be applicable to the pending problems for domestic nuclear power plants to raise an operational efficiency and an application frequency of nuclear power plants. In the future, a technology treaty between KAERI and KHNP is to be established to solve the pending problems for domestic nuclear power plants. Operation rate of nuclear power plants will also be raised and contribute to the supply of national energy due to this technology treaty.

  6. 75 Breakthroughs by the U.S. Department of Energy's National Laboratories; Breakthroughs 2017

    Energy Technology Data Exchange (ETDEWEB)

    None

    2017-01-01

    Born at a time when the world faced a dire threat, the National Laboratory System protects America through science and technology. For more than 75 years, the Department of Energy’s national laboratories have solved important problems in science, energy and national security. Partnering with industry and academia, the laboratories also drive innovation to advance economic competitiveness and ensure our nation’s future prosperity. Over the years, America's National Laboratories have been changing and improving the lives of millions of people and this expertise continues to keep our nation at the forefront of science and technology in a rapidly changing world. This network of Department of Energy Laboratories has grown into 17 facilities across the country. As this list of breakthroughs attests, Laboratory discoveries have spawned industries, saved lives, generated new products, fired the imagination and helped to reveal the secrets of the universe.

  7. 50 Breakthroughs by America's National Labs

    Science.gov (United States)

    2011-01-01

    America's National Laboratory system has been changing and improving the lives of millions for more than 80 years. Born at a time of great societal need, this network of Department of Energy Laboratories has now grown into 17 facilities, working together as engines of prosperity and invention. As this list of 50 Breakthroughs attests, National Laboratory discoveries have spawned industries, saved lives, generated new products, fired the imagination, and helped to reveal the secrets of the universe. Rooted in the need to be the best and bring the best, America's National Laboratories have put an American stamp on the past century of science. With equal ingenuity and tenacity, they are now engaged in winning the future.

  8. Breakthroughs in neuroactive steroid drug discovery.

    Science.gov (United States)

    Blanco, Maria-Jesus; La, Daniel; Coughlin, Quinn; Newman, Caitlin A; Griffin, Andrew M; Harrison, Boyd L; Salituro, Francesco G

    2018-01-15

    Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABA A ) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS), and there is growing evidence suggesting that dysregulation of neurosteroid production plays a role in numerous neurological disorders. The significant unmet medical need for treatment of CNS disorders has increased the interest for these types of compounds. In this review, we highlight recent progress in the clinical development of NAS drug candidates, in addition to preclinical breakthroughs in the identification of novel NASs, mainly for GABA A and NMDA receptor modulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Controlled Nucleosynthesis Breakthroughs in Experiment and Theory

    CERN Document Server

    Adamenko, Stanislav; Merwe, Alwyn

    2007-01-01

    This book ushers in a new era of experimental and theoretical investigations into collective processes, structure formation, and self-organization of nuclear matter. It reports the results of experiments wherein for the first time the nuclei constituting our world (those displayed in Mendeleev's table as well as the super-heavy ones) have been artificially created. Pioneering breakthroughs are described, achieved at the "Proton-21" Laboratory, Kiev, Ukraine, in a variety of new physical and technological directions. A detailed description of the main experiments, their analyses, and the interpretation of copious experimental data are given, along with the methodology governing key measurements and the processing algorithms of the data that empirically confirm the occurrence of macroscopic self-organizing processes leading to the nuclear transformations of various materials. The basic concepts underlying the initiation of self-sustaining collective processes that result in the formation of nuclear structures a...

  10. Experiments on the Impact of language Problems in the Multi-cultural Operation of NPPs' Emergency Operation

    International Nuclear Information System (INIS)

    Kang, Seongkeun; Kim, Taehoon; Seong, Poong Hyun; Ha, Jun Su

    2016-01-01

    In 2010, The Korea Electric Power Corporation (KEPCO) was awarded a multi-billion dollar bid to construct the first nuclear power plant in Barakah, UAE. One must keep in mind however, that with technology transfer and international cooperation comes a host of potential problems arising from cultural differences such as language, everyday habitudes and workplace expectation. As of now, how problematic these potential issues may become is unknown. Of the aforementioned factors, communication is perhaps of foremost importance. We investigated UAE culture-related issues through analysis of operating experience reviews (OERs) and came to the conclusion that the language barrier needed utmost attention. Korean nuclear power plant operators will work in UAE and will operate the NPPs with operators and managers of other nationalities as well. The purpose of this paper is firstly to confirm that operators are put under mental stress, and secondly to demonstrate the decline in accuracy when they must work in English. Reducing human error is quite important to make nuclear power plants safer. As the mental workload of human operator is increased, the probability of a human error occurring also increases. It will have a negative influence on the plant’s safety. There are many factors which can potentially increase mental workload. We focused on communication problem which is a key factor of increasing mental workload because many Korean operators will work in UAE nuclear power plants and may work together with UAE operators. From these experiments we compared how performance of both Korean and UAE subjects were decreased when they use English. We designed experimental methods to be able to check this problem qualitatively and quantitatively. We analyzed four factors to find the communication problems from the experiments which are accuracy, efficiency, NASA-TLX, and brain wave. Accuracy, efficiency, brain wave are quantitative factors, and NASA-TLX is qualitative factor. To

  11. Experiments on the Impact of language Problems in the Multi-cultural Operation of NPPs' Emergency Operation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Seongkeun; Kim, Taehoon; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of); Ha, Jun Su [KUSTAR, Abu Dhabi (United Arab Emirates)

    2016-10-15

    In 2010, The Korea Electric Power Corporation (KEPCO) was awarded a multi-billion dollar bid to construct the first nuclear power plant in Barakah, UAE. One must keep in mind however, that with technology transfer and international cooperation comes a host of potential problems arising from cultural differences such as language, everyday habitudes and workplace expectation. As of now, how problematic these potential issues may become is unknown. Of the aforementioned factors, communication is perhaps of foremost importance. We investigated UAE culture-related issues through analysis of operating experience reviews (OERs) and came to the conclusion that the language barrier needed utmost attention. Korean nuclear power plant operators will work in UAE and will operate the NPPs with operators and managers of other nationalities as well. The purpose of this paper is firstly to confirm that operators are put under mental stress, and secondly to demonstrate the decline in accuracy when they must work in English. Reducing human error is quite important to make nuclear power plants safer. As the mental workload of human operator is increased, the probability of a human error occurring also increases. It will have a negative influence on the plant’s safety. There are many factors which can potentially increase mental workload. We focused on communication problem which is a key factor of increasing mental workload because many Korean operators will work in UAE nuclear power plants and may work together with UAE operators. From these experiments we compared how performance of both Korean and UAE subjects were decreased when they use English. We designed experimental methods to be able to check this problem qualitatively and quantitatively. We analyzed four factors to find the communication problems from the experiments which are accuracy, efficiency, NASA-TLX, and brain wave. Accuracy, efficiency, brain wave are quantitative factors, and NASA-TLX is qualitative factor. To

  12. Evaluation of nuclear power plant operating procedures classifications and interfaces: Problems and techniques for improvement

    International Nuclear Information System (INIS)

    Barnes, V.E.; Radford, L.R.

    1987-02-01

    This report presents activities and findings of a project designed to evaluate current practices and problems related to procedure classification schemes and procedure interfaces in commercial nuclear power plants. The phrase ''procedure classification scheme'' refers to how plant operating procedures are categorized and indexed (e.g., normal, abnormal, emergency operating procedures). The term ''procedure interface'' refers to how reactor operators are instructed to transition within and between procedures. The project consisted of four key tasks, including (1) a survey of literature regarding problems associated with procedure classifications and interfaces, as well as techniques for overcoming them; (2) interviews with experts in the nuclear industry to discuss the appropriate scope of different classes of operating procedures and techniques for managing interfaces between them; (3) a reanalysis of data gathered about nuclear power plant normal operating and off-normal operating procedures in a related project, ''Program Plan for Assessing and Upgrading Operating Procedures for Nuclear Power Plants''; and (4) solicitation of the comments and expert opinions of a peer review group on the draft project report and on proposed techniques for resolving classification and interface issues. In addition to describing these activities and their results, recommendations for NRC and utility actions to address procedure classification and interface problems are offered

  13. A GPU Implementation of Local Search Operators for Symmetric Travelling Salesman Problem

    Directory of Open Access Journals (Sweden)

    Juraj Fosin

    2013-06-01

    Full Text Available The Travelling Salesman Problem (TSP is one of the most studied combinatorial optimization problem which is significant in many practical applications in transportation problems. The TSP problem is NP-hard problem and requires large computation power to be solved by the exact algorithms. In the past few years, fast development of general-purpose Graphics Processing Units (GPUs has brought huge improvement in decreasing the applications’ execution time. In this paper, we implement 2-opt and 3-opt local search operators for solving the TSP on the GPU using CUDA. The novelty presented in this paper is a new parallel iterated local search approach with 2-opt and 3-opt operators for symmetric TSP, optimized for the execution on GPUs. With our implementation large TSP problems (up to 85,900 cities can be solved using the GPU. We will show that our GPU implementation can be up to 20x faster without losing quality for all TSPlib problems as well as for our CRO TSP problem.

  14. ABOLISHING AND ESTABLISHING OPERATION ANALYSES OF SOCIAL ATTENTION AS POSITIVE REINFORCEMENT FOR PROBLEM BEHAVIOR

    OpenAIRE

    McGinnis, Molly A; Houchins-Juárez, Nealetta; McDaniel, Jill L; Kennedy, Craig H

    2010-01-01

    Three participants whose problem behavior was maintained by contingent attention were exposed to 45-min presessions in which attention was withheld, provided on a fixed-time (FT) 15-s schedule, or provided on an FT 120-s schedule. Following each presession, participants were then tested in a 15-min session similar to the social attention condition of an analogue functional analysis. The results showed establishing operation conditions increased problem behavior during tests and that abolishin...

  15. A hybrid heuristic algorithm for the open-pit-mining operational planning problem.

    OpenAIRE

    Souza, Marcone Jamilson Freitas; Coelho, Igor Machado; Ribas, Sabir; Santos, Haroldo Gambini; Merschmann, Luiz Henrique de Campos

    2010-01-01

    This paper deals with the Open-Pit-Mining Operational Planning problem with dynamic truck allocation. The objective is to optimize mineral extraction in the mines by minimizing the number of mining trucks used to meet production goals and quality requirements. According to the literature, this problem is NPhard, so a heuristic strategy is justified. We present a hybrid algorithm that combines characteristics of two metaheuristics: Greedy Randomized Adaptive Search Procedures and General Varia...

  16. The motivating operation and negatively reinforced problem behavior: a systematic review.

    Science.gov (United States)

    Langthorne, Paul; McGill, Peter; Oliver, Chris

    2014-01-01

    The concept of motivational operations exerts an increasing influence on the understanding and assessment of problem behavior in people with intellectual and developmental disability. In this systematic review of 59 methodologically robust studies of the influence of motivational operations in negative reinforcement paradigms in this population, we identify themes related to situational and biological variables that have implications for assessment, intervention, and further research. There is now good evidence that motivational operations of differing origins influence negatively reinforced problem behavior, and that these might be subject to manipulation to facilitate favorable outcomes. There is also good evidence that some biological variables warrant consideration in assessment procedures as they predispose the person's behavior to be influenced by specific motivational operations. The implications for assessment and intervention are made explicit with reference to variables that are open to manipulation or that require further research and conceptualization within causal models.

  17. Breakdown Breakthrough: NREL Finds Easier Ways to Deconstruct Biomass |

    Science.gov (United States)

    News | NREL Breakdown Breakthrough: NREL Finds Easier Ways to Deconstruct Biomass Breakdown Breakthrough: NREL Finds Easier Ways to Deconstruct Biomass May 22, 2018 Roman Brunecky (left), Yannick Bomble soften biomass. Photo by Dennis Schroeder, NREL If there's an easier, more efficient method, science will

  18. Process pump operating problems and equipment failures, F-Canyon Reprocessing Facility, Savannah River Plant

    International Nuclear Information System (INIS)

    Durant, W.S.; Starks, J.B.; Galloway, W.D.

    1987-02-01

    A compilation of operating problems and equipment failures associated with the process pumps in the Savannah River Plant F-Canyon Fuel Reprocessing Facility is presented. These data have been collected over the 30-year operation of the facility. An analysis of the failure rates of the pumps is also presented. A brief description of the pumps and the data bank from which the information was sorted is also included

  19. A knowledge acquisition process to analyse operational problems in solid waste management facilities.

    Science.gov (United States)

    Dokas, Ioannis M; Panagiotakopoulos, Demetrios C

    2006-08-01

    The available expertise on managing and operating solid waste management (SWM) facilities varies among countries and among types of facilities. Few experts are willing to record their experience, while few researchers systematically investigate the chains of events that could trigger operational failures in a facility; expertise acquisition and dissemination, in SWM, is neither popular nor easy, despite the great need for it. This paper presents a knowledge acquisition process aimed at capturing, codifying and expanding reliable expertise and propagating it to non-experts. The knowledge engineer (KE), the person performing the acquisition, must identify the events (or causes) that could trigger a failure, determine whether a specific event could trigger more than one failure, and establish how various events are related among themselves and how they are linked to specific operational problems. The proposed process, which utilizes logic diagrams (fault trees) widely used in system safety and reliability analyses, was used for the analysis of 24 common landfill operational problems. The acquired knowledge led to the development of a web-based expert system (Landfill Operation Management Advisor, http://loma.civil.duth.gr), which estimates the occurrence possibility of operational problems, provides advice and suggests solutions.

  20. Breakthrough Listen - A New Search for Life in the Universe

    Science.gov (United States)

    Worden, Pete

    On July 20, 2015 Yuri Milner and Stephen Hawking announced a new set of scientific initiatives - a SETI search called Breakthrough Listen and a contest to devise potential messages in response to a detection entitled Breakthrough Message. These are the first of several privately-funded Breakthrough Initiatives, designed to answer the fundamental science questions surrounding the origin, extent and nature of life in the universe. The initiatives are managed by the Breakthrough Prize Foundation. With Breakthrough Listen, Radio SETI observations have begun at the Green Bank Radio Telescope (GBT) and optical SETI at the Lick Observatory Automated Planet Finder (APF). Observations will soon commence at the CSIRO Parkes Radio Telescope. Other SETI instruments and observations are under consideration. In addition, several other initiatives are under development including an expanded search for life in the universe.

  1. Study on the man-operator characteristics in the peak identification problem in line spectra

    International Nuclear Information System (INIS)

    Gopych, P.M.; Sorokin, V.I.; Sotnikov, V.V.

    1992-01-01

    ATOS program complex (automatical test spectra processing) realizing all stages of investigation necessary to obtain qualitative characteristics of the man-operator in the peak identification problem is developed. Qualitative characteristics of identitication ion quality of peaks by operators searching for peaks in line spectra are determined due to simulation experiment. It is shown, that for trained operators reference possibility of false detection of peaks is equal to F=0.012±0.004, while for untrained ones - F≅0.3. Comparison of results with analogous data on on-line programs for identification of peaks in γ-spectra is conducted

  2. Cost-effective computations with boundary interface operators in elliptic problems

    International Nuclear Information System (INIS)

    Khoromskij, B.N.; Mazurkevich, G.E.; Nikonov, E.G.

    1993-01-01

    The numerical algorithm for fast computations with interface operators associated with the elliptic boundary value problems (BVP) defined on step-type domains is presented. The algorithm is based on the asymptotically almost optimal technique developed for treatment of the discrete Poincare-Steklov (PS) operators associated with the finite-difference Laplacian on rectangles when using the uniform grid with a 'displacement by h/2'. The approach can be regarded as an extension of the method proposed for the partial solution of the finite-difference Laplace equation to the case of displaced grids and mixed boundary conditions. It is shown that the action of the PS operator for the Dirichlet problem and mixed BVP can be computed with expenses of the order of O(Nlog 2 N) both for arithmetical operations and computer memory needs, where N is the number of unknowns on the rectangle boundary. The single domain algorithm is applied to solving the multidomain elliptic interface problems with piecewise constant coefficients. The numerical experiments presented confirm almost linear growth of the computational costs and memory needs with respect to the dimension of the discrete interface problem. 14 refs., 3 figs., 4 tabs

  3. Types of Motivating Operations in Interventions with Problem Behavior: A Systematic Review

    Science.gov (United States)

    Simo-Pinatella, David; Font-Roura, Josep; Planella-Morato, Joaquima; McGill, Peter; Alomar-Kurz, Elisabeth; Gine, Climent

    2013-01-01

    A motivating operation (MO) alters both the effectiveness of a stimulus as a reinforcer and the current frequency of all behavior that has been reinforced by that particular stimulus. This article reviews studies that have manipulated a MO during interventions with school-age participants with intellectual disabilities and problem behavior. A…

  4. Application of the annihilation and creation operators in magnetic resonance problems

    International Nuclear Information System (INIS)

    Nosel, W.

    1981-01-01

    Application of the annihilation and creation operators in the following problems is presented: in the resonance of the free spins in rotating and oscillating magnetic field, in the influence of the nonresonance magnetic fields on magnetic resonance, in the thermodynamics of the spins with dipolar interaction and in the nuclear magnetic relaxation. (author)

  5. Triple solutions for multi-point boundary-value problem with p-Laplace operator

    Directory of Open Access Journals (Sweden)

    Yansheng Liu

    2009-11-01

    Full Text Available Using a fixed point theorem due to Avery and Peterson, this article shows the existence of solutions for multi-point boundary-value problem with p-Laplace operator and parameters. Also, we present an example to illustrate the results obtained.

  6. Report to NASA Committee on Aircraft Operating Problems Relative to Aviation Safety Engineering and Research Activities

    Science.gov (United States)

    1963-01-01

    The following report highlights some of the work accomplished by the Aviation Safety Engineering and Research Division of the Flight Safety Foundations since the last report to the NASA Committee on Aircraft Operating Problems on 22 May 1963. The information presented is in summary form. Additional details may be provided upon request of the reports themselves may be obtained from AvSER.

  7. Robustness of Operational Matrices of Differentiation for Solving State-Space Analysis and Optimal Control Problems

    Directory of Open Access Journals (Sweden)

    Emran Tohidi

    2013-01-01

    Full Text Available The idea of approximation by monomials together with the collocation technique over a uniform mesh for solving state-space analysis and optimal control problems (OCPs has been proposed in this paper. After imposing the Pontryagins maximum principle to the main OCPs, the problems reduce to a linear or nonlinear boundary value problem. In the linear case we propose a monomial collocation matrix approach, while in the nonlinear case, the general collocation method has been applied. We also show the efficiency of the operational matrices of differentiation with respect to the operational matrices of integration in our numerical examples. These matrices of integration are related to the Bessel, Walsh, Triangular, Laguerre, and Hermite functions.

  8. Metropolis Parking Problems and Management Planning Solutions for Traffic Operation Effectiveness

    Directory of Open Access Journals (Sweden)

    Yuejun Liu

    2012-01-01

    Full Text Available Advances in mobility are clearly illustrated by the rapid development of urbanization and motorization in developing countries. Following the dramatic incensement of traffic demand, the parking problem has been becoming much more seriously important in many metropolises. With the aim of seeking solutions as to how the parking system could operate more efficiently by using new technologies and new methodologies, this paper discusses the application of geographic information system into the parking planning and management for traffic operation effectiveness in metropolis. The concentration of this paper includes the characteristics of parking demand and the causations of parking problems, especially the basic parking principle and strategies for solving parking problems from the perspective of geographic information system are discussed in enough detail in this paper.

  9. IE Information No. 86-71: Recent identified problems with Limitorque motor operators

    International Nuclear Information System (INIS)

    Jordan, E.L.

    1992-01-01

    This notice is provided to alert recipients of two potential problems discovered with Limitorque motor operators. On November 8, 1985 Georgia Power Company submitted a preliminary report to the NRC indicating that it had discovered burn damage to internal wiring in several Limitorque motor operators installed in their Vogtle Unit 1 Power Plant. On March 20, 1986 Georgia Power Company submitted a final report to the NRC which suggested that the burn damage was a generic problem applicable to all Limitorque motor operators. This assumption was based on a sampling inspection of 104 Limitorque motor operators installed in Vogtle Unit 1. Forty-six of the motor operators examined were Limitorque type SMB-000, and six of these were found to have burnt internal wiring. Out of the 58 operators other than type SMB-000 which were inspected, 5 were found to contain wires deemed susceptible to damage because of their close proximity to the heater elements (less than 1/2 inch). Several licensees have submitted reports to the NRC concerning a problem with cracked limit switch rotors on Limitorque motor operators installed inside and outside of containment. The limit switches are used for control of the motor operator and also provide indication of valve position in the control room. The cracks have been found on white melamine limit switch rotors. Most of these cracks were found in the area where the limit switch rotors are pinned to the pinion shafts. Some cracks have been found to extend halfway through the melamine rotors, weakening them to the extent that they are easily broken

  10. Building breakthrough businesses within established organizations.

    Science.gov (United States)

    Govindarajan, Vijay; Trimble, Chris

    2005-05-01

    Many companies assume that once they've launched a major innovation, growth will soon follow. It's not that simple. High-potential new businesses within established companies face stiff headwinds well after their inception. That's why a company's emphasis must shift: from ideas to execution and from leadership excellence to organizational excellence. The authors spent five years chronicling new businesses at the New York Times Company, Analog Devices, Corning, Hasbro, and other organizations. They found that a breakthrough new business (referred to as NewCo) rarely coexists gracefully with the established business in the company (called CoreCo). The unnatural combination creates three specific challenges--forgetting, borrowing, and learning--that NewCo must meet in order to survive and grow. NewCo must first forget some of what made CoreCo successful. NewCo and CoreCo have elemental differences, so NewCo must leave behind CoreCo's notions about what skills and competencies are most valuable. NewCo must also borrow some of CoreCo's assets--usually in one or two key areas that will give NewCo a crucial competitive advantage. Incremental cost reductions, for example, are never a sufficient justification for borrowing. Finally, NewCo must be prepared to learn some things from scratch. Because strategic experiments are highly uncertain endeavors, NewCo will face several critical unknowns. The more rapidly it can resolve those unknowns--that is, the faster it can learn--the sooner it will zero in on a winning business model or exit a hopeless situation. Managers can accelerate this learning by planning more simply and more often and by comparing predicted and actual trends.

  11. The United States: breakthroughs and waste.

    Science.gov (United States)

    Reinhardt, U E

    1992-01-01

    The health system of the United States is in a paradoxical position. At its best, the system is a magnet for those seeking the latest technical breakthroughs. It can offer that excellence because there have never been effective financial constraints on the imagination; the system has become a major economic frontier, at which professional and other entrepreneurs successfully seek their fortune. At the same time, the system is leaving increasing numbers of Americans frustrated and disillusioned. It is beset by excess capacity in many areas, is needlessly expensive, and often bestows unnecessary health services. Yet only the experts are aware of these flaws; most Americans still express high satisfaction with the quality of the services they receive from their doctors and hospitals. The public's major misgivings arise over the awkward and inequitable way in which American health care is financed. The typical private health insurance policy, for example, is tied to a particular job. If the job is lost, so is the health insurance. Furthermore, these policies are priced on actuarially "fair" principles, so sick individuals are forced to pay higher insurance premiums than relatively healthy ones and chronically ill persons often cannot obtain health insurance coverage at any price. Although there are public programs to catch many persons not privately insured, the coverage tends to be insufficiently extensive and deep. Some 35 million Americans, mostly poor, have no health insurance whatsoever. Unfortunately, at this time there is no political force in the United States strong enough to reform the American health system toward greater social equity and economic efficiency, whereas there are numerous groups powerful enough to block whatever reform might harm their own narrow economic interests. Other nations can learn from America's clinical and organizational innovations in health care delivery. They can also learn what not to do by studying the unseemly way in which

  12. Breakthrough characteristics of gas absorption in a packed column

    International Nuclear Information System (INIS)

    Shitanda, Shoji; Fukada, Satoshi; Koto, Kenji; Mitsuishi, Nobuo

    1979-01-01

    In nuclear industries, the operations to collect or recover various radioactive and non-radioactive gases with a number of absorption or adsorption reagents are practically utilized or planned. Specifically in the operations of recovering hydrogen isotopes, the direct collecting method with active metals such as uranium, zirconium (Zr) and yttrium is watched with keen interest. In this study, the capability of recovering hydrogen by means of Zr was investigated through the estimation of rate-determining step, by flowing the gas mixture of hydrogen and argon after activating metallic Zr under the condition of high temperature and high vacuum, and by determining overall mass transfer coefficient from the absorption breakthrough curves. The details of a packed column and the flowsheet are also described, and the deterioration of Zr powder is considered. That is, the diffusion speed and absorbing reaction speed of hydrogen in Zr particles are supposed to be slow and dominant in mass transfer speed. Further, since gas mixture does not simply diffuse in Zr particles, but the reaction plane seems to move toward the center from the surface in the case of Zr, different from general adsorbents, the moving speed seems to give large effect on the rate-determining step. It is ensured that the hydrogen absorption with Zr powder is so active that hydrogen in gas flow can easily be recovered, and its separation from other gases can be effectively carried out by the desorption of hydrogen from Zr powder by heating it in vacuum. (Wakatsuki, Y.)

  13. A Bankruptcy Problem Approach to Load-shedding in Multiagent-based Microgrid Operation

    Directory of Open Access Journals (Sweden)

    Yujin Lim

    2010-09-01

    Full Text Available A microgrid is composed of distributed power generation systems (DGs, distributed energy storage devices (DSs, and loads. To maintain a specific frequency in the islanded mode as an important requirement,  the control of DGs’ output and charge action of DSs are used in supply surplus conditions and load-shedding and discharge action of DSs are used in supply shortage conditions. Recently, multiagent systems for autonomous microgrid operation have been studied. Especially, load-shedding, which is intentional reduction of electricity use, is a critical problem in islanded microgrid operation based on the multiagent system. Therefore, effective schemes for load-shedding are required. Meanwhile, the bankruptcy problem deals with dividing short resources among multiple agents. In order to solve the bankruptcy problem, division rules, such as the constrained equal awards rule (CEA, the constrained equal losses rule (CEL, and the random arrival rule (RA, have been used. In this paper, we approach load-shedding as a bankruptcy problem. We compare load-shedding results by above-mentioned rules in islanded microgrid operation based on wireless sensor network (WSN as the communication link for an agent’s interactions.

  14. A bankruptcy problem approach to load-shedding in multiagent-based microgrid operation.

    Science.gov (United States)

    Kim, Hak-Man; Kinoshita, Tetsuo; Lim, Yujin; Kim, Tai-Hoon

    2010-01-01

    A microgrid is composed of distributed power generation systems (DGs), distributed energy storage devices (DSs), and loads. To maintain a specific frequency in the islanded mode as an important requirement, the control of DGs' output and charge action of DSs are used in supply surplus conditions and load-shedding and discharge action of DSs are used in supply shortage conditions. Recently, multiagent systems for autonomous microgrid operation have been studied. Especially, load-shedding, which is intentional reduction of electricity use, is a critical problem in islanded microgrid operation based on the multiagent system. Therefore, effective schemes for load-shedding are required. Meanwhile, the bankruptcy problem deals with dividing short resources among multiple agents. In order to solve the bankruptcy problem, division rules, such as the constrained equal awards rule (CEA), the constrained equal losses rule (CEL), and the random arrival rule (RA), have been used. In this paper, we approach load-shedding as a bankruptcy problem. We compare load-shedding results by above-mentioned rules in islanded microgrid operation based on wireless sensor network (WSN) as the communication link for an agent's interactions.

  15. Solution of operational problems utilization of an EX-IRT-2000 heat exchanger

    International Nuclear Information System (INIS)

    Razak, Abdu

    1986-01-01

    The Bandung TRIGA Mark II Reactor has been successfully operated for 21 years, especially in low power operation or as neutron sources for various experiments. Most of the operating time, approximately 80% of routine operation, was dedicated for radio-isotope production. During routine operation for radio-isotope production, the reactor could not be operated at full power. The reactor was operated at 60% of the maximum power (1 MWth) due to the inability of the original heat exchanger to operate properly. The reason is that slack deposition was built-up on the secondary side of the heat exchanger. Therefore, it reduced the coefficient of heat transfer considerably. To solve the problems, a set of heat exchanger including the pump was installed In parallel with the original unit. The heat exchanger was an IRT-2000 Reactor Heat exchanger which was collected from the abandoned IRT-2000 Project. The heat exchanger has capacity of 1.25 MW. The new heat exchanger could reduced the outlet temperature of the primary coolant Into 42 deg. C. While the original-heat exchanger at the worst condition and at 600 kW of power reach outlet temperature 49 deg. C. The IRT Heat Exchanger is a counter flow heat exchanger. (author)

  16. Solution of operational problems utilization of an EX-IRT-2000 heat exchanger

    Energy Technology Data Exchange (ETDEWEB)

    Razak, Abdu [Research Centre for Nuclear Techniques, National Atomic Energy Agency (Indonesia)

    1986-07-01

    The Bandung TRIGA Mark II Reactor has been successfully operated for 21 years, especially in low power operation or as neutron sources for various experiments. Most of the operating time, approximately 80% of routine operation, was dedicated for radio-isotope production. During routine operation for radio-isotope production, the reactor could not be operated at full power. The reactor was operated at 60% of the maximum power (1 MWth) due to the inability of the original heat exchanger to operate properly. The reason is that slack deposition was built-up on the secondary side of the heat exchanger. Therefore, it reduced the coefficient of heat transfer considerably. To solve the problems, a set of heat exchanger including the pump was installed In parallel with the original unit. The heat exchanger was an IRT-2000 Reactor Heat exchanger which was collected from the abandoned IRT-2000 Project. The heat exchanger has capacity of 1.25 MW. The new heat exchanger could reduced the outlet temperature of the primary coolant Into 42 deg. C. While the original-heat exchanger at the worst condition and at 600 kW of power reach outlet temperature 49 deg. C. The IRT Heat Exchanger is a counter flow heat exchanger. (author)

  17. The nonlocal problem for a hyperbolic equation with Bessel operator in a rectangular domain

    Directory of Open Access Journals (Sweden)

    Natalya V. Zaitseva

    2016-12-01

    Full Text Available We consider a boundary value problem for a hyperbolic equation with Bessel differential operator in a rectangular domain with integral nonlocal boundary value condition of the first kind. The equivalence between boundary value problem with integral nonlocal condition of the first kind and a local boundary value problem with mixed boundary conditions of the first and third kinds is proved. The existence and uniqueness of solution of the equivalent problem are established by means of the spectral method. At the uniqueness proof the completeness of the eigenfunction system of the spectral problem is used . At the existence proof the assessment of coefficients of series, the asymptotic formula for Bessel function of the first kind and asymptotic formula for eigenvalues are used. Sufficient conditions on the functions defining initial data of the problem are received. The solution of the problem is obtained in explicit form. The solution is obtained in the form of the Fourier–Bessel series. Its convergence is proved in the class of regular solutions.

  18. Factorization, Singular Operators and Related Problems : Conference in Honour of Professor Georgii Litvinchuk

    CERN Document Server

    Lebre, Amarino; Santos, António

    2003-01-01

    These proceedings comprise a large part of the papers presented at the International Conference Factorization, Singular Operators and related problems, which was held from January 28 to February 1, 2002, at the University of th Madeira, Funchal, Portugal, to mark Professor Georgii Litvinchuk's 70 birth­ day. Experts in a variety of fields came to this conference to pay tribute to the great achievements of Professor Georgii Litvinchuk in the development of vari­ ous areas of operator theory. The main themes of the conference were focussed around the theory of singular type operators and factorization problems, but other topics such as potential theory and fractional calculus, to name but a couple, were also presented. The goal of the conference was to bring together mathematicians from var­ ious fields within operator theory and function theory in order to highlight recent advances in problems many of which were originally studied by Profes­ sor Litvinchuk and his scientific school. A second aim was to sti...

  19. Cauchy problem for a parabolic equation with Bessel operator and Riemann–Liouville partial derivative

    Directory of Open Access Journals (Sweden)

    Fatima G. Khushtova

    2016-03-01

    Full Text Available In this paper Cauchy problem for a parabolic equation with Bessel operator and with Riemann–Liouville partial derivative is considered. The representation of the solution is obtained in terms of integral transform with Wright function in the kernel. It is shown that when this equation becomes the fractional diffusion equation, obtained solution becomes the solution of Cauchy problem for the corresponding equation. The uniqueness of the solution in the class of functions that satisfy the analogue of Tikhonov condition is proved.

  20. A new operational approach for solving fractional variational problems depending on indefinite integrals

    Science.gov (United States)

    Ezz-Eldien, S. S.; Doha, E. H.; Bhrawy, A. H.; El-Kalaawy, A. A.; Machado, J. A. T.

    2018-04-01

    In this paper, we propose a new accurate and robust numerical technique to approximate the solutions of fractional variational problems (FVPs) depending on indefinite integrals with a type of fixed Riemann-Liouville fractional integral. The proposed technique is based on the shifted Chebyshev polynomials as basis functions for the fractional integral operational matrix (FIOM). Together with the Lagrange multiplier method, these problems are then reduced to a system of algebraic equations, which greatly simplifies the solution process. Numerical examples are carried out to confirm the accuracy, efficiency and applicability of the proposed algorithm

  1. Electromagnetic Problems Solving by Conformal Mapping: A Mathematical Operator for Optimization

    Directory of Open Access Journals (Sweden)

    Wesley Pacheco Calixto

    2010-01-01

    Full Text Available Having the property to modify only the geometry of a polygonal structure, preserving its physical magnitudes, the Conformal Mapping is an exceptional tool to solve electromagnetism problems with known boundary conditions. This work aims to introduce a new developed mathematical operator, based on polynomial extrapolation. This operator has the capacity to accelerate an optimization method applied in conformal mappings, to determinate the equipotential lines, the field lines, the capacitance, and the permeance of some polygonal geometry electrical devices with an inner dielectric of permittivity ε. The results obtained in this work are compared with other simulations performed by the software of finite elements method, Flux 2D.

  2. Parameterizing the Spatial Markov Model From Breakthrough Curve Data Alone

    Science.gov (United States)

    Sherman, Thomas; Fakhari, Abbas; Miller, Savannah; Singha, Kamini; Bolster, Diogo

    2017-12-01

    The spatial Markov model (SMM) is an upscaled Lagrangian model that effectively captures anomalous transport across a diverse range of hydrologic systems. The distinct feature of the SMM relative to other random walk models is that successive steps are correlated. To date, with some notable exceptions, the model has primarily been applied to data from high-resolution numerical simulations and correlation effects have been measured from simulated particle trajectories. In real systems such knowledge is practically unattainable and the best one might hope for is breakthrough curves (BTCs) at successive downstream locations. We introduce a novel methodology to quantify velocity correlation from BTC data alone. By discretizing two measured BTCs into a set of arrival times and developing an inverse model, we estimate velocity correlation, thereby enabling parameterization of the SMM in studies where detailed Lagrangian velocity statistics are unavailable. The proposed methodology is applied to two synthetic numerical problems, where we measure all details and thus test the veracity of the approach by comparison of estimated parameters with known simulated values. Our results suggest that our estimated transition probabilities agree with simulated values and using the SMM with this estimated parameterization accurately predicts BTCs downstream. Our methodology naturally allows for estimates of uncertainty by calculating lower and upper bounds of velocity correlation, enabling prediction of a range of BTCs. The measured BTCs fall within the range of predicted BTCs. This novel method to parameterize the SMM from BTC data alone is quite parsimonious, thereby widening the SMM's practical applicability.

  3. Managing Conversations: The Medium for Achieving "Breakthrough" Results.

    Science.gov (United States)

    Bolton, Robert

    1998-01-01

    Unlike traditional management development, use of conversations in coaching high-performance work teams addresses core processes of speaking and listening. Management of conversations aims to create learning that will lead to breakthroughs in team performance. (SK)

  4. Identifying indicators of harmful and problem gambling in a Canadian sample through receiver operating characteristic analysis.

    Science.gov (United States)

    Quilty, Lena C; Avila Murati, Daniela; Bagby, R Michael

    2014-03-01

    Many gamblers would prefer to reduce gambling on their own rather than to adopt an abstinence approach within the context of a gambling treatment program. Yet responsible gambling guidelines lack quantifiable markers to guide gamblers in wagering safely. To address these issues, the current investigation implemented receiver operating characteristic (ROC) analysis to identify behavioral indicators of harmful and problem gambling. Gambling involvement was assessed in 503 participants (275 psychiatric outpatients and 228 community gamblers) with the Canadian Problem Gambling Index. Overall gambling frequency, duration, and expenditure were able to distinguish harmful and problematic gambling at a moderate level. Indicators of harmful gambling were generated for engagement in specific gambling activities: frequency of tickets and casino; duration of bingo, casino, and investments; and expenditures on bingo, casino, sports betting, games of skill, and investments. Indicators of problem gambling were similarly produced for frequency of tickets and casino, and expenditures on bingo, casino, games of skill, and investments. Logistic regression analyses revealed that overall gambling frequency uniquely predicted the presence of harmful and problem gambling. Furthermore, frequency indicators for tickets and casino uniquely predicted the presence of both harmful and problem gambling. Together, these findings contribute to the development of an empirically based method enabling the minimization of harmful or problem gambling through self-control rather than abstinence.

  5. Vertex operators, non-abelian orbifolds and the Riemann-Hilbert problem

    International Nuclear Information System (INIS)

    Gato, B.; Massachusetts Inst. of Tech., Cambridge

    1990-01-01

    We show how to construct the oscillator part of vertex operators for the bosonic string moving on non-abelian orbifolds, using the conserved charges method. When the three-string vertices are twisted by non-commuting group elements, the construction of the conserved charges becomes the Riemann-Hilbert problem with monodromy matrices given by the twists. This is solvable for any given configuration and any non-abelian orbifold. (orig.)

  6. Well-Posedness of Nonlocal Parabolic Differential Problems with Dependent Operators

    Directory of Open Access Journals (Sweden)

    Allaberen Ashyralyev

    2014-01-01

    Full Text Available The nonlocal boundary value problem for the parabolic differential equation v'(t+A(tv(t=f(t  (0≤t≤T,  v(0=v(λ+φ,  0<λ≤T in an arbitrary Banach space E with the dependent linear positive operator A(t is investigated. The well-posedness of this problem is established in Banach spaces C0β,γ(Eα-β of all Eα-β-valued continuous functions φ(t on [0,T] satisfying a Hölder condition with a weight (t+τγ. New Schauder type exact estimates in Hölder norms for the solution of two nonlocal boundary value problems for parabolic equations with dependent coefficients are established.

  7. Ensemble Kalman Filtering with Residual Nudging: An Extension to State Estimation Problems with Nonlinear Observation Operators

    KAUST Repository

    Luo, Xiaodong

    2014-10-01

    The ensemble Kalman filter (EnKF) is an efficient algorithm for many data assimilation problems. In certain circumstances, however, divergence of the EnKF might be spotted. In previous studies, the authors proposed an observation-space-based strategy, called residual nudging, to improve the stability of the EnKF when dealing with linear observation operators. The main idea behind residual nudging is to monitor and, if necessary, adjust the distances (misfits) between the real observations and the simulated ones of the state estimates, in the hope that by doing so one may be able to obtain better estimation accuracy. In the present study, residual nudging is extended and modified in order to handle nonlinear observation operators. Such extension and modification result in an iterative filtering framework that, under suitable conditions, is able to achieve the objective of residual nudging for data assimilation problems with nonlinear observation operators. The 40-dimensional Lorenz-96 model is used to illustrate the performance of the iterative filter. Numerical results show that, while a normal EnKF may diverge with nonlinear observation operators, the proposed iterative filter remains stable and leads to reasonable estimation accuracy under various experimental settings.

  8. Solving optimum operation of single pump unit problem with ant colony optimization (ACO) algorithm

    International Nuclear Information System (INIS)

    Yuan, Y; Liu, C

    2012-01-01

    For pumping stations, the effective scheduling of daily pump operations from solutions to the optimum design operation problem is one of the greatest potential areas for energy cost-savings, there are some difficulties in solving this problem with traditional optimization methods due to the multimodality of the solution region. In this case, an ACO model for optimum operation of pumping unit is proposed and the solution method by ants searching is presented by rationally setting the object function and constrained conditions. A weighted directed graph was constructed and feasible solutions may be found by iteratively searching of artificial ants, and then the optimal solution can be obtained by applying the rule of state transition and the pheromone updating. An example calculation was conducted and the minimum cost was found as 4.9979. The result of ant colony algorithm was compared with the result from dynamic programming or evolutionary solving method in commercial software under the same discrete condition. The result of ACO is better and the computing time is shorter which indicates that ACO algorithm can provide a high application value to the field of optimal operation of pumping stations and related fields.

  9. Harmonic voltage excess problem test and analysis in UHV and EHV grid particular operation mode

    Science.gov (United States)

    Lv, Zhenhua; Shi, Mingming; Fei, Juntao

    2018-02-01

    The test and analysis of the power quality of some 1000kV UHV transmission lines and 500kV EHV transmission lines is carried out. It is found that there is harmonic voltage excess problems when the power supply of the UHV and EHV voltage line is single-ended or single-loop, the problem basically disappeared after the operation mode change, different operating conditions, the harmonic current has not been greatly affected, indicating that the harmonic voltage changes mainly caused by the system harmonic impedance. With the analysis of MATLAB Simulink system model, it can be seen that there are specific harmonic voltage excess in the system under the specific operating mode, which results in serious distortion of the specific harmonic voltage. Since such phenomena are found in 500kV and 1000kV systems, it is suggested that the test evaluation work should be done under the typical mode of operation in 500kV, 1000kV Planning and construction process to prevent the occurrence of serious distortion and the regional harmonic current monitoring and suppression work should be done.

  10. Inverse source problem and null controllability for multidimensional parabolic operators of Grushin type

    International Nuclear Information System (INIS)

    Beauchard, K; Cannarsa, P; Yamamoto, M

    2014-01-01

    The approach to Lipschitz stability for uniformly parabolic equations introduced by Imanuvilov and Yamamoto in 1998 based on Carleman estimates, seems hard to apply to the case of Grushin-type operators of interest to this paper. Indeed, such estimates are still missing for parabolic operators degenerating in the interior of the space domain. Nevertheless, we are able to prove Lipschitz stability results for inverse source problems for such operators, with locally distributed measurements in an arbitrary space dimension. For this purpose, we follow a mixed strategy which combines the approach due to Lebeau and Robbiano, relying on Fourier decomposition and Carleman inequalities for heat equations with non-smooth coefficients (solved by the Fourier modes). As a corollary, we obtain a direct proof of the observability of multidimensional Grushin-type parabolic equations, with locally distributed observations—which is equivalent to null controllability with locally distributed controls. (paper)

  11. Breakthrough on technical and vocational education of Taiwan: Take Oriental Institute of Technology as an example

    Science.gov (United States)

    Chang, Horng-jinh; Wang, Whe-min

    2017-06-01

    Taiwan's economic strength has changed drastically in the past decade because of political and economic reasons; however, in order to cope with international environment, higher education must increase its breakthrough to meet the needs of enterprises. School curriculum also has to be timely changes and adjustments. This study will analyze school learning in several directions, use questionnaire to investigate students' learning stress, to find out where students' pressure lie. Also, outsourcing employers' satisfaction survey to find out what do enterprises wants to solve with the drop problem between school and enterprise. Taking Oriental Institute of Technology (OIT) as an example; over the past ten years, OIT has used overseas internships to help students overcome learning difficulties. Overseas practice courses include Penang Malaysia and Suzhou China had gained tremendous breakthrough.

  12. Cauchy problem for differential operators with double characteristics non-effectively hyperbolic characteristics

    CERN Document Server

    Nishitani, Tatsuo

    2017-01-01

    Combining geometrical and microlocal tools, this monograph gives detailed proofs of many well/ill-posed results related to the Cauchy problem for differential operators with non-effectively hyperbolic double characteristics. Previously scattered over numerous different publications, the results are presented from the viewpoint that the Hamilton map and the geometry of bicharacteristics completely characterizes the well/ill-posedness of the Cauchy problem. A doubly characteristic point of a differential operator P of order m (i.e. one where Pm = dPm = 0) is effectively hyperbolic if the Hamilton map FPm has real non-zero eigenvalues. When the characteristics are at most double and every double characteristic is effectively hyperbolic, the Cauchy problem for P can be solved for arbitrary lower order terms. If there is a non-effectively hyperbolic characteristic, solvability requires the subprincipal symbol of P to lie between − Pµj and P µj , where iµj are the positive imaginary eigenvalues of FPm ....

  13. Geopolitics of Quantum Buddhism: Our Pre-Hydrocarbon Tao Future (No Breakthrough at the Rio+20 Summit)

    Science.gov (United States)

    Bajrektarevic, Anis

    2013-01-01

    From Rio to Rio with Kyoto, Copenhagen and Durban in between, the conclusion remains the same: we fundamentally disagree on realities of this planet and the ways we can address them. A decisive breakthrough would necessitate both wider contexts and a larger participatory base so as to identify problems, formulate policies, and broaden and…

  14. The corona problem connections between operator theory, function theory, and geometry

    CERN Document Server

    Krantz, Steven; Sawyer, Eric; Treil, Sergei; Wick, Brett

    2014-01-01

    The purpose of the corona workshop was to consider the corona problem in both one and several complex variables, both in the context of function theory and harmonic analysis as well as the context of operator theory and functional analysis. It was held in June 2012 at the Fields Institute in Toronto, and attended by about fifty mathematicians. This volume validates and commemorates the workshop, and records some of the ideas that were developed within. The corona problem dates back to 1941. It has exerted a powerful influence over mathematical analysis for nearly 75 years. There is material to help bring people up to speed in the latest ideas of the subject, as well as historical material to provide background. Particularly noteworthy is a history of the corona problem, authored by the five organizers, that provides a unique glimpse at how the problem and its many different solutions have developed. There has never been a meeting of this kind, and there has never been a volume of this kind. Mathematicians—...

  15. Problems affecting the operational procurement process: A study of the Zimbabwean public sector

    Directory of Open Access Journals (Sweden)

    Abel Dzuke

    2017-02-01

    Full Text Available Background: The public sector occupies a key role in the economy comprising the appropriation of state revenue to purchase goods and to render services productively, while ensuring the optimum utilisation of available funds and resources to benefit the inhabitants of the country. Problems in the Zimbabwean public procurement sector that detract from service delivery are key contemporary issues. This is evident from the numerous complaints of poor service delivery received by the public that can be attributed to public procurement. Objective: The purpose of this article was to report on a study that investigated problems in the different stages of the operational procurement process in the Zimbabwean public sector that detract from service delivery, the extent of these problems and how the public procurement process can be improved to enhance service delivery. Method: This descriptive and exploratory study followed a quantitative approach. Data were collected by means of a questionnaire administered to all public entities in Zimbabwe. Data were analysed using SPSS. Results: The majority of the identified problems in the public procurement sector that detract from service delivery are found in the advertising, bid evaluation and contract stages. Conclusion: As only a few studies on this topic have been conducted in Zimbabwe, the findings of this research add a significant perspective to the existing body of knowledge and can assist stakeholders with regard to how the public procurement process can be improved in order to enhance service delivery through public procurement process reform and restructuring.

  16. A Posteriori Analysis of Adaptive Multiscale Operator Decomposition Methods for Multiphysics Problems

    Energy Technology Data Exchange (ETDEWEB)

    Donald Estep; Michael Holst; Simon Tavener

    2010-02-08

    This project was concerned with the accurate computational error estimation for numerical solutions of multiphysics, multiscale systems that couple different physical processes acting across a large range of scales relevant to the interests of the DOE. Multiscale, multiphysics models are characterized by intimate interactions between different physics across a wide range of scales. This poses significant computational challenges addressed by the proposal, including: (1) Accurate and efficient computation; (2) Complex stability; and (3) Linking different physics. The research in this project focused on Multiscale Operator Decomposition methods for solving multiphysics problems. The general approach is to decompose a multiphysics problem into components involving simpler physics over a relatively limited range of scales, and then to seek the solution of the entire system through some sort of iterative procedure involving solutions of the individual components. MOD is a very widely used technique for solving multiphysics, multiscale problems; it is heavily used throughout the DOE computational landscape. This project made a major advance in the analysis of the solution of multiscale, multiphysics problems.

  17. Types of motivating operations in interventions with problem behavior: a systematic review.

    Science.gov (United States)

    Simó-Pinatella, David; Font-Roura, Josep; Planella-Morató, Joaquima; McGill, Peter; Alomar-Kurz, Elisabeth; Giné, Climent

    2013-01-01

    A motivating operation (MO) alters both the effectiveness of a stimulus as a reinforcer and the current frequency of all behavior that has been reinforced by that particular stimulus. This article reviews studies that have manipulated a MO during interventions with school-age participants with intellectual disabilities and problem behavior. A systematic review was conducted using the following major electronic databases: PsychInfo, Education Resources Information Center, Science Direct, Blackwell, SAGE, and Medline. A total of 31 published articles representing 55 participants was examined. Findings from this study suggest that the modification of a MO usually has an effect on the problem behavior by either establishing or abolishing its motivation. Furthermore, a relationship was found between the type of MO and the behavioral function identified. The theoretical and practical implications of these findings, limitations of this study and potential issues for future research are discussed.

  18. Classical solutions of two dimensional Stokes problems on non smooth domains. 1: The Radon integral operators

    International Nuclear Information System (INIS)

    Lubuma, M.S.

    1991-05-01

    The applicability of the Neumann indirect method of potentials to the Dirichlet and Neumann problems for the two-dimensional Stokes operator on a non smooth boundary Γ is subject to two kinds of sufficient and/or necessary conditions on Γ. The first one, occurring in electrostatic, is equivalent to the boundedness on C(Γ) of the velocity double layer potential W as well as to the existence of jump relations of potentials. The second condition, which forces Γ to be a simple rectifiable curve and which, compared to the Laplacian, is a stronger restriction on the corners of Γ, states that the Fredholm radius of W is greater than 2. Under these conditions, the Radon boundary integral equations defined by the above mentioned jump relations are solvable by the Fredholm theory; the double (for Dirichlet) and the single (for Neumann) layer potentials corresponding to their solutions are classical solutions of the Stokes problems. (author). 48 refs

  19. A Heuristic Procedure for the Outbound Container Relocation Problem during Export Loading Operations

    Directory of Open Access Journals (Sweden)

    Roberto Guerra-Olivares

    2015-01-01

    Full Text Available During export ship loading operations, it is often necessary to perform relocation movements with containers that interfere with access to the desired container in the ship loading sequence. This paper presents a real-time heuristic procedure for the container relocation problem employing reachstacker vehicles as container handling equipment. The proposed heuristic searches for good relocation coordinates within a set of nearby bays. The heuristic has a parameter that determines how far from the original bay a container may be relocated. The tradeoff between reducing relocation movements and limiting vehicle travel distances is examined and the performance of the heuristic is compared with a common practice in the smaller container terminals in Chile and Mexico. Finally, a mathematical model for the container relocation problem is presented.

  20. Aldosterone breakthrough during aliskiren, valsartan, and combination (aliskiren + valsartan) therapy.

    Science.gov (United States)

    Bomback, Andrew S; Rekhtman, Yelena; Klemmer, Philip J; Canetta, Pietro A; Radhakrishnan, Jai; Appel, Gerald B

    2012-01-01

    Aldosterone levels increase in 30%-40% of patients on angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers over the long term. This "aldosterone breakthrough" may carry important clinical consequences given aldosterone's nonepithelial, pro-fibrotic actions. The renin inhibitor, aliskiren, by suppressing the renin-angiotensin-aldosterone system (RAAS) proximally, may limit breakthrough compared to conventional RAAS blockade. This open-label study (NCT01129557) randomized subjects to aliskiren 300 mg daily (A), valsartan 320 mg daily (V), or aliskiren 150 mg + valsartan 160 mg daily (A+V) for 9 months. Eligible subjects had proteinuria >300 mg/day, estimated glomerular filtration rate (eGFR) >45 mL/min/1.73 m(2), and systolic blood pressure (BP) >130 or diastolic BP >80 mm Hg. Serum and 24-hour urine aldosterone (indexed to 24-hour urine Na) were checked before initiation of therapy and at 3, 6, and 9 months. Aldosterone breakthrough was defined as a sustained increase from baseline aldosterone by study end. The study was intended to enroll 120 subjects but was terminated early by the sponsor. We present here the results of 33 subjects who completed the protocol, of which 12 were randomized to A, 11 were randomized to V, and 10 were randomized to A+V. Mean baseline eGFR was 75.5 (±23.3) mL/min/1.73 m(2); baseline proteinuria was 3104 (±2943) mg/day; and baseline BP was 134.7 (±10.5)/84.8 (±8.4) mm Hg. Three (27%) subjects on V, three (25%) subjects on A, and three (30%) subjects on A+V had aldosterone breakthrough. Mean proteinuria reduction was 31% from baseline in all subjects: 30% in subjects with breakthrough vs. 32% in subjects without breakthrough. Mean BP reduction was 11.0/8.8 mm Hg in all subjects: 8.4/6.1 mm Hg in subjects with breakthrough vs. 12.0/9.8 mm Hg in subjects without breakthrough. Aliskiren, alone or in combination with valsartan, did not reduce the incidence of aldosterone breakthrough in subjects with hypertension

  1. Spectral methods for a nonlinear initial value problem involving pseudo differential operators

    International Nuclear Information System (INIS)

    Pasciak, J.E.

    1982-01-01

    Spectral methods (Fourier methods) for approximating the solution of a nonlinear initial value problem involving pseudo differential operators are defined and analyzed. A semidiscrete approximation to the nonlinear equation based on an L 2 projection is described. The semidiscrete L 2 approximation is shown to be a priori stable and convergent under sufficient decay and smoothness assumptions on the initial data. It is shown that the semidiscrete method converges with infinite order, that is, higher order decay and smoothness assumptions imply higher order error bounds. Spectral schemes based on spacial collocation are also discussed

  2. Modeling Multioperator Multi-UAV Operator Attention Allocation Problem Based on Maximizing the Global Reward

    Directory of Open Access Journals (Sweden)

    Yuhang Wu

    2016-01-01

    Full Text Available This paper focuses on the attention allocation problem (AAP in modeling multioperator multi-UAV (MOMU, with the operator model and task properties taken into consideration. The model of MOMU operator AAP based on maximizing the global reward is established and used to allocate tasks to all operators as well as set work time and rest time to each task simultaneously for operators. The proposed model is validated in Matlab simulation environment, using the immune algorithm and dynamic programming algorithm to evaluate the performance of the model in terms of the reward value with regard to the work time, rest time, and task allocation. The result shows that the total reward of the proposed model is larger than the one obtained from previously published methods using local maximization and the total reward of our method has an exponent-like relation with the task arrival rate. The proposed model can improve the operators’ task processing efficiency in the MOMU command and control scenarios.

  3. Evaluation of diagnostic and operative problems in basal meningioma by two-plane CT and angiography

    International Nuclear Information System (INIS)

    Inoue, Hiroshi; Tamura, Masaru; Kawafuchi, Jun-ichi

    1982-01-01

    Basal meningiomas were investigated using two-plane computed tomography (CT) with an ordinary section combined with a reverse section to ascertain the precise site of the origin, size, extension, properties and relation to adjacent tissue. Furthermore, with information obtained from angiography, operative difficulty and operative indications were investigated, to determine a therapeutic policy taking neurofunctional prognosis into consideration. The factors directly affecting the operative difficulty were the large size of the tumor, deformity of the hypothamus and brain stem, supratentorial or infratentorial extension, bone erosion, calcification of the tumor, direct effect on the major vessels and high vascularity. It is considered to be difficult or impossible to perform operations in cases accompanied by more than three of these factors and, in the case of posterior fossa tumors, more than two. Tumor density, extent of enhancement, perifocal low-density, ventricular dilatation, transtentorial herniation, brain or brain stem displacement, bone erosion on CT scans as well as tumor vascularity, feeding arteries, and changes in the major vessels on angiograms were also studied, and therapeutic problems as well as their countermeasures regarding these findings were discussed. It is emphasized that obtaining more accurate information concerning the preoperative state is the first step towards the improvement of therapeutic results in basal meningiomas. (author)

  4. Indistinguishability Operators Applied to Task Allocation Problems in Multi-Agent Systems

    Directory of Open Access Journals (Sweden)

    José Guerrero

    2017-09-01

    Full Text Available In this paper we show an application of indistinguishability operators to model response functions. Such functions are used in the mathematical modeling of the task allocation problem in multi-agent systems when the stimulus, perceived by the agent, to perform a task is assessed by means of the response threshold model. In particular, we propose this kind of operators to represent a response function when the stimulus only depends on the distance between the agent and a determined task, since we prove that two celebrated response functions used in the literature can be reproduced by appropriate indistinguishability operators when the stimulus only depends on the distance to each task that must be carried out. Despite the fact there is currently no systematic method to generate response functions, this paper provides, for the first time, a theoretical foundation to generate them and study their properties. To validate the theoretical results, the aforementioned indistinguishability operators have been used to simulate, with MATLAB, the allocation of a set of tasks in a multi-robot system with fuzzy Markov chains.

  5. Major breakthrough in personal dust protection

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, J.

    2004-09-15

    With new studies highlighting one in every 20 miners developing 'black lung', USA labour, industry and government have joined forces to develop a solution. The rapid advance in Personal Dust Monitor (PDM) technology is a perfect example. The article reports a PDM, which is developed by the US National Institute for Occupational Safety and Health, working in the partnership with the United Mine Workers of America, the Bituminous Coal Operators Association and the National Mining Association.

  6. Oxygen sensor equipped engine operation on methanol/gasoline blends and phase separation problems

    Energy Technology Data Exchange (ETDEWEB)

    Last, A J; Lawson, A; Simmons, E W; Mackay, D; Tsang, M; Maund, G B

    1980-01-01

    A study was made to address problems related to Canadian utilization of methanol/gasoline blends. These problems are: (1) cold weather operation; (2) water sensitivity to phase separation in winter; (3) vehicle compatibility: fuel/air ratio control, flexibility for vehicle movement outside of areas where methanol might be available. Specifically, the operation of the HydroShear (an in-line hydraulic emulsifier) on the two separated phases of a methanol/gasoline/water blend was examined. Fuel maps, by engine dynamometer testing, were generated using methanol/gasoline blends containing 15% to 65% methanol. The capability of an oxygen sensor, located in the exhaust system, to control the fuel/air ratio was found to be adequate within the 15% to 65% methanol/gasoline blends. A fuel injected Volvo 244DL with lambda-sond emission control and a carburetted Chevrolet Monza with 3-way catalyst closed loop feedback emission control system were the two engines selected for this study.

  7. The 2001 HBR list. Breakthrough ideas for today's business agenda.

    Science.gov (United States)

    2001-04-01

    Business is shaped by ideas. But how do you separate enduring ideas from passing fancies? In this, the first edition of the annual HBR List, our editors spotlight five break-through ideas that are truly shaping the future of business. EVEN A GREAT BUSINESS MODEL IS NOT ENOUGH: The rise and fall of dot-coms left markets reeling and CEOs scratching their heads. The most important lesson of the debacle: squishy thinking about "business models" is no substitute for a distinctive strategy. CHANGE IS CHANGING: In recent years, pundits have urged executives to incite revolutions within their companies. But a growing group of experts now suggests that the best companies actually evolve through incremental change--change that builds on rather than subverts their heritage. EGO MAKES THE LEADER: By looking deeply into executives' psyches, we are beginning to unlock the enigma of leadership. While there will never be a single recipe for successful corporate stewardship, an understanding of the human ego can shed light on leadership's most fundamental components. ONLY CONNECT: In business organizations, what's really important about people is not their individual skills but the relationships they form with one another. By investing in "social capital," companies can often push their performance to a whole new level. THE BIOLOGY CENTURY DAWNS: In the twentieth century, product innovations tended to spring from physics. But in the new century, biology may be the central source of innovation. From genomics to biomimicry, the study of life promises to change what companies sell and even how they operate.

  8. The operating room case-mix problem under uncertainty and nurses capacity constraints.

    Science.gov (United States)

    Yahia, Zakaria; Eltawil, Amr B; Harraz, Nermine A

    2016-12-01

    Surgery is one of the key functions in hospitals; it generates significant revenue and admissions to hospitals. In this paper we address the decision of choosing a case-mix for a surgery department. The objective of this study is to generate an optimal case-mix plan of surgery patients with uncertain surgery operations, which includes uncertainty in surgery durations, length of stay, surgery demand and the availability of nurses. In order to obtain an optimal case-mix plan, a stochastic optimization model is proposed and the sample average approximation method is applied. The proposed model is used to determine the number of surgery cases to be weekly served, the amount of operating rooms' time dedicated to each specialty and the number of ward beds dedicated to each specialty. The optimal case-mix selection criterion is based upon a weighted score taking into account both the waiting list and the historical demand of each patient category. The score aims to maximizing the service level of the operating rooms by increasing the total number of surgery cases that could be served. A computational experiment is presented to demonstrate the performance of the proposed method. The results show that the stochastic model solution outperforms the expected value problem solution. Additional analysis is conducted to study the effect of varying the number of ORs and nurses capacity on the overall ORs' performance.

  9. Evaluating operator performance on full-scope simulators: A pragmatic approach to an intractable measurement problem

    International Nuclear Information System (INIS)

    Fuld, R.

    1989-01-01

    Industry trends toward full-scope, plant-referenced control room simulators have accelerated. The cost of such training is high, but the cost of training ineffectiveness is even higher if it permits serious errors or operator disqualification to occur. Effective measures of operator performance are needed, but the complexity of the task environment and the many aspects of and requirements for operator performance conspire to make such measurement a challenging problem. Combustion Engineering (C-E) Owners' Group task No. 572 was undertaken to develop a tractable and effective methodology for evaluating team performance in a requalification context on full-scope simulator scenarios. The following concepts were pursued as design goals for the method: 1. validity; 2. sensitivity; 3. reliability; 4. usability. In addition, the resulting approach was to meet the requirements of ES-601, Implementation Guidance of the NRC for Administration of Requalifying Exams. A survey of existing evaluation tools and techniques was made to determine the strengths and weaknesses of each. Based on those findings, a multimethod approach was developed drawing on the combined strengths of several general methods. The paper discusses procedural milestones, comments as subjective ratings, failure criteria, and tracked plant parameters

  10. Effect of operative treatment on psychosocial problems of men with gynaecomastia.

    Science.gov (United States)

    Kasielska, Anna; Antoszewski, Bogusław

    2011-11-01

    Gynaecomastia is defined as a hyperplasia of the breast tissue in men, bilateral or unilateral, usually not associated with the presence of malignant lesions.The aim of the study was to explore the psychosocial problems of men with gynecomastia and the effect of operative breast reduction on these problems.Material and methods. The survey was conducted in a group of 47 men who were treated surgically for gynaecomastia in the Department of Plastic, Reconstructive and Aesthetic Surgery. The mean age of the respondents was 25.6±3.5 years. For survey purposes, a questionnaire was developed with questions about the age of onset of gynaecomastia, coexisting disorders and medicines taken and also various aspects of the psychosocial life of the respondents. The questionnaire was completed by patients before surgery and at minimum 6 months after surgery.Results. The findings showed that in almost all patients gynaecomastia had caused emotional discomfort and limitation of everyday activity. In many patients, enlarged breasts caused difficulties in entering into social relationships. More than a half of the surveyed men admitted that their problems were ridiculed by others and they felt isolated. A comparison of the respondents' answers before and after the surgery showed statistically significant differences in all of the analysed questionnaire items.Conclusions. Gynaecomastia causes considerable emotional discomfort and limitation of everyday activity in young men, and that is why it constitutes a psychosocial problem. Surgical treatment of gynaecomastia significantly contributes to an increase in social activity and an improvement of social acceptance and emotional comfort, and thus significantly improves satisfaction from personal life in the men who underwent this intervention.

  11. Activity based costing the performance breakthrough

    CERN Document Server

    Turney, Peter B B

    1996-01-01

    Activity-based costing is a method of measuring the cost and performance of activities, products and customers. It is increasingly being seen as a more accurate method of costing than conventional costing systems, which are being superseded by the fact that automation means that direct material and labour consumption is now a far less accurate means of apportioning overheads. This practical book outlines why conventional cost systems fail, before going on to cover the advantages of activity-based costing, and describing how to put the system in place successfully, and how to apply the lessons learnt quickly. The book takes the reader step-by-step through the various processes involved, from setting up the system, through its operation, to evaluation of the results.

  12. High-pressure gas-breakthrough apparatus and a procedure for determining the gas-breakthrough pressure of compacted clay

    International Nuclear Information System (INIS)

    Hume, H.B.

    1997-08-01

    Gas may be produced in a nuclear fuel waste disposal vault. Given that the vault will be sealed with clay-based materials, the fate of the gas is uncertain. Therefore, an instrument was previously built to measure the pressure required to pass gas through compacted clay materials (a gas-breakthrough apparatus). However, the 10 MPa pressure limit of the apparatus was insufficient to test compacted buffer material at the density proposed in the Canadian concept for nuclear fuel waste disposal. Therefore, a high-pressure (50 Wa) gas-breakthrough apparatus was designed, constructed and installed. This report describes the components of the apparatus and the materials and procedures that are used for the gas-breakthrough tests. (author)

  13. Foreknowledge of breakthroughs science and technology foresight, and the early identification of areas of breakthrough

    International Nuclear Information System (INIS)

    Papon, P.

    2010-01-01

    The progress of science and technology has been so rapid in the last few decades that it receives especial attention in forecasting and foresight exercises. But, because they are too greatly in thrall to the dominant paradigms and hence favour a linear perspective, the experts who deal with these questions pay more attention to the future of technologies than to scientific advances and revolutions. The bulk of their work consists, then, in anticipating, by various different methods (Delphi surveys, Road-maps, etc.), at what date a particular technology might be available (without, however, always correctly gauging the conditions for its social appropriation or the applications to which it might be put). In this article, Pierre Papon expounds a much more original and promising approach for attempting to anticipate the discoveries that are likely radically to transform the fields of scientific knowledge by investigating the phenomena that may potentially lead to fundamental revolutions. After reminding us of the premonitory thinking of a number of authors - in the fields, for example, of genetics and computer science -, he endeavors to describe some of the dominant paradigms, particularly in quantum physics and molecular biology. In this way, he shows the advances they have made possible, and also their limitations, and explores what new scientific leaps forward might occur, bringing radically new technological breakthroughs between now and 2050. Papon reminds us, at the same time that, 'as science is not something isolated within society'; it has a duty to contribute to meeting the great challenges that face us - of work, health, nutrition and sustainable development, particularly where energy and climate are concerned. He therefore examines the ways in which future scientific and technological advances might provide solutions and how important it might be to 'translate the questions society poses into scientific questions'. He thus argues implicitly for strategic

  14. Application of the HGPT methodology of reactor operation problems with a nodal mixed method

    International Nuclear Information System (INIS)

    Baudron, A.M.; Bruna, G.B.; Gandini, A.; Lautard, J.J.; Monti, S.; Pizzigati, G.

    1998-01-01

    The heuristically based generalized perturbation theory (HGPT), to first and higher order, applied to the neutron field of a reactor system, is discussed in relation to quasistatic problems. This methodology is of particular interest in reactor operation. In this application it may allow an on-line appraisal of the main physical responses of the reactor system when subject to alterations relevant to normal system exploitation, e.g. control rod movement, and/or soluble boron concentration changes to be introduced, for instance, for compensating power level variations following electrical network demands. In this paper, after describing the main features of the theory, its implementation into the diffusion, 3D mixed dual nodal code MINOS of the SAPHYR system is presented. The results from a small scale investigation performed on a simplified PWR system corroborate the validity of the methodology proposed

  15. Operational aspects, results and problems associated with R/B testing at Gentilly 2

    International Nuclear Information System (INIS)

    Garceau, N.; Beaudoin, R.

    1991-01-01

    There are many methods, some more complex or difficult to deal with than others, to verify the containment building integrity. At G-2, we chose the temperature compensation method. Our selection criteria were: 1) the greater precision of this method; 2) the possibility of executing the test with the plant running at full power; 3) short period required for the test; 4) after the technique is understood, its simplicity of execution; 5) can be easily inserted in the normal operating test program with a minimum of personnel; 6) this technique can be used at both low and high pressure. In this presentation we will succinctly discuss the different phases of the technique such as: the background, the prerequisite, the problems, the results and, finally, we will give some recommendations to facilitate the use of this method

  16. Main problems experienced on diesel generators of French 900 MWe operating units

    Energy Technology Data Exchange (ETDEWEB)

    Dredemis, Geoffroy; Jude, Francois [Commissariat a l' Energie Atomique, centre d' Etudes Nucleaires de Fontenay-aux-Roses, Institut de Protection et Surete Nucleaire, Departement d' Analyse de Surete, B.P. No. 6, 92260 Fontenay-aux-Roses (France)

    1986-02-15

    Each unit of all the French nuclear power plant is equipped with two diesel emergency generator sets., For the totality of standards PWRs of 900 MWe, they are identical. We present in this communication the most significative failures met with diesel engines on operating units, such as rupture of fuel injection pipes, breaking of the connecting rods, and cylinder lubrication failures. All these incidents, which affected the emergency power sources of concerned units, had generic characteristics. In view of their potential consequences, it was proceeded in each case to an immediate control of the components concerned of all PWR 900 MWe diesel engines. At the same time, studies were started as to what modifications would permit to solve rapidly each one of the problems met with. (authors)

  17. Direct Breakthrough Curve Prediction From Statistics of Heterogeneous Conductivity Fields

    Science.gov (United States)

    Hansen, Scott K.; Haslauer, Claus P.; Cirpka, Olaf A.; Vesselinov, Velimir V.

    2018-01-01

    This paper presents a methodology to predict the shape of solute breakthrough curves in heterogeneous aquifers at early times and/or under high degrees of heterogeneity, both cases in which the classical macrodispersion theory may not be applicable. The methodology relies on the observation that breakthrough curves in heterogeneous media are generally well described by lognormal distributions, and mean breakthrough times can be predicted analytically. The log-variance of solute arrival is thus sufficient to completely specify the breakthrough curves, and this is calibrated as a function of aquifer heterogeneity and dimensionless distance from a source plane by means of Monte Carlo analysis and statistical regression. Using the ensemble of simulated groundwater flow and solute transport realizations employed to calibrate the predictive regression, reliability estimates for the prediction are also developed. Additional theoretical contributions include heuristics for the time until an effective macrodispersion coefficient becomes applicable, and also an expression for its magnitude that applies in highly heterogeneous systems. It is seen that the results here represent a way to derive continuous time random walk transition distributions from physical considerations rather than from empirical field calibration.

  18. Husserl's Illumination of the Breakthrough of Logical Investigations

    African Journals Online (AJOL)

    denise

    the example Husserl offers of the room where the lights go off in order to illuminate the breakthrough for ... correspondence theory of truth, and his main concern seems to be to ..... The advantage of Husserl's example is that it tries to situate the ...

  19. Application of the rainfall infiltration breakthrough (RIB) model for ...

    African Journals Online (AJOL)

    Application of the rainfall infiltration breakthrough (RIB) model for groundwater recharge estimation in west coastal South Africa. ... the data from Oudebosch with different rainfall and groundwater abstraction inputs are simulated to explore individual effects on water levels as well as recharge rate estimated on a daily basis.

  20. A European survey of oncology nurse breakthrough cancer pain practices

    NARCIS (Netherlands)

    Rustoen, Tone; Geerling, Jenske I.; Pappa, Theodora; Rundstrom, Carina; Weisse, Isolde; Williams, Sian C.; Zavratnik, Bostjan; Kongsgaard, Ulf E.; Wengstrom, Yvonne

    Purpose of the research: Breakthrough cancer pain (BTCP) is a prevalent type of pain in which the nurse can play an important role in improving patients' pain symptoms and overall well-being. Nurses' experience with BTCP (number of patients, and estimates of severity and frequency), the treatment of

  1. Dissolved CO2 Increases Breakthrough Porosity in Natural Porous Materials.

    Science.gov (United States)

    Yang, Y; Bruns, S; Stipp, S L S; Sørensen, H O

    2017-07-18

    When reactive fluids flow through a dissolving porous medium, conductive channels form, leading to fluid breakthrough. This phenomenon is caused by the reactive infiltration instability and is important in geologic carbon storage where the dissolution of CO 2 in flowing water increases fluid acidity. Using numerical simulations with high resolution digital models of North Sea chalk, we show that the breakthrough porosity is an important indicator of dissolution pattern. Dissolution patterns reflect the balance between the demand and supply of cumulative surface. The demand is determined by the reactive fluid composition while the supply relies on the flow field and the rock's microstructure. We tested three model scenarios and found that aqueous CO 2 dissolves porous media homogeneously, leading to large breakthrough porosity. In contrast, solutions without CO 2 develop elongated convective channels known as wormholes, with low breakthrough porosity. These different patterns are explained by the different apparent solubility of calcite in free drift systems. Our results indicate that CO 2 increases the reactive subvolume of porous media and reduces the amount of solid residual before reactive fluid can be fully channelized. Consequently, dissolved CO 2 may enhance contaminant mobilization near injection wellbores, undermine the mechanical sustainability of formation rocks and increase the likelihood of buoyance driven leakage through carbonate rich caprocks.

  2. A problem with problem solving: motivational traits, but not cognition, predict success on novel operant foraging tasks.

    Science.gov (United States)

    van Horik, Jayden O; Madden, Joah R

    2016-04-01

    Rates of innovative foraging behaviours and success on problem-solving tasks are often used to assay differences in cognition, both within and across species. Yet the cognitive features of some problem-solving tasks can be unclear. As such, explanations that attribute cognitive mechanisms to individual variation in problem-solving performance have revealed conflicting results. We investigated individual consistency in problem-solving performances in captive-reared pheasant chicks, Phasianus colchicus , and addressed whether success depends on cognitive processes, such as trial-and-error associative learning, or whether performances may be driven solely via noncognitive motivational mechanisms, revealed through subjects' willingness to approach, engage with and persist in their interactions with an apparatus, or via physiological traits such as body condition. While subjects' participation and success were consistent within the same problems and across similar tasks, their performances were inconsistent across different types of task. Moreover, subjects' latencies to approach each test apparatus and their attempts to access the reward were not repeatable across trials. Successful individuals did not improve their performances with experience, nor were they consistent in their techniques in repeated presentations of a task. However, individuals that were highly motivated to enter the experimental chamber were more likely to participate. Successful individuals were also faster to approach each test apparatus and more persistent in their attempts to solve the tasks than unsuccessful individuals. Our findings therefore suggest that individual differences in problem-solving success can arise from inherent motivational differences alone and hence be achieved without inferring more complex cognitive processes.

  3. XY vs X Mixer in Quantum Alternating Operator Ansatz for Optimization Problems with Constraints

    Science.gov (United States)

    Wang, Zhihui; Rubin, Nicholas; Rieffel, Eleanor G.

    2018-01-01

    Quantum Approximate Optimization Algorithm, further generalized as Quantum Alternating Operator Ansatz (QAOA), is a family of algorithms for combinatorial optimization problems. It is a leading candidate to run on emerging universal quantum computers to gain insight into quantum heuristics. In constrained optimization, penalties are often introduced so that the ground state of the cost Hamiltonian encodes the solution (a standard practice in quantum annealing). An alternative is to choose a mixing Hamiltonian such that the constraint corresponds to a constant of motion and the quantum evolution stays in the feasible subspace. Better performance of the algorithm is speculated due to a much smaller search space. We consider problems with a constant Hamming weight as the constraint. We also compare different methods of generating the generalized W-state, which serves as a natural initial state for the Hamming-weight constraint. Using graph-coloring as an example, we compare the performance of using XY model as a mixer that preserves the Hamming weight with the performance of adding a penalty term in the cost Hamiltonian.

  4. Dresses problems arising from hot-plant operation and their solution (1961)

    International Nuclear Information System (INIS)

    Rodier, J.; Bouzigues, H.; Boutot, P.

    1961-01-01

    This article deals with effective methods to struggle radioactive contamination using rationally designed working clothes. The choice of the cloth is important and cotton, because of its absorbent properties constitutes an effective barrier to radioelements failing on its surface. Clothing the personnel of large nuclear industrial concerns is a big problem which can only be solved by carefully studied methods. The decontamination and washing of large amounts of clothes whose flow increases during periods of radio-active incidents have to be treated as are those operations in hospital laundering. Linen washing by the German counter-current method (the Sulzman system) is of great value because of the volume which can be treated and, more important, because of the small amount of liquid waste produced. Dry cleaning is certainly a method of the future and is even more economic than the preceding one. In 'active' laundries, the control of clothing for residual contamination can constitute a serious bottleneck in the production of clean clothing if automatic high-speed machines are not used. The risk to the operating personnel comes solely from contamination of the atmosphere and of the surfaces. Because of this, the plant must be considered as an active zone in which are handled several tens of millicuries of dangerous emitters and several micro- curies of plutonium daily. (authors) [fr

  5. Breakthrough Energy Savings with Waterjet Technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee W. Saperstein; R. Larry Grayson; David A. Summers; Jorge Garcia-Joo; Greg Sutton; Mike Woodward; T.P. McNulty

    2007-05-15

    , in turn, reduced the ability to apply detailed statistical tests to the product outcomes. Nonetheless, a regression analysis showed that operating pressures between 105 (10,000psi) and 140 (15,000psi) MegaPascals (MPa) at traverse speeds no greater than 10 cm/min (4 in/min), best generated the target result. Variation in other parameters, rotation speed, nozzle diameter, and nozzle separation angle, during the preliminary tests did not substantially change the product, and so were kept fixed during the ore mining tests. The experimental protocols were developed to include proper treatment of the lead-bearing materials, which may be considered hazardous. In anticipation of the creation of a mineral processing design for separation of the concentrates from the tailings (waste), assays were made of the metal content of each screen size for each of the 21 runs; with three screens and a pan for undersize, to give a total of 84 assays. This information will enable Dr. McNulty, project consultant, to create a flow sheet for the prototype mining machine. As a preliminary component to such a system, the experimental layout included a product-recovery system that delivered all of the fragmented product to the nest of screens which allowed study of the liberation at the different size levels. Where incomplete liberation is found, a secondary process was demonstrated for using pressurized cavitation to further comminute the material. This concept was successfully demonstrated, with a small cavitation chamber illustrating the much smaller space that such a tool requires, relative to conventional ball and rod mills. Additional testing is ongoing, external to this program, to find whether an one-step process using higher jet pressures and longer dwell times to achieve all the required comminution in mining, is more efficient than a two-step process in which normal jet pressures and feed rates do the initial mining, but full particle liberation is achieved only through secondary

  6. Performance impact of mutation operators of a subpopulation-based genetic algorithm for multi-robot task allocation problems.

    Science.gov (United States)

    Liu, Chun; Kroll, Andreas

    2016-01-01

    Multi-robot task allocation determines the task sequence and distribution for a group of robots in multi-robot systems, which is one of constrained combinatorial optimization problems and more complex in case of cooperative tasks because they introduce additional spatial and temporal constraints. To solve multi-robot task allocation problems with cooperative tasks efficiently, a subpopulation-based genetic algorithm, a crossover-free genetic algorithm employing mutation operators and elitism selection in each subpopulation, is developed in this paper. Moreover, the impact of mutation operators (swap, insertion, inversion, displacement, and their various combinations) is analyzed when solving several industrial plant inspection problems. The experimental results show that: (1) the proposed genetic algorithm can obtain better solutions than the tested binary tournament genetic algorithm with partially mapped crossover; (2) inversion mutation performs better than other tested mutation operators when solving problems without cooperative tasks, and the swap-inversion combination performs better than other tested mutation operators/combinations when solving problems with cooperative tasks. As it is difficult to produce all desired effects with a single mutation operator, using multiple mutation operators (including both inversion and swap) is suggested when solving similar combinatorial optimization problems.

  7. Convergence rates and finite-dimensional approximations for nonlinear ill-posed problems involving monotone operators in Banach spaces

    International Nuclear Information System (INIS)

    Nguyen Buong.

    1992-11-01

    The purpose of this paper is to investigate convergence rates for an operator version of Tikhonov regularization constructed by dual mapping for nonlinear ill-posed problems involving monotone operators in real reflective Banach spaces. The obtained results are considered in combination with finite-dimensional approximations for the space. An example is considered for illustration. (author). 15 refs

  8. On the convex closed set-valued operators in Banach spaces and their applications in control problems

    International Nuclear Information System (INIS)

    Vu Ngoc Phat; Jong Yeoul Park

    1995-10-01

    The paper studies a class of set-values operators with emphasis on properties of their adjoints and existence of eigenvalues and eigenvectors of infinite-dimensional convex closed set-valued operators. Sufficient conditions for existence of eigenvalues and eigenvectors of set-valued convex closed operators are derived. These conditions specify possible features of control problems. The results are applied to some constrained control problems of infinite-dimensional systems described by discrete-time inclusions whose right-hand-sides are convex closed set- valued functions. (author). 8 refs

  9. A short-term operating room surgery scheduling problem integrating multiple nurses roster constraints.

    Science.gov (United States)

    Xiang, Wei; Yin, Jiao; Lim, Gino

    2015-02-01

    Operating room (OR) surgery scheduling determines the individual surgery's operation start time and assigns the required resources to each surgery over a schedule period, considering several constraints related to a complete surgery flow and the multiple resources involved. This task plays a decisive role in providing timely treatments for the patients while balancing hospital resource utilization. The originality of the present study is to integrate the surgery scheduling problem with real-life nurse roster constraints such as their role, specialty, qualification and availability. This article proposes a mathematical model and an ant colony optimization (ACO) approach to efficiently solve such surgery scheduling problems. A modified ACO algorithm with a two-level ant graph model is developed to solve such combinatorial optimization problems because of its computational complexity. The outer ant graph represents surgeries, while the inner graph is a dynamic resource graph. Three types of pheromones, i.e. sequence-related, surgery-related, and resource-related pheromone, fitting for a two-level model are defined. The iteration-best and feasible update strategy and local pheromone update rules are adopted to emphasize the information related to the good solution in makespan, and the balanced utilization of resources as well. The performance of the proposed ACO algorithm is then evaluated using the test cases from (1) the published literature data with complete nurse roster constraints, and 2) the real data collected from a hospital in China. The scheduling results using the proposed ACO approach are compared with the test case from both the literature and the real life hospital scheduling. Comparison results with the literature shows that the proposed ACO approach has (1) an 1.5-h reduction in end time; (2) a reduction in variation of resources' working time, i.e. 25% for ORs, 50% for nurses in shift 1 and 86% for nurses in shift 2; (3) an 0.25h reduction in

  10. Main animal welfare problems in ruminant livestock during preslaughter operations: a South American view.

    Science.gov (United States)

    Gallo, C B; Huertas, S M

    2016-02-01

    Animals destined for meat production are usually exposed to many stressful conditions during production and particularly during preslaughter operations. Handling animals on farm, loading into and unloading from vehicles, transportation, passing through livestock markets, fasting, lairage and stunning can all affect their welfare. How badly welfare can be affected will depend on both the intrinsic factors of the specific type of animal involved and the extrinsic factors of the environment where those animals live or are being handled, including the animal handlers. In South America (SA), it has been part of a strategy for improving animal welfare (AW) to address not only ethical aspects, but to emphasize the close relationship existing between handling ruminants preslaughter and the quantity and quality of the meat they produce. This has resulted not only in improvements in AW, but has also brought economic rewards to producers which in turn can lead to higher incomes for them and hence better human welfare. For producers with a high number of animals, considering AW during production and preslaughter operations can determine the possibility of exporting and/or getting better prices for their products. At smallfarmer level, particularly in some less developed countries, where human welfare is impaired, using this strategy together with education has also been relevant. It is important that education and training in AW are done not only considering global knowledge, but also including specific geographical and climatic characteristics of each country and the cultural, religious and socio-economical characteristics of its people; therefore, research within the context of each country or region becomes relevant. The aim of this review was to show the results of research dealing with AW of ruminant livestock in Chile and some other SA countries. Some of the main problems encountered are related to lack of proper infrastructure to handle animals; long distance transport

  11. Coordination Scheme for Restructuring Business Operation of the Single Period Newsvendor Problem

    Directory of Open Access Journals (Sweden)

    Chiuh-Cheng Chyu

    2013-01-01

    Full Text Available This paper presents a coordination scheme for a single period newsvendor problem when both supplier and retailer of the supply chain agree to change the business operation from a market decision power sharing system (Model 1 to a unique decision maker system (Model 2. The supplier is assumed to be a risk-averse decision maker and he will undertake the product quality risk in both models. Model 1 is game theoretic, where the supplier controls the wholesale price, but the retailer controls the order quantity and market price. The bargaining process ends when the supplier has found a wholesale price that maximizes the value of his sales revenue minus the product quality cost. Model 2 is a centralized system where the supplier possesses all decision powers of the market. In general, Model 2 will generate higher total revenue than Model 1. The aim of this research is to propose a satisfying compromise based on consignment policy to resolve the revenue-sharing conflict in Model 2 due to the additional revenue. An example is provided to illustrate the two models and the proposed coordination scheme, along with managerial insights on the models’ benefits. The impacts of several parameters on the scheme are also presented and discussed.

  12. A review on Anticipated Breakthrough Technologies of 21st Century

    OpenAIRE

    Aithal P. S.; Shubhrajyotsna Aithal

    2016-01-01

    This review discuss strategic management of thirteen most anticipated possible technology breakthroughs of 21st century which are substantially affect the life style of living beings in the world like (1) Nanotechnology-based human life comfort, (2) High speed computation through optical computers, (3) Embedded Intelligence, (4) HIV Antivirus, (5) Pseudo Senses - Sensation of existence through virtual reality and through artificial environment, (6) Off Planet Production in micro-gravity, (7) ...

  13. Ten Main Technological Breakthroughs of CNPC in 2009

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Breakthrough in systematic technology for exploration of Qikou oil-enriched depression in Bohai Bay Basin Qikou oil-enriched depression is one of the largest depressions of the Tertiary deposit in Bohai Bay Basin.The oil and gas exploration of this area faces a number of bottlenecks,such as a large proportion of negative structures,complicated distribution of sedimentary sand bodies and diversified types of oil and gas reservoirs.

  14. Breakthrough innovations : The impact of foreign acquisition of knowledge

    OpenAIRE

    Tojeiro Rivero, Damián; Moreno Serrano, Rosina; Badillo Enciso, Erika Raquel

    2016-01-01

    Based on the Spanish Technological Innovation Panel, this paper explores the role of R+D offshoring on innovation performance from 2004 to 2013. Specifically, we focus our attention on the impact of different types of offshoring governance models on the profitability of developing breakthrough innovations. Using a novel methodology for panel data sets, we control for the heterogeneity of firms as well as for the sample selection and endogeneity. Our study provides evidence that firms developi...

  15. New AIDA-2020 call for breakthrough detector technologies

    CERN Multimedia

    2016-01-01

    Physicists, engineers, and industry will be interested in a new proof-of-concept fund for breakthrough projects from the general field of detector development and testing.   Launched in the framework of the European project AIDA-2020, this open call will provide up to 200k€ of seed funding to support innovative and societal applications with a focus on industry-oriented applications. The deadline for applying is 20 October 2016. More information here.

  16. Methodology for Examining Potential Technology Breakthroughs for Mitigating CO2 and Application to Centralized Solar Photovoltaics

    Science.gov (United States)

    Aggressive reductions in US greenhouse gas emissions will require radical changes in how society generates and uses energy. Technological breakthroughs will be necessary if we are to make this transition cost effectively. With limited resources, understanding the breakthrough pot...

  17. The SolarPACES strategy for the solar thermal breakthrough

    Energy Technology Data Exchange (ETDEWEB)

    Burch, G.D. [U.S. Department of Energy, Washington, DC (United States)

    1997-12-31

    Our national solar thermal research programs and our combined efforts conducted through IEA/SolarPACES have brought about many breakthroughs in the development of solar thermal technology. We have components and systems that are much more efficient, much more reliable, and can be built much more cost-efficiently than just a few years ago. As our technology development proceeds, we undoubtedly will continue to make significant progress, breakthroughs in fact, in all these areas - progress that will bring us even closer to economic parity with more conventional forms of energy. And while this progress is absolutely necessary, the question is whether it will be enough to allow solar thermal to break into the mainstream of global energy supply. Our new IEA/SolarPACES strategy, crafted and approved over the course of the past year, has recognized the changes we must face and given us license to begin to make those changes. We must begin addressing financial hurdles, work to create a more favorable regulatory and tax environment, support development of international partnerships, and expand the visibility and excitement of solar thermal technology to achieve the final breakthroughs we need to allow solar thermal energy to live up to its vast potential. (orig./AKF)

  18. Hybrid Proximal-Point Methods for Zeros of Maximal Monotone Operators, Variational Inequalities and Mixed Equilibrium Problems

    Directory of Open Access Journals (Sweden)

    Kriengsak Wattanawitoon

    2011-01-01

    Full Text Available We prove strong and weak convergence theorems of modified hybrid proximal-point algorithms for finding a common element of the zero point of a maximal monotone operator, the set of solutions of equilibrium problems, and the set of solution of the variational inequality operators of an inverse strongly monotone in a Banach space under different conditions. Moreover, applications to complementarity problems are given. Our results modify and improve the recently announced ones by Li and Song (2008 and many authors.

  19. Solving the multiple-set split equality common fixed-point problem of firmly quasi-nonexpansive operators.

    Science.gov (United States)

    Zhao, Jing; Zong, Haili

    2018-01-01

    In this paper, we propose parallel and cyclic iterative algorithms for solving the multiple-set split equality common fixed-point problem of firmly quasi-nonexpansive operators. We also combine the process of cyclic and parallel iterative methods and propose two mixed iterative algorithms. Our several algorithms do not need any prior information about the operator norms. Under mild assumptions, we prove weak convergence of the proposed iterative sequences in Hilbert spaces. As applications, we obtain several iterative algorithms to solve the multiple-set split equality problem.

  20. Safety management in multiemployer worksites in the manufacturing industry: opinions on co-operation and problems encountered.

    Science.gov (United States)

    Nenonen, Sanna; Vasara, Juha

    2013-01-01

    Co-operation between different parties and effective safety management play an important role in ensuring safety in multiemployer worksites. This article reviews safety co-operation and factors complicating safety management in Finnish multiemployer manufacturing worksites. The paper focuses on the service providers' opinions; however, a comparison of the customers' views is also presented. The results show that safety-related co-operation between providers and customers is generally considered as successful but strongly dependent on the partner. Safety co-operation is provided through, e.g., training, orientation and risk analysis. Problems encountered include ensuring adequate communication, identifying hazards, co-ordinating work tasks and determining responsibilities. The providers and the customers encounter similar safety management problems. The results presented in this article can help companies to focus their efforts on the most problematic points of safety management and to avoid common pitfalls.

  1. Fundamental Problems in the Operation of the Automotive Parts Industry Small and Medium Businesses in Bangkok and Surrounding Provinces

    OpenAIRE

    P. Thepnarintra

    2015-01-01

    The purposes of this study were to: 1) investigate operation conditions of SME automotive part industry in Bangkok and vicinity and 2) to compare operation problem levels of SME automotive part industry in Bangkok and vicinity according to the sizes of the enterprises. Samples in this study included 196 entrepreneurs of SME automotive part industry in Bangkok and vicinity derived from simple random sampling and calculation from R. V. Krejcie and D. W. Morgan's tables. Res...

  2. Cognitive modeling and dynamic probabilistic simulation of operating crew response to complex system accidents. Part 4: IDAC causal model of operator problem-solving response

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.H.J. [Center for Risk and Reliability, University of Maryland, College Park, MD 20742 (United States) and Paul Scherrer Institute, 5232 Villigen PSI (Switzerland)]. E-mail: yhc@umd.edu; Mosleh, A. [Center for Risk and Reliability, University of Maryland, College Park, MD 20742 (United States)

    2007-08-15

    This is the fourth in a series of five papers describing the Information, Decision, and Action in Crew context (IDAC) operator response model for human reliability analysis. An example application of this modeling technique is also discussed in this series. The model has been developed to probabilistically predicts the responses of a nuclear power plant control room operating crew in accident conditions. The operator response spectrum includes cognitive, emotional, and physical activities during the course of an accident. This paper assesses the effects of the performance-influencing factors (PIFs) affecting the operators' problem-solving responses including information pre-processing (I), diagnosis and decision making (D), and action execution (A). Literature support and justifications are provided for the assessment on the influences of PIFs.

  3. Cognitive modeling and dynamic probabilistic simulation of operating crew response to complex system accidents. Part 4: IDAC causal model of operator problem-solving response

    International Nuclear Information System (INIS)

    Chang, Y.H.J.; Mosleh, A.

    2007-01-01

    This is the fourth in a series of five papers describing the Information, Decision, and Action in Crew context (IDAC) operator response model for human reliability analysis. An example application of this modeling technique is also discussed in this series. The model has been developed to probabilistically predicts the responses of a nuclear power plant control room operating crew in accident conditions. The operator response spectrum includes cognitive, emotional, and physical activities during the course of an accident. This paper assesses the effects of the performance-influencing factors (PIFs) affecting the operators' problem-solving responses including information pre-processing (I), diagnosis and decision making (D), and action execution (A). Literature support and justifications are provided for the assessment on the influences of PIFs

  4. Global gradient estimates for divergence-type elliptic problems involving general nonlinear operators

    Science.gov (United States)

    Cho, Yumi

    2018-05-01

    We study nonlinear elliptic problems with nonstandard growth and ellipticity related to an N-function. We establish global Calderón-Zygmund estimates of the weak solutions in the framework of Orlicz spaces over bounded non-smooth domains. Moreover, we prove a global regularity result for asymptotically regular problems which are getting close to the regular problems considered, when the gradient variable goes to infinity.

  5. Algorithm for complete enumeration based on a stroke graph to solve the supply network configuration and operations scheduling problem

    Directory of Open Access Journals (Sweden)

    Julien Maheut

    2013-07-01

    Full Text Available Purpose: The purpose of this paper is to present an algorithm that solves the supply network configuration and operations scheduling problem in a mass customization company that faces alternative operations for one specific tool machine order in a multiplant context. Design/methodology/approach: To achieve this objective, the supply chain network configuration and operations scheduling problem is presented. A model based on stroke graphs allows the design of an algorithm that enumerates all the feasible solutions. The algorithm considers the arrival of a new customized order proposal which has to be inserted into a scheduled program. A selection function is then used to choose the solutions to be simulated in a specific simulation tool implemented in a Decision Support System. Findings and Originality/value: The algorithm itself proves efficient to find all feasible solutions when alternative operations must be considered. The stroke structure is successfully used to schedule operations when considering more than one manufacturing and supply option in each step. Research limitations/implications: This paper includes only the algorithm structure for a one-by-one, sequenced introduction of new products into the list of units to be manufactured. Therefore, the lotsizing process is done on a lot-per-lot basis. Moreover, the validation analysis is done through a case study and no generalization can be done without risk. Practical implications: The result of this research would help stakeholders to determine all the feasible and practical solutions for their problem. It would also allow to assessing the total costs and delivery times of each solution. Moreover, the Decision Support System proves useful to assess alternative solutions. Originality/value: This research offers a simple algorithm that helps solve the supply network configuration problem and, simultaneously, the scheduling problem by considering alternative operations. The proposed system

  6. Communication problems between local authorities and population in the zone of anti-terrorist operation

    Directory of Open Access Journals (Sweden)

    I. M. Dolya

    2015-12-01

    Full Text Available In the context of restoration of government framework and local authorities in the regions prone to external aggression, special attention should be paid to the study of the problem of organisation of communication between public authorities and local population. It is the dialogue and the effective exchange of information between the population and the local authorities that constitute one of the major pillars of reintegration of Donbass territories, covered by the antiterrorist operation, into Ukraine; the regional specifics of the given territories is the anarchy resulting from withdrawal of the local government bodies that were legally elected yet in 2010. In fact, escape of heads and deputies of local councils in the most challenging period in life of the region catalysed the local people, reinforcing the sense of insecurity and understanding the betrayal of representatives of local government bodies. Thus, the issues of enhancement of communication channels effectiveness, which were still burning before the beginning of the external aggression and the partial occupation of Donbass, have been compounded today by the problem of establishment of communication channels between the population and the new Ukrainian local authorities nearly from scratch. This needs to take into account that the armed conflict conditions remain and, obviously, leave their imprint on social interaction within local communities. At the same time, it is the development of communication in the ATO zone, especially in the areas that underwent occupation or were released, which may form the basis for the harmonious entry of the citizens into the Ukrainian socium. Establishment of civil­military administrations (CMAs with the purpose to temporarily substitute the non­functioning local authorities in Donbass is the unique experience for Ukraine. Despite legal recognition of rights and duties of local government bodies, it should be understood that CMAs act in terms of

  7. [The social hygiene problems in the operator work of hydroelectric power station workers and the means for enhancing work capacity].

    Science.gov (United States)

    Karakashian, A N; Lepeshkina, T R; Ratushnaia, A N; Glushchenko, S S; Zakharenko, M I; Lastovchenko, V B; Diordichuk, T I

    1993-01-01

    Weight, tension and harmfulness of professional activity, peculiarities of labour conditions and characteristics of work, shift dynamics of operative personnel's working capacity were studied in the course of 8-hour working day currently accepted at hydroelectric power stations (HEPS) and experimental 12-hour schedule. Working conditions classified as "admissible", positive dynamics of operators' state, their social and material contentment were a basis for 12-hour two-shift schedule to be recommended as more appropriate. At the same time, problem of optimal shift schedules for operative personnel of HEPS remains unsolved and needs to be further explored.

  8. Well-posedness of nonlocal parabolic differential problems with dependent operators.

    Science.gov (United States)

    Ashyralyev, Allaberen; Hanalyev, Asker

    2014-01-01

    The nonlocal boundary value problem for the parabolic differential equation v'(t) + A(t)v(t) = f(t) (0 ≤ t ≤ T), v(0) = v(λ) + φ, 0 exact estimates in Hölder norms for the solution of two nonlocal boundary value problems for parabolic equations with dependent coefficients are established.

  9. The Effects of 10 Communication Modes on the Behavior of Teams During Co-Operative Problem-Solving

    Science.gov (United States)

    Ochsman, Richard B.; Chapanis, Alphonse

    1974-01-01

    Sixty teams of two college students each solved credible "real world" problems co-operatively. Conversations were carried on in one of 10 modes of communication: (1) typewriting only, (2) handwriting only, (3) handwriting and typewriting, (4) typewriting and video, (5) handwriting and video, (6) voice only, (7) voice and typewriting, (8) voice and…

  10. Solvability conditions of the Cauchy problem for two-dimensional systems of linear functional differential equations with monotone operators

    Czech Academy of Sciences Publication Activity Database

    Šremr, Jiří

    2007-01-01

    Roč. 132, č. 3 (2007), s. 263-295 ISSN 0862-7959 R&D Projects: GA ČR GP201/04/P183 Institutional research plan: CEZ:AV0Z10190503 Keywords : system of functional differential equations with monotone operators * initial value problem * unique solvability Subject RIV: BA - General Mathematics

  11. Triple solutions for a Dirichlet boundary value problem involving a perturbed discrete p(k-Laplacian operator

    Directory of Open Access Journals (Sweden)

    Khaleghi Moghadam Mohsen

    2017-08-01

    Full Text Available Triple solutions are obtained for a discrete problem involving a nonlinearly perturbed one-dimensional p(k-Laplacian operator and satisfying Dirichlet boundary conditions. The methods for existence rely on a Ricceri-local minimum theorem for differentiable functionals. Several examples are included to illustrate the main results.

  12. Generating breakthrough new product ideas feeding the innovation funnel

    CERN Document Server

    Cooper, Robert

    2007-01-01

    Senior executives are experiencing a shortage of game-changing ideas that drive growth. This book explains how to feed the innovation funnel with a steady stream of breakthrough new product ideas, providing numerous examples of the methods, approaches and techniques used by leading companies such as Motorola and Procter & Gamble. Learn more about the impact you can make by leveraging an innovation strategy, voice-of-customer research, external ideas via open innovation, employees? creative talent and fundamental research. Establish a proactive Discovery Stage that focuses on the drivers of innovation performance to transform your organization into an innovation machine.

  13. Tsetse Fly Genome Breakthrough Brings Hope for African Farmers

    International Nuclear Information System (INIS)

    2014-01-01

    Scientists have cracked the genetic code of the bloodsucking tsetse fly, prompting hope that the breakthrough will help future efforts to control one of the most devastating livestock diseases in sub-Saharan Africa spread by the insect. The tsetse genome was sequenced and annotated during a 10-year international collaborative effort that involved the Insect Pest Control Laboratory run jointly by the United Nations Food and Agriculture Organization (FAO) and the International Atomic Energy Agency (IAEA) in Vienna. The achievement allows scientists to better study the fly's genes and their functions, knowledge that should open the door for researching ways to control the insect

  14. Mini-columns for Conducting Breakthrough Experiments. Design and Construction

    Energy Technology Data Exchange (ETDEWEB)

    Dittrich, Timothy M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Reimus, Paul William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ware, Stuart Douglas [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-06-11

    Experiments with moderately and strongly sorbing radionuclides (i.e., U, Cs, Am) have shown that sorption between experimental solutions and traditional column materials must be accounted for to accurately determine stationary phase or porous media sorption properties (i.e., sorption site density, sorption site reaction rate coefficients, and partition coefficients or Kd values). This report details the materials and construction of mini-columns for use in breakthrough columns to allow for accurate measurement and modeling of sorption parameters. Material selection, construction techniques, wet packing of columns, tubing connections, and lessons learned are addressed.

  15. Breakthrough indicator for aromatic VOCs using needle trap samplers for activated carbon adsorbent.

    Science.gov (United States)

    Cheng, Wen-Hsi; Jiang, Jia-Rong; Huang, Yi-Ning; Huang, Shiun-Chian; Yu, Yan-Pin

    2012-08-01

    Internal circulation cabinets equipped with granular activated carbon (GAC) for adsorbing volatile organic compounds (VOCs) are widely used to store bottles containing organic solvents in universities, colleges, and hospital laboratories throughout Taiwan. This work evaluates the VOC adsorption capacities of GAC using various adsorption times for gas stream mixtures of 100 ppm toluene and 100 ppm o-xylene. Additionally, needle trap sampling (NTS) technology was used to indicate the time for renewing the GAC to avoid VOC breakthrough from adsorbents. Experimental results demonstrate that the proposed models can linearly express toluene and o-xylene adsorption capacities as the natural logarithm of adsorption time (ln(t)) and can accurately simulate the equilibrium adsorption capacities (Qe, g VOCs/g GAC) for gaseous toluene and o-xylene. The NTS, packed with 60-80 mesh divinylbenzene (DVB) particles, was compared in terms of extraction efficiency by simultaneously using the 75-microm Carboxen/polydimethylsiloxane-solid-phase microextraction (Carboxen/PDMS-SPME) fiber for time-weighted average (TWA) sampling, and experimental results indicated that the packed DVB-NTS achieved higher toluene extraction rates. Additionally, the NTS installed in the outlet air stream for adsorbing toluene and o-xylene exhausted through GAC accurately indicated toluene and o-xylene breakthrough times of 4700-5000 min. The GAC-NTS operational instructions to indicate the replacing time of adsorbent in the internal circulation cabinets are also included in this paper.

  16. Layer potentials and boundary-value problems for second order elliptic operators with data in Besov spaces

    CERN Document Server

    Barton, Ariel

    2016-01-01

    This monograph presents a comprehensive treatment of second order divergence form elliptic operators with bounded measurable t-independent coefficients in spaces of fractional smoothness, in Besov and weighted L^p classes. The authors establish: (1) Mapping properties for the double and single layer potentials, as well as the Newton potential; (2) Extrapolation-type solvability results: the fact that solvability of the Dirichlet or Neumann boundary value problem at any given L^p space automatically assures their solvability in an extended range of Besov spaces; (3) Well-posedness for the non-homogeneous boundary value problems. In particular, the authors prove well-posedness of the non-homogeneous Dirichlet problem with data in Besov spaces for operators with real, not necessarily symmetric, coefficients.

  17. Reactor oscillator project - Theoretical study; operation problems; choice of the ionization chamber

    International Nuclear Information System (INIS)

    Lolic, B.; Markovic, V.

    1961-01-01

    Theoretical study of the reactor operator covers methods of the danger coefficient and the method based on measuring the phase angle. Operation with the reactor oscillator describes measurement of the cross section and resonance integral, measurement of the fissionable materials properties, measurement of impurities in the graphite sample. A separate chapter is devoted to the choice of the appropriate ionization chamber

  18. Study of operating procedures in nuclear power plants: Practices and problems

    International Nuclear Information System (INIS)

    Morgenstern, M.H.; Barnes, V.E.; McGuire, M.V.; Radford, L.R.; Wheeler, W.A.

    1987-02-01

    This report describes the project activities, findings, and recommendations of a project entitled ''Program Plan for Assessing and Upgrading Operating Procedures for Nuclear Power Plants.'' The project was performed by the Pacific Northwest Laboratory and Battelle Human Affairs Research Centers for the Division of Human Factors Technology, Office of Nuclear Reactor Regulation, US Nuclear Regulatory Commission (NRC). The project team analyzed and evaluated samples of normal and abnormal operating procedures from 31 commercial nuclear power plant sites operating in the United States. The project team also visited nine nuclear power plants in the United States to obtain information on the development, use, and control of operating procedures. A peer review group was convened to advise the project team on the conduct of the project and to review and comment on the project report. The report contains findings on the usability of operating procedures and on practices concerning the development, use, an control of operating procedures in nuclear power plants. The report includes recommendations to the NRC on the need to upgrade the quality of operating procedures. The report also discusses an approach to a program plan to assess and upgrade operating procedures

  19. Problems with Cash and Other Non-Operating Assets Value in the Process of Valuing Company

    Directory of Open Access Journals (Sweden)

    Piotr Szczepankowski

    2007-12-01

    Full Text Available In economic practice the process of valuing enterprises is based on potential earnings from companies operating assets ñ operating fixed assets and operating working capital. Cash and other non-operating assets (mainly financial are treated as unproductive, non-income assets. Eventually, in process of pricing their current, accounting value is added to income value of enterprise or cash is treated as source for quick covering the debts of firm, what of course indirectly improve for better value of equity (the lower financial risk. Not taking into account the profitable influence of cash value and other non-operating assets can negatively affect on result of final value of enterprise, reducing it. In the article two alternative approaches (separate and inclusive of cash value is presented. Also main determinants of estimating value of cash are described as well as potential threats of its valuation.

  20. Plant Operations. OSHA on Campus: Campus Safety Officers Discuss Problems and Potentials

    Science.gov (United States)

    Kuchta, Joseph F.; And Others

    1973-01-01

    The Occupation Safety and Health Act (OSHA) has presented campus safety officers with new problems, but it is also offering them new potentials, which were explored at the recent national conference on Campus Security. (Editor)

  1. How are things adding up? Neural differences between arithmetic operations are due to general problem solving strategies.

    Science.gov (United States)

    Tschentscher, Nadja; Hauk, Olaf

    2014-05-15

    A number of previous studies have interpreted differences in brain activation between arithmetic operation types (e.g. addition and multiplication) as evidence in favor of distinct cortical representations, processes or neural systems. It is still not clear how differences in general task complexity contribute to these neural differences. Here, we used a mental arithmetic paradigm to disentangle brain areas related to general problem solving from those involved in operation type specific processes (addition versus multiplication). We orthogonally varied operation type and complexity. Importantly, complexity was defined not only based on surface criteria (for example number size), but also on the basis of individual participants' strategy ratings, which were validated in a detailed behavioral analysis. We replicated previously reported operation type effects in our analyses based on surface criteria. However, these effects vanished when controlling for individual strategies. Instead, procedural strategies contrasted with memory retrieval reliably activated fronto-parietal and motor regions, while retrieval strategies activated parietal cortices. This challenges views that operation types rely on partially different neural systems, and suggests that previously reported differences between operation types may have emerged due to invalid measures of complexity. We conclude that mental arithmetic is a powerful paradigm to study brain networks of abstract problem solving, as long as individual participants' strategies are taken into account. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Problems with numerical techniques: Application to mid-loop operation transients

    Energy Technology Data Exchange (ETDEWEB)

    Bryce, W.M.; Lillington, J.N.

    1997-07-01

    There has been an increasing need to consider accidents at shutdown which have been shown in some PSAs to provide a significant contribution to overall risk. In the UK experience has been gained at three levels: (1) Assessment of codes against experiments; (2) Plant studies specifically for Sizewell B; and (3) Detailed review of modelling to support the plant studies for Sizewell B. The work has largely been carried out using various versions of RELAP5 and SCDAP/RELAP5. The paper details some of the problems that have needed to be addressed. It is believed by the authors that these kinds of problems are probably generic to most of the present generation system thermal-hydraulic codes for the conditions present in mid-loop transients. Thus as far as possible these problems and solutions are proposed in generic terms. The areas addressed include: condensables at low pressure, poor time step calculation detection, water packing, inadequate physical modelling, numerical heat transfer and mass errors. In general single code modifications have been proposed to solve the problems. These have been very much concerned with means of improving existing models rather than by formulating a completely new approach. They have been produced after a particular problem has arisen. Thus, and this has been borne out in practice, the danger is that when new transients are attempted, new problems arise which then also require patching.

  3. The next breakthrough in phonon-mediated superconductivity

    International Nuclear Information System (INIS)

    Pickett, W.E.

    2008-01-01

    If history teaches us anything, it is that the next breakthrough in superconductivity will not be the result of surveying the history of past breakthroughs, as they have almost always been a matter of serendipity resulting from undirected exploration into new materials. Still, there is reason to reflect on recent advances, work toward higher T c of even an incremental nature, and recognize that it is important to explore avenues currently believed to be unpromising even as we attempt to be rational. In this paper we look at two remarkable new unusually high temperature superconductors (UHTS), MgB 2 with T c = 40 K and (in less detail) high pressure Li with T c = 20 K, with the aim of reducing their unexpected achievements to a simple and clear understanding. We also consider briefly other UHTS systems that provide still unresolved puzzles; these materials include mostly layered structures, and several with strongly bonded C-C or B-C substructures. What may be possible in phonon-coupled superconductivity is reconsidered in the light of the discussion

  4. Turning Regenerative Medicine Breakthrough Ideas and Innovations into Commercial Products.

    Science.gov (United States)

    Bayon, Yves; Vertès, Alain A; Ronfard, Vincent; Culme-Seymour, Emily; Mason, Chris; Stroemer, Paul; Najimi, Mustapha; Sokal, Etienne; Wilson, Clayton; Barone, Joe; Aras, Rahul; Chiesi, Andrea

    2015-12-01

    The TERMIS-Europe (EU) Industry committee intended to address the two main critical issues in the clinical/commercial translation of Advanced Therapeutic Medicine Products (ATMP): (1) entrepreneurial exploitation of breakthrough ideas and innovations, and (2) regulatory market approval. Since January 2012, more than 12,000 publications related to regenerative medicine and tissue engineering have been accepted for publications, reflecting the intense academic research activity in this field. The TERMIS-EU 2014 Industry Symposium provided a reflection on the management of innovation and technological breakthroughs in biotechnology first proposed to contextualize the key development milestones and constraints of allocation of financial resources, in the development life-cycle of radical innovation projects. This was illustrated with the biofuels story, sharing similarities with regenerative medicine. The transition was then ensured by an overview of the key identified challenges facing the commercialization of cell therapy products as ATMP examples. Real cases and testimonies were then provided by a palette of medical technologies and regenerative medicine companies from their commercial development of cell and gene therapy products. Although the commercial development of ATMP is still at the proof-of-concept stage due to technology risks, changing policies, changing markets, and management changes, the sector is highly dynamic with a number of explored therapeutic approaches, developed by using a large diversity of business models, both proposed by the experience, pitfalls, and successes of regenerative medicine pioneers, and adapted to the constraint resource allocation and environment in radical innovation projects.

  5. A Hybrid Genetic Algorithm with a Knowledge-Based Operator for Solving the Job Shop Scheduling Problems

    Directory of Open Access Journals (Sweden)

    Hamed Piroozfard

    2016-01-01

    Full Text Available Scheduling is considered as an important topic in production management and combinatorial optimization in which it ubiquitously exists in most of the real-world applications. The attempts of finding optimal or near optimal solutions for the job shop scheduling problems are deemed important, because they are characterized as highly complex and NP-hard problems. This paper describes the development of a hybrid genetic algorithm for solving the nonpreemptive job shop scheduling problems with the objective of minimizing makespan. In order to solve the presented problem more effectively, an operation-based representation was used to enable the construction of feasible schedules. In addition, a new knowledge-based operator was designed based on the problem’s characteristics in order to use machines’ idle times to improve the solution quality, and it was developed in the context of function evaluation. A machine based precedence preserving order-based crossover was proposed to generate the offspring. Furthermore, a simulated annealing based neighborhood search technique was used to improve the local exploitation ability of the algorithm and to increase its population diversity. In order to prove the efficiency and effectiveness of the proposed algorithm, numerous benchmarked instances were collected from the Operations Research Library. Computational results of the proposed hybrid genetic algorithm demonstrate its effectiveness.

  6. Eigenvalue-eigenfunction problem for Steklov's smoothing operator and differential-difference equations of mixed type

    Directory of Open Access Journals (Sweden)

    Serguei I. Iakovlev

    2013-01-01

    Full Text Available It is shown that any \\(\\mu \\in \\mathbb{C}\\ is an infinite multiplicity eigenvalue of the Steklov smoothing operator \\(S_h\\ acting on the space \\(L^1_{loc}(\\mathbb{R}\\. For \\(\\mu \

  7. Operant Conditioning Principles in the Treatment of Learning and Behavior Problems with Delinquent Boys

    Science.gov (United States)

    Bednar, Richard L.; And Others

    1970-01-01

    This study on operant conditioning showed that both groups showed significant improvement in reading skills from pretest to posttest, but that the reinforced group showed significantly more improvement than the nonreinforced group. (Author)

  8. National Security Cutter: Enhanced Oversight Needed to Ensure Problems Discovered during Testing and Operations Are Addressed

    Science.gov (United States)

    2016-01-01

    May Lead to NSCs and Future DHS Assets Deploying without Having Demonstrated Full Capabilities 22 Performance Issues Discovered Outside of IOT &E...Examples of National Security Cutter Critical Operational Issues and Key Performance Parameters 10 Table 3: National Security Cutter Major...Cutter IOT &E Initial Operational Test and Evaluation KPP Key Performance Parameter LRI-II Long-Range Interceptor II NSC National Security Cutter

  9. Applications of elliptic operator theory to the isotropic interior transmission eigenvalue problem

    Science.gov (United States)

    Lakshtanov, E.; Vainberg, B.

    2013-10-01

    The paper concerns the isotropic interior transmission eigenvalue (ITE) problem. This problem is not elliptic, but we show that, using the Dirichlet-to-Neumann map, it can be reduced to an elliptic one. This leads to the discreteness of the spectrum as well as to certain results on a possible location of the transmission eigenvalues. If the index of refraction \\sqrt{n(x)} is real, then we obtain a result on the existence of infinitely many positive ITEs and the Weyl-type lower bound on its counting function. All the results are obtained under the assumption that n(x) - 1 does not vanish at the boundary of the obstacle or it vanishes identically, but its normal derivative does not vanish at the boundary. We consider the classical transmission problem as well as the case when the inhomogeneous medium contains an obstacle. Some results on the discreteness and localization of the spectrum are obtained for complex valued n(x).

  10. Marketization of Collective-owned Rural Land: A Breakthrough in Shenzhen, China

    Directory of Open Access Journals (Sweden)

    Yonghua Zou

    2014-12-01

    Full Text Available This study focuses on analyzing the ongoing land policy reform that allows collective-owned rural land transactions in the open market in Shenzhen, China. Employing a case study method, we investigate this land policy evolution through description and contextual analysis. We argue that the existing dual-track land administration system, within which the state administers market transactions, has contributed to numerous social problems, such as urban land scarcity, inefficiency of land resource allocation, and exacerbated social injustice. Following the recent actions of the central government, a collective-owned rural land parcel in Shenzhen was officially transferred in November 2013, an action viewed as a landmark step in reforming the current dual-track land system. Though the generalization of Shenzhen’s experiment nationwide faces significant barriers, Shenzhen’s breakthrough in liberalization of the rural land market indicates that China is moving toward a potential new round of land policy revolution.

  11. RISK DECREASE PROBLEM WITH MAKING ERRORS IN ACTIVITY OF OPERATORS DEALING WITH AUTOMATIC CONTROL SYSTEMS OF GAS-DISTRIBUTION STATIONS

    Directory of Open Access Journals (Sweden)

    V. V. Egorov

    2011-01-01

    Full Text Available The paper contains an analysis of specific features pertaining to the activity of operators dealing with automatic control systems of gas-distribution stations. The professional operator’s activity is presented in the form of the developed data model. Possible conceptual approaches to the research are analyzed in the paper. The paper describes an author’s approach to studying a risk decrease problem in the activity of operators on the basis of the analytical research results. Technology for obtaining  research results is cited in the paper. 

  12. Operational problems with radiation survey meters - The University and Accelerator perspectives

    International Nuclear Information System (INIS)

    McCall, R.C.

    1984-06-01

    This article describes problems encountered with commercial survey meters. The desired qualities of such instruments for use around accelerators are listed. Attempts to meet the accelerator monitoring needs by modifying commercial instruments and by in-house research and development are described

  13. Abolishing and Establishing Operation Analyses of Social Attention as Positive Reinforcement for Problem Behavior

    Science.gov (United States)

    McGinnis, Molly A.; Houchins-Juarez, Nealetta; McDaniel, Jill L.; Kennedy, Craig H.

    2010-01-01

    Three participants whose problem behavior was maintained by contingent attention were exposed to 45-min presessions in which attention was withheld, provided on a fixed-time (FT) 15-s schedule, or provided on an FT 120-s schedule. Following each presession, participants were then tested in a 15-min session similar to the social attention condition…

  14. Problems and Pitfalls in Setting Up and Operating an Online Information Service.

    Science.gov (United States)

    Moureau, Magdeleine L.

    1978-01-01

    Physical, economic, technical, and social constraints are analyzed in the case of the online vendor, and each component in the chain is considered separately. The user's problems are analyzed from the viewpoint of both the intermediary and the end user, and the effect of the changeover to a new system is considered. (Author)

  15. Tactic-operational problems of soldiers, civilians and environmental protection against contamination

    International Nuclear Information System (INIS)

    Krauze, M.

    1994-01-01

    The military problems connected with the probable use in warfare the chemical and nuclear weapon have been discussed. The concept of soldiers, civilians and environmental protection against the chemical and radiological contamination has been presented from the view point of military tactics

  16. Female and male communication in co-operative problem solving in high school science

    NARCIS (Netherlands)

    Harskamp, Egbert; Dhig, Ning; Tremante, A; Welsch, F; Malpica, F

    2007-01-01

    Empirical evidence is presented that males working in mixed-gender dyads on science problems do better than their female partners. This is not the case when males and females work in same gender dyads. There is a difference in communication style in mixed gender dyads in comparison with same gender

  17. An Improved SPEA2 Algorithm with Adaptive Selection of Evolutionary Operators Scheme for Multiobjective Optimization Problems

    Directory of Open Access Journals (Sweden)

    Fuqing Zhao

    2016-01-01

    Full Text Available A fixed evolutionary mechanism is usually adopted in the multiobjective evolutionary algorithms and their operators are static during the evolutionary process, which causes the algorithm not to fully exploit the search space and is easy to trap in local optima. In this paper, a SPEA2 algorithm which is based on adaptive selection evolution operators (AOSPEA is proposed. The proposed algorithm can adaptively select simulated binary crossover, polynomial mutation, and differential evolution operator during the evolutionary process according to their contribution to the external archive. Meanwhile, the convergence performance of the proposed algorithm is analyzed with Markov chain. Simulation results on the standard benchmark functions reveal that the performance of the proposed algorithm outperforms the other classical multiobjective evolutionary algorithms.

  18. Approaches for Accommodating Demand Response in Operational Problems and Assessing its Value

    DEFF Research Database (Denmark)

    O'Connell, Niamh

    . However, before the necessary investments can be made to establish and operate this novel resource, its value must be determined. As with all current power system resources, if distributed demand response is deployed on a large scale it will be required to interface with the power system and market...... investments will be made to establish and operate the resource. A positive commercial assessment will signal to investors that the resource can offer a return on their investment, and that it can thrive in a competitive environment. We consider both the social welfare and commercial value of demand response......This thesis deals with the development of operational models of demand response and the evaluation of this novel resource within existing frameworks for power system dispatch and market clearing. Increasing shares of power generation from variable renewable sources, and climate change policies...

  19. Experimental applications of an expert system to operator problem solving in process control

    International Nuclear Information System (INIS)

    Nelson, W.R.; Jenkins, J.P.

    1985-01-01

    The United States Nuclear Regulatory Commission (USNRC) has sponsored a program to assess the effectiveness of expert systems for nuclear reactor operators. The project has included two human factors experimental evaluations of the Response Tree expert system, a prototype expert system for helping nuclear reactor operators respond to emergency conditions. This paper discusses the Response Tree expert system, the experiments which have been performed to test its effectiveness, and the results of the experiments. Reference is made to the accident at TMI. 12 refs

  20. Scientific breakthroughs necessary for the commercial success of renewable energy (Invited)

    Science.gov (United States)

    Sharp, J.

    2010-12-01

    In recent years the wind energy industry has grown at an unprecedented rate, and in certain regions has attained significant penetration into the power infrastructure. This growth has been both a result of, and a precursor to, significant advances in the science and business of wind energy. But as a result of this growth and increasing penetration, further advances and breakthroughs will become increasingly important. These advances will be required in a number of different aspects of wind energy, including: resource assessment, operations and performance analysis, forecasting, and the impacts of increased wind energy development. Resource assessment has benefited from the development of tools specifically designed for this purpose. Despite this, the atmosphere is often portrayed in an extremely simplified manner by these tools. New methodologies should rely upon more sophisticated application of the physics of fluid flows. There will need to be an increasing reliance and acceptance of improved measurement techniques (remote sensing, volume rather than point measurements, etc), and more sophisticated and higher-resolution numerical methods for micrositing. The goals of resource assessment will have to include a better understanding of the variability and forecastability of potential sites. Operational and performance analysis are vital to quantifying how well all aspects of the business are being carried out. Operational wind farms generate large amounts of meteorological and mechanical data. Data mining and detailed analysis of this data has proven to be invaluable to shed light upon poorly understood aspects of the science and industry. Future analysis will need to be even more rigorous and creative. Worthy topics of study include the impact of turbine wakes upon downstream turbine performance, how to utilize operational data to improve resource assessment and forecasting, and what the impacts of large-scale wind energy development might be. Forecasting is an

  1. Supply chain optimization: a practitioner's perspective on the next logistics breakthrough.

    Science.gov (United States)

    Schlegel, G L

    2000-08-01

    The objective of this paper is to profile a practitioner's perspective on supply chain optimization and highlight the critical elements of this potential new logistics breakthrough idea. The introduction will briefly describe the existing distribution network, and business environment. This will include operational statistics, manufacturing software, and hardware configurations. The first segment will cover the critical success factors or foundations elements that are prerequisites for success. The second segment will give you a glimpse of a "working game plan" for successful migration to supply chain optimization. The final segment will briefly profile "bottom-line" benefits to be derived from the use of supply chain optimization as a strategy, tactical tool, and competitive advantage.

  2. Concept Specification by PRECIS Role Operators: Some Technical Problems with Social Science and Humanities Literature.

    Science.gov (United States)

    Mahapatra, M.; Biswas, S. C.

    1985-01-01

    Two hundred journal articles related to fields of taxation, genetic psychology, and Shakespearean drama published from 1970-1980 were analyzed and PRECIS input strings were drawn. Occasions when input string and index entries looked incomplete and unexpressive after losing context of document are provided with solutions. Role operator schema is…

  3. Capital and Operating Cost of Small Arsenic Removal System and their Most Frequent Maintenance Problems

    Science.gov (United States)

    This presentation will first summarize the capital and operating cost of treatment systems by type and size of the systems. The treatment systems include adsorptive media (AM) systems, iron removal (IR), coagulation/filtration (CF), ion exchange (IX) systems, and point-of-use rev...

  4. Operational problems associated with the use of particulate emission control for MACT compliance applications

    International Nuclear Information System (INIS)

    Compton, J.A.

    1992-03-01

    Tests of high-efficiency particulate air filters were requested following catastrophic failure of a filter by hydrogen fluoride gas from improper operation in a production line. Operational lives in hydrogen fluoride environments of high-efficiency particulate air filters were determined in statistically designed experiments for three variable. The variables studied were hydrogen fluoride gas concentration, water vapor concentration, and wind speed through a hydrogen fluoride-resistant filter medium. The program was terminated after 11 of the 16 runs were completed. The 11 runs indicate no statistically significant effect by any of the three variables. Two additional runs were completed with non-hydrogen fluoride-resistant filters and shorter operating lives were found. The tests determined that the interim operational safety limits imposed after the original filter failure were adequate. More frequent testing of the filters in the associated production line was recommended for assuring filter integrity. The tests also showed that filter efficiency loss is relatively slow at first, but accelerates

  5. Ensemble Kalman Filtering with Residual Nudging: An Extension to State Estimation Problems with Nonlinear Observation Operators

    KAUST Repository

    Luo, Xiaodong; Hoteit, Ibrahim

    2014-01-01

    -space-based strategy, called residual nudging, to improve the stability of the EnKF when dealing with linear observation operators. The main idea behind residual nudging is to monitor and, if necessary, adjust the distances (misfits) between the real observations

  6. Facing operational problems in a biodigester in Yuvientsa - Amazonian region of Ecuador

    Energy Technology Data Exchange (ETDEWEB)

    Aragundy, J.

    2007-07-01

    Yuvientsa is a Shuar indigenous community located in the Morona Santiago Province in the southwestern part of the Amazonian region of Ecuador. Two types of alternative energies have being implemented in Yuvientsa to satisfy people's needs. Solar panels provide electricity to the community. A biodigester to treat the school lavatories' brown-water (fecal water) and to provide gas for cooking to the communal kitchen was built as well. During the operational phase the biodigester faced some difficulties as: being perforated by people of the community as started inflating, being fumigated against malaria, and not having enough organic matter to produce biogas. As a result in this time the biodigester did not operate satisfactorily and the community did not believe that it could work and produce biogas. A biodigester should not be built without an awareness campaign or showing a direct benefit to the community that ensures its adequate operation and maintenance. Before constructing the reactor the organic matter source to operate the biodigester should be clearly identified and its amount should be enough. (orig.)

  7. Studying the effects of operators' problem solving behaviour when using a diagnostic expert system developed for the nuclear industry

    International Nuclear Information System (INIS)

    Holmstroem, C.B.O.; Volden, F.S.; Endestad, T.

    1992-01-01

    This paper describes an experiment with the purpose to also illustrate and discuss some of the methodological problems when empirically studying problem solving. The experiment which was the second in a series, conducted at the OECD Halden Reactor Project, aimed to assess the effect on nuclear power plant operators diagnostic behaviour when using a rule-based diagnostic expert system. The rule-based expert system used in the experiment is called DISKET (Diagnosis System Using Knowledge Engineering Technique) and was originally developed by the Japan Atomic Energy Research Institute (JAERI). The experiment was performed in the Halden man-machine laboratory using a full scope pressurized water reactor simulator. Existing data collection methods and experimental design principles includes possibilities but also limitations. This is discussed and experiences are presented. Operator performance in terms of quality of diagnosis is improved by the use of DISKET. The use of the DISKET system also influences operators problem solving behaviour. The main difference between the two experimental conditions can be characterized as while the DISKET users during the diagnosis process are following a strategy which is direct and narrowed, the non-DISKET users are using a much broader and less focused search when trying to diagnose a disturbance. (author)

  8. How to revive breakthrough innovation in the pharmaceutical industry.

    Science.gov (United States)

    Munos, Bernard H; Chin, William W

    2011-06-29

    Over the past 20 years, pharmaceutical companies have implemented conservative management practices to improve the predictability of therapeutics discovery and success rates of drug candidates. This approach has often yielded compounds that are only marginally better than existing therapies, yet require larger, longer, and more complex trials. To fund them, companies have shifted resources away from drug discovery to late clinical development; this has hurt innovation and amplified the crisis brought by the expiration of patents on many best-selling drugs. Here, we argue that more breakthrough therapeutics will reach patients only if the industry ceases to pursue "safe" incremental innovation, re-engages in high-risk discovery research, and adopts collaborative innovation models that allow sharing of knowledge and costs among collaborators.

  9. Energy problems of developing countries and the development co-operation

    Energy Technology Data Exchange (ETDEWEB)

    Mutanen, K; Sahrman, K

    1984-12-15

    The technology, economy and problems of energy sector in developing countries are presented as well as the possibilities of solving energy problems, with special emphasis on how to adapt Finnish energy know-how to the conditions existing in the developing countries. The population in the developing countries has grown explosively. The worst energy problem due to this growth is the shortage of firewood. The fact that wood is used for burning is one reason for the formation of deserts. Today already about one hundred million people in developing countries suffer from shortage of energy. In the following 20-30 years it will threaten already about one billion people. Poverty in the developing countries prevents the use of fossil fuels like oil. It is likely that the developing countries already in the coming decades will have to start to use new and renewable sources of energy, like these are solar and wind energy as well as hydroelectric power. The efficiency of burning fire wood should rapidly be improved. On the other hand reforestration should be increased. Also fossil fuels are needed before new sources of energy can be used. All over the world there has been interest in the energy problems of the developing countries. The World Bank and other financing bodies are increasing their financial aid for different kinds of energy projects. The Finnish development aid is primarily bilateral and concentrated in certain countries. In the 1980's the energy sector will be one of the main fields in our development aid, at the same time as the portion of our development aid from gross national income is increasing.

  10. Operation of a low-level waste disposal facility and how to prevent problems in future facilities

    International Nuclear Information System (INIS)

    Di Sibio, R.

    1985-01-01

    Operation of a low-level waste facility is an ever increasing problem nationally, and specifically one that could grow to crisis proportion in Pennsylvania. There have been, nevertheless, a variety of changes over the years in the management of low level radioactive waste, particularly with regard to disposal facilities that can avert a crisis condition. A number of companies have been organized thru possible a broad range of services to the nuclear industry, including those that emphasize solidification of waste materials, engineering services, waste management, and transportation to disposal sites across the United States. This paper addresses one particular site and the problems which evolved at that site from an environmental perspective. It is important that it is clearly understood that, although these problems are resolvable, the lessons learned here are critical for the prevention of problems at future facilities. The focus of this paper is on the Maxey Flats, Kentucky disposal facility which was closed in 1977. It must be understood that the regulations for siting, management, burial techniques, waste classification, and the overall management of disposal sites were limited when this facility was in operation

  11. Incremental artificial bee colony with local search to economic dispatch problem with ramp rate limits and prohibited operating zones

    International Nuclear Information System (INIS)

    Özyön, Serdar; Aydin, Doğan

    2013-01-01

    Highlights: ► Prohibited operating zone economic dispatch problem has been solved by IABC-LS. ► The losses used in the solution of the problem have been computed by B-loss matrix. ► IABC-LS method has been applied to three test systems in literature. ► The values obtained by IABC and IABC-LS are better than the results in literature. - Abstract: In this study, prohibited operating zone economic power dispatch problem which considers ramp rate limit, has been solved by incremental artificial bee colony algorithm (IABC) and incremental artificial bee colony algorithm with local search (IABC-LS) methods. The transmission line losses used in the solution of the problem have been computed by B-loss matrix. IABC, IABC-LS methods have been applied to three different test systems in literature which consist of 6, 15 and 40 generators. The attained optimum solution values have been compared with the optimum results in literature and have been discussed.

  12. Reliability problems in the recirculated cooling water system at Cernavoda NPP and corrective maintenance operations adopted

    International Nuclear Information System (INIS)

    Bucur, Ionel; Metes, Mircea

    2002-01-01

    Between February 18 and March 5, 2002 the Unit 1 of Cernavoda NPP was shutdown in an un-planned outage necessary to repair a crack on the piping of the Recirculated Cooling Water System. The large pipe diameter and the requirement of maintaining the system in operation during the outage, imposed a special technology for fixing the leak (isolation of the line with ice plugs). The paper presents information about the performed repair work. After repair operations the failed duct was checked by non-destructive methods and the results were submitted and approved by regulation authorities. The repair was considered successfully completed and the Unit restarted on March 5, 2002 at 0.57 am when the electric generator was switched on in parallel to the national electric power system. (authors)

  13. A formulation to analyze system-of-systems problems: A case study of airport metroplex operations

    Science.gov (United States)

    Ayyalasomayajula, Sricharan Kishore

    A system-of-systems (SoS) can be described as a collection of multiple, heterogeneous, distributed, independent components interacting to achieve a range of objectives. A generic formulation was developed to model component interactions in an SoS to understand their influence on overall SoS performance. The formulation employs a lexicon to aggregate components into hierarchical interaction networks and understand how their topological properties affect the performance of the aggregations. Overall SoS performance is evaluated by monitoring the changes in stakeholder profitability due to changes in component interactions. The formulation was applied to a case study in air transportation focusing on operations at airport metroplexes. Metroplexes are geographical regions with two or more airports in close proximity to one another. The case study explored how metroplex airports interact with one another, what dependencies drive these interactions, and how these dependencies affect metroplex throughput and capacity. Metrics were developed to quantify runway dependencies at a metroplex and were correlated with its throughput and capacity. Operations at the New York/New Jersey metroplex (NYNJ) airports were simulated to explore the feasibility of operating very large aircraft (VLA), such as the Airbus A380, as a delay-mitigation strategy at these airports. The proposed formulation was employed to analyze the impact of this strategy on different stakeholders in the national air transportation system (ATS), such as airlines and airports. The analysis results and their implications were used to compare the pros and cons of operating VLAs at NYNJ from the perspectives of airline profitability, and flight delays at NYNJ and across the ATS.

  14. A Bankruptcy Problem Approach to Load-shedding in Multiagent-based Microgrid Operation

    OpenAIRE

    Kim, Hak-Man; Kinoshita, Tetsuo; Lim, Yujin; Kim, Tai-Hoon

    2010-01-01

    A microgrid is composed of distributed power generation systems (DGs), distributed energy storage devices (DSs), and loads. To maintain a specific frequency in the islanded mode as an important requirement,  the control of DGs’ output and charge action of DSs are used in supply surplus conditions and load-shedding and discharge action of DSs are used in supply shortage conditions. Recently, multiagent systems for autonomous microgrid operation have been studied. Especially, load-shedding, whi...

  15. Some problems of evaluating environmental impacts of nuclear power installation building and operation

    International Nuclear Information System (INIS)

    Uvirova, E.

    1984-01-01

    The impacts of the construction and operation of a nuclear power installation on the natural environment is discussed, namely on changes in the landscape profile, in the structure of settlement and large-scale agricultural production, the requisition of agricultural land, changes in transport systems, etc., as well as approaches to the evaluation of these environmental impacts with the aim of preserving the optimal state of inter-relations between man and the natural environment. (author)

  16. Operational Problems Associated with Head-Up Displays during Instrument Flight.

    Science.gov (United States)

    1980-10-01

    Force project engineers were Major Michael F. Rundle and Mr. William L. Welde . 41 4 TABLE OF CONTENTS Page ABBREVIATIONS...of Automotive Engineers SETP Society of Experimental Test Pilots SI Solid Instruments SNPL Syndicat National des Pilotes des Lignes (French ALPA) TACAN...Factors Relevent to Jet Upsets ," Lessons with Emphasis on Flight Mechanics from Operating Experience, Incidents, and Accidents, AGARD CP-76, 1971 153 J

  17. Consequences and potential problems of operating room outbursts and temper tantrums by surgeons

    OpenAIRE

    Jacobs, George B.; Wille, Rosanne L.

    2012-01-01

    Background: Anecdotal tales of colorful temper tantrums and outbursts by surgeons directed at operating room nurses and at times other health care providers, like residents and fellows, are part of the history of surgery and include not only verbal abuse but also instrument throwing and real harassment. Our Editor-in-Chief, Dr. Nancy Epstein, has made the literature review of “Are there truly any risks and consequences when spine surgeons mistreat their predominantly female OR nursing staff/c...

  18. CRITICAL FACTORS THAT LEAD TO GREEN BUILDING OPERATIONS AND MAINTENANCE PROBLEMS IN MALAYSIA

    OpenAIRE

    Izran Sarrazin MOHAMMAD; Nurul Nadiah ZAINOL; Shardy ABDULLAH; Neo Bee WOON; Nur Aqlima RAMLI

    2014-01-01

    The development of green buildings has become a trend in recent years in the effort to enhance the well-being of the community, environmental health, and life-cycle cost. However, many have argued that the complexities rendered by green buildings during the operational and maintenance phase often overshadow the benefits that can be gained through the development of green buildings. Several factors that lead to complexities in managing and maintaining green buildings have been highlighted by s...

  19. The measurement problem in quantum mechanics: approximation to the phenomenon of decoherence by operational identities

    International Nuclear Information System (INIS)

    Usera, J.I.

    1996-01-01

    An approach based on bits and pieces of standard wisdom plus and operational quantum mechanical identity deduced by the author is presented here in order to convey arguments concerning the quantum theory of measurement and which betray a flavor against completive claims for quantum mechanics. Special emphasis is put on the phenomenon of decoherence. This phenomenon (which is experimentally verifiable) finds natural room within the formalism while the wave function collapse (which is not) is precluded. (Author)

  20. Problems of rotator cuff re-tear cases. Examination of operative findings

    International Nuclear Information System (INIS)

    Ishitani, Eiichi; Matsuura, Komei; Shin, Kunichika; Kawamoto, Taisaku; Hosokawa, Akira

    2007-01-01

    High re-tear rate is reported after rotator cuff repair in large and massive tear cases. Previously, we reported that 15% of patients after rotator cuff repair showed re-tear in MRI findings. In this study, 116 consecutive rotator cuff repaired patients who had been operated arthroscopically since 2003 were evaluated for size, torn site, fixation methods, mobility, and tendon quality. In addition, rehabilitation methods and occupation after revision were also evaluated. There were four patients who underwent re-operation. Rotator cuff repairs by revision surgery failed mechanically due to two reasons: the main factor of failure was suture material breakage in three cases and the second was tendon pulling through sutures in one case. The lack of thread strength was suggested. In addition, it is important to pull cuff stump to greater tubercle without excessive tension. Of re-operated cases, three engaging in manual labor suffered large and massive tear. In two cases, premature return to manual labor suggested cause of re-tear. (author)

  1. Operating room scheduling and surgeon assignment problem under surgery durations uncertainty.

    Science.gov (United States)

    Liu, Hongwei; Zhang, Tianyi; Luo, Shuai; Xu, Dan

    2017-12-29

    Scientific management methods are urgently needed to balance the demand and supply of heath care services in Chinese hospitals. Operating theatre is the bottleneck and costliest department. Therefore, the surgery scheduling is crucial to hospital management. To increase the utilization and reduce the cost of operating theatre, and to improve surgeons' satisfaction in the meantime, a practical surgery scheduling which could assign the operating room (OR) and surgeon for the surgery and sequence surgeries in each OR was provided for hospital managers. Surgery durations were predicted by fitting the distributions. A two-step mixed integer programming model considering surgery duration uncertainty was proposed, and sample average approximation (SAA) method was applied to solve the model. Durations of various surgeries were log-normal distributed respectively. Numerical experiments showed the model and method could get good solutions with different sample sizes. Real-life constraints and duration uncertainty were considered in the study, and the model was also very applicable in practice. Average overtime of each OR was reducing and tending to be stable with the number of surgeons increasing, which is a discipline for OR management.

  2. The use of sewage sludge as additive to avoid operational problems at combustion of shredder residues

    International Nuclear Information System (INIS)

    Gyllenhammar, Marianne

    2010-01-01

    When shredder light fraction (SLF) from recovery of metal scrap is energy recovered it is usually mixed with more than 90% of other wastes. SLF is a fuel with high energy content but also with relatively high chlorine and metal content and could cause deposit and corrosion problems in incineration plants. Sewage sludge has previously been shown to reduce deposition and corrosion problems in combustion of alkali and chlorine containing biomass. In this work 20 % SLF (by energy content) has been combusted together with municipal solid waste and industrial wastes, with and without addition of 3 % (by energy content) sewage sludge. The initial fireside corrosion rate was then compared to the corrosion rate during combustion of the normal fuel mix, i.e. only municipal solid waste and industrial wastes. The tests were done at the 20 MW fluidized bed boiler of Lidkoping heat production plant. During the tests air-cooled corrosion and deposit probes were exposed for 24 hours. Deposit probes were placed at three different flue gas temperatures - in the combustion chamber, upstream and downstream the convection pass. The corrosion probes were placed upstream the convection pass and on the probes there were three different materials at three different water temperatures (280, 350 and 420 degree Celsius). The tests showed that sewage sludge could help avoiding deposition and corrosion problems when incinerating SLF. The amount of deposits was reduced and the content of the deposits was less corrosive when sewage sludge was added. The project was financed by Waste Refinery as a collaboration project between Stena Metall AB, Metso AB, High Temperature Corrosion Center at Chalmers University of Technology, SP Technical Research Institute of Sweden and Lidkopings Varmeverk. (author)

  3. 1/f and the Earthquake Problem: Scaling constraints that facilitate operational earthquake forecasting

    Science.gov (United States)

    yoder, M. R.; Rundle, J. B.; Turcotte, D. L.

    2012-12-01

    The difficulty of forecasting earthquakes can fundamentally be attributed to the self-similar, or "1/f", nature of seismic sequences. Specifically, the rate of occurrence of earthquakes is inversely proportional to their magnitude m, or more accurately to their scalar moment M. With respect to this "1/f problem," it can be argued that catalog selection (or equivalently, determining catalog constraints) constitutes the most significant challenge to seismicity based earthquake forecasting. Here, we address and introduce a potential solution to this most daunting problem. Specifically, we introduce a framework to constrain, or partition, an earthquake catalog (a study region) in order to resolve local seismicity. In particular, we combine Gutenberg-Richter (GR), rupture length, and Omori scaling with various empirical measurements to relate the size (spatial and temporal extents) of a study area (or bins within a study area) to the local earthquake magnitude potential - the magnitude of earthquake the region is expected to experience. From this, we introduce a new type of time dependent hazard map for which the tuning parameter space is nearly fully constrained. In a similar fashion, by combining various scaling relations and also by incorporating finite extents (rupture length, area, and duration) as constraints, we develop a method to estimate the Omori (temporal) and spatial aftershock decay parameters as a function of the parent earthquake's magnitude m. From this formulation, we develop an ETAS type model that overcomes many point-source limitations of contemporary ETAS. These models demonstrate promise with respect to earthquake forecasting applications. Moreover, the methods employed suggest a general framework whereby earthquake and other complex-system, 1/f type, problems can be constrained from scaling relations and finite extents.; Record-breaking hazard map of southern California, 2012-08-06. "Warm" colors indicate local acceleration (elevated hazard

  4. Demand and problems of computer-aided implementation of operating, emergency and quality assurance manuals

    International Nuclear Information System (INIS)

    Oppermann, W.; Rempe, W.; Boehme, P.

    1994-01-01

    Considerations and software solutions are presented to convert manuals for use in electronic data processing. It is demonstrated that a very consistent use of electronic data processing can contribute to reduce the probability of human failure in technical installations. However, the representation of information differs considerably from paper documentations, because the ergonomic possibilities of visualizing offered by data processing systems are used. In particular in nuclear engineering several questions and problems arise in this context which concern the structuring of the content of data processing documentations, and their verifiability by experts. (orig./DG) [de

  5. Ontario Hydro's operating experience with steam generators with specifics on Bruce A and Bruce B problems

    Energy Technology Data Exchange (ETDEWEB)

    Eatock, J W; Patterson, R W [Ontario Hydro, Toronto, ON (Canada); Dyck, R W [Ontario Hydro, Central Production Services Division, Toronto, ON (Canada)

    1991-04-01

    The performance of the steam generators in Ontario Hydro nuclear power stations is reviewed. This performance has generally been outstanding compared to world averages, with very low tube failure and plugging rates. Steam generator problems have made only minor contributions to Ontario Hydro nuclear station incapability factors. The mechanisms responsible for the the observed tube degradation and failures are described. The majority of the leaks have been due fatigue in the U-bend of the Bruce 'A' steam generators. There have been very few failures attributed to corrosion of the three tube materials used in Ontario Hydro steam generators. Recent performance has been deteriorating primarily due to deposit accumulation in the steam generators. Plugging of the broached holes in the upper support plates at Bruce 'A' has caused some derating of two units. Increases have been observed in the primary heat transport system reactor inlet temperature of several units. These increases may be attributed to steam generator tube surface fouling. In addition, several units have accumulated deep, hard sludge piles on the tube sheet, although little damage been observed. Recently some fretting of tubes has been observed at BNGSB in the U-bend support region. Remedial measures are being taken to address the current problems. Solutions are being evaluated to reduce the generation of corrosion products in the feedtrain and their subsequent transport to the steam generators. (author)

  6. Ontario Hydro's operating experience with steam generators with specifics on Bruce A and Bruce B problems

    International Nuclear Information System (INIS)

    Eatock, J.W.; Patterson, R.W.; Dyck, R.W.

    1991-01-01

    The performance of the steam generators in Ontario Hydro nuclear power stations is reviewed. This performance has generally been outstanding compared to world averages, with very low tube failure and plugging rates. Steam generator problems have made only minor contributions to Ontario Hydro nuclear station incapability factors. The mechanisms responsible for the the observed tube degradation and failures are described. The majority of the leaks have been due fatigue in the U-bend of the Bruce 'A' steam generators. There have been very few failures attributed to corrosion of the three tube materials used in Ontario Hydro steam generators. Recent performance has been deteriorating primarily due to deposit accumulation in the steam generators. Plugging of the broached holes in the upper support plates at Bruce 'A' has caused some derating of two units. Increases have been observed in the primary heat transport system reactor inlet temperature of several units. These increases may be attributed to steam generator tube surface fouling. In addition, several units have accumulated deep, hard sludge piles on the tube sheet, although little damage been observed. Recently some fretting of tubes has been observed at BNGSB in the U-bend support region. Remedial measures are being taken to address the current problems. Solutions are being evaluated to reduce the generation of corrosion products in the feedtrain and their subsequent transport to the steam generators. (author)

  7. Solution to selected occupational health problems in the operation of large machinery in potash mines

    Energy Technology Data Exchange (ETDEWEB)

    Stuhrmann, D.

    1979-01-01

    This paper discusses health hazards, such as noise, vibrations and air pollution caused by the operation of large machines and their effect on the human body. Means of reducing the influence of these factors are: improved ear protection against noise, special gymnastics at the end of each shift, warm water swimming and a weekly sauna treatment for the effects of vibrations. Air pollution caused by diesel engines is monitored. Engine exhaust standards are examined in detail and methods are proposed to further reduce air pollution.

  8. A Prefiltered Cuckoo Search Algorithm with Geometric Operators for Solving Sudoku Problems

    Directory of Open Access Journals (Sweden)

    Ricardo Soto

    2014-01-01

    Full Text Available The Sudoku is a famous logic-placement game, originally popularized in Japan and today widely employed as pastime and as testbed for search algorithms. The classic Sudoku consists in filling a 9×9 grid, divided into nine 3×3 regions, so that each column, row, and region contains different digits from 1 to 9. This game is known to be NP-complete, with existing various complete and incomplete search algorithms able to solve different instances of it. In this paper, we present a new cuckoo search algorithm for solving Sudoku puzzles combining prefiltering phases and geometric operations. The geometric operators allow one to correctly move toward promising regions of the combinatorial space, while the prefiltering phases are able to previously delete from domains the values that do not conduct to any feasible solution. This integration leads to a more efficient domain filtering and as a consequence to a faster solving process. We illustrate encouraging experimental results where our approach noticeably competes with the best approximate methods reported in the literature.

  9. Tsetse Fly Genome Breakthrough: The FAO and IAEA Crack the Code

    International Nuclear Information System (INIS)

    Dixit, Aabha

    2014-01-01

    With the breakthrough in sequencing the genome of the tsetse fly species Glossina morsitans in April 2014, another milestone has been achieved in helping to solve a problem that has had horrendous ramifications for Africa. Finding a solution to the havoc created by tsetse flies to livestock has been a major challenge for the combined scientific efforts of the IAEA and the Food and Agriculture Organization of the United Nations (FAO), as well as for the World Health Organization (WHO), which has focused on combating human sleeping sickness. Joint research over the past decades to block the spread of severe infection from tsetse flies resulted in the introduction by the FAO and IAEA of the environmentally friendly sterile insect technique (SIT), a biologically-based method for the management of key insect pests of agricultural, medical and veterinary importance. A form of insect birth control, the SIT involves releasing mass-bred male flies that have been sterilized by low doses of radiation into infested areas, where they mate with wild females. These do not produce offspring and, as a result, the technique can suppress and, if applied systematically on an area-wide basis, eventually eradicate populations of wild flies. The newly acquired knowledge of the tsetse fly genome provides a wealth of information for the improvement of the entire SIT package and can help unravel interactions between tsetse flies, symbionts and trypanosomes. The decoding of the genome was detailed in a press release issued by the IAEA on 24 April 2014 entitled Tsetse Fly Genome Breakthrough Brings Hope for African Farmers. Tsetse flies were successfully eradicated in 1997 from the Tanzanian island of Zanzibar using the SIT. Ethiopia and Senegal are making significant progress in infested areas with the same method. The FAO and IAEA are helping 14 countries control tsetse populations through applying area-wide integrated pest management approaches

  10. Electrodynamics as a problem of eigenvalues. III. Maxwell operator and perturbation theory

    International Nuclear Information System (INIS)

    Yudin, L.A.; Kapchinsky, M.I.; Korenev, I.L.; Efimov, S.P.

    1996-01-01

    This part of the work deals with perturbation theory. The standard technique permits us to solve problems of volume disturbances in free space, waveguides, and cavities, of disturbances of boundary conditions caused by finite conductivity of walls, and of disturbances of the boundary shape. Expressions for frequency and wave number shifts caused by the perturbation are obtained by the unified method. Several examples are presented: wave amplification in the waveguide filled with a resonant medium like an electron beam in a longitudinal magnetic field, the frequency shift (and increment/decrement) of a cavity loaded by an electron beam, and the field disturbance in the waveguide caused by finite conductivity of the walls. copyright 1996 American Institute of Physics

  11. Compressed modes for variational problems in mathematical physics and compactly supported multiresolution basis for the Laplace operator

    Science.gov (United States)

    Ozolins, Vidvuds; Lai, Rongjie; Caflisch, Russel; Osher, Stanley

    2014-03-01

    We will describe a general formalism for obtaining spatially localized (``sparse'') solutions to a class of problems in mathematical physics, which can be recast as variational optimization problems, such as the important case of Schrödinger's equation in quantum mechanics. Sparsity is achieved by adding an L1 regularization term to the variational principle, which is shown to yield solutions with compact support (``compressed modes''). Linear combinations of these modes approximate the eigenvalue spectrum and eigenfunctions in a systematically improvable manner, and the localization properties of compressed modes make them an attractive choice for use with efficient numerical algorithms that scale linearly with the problem size. In addition, we introduce an L1 regularized variational framework for developing a spatially localized basis, compressed plane waves (CPWs), that spans the eigenspace of a differential operator, for instance, the Laplace operator. Our approach generalizes the concept of plane waves to an orthogonal real-space basis with multiresolution capabilities. Supported by NSF Award DMR-1106024 (VO), DOE Contract No. DE-FG02-05ER25710 (RC) and ONR Grant No. N00014-11-1-719 (SO).

  12. New problem with sales, inventories, and operations planning in a supply chain environment

    Science.gov (United States)

    Thomas, Andre; Lamouri, Samir

    2000-10-01

    The highest level of planning and control system is necessary, because production and logistics systems are not so flexible to follow, from day to day, sales evolutions. The companies are therefore held to standardize the good practices concerning the elaboration of their Sales, Inventories and Operations Planning (SIOP). The SIOP makes it possible to implement the strategic objectives defined by Top Management at the time of the Business Plan. It is the link between sales and manufacturing planning. The objectives of each of those depend on the specificity of their trade: the Sales Department will go for a maximum sales whereas Production will endeavor to keep industrial cost prices as low as possible while the Finance Department will try to optimize the use of available funds. There are several tools for this optimization: Graphical method and linear programming. Today, the economic context requires robust optimization.

  13. Phenomenological study of the QCD vacuum. Problems relevant to factorizability of four-fermion operators

    International Nuclear Information System (INIS)

    Zhitnitskij, A.R.

    1985-01-01

    The method of QCD sum rules is used here to evaluate vacuUm expectation values (VEV) for various four-fermion operators. It is found that the VEV (anti uσsub(μν) lambda sup(α)d anti d σsub(μν) lambda sup(α)u) is by a factor of 3-3.5 larger than the factorized quantity, while the VEV (anti u lambda sup(α) d anti d lambda sup(α) u) is smaller by a factor of 3-5 A by-product of the work is a phenomenological estimate for the VEV (gsup(3)fsup(abc)Gsub(μν)sup(α)Gsub(ν lambda)sup(b)Gsub(lambda μ)sup(c)) approximately equal to 0.06 GeV 6

  14. Monitoring of the operation of a nuclear power station with design problems in an importing country: The Almaraz power station

    International Nuclear Information System (INIS)

    Reig, J.

    1984-01-01

    The purpose of this paper is to describe the regulatory activities carried out in Spain as a result of the design problem occurring in the steam generators during operation of Unit I of the Almaraz nuclear power station. First, a brief introduction is given to the operating history and characteristics of Unit I of Almaraz. Particular attention is paid to the specific licences issued subsequent to commercial operation which place limitations on the operation of the station and to the operational incidents of which the Nuclear Safety Council (CSN) has been notified. Next, a description is provided of the safety evaluation carried out by the CSN. Three aspects merit particular attention: methodology, evaluation and conclusions. The methodology applied by an importing country is normally based on that of the country of origin of the design, so that the overall evaluation by the NRC has been considered sufficiently representative of aspects specific to the Almaraz power station. In this regard the importance of international collaboration is clearly seen as a principal instrument for performing the evaluation. In the evaluation a distinction is made between general and specific aspects and between inspection programmes and quality assurance requirements. In addition, the conclusions leading to the requirement of the imposition of additional limitations on the operating licence are stated. Apart from the safety evaluation carried out by the CSN, other regulatory activities have been performed over this two-year period. These activities, which include site inspections, audits of the principal supplier company, other independent calculations and so on, are described. Lastly, the paper refers to the lessons learned from the operation of the above-mentioned unit, which are immediately applicable to other Spanish nuclear power stations. (author)

  15. Consequences and potential problems of operating room outbursts and temper tantrums by surgeons.

    Science.gov (United States)

    Jacobs, George B; Wille, Rosanne L

    2012-01-01

    Anecdotal tales of colorful temper tantrums and outbursts by surgeons directed at operating room nurses and at times other health care providers, like residents and fellows, are part of the history of surgery and include not only verbal abuse but also instrument throwing and real harassment. Our Editor-in-Chief, Dr. Nancy Epstein, has made the literature review of "Are there truly any risks and consequences when spine surgeons mistreat their predominantly female OR nursing staff/colleagues, and what can we do about it?," an assigned topic for members of the editorial board as part of a new category entitled Ethical Note for our journal. This is a topic long overdue and I chose to research it. There is no medical literature to review dealing with nurse abuse. To research this topic, one has to involve business, industry, educational institutions, compliance standards and practices, and existing state and federal laws. I asked Dr. Rosanne Wille to co-author this paper since, as the former Dean of Nursing and then Provost and Senior Vice President for Academic Affairs at a major higher educational institution, she had personal experience with compliance regulations and both sexual harassment and employment discrimination complaints, to make this review meaningful. A review of the existing business practices and both state and federal laws strongly suggests that although there has not been any specific legal complaint that is part of the public record, any surgeon who chooses to act out his or her frustration and nervous energy demands by abusing co-workers on the health care team, and in this case specifically operating room personnel, is taking a chance of making legal history with financial outcomes which only an actual trial can predict or determine. Even more serious outcomes of an out-of-control temper tantrum and disruptive behavior can terminate, after multiple hearings and appeals, in adverse decisions affecting hospital privileges. Surgeons who abuse other

  16. The New Three Rs: Research, Reading, and Results. Breakthrough to Literacy[TM].

    Science.gov (United States)

    McGraw-Hill Companies, New York, NY. Educational and Professional Publishing Group.

    Research in school districts throughout the United States shows that children who use "Breakthrough to Literacy" achieve significant and lasting improvement in their reading skills. At virtually every site studied where implementation criteria were met, children who participated in "Breakthrough" demonstrated marked increases…

  17. Alternative sample-introduction technique to avoid breakthrough in gradient-elution liquid chromatography of polymers

    NARCIS (Netherlands)

    Reingruber, E.; Bedani, F.; Buchberger, W.; Schoenmakers, P.

    2010-01-01

    Gradient-elution liquid chromatography (GELC) is a powerful tool for the characterization of synthetic polymers. However, gradient-elution chromatograms often suffer from breakthrough phenomena. Breakthrough can be averted by using a sample solvent as weak as the mobile phase. However, this approach

  18. Lagrangian relaxation technique in power systems operation planning: Multipliers updating problem

    Energy Technology Data Exchange (ETDEWEB)

    Ruzic, S. [Electric Power Utility of Serbia, Belgrade (Yugoslavia)

    1995-11-01

    All Lagrangian relaxation based approaches to the power systems operation planning have an important common part: the Lagrangian multipliers correction procedure. It is the subject of this paper. Different approaches presented in the literature are discussed and an original method for the Lagrangian multipliers updating is proposed. The basic idea of this new method is to update Lagrangian multipliers trying to satisfy Khun-Tucker optimality conditions. Instead of the dual function maximization the `distance of optimality function` is defined and minimized. If Khun-Tucker optimality conditions are satisfied the value of this function is in range (-1,0); otherwise the function has a big positive value. This method called `the distance of optimality method` takes into account future changes in planning generations due to the Lagrangian multipliers updating. The influence of changes in a multiplier associated to one system constraint to the satisfaction of some other system requirements is also considered. The numerical efficiency of the proposed method is analyzed and compared with results obtained using the sub-gradient technique. 20 refs, 2 tabs

  19. The use of stability indices in predicting asphaltene problems in upstream and downstream oil operations

    Energy Technology Data Exchange (ETDEWEB)

    Asomaning, S. [Baker Petrolite, Sugar Land, TX (United States)

    2003-07-01

    A series of test methods have been developed to determine the stability of asphaltenes in crude oils. They were developed due to the high cost of remediating asphaltene deposition in offshore operations. This study described the characteristics of the Oliensis Spot Test, two saturates, aromatics, resins and asphaltenes (SARA)-based screens (the Colloidal Instability Index and Asphaltene-Resin ratio), a solvent titration method with near infrared radiation (NIR) solids detection, and live oil depressurization. Each method is used to predict the stability of asphaltenes in crude oils with different API gravity. A complete description of the test methods was provided along with experimental data. The effectiveness of the different tests in predicting the stability of asphaltenes in crude oils was also assessed. Results indicate that the prediction of a crude oil's tendency towards asphaltene precipitation was more accurate with the Colloidal Instability Index and the solvent titration method. Live oil depressurization proved to be very effective in predicting the stability of asphaltenes for light oils, where most stability tests fail. tabs., figs.

  20. Operational problems related to the preparation of the seawater soluble fraction of crude oil.

    Science.gov (United States)

    Ziolli, Roberta L; Jardim, Wilson F

    2002-02-01

    Owing to the importance of dissolution and weathering processes following oil spills, this work focused on the operational (quantitative) aspects related to the dissolution of petroleum-derived products, as well as the influence of solar light on both dissolution and the photoproduction of hydrogen peroxide. Four Brazilian crude oil samples were used to study the transfer process of organic compounds from the crude oil film to the aqueous phase (natural seawater) over a period of up to 45 days. Dissolved organic carbon (DOC), measured by non-dispersive infrared spectroscopy followed by high temperature catalytic combustion, was used to follow the partitioning between the two phases. Aqueous DOC values increased as a function of time (up to 15 days) until equilibrium was reached at concentrations ranging from 5 to 45 mg C L(-1). The final DOC concentration as well as the rate of dissolution depends on the nature of the crude oil. When exposed to sunlight, the dissolution was enhanced by up to 67.3%, and inorganic peroxides were generated in the concentration range from 4.5 up to 8.0 micromol L(-1) after 7.3 h irradiation. These results indicate that there is a need for a standard procedure for the production of the WSF in order to generate a more reliable tool to assess the impact of oil spills on the marine environment.

  1. Implementation of ORT: some problems encountered in training of health workers during an operational research programme.

    Science.gov (United States)

    Gupta, D N; SenGupta, P G; Sircar, B K; Mondal, S; Sarkar, S; Deb, B C

    1994-01-01

    During an operational research study on implementation of oral rehydration therapy in a block of West Bengal, India, amongst a population of 2, 16,805, a total of 171 Community Health Guides and 152 Anganwadi Workers were initially trained for one working day by lectures and slides about diarrhoea case management at the community level. The training was evaluated after two months and found to be inadequate. The workers were then retrained with modern approach using a module (prepared in local language) as suggested by World Health Organisation. The level of retention of the imparted knowledge of Health Workers for different items 2-3 months after training with lectures and slides ranged between 5-25% except preparation of ORS which was 80%. With the use of modules, 47-98% of health workers could retain the same knowledge 3 months after the training. The knowledge thus acquired were sustained even after 12 months of training to a level which was still much better than that retained 2 months after training with slides and lectures. However some of the items like indication of use of Home Available Fluids, dosage of ORS and when to refer a diarrhoea case to health facility were more difficult to recall after one year. This possibly indicates need for in-service training of grassroot level health workers at suiTable interval.

  2. A NEW APPROACH TO SOLVING GENERAL ANAESTHESIA INDIVIDUALIZATION PROBLEM DURING SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS

    Directory of Open Access Journals (Sweden)

    V. M. Magilevets

    2009-01-01

    Full Text Available The computerized system to control depth of anesthesia during surgical operation was developed in our research center. The depth of anesthesia is regulated by controlled intravenous infusion of propofol. The varied propofol rate is controlled by the closed-loop propofol system (CLPS with mean arterial pressure (MAP controller. MAP is used in the CLPS as input parameter and indicator of anesthesia depth. CLPS consists PC, invasive blood pressure (BP sensor and Graseby 3400 infusion pump. The C language computer program sets the propofol infusion rate based on empirical algorithm including proportional component to maintain the measured MAP more closely to the target MAP (85% of patient standard MAP. The propofol concentrations are calculated by Runge–Kutta’s method PK/PD model differential equations solving with Marsh’s microconstants and Kazama’s BIS effect site microconstant and age depended BP effect site microconstants every 30 s. The designed CLPS was effective and useful for anesthesia maintenance during open-heart surgery, especially for early extubation. 

  3. How should epistemic uncertainty in modelling water resources management problems shape evaluations of their operations?

    Science.gov (United States)

    Dobson, B.; Pianosi, F.; Reed, P. M.; Wagener, T.

    2017-12-01

    In previous work, we have found that water supply companies are typically hesitant to use reservoir operation tools to inform their release decisions. We believe that this is, in part, due to a lack of faith in the fidelity of the optimization exercise with regards to its ability to represent the real world. In an attempt to quantify this, recent literature has studied the impact on performance from uncertainty arising in: forcing (e.g. reservoir inflows), parameters (e.g. parameters for the estimation of evaporation rate) and objectives (e.g. worst first percentile or worst case). We suggest that there is also epistemic uncertainty in the choices made during model creation, for example in the formulation of an evaporation model or aggregating regional storages. We create `rival framings' (a methodology originally developed to demonstrate the impact of uncertainty arising from alternate objective formulations), each with different modelling choices, and determine their performance impacts. We identify the Pareto approximate set of policies for several candidate formulations and then make them compete with one another in a large ensemble re-evaluation in each other's modelled spaces. This enables us to distinguish the impacts of different structural changes in the model used to evaluate system performance in an effort to generalize the validity of the optimized performance expectations.

  4. On the solution of the inverse scattering problem for the quadratic bundle of the one-dimensional Schroedinger operators of the whole axis

    International Nuclear Information System (INIS)

    Maksudov, F.G.; Gusejnov, G.Sh.

    1986-01-01

    Inverse scattering problem for the quadratic bundle of the Schroedinger one-dimensional operators in the whole axis is solved. The problem solution is given on the assumption of the discrete spectrum absence. In the discrete spectrum presence the inverse scattering problem solution is known for the Shroedinger differential equation considered

  5. The problem of the first return attached to a pseudodifferential operator in dimension 3

    Directory of Open Access Journals (Sweden)

    Oscar F. Casas-Sánchez

    2015-12-01

    Full Text Available In this article we study the problem of first return associated to an elliptic pseudodifferential operator with non-radial symbol of dimension 3 over the p-adics. Resumen.El problema del primer retorno asociado a un operador seudodiferencial en dimensión 3 En este artículo estudiamos el problema del primer retorno asociado a un operador seudodiferencial elíptico con símbolo no radial de dimensión 3 sobre el cuerpo de los números pádicos.

  6. Urban Agriculture Practices and Health Problems among Farmers Operating on a University Campus in Kumasi, Ghana

    Directory of Open Access Journals (Sweden)

    Nana O.B. Ackerson

    2010-06-01

    Full Text Available Urban agriculture, a world-wide practice, faces both environmental and health challenges. Farmers are susceptible to occupational and other water-related health risks. The research identified health problems related to urban agricultural farming through farmers’ social characteristics and agricultural practices. Thorough interviews, using structured questionnaires, were carried out. Sixty three farmers responded to questions ranging from agricultural practices to health problems encountered. The findings showed that farmers apply both organic and inorganic fertilisers while 97% used pesticides of varying active ingredients at different application rates. Only 10% used personal protective clothing during the application of pesticides. Overhead irrigation was carried out using a watering can. Eighty four percent and 13% of the respondents utilised water from shallow wells and shallow wells mixed with contaminated stream, respectively. Besides schistosomiasis and cholera, other bacterial diseases, nematode infections, malaria, headaches, dermatological, visual, cardiac, and respiratory problems were common health complaints. Headache complaints were the most common (75%.L’agriculture urbaine, une pratique qui a cours dans le monde entier, est confrontée à des défis d’ordre environnemental et sanitaire. Les agriculteurs sont exposés à divers risques professionnels, et notamment à ceux que l'eau peut poser pour leur santé. Cette étude a identifié les problèmes de santé liés à l’agriculture urbaine en fonction des caractéristiques sociales et des pratiques des agriculteurs. Des entretiens approfondis ont été conduits en suivant des questionnaires structurés. Soixante-trois fermiers ont répondu aux questions, qui abordaient leurs pratiques agricoles ainsi que leurs problèmes de santé. Les résultats montrent que les fermiers emploient aussi bien des engrais organiques que non organiques, et que 97 % utilisent des pesticides

  7. Beyond the traditional definition of breakthrough pain: an observational study.

    Science.gov (United States)

    Gatti, Antonio; Gentili, Marta; Iorno, Vittorio; Mammucari, Massimo; Tufaro, Giuseppe; Lazzari, Marzia; Sabato, Alessandro Fabrizio

    2013-03-01

    Breakthrough pain (BTP) is traditionally defined as a transitory pain flare in opioid-treated patients with chronic background pain. This definition has, however, been challenged in recent years. This study aimed to analyze BTP prevalence in different pain conditions. This was a prospective, non-interventional, observational study conducted from June to September 2011 in two Italian pain treatment reference centres. Consecutive patients aged >18 years with oncological or non-oncological pain were eligible for this study; background pain was acute/ subacute (3 months). The characteristics of pain were evaluated by means of a structured interview by physicians, and patients were asked to complete a dedicated clinical study form. The following outcomes were assessed: chronic pain duration (in patients with chronic pain), BTP prevalence, and number and severity of daily BTP episodes. All outcomes were assessed in four populations of patients with: (a) chronic oncological pain; (b) chronic non-oncological pain; (c) non-chronic oncological pain; (d) non-chronic non-oncological pain. The correlation between BTP and gender was also investigated. Of 1,270 patients with chronic pain, 1,086 had non-oncological pain (85.5%). Most patients (68.6%) with non-oncological pain were female (P = 0.001). Pain duration was significantly longer in non-oncological pain versus oncological pain groups (P = 0.002). BTP prevalence was lower in non-oncological patients (P definition. BTP frequency and severity is similar in oncological and non-oncological pain.

  8. Soil homogeneity evaluation by radionuclide tracer breakthrough curve interpretation

    International Nuclear Information System (INIS)

    Brenizer, J.S. Jr.; Jarrett, A.R.; Jester, W.A.

    1980-01-01

    Increasing concern about the environmental impact of hazardous waste disposal has made site evaluation and site selection difficult and expensive. Pollutants, assumed to be absorbed by the soil immediately surrounding the burial trench, have been detected far from sites. Discrepancies between predicted migration distances based on indirect methods such as laboratory and computer modeling and those observed at the field site are often significant. The homogeneity of subsurface media, often assumed in laboratory and modeling studies, is seldom found in the field. The use of tracers to determine the flow characteristics of a potential disposal site involves time and expense, but offers a direct evaluation of solute transport and eliminates the assumptions inherent in indirect methods. Current modeling of solute transport in nonhomogeneous porous media is limited by the quantification of input parameters. Several general models can predict solute transport in saturated-unsaturated media from low-level disposal sites if the hydraulic characteristics and chemical reactions expected in each unique water-solute-media system can be defined. The objective of this research was to develop a method of evaluating potential shallow-land burial waste disposal sites by interpreting tracer breakthrough curve structure with respect to the hydrologic properties of the media at the potential disposal site. This methodology will be helpful in evaluating the potential performance of many types of shallow-land waste burial sites such as low-level radioactive waste disposal, surface disposal of flyash, chemical waste disposal, waste sedimentation ponds, and sanitary landfills

  9. From Islamicizing the Sciences to Strategizing for Muslims’ Scientific Breakthrough

    Directory of Open Access Journals (Sweden)

    RAFIU IBRAHIM ADEBAYO

    2015-06-01

    Full Text Available At inception, science and religion were seen as poles apart and so science was vehemently kicked against by religious leaders. Islam later came to bridge the gap between religion and science only to be later hijacked by the Western world and so science was rewritten from a purely materialist point of view; hence, experts in modern science became over-confident and arrogant to have relegated religion to the lowest ebb and looked down upon any knowledge which could not be scientifically proved. However attempts are being made to reconcile religion and science by Muslim reformers. These attempts are not without their shortcomings, hence the need for Islamization of the sciences for them to conform to the Islamic principle of unity of knowledge. However, the present researcher feels that there should be a step forward from the contemporary approaches to Islamicizing the sciences in form of colouring the Western scientific discoveries Islam, to making their own scientific breakthroughs, the type which immortalized Muslim scientists of the Islam’s golden ages. Without this, Muslims will continue to be mere consumers of the Western products. The strategy for the Ummah to achieve this is suggested in this paper.

  10. Funding breakthrough therapies: A systematic review and recommendation.

    Science.gov (United States)

    Hanna, E; Toumi, M; Dussart, C; Borissov, B; Dabbous, O; Badora, K; Auquier, P

    2018-03-01

    Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of the healthcare system. The aims of this study were to identify, define, classify and compare the approaches to funding high-cost medicines proposed in the literature, to analyze their appropriateness for ATMP funding and to suggest an optimal funding model for ATMPs. Forty-eight articles suggesting new funding models for innovative high-cost therapies were identified. The models were classified into 3 groups: financial agreement, health outcomes-based agreement and healthcoin. Financial agreement encompassed: discounts, rebates, price and volume caps, price-volume agreements, loans, cost-plus price, intellectual-based payment and fund-based payment. Health outcomes-based agreements were defined as agreements between manufacturers and payers based on drug performance, and were divided into performance-based payment and coverage with evidence development. Healthcoin described a new suggested tradeable currency used to assign monetary value to incremental outcomes. With a large number of ATMPs in development, it is time for stakeholders to start thinking about new pathways and funding strategies for these innovative high-cost therapies. An "ATMP-specific fund" may constitute a reasonable solution to ensure rapid patient access to innovation without threatening the sustainability of the health care system. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. How Students Combine Resources to Make Conceptual Breakthroughs

    Science.gov (United States)

    Richards, A. J.; Jones, Darrick C.; Etkina, Eugenia

    2018-04-01

    We use the framework of cognitive resources to investigate how students construct understanding of a complex physics topic, namely, a photovoltaic cell. By observing students as they learn about how a solar cell functions, we identified over 60 distinct resources that learners may activate while thinking about photovoltaic cells. We classify these resources into three main types: phenomenological primitives, conceptual resources, and epistemological resources. Furthermore, we found a pattern that suggests that when students make conceptual breakthroughs they may be more likely to activate combinations of resources of different types in concert, especially if a resource from each of the three categories is used. This pattern suggests that physics instructors should encourage students to activate multiple types of prior knowledge during the learning process. This can result from instructors deliberately and explicitly connecting new knowledge to students' prior experience both in and outside the formal physics classroom, as well as allowing students to reflect metacognitively on how the new knowledge fits into their existing understanding of the natural world.

  12. Recent breakthroughs on C-2U: Norman’s legacy

    Energy Technology Data Exchange (ETDEWEB)

    Binderbauer, M. W.; Tajima, T.; Tuszewski, M.; Smirnov, A.; Gota, H.; Garate, E.; Barnes, D.; Deng, B. H.; Trask, E.; Yang, X.; Putvinski, S.; Andow, R.; Bolte, N.; Bui, D. Q.; Ceccherini, F.; Clary, R.; Cheung, A. H.; Conroy, K. D.; Dettrick, S. A.; Douglass, J. D. [Tri Alpha Energy, Inc., P.O. Box 7010, Rancho Santa Margarita, CA 92688 (United States); and others

    2016-03-25

    Conventional field-reversed configurations (FRC) face notable stability and confinement concerns, which can be ameliorated by introducing and maintaining a significant fast ion population in the system. This is the conjecture first introduced by Norman Rostoker multiple decades ago and adopted as the central design tenet in Tri Alpha Energy’s advanced beam driven FRC concept. In fact, studying the physics of such neutral beam (NB) driven FRCs over the past decade, considerable improvements were made in confinement and stability. Next to NB injection, the addition of axially streaming plasma guns, magnetic end plugs, as well as advanced surface conditioning lead to dramatic reductions in turbulence driven losses and greatly improved stability. In turn, fast ion confinement improved significantly and allowed for the build-up of a dominant fast particle population. This recently led to the breakthrough of sustaining an advanced beam driven FRC, thereby demonstrating successful maintenance of trapped magnetic flux, plasma dimensions and total pressure inventory for times much longer than all characteristic system time scales and only limited by hardware and electric supply constraints.

  13. Clean Energy Innovation: Sources of Technical and Commercial Breakthroughs

    Energy Technology Data Exchange (ETDEWEB)

    Perry, T. D., IV; Miller, M.; Fleming, L.; Younge, K.; Newcomb, J.

    2011-03-01

    Low-carbon energy innovation is essential to combat climate change, promote economic competitiveness, and achieve energy security. Using U.S. patent data and additional patent-relevant data collected from the Internet, we map the landscape of low-carbon energy innovation in the United States since 1975. We isolate 10,603 renewable and 10,442 traditional energy patents and develop a database that characterizes proxy measures for technical and commercial impact, as measured by patent citations and Web presence, respectively. Regression models and multivariate simulations are used to compare the social, institutional, and geographic drivers of breakthrough clean energy innovation. Results indicate statistically significant effects of social, institutional, and geographic variables on technical and commercial impacts of patents and unique innovation trends between different energy technologies. We observe important differences between patent citations and Web presence of licensed and unlicensed patents, indicating the potential utility of using screened Web hits as a measure of commercial importance. We offer hypotheses for these revealed differences and suggest a research agenda with which to test these hypotheses. These preliminary findings indicate that leveraging empirical insights to better target research expenditures would augment the speed and scale of innovation and deployment of clean energy technologies.

  14. Parameterizing the Spatial Markov Model from Breakthrough Curve Data Alone

    Science.gov (United States)

    Sherman, T.; Bolster, D.; Fakhari, A.; Miller, S.; Singha, K.

    2017-12-01

    The spatial Markov model (SMM) uses a correlated random walk and has been shown to effectively capture anomalous transport in porous media systems; in the SMM, particles' future trajectories are correlated to their current velocity. It is common practice to use a priori Lagrangian velocity statistics obtained from high resolution simulations to determine a distribution of transition probabilities (correlation) between velocity classes that govern predicted transport behavior; however, this approach is computationally cumbersome. Here, we introduce a methodology to quantify velocity correlation from Breakthrough (BTC) curve data alone; discretizing two measured BTCs into a set of arrival times and reverse engineering the rules of the SMM allows for prediction of velocity correlation, thereby enabling parameterization of the SMM in studies where Lagrangian velocity statistics are not available. The introduced methodology is applied to estimate velocity correlation from BTCs measured in high resolution simulations, thus allowing for a comparison of estimated parameters with known simulated values. Results show 1) estimated transition probabilities agree with simulated values and 2) using the SMM with estimated parameterization accurately predicts BTCs downstream. Additionally, we include uncertainty measurements by calculating lower and upper estimates of velocity correlation, which allow for prediction of a range of BTCs. The simulated BTCs fall in the range of predicted BTCs. This research proposes a novel method to parameterize the SMM from BTC data alone, thereby reducing the SMM's computational costs and widening its applicability.

  15. Improved quantum-inspired evolutionary algorithm with diversity information applied to economic dispatch problem with prohibited operating zones

    International Nuclear Information System (INIS)

    Vianna Neto, Julio Xavier; Andrade Bernert, Diego Luis de; Santos Coelho, Leandro dos

    2011-01-01

    The objective of the economic dispatch problem (EDP) of electric power generation, whose characteristics are complex and highly nonlinear, is to schedule the committed generating unit outputs so as to meet the required load demand at minimum operating cost while satisfying all unit and system equality and inequality constraints. Recently, as an alternative to the conventional mathematical approaches, modern meta-heuristic optimization techniques have been given much attention by many researchers due to their ability to find an almost global optimal solution in EDPs. Research on merging evolutionary computation and quantum computation has been started since late 1990. Inspired on the quantum computation, this paper presented an improved quantum-inspired evolutionary algorithm (IQEA) based on diversity information of population. A classical quantum-inspired evolutionary algorithm (QEA) and the IQEA were implemented and validated for a benchmark of EDP with 15 thermal generators with prohibited operating zones. From the results for the benchmark problem, it is observed that the proposed IQEA approach provides promising results when compared to various methods available in the literature.

  16. Improved quantum-inspired evolutionary algorithm with diversity information applied to economic dispatch problem with prohibited operating zones

    Energy Technology Data Exchange (ETDEWEB)

    Vianna Neto, Julio Xavier, E-mail: julio.neto@onda.com.b [Pontifical Catholic University of Parana, PUCPR, Undergraduate Program at Mechatronics Engineering, Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil); Andrade Bernert, Diego Luis de, E-mail: dbernert@gmail.co [Pontifical Catholic University of Parana, PUCPR, Industrial and Systems Engineering Graduate Program, LAS/PPGEPS, Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil); Santos Coelho, Leandro dos, E-mail: leandro.coelho@pucpr.b [Pontifical Catholic University of Parana, PUCPR, Industrial and Systems Engineering Graduate Program, LAS/PPGEPS, Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil)

    2011-01-15

    The objective of the economic dispatch problem (EDP) of electric power generation, whose characteristics are complex and highly nonlinear, is to schedule the committed generating unit outputs so as to meet the required load demand at minimum operating cost while satisfying all unit and system equality and inequality constraints. Recently, as an alternative to the conventional mathematical approaches, modern meta-heuristic optimization techniques have been given much attention by many researchers due to their ability to find an almost global optimal solution in EDPs. Research on merging evolutionary computation and quantum computation has been started since late 1990. Inspired on the quantum computation, this paper presented an improved quantum-inspired evolutionary algorithm (IQEA) based on diversity information of population. A classical quantum-inspired evolutionary algorithm (QEA) and the IQEA were implemented and validated for a benchmark of EDP with 15 thermal generators with prohibited operating zones. From the results for the benchmark problem, it is observed that the proposed IQEA approach provides promising results when compared to various methods available in the literature.

  17. Improved quantum-inspired evolutionary algorithm with diversity information applied to economic dispatch problem with prohibited operating zones

    Energy Technology Data Exchange (ETDEWEB)

    Neto, Julio Xavier Vianna [Pontifical Catholic University of Parana, PUCPR, Undergraduate Program at Mechatronics Engineering, Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil); Bernert, Diego Luis de Andrade; Coelho, Leandro dos Santos [Pontifical Catholic University of Parana, PUCPR, Industrial and Systems Engineering Graduate Program, LAS/PPGEPS, Imaculada Conceicao, 1155, Zip code 80215-901, Curitiba, Parana (Brazil)

    2011-01-15

    The objective of the economic dispatch problem (EDP) of electric power generation, whose characteristics are complex and highly nonlinear, is to schedule the committed generating unit outputs so as to meet the required load demand at minimum operating cost while satisfying all unit and system equality and inequality constraints. Recently, as an alternative to the conventional mathematical approaches, modern meta-heuristic optimization techniques have been given much attention by many researchers due to their ability to find an almost global optimal solution in EDPs. Research on merging evolutionary computation and quantum computation has been started since late 1990. Inspired on the quantum computation, this paper presented an improved quantum-inspired evolutionary algorithm (IQEA) based on diversity information of population. A classical quantum-inspired evolutionary algorithm (QEA) and the IQEA were implemented and validated for a benchmark of EDP with 15 thermal generators with prohibited operating zones. From the results for the benchmark problem, it is observed that the proposed IQEA approach provides promising results when compared to various methods available in the literature. (author)

  18. De la Vallee Poussin problem in the kernel of the convolution operator on the half-plane

    Directory of Open Access Journals (Sweden)

    Valentin V. Napalkov

    2015-06-01

    Full Text Available We consider the multipoint de la Vallee Poussin (interpolational problem in the half-plane $D$, $D=ż  :  \\mathop{\\mathrm{Re}} z0\\}$. Let $\\psi(z\\in H(D$; $\\mu_1$, $\\mu_2$, $\\ldots \\in D$ be the positive zero points of this function and let the boundary of domain $D$ contain their limit. Also, we assume that $\\mu_k$ is of $s_k$ multiplicity, $k=1, 2, …$. Let us set $M_{\\varphi}$ an operator of convolution with the characteristic function $\\varphi(z$. Taking an arbitrary sequence $a_{kj},$ $j=0, 1, \\ldots, s_k-1$ we should ask: is there a function $u(z \\in \\mathop{\\mathrm{Ker}}M_\\varphi$ that provides the relation $u^{(j}(\\mu_{k}=a_{kj},$ $j=0, 1,…,s_k-1$? We assume the operator characteristic function to be of completely regular growth. The solvability conditions for the multipoint de la Vallée Poussin problem in the half-plain and in the bounded convex domains are obtained.

  19. Solvability of fractional multi-point boundary-value problems with p-Laplacian operator at resonance

    Directory of Open Access Journals (Sweden)

    Tengfei Shen

    2014-02-01

    Full Text Available In this article, we consider the multi-point boundary-value problem for nonlinear fractional differential equations with $p$-Laplacian operator: $$\\displaylines{ D_{0^+}^\\beta \\varphi_p (D_{0^+}^\\alpha u(t = f(t,u(t,D_{0^+}^{\\alpha - 2} u(t,D_{0^+}^{\\alpha - 1} u(t, D_{0^+}^\\alpha u(t,\\quad t \\in (0,1, \\cr u(0 = u'(0=D_{0^+}^\\alpha u(0 = 0,\\quad D_{0^+}^{\\alpha - 1} u(1 = \\sum_{i = 1}^m {\\sigma_i D_{0^+}^{\\alpha - 1} u(\\eta_i } , }$$ where $2 < \\alpha \\le 3$, $0 < \\beta \\le 1$, $3 < \\alpha + \\beta \\le 4$, $\\sum_{i = 1}^m {\\sigma_i } = 1$, $D_{0^+}^\\alpha$ is the standard Riemann-Liouville fractional derivative. $\\varphi_{p}(s=|s|^{p-2}s$ is p-Laplacians operator. The existence of solutions for above fractional boundary value problem is obtained by using the extension of Mawhin's continuation theorem due to Ge, which enrich konwn results. An example is given to illustrate the main result.

  20. The role of crossover operator in evolutionary-based approach to the problem of genetic code optimization.

    Science.gov (United States)

    Błażej, Paweł; Wnȩtrzak, Małgorzata; Mackiewicz, Paweł

    2016-12-01

    One of theories explaining the present structure of canonical genetic code assumes that it was optimized to minimize harmful effects of amino acid replacements resulting from nucleotide substitutions and translational errors. A way to testify this concept is to find the optimal code under given criteria and compare it with the canonical genetic code. Unfortunately, the huge number of possible alternatives makes it impossible to find the optimal code using exhaustive methods in sensible time. Therefore, heuristic methods should be applied to search the space of possible solutions. Evolutionary algorithms (EA) seem to be ones of such promising approaches. This class of methods is founded both on mutation and crossover operators, which are responsible for creating and maintaining the diversity of candidate solutions. These operators possess dissimilar characteristics and consequently play different roles in the process of finding the best solutions under given criteria. Therefore, the effective searching for the potential solutions can be improved by applying both of them, especially when these operators are devised specifically for a given problem. To study this subject, we analyze the effectiveness of algorithms for various combinations of mutation and crossover probabilities under three models of the genetic code assuming different restrictions on its structure. To achieve that, we adapt the position based crossover operator for the most restricted model and develop a new type of crossover operator for the more general models. The applied fitness function describes costs of amino acid replacement regarding their polarity. Our results indicate that the usage of crossover operators can significantly improve the quality of the solutions. Moreover, the simulations with the crossover operator optimize the fitness function in the smaller number of generations than simulations without this operator. The optimal genetic codes without restrictions on their structure

  1. ENEL's experience in the management of irradiated fuel. Old and new problems encountered by nuclear station operators

    International Nuclear Information System (INIS)

    Ariemma, A.; Cuzzaniti, M.; Zaffiro, B.; Bertini, A.

    1983-01-01

    The experience acquired in recent years in the management of spent fuel discharged from ENEL's reactors has revealed a substantial change in the attitude of nuclear station operators in connection with the end of the fuel cycle downstream from the reactor (back-end). While in the past, after President Carter's outline of US policy in April 1977, the utilities had to face great difficulty in reprocessing their fuel owing to inadequate capacity, today the same problem is regarded as a matter of cost-benefit analysis from an industrial standpoint and of appropriate planning for the utilization of the recovered fissile materials. Since the present technology allows spent fuel storage (dry or underwater) to be planned for rather long periods and plutonium utilization requires a very stringent schedule, the present trend is to ensure medium-term storage of spent fuel and to seek a greater flexibility in the final reprocessing stages so as to render plutonium availability consistent with the programmes for its utilization. As a consequence, the solution to the problems posed by high-activity waste disposal is being delayed, thus allowing an exhaustive and detailed analysis of all the possible solutions to be made. The paper describes a number of solutions to the problems ENEL has encountered in the fuel cycle back-end. (author)

  2. PSYCHOLOGICAL PROBLEMS AND STRESS FACED BY SOLDIERS WHO OPERATE IN ASYMMETRIC WARFARE ENVIRONMENTS: EXPERIENCES IN THE FIELD

    Directory of Open Access Journals (Sweden)

    Giuseppe CAFORIO

    2014-10-01

    Full Text Available This article deals with the problems of anxiety, stress and psychological discomfort that can affect soldiers sent on asymmetric warfare operations. It is based on secondary analysis of the data of two important field researches whose results have recently (2013 been published. Although the two researches adopted different methodologies, the testimonies are fully comparable and show that soldiers from different countries and cultures display common or similar reactions when they are placed in the stress conditions that the asymmetric environment involves. The approach of the paper is drawn up in such a way as to make the reader a participating observer of the reality of such missions. It is therefore centered on the personal testimonies of the soldiers interviewed in the two researches, testimonies reported just as they are, in their simplicity and, often, drama, with comments by the author kept to a minimum in order to give readers ample opportunity to evaluate and interpret the reported texts on their own. The research data, drawn from the declarations of those directly concerned, reveal the existence of a problem of psychological distress resulting from deployment in asymmetric warfare situations that is in part different in the causes of the problems resulting from deployment in traditional combat and affects percentages of participating soldiers that are not high but definitely significant. The highest incidence appears to be constituted by problems relating to reintegration into normal social and working life upon returning from the mission. This is followed in percentage terms by anxiety situations relating to life far from the family, due in large part to a sense of powerlessness for the scant possibility of managing family situations that may have cropped up or already existed beforehand.

  3. Observational study to analyze patterns of treatment of breakthrough dyspnea in cancer patients in clinical practice.

    Science.gov (United States)

    Cabezón-Gutiérrez, Luis; Delgado-Mingorance, Ignacio; Nabal-Vicuña, María; Jiménez-López, Antonio Javier; Cabezón-Álvarez, Ana; Soler-López, Begoña

    2018-06-12

    Although breakthrough dyspnea is very frequent in cancer patients, there are no precise recommendations for treating it. The main objective of this study was to analyze what treatments are used in clinical practice for the management of breakthrough dyspnea in cancer patients in Spain and the secondary objectives were to describe the characteristics of cancer patients with breakthrough dyspnea and the attributes of the disorder. Cancer patients over 18 years of age, with breakthrough dyspnea and a Karnofsky performance score of ≥30, who were treated at departments of oncology in institutes across Spain were included in this cross-sectional observational study. The characteristics of breakthrough dyspnea, history of treatment, anthropometric variables, Mahler dyspnea index, Borg scale, Edmonton Symptoms Assessment Scale, and patient satisfaction with current breakthrough dyspnea treatment were assessed. The mean age of the 149 included patients was 66 years (95% confidence interval: 64.3 to 67.9), and 53 were females (35.6%). The mean breakthrough dyspnea intensity was 5.85 (95% confidence interval 5.48 to 6.22, Borg scale). A total of 55.1% of the first-choice treatments consisted of opioids, followed by oxygen (17.3%). A total of 119 patients (79.9%) received monotherapy for breakthrough dyspnea. Patients presenting with basal dyspnea received oxygen in a greater proportion of cases (21.1% vs 7.4%; p = 0.07). Patients with predictable dyspnea received a greater proportion of opioids (70.9% vs 44.4%; p = 0.01). Opioids constitute first-line therapy for breakthrough dyspnea in routine clinical practice, though the scientific evidence supporting their use is scarce. Further information derived from controlled clinical trials is needed regarding the comparative efficacy of the different treatments in order to justify their use.

  4. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Bouzigues, H; Boutot, P [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    This article deals with effective methods to struggle radioactive contamination using rationally designed working clothes. The choice of the cloth is important and cotton, because of its absorbent properties constitutes an effective barrier to radioelements failing on its surface. Clothing the personnel of large nuclear industrial concerns is a big problem which can only be solved by carefully studied methods. The decontamination and washing of large amounts of clothes whose flow increases during periods of radio-active incidents have to be treated as are those operations in hospital laundering. Linen washing by the German counter-current method (the Sulzman system) is of great value because of the volume which can be treated and, more important, because of the small amount of liquid waste produced. Dry cleaning is certainly a method of the future and is even more economic than the preceding one. In 'active' laundries, the control of clothing for residual contamination can constitute a serious bottleneck in the production of clean clothing if automatic high-speed machines are not used. The risk to the operating personnel comes solely from contamination of the atmosphere and of the surfaces. Because of this, the plant must be considered as an active zone in which are handled several tens of millicuries of dangerous emitters and several micro- curies of plutonium daily. (authors) [French] Ce memoire traite des moyens efficaces de lutte contre la contamination radioactive que peuvent offrir des vetements de travail de conception rationnelle. Le choix du tissu est un element important et la fibre de coton, par ses proprietes absorbantes, constitue un excellent barrage aux radioelements deposes a sa surface. L'habillement du personnel des grands ensembles industriels de l'energie atomique est un gros probleme qui ne peut etre solutionne qu'avec des moyens soigneusement etudies. La decontamination et le lavage des grandes quantites de vetements renouveles a cadence

  5. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Bouzigues, H.; Boutot, P. [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    This article deals with effective methods to struggle radioactive contamination using rationally designed working clothes. The choice of the cloth is important and cotton, because of its absorbent properties constitutes an effective barrier to radioelements failing on its surface. Clothing the personnel of large nuclear industrial concerns is a big problem which can only be solved by carefully studied methods. The decontamination and washing of large amounts of clothes whose flow increases during periods of radio-active incidents have to be treated as are those operations in hospital laundering. Linen washing by the German counter-current method (the Sulzman system) is of great value because of the volume which can be treated and, more important, because of the small amount of liquid waste produced. Dry cleaning is certainly a method of the future and is even more economic than the preceding one. In 'active' laundries, the control of clothing for residual contamination can constitute a serious bottleneck in the production of clean clothing if automatic high-speed machines are not used. The risk to the operating personnel comes solely from contamination of the atmosphere and of the surfaces. Because of this, the plant must be considered as an active zone in which are handled several tens of millicuries of dangerous emitters and several micro- curies of plutonium daily. (authors) [French] Ce memoire traite des moyens efficaces de lutte contre la contamination radioactive que peuvent offrir des vetements de travail de conception rationnelle. Le choix du tissu est un element important et la fibre de coton, par ses proprietes absorbantes, constitue un excellent barrage aux radioelements deposes a sa surface. L'habillement du personnel des grands ensembles industriels de l'energie atomique est un gros probleme qui ne peut etre solutionne qu'avec des moyens soigneusement etudies. La decontamination et le lavage des grandes quantites de vetements

  6. Inverse resonance problems for the Schrödinger operator on the real line with mixed given data

    Science.gov (United States)

    Xu, Xiao-Chuan; Yang, Chuan-Fu

    2018-01-01

    In this work, we study inverse resonance problems for the Schrödinger operator on the real line with the potential supported in [0, 1]. In general, all eigenvalues and resonances cannot uniquely determine the potential. (i) It is shown that if the potential is known a priori on [0, 1 / 2], then the unique recovery of the potential on the whole interval from all eigenvalues and resonances is valid. (ii) If the potential is known a priori on [0, a], then for the case a>1/2, infinitely many eigenvalues and resonances can be missing for the unique determination of the potential, and for the case alogarithmic derivative values of eigenfunctions and wave-functions at 1 / 2, can uniquely determine the potential.

  7. Measures for simultaneous minimisation of alkali related operating problems; Aatgaerder foer samtidig minimering av alkalirelaterade driftproblem. Ramprogram

    Energy Technology Data Exchange (ETDEWEB)

    Davidsson, Kent; Eskilsson, David; Gyllenhammar, Marianne; Herstad Svaerd, Solvie; Kassman, Haakan; Steenari, Britt-Marie; Aamand, Lars-Erik

    2006-12-15

    Combustion of biofuel and waste wood is often accompanied by chlorine and alkali related operating problems such as slagging, deposit formation and corrosion on heat exchanger surfaces and bed agglomeration in fluidised bed boilers. In order to gain a greater insight into possible measures to overcome alkali related operating problems studies were carried out during 2005-2006. The results of the studies are presented in this report which includes work performed in the two following projects: 1 A5-509 Frame work - measures for simultaneous minimisation of alkali related operating problems 2 A5-505 Bed agglomeration risk related to combustion of cultivated fuels (wheat straw, red canary grass, industrial hemp) in commercial bed materials Full-scale experiments were carried out at Chalmers 12 MW{sub th} CFB boiler within the project A5-509. The purpose was to study the effect of various measures on bed agglomeration and deposit formation in connection with co-combustion of wood and straw pellets. The various measures included changing the bed material (blast furnace sand and olivine sand), adding various additives (kaolin, ammonium sulphate, elemental sulphur) and also co-combustion with sewage sludge. Furthermore results from kaolin experiments at the 26 MWth CFB boiler owned by Naessjoe Affaersverk were made available during the project and are also presented in this report. The results from the experiments at Chalmers revealed that, already at the lowest dosage of kaolin, approx. 2 kg/MWh, the bed material agglomeration temperatures increased significantly. The dosage of kaolin can presumably be reduced somewhat further while still maintaining the high agglomeration temperature. Experiments with a higher dosage of kaolin, 7 kg/MWh, proved that kaolin could also reduce the risk of deposit problems. The experiments at Naessjoe showed also that addition of kaolin increased the agglomeration temperature of the bed material. Addition of sulphur in any form resulted in a

  8. Operational exposition and analysis of the inverse problem electroencephalographic; Planteamiento operacional y analisis del problema inverso electroencefalografico

    Energy Technology Data Exchange (ETDEWEB)

    Fraguela Collar, Andres; Oliveros Oliveros, Jose J.; Ivanovich Grebennikov, Alexandre [Benemerita Universidad Autonoma de Puebla, Puebla (Mexico)

    2001-04-01

    Techniques of the potential theory have been used to analyze the properties of the operator where the sources of current produced by electric activity in the cerebral cortex is associated with the measurements on the scalp of the electric potential generated by these sources. A medium conductor model which take in account the circle convolution of the brain has been used to prove the uniqueness of solution of the inverse problem of recuperation of activity cortical sources from electroencephalographic measurement on the scalp. This result of uniqueness is very important because we can to use algorithms of regularization. An other state the problem is presented to elaborate numerical solutions of the inverse problem using a set of discrete measurement. The stability of algorithms is showed in some examples. [Spanish] Tecnicas de la teoria de potencial han sido utilizadas para analizar las propiedades del operador que a las fuentes de corriente asociadas a la actividad electrica de las neuronas en la corteza cerebral, le hace corresponder la medicion de potencial electrico generado por dichas fuentes sobre el cuero cabelludo. Un modelo de medio conductor que toma en consideracion las circonvoluciones del cerebro ha sido utilizado para probar la unidad de solucion del problema inverso de recuperacion de las fuentes de actividad cortical a partir de las mediciones electroencefalograficas. Este resultado de unidad es fundamental ya que nos permite aplicar los metodos de regularizacion. Es presentado otro planteamiento del problema que nos permite construir soluciones numericas del problema inverso usando los datos de entrada discretos. La estabilidad de los algoritmos es ilustrada en algunos ejemplos numericos.

  9. Computational tools for Breakthrough Propulsion Physics: State of the art and future prospects

    International Nuclear Information System (INIS)

    Maccone, Claudio

    2000-01-01

    To address problems in Breakthrough Propulsion Physics (BPP) one needs sheer computing capabilities. This is because General Relativity and Quantum Field Theory are so mathematically sophisticated that the amount of analytical calculations is prohibitive and one can hardly do all of them by hand. In this paper we make a comparative review of the main tensor calculus capabilities of the three most advanced and commercially available 'symbolic manipulator' codes: Macsyma, Maple V and Mathematica. We also point out that currently one faces such a variety of different conventions in tensor calculus that it is difficult or impossible to compare results obtained by different scholars in General Relativity and Quantum Field Theory. Mathematical physicists, experimental physicists and engineers have each their own way of customizing tensors, especially by using the different metric signatures, different metric determinant signs, different definitions of the basic Riemann and Ricci tensors, and by adopting different systems of physical units. This chaos greatly hampers progress toward the chief NASA BPP goal: the design of the NASA Warp Drive. It is thus concluded that NASA should put order by establishing international standards in symbolic tensor calculus and enforcing anyone working in BPP to adopt these NASA BPP Standards

  10. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

    Directory of Open Access Journals (Sweden)

    Diego Muñoz-Torrero

    2017-12-01

    Full Text Available Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...

  11. Statistical characteristics of breakthrough discoveries in science using the metaphor of black and white swans

    Science.gov (United States)

    Zeng, Carl J.; Qi, Eric P.; Li, Simon S.; Stanley, H. Eugene; Ye, Fred Y.

    2017-12-01

    A publication that reports a breakthrough discovery in a particular scientific field is referred to as a ;black swan;, and the most highly-cited papers previously published in the same field ;white swans;. Important scientific progress occurs when ;white swans; meet a ;black swan;, and the citation patterns of the ;white swans; change. This metaphor combines scientific discoveries and scientometric data and suggests that breakthrough scientific discoveries are either ;black swans; or ;grey-black swans;.

  12. Design and operation problems related to water curtain system for underground water-sealed oil storage caverns

    Directory of Open Access Journals (Sweden)

    Zhongkui Li

    2016-10-01

    Full Text Available The underground water-sealed storage technique is critically important and generally accepted for the national energy strategy in China. Although several small underground water-sealed oil storage caverns have been built in China since the 1970s, there is still a lack of experience for large-volume underground storage in complicated geological conditions. The current design concept of water curtain system and the technical instruction for system operation have limitations in maintaining the stability of surrounding rock mass during the construction of the main storage caverns, as well as the long-term stability. Although several large-scale underground oil storage projects are under construction at present in China, the design concepts and construction methods, especially for the water curtain system, are mainly based on the ideal porosity medium flow theory and the experiences gained from the similar projects overseas. The storage projects currently constructed in China have the specific features such as huge scale, large depth, multiple-level arrangement, high seepage pressure, complicated geological conditions, and high in situ stresses, which are the challenging issues for the stability of the storage caverns. Based on years' experiences obtained from the first large-scale (millions of cubic meters underground water-sealed oil storage project in China, some design and operation problems related to water curtain system during project construction are discussed. The drawbacks and merits of the water curtain system are also presented. As an example, the conventional concept of “filling joints with water” is widely used in many cases, as a basic concept for the design of the water curtain system, but it is immature. In this paper, the advantages and disadvantages of the conventional concept are pointed out, with respect to the long-term stability as well as the safety of construction of storage caverns. Finally, new concepts and principles

  13. Risk-Based Two-Stage Stochastic Optimization Problem of Micro-Grid Operation with Renewables and Incentive-Based Demand Response Programs

    Directory of Open Access Journals (Sweden)

    Pouria Sheikhahmadi

    2018-03-01

    Full Text Available The operation problem of a micro-grid (MG in grid-connected mode is an optimization one in which the main objective of the MG operator (MGO is to minimize the operation cost with optimal scheduling of resources and optimal trading energy with the main grid. The MGO can use incentive-based demand response programs (DRPs to pay an incentive to the consumers to change their demands in the peak hours. Moreover, the MGO forecasts the output power of renewable energy resources (RERs and models their uncertainties in its problem. In this paper, the operation problem of an MGO is modeled as a risk-based two-stage stochastic optimization problem. To model the uncertainties of RERs, two-stage stochastic programming is considered and conditional value at risk (CVaR index is used to manage the MGO’s risk-level. Moreover, the non-linear economic models of incentive-based DRPs are used by the MGO to change the peak load. The numerical studies are done to investigate the effect of incentive-based DRPs on the operation problem of the MGO. Moreover, to show the effect of the risk-averse parameter on MGO decisions, a sensitivity analysis is carried out.

  14. Breakthrough: The Career Woman's Guide to Shattering the Glass Ceiling.

    Science.gov (United States)

    Flanders, Margaret L.

    This practical guide for all working women shows the reader how to recognize the barriers likely to confront her and to find the most effective way of breaking through. Chapter 1 summarizes causes of the glass ceiling and provides pointers on recognizing which situations are likely to cause problems. Chapter 2 helps the reader to understand her…

  15. On the completeness of systems of eigenfunctions of the Sturm-Liouville operator with a potential depending on the spectral parameter and a nonlinear problem

    International Nuclear Information System (INIS)

    Zhidkov, P.E.

    1996-01-01

    First, the eigenvalue problem on the segment [0,1] for the Sturm-Liouville operator with a potential depending on the spectral parameter with the zero Dirichlet boundary conditions is considered. For this problem, under some hypotheses on the potential, it is proved that the necessary and sufficient condition for an arbitrary system of eigenfunctions, possessing a unique function with n roots in the interval (0,1) for an arbitrary non-negative integer number n, being complete in the space L 2 (0,1) is the linear independence of the functions from this system in the space L 2 (0,1). Then, this result is applied to the investigation of an eigenvalue problem for a nonlinear operator on the Sturm-Liouville type. For this problem, the completeness of the system of its eigenfunctions in the space L 2 (0,1) is proved. (author). 12 refs

  16. The Neustadt-Glewe geothermal project - problems and experience during operation; Das Geothermieprojekt Neustadt-Glewe - Probleme und Erfahrungen mit einer laufenden Anlage

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, H [Erdwaerme Neustadt-Glewe GmbH (Germany)

    1997-12-01

    The scope and goals of the project and the principle of the Neustadt-Glewe geothermal system are presented. The system was commissioned in February 1995, so that sufficient performance data and availability information are now available. Problems that occurred are described and analyzed. Preliminary analyses of the consumption-dependent cost and cost distribution provide a basis for statements on the economic efficiency of geothermal projects. (orig.) [Deutsch] Es werden Inhalt und Ziel des Projektes, sowie das Prinzip der Geothermienutzung in Neustadt-Glewe kurz dargestellt. Nachdem die Anlage im Februar 1995 in Betrieb ging, koennen erste Betriebsergebnisse und Zuverlaessigkeitsaussagen gegeben werden. Es werden Probleme beim Betrieb der Anlagen geschildert und analysiert. Erste Analysen fuer die verbrauchsabhaengigen Kosten und die Kostenverteilung bilden die Grundlage fuer Aussagen zur Wirtschaftlichkeit derartiger Projekte. (orig.)

  17. A classical Perron method for existence of smooth solutions to boundary value and obstacle problems for degenerate-elliptic operators via holomorphic maps

    Science.gov (United States)

    Feehan, Paul M. N.

    2017-09-01

    We prove existence of solutions to boundary value problems and obstacle problems for degenerate-elliptic, linear, second-order partial differential operators with partial Dirichlet boundary conditions using a new version of the Perron method. The elliptic operators considered have a degeneracy along a portion of the domain boundary which is similar to the degeneracy of a model linear operator identified by Daskalopoulos and Hamilton [9] in their study of the porous medium equation or the degeneracy of the Heston operator [21] in mathematical finance. Existence of a solution to the partial Dirichlet problem on a half-ball, where the operator becomes degenerate on the flat boundary and a Dirichlet condition is only imposed on the spherical boundary, provides the key additional ingredient required for our Perron method. Surprisingly, proving existence of a solution to this partial Dirichlet problem with ;mixed; boundary conditions on a half-ball is more challenging than one might expect. Due to the difficulty in developing a global Schauder estimate and due to compatibility conditions arising where the ;degenerate; and ;non-degenerate boundaries; touch, one cannot directly apply the continuity or approximate solution methods. However, in dimension two, there is a holomorphic map from the half-disk onto the infinite strip in the complex plane and one can extend this definition to higher dimensions to give a diffeomorphism from the half-ball onto the infinite ;slab;. The solution to the partial Dirichlet problem on the half-ball can thus be converted to a partial Dirichlet problem on the slab, albeit for an operator which now has exponentially growing coefficients. The required Schauder regularity theory and existence of a solution to the partial Dirichlet problem on the slab can nevertheless be obtained using previous work of the author and C. Pop [16]. Our Perron method relies on weak and strong maximum principles for degenerate-elliptic operators, concepts of

  18. Breakthroughs in Low Profile Leaky Wave HPM Antennas

    Science.gov (United States)

    2016-10-17

    It is important to note that separate, previous, experimental work has validated the VSWR, gain, patterns, and HPM-class peak power capability in...capable LWA to be developed and was validated experimentally at AFRL/RDH (KAFB, NM) in operation with an HPM source. This led to increased awareness...individual channels are properly in phase at the aperture; embarrassing errors are easily avoidable by diligently following along the waveguide

  19. Comparison of problems and experience of core operation with distorted fuel element assemblies in VVER-1000 and PWR reactors

    International Nuclear Information System (INIS)

    Afanas'ev, A.

    1999-01-01

    The main reactors leading to distortion of fuel element assemblies during reactor operation were studied. A series of actions which compensate this effect was proposed. Criteria of operation limitation in VVER-1000 and PWR reactors are described

  20. Modeling Breakthrough Curves of Citric Acid Adsorption onto Anionic Resins in an Aqueous Solution

    Directory of Open Access Journals (Sweden)

    Sohrabali Ghorbanian

    2015-01-01

    Full Text Available Breakthrough curves for citric acid adsorption from aqueous solution onto ion-exchange resin at 20, 35, and 55°C have been investigated. To predict breakthrough curves, three mathematical models have been analyzed based on the values of the least square method parameters, Durbin-Watson test, and mean relative percent error and, finally, appropriate models have been achieved. Models are in good agreement with experimental data based on the results. To examine models reliabilities and accuracy, models have been compared by various breakthrough curve data obtained by other investigators. The results show appropriate agreement and in some cases regression errors have been reduced to less than 1.0 percent.

  1. Liquid water breakthrough location distances on a gas diffusion layer of polymer electrolyte membrane fuel cells

    Science.gov (United States)

    Yu, Junliang; Froning, Dieter; Reimer, Uwe; Lehnert, Werner

    2018-06-01

    The lattice Boltzmann method is adopted to simulate the three dimensional dynamic process of liquid water breaking through the gas diffusion layer (GDL) in the polymer electrolyte membrane fuel cell. 22 micro-structures of Toray GDL are built based on a stochastic geometry model. It is found that more than one breakthrough locations are formed randomly on the GDL surface. Breakthrough location distance (BLD) are analyzed statistically in two ways. The distribution is evaluated statistically by the Lilliefors test. It is concluded that the BLD can be described by the normal distribution with certain statistic characteristics. Information of the shortest neighbor breakthrough location distance can be the input modeling setups on the cell-scale simulations in the field of fuel cell simulation.

  2. Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.

    Science.gov (United States)

    Murray, Anna; Bennett, Claire E; Perry, John R B; Weedon, Michael N; Jacobs, Patricia A; Morris, Danielle H; Orr, Nicholas; Schoemaker, Minouk J; Jones, Michael; Ashworth, Alan; Swerdlow, Anthony J

    2011-01-01

    Women become infertile approximately 10 years before menopause, and as more women delay childbirth into their 30s, the number of women who experience infertility is likely to increase. Tests that predict the timing of menopause would allow women to make informed reproductive decisions. Current predictors are only effective just prior to menopause, and there are no long-range indicators. Age at menopause and early menopause (EM) are highly heritable, suggesting a genetic aetiology. Recent genome-wide scans have identified four loci associated with variation in the age of normal menopause (40-60 years). We aimed to determine whether theses loci are also risk factors for EM. We tested the four menopause-associated genetic variants in a cohort of approximately 2000 women with menopause≤45 years from the Breakthrough Generations Study (BGS). All four variants significantly increased the odds of having EM. Comparing the 4.5% of individuals with the lowest number of risk alleles (two or three) with the 3.0% with the highest number (eight risk alleles), the odds ratio was 4.1 (95% CI 2.4-7.1, P=4.0×10(-7)). In combination, the four variants discriminated EM cases with a receiver operator characteristic area under the curve of 0.6. Four common genetic variants identified by genome-wide association studies, had a significant impact on the odds of having EM in an independent cohort from the BGS. The discriminative power is still limited, but as more variants are discovered they may be useful for predicting reproductive lifespan.

  3. Ionic Liquids: Breakthrough Absorption Technology for Post-Combustion CO{sub 2} Capture

    Energy Technology Data Exchange (ETDEWEB)

    Maginn, Edward

    2012-09-30

    This is the final report for DE-FC26-07NT43091 Ionic Liquids: Breakthrough Absorption Technology for Post-Combustion CO{sub 2} Capture. A detailed summary is provided of the ionic liquid (IL) discovery process, synthesis and testing results, process / systems modeling, lab-scale operational testing, corrosion testing and commercialization possibilities. The work resulted in the discovery of a new class of ionic liquids (ILs) that efficiently react with CO{sub 2} in a 1:1 stoichiometry with no water present and no increase in viscosity. The enthalpy of reaction was tuned to optimize process economics. The IL was found to have excellent corrosion behavior with and without CO{sub 2} present. In lab-scale tests, the IL was able to effectively remove CO{sub 2} from a simulated flue gas stream, although mass transfer was slower than with aqueous monoethanolamine (MEA) due to higher viscosities. The non-volatile nature of the solvent and its high thermal stability, however, make it an intriguing option. An independent systems analysis indicates that the economics of using the best IL discovered to date (NDIL0157), are at least comparable to and potentially slightly better than - the Fluor Econamine FG PlusTM process (DOE Case 12). Further work should be directed at improving mass transfer / lowering viscosity and developing commercial synthesis routes to make these ILs at scale in an inexpensive manner. Demonstration of the process at larger scales is also warranted, as is the exploration of other process configurations that leverage the anhydrous nature of the solvent and its extremely low volatility.

  4. Column dynamic studies and breakthrough curve analysis for Cd(II) and Cu(II) ions adsorption onto palm oil boiler mill fly ash (POFA).

    Science.gov (United States)

    Aziz, Abdul Shukor Abdul; Manaf, Latifah Abd; Man, Hasfalina Che; Kumar, Nadavala Siva

    2014-01-01

    This paper investigates the adsorption characteristics of palm oil boiler mill fly ash (POFA) derived from an agricultural waste material in removing Cd(II) and Cu(II) from aqueous solution via column studies. The performance of the study is described through the breakthrough curves concept under relevant operating conditions such as column bed depths (1, 1.5, and 2 cm) and influent metal concentrations (5, 10, and 20 mg/L). The Cd(II) and Cu(II) uptake mechanism is particularly bed depth- and concentration-dependant, favoring higher bed depth and lower influent metal concentration. The highest bed capacity of 34.91 mg Cd(II)/g and 21.93 mg Cu(II)/g of POFA was achieved at 20 mg/L of influent metal concentrations, column bed depth of 2 cm, and flow rate of 5 mL/min. The whole breakthrough curve simulation for both metal ions were best described using the Thomas and Yoon–Nelson models, but it is apparent that the initial region of the breakthrough for Cd(II) was better described using the BDST model. The results illustrate that POFA could be utilized effectively for the removal of Cd(II) and Cu(II) ions from aqueous solution in a fixed-bed column system.

  5. The problem of maintenance of strength, lifetime and safety of the structural components operational NPP from items of a system approach

    International Nuclear Information System (INIS)

    Getman, A.F.

    2005-01-01

    The strength of the structural components and pipelines NPP determines largely their lifetime, radiation and nuclear safety. As shows world experience of operation NPP, in a series of cases during operation the local damages, breaks and destructions of elements of the equipment and pipelines emerge. These cases force maintaining organizations to execute on NPP large volumes of the control, repair and modernizing of the equipment and pipelines. These activities require large material inputs (net less than 50% of the cost of operation NPP), however not always are effective and in a series of cases do not allow to reach required of level reliability and safety. The reason of such condition of a problem is that the measures executed on NPP, developed on stretch of long time and under influence of the diverse factors. Besides until now there is no unified scientific methodology of a case study of maintenance of strength, lifetime and safety of the operational equipment and pipelines NPP. The application of a system approach to a problem of maintenance of strength, lifetime and safety of the equipment and pipelines operational NPP allows to consider a problem as a whole, from unified items, to define the most fast and effective paths it of the solution and to decide problems in as much as possible short times at minimum material inputs. The experience of practical application of a system approach at the solution of separate problems of operation NPP has allowed to develop a lot of effective new techniques, technologies and means, which application allows essentially to increase reliability and gamma percentage lifetime of elements NPP, to which they were applied. As an example in the report the outcomes of application of a system approach for maintenance of SG tubes integrity of reactors of a type WWER are adduced. The application of a system approach for all elements of the equipment and pipelines NPP will allow to increase it reliability and safety not less, than on 10

  6. Breakthrough properties of chloride ions in columns of lead phosphate hydroxide

    International Nuclear Information System (INIS)

    Akiba, Kenichi; Hashimoto, Hiroyuki; Mimura, Hitoshi; Shindo, Manabu.

    1994-01-01

    Breakthrough properties of chloride ion (Cl - ) have been studied by using columns packed with a granular anion-exchanger of lead phosphate hydroxide (Pb 10 (PO 4 ) 6 (OH) 2 , IXE-1000G). The column utilization of the ratio of breakthrough capacity to total capacity increased with decreasing particle size and increasing temperature. The collection of Cl - from a simulated waste solution was improved by the addition of cation-exchange to IXE-1000G; the adsorption capacity of the column of IXE-1000G/IXE-300G (Sb type cation-exchanger) was over 0.16 mmol Cl - /g, yielding a relatively high column utilization of 75%. (author)

  7. Coupling gravity, electromagnetism and space-time for space propulsion breakthroughs

    Science.gov (United States)

    Millis, Marc G.

    1994-01-01

    spaceflight would be revolutionized if it were possible to propel a spacecraft without rockets using the coupling between gravity, electromagnetism, and space-time (hence called 'space coupling propulsion'). New theories and observations about the properties of space are emerging which offer new approaches to consider this breakthrough possibility. To guide the search, evaluation, and application of these emerging possibilities, a variety of hypothetical space coupling propulsion mechanisms are presented to highlight the issues that would have to be satisfied to enable such breakthroughs. A brief introduction of the emerging opportunities is also presented.

  8. Elusive prize: enormous coal gas potential awaits production technology breakthrough

    Energy Technology Data Exchange (ETDEWEB)

    Collison, M.

    2002-01-07

    The expanded gas pipeline grid has excess capacity, and gas resources are declining. There is increasing interest in development of Canada's resources of coalbed methane (CBM). The chairman of the Canadian Coalbed Methane Forum estimates that Canada has more than 3,000 trillion ft{sup 3} of gas awaiting suitable technology. PanCanadian and MGV Energy conducted a CBM exploration and pilot study on the Palliser spread in southern Alberta. Results from 23 of 75 wells are encouraging. The study is being accelerated and expanded to include an additional 50 wells elsewhere in Alberta. Some scientists anticipate commercial CBM production within two years. Problems facing developers include the large land holdings necessary for economic CBM production and the disposal of coal formation water. It is anticipated that U.S. technology will be modified and used. The potential for CBM development at Pictou in Nova Scotia and in British Columbia in the foothills is considered. 3 figs.

  9. [An approach to DSM-5: a breakthrough in psychiatry?].

    Science.gov (United States)

    Heerlein, Andrés L

    2014-01-01

    One of the main problems of current psychiatry is that its diagnostic classification systems are not precise and reliable, they do not help to identify with certainty a specific type of mental disorder and they frequently overlap two or more diagnoses. This may conduce to over diagnosis and overtreatment, which is the main criticism of the DSM system. The American Psychiatric Association (APA) launched recently the DSM-5, the fifth edition of its diagnostic manual, which provides diagnostic criteria for thousands of psychiatrist, psychologist and researchers and who will be using it in the next coming years. DSM-5, like the preceding editions, placed disorders in discrete categories such as bipolar disorder or schizophrenia. The problem is that scientists have been unable to find yet a genetic or neurobiological evidence to support the theory of mental disorders as separate categories. Several authors wanted the latest DSM to move away from the category model towards a new "dimensional approach", where disorders can be measured and mental illnesses overlapping can be reduced. Recent findings supports this new dimensional strategy, suggesting that the disorders are a product of shared risk factors that lead to abnormalities in specific drives, which can be measured and used to place persons on one of several spectra. In some parts the DSM-5 entered changes aiming to achieve a greater objectivity. The door for new changes in each category, dimension or criteria has been opened, favoring an evidence-based development of the future versions. DSM-5 is presented as a "living document" that can be updated easily. However, the category model still remains for many disorders. The future research in psychiatric diagnostic systems requires more genetic-molecular and neurophysiological evidence and more objective multinational field trials, in order to confirm the existence of the new diagnostic entities, spectrums or dimensions. This approach may provide us reliable

  10. Modernization Breakthrough: Search for Innovations at the Comprador Market

    Directory of Open Access Journals (Sweden)

    Sidorov Viktor Aleksandrovich

    2014-11-01

    Full Text Available Formation of the economy based on a new technological basis, a new cycle of scientific and technical progress, suggests the involvement of the innovative development factors. Among these new techniques we should mention technology, organization and motivation of labor, qualified labor force, management innovation, intellectual potential. This, in turn, implies broad development of inventions, the appearance of the pioneer and major inventions, the formation of innovation as well as their distribution. The article deals with the problem of the susceptibility of the Russian economy to innovative production methods. The authors examine the socio-economic background of modernization of the national economy. It is proved that the human capital plays special role in the use, development and coordination of innovative growth factors. The problems of formation and development of human capital in modern Russia are discussed. The necessity of forming and analyzing the indicators of social capital in the country, which takes into account the socio-political stability, law and order, protection from corruption, income differentiation, mutual trust. A critical analysis of the most important indicators of innovation activity of enterprises, allows to identify the factors that promote and prevent its increase. It is proved that a low level of innovation activity of enterprises due to inadequate funding of science and education, and the sharp differences in income inequality hamper the development of the infrastructure of the innovation process. The authors disclose the role of start-ups, as an effective framework for the implementation of innovations and objectify the parameters of economic growth suggesting to concentrate resources on innovation.

  11. Problems in Operating a Drug Rehabilitation Center in an Adult Correctional Setting and Some Preventive Guidelines or Strategies.

    Science.gov (United States)

    Smith, S. Mae; And Others

    1979-01-01

    Some of the problems include differences in philosophy, nontherapeutic aspects of the prison environment, dependency on the prison environment, and unique staff problems. The authors conclude that changes can be made and effective treatment can exist within the correctional setting. (Author)

  12. Stress at Work and Its Subsequent Problems among Teachers of the Public Schools Which Operate the School-Based Violence Reduction Program (VRP) in Tulkarm Governorate

    Science.gov (United States)

    Oteer, Rabee

    2015-01-01

    This study aimed to identify the work-related stress and its subsequent problems among teachers of the public schools which operated the school-based Violence Reduction Program (VRP) in the governorate of Tulkarm during the second semester of 2015-2016. Besides, it aimed to identify the effect of specific variables, such as gender, specialization,…

  13. A New Result Concerning the Solvability of a Class of General Systems of Variational Equations with Nonmonotone Operators: Applications to Dirichlet and Neumann Nonlinear Problems

    Directory of Open Access Journals (Sweden)

    Luisa Toscano

    2016-01-01

    Full Text Available A new result of solvability for a wide class of systems of variational equations depending on parameters and governed by nonmonotone operators is found in a Banach real and reflexive space with applications to Dirichlet and Neumann problems related to nonlinear elliptic systems.

  14. Cognitive Skills Used to Solve Mathematical Word Problems and Numerical Operations: A Study of 6- to 7-Year-Old Children

    Science.gov (United States)

    Bjork, Isabel Maria; Bowyer-Crane, Claudine

    2013-01-01

    This study investigates the relationship between skills that underpin mathematical word problems and those that underpin numerical operations, such as addition, subtraction, division and multiplication. Sixty children aged 6-7 years were tested on measures of mathematical ability, reading accuracy, reading comprehension, verbal intelligence and…

  15. The solarPACES strategy for the solar thermal breakthrough

    International Nuclear Information System (INIS)

    Burch, G.D.; Grasse, W.

    1997-01-01

    IEA(International Energy Agency)/SolarPACES(Solar Power and Chemical Energy systems)represents a world wide coalition for information sharing and collaboration on applications of concentrated solar energy. The current SolarPACES community has built up solar thermal system know-how over 15 years, is operating the three main solar test centres in the world. Its main activities are in the following four fields: solar thermal electric power systems, solar chemistry, solar technology and advanced applications and non-technical activities. The article presents the talk on the strategy of solarPACES given at the International Workshop on applied solar energy held in Tashkent(Uzbekistan) in June 1997. (A.A.D.)

  16. The Top Ten Astronomical 'breakthroughs' of the 20th century

    Directory of Open Access Journals (Sweden)

    Hughes, D. W.

    2007-10-01

    Full Text Available Astronomy was revolutionized in the 20th century. The electron was discovered in 1897 and this transformed spectroscopy and introduced plasma and magnetohydrodynamic physics and astro-chemistry. Einstein’s E = mc2, solved the problem of stellar energy generation and spawned the study of elemental nuclear synthesis. Large telescopes led to a boom in astronomical spectroscopic and photometric data collection, leading to such cornerstones as the Hertzprung-Russell diagram and the mass-luminosity relationship, and to the realization that the Universe contained a multitude of galaxies and was expanding. Radio astronomy was introduced and the advent of the space age saw the astronomical wavelength range expand into the ultraviolet, X-ray and gamma-ray regions, as well as the infrared and millimetre. We also startedwandering around roaming the Solar System instead of merely glimpsing its members from the bottom of our warm, turbulent atmosphere. Astronomical “breakthroughs” abounded. We have asked astronomers to select their “top ten” and these are listed and discussed in this paper.

  17. Generalized bi-quasi-variational inequalities for quasi-semi-monotone and bi-quasi-semi-monotone operators with applications in non-compact settings and minimization problems

    Directory of Open Access Journals (Sweden)

    Chowdhury Molhammad SR

    2000-01-01

    Full Text Available Results are obtained on existence theorems of generalized bi-quasi-variational inequalities for quasi-semi-monotone and bi-quasi-semi-monotone operators in both compact and non-compact settings. We shall use the concept of escaping sequences introduced by Border (Fixed Point Theorem with Applications to Economics and Game Theory, Cambridge University Press, Cambridge, 1985 to obtain results in non-compact settings. Existence theorems on non-compact generalized bi-complementarity problems for quasi-semi-monotone and bi-quasi-semi-monotone operators are also obtained. Moreover, as applications of some results of this paper on generalized bi-quasi-variational inequalities, we shall obtain existence of solutions for some kind of minimization problems with quasi- semi-monotone and bi-quasi-semi-monotone operators.

  18. POLITICAL RISK ON THE FINANCIAL MARKET The problem of adequate scientific assessment of business operations - the naivety of economists

    Directory of Open Access Journals (Sweden)

    Leszek Dziawgo

    2014-04-01

    Full Text Available One of the significant problems of a modern economy and economics is political risk. A destructive influence of politics on the financial market cannot be ignored. It is necessary to indicate some selected specific problems of the financial market connected with politics in the area of: public finance (including EU, monetary policy and capital market. Nowadays, the scale and dynamics of political interference in the economy and finance leads to the problem of rationality in business activities. Moreover, many hidden political factors change the political risk into immeasurable political uncertainty.

  19. Creative Management as a Strategy for Breakthrough Innovation. Lessons from Basic Research Projects of Japanese Companies.

    Science.gov (United States)

    Lee, K. T.

    1997-01-01

    Japanese science/technology policies emphasize creative research management for strengthening breakthrough innovation. Key lessons include the following: cultivation of creative researchers, clear strategic directions, systematic teamwork and collaboration, focus on strategic industrial relevance, balance between autonomy and control, and the need…

  20. First case of breakthrough pneumonia due to Aspergillus nomius in a patient with acute myeloid leukemia.

    Science.gov (United States)

    Caira, Morena; Posteraro, Brunella; Sanguinetti, Maurizio; de Carolis, Elena; Leone, Giuseppe; Pagano, Livio

    2012-10-01

    We report the first known case of a breakthrough pulmonary infection caused by Aspergillus nomius in an acute myeloid leukemia patient receiving caspofungin therapy. The isolate was identified using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and sequencing-based methods. The organism was found to be fully susceptible, in vitro, to echinocandin antifungal agents.

  1. Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients

    International Nuclear Information System (INIS)

    Ming-Lin Ho; Chih-Yuan Chung

    2010-01-01

    We evaluated the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients. This study was conducted at Changhua Christian Hospital, Changhua, Taiwan from January 2006 to February 2007. The single-center and open-label study enrolled 59 opioid-treated cancer patients with at least moderate breakthrough pain (visual analog scale [VAS] score >/=40mm on a 100-mm scale). The efficacy measures included VAS scores and adverse effect assessment 10, 30, and 60 minutes after the administration of tramadol/acetaminophen. Visual analog scale score at time of pain relief was reported. The mean VAS score when the breakthrough pain episode began (0 minute) was 77.8. Analysis showed significant better mean pain VAS scores at 10, 30, and 60 minutes after the administration of tramadol/acetaminophen (p Tramadol/acetaminophen might be efficacious and safe in the treatment of breakthrough pain in cancer (Author).

  2. Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients.

    Science.gov (United States)

    Ho, Ming-Lin; Chung, Chih-Yuan; Wang, Chuan-Cheng; Lin, Hsuan-Yu; Hsu, Nicholas C; Chang, Cheng-Shyong

    2010-12-01

    We evaluated the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients. This study was conducted at Changhua Christian Hospital, Changhua, Taiwan from January 2006 to February 2007. The single-center and open-label study enrolled 59 opioid-treated cancer patients with at least moderate breakthrough pain (visual analog scale [VAS] score ≥40mm on a 100-mm scale). The efficacy measures included VAS scores and adverse effect assessment 10, 30, and 60 minutes after the administration of tramadol/acetaminophen. Visual analog scale score at time of pain relief was reported. The mean VAS score when the breakthrough pain episode began (0 minute) was 77.8. Analysis showed significant better mean pain VAS scores at 10, 30, and 60 minutes after the administration of tramadol/acetaminophen (p≤0.001 versus 0 min for all 3 time points). The mean time to pain relief was 597.2 seconds and the mean VAS score at time of relief was 43.4. The effective rates, defined by more than 30% reduction of the VAS score, after 10 minutes of administration was 74.6%, 30 minutes 86.4%, and one hour 94.9% (p≤0.001 versus 0 minute for all 3 time points). Two cases of drowsiness were reported. Tramadol/acetaminophen might be efficacious and safe in the treatment of breakthrough pain in cancer.

  3. [Parahisian atrial tachycardia or atrioventricular nodal reentrant tachycardia with tendon of Todaro breakthrough?].

    Science.gov (United States)

    Orczykowski, Michał; Jaworska-Wilczyńska, Maria; Urbanek, Piotr; Bodalski, Robert; Derejko, Paweł; Gajek, Jacek; Hryniewiecki, Tomasz; Szumowski, Lukasz; Walczak, Franciszek

    2010-08-01

    We present a case of a 61 year-old woman with tachycardia originating close to the His bundle where radiofrequency (RF) ablation may bear potential risk of atrioventricular (AV) block. In this case report we discuss the possibility of a AV nodal reciprocating tachycardia with tendon of Todaro breakthrough. Patient was safely and effectively treated with RF catheter ablation.

  4. Power to gas. The final breakthrough for the hydrogen economy?

    Energy Technology Data Exchange (ETDEWEB)

    Winkler-Goldstein, Raphael [Germany Trade and Invest (GTAI), Paris (France); Rastetter, Aline [Alphea Hydrogene, Forbach (France)

    2013-04-01

    storage of extra energy produced by renewable sources. The hydrogen produced via electrolysis could be drawn upon - directly or as synthetic natural gas (SNG) in a second additional methanation process step - to provide electricity by means of CCGT (combined cycle gas turbines) or CHP (combined heat and power) using for example fuel cells. It could also address the industrial and household heat market. DVGW is furthermore participating in the 'Power-to-Gas Platform' that was set up in 2012 by the German Energy Agency, bringing together RnD institutes, renewable energy project developers and park operators, utilities, underground storage providers in order to create political support for this new technology. Demonstration projects will be completed by 2020 in order to develop business models (for storage, production and trade of 'green gas') and devices (electrolysers, turbines, smart gas metering, compressors, storage capacities amongst others) to enable the implementation of this concept on a broad scale. This means that a multitude of industrial players will be involved in the changes that will occur in the value chain: utilities (electricity, gas), power technology companies, car makers, heating device manufacturers, but also manufacturers of measurement, regulation and control devices, suppliers of the biogas and methanation industry. Germany is the pioneer in this field. This technology however increasingly interests its neighbours, with project developments in France, Italy, Spain, and UK but also in North America and North Africa. Germany can contribute its valuable experience (e.g. legal framework for power-to-gas) to the development of these industries. German participants in demonstration projects in these countries could for example be renewable energy park operators, RnD institutes and suppliers. (orig.)

  5. The protection of operating personnel in nuclear power plants against the risk of nuclear incidents and ionizing radiation arising from normal operation of the plant. Rules and problems

    International Nuclear Information System (INIS)

    Ortore, F.; Scalera, D.

    1980-03-01

    After an analysis of the nuclear third party liability insurance policy to be taken out in Italy in implementation of Act no. 1860 of 31 December 1962 and Decree No. 519 of 10 May 1979, the collective policy against radiation injuries taken out for operating personnel in nuclear installations is described. The author is in favour of further harmonization of the legal system presently in force in this respect. (NEA) [fr

  6. Additive for reducing operational problems in waste fired grate boilers; Additiv foer att minska driftproblem vid rostfoerbraenning av avfall

    Energy Technology Data Exchange (ETDEWEB)

    Gyllenhammar, Marianne; Herstad Svaerd, Solvie; Davidsson, Kent; Hermansson, Sven; Liske, Jesper; Larsson, Erik; Jonsson, Torbjoern; Zhao, Dongmei

    2013-09-01

    The combustion of waste implies a risk for deposits and corrosion in different parts of the combustion facility. In recent years, research and tests have been performed in order to find ways to mitigate these problems in waste-fired plants. Most waste-fired plants in Sweden are grates whereas most of the research has been carried out in fluidized bed plants. The purpose of this project is to examine whether co-firing of sewage sludge and waste can reduce deposition and corrosion also in grate-fired boilers as has been shown in fludised beds. The objective is to determine the deposit growth and its composition as well as describing the initial corrosion attack. Representing sulphur-rich waste, elementary sulphur is also added to the waste and thereby compared with sludge as an additive. The target groups for this project are plant owners, researchers, consultants and authorities. Tests were performed in a 15 MWth waste-fired boiler with moving grate at Gaerstadverket, Tekniska Verken (Linkoeping). The boiler produces saturated steam of 17 bars and 207 deg C, and the normal fuel mixture contains of household and industry waste. The results show that co-firing with as heigh as 20 weight-% SLF (25 energy-%) was possible from an operational point of view, but the deposit rate increased especially at the two warmest positions. Generally the deposit rate was highest in the position closest to the boiler and decreased further downstream. During the tests a lot higher amount of SLF than normal was used (recommended mix is 5-10 % of SLF) this to be able to see effects of the different measures. Up to 23 weight-% of the rather moist sewage sludge was possible to fire when co-firing waste and SLF, without addition of oil. By adding sludge the deposit rate decreased but the increase upon adding SLF to ordinary waste was not totally eliminated. In the tests 'Avfall and SLF' the deposits were rich in chlorine. High concentrations of metal chlorides were found in the

  7. Effect of temperature on the breakthrough of a charcoal tube during vinyl chloride monomer sampling.

    Science.gov (United States)

    Roh, J; Park, Y J; Kim, C N; Lim, N G; Lee, S H; Song, J S; Won, J U; Talaska, G

    2000-01-01

    This study evaluated the effects of temperature on breakthrough of two standard collection media at various concentrations during vinyl chloride monomer (VCM) sampling. The National Institute for Occupational Safety and Health (NIOSH) and Occupational Safety and Health Administration (OSHA) methods were evaluated. To determine whether breakthrough of VCM would occur at the extremes of exposure and temperature that might be encountered in some workplaces, air samples containing 4 ppm (10.24 mg/m3), 8 ppm (20.45 mg/m3), 16 ppm (40.98 mg/m3), and 32 ppm (81.80 mg/m3) of VCM were collected at temperatures of 4, 22, and 40 degrees C. Five liters of air was sampled at the rate of 0.05 L/min for 100 min using the activated charcoal tube recommended by NIOSH. A second tube was added to the sampling train to collect any VCM that might not have been absorbed in the first tube. To collect VCM air samples by the OSHA method, two carbon molecular sieve tubes were connected serially and 3 L of air was sampled at the rate of 0.05 L/min for 60 min. A gas chromatograph with a flame ionization detector and ultra 2 capillary column was used to analyze VCM. Significant breakthrough was found when sampling at higher temperatures with the NIOSH method. No breakthrough was found when samples were collected using the OSHA media at different temperatures and concentrations. Therefore, under hot ambient conditions (>22 degrees C), the possibility of breakthrough should be considered when sampling VCM by the NIOSH method.

  8. Distal Ureteral Diameter Ratio is Predictive of Breakthrough Febrile Urinary Tract Infection.

    Science.gov (United States)

    Arlen, Angela M; Leong, Traci; Guidos, P Joseph; Alexander, Siobhan E; Cooper, Christopher S

    2017-12-01

    Distal ureteral diameter ratio is an objective measure that is prognostic of spontaneous resolution of vesicoureteral reflux. Along with likelihood of resolution, improved identification of children at risk for recurrent febrile urinary tract infections may impact management decisions. We evaluated the usefulness of ureteral diameter ratio as a predictive factor for breakthrough febrile urinary tract infections. Children with primary vesicoureteral reflux and detailed voiding cystourethrogram were identified. Ureteral diameter ratio was computed by measuring largest ureteral diameter within the pelvis and dividing by the distance between L1 and L3 vertebral bodies. Demographics, vesicoureteral reflux grade, laterality, presence/absence of bladder-bowel dysfunction, and ureteral diameter ratio were tested in univariate and multivariable analyses. Primary outcome was breakthrough febrile urinary tract infections. We analyzed 112 girls and 28 boys with a mean ± SD age of 2.5 ± 2.3 years at diagnosis. Vesicoureteral reflux was grade 1 to 2 in 64 patients (45.7%), grade 3 in 50 (35.7%), grade 4 in 16 (11.4%) and grade 5 in 10 (7.2%). Mean ± SD followup was 3.2 ± 2.7 years. A total of 40 children (28.6%) experienced breakthrough febrile urinary tract infections. Ureteral diameter ratio was significantly greater in children with (0.36) vs without (0.25) breakthrough febrile infections (p = 0.004). Controlling for vesicoureteral reflux grade, every 0.1 U increase in ureteral diameter ratio resulted in 1.7 times increased odds of breakthrough infection (95% CI 1.24 to 2.26, p urinary tract infections independent of reflux grade. Ureteral diameter ratio provides valuable prognostic information about risk of recurrent pyelonephritis and may assist with clinical decision-making. Copyright © 2017 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  9. A survey of Canadian cancer patients' perspectives on the characteristics and treatment of breakthrough pain.

    Science.gov (United States)

    Bedard, Gillian; Hawley, Philippa; Zhang, Liying; Slaven, Marissa; Gagnon, Pierre; Bisland, Stuart; Bennett, Margaret; Tardif, Francois; Chow, Edward

    2013-09-01

    Breakthrough pain is defined as a transient exacerbation of pain that occurs spontaneously or in response to a trigger despite stable and controlled background pain. The purpose of this study was to explore Canadian patients' awareness of and experience with breakthrough pain in cancer (BTPc). Four Canadian cancer centers participated in a non-interventional survey recruiting cancer patients who experienced breakthrough pain. These patients were asked about their pain, its impact on functioning, current management and interest in new treatments of BTPc. Ninety-four Canadian cancer patients participated in this study, with 96% stating that cancer pain impacted their daily living with over half unable to go to work or shopping. Fifty percent of patients said that an episode of BTPc lasted greater than 60 minutes, with the pain score being on average 7.8/10, impacting normal work (7.2/10) and general activity (7.1/10). Only 35% of patients were very satisfied with the speed of relief of their medications. Those who did not take their breakthrough pain medication for every episode stated that was because the pain was not always severe (37%), or they were afraid of becoming tolerant (23%) or addicted (12%). Patients stated that the most important features of a new treatment for BTPc were the ability to relieve pain completely (47%), and quickly (43%). Patients expressed willingness to try transmucosal products (80%) or nasal products (59%). Breakthrough cancer pain in Canadian cancer patients greatly impacts their daily lives. There is room for improvement in the management of BTPc, and the majority of patients would be willing to try new treatments.

  10. Operating experience and radiation protection problems in the working of the radio-metallurgy hot cell facilities at BARC

    International Nuclear Information System (INIS)

    Janardhanan, S.; Watamwar, S.B.; Mehta, S.K.; Pillai, P.M.B.; John, Jacob; Kutty, K.N.

    1977-01-01

    The Bhabha Atomic Research Centre at Bombay has six hot cell facilities for radiometallurgical investigations of irradiated/failed fuel elements. The hot cell facilities have been provided with certain built-in safety features, a ventilation system, radiation monitoring instruments for various purposes, a centralised air monitoring system and a central panel for display of various alarms. Procedures adopted for radiation protection and contamination control include : (1) radiation leak test for cells and filter efficiency evaluation before cell activation, (2) practices to be followed by frog suit personnel while working in hot cell areas, (3) receipt and handling of irradiated fuel elements, (4) cell filter change operation, (5) checks on high level drains and (6) effluent discharge and waste shipments. Operating experience in the working of these facilities along with radiation accident incidents is described. Data regarding release of activity during normal cell operations, dose rates during various metallurgical operations and personnel exposures are presented. (M.G.B.)

  11. Certain problems in the economics of deep drilling operations conducted in the Chechen-Ingush Autonomous Soviet Socialist Republic

    Energy Technology Data Exchange (ETDEWEB)

    Umanskiy, L.M.; Repina, I.S.

    1981-01-01

    The authors provide analysis and evaluation of technical-economic indicators for borehole drilling conducted at great depths in the Chechen-Ingush Autonomous Republic. Suggestions are made for improving such drilling operations in this area.

  12. Present Situation and Problems of Land Improvement District as an Operation and Maintenance Organization of Land Improvement Facilities

    OpenAIRE

    長堀, 金造; 赤江, 剛夫; 大田, 征六

    1994-01-01

    Land improvement districts originally started as organizations after World War II: They are in charge of construction and operation of irrigation and drainage facilities, Development of agricultural land, reclamation from sea water, reclamation by filling, Recovery from disaster, exchange and consolidation of agricultural land and so on. As the Main construction projects were completed, the purpose of land improvement districts Has shifted from facilities construction to operation and mainten...

  13. Problems of economic assessment of social impacts of construction anO operation of nuctear power plant in the area

    International Nuclear Information System (INIS)

    Koudelka, F.

    1984-01-01

    The impacts of nuclear power plant construction and operation are divided into economic, demographic, on town planning, historic, etc. Further subdivision is performed according to the intensity of construction impacts, to the sequence and quality of impact and to the effects in space and time. The area of environmental impacts is classified into the protective area and the areas of immediate, limited and broad impact. The methods of the evaluation of nuclear power plant construction and operation impacts are discussed. (E.S.)

  14. Choreographing Partnerships within an Organizational Structure of Accountability: Maryland State Department of Education's Shift from Compliance Monitor to Breakthrough Partner

    Science.gov (United States)

    Strickling, Laura Rutter; Doneker, Karen Lee

    2014-01-01

    Drawing upon data from twenty-five interviews, this paper examines how the Maryland State Department of Education's Cross-functional Team navigates its changing role from compliance monitor to breakthrough partner in terms of discourse, time, and flexibility, as it carries out the work of the Breakthrough Center. It also examines how the role of…

  15. EXTEND OPERATION PROBLEMS AND RECONSTRUCTION OF LARGEPANEL FIVE-STOREY BUILDINGS OF 50-60-IES XX CENTURY

    Directory of Open Access Journals (Sweden)

    BOLSHAKOV V. I.,

    2016-01-01

    Full Text Available Raising of the problem. In many regions is utilised housing, that age is more than half a century. According to the research materials of the analytical center of Ukrainian Cities Association there are 25,5 thousand houses built by first mass series project of large, block and brick buildings with a total area of 72 million M2 today in the state, rather those, that require reconstruction and modernization. In general, most of the housing stock of Ukraine is in a poor technical condition due to its deficient funding; it keeps the tendency of premature aging of the housing stock.One of the major problems of modern construction industry is the continuation of housing exploitation, in particular is it the building era of mass construction of 50-60-ies of XX century, called "Khrushchevki". According to the State Statistics Service of Ukraine the deterioration of residential buildings in Ukraine amounts to 47.2%, which makes us think of the immediate actions to occure this situation. The most acceptable way, at first viewe, seems the reconstruction of "Khrushchvki". However, the reconstruction is a complex problem that requires the construction industry solution due to the economic component, the social factor, the views of residents of these homes to create a technological and economical viable result. Analysis of publications. The problem of the "Khrushchevki" reconstruction is the subject of continual researches of leading builders of Ukraine. In the researchers' attention just as the technological problems [1 - 3], so economic components [4 - 6], in general, give an idea of the work scale required to overcome the impending crisis. The purpose of the article. Defining the main problems of exploatation of panel fivestory buildings of 50 - 60-ies twentieth century and their residents thoughts about existing inconvenience, as well as associated economic, technological and legal problems in the implementation of buildings reconstruction. Conclusions

  16. A physiological exploration on operational stance and occupational musculoskeletal problem manifestations amongst construction labourers of West Bengal, India.

    Science.gov (United States)

    Chatterjee, Arijit; Sahu, Subhashis

    2018-03-29

    A huge number of labourers engaged in construction industry in India both in organized and unorganized sectors. The construction labourers most often work for an extended period of time and they are compelled to uphold altered static and dynamic operational stance in awkward positions during the complete period of work which raises the demand on the musculoskeletal system and may lead to work related musculoskeletal disorders (WRMSDs). This study is intended to explore the operational stance and occupation related musculoskeletal manifestations amongst the construction labourers. One sixty four male labourers from different construction sites of West Bengal was randomly taken for this study. A modified Nordic questionnaire on MSD and the 12 item General Health Questionnaire (GHQ12) were administered on the construction labourers. Rapid Entire Body Assessment [REBA] and Ovako Work Analysis System [OWAS] methods were applied to analyze the operational stance. Finally, discomfort levels of the specific operational stance were calculated by the use of risk level and BPD scale. From the study it was revealed that most of the construction labourers habitually in awkward operational stance and were affected by altering musculoskeletal manifestations like pain in low back, neck, and wrist. It has been also found that there is a significant (pconstruction labourers in unorganized sectors.

  17. Protection and restoration of soil in mining operations which disrupt the surface of the earth, with the open pit method of working minerals (problems, obtained data and recommendations)

    Energy Technology Data Exchange (ETDEWEB)

    Debelak, M.

    1981-01-01

    A critical analysis is made of the current state and the ways to solve the problem of protection and restoration of the sections of the earth's surface and sources of drinking water which can be disrupted with the open pit method of working minerals. The need is advanced for creating a system of coordination and planning of the activity of all the organizations associated with working minerals, restoration operations and inspection of them. The order of preparation for recultivation during mining operations (in particular, storage of the fertile ground) and conducting them after the end of mining are described.

  18. Performance analysis of the partial use of a local optimization operator on the genetic algorithm for the Travelling Salesman Problem

    Directory of Open Access Journals (Sweden)

    Milan Djordjevic

    2012-01-01

    Full Text Available Background: The Travelling Salesman Problem is an NP-hard problem in combinatorial optimization with a number of practical implications. There are many heuristic algorithms and exact methods for solving the problem. Objectives: In this paper we study the influence of hybridization of a genetic algorithm with a local optimizer on solving instances of the Travelling Salesman Problem. Methods/ Approach: Our algorithm uses hybridization that occurs at various percentages of generations of a genetic algorithm. Moreover, we have also studied at which generations to apply the hybridization and hence applied it at random generations, at the initial generations, and at the last ones. Results: We tested our algorithm on instances with sizes ranging from 76 to 439 cities. On the one hand, the less frequent application of hybridization decreased the average running time of the algorithm from 14.62 sec to 2.78 sec at 100% and 10% hybridization respectively, while on the other hand, the quality of the solution on average deteriorated only from 0.21% till 1.40% worse than the optimal solution. Conclusions: In the paper we have shown that even a small hybridization substantially improves the quality of the result. Moreover, the hybridization in fact does not deteriorate the running time too much. Finally, our experiments show that the best results are obtained when hybridization occurs in the last generations of the genetic algorithm.

  19. Brain Hyper-Connectivity and Operation-Specific Deficits during Arithmetic Problem Solving in Children with Developmental Dyscalculia

    Science.gov (United States)

    Rosenberg-Lee, Miriam; Ashkenazi, Sarit; Chen, Tianwen; Young, Christina B.; Geary, David C.; Menon, Vinod

    2015-01-01

    Developmental dyscalculia (DD) is marked by specific deficits in processing numerical and mathematical information despite normal intelligence (IQ) and reading ability. We examined how brain circuits used by young children with DD to solve simple addition and subtraction problems differ from those used by typically developing (TD) children who…

  20. Practical experience and problems in the inspection work during test and routine operation of nuclear power plants

    International Nuclear Information System (INIS)

    Backstroem, T.

    1977-01-01

    A brief description is given of the Swedish Nuclear Power Inspectorate (SNPI) and its working methods in the field of licensing procedures and inspection activities. SNPI has introduced a system to be kept continuously informed about the operation of the nuclear power plants. This information is used in the preparation work preceding the inspections. Experience obtained from the inspection activities show that inspection frequency has been lower than planned. Documentation can be improved and that good relations between the authority and the utilities, including the operating personnel, is to the benefit of the nuclear safety. (author)

  1. Gas breakthrough and emission through unsaturated compacted clay in landfill final cover

    International Nuclear Information System (INIS)

    Ng, C.W.W.; Chen, Z.K.; Coo, J.L.; Chen, R.; Zhou, C.

    2015-01-01

    Highlights: • Explore feasibility of unsaturated clay as a gas barrier in landfill cover. • Gas breakthrough pressure increases with clay thickness and degree of saturation. • Gas emission rate decreases with clay thickness and degree of saturation. • A 0.6 m-thick clay layer may be sufficient to meet gas emission rate limit. - Abstract: Determination of gas transport parameters in compacted clay plays a vital role for evaluating the effectiveness of soil barriers. The gas breakthrough pressure has been widely studied for saturated swelling clay buffer commonly used in high-level radioactive waste disposal facility where the generated gas pressure is very high (in the order of MPa). However, compacted clay in landfill cover is usually unsaturated and the generated landfill gas pressure is normally low (typically less than 10 kPa). Furthermore, effects of clay thickness and degree of saturation on gas breakthrough and emission rate in the context of unsaturated landfill cover has not been quantitatively investigated in previous studies. The feasibility of using unsaturated compacted clay as gas barrier in landfill covers is thus worthwhile to be explored over a wide range of landfill gas pressures under various degrees of saturation and clay thicknesses. In this study, to evaluate the effectiveness of unsaturated compacted clay to minimize gas emission, one-dimensional soil column tests were carried out on unsaturated compacted clay to determine gas breakthrough pressures at ultimate limit state (high pressure range) and gas emission rates at serviceability limit state (low pressure range). Various degrees of saturation and thicknesses of unsaturated clay sample were considered. Moreover, numerical simulations were carried out using a coupled gas–water flow finite element program (CODE-BRIGHT) to better understand the experimental results by extending the clay thickness and varying the degree of saturation to a broader range that is typical at different

  2. Gas breakthrough and emission through unsaturated compacted clay in landfill final cover

    Energy Technology Data Exchange (ETDEWEB)

    Ng, C.W.W.; Chen, Z.K.; Coo, J.L. [Department of Civil and Environmental Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong Kong); Chen, R., E-mail: chenrui1005@hotmail.com [Shenzhen Key Laboratory of Urban and Civil Engineering for Disaster Prevention and Mitigation, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen 518055 (China); Zhou, C. [Department of Civil and Environmental Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong Kong)

    2015-10-15

    Highlights: • Explore feasibility of unsaturated clay as a gas barrier in landfill cover. • Gas breakthrough pressure increases with clay thickness and degree of saturation. • Gas emission rate decreases with clay thickness and degree of saturation. • A 0.6 m-thick clay layer may be sufficient to meet gas emission rate limit. - Abstract: Determination of gas transport parameters in compacted clay plays a vital role for evaluating the effectiveness of soil barriers. The gas breakthrough pressure has been widely studied for saturated swelling clay buffer commonly used in high-level radioactive waste disposal facility where the generated gas pressure is very high (in the order of MPa). However, compacted clay in landfill cover is usually unsaturated and the generated landfill gas pressure is normally low (typically less than 10 kPa). Furthermore, effects of clay thickness and degree of saturation on gas breakthrough and emission rate in the context of unsaturated landfill cover has not been quantitatively investigated in previous studies. The feasibility of using unsaturated compacted clay as gas barrier in landfill covers is thus worthwhile to be explored over a wide range of landfill gas pressures under various degrees of saturation and clay thicknesses. In this study, to evaluate the effectiveness of unsaturated compacted clay to minimize gas emission, one-dimensional soil column tests were carried out on unsaturated compacted clay to determine gas breakthrough pressures at ultimate limit state (high pressure range) and gas emission rates at serviceability limit state (low pressure range). Various degrees of saturation and thicknesses of unsaturated clay sample were considered. Moreover, numerical simulations were carried out using a coupled gas–water flow finite element program (CODE-BRIGHT) to better understand the experimental results by extending the clay thickness and varying the degree of saturation to a broader range that is typical at different

  3. Eigenvalues and bifurcation for problems with positively homogeneous operators and reaction-diffusion systems with unilateral terms

    Czech Academy of Sciences Publication Activity Database

    Kučera, Milan; Navrátil, J.

    2018-01-01

    Roč. 166, January (2018), s. 154-180 ISSN 0362-546X Institutional support: RVO:67985840 Keywords : global bifurcation * maximal eigenvalue * positively homogeneous operators Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.192, year: 2016 http://www. science direct.com/ science /article/pii/S0362546X17302559?via%3Dihub

  4. Eigenvalues and bifurcation for problems with positively homogeneous operators and reaction-diffusion systems with unilateral terms

    Czech Academy of Sciences Publication Activity Database

    Kučera, Milan; Navrátil, J.

    2018-01-01

    Roč. 166, January (2018), s. 154-180 ISSN 0362-546X Institutional support: RVO:67985840 Keywords : global bifurcation * maximal eigenvalue * positively homogeneous operators Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.192, year: 2016 http://www.sciencedirect.com/science/article/pii/S0362546X17302559?via%3Dihub

  5. Problems of the Starting and Operating of Hydraulic Components and Systems in Low Ambient Temperature (Part IV

    Directory of Open Access Journals (Sweden)

    Jasiński Ryszard

    2017-09-01

    Full Text Available Designers of hydraulically driven machines and devices are obliged to ensure during design process their high service life with taking into account their operational conditions. Some of the machines may be started in low ambient temperature and even in thermal shock conditions (due to delivering hot working medium to cold components. In order to put such devices into operation appropriate investigations, including experimental ones - usually very expensive and time-consuming, are carried out. For this reason numerical calculations can be used to determine serviceability of a hydraulic component or system operating in thermal shock conditions. Application of numerical calculation methods is much less expensive in comparison to experimental ones. This paper presents a numerical calculation method which makes it possible to solve issues of heat exchange in elements of investigated hydraulic components by using finite elements method. For performing the simulations the following data are necessary: ambient temperature, oil temperature, heat transfer coefficient between oil and surfaces of elements, as well as areas of surfaces being in contact with oil. By means of computer simulation method values of clearance between cooperating elements as well as ranges of parameters of correct and incorrect operation of hydraulic components have been determined. In this paper results of computer simulation of some experimentally tested hydraulic components such as axial piston pump and proportional spool valve, are presented. The computer simulation results were compared with the experimental ones and high conformity was obtained.

  6. Post-operative endophthalmitis: the application of hazard analysis critical control points (HACCP) to an infection control problem.

    Science.gov (United States)

    Baird, D R; Henry, M; Liddell, K G; Mitchell, C M; Sneddon, J G

    2001-09-01

    Hazard analysis critical control points (HACCP) is a quality assurance system widely used in the food industry to ensure safety. We adopted the HACCP approach when conventional infection control measures had failed to solve an ongoing problem with an increased incidence of postoperative endophthalmitis, and our ophthalmology unit was threatened with permanent cessation of intraocular surgery. Although time-consuming, the result was an entirely new set of protocols for the care of patients undergoing intraocular surgery, the development of an integrated care pathway, and a comprehensive and robust audit programme, which enabled intraocular surgery to continue in a new spirit of confidence. HACCP methodology has so far been little used in healthcare, but it might be usefully applied to a variety of apparently intractable infection control problems. Copyright 2001 The Hospital Infection Society.

  7. On The Fekete-Szegö Problem for Generalized Class Mα,γ(β Defined By Differential Operator

    Directory of Open Access Journals (Sweden)

    Fethiye Müge SAKAR

    2016-11-01

    Full Text Available In this study the classical Fekete-Szegö problem was investigated. Given f(z=z+a2z2+a3z3+...  to be an analytic standartly normalized function in the open unit disk U={z ∈ C : |z|<1}. For |a3-μa22|, a sharp maximum value is provided through the classes of S*α,γ(β order β and type α under the condition of μ≥1.

  8. Coefficients of singularities and mixed methods for the mixed Dirichlet-Neumann problem for the Stokes operator on a polygon

    International Nuclear Information System (INIS)

    Chettab, M.; Lubuma, M.S.

    1990-08-01

    The behaviour of the weak solution of the Stokes problem on a polygon is considered with emphasis on the maximal regularity of the solution and on global formulae for the coefficients of singularities. This regularity leads to a slow convergent mixed finite element method of fractional order less than one while the use of the above formulae provides better approximations for the solution and for the coefficients. (author). 32 refs

  9. Breakthrough bargaining.

    Science.gov (United States)

    Kolb, D M; Williams, J

    2001-02-01

    Unspoken, subtle parts of a bargaining process--also known as the shadow negotiation--can set the tone for a successful negotiation. Deborah Kolb and Judith Williams, whose book The Shadow Negotiation was the starting point for this article, say there are three strategies businesspeople can use to guide these hidden interactions. Power moves are used when two negotiating parties hold unequal power--for instance, subordinates and bosses; new and existing employees; and people of different races, ages, or genders. These strategies, such as casting the status quo in an unfavorable light, can help parties realize that they must negotiate: they will be better off if they do and worse off if they don't. Process moves affect how negotiation issues are received by both sides in the process, even though they do not address substantive issues. Working outside of the actual bargaining process, one party can suggest ideas or marshal support that can shape the agenda and influence how others view the negotiation. Appreciative moves alter the tone or atmosphere so that a more collaborative exchange is possible. They shift the dynamics of the shadow negotiation away from the adversarial--helping parties to save face--and thus build trust and encourage dialogue. These strategic moves don't guarantee that all bargainers will walk away winners, but they help to get stalled negotiations moving--out of the dark of unspoken power plays and into the light of true dialogue.

  10. Nonlinear perturbations of differential operators with nontrivial kernel and applications to third order periodic boundary value problems

    International Nuclear Information System (INIS)

    Afuwape, A.U.; Omari, P.

    1987-11-01

    This paper deals with the solvability of the nonlinear operator equations in normed spaces Lx=EGx+f, where L is a linear map with possible nontrivial kernel. Applications are given to the existence of periodic solutions for the third order scalar differential equation x'''+ax''+bx'+cx+g(t,x)=p(t), under various conditions on the interaction of g(t,x)/x with spectral configurations of a, b and c. (author). 48 refs

  11. The Energy-Efficient Operation Problem of a Freight Train Considering Long-Distance Steep Downhill Sections

    Directory of Open Access Journals (Sweden)

    Xuan Lin

    2017-06-01

    Full Text Available With the energy consumption rising in rail transport, the railway sector is showing increasing interest in the energy-efficient operation of freight trains. Freight trains require more complicated driving strategies than ordinary passenger trains do due to their heavy loads, especially in the long-distance steep downhill (LDSD sections that are very common in freight rail lines in China. This paper studies the energy-efficient operation of a freight train considering LDSD sections. An optimal control model including regenerative and pneumatic braking is developed for the freight train. Then, when a train leaves/enters the LDSD section, we verify the uniqueness of control transitions and discuss the speed profile linkage between LDSD and its adjacent sections, which indicates that the periodic braking should be applied on LDSD sections for optimality. Additionally, given the same running time for the entire journey, our analysis shows that electrical braking-full braking strategy is more energy-efficient than coasting-full braking strategy on LDSD sections. Finally, a numerical algorithm for the optimal driving solution is proposed. The simulation results demonstrate that the driving strategies generated by the proposed algorithm performs better than those from fuzzy predictive control and field operation regarding energy saving.

  12. Mathematical models applied to the Cr(III) and Cr(VI) breakthrough curves.

    Science.gov (United States)

    Ramirez C, Margarita; Pereira da Silva, Mônica; Ferreira L, Selma G; Vasco E, Oscar

    2007-07-19

    Trivalent and hexavalent chromium continuous biosorption was studied using residual brewer Saccharomyces cerevisiae immobilized in volcanic rock. The columns used in the process had a diameter of 4.5 cm and a length of 140 cm, working at an inlet flow rate of 15 mL/min. Breakthrough curves were used to study the yeast biosorption behavior in the process. The saturation time (ts) was 21 and 45 h for Cr(III) and Cr(VI), respectively, and a breakthrough time (tb) of 4 h for Cr(III) and 5 h for Cr(VI). The uptake capacity of the biosorbent for Cr(III) and Cr(VI) were 48 and 60 mg/g, respectively. Two non-diffusional mathematical models with parameters t0 and sigma were used to adjust the experimental data obtained. Microsoft Excel tools were used for the mathematical solution of the two parameters used.

  13. Electrical breakthrough effect for end pointing in 90 and 45 nm node circuit edit

    International Nuclear Information System (INIS)

    Liu, Kun; Soskov, Alex; Scipioni, Larry; Bassom, Neil; Sijbrandij, Sybren; Smith, Gerald

    2006-01-01

    The interaction between high-energy Ga + ions and condensed matter is studied for circuit edit applications. A new 'electrical breakthrough effect' due to charging of, and Ga + penetration/doping into, dielectrics is discovered. This new effect is proposed for end pointing in 90 and 45 nm node circuit edits where integrated circuit device dimensions are of a few hundred nanometers. This new end point approach is very sensitive, reliable, and precise. Most importantly, it is not sensitive to device dimensions. A series of circuit edits involving milling holes of high aspect ratio (5-30) and small cross-section area (0.01-0.25 μm 2 ) on real chips has been successfully performed using the electrical breakthrough effect as the end point method

  14. Breakthrough of toluene vapours in granular activated carbon filled packed bed reactor

    International Nuclear Information System (INIS)

    Mohan, N.; Kannan, G.K.; Upendra, S.; Subha, R.; Kumar, N.S.

    2009-01-01

    The objective of this research was to determine the toluene removal efficiency and breakthrough time using commercially available coconut shell-based granular activated carbon in packed bed reactor. To study the effect of toluene removal and break point time of the granular activated carbon (GAC), the parameters studied were bed lengths (2, 3, and 4 cm), concentrations (5, 10, and 15 mg l -1 ) and flow rates (20, 40, and 60 ml/min). The maximum percentage removal of 90% was achieved and the maximum carbon capacity for 5 mg l -1 of toluene, 60 ml/min flow rate and 3 cm bed length shows 607.14 mg/g. The results of dynamic adsorption in a packed bed were consistent with those of equilibrium adsorption by gravimetric method. The breakthrough time and quantity shows that GAC with appropriate surface area can be utilized for air cleaning filters. The result shows that the physisorption plays main role in toluene removal.

  15. STRATEGY AND EVALUATION OF THE OPERATION OF QUALITY MANAGEMENT SYSTEMS MEDICAL EDUCATION. THE FIRST MESSAGE. PROBLEM FORMULATION

    Directory of Open Access Journals (Sweden)

    O. P. Mintser

    2015-09-01

    Full Text Available The article is devoted to functioning of the quality management by ISO 9001 standard. The problem of inefficient and non-working systems is pointed out, the causes of their inefficiency are investigated. The phenomenon of simultaneous existence of two parallel management systems: formal quality management system and living systems of managerial decisions making is studied. To study this situation the measure of «efficiency of quality management system» is introduced; further tasks for creating indicators and mechanisms for its evaluation are defined.

  16. Survey of the problems posed by the man-machine interface, as seen from the angle of facility operators

    International Nuclear Information System (INIS)

    Heinbuch, R.

    1995-01-01

    The man-machine interface in nuclear power plants is an area very much influenced by the vigorous progress in computer technology. The paper describes the causes underlying the innovative power in this field and its impacts on the man-machine interface in nuclear power plants. The benefits brought by the advanced computer systems in the design of the man-machine interface as well as the problems posed through application in practice to safety-relevant plant systems are discussed, and examples are given showing the experience accumulated so far, and the significant changes effected in the man-machine interface. (orig.) [de

  17. Ordovician gas exploration breakthrough in the Gucheng lower uplift of the Tarim Basin and its enlightenment

    Directory of Open Access Journals (Sweden)

    Wang Zhaoming

    2014-10-01

    Full Text Available A steady high yield natural gas flow was tapped in the Ordovician strata of Well Gucheng 6 drilled in the Gucheng lower uplift in the Tarim Basin in 2012, marking the discovery of another carbonate gas exploration field after the other two fields in the middle and northern Tarim Basin (the so called Tazhong and Tabei in the industry. The exploration in the Gucheng lower uplift has experienced three stages: the first stage, marine facies clastic exploration from 1995 to 2003, focusing on the Devonian Donghe sandstone lithologic traps, the Silurian overlapping lithologic traps, and the Upper Ordovician shelf slope turbidites; the second stage focusing on the reef shoal carbonate reservoirs from 2003 to 2006, during which oil and gas were first discovered in Well Gucheng 4; the third stage can be divided into two periods, in the first period, deeper insight into interbed karstification reservoir exploration, intense research on tricky seismic issues, selection of favorable zones, and 3D seismic deployment in advance laid a robust foundation for breakthroughs in oil and gas exploration; and during 2009–2012, through an in-depth investigation, Well Gucheng 6 was drilled, bringing about the major breakthrough in oil and gas exploration in this study area. This success proves that the Lower Paleozoic carbonate rocks in the Gucheng area have good geological conditions and broad prospect for oil and gas exploration, which give us enlightenment in three aspects: a. new insight into geologic understanding is the prerequisite of exploration breakthrough; b. addressing bottleneck technologies, and acquiring 3D seismic data are the guarantees of exploration breakthrough; and c. emancipation of mind and persistent exploration are key to the findings in new domains.

  18. Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial.

    Science.gov (United States)

    Edlefsen, Paul T; Rolland, Morgane; Hertz, Tomer; Tovanabutra, Sodsai; Gartland, Andrew J; deCamp, Allan C; Magaret, Craig A; Ahmed, Hasan; Gottardo, Raphael; Juraska, Michal; McCoy, Connor; Larsen, Brendan B; Sanders-Buell, Eric; Carrico, Chris; Menis, Sergey; Kijak, Gustavo H; Bose, Meera; Arroyo, Miguel A; O'Connell, Robert J; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Kaewkungwal, Jaranit; Rerks-Ngarm, Supachai; Robb, Merlin L; Kirys, Tatsiana; Georgiev, Ivelin S; Kwong, Peter D; Scheffler, Konrad; Pond, Sergei L Kosakovsky; Carlson, Jonathan M; Michael, Nelson L; Schief, William R; Mullins, James I; Kim, Jerome H; Gilbert, Peter B

    2015-02-01

    The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE) of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients). A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro). The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021). In particular, site 317 in the third variable loop (V3) overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1) more than did non-signature sites (mean = 0.9) (p analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine efficacy trials for diverse pathogens.

  19. The Effect of Velocity Correlation on the Spatial Evolution of Breakthrough Curves in Heterogeneous Media

    Science.gov (United States)

    Massoudieh, A.; Dentz, M.; Le Borgne, T.

    2017-12-01

    In heterogeneous media, the velocity distribution and the spatial correlation structure of velocity for solute particles determine the breakthrough curves and how they evolve as one moves away from the solute source. The ability to predict such evolution can help relating the spatio-statistical hydraulic properties of the media to the transport behavior and travel time distributions. While commonly used non-local transport models such as anomalous dispersion and classical continuous time random walk (CTRW) can reproduce breakthrough curve successfully by adjusting the model parameter values, they lack the ability to relate model parameters to the spatio-statistical properties of the media. This in turns limits the transferability of these models. In the research to be presented, we express concentration or flux of solutes as a distribution over their velocity. We then derive an integrodifferential equation that governs the evolution of the particle distribution over velocity at given times and locations for a particle ensemble, based on a presumed velocity correlation structure and an ergodic cross-sectional velocity distribution. This way, the spatial evolution of breakthrough curves away from the source is predicted based on cross-sectional velocity distribution and the connectivity, which is expressed by the velocity transition probability density. The transition probability is specified via a copula function that can help construct a joint distribution with a given correlation and given marginal velocities. Using this approach, we analyze the breakthrough curves depending on the velocity distribution and correlation properties. The model shows how the solute transport behavior evolves from ballistic transport at small spatial scales to Fickian dispersion at large length scales relative to the velocity correlation length.

  20. [Breakthrough pain treatment with sublingual fentanyl in patients with chronic cutaneous ulcers].

    Science.gov (United States)

    Domingo-Triadó, V; López Alarcón, M D; Villegas Estévez, F; Alba Moratillas, C; Massa Domínguez, B; Palomares Payá, F; Mínguez Martí, A; Debón Vicent, L

    2014-10-01

    The aim of the study was to assess the efficacy and safety of opioids in the management of pain in those patients with chronic cutaneous ulcers and breakthrough/incidental pain. An open-label, multicentre, prospective, uncontrolled study was conducted in the pain and ulcer units of 5 hospitals across the Comunidad Valenciana. Eligibility criteria were baseline pain 4 in the visual analogue scale or breakthrough procedural pain 4. Exclusion criteria were cognitive impairment, opioid intolerance, or patient refusal to provide informed consent. The protocol scheduled 5 controls: baseline (enrolment), 15 days, one month, 2 months, and 3 months. The main outcome measure of the study was the visual analogue scale score during rest, movement and procedures. Opioids were administered for release of the baseline pain, and sublingual fentanyl for breakthrough pain. A total of 32 patients (86.5%) completed the study. Baseline pain achieved a mean improvement of 3.6 visual analogue scale points (SD 2.3), movement pain improved by 3.9 points (SD 2.5) and procedural pain improved by 4.5 points (SD 2.8), and the mean pain intensity improvement was statistically significant from the first control and at all controls thereafter (PDolor. Published by Elsevier España. All rights reserved.

  1. Breakthrough analysis for water disinfection using silver nanoparticles coated resin beads in fixed-bed column

    International Nuclear Information System (INIS)

    Mthombeni, Nomcebo H.; Mpenyana-Monyatsi, Lizzy; Onyango, Maurice S.; Momba, Maggie N.B.

    2012-01-01

    Highlights: ► Performance of silver nanoparticles coated resin in water disinfection is presented. ► Sigmoidal models are used to describe breakthrough curves. ► The performance of the media in water disinfection is affected by process variables. ► Test with environmental water shows the media is effective in water disinfection. - Abstract: This study demonstrates the use of silver nanoparticles coated resin beads in deactivating microbes in drinking water in a column filtration system. The coated resin beads are characterized using X-ray diffraction (XRD), Fourier transform infra-red (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) and energy dispersive spectroscopy (EDS) to confirm the functional groups, morphology and the presence of silver nanoparticles on the surface of the resin. The performance of the coated resin is evaluated as a function of bed mass, initial bacterial concentration and flow rate using Escherichia coli as model microbial contaminant in water. The survival curves of E. coli are expressed as breakthrough curves (BTCs), which are modeled using sigmoidal regression equations to obtain relevant rate parameters. The number of bed volumes processed at breakthrough point and capacity of the bed are used as performance indicators. Results show that performance increases with a decrease in initial bacterial concentration, an increase in flow rate and an increase in bed mass.

  2. Peak and Tail Scaling of Breakthrough Curves in Hydrologic Tracer Tests

    Science.gov (United States)

    Aquino, T.; Aubeneau, A. F.; Bolster, D.

    2014-12-01

    Power law tails, a marked signature of anomalous transport, have been observed in solute breakthrough curves time and time again in a variety of hydrologic settings, including in streams. However, due to the low concentrations at which they occur they are notoriously difficult to measure with confidence. This leads us to ask if there are other associated signatures of anomalous transport that can be sought. We develop a general stochastic transport framework and derive an asymptotic relation between the tail scaling of a breakthrough curve for a conservative tracer at a fixed downstream position and the scaling of the peak concentration of breakthrough curves as a function of downstream position, demonstrating that they provide equivalent information. We then quantify the relevant spatiotemporal scales for the emergence of this asymptotic regime, where the relationship holds, in the context of a very simple model that represents transport in an idealized river. We validate our results using random walk simulations. The potential experimental benefits and limitations of these findings are discussed.

  3. Breakthrough revisited: investigating the requirements for growth of dust beyond the bouncing barrier

    Science.gov (United States)

    Booth, Richard A.; Meru, Farzana; Lee, Man Hoi; Clarke, Cathie J.

    2018-03-01

    For grain growth to proceed effectively and lead to planet formation, a number of barriers to growth must be overcome. One such barrier, relevant for compact grains in the inner regions of the disc, is the `bouncing barrier' in which large grains (˜mm size) tend to bounce off each other rather than sticking. However, by maintaining a population of small grains, it has been suggested that cm-size particles may grow rapidly by sweeping up these small grains. We present the first numerically resolved investigation into the conditions under which grains may be lucky enough to grow beyond the bouncing barrier by a series of rare collisions leading to growth (so-called `breakthrough'). Our models support previous results, and show that in simple models breakthrough requires the mass ratio at which high-velocity collisions transition to growth instead of causing fragmentation to be low, ϕ ≲ 50. However, in models that take into account the dependence of the fragmentation threshold on mass ratio, we find that breakthrough occurs more readily, even if mass transfer is relatively inefficient. This suggests that bouncing may only slow down growth, rather than preventing growth beyond a threshold barrier. However, even when growth beyond the bouncing barrier is possible, radial drift will usually prevent growth to arbitrarily large sizes.

  4. Model for the Value of a Business, Some Optimisation Problems in its Operating Procedures and the Valuation of its Debt

    OpenAIRE

    M.Z. Apabhai; N.I. Georgikopoulos; D. Hasnip; R.K.D. Jamie; M. Kim

    1999-01-01

    In this paper we present a model for the value of a firm based on observable variables and parameters: the annual turnover, the expenses, interest rates. This value is the solution of a parabolic partial differential equation. We show how the value of the company depends on its legal status such as its liability (i.e. whether it is a Limited Company or a sole trader/partnership). We give examples of how the operating procedures can be optimised (e.g. whether the firm should close down, reloca...

  5. Schema building profiles among elementary school students in solving problems related to operations of addition to fractions on the basis of mathematic abilities

    Science.gov (United States)

    Gembong, S.; Suwarsono, S. T.; Prabowo

    2018-03-01

    Schema in the current study refers to a set of action, process, object and other schemas already possessed to build an individual’s ways of thinking to solve a given problem. The current study aims to investigate the schemas built among elementary school students in solving problems related to operations of addition to fractions. The analyses of the schema building were done qualitatively on the basis of the analytical framework of the APOS theory (Action, Process, Object, and Schema). Findings show that the schemas built on students of high and middle ability indicate the following. In the action stage, students were able to add two fractions by way of drawing a picture or procedural way. In the Stage of process, they could add two and three fractions. In the stage of object, they could explain the steps of adding two fractions and change a fraction into addition of fractions. In the last stage, schema, they could add fractions by relating them to another schema they have possessed i.e. the least common multiple. Those of high and middle mathematic abilities showed that their schema building in solving problems related to operations odd addition to fractions worked in line with the framework of the APOS theory. Those of low mathematic ability, however, showed that their schema on each stage did not work properly.

  6. Prospect and problems of self-supporting nuclear fuel cycle operation in Korea beyond the year 2000

    International Nuclear Information System (INIS)

    Kim, Chang Hyo

    1988-01-01

    Korea ranks tenth in the free world in the installed capacity of nuclear power plants. Since she lacks in indigenous uranium resources and built-in domestic fuel cycle technology, however, she had to rely heavily upon overseas uranium markets and fuel cycle services. Despite the fact that localization of fuel fabrication technology is nearly achieved, such issues as the timely and stable procurement of front-end fuel cycle services including uranium ore, interim storage and ultimate fuel cycle services including uranium ore, interim storage and ultimate disposal of ever-accumulating spent fuels, disposal of radioactive waste, and decommissioning of the retiring nuclear power plants has yet fuel cycle technology beyond the year 2000. The purpose of this report is to identify these issues of fuel cycle operation and to suggest mobilizing nation's research potential for establishing self-reliant fuel cycle technology beyond the year 2000

  7. Recommendations regarding problems of research policy relating to the establishment and operation of atomic power stations in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    1976-01-01

    This report, which was submitted by the Danish Planning Council for Research to the Parliamentary Committee on Scientific Research, is based on reports from the DANISH Atomic Energy Commission. and on a sub-committee appointed by the Planning Council, as well as on the comments of the Danish Research Council on these reports. The Planning Council submit that: (1) the question of the introduction and scope of Danish utilization of atomic energy should be considered as a link in setting up a total plan for energy policy elucidating the possibilities in the energy field from both aspects of supply and demand, (2) that there is a continuous interaction between energy policy and research policy in the subject field, (3) that the total resources for energy research and development should be considerably increased, (4) that investigations into the economy of atomic power should be intensified, and (5) that investigations of possibilities for long-term storage of radioactive waste in Denmark should be speeded up. Further, the Planning Council points out the need for research in areas such as (a) wind and solar energy, (b) the environmental impact of utilizing atomic power in relation to that of utilizing other forms of power, (c) economic and social effects of different forms of energy supply, as well as the problems of siting, decision taking and public information and participation and finally, (d) the utilization of the energy raw materials found in Greenland.

  8. Recommendations regarding problems of research policy relating to the establishment and operation of atomic power stations in Denmark

    International Nuclear Information System (INIS)

    1976-01-01

    This report, which was submitted by the Danish Planning Council for Research to the Parliamentary Committee on Scientific Research, is based on reports from the DANISH Atomic Energy Commission. and on a sub-committee appointed by the Planning Council, as well as on the comments of the Danish Research Council on these reports. The Planning Council submit that: 1) the question of the introduction and scope of Danish utilization of atomic energy should be considered as a link in setting up a total plan for energy policy elucidating the possibilities in the energy field from both aspects of supply and demand, 2) that there is a continuous interaction between energy policy and research policy in the subject field 3) that the total resources for energy research and development should be considerably increased, 4) that investigations into the economy of atomic power should be intensified, and 5) that investigations of possibilities for long-term storage of radioactive waste in Denmark should be speeded up. Further, the Planning Council points out the need for research in areas such as a) wind and solar energy, b) the environmental impact of utilizing atomic power in relation to that of utilizing other forms of power, c) economic and social effects of different forms of energy supply, as well as the problems of siting, decision taking and public information and participation and finally, d) the utilization of the energy raw materials found in Greenland. (B.P.)

  9. An Analysis of the Network Selection Problem for Heterogeneous Environments with User-Operator Joint Satisfaction and Multi-RAT Transmission

    Directory of Open Access Journals (Sweden)

    J. J. Escudero-Garzás

    2017-01-01

    Full Text Available The trend in wireless networks is that several wireless radio access technologies (RATs coexist in the same area, forming heterogeneous networks in which the users may connect to any of the available RATs. The problem of associating a user to the most suitable RAT, known as network selection problem (NSP, is of capital importance for the satisfaction of the users in these emerging environments. However, also the satisfaction of the operator is important in this scenario. In this work, we propose that a connection may be served by more than one RAT by using multi-RAT terminals. We formulate the NSP with multiple RAT association based on utility functions that take into consideration both user’s satisfaction and provider’s satisfaction. As users are characterized according to their expected quality of service, our results exhaustively analyze the influence of the user’s profile, along with the network topology and the type of applications served.

  10. Analysis of the structure and operation of the level F PL/1 compiler: problems raised by the coupling of programmes written in different languages

    International Nuclear Information System (INIS)

    Rambou Sek, Jiri

    1974-01-01

    As the PL/1 programming language allows the treatment of a large range of commercial and scientific problems, it also raises specific problems for the development of a compiler on the one hand, and for the implementation of a management system within an installation comprising software written in different programming languages. The author reports the analysis of the level F PL/1 compiler developed by IBM, discusses issues related to the management of a PL/1 software within the framework of the OS/360 operating system. He reports the study of the linking conditions between PL/1 and the main existing programming languages under OS/360. He presents an interface system which allows a common exploitation of software written in different programming languages. He describes the syntax of the DECLARE statement, and its analysis by the interface system. The last part reports the generation of different data description vectors which are necessary for argument transmission [fr

  11. ACTIVE MARKETING STRATEGY IN THE EDUCATION MARKET:BREAKTHROUGH POSITIONING STRATEGY IN PROMOTING UNIVERSITY’S INNOVATIONS

    OpenAIRE

    Pashkus N.A; Pashkus V.

    2013-01-01

    The article discusses the possibility of using active marketing strategies for promoting the results of university’s innovations. Benefits, that can be obtained by university through its strategy of breakthrough positioning explored

  12. OPERATOR-RELATED FORMULATION OF THE EIGENVALUE PROBLEM FOR THE BOUNDARY PROBLEM OF ANALYSIS OF A THREE-DIMENSIONAL STRUCTURE WITH PIECEWISE-CONSTANT PHYSICAL AND GEOMETRICAL PARAMETERS ALONGSIDE THE BASIC DIRECTION WITHIN THE FRAMEWORK OF THE DISCRETE-CON

    Directory of Open Access Journals (Sweden)

    Akimov Pavel Alekseevich

    2012-10-01

    Full Text Available The proposed paper covers the operator-related formulation of the eigenvalue problem of analysis of a three-dimensional structure that has piecewise-constant physical and geometrical parameters alongside the so-called basic direction within the framework of a discrete-continual approach (a discrete-continual finite element method, a discrete-continual variation method. Generally, discrete-continual formulations represent contemporary mathematical models that become available for computer implementation. They make it possible for a researcher to consider the boundary effects whenever particular components of the solution represent rapidly varying functions. Another feature of discrete-continual methods is the absence of any limitations imposed on lengths of structures. The three-dimensional problem of elasticity is used as the design model of a structure. In accordance with the so-called method of extended domain, the domain in question is embordered by an extended one of an arbitrary shape. At the stage of numerical implementation, relative key features of discrete-continual methods include convenient mathematical formulas, effective computational patterns and algorithms, simple data processing, etc. The authors present their formulation of the problem in question for an isotropic medium with allowance for supports restrained by elastic elements while standard boundary conditions are also taken into consideration.

  13. The Daily Operational Brief: Fostering Daily Readiness, Care Coordination, and Problem-Solving Accountability in a Large Pediatric Health Care System.

    Science.gov (United States)

    Donnelly, Lane F; Basta, Kathryne C; Dykes, Anne M; Zhang, Wei; Shook, Joan E

    2018-01-01

    At a pediatric health system, the Daily Operational Brief (DOB) was updated in 2015 after three years of operation. Quality and safety metrics, the patient volume and staffing assessment, and the readiness assessment are all presented. In addition, in the problem-solving accountability system, problematic issues are categorized as Quick Hits or Complex Issues. Walk-the-Wall, a biweekly meeting attended by hospital senior administrative leadership and quality and safety leaders, is conducted to chart current progress on Complex Issues. The DOB provides a daily standardized approach to evaluate readiness to provide care to current patients and improvement in the care to be provided for future patients. Copyright © 2017 The Joint Commission. Published by Elsevier Inc. All rights reserved.

  14. Rapid breakthrough of pesticides via biopres into tile drains and shallow groundwater: a combined experimental and model study

    Science.gov (United States)

    Klaus, J.; Zehe, E.; Palm, J.; Schroeder, B.

    2009-04-01

    Preferential flow in macropores is a key process which strongly affects infiltration and may cause rapid transport of pesticides into depths of 80 to 150 cm. At these depths they experience a much slower degradation, may leach into shallow groundwater or enter a tile-drain and are transported in surface water bodies. Therefore, preferential transport is an environ¬mental problem because the topsoil is bypassed, which has been originally thought to act as a filter to protect the subsoil and shallow groundwater. To get a better insight in the process of pesticide transport in agricultural soils an irrigation experiment was performed on a 400 m² field site. The experimental plot is located in the Weiherbach valley, south-west Germany, which basic geology consists of Loess and Keuper layers, the soil at the test site is a gleyic Colluvisol. The distance of the irrigation site to the Weiherbach brook is aprox. 12 m, the field is drained with a tile-drain in about 1.2 m depth and the shows runoff over the entire year. Three hours before the irrigation started the farmer applied a pesticide solution consisting of Isoproturon and Flufenacet according to conventional agricultural practice. The irrigation took place in three time blocks (80 min, 60 min, 80 min) and had a total irrigation rate of 33.6 mm measured with ten precipitation samplers. During the first block a tracer solution of 1600 g Bromide and 2000 g Brilliant Blue was irrigated on the test site. The drainage outlet was instrumented with a pressure probe to measure the water level. About 50 water samples were taken on the day of the experiment from the drainage outlet by hand, and in an eight hour interval for six days with an automatic sample procedure. Discharge at the drainage outlet showed two peaks in response irrigation. The breakthrough of the tracer into the brook is much faster then the reaction of the discharge on the precipitation impulse. To gain insight in the vertical transport behaviour three

  15. Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment

    DEFF Research Database (Denmark)

    Arendrup, Maiken Cavling; Garcia-Effron, Guillermo; Buzina, Walter

    2009-01-01

    Caspofungin is used for the treatment of acute invasive candidiasis and as salvage treatment for invasive aspergillosis. We report characteristics of isolates of Candida albicans and Aspergillus fumigatus detected in a patient with breakthrough infection complicating severe gastrointestinal surgery...... without FSK1 resistance mutations in liver and lung tissues. Breakthrough disseminated aspergillosis and candidiasis developed despite an absence of characteristic FKS1 resistance mutations in the Aspergillus isolates. EUCAST and CLSI methodology did not separate the candin-resistant clinical isolate from...

  16. The IDA cognitive model for the analysis of nuclear power plant operator response under accident conditions. Part I: problem solving and decision making model

    International Nuclear Information System (INIS)

    Smidts, C.; Shen, S.H.; Mosleh, A.

    1997-01-01

    This paper is the first of a series of papers describing IDA which is a cognitive model for analysing the behaviour of nuclear power plant operators under accident conditions. The domain of applicability of the model is a relatively constrained environment where behaviour is significantly influenced by high levels of training and explicit requirement to follow written procedures. IDA consists of a model for individual operator behaviour and a model for control room operating crew expanded from the individual model. The model and its derivatives such as an error taxonomy and data collection approach has been designed with ultimate objective of becoming a quantitative method for human reliability analysis (HRA) in probabilistic risk assessment (PRA). The present paper gives a description of the main components of IDA such as memory structure, goals, and problem solving and decision making strategies. It also identifies factors that are at the origin of transitions between goals or between strategies. These factors cover the effects of external conditions and psychological state of the operator. The description is generic at first and then made specific to the nuclear power plant environment and more precisely to abnormal conditions

  17. Making synthetic mudstone: Parametric resedimentation studies at high effective stress to determine controls on breakthrough pressure and permeability

    Science.gov (United States)

    Guiltinan, E. J.; Cardenas, M. B.; Cockrell, L.; Espinoza, N.

    2017-12-01

    The geologic sequestration of CO2 is widely considered a potential solution for decreasing anthropogenic atmospheric CO2 emissions. As CO2 rises buoyantly within a reservoir it pools beneath a caprock and a pressure is exerted upon the pores of the caprock proportionally to the height of the pool. The breakthrough pressure is the point at which CO2 begins to flow freely across the caprock. Understanding the mineralogical and grain size controls on breakthrough pressure is important for screening the security of CO2 sequestration sites. However, breakthrough pressure and permeability measurements on caprocks are difficult to conduct in a systematic manner given the variability in and heterogeneity of naturally occurring mudstones and shales causing significant noise and scatter in the literature. Recent work has even revealed the ability for CO2 to pass through thin shale beds at relatively low pressures. To broaden the understanding of shale breakthrough and permeability, we developed an approach that allows for the creation of resedimented mudstones at high effective stresses. Resedimented samples also include calcium carbonate cement. Using this technique, we explore the controls on entry pressure, breakthrough pressure, and permeability of synthetic mudstones. Understanding the effect of mineralogy and grain size on the permeability and breakthrough pressure of mudstones at reservoir stresses will help in the selection and uncertainty quantification of secure CO2 storage sites.

  18. Random walk-percolation-based modeling of two-phase flow in porous media: Breakthrough time and net to gross ratio estimation

    Science.gov (United States)

    Ganjeh-Ghazvini, Mostafa; Masihi, Mohsen; Ghaedi, Mojtaba

    2014-07-01

    Fluid flow modeling in porous media has many applications in waste treatment, hydrology and petroleum engineering. In any geological model, flow behavior is controlled by multiple properties. These properties must be known in advance of common flow simulations. When uncertainties are present, deterministic modeling often produces poor results. Percolation and Random Walk (RW) methods have recently been used in flow modeling. Their stochastic basis is useful in dealing with uncertainty problems. They are also useful in finding the relationship between porous media descriptions and flow behavior. This paper employs a simple methodology based on random walk and percolation techniques. The method is applied to a well-defined model reservoir in which the breakthrough time distributions are estimated. The results of this method and the conventional simulation are then compared. The effect of the net to gross ratio on the breakthrough time distribution is studied in terms of Shannon entropy. Use of the entropy plot allows one to assign the appropriate net to gross ratio to any porous medium.

  19. Procedure and accuracy in the Eurotunnel breakthrough. Vorgehensweise und Genauigkeit beim Durchschlag des Eurotunnels

    Energy Technology Data Exchange (ETDEWEB)

    Korittke, N. (DMT-Gesellschaft fuer Forschung und Pruefung mbH, Essen (Germany, F.R.). Inst. fuer Lagerstaette und Vermessung (ILV))

    1991-02-14

    After a construction time of about 2.5 years the first link was made in the Eurotunnel between France and England, viz. the service tunnel, on 1 December 1990. Thanks to the accurate Gyromat measurements of the Institute for Mineral Deposits and Surveying of the Deutsche Montan Technologie (DMT) a transverse deviation of only 361 mm, a longitudinal deviation of 69 mm and a vertical deviation of 58 mm were determined in the breakthrough of the 22.3 and 15.6 km long tunnel sections. (orig.).

  20. Epicardial Breakthrough Waves During Sinus Rhythm: Depiction of the Arrhythmogenic Substrate?

    Science.gov (United States)

    Mouws, Elisabeth M J P; Lanters, Eva A H; Teuwen, Christophe P; van der Does, Lisette J M E; Kik, Charles; Knops, Paul; Bekkers, Jos A; Bogers, Ad J J C; de Groot, Natasja M S

    2017-09-01

    Epicardial breakthrough waves (EBW) during atrial fibrillation are important elements of the arrhythmogenic substrate and result from endo-epicardial asynchrony, which also occurs to some degree during sinus rhythm (SR). We examined the incidence and characteristics of EBW during SR and its possible value in the detection of the arrhythmogenic substrate associated with atrial fibrillation. Intraoperative epicardial mapping (interelectrode distances 2 mm) of the right atrium, Bachmann's bundle, the left atrioventricular groove, and the pulmonary vein area was performed during SR in 381 patients (289 male, 67±10 years) with ischemic or valvular heart disease. EBW were referred to as sinus node breakthrough waves if they were the earliest right atrial activated site. A total of 218 EBW and 57 sinus node breakthrough waves were observed in 168 patients (44%). EBW mostly occurred at right atrium (N=105, 48%) and left atrioventricular groove (N=67, 31%), followed by Bachmann's bundle (N=27, 12%) and pulmonary vein area (N=19, 9%; P <0.001). EBW occurred most often in ischemic heart disease patients (N=114, 49%) compared with (ischemic and) valvular heart disease patients (N=26, 17%; P <0.001). EBW electrograms most often consisted of double and fractionated potentials (N=137, 63%). In case of single potentials, an R wave was observed in 88% (N=71) of EBW, as opposed to 21% of sinus node breakthrough waves (N=5; P <0.001). Fractionated EBW potentials were more often observed at the right atrium and Bachmann's bundle ( P <0.001). During SR, EBW are present in over a third of patients, particularly in thicker parts of the atrial wall. Features of SR EBW indicate that muscular connections between endo- and epicardium underlie EBW and that a slight degree of endo-epicardial asynchrony required for EBW to occur is already present in some areas during SR. Hence, an anatomic substrate is present, which may enhance the occurrence of EBW during atrial fibrillation, thereby

  1. Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial.

    Directory of Open Access Journals (Sweden)

    Paul T Edlefsen

    2015-02-01

    Full Text Available The RV144 clinical trial showed the partial efficacy of a vaccine regimen with an estimated vaccine efficacy (VE of 31% for protecting low-risk Thai volunteers against acquisition of HIV-1. The impact of vaccine-induced immune responses can be investigated through sieve analysis of HIV-1 breakthrough infections (infected vaccine and placebo recipients. A V1/V2-targeted comparison of the genomes of HIV-1 breakthrough viruses identified two V2 amino acid sites that differed between the vaccine and placebo groups. Here we extended the V1/V2 analysis to the entire HIV-1 genome using an array of methods based on individual sites, k-mers and genes/proteins. We identified 56 amino acid sites or "signatures" and 119 k-mers that differed between the vaccine and placebo groups. Of those, 19 sites and 38 k-mers were located in the regions comprising the RV144 vaccine (Env-gp120, Gag, and Pro. The nine signature sites in Env-gp120 were significantly enriched for known antibody-associated sites (p = 0.0021. In particular, site 317 in the third variable loop (V3 overlapped with a hotspot of antibody recognition, and sites 369 and 424 were linked to CD4 binding site neutralization. The identified signature sites significantly covaried with other sites across the genome (mean = 32.1 more than did non-signature sites (mean = 0.9 (p < 0.0001, suggesting functional and/or structural relevance of the signature sites. Since signature sites were not preferentially restricted to the vaccine immunogens and because most of the associations were insignificant following correction for multiple testing, we predict that few of the genetic differences are strongly linked to the RV144 vaccine-induced immune pressure. In addition to presenting results of the first complete-genome analysis of the breakthrough infections in the RV144 trial, this work describes a set of statistical methods and tools applicable to analysis of breakthrough infection genomes in general vaccine

  2. So That's How! 2007 Microsoft® Office System Timesavers, Breakthroughs, & Everyday Genius

    CERN Document Server

    Archilla, Evan

    2009-01-01

    Turn your productivity drains into productivity gains! With this practical (and fun) guide, you'll discover the best ways to tackle your daily work with the 2007 Microsoft Office system. The authors have taught thousands of people to get better results with less effort. Now these efficiency experts let you steal from their "tip jar" full of timesaving shortcuts and other brilliant ideas. You'll explore what's new in your favorite Microsoft Office programs-and transform the way you work. Get timesavers, breakthroughs, & everyday genius to: Take control of your inbox, calendar, and everyday in

  3. The Impact of Breakthrough Therapy Designation on Development Strategies and Timelines for Nononcology Drugs and Vaccines.

    Science.gov (United States)

    Poirier, A F; Murphy, W R

    2016-12-01

    The US Food and Drug Administration (FDA) Safety and Innovation Act (FDASIA, 2012) introduced the Breakthrough Therapy Designation (BTD), a new tool to expedite development of medicines to treat serious or life-threatening diseases. The majority of BTDs have gone to oncology drugs, and a recent publication by Shea et al. 1 reviewed the impact of BTD on oncology drug development. This article reviews the impact of BTD on development strategies and timelines for nononcology drugs. © 2016 American Society for Clinical Pharmacology and Therapeutics.

  4. Effect of Relative Humidity on Adsorption Breakthrough of CO2 on Activated Carbon Fibers

    Directory of Open Access Journals (Sweden)

    Yu-Chun Chiang

    2017-11-01

    Full Text Available Microporous activated carbon fibers (ACFs were developed for CO2 capture based on potassium hydroxide (KOH activation and tetraethylenepentamine (TEPA amination. The material properties of the modified ACFs were characterized using several techniques. The adsorption breakthrough curves of CO2 were measured and the effect of relative humidity in the carrier gas was determined. The KOH activation at high temperature generated additional pore networks and the intercalation of metallic K into the carbon matrix, leading to the production of mesopore and micropore volumes and providing access to the active sites in the micropores. However, this treatment also resulted in the loss of nitrogen functionalities. The TEPA amination has successfully introduced nitrogen functionalities onto the fiber surface, but its long-chain structure blocked parts of the micropores and, thus, made the available surface area and pore volume limited. Introduction of the power of time into the Wheeler equation was required to fit the data well. The relative humidity within the studied range had almost no effects on the breakthrough curves. It was expected that the concentration of CO2 was high enough so that the impact on CO2 adsorption capacity lessened due to increased relative humidity.

  5. Hand Hygiene Improvement and Sustainability: Assessing a Breakthrough Collaborative in Western Switzerland.

    Science.gov (United States)

    Staines, Anthony; Amherdt, Isabelle; Lécureux, Estelle; Petignat, Christiane; Eggimann, Philippe; Schwab, Marcos; Pittet, Didier

    2017-12-01

    OBJECTIVE To assess hand hygiene improvement and sustainability associated with a Breakthrough Collaborative. DESIGN Multicenter analysis of hand hygiene compliance through direct observation by trained observers. SETTING A total of 5 publicly funded hospitals in 14 locations, with a total of 1,152 beds, in the County of Vaud, Switzerland. PARTICIPANTS Clinical staff. INTERVENTIONS In total, 59,272 opportunities for hand hygiene were monitored for the duration of the study, for an average of 5,921 per audit (range, 5,449-6,852). An 18-month Hand Hygiene Breakthrough Collaborative was conducted to implement the WHO multimodal promotional strategy including improved access to alcohol-based hand rub, education, performance measurement and feedback, reminders and communication, leadership engagement, and safety culture. RESULTS Overall hand hygiene compliance improved from 61.9% to 88.3% (Pstrategy for content and measurement was associated with significant and substantial improvement in compliance across all professions, all hand hygiene indications, and all participating hospitals. Infect Control Hosp Epidemiol 2017;38:1420-1427.

  6. Proposal to realize a cost breakthrough in carbon-13 production by photochemical separation

    International Nuclear Information System (INIS)

    Marling, J.B.

    1979-10-01

    A cost breakthrough can now be made in photochemical production of the rare stable isotope carbon-13. This cost breakthrough is achieved by CO 2 laser infrared multiple-photon dissociation of any of several halocarbons (Freon derivatives) such as CF 3 Cl, CF 3 Br, or CF 2 Cl 2 . The single-step carbon-13 enrichment factor for this process is approximately 50, yielding 30% pure C-13 in one step, or up to 97% pure C-13 in two steps. A three-fold carbon-13 cost reduction to below $20/gram is expected to be achieved in a small laboratory-scale demonstration facility capable of producing 4 to 8 kg/year of carbon-13, using presently available pulsed CO 2 TEA lasers at an average power level of 50 watts. Personnel costs dominate the attainable C-13 production costs in a small photochemical enrichment facility. A price reduction to $2/gm carbon-13 is feasible at carbon-13 production levels of 100 to 1000 kg/year, dominated by the Freon raw material costs

  7. Acceptability of the Distress Thermometer and Problem List to community-based telephone cancer helpline operators, and to cancer patients and carers

    Directory of Open Access Journals (Sweden)

    Sargeant Hilary

    2011-01-01

    Full Text Available Abstract Background Cancer can be a distressing experience for cancer patients and carers, impacting on psychological, social, physical and spiritual functioning. However, health professionals often fail to detect distress in their patients due to time constraints and a lack of experience. Also, with the focus on the patient, carer needs are often overlooked. This study investigated the acceptability of brief distress screening with the Distress Thermometer (DT and Problem List (PL to operators of a community-based telephone helpline, as well as to cancer patients and carers calling the service. Methods Operators (n = 18 monitored usage of the DT and PL with callers (cancer patients/carers, >18 years, and English-speaking from September-December 2006 (n = 666. The DT is a single item, 11-point scale to rate level of distress. The associated PL identifies the cause of distress. Results The DT and PL were used on 90% of eligible callers, most providing valid responses. Benefits included having an objective, structured and consistent means for distress screening and triage to supportive care services. Reported challenges included apparent inappropriateness of the tools due to the nature of the call or level of caller distress, the DT numeric scale, and the level of operator training. Conclusions We observed positive outcomes to using the DT and PL, although operators reported some challenges. Overcoming these challenges may improve distress screening particularly by less experienced clinicians, and further development of the PL items and DT scale may assist with administration. The DT and PL allow clinicians to direct/prioritise interventions or referrals, although ongoing training and support is critical in distress screening.

  8. Development, validation and psychometric properties of a diagnostic/prognostic tool for breakthrough pain in mixed chronic-pain patients.

    Science.gov (United States)

    Samolsky Dekel, Boaz Gedaliahu; Remondini, Francesca; Gori, Alberto; Vasarri, Alessio; Di Nino, GianFranco; Melotti, Rita Maria

    2016-02-01

    Breakthrough pain (BTP) shows variable prevalence in different clinical contexts of cancer and non-cancer patients. BTP diagnostic tools with demonstrated reliability, validation and prognostic capability are lacking. We report the development, psychometric and validation properties of a diagnostic/prognostic tool, the IQ-BTP, for BTP recognition, its likelihood and clinical features among chronic-pain (CP) patients. n=120 consecutive mixed cancer/non-cancer CP in/outpatients. Development, psychometric analyses and formal validation included: Face/Content validity (by 'experts' opinion and assessing the relationship between the IQ-BTP classes and criteria derived from BTP operational-case-definition); Construct validity, by Principle Component Analysis (PCA); and the strength of Spearman correlation between IQ-BTP classes and the Brief Pain Inventory (BPI) items; Reliability, by Cronbach's alpha statistics. Associations with clinical/demographic moderators were assessed applying χ(2) analysis. Potential-BTP was found in 36.7% of patients (38.4% of non-cancer and 32.4% of cancer patients). Among these the likelihood for BTP diagnosis was 'high' in 25%, 'intermediate' in 41% and, 'low' 34% of patients. Analyses showed significant differences between IQ-BTP classes and between the latter BPI pain-item scores. Correlation between IQ-BTP classes and BPI items was moderate. PCA and scree test identified 3 components accounting for 62.3% of the variance. Cronbach's alpha was 0.71. The IQ-BTP showed satisfactory psychometric and validation properties. With adequate feasibility it enabled the allocating of cancer/non-cancer CP patients in three prognostic classes. Results are sufficient to warrant a subsequent impact study of the IQ-BTP as prognostic model and screening tool for BTP in both CP populations. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Breakthrough curve of H/sub 2/-Ti-sponge adsorption system

    Energy Technology Data Exchange (ETDEWEB)

    Yasufuku, K [Kawasaki Heavy Industries Ltd., Kobe (Japan)

    1977-11-01

    Experimental work concerning H/sub 2/-Ti-sponge adsorption system has been undertaken at Kawasaki Heavy Industry Co. to obtain necessary data for the design of hydrogen removal tower (Ti-sponge trap) to be used as an purification component of a VHTR plant. In this study, the effects of equilibrium curve, H/sub 2/ inlet concentration, and the ratio of the solid-side capacity factor to the gas-side capacity factor on the breakthrough curve were investigated. The Freundlich's equation with the diffusion model of Carter et al. was numerically solved by the Crank-Nicholson method, and the results of calculations are presented. The flow diagram and the photographs of the facilities for He gas purification experiments are also presented.

  10. Central Hyperexcitability in Chronic Musculoskeletal Pain: A Conceptual Breakthrough with Multiple Clinical Implications

    Directory of Open Access Journals (Sweden)

    Jan Lidbeck

    2002-01-01

    Full Text Available Recent investigations of dysfunctional pain processing in the central nervous system have contributed much knowledge about the development of chronic musculoskeletal pain. Many common chronic musculoskeletal pain syndromes - including regional myofascial pain syndromes, whiplash pain syndromes, refractory work-related neck-shoulder pain, certain types of chronic low back pain, fibromyalgia and others - may essentially be explained by abnormalities in central pain modulation. The growing awareness of dysfunctional central pain modulation may be a conceptual breakthrough leading to a better understanding of common chronic pain disorders. A new paradigm will have multiple clinical implications, including re-evaluation of clinical practice routines and rehabilitation methods, and will focus on controversial issues of medicolegal concern. The concept of dysfunctional central pain processing will also necessitate a mechanism-based classification of pain for the selection of individual treatment and rehabilitation programs for subgroups of patients with chronic musculoskeletal pain due to different pathophysiological mechanisms.

  11. Fentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl.

    Science.gov (United States)

    Alberts, David S; Smith, Christina Cognata; Parikh, Neha; Rauck, Richard L

    2016-10-01

    To investigate the relationship between effective fentanyl sublingual spray (FSS) doses for breakthrough cancer pain (BTCP) and around-the-clock (ATC) transdermal fentanyl patch (TFP). Adults tolerating ATC opioids received open-label FSS for 26 days, followed by a 26-day double-blind phase for patients achieving an effective dose (100-1600 µg). Out of 50 patients on ATC TFP at baseline, 32 (64%) achieved an effective dose. FSS effective dose moderately correlated with mean TFP dose (r = 0.4; p = 0.03). Patient satisfaction increased during the study. Common adverse event included nausea (9%) and peripheral edema (9%). FSS can be safely titrated to an effective dose for BTCP in patients receiving ATC TFP as chronic cancer pain medication. ClinicalTrials.gov identifier: NCT00538850.

  12. Ovarian stem cells and neo-oogenesis: A breakthrough in reproductive biology research

    Directory of Open Access Journals (Sweden)

    S Mooyottu1

    2011-04-01

    Full Text Available The concept of ovarian stem cells which can replenish the ovarian reserve in postnatal mammalian females is a revolutionary breakthrough in reproductive biology. This idea overturned the central dogma existed in female reproductive physiology. Contradicting the popular belief that oogenesis does not occur in post natal life, researchers proved the existence of putative stem cells in ovary, which can supply functional follicles in post natal ovaries. Even though the idea of neo-oogenesis in postnatal ovaries in normal conditions is controversial, the isolation and manipulation of ovarian stem cells have got tremendous application in medical, veterinary and animal production fields. [Veterinary World 2011; 4(2.000: 89-91

  13. From Bottleneck to Breakthrough: Urbanization and the Future of Biodiversity Conservation.

    Science.gov (United States)

    Sanderson, Eric W; Walston, Joseph; Robinson, John G

    2018-06-01

    For the first time in the Anthropocene, the global demographic and economic trends that have resulted in unprecedented destruction of the environment are now creating the necessary conditions for a possible renaissance of nature. Drawing reasonable inferences from current patterns, we can predict that 100 years from now, the Earth could be inhabited by between 6 and 8 billion people, with very few remaining in extreme poverty, most living in towns and cities, and nearly all participating in a technologically driven, interconnected market economy. Building on the scholarship of others in demography, economics, sociology, and conservation biology, here, we articulate a theory of social-environmental change that describes the simultaneous and interacting effects of urban lifestyles on fertility, poverty alleviation, and ideation. By recognizing the shifting dynamics of these macrodrivers, conservation practice has the potential to transform itself from a discipline managing declines ("bottleneck") to a transformative movement of recovery ("breakthrough").

  14. Solar Spicules: Prospects for Breakthroughs in Understanding with Solar-B

    Science.gov (United States)

    Sterling, A.

    Spicules densely populate the lower solar atmosphere; any image or movie of the chromosphere shows a plethora of them or their "cousins," such as mottles or fibrils. Yet despite several decades of effort we still do not know the mechanism that generates them, or how important their contribution is to the material and energy balance of the overall solar atmosphere. Solar-B will provide exciting new chromospheric observations at high time- and spatial-resolution, along with associated quality magnetic field data, that promise to open doors to revolutionary breakthroughs in spicule research. In this presentation we will review the current observational and theoretical status of spicule studies, and discuss prospects for advances in spicule understanding during the Solar-B era.

  15. Plastic fracture instability analysis of wall breakthrough in a circumferentially cracked pipe subjected to bending loads

    International Nuclear Information System (INIS)

    Zahoor, A.; Kanninen, M.F.

    1981-01-01

    A method of analyzing internal surface circumferential cracks in ductile reactor piping is presented. The method utilizes an alternate but equivalent definition of the J-integral based on nonlinear structural compliance. The analysis is valid for situations where the cross section containing the crack is fully yielded. Results are obtained for radial and circumferential crack growth for pipes subjected to bending. The stability of radial crack growth (wall breakthrough) is assessed using the J-integral-based tearing modulus approach. The analysis is shown to be in agreement with experimental results on the stability of surface crack growth in Type 304 stainless stee pipes. Example quantitative results for fracture instability assessments for nuclear piping are presented. 23 refs

  16. Plastic fracture instability analysis of wall breakthrough in a circumferentially cracked pipe subjected to bending loads

    Energy Technology Data Exchange (ETDEWEB)

    Zahoor, A.; Kanninen, M.F.

    1981-07-01

    A method of analyzing internal surface circumferential cracks in ductile reactor piping is presented. The method utilizes an alternate but equivalent definition of the J-integral based on nonlinear structural compliance. The analysis is valid for situations where the cross section containing the crack is fully yielded. Results are obtained for radial and circumferential crack growth for pipes subjected to bending. The stability of radial crack growth (wall breakthrough) is assessed using the J-integral-based tearing modulus approach. The analysis is shown to be in agreement with experimental results on the stability of surface crack growth in Type 304 stainless stee pipes. Example quantitative results for fracture instability assessments for nuclear piping are presented. 23 refs.

  17. Posterior reversible encephalopathy syndrome and acute post-streptococcal glomerulonephritis mimicking breakthrough seizures

    Directory of Open Access Journals (Sweden)

    Kamille Abdool

    2015-05-01

    Full Text Available We report the case of a 14-year-old boy with a past history of primary generalized seizures, who had been seizure-free for 2 years on sodium valproate and presented with generalized tonic clonic seizures suggestive of breakthrough seizures. Examination revealed hypertension, impetiginous lesions of the lower limbs, microscopic hematuria, elevated antistreptolysin O titre and low complement levels consistent with acute post-streptococcal glomerulonephritis. Cranial magnetic resonance imaging (MRI demonstrated changes consistent with posterior reversible encephalopathy syndrome. Hypertension was controlled with intravenous nitroglycerin followed by oral captopril and amlodipine. Brain MRI changes returned normal within 2 weeks. The nephritis went in to remission within 2 months and after 8 months the patient has been seizure free again. Posterior reversible encephalopathy syndrome appeared to have neither short nor intermediate effect on seizure control in this patient. The relationship between posterior reversible encephalopathy syndrome and seizures is reviewed.

  18. On the late-time behavior of tracer test breakthrough curves

    Energy Technology Data Exchange (ETDEWEB)

    HAGGERTY, ROY; MCKENNA, SEAN A; MEIGS, LUCY C

    2000-06-12

    The authors investigated the late-time (asymptotic) behavior of tracer test breakthrough curves (BTCs) with rate-limited mass transfer (e.g., in dual or multi-porosity systems) and found that the late-time concentration, c, is given by the simple expression: c = t{sub ad} (c{sub 0}g {minus} m{sub 0}{partial_derivative}g/{partial_derivative}t), for t >> t{sub ad} and t{sub a} >> t{sub ad} where t{sub ad} is the advection time, c{sub 0} is the initial concentration in the medium, m{sub 0} is the 0th moment of the injection pulse; and t{sub a} is the mean residence time in the immobile domain (i.e., the characteristic mass transfer time). The function g is proportional to the residence time distribution in the immobile domain, the authors tabulate g for many geometries, including several distributed (multirate) models of mass transfer. Using this expression they examine the behavior of late-time concentration for a number of mass transfer models. One key results is that if rate-limited mass transfer causes the BTC to behave as a power-law at late-time (i.e., c {approximately} t{sup {minus}k}), then the underlying density function of rate coefficients must also be a power-law with the form a{sup k{minus}}, as a {r_arrow}0. This is true for both density functions of first-order and diffusion rate coefficients. BTCs with k < 3 persisting to the end of the experiment indicate a mean residence time longer than the experiment and possibly infinite, and also suggest an effective rate coefficient that is either undefined or changes as a function of observation time. They apply their analysis to breakthrough curves from Single-Well Injection-Withdrawal tests at the Waste Isolation Pilot Plant, New Mexico.

  19. Accuracy of a Diagnostic Algorithm to Diagnose Breakthrough Cancer Pain as Compared With Clinical Assessment.

    Science.gov (United States)

    Webber, Katherine; Davies, Andrew N; Cowie, Martin R

    2015-10-01

    Breakthrough cancer pain (BTCP) is a heterogeneous condition, and there are no internationally agreed standardized criteria to diagnose it. There are published algorithms to assist with diagnosis, but these differ in content. There are no comparative data to support use. To compare the diagnostic ability of a simple algorithm against a comprehensive clinical assessment to diagnose BTCP and to assess if verbal rating descriptors can adequately discriminate controlled background pain. Patients with cancer pain completed a three-step algorithm with a researcher to determine if they had controlled background pain and BTCP. This was followed by a detailed pain consultation with a clinical specialist who was blinded to the algorithm results and determined an independent pain diagnosis. The sensitivity, specificity, and positive and negative predictive values were calculated for the condition of BTCP. Further analysis determined which verbal pain severity descriptors corresponded with the condition of controlled background pain. The algorithm had a sensitivity of 0.54 and a specificity of 0.76 in the identification of BTCP. The positive predictive value was 0.7, and the negative predictive value was 0.62. The sensitivity of a background pain severity rating of mild or less to accurately categorize controlled background pain was 0.69 compared with 0.97 for severity of moderate or less; however, this was balanced by a higher specificity rating for mild or less, 0.78 compared with 0.2. The diagnostic breakthrough pain algorithm had a good positive predictive value but limited sensitivity using a cutoff score of "mild" to define controlled background pain. When the cutoff level was changed to moderate, the sensitivity increased, but specificity reduced. A comprehensive clinical assessment remains the preferred method to diagnose BTCP. Copyright © 2015 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  20. Accord on “Fire and Building Safety in Bangladesh”: A Breakthrough Agreement?

    Directory of Open Access Journals (Sweden)

    Zillur Rahman

    2014-03-01

    Full Text Available This discussion aims to review the emergence of the “Accord on Fire and Building Safety in Bangladesh” signed on May 13, 2013, and evaluate if it is an international agreement “breakthrough”. The Accord is signed not only by the global clothing brands and national garment unions but also by international trade union organizations, which is a new development. This raises a question: could this agreement set a new international negotiating precedence in industrial relations between transnational corporations and international trade union organizations? In Bangladesh, globalization has played an important role for booming garment industries. Yet, lack of workers’ rights, weak safety situations, and poor working conditions have continuously been reported. Local and international solidarity movements and garment workers’ welfare associations have been emphasizing workers’ rights and better and safer working environments in workplaces since the beginning of the 1990s. However, their voices were not highly considered even there were some initiatives. Following the ‘Rana Plaza’ garment factory building collapse in April 2013, one of the world’s worst industrial accidents, with more than 1,100 dead workers, some strong measures have been taken—one of these, signing the ‘Accord on Fire and Building Safety in Bangladesh’. This is a strong achievement of a long struggle to take collective action for improving the safety in garment factories in Bangladesh. Although the Accord is understood as a game changer or breakthrough in relation to national and international agreements, do we really know yet if it is a breakthrough or not when it comes to its implementation?

  1. Photogravimagnetic assists of light sails: a mixed blessing for Breakthrough Starshot?

    Science.gov (United States)

    Forgan, Duncan H.; Heller, René; Hippke, Michael

    2018-03-01

    Upon entering a star system, light sails are subject to both gravitational forces and radiation pressure, and can use both in concert to modify their trajectory. Moreover, stars possess significant magnetic fields, and if the sail is in any way charged, it will feel the Lorentz force also. We investigate the dynamics of so-called `photogravimagnetic assists' of sailcraft around α Centauri A, a potential first destination en route to Proxima Centauri (the goal of the Breakthrough Starshot programme). We find that a 10-m2 sail with a charge-to-mass ratio of around 10 μC g-1 or higher will need to take account of magnetic field effects during orbital manoeuvres. The magnetic field can provide an extra source of deceleration and deflection, and allow capture on to closer orbits around a target star. However, flipping the sign of the sailcraft's charge can radically change resulting trajectories, resulting in complex loop-de-loops around magnetic field lines and essentially random ejection from the star system. Even on well-behaved trajectories, the field can generate off-axis deflections at α Centauri that, while minor, can result in very poor targeting of the final destination (Proxima) post-assist. Fortunately for Breakthrough Starshot, nanosails are less prone to charging en route than their heavier counterparts, but can still accrue relatively high charge at both the origin and destination, when travelling at low speeds. Photogravimagnetic assists are highly non-trivial, and require careful course correction to mitigate against unwanted changes in trajectory.

  2. Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs.

    Science.gov (United States)

    Lantis, A C; Ames, M K; Atkins, C E; DeFrancesco, T C; Keene, B W; Werre, S R

    2015-02-01

    Pilot studies in our laboratory revealed that furosemide-induced renin-angiotensin-aldosterone system (RAAS) activation was not attenuated by the subsequent co-administration of benazepril. This study was designed to evaluate the effect of benazepril on angiotensin-converting enzyme (ACE) activity and furosemide-induced circulating RAAS activation. Our hypothesis was that benazepril suppression of ACE activity would not suppress furosemide-induced circulating RAAS activation, indicated by urinary aldosterone concentration. Ten healthy hound dogs were used in this study. The effect of furosemide (2 mg/kg p.o., q12h; Group F; n = 5) and furosemide plus benazepril (1 mg/kg p.o., q24h; Group FB; n = 5) on circulating RAAS was determined by plasma ACE activity, 4-6 h posttreatment, and urinary aldosterone to creatinine ratio (UAldo:C) on days -1, -2, 1, 3, and 7. There was a significant increase in the average UAldo:C (μg/g) after the administration of furosemide (Group F baseline [average of days -1 and -2] UAldo:C = 0.41, SD 0.15; day 1 UAldo:C = 1.1, SD 0.56; day 3 UAldo:C = 0.85, SD 0.50; day 7 UAldo:C = 1.1, SD 0.80, P Benazepril suppressed ACE activity (U/L) in Group FB (Group FB baseline ACE = 16.4, SD 4.2; day 1 ACE = 3.5, SD 1.4; day 3 ACE = 1.6, SD 1.3; day 7 ACE = 1.4, SD 1.4, P Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape). This is particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy. © 2014 John Wiley & Sons Ltd.

  3. Breakthrough and prospect of shale gas exploration and development in China

    Directory of Open Access Journals (Sweden)

    Dazhong Dong

    2016-01-01

    Full Text Available In the past five years, shale gas exploration and development has grown in a leaping-forward way in China. Following USA and Canada, China is now the third country where industrial shale gas production is realized, with the cumulative production exceeding 60 × 108 m3 until the end of 2015. In this paper, the main achievements of shale gas exploration and development in China in recent years were reviewed and the future development prospect was analyzed. It is pointed out that shale gas exploration and development in China is, on the whole, still at its early stage. Especially, marine shale gas in the Sichuan Basin has dominated the recent exploration and development. For the realization of shale gas scale development in China, one key point lies in the breakthrough and industrial production of transitional facies and continental facies shale gas. Low–moderate yield of shale gas wells is the normal in China, so it is crucial to develop key exploration and development technologies. Especially, strictly controlling single well investment and significantly reducing cost are the important means to increase shale gas exploration and development benefits. And finally, suggestions were proposed in five aspects. First, continuously strengthen theoretical and technical researches, actively carry out appraisal on shale gas “sweet spots”, and gradually accumulate development basis. Second, stress on primary evaluation of exploration and development, highlight the effective implementation of shale gas resources, and control the rhythm of appraisal drilling and productivity construction. Third, highlight fine description and evaluation of shale gas reservoirs and increase the overall development level. Fourth, intensify the research on exploration and development technologies in order to stand out simple and practical technologies with low costs. And fifth, summarize the experiences in fast growth of shale gas exploration and development, highlight

  4. Measures for simultaneous minimization of alkali related operating problems, Phase 2; Aatgaerder foer samtidig minimering av alkalirelaterade driftproblem, Etapp 2. Ramprogram

    Energy Technology Data Exchange (ETDEWEB)

    Gyllenhammar, Marianne; Herstad Svaerd, Solvie; Davidsson, Kent; Aamand, Lars-Erik; Steenari, Britt-Marie; Folkeson, Nicklas; Pettersson, Jesper; Svensson, Jan-Erik; Boss, Anna; Johansson, Linda; Kassman, Haakan

    2007-12-15

    Combustion of an increasing amount of biofuel and waste woods has resulted in certain environmental advantages, including decreased emissions of fossil CO{sub 2}, SO{sub 2} and metals. On the other hand, a number of chloride and alkali related operational problems have occurred which are related to combustion of these fuels. Alkali related operational problems have been studied in a project consisting of two parts. The overall scope has been to characterise the operational problems and to study measures to minimise them. The first part was reported in Vaermeforsk report 997. In part two, additional measures have been included in the test plan and initial corrosion has been studied linked to the different measures. The tests have also in part two been carried out at the 12 MW CFB boiler at Chalmers. The effect of the selected measures has been investigated concerning both deposit formation and bed agglomeration, and at the same time emissions and other operational conditions were characterised. The second part of the project has among other things focused on: To investigate measures which decrease the content of alkali and chloride in the deposits, and consequently decrease the risk for corrosion (by investigating the initial corrosion). Focus was also on trying to explain favourable effects. To investigate if it is possible to combine a rather low dosage of kaolin and injection of ammonium sulphate. This was done in order to reduce both bed agglomeration and problems from deposits during combustion of fuels rich in chlorine. To investigate if co-combustion with sewage sludge, de-inking sludge or peat with high ash content, could give similar advantages as conventional additives. Investigate if ash from PFBC (coal ash and dolomite) is possible to use as an alternative bed material. In the reference case, straw pellets were co-combusted together with wood pellets. This fuel mixture gave high alkali and chlorine contents. Alkali was in surplus of chlorine. The

  5. Analytic approach to the relativistic problem of constructing effective nucleon-nucleon and pion-nucleon interaction operators at low and intermediate energies

    International Nuclear Information System (INIS)

    Safronov, A.N.; Safronov, A.A.

    2006-01-01

    Full text: A nonperturbative character of QCD at low and intermediate energies generates serious mathematical difficulties in describing the dynamics of hadron-hadron interactions in terms quark-gluon degrees of freedom. Therefore much effort has gone in past years into developing QCD-motivated approaches that formulate the theory of strong interaction in terms of hadron degrees of freedom. The path-integral technique together with idea of spontaneous chiral-symmetry breaking leads to Effective Field Theory (EFT) [1]. Unfortunately EFT can be applied to description of hadron-hadron interactions only at very low energies. On the other hand, meson theories of nuclear forces have long since been used to describe the properties of nucleon systems and scattering processes. Now it is not quite clear, up to what distances the meson-exchange pattern of nuclear forces is valid. Recently the new relativistic approach to the problem of constructing effective hadron-hadron interaction operators has been proposed [2-4] on the basis of analytic S-matrix theory and Gelfand-Levitan-Marchenko-Martin methods for solving the inverse quantum scattering problem. In this approach effective potential is defined as a local operator in a partial-wave equation of the quasipotential type such that it generates on-shell relativistic (Feynman) scattering amplitude that has required discontinuities at dynamical cuts. The discontinuities of partial-wave amplitudes are determined by model-independent quantities (renormalized vertex constants and amplitudes of subprocesses involving on-mass-shell particles off the physical region) and can be calculated by methods of relativistic quantum field theory within various dynamical approaches. In particular, EFT can be used to calculate the discontinuities across dynamical-cut segments closest to the physical region. In [2-4] we have examined the basic features of the proposed approach. Attention has been given primarily to analyzing the new mechanism of

  6. The Petsamo-Kirkenes Operation: Soviet Breakthrough and Pursuit in the Arctic, October 1944 (Leavenworth Papers, Number 17)

    Science.gov (United States)

    1989-09-01

    A road also joined Salmiiarvi, Nikel , and Luostari. East of Petsamo and Luostari were three trunk roads that supported the three division-size...allowed for all-around observation and fire and was surrounded by barbed- wire obstacles and minefields, as needed. The size of each strongpoint...positions guarded the approaches to Petsamo and Luostari. Additional defensive positions protected the mines at Nikel , the port at Liinakhamari

  7. Photonic quantum digital signatures operating over kilometer ranges in installed optical fiber

    Science.gov (United States)

    Collins, Robert J.; Fujiwara, Mikio; Amiri, Ryan; Honjo, Toshimori; Shimizu, Kaoru; Tamaki, Kiyoshi; Takeoka, Masahiro; Andersson, Erika; Buller, Gerald S.; Sasaki, Masahide

    2016-10-01

    The security of electronic communications is a topic that has gained noteworthy public interest in recent years. As a result, there is an increasing public recognition of the existence and importance of mathematically based approaches to digital security. Many of these implement digital signatures to ensure that a malicious party has not tampered with the message in transit, that a legitimate receiver can validate the identity of the signer and that messages are transferable. The security of most digital signature schemes relies on the assumed computational difficulty of solving certain mathematical problems. However, reports in the media have shown that certain implementations of such signature schemes are vulnerable to algorithmic breakthroughs and emerging quantum processing technologies. Indeed, even without quantum processors, the possibility remains that classical algorithmic breakthroughs will render these schemes insecure. There is ongoing research into information-theoretically secure signature schemes, where the security is guaranteed against an attacker with arbitrary computational resources. One such approach is quantum digital signatures. Quantum signature schemes can be made information-theoretically secure based on the laws of quantum mechanics while comparable classical protocols require additional resources such as anonymous broadcast and/or a trusted authority. Previously, most early demonstrations of quantum digital signatures required dedicated single-purpose hardware and operated over restricted ranges in a laboratory environment. Here, for the first time, we present a demonstration of quantum digital signatures conducted over several kilometers of installed optical fiber. The system reported here operates at a higher signature generation rate than previous fiber systems.

  8. Application of the rainfall infiltration breakthrough (RIB) model for groundwater recharge estimation in west coastal South Africa

    CSIR Research Space (South Africa)

    Sun, X

    2013-04-01

    Full Text Available level fluctuations (WLF) on a monthly basis was proposed in the rainfall infiltration breakthrough (RIB) model for the purpose of groundwater recharge estimation. In this paper, the physical meaning of parameters in the CRD and previous RIB models...

  9. Busted Butte Phase 2: Introduction and Analytical Modeling of Nonreactive Tracer and Lithium Breakthrough

    International Nuclear Information System (INIS)

    Turin, H.J.; Soll, W.E.

    2002-01-01

    The Busted Butte Unsaturated-Zone Transport Test Facility is located approximately 8 km southeast of Yucca Mountain, and was designed to address uncertainties associated with flow and transport in the UZ site-process models for Yucca Mountain. Busted Butte Phase 2 consisted of a 10m x 10m x 7m test block. From July 1988 through October 2000, complex tracer mixtures were injected continuously at 77 discrete points located along eight parallel 10-m boreholes arranged in two horizontal planes. In August 1999, iodide was added to the tracer mixture to explore the effects of initial hydraulic transients. During the course of the experiment, porewater samples were collected at regular intervals using sorbing-paper collection pads, emplaced into fifteen horizontal and inclined 10-m collection boreholes, oriented perpendicular to the injection boreholes. Potential travel distances ranged from 20 cm to over 500 cm. Nonreactive tracer and weakly sorbing lithium breakthrough was observed at most of the collection points during the injection period. Following termination of injection, approximately 800 rock samples were collected using overcore and mineback techniques, and analyzed for tracer concentration. Rock analyses are discussed in a subsequent paper. To complement complex 3-dimensional finite-element modeling of the entire block, bromide, iodide, and lithium breakthrough onto the collection pads has been modeled with CXTFIT. This simple 1-dimensional analytical code uses a non-linear curve-fitting routine to estimate transport parameters including apparent velocity, dispersivity, and field retardation factors. Preliminary results show that: (1) Bromide and iodide behaved similarly, despite the fact that bromide was injected in a strongly transient flow field, while iodide injection began after flow had approached steady state conditions. (2) With the exception of the closest collection points, tracer velocities remained relatively constant, indicating that transport was

  10. Recent breakthroughs and themes in hydrology, from climate to the water-food-energy nexus

    Science.gov (United States)

    Montanari, A.

    2017-12-01

    The last decades marked a significant change in geosciences. Increasing communication, observations, computing capabilities and opportunities to make dissemination stimulated a rapid increase of the number of publications and scientific forums. On the one hand this development is undoubtedly positive. In fact, it provides more and more opportunities to young and experienced scientists to elaborate innovative ideas and to establish cooperation. On the other hand, the proliferation of information, communication and publications makes the identification of key ideas and contributions definitely more challenging. Notwithstanding the above development, Water Resources Research (WRR) provides an ideal perspective to elaborate a picture of recent breakthroughs in hydrology. In fact, despite the increasing number of submissions and the progress of time, WRR kept a rigorous attitude to assess manuscripts by evaluating their relevance to emerging environmental and societal challenges.To get a long term perspective of breakthroughs in hydrology, it is interesting to compare the two anniversary special sections published so far in WRR, namely, the 50th anniversary special section "Legacy and perspectives for the science of hydrology", and "Trends and Directions in Hydrology", that was edited by Steven Burges in 1986 to celebrate the 20th anniversary of the journal. The above comparison highlights that the traditional break-up of hydrology into sub-disciplines, each focusing on separate components of the water cycle, has given way to a more interconnected, interdisciplinary research on a wide range of spatial and temporal scales, and interactions between water, society, earth and biological systems.This talk will present a voyage through the WRR history to highlight recent advances and topical themes. An attempt to develop a vision for the future of WRR and hydrology will be presented. Water will become more and more the regulator of social dynamics, including economy, politics

  11. Predicting trace organic compound breakthrough in granular activated carbon using fluorescence and UV absorbance as surrogates.

    Science.gov (United States)

    Anumol, Tarun; Sgroi, Massimiliano; Park, Minkyu; Roccaro, Paolo; Snyder, Shane A

    2015-06-01

    This study investigated the applicability of bulk organic parameters like dissolved organic carbon (DOC), UV absorbance at 254 nm (UV254), and total fluorescence (TF) to act as surrogates in predicting trace organic compound (TOrC) removal by granular activated carbon in water reuse applications. Using rapid small-scale column testing, empirical linear correlations for thirteen TOrCs were determined with DOC, UV254, and TF in four wastewater effluents. Linear correlations (R(2) > 0.7) were obtained for eight TOrCs in each water quality in the UV254 model, while ten TOrCs had R(2) > 0.7 in the TF model. Conversely, DOC was shown to be a poor surrogate for TOrC breakthrough prediction. When the data from all four water qualities was combined, good linear correlations were still obtained with TF having higher R(2) than UV254 especially for TOrCs with log Dow>1. Excellent linear relationship (R(2) > 0.9) between log Dow and the removal of TOrC at 0% surrogate removal (y-intercept) were obtained for the five neutral TOrCs tested in this study. Positively charged TOrCs had enhanced removals due to electrostatic interactions with negatively charged GAC that caused them to deviate from removals that would be expected with their log Dow. Application of the empirical linear correlation models to full-scale samples provided good results for six of seven TOrCs (except meprobamate) tested when comparing predicted TOrC removal by UV254 and TF with actual removals for GAC in all the five samples tested. Surrogate predictions using UV254 and TF provide valuable tools for rapid or on-line monitoring of GAC performance and can result in cost savings by extended GAC run times as compared to using DOC breakthrough to trigger regeneration or replacement. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. FRB121102: First detection across 5 - 8 GHz and spectral properties from the Breakthrough Listen instrument

    Science.gov (United States)

    Gajjar, Vishal; Siemion, Andrew; MacMohan, David; Croft, Steve; Hellbourg, Greg; Isaacson, Howard; Enriquez, J. Emilio; Price, Daniel; Lebofsky, Matt; De Boer, David; Werthimer, Dan; Hickish, Jack; Brinkman, Casey; Chatterjee, Shami; Ransom, Scott M.; Law, Casey; Hessels, Jason W. T.; Cordes, Jim; Spitler, Laura; Lynch, Ryan; McLaughlin, Maura; Scholz, Paul; Marcote, Benito; Bower, Geoffrey C.; Tendulkar, Shriharsh

    2018-01-01

    Fast Radio Bursts (FRBs) are some of the most energetic and enigmatic events in the Universe. The origin of these sources is among the most challenging questions of modern-day astrophysics. Thus, it is imperative to understand the properties of these bursts across a range of radio frequencies. Among the known FRBs, FRB121102 is the only source known to show repeated bursts [Spitler et al., Nature, 531, 7593 202-205, 2016], which can allow a detailed investigation of various origin models. In August 2017, we initiated a campaign observing FRB 121102 using the Breakthrough Listen Digital Backend with the C-band receiver at the Robert C. Byrd Green Bank Telescope (GBT). We recorded baseband voltage data across 5.4 GHz of bandwidth, completely covering the C-band receiver's nominal 4-8 GHz band [MacMahon et al. arXiv:1707.06024v2]. The recorded data were searched for dispersed pulses consistent with the known dispersion measure of FRB 121102 (557 pc cm-3) using high-speed GPU software tools. We detected 21 bursts above our detection threshold of 6 sigmas in the first 60-minutes, out of which 18 occurred in the first 30-minutes only. To our knowledge, this is the highest event rate seen for FRB121102 at any observing frequency. These observations are the highest frequency and widest bandwidth detection of bursts from FRB 121102 (or any other FRB) obtained to-date. We note that individual bursts show marked changes in spectral extent ranging from hundreds of MHz to several GHz. We have used high frequency dynamic spectra of these bursts to estimate the characteristic scintillation bandwidth and correlation time-scale. We also found distinctive temporal structures, separated by a few milliseconds, in three of the strongest bursts, with each sub-structure exhibiting varied spectral features. We will discuss our findings and how these detections of FRB 121102 around 8 GHz opens up a new regime in scrutinizing various origin models. We will also highlight the unique

  13. Reduced ash-related operational problems by co-combustion peat and agricultural fuels; Minskade askrelaterade driftsproblem genom inblandning av torv i aakerbraenslen

    Energy Technology Data Exchange (ETDEWEB)

    Oehman, Marcus; Bostroem, Dan; Skoglund, Nils; Grimm, Alejandro; Boman, Christoffer; Kofod-Hansen, Marie

    2010-06-15

    The objectives of the project were: To determine the admixing levels for different peat classes to various energy crops (straw, Salix and Reed canary grass) that are required to reach positive effects regarding slagging, deposit formation/(high temperature corrosion) and bed agglomeration; and, To demonstrate the possibilities to reduce the occurrence of ash related operational problems in combustion of energy crops upon admixing peat. Operational experiences and research of effects of co-firing peat and energy crops are scarce. Some previous tests in bench scale indicated though, on a strong reduction of the agglomeration tendency and lowering of the agglomeration temperature for straw and Salix at a peat admixing level corresponding to 15 - 20 weight% (on DS basis). A reduction in the amount of emitted fine particles was also observed in these experiments. However, care must be taken in the choice of peat. Some Carex dominated peats with high Si contents may cause problems with slagging. Another conclusion from the mentioned bench scale tests was that peats with relative high Ca/Si ratios should be selected to minimize the risk of slagging and bed agglomeration. Thermochemical modelling was performed to determine the effects of peat admixture, on slagging-, deposit formation- (corrosion)- and bed agglomeration tendencies during combustion of straw, willow and reed canary grass with high and low ash content. These results and previously conducted bench scale experiments were used as a basis for determining combinations of fuel and peat admixtures for the demonstration experiments. The calculations were performed with admixing levels of 0-, 5-, 15, 25-, and 40 weight% (on DS basis) of four peat samples to the investigated four crop fuels. The used peat samples were typical carex-containing Swedish peat with differences in e.g. silicon-, calcium- and sulfur contents. A number of the model calculations were qualitatively validated against previously conducted

  14. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.

    Science.gov (United States)

    Adimoelja, A

    2000-01-01

    Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have developed from traditional herbs. Phytochemicals focus their mechanism of healing action to the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscine to DHEA (De-Hydro-Epi-Androsterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component Protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent results found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.

  15. Do It Yourself (DIY) Earth Science Collaboratories Using Best Practices and Breakthrough Technologies

    Science.gov (United States)

    Stephan, E.

    2017-12-01

    The objective of published earth science study data results and literature on the Web should be to provide a means to integrate discoverable science resources through an open collaborative-Web. At the core of any open science collaborative infrastructure is the ability to discover, manage and ultimately use relevant data accessible to the collaboration. Equally important are the relationships between people, applications, services, and publications, which capture critical contextual knowledge that enable their effective use. While contributions of either irreproducible or costly data can be a great asset the inability of users being able to use the data intelligently or make sense of it, makes these investments not usable. An ability to describe ad-hoc discoverable usage methodologies, provide feedback to data producers, and identify and cite data in a systematic way by leveraging existing Web-enabled off the shelf technology is needed. Fortunately many break-through advancements in data publication best practices and government, open source, and commercial investments support consumers who can provide feedback, share experiences, and contribute back to the earth science ecosystem.

  16. The Breakthrough Listen Initiative and the Future of the Search for Intelligent Life

    Science.gov (United States)

    Enriquez, J. Emilio; Siemion, Andrew; Croft, Steve; Hellbourg, Greg; Lebofsky, Matt; MacMahon, David; Price, Danny; DeBoer, David; Werthimer, Dan

    2017-05-01

    Unprecedented recent results in the fields of exoplanets and astrobiology have dramatically increased the interest in the potential existence of intelligent life elsewhere in the galaxy. Additionally, the capabilities of modern Searches for Extraterrestrial Intelligence (SETI) have increased tremendously. Much of this improvement is due to the ongoing development of wide bandwidth radio instruments and the Moore's Law increase in computing power over the previous decades. Together, these instrumentation improvements allow for narrow band signal searches of billions of frequency channels at once.The Breakthrough Listen Initiative (BL) was launched on July 20, 2015 at the Royal Society in London, UK with the goal to conduct the most comprehensive and sensitive search for advanced life in humanity's history. Here we detail important milestones achieved during the first year and a half of the program. We describe the key BL SETI surveys and briefly describe current facilities, including the Green Bank Telescope, the Automated Planet Finder and the Parkes Observatory. We also mention the ongoing and potential collaborations focused on complementary sciences, these include pulse searches of pulsars and FRBs, as well as astrophysically powered radio emission from stars targeted by our program.We conclude with a brief view towards future SETI searches with upcoming next-generation radio facilities such as SKA and ngVLA.

  17. Stem cell-derived kidney cells and organoids: Recent breakthroughs and emerging applications.

    Science.gov (United States)

    Chuah, Jacqueline Kai Chin; Zink, Daniele

    The global rise in the numbers of kidney patients and the shortage in transplantable organs have led to an increasing interest in kidney-specific regenerative therapies, renal disease modelling and bioartificial kidneys. Sources for large quantities of high-quality renal cells and tissues would be required, also for applications in in vitro platforms for compound safety and efficacy screening. Stem cell-based approaches for the generation of renal-like cells and tissues would be most attractive, but such methods were not available until recently. This situation has drastically changed since 2013, and various protocols for the generation of renal-like cells and precursors from pluripotent stem cells (PSC) have been established. The most recent breakthroughs were related to the establishment of various protocols for the generation of PSC-derived kidney organoids. In combination with recent advances in genome editing, bioprinting and the establishment of predictive renal screening platforms this results in exciting new possibilities. This review will give a comprehensive overview over current PSC-based protocols for the generation of renal-like cells, precursors and organoids, and their current and potential applications in regenerative medicine, compound screening, disease modelling and bioartificial organs. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Breakthrough reactions of iodinated and gadolinium contrast media after oral steroid premedication protocol.

    Science.gov (United States)

    Jingu, Akiko; Fukuda, Junya; Taketomi-Takahashi, Ayako; Tsushima, Yoshito

    2014-10-06

    Adverse reactions to iodinated and gadolinium contrast media are an important clinical issue. Although some guidelines have proposed oral steroid premedication protocols to prevent adverse reactions, some patients may have reactions to contrast media in spite of premedication (breakthrough reaction; BTR).The purpose of this study was to assess the frequency, type and severity of BTR when following an oral steroid premedication protocol. All iodinated and gadolinium contrast-enhanced radiologic examinations between August 2011 and February 2013 for which the premedication protocol was applied in our institution were assessed for BTRs. The protocol was applied to a total of 252 examinations (153 patients, ages 15-87 years; 63 males, 90 females). Of these, 152 were for prior acute adverse reactions to contrast media, 85 were for a history of bronchial asthma, and 15 were for other reasons. There were 198 contrast enhanced CTs and 54 contrast enhanced MRIs. There were nine BTR (4.5%) for iodinated contrast media, and only one BTR (1.9%) for gadolinium contrast media: eight were mild and one was moderate. No patient who had a mild index reaction (IR) had a severe BTR. Incidence of BTRs when following the premedication protocol was low. This study by no means proves the efficacy of premedication, but provides some support for following a premedication protocol to improve safety of contrast-enhanced examinations when prior adverse reactions are mild, or when there is a history of asthma.

  19. Breakthrough reactions of iodinated and gadolinium contrast media after oral steroid premedication protocol

    International Nuclear Information System (INIS)

    Jingu, Akiko; Fukuda, Junya; Taketomi-Takahashi, Ayako; Tsushima, Yoshito

    2014-01-01

    Adverse reactions to iodinated and gadolinium contrast media are an important clinical issue. Although some guidelines have proposed oral steroid premedication protocols to prevent adverse reactions, some patients may have reactions to contrast media in spite of premedication (breakthrough reaction; BTR). The purpose of this study was to assess the frequency, type and severity of BTR when following an oral steroid premedication protocol. All iodinated and gadolinium contrast-enhanced radiologic examinations between August 2011 and February 2013 for which the premedication protocol was applied in our institution were assessed for BTRs. The protocol was applied to a total of 252 examinations (153 patients, ages 15–87 years; 63 males, 90 females). Of these, 152 were for prior acute adverse reactions to contrast media, 85 were for a history of bronchial asthma, and 15 were for other reasons. There were 198 contrast enhanced CTs and 54 contrast enhanced MRIs. There were nine BTR (4.5%) for iodinated contrast media, and only one BTR (1.9%) for gadolinium contrast media: eight were mild and one was moderate. No patient who had a mild index reaction (IR) had a severe BTR. Incidence of BTRs when following the premedication protocol was low. This study by no means proves the efficacy of premedication, but provides some support for following a premedication protocol to improve safety of contrast-enhanced examinations when prior adverse reactions are mild, or when there is a history of asthma

  20. Tracking tracer breakthrough in the hyporheic zone using time‐lapse DC resistivity, Crabby Creek, Pennsylvania

    Science.gov (United States)

    Nyquist, Jonathan E.; Toran, Laura; Fang, Allison C.; Ryan, Robert J.; Rosenberry, Donald O.

    2010-01-01

    Characterization of the hyporheic zone is of critical importance for understanding stream ecology, contaminant transport, and groundwater‐surface water interaction. A salt water tracer test was used to probe the hyporheic zone of a recently re‐engineered portion of Crabby Creek, a stream located near Philadelphia, PA. The tracer solution was tracked through a 13.5 meter segment of the stream using both a network of 25 wells sampled every 5–15 minutes and time‐lapse electrical resistivity tomographs collected every 11 minutes for six hours, with additional tomographs collected every 100 minutes for an additional 16 hours. The comparison of tracer monitoring methods is of keen interest because tracer tests are one of the few techniques available for characterizing this dynamic zone, and logistically it is far easier to collect resistivity tomographs than to install and monitor a dense network of wells. Our results show that resistivity monitoring captured the essential shape of the breakthrough curve and may indicate portions of the stream where the tracer lingered in the hyporheic zone. Time‐lapse resistivity measurements, however, represent time averages over the period required to collect a tomographic data set, and spatial averages over a volume larger than captured by a well sample. Smoothing by the resistivity data inversion algorithm further blurs the resulting tomograph; consequently resistivity monitoring underestimates the degree of fine‐scale heterogeneity in the hyporheic zone.

  1. Point Climat no. 33 'International Climate Negotiations - COP 19: do not underestimate the MRV breakthrough'

    International Nuclear Information System (INIS)

    Dupont, Marion; Morel, Romain; Bellassen, Valentin; Deheza, Mariana

    2013-01-01

    Among the publications of CDC Climat Research, 'Climate Briefs' presents, in a few pages, hot topics in climate change policy. This issue addresses the following points: For those who expect 'binding' emission reductions targets in the future international climate agreement to be signed in Paris in 2015, the Warsaw Conference (November 11 to 23, 2013) yielded as much progress as it could. That means little beyond a timetable. However, for those who consider the UNFCCC as the depository of common tools on the monitoring, reporting and verification (MRV) of emissions, actions and financing, Warsaw represents a major breakthrough. For the first time, developing countries - at least those wishing to access climate finance for forests - will abide by MRV procedures similar to those governing the greenhouse gas inventories of industrialized countries. Forestry may be seen as a first sectoral NAMA, and it would be difficult to ignore the Warsaw decisions for the future definition of MRV procedures of NAMAs. In spite of the establishment of the Warsaw International Mechanism for Loss and Damage, low outputs on other issues show that achieving an agreement at COP 21 will require significant political progress during the next 15 months

  2. Engineering excellence in breakthrough biomedical technologies: bioengineering at the University of California, Riverside.

    Science.gov (United States)

    Schultz, Jane S; Rodgers, V G J

    2012-07-01

    The Department of Bioengineering at the University of California, Riverside (UCR), was established in 2006 and is the youngest department in the Bourns College of Engineering. It is an interdisciplinary research engine that builds strength from highly recognized experts in biochemistry, biophysics, biology, and engineering, focusing on common critical themes. The range of faculty research interests is notable for its diversity, from the basic cell biology through cell function to the physiology of the whole organism, each directed at breakthroughs in biomedical devices for measurement and therapy. The department forges future leaders in bioengineering, mirroring the field in being energetic, interdisciplinary, and fast moving at the frontiers of biomedical discoveries. Our educational programs combine a solid foundation in bio logical sciences and engineering, diverse communication skills, and training in the most advanced quantitative bioengineering research. Bioengineering at UCR also includes the Bioengineering Interdepartmental Graduate (BIG) program. With its slogan Start-Grow-Be-BIG, it is already recognized for its many accomplishments, including being third in the nation in 2011 for bioengineering students receiving National Science Foundation graduate research fellowships as well as being one of the most ethnically inclusive programs in the nation.

  3. Familial concordance for age at natural menopause: results from the Breakthrough Generations Study.

    Science.gov (United States)

    Morris, Danielle H; Jones, Michael E; Schoemaker, Minouk J; Ashworth, Alan; Swerdlow, Anthony J

    2011-09-01

    Existing estimates of the heritability of menopause age have a wide range. Furthermore, few studies have analyzed to what extent familial similarities might reflect shared environment, rather than shared genes. We therefore analyzed familial concordance for age at natural menopause and the effects of shared genetic and environmental factors on this concordance. Participants were 2,060 individuals comprising first-degree relatives, aged 31 to 90 years, and participating in the UK Breakthrough Generations Study. Menopause data were collected using a self-administered questionnaire and analyzed using logistic regression and variance-components models. Women were at an increased risk of early menopause (≤45 y) if their mother (odds ratio, 6.2; P menopause. Likewise, women had an increased risk of late menopause (≥54 y) if their relative had had a late menopause (mother: odds ratio, 6.1; P menopause age attributed to environmental factors shared by sisters. We confirm that early menopause aggregates within families and show, for the first time, that there is also strong familial concordance for late menopause. Both genes and shared environment were the source of variation in menopause age. Past heritability estimates have not accounted for shared environment, and thus, the effect of genetic variants on menopause age may previously have been overestimated.

  4. Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline

    Directory of Open Access Journals (Sweden)

    Elise eDelage

    2013-12-01

    Full Text Available It has been known for more than a century that most of the plant cells are connected to their neighbors through membranous pores perforating the cell wall, namely plasmodesmata (PDs. The recent discovery of tunneling nanotubes (TNTs, thin membrane bridges established between distant mammalian cells, suggests that intercellular communication mediated through cytoplasmic continuity could be a conserved feature of eukaryotic organisms. Although TNTs differ from PDs in their formation and architecture, both are characterized by a continuity of the plasma membrane between two cells, delimiting a nanotubular channel supported by actin-based cytoskeleton. Due to this unusual membrane organization, lipids are likely to play critical roles in the formation and stability of intercellular conduits like TNTs and PDs, but also in regulating the transfer through these structures. While it is crucial for a better understanding of those fascinating communication highways, the study of TNT lipid composition and dynamics turned out to be extremely challenging. The present review aims to give an overview of the recent findings in this context. We will also discuss some of the promising imaging approaches, which might be the key for future breakthroughs in the field and could also benefit the research on PDs.

  5. Laboratory investigation and simulation of breakthrough curves in karst conduits with pools

    Science.gov (United States)

    Zhao, Xiaoer; Chang, Yong; Wu, Jichun; Peng, Fu

    2017-12-01

    A series of laboratory experiments are performed under various hydrological conditions to analyze the effect of pools in pipes on breakthrough curves (BTCs). The BTCs are generated after instantaneous injections of NaCl tracer solution. In order to test the feasibility of reproducing the BTCs and obtain transport parameters, three modeling approaches have been applied: the equilibrium model, the linear graphical method and the two-region nonequilibrium model. The investigation results show that pools induce tailing of the BTCs, and the shapes of BTCs depend on pool geometries and hydrological conditions. The simulations reveal that the two-region nonequilibrium model yields the best fits to experimental BTCs because the model can describe the transient storage in pools by the partition coefficient and the mass transfer coefficient. The model parameters indicate that pools produce high dispersion. The increased tailing occurs mainly because the partition coefficient decreases, as the number of pools increases. When comparing the tracer BTCs obtained using the two types of pools with the same size, the more appreciable BTC tails that occur for symmetrical pools likely result mainly from the less intense exchange between the water in the pools and the water in the pipe, because the partition coefficients for the two types of pools are virtually identical. Dispersivity values decrease as flow rates increase; however, the trend in dispersion is not clear. The reduced tailing is attributed to a decrease in immobile water with increasing flow rate. It provides evidence for hydrodynamically controlled tailing effects.

  6. Making Breakthroughs in the Turbulent Decade: China's Space Technology During the Cultural Revolution.

    Science.gov (United States)

    Li, Chengzhi; Zhang, Dehui; Hu, Danian

    2017-09-01

    This article discusses why Chinese space programs were able to develop to the extent they did during the turbulent decade of the Cultural Revolution (1966-1976). It first introduces briefly what China had accomplished in rocket and missile technology before the Cultural Revolution, including the establishment of a system for research and manufacturing, breakthroughs in rocket technology, and programs for future development. It then analyzes the harmful impacts of the Cultural Revolution on Chinese space programs by examining activities of contemporary mass factions in the Seventh Ministry of Machinery Industry. In the third section, this article presents the important developments of Chinese space programs during the Cultural Revolution and explores briefly the significance of these developments for the future and overall progress in space technology. Finally, it discusses the reasons for the series of developments of Chinese space technology during the Cultural Revolution. This article concludes that, although the Cultural Revolution generated certain harmful impacts on the development of Chinese space technology, the Chinese essentially accomplished their scheduled objectives in their space program, both because of the great support of top Chinese leaders, including the officially disgraced Lin Biao and the Gang of Four, and due to the implementation of many effective special measures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Mathematical modeling and experimental breakthrough curves of carbon dioxide adsorption on metal organic framework CPM-5.

    Science.gov (United States)

    Sabouni, Rana; Kazemian, Hossein; Rohani, Sohrab

    2013-08-20

    It is essential to capture carbon dioxide from flue gas because it is considered one of the main causes of global warming. Several materials and different methods have been reported for CO2 capturing including adsorption onto zeolites and porous membranes, as well as absorption in amine solutions. All such methods require high energy input and high cost. A new class of porous materials called Metal Organic Frameworks (MOFs) exhibited excellent performance in extracting carbon dioxide from a gas mixture. In this study, the breakthrough curves for the adsorption of carbon dioxide on CPM-5 (crystalline porous materials) were obtained experimentally and theoretically using a laboratory-scale fixed-bed column at different experimental conditions such as feed flow rate, adsorption temperature, and feed concentration. It was found that the CPM-5 has a dynamic CO2 adsorption capacity of 11.9 wt % (2.7 mmol/g) (corresponding to 8 mL/min, 298 K, and 25% v/v CO2). The tested CPM-5 showed an outstanding adsorption equilibrium capacity (e.g., 2.3 mmol/g (10.2 wt %) at 298 K) compared to other adsorbents, which can be considered as an attractive adsorbent for separation of CO2 from flue gas.

  8. Studies of aging and HV break down problems during development and operation of MSGC and GEM detectors for the inner tracking system of HERA-B

    International Nuclear Information System (INIS)

    Bagaturia, Y.; Baruth, O.; Dreis, H.B.; Eisele, F.; Gorbunov, I.; Gradl, S.; Gradl, W.; Hausmann, S.; Hildebrandt, M.; Hott, T.; Keller, S.; Krauss, C.; Lomonosov, B.; Negodaev, M.; Richter, C.; Robmann, P.; Schmidt, B.; Straumann, U.; Truoel, P.; Visbeck, S.; Walter, T.; Werner, C.; Werthenbach, U.; Zech, G.; Zeuner, T.; Ziegler, M.

    2002-01-01

    The results of 5 years of development of the inner tracking system of the HERA-B experiment and first experience from the data taking period of the year 2000 are reported. The system contains 184 chambers, covering a sensitive area of about (20x20) cm 2 each. The detector is based on microstrip gas counters (MSGCs) with diamond-like coated (DLC) glass wafers and gas electron multipliers (GEMs). The main problems in the development phase were gas discharges in intense hadron beams and aging in a high radiation dose environment. The observation of gas discharges which damage the electrode structure of the MSGC led to the addition of the GEM as a first amplification step. Spurious sparking at the GEM cannot be avoided completely. It does not affect the GEM itself but can produce secondary damage of the MSGC if the electric field between the GEM and the MSGC is above a threshold depending on the operation conditions. We observed that aging does not only depend on the dose but also on the spot size of the irradiated area. Ar-DME mixtures had to be abandoned whereas a mixture of 70% Ar and 30% CO 2 showed no serious aging effects up to about 40 mC/cm deposited charge on the anodes. X-ray measurements indicate that the DLC of the MSGC is deteriorated by the gas amplification process. As a consequence, long-term gain variations are expected. The Inner Tracker has successfully participated in the data taking at HERA-B during summer 2000

  9. Studies of aging and HV break down problems during development and operation of MSGC and GEM detectors for the inner tracking system of HERA-B

    Energy Technology Data Exchange (ETDEWEB)

    Bagaturia, Y.; Baruth, O.; Dreis, H.B.; Eisele, F.; Gorbunov, I.; Gradl, S.; Gradl, W.; Hausmann, S.; Hildebrandt, M.; Hott, T.; Keller, S.; Krauss, C.; Lomonosov, B.; Negodaev, M.; Richter, C.; Robmann, P.; Schmidt, B.; Straumann, U.; Truoel, P.; Visbeck, S.; Walter, T.; Werner, C.; Werthenbach, U.; Zech, G. E-mail: zech@physik.uni-siegen.de; Zeuner, T.; Ziegler, M

    2002-09-01

    The results of 5 years of development of the inner tracking system of the HERA-B experiment and first experience from the data taking period of the year 2000 are reported. The system contains 184 chambers, covering a sensitive area of about (20x20) cm{sup 2} each. The detector is based on microstrip gas counters (MSGCs) with diamond-like coated (DLC) glass wafers and gas electron multipliers (GEMs). The main problems in the development phase were gas discharges in intense hadron beams and aging in a high radiation dose environment. The observation of gas discharges which damage the electrode structure of the MSGC led to the addition of the GEM as a first amplification step. Spurious sparking at the GEM cannot be avoided completely. It does not affect the GEM itself but can produce secondary damage of the MSGC if the electric field between the GEM and the MSGC is above a threshold depending on the operation conditions. We observed that aging does not only depend on the dose but also on the spot size of the irradiated area. Ar-DME mixtures had to be abandoned whereas a mixture of 70% Ar and 30% CO{sub 2} showed no serious aging effects up to about 40 mC/cm deposited charge on the anodes. X-ray measurements indicate that the DLC of the MSGC is deteriorated by the gas amplification process. As a consequence, long-term gain variations are expected. The Inner Tracker has successfully participated in the data taking at HERA-B during summer 2000.

  10. Parabolic refractive X-ray lenses: a breakthrough in X-ray optics

    CERN Document Server

    Lengeler, B; Benner, B; Guenzler, T F; Kuhlmann, M; Tümmler, J; Simionovici, A S; Drakopoulos, M; Snigirev, A; Snigireva, I

    2001-01-01

    Refractive X-ray lenses, considered for a long time as unfeasible, have been realized with a rotational parabolic profile at our institute: The main features of the new lenses are: they focus in two directions and are free of spherical aberration. By varying the number of individual lenses in the stack the focal length can be chosen in a typical range from 0.5 to 2 m for photon energies between about 6 and 60 keV. The aperture of the lens is about 1 mm matching the angular divergence of undulator beams at 3d generation synchrotron radiation sources. They cope without problems with the heat load from the white beam of an undulator. Finally, they are easy to align and to operate. Refractive X-ray lenses can be used with hard X-rays in the same way as glass lenses can be used for visible light, if it is take into account that the numerical aperture is small (of the order 10 sup - sup 4). Being high-quality optical elements, the refractive X-ray lenses can be used for generating a focal spot in the mu m range wit...

  11. The Elder Problem

    Directory of Open Access Journals (Sweden)

    John W. Elder

    2017-03-01

    Full Text Available This paper presents an autobiographical and biographical historical account of the genesis, evolution and resolution of the Elder Problem. It begins with John W. Elder and his autobiographical story leading to his groundbreaking work on natural convection at Cambridge in the 1960’s. His seminal work published in the Journal of Fluid Mechanics in 1967 became the basis for the modern benchmark of variable density flow simulators that we know today as “The Elder Problem”. There have been well known and major challenges with the Elder Problem model benchmark—notably the multiple solutions that were ultimately uncovered using different numerical models. Most recently, it has been shown that the multiple solutions are indeed physically realistic bifurcation solutions to the Elder Problem and not numerically spurious artefacts. The quandary of the Elder Problem has now been solved—a major scientific breakthrough for fluid mechanics and for numerical modelling. This paper—records, reflections, reminiscences, stories and anecdotes—is an historical autobiographical and biographical memoir. It is the personal story of the Elder Problem told by some of the key scientists who established and solved the Elder Problem. 2017 marks the 50 year anniversary of the classical work by John W. Elder published in Journal of Fluid Mechanics in 1967. This set the stage for this scientific story over some five decades. This paper is a celebration and commemoration of the life and times of John W. Elder, the problem named in his honour, and some of the key scientists who worked on, and ultimately solved, it.

  12. Operation Amplifier

    NARCIS (Netherlands)

    Tetsuya, Saito; Nauta, Bram

    2011-01-01

    PROBLEM TO BE SOLVED: To provide an operation amplifier which improves power source voltage removal ratios while assuring phase compensation characteristics, and therefore can be realized with a small-scale circuit and low power consumption. SOLUTION: The operation amplifier comprises: a

  13. Operation Amplifier

    NARCIS (Netherlands)

    Tetsuya, S.; Nauta, Bram

    2007-01-01

    PROBLEM TO BE SOLVED: To provide an operation amplifier which improves power source voltage removal ratios while assuring phase compensation characteristics, and therefore can be realized with a small-scale circuit and low power consumption. ; SOLUTION: The operation amplifier comprises: a

  14. Operating systems

    CERN Document Server

    Tsichritzis, Dionysios C; Rheinboldt, Werner

    1974-01-01

    Operating Systems deals with the fundamental concepts and principles that govern the behavior of operating systems. Many issues regarding the structure of operating systems, including the problems of managing processes, processors, and memory, are examined. Various aspects of operating systems are also discussed, from input-output and files to security, protection, reliability, design methods, performance evaluation, and implementation methods.Comprised of 10 chapters, this volume begins with an overview of what constitutes an operating system, followed by a discussion on the definition and pr

  15. Budget impact analysis of the fentanyl buccal tablet for treatment of breakthrough cancer pain

    Directory of Open Access Journals (Sweden)

    Darbà J

    2013-12-01

    Full Text Available Josep Darbà,1 Lisette Kaskens,2 Rainel Sánchez-de la Rosa31University of Barcelona, Barcelona, 2BCN Health Economics and Outcomes Research SL, Barcelona, 3Medical and HEOR Department, TEVA Pharmaceutical Industries Ltd, Madrid, SpainBackground: The purpose of this study was to assess the economic impact of the fentanyl buccal tablet for the management of breakthrough cancer pain (BTcP in Spain.Methods: A 4-year budget impact model was developed for the period 2012–2015 for patients with BTcP from the perspective of the Spanish National Health System. BTcP products included in this model were rapid-onset opioids containing fentanyl (buccal, sublingual, or nasal transmucosal. Prevalence data on cancer, BTcP, opioid use, and number of BTcP episodes were obtained from the literature. Input data on health care resources associated with opioid use and opioid-induced side effects were obtained by consulting experts in oncology from different Spanish hospitals. Resources used included drugs, medical and emergency visits, other nonpharmacologic treatments, and treatment of opioid-induced side effects. Unit costs were obtained from the literature, and a 3% discount rate was applied to costs. Based on the unit costs for drugs and health care resources, the annual BTcP treatment costs per patient associated with each fentanyl product were determined to estimate the overall budget impact based on the total treatment population and the percentage of drug utilization associated with each product. One-way sensitivity analyses were conducted to test the robustness of the model.Results: Patients treated with oral opioids for BTcP were estimated at 23,291 in 2012, with an increase up to 23,413 in 2015. The average annual budget savings, with an increase of fentanyl buccal tablets, fentanyl sublingual tablets, and intranasal fentanyl spray, and a decrease in oral transmucosal fentanyl citrate, was estimated at €2.6 million, which represents a 0.5% decrease in

  16. Watch out for the blue circle: a breakthrough in family planning promotional strategy.

    Science.gov (United States)

    Sumarsono

    1989-07-01

    Realizing the potential of commercial marketing in changing the attitude and behavior of the target audience in the early years of the 4th 5-year development plan, the National Family Planning Program tried to develop new ventures in communicating the concept of the small family norm to the people. The condom was chosen as the 1st product to be sold through the social marketing project because male awareness about family planning was still low. Based on audience research, the pricing, packaging, and branding of the product was developed. The most accepted brand name was Dua Lima because it has a neutral meaning, is easily remembered, and can be described in sign language. The last reason is very important because most consumers have difficulty communicating about condoms in the sales outlet. Social marketing has proved effective because of strong public relations activities and the involvement of formal and informal leaders. This experiment has convinced family planning management that social marketing is workable for promoting the small family norm. In 1987, under the new program of self-sufficiency in family planning, the private sector is invited to participate by providing family planning services for target audiences, using the principles of self-sufficiency and self-support. There are 2 principal activities; 1) the IEC campaign, and 2) product (contraceptive) selling. IEC activities include a media campaign public relations work. Product selling is done through commercial channels such as pharmaceutical firms, drug stores, private doctors, and midwives. It was decided that the campaign would be aided by a name and logo. The blue circle was chosen because it is unique, communicative, and simple. The social marketing of contraceptives in Indonesia can be considered a breakthrough in communication strategy for a national development program.

  17. THE ARTHRITIS AND MUSCULOSKELETAL QUALITY IMPROVEMENT PROGRAM (AMQUIP: A BREAKTHROUGH SERIES METHODOLOGY PROJECT

    Directory of Open Access Journals (Sweden)

    MASTURA I

    2008-01-01

    Full Text Available The Australian government had funded the National Primary Care Collaborative (NPCC program with funding of $14.6 million over three years. One of the pilots project was the Arthritis and Musculoskeletal Quality Improvement Program (AMQuIP.The study aims to optimize general practitioners (GPs management of patients with osteoarthritis (OA of the hip and knee by identifying gaps between their current practice and best practice. The Breakthrough Series Collaborative methodology with several Plan-Do-Study-Act (PDSA cycles was employed. Participants comprises of 12 GPs/practices from two Victorian Divisions of general Practice (one rural, one metropolitan with 10 patients per GP/practice. GPs/practices attended an orientation and three learning workshops and a videoconference. GPs/practices completed PDSA cycles between workshop and reported results at workshops. GPs/practices reported use of guidelines, change in patient management and change in practice management/systems. All recruited patients completed the SF-12v2 Health Survey and WOMAC OA Index Questionnaire twice. Follow up activities including focus groups and face-to-face interviews were held six months after the final workshop. All GPs/practices used the guidelines/key messages, introduced “new” management strategies to patients, and made positive changes to their practice management/systems. Patient reported positive changes and outcomes. By using a structured methodology and evidence-based guidelines/key messages; GPs can introduce new patient management strategies, and by identifying gaps in practice management systems, positive changes can be achieved.

  18. The effect of vapor polarity and boiling point on breakthrough for binary mixtures on respirator carbon.

    Science.gov (United States)

    Robbins, C A; Breysse, P N

    1996-08-01

    This research evaluated the effect of the polarity of a second vapor on the adsorption of a polar and a nonpolar vapor using the Wheeler model. To examine the effect of polarity, it was also necessary to observe the effect of component boiling point. The 1% breakthrough time (1% tb), kinetic adsorption capacity (W(e)), and rate constant (kv) of the Wheeler model were determined for vapor challenges on carbon beds for both p-xylene and pyrrole (referred to as test vapors) individually, and in equimolar binary mixtures with the polar and nonpolar vapors toluene, p-fluorotoluene, o-dichlorobenzene, and p-dichlorobenzene (referred to as probe vapors). Probe vapor polarity (0 to 2.5 Debye) did not systematically alter the 1% tb, W(e), or kv of the test vapors. The 1% tb and W(e) for test vapors in binary mixtures can be estimated reasonably well, using the Wheeler model, from single-vapor data (1% tb +/- 30%, W(e) +/- 20%). The test vapor 1% tb depended mainly on total vapor concentration in both single and binary systems. W(e) was proportional to test vapor fractional molar concentration (mole fraction) in mixtures. The kv for p-xylene was significantly different (p boiling point; however, these differences were apparently of limited importance in estimating 1% tb for the range of boiling points tested (111 to 180 degrees C). Although the polarity and boiling point of chemicals in the range tested are not practically important in predicting 1% tb with the Wheeler model, an effect due to probe boiling point is suggested, and tests with chemicals of more widely ranging boiling point are warranted. Since the 1% tb, and thus, respirator service life, depends mainly on total vapor concentration, these data underscore the importance of taking into account the presence of other vapors when estimating respirator service life for a vapor in a mixture.

  19. Relativistic generalization of the incentive trap of interstellar travel with application to Breakthrough Starshot

    Science.gov (United States)

    Heller, René

    2017-09-01

    As new concepts of sending interstellar spacecraft to the nearest stars are now being investigated by various research teams, crucial questions about the timing of such a vast financial and labour investment arise. If humanity could build high-speed interstellar lightsails and reach α Centauri 20 yr after launch, would it be better to wait a few years, then take advantage of further technology improvements and arrive earlier despite waiting? The risk of being overtaken by a future, faster probe has been described earlier as the incentive trap. Based on 211 yr of historical data, we find that the speed growth of artificial vehicles, from steam-driven locomotives to Voyager 1, is much faster than previously believed, about 4.72 per cent annually or a doubling every 15 yr. We derive the mathematical framework to calculate the minimum of the wait time to launch t plus travel time τ(t) and extend it into the relativistic regime. We show that the t + τ(t) minimum disappears for nearby targets. There is no use of waiting once we can reach an object within about 20 yr of travel, irrespective of the actual speed. In terms of speed, the t + τ(t) minimum for a travel to α Centauri occurs at 19.6 per cent the speed of light (c), in agreement with the 20 per cent c proposed by the Breakthrough Starshot initiative. If interstellar travel at 20 per cent c could be achieved within 45 yr from today and the kinetic energy be increased at a rate consistent with the historical record, then humans can reach the 10 most nearby stars within 100 yr from today.

  20. Breakthrough in current-in-plane tunneling measurement precision by application of multi-variable fitting algorithm

    DEFF Research Database (Denmark)

    Cagliani, Alberto; Østerberg, Frederik Westergaard; Hansen, Ole

    2017-01-01

    We present a breakthrough in micro-four-point probe (M4PP) metrology to substantially improve precision of transmission line (transfer length) type measurements by application of advanced electrode position correction. In particular, we demonstrate this methodology for the M4PP current-in-plane t......We present a breakthrough in micro-four-point probe (M4PP) metrology to substantially improve precision of transmission line (transfer length) type measurements by application of advanced electrode position correction. In particular, we demonstrate this methodology for the M4PP current......-in-plane tunneling (CIPT) technique. The CIPT method has been a crucial tool in the development of magnetic tunnel junction (MTJ) stacks suitable for magnetic random-access memories for more than a decade. On two MTJ stacks, the measurement precision of resistance-area product and tunneling magnetoresistance...

  1. Stanford test called a net breakthrough - data sent at 3,500 times the speed of broadband

    CERN Multimedia

    2003-01-01

    Researchers at a Stanford University-affiliated research center have found a way to send data across the Internet more than 3,500 times faster than the typical broadband connection. The technical breakthrough set an Internet speed record too fast to be of use with present-day computers but could open the way for scientists to share and ship massive databases around the world, according to the researchers.

  2. Closed-flow column experiments—Insights into solute transport provided by a damped oscillating breakthrough behavior

    Science.gov (United States)

    Ritschel, Thomas; Totsche, Kai Uwe

    2016-03-01

    Transport studies that employ column experiments in closed-flow mode complement classical approaches by providing new characteristic features observed in the solute breakthrough and equilibrium between liquid and solid phase. Specific to the closed-flow mode is the recirculation of the effluent to the inflow via a mixing vessel. Depending on the ratio of volumes of mixing vessel and water-filled pore space, a damped oscillating solute concentration emerges in the effluent and mixing vessel. The oscillation characteristics, e.g., frequency, amplitude, and damping, allow for the investigation of solute transport in a similar fashion as known for classical open-flow column experiments. However, the closed loop conserves substances released during transport within the system. In this way, solute and porous medium can equilibrate with respect to physicochemical conditions. With this paper, the features emerging in the breakthrough curves of saturated column experiments run in closed-flow mode and methods of evaluation are illustrated under experimental boundary conditions forcing the appearance of oscillations. We demonstrate that the effective pore water volume and the pumping rate can be determined from a conservative tracer breakthrough curve uniquely. In this way, external preconditioning of the material, e.g., drying, can be avoided. A reactive breakthrough experiment revealed a significant increase in the pore water pH value as a consequence of the closed loop. These results highlight the specific impact of the closed mass balance. Furthermore, the basis for the modeling of closed-flow experiments is given by the derivation of constitutive equations and numerical implementation, validated with the presented experiments.

  3. Reactor oscillator project - Theoretical study; operation problems; choice of the ionization chamber; Projekat reaktorskog oscilatora - Teorijska razmatranja; Problematika rada, Izbor jonizacione komore

    Energy Technology Data Exchange (ETDEWEB)

    Lolic, B; Markovic, V [Institute of Nuclear Sciences Boris Kidric, Laboratorija za fiziku reaktora, Vinca, Beograd (Serbia and Montenegro)

    1961-12-15

    Theoretical study of the reactor operator covers methods of the danger coefficient and the method based on measuring the phase angle. Operation with the reactor oscillator describes measurement of the cross section and resonance integral, measurement of the fissionable materials properties, measurement of impurities in the graphite sample. A separate chapter is devoted to the choice of the appropriate ionization chamber.

  4. Bladder volume at onset of vesicoureteral reflux is an independent risk factor for breakthrough febrile urinary tract infection.

    Science.gov (United States)

    Alexander, Siobhan E; Arlen, Angela M; Storm, Douglas W; Kieran, Kathleen; Cooper, Christopher S

    2015-04-01

    Improved identification of children with vesicoureteral reflux at risk for recurrent febrile urinary tract infection may impact management decisions. We hypothesized that reflux occurring earlier during bladder filling increases the duration of exposure of the kidneys to bacteria, and, therefore, increases the risk of pyelonephritis. Children with vesicoureteral reflux and detailed voiding cystourethrogram data were identified. Bladder volume at onset of reflux was normalized for age. Demographics, reflux grade, laterality, presence/absence of bladder-bowel dysfunction and breakthrough febrile urinary tract infections were assessed. Median followup was 24 months (IQR 12 to 52). A total of 208 girls and 47 boys were analyzed with a mean ± SD age at diagnosis of 3.1 ± 2.6 years. On univariate analysis history of febrile urinary tract infection (HR 2.17, 95% CI 1.33-2.85, p = 0.01), dilating vesicoureteral reflux (HR 1.6, 95% CI 1.05-2.42, p = 0.03) and bladder-bowel dysfunction (HR 1.66, 95% CI 0.99-2.75, p = 0.05) were associated with an increased risk of breakthrough febrile urinary tract infection. Median bladder volume at onset of reflux in children with breakthrough febrile urinary tract infection was significantly less (33.1%) than in those without infection (49.5%, p = 0.003). Reflux onset at 35% predicted bladder capacity or less was associated with a significantly increased risk of breakthrough febrile urinary tract infection on multivariate analysis (HR 1.58, 95% CI 1.05-2.38, p = 0.03). Children with early filling vesicoureteral reflux are at increased risk for breakthrough febrile urinary tract infection independent of reflux grade. Bladder volume at onset of reflux should be recorded during cystograms since it provides additional prognostic information about the risk of pyelonephritis and resolution, and may assist with counseling and clinical decision making. Copyright © 2015 American Urological Association Education and Research, Inc. Published by

  5. Evolution operator equation: Integration with algebraic and finite difference methods. Applications to physical problems in classical and quantum mechanics and quantum field theory

    Energy Technology Data Exchange (ETDEWEB)

    Dattoli, Giuseppe; Torre, Amalia [ENEA, Centro Ricerche Frascati, Rome (Italy). Dipt. Innovazione; Ottaviani, Pier Luigi [ENEA, Centro Ricerche Bologna (Italy); Vasquez, Luis [Madris, Univ. Complutense (Spain). Dept. de Matemateca Aplicado

    1997-10-01

    The finite-difference based integration method for evolution-line equations is discussed in detail and framed within the general context of the evolution operator picture. Exact analytical methods are described to solve evolution-like equations in a quite general physical context. The numerical technique based on the factorization formulae of exponential operator is then illustrated and applied to the evolution-operator in both classical and quantum framework. Finally, the general view to the finite differencing schemes is provided, displaying the wide range of applications from the classical Newton equation of motion to the quantum field theory.

  6. The Breakthrough Listen Search for Intelligent Life: the first SETI results and other future science.

    Science.gov (United States)

    Enriquez, J. Emilio; Breakthrough Listen Team

    2018-01-01

    The Breakthrough Listen (BL) Initiative is the largest campaign in human history on the search for extraterrestrial intelligence. The work presented here is the first BL search for engineered signals. This comprises a sample of 692 nearby stars within 50 pc. We used the Green Bank Telescope (GBT) to conduct observations over 1.1-1.9 GHz (L-band). Our observing strategy allows us to reject most of the detected signals as terrestrial interference. During the analysis, eleven stars show events that passed our thresholding algorithm, but detailed analysis of their properties indicates they are consistent with known examples of anthropogenic radio frequency interference. This small number of false positives and their understood properties give confidence on the techniques used for this search. We conclude that, at the time of our observations none of the observed systems host high-duty-cycle radio transmitters emitting at the observed frequencies with an EIRP of 10^13 W, readily achievable by our own civilization.We can place limits on the presence of engineered signals from putative extraterrestrial civilizations inhabiting the environs of the target stars. Our results suggest that fewer than ~0.1% of the stellar systems within 50 pc possess the type of transmitters searched in this survey. This work provides the most stringent limit on the number of low power radio transmitters around nearby stars to date. We explored several metics to compare our results to previous SETI efforts. We developed a new figure-of-merit that can encompass a wider set of parameters and can be used on future SETI experiments for a meaningful comparison.We note that the current BL state-of-the-art digital backend installed at the Green Bank Observatory is the fastest ever used for a SETI experiment by a factor of a few. Here we will describe the potential use of the BL backend by other groups on complementary science, as well as a mention the ongoing and potential collaborations focused in

  7. Correlations between plasma endothelin-1 levels and breakthrough pain in patients with cancer

    Directory of Open Access Journals (Sweden)

    Yan XB

    2015-12-01

    Full Text Available Xue-bin Yan, Tuo-chao Peng, Dong Huang Department of Anesthesiologist, The Third Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China Abstract: Endothelin-1 (ET-1 may be involved in driving pain in patients with advanced cancer. However, a few studies focus on the role of ET-1 in breakthrough pain (BP. The aim of this pivotal study was to explore the correlation between the plasma (ET-1 level and BP intensity. A total of 40 patients were enrolled in the study, and they were divided into two groups: BP group and non-BP group. Moreover, 20 healthy adults were used as the normal control group. Pain intensity was measured using visual analog scale (VAS scores of 1–10. Plasma ET-1 levels were detected by an ET radioimmunoassay kit. Subsequently, the correlation of ET-1 level with the VAS score and cancer types was analyzed by Pearson’s correlation coefficient. The plasma ET-1 level in the BP group (35.31±8.02 pg/mL was higher than that in the non-BP group (29.51±6.78 pg/mL and the normal control group (24.77±10.10 pg/mL, P<0.05. In addition, the VAS score in the BP group (7.45±0.82 was higher than that in the non-BP group (2.80±1.23, P<0.05. The plasma ET-1 level was positively correlated with the VAS score of the BP group (Pearson’s r=0.42. There was no significant correlation between the plasma ET-1 level and VAS score of the non-BP group (Pearson’s r=–0.22 or/and cancer types (P>0.05. The elevated plasma ET-1 levels were positively related to BP, and targeting ET-1 may provide a novel pain-reducing therapeutic treatment in BP. Keywords: visual analog scale, correlation, cancer types, background pain

  8. Aldosterone breakthrough in dogs with naturally occurring myxomatous mitral valve disease.

    Science.gov (United States)

    Ames, M K; Atkins, C E; Eriksson, A; Hess, A M

    2017-06-01

    Aldosterone breakthrough (ABT) is the condition in which angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers fail to effectively suppress the activity of the renin angiotensin aldosterone system. The objective of this study was to determine if ABT occurs in dogs with naturally occurring myxomatous mitral valve disease receiving an ACEI, using the urine aldosterone to creatinine ratio (UAldo:C) as a measure of renin angiotensin aldosterone system activation. This study includes 39 dogs with myxomatous mitral valve disease. A UAldo:C cut-off definition (derived from a normal population of healthy, adult, and client-owned dogs) was used to determine the prevalence of ABT in this population. Spearman analysis and univariate logistic regression were used to evaluate the relationship between UAldo:C and ABT (yes/no) and eight variables (age, serum K + concentration, serum creatinine concentration, ACEI therapy duration and ACEI dosage, furosemide therapy duration and furosemide dosage, and urine sample storage time). Finally, the UAldo:C in dogs receiving spironolactone, as part congestive heart failure (CHF) therapy, was compared to dogs with CHF that were not receiving spironolactone. The prevalence of ABT was 32% in dogs with CHF and 30% in dogs without CHF. There was no relationship between either the UAldo:C or the likelihood of ABT and the eight variables. Therapy with spironolactone lead to a significant elevation of the UAldo:C. Using the UAldo:C and a relatively stringent definition of ABT, it appears that incomplete RAAS blockade is common in dogs with MMVD receiving an ACEI. The prevalence of ABT in this canine population mirrors that reported in humans. While the mechanism of ABT is likely multifactorial and still poorly understood, the proven existence of ABT in dogs offers the potential to improve the prognosis for MMVD with the addition of a mineralocorticoid receptor blocker to current therapeutic regimens

  9. On the problem of efficacy of operative and conservative treatment in degeneration of disks of the lumbar part of the vertebral column

    International Nuclear Information System (INIS)

    Klyushkin, I.V.; Mikhajlov, M.K.

    1996-01-01

    It is shown that magnetoresonance tomography gives significant diagnostic data of the state of disk structures and circumflex anatomic formations. The patients to be operated are bound to be examined using standard diagnostic algorithm. Refs. 3, figs. 2

  10. An assessment of problems experienced with operating solar systems in Canada and the northern United States. Une evaluation des difficultes rencontrees avec les systemes solaires installes au Canada et au nord des Etats-Unis

    Energy Technology Data Exchange (ETDEWEB)

    Lorriman, D

    1978-01-01

    As part of a study examining the performance of materials and components used in solar heating systems, this report addresses the actual experience with operational systems. It intends to identify factors which tend to shorten the service life of solar components, and deals with the potential problems of various components and actual problems encountered in Canada and the USA. The first part of this report considers flat plate collectors, the dominant type of solar collector in use. Specific problems are discussed in the areas of condensation, dust and dirt; breakage, cracking, chemical degradation, and loss of transmissivity of cover plates; leakage and structural failure of glazings; corrosion, erosion, impact damage, joint/bond failure, and other problems with absorber plates; degradation, discoloration, and application deficiencies of absorber coatings; and outgassing, degradation, and instability of insulation material. The second part deals with general problems of solar systems: freezing, boiling, corrosion, and inflammability of heat transfer fluids; heat transfer fluid transport, connections, storage, and control; installation-related problems such as excess snow collection, ice dam formation, leakage, and movement of components; maintenance and repair; and other considerations including safety, standards, and aesthetics. An appendix gives a brief discussion of some problems encountered with evacuated tube collectors found at two sites. 87 refs., 75 figs., 10 tabs.

  11. Some problems raised by the operation of large nuclear turbo-generator sets. Solutions proposed for the protection of large size generators

    International Nuclear Information System (INIS)

    Chaumienne, J.-P.

    1976-01-01

    The operating requirements of nuclear power stations call for relays with ever increasing performances. This urges the development of new electronic systems while giving high importance to their reliability. So as to provide for easy application and minitoring of the relays, even when the turbo-generator unit is operating, a new cubicle design is considered which offers maximum safety and flexibility in use [fr

  12. To the problem of software development for two-sided communication system between an operator and computers in the automatic control system of elementary particle accelerators

    International Nuclear Information System (INIS)

    Asyaev, Yu.V.; Burtsev, V.L.; Makarov, V.V.; Nikitin, V.D.; Solov'ev, G.N.

    1975-01-01

    Principles, composition and basic characteristics of the software for a system of operators communication with minicomputers within the automatic accelerator control system are described. It is indicated that the external language of communication proposed in the system should meet the requirements for a provision of dialogue between the operator and the minicomputer operating in the real-time mode with an accelerator. There is a set of standard procedures allowing the operator to interact with the system in a sufficiently complete and flexible manner. These standard procedures are provided in the external operator's language in the form of a set of the control statements. The basic programs of the software system for communication are MONITOR, INTERPRETER and DRIVER programs. The MONITOR program algorithm employs the following principles - service of the input/output requests in the system is made on the relative priority basis: the maximum priority is assigned to operator's requests, the requests of the dispatcher and application programs are at a lower priority level

  13. A New TS Algorithm for Solving Low-Carbon Logistics Vehicle Routing Problem with Split Deliveries by Backpack—From a Green Operation Perspective

    Science.gov (United States)

    Fu, Zhuo; Wang, Jiangtao

    2018-01-01

    In order to promote the development of low-carbon logistics and economize logistics distribution costs, the vehicle routing problem with split deliveries by backpack is studied. With the help of the model of classical capacitated vehicle routing problem, in this study, a form of discrete split deliveries was designed in which the customer demand can be split only by backpack. A double-objective mathematical model and the corresponding adaptive tabu search (TS) algorithm were constructed for solving this problem. By embedding the adaptive penalty mechanism, and adopting the random neighborhood selection strategy and reinitialization principle, the global optimization ability of the new algorithm was enhanced. Comparisons with the results in the literature show the effectiveness of the proposed algorithm. The proposed method can save the costs of low-carbon logistics and reduce carbon emissions, which is conducive to the sustainable development of low-carbon logistics. PMID:29747469

  14. A New TS Algorithm for Solving Low-Carbon Logistics Vehicle Routing Problem with Split Deliveries by Backpack-From a Green Operation Perspective.

    Science.gov (United States)

    Xia, Yangkun; Fu, Zhuo; Tsai, Sang-Bing; Wang, Jiangtao

    2018-05-10

    In order to promote the development of low-carbon logistics and economize logistics distribution costs, the vehicle routing problem with split deliveries by backpack is studied. With the help of the model of classical capacitated vehicle routing problem, in this study, a form of discrete split deliveries was designed in which the customer demand can be split only by backpack. A double-objective mathematical model and the corresponding adaptive tabu search (TS) algorithm were constructed for solving this problem. By embedding the adaptive penalty mechanism, and adopting the random neighborhood selection strategy and reinitialization principle, the global optimization ability of the new algorithm was enhanced. Comparisons with the results in the literature show the effectiveness of the proposed algorithm. The proposed method can save the costs of low-carbon logistics and reduce carbon emissions, which is conducive to the sustainable development of low-carbon logistics.

  15. Task Analytic Models to Guide Analysis and Design: Use of the Operator Function Model to Represent Pilot-Autoflight System Mode Problems

    Science.gov (United States)

    Degani, Asaf; Mitchell, Christine M.; Chappell, Alan R.; Shafto, Mike (Technical Monitor)

    1995-01-01

    Task-analytic models structure essential information about operator interaction with complex systems, in this case pilot interaction with the autoflight system. Such models serve two purposes: (1) they allow researchers and practitioners to understand pilots' actions; and (2) they provide a compact, computational representation needed to design 'intelligent' aids, e.g., displays, assistants, and training systems. This paper demonstrates the use of the operator function model to trace the process of mode engagements while a pilot is controlling an aircraft via the, autoflight system. The operator function model is a normative and nondeterministic model of how a well-trained, well-motivated operator manages multiple concurrent activities for effective real-time control. For each function, the model links the pilot's actions with the required information. Using the operator function model, this paper describes several mode engagement scenarios. These scenarios were observed and documented during a field study that focused on mode engagements and mode transitions during normal line operations. Data including time, ATC clearances, altitude, system states, and active modes and sub-modes, engagement of modes, were recorded during sixty-six flights. Using these data, seven prototypical mode engagement scenarios were extracted. One scenario details the decision of the crew to disengage a fully automatic mode in favor of a semi-automatic mode, and the consequences of this action. Another describes a mode error involving updating aircraft speed following the engagement of a speed submode. Other scenarios detail mode confusion at various phases of the flight. This analysis uses the operator function model to identify three aspects of mode engagement: (1) the progress of pilot-aircraft-autoflight system interaction; (2) control/display information required to perform mode management activities; and (3) the potential cause(s) of mode confusion. The goal of this paper is twofold

  16. State Decision-Makers Guide for Hazardous Waste Management: Defining Hazardous Wastes, Problem Recognition, Land Use, Facility Operations, Conceptual Framework, Policy Issues, Transportation.

    Science.gov (United States)

    Corson, Alan; And Others

    Presented are key issues to be addressed by state, regional, and local governments and agencies in creating effective hazardous waste management programs. Eight chapters broadly frame the topics which state-level decision makers should consider. These chapters include: (1) definition of hazardous waste; (2) problem definition and recognition; (3)…

  17. Multiple Positive Solutions of a Nonlinear Four-Point Singular Boundary Value Problem with a p-Laplacian Operator on Time Scales

    Directory of Open Access Journals (Sweden)

    Shihuang Hong

    2009-01-01

    Full Text Available We present sufficient conditions for the existence of at least twin or triple positive solutions of a nonlinear four-point singular boundary value problem with a p-Laplacian dynamic equation on a time scale. Our results are obtained via some new multiple fixed point theorems.

  18. Sutter: Breakthrough Telescope Innovation for Asteroid Survey Missions To Start a Gold Rush In Space

    Data.gov (United States)

    National Aeronautics and Space Administration — PROBLEM: These are three primary reasons why it is important for NASA to develop better ways to locate and characterize Near Earth Objects (NEOs). First, NEOs are an...

  19. Reproducing tailing in breakthrough curves: Are statistical models equally representative and predictive?

    Science.gov (United States)

    Pedretti, Daniele; Bianchi, Marco

    2018-03-01

    Breakthrough curves (BTCs) observed during tracer tests in highly heterogeneous aquifers display strong tailing. Power laws are popular models for both the empirical fitting of these curves, and the prediction of transport using upscaling models based on best-fitted estimated parameters (e.g. the power law slope or exponent). The predictive capacity of power law based upscaling models can be however questioned due to the difficulties to link model parameters with the aquifers' physical properties. This work analyzes two aspects that can limit the use of power laws as effective predictive tools: (a) the implication of statistical subsampling, which often renders power laws undistinguishable from other heavily tailed distributions, such as the logarithmic (LOG); (b) the difficulties to reconcile fitting parameters obtained from models with different formulations, such as the presence of a late-time cutoff in the power law model. Two rigorous and systematic stochastic analyses, one based on benchmark distributions and the other on BTCs obtained from transport simulations, are considered. It is found that a power law model without cutoff (PL) results in best-fitted exponents (αPL) falling in the range of typical experimental values reported in the literature (1.5 tailing becomes heavier. Strong fluctuations occur when the number of samples is limited, due to the effects of subsampling. On the other hand, when the power law model embeds a cutoff (PLCO), the best-fitted exponent (αCO) is insensitive to the degree of tailing and to the effects of subsampling and tends to a constant αCO ≈ 1. In the PLCO model, the cutoff rate (λ) is the parameter that fully reproduces the persistence of the tailing and is shown to be inversely correlated to the LOG scale parameter (i.e. with the skewness of the distribution). The theoretical results are consistent with the fitting analysis of a tracer test performed during the MADE-5 experiment. It is shown that a simple

  20. Capacitive Sensors and Breakthrough Curves in Automated Irrigation for Water and Soil Conservation

    Science.gov (United States)

    Fahmy Hussein, Mohamed

    2016-04-01

    when such sensors are used in farmers' fields. The second procedure was Breakthrough Curve (BTC) lab-method to follow the fate of chemical composition of water draining out of Ca-saturated soil columns and Exchangeable Sodium Percent, ESP, in soil materials under saturated-flow. The work was run on five packed soil-columns under hydraulic-gradient of about 6 in fine-grained soil materials (Nile clay-sediments) wetted with five NaCl aqueous solutions (10, 25, 50, 75 and 100 mEq/l). The results revealed the removal of 40 to 80% of sodium from irrigation water after 6 to 8 pore volumes flowed out in about 12 hours with the highest removal from the most dilute solution. Rapid increase of ESP was observed when the inlet solution had moderate to high TDS whereas the dilute solution (10 mEq/l) has resulted in no soil chemical degradation. The results were extrapolated to field situation and showed that Nile clayey soil would never get sodic (ESP>15) when wetted with high quality water regardless the water application duration whereas only 1-4 year of irrigation with moderate to poor-quality water (as takes place under perennial irrigation) would result in ESP increase to 15 and much higher values. A secondary but important outcome of BTC experiments was that marginal sediments could be used in multi-column cells (6 to 8 columns) to improve water-quality through removal of Na+ ions from water, whereas anions could be removed by positively-charged resins and the cells could be recycled in a proposed prototype scheme.

  1. Experimental investigation of the impact of compound-specific dispersion and electrostatic interactions on transient transport and solute breakthrough

    Science.gov (United States)

    Muniruzzaman, Muhammad; Rolle, Massimo

    2017-02-01

    This study investigates the effects of compound-specific diffusion/dispersion and electrochemical migration on transient solute transport in saturated porous media. We conducted laboratory bench-scale experiments, under advection-dominated regimes (seepage velocity: 0.5, 5, 25 m/d), in a quasi two-dimensional flow-through setup using pulse injection of multiple tracers (both uncharged and ionic species). Extensive sampling and measurement of solutes' concentrations (˜1500 samples; >3000 measurements) were performed at the outlet of the flow-through setup, at high spatial and temporal resolution. The experimental results show that compound-specific effects and charge-induced Coulombic interactions are important not only at low velocities and/or for steady state plumes but also for transient transport under high flow velocities. Such effects can lead to a remarkably different behavior of measured breakthrough curves also at very high Péclet numbers. To quantitatively interpret the experimental results, we used four modeling approaches: classical advection-dispersion equation (ADE), continuous time random walk (CTRW), dual-domain mass transfer model (DDMT), and a multicomponent ionic dispersion model. The latter is based on the multicomponent formulation of coupled diffusive/dispersive fluxes and was used to describe and explain the electrostatic effects of charged species. Furthermore, we determined experimentally the temporal profiles of the flux-related dilution index. This metric of mixing, used in connection with the traditional solute breakthrough curves, proved to be useful to correctly distinguish between plume spreading and mixing, particularly for the cases in which the sole analysis of integrated concentration breakthrough curves may lead to erroneous interpretation of plume dilution.

  2. Clinical and Microbiological Characteristics of Breakthrough Candidemia in Allogeneic Hematopoietic Stem Cell Transplant Recipients in a Japanese Hospital

    Science.gov (United States)

    Kimura, Muneyoshi; Yamamoto, Hisashi; Asano-Mori, Yuki; Nakamura, Shigeki; Yamagoe, Satoshi; Ohno, Hideaki; Miyazaki, Yoshitsugu; Abe, Masahiro; Yuasa, Mitsuhiro; Kaji, Daisuke; Kageyama, Kosei; Nishida, Aya; Ishiwata, Kazuya; Takagi, Shinsuke; Yamamoto, Go; Uchida, Naoyuki; Izutsu, Koji; Wake, Atsushi; Taniguchi, Shuichi; Yoneyama, Akiko

    2017-01-01

    ABSTRACT Few data on breakthrough candidemia (BC), defined as candidemia that develops on administration of antifungal agents (AFAs), in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are available. The medical and microbiological records of recipients of an allo-HSCT obtained between December 2008 and December 2014 were reviewed. Of 768 allo-HSCT cases, 26 developed BC. Among the 26 causative strains, 22 strains were stored and identified by sequencing. The following species were isolated: Candida parapsilosis (9 strains), C. glabrata (4 strains), C. guilliermondii (3 strains), and other Candida species (6 strains). The AFAs being used when BC developed were micafungin (17 cases), liposomal amphotericin B (5 cases), itraconazole (2 cases), and voriconazole (2 cases). All 17 cases who developed BC during micafungin administration were administered 150 mg/day of micafungin. The susceptibilities of the causative Candida species to the administered AFAs when breakthrough occurred ranged from susceptible to resistant. Especially, 85% of the Candida species that caused BC during micafungin administration were susceptible to micafungin. Additionally, 75% of the strains were wild type for susceptibility to the administered AFAs when breakthrough occurred. Systemic steroid administration and a longer severe neutropenic phase (≥5 days) were independent risk factors for BC (P = 0.016 and P = 0.015, respectively). BC developed in allo-HSCT recipients even when they received a sufficient dose of AFA, including micafungin, to which the causative Candida species were susceptible and/or had wild-type susceptibility in vitro. Systemic steroid administration and a longer severe neutropenic phase were host-based factors associated with BC. PMID:28115352

  3. The inverse of the divergence operator on perforated domains with applications to homogenization problems for the compressible Navier–Stokes system

    Czech Academy of Sciences Publication Activity Database

    Diening, L.; Feireisl, Eduard; Lu, Y.

    2017-01-01

    Roč. 23, č. 3 (2017), s. 851-868 ISSN 1292-8119 Keywords : perforated domains * Bogovskii type operators * homogenization * compressible Navier–Stokes system Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics Impact factor: 1.540, year: 2016 https://www.esaim-cocv.org/articles/cocv/abs/2017/03/cocv160016-s/cocv160016-s.html

  4. Agricultural problems

    International Nuclear Information System (INIS)

    Bickerton, George E.

    1997-01-01

    Although there were not reasons to deplore against major activity release from any of the 110 industrial reactors authorized to operate in US, the nuclear incident that occurred at the Three Mile Island Plant in 1979 urged the public conscience toward the necessity of readiness to cope with events of this type. The personnel of the Emergency Planning Office functioning in the frame of US Department of Agriculture has already participated in around 600 intervention drillings on a federal, local or state scale to plan, test or asses radiological emergency plans or to intervene locally. These exercises allowed acquiring a significant experience in elaborating emergency plans, planning the drillings, working out scenarios and evaluation of the potential impact of accidents from the agricultural point of view. We have also taken part in different international drillings among which the most recent are INEX 1 and RADEX 94. We have found on these occasions that the agricultural problems are essential preoccupations in most of the cases no matter if the context is international, national, local or of state level. The paper poses problems specifically related to milk, fruits and vegetables, soils, meat and meat products. Finally the paper discusses issues like drilling planning, alarm and notification, sampling strategy, access authorizations for farmers, removing of contamination wastes. A number of social, political and economical relating problems are also mentioned

  5. Dynamic adsorption of CO2/N2 on cation-exchanged chabazite SSZ-13: A breakthrough analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bower, Jamey K.; Barpaga, Dushyant; Prodinger, Sebastian; Krishna, Rajamani; Schaef, Herbert T.; McGrail, Bernard P.; Derewinski, Miroslaw A.; Motkuri, Radha K.

    2018-04-17

    Alkali exchanged SSZ-13 adsorbents were investigated for their applicability in separating N2 from CO2 in flue gas streams using a dynamic breakthrough method. In contrast to IAST calculations based on equilibrium isotherms, K+ exchanged SSZ-13 was found to yield the best N2 productivity under dynamic conditions where diffusion properties play a significant role. This was attributed to the selective, partial blockage of access to the CHA cavities enhancing the separation potential in a 15/85 CO2/N2 binary gas mixture.

  6. Breakthrough of the Nordic Bronze Age: Transcultural warriorhood and a Carpathian crossroad in the 16th century BC

    DEFF Research Database (Denmark)

    Vandkilde, Helle

    2014-01-01

    The breakthrough of the Nordic Bronze Age (NBA) c. 1600 bc as a koiné within Bronze Age Europe can be historically linked to the Carpathian Basin. Nordic distinctiveness entailed an entanglement of cosmology and warriorhood, albeit represented through different media in the hotspot zone (bronze) ...... momentous creativity that drew upon Carpathian originals, contacts and a pool of Carpathian ideas, but ultimately drawing on emergent Mycenaean hegemonies in the Aegean. This provided the incentive for a cosmology-rooted resource from which the NBA could take its starting point....

  7. Effect of CH4 on the CO2 breakthrough pressure and permeability of partially saturated low-permeability sandstone in the Ordos Basin, China

    Science.gov (United States)

    Zhao, Yan; Yu, Qingchun

    2018-01-01

    The behavior of CO2 that coexists with CH4 and the effect of CH4 on the CO2 stream need to be deeply analyzed and studied, especially in the presence of water. Our previous studies investigated the breakthrough pressure and permeability of pure CO2 in five partially saturated low-permeability sandstone core samples from the Ordos Basin, and we concluded that rocks with a small pore size and low permeability show considerable sealing capacity even under unsaturated conditions. In this paper, we selected three of these samples for CO2-CH4 gas-mixture breakthrough experiments under various degrees of water saturation. The breakthrough experiments were performed by increasing the gas pressure step by step until breakthrough occurred. Then, the effluent gas mixture was collected for chromatographic partitioning analysis. The results indicate that CH4 significantly affects the breakthrough pressure and permeability of CO2. The presence of CH4 in the gas mixture increases the interfacial tension and, thus, the breakthrough pressure. Therefore, the injected gas mixture that contains the highest (lowest) mole fraction of CH4 results in the largest (smallest) breakthrough pressure. The permeability of the gas mixture is greater than that for pure CO2 because of CH4, and the effective permeability decreases with increased breakthrough pressure. Chromatographic partitioning of the effluent mixture gases indicates that CH4 breaks through ahead of CO2 as a result of its weaker solubility in water. Correlations are established between (1) the breakthrough pressure and water saturation, (2) the effective permeability and water saturation, (3) the breakthrough pressure and effective permeability, and (4) the mole fraction of CO2/CH4 in the effluent mixture gases and water saturation. These results deepen our understanding of the multi-phase flow behavior in the porous media under unsaturated conditions, which have implications for formulating emergency response plans for gas

  8. The inverse of the divergence operator on perforated domains with applications to homogenization problems for the compressible Navier–Stokes system

    Czech Academy of Sciences Publication Activity Database

    Diening, L.; Feireisl, Eduard; Lu, Y.

    2017-01-01

    Roč. 23, č. 3 (2017), s. 851-868 ISSN 1292-8119 Keywords : perforated domains * Bogovskii type operators * homogenization * compressible Navier–Stokes system Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics Impact factor: 1.540, year: 2016 https://www.esaim-cocv.org/ articles /cocv/abs/2017/03/cocv160016-s/cocv160016-s.html

  9. Islamic Education Research Problem

    Directory of Open Access Journals (Sweden)

    Abdul Muthalib

    2012-04-01

    Full Text Available This paper will discuss Islamic educational studies that is reviewing how to find, limit and define problems and problem-solving concepts. The central question of this paper is to describe how to solve the problem in Islamic educational research. A researcher or educator who has the knowledge, expertise, or special interest on education for example is usually having a sensitivity to issues relating to educational research. In the research dimension of religious education, there are three types of problems, namely: Problems foundation, structural problems and operational issues. In doing research in Islamic education someone should understand research problem, limiting and formulating the problem, how to solve the problem, other problem relating to the point of research, and research approach.

  10. Reactor operation

    CERN Document Server

    Shaw, J

    2013-01-01

    Reactor Operation covers the theoretical aspects and design information of nuclear reactors. This book is composed of nine chapters that also consider their control, calibration, and experimentation.The opening chapters present the general problems of reactor operation and the principles of reactor control and operation. The succeeding chapters deal with the instrumentation, start-up, pre-commissioning, and physical experiments of nuclear reactors. The remaining chapters are devoted to the control rod calibrations and temperature coefficient measurements in the reactor. These chapters also exp

  11. Balance Problems

    Science.gov (United States)

    ... often, it could be a sign of a balance problem. Balance problems can make you feel unsteady. You may ... related injuries, such as a hip fracture. Some balance problems are due to problems in the inner ...

  12. The Breakthrough Listen Search for Intelligent Life: A Wideband Data Recorder System for the Robert C. Byrd Green Bank Telescope

    Science.gov (United States)

    MacMahon, David H. E.; Price, Danny C.; Lebofsky, Matthew; Siemion, Andrew P. V.; Croft, Steve; DeBoer, David; Enriquez, J. Emilio; Gajjar, Vishal; Hellbourg, Gregory; Isaacson, Howard; Werthimer, Dan; Abdurashidova, Zuhra; Bloss, Marty; Brandt, Joe; Creager, Ramon; Ford, John; Lynch, Ryan S.; Maddalena, Ronald J.; McCullough, Randy; Ray, Jason; Whitehead, Mark; Woody, Dave

    2018-04-01

    The Breakthrough Listen Initiative is undertaking a comprehensive search for radio and optical signatures from extraterrestrial civilizations. An integral component of the project is the design and implementation of wide-bandwidth data recorder and signal processing systems. The capabilities of these systems, particularly at radio frequencies, directly determine survey speed; further, given a fixed observing time and spectral coverage, they determine sensitivity as well. Here, we detail the Breakthrough Listen wide-bandwidth data recording system deployed at the 100 m aperture Robert C. Byrd Green Bank Telescope. The system digitizes up to 6 GHz of bandwidth at 8 bits for both polarizations, storing the resultant 24 GB s‑1 of data to disk. This system is among the highest data rate baseband recording systems in use in radio astronomy. A future system expansion will double recording capacity, to achieve a total Nyquist bandwidth of 12 GHz in two polarizations. In this paper, we present details of the system architecture, along with salient configuration and disk-write optimizations used to achieve high-throughput data capture on commodity compute servers and consumer-class hard disk drives.

  13. Integrated care for patients with a stroke in the Netherlands: results and experiences from a national Breakthrough Collaborative Improvement project

    Directory of Open Access Journals (Sweden)

    M.M.N. Minkman

    2005-03-01

    Full Text Available Purpose: This article considers the question if measurable improvements are achieved in the quality of care in stroke services by using a Breakthrough collaborative quality improvement model. Context of case: Despite the availability of explicit criteria, evidence based guidelines, national protocols and examples of best practices; stroke care in the Netherlands did not improve substantially yet. For that reason a national collaborative started in 2002 to improve integrated stroke care in 23 self selected stroke services. Data sources: Characteristics of sites, teams, aims and changes were assessed by using a questionnaire and monthly self-reports of teams. Progress in achieving significant quality improvement has been assessed on a five point Likert scale (IHI score. Case description: The stroke services (n=23 formed multidisciplinary teams, which worked together in a collaborative based on the IHI Breakthrough Series Model. Teams received instruction in quality improvement, reviewed self reported performance data, identified bottlenecks and improvement goals, and implemented “potentially better practices” based on criteria from the Edisse study, evidence based guidelines, own ideas and expert opinion. Conclusion and discussion: Quality of care has been improved in most participating stroke services. Eighty-seven percent of the teams have improved their care significantly on at least one topic. About 34% of the teams have achieved significant improvement on all aims within the time frame of the project. The project has contributed to the further development and spread of integrated stroke care in the Netherlands.

  14. Awareness, training, exchange of information and co-operation among regulatory authorities and other law enforcement institutions. Experience and problems in Latvia

    International Nuclear Information System (INIS)

    Linde, I.; Salmins, A.

    1998-01-01

    Latvia is developing infrastructure to ensure adequate system for safety and security of radioactive and nuclear materials, radiation sources and nuclear facilities within its Radiation and Nuclear Safety legal framework. The first phase of implementation was to establish and develop further relevant legal acts, but in the same time there was a need to improve the technical capabilities for the control of goods movement across the border and the need to establish the relevant educational system. The Ministry of Environmental Protection and Regional Development (MEPRD) started to participate in this process from the early beginning when the problem of illicit trafficking was foreseen. After the technical expertise carried out by the Environmental Data Centre the first border guards and customs control points were equipped with portable measurement devices. By assistance of Nordic countries and USA this system is under constant development, but full scope conceptual analysis of entire problem is not yet finished. The need for further development of the training capabilities, as well as information sharing among all relevant institutions and awareness building for decision-makers still remains. (author)

  15. Quality improvement in depression care in the Netherlands: the Depression Breakthrough Collaborative. A quality improvement report.

    NARCIS (Netherlands)

    Franx, G.C.; Meeuwissen, J.A.; Sinnema, H.; Spijker, J.; Huyser, J.; Wensing, M.J.P.; Lange, J.

    2009-01-01

    BACKGROUND: Improving the healthcare for patients with depression is a priority health policy across the world. Roughly, two major problems can be identified in daily practice: (1) the content of care is often not completely consistent with recommendations in guidelines and (2) the organization of

  16. [Population problem, comprehension problem].

    Science.gov (United States)

    Tallon, F

    1993-08-01

    Overpopulation of developing countries in general, and Rwanda in particular, is not just their problem but a problem for developed countries as well. Rapid population growth is a key factor in the increase of poverty in sub-Saharan Africa. Population growth outstrips food production. Africa receives more and more foreign food, economic, and family planning aid each year. The Government of Rwanda encourages reduced population growth. Some people criticize it, but this criticism results in mortality and suffering. One must combat this ignorance, but attitudes change slowly. Some of these same people find the government's acceptance of family planning an invasion of their privacy. Others complain that rich countries do not have campaigns to reduce births, so why should Rwanda do so? The rate of schooling does not increase in Africa, even though the number of children in school increases, because of rapid population growth. Education is key to improvements in Africa's socioeconomic growth. Thus, Africa, is underpopulated in terms of potentiality but overpopulated in terms of reality, current conditions, and possibilities of overexploitation. Africa needs to invest in human resources. Families need to save, and to so, they must refrain from having many children. Africa should resist the temptation to waste, as rich countries do, and denounce it. Africa needs to become more independent of these countries, but structural adjustment plans, growing debt, and rapid population growth limit national independence. Food aid is a means for developed countries to dominate developing countries. Modernization through foreign aid has had some positive effects on developing countries (e.g., improved hygiene, mortality reduction), but these also sparked rapid population growth. Rwandan society is no longer traditional, but it is also not yet modern. A change in mentality to fewer births, better quality of life for living infants, better education, and less burden for women must occur

  17. A model for the value of a business, some optimization problems in its operating procedures and the valuation of its debt

    Science.gov (United States)

    1997-12-01

    In this paper we present a model for the value of a firm based on observable variables and parameters: the annual turnover, the expenses, interest rates. This value is the solution of a parabolic partial differential equation. We show how the value of the company depends on its legal status such as its liability (that is, whether it is a Limited Company or a sole trader/partnership). We give examples of how the operating procedures can be optimized (for example, whether the firm should close down, relocate etc.). Finally, we show how the model can be used to value the debt issued by the firm.

  18. The Use of CK-LOG Formalism for Knowledge Representation and Problem Solving in OPPLAN-CONSULTANT: An Expert System for Naval Operational Planning.

    Science.gov (United States)

    1985-09-30

    further discussed in Sections 4 and 5. "=:.’. 1 ":210 NRL REPORT 8902 Notice that I have used the plural form, OBJECTS, in Fig. 2.1 to indicate that there...Washington, DC. Artificial Intelligence Center, SRI International , Menlo Park, CA, 1978. i 8. G. Gentzen, "Investigations into Logical Deduction," The...one of the form ( relatio -sm term-i term-Z) or (tuple-name term-I ... term-a) with or without the negation operator oT, and atm-exp denotes a timed

  19. Granular activated carbon adsorption of organic micro-pollutants in drinking water and treated wastewater--Aligning breakthrough curves and capacities.

    Science.gov (United States)

    Zietzschmann, Frederik; Stützer, Christian; Jekel, Martin

    2016-04-01

    Small-scale granular activated carbon (GAC) tests for the adsorption of organic micro-pollutants (OMP) were conducted with drinking water and wastewater treatment plant (WWTP) effluent. In both waters, three influent OMP concentration levels were tested. As long as the influent OMP concentrations are below certain thresholds, the relative breakthrough behavior is not impacted in the respective water. Accordingly, the GAC capacity for OMP is directly proportional to the influent OMP concentration in the corresponding water. The differences between the OMP breakthrough curves in drinking water and WWTP effluent can be attributed to the concentrations of the low molecular weight acid and neutral (LMW) organics of the waters. Presenting the relative OMP concentrations (c/c0) over the specific throughput of the LMW organics (mg LMW organics/g GAC), the OMP breakthrough curves in drinking water and WWTP effluent superimpose each other. This superimposition can be further increased if the UV absorbance at 254 nm (UV254) of the LMW organics is considered. In contrast, using the specific throughput of the dissolved organic carbon (DOC) did not suffice to obtain superimposed breakthrough curves. Thus, the LMW organics are the major water constituent impacting OMP adsorption onto GAC. The results demonstrate that knowing the influent OMP and LMW organics concentrations (and UV254) of different waters, the OMP breakthroughs and GAC capacities corresponding to any water can be applied to all other waters. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. A breakthrough in enzyme technology to fight penicillin resistance-industrial application of penicillin amidase.

    Science.gov (United States)

    Buchholz, Klaus

    2016-05-01

    Enzymatic penicillin hydrolysis by penicillin amidase (also penicillin acylase, PA) represents a Landmark: the first industrially and economically highly important process using an immobilized biocatalyst. Resistance of infective bacteria to antibiotics had become a major topic of research and industrial activities. Solutions to this problem, the antibiotics resistance of infective microorganisms, required the search for new antibiotics, but also the development of derivatives, notably penicillin derivatives, that overcame resistance. An obvious route was to hydrolyse penicillin to 6-aminopenicillanic acid (6-APA), as a first step, for the introduction via chemical synthesis of various different side chains. Hydrolysis via chemical reaction sequences was tedious requiring large amounts of toxic chemicals, and they were cost intensive. Enzymatic hydrolysis using penicillin amidase represented a much more elegant route. The basis for such a solution was the development of techniques for enzyme immobilization, a highly difficult task with respect to industrial application. Two pioneer groups started to develop solutions to this problem in the late 1960s and 1970s: that of Günter Schmidt-Kastner at Bayer AG (Germany) and that of Malcolm Lilly of Imperial College London. Here, one example of this development, that at Bayer, will be presented in more detail since it illustrates well the achievement of a solution to the problems of industrial application of enzymatic processes, notably development of an immobilization method for penicillin amidase suitable for scale up to application in industrial reactors under economic conditions. A range of bottlenecks and technical problems of large-scale application had to be overcome. Data giving an inside view of this pioneer achievement in the early phase of the new field of biocatalysis are presented. The development finally resulted in a highly innovative and commercially important enzymatic process to produce 6-APA that