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Sample records for breaks prevents loss

  1. An on-line pressurizer surveillance system design to prevent small-break loss-of-coolant accidents through power-operated relief valves using a microcomputer

    International Nuclear Information System (INIS)

    A small-break loss-of-coolant accident (LOCA) caused by a stuck-open power-operated relief valve is one of the important contributors to nuclear power plant risk. A pressurizer surveillance system was designed to use a microcomputer to prevent the malfunction of the system; the effect of this improvement has been assessed through probabilistic risk assessment. The microcomputer diagnoses the malfunction of the system by a process-checking method and automatically performs the backup action related to each malfunction. This improvement means that we can correctly diagnose ''spurious opening,'' ''failure to reclose,'' and ''small-break LOCA,'' which are difficult for operators to diagnose quickly and correctly, and by taking automatic backup action one can reduce the probability of human error

  2. Noise and Hearing Loss Prevention

    Science.gov (United States)

    ... Follow us on Twitter Noise Manufacturing Construction SafeInSound Noise and Hearing Loss on the NIOSH Science Blog ... Topics Publications and Products Programs Contact NIOSH NIOSH NOISE AND HEARING LOSS PREVENTION Recommend on Facebook Tweet ...

  3. Break spectrum analyses for small break loss of coolant accidents in a RESAR-3S Plant

    International Nuclear Information System (INIS)

    A series of thermal-hydraulic analyses were performed to investigate phenomena occurring during small break loss-of-coolant-accident (LOCA) sequences in a RESAR-3S pressurized water reactor. The analysis included simulations of plant behavior using the TRAC-PF1 and RELAP5/MOD2 computer codes. Series of calculations were performed using both codes for different break sizes. The analyses presented here also served an audit function in that the results shown here were used by the US Nuclear Regulatory Commission (NRC) as an independent confirmation of similar analyses performed by Westinghouse Electric Company using another computer code. 10 refs., 62 figs., 14 tabs

  4. Responses to Small Break Loss of Coolant Accidents for SMART

    International Nuclear Information System (INIS)

    The SMART NSSS adopts the design characteristics of containing most of the primary circuit components, such as the reactor core, main coolant pumps (MCPs), steam generators (SGs), and N2 gas pressurizer (PZR) in a single leak-tight Reactor Pressure Vessel (RPV) with a relatively large ratio of the primary coolant inventory to the core power compared to the conventional loop-type PWR. Due to these design characteristics, the SMART can fundamentally eliminate the possibility of Large Break Loss of Coolant Accidents (LBLOCAs), improve the natural circulation capability, and assure a sufficient time to mitigate the possibility of core uncover. Also, SMART adopts inherent safety improving features and passive engineered safety systems such as the substantially large negative moderator temperature coefficients, passive residual heat removal system, emergency core cooling system, and a steel-made leak-tight Safeguard Vessel (SV) housing the RPV. This paper presents the results of the safety analyses using a MARS/SMR code for the instantaneous guillotine ruptures of the major pipelines penetrating the RPV. The analysis results, employing conservative initial/boundary conditions and assumptions, show that the safety systems of the SMART basic design adequately remove the core decay heat without causing core uncover for all the cases of the Small Break Loss of Coolant Accidents (SBLOCAs). The sensitivity study results with variable SV conditions show that the reduced SV net free volume can shorten the time for reaching the thermal and mechanical equilibrium condition between the RPV and SV. Under these boundary conditions, the primary system inventory loss can be minimized and the core remains covered for a longer period of time without any makeup of the coolant. (authors)

  5. Preventing Vision Loss in Diabetes - Summary

    Centers for Disease Control (CDC) Podcasts

    2008-04-24

    This podcast is for a professional audience and briefly discusses how to prevent vision loss in people with diabetes.  Created: 4/24/2008 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Diabetes Translation (DDT), National Diabetes Education Program (NDEP).   Date Released: 6/4/2008.

  6. Feedwater transient and small break loss of coolant accident analyses for the Bellefonte Nuclear Plant

    International Nuclear Information System (INIS)

    Specific sequences that may lead to core damage were analyzed for the Bellefonte nuclear plant as part of the US Nuclear Regulatory Commission's Severe Accident Sequence Analysis Program. The RELAP5, SCDAP, and SCDAP/RELAP5 computer codes were used in the analyses. The two main initiating events investigated were a loss of all feedwater to the steam generators and a small cold leg break loss of coolant accident. The transients of primary interest within these categories were the TMLB' and S2D sequences. Variations on systems availability were also investigated. Possible operator actions that could prevent or delay core damage were identified, and two were investigated for a small break transient. All of the transients were analyzed until either core damage began or long-term decay heat removal was established. The analyses showed that for the sequences considered the injection flow from one high-pressure injection pump was necessary and sufficient to prevent core damage in the absence of operator actions. Operator actions were able to prevent core damage in the S2D sequence; no operator actions were available to prevent core damage in the TMLB' sequence

  7. Review of LOFT [Loss-of-Fluid Test] large break experiments

    International Nuclear Information System (INIS)

    Six non-nuclear and five nuclear large break loss-of-coolant experiments were performed in the Loss-of-Fluid Test (LOFT) PWR facility at the Idaho National Engineering Laboratory. These experiments provided a large amount of data necessary for evaluation and refinement of reactor system computer codes and had major impact on the understanding of large break loss-of-coolant accidents. An overview of these nuclear large break experiments performed under NRC and OECD LOFT programs is given and the major research results are presented. 55 refs., 89 figs., 5 tabs

  8. Evaluation of the effect of break nozzle configuration in loss-of-coolant accident analysis

    International Nuclear Information System (INIS)

    The Semiscale Mod-1 test program has utilized two different break nozzle configurations in a test facility with identical initial and boundary conditions. An evaluation has been made to determine the effect these break nozzle configurations have on system thermal-hydraulic response during a 200% double-ended cold leg break loss-of-coolant accident simulation. The first nozzle had a convergent-divergent design; the second nozzle had a convergent design with an elongated constant area throat followed by a rapid expansion. Analysis of data from tests conducted with the two nozzles shows that the critical flow characteristics at the break plane were affected by the break nozzle geometry. Differences in break flow caused differences in the core inlet flow which in turn affected core heater rod thermal response. The results of this investigation show that the break flow behavior and the resulting core thermal response in the Semiscale experimental facility can be directly correlated

  9. Infertility and Perinatal Loss: When the Bough Breaks.

    Science.gov (United States)

    Bhat, Amritha; Byatt, Nancy

    2016-03-01

    Infertility and perinatal loss are common, and associated with lower quality of life, marital discord, complicated grief, major depressive disorder, anxiety disorders, and post-traumatic stress disorder. Young women, who lack social supports, have experienced recurrent pregnancy loss or a history of trauma and / or preexisting psychiatric illness are at a higher risk of experiencing psychiatric illnesses or symptoms after a perinatal loss or during infertility. It is especially important to detect, assess, and treat depression, anxiety, or other psychiatric symptoms because infertility or perinatal loss may be caused or perpetuated by such symptoms. Screening, psychoeducation, provision of resources and referrals, and an opportunity to discuss their loss and plan for future pregnancies can facilitate addressing mental health concerns that arise. Women at risk of or who are currently experiencing psychiatric symptoms should receive a comprehensive treatment plan that includes the following: (1) proactive clinical monitoring, (2) evidence-based approaches to psychotherapy, and (3) discussion of risks, benefits, and alternatives of medication treatment during preconception and pregnancy. PMID:26847216

  10. Flow distribution due to multiple loop seal venting during a small break loss of coolant accident

    International Nuclear Information System (INIS)

    Calculations of a postulated small break Loss-of-Coolant-Accident (LOCA) have been performed using the NOTRUMP computer code for a typical Combustion Engineering pressurized water reactor (PWR). Evaluation Model initial conditions and assumptions were used in the analysis to examine a 0.1016 m (4.0 in.) equivalent diameter cold leg break. The behavior of the loop seals, and their effects on the overall system hydraulics is discussed

  11. a Simplified Methodology for the Prediction of the Small Break Loss-Of Accident.

    Science.gov (United States)

    Ward, Leonard William

    1988-12-01

    This thesis describes a complete methodology which has allowed for the development of a faster than real time computer program designed to simulate a small break loss -of-coolant accident in the primary system of a pressurized water reactor. By developing an understanding of the major phenomenon governing the small break LOCA fluid response, the system model representation can be greatly simplified leading to a very fast executing transient system blowdown code. Because of the fast execution times, the CULSETS code, or Columbia University Loss-of-Coolant Accident and System Excursion Transient Simulator code, is ideal for performing parametric studies of Emergency Core Cooling system or assessing the consequences of the many operator actions performed to place the system in a long term cooling mode following a small break LOCA. While the methodology was designed with specific application to the small break loss-of-coolant accident, it can also be used to simulate loss-of-feedwater, steam line breaks, and steam generator tube rupture events. The code is easily adaptable to a personal computer and could also be modified to provide the primary and secondary system responses to supply the required inputs to a simulator for a pressurized water reactor.

  12. Sensitivity of Savannah River Plant loss of coolant accident power limit to break size and location

    International Nuclear Information System (INIS)

    Savannah River Plant reactors are low-pressure, heavy-water reactors with six external process water loops that drive the coolant into an upper plenum and then downward through the assemblies. Assembly loss-of-coolant accident power limits are currently set in these reactors to prevent Ledinegg flow instability (FI) in any assembly flow channel. This might occur due to the power-flow mismatch during the first 2 s of the transient, i.e., the flow drops faster than the power. This study determined the sensitivity of the power limit to the postulated break area and location. The transient reactor analysis code (TRAC) was used to compute steady-state and transient system flows and pressures. The FLOWTRAN code, which employs one-dimensional hydraulics and two- or three-dimensional heat transfer, used the driving pressures generated by TRAC to compute assembly thermal-hydraulic conditions. The FLOWTRAN also iterates on assembly power to determine the minimum assembly power for which the onset of nucleate boiling (ONB) is predicted. Experimental data were then used to convert from ONB to FI. The ONB criterion was recently replaced with an onset-of-significant-voiding criterion since it is a more accurate predictor of flow instability

  13. Analysis of primary loop small-break loss-of-coolant accident

    International Nuclear Information System (INIS)

    On the basis of a typical model of the primary loop small-break loss-of-coolant accident, the transient variation of the thermo hydraulics parameters at a loss-of-coolant accident are calculated by RETRAN-02 code. The physical process and the relevant measures for protection under the incident condition are analyzed. The calculation result shows that the reactor has a favorable capacity to resist the accident. (authors)

  14. Analysis of the small break loss of coolant accident in the VVER-1000/V446 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Altaha, S. Mahmoud; Mansouri, Masoud; Jahanfarnia, Gholamreza [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Nuclear Engineering

    2015-12-15

    In this paper, the analysis of a Small Break Loss of Coolant Accident (SBLOCA) in the VVER-1000/V446 nuclear power plant is presented. For a conservative analysis of the accident, the loss of power to the NPP and failure of one accumulator, and also of two emergency core cooling systems (ECCS) in loops 2 and 3 of the primary and secondary circuits are considered when SBLOCA has occurred. The RELAP5/MOD3.2 computer code has been used in performing the analyses. Two cases of accident scenarios as 25 mm and 100 mm breaks are analyzed. The results are in good agreement with those reported in the plant's FSAR. The results of liquid velocity show that in both cases, the flow of hot legs after the break is reversed, which provides the potential for reflux condensation phenomena. Furthermore, in the 25 mm break, the flow rate in the broken and intact side downcomer remains in the downward motion while in the 100 mm break, the broken and intact side flow rate changes to the reversed state alternatively.

  15. Analysis of the small break loss of coolant accident in the VVER-1000/V446 reactor

    International Nuclear Information System (INIS)

    In this paper, the analysis of a Small Break Loss of Coolant Accident (SBLOCA) in the VVER-1000/V446 nuclear power plant is presented. For a conservative analysis of the accident, the loss of power to the NPP and failure of one accumulator, and also of two emergency core cooling systems (ECCS) in loops 2 and 3 of the primary and secondary circuits are considered when SBLOCA has occurred. The RELAP5/MOD3.2 computer code has been used in performing the analyses. Two cases of accident scenarios as 25 mm and 100 mm breaks are analyzed. The results are in good agreement with those reported in the plant's FSAR. The results of liquid velocity show that in both cases, the flow of hot legs after the break is reversed, which provides the potential for reflux condensation phenomena. Furthermore, in the 25 mm break, the flow rate in the broken and intact side downcomer remains in the downward motion while in the 100 mm break, the broken and intact side flow rate changes to the reversed state alternatively.

  16. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... such as an ophthalmologist or optometrist. The exam will include a visual acuity test to determine if ... eye for early signs of disease signs that will occur long before loss of vision. A comprehensive ...

  17. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... professional, such as an ophthalmologist or optometrist. The exam will include a visual acuity test to determine ... long before loss of vision. A comprehensive eye exam through dilated pupils at least once a year ...

  18. Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats.

    Science.gov (United States)

    Kim, Jonggun; Kim, Hyung Kwan; Kim, Saehun; Imm, Ji-Young; Whang, Kwang-Youn

    2015-12-01

    Milk is known as a safe food and contains easily absorbable minerals and proteins, including whey protein, which has demonstrated antiosteoporotic effects on ovariectomized rats. This study evaluated the antiosteoporotic effect of whey protein concentrate hydrolysate (WPCH) digested with fungal protease and whey protein concentrate (WPC). Two experiments were conducted to determine (1) efficacy of WPCH and WPC and (2) dose-dependent impact of WPCH in ovariectomized rats (10 weeks old). In Experiment I, ovariectomized rats (n=45) were allotted into three dietary treatments of 10 g/kg diet of WPC, 10 g/kg diet of WPCH, and a control diet. In Experiment II, ovariectomized rats (n=60) were fed four different diets (0, 10, 20, and 40 g/kg of WPCH). In both experiments, sham-operated rats (n=15) were also fed a control diet containing the same amount of amino acids and minerals as dietary treatments. After 6 weeks, dietary WPCH prevented loss of bone, physical properties, mineral density, and mineral content, and improved breaking strength of femurs, with similar effect to WPC. The bone resorption enzyme activity (tartrate resistance acid phosphatase) in tibia epiphysis decreased in response to WPCH supplementation, while bone formation enzyme activity (alkaline phosphatase) was unaffected by ovariectomy and dietary treatment. Bone properties and strength increased as the dietary WPCH level increased (10 and 20 g/kg), but there was no difference between the 20 and 40 g/kg treatment. WPCH and WPC supplementation ameliorated bone loss induced by ovariectomy in rats. PMID:26367331

  19. Large break loss of coolant accident analysis for Kudankulam nuclear power plant

    International Nuclear Information System (INIS)

    Full text: This paper describes the thermal hydraulic analysis for large break loss of coolant accident (LOCA) for VVER-1000 reactor. VVER is water moderated water cooled 1000 MWe pressurised water reactor with four primary coolant loops. This analysis has been carried out using thermal hydraulic code RELAPS /MOD 3.2. During break in the primary circuit the coolant inventory in the system comes down, primary pressure starts decreasing, coolant circulation through the core decreases. As a result of decrease in the coolant inventory in the primary circuit there is decrease in heat removal from the core, which can lead to rise in clad surface temperature. There will be significant rise in clad temperature before emergency core cooling system is valved in. The analysis predicts thermal hydraulic conditions following large break LOCA. Thermal hydraulic parameters like pressure, temperature, and flow at different locations in the PHT are estimated during the transient. The results have been discussed and compared with the acceptance criteria

  20. Loss of feed flow, steam generator tube rupture and steam line break thermohydraulic experiments

    International Nuclear Information System (INIS)

    The Westinghouse Model Boiler No. 2 (MB-2) steam generator test model at the Engineering Test Facility in Tampa, Florida, was reinstrumented and modified for performing a series of tests simulating steam generator accident transients. The transients simulated were: loss of feed flow, steam generator tube rupture, and steam line break events. This document presents a description of (1) the model boiler and the associated test facility, (2) the tests performed, and (3) the analyses of the test results

  1. Loss of feed flow, steam generator tube rupture and steam line break thermohydraulic experiments

    Energy Technology Data Exchange (ETDEWEB)

    Mendler, O J; Takeuchi, K; Young, M Y

    1986-10-01

    The Westinghouse Model Boiler No. 2 (MB-2) steam generator test model at the Engineering Test Facility in Tampa, Florida, was reinstrumented and modified for performing a series of tests simulating steam generator accident transients. The transients simulated were: loss of feed flow, steam generator tube rupture, and steam line break events. This document presents a description of (1) the model boiler and the associated test facility, (2) the tests performed, and (3) the analyses of the test results.

  2. Analysis of a small break loss-of-coolant accident of pressurized water reactor by APROS

    Energy Technology Data Exchange (ETDEWEB)

    Al-Falahi, A. [Helsinki Univ. of Technology, Espoo (Finland); Haennine, M. [VTT Energy, Espoo (Finland); Porkholm, K. [IVO International, Ltd., Vantaa (Finland)

    1995-09-01

    The purpose of this paper is to study the capability of APROS (Advanced PROcess Simulator) code to simulate the real plant thermal-hydraulic transient of a Small Break Loss-Of-Coolant Accident (SBLOCA) of Loss-Of-Fluid Test (LOFT) facility. The LOFT is a scaled model of a Pressurized Water Reactor (PWR). This work is a part of a larger validation of the APROS thermal-hydraulic models. The results of SBLOCA transient calculated by APROS showed a reasonable agreement with the measured data.

  3. Theory and Application of Loss of Life Risk Analysis for Dam Break

    Institute of Scientific and Technical Information of China (English)

    孙月峰; 钟登华; 李明超; 李颖

    2010-01-01

    The loss of life risk evaluation model for dam break is built in this paper.By using an improved Monte Carlo method,the overtopping probability induced by concurrent flood and wind is calculated,and the Latin Hypercube Sampling is used to generate random numbers.The Graham method is used to calculate the loss of life resulting from dam failure.With Dongwushi reservoir located at Hebei Province taken as an example,the overtopping probability induced by concurrent flood and wind is calculated as 4.77×10-6.Los...

  4. 76 FR 62093 - Preventing Occupational Hearing Loss: Stakeholder Meeting

    Science.gov (United States)

    2011-10-06

    ... of Labor's Occupational Safety and Health Administration (OSHA) published in the Federal Register (FR... Occupational Safety and Health Administration Preventing Occupational Hearing Loss: Stakeholder Meeting AGENCY: Occupational Safety and Health Administration (OSHA), Labor. ACTION: Notice of public meeting.......

  5. Preventing Strength Loss of Unbleached Kraft Pulp

    Energy Technology Data Exchange (ETDEWEB)

    Martin Hubbe; Richard Venditti; John Heitmann

    2003-04-16

    Kraft pulp fibers lose inter-fiber bonding ability when they are dried during the manufacture of paper. Adverse environmental consequences of this loss include (a) limitations on the number of times that kraft fibers can be recycled, (b) reduced paper strength, sometimes making it necessary to use heavier paper or paperboard to meet product strength requirements, increasing the usage of raw materials, (c) decreased rates of paper production in cases where the fiber furnish has been over-refined in an attempt to regain inter-fiber bonding ability. The present study is the first of its type to focus on unbleached kraft fibers, which are a main ingredient of linerboard for corrugated containers. About 90 million tons of unbleached kraft fiber are used worldwide every year for this purpose.

  6. Tracking changes and preventing loss in critical tiger habitat.

    Science.gov (United States)

    Joshi, Anup R; Dinerstein, Eric; Wikramanayake, Eric; Anderson, Michael L; Olson, David; Jones, Benjamin S; Seidensticker, John; Lumpkin, Susan; Hansen, Matthew C; Sizer, Nigel C; Davis, Crystal L; Palminteri, Suzanne; Hahn, Nathan R

    2016-04-01

    The global population of wild tigers remains dangerously low at fewer than 3500 individuals. Habitat loss, along with poaching, can undermine the international target recovery of doubling the number of wild tigers by 2022. Using a new satellite-based monitoring system, we analyzed 14 years of forest loss data within the 76 landscapes (ranging from 278 to 269,983 km(2)) that have been prioritized for conservation of wild tigers. Our analysis provides an update of the status of tiger habitat and describes new applications of technology to detect precisely where forest loss is occurring in order to curb future habitat loss. Across the 76 landscapes, forest loss was far less than anticipated (79,597 ± 22,629 km(2), 7.7% of remaining habitat) over the 14-year study period (2001-2014). Habitat loss was unevenly distributed within a subset of 29 landscapes deemed most critical for doubling wild tiger populations: 19 showed little change (1.5%), whereas 10 accounted for more than 98% (57,392 ± 16,316 km(2)) of habitat loss. Habitat loss in source population sites within 76 landscapes ranged from no loss to 435 ± 124 km(2) ([Formula: see text], SD = 89, total = 1676 ± 476 km(2)). Doubling the tiger population by 2022 requires moving beyond tracking annual changes in habitat. We highlight near-real-time forest monitoring technologies that provide alerts of forest loss at relevant spatial and temporal scales to prevent further erosion. PMID:27051881

  7. Simulation of small break loss of coolant accident in pressurized water reactor (PWR)

    International Nuclear Information System (INIS)

    A major safety concern in pressurized-water-reactor (PWR) design is the loss-of-coolant accident (LOCA),in which a break in the primary coolant circuit leads to depressurization, boiling of the coolant, consequent reduced cooling of the reactor core, and , unless remedial measures are taken, overheating of the fuel rods. This concern has led to the development of several simulators for safety analysis. This study demonstrates how the passive and active safety systems in conventional and advanced PWR behave during the small break loss of Coolant Accident (SBLOCA). The consequences of SBOLOCA have been simulated using IAEA Generic pressurized Water Reactor Simulator (GPWRS) and personal Computer Transient analyzer (PCTRAN) . The results were presented and discussed. The study has confirmed the major safety advantage of passive plants versus conventional PWRs is that the passive safety systems provide long-term core cooling and decay heat removal without the need for operator actions and without reliance on active safety-related system. (Author)

  8. The Prevention of Noise Induced Hearing Loss in Children

    Directory of Open Access Journals (Sweden)

    Robert V. Harrison

    2012-01-01

    Full Text Available Increasingly, our acoustic environment is filled with amplified sound sources (e.g., MP3 players, video game stations, and sports/entertainment venues. There is serious concern and also some controversy about the risks of acoustic trauma in children. This overview provides some basic information on the physiological mechanisms that lead to noise induced hearing loss, a survey of various studies that, on balance, indicates that there is cause for concern, and finally a discussion on measures that can help to prevent noise induced hearing loss in children. This paper is designed for public health and other healthcare professions (ENT, audiologists, family doctors, and pediatricians who should understand the risks of noise induced hearing loss and its prevention.

  9. Small break loss of coolant accident analysis for the international reactor innovative and secure (IRIS)

    International Nuclear Information System (INIS)

    The pressurized light water cooled, medium power (1000 MWt) IRIS (International Reactor Innovative and Secure) has been under development for four years by an international consortium of over 21 organizations from ten countries. The plant conceptual design was completed in 2001 and the preliminary design is nearing completion. The pre-application licensing process with NRC started in October, 2002 and IRIS is one of the designs considered by US utilities as part of the ESP (Early Site Permit) process. IRIS has been primarily focused on establishing a design with innovative safety characteristics. The first line of defense in IRIS is to eliminate event initiators that could potentially lead to core damage. In IRIS, this concept is implemented through the safety by design approach, briefly discussed in this paper. Because of the safety by design approach, the number and complexity of the safety systems and required operator actions can be minimized in IRIS. The net result is a design with significantly reduced complexity and improved operability, and extensive plant simplifications to enhance construction. This paper focus is on the IRIS response to a small break loss of coolant accident (LOCA). Note that in IRIS large break LOCA events are eliminated by the use of an integral layout configuration in which the reactor vessel contains all the reactor coolant system components including the core, control rod drive mechanisms, pressurizer, steam generators, and coolant pumps. Thus the IRIS integral configuration has no large loop piping; also, no pipes with a diameter greater than 0.1 meters are part of the reactor coolant system boundary. For small break LOCAs, IRIS features an innovative mitigation approach that is based on maintaining coolant inventory rather than providing high and low pressure injection systems to provide makeup coolant to the reactor to maintain core cooling. A brief overview of the IRIS safety concept, describing the simplified engineered

  10. Thermal hydraulic analysis of aggressive secondary cooldown in a small break loss of coolant accident with a total loss of high pressure safety injection

    International Nuclear Information System (INIS)

    Recently, Probabilistic Safety Assessment (PSA) has being applied to various fields as a basic technique of Risk-Informed Applications (RIA). The present study focuses on detailed thermal hydraulic analyses for major accident sequences and success criteria to support a development of PSA model using RIA for Korea Standard Nuclear Power plant (KSNP). The primary purpose of the present study in this year is to evaluate the success cri-teria of Aggressive Secondary Cooldown (ASC) in a Small Size Loss Of Coolant Accident (SBLOCA) without HPSI and to enhance the understanding of related thermal hydraulic behavior and phenomena. An effort was made to evaluate the system success criteria and a mission time for the recovery action by an operator to prevent the core damage for that accident scenario. The accident scenario for KSNP was a 2 inch coldleg break LOCA with a total loss of High Pressure Safety Injection (HPSI) and 1/2 Low Pressure Safety Injection (LPSI) available and perform-ing ASC limited by 55.6 .deg. C/hr (100 .deg. F/hr) cooldown rate at 15 minute after reactor trip. It successively reached the LPSI condition for about 1.5hr after starting the ASC operation with the Peak Cladding Temperature (PCT) of the hottest rod below the core damage criteria of 1204.4 .deg. C (2200 .deg. F). Sensitivity studies were performed for (1) cool-ant average temperature parameters, (2) ASC operation control method, (3) operation start time, (4) 1 inch break size. The present analysis identified thermal hydraulic phenomena and parameters affecting on the behavior, which consist of coolant break flow and inventory, parameters governing secondary heat removal, ASC operation control method, and its reference temperature parameters. In the present study, more relaxed success criteria than the previous PSA for KSNP could be generated under an assumption that an operator should maintain the ade-quate ASC operation. However, it is necessary to evaluate the uncertainties arisen from the

  11. Analysis of a large break loss of coolant accident at a pressurized water reactor

    International Nuclear Information System (INIS)

    The paper presents results of a demo analysis of a large-break loss-of-coolant accident (LB LOCA) at a PWR of the Zion NPP. The event, double ended cold leg break, is analyzed using the best estimate method, which has been verified based on the results of the L2-5 test experiment performed at the LOFT facility within the OECD 'Best Estimate Methods Uncertainty and Sensitivity Evaluation' programme. The key parameter of the event analyzed, i.e. the maximum cladding temperature, is represented by one-sided upper (0,95; 0,95) tolerance limit, in accordance with the license requirement. The uncertainty analysis is performed by using the non-parametric Wilks formula at the order of one to five, as well as by using parametric statistics assuming normal distribution of the output parameter, i.e. the maximum cladding temperature. The sensitivity of the maximum cladding temperature to the uncertain input parameters is evaluated by using Spearman's rank correlation coefficient and Pearson's correlation coefficient. The results of the sensitivity analysis determine the conservative RELAP5/MOD3.3 code models and the conservative initial and boundary conditions for a LB LOCA. The application of statistical methods is made possible owing to the availability of two hundred RELAP5/MOD3.3 code calculation runs with random values of 33 uncertain input parameters. (orig.)

  12. Loss-of-coolant accident for large pipe breaks in light water reactor plants

    International Nuclear Information System (INIS)

    The importance of loss-of-coolant accidents (LOCA) and their control for nuclear reactor safety is explained. Showing the cooling circuits and emergency core cooling systems (ECCS) of both, PWR and BWR, the possible break spectrum and the general sequence of events is discussed. The governing physical phenomena for the different LOCA phases are pointed out in more detail. Special emphasis is taken on rules, regulations and failure criteria for licensing purposes. Analysis methods and codes for both, evaluation and best-estimate model are compared under deterministic and probabilistic approach, respectively. Some insight in present integral and separate effect tests demonstrates the interdependency of analysis and experiment. Results of LOCA analysis and experiments show the present state of the art. (orig.)

  13. Large-break loss-of-coolant accidents in the updated PIUS 600 advanced reactor design

    International Nuclear Information System (INIS)

    The PIUS advanced reactor is a 640-MWe pressurized water reactor concept developed by Asea Brown Boveri. A unique feature of PIUS is the absence of mechanical control and shutdown rods. Reactivity is controlled by coolant boron concentration and the temperature of the moderator coolant. Los Alamos is supporting the US Nuclear Regulatory Commission's preapplication review of the PIUS reactor. Baseline calculations of the PIUS Supplement design were performed for a large-break loss-of-coolant (LBLOCA) initiator using TRAC-PF1/MOD2. Additional sensitivity studies examined flow blockage and boron dilution events to explore the robustness of the PIUS concept for low-probability combination events following an LBLOCA

  14. Generic evaluation of small break loss-of-coolant accident behavior in Babcock and Wilcox designed 177-FA operating plants

    International Nuclear Information System (INIS)

    Slow system depressurization resulting from small break loss-of-coolant accidents (LOCAs) in the reactor coolant system have not, until recently, received detailed analytical study comparable to that devoted to large breaks. Following the TMI-2 accident, the staff had a series of meetings with Babcock and Wilcox (B and W) and the B and W licensees. The staff requested that B and W and the licensees: (1) systematically evaluate plant response for small break loss-of-coolant accidents; (2) address each of the concerns documented in the Michelson report; (3) validate the computer codes used against the TMI-2 accident; (4) extend the break spectrum analysis to very small breaks, giving special consideration to failure of pressurizer valves to close; (5) analyze degraded conditions where AFW is not available; (6) prepare design changes aimed at reducing the probability of loss-of-coolant accidents produced by the failure of a PORV to close; and (7) develop revised emergency procedures for small breaks. This report describes the review of the generic analyses performed by B and W based on the requests stated above

  15. Preventing the loss of knowledge in nuclear power plants

    International Nuclear Information System (INIS)

    Preventing the loss of nuclear knowledge has become an important concern for the atomic energy industry. A great number of nuclear workers are getting close to the retirement age and there are not enough young qualified people to replace them. It is necessary to identify the key skills to replace senior engineers, managers and experienced workers. This paper proposes a matrix for capturing the strategic nuclear knowledge obtained from plants operation in the past decades. (author)

  16. Ion manipulation device to prevent loss of ions

    Science.gov (United States)

    Tolmachev, Aleksey; Smith, Richard D; Ibrahim, Yehia M; Anderson, Gordon A; Baker, Erin M

    2015-03-03

    An ion manipulation method and device to prevent loss of ions is disclosed. The device includes a pair of surfaces. An inner array of electrodes is coupled to the surfaces. A RF voltage and a DC voltage are alternately applied to the inner array of electrodes. The applied RF voltage is alternately positive and negative so that immediately adjacent or nearest neighbor RF applied electrodes are supplied with RF signals that are approximately 180 degrees out of phase.

  17. Data Confidentiality and Loss Prevention using Virtual Private Database

    OpenAIRE

    Lakshmi, B.; K. Parish Venkata Kumar; A. Shahnaz Banu; K. Anji Reddy

    2013-01-01

    As organizations increase their adoption of database systems as the key data management technology for day-to-day operations and decision making, the security of data managed by these systems becomes crucial. Database systems become more vulnerable to security breaches even as they gain productivity and efficiency advantages. Thus data loss prevention and in particular protection of data from unauthorized accesses remain important goal of any data management system. In this respect, over the ...

  18. Phenomena identification and ranking tables for Westinghouse AP600 small break loss-of-coolant accident, main steam line break, and steam generator tube rupture scenarios

    International Nuclear Information System (INIS)

    This report revision incorporates new experimental evidence regarding AP600 behavior during small break loss-of-coolant accidents. This report documents the results of Phenomena Identification and Ranking Table (PIRT) efforts for the Westinghouse AP600 reactor. The purpose of this PIRT is to identify important phenomena so that they may be addressed in both the experimental programs and the RELAP5/MOD3 systems analysis computer code. In Revision of this report, the responses of AP600 during small break loss-of-coolant accident, main steam line break, and steam generator tube rupture accident scenarios were evaluated by a committee of thermal-hydraulic experts. Committee membership included Idaho National Engineering and Environmental Laboratory staff and recognized thermal-hydraulic experts from outside of the laboratory. Each of the accident scenarios was subdivided into separate, sequential periods or phases. Within each phase, the plant behavior is controlled by, at most, a few thermal-hydraulic processes. The committee identified the phenomena influencing those processes, and ranked ampersand influences as being of high, medium, low, or insignificant importance. The primary product of this effort is a series of tables, one for each phase of each accident scenario, describing the thermal-hydraulic phenomena judged by the committee to be important, and the relative ranking of that importance. The rationales for the phenomena selected and their rankings are provided. This document issue incorporates an update of the small break loss-of-coolant accident portion of the report. This revision is the result of the release of experimental evidence from AP600-related integral test facilities (ROSA/AP600, OSU, and SPES) and thermal-hydraulic expert review. The activities associated with this update were performed during the period from June 1995 through November 1996. 8 refs., 26 figs., 42 tabs

  19. Phenomena identification and ranking tables for Westinghouse AP600 small break loss-of-coolant accident, main steam line break, and steam generator tube rupture scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, G.E.; Fletcher, C.D.; Davis, C.B. [and others

    1997-06-01

    This report revision incorporates new experimental evidence regarding AP600 behavior during small break loss-of-coolant accidents. This report documents the results of Phenomena Identification and Ranking Table (PIRT) efforts for the Westinghouse AP600 reactor. The purpose of this PIRT is to identify important phenomena so that they may be addressed in both the experimental programs and the RELAP5/MOD3 systems analysis computer code. In Revision of this report, the responses of AP600 during small break loss-of-coolant accident, main steam line break, and steam generator tube rupture accident scenarios were evaluated by a committee of thermal-hydraulic experts. Committee membership included Idaho National Engineering and Environmental Laboratory staff and recognized thermal-hydraulic experts from outside of the laboratory. Each of the accident scenarios was subdivided into separate, sequential periods or phases. Within each phase, the plant behavior is controlled by, at most, a few thermal-hydraulic processes. The committee identified the phenomena influencing those processes, and ranked & influences as being of high, medium, low, or insignificant importance. The primary product of this effort is a series of tables, one for each phase of each accident scenario, describing the thermal-hydraulic phenomena judged by the committee to be important, and the relative ranking of that importance. The rationales for the phenomena selected and their rankings are provided. This document issue incorporates an update of the small break loss-of-coolant accident portion of the report. This revision is the result of the release of experimental evidence from AP600-related integral test facilities (ROSA/AP600, OSU, and SPES) and thermal-hydraulic expert review. The activities associated with this update were performed during the period from June 1995 through November 1996. 8 refs., 26 figs., 42 tabs.

  20. Invited Commentary: Preventable Pregnancy Loss Is a Public Health Problem.

    Science.gov (United States)

    Hogue, Carol J

    2016-04-15

    Pregnancy loss is common and can lead to long-standing parental depression and related problems. In this issue, a study of Danish registries by Bruckner et al. (Am J Epidemiol. 2016;183(8):701-708) correlates monthly trends in unemployment with monthly trends in reported spontaneous abortion, lagged by 1 month. The observed association might be caused by a general population phenomenon, as suggested by the authors, or might represent an increased miscarriage risk only within the subset of the population that is directly affected by lost income. Preventive interventions will vary depending on which interpretation is more likely. Research into the preventability of miscarriages and stillbirths is hampered in the United States by poor-quality vital registration of these events. Investment in improved surveillance systems is needed and would be worthwhile, as illustrated by the knowledge gained about the black/white gap in infant mortality when national birth and infant death records began to be linked. In addition, institution of the Pregnancy Risk Assessment Monitoring System in 1987 shed light on the association of stressful life events with poor birth outcomes. That system can be improved by sampling women who have experienced stillbirths. Better data would facilitate not only surveillance but also hypothesis-generating epidemiologic studies for identifying preventable pregnancy loss. PMID:27009345

  1. An investigation of core liquid level depression in small break loss-of-coolant accidents

    International Nuclear Information System (INIS)

    Core liquid level depression can result in partial core dryout and heatup early in a small break loss-of-coolant accident (SBLOCA) transient. Such behavior occurs when steam, trapped in the upper regions of the reactor primary system (between the loop seal and the core inventory), moves coolant out of the core region and uncovers the rod upper elevations. The net result is core liquid level depression. Core liquid level depression and subsequent core heatups are investigated using subscale data from the ROSA-IV Program's 1/48-scale Large Scale Test Facility (LSTF) and the 1/1705-scale Semiscale facility. Both facilities are Westinghouse-type, four-loop, pressurized water reactor simulators. The depression phenomena and factors which influence the minimum core level are described and illustrated using examples from the data. Analyses of the subject experiments, conducted using the TRAC-PF1/MOD1 (Version 12.7) thermal-hydraulic code, are also described and summarized. Finally, the response of a typical Westinghouse four-loop plant (RESAR-3S) was calculated to qualitatively study coal liquid level depression in a full-scale system. 31 refs., 37 figs., 6 tabs

  2. Conjugated linoleic acid (CLA) prevents age associated skeletal muscle loss

    OpenAIRE

    Rahman, Md M.; Ganesh V. Halade; Jamali, Amina El; Fernandes, Gabriel

    2009-01-01

    In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12 months old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA or c9t11-CLA+t10c12-CLA (CLA-mix) for 6 months. Both t10c12-CLA and CLA-mix groups showed significantly higher muscle mass, as compared to CO and c9t11-CLA groups, measured by dual-energy-Xray-absorptiometry and muscle wet weight. Enhanced mitochondr...

  3. Design of a vehicle based system to prevent ozone loss

    Science.gov (United States)

    Lynn, Sean R.; Bunker, Deborah; Hesbach, Thomas D., Jr.; Howerton, Everett B.; Hreinsson, G.; Mistr, E. Kirk; Palmer, Matthew E.; Rogers, Claiborne; Tischler, Dayna S.; Wrona, Daniel J.

    1993-01-01

    Reduced quantities of ozone in the atmosphere allow greater levels of ultraviolet light (UV) radiation to reach the earth's surface. This is known to cause skin cancer and mutations. Chlorine liberated from Chlorofluorocarbons (CFC's) and natural sources initiate the destruction of stratospheric ozone through a free radical chain reaction. The project goals are to understand the processes which contribute to stratospheric ozone loss, examine ways to prevent ozone loss, and design a vehicle-based system to carry out the prevention scheme. The 1992/1993 design objectives were to accomplish the first two goals and define the requirements for an implementation vehicle to be designed in detail starting next year. Many different ozone intervention schemes have been proposed though few have been researched and none have been tested. A scheme proposed by R.J. Cicerone, Scott Elliot and R.P.Turco late in 1991 was selected because of its research support and economic feasibility. This scheme uses hydrocarbon injected into the Antarctic ozone hole to form stable compounds with free chlorine, thus reducing ozone depletion. Because most polar ozone depletion takes place during a 3-4 week period each year, the hydrocarbon must be injected during this time window. A study of the hydrocarbon injection requirements determined that 100 aircraft traveling Mach 2.4 at a maximum altitude of 66,000 ft. would provide the most economic approach to preventing ozone loss. Each aircraft would require an 8,000 nm. range and be able to carry 35,000 lbs. of propane. The propane would be stored in a three-tank high pressure system. Missions would be based from airport regions located in South America and Australia. To best provide the requirements of mission analysis, an aircraft with L/D(sub cruise) = 10.5, SFC = 0.65 (the faculty advisor suggested that this number is too low) and a 250,000 lb TOGW was selected as a baseline. Modularity and multi-role functionality were selected to be key

  4. Simulation of the SPE-4 small-break loss-of-coolant accident using RELAP5/MOD3.1

    International Nuclear Information System (INIS)

    A small-break loss-of-coolant accident (SBLOCA) experiment conducted at the PMK-2 integral test facility in Hungary is analyzed using RELAP5/MOD3.1. The experiment simulated a 7.4% break in the cold leg of a VVER-440/213-type nuclear power plant as part of the International Atomic Energy Agency's Fourth Standard Problem Exercise (SPE-4). Blind calculations of the exercise are presented, and the timing of various events throughout the transient is discussed. The measured break mass flow rate was provided to participants as part of the initial conditions and is compared to that predicted by the RELAP5 model. Preliminary test results show that RELAP5 failed to predict the rise in heater rod temperature seen in the experimental data, possibly indicating a need to renodalize the core. Once all the post-test data is provided, a more detailed analysis of the predicted data will be performed. (author)

  5. The reactor core behaviour in case of small break loss of coolant accident combined with total blackout

    International Nuclear Information System (INIS)

    After the Fukushima accident an extreme event beyond design basis is shown to be possible. The detailed analyses of an extended station blackout, where all the onsite and offsite power is failed, became very important. A large number of analyses were done in all countries operating nuclear reactors. An analysis of small break loss of coolant accident combined with total blackout is presented in this work. The operator actions in this case are very important in order to extend the time before irreversible damage to the core is done. The analysis is performed using RELAP5/Mod 3.3 for VVER‑1000 type reactor. The main conclusions are that the current emergency operating procedures are adequate to manage station blackout with small break loss of coolant accident (SBLOCA) sequence. Key words: LOCA, Safety Analyses Report, Blackout, Severe Accident

  6. Generic evaluation of feedwater transients and small break loss-of-coolant accidents in combustion engineering designed operating plants

    International Nuclear Information System (INIS)

    The purpose of this report is to summarize the results of a generic evaluation of feedwater transients, small break loss-of-coolant accidents (LOCAs), and other TMI-2-related events in the Combustion Engineering (CE)-designed operating plants and to establish or confirm the bases for their continued operation. The results of this evaluation are presented in this report in the form of a set of findings and recommendations in each of the principal review areas

  7. Nuclear safety assessment for Cernavoda NPP Unit 1 in the case of large break loss of coolant/loss of class IV power supply

    International Nuclear Information System (INIS)

    This nuclear safety analysis is performed in order to provide the results of pressure and temperature transient in containment, fission product release and dose analysis, carried out for an 80% ROH (Reactor Outlet Header) break with a total loss of Class IV electric power supply at the time of reactor trip. Containment is modelled using a four-node (room) and six-link (opening) representation of the reactor building using the PRESCON2 code. Noble gases are treated as inert species. Iodine species are modelled as liquid aerosols that are produced from the breakup of the jet from the break discharge. The analysis assumes an instantaneous self-preserving 0.1 percent conversion to organic iodine species. Aerosols are modelled by using twenty-six particle size classes in the 0.1 μ to 10,000 μ range. (author)

  8. A small reactor inter header break for Embalse nuclear power plant with loss of electrical supply

    International Nuclear Information System (INIS)

    A small reactor inlet header break was studied for Embalse Nuclear Power Station. The initial leakage rate was 55 kg/s. A low pressure trip was reached. As a consequence, electrical power supply was assumed to be lost. Results show that in 30 minutes operator actions must follow in order to avoid high fuel temperatures. (author)

  9. Childhood hearing health: educating for prevention of hearing loss.

    Science.gov (United States)

    Lacerda, Adriana Bender Moreira; Gonçalves, Claudia Giglio de Oliveira; Lacerda, Giselle; Lobato, Diolén Conceição Barros; Santos, Luciana; Moreira, Aline Carlezzo; Ribas, Angela

    2015-01-01

    Introduction The presence of noise in our society has attracted the attention of health professionals, including speech-language pathologists, who have been charged along with educators with developing hearing conservation programs in schools. Objective To describe the results of three strategies for awareness and hearing preservation in first to fourth grades in public elementary schools. Methods The level of environmental noise in classrooms was assessed, and 638 elementary school students from first to fourth grades, 5 to 10 years of age, were audiologically evaluated. After the evaluations, educational activities were presented to children and educators. Results The noise level in the classroom ranged from 71.8 to 94.8 A-weighted decibels. The environment of the classroom was found to promote sound reverberation, which hinders communication. Thirty-two students (5.1%) presented hearing alterations. Conclusion The application of strategies for a hearing conservation program at the school showed that noise is present in the room, and hearing loss, sometimes silent, affects schoolchildren. Students and teachers were aware that hearing problems can be prevented. Avoiding exposure to noise and improving the acoustics in classrooms are essential. PMID:25992146

  10. International Standard Problems and Small Break Loss-Of-Coolant Accident (SBLOCA)

    International Nuclear Information System (INIS)

    Best-estimate thermalhydraulic system codes are widely used to perform safety and licensing analyses of nuclear power plants and also used in the design of advance reactors. Evaluation of the capabilities and the performance of these codes can be accomplished by comparing the code predictions with measured experimental data obtained on different test facilities. In this respect, parallel to other national and international programs, OECD/Nea (OECD Nuclear Energy Agency) Committee on the Safety of Nuclear Installations (CSNI) has promoted, over the last twenty-nine years some forty-eight International Standard Problems (ISPs). These ISPs were performed in different fields as in-vessel thermalhydraulic behaviour, fuel behaviour under accident conditions, fission product release and transport, core/concrete interactions, hydrogen distribution and mixing, containment thermalhydraulic behaviour. 80% of these ISPs were related to the working domain of Principal Working Group no. 2 on Coolant System Behaviour (PWG2). The ISPs have been one of the major PWG2 activities for many years. The individual ISP comparison reports include the analysis and conclusions of the specific ISP exercises. A global review and synthesis on the contribution that ISPs have made to address nuclear reactor safety issues was initiated by CSNI-PWG2 and an overview on the subject of small break LOCA ISP's is given in this paper based on a report prepared by a CSNI-PWG2 writing group. In addition, the relevance of small break LOCA in a PWR with relation to nuclear reactor safety and the reorientation of the reactor safety program after TMI-2 accident, specifically small break LOCA, are shortly summarized. Five small break LOCA related ISP's are considered, since these were used for the assessment of the advanced best-estimate codes. The considered ISP's deal with the phenomenon typical of small break LOCAs in Western design PWRs. The experiments in four integral test facilities, LOBI, SPES, BETHSY

  11. Women and reproductive loss: client-worker dialogues designed to break the silence.

    Science.gov (United States)

    Price, Sarah Kye

    2008-10-01

    An estimated one in four women experiences a pregnancy loss during her lifetime. Despite the pervasiveness of fetal mortality reflected by these numbers, social workers rarely initiate dialogues regarding reproductive loss history. Reproductive loss experiences are interwoven with typical themes emerging in everyday social work practice, including mental health, self-conceptualization, social roles, and future parenting. To advance the knowledge of professional social workers regarding reproductive loss in women's lives, this article begins by synthesizing theory and empirical research related to reproductive loss and subsequent parenting. Then, four worker-initiated dialogues emerge as recommendations for integration into routine social work practice, expanding discussion of reproductive loss beyond a subset of specialized providers and into the multitude of practice settings. PMID:18853673

  12. Large break loss-of-coolant accident analysis for China Qinshan-2 nuclear power plant

    International Nuclear Information System (INIS)

    Large break LOCA analysis for China Qinshan-2 nuclear power plant has been performed using realistic evaluation model which has been being developed by KAERI. RELAP5/MOD3/KAERI code, which is a modified version of RELAP5/MOD3, is coupled with CONTEMPT4/MOD5 and is used as a best estimate code to predict the thermal hydraulic behavior of the system. PCT uncertainty which stems from code uncertainty, plant application uncertainty, scaling uncertainty and PCT bias are discussed. Among them, plant application uncertainty is described in detail. The licensing PCT is calculated by adding all the uncertainties to the best-estimate PCT. The result indicates the Qinshan-2 nuclear power plant has at least 37 deg C safety margin for large break LOCA. (Author) 10 refs., 47 figs., 14 tabs

  13. Nonlocal response in thin-film waveguides: Loss versus nonlocality and breaking of complementarity

    DEFF Research Database (Denmark)

    Raza, Søren; Christensen, Thomas; Wubs, Martijn; Bozhevolnyi, Sergey I.; Mortensen, N. Asger

    2013-01-01

    We investigate the effects of nonlocal response on the surface-plasmon polariton guiding properties of the metal-insulator (MI), metal-insulator-metal (MIM), and insulator-metal-insulator (IMI) waveguides. The nonlocal effects are described by a linearized hydrodynamic model, which includes the T...... metal. We also show that nonlocality breaks the complementarity of the MIM and IMI waveguides found in the nonretarded limit....

  14. Noise and Hearing Loss Prevention: Facts and Statistics

    Science.gov (United States)

    ... the recommended amount of exposure time. Facts and Statistics Four million workers go to work each day ... Hearing Loss DHHS (NIOSH) Publication No. 2010-136 Statistics on hearing loss in the manufacturing industry. Surveys ...

  15. International Standard Problems and Small Break Loss-of-Coolant Accident (SBLOCA

    Directory of Open Access Journals (Sweden)

    N. Aksan

    2008-01-01

    Full Text Available Best-estimate thermal-hydraulic system codes are widely used to perform safety and licensing analyses of nuclear power plants and also used in the design of advance reactors. Evaluation of the capabilities and the performance of these codes can be accomplished by comparing the code predictions with measured experimental data obtained on different test facilities. OECD/NEA Committee on the Safety of Nuclear Installations (CSNI has promoted, over the last twenty-nine years, some forty-eight international standard problems (ISPs. These ISPs were performed in different fields as in-vessel thermal-hydraulic behaviour, fuel behaviour under accident conditions, fission product release and transport, core/concrete interactions, hydrogen distribution and mixing, containment thermal-hydraulic behaviour. 80% of these ISPs were related to the working domain of principal working group no.2 on coolant system behaviour (PWG2 and were one of the major PWG2 activities for many years. A global review and synthesis on the contribution that ISPs have made to address nuclear reactor safety issues was initiated by CSNI-PWG2 and an overview on the subject of small break LOCA ISPs is given in this paper based on a report prepared by a writing group. In addition, the relevance of small break LOCA in a PWR with relation to nuclear reactor safety and the reorientation of the reactor safety program after TMI-2 accident are shortly summarized. The experiments in four integral test facilities, LOBI, SPES, BETHSY, ROSA IV/LSTF and the recorded data during a steam generator tube rupture transient in the DOEL-2 PWR (Belgium were the basis of the five small break LOCA related ISP exercises, which deal with the phenomenon typical of small break LOCAs in Western design PWRs. Some lessons learned from these small break LOCA ISPs are identified in relation to code deficiencies and capabilities, progress in the code capabilities, possibility of scaling, and various additional aspects

  16. Best estimate and uncertainty analysis of a critical large break loss of coolant accident at Darlington NGS

    International Nuclear Information System (INIS)

    This paper briefly describes the development and application of a Best Estimate Analysis with Uncertainty (BEAU) methodology to a critical large break loss of coolant accident at Darlington NGS. Best estimate and uncertainty predictions are obtained for maximum fuel centreline temperature, maximum fuel sheath temperature, maximum fuel string relative axial expansion, and peak pressure tube strain. The results are compared against similar results obtained using the Limit of Operating Envelope (LOE) approach reported in the most recent licensing submission. The comparison shows significant improvements in predicted safety margins can be achieved. (author)

  17. AP600 large-break loss-of-collant-accident developmental assessment plan for TRAC-PF1/MOD2

    International Nuclear Information System (INIS)

    The Westinghouse AP600 reactor is an advanced pressurized water reactor with passive safety systems to protect the plant against possible accidents and transients. The design has been submitted to the U.S. NRC for design certification. The NRC has selected the Transient Reactor Analysis Code (TRAC)-PF1/MOD2 for performing large break loss-of coolant-accident (LBLOCA) analysis to support the certification effort. This document defines the tests to be used in the current phase of developmental assessment related to AP600 LBLOCA

  18. Modeling operator actions during a small break loss-of-coolant accident in a Babcock and Wilcox nuclear power plant

    International Nuclear Information System (INIS)

    A small break loss-of-accident (SBLOCA) in a typical Babcock and Wilcox (B ampersand W) nuclear power plant was modeled using RELAP5/MOD3. This work was performed as part of the United States Regulatory Commission's (USNRC) Code, Scaling, Applicability and Uncertainty (CSAU) study. The break was initiated by severing one high pressure injection (HPI) line at the cold leg. Thus, the small break was further aggravated by reduced HPI flow. Comparisons between scoping runs with minimal operator action, and full operator action, clearly showed that the operator plays a key role in recovering the plant. Operator actions were modeled based on the emergency operating procedures (EOPs) and the Technical Bases Document for the EOPs. The sequence of operator actions modeled here is only one of several possibilities. Different sequences of operator actions are possible for a given accident because of the subjective decisions the operator must make when determining the status of the plant, hence, which branch of the EOP to follow. To assess the credibility of the modeled operator actions, these actions and results of the simulated accident scenario were presented to operator examiners who are familiar with B ampersand W nuclear power plants. They agreed that, in general, the modeled operator actions conform to the requirements set forth in the EOPs and are therefore plausible. This paper presents the method for modeling the operator actions and discusses the simulated accident scenario from the viewpoint of operator actions

  19. The Effects of Climate Change Perceptions on Willingness to Fund the Prevention of Wetland Loss

    OpenAIRE

    Moore, Ross G.; Daniel R. Petrolia; Kim, Tae-Goun

    2010-01-01

    Using contingent valuation, we estimate willingness to pay for prevention of wetland loss in coastal Louisiana, and indentify the factors that influence respondent choice, specifically climate change perceptions. Eighty two percent of respondents were willing to pay for some form of wetland loss prevention.

  20. Small-break loss-of-coolant accidents in the updated PIUS 600 advanced reactor design

    Energy Technology Data Exchange (ETDEWEB)

    Boyack, B.E.; Steiner, J.L.; Harmony, S.C. [Los Alamos National Lab., Albuquerque, NM (United States)] [and others

    1995-09-01

    The PIUS advanced reactor is a 640-MWe pressurized water reactor developed by Asea Brown Boveri (ABB). A unique feature of the PIUS concept is the absence of mechanical control and shutdown rods. Reactivity is normally controlled by coolant boron concentration and the temperature of the moderator coolant. ABB submitted the PIUS design to the US Nuclear Regulatory Commission (NRC) for preapplication review, and Los Alamos supported the NRC`s review effort. Baseline analyses of small-break initiators at two locations were performed with the system neutronic and thermal-hydraulic analysis code TRAC-PF1/MOD2. In addition, sensitivity studies were performed to explore the robustness of the PIUS concept to severe off-normal conditions having a very low probability of occurrence.

  1. Evaluation for small break loss of coolant accident of ATLAS facility

    International Nuclear Information System (INIS)

    ATLAS is an integral effect test facility in KAERI. Among the SBLOCA scenarios, test for the 6-inch SBLOCA was performed to identify the scaling issues of large scale test facilities. In this study, the 6-inch SBLOCA in ATLAS was evaluated by TRACEV5.0 patch3 code. The objectives of this study are to identify the prediction capability of TRACE code for the major thermal hydraulic phenomena of a SBLOCA in ATLAS. The significant results obtained from this analysis are as follows. The overall behavior of pressurizer pressure agrees well with the measured data, but it decreases slowly till the SIP injection because of the underprediction of break flow. For a SIT flow, the initial injection peak and high oscillations may result from the oscillation of interfacial heat transfer or numerical problem. The code could not predict the core water level relatively well before the loop seal clearing. (authors)

  2. Breaking boundaries for biodiversity : expanding the policy agenda to halt biodiversity loss

    OpenAIRE

    Veen, M.P.; Sanders, M.E.; Tekelenburg, A.; Gerritsen, A.L.; Lörzing, J.A.; Brink, Th.

    2010-01-01

    Our assessment from the perspective of the Netherlands, a country in the temperate zone, showed a slightly positive picture, in line with the overall results for this zone. The loss of biodiversity in the Netherlands has been slowed down, but the European target – halting the loss of biodiversity – could not be met. The picture in the Netherlands is less positive if the average low quality of the remaining Dutch biodiversity is taken into account. If the impacts on biodiversity abroad of impo...

  3. Reducing security risk using data loss prevention technology.

    Science.gov (United States)

    Beeskow, John

    2015-11-01

    Data loss/leakage protection (DLP) technology seeks to improve data security by answering three fundamental questions: > Where are confidential data stored? > Who is accessing the information? > How are data being handled? PMID:26685444

  4. Aircraft Accident Prevention: Loss-of-Control Analysis

    Science.gov (United States)

    Kwatny, Harry G.; Dongmo, Jean-Etienne T.; Chang, Bor-Chin; Bajpai, Guarav; Yasar, Murat; Belcastro, Christine M.

    2009-01-01

    The majority of fatal aircraft accidents are associated with loss-of-control . Yet the notion of loss-of-control is not well-defined in terms suitable for rigorous control systems analysis. Loss-of-control is generally associated with flight outside of the normal flight envelope, with nonlinear influences, and with an inability of the pilot to control the aircraft. The two primary sources of nonlinearity are the intrinsic nonlinear dynamics of the aircraft and the state and control constraints within which the aircraft must operate. In this paper we examine how these nonlinearities affect the ability to control the aircraft and how they may contribute to loss-of-control. Examples are provided using NASA s Generic Transport Model.

  5. Earplugs Help Prevent Hearing Loss Tied to Loud Concerts

    Science.gov (United States)

    ... hearing loss that can happen after a high-decibel music concert. While getting young people wear earplugs ... to enjoy the music, but at safer, lower decibel levels? The new study included 51 people, average ...

  6. Future Integrated Systems Concept for Preventing Aircraft Loss-of-Control Accidents

    Science.gov (United States)

    Belcastro, Christine M.; Jacobson, Steven r.

    2010-01-01

    Loss of control remains one of the largest contributors to aircraft fatal accidents worldwide. Aircraft loss-of-control accidents are highly complex in that they can result from numerous causal and contributing factors acting alone or (more often) in combination. Hence, there is no single intervention strategy to prevent these accidents. This paper presents future system concepts and research directions for preventing aircraft loss-of-control accidents.

  7. [Prevention and management of appetite loss during cancer chemotherapy].

    Science.gov (United States)

    Tsujimura, Hideki; Yamada, Mitsugi; Asako, Eri; Kodama, Yukako; Sato, Tsuneo; Nabeya, Yoshihiro

    2014-10-01

    Appetite loss during cancer chemotherapy may lead to malnutrition and a decreased quality of life. To overcome this problem, evidence-based guidelines have been established for chemotherapy-induced emesis and mucositis. However, unsolved issues such as taste alimentation remain. Since the clinical picture of appetite loss is complex, individual management strategies depending on the type of the disease and treatment are required. PMID:25335699

  8. Novel apparatus to measure hyperthermal heavy ion damage to DNA: Strand breaks, base loss, and fragmentation

    International Nuclear Information System (INIS)

    We have developed a novel apparatus that allows us to irradiate nonvolatile organic films of high mass (1-100 μg range) spread out over a large surface area (42 cm2) with low energy (kT-100 eV) heavy ions and to quantitatively analyze the film substance via standard biochemical techniques afterwards. Here we discuss the details of the apparatus and method and show that it allows us to measure substantial damage to double stranded DNA molecules (plasmids) and its fundamental subunits induced by heavy ions with unprecedented low energies, i.e., 2.5 eV/amu; these energies correspond to track end energies of stopping ions or secondary ions created along primary ion tracks. We find that hyperthermal Ar+ ions interacting with plasmid DNA will lead to the formation of single and double strand breaks, as well as fragmentation of nucleosides, which also involve chemical modifications and site specific rupture along the N1-C1 glycosidic bond, resulting in base release. In cells, such localized clustered damage will enhance the severity of DNA strand lesions, thus making them harder to repair

  9. Assessment of a large break loss of coolant accident scenario requiring operator action to initiate safety injection

    International Nuclear Information System (INIS)

    As part of the licensing basis for a nuclear power plant, the acceptability of the Emergency Core Cooling Systems (ECCS) following a postulated Loss-of-Coolant Accident (LOCA) as described in the Code of Federal Regulations (CFR), Title 10, Chapter 1, Part 50.46, must be verified. The LOCA analysis is performed with an acceptable ECCS Evaluation Model and results must show compliance with the 10 CFR 50.46 acceptance criteria. Westinghouse Electric Corporation performs Large and Small Break LOCA and LOCA-related analyses to support the licensing basis of various nuclear power plants and also performs evaluations against the licensing basis analyses as required. Occasionally, the need arises for the holder of an operating license of a nuclear power plant to submit a Licensee Event Report (LER) to the US Nuclear Regulatory Commission (USNRC) for any event of the type described in the Code of Federal Regulations, Title 10, Chapter 1, Part 50.73. To support the LER, a Justification for Past Operation (JPO) may be performed to assess the safety consequences and implications of the event based on previous operating conditions. This paper describes the work performed for the Large Break LOCA to assess the impact of an event discovered by Florida Power and Light and reported in LER-94-005-02. For this event, it was determined that under certain circumstances, operator action would have been required to initiate safety injection (SI), thus challenging the acceptability of the ECCS. This event was specifically addressed for the Large Break LOCA by using an advanced thermal hydraulic analysis methodology with realistic input assumptions

  10. Break-down of Losses in High Performing Metal-Supported Solid Oxide Fuel Cells

    DEFF Research Database (Denmark)

    Kromp, Alexander; Nielsen, Jimmi; Blennow Tullmar, Peter;

    2012-01-01

    Metal supported SOFC designs offer competitive advantages such as reduced material costs and improved mechanical robustness. On the other hand, disadvantages might arise due to possible corrosion of the porous metal parts during processing and operation at high fuel utilization. In this paper we......, the ohmic and polarization losses related to the gas diffusion in the metal support, the electrooxidation in the anode functional layer and the oxygen reduction in the mixed ionic electronic conducting cathode were determined. An additional process with a rather high relaxation frequency could be...

  11. Principal causes and ways of prevention of early reproductive losses

    OpenAIRE

    Tebelev В. G.; Rogozhina I.E.

    2011-01-01

    The literature on principal causes of early abortions and ways of treatment in the first trimester was studied. Reproductive losses in the first trimester were found out to be the most active because of 5 main groups of reasons. In each group the therapeutic way of abortion was considered

  12. Principal causes and ways of prevention of early reproductive losses

    Directory of Open Access Journals (Sweden)

    Tebelev В. G.

    2011-09-01

    Full Text Available The literature on principal causes of early abortions and ways of treatment in the first trimester was studied. Reproductive losses in the first trimester were found out to be the most active because of 5 main groups of reasons. In each group the therapeutic way of abortion was considered

  13. Quantifying reactor safety margins. Pt. 6; A physically based method of estimating PWR large break loss of coolant accident PCT

    Energy Technology Data Exchange (ETDEWEB)

    Catton, I. (California Univ., Los Angeles (USA)); Duffey, R.B.; Shaw, R.A. (EG and G Idaho, Inc., Idaho Falls (USA)); Boyack, B.E. (Los Alamos National Lab., NM (USA)); Griffith, P. (Massachusetts Inst. of Tech., Cambridge (USA)); Katsma, K.R.; Wilson, G.E. (Idaho National Engineering Lab., Idaho Falls (USA)); Lellouche, G.S.; Levy, S. (Levy (S.), Inc., Campbell, CA (USA)); Rohatgi, U.S.; Wulff, W. (Brookhaven National Lab., Upton, NY (USA)); Zuber, N. (Nuclear Regulatory Commission, Washington, DC (USA))

    1990-05-01

    The Nuclear Regulatory Commission (NRC) has issued a revised Emergency Core Cooling System (ECCS) rule allowing the use of best estimate computer codes for safety analysis. To support this revised rule the NRC and its consultants and contractors have developed and demonstrated the Code Scaling, Applicability and Uncertainty (CSAU) Evaluation Methodology. This effort lead to increased understanding of the phenomena, and their relative dominance, during Large Break Loss of Coolant Accidents (LBLOCAs) in Pressurized Water Reactors (PWRs). Consequently, it became possible, as is done in this paper, to develop a method for establishing clad temperature history by using physically based arguments and engineering correlations. The results from this method are compared with similar uncertainty estimates based on large computer codes. These comparisons provide a rationale, based on physical arguments, for evaluating the large computer code based estimates of uncertainty. (orig.).

  14. Analysis of Angra-1 fuel rod during the large break loss-of-coolant accident

    International Nuclear Information System (INIS)

    The main objective of this work is to study the fuel element behavior of the Angra 1 Nuclear Reactor, during a large loss of coolant accident caused by as rupture of the cold leg. Only the blowdown phase was considered. For this study the steps discribed below were done: - analysis of the blowdown phase was performed with the computational code RELAP4/MOD5 (option EM); analysis of the hot channel during the blowdown was made using the computational code RELAP/MOD5 (option EM); analysis of the fuel element performance during the accident with the computational code FRAP-T6. The results obtained in the steps above were compared with data presented in the Angra 1 Final Safety Analysis Report. (author)

  15. Large break loss-of-coolant accident analyses for the high flux isotope reactor

    International Nuclear Information System (INIS)

    The US Department of Energy's High Flux Isotope Reactor (HFIR) was analyzed to evaluate it's response to a spectrum of loss-of-coolant accidents (LOCAs) with potential for leading to core damage. The MELCOR severe accident analysis code (version 1.7.1) was used to evaluate the overall dynamic response of HFIR. Before conducting LOCA analyses, the steady-state thermal-hydraulic parameters evaluated by MELCOR for various loop sections were verified against steady-state operating data. Thereafter, HFIR depressurization tests were simulated to evaluate the system pressure change for a given depletion in coolant inventory. Interesting and important safety-related phenomena were observed. The current analyses (which should be considered preliminary) that occur over a period from 1 to 3 seconds do not lead to core wide fuel melting. Core fluid flashing during the initial rapid depressurization does cause fuel temperature excursions due to adiabatic-like heatup. 3 refs., 4 figs

  16. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss

    OpenAIRE

    Sun, Li; Vukicevic, Slobodan; Baliram, Ramkumarie; Yang, Guozhe; Sendak, Rebecca; McPherson, John; Zhu, Ling-ling; Iqbal, Jameel; Latif, Rauf; Natrajan, Arjun; Arabi, Ario; Yamoah, Kosj; Moonga, Baljit S.; Gabet, Yankel; Davies, Terry F.

    2008-01-01

    We recently described the direct effects of thyroid-stimulating hormone (TSH) on bone and suggested that the bone loss in hyperthyroidism, hitherto attributed solely to elevated thyroid hormone levels, could at least in part arise from accompanying decrements in serum TSH. Recent studies on both mice and human subjects provide compelling evidence that thyroid hormones and TSH have the opposite effects on the skeleton. Here, we show that TSH, when injected intermittently into rodents, even at ...

  17. Energy-Efficiency Options for Insurance Loss Prevention

    Energy Technology Data Exchange (ETDEWEB)

    Mills, E. [Ernest Orlando Lawrence Berkeley National Lab., CA (United States). Environmental Energy Technologies Div.; Knoepfel, I. [Swiss Reinsurance Co., Zurich (Switzerland)

    1997-06-09

    Energy-efficiency improvements offer the insurance industry two areas of opportunity: reducing ordinary claims and avoiding greenhouse gas emissions that could precipitate natural disaster losses resulting from global climate change. We present three vehicles for taking advantage of this opportunity, including research and development, in- house energy management, and provision of key information to insurance customers and risk managers. The complementary role for renewable energy systems is also introduced.

  18. Metastasis and bone loss: Advancing treatment and prevention

    OpenAIRE

    Coleman, Robert E.; Lipton, Allan; Roodman, G. David; Guise, Theresa A.; Boyce, Brendon F.; Brufsky, Adam M.; Clézardin, Philippe; Peter I Croucher; Gralow, Julie R.; Hadji, Peyman; Holen, Ingunn; Mundy, Gregory R.; Smith, Matthew R.; Suva, Larry J.

    2010-01-01

    Tumor metastasis to the skeleton affects over 400,000 individuals in the United States annually, more than any other site of metastasis, including significant proportions of patients with breast, prostate, lung and other solid tumors. Research on the bone microenvironment and its role in metastasis suggests a complex role in tumor growth. Parallel preclinical and clinical investigations into the role of adjuvant bone-targeted agents in preventing metastasis and avoiding cancer therapy-induced...

  19. Thermal hydraulic analysis of aggressive secondary cooldown in a small break loss of coolant accident with a total loss of high pressure safety injection

    International Nuclear Information System (INIS)

    To support the development of a Probabilistic Safety Assessment (PSA) model usable in Riskinformed Applications (RIA) for Korea Standard Nuclear power Plants (KSNP), we have performed a thermal hydraulic analysis of Aggressive Secondary Cooldown (ASC) in a 2-inch Small Break Loss Of Coolant Accident (SBLOCA) with a total loss of High Pressure Safety Injection (HPSI). The present study focuses on the estimation of the success criteria of ASC, and the enhanced understanding of the detailed thermal hydraulic behavior and phenomena. The results have shown that the Reactor Coolant System (RCS) pressure can be reduced to the Low Pressure Safety Injection (LPSI) operation conditions without core damage. It was also shown that more relaxed success criteria compared to those in the previous PSA models of KSNP could be used in the new PSA model. However, it was found that the results could be affected by various parameters related with ASC operation, i.e., reference temperature for the calculation of the cooldown rate and its control method

  20. Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome

    International Nuclear Information System (INIS)

    Background: The study was done to compare the early pregnancy loss rate in women with polycystic ovarian syndrome who received or did not receive metformin in pregnancy. Study type, settings and duration: A case control interventional study carried out at Civil Hospital Karachi, Hamdard University Hospital and Private Gynaecology clinics from January 2005 to July 2008. Subjects and Methods Eighty two non diabetic patients with polycystic ovarian syndrome who became pregnant were included in the study. A questionnaire was filled for all patients that included information on basic demography and mean age, parity, weight. Fasting blood sugar and serum insulin levels were done for all these women. Only patients with raised insulin levels (more than 10 mu/l) were included in the study and all were offered to use oral metformin throughout pregnancy as 500 mg three times a day with folic acid supplements 5 mg once daily. Those who agreed to take the drug throughout pregnancy and to comply with the therapy were taken as cases, while those who did not agree to take the medicine acted as controls. Patients with other causes of recurrent pregnancy loss were excluded from the study. All pregnancies were followed using serial ultrasound examination to see any pregnancy loss in the two groups. Eighty two cases of polycystic ovaries with pregnancy were seen during the study period. All cases had raised serum insulin levels. Fifty patients agreed to take metformin through out pregnancy while, 32 cases did not agree to take metformin during pregnancy and thus acted as controls. The two groups did not differ in mean age, parity, weight and mean fasting blood sugar levels. Fasting insulin levels were high in metformin group (18.40 mu/l ) than in controls (12.53 mu/l). Missed abortion rate was significantly lower (12%) in metformin group than in controls (28%) (p<0.028). No congenital anomalies were found in both the groups on ultrasound at 16-19 weeks. Metformin treatment during

  1. Development of the PIRT for the small break loss-of-coolant accident with high pressure injection failure and sensitivity analyses for important phenomena

    International Nuclear Information System (INIS)

    By applying this statistical evaluation method, the uncertainties of evaluation results can be estimated quantitatively, and as a consequence, excessive conservatism can be reasonably removed to obtain evaluation results with enhanced reliability. The application of a statistical safety evaluation method to analysis of the 'low pressure injection by intentional depressurization of the steam generator secondary side' which is an accident management approach in the SBLOCA (Small Break Loss-Of-Coolant Accident) with HPI (High Pressure Injection) failure is being made. RELAP5/MOD3.2 is used as the analysis code. In the present study, the PIRT (Phenomena Identification and Ranking Table) was made to extract the important phenomena, and the treatments with RELAP5 of these important phenomena were investigated. Moreover, sensitivity analyses were made for the actual plant in which the parameters of the analytical model, related to the important phenomena, were changed in order to understand the influence of these phenomena on the PCT (Peak Cladding Temperature) which is evaluation parameter quantitatively. Twenty-four important phenomena were extracted in PIRT, and it was confirmed that analytical models and correlations which are able to simulate them were built into RELAP5. In the results of sensitivity analyses for the actual plant, it was understood that the influence of three times 'CCFL at the inlet of the U-tube', 'Break flow (critical flow)', and the 'Heat transfer (at exposed core)' on the PCT was especially large. Regarding these important phenomena, it is necessary to prevent the model's uncertainty distributions from being extended excessively by carrying out experiments and examining the existing experiment data closely when the distributions are made. (author)

  2. Schools of music and conservatories and hearing loss prevention.

    Science.gov (United States)

    Chesky, Kris

    2011-03-01

    Music students are not being taught that music is a sound source capable of harming hearing. Ensemble directors of public school and college bands, orchestras, and choirs, are unaware and unprepared to recognize and manage risk from excessive sound exposures. Schools of music and conservatories around the world, and the organizations that accredit them, need to embrace the idea that schools of music are best suited to facilitate change, conduct research, create and impart knowledge, institute competency, and most importantly, cultivate a culture of responsibility and accountability throughout the music discipline. By drawing attention to actions pursued at and through the College of Music at the University of North Texas, the purpose of this paper is to encourage change and to assist others in efforts to reach the best conditions for preventing irreversible hearing disorders associated with music. PMID:21288066

  3. Method to prevent recession loss of silica and silicon-containing materials in combustion gas environments

    Science.gov (United States)

    Brun, Milivoj Konstantin; Luthra, Krishan Lal

    2003-01-01

    While silicon-containing ceramics or ceramic composites are prone to material loss in combustion gas environments, this invention introduces a method to prevent or greatly reduce the thickness loss by injecting directly an effective amount, generally in the part per million level, of silicon or silicon-containing compounds into the combustion gases.

  4. 7 CFR 760.814 - Calculation of acreage for crop losses other than prevented planted.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Calculation of acreage for crop losses other than prevented planted. 760.814 Section 760.814 Agriculture Regulations of the Department of Agriculture...-2007 Crop Disaster Program § 760.814 Calculation of acreage for crop losses other than...

  5. Integral Test and Engineering Analysis of Coolant Depletion During a Large-Break Loss-of-Coolant Accident

    International Nuclear Information System (INIS)

    This study concerns the development of an integrated calculation methodology with which to continually and consistently analyze the progression of an accident from the design-basis accident phase via core uncovery to the severe accident phase. The depletion rate of reactor coolant inventory was experimentally investigated after the safety injection failure during a large-break loss-of-coolant accident utilizing the Seoul National University Integral Test Facility (SNUF), which is scaled down to 1/6.4 in length and 1/178 in area from the APR1400 [Advanced Power Reactor 1400 MW(electric)]. The experimental results showed that the core coolant inventory decreased five times faster before than after the extinction of sweepout in the reactor downcomer, which is induced by the incoming steam from the intact cold legs. The sweepout occurred on top of the spillover from the downcomer region and expedited depletion of the core coolant inventory. The test result was simulated with the MAAP4 severe accident analysis code. The calculation results of the original MAAP4 deviated from the test data in terms of coolant inventory distribution in the test vessel. After the calculation algorithm of coolant level distribution was improved by including the subroutine of pseudo pressure buildup, which accounts for the differential pressure between the core and downcomer in MAAP4, the core melt progression was delayed by hundreds of seconds, and the code prediction was in reasonable agreement with the overall behavior of the SNUF experiment

  6. Uncertainty analysis for containment response of U.S. EPR TM reactor to large break loss-of-coolant accidents

    International Nuclear Information System (INIS)

    This paper presents an uncertainty analysis applying the GOTHIC containment analysis code to simulate the first 24-hours following a large-break loss-of-coolant accident (LBLOCA) in AREVA's U.S. EPR TM plant. The uncertainty method is modeled after a study performed by the Gesellschaft fur Anlagen und Reaktorsicherheit (GRS) using data from the Heifidampf-Reaktor (HDR) Test T31.5. The analysis method incorporates an assessment of phenomenological importance, identifying the dominant contributors that influence the principle analysis metric, containment pressure. As with the GRS approach, this study employs non-parametric statistics. This analysis illustrates U.S. EPR containment response sensitivity to realistic variation in a set of important model parameters influencing containment conditions during LBLOCA. In considering a set of model uncertainty parameters, a number of GOTHIC variation calculations were performed (59 calculations) to effect a best estimate plus uncertainty result at 95/95 coverage/confidence level for the key metric, containment pressure. The results of the importance analysis showed condensation phenomena on the surface of the containment structures to be important during the passive cooling period, which occurred prior to the start of HL (hot leg) injection of SI (safety injection). In this study, hot leg injection was assumed to initiate at 1.5 hours. Condensation phenomena faded in importance after 1.5 hours due to the hot leg injection of SI suppressing steaming. Structure conduction, especially, the physical properties of concrete, retained importance throughout the transient. (authors)

  7. Radiological consequence analyses of loss of coolant accidents of various break sizes of Pressurized Heavy Water Reactor

    International Nuclear Information System (INIS)

    For any advanced technology, it is essential to ensure that the consequences associated with the accident sequences arising, if any, from the operation of the plant are as low as possible and certainly below the guidelines/limits set by the regulatory bodies. Nuclear power is no exception to this. In this paper consequences of the events arising from Loss of Coolant Accident (LOCA) sequences in Pressurized Heavy Water Reactor (PHWR), are analysed. The sequences correspond to different break sizes of LOCA followed by the operation or otherwise of Emergency Core Cooling System (ECCS). Operation or otherwise of the containment safety systems has also been considered. It has been found that there are no releases to the environment when ECCS is available. The releases, when ECCS is not available, arise from the slack and the ground. The radionuclides considered include noble gases, iodine, and cesium. The hourly meteorological parameters (wind speed, wind direction, precipitation and stability category), considered for this study, correspond to those of Kakrapar site. The consequences evaluated are the thyroid dose and the bone marrow dose received by a person located at various distances from the release point. Isodose curves are generated. From these evaluations, it has been found that the doses are very low. The complementary cumulative frequency distributions (CCFD) for thyroid and bone marrow doses have also been presented for the cases analysed. (author)

  8. Statistical analysis of fuel failures in large break loss-of-coolant accident (LBLOCA) in EPR type nuclear power plant

    International Nuclear Information System (INIS)

    Highlights: • The number of failing fuel rods in a LB-LOCA in an EPR is evaluated. • 59 scenarios are simulated with the system code APROS. • 1000 rods per scenario are simulated with the fuel performance code FRAPTRAN-GENFLO. • All the rods in the reactor are simulated in the worst scenario. • Results suggest that the regulations set by the Finnish safety authority are met. - Abstract: In this paper, the number of failing fuel rods in a large break loss-of-coolant accident (LB-LOCA) in EPR-type nuclear power plant is evaluated using statistical methods. For this purpose, a statistical fuel failure analysis procedure has been developed. The developed method utilizes the results of nonparametric statistics, the Wilks’ formula in particular, and is based on the selection and variation of parameters that are important in accident conditions. The accident scenario is simulated with the coupled fuel performance – thermal hydraulics code FRAPTRAN-GENFLO using various parameter values and thermal hydraulic and power history boundary conditions between the simulations. The number of global scenarios is 59 (given by the Wilks’ formula), and 1000 rods are simulated in each scenario. The boundary conditions are obtained from a new statistical version of the system code APROS. As a result, in the worst global scenario, 1.2% of the simulated rods failed, and it can be concluded that the Finnish safety regulations are hereby met (max. 10% of the rods allowed to fail)

  9. Breaking the Rhythm of Depression: Cognitive Behavior Therapy and Relapse Prevention for Depression

    Directory of Open Access Journals (Sweden)

    Claudi L.H. Bockting

    2010-12-01

    Full Text Available A crucial part of the treatment of depression is the prevention of relapse and recurrence. Psychological interventions, especially cognitive behavior therapy (CBT are helpful in preventing relapse and recurrence in depression. The effectivity of four types of relapse prevention cognitive behavior therapy strategies will be addressed, i.e. acute prophylactic cognitive behavior therapy, continuation cognitive behavior therapy, sequential cognitive behavior therapy and cognitive behavior therapy in partial remission.Specific ingredients of three sequential cognitive behavior therapy programs (well-being cognitive therapy, preventive cognitive therapy, and mindfulness-based cognitive therapy will be discussed as applied after remission in patients that experienced previous depressive episodes. Sequential preventive cognitive behavior therapy after acute treatment may be an attractive alternative treatment for many patients who currently use antidepressants for years and years to prevent relapse and recurrence. This is an extremely challenging issue to research thoroughly. Future studies must rule out what intervention for whom is the best protection against relapse and recurrence in depression.

  10. Analysis of similarity between small-break loss-of-coolant accident scenarios based on identification and ranking of basic phenomena

    International Nuclear Information System (INIS)

    A methodology for quantifying the overall similarity between simulated transients in nuclear power plants is proposed. Transients are compared quantitatively by using methods based on fast Fourier transform and correlation coefficient function, in which calculated time-dependent parameters which describe dominant basic phenomena are assigned appropriate weighting factors. The methodology is presented by describing its application to the comparison of a simulated 5.08 cm (2'') small-break loss-of-coolant accident to accident scenarios with different break sizes. (author)

  11. Guest Editorial: Computer-based hearing loss prevention education program for Veterans and military personnel

    Directory of Open Access Journals (Sweden)

    Robert L. Folmer, PhD

    2012-05-01

    Full Text Available According to the Veterans Benefits Administration, more than 672,000 Veterans were service-connected for hearing loss and more than 744,000 Veterans were service-connected for tinnitus as of fiscal year 2010 [1]. Hearing loss and tinnitus are the most prevalent disabilities experienced by Veterans who served during peacetime, Operation Iraqi Freedom/Operation Enduring Freedom, World War II, and the Korean war. In fiscal year 2010, the Department of Veterans Affairs (VA provided 561,212 hearing aids at an estimated cost of $196.7 million and audiological services to Veterans at a cost of $227.4 million.1 Therefore, hearing loss and tinnitus prevention should be a priority for the VA. At least one type of hearing loss—noise-induced hearing loss (NIHL—can be prevented if appropriate protective strategies are implemented.

  12. Replication independent DNA double-strand break retention may prevent genomic instability

    Directory of Open Access Journals (Sweden)

    Pornthanakasem Wichai

    2010-03-01

    Full Text Available Abstract Background Global hypomethylation and genomic instability are cardinal features of cancers. Recently, we established a method for the detection of DNA methylation levels at sites close to endogenous DNA double strand breaks (EDSBs, and found that those sites have a higher level of methylation than the rest of the genome. Interestingly, the most significant differences between EDSBs and genomes were observed when cells were cultured in the absence of serum. DNA methylation levels on each genomic location are different. Therefore, there are more replication-independent EDSBs (RIND-EDSBs located in methylated genomic regions. Moreover, methylated and unmethylated RIND-EDSBs are differentially processed. Euchromatins respond rapidly to DSBs induced by irradiation with the phosphorylation of H2AX, γ-H2AX, and these initiate the DSB repair process. During G0, most DSBs are repaired by non-homologous end-joining repair (NHEJ, mediated by at least two distinct pathways; the Ku-mediated and the ataxia telangiectasia-mutated (ATM-mediated. The ATM-mediated pathway is more precise. Here we explored how cells process methylated RIND-EDSBs and if RIND-EDSBs play a role in global hypomethylation-induced genomic instability. Results We observed a significant number of methylated RIND-EDSBs that are retained within deacetylated chromatin and free from an immediate cellular response to DSBs, the γ-H2AX. When cells were treated with tricostatin A (TSA and the histones became hyperacetylated, the amount of γ-H2AX-bound DNA increased and the retained RIND-EDSBs were rapidly repaired. When NHEJ was simultaneously inhibited in TSA-treated cells, more EDSBs were detected. Without TSA, a sporadic increase in unmethylated RIND-EDSBs could be observed when Ku-mediated NHEJ was inhibited. Finally, a remarkable increase in RIND-EDSB methylation levels was observed when cells were depleted of ATM, but not of Ku86 and RAD51. Conclusions Methylated RIND-EDSBs are

  13. Mandibular Symphyseal/Parasymphyseal Fracture with Incisor Tooth Loss: Preventing Lower Arch Constriction.

    Science.gov (United States)

    Rahpeyma, Amin; Khajehahmadi, Saeedeh; Abdollahpour, Somayeh

    2016-03-01

    Mandibular fractures are the second most common fractures of the face after the nasal bone. Mandibular symphyseal/parasymphyseal fracture comprises 15.6 to 29.3% of mandibular fractures. Tooth loss in the fracture line is a known phenomenon, but space loss has not been evaluated comprehensively in the literature. In a retrospective study, patients with mandibular symphyseal/parasymphyseal fractures, who had been treated from 2012 to 2013 in Mashhad University, Iran, Emdadi Hospital, were recalled. Patients with mandibular incisor tooth/teeth loss were included in the study. Space loss, the technique used to replace the lost tooth/teeth, upper and lower dental midline relationship, combination fracture or fractures in other facial skeleton, and type of treatment were evaluated. Of 98 patients with mandibular symphyseal/parasymphyseal fractures, 22.5% had incisor tooth/teeth loss. In this group, 73% had space loss. Only four patients had replaced the lost tooth/teeth. Dental midlines did not match each other in patients whose feature was evaluated. Open reduction and internal fixation with miniplates were used in symphyseal/parasymphyseal fractures except one. Space loss after mandibular symphyseal/parasymphyseal fracture with incisor tooth loss is a common error. The most important factor to prevent complications related to space loss following mandibular symphyseal/parasymphyseal fracture accompanying incisor tooth loss is space preservation. PMID:26889343

  14. Applicability research of RELAP5/MOD3.3 for small break loss of coolant accident of NPP with passive safety system

    International Nuclear Information System (INIS)

    The passive core cooling system is used in AP1000 to mitigate the small break loss of coolant accident (SBLOCA). The RELAP5/MOD3.3 code is generally applicable to the traditional NPP SBLOCA research, but for the passive NPP SBLOCA, its applicability will need further study and evaluation. Based on the analysis of the important phenomenon of the SBLOCA of the passive NPP, the RELAP5/MOD3.3 code was assessed and modified. In order to verify the applicability of the modified RELAP5/MOD3.3 code, the DBA-02 and NRC-05 cases of APEX-1000 which was the test facility for verifying AP1000 small break loss of coolant accident, were simulated. It shows good agreement between the results of the modified RELAP5/MOD3.3 code and experiment data. (authors)

  15. Reliability of the emergency core cooling system of the Krsko NPP in case of large-break loss of coolant accident

    International Nuclear Information System (INIS)

    Analysis of the emergency core cooling system reliability was performed for the NPP Krsko NPP with a special respect to the large-break loss-of-coolant accident. The system is divided into subsystems and then modelled using the fault tree technique. The model was analysed separately (each subsystem individually) and as a whole, considering the assumed fault criteria. In the analyses the computer codes FTAP2 and IMPORT were used. The models include human factor contributions as well. (author)

  16. Strategies for the prevention of MP3-induced hearing loss among adolescents : Expert opinions from a Delphi study

    NARCIS (Netherlands)

    Vogel, I.; Brug, J.; Ploeg, C.P.B. van der; Raat, H.

    2009-01-01

    OBJECTIVE. To identify parties involved in the prevention of MP3-induced hearing loss among adolescents and potentially effective prevention strategies and interventions. METHODS. Thirty experts in fields such as scientific research, medical practice, community health professions, education, youth w

  17. Determination of the in-containment source term for a Large-Break Loss of Coolant Accident

    International Nuclear Information System (INIS)

    This is the report of a project that focused on one of the most important design basis accidents: the Large Break Loss Of Coolant Accident (LBLOCA) (for pressurised water reactors). The first step in the calculation of the radiological consequences of this accident is the determination of the source term inside the containment. This work deals with this part of the calculation of the LBLOCA radiological consequences for which a previous benchmark (1988) has shown wide variations in the licensing practices adopted by European countries. The calculation of this source term may naturally be split in several steps (see chapter II), corresponding to several physical stages in the release of fission products: fraction of core failure, release from the damaged fuel, airborne part of the release and the release into the reactor coolant system and the sumps, chemical behaviour of iodine in the aqueous and gas phases, natural and spray removal in the containment atmosphere. A chapter is devoted to each of these topics. In addition, two other chapters deal with the basic assumptions to define the accidental sequence and the nuclides to be considered when computing doses associated with the LBLOCA. The report describes where there is agreement between the partner organisations and where there are still differences in approach. For example, there is agreement concerning the percentage of failed fuel which could be used in future licensing assessments (however this subject is still under discussion in France, a lower value is thinkable). For existing plants, AVN (Belgium) wishes to keep the initial licensing assumptions. For the release from damaged fuel, there is not complete agreement: AVN (Belgium) wishes to maintain its present approach. IPSN (France), GRS (Germany) and NNC (UK) prefer to use their own methodologies that result in slightly different values to the proposed values for a common position. There are presently no recommendations of the release of fuel particulates

  18. Prostaglandin E2 Prevents Ovariectomy-Induced Cancellous Bone Loss in Rats

    Science.gov (United States)

    Ke, Hua Zhu; Li, Mei; Jee, Webster S. S.

    1992-01-01

    The object of this study was to determine whether prostaglandin E2, (PGE2) can prevent ovariectomy induced cancellous bone loss. Thirty-five 3-month-old female Sprague-Dawley rats were divided into two groups. The rats in the first group were ovariectomized (OVX) while the others received sham operation (sham-OVX). The OVX group was further divided into three treatment groups. The daily doses for the three groups were 0,1 and 6 mg PGE2/kg for 90 days. Bone histomorphometric analyses were performed on double-fluorescent-labeled undecalcified proximal tibial metaphysis (PTM). We confirmed that OVX induces massive cancellous bone loss (-80%) and a higher bone turnover (+143%). The new findings from the present study demonstrate that bone loss due to ovarian hormone deficiency can be prevented by a low-dose (1 mg) daily administration of PGE2. Furthermore, a higher-dose (6 mg) daily administration of PGE2 not only prevents bone loss but also adds extra bone to the proximal tibial metaphyses. PGE, at the 1-mg dose level significantly increased trabecular bone area, trabecular width, trabecular node density, density of node to node, ratio of node to free end, and thus significantly decreased trabecular separation from OVX controls. At this dose level, these same parameters did not differ significantly from sham-OVX controls. However, at the 6-mg dose level PGE2, there were significant increases in trabecular bone area, trabecular width, trabecular node density, density of node to node, and ratio of node to free end, while there was significant decrease in trabecular separation from both OVX and sham-operated controls. The changes in indices of trabecular bone microanatomical structure indicated that PGE2 prevented bone loss as well as the disconnection of existing trabeculae. In summary, PGE2, administration to OVX rats decreased bone turnover and increased bone formation parameters resulting in a positive bone balance that prevented bone loss (in both lower and higher

  19. Intratympanic steroid prevents long-term spiral ganglion neuron loss in experimental meningitis

    DEFF Research Database (Denmark)

    Worsøe, Lise Lotte; Brandt, C.T.; Lund, S.P.;

    2010-01-01

    Hypothesis: Intratympanic steroid treatment prevents hearing loss and cochlear damage in a rat model of pneumococcal meningitis. Background: Sensorineural hearing loss is a long-term complication of meningitis affecting up to a third of survivors. Streptococcus pneumoniae is the bacterial species...... distortion product otoacoustic emissions showed significant hearing loss at the low frequencies in animals treated with intratympanic steroid compared with animals treated with systemic saline (p <0.05; Mann-Whitney test). However, intratympanic steroid significantly increased the number of viable neurons in...... the spiral ganglion compared with both intratympanic and systemic saline (p = 0.0082 and p = 0.0089; Mann-Whitney test). Histology revealed fibrosis of the tympanic membrane and cavity in steroid-treated animals, which plausibly caused the low-frequency hearing loss. Conclusion: Intratympanic...

  20. Alendronate and estrogen-progestin in the long-term prevention of bone loss

    DEFF Research Database (Denmark)

    Ravn, Pernille; Bidstrup, M; Wasnich, R D;

    1999-01-01

    alendronate to placebo than in those who continuously received placebo. In years 3 and 4, bone loss in participants who switched from alendronate to placebo was similar to that seen during years 1 and 2 in those who continuously received placebo. Compared with 5 mg of alendronate per day, estrogen-medroxyprogesterone...... acetate produced similar increases in bone mineral density and estradiol-norethisterone acetate produced increases that were substantially greater. CONCLUSIONS: Four years of treatment with alendronate or estrogen-progestin prevented postmenopausal bone loss. A residual effect was seen 2 years after...

  1. A simulation of the loss of fluid accident caused by a main steam line break in a turbine building

    International Nuclear Information System (INIS)

    A real main steam line transient with pipe break and turbine building pressure and temperature transient are simulated with a computer codes TEA-Ol and KONT. The obtained results are compared with the values measured during the accident at the Thermal Power Plant Drmno. The applied methodology and computer codes are able to predict the Plant behaviour during the accident (author)

  2. Loss prevention for hog farmers: Insurance, on-farm biosecurity practices, and vaccination

    OpenAIRE

    Zhang, Yue-Hua; Li, Chu-Shiu; Liu, Chwen-Chi; Chen, Kevin Z.

    2011-01-01

    Using agricultural household survey data and claim records from insurers for the year 2009, this paper analyzes hog producers' choice of means of loss prevention and identifies the relationships among biosecurity practices, vaccination, and hog insurance. By combining one probit and two structural equations, we adopt three-stage estimations on a mixed-process model to obtain the results. The findings indicate that biosecurity practices provide the basic infrastructure for operating pig farms ...

  3. Exercise Training Prevents TNF-α Induced Loss of Force in the Diaphragm of Mice

    OpenAIRE

    Mangner, Norman; Linke, Axel; Oberbach, Andreas; Kullnick, Yvonne; Gielen, Stephan; Sandri, Marcus; Hoellriegel, Robert; Matsumoto, Yasuharu; Schuler, Gerhard; Adams, Volker

    2013-01-01

    Rationale Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are elevated in congestive heart failure and are known to induce the production of reactive oxygen species as well as to deteriorate respiratory muscle function. Objectives Given the antioxidative effects of exercise training, the aim of the present study was to investigate if exercise training is capable of preventing a TNF-α induced loss of diaphragmatic force in mice and, if so, to elucidate the potential underlying ...

  4. Preventing Loss of Independence through Exercise (PLIÉ): A Pilot Clinical Trial in Older Adults with Dementia

    OpenAIRE

    Barnes, Deborah E.; Wolf Mehling; Eveline Wu; Matthew Beristianos; Kristine Yaffe; Karyn Skultety; Chesney, Margaret A.

    2015-01-01

    Background Current dementia medications have small effect sizes, many adverse effects and do not change the disease course. Therefore, it is critically important to study alternative treatment strategies. The goal of this study was to pilot-test a novel, integrative group exercise program for individuals with mild-to-moderate dementia called Preventing Loss of Independence through Exercise (PLIÉ), which focuses on training procedural memory for basic functional movements (e.g., sit-to-stand) ...

  5. Intratympanic steroid prevents long-term spiral ganglion neuron loss in experimental meningitis

    DEFF Research Database (Denmark)

    Worsøe, Lise Lotte; Brandt, C.T.; Lund, S.P.;

    2010-01-01

    distortion product otoacoustic emissions showed significant hearing loss at the low frequencies in animals treated with intratympanic steroid compared with animals treated with systemic saline (p <0.05; Mann-Whitney test). However, intratympanic steroid significantly increased the number of viable neurons in...... the spiral ganglion compared with both intratympanic and systemic saline (p = 0.0082 and p = 0.0089; Mann-Whitney test). Histology revealed fibrosis of the tympanic membrane and cavity in steroid-treated animals, which plausibly caused the low-frequency hearing loss. Conclusion: Intratympanic...... betamethasone treatment prevents long-term spiral ganglion neuron loss in experimental pneumococcal meningitis. This finding is clinically relevant in relation to postmeningitic hearing rehabilitation by cochlear implantation. However, the drug instillation in the middle ear induced local fibrosis and a...

  6. Human activity response and prevention strategies on soil and water loss in Sichuan Province

    Institute of Scientific and Technical Information of China (English)

    FANG; Yiping; CHEN; Guojie

    2003-01-01

    Ten major factors have been selected to judge the degree of disturbance from human activity and the corresponding relationship of the impact on soil and water loss in Sichuan Province. Correlation analysis has demonstrated that stock-carrying capacity, percentage of land reclamation, population density, GDP per capita, mineral modulus and percentage of forest coverage are the 6 most relevant human activity factors. The analysis on the degree of disturbance has shown that population pressure, excessive or unreasonable activities in development of resources and destructive behavior of humans are the main causes of soil and water loss. Consequently, solving the various problems in the negative activity of humans and regulating human behavior are the first tasks that should be tackled in the conservation of water and soil. In the new era, the prevention and rectification of soil and water loss are measures based on the foundation of the ecosystem, which is a kind of management strategy for sustainable development. The foundation of this method is made up of the system innovations and breakthroughs in terms of aims, philosophy, measures, and aspects of the prevention and rectification of soil and water loss, simultaneous advance from the conceptual, policy, spatial, technical and mode levels and system integration on the treatment strategies.

  7. Loss of Control Prevention and Recovery: Onboard Guidance, Control, and Systems Technologies

    Science.gov (United States)

    Belcastro, Christine M.

    2012-01-01

    Loss of control (LOC) is one of the largest contributors to fatal aircraft accidents worldwide. LOC accidents are complex in that they can result from numerous causal and contributing factors acting alone or (more often) in combination. These LOC hazards include vehicle impairment conditions, external disturbances; vehicle upset conditions, and inappropriate crew actions or responses. Hence, there is no single intervention strategy to prevent these accidents. NASA previously defined a comprehensive research and technology development approach for reducing LOC accidents and an associated integrated system concept. Onboard technologies for improved situation awareness, guidance, and control for LOC prevention and recovery are needed as part of this approach. Such systems should include: LOC hazards effects detection and mitigation; upset detection, prevention and recovery; and mitigation of combined hazards. NASA is conducting research in each of these areas. This paper provides an overview of this research, including the near-term LOC focus and associated analysis, as well as preliminary flight system architecture.

  8. Productivity Loss Related to Neglected Tropical Diseases Eligible for Preventive Chemotherapy: A Systematic Literature Review

    Science.gov (United States)

    Rijnsburger, Adriana J.; Severens, Johan L.

    2016-01-01

    Background Neglected Tropical Diseases (NTDs) not only cause health and life expectancy loss, but can also lead to economic consequences including reduced ability to work. This article describes a systematic literature review of the effect on the economic productivity of individuals affected by one of the five worldwide most prevalent NTDs: lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths (ascariasis, trichuriasis, and hookworm infection) and trachoma. These diseases are eligible to preventive chemotherapy (PCT). Methodology/Principal Findings Eleven bibliographic databases were searched using different names of all NTDs and various keywords relating to productivity. Additional references were identified through reference lists from relevant papers. Of the 5316 unique publications found in the database searches, thirteen papers were identified for lymphatic filariasis, ten for onchocerciasis, eleven for schistosomiasis, six for soil-transmitted helminths and three for trachoma. Besides the scarcity in publications reporting the degree of productivity loss, this review revealed large variation in the estimated productivity loss related to these NTDs. Conclusions It is clear that productivity is affected by NTDs, although the actual impact depends on the type and severity of the NTD as well as on the context where the disease occurs. The largest impact on productivity loss of individuals affected by one of these diseases seems to be due to blindness from onchocerciasis and severe schistosomiasis manifestations; productivity loss due to trachoma-related blindness has never been studied directly. However, productivity loss at an individual level might differ from productivity loss at a population level because of differences in the prevalence of NTDs. Variation in estimated productivity loss between and within diseases is caused by differences in research methods and setting. Publications should provide enough information to enable

  9. Generic evaluation of feedwater transients and small break loss-of-coolant accidents in GE-designed operating plants and near-term operating license applications

    International Nuclear Information System (INIS)

    The results are presented of a generic evaluation of feedwater transients, small-break loss-of-coolant accidents (LOCAs), and other TMI-2-related events for General Electric Company (GE)-designed operating plants and near-term operating license applications to confirm or establish the bases for the continued safe operation of the operating plants. The results of this evaluation are presented in this report in the form of a set of findings and recommendations in each of the principal review areas. Additional review of the accident is continuing and further information is being obtained and evaluated. Any new information will be reviewed and modifications will be made as appropriate

  10. The ANF [Advanced Nuclear Fuels Corporation]-RELAP small-break LOCA [loss-of-coolant accident] analysis for the Comanche Peak steam electric station

    International Nuclear Information System (INIS)

    The system response code RELAP/MOD2 Idaho National Engineering Laboratory cycle 36.02, with modifications developed by Advanced Nuclear Fuels Corporation (ANF), was used to perform small-break loss-of-coolant accident (SBLOCA) calculations for the Comanche Peak steam electric station (CPSES) unit 1. The ability of the ANF-RELAP code to calculate the SBLOCA system response for the four-loop pressurized water reactor is presented by discussing the overall system response, the system mass distribution, and the core response

  11. Testing the effects of a message framing intervention on intentions towards hearing loss prevention in adolescents.

    Science.gov (United States)

    de Bruijn, Gert-Jan; Spaans, Pieter; Jansen, Bastiaan; van't Riet, Jonathan

    2016-04-01

    Adolescent hearing loss is a public health problem that has eluded effective intervention. A persuasive message strategy was tested for its effectiveness on adolescents' intention to listen to music at a reduced volume. The messages manipulated both type of message frame [positive consequences of listening to music at a reduced volume (gain-framed) versus negative consequences of not listening to music at a reduced volume (loss-framed)] and type of temporal context (short-term versus long-term consequences). Participants were recruited from four vocational and secondary education schools in the Netherlands and message exposure took place online during class hours. Two weeks prior to message exposure, adolescents provided data on intention and risk perception towards hearing loss and use of (digital) music players. After message exposure, 194 adolescents (mean age = 14.71 years, SD = 1.00, 37.8% males) provided immediate follow-up data on intention. Results revealed that intention to listen to music at a reduced volume increased in those exposed to a loss-framed message with short-term consequences. No changes were found in the other conditions. Messages that emphasize negative short-term consequences of not listening to music at a moderate volume have the ability to influence adolescents' intention towards hearing loss prevention. PMID:26956040

  12. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.

    Science.gov (United States)

    Hirota, Kouji; Tsuda, Masataka; Murai, Junko; Takagi, Tokiyo; Keka, Islam Shamima; Narita, Takeo; Fujita, Mari; Sasanuma, Hiroyuki; Kobayashi, Junya; Takeda, Shunichi

    2014-10-01

    RING finger protein 4 (RNF4) represents a subclass of ubiquitin ligases that target proteins modified by the small ubiquitin-like modifier (SUMO) for ubiquitin-mediated degradation. We disrupted the RNF4 gene in chicken DT40 cells and found that the resulting RNF4(-/-) cells gradually lost proliferation capability. Strikingly, this compromised proliferation was associated with an unprecedented cellular effect: the gradual decrease in the number of intact chromosomes. In the 6 weeks after gene targeting, there was a 25% reduction in the DNA content of the RNF4(-/-) cells. Regarding trisomic chromosome 2, 60% of the RNF4(-/-) cells lost one homologue, suggesting that DNA loss was mediated by whole chromosome loss. To determine the cause of this chromosome loss, we examined cell-cycle checkpoint pathways. RNF4(-/-) cells showed a partial defect in the spindle assembly checkpoint, premature dissociation of sister chromatids, and a marked increase in the number of lagging chromosomes at anaphase. Thus, combined defects in SAC and sister chromatid cohesion may result in increased lagging chromosomes, leading to chromosome loss without accompanying chromosome gain in RNF4(-/-) cells. We therefore propose that RNF4 plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity. PMID:25205350

  13. Preventive effects of bee pollen Cistus ladaniferus extract on bone loss in ovariectomized rats in vivo

    International Nuclear Information System (INIS)

    The effect of bee pollen Cistus ladaniferus extract on ovariectomy (OVX)-induced bone loss in vivo was investigated. The water-solubilized extracts were obtained from the bee pollen of Cistus ladaniferus. Cistus extract (5.0 or 10.0 mg/100 g body weight) was orally administered once daily for 30 days to OVX rats. The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX-induced a significant decrease in mineral content, mineral density, and polar strength strain index in the femoral-metaphyseal tissues. These decreases were significantly prevented after the administration of Cistus extract (10.0 mg/100 g). Moreover, OVX-induced a significant decrease in calcium content in the femoral-diaphyseal and -metaphyseal tissues. This decrease was significantly prevented after the administration of cistus extract (5.0 or 10.0 mg/100 g). This study demonstrates that cistus extract has a preventive effect on OVX-induced bone loss in vivo. (author)

  14. Evaluation of pool swell velocity during large break loss of coolant accident in boiling water reactor Mark III containment design

    Energy Technology Data Exchange (ETDEWEB)

    Yan Jin, E-mail: jinyan10@gmail.co [GE-Hitachi Nuclear Energy, 3901 Castle Hayne Road, Wilmington, M/L-30, NC 28402 (United States); Bolger, Francis [GE-Hitachi Nuclear Energy, 3901 Castle Hayne Road, Wilmington, M/L-30, NC 28402 (United States)

    2010-07-15

    In boiling water reactor (BWR) design, safety scenarios such as main steam line break need to be evaluated. After the main steam line break, the steam will fill the upper dry well of the containment. It will then enter the vertical vent and eventually flow into the suppression pool via horizontal vents. The steam will create large bubbles in the suppression pool and cause the pool to swell. The impact of the pool swell on the equipment inside the pool and containment structure needed to be evaluated for licensing. GE has conducted a series of one-third scale three-vent air tests in supporting the horizontal vent pressure suppression system used in Mark III containment design for General Electric BWR plants. During the test, the air-water interface locations were tracked by conductivity probes. The pressure was measured at many locations inside the test rig as well. The purpose of the test was to provide a basis for the pool swell load definition for the Mark III containment. In this paper, a transient three-dimensional CFD model to simulate the one-third scale Mark III suppression pool swell process is illustrated. The Volume of Fluid (VOF) multiphase model is used to explicitly track the interface between the water liquid and the air. The CFD results such as flow velocity, pressure, interface locations are compared to the data from the test. Through comparisons, a technical approach to numerically model the pool swell phenomenon is established and benchmarked.

  15. Evaluation of pool swell velocity during large break loss of coolant accident in boiling water reactor Mark III containment design

    International Nuclear Information System (INIS)

    In boiling water reactor (BWR) design, safety scenarios such as main steam line break need to be evaluated. After the main steam line break, the steam will fill the upper dry well of the containment. It will then enter the vertical vent and eventually flow into the suppression pool via horizontal vents. The steam will create large bubbles in the suppression pool and cause the pool to swell. The impact of the pool swell on the equipment inside the pool and containment structure needed to be evaluated for licensing. GE has conducted a series of one-third scale three-vent air tests in supporting the horizontal vent pressure suppression system used in Mark III containment design for General Electric BWR plants. During the test, the air-water interface locations were tracked by conductivity probes. The pressure was measured at many locations inside the test rig as well. The purpose of the test was to provide a basis for the pool swell load definition for the Mark III containment. In this paper, a transient three-dimensional CFD model to simulate the one-third scale Mark III suppression pool swell process is illustrated. The Volume of Fluid (VOF) multiphase model is used to explicitly track the interface between the water liquid and the air. The CFD results such as flow velocity, pressure, interface locations are compared to the data from the test. Through comparisons, a technical approach to numerically model the pool swell phenomenon is established and benchmarked.

  16. Isokinetic eccentric resistance training prevents loss in mechanical muscle function after running

    DEFF Research Database (Denmark)

    Oliveira, Anderson S. C.; Caputo, Fabrizio; Aagaard, Per;

    2013-01-01

    The aim of the study was to verify whether 8 weeks of resistance training employing maximal isokinetic eccentric (IERT) knee extensor actions would reduce the acute force loss observed after high-intensity treadmill running exercise. It was hypothesized that specific IERT would induce protective...... effects against muscle fatigue and ultrastructural damages, preventing or reducing the loss in mechanical muscle function after running. Subjects were tested before and after IERT protocol for maximal isometric, concentric and eccentric isokinetic knee extensor strength (60° and 180° s(-1)). In a second...... session, subjects performed treadmill running (~35 min) and the previously mentioned measurements were repeated immediately after running. Subsequently, subjects were randomized to training (n = 12) consisting of 24 sessions of maximal IERT knee extensors actions at 180° s(-1), or served as controls (n...

  17. The Lampedusa Disaster: How to Prevent Further Loss of Life at Sea?

    Directory of Open Access Journals (Sweden)

    Jasmine Coppens

    2013-12-01

    Full Text Available Lampedusa – an Italian island barely 70 miles from northern Africa and 100 miles from Malta – has become a gateway to Europe for migrants. In some seasons, boats filled with asylum seekers arrive almost daily. However, yearly, hundreds of people die trying to cross the Mediterranean Sea. This paper will deal with the obligations of States towards seaborne migrants, the question of why so many people die near Lampedusa and the possible solutions in order to prevent further loss of life at sea.

  18. Black Lucques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats.

    Science.gov (United States)

    Puel, Caroline; Mardon, Julie; Kati-Coulibaly, Séraphin; Davicco, Marie-Jeanne; Lebecque, Patrice; Obled, Christiane; Rock, Edmond; Horcajada, Marie-Noelle; Agalias, Apostolos; Skaltsounis, Leandros A; Coxam, Véronique

    2007-05-01

    This study was conducted to determine whether olive fruits, rich in micronutrients, might improve bone loss in ovariectomized (OVX) rats (an experimental model of postmenopausal osteoporosis) and in OVX rats with granulomatosis inflammation (a model of senile osteoporosis). Six-month-old Wistar female rats underwent ovariectomy and were then immediately treated orally by substituting oil in the diet by 10 g/d green Lucques olives or 6 g/d black Lucques olives for each rat for 84 days. OVX rats and sham-operated controls received the same diet with oil. Three weeks before the end of the experiment, subcutaneous inflammation was provoked by injections of sterile magnesium silicate in half the animals in each group. In OVX rats, granulomatosis inflammation, characterized by a rise in inflammatory parameters such as fibrinogen, alpha1-acid glycoprotein, spleen weight and granulocyte level, and an impairment of oxidative status (as shown by a decrease in plasma antioxidant capacity, a higher rate of isoprostane excretion) elicited a bone loss in the whole femur and in the metaphyseal areas considered on their own. Whereas green olives had no effect on osteopenia, consumption of the black variety prevented bone loss in the whole femur and at cortical sites in those oestrogen-deficient animals with talc inflammation (diaphyseal bone mineral density: black olives and inflammation 0-2323 (SE 0.0026) v. ovariectomy and inflammation 0.2117 (SE 0.0030); P=0.027). This bone-sparing effect seemed to result from an improvement in the inflammatory and oxidative status. The present data show that black olives are able to prevent bone loss in an experimental model of senile osteoporosis (oestrogen-deficient rats in which a low-grade inflammation was induced by talc injection). PMID:17408530

  19. A study on effective system depressurization during a PWR vessel bottom break LOCA with HPI failure and gas inflow prevention. ROSA-V/LSTF test SB-PV-05

    International Nuclear Information System (INIS)

    A small break loss-of-coolant accident (SBLOCA) experiment was conducted at the Large Scale Test Facility (LSTF) of ROSA-V program to study effects of accident management (AM) measures on core cooling, which are important in case of total failure of high pressure injection (HPI) system during an SBLOCA at a pressurized water reactor (PWR). The LSTF is a full-height and 1/48 volume-scaled facility simulating a 4-loop Westinghouse-type PWR (3423 MWt). The experiment, SB-PV-05, simulated a PWR vessel bottom SBLOCA with a rupture of nine instrument tubes, which is equivalent to 0.18% cold leg break. It is clarified that AM actions with steam generator (SG) depressurization to achieve a primary loop cooling rate at -55 K/h and auxiliary feedwater supply for 30 minutes are effective to avoid core uncovery by actuating the low pressure injection (LPI) system. It is also shown through the comparison with the previous experiment of SB-PV-03 that prevention of non-condensable gas inflow from the accumulator injection system (AIS) is very important to actuate the LPI to achieve adequate core cooling. This report presents experiment results of SB-PV-05 in detail and shows the effects of gas inflow prevention on core cooling through the estimation of primary coolant mass and energy balance in the primary system. (author)

  20. A Multi-Layer Intelligent Loss-of-Control Prevention System (LPS) for Flight Control Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The main objective of the proposed work is to design and develop a multi-layer intelligent Loss-of-control Prevention System (LPS) for flight control applications....

  1. Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation

    Science.gov (United States)

    Dou, Ce; Cao, Zhen; Ding, Ning; Hou, Tianyong; Luo, Fei; Kang, Fei; Yang, Xiaochao; Jiang, Hong; Xie, Zhao; Hu, Min; Xu, Jianzhong; Dong, Shiwu

    2016-01-01

    Cordycepin was previously reported to have anti-tumor, anti-inflammatory and anti-oxidant activity. However, the potential role of cordycepin in bone metabolism and cell biology of osteoclasts remains unclear. In our study, we focused on the in vitro effects of cordycepin on osteoclastogenesis and its in vivo effects in ovariectomized (OVX) mice. Osteoclast differentiation, formation and fusion were evaluated by Tartrate-resistant acid phosphatase (TRAP) stain, focal adhesion stain and fusion assay, respectively. Osteoclastic bone resorption was evaluated by pit formation assay. Reactive oxygen species (ROS) generation and removal were detected by the ROS assay. OVX mice were orally administered with 10 mg/kg of cordycepin daily for four weeks. In vitro results revealed that cordycepin inhibited receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation, formation, fusion and bone resorption activity. We further proved that cordycepin treatments scavenged the generation of ROS, upregulated interferon regulatory factor 8 (IRF-8) and suppressed the activity of nuclear factor of activated T cells c1 (NFATc1) during osteoclastogenesis. In vivo results indicated cordycepin prevents bone loss, rescues bone microarchitecture, and restores bone mineralization in OVX mice. Our observations strongly suggested that cordycepin is an efficient osteoclast inhibitor and hold potential therapeutic value in preventing bone loss among postmenopausal osteoporosis patients. PMID:27104563

  2. TRAC-PF1/MOD1 calculations and data comparisons for MIST [Multi-Loop Integral System Test] small-break loss-of-coolant accidents with scaled 10 cm2 and 50 cm2 breaks

    International Nuclear Information System (INIS)

    Los Alamos National Laboratory is a participant in the Integral System Test (IST) program initiated in June 1983 for the purpose of providing integral system test data on specific issues/phenomena relevant to post-small-break loss-of-coolant accidents (SBLOCAs), loss of feedwater and other transients in Babcock and Wilcox (B and W) plant designs. The Multi-Loop Integral System Test (MIST) facility is the largest single component in the IST program. MIST is a 2 x 4 (2 hot legs and steam generators, 4 cold legs and reactor-coolant pumps) representation of lowered-loop reactor systems of the B and W design. It is a full-height, full-pressure facility with 1/817 power and volume scaling. Two other experimental facilities are included in the IST program: test loops at the University of Maryland, College Park, and at Stanford Research Institute. The objective of the IST tests is to generate high-quality experimental data to be used for assessing thermal-hydraulic safety computer codes. Efforts are underway at Los Alamos to assess TRAC-PF1/MOD1 against data from each of the IST facilities. Calculations and data comparisons for TRAC-PF1/MOD1 assessment have been completed for two transients run in the MIST facility. These are the MIST nominal test. Test 3109AA, a scaled 10 cm2 SBLOCA and Test 320201, a scaled 50 cm2 SBLOCA. Only MIST assessment results are presented in this paper

  3. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells.

    Science.gov (United States)

    Zhang, Jian; Lazarenko, Oxana P; Blackburn, Michael L; Badger, Thomas M; Ronis, Martin J J; Chen, Jin-Ran

    2013-06-01

    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation. However, the role of degraded collagen matrix in the fate of resident bone-forming cells is unclear. In this report, we show that OVX-induced bone loss is associated with profound decreases in collagen 1 and Sirt1. This was accompanied by increases in expression and activity of the senescence marker collagenase and expression of p16/p21 in bone. Feeding a diet supplemented with blueberries (BB) to pre-pubertal rats throughout development or only prior to puberty [postnatal day 21 (PND21) to PND34] prevents OVX-induced effects on expression of these molecules at PND68. In order to provide more evidence and gain a better understanding on the association between bone collagen matrix and resident bone cell fate, in vitro studies on the cellular senescence pathway using primary calvarial cells and three cell lines (ST2 cells, OB6, and MLO-Y4) were conducted. We found that senescence was inhibited by collagen in a dose-response manner. Treatment of cells with serum from OVX rats accelerated osteoblastic cell senescence pathways, but serum from BB-fed OVX rats had no effect. In the presence of low collagen or treatment with OVX rat serum, ST2 cells exhibited higher potential to differentiate into adipocytes. Finally, we demonstrated that bone cell senescence is associated with decreased Sirt1 expression and activated p53, p16, and p21. These results suggest that (1) a significant prevention of OVX-induced bone cell senescence from adult rats can occur after only 14 days consumption of a BB-containing diet immediately prior to puberty, and (2) the molecular mechanisms underlying this effect involves, at least in part, prevention of collagen degradation. PMID:22555620

  4. Implications of Postharvest Food Loss/Waste Prevention to Energy and Resources Conservation

    Science.gov (United States)

    Cai, X.; Shafiee-Jood, M.

    2015-12-01

    World's growing demand for food is driven by population and income growth, dietary changes, and the ever-increasing competition between food, feed and bioenergy challenges food security; meanwhile agricultural expansion and intensification threats the environment by the various detrimental impacts. Researchers have attempted to explore strategies to overcome this grand challenge. One of the promising solutions that have attracted considerable attention recently is to increase the efficiency of food supply chain by reducing food loss and waste (FLW). According to recent studies conducted by Food and Agriculture Organization (FAO), United Nation, almost one third of the food produced for human consumption globally is lost or wasted along the food supply chain. This amount of food discarded manifests a missing, yet potential, opportunity to sustainably enhance both food security and environmental sustainability. However, implementing the strategies and technologies for tackling FLW does not come up as an easy solution since it requires economic incentives, benefit and cost analysis, infrastructure development, and appropriate market mechanism. In this presentation I will provide a synthesis of knowledge on the implications of postharvest food loss/waste prevention to energy and resource conservation, environmental protection, as well as food security. I will also discuss how traditional civil and environmental engineering can contribute to the reduction of postharvest food loss, an important issue of sustainable agriculture.

  5. Prevention of losses for hog farmers in China: insurance, on-farm biosecurity practices, and vaccination.

    Science.gov (United States)

    Zhang, Yue-hua; Li, Chu-Shiu; Liu, Chwen-Chi; Chen, Kevin Z

    2013-10-01

    Using agricultural household survey data and claim records from insurers in China, this paper analyzes hog producers' choice of the ways to prevent possible losses and identifies the relationships among biosecurity practices, vaccination, and hog insurance. By combining one probit and two structural equations, we adopt three-stage estimations by a mixed-process model to obtain results. The findings indicate that biosecurity practices provide the basic infrastructure for operating pig farms and complement both the usage of quality vaccines and the uptake of hog insurance. In addition, there is a strong substitution relationship between the quality of vaccine and the demand for hog insurance. Hog farmers that implement better biosecurity practices are more likely to seek high-quality vaccines or buy into hog insurance schemes, but not both. For those households with hog insurance, better biosecurity status, better management practices, and higher-quality vaccines significantly help to reduce loss ratios. However, we also find a moral hazard effect in that higher premium expenditures by the insured households might induce larger loss ratios. PMID:23870329

  6. THYDE-B1/MOD1: a computer code for analysis of small-break loss-of-coolant accident of boiling water reactors

    International Nuclear Information System (INIS)

    THYDE-B1/MOD1 is a computer code to analyze thermo-hydraulic transients of the reactor cooling system of a BWR, mainly during a small-break loss-of-coolant accidnet (SB-LOCA) with a special emphasis on the behavior of pressure and mixture level in the pressure vessel. The coolant behavior is simulated with a volume-and-junction method based on assumptions of thermal equilibrium and homogeneous conditions for two-phase flow. A characteristic feature of this code is a three-region representation of the state of the coolant in a control volume, in which three regions, i.e., subcooled liquid, saturated mixture and saturated steam regions are allowed to exist. The regions are separated by moving boundaries, tracked by mass and energy balances for each region. The interior of the pressure vessel is represented by two volumes with three regions: one for inside of the shroud and the other for outside, while other portions of the system are treated with homogeneous model. This method, although it seems to be very simple, has been verified to be adequate for cases of BWR SB-LOCAs in which the hydraulic transient is relatively slow and the cooling of the core strongly depends on the mixture level behavior in the vessel. In order to simulate the system behavior, THYDE-B1 is provided with analytical models for reactor kinetics, heat generation and conduction in fuel rods and structures, heat transfer between coolant and solid surfaces, coolant injection systems, breaks and discharge systems, jet pumps, recirculation pumps, and so on. The verification of the code has been conducted. A good predictability of the code has been indicated through the comparison of calculated results with experimental data provided by ROSA-III small-break tests. This report presents the analytical models, solution method, and input data requirements of the THYDE-B1/MOD1 code. (author)

  7. Sclerostin antibody prevented progressive bone loss in combined ovariectomized and concurrent functional disuse.

    Science.gov (United States)

    Zhang, Dongye; Hu, Minyi; Chu, Timothy; Lin, Liangjun; Wang, Jingyu; Li, Xiaodong; Ke, Hua Zhu; Qin, Yi-Xian

    2016-06-01

    Osteoporosis is characterized by low bone mass and compromised trabecular architecture, and is commonly occurred in post-menopausal women with estrogen deficiency. In addition, prolonged mechanical unloading, i.e., long term bed rest, can exaggerate the bone loss. Sclerostin is a Wnt signaling antagonist and acts as a negative regulator for bone formation. A sclerostin-neutralizing antibody (Scl-Ab) increased bone mineral density in women with postmenopausal osteoporosis and healthy men. The objective of this study was to characterize the condition of bone loss in ovariectomized (OVX) rats with concurrent mechanical unloading and evaluate the effect of sclerostin antibody treatment in mitigating the prospective severe bone loss conditions in this model. Four-month-old OVX- or sham-operated female SD rats were used in this study. They were subjected to functional disuse induced by hind-limb suspension (HLS) or free ambulance after 2days of arrival. Subcutaneous injections with either vehicle or Scl-Ab at 25mg/kg were made twice per week for 5weeks from the time of HLS. μCT analyses demonstrated a significant decrease in distal metaphyseal trabecular architecture integrity with HLS, OVX and HLS+OVX (bone volume fraction decreased by 29%, 71% and 87% respectively). The significant improvements of various trabecular bone parameters (bone volume fraction increased by 111%, 229% and 297% respectively as compared with placebo group) with the administration of Scl-Ab are associated with stronger mechanical property and increased bone formation by histomorphometry. These results together indicate that Scl-Ab prevented the loss of trabecular bone mass and cortical bone strength in OVX rat model with concurrent mechanical unloading. The data suggested that monoclonal sclerostin-neutralizing antibody represents a promising therapeutic approach for severe osteoporosis induced by estrogen deficiency with concurrent mechanical unloading. PMID:26868528

  8. TRAC analysis of an 80% pump-side, cold-leg, large-break loss-of-coolant accident for the Westinghouse AP600 advanced reactor design

    International Nuclear Information System (INIS)

    An updated TRAC 80% pump-side, cold-leg, large-break (LB) loss-of-coolant accident (LOCA) has been calculated for the Westinghouse AP600 advanced reactor design. The updated calculation incorporates major code error corrections, model corrections, and plant design changes. The break size and location were calculated by Westinghouse to be the most severe LBLOCA for the AP600 design. The LBLOCA transient was calculated to 280 s, which is the time of in-containment refueling water-storage-tank injection. All fuel rods were quenched completely by 240 s. Peak cladding temperatures (PCTs) were well below the licensing limit of 1,478 K (2,200 F) but were very near the cladding oxidation temperature of 1,200 K (1,700 F). Transient event times and PCTs for the TRAC calculation were in reasonable agreement with those calculated by Westinghouse using their WCOBRA/TRAC code. However, there were significant differences in the detailed phenomena calculated by the two codes, particularly during the blowdown and refill periods. The reasons for these differences are still being investigated

  9. Source term analysis in severe accident induced by large break loss of coolant accident coincident with ship blackout for ship reactor

    International Nuclear Information System (INIS)

    Using MELCOR code, the accident analysis model was established for a ship reactor. The behaviors of radioactive fission products were analyzed in the case of severe accident induced by large break loss of coolant accident coincident with ship blackout. The research mainly focused on the behaviors of release, transport, retention and the final distribution of inert gas and CsI. The results show that 83.12% of inert gas releases from the core, and the most of inert gas exists in the containment. About 83.08% of CsI release from the core, 72.66% of which is detained in the debris and the primary system, and 27.34% releases into the containment. The results can give a reference for the evaluation of cabin dose and nuclear emergency management. (authors)

  10. Post test calculation of the experiment `small break loss-of- coolant test` SBL-22 at the Finnish integral test facility PACTEL with the thermohydraulic code ATHLET

    Energy Technology Data Exchange (ETDEWEB)

    Lischke, W.; Vandreier, B. [Univ. for Applied Sciences, Zittau/Goerlitz (Germany). Dept. of Nuclear Technology

    1997-12-31

    At the University for Applied Sciences Zittau/Goerlitz (FH) calculations for the verification of the ATHLET-code for reactors of type VVER are carried out since 1991, sponsored by the German Ministry for Education, Science and Technology (BMBF). The special features of these reactors in comparison to reactors of western countries are characterized by the duct route of reactor coolant pipes and the horizontal steam generators. Because of these special features, a check of validity of the ATHLET-models is necessary. For further verification of the ATHLET-code the post test calculation of the experiment SBL-22 (Small break loss-of-coolant test) realized at the finnish facility PACTEL was carried out. The experiment served for the examination of the natural circulation behaviour of the loop over a continuous range of primary side water inventory. 5 refs.

  11. Results of Semiscale Mod-2C small-break (5%) loss-of-coolant accident. Experiments S-LH-1 and S-LH-2

    International Nuclear Information System (INIS)

    Two experiments simulating small break (5%) loss-of-coolant accidents (5% SBLOCAs) were performed in the Semiscale Mod-2C facility. These experiments were identical except for downcomer-to-upper-head bypass flow (0.9% in Experiment S-LH-1 and 3.0% in Experiment S-LH-2) and were performed at high pressure and temperature [15.6 MPa (2262 psia) system pressure; 37 K (670F) core differential temperature; 595 K(6100F) hot leg fluid temperature]. From the experimental results, the signature response and transient mass distribution are determined for a 5% SBLOCA. The core thermal-hydraulic response is characterized, including core void distribution maps, and the effect of core bypass flow on transient severity is assessed. Comparisons are made between postexperiment RELAP5 calculations and the experimental results, and the capability of RELAP5 to calculate the phenomena is assessed. 115 figs

  12. Prevention of the Evolution of Workers' Hearing Loss from Noise-Induced Hearing Loss in Noisy Environments through a Hearing Conservation Program.

    Science.gov (United States)

    Fonseca, Vinicius Ribas; Marques, Jair; Panegalli, Flavio; Gonçalves, Claudia Giglio de Oliveira; Souza, Wesley

    2016-01-01

    Introduction Noise-induced hearing loss (NIHL) is a serious problem for workers and therefore for businesses. The hearing conservation program (HCP) is a set of coordinated measures to prevent the development or evolution of occupational hearing loss, which involves a continuous and dynamic process of implementation of hearing conservation routines through anticipation, recognition, evaluation, and subsequent control of the occurrence of existing environmental risks or of those that may exist in the workplace and lead to workers' hearing damage. Objective The aim of this study was to evaluate the effectiveness of the HCP in preventing further hearing loss in workers with audiograms suggestive of NIHL. The audiometric tests and medical records of 28 furniture company workers exposed to noise were reviewed and monitored for 2 years. Methods This retrospective, cross-sectional study examined five audiometric tests in the medical records (on admission and every semester) of 28 workers in a furniture company (totaling 140 audiometric exams) following the introduction of the HCP. Results Data analysis showed no differences between the audiometric tests conducted on admission and those performed every semester. Conclusions The HCP implemented was effective in preventing the worsening of hearing loss in workers already with NIHL when exposed to occupational noise. Therefore, such a measure could be useful for the employment of workers with hearing loss in job sectors that have noise exposure. PMID:26722345

  13. Prevention of the Evolution of Workers' Hearing Loss from Noise-Induced Hearing Loss in Noisy Environments through a Hearing Conservation Program

    Science.gov (United States)

    Fonseca, Vinicius Ribas; Marques, Jair; Panegalli, Flavio; Gonçalves, Claudia Giglio de Oliveira; Souza, Wesley

    2015-01-01

    Introduction Noise-induced hearing loss (NIHL) is a serious problem for workers and therefore for businesses. The hearing conservation program (HCP) is a set of coordinated measures to prevent the development or evolution of occupational hearing loss, which involves a continuous and dynamic process of implementation of hearing conservation routines through anticipation, recognition, evaluation, and subsequent control of the occurrence of existing environmental risks or of those that may exist in the workplace and lead to workers' hearing damage. Objective The aim of this study was to evaluate the effectiveness of the HCP in preventing further hearing loss in workers with audiograms suggestive of NIHL. The audiometric tests and medical records of 28 furniture company workers exposed to noise were reviewed and monitored for 2 years. Methods This retrospective, cross-sectional study examined five audiometric tests in the medical records (on admission and every semester) of 28 workers in a furniture company (totaling 140 audiometric exams) following the introduction of the HCP. Results Data analysis showed no differences between the audiometric tests conducted on admission and those performed every semester. Conclusions The HCP implemented was effective in preventing the worsening of hearing loss in workers already with NIHL when exposed to occupational noise. Therefore, such a measure could be useful for the employment of workers with hearing loss in job sectors that have noise exposure. PMID:26722345

  14. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.

    Directory of Open Access Journals (Sweden)

    Philippe A Parone

    Full Text Available Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventing mitochondrial fission, by down-regulating expression of Drp1 in mammalian cells leads to a loss of mitochondrial DNA and a decrease of mitochondrial respiration coupled to an increase in the levels of cellular reactive oxygen species (ROS. At the cellular level, mitochondrial dysfunction resulting from the lack of fission leads to a drop in the levels of cellular ATP, an inhibition of cell proliferation and an increase in autophagy. In conclusion, we propose that mitochondrial fission is required for preservation of mitochondrial function and thereby for maintenance of cellular homeostasis.

  15. Analysis of a simulated small break in the semiscale system under loss-of-coolant accident conditions

    International Nuclear Information System (INIS)

    The Semiscale Mod-1 experimental program conducted by EG and G Idaho, Inc., is part of the overall U.S. Nuclear Regulatory Commission (NRC) and Department of Energy (DOE) sponsored research and development program to investigate the behavior of the pressurized water reactor (PWR) system during an hypothesized loss-of-coolant accident (LOCA). The Semiscale Mod-1 program is intended to provide transient thermal-hydraulic data from a simulated LOCA using a small-scale experimental nonnuclear system. The Semiscale Mod-1 program is a major contributor of experimental data that provide a means of evaluating the adequacy of overall system analytical models as well as the models of the individual system components. Selected experimental data produced by this program will also be used to aid other DOE and NRC sponsored experimental programs, such as the Loss-of-Fluid Test (LOFT) program in optimizing test series, selecting test parameters, and evaluating test results. The Semiscale Mod-1 tests are performed with an experimental system which simulates the principal features of a nuclear plant but which is smaller in volume. Nuclear heating is simulated in the tests by a core composed of an array of electrically heated rods. The core is contained in a pressure vessel which also includes a downcomer, lower plenum, and upper plenum. The Semiscale system piping is arranged such that the intact loop represents three loops of a four-loop nuclear plant, and the broken loop represents the fourth loop. In the present configuration the intact loop contains an active steam generator and pump, and the broken loop contains passive simulators for the steam generator and pump

  16. Prevention and Control of Losses of Gaseous Nitrogen Compounds in Livestock Operations: A Review

    Directory of Open Access Journals (Sweden)

    A.A. Jongebreur

    2001-01-01

    Full Text Available Nitrogen (N losses from livestock houses and manure storage facilities contribute greatly to the total loss of N from livestock farms. Volatilisation of ammonia (NH3 is the major process responsible for the loss of N in husbandry systems with slurry (where average dry matter content varies between 3 and 13%. Concerning this volatilisation of NH3, the process parameters of pH and air temperature are crucial. During a period of approximately 10 years, systematic measurements of NH3 losses originating from a large variety of different livestock houses were made. One of the problems with NH3 emissions is the large variation in the measured data due to the season, the production of the animals, the manure treatment, type of livestock house, and the manure storage. Generally speaking, prevention and control of NH3 emission can be done by control of N content in the manure, moisture content, pH, and temperature[1]. In houses for growing pigs, a combination of simple housing measures can be taken to greatly reduce NH33 emissions[2]. In houses for laying hens, the control of the manure drying process determines the emission of NH3[1]. Monteny[3] has built an NH3 production model with separate modules for the emission of the manure storage under the dairy house and the floor in the house. Manure spreading is also a major source of NH3 emission and is dependent on slurry composition, environmental conditions, and farm management. The effects of these factors have been employed in a model[4]. Losses via NO, N2O, and N2 are important in husbandry systems with solid manure and straw. The number of experimental data is, however, very limited. As N2O is an intermediate product of complex biochemical processes of nitrification and denitrification, optimal conditions are the key issues in N2O reduction strategies. We may expect that in the near future the emission of greenhouse gases will get the same attention from policy makers as NH3. Sustainable livestock

  17. Effective dissipation: breaking time-reversal symmetry

    CERN Document Server

    Brown, Aidan I

    2016-01-01

    At molecular scales, fluctuations play a significant role and prevent biomolecular processes from always proceeding in a preferred direction, raising the question of how limited amounts of free energy can be dissipated to obtain directed progress. We examine the system and process characteristics that efficiently break time-reversal symmetry at fixed energy loss; in particular for a simple model of a molecular machine, an intermediate energy barrier produces unusually high asymmetry for a given dissipation. Such insight into symmetry-breaking factors that produce particularly high time asymmetry suggests generalizations to a broader class of systems.

  18. Simulation of a large break loss of coolant (LBLOCA), without actuation of the emergency injection systems (ECCS) for a BWR-5

    International Nuclear Information System (INIS)

    In this paper the analysis of scenario for the loss of coolant case was realized with break at the bottom of a recirculation loop of a BWR-5 with containment type Mark II and a thermal power of 2317 MWt considering that not have coolant injection. This in order to observe the speed of progression of the accident, the phenomenology of the scenario, the time to reach the limit pressure of containment venting and the amount of radionuclides released into the environment. This simulation was performed using the MELCOR code version 2.1. The scenario posits a break in one of the shear recirculation loops. The emergency core cooling system (ECCS) and the reactor core isolation cooling (Rcic) have not credit throughout the event, which allowed achieve greater severity on scenario. The venting of the primary containment was conducted via valve of 30 inches instead of the line of 24 inches of wet well, this in order to have a larger area of exhaust of fission products directly to the reactor building. The venting took place when the pressure in the primary containment reached the 4.5 kg/cm2 and remained open for the rest of the scenario to maximize the amount released of radionuclides to the atmosphere. The safety relief valves were considered functional they do not present mechanical failure or limit their ability to release pressure due to the large number of performances in safety mode. The results of the analysis covers about 48 hours, time at which the accident evolution was observed; behavior of level, pressure in the vessel and the fuel temperature profile was analyzed. For progression of the scenario outside the vessel, the pressure and temperature of the primary containment, level and temperature of the suppression pool, the hydrogen accumulation in the container and the radionuclides mass released into the atmosphere were analyzed. (Author)

  19. Not Its Crowning Glory: Obstacles for FDA in Regulating Ingested Dietary Supplements Purporting to Prevent Hair Loss

    OpenAIRE

    Bradt, Andrew

    2005-01-01

    Preventing hair loss is big business in the United States, amounting to over one billion dollars per year. While the industry is dominated by FDA-approved medications, like Propecia and Rogaine and hair transplant surgeries, there are also a variety of herbal remedies on the market with no proof of effectiveness. These products are allowed to exist and to claim to regrow hair or prevent future hair loss thanks to the provisions of the Dietary Supplement Health and Education Act of 1994, or DS...

  20. Improving access to optometry services for people at risk of preventable sight loss: a qualitative study in five UK locations

    OpenAIRE

    Leamon, S.; Hayden, C.; Lee, H; Trudinger, D.; Appelbee, E.; Hurrell, D.-L.; Richardson, I.

    2014-01-01

    Background Reducing preventable sight loss is an increasing priority for public health and health care providers. We examined the factors affecting people's use of optometry services in population groups at increased risk of sight loss. Methods This is a qualitative study in five UK locations. In England, participants were from the Pakistani and Black Caribbean communities; in Scotland from the Pakistani community; and in Northern Ireland and Wales from white socio-economically deprived commu...

  1. The effects of different exercise modes for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats

    OpenAIRE

    Park, Jonghoon; Omi, Naomi

    2014-01-01

    [Purpose] Several epidemiological studies have demonstrated that there are positive correlations between vascular disorders and bone loss in postmenopausal women. The aim of the present study was to examine the effect of different types of exercise (e.g., climbing and swimming) for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats. [Methods] Twenty Sprague-Dawley female rats were randomly divided into three groups: ovariectomy (OVX) plus treatment with vitami...

  2. Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency.

    Science.gov (United States)

    Lam, Nga N; Triliana, Rahma; Sawyer, Rebecca K; Atkins, Gerald J; Morris, Howard A; O'Loughlin, Peter D; Anderson, Paul H

    2014-10-01

    There are several lines of evidence that demonstrate the ability of 1,25-dihydroxyvitamin D (1,25(OH)2D3), acting via the vitamin D receptor (VDR) to mediate negative or positive effects in bone. Transgenic over-expression of VDR in osteoblasts and osteocytes in a mouse model (OSVDR) has been previously shown to inhibit processes of bone resorption and enhance bone formation, under conditions of adequate calcium intake. While these findings suggest that vitamin D signalling in osteoblasts and osteocytes promotes bone mineral accrual, the vitamin D requirement for this action is not well understood. In this study, 4 week old female OSVDR and wild-type (WT) mice were fed either a vitamin D-replete (1000IU/kg diet, D+) or vitamin D-deficient (D-) diet for 4 months to observe changes to bone mineral homeostasis. Tibial bone mineral volume was analysed by micro-CT and changes to bone cell activities were measured using standard dynamic histomorphometric techniques. While vitamin D-deplete WT mice demonstrated a reduction in periosteal bone accrual and overall bone mineral volume, OSVDR mice, however, displayed increased cortical and cancellous bone volume in mice which remained higher during vitamin D-depletion due to a reduced osteoclast number and increased bone formation rate. These data suggest that increased VDR-mediated activity in osteoblast and osteocytes prevents bone loss due to vitamin D-deficiency. This article is part of a Special Issue entitled '16th Vitamin D Workshop'. PMID:24434283

  3. Evolutionary loss of light-harvesting proteins Lhcb6 and Lhcb3 in major land plant groups - break-up of current dogma.

    Science.gov (United States)

    Kouřil, Roman; Nosek, Lukáš; Bartoš, Jan; Boekema, Egbert J; Ilík, Petr

    2016-05-01

    Photosynthesis in plants and algae relies on the coordinated function of photosystems (PS) I and II. Their efficiency is augmented by finely-tuned light-harvesting proteins (Lhcs) connected to them. The most recent Lhcs (in evolutionary terms), Lhcb6 and Lhcb3, evolved during the transition of plants from water to land and have so far been considered to be an essential characteristic of land plants. We used single particle electron microscopy and sequence analysis to study architecture and composition of PSII supercomplex from Norway spruce and related species. We have found that there are major land plant families that lack functional lhcb6 and lhcb3 genes, which notably changes the organization of PSII supercomplexes. The Lhcb6 and Lhcb3 proteins have been lost in the gymnosperm genera Picea and Pinus (family Pinaceae) and Gnetum (Gnetales). We also revealed that the absence of these proteins in Norway spruce modifies the PSII supercomplex in such a way that it resembles its counterpart in the alga Chlamydomonas reinhardtii, an evolutionarily older organism. Our results break a deep-rooted concept of Lhcb6 and Lhcb3 proteins being the essential characteristic of land plants, and beg the question of what the evolutionary benefit of their loss could be. PMID:27001142

  4. Moderator analysis of the Wolsong Units 2/3/4 for the case of 35% RIH breaks with a loss of ECC injection using CFX-4.4

    International Nuclear Information System (INIS)

    A 3-D CFD model was developed for the transient simulation of the moderator circulation inside the Calandria vessel, using a commercial code CFX-4.4. To reduce the discretization errors in the reflector region, a set of butterfly-shaped grid structures were generated and used. The porous media approach was applied for the core region containing 380 Calandria tubes. A 3-dimensional hydraulic model for the porous core region has been developed based on the empirical pressure drop correlations. The transient moderator analysis was performed for the 35% RIH(Reactor Inlet Header) break with a loss of ECC(Emergency Core Cooling) injection, which gives the largest heat load to the moderator out of all the DBA's. During the initial 1200 seconds in the LOCA transient, the local subcooling near any PT/CT contact location does not go down below the minimum subcooling margin of 28oC, the experimentally derived threshold. It is concluded that film boiling on the Calandria tube surfaces would not occur during the selected LOCA scenario and thus the fuel channel integrity is maintained in the CANDU-6 reactor. (author)

  5. CHEMICAL PLANT SAFETY AND LOSS PREVENTION (Papers Presented at the International Symposium on Safety Control and Risk Management, SCRM)

    OpenAIRE

    Smith, Robert A.; Michigan, Midland

    1989-01-01

    Increased emphasis on safety and loss prevention over the last 50 years has engrained safety as one of the core values of The Dow Chemical Company. The safety emphasis starts at the very top, with the Environment, Health and Safety Committee of the Board

  6. Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT.

    Directory of Open Access Journals (Sweden)

    Linda Penn

    Full Text Available BACKGROUND: Prevalence of type 2 diabetes (T2D is increasing worldwide. T2D prevention by lifestyle intervention is effective. Pragmatic scalable interventions are needed, with evidence to efficiently target and monitor such interventions. We report pooled analyses of data from three European trial cohorts: to analyse T2D incidence, sustained weight loss and utility of risk predictors. METHODS: We analysed data on 749 adults with impaired glucose tolerance (278 men and 471 women, mean age 56 years, mean BMI 31 kgm(-2 recruited between 1993 and 2003, and randomised to intensive lifestyle intervention (I or lifestyle advice control (C. The intervention aimed to increase physical activity, modify diet, and promote weight loss≥5%. Using Cox-regression survival analysis, we assessed T2D incidence and the impact on T2D incidence of sustained weight loss, and of baseline cut-point values of FINDRISC score, fasting plasma glucose (FPG, and HbA1c. RESULTS: Mean follow-up duration was 3.1 years. T2D was diagnosed in 139 participants (I = 45/379, C = 94/370. Cumulative T2D incidence was 57% lower in the intervention compared with the control group (HR 0.42 (95% CI 0.29 to 0.60 P<0.001. Participants with ≥5% weight loss at one year had 65% lower T2D incidence (HR 0.35 (95% CI 0.22 to 0.56 P<0.001; maintaining ≥5% weight loss for two and three years further reduced T2D incidence. Recommended cut-points to identify those at high risk for T2D would have identified different proportions of European Diabetes Prevention Study (EDIPS participants with similar hazard-ratios for intervention effect. CONCLUSIONS: Pooled analysis of EDIPS trial data reinforces evidence for T2D prevention by lifestyle intervention. Analysis showed the preventive effect of ≥5% weight loss, especially if maintained long term, which has utility for intervention monitoring. Analysis of proposed cut-points demonstrates difficulties in balancing risk and benefit, to

  7. Prevention and Control of Losses of Gaseous Nitrogen Compounds in Livestock Operations: A Review

    OpenAIRE

    Jongebreur, A.A.; Monteny, G.J.

    2001-01-01

    Nitrogen (N) losses from livestock houses and manure storage facilities contribute greatly to the total loss of N from livestock farms. Volatilisation of ammonia (NH3) is the major process responsible for the loss of N in husbandry systems with slurry (where average dry matter content varies between 3 and 13%). Concerning this volatilisation of NH3, the process parameters of pH and air temperature are crucial. During a period of approximately 10 years, systematic measurements of NH3 losses or...

  8. Loss of platelet alpha 2-adrenergic receptors during simulated extracorporeal circulation: prevention with prostaglandin E1

    International Nuclear Information System (INIS)

    Cardiopulmonary bypass prolongs bleeding time and increases postoperative blood loss. During in vitro recirculation in an extracorporeal circuit containing a membrane oxygenator and primed with fresh heparinized human blood, the authors previously observed thrombocytopenia, impaired platelet aggregation, and depletion of granular contents, all of which were prevented with prostaglandin E1 (PGE1). To investigate these changes further, they studied the number and affinity of platelet alpha 2-adrenergic receptors by measuring the binding of 3H-yohimbine. Before recirculation, they found 235 alpha 2-adrenergic receptors per platelet, a Kd of 3.37 nmol/L, complete aggregation with 1.04 mumol/L epinephrine, and a platelet count of 281,000 microliters-1. After 2 minutes of recirculation, 9.44 mumol/L epinephrine was required to produce complete aggregation, and the platelet count was 104,000 microliters-1 (44% of control). After 2 hours of recirculation, the platelet count had increased to 123,000 microliters-1. However, epinephrine did not induce platelet aggregation even at 100 mumol/L. Moreover, alpha 2-adrenergic binding sites were not detectable, and affinity for yohimbine could not be calculated. Two minutes after PGE1 0.3 mumol/L was added to the circuit, platelet numbers, response to epinephrine, alpha 2-adrenergic binding sites per platelet, and affinity for yohimbine were not significantly different from control values. At 2 hours, the number of alpha 2-adrenergic sites was not significantly changed from control, but the affinity of yohimbine for platelets was significantly decreased 2.5-fold

  9. Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.

    Science.gov (United States)

    Garcia, Jose M; Chen, Ji-an; Guillory, Bobby; Donehower, Lawrence A; Smith, Roy G; Lamb, Dolores J

    2015-07-01

    Cisplatin administration induces DNA damage resulting in germ cell apoptosis and subsequent testicular atrophy. Although 50 percent of male cancer patients receiving cisplatin-based chemotherapy develop long-term secondary infertility, medical treatment to prevent spermatogenic failure after chemotherapy is not available. Under normal conditions, testicular p53 promotes cell cycle arrest, which allows time for DNA repair and reshuffling during meiosis. However, its role in the setting of cisplatin-induced infertility has not been studied. Ghrelin administration ameliorates the spermatogenic failure that follows cisplatin administration in mice, but the mechanisms mediating these effects have not been well established. The aim of the current study was to characterize the mechanisms of ghrelin and p53 action in the testis after cisplatin-induced testicular damage. Here we show that cisplatin induces germ cell damage through inhibition of p53-dependent DNA repair mechanisms involving gamma-H2AX and ataxia telangiectasia mutated protein kinase. As a result, testicular weight and sperm count and motility were decreased with an associated increase in sperm DNA damage. Ghrelin administration prevented these sequelae by restoring the normal expression of gamma-H2AX, ataxia telangiectasia mutated, and p53, which in turn allows repair of DNA double stranded breaks. In conclusion, these findings indicate that ghrelin has the potential to prevent or diminish infertility caused by cisplatin and other chemotherapeutic agents by restoring p53-dependent DNA repair mechanisms. PMID:26019260

  10. ESTIMATES OF KRASNOYARSK REGION BUDGET LOSSES DUE TO THE TAX SHORTFALLS FROM BUSINESSES RELATED WITH A TEMPORARY DISABILITY OF SMOKING EMPLOYEES AND THE REDUCTION IN LABOR INTENSITY DUE TO THE SMOKING BREAKS

    Directory of Open Access Journals (Sweden)

    Ivan Pavlovich Artuchov

    2013-10-01

    Full Text Available The aim of the paper is to estimate Krasnoyarsk region budget losses due to the shortfalls of taxes from businesses related with a temporary disability of smoking employees and the reduction of labor intensity due to the smoking breaks in 2011.In our work we used the method of economic losses estimation, developed by Conference Board of Canada.The following results were obtained. The estimation of tax shortfalls due to a temporary disability of smoking employees and decrease of labor intensity due to smoking breaks was carried out. It was obtained that Krasnoyarsk region budget losses as a result of the tax shortfalls are equal to 532.8 million rubles – due to increased sick absence risks among smokers and 3 414.3 million rubles – due to the lack of workers on the workplace during smoking breaks. Thus, it was found that the total budget losses of Krasnoyarsk region in 2011 reach 0.34% of the gross regional product.The obtained results can be used for the assessments of the economic losses.DOI: http://dx.doi.org/10.12731/2218-7405-2013-7-22

  11. Hearing loss prevention for carpenters: Part 1 - Using health communication and health promotion models to develop training that works

    Directory of Open Access Journals (Sweden)

    Carol Merry Stephenson

    2011-01-01

    Full Text Available In phase 1 of a large multiyear effort, health communication and health promotion models were used to develop a comprehensive hearing loss prevention training program for carpenters. Additionally, a survey was designed to be used as an evaluation instrument. The models informed an iterative research process in which the authors used key informant interviews, focus groups, and early versions of the survey tool to identify critical issues expected to be relevant to the success of the hearing loss prevention training. Commonly held attitudes and beliefs associated with occupational noise exposure and hearing losses, as well as issues associated with the use or non-use of hearing protectors, were identified. The training program was then specifically constructed to positively shape attitudes, beliefs, and behavioral intentions associated with healthy hearing behaviors - especially those associated with appropriate hearing protector use. The goal was to directly address the key issues and overcome the barriers identified during the formative research phase. The survey was finalized using factor analysis methods and repeated pilot testing. It was designed to be used with the training as an evaluation tool and thus could indicate changes over time in attitudes, beliefs, and behavioral intentions regarding hearing loss prevention. Finally, the training program was fine tuned with industry participation so that its delivery would integrate seamlessly into the existing health and safety training provided to apprentice carpenters. In phase 2, reported elsewhere in this volume, the training program and the survey were tested through a demonstration project at two sites.

  12. DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.

    Directory of Open Access Journals (Sweden)

    Wai Shan Yuen

    Full Text Available There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy. Double strand breaks (DSBs induced by ionizing radiation and agents such as neocarzinostatin (NCS, and interstrand crosslinks (ICLs induced by alkylating agents such as mitomycin C (MMC, are toxic DNA lesions that need to be repaired for cell survival. Here we examined the effects of NCS and MMC treatment on oocytes collected from antral follicles in mice, because potentially such oocytes are readily collected from ovaries and do not need to be in vitro grown to achieve meiotic competency. We found that oocytes were sensitive to NCS, such that this ionizing radiation mimetic blocked meiosis I and caused fragmented DNA. In contrast, MMC had no impact on the completion of either meiosis I or II, even at extremely high doses. However, oocytes treated with MMC did show γ-H2AX foci and following their in vitro maturation and parthenogenetic activation the development of the subsequent embryos was severely compromised. Addition of MMC to 1-cell embryos caused a similarly poor level of development, demonstrating oocytes have eventual sensitivity to this ICL-inducing agent but this does not occur during their meiotic division. In oocytes, the association of Fanconi Anemia protein, FANCD2, with sites of ICL lesions was not apparent until entry into the embryonic cell cycle. In conclusion, meiotic maturation of oocytes is sensitive to DSBs but not ICLs. The ability of oocytes to tolerate severe ICL damage and yet complete meiosis, means that this type of DNA lesion goes unrepaired in oocytes but impacts on subsequent embryo quality.

  13. Loss-of-feedwater, steam generator tube rupture, and steam line break experiments: Steam generator transient response test program: Interim report

    International Nuclear Information System (INIS)

    The Westinghouse Model Boiler No. 2 (MB-2) steam generator test model at the Engineering Test Facility in Tampa, Florida, was reinstrumented and modified for performing a series of tests simulating steam generator accident transients. The transients simulated were: loss of feed flow, steam generator tube rupture, and steam line break events. This document presents a description of (1) the model boiler and the associated test facility, (2) the tests performed, and (3) the analyses of the test results. Two LOF tests were analyzed in detail. Both tests were initiated from 100% power condition by shutting off the main feedwater flow. In LOF Test No. 1, the remaining boundary conditions were kept constant while in LOF Test No. 2, the power was rapidly reduced to 3%. The results show that the primary to secondary heat transfer becomes degraded when the collapsed water liquid level in the bundle region falls below approximately 50 inches. The SGTR test analyzed in detail - SGTR Test No. 2 - simulated the post-reactor-trip portion of the SGTR transient (T/sub prim/ = 5600F). The transient was initiated by starting the SGTR flow injection and simultaneously shutting off the auxiliary feedwater. The water level rose and flooded the dryer to its mid-elevation by the end of the test. The primary carry-over was shown to be less than 0.4% of the tracer mass injected into the secondary side by the SGTR flow. SGTR Test No. 3 investigated the response of the intact steam generator. Reverse heat transfer and low heat flow conditions were simulated. The results have demonstrated the occurrence of temperature stratification in the secondary water which lasted for about 800 seconds

  14. Uncertainty and sensitivity analysis for a nuclear power plant Large Break Loss of Coolant Accident (LB-LOCA) in the context of OECD BEMUSE programme

    International Nuclear Information System (INIS)

    The second comparative exercise performed as part of BEMUSE (Best Estimate Methods - Uncertainty and Sensitivity Evaluation) Programme, was devoted to Nuclear Power Plant (NPP) application. The BEMUSE programme has been promoted by the Working Group on Analysis and Management of Accidents (WGAMA) and endorsed by the Committee on the Safety of Nuclear Installations (CSNI). The programme was divided into two main steps. The first step was to perform an uncertainty and sensitivity analysis related to the LOFT L2-5 test, and the second step was to perform the same analysis for a Nuclear Power Plant Large Break Loss of Coolant Accident (LB-LOCA). The second step, also known as Phases IV and V, started in May 2006 and was finished in September 2009. Phase IV of BEMUSE Program is connected with previous Phase II, being a necessary step for an uncertainty analysis: the simulation of the reference scenario and sensitivity analysis. The selected plant was Zion 1 NPP, a 4 loop PWR unit. Thirteen participants coming from ten different countries have taken part in the Phase IV of the program. Phase V main objective was to obtain uncertainty bands for the maximum cladding temperature (time trend), upper plenum pressure (time trend), maximum peak cladding temperature (scalar), 1st peak cladding temperature (scalar), 2nd peak cladding temperature (scalar), time of accumulator injection (scalar), time of complete core quenching (scalar). Fourteen groups from twelve organizations and ten countries have participated in BEMUSE Phase V. Both Phases IV and V compared procedures with experience gained in the previous step of the programme. (author)

  15. Breaking Bat

    Science.gov (United States)

    Aguilar, Isaac-Cesar; Kagan, David

    2013-01-01

    The sight of a broken bat in Major League Baseball can produce anything from a humorous dribbler in the infield to a frightening pointed projectile headed for the stands. Bats usually break at the weakest point, typically in the handle. Breaking happens because the wood gets bent beyond the breaking point due to the wave sent down the bat created…

  16. Psychosocial Predictors of Weight Loss among American Indian and Alaska Native Participants in a Diabetes Prevention Translational Project

    Directory of Open Access Journals (Sweden)

    Edward J. Dill

    2016-01-01

    Full Text Available The association of psychosocial factors (psychological distress, coping skills, family support, trauma exposure, and spirituality with initial weight and weight loss among American Indians and Alaska Natives (AI/ANs in a diabetes prevention translational project was investigated. Participants (n=3,135 were confirmed as prediabetic and subsequently enrolled in the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP demonstration project implemented at 36 Indian health care programs. Measures were obtained at baseline and after completing a 16-session educational curriculum focusing on weight loss through behavioral changes. At baseline, psychological distress and negative family support were linked to greater weight, whereas cultural spirituality was correlated with lower weight. Furthermore, psychological distress and negative family support predicted less weight loss, and positive family support predicted greater weight loss, over the course of the intervention. These bivariate relationships between psychosocial factors and weight remained statistically significant within a multivariate model, after controlling for sociodemographic characteristics. Conversely, coping skills and trauma exposure were not significantly associated with baseline weight or change in weight. These findings demonstrate the influence of psychosocial factors on weight loss in AI/AN communities and have substantial implications for incorporating adjunctive intervention components.

  17. Psychosocial Predictors of Weight Loss among American Indian and Alaska Native Participants in a Diabetes Prevention Translational Project.

    Science.gov (United States)

    Dill, Edward J; Manson, Spero M; Jiang, Luohua; Pratte, Katherine A; Gutilla, Margaret J; Knepper, Stephanie L; Beals, Janette; Roubideaux, Yvette; Special Diabetes Program For Indians Diabetes Prevention Demonstration Project

    2016-01-01

    The association of psychosocial factors (psychological distress, coping skills, family support, trauma exposure, and spirituality) with initial weight and weight loss among American Indians and Alaska Natives (AI/ANs) in a diabetes prevention translational project was investigated. Participants (n = 3,135) were confirmed as prediabetic and subsequently enrolled in the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) demonstration project implemented at 36 Indian health care programs. Measures were obtained at baseline and after completing a 16-session educational curriculum focusing on weight loss through behavioral changes. At baseline, psychological distress and negative family support were linked to greater weight, whereas cultural spirituality was correlated with lower weight. Furthermore, psychological distress and negative family support predicted less weight loss, and positive family support predicted greater weight loss, over the course of the intervention. These bivariate relationships between psychosocial factors and weight remained statistically significant within a multivariate model, after controlling for sociodemographic characteristics. Conversely, coping skills and trauma exposure were not significantly associated with baseline weight or change in weight. These findings demonstrate the influence of psychosocial factors on weight loss in AI/AN communities and have substantial implications for incorporating adjunctive intervention components. PMID:26649314

  18. Preventing loss of independence through exercise (PLIE: a pilot clinical trial in older adults with dementia.

    Directory of Open Access Journals (Sweden)

    Deborah E Barnes

    Full Text Available Current dementia medications have small effect sizes, many adverse effects and do not change the disease course. Therefore, it is critically important to study alternative treatment strategies. The goal of this study was to pilot-test a novel, integrative group exercise program for individuals with mild-to-moderate dementia called Preventing Loss of Independence through Exercise (PLIÉ, which focuses on training procedural memory for basic functional movements (e.g., sit-to-stand while increasing mindful body awareness and facilitating social connection.We performed a 36-week cross-over pilot clinical trial to compare PLIÉ with usual care (UC at an adult day program for individuals with dementia in San Francisco, CA. Assessments of physical performance, cognitive function, physical function, dementia-related behaviors, quality of life and caregiver burden were performed by blinded assessors at baseline, 18 weeks (cross-over and 36 weeks. Our primary outcomes were effect sizes based on between-group comparisons of change from baseline to 18 weeks; secondary outcomes were within-group comparisons of change before and after cross-over.Twelve individuals enrolled (7 PLIÉ, 5 UC and 2 withdrew (1 PLIÉ, 18 weeks; 1 UC, 36 weeks. Participants were 82% women (mean age, 84 ± 4 years; caregivers were 82% daughters (mean age, 56 ± 13 years. Effect sizes were not statistically significant but suggested potentially clinically meaningful (≥ 0.25 SDs improvement with PLIÉ versus UC for physical performance (Cohen's D: 0.34 SDs, cognitive function (0.76 SDs and quality of life (0.83 SDs as well as for caregiver measures of participant's quality of life (0.33 SDs and caregiver burden (0.49 SDs. Results were similar when within-group comparisons were made before and after cross-over.PLIÉ is a novel, integrative exercise program that shows promise for improving physical function, cognitive function, quality of life and caregiver burden in individuals with

  19. Theories and Practice in Prevention and Treatment Principles in Relation to Chinese Herbal Medicine and Bone Loss

    Institute of Scientific and Technical Information of China (English)

    Hong Xu 徐红; David LAWSON

    2004-01-01

    Osteoporosis is a world wide problem that is increasing in significance as the global population both increases and ages. While osteoporosis has been extensively studied in recent years, the utilization of Traditional Chinese Herbal Medicine for the prevention and treatment of this condition have seldom been examined in the Western world. This paper reviews the theories and the literature that relate to prevention and treatment of bone loss at the time of menopause according to the principles of Traditional Chinese Herbal Medicine. Practical developments in these areas are also illustrated in this paper based on the authors' research findings in recent studies.

  20. Charts for Weight Loss to Detect Hypernatremic Dehydration and Prevent Formula Supplementing

    NARCIS (Netherlands)

    Dommelen, P. van; Boer, S.; Unal, S.; Wouwe, J.P. van

    2014-01-01

    BACKGROUND: Most breast-fed newborns get the milk they need. However, very rarely milk intake is insufficient mostly as a result of poor breastfeeding techniques. Dramatic weight loss and hypernatremic dehydration may occur. Our aim was to construct charts for weight loss. METHODS: A case-control st

  1. Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye.

    Directory of Open Access Journals (Sweden)

    Paulo M G Rodrigues

    Full Text Available Nibrin (NBN or NBS1 and ATM are key factors for DNA Double Strand Break (DSB signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivity, neurological developmental defects and cancer predisposition. However, the functional synergy of Nbn and Atm in different tissues and developmental stages is not yet understood. Here, we show in vivo consequences of conditional inactivation of both genes in neural stem/progenitor cells using Nestin-Cre mice. Genetic inactivation of Atm in the central nervous system of Nbn-deficient mice led to reduced life span and increased DSBs, resulting in increased apoptosis during neural development. Surprisingly, the increase of DSBs and apoptosis was found only in few tissues including cerebellum, ganglionic eminences and lens. In sharp contrast, we showed that apoptosis associated with Nbn deletion was prevented by simultaneous inactivation of Atm in developing retina. Therefore, we propose that Nbn and Atm collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner.

  2. Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss

    OpenAIRE

    Trouvin, Anne-Priscille; Goëb, Vincent

    2010-01-01

    Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is key to regulation for maintaining the balance between the activity of osteoblasts and osteoclasts in order to prevent bone loss and ensure a normal bone turnover. In this review, ...

  3. Hearing loss prevention for carpenters: Part 1 - Using health communication and health promotion models to develop training that works

    OpenAIRE

    Carol Merry Stephenson; Stephenson, Mark R.

    2011-01-01

    In phase 1 of a large multiyear effort, health communication and health promotion models were used to develop a comprehensive hearing loss prevention training program for carpenters. Additionally, a survey was designed to be used as an evaluation instrument. The models informed an iterative research process in which the authors used key informant interviews, focus groups, and early versions of the survey tool to identify critical issues expected to be relevant to the success of the hearing lo...

  4. Alpha-1 antitrypsin gene therapy prevented bone loss in ovariectomy induced osteoporosis mouse model

    Science.gov (United States)

    Osteoporosis is a major healthcare burden affecting mostly postmenopausal women characterized by compromised bone strength and increased risk of fragility fracture. Although pathogenesis of this disease is complex, elevated proinflammatory cytokine production is clearly involved in bone loss at meno...

  5. Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3.

    OpenAIRE

    Fishman, P; Falach-Vaknine, E; Zigelman, R; Bakimer, R; Sredni, B.; Djaldetti, M; Shoenfeld, Y

    1993-01-01

    Antiphospholipid antibodies are strongly associated with arterial and venous thrombosis and with fetal loss. Recently an experimental model for antiphospholipid syndrome (APLS) was established in our laboratory. In this model, mice are immunized passively or actively with anticardiolipin antibodies and acquire the syndrome, which is characterized by prolonged activated partial thromboplastin time (APTT), thrombocytopenia, low fecundity rate, and fetal loss. In a normal process of pregnancy, l...

  6. Application of realistic (best- estimate) methodologies for large break loss of coolant (LOCA) safety analysis: licensing of Westinghouse ASTRUM evaluation model in Spain

    International Nuclear Information System (INIS)

    When the LOCA Final Acceptance Criteria for Light Water Reactors was issued in Appendix K of 10CFR50 both the USNRC and the industry recognized that the rule was highly conservative. At that time, however, the degree of conservatism in the analysis could not be quantified. As a result, the USNRC began a research program to identify the degree of conservatism in those models permitted in the Appendix K rule and to develop improved thermal-hydraulic computer codes so that realistic accident analysis calculations could be performed. The overall results of this research program quantified the conservatism in the Appendix K rule and confirmed that some relaxation of the rule can be made without a loss in safety to the public. Also, from a risk-informed perspective it is recognized that conservatism is not always a complete defense for lack of sophistication in models. In 1988, as a result of the improved understanding of LOCA phenomena, the USNRC staff amended the requirements of 10 CFR 50.46 and Appendix K, 'ECCS Evaluation Models', so that a realistic evaluation model may be used to analyze the performance of the ECCS during a hypothetical LOCA. Under the amended rules, best-estimate plus uncertainty (BEPU) thermal-hydraulic analysis may be used in place of the overly prescriptive set of models mandated by Appendix K rule. Further guidance for the use of best-estimate codes was provided in Regulatory Guide 1.157 To demonstrate use of the revised ECCS rule, the USNRC and its consultants developed a method called the Code Scaling, Applicability, and Uncertainty (CSAU) evaluation methodology as an approach for defining and qualifying a best-estimate thermal-hydraulic code and quantifying the uncertainties in a LOCA analysis. More recently the CSAU principles have been generalized in the Evaluation Model Development and Assessment Process (EMDAP) of Regulatory Guide 1.203. ASTRUM is the Westinghouse Best Estimate Large Break LOCA evaluation model applicable to two-, three

  7. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model.

    Science.gov (United States)

    Britton, Robert A; Irwin, Regina; Quach, Darin; Schaefer, Laura; Zhang, Jing; Lee, Taehyung; Parameswaran, Narayanan; McCabe, Laura R

    2014-11-01

    Estrogen deficiency is a major risk factor for osteoporosis that is associated with bone inflammation and resorption. Half of women over the age of 50 will experience an osteoporosis related fracture in their lifetime, thus novel therapies are needed to combat post-menopausal bone loss. Recent studies suggest an important role for gut-bone signaling pathways and the microbiota in regulating bone health. Given that the bacterium Lactobacillus reuteri ATCC PTA 6475 (L. reuteri) secretes beneficial immunomodulatory factors, we examined if this candidate probiotic could reduce bone loss associated with estrogen deficiency in an ovariectomized (Ovx) mouse menopausal model. Strikingly, L. reuteri treatment significantly protected Ovx mice from bone loss. Osteoclast bone resorption markers and activators (Trap5 and RANKL) as well as osteoclastogenesis are significantly decreased in L. reuteri-treated mice. Consistent with this, L. reuteri suppressed Ovx-induced increases in bone marrow CD4+ T-lymphocytes (which promote osteoclastogenesis) and directly suppressed osteoclastogenesis in vitro. We also identified that L. reuteri treatment modifies microbial communities in the Ovx mouse gut. Together, our studies demonstrate that L. reuteri treatment suppresses bone resorption and loss associated with estrogen deficiency. Thus, L. reuteri treatment may be a straightforward and cost-effective approach to reduce post-menopausal bone loss. PMID:24677054

  8. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics.

    Science.gov (United States)

    Li, Jau-Yi; Chassaing, Benoit; Tyagi, Abdul Malik; Vaccaro, Chiara; Luo, Tao; Adams, Jonathan; Darby, Trevor M; Weitzmann, M Neale; Mulle, Jennifer G; Gewirtz, Andrew T; Jones, Rheinallt M; Pacifici, Roberto

    2016-06-01

    A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that the intestinal microbiota modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss. In murine models, sex steroid deficiency increased gut permeability, expanded Th17 cells, and upregulated the osteoclastogenic cytokines TNFα (TNF), RANKL, and IL-17 in the small intestine and the BM. In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogenic cytokine production, stimulate bone resorption, and cause trabecular bone loss, demonstrating that the gut microbiota is central in sex steroid deficiency-induced trabecular bone loss. Furthermore, we demonstrated that twice-weekly treatment of sex steroid-deficient mice with the probiotics Lactobacillus rhamnosus GG (LGG) or the commercially available probiotic supplement VSL#3 reduces gut permeability, dampens intestinal and BM inflammation, and completely protects against bone loss. In contrast, supplementation with a nonprobiotic strain of E. coli or a mutant LGG was not protective. Together, these data highlight the role that the gut luminal microbiota and increased gut permeability play in triggering inflammatory pathways that are critical for inducing bone loss in sex steroid-deficient mice. Our data further suggest that probiotics that decrease gut permeability have potential as a therapeutic strategy for postmenopausal osteoporosis. PMID:27111232

  9. Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss.

    Science.gov (United States)

    Newton, Joseph M; Schofield, Desmond; Vlahopoulou, Joanna; Zhou, Yuhong

    2016-07-01

    Monitoring the physical or chemical properties of cell broths to infer cell status is often challenging due to the complex nature of the broth. Key factors indicative of cell status include cell density, cell viability, product leakage, and DNA release to the fermentation broth. The rapid and accurate prediction of cell status for hosts with intracellular protein products can minimise product loss due to leakage at the onset of cell lysis in fermentation. This article reports the rheological examination of an industrially relevant E. coli fermentation producing antibody fragments (Fab'). Viscosity monitoring showed an increase in viscosity during the exponential phase in relation to the cell density increase, a relatively flat profile in the stationary phase, followed by a rapid increase which correlated well with product loss, DNA release and loss of cell viability. This phenomenon was observed over several fermentations that a 25% increase in broth viscosity (using induction-point viscosity as a reference) indicated 10% product loss. Our results suggest that viscosity can accurately detect cell lysis and product leakage in postinduction cell cultures, and can identify cell lysis earlier than several other common fermentation monitoring techniques. This work demonstrates the utility of rapidly monitoring the physical properties of fermentation broths, and that viscosity monitoring has the potential to be a tool for process development to determine the optimal harvest time and minimise product loss. © 2016 The Authors. Biotechnology Progress published by Wiley Periodicals, Inc. on behalf of American Institute of Chemical Engineers, 32:1069-1076, 2016. PMID:27111912

  10. American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults.

    Science.gov (United States)

    Jakicic, J M; Clark, K; Coleman, E; Donnelly, J E; Foreyt, J; Melanson, E; Volek, J; Volpe, S L

    2001-12-01

    In excess of 55% of adults in the United States are classified as either overweight (body mass index = 25-29.9 kg.m(-2)) or obese (body mass index > or = 30 kg.m(-2)). To address this significant public health problem, the American College of Sports Medicine recommends that the combination of reductions in energy intake and increases in energy expenditure, through structured exercise and other forms of physical activity, be a component of weight loss intervention programs. An energy deficit of 500-1000 kcal.d-1 achieved through reductions in total energy intake is recommended. Moreover, it appears that reducing dietary fat intake to exercise per week, and overweight and obese adults should progressively increase to this initial exercise goal. However, there may be advantages to progressively increasing exercise to 200-300 min (3.3-5 h) of exercise per week, as recent scientific evidence indicates that this level of exercise facilitates the long-term maintenance of weight loss. The addition of resistance exercise to a weight loss intervention will increase strength and function but may not attenuate the loss of fat-free mass typically observed with reductions in total energy intake and loss of body weight. When medically indicated, pharmacotherapy may be used for weight loss, but pharmacotherapy appears to be most effective when used in combination with modifications of both eating and exercise behaviors. The American College of Sports Medicine recommends that the strategies outlined in this position paper be incorporated into interventions targeting weight loss and the prevention of weight regain for adults. PMID:11740312

  11. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells

    OpenAIRE

    Zhang, Jian; Lazarenko, Oxana P.; Blackburn, Michael L.; Badger, Thomas M.; Ronis, Martin J. J.; Chen, Jin-Ran

    2012-01-01

    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation. However, the role of degraded collagen matrix in the fate of resident bone-forming cells is unclear. In this report, we show that OVX-induced bone loss is associated with profound decreases in collagen 1 and Sirt1. This was accompanied by increases in expression and activity of the senescence marker collagenase and expression of p16...

  12. Risky Business: Risk Management, Loss Prevention and Insurance Procurement for Colleges and Universities. NACUA Publication Series.

    Science.gov (United States)

    Bennett, Barbara

    No matter what type of insurance or how much actual coverage an individual college or university obtains, it will always pay for its own losses one way or another. This pamphlet is intended to assist colleges and universities to meet that challenge by providing administrators with a structure for analyzing and managing risks and determining the…

  13. Testing the effects of a message framing intervention on intentions towards hearing loss prevention in adolescents

    NARCIS (Netherlands)

    Bruijn, G.J. de; Spaans, P.; Jansen, B.; Riet, J.P. van 't

    2016-01-01

    Adolescent hearing loss is a public health problem that has eluded effective intervention. A persuasive message strategy was tested for its effectiveness on adolescents’ intention to listen to music at a reduced volume. The messages manipulated both type of message frame [positive consequence

  14. Testing the Effects of a Message Framing Intervention on Intentions towards Hearing Loss Prevention in Adolescents

    Science.gov (United States)

    de Bruijn, Gert-Jan; Spaans, Pieter; Jansen, Bastiaan; van't Riet, Jonathan

    2016-01-01

    Adolescent hearing loss is a public health problem that has eluded effective intervention. A persuasive message strategy was tested for its effectiveness on adolescents' intention to listen to music at a reduced volume. The messages manipulated both type of message frame [positive consequences of listening to music at a reduced volume…

  15. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells

    Science.gov (United States)

    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation. However, the role of degraded collagen matrix in the fate of resident bone-forming cells is unclear. In this report, we show that OVX-i...

  16. Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model

    OpenAIRE

    Britton, Robert A.; Irwin, Regina; Quach, Darin; Schaefer, Laura; Zhang, Jing; Lee, Taehyung; Parameswaran, Narayanan; McCabe, Laura R.

    2014-01-01

    Estrogen deficiency is a major risk factor for osteoporosis that is associated with bone inflammation and resorption. Half of women over the age of 50 will experience an osteoporosis related fracture in their lifetime, thus novel therapies are needed to combat post-menopausal bone loss. Recent studies suggest an important role for gut-bone signaling pathways and the microbiota in regulating bone health. Given that the bacterium Lactobacillus reuteri ATCC PTA 6475 (L. reuteri) secretes benefic...

  17. Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy

    OpenAIRE

    XU, XIN-CHEN; Chen, Hui; Zhang, Xi; ZHAI, ZAN-JING; Liu, Xu-qiang; Qin, An; Lu, Er-yi

    2014-01-01

    Background Periodontitis is an inflammatory disease characterized by the loss of connective tissue and alveolar bone. There is an increasing evidence that periodontitis is associated with a number of chronic disease, including osteoporosis. Periodontitis and osteoporosis are both bone destructive diseases and of high prevalence in adult population. Osteoporosis could increase some inflammatory factors that also participate in the progression of periodontitis, so as to facilitate the alveolar ...

  18. Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss

    OpenAIRE

    Newton, J. M.; Schofield, D.; Vlahopoulou, J.; Zhou, Y.

    2016-01-01

    Monitoring the physical or chemical properties of cell broths to infer cell status is often challenging due to the complex nature of the broth. Key factors indicative of cell status include cell density, cell viability, product leakage and DNA release to the fermentation broth. The rapid and accurate prediction of cell status for hosts with intracellular protein products can minimise product loss due to leakage at the onset of cell lysis in fermentation. This paper reports the rheological exa...

  19. Genetic and pharmacological intervention for treatment/prevention of hearing loss

    OpenAIRE

    Cotanche, Douglas A.

    2008-01-01

    Twenty years ago it was first demonstrated that birds could regenerate their cochlear hair cells following noise damage or aminoglycoside treatment. An understanding of how this structural and functional regeneration occurred might lead to the development of therapies for treatment of sensorineural hearing loss in humans. Recent experiments have demonstrated that noise exposure and aminoglycoside treatment lead to apoptosis of the hair cells. In birds, this programmed cell death induces the a...

  20. Erythropoietin administration partially prevents adipose tissue loss in experimental cancer cachexia models

    OpenAIRE

    Penna, Fabio; Busquets, Silvia; Toledo, Miriam; Pin, Fabrizio; Massa, David; López-Soriano, Francisco J.; Costelli, Paola; Argilés, Josep M.

    2013-01-01

    Cancer-associated cachexia is characterized, among other symptoms, by a dramatic loss of both muscle and fat. In addition, the cachectic syndrome is often associated with anemia. The object of the present investigation was to assess the effects of erythropoietin (EPO) treatment on experimental cancer cachexia models. The results clearly show that, in addition to the improvement of the hematocrit, EPO treatment promoted a partial preservation of adipose tissue while exerting negligible effects...

  1. Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice

    OpenAIRE

    Sang-Oh Park; Byung-Sung Park; Ga-Yeong Noh

    2015-01-01

    The Natural Plant Extracts (NPE), produced by mixing seven natural plant extracts including sweet flag, contains asacurin 100 as its main ingredient and shows improvement in skin, but no hair growth effect has been reported. This study was conducted to evaluate the effects of NPE on mouse hair loss prevention and hair growth promotion and to determine the mechanism of action of NPE. Thirty male C57BL/6 mice were randomized into three treatment groups of 10 mice each: Control group (saline), N...

  2. Physical therapy resources in prevention of bone mineral density loss in patients with spinal cord injury – literature review

    Directory of Open Access Journals (Sweden)

    Daniele Rodrigues

    2004-03-01

    Full Text Available This paper comprises a literature review on physical therapytreatment on prevention, stabilization or slowing down the processof bone mineral density loss in patients with spinal cord injury.There are few studies in the literature on the efficiency of physicaltherapy treatment for bone demineralization. There are reports offour types of treatment for demineralization: functional electricalstimulation, functional electrical stimulation-induced cycling,standing and ambulation. These treatments are rather questionableand controversial in relation to efficacy and there is no consensuson their methodologies.

  3. Systemic immunotherapy delays photoreceptor cell loss and prevents vascular pathology in Royal College of Surgeons rats

    OpenAIRE

    Adamus, Grazyna; Wang, Shaomei; Kyger, Madison; Worley, Aneta; Lu, Bin; Burrows, Gregory G.

    2012-01-01

    Purpose Degenerative retinopathies, including retinitis pigmentosa, age-related retinal degeneration, autoimmune retinopathy, and related diseases affect millions of people around the world. Currently, there is no effective treatment for most of those diseases. We investigated systemic recombinant T-cell receptor ligand (RTL) immunotherapy for preventing retinal degeneration and vascular damage in the Royal College of Surgeons (RCS) rat model of retinal degeneration. Methods RCS rats were tre...

  4. Caffeine Treatment Prevented from Weight Regain after Calorie Shifting Diet Induced Weight Loss

    OpenAIRE

    Davoodi, Sayed Hossein; Hajimiresmaiel, Seyed Javad; Ajami, Marjan; Mohseni-Bandpei, Anoushiravan; Ayatollahi, Seyyed Abdulmajid; Dowlatshahi, Kamran; Javedan, Gholamali; Pazoki-Toroudi, Hamidreza

    2014-01-01

    Low calorie diets are always difficult for obese subjects to follow and lead to metabolic and behavioral adaptation. Therefore, we evaluated the effect of caffeine treatment with calorie shifting diet (CSD) on weight loss. Female subjects (n=60; BMI≥25) completed 4-weeks control diet, 6-weeks CSD (3 repeated phases; each 2-weeks) and 4-weeks follow-up diet, with or without caffeine treatment (5 mg/Kg/day). The first 11 days of each phase included calorie restriction with four meals every day ...

  5. ITI implants with overdentures: a prevention of bone loss in edentulous mandibles?

    DEFF Research Database (Denmark)

    von Wowern, N; Harder, F; Hjørting-Hansen, E;

    1990-01-01

    Changes in the bone mineral content (BMC) of edentulous mandibles with osseointegrated ITI implants supporting overdentures were measured in vivo by dual-photon absorptiometry. The BMC measurements were performed 3 weeks postoperatively and at the 2-year follow-up visit. Measurements were made...... in the ITI site (anteriorly), the premolar region just behind the fixtures, and the standard site of the mandible for obtaining reference values of the age-related MBC loss. The increased function of the mandible after this treatment seems to cause a load-related bone formation that minimizes, or in some...

  6. Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro

    Directory of Open Access Journals (Sweden)

    Mélanie Spilmont

    2015-11-01

    Full Text Available The nutritional benefits of pomegranate have attracted great scientific interest. The pomegranate, including the pomegranate peel, has been used worldwide for many years as a fruit with medicinal activity, mostly antioxidant properties. Among chronic diseases, osteoporosis, which is associated with bone remodelling impairment leading to progressive bone loss, could eventually benefit from antioxidant compounds because of the involvement of oxidative stress in the pathogenesis of osteopenia. In this study, with in vivo and ex vivo experiments, we investigated whether the consumption of pomegranate peel extract (PGPE could limit the process of osteopenia. We demonstrated that in ovariectomized (OVX C57BL/6J mice, PGPE consumption was able to significantly prevent the decrease in bone mineral density (−31.9%; p < 0.001 vs. OVX mice and bone microarchitecture impairment. Moreover, the exposure of RAW264.7 cells to serum harvested from mice that had been given a PGPE-enriched diet elicited reduced osteoclast differentiation and bone resorption, as shown by the inhibition of the major osteoclast markers. In addition, PGPE appeared to substantially stimulate osteoblastic MC3T3-E1 alkaline phosphatase (ALP activity at day 7, mineralization at day 21 and the transcription level of osteogenic markers. PGPE may be effective in preventing the bone loss associated with ovariectomy in mice, and offers a promising alternative for the nutritional management of this disease.

  7. Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss

    Directory of Open Access Journals (Sweden)

    Anne-Priscille Trouvin

    2010-11-01

    Full Text Available Anne-Priscille Trouvin, Vincent GoëbDepartment of Rheumatology, Rouen University Hospital, Rouen, FranceAbstract: Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG and receptor activator for nuclear factor-κB (RANK ligand. The signaling pathway OPG/RANK/RANKL is key to regulation for maintaining the balance between the activity of osteoblasts and osteoclasts in order to prevent bone loss and ensure a normal bone turnover. In this review, the RANK/RANKL/OPG pathway is described. The multiple interactions of various factors (hormones, cytokines, growth factors, and vitamins with the OPG/RANK/RANKL pathway are also commented on. Finally, the effects of denosumab, a human monoclonal antibody that binds to RANKL and thereby inhibits the activation of osteoclasts, and of strontium ranelate are also described. Indeed, these two new drugs afford appreciable assistance in daily care practice, helping to prevent bone loss in patients with osteoporosis.Keywords: osteoprotegerin, OPG, RANK, RANKL, denosumab, strontium ranelate, osteoporosis

  8. Personal listening devices and the prevention of noise induced hearing loss in children: The cheers for ears pilot program

    Directory of Open Access Journals (Sweden)

    Dunay Schmulian Taljaard

    2013-01-01

    Full Text Available To determine whether the Cheers for Ears Program on noise induced hearing loss prevention was effective in improving current knowledge of noise impact of personal listening devices on hearing, and in changing self-reported listening behavior of primary school students aged between 9 years and 13 years. A survey study was implemented at participating primary schools. Schools represented various levels of socio-economic status. Informed consent (parents and teachers and informed assent (pupils were obtained. All pupils participated in two interactive sessions (the second 6 weeks after first and only those who provided assent and consent were surveyed at three points during the study: Prior to the first session (baseline, directly post-session and at 3 months post-session. A total of 318 pupils were surveyed. The median age of the participants was 11 years (nearly 50% of the total cohort. Significant changes are reported in their knowledge about hearing and in listening behavior of the participants as measured by pre- and post-measurement. The changes in behaviors were stable and sustained at 3 months post-intervention survey point and the success of the program can be attributed to the multimodal interactive nature of the sessions, the spacing of the sessions and the survey points. Wide-ranging support from schools and departments also played a role. The pilot Cheers for Ears Program is effective in increasing knowledge on the harmful effects of noise and therefore, it may prevent future noise-induced hearing loss.

  9. Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice

    Directory of Open Access Journals (Sweden)

    Sang-Oh Park

    2015-01-01

    Full Text Available The Natural Plant Extracts (NPE, produced by mixing seven natural plant extracts including sweet flag, contains asacurin 100 as its main ingredient and shows improvement in skin, but no hair growth effect has been reported. This study was conducted to evaluate the effects of NPE on mouse hair loss prevention and hair growth promotion and to determine the mechanism of action of NPE. Thirty male C57BL/6 mice were randomized into three treatment groups of 10 mice each: Control group (saline, NPE and minoxidil 5% application. For the NPE application group, the first hair growth was observed on day 9 and the density, length and thickness of their hair were significantly higher than those of the control group. Compared to the control group, the anagen hair growth in the C57BL/6 mice of the NPE application group was significantly stimulated. Compared to the control group, the expression of VEGF and KGF mRNA was up-regulated in the NPE and minoxidil 5% application groups, but the expression of TGF-β1 mRNA was down regulated on the contrary. This result suggests that NPE promotes hair growth while inducing anagen hair growth in animals through genetic regulation while, simultaneously preventing hair loss.

  10. TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

    Directory of Open Access Journals (Sweden)

    Jeanne M McCaffery

    Full Text Available TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI, and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses.We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin processing during 2.5-years of follow-up participants (N = 2,994 from the Diabetes Prevention Program (DPP, a randomized controlled trial designed to prevent or delay diabetes in high-risk adults.We observed no difference in the degree of weight loss by rs7903146 genotypes. However, the T allele (conferring higher risk of diabetes at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001, higher baseline proinsulin:insulin ratio (p<0.0001 and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003. Effects were comparable across treatment arms.The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin:insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.

  11. Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model

    International Nuclear Information System (INIS)

    Highlights: •A GST-FSH fusion protein was successfully expressed in E. coli. •Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. •Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. •FSH immunization can prevent bone loss in a rat osteoporosis model. -- Abstract: Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally. Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is used widely in the clinic because it has been generally accepted that postmenopausal osteoporosis is caused by estrogen deficiency. However, hypogonadal α and β estrogen receptor null mice were only mildly osteopenic, and mice with either receptor deleted had normal bone mass, indicating that estrogen may not be the only mediator that induces osteoporosis. Recently, follicle-stimulating hormone (FSH), the serum concentration of which increases from the very beginning of menopause, has been found to play a key role in postmenopausal osteoporosis by promoting osteoclastogenesis. In this article, we confirmed that exogenous FSH can enhance osteoclast differentiation in vitro and that this effect can be neutralized by either an anti-FSH monoclonal antibody or anti-FSH polyclonal sera raised by immunizing animals with a recombinant GST-FSHβ fusion protein antigen. Moreover, immunizing ovariectomized rats with the GST-FSHβ antigen does significantly prevent trabecular bone loss and thereby enhance the bone strength, indicating that a FSH-based vaccine may be a promising therapeutic strategy to slow down bone loss in postmenopausal women

  12. Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Wenxin; Yan, Xingrong; Du, Huicong; Cui, Jihong; Li, Liwen, E-mail: liven@nwu.edu.cn; Chen, Fulin, E-mail: chenfl@nwu.edu.cn

    2013-05-03

    Highlights: •A GST-FSH fusion protein was successfully expressed in E. coli. •Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. •Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. •FSH immunization can prevent bone loss in a rat osteoporosis model. -- Abstract: Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally. Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is used widely in the clinic because it has been generally accepted that postmenopausal osteoporosis is caused by estrogen deficiency. However, hypogonadal α and β estrogen receptor null mice were only mildly osteopenic, and mice with either receptor deleted had normal bone mass, indicating that estrogen may not be the only mediator that induces osteoporosis. Recently, follicle-stimulating hormone (FSH), the serum concentration of which increases from the very beginning of menopause, has been found to play a key role in postmenopausal osteoporosis by promoting osteoclastogenesis. In this article, we confirmed that exogenous FSH can enhance osteoclast differentiation in vitro and that this effect can be neutralized by either an anti-FSH monoclonal antibody or anti-FSH polyclonal sera raised by immunizing animals with a recombinant GST-FSHβ fusion protein antigen. Moreover, immunizing ovariectomized rats with the GST-FSHβ antigen does significantly prevent trabecular bone loss and thereby enhance the bone strength, indicating that a FSH-based vaccine may be a promising therapeutic strategy to slow down bone loss in postmenopausal women.

  13. Preventive measures to prevent loss to follow-up in highly active antiretroviral therapy (HAART): implementing a strategy in Ziguinchor (Casamance, Senegal) in 2014.

    Science.gov (United States)

    Randé, H; Rouffy, D

    2016-05-01

    Since 2010, the Pharmacie et Aide Humanitaire (PAH) in Casamance (Senegal) has been maintaining a software package (Tacojo) that allows monthly monitoring of the distribution of treatment to every patient with HIV infection receiving highly active antiretroviral therapy (HAART). We used this program to set up measures to prevent the loss to follow-up of patients receiving HAART. Our involvement focused on two main areas. First, each patient is routinely contacted after inclusion, to help us to understand the patient's experience of the disease and the treatment. This process aims to improve adherence to the treatment. Then, all patients who miss an appointment are routinely contacted by telephone within seven days of that appointment. The goal is to understand the reasons for the absence and to encourage patients to continue their treatment. Despite the lack of distance due to the relative newness of this program, these preventive measures have shown hopeful results (80% of the patients came back after a call). It would be interesting to apply it in a sustainable manner and in more medical facilities. PMID:27412981

  14. Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma

    Science.gov (United States)

    Madeira, Maria H.; Ortin-Martinez, Arturo; Nadal-Nícolas, Francisco; Ambrósio, António F.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Santiago, Ana Raquel

    2016-01-01

    Glaucoma is the second leading cause of blindness worldwide, being characterized by progressive optic nerve damage and loss of retinal ganglion cells (RGCs), accompanied by increased inflammatory response involving retinal microglial cells. The etiology of glaucoma is still unknown, and despite elevated intraocular pressure (IOP) being a major risk factor, the exact mechanisms responsible for RGC degeneration remain unknown. Caffeine, which is an antagonist of adenosine receptors, is the most widely consumed psychoactive drug in the world. Several evidences suggest that caffeine can attenuate the neuroinflammatory responses and afford protection upon central nervous system (CNS) injury. We took advantage of a well characterized animal model of glaucoma to investigate whether caffeine administration controls neuroinflammation and elicits neuroprotection. Caffeine or water were administered ad libitum and ocular hypertension (OHT) was induced by laser photocoagulation of the limbal veins in Sprague Dawley rats. Herein, we show that caffeine is able to partially decrease the IOP in ocular hypertensive animals. More importantly, we found that drinking caffeine prevented retinal microglia-mediated neuroinflammatory response and attenuated the loss of RGCs in animals with ocular hypertension (OHT). This study opens the possibility that caffeine or adenosine receptor antagonists might be a therapeutic option to manage RGC loss in glaucoma. PMID:27270337

  15. Preventive Effects of Flaxseed and Sesame Oil on Bone Loss in Ovariectomized Rats

    Directory of Open Access Journals (Sweden)

    S. Boulbaroud

    2008-01-01

    Full Text Available A study was designed to examine the effects of dietary flaxseed oil (FO and sesame oil (SO which are rich successively in n-3 and (n-9 and n-6 on biochemical parameters and histological status of bone. Sixty-four 90-day-old female wistar rats were randomly assigned to 6 groups: sham-operated rat (sham+ control diets, ovariectomized rat (OVX+ control diets, OVX+ 7% FO, OVX+ 7% SO, OVX+ 10% FO, OVX+ 10% SO. After 4 weeks of treatments, rats were euthanized; blood and tissues were collected for analyses. Markers of bone formation which is alkaline phosphatase activity and markers of bone resorption which is tartrate resistant acid phosphatase activity were measured. Present results showed that OVX increased significantly ALP and TRAP activity and the examination of bone tissue showed disruptive and lytic bone trabeculae. Animals fed 10% FO and 10% SO of fat reduced these parameters and improved bone microarchitecture. Whereas, there was no improvement in biochemical and histological states in OVX rats that received 7% of PUFAs successively provided from FO and SO diets. In conclusion, our results are encouraging because they suggest that PUFAs intake may help to prevent osteoporosis associated with estrogens deficiency. However, further studies are needed to determine the mechanism by which a diet rich in n-3 or lignans modulate bone tissue.

  16. Internal hydraulic redistribution prevents the loss of root conductivity during drought.

    Science.gov (United States)

    Prieto, Iván; Ryel, Ronald J

    2014-01-01

    Shrubs of the Great Basin desert in Utah are subjected to a prolonged summer drought with the potential consequence of reduced water transport capability of the xylem due to drought-induced cavitation. Hydraulic redistribution (HR) is the passive movement of water from deep to shallow soil through plant roots. Hydraulic redistribution can increase water availability in shallow soil and ameliorate drought stress, providing better soil and root water status, which could affect shallow root conductivity (Ks) and native root embolism. We tested this hypothesis in an Artemisia tridentata Nutt. mono-specific stand grown in a common garden in Utah. We enhanced HR artificially by applying a once a week deep-irrigation treatment increasing the water potential gradient between deep and shallow soil layers. Plants that were deep-watered had less negative water potentials and greater stomatal conductance and transpiration rates than non-watered control plants. After irrigation with labeled water (δD), xylem water in stems and shallow roots of watered shrubs was enriched with respect to control shrubs, a clear indication of deep water uptake and HR. Shallow root conductivity was threefold greater and shrubs experienced lower native embolism when deep-watered. We found clear evidence of water transfer between deep and shallow roots through internal HR that delayed depletion of shallow soil water content, maintained Ks and prevented root embolism. Overall, our results show a positive effect of HR on root water transport capacity in otherwise dry soil, with important implications for plant water status. PMID:24436338

  17. Prevention of ductility loss in hydrogen-charged steel by gamma-ray irradiation

    International Nuclear Information System (INIS)

    Hydrogen is known as a constituent which degrades the mechanical properties of metals and alloys, particularly their ductility. The degradation of mechanical properties, called hydrogen embrittlement, is a serious problem in metals and alloys under a hydrogen environment, e.g., pickling, welding, plating, etc. Although many researches have been made to clarify the nature and the mechanism of hydrogen embrittlement in steels (1), little has been reported on the method of prevention of hydrogen embrittlement except for works by Pressouyre and Bernstein (2,3). They showed that the susceptibility of ferrous alloys to hydrogen embrittlement is reduced by addition of titanium. Recently, we found that hydrogen in stainless steels is outgassed upon exposure to ionizing radiation (4-7). Therefore, hydrogen embrittlement in steels is expected to be influenced by ionizing radiation. This study was undertaken to determine the extent of prevension of hydrogen embrittlement by examining the effect of gammairradiation on the ductility in a low carbon steel electrolytically charged with hydrogen

  18. Olive oil and vitamin D synergistically prevent bone loss in mice.

    Directory of Open Access Journals (Sweden)

    Camille Tagliaferri

    Full Text Available As the Mediterranean diet (and particularly olive oil has been associated with bone health, we investigated the impact of extra virgin oil as a source of polyphenols on bone metabolism. In that purpose sham-operated (SH or ovariectomized (OVX mice were subjected to refined or virgin olive oil. Two supplementary OVX groups were given either refined or virgin olive oil fortified with vitamin D3, to assess the possible synergistic effects with another liposoluble nutrient. After 30 days of exposure, bone mineral density and gene expression were evaluated. Consistent with previous data, ovariectomy was associated with increased bone turnover and led to impaired bone mass and micro-architecture. The expression of oxidative stress markers were enhanced as well. Virgin olive oil fortified with vitamin D3 prevented such changes in terms of both bone remodeling and bone mineral density. The expression of inflammation and oxidative stress mRNA was also lower in this group. Overall, our data suggest a protective impact of virgin olive oil as a source of polyphenols in addition to vitamin D3 on bone metabolism through improvement of oxidative stress and inflammation.

  19. Analysis of an unmitigated large break loss of coolant accident (LBLOCA) with the non-mechanistic failure of passive cooling for the APT Spallation Target

    International Nuclear Information System (INIS)

    In order to support the Programmatic Environmental Impact Statement, an accident analysis has been performed for the Accelerator Production of Tritium (APT) Spallation-Induced Lithium Conversion (SILC) Source. This report presents a lumped-parameter analysis that predicts the thermal response of the source to a large-break LOCA. The accident scenario assumes the break to occur in the cold leg outside the source basin and the pipe break is immediately followed by the tripping of the proton beam and the activation of the source-basin flood system. The calculations were performed for a ''beyond-design-basis event'' which further assumes the failure of all other active cooling systems, and the failure to establish natural circulation in the unbroken loop. Calculations show that the source rods remain flooded in heavy water until 44 hours after the LOCA. At this time, the source rods begin to be uncovered and at 48 hours into the accident the source rods are completely boiled dry. The average source temperature reaches a maximum value of 303 C at 57 hours. Thereafter, the source rods begin to cool since the heat transfer to the basin water is sufficient to remove all the decay heat from the source. It is estimated that by this time a maximum of 27% of the lead inventory (6,558 kg) in the source rods can be expected to melt. This molten material, assuming that it can get out of the aluminum cladding, will fall to the D2O-filled bottom header, quench rapidly, and remain in a coolable state

  20. Aircraft Loss-of-Control Accident Prevention: Switching Control of the GTM Aircraft with Elevator Jam Failures

    Science.gov (United States)

    Chang, Bor-Chin; Kwatny, Harry G.; Belcastro, Christine; Belcastro, Celeste

    2008-01-01

    Switching control, servomechanism, and H2 control theory are used to provide a practical and easy-to-implement solution for the actuator jam problem. A jammed actuator not only causes a reduction of control authority, but also creates a persistent disturbance with uncertain amplitude. The longitudinal dynamics model of the NASA GTM UAV is employed to demonstrate that a single fixed reconfigured controller design based on the proposed approach is capable of accommodating an elevator jam failure with arbitrary jam position as long as the thrust control has enough control authority. This paper is a first step towards solving a more comprehensive in-flight loss-of-control accident prevention problem that involves multiple actuator failures, structure damages, unanticipated faults, and nonlinear upset regime recovery, etc.

  1. Combat, prevention and optimization of commercial losses of power energy; Combate, prevencao e otimizacao das perdas comerciais da energia eletrica

    Energy Technology Data Exchange (ETDEWEB)

    Penin, Carlos Alexandre de Sousa

    2008-07-01

    The objective of this work is to study the problem of NTL using a wide approach, analyze the experience of dealerships in Brazil and abroad, discuss the best practices for mitigation of those losses and propose improvements in the combat and prevention processes, and the legal procedures for recovery of incomes, leaning on a careful regulatory context. This study draws attention to Brazil's socioeconomic diversity, comparing it to various international examples, and intends to identify the most relevant aspects that must be considered on the theme, discussing procedures and methodologies for the equation of the amount of resources to be applied by distributing companies to achieve the appropriate reduction of NTL. (author)

  2. String breaking

    CERN Document Server

    Bali, G S; Lippert, T; Neff, H; Prkacin, Z; Schilling, K; Bali, Gunnar S; Dussel, Thomas; Lippert, Thomas; Neff, Hartmut; Prkacin, Zdravko; Schilling, Klaus

    2006-01-01

    We numerically investigate the transition of the static quark-antiquark string into a static-light meson-antimeson system. Improving noise reduction techniques, we are able to resolve the signature of string breaking dynamics for Nf=2 lattice QCD at zero temperature. We discuss the lattice techniques used and present results on energy levels and mixing angle of the static two-state system. We visualize the action density distribution in the region of string breaking as a function of the static colour source-antisource separation. The results can be related to properties of quarkonium systems.

  3. Sealed Radioactive Sources. Information, Resources, and Advice for Key Groups about Preventing the Loss of Control over Sealed Radioactive Sources

    International Nuclear Information System (INIS)

    Among its many activities to improve the safety and security of sealed sources, the IAEA has been investigating the root causes of major accidents and incidents since the 1980's and publishes findings so that others can learn from them. There are growing concerns today about the possibility that an improperly stored source could be stolen and used for malicious purposes. To improve both safety and security, information needs to be in the hands of those whose actions and decisions can prevent a source from being lost or stolen in the first place. The IAEA developed this booklet to help improve communication with key groups about hazards that may result from the loss of control over sealed radioactive sources and measures that should be implemented to prevent such loss of control. Many people may benefit from the information contained in this booklet, particularly those working with sources and those likely to be involved if control over a source is lost; especially: officials in government agencies, first responders, medical users, industrial users and the metal recycling industry. The general public may also benefit from an understanding of the fundamentals of radiation safety. This booklet is comprised of several stand-alone chapters intended to communicate with these key groups. Various accidents that are described and information that is provided are relevant to more than one key group and therefore, some information is repeated throughout the booklet. This booklet seeks to raise awareness of the importance of the safety and security of sealed radioactive sources. However, it is not intended to be a comprehensive 'how to' guide for implementing safety and security measures for sealed radioactive sources. For more information on these measures, readers are encouraged to consult the key IAEA safety and security-related publications identified in this booklet

  4. Dosing study on the effectiveness of salicylate/N-acetylcysteine for prevention of noise-induced hearing loss

    Directory of Open Access Journals (Sweden)

    John Coleman

    2010-01-01

    Full Text Available The efficacy of three different doses of sodium salicylate (SAL in combination with one dose of N-acetylcysteine (NAC to prevent noise-induced hearing loss was studied in chinchillas. After obtaining baseline-hearing thresholds, the chinchillas were randomly assigned to one of four treatment groups: three sets were injected intraperitoneally with 325 mg/kg NAC combined with 25, 50, or 75 mg/kg SAL, and a separate control group was injected with an equal volume of saline. Animals were injected twice daily for 2 days prior to and 1 hour before the noise exposure (6 hours to a 105-dB Standard Pressure Level octave band noise centered at 4 kHz. Immediate post-noise hearing thresholds were obtained followed by post-noise treatments at 1 hour then twice-daily for 2 days. Hearing tests continued at 1, 2, and 3 weeks post-noise, and immediately after the last hearing test, animals′ cochleae were stained for hair cell counts. All the groups showed hearing improvement until week 2. However, at week 3, saline treated animals demonstrated a 17-33 dB SPL permanent threshold shift (PTS across the test frequencies. Hearing loss was lowest in the 50 SAL/325 NAC mg/kg group (all frequencies, P < 0.001, and although PTS was reduced in the 25 and 75 mg/kg SAL dosage groups compared to the saline group, only the 75 mg/kg SAL group was significantly different at all but 2 kHz frequency. Coupled with the hearing loss, outer hair cell (OHC loss was maximal in the 4-8 kHz cochlear region of saline treated animals. However, there was a substantial reduction in the mean OHC loss of the NAC plus 50 or 75 mg/kg (but not the 25 mg/kg SAL groups. These findings suggest that SAL in combination with NAC is effective in reducing noise damage to the cochlea, but SAL has a relatively narrow therapeutic dosing window.

  5. Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.

    Science.gov (United States)

    Irwin, Jacob A; Erisir, Alev; Kwon, Inchan

    2016-01-01

    Reducing amyloid-β (Aβ) accumulation is a promising strategy for developing Alzheimer's Disease (AD) therapeutics. We recently reported that a triphenylmethane food dye analog, Brilliant Blue G (BBG), is a dose-dependent modulator of in vitro amyloid-β aggregation and cytotoxicity in cell-based assays. Following up on this recent work, we sought to further evaluate this novel modulator in a therapeutically-relevant AD transgenic mouse model. BBG was orally administered to APPSwDI/NOS2-/- mice for three months in order to assess its biocompatibility, its permeability across the blood-brain barrier, and its efficacy at rescuing AD pathology. The results showed that BBG was well-tolerated, caused no significant weight change/unusual behavior, and was able to significantly cross the AD blood-brain barrier in APPSwDI/NOS2-/- mice. Immunohistochemical and electron microscopic analysis of the brain sections revealed that BBG was able to significantly prevent neuronal loss and reduce intracellular APP/Aβ in hippocampal neurons. This is the first report of 1) the effect of Brilliant Blue G on neuronal loss in a transgenic animal model of AD, 2) oral administration of BBG to affect a protein conformation/aggregation disease, and 3) electron microscopic ultrastructural analysis of AD pathology in APPSwDI/NOS2-/- mice. PMID:26852943

  6. Noise-induced hearing loss in agriculture: Creating partnerships to overcome barriers and educate the community on prevention

    Directory of Open Access Journals (Sweden)

    Janet J Ehlers

    2011-01-01

    Full Text Available Noise-induced hearing loss (NIHL is a common and preventable injury for farmers. Farmers are frequently exposed to excessive noise, ranking among the top three occupations and industries with the highest risk for hearing loss. Use of hearing protection among farmers is not common. Although the age when NIHL begins among farmers is unknown, its prevalence is higher among male adolescents who live and work on farms. The purpose of this paper is to describe how NIOSH created partnerships to promote hearing conservation for this hard-to-reach population. Partnerships included organizations and individuals who were trusted sources of information for the target population, young farmers 14-35 years of age and their families, and those who had linkages in rural communities. NIOSH engaged partners through exhibits and train-the-trainer workshops at state or national conventions. NIOSH workshops included basic information on NIHL as well as information on free or low-lost resources that participants could use in training others at schools and community events. People with hearing conservation expertise have an important role and many opportunities to improve the knowledge and implementation of hearing conservation among those in agriculture.

  7. Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease.

    Directory of Open Access Journals (Sweden)

    Marielza Andrade Nunes

    Full Text Available The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer's disease (AD patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd20Lms/2J and their non-transgenic litter mate genetic controls were treated with lithium carbonate (0.25mg/Kg/day in drinking water for 16 or 8 months starting at two and ten months of age, respectively [corrected]. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer's disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained.

  8. Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease.

    Science.gov (United States)

    Nunes, Marielza Andrade; Schöwe, Natalia Mendes; Monteiro-Silva, Karla Cristina; Baraldi-Tornisielo, Ticiana; Souza, Suzzanna Ingryd Gonçalves; Balthazar, Janaina; Albuquerque, Marilia Silva; Caetano, Ariadiny Lima; Viel, Tania Araujo; Buck, Hudson Sousa

    2015-01-01

    The use of lithium is well established in bipolar disorders and the benefits are being demonstrated in neurodegenerative disorders. Recently, our group showed that treatment with microdose lithium stabilized the cognitive deficits observed in Alzheimer's disease (AD) patients. In order to verify the lithium microdose potential in preventing the disease development, the aim of this work was to verify the effects of chronic treatment with microdose lithium given before and after the appearance of symptoms in a mouse model of a disease similar to AD. Transgenic mice (Cg-Tg(PDGFB-APPSwInd)20Lms/2J) and their non-transgenic litter mate genetic controls were treated with lithium carbonate (0.25mg/Kg/day in drinking water) for 16 or 8 months starting at two and ten months of age, respectively [corrected]. Similar groups were treated with water. At the end of treatments, both lithium treated transgenic groups and non-transgenic mice showed no memory disruption, different from what was observed in the water treated transgenic group. Transgenic mice treated with lithium since two months of age showed decreased number of senile plaques, no neuronal loss in cortex and hippocampus and increased BDNF density in cortex, when compared to non-treated transgenic mice. It is suitable to conclude that these data support the use of microdose lithium in the prevention and treatment of Alzheimer's disease, once the neurohistopathological characteristics of the disease were modified and the memory of transgenic animals was maintained. PMID:26605788

  9. Supersymmetry breaking

    Indian Academy of Sciences (India)

    Emilian Dudas

    2009-01-01

    We review the various mechanisms of supersymmetry breaking and its trans-mission to the observable sector. We argue that hybrid models where gauge dominates over gravity mediation, but gravity provides the main contributions to the Higgs sector masses and the neutralino mass, are able to combine the advantages and reduce the disadvantages of the two transmission mechanisms.

  10. Prevention

    DEFF Research Database (Denmark)

    Halken, S; Høst, A

    2001-01-01

    , breastfeeding should be encouraged for 4-6 months. In high-risk infants a documented extensively hydrolysed formula is recommended if exclusive breastfeeding is not possible for the first 4 months of life. There is no evidence for preventive dietary intervention neither during pregnancy nor lactation....... Preventive dietary restrictions after the age of 4-6 months are not scientifically documented....

  11. Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.

    Directory of Open Access Journals (Sweden)

    Catriona Paul

    Full Text Available BACKGROUND: Infertility affects approximately 20% of couples in Europe and in 50% of cases the problem lies with the male partner. The impact of damaged DNA originating in the male germ line on infertility is poorly understood but may increase miscarriage. Mouse models allow us to investigate how deficiencies in DNA repair/damage response pathways impact on formation and function of male germ cells. We have investigated mice with deletions of ERCC1 (excision repair cross-complementing gene 1, MSH2 (MutS homolog 2, involved in mismatch repair pathway, and p53 (tumour suppressor gene implicated in elimination of germ cells with DNA damage. PRINCIPAL FINDINGS: We demonstrate for the first time that depletion of ERCC1 or p53 from germ cells results in an increased incidence of unrepaired DNA breaks in pachytene spermatocytes and increased numbers of caspase-3 positive (apoptotic germ cells. Sertoli cell-only tubules were detected in testes from mice lacking expression of ERCC1 or MSH2 but not p53. The number of sperm recovered from epididymes was significantly reduced in mice lacking testicular ERCC1 and 40% of sperm contained DNA breaks whereas the numbers of sperm were not different to controls in adult Msh2 -/- or p53 -/- mice nor did they have significantly compromised DNA. CONCLUSIONS: These data have demonstrated that deletion of Ercc1, Msh2 and p53 can have differential but overlapping affects on germ cell function and sperm production. These findings increase our understanding of the ways in which gene mutations can have an impact on male fertility.

  12. The Break

    DEFF Research Database (Denmark)

    Strand, Anete Mikkala Camille

    2016-01-01

    The chapter elaborates on how to deal with one of the major challenges facing organizations worldwide; Stress. The Break enacts a quantum approach to meet the challenges by proposing a combination of three different quantum storytelling technologies; protreptic mentoring, walking and material sto...... provider and witness to your elaborations. It’s really that simple! The chapter concludes towards a set of Dogmas for future reference in addressing these challenges in this manner....

  13. Analysis of small-break loss-of-coolant accident test 9.1b at BETHSY facility with TRACE and RELAP5

    International Nuclear Information System (INIS)

    Recently, several advanced computational tools for simulating reactor system behavior during real and hypothetical transient scenarios were developed. The TRAC/RELAP Advanced Computational Engine (TRACE) is the latest in a series of advanced, best-estimate reactor systems codes developed by the U.S. Nuclear Regulatory Commission. The purpose of the present study was to assess the accuracy of the TRACE calculation of BETHSY 9.1b test comparing to RELAP5 calculation. The TRACE input deck was semi-converted (using SNAP and manual corrections) from the RELAP5 input deck and then some adaptations were needed too. The TRACE V5.0 Patch 1 and RELAP5/MOD3.3 Patch 3 were used for calculations. The BETHSY 9.1b test (International Standard Problem no. 27 or ISP-27) was 5.08 cm equivalent diameter cold leg break without high pressure safety injection and with delayed ultimate procedure. In general, the TRACE code calculation is in good agreement with the BETHSY 9.1b test. The calculation results are as good as or better than the RELAP5 calculated results until low pressure injection period. It should be mentioned that the RELAP5 developed animation model was of great help in investigating the calculated physical phenomena and preparing the preliminary TRACE analysis. (authors)

  14. Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Li-Juan Zhang

    Full Text Available Human albumin has recently been demonstrated to protect brain neurons from injury in rat ischemic brain. However, there is no information available about whether human albumin can prevent loss of tyrosine hydroxylase (TH expression of dopaminergic (DA neurons induced by 6-hydroxydopamine (6-OHDA toxicity that is most commonly used to create a rat model of Parkinson's disease (PD. In the present study, two microliters of 1.25% human albumin were stereotaxically injected into the right striatum of rats one day before or 7 days after the 6-OHDA lesion in the same side. D-Amphetamine-induced rotational asymmetry was measured 7 days, 3 and 10 weeks after 6-OHDA lesion. We observed that intrastriatal administration of human albumin significantly reduced the degree of rotational asymmetry. The number of TH-immunoreactive neurons present in the substantia nigra was greater in 6-OHDA lesioned rats following human albumin-treatment than non-human albumin treatment. TH-immunoreactivity in the 6-OHDA-lesioned striatum was also significantly increased in the human albumin-treated rats. To examine the mechanisms underlying the effects of human albumin, we challenged PC12 cells with 6-OHDA as an in vitro model of PD. Incubation with human albumin prevented 6-OHDA-induced reduction of cell viability in PC12 cell cultures, as measured by MTT assay. Furthermore, human albumin reduced 6-OHDA-induced formation of reactive oxygen species (ROS and apoptosis in cultured PC12 cells, as assessed by flow cytometry. Western blot analysis showed that human albumin inhibited 6-OHDA-induced activation of JNK, c-Jun, ERK, and p38 mitogen-activated protein kinases (MAPK signaling in PC12 cultures challenged with 6-OHDA. Human albumin may protect against 6-OHDA toxicity by influencing MAPK pathway followed by anti-ROS formation and anti-apoptosis.

  15. TEI-3313, a novel prostaglandin A1 derivative, prevents bone loss and enhances bone formation in immobilized male rats.

    Science.gov (United States)

    Ohta, T; Azuma, Y; Kanatani, H; Kiyoki, M; Koshihara, Y

    1995-10-01

    The effect of a novel prostaglandin A1 derivative, TEI-3313, with the chemical structure 5-[(Z,2E)-4,7-dihydroxy-2-heptenyridene]-4-hydroxy- 2-methylthio-4-(4-phenoxybutyl)-2-cyclopentenone, on bone mineral content was investigated. Seven-week-old Sprague-Dawley rats in which the right hindlimbs were immobilized by sciatic nerve dissection received 1, 10, 100 or 500 micrograms of TEI-3313/kg/day, i.p., for 6 weeks. Control animals were operated on but received vehicle only. Bone mineral content of the femur was measured by single-photon absorptiometry, and biochemical parameters were analyzed. Histomorphometric observations were performed on the proximal metaphysial sections of the tibiae. The administration of up to 500 micrograms/kg of TEI-3313 to rats had no effect on body weight or on serum calcium, inorganic phosphorus and 1 alpha,25 dihydroxy vitamin D3 levels. Immobilization decreased the ash content, calcium content and total bone mineral content of the femur compared with nonimmobilization (unoperated femur). With TEI-3313 administration, changes in these parameters in the immobilized femur were prevented almost to the levels of the nonimmobilized femur, in a dose-dependent manner. The enhancement of bone mineral content was remarkable in the midshaft of the femur. TEI-3313 enhanced ash and calcium content and total bone mineral content in nonimmobilized femurs. Microradiograms showed that TEI-3313, unlike pamidronate and 17 beta-estradiol, had little inhibitory effect on trabecular bone resorption in the proximal portion of the tibia. TEI-3313 not only prevented the bone loss induced by immobilization but also increased bone mass in the nonimmobilized femurs without affecting the levels of 1 alpha,25 dihydroxy vitamin D3.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7562584

  16. Break location effects on PWR small break LOCA phenomena

    International Nuclear Information System (INIS)

    The report presents experimental results of a small lower plenum break test of SB-PV-01 conducted at the large-Scale Test Facility (LSTF) of the Rig-of-Safety Assessment (ROSA)-IV program. This test simulates a loss-of-coolant accident (LOCA) caused by instrument tubes break (break area corresponds to 0.5% of the cold leg flow area) in a Westinghouse-type pressurized water reactor (PWR) assuming both manual actuation for all of the high pressure injection (HPI) systems and failure of the auxiliary feedwater systems. The report clarifies long-term system responses, especially the core cooling conditions related to the primary mass inventory. Also it clarifies break location effects on small break LOCA phenomena by comparing other five similar LOCA tests with break locations at cold leg, hot leg, upper head, pressurizer top (TMI-type) and SG U-tubes. It is coucluded that the lower plenum break is the severest on core heatup due to the highest break flow rate and the least primary mass recovery after the ECCS among the six tests. (author)

  17. Prevention of postmenopausal bone loss - effects of alternative administration forms of estrogens, alternative gestagens and calcium addition

    International Nuclear Information System (INIS)

    Calcium metabolism was examined in 133 healthy postmenopausal women every three months during two years of treatment with oral or percutaneous 17β-estradiol combined with different doses of calcium supplementation and/or different gestagens. Bone mineral content measured in the forearm (single photon absorptiometry), in the spine and in the total skeleton (dual photon absorptiometry) was unchanged in all estrogen-treated groups during the two years of treatment, and the responses in the groups with and without calcium supplementation and with different gestagens were not significantly different. Furthermore, the responses were independent of route of administration of the estrogen. Biochemical indices of bone turnover (serum alkaline phosphatase and fasting urinary hydroxyproline/creatinine) decreased highly significantly during estrogen treatment (p<0.001) independent of route of administration of the estrogen, of calcium supplementation, and of gestagen agent. We conclude that estrogen treatment independently of route of administration, prevents postmenopausal bone loss. The gestagen agents used here do not affect calcium metabolism, and calcium supplementation has no additive effect to estrogen therapy. (orig.)

  18. Prevention of postmenopausal bone loss - effects of alternative administration forms of estrogens, alternative gestagens and calcium addition

    Energy Technology Data Exchange (ETDEWEB)

    Riis, B.J.; Christiansen, C.

    1987-02-01

    Calcium metabolism was examined in 133 healthy postmenopausal women every three months during two years of treatment with oral or percutaneous 17..beta..-estradiol combined with different doses of calcium supplementation and/or different gestagens. Bone mineral content measured in the forearm (single photon absorptiometry), in the spine and in the total skeleton (dual photon absorptiometry) was unchanged in all estrogen-treated groups during the two years of treatment, and the responses in the groups with and without calcium supplementation and with different gestagens were not significantly different. Furthermore, the responses were independent of route of administration of the estrogen. Biochemical indices of bone turnover (serum alkaline phosphatase and fasting urinary hydroxyproline/creatinine) decreased highly significantly during estrogen treatment (p<0.001) independent of route of administration of the estrogen, of calcium supplementation, and of gestagen agent. We conclude that estrogen treatment independently of route of administration, prevents postmenopausal bone loss. The gestagen agents used here do not affect calcium metabolism, and calcium supplementation has no additive effect to estrogen therapy.

  19. The bisphosphonate zoledronate prevents vertebral bone loss in mature estrogen-deficient rats as assessed by micro-computed tomography

    Directory of Open Access Journals (Sweden)

    Glatt M.

    2001-01-01

    Full Text Available The effect of long-term treatment with the bisphosphonate zoledronate on vertebral bone architecture was investigated in estrogen-deficient mature rats. 4-month-old rats were ovariectomized and development of cancellous osteopenia was assessed after 1 year. The change of bone architectural parameters was determined with a microtomographic instrument of high resolution. After 1 year of estrogen-deficiency, animals lost 55% of vertebral trabecular bone in comparison to sham operated control animals. Trabecular number (Tb.N and trabecular thickness (Tb.Th were significantly reduced in ovariectomized animals, whereas trabecular separation (Tb.Sp, bone surface to volume fraction (BS/BV and trabecular bone pattern factor (TBPf were significantly increased, indicating a loss of architectural integrity throughout the vertebral body. 3 groups of animals were treated subcutaneously with zoledronate for 1 year with 0.3, 1.5 and 7.5 microgram/kg/week to inhibit osteoclastic bone degradation. Administration started immediately after ovariectomy and treatment dose-dependently prevented the architectural bone deterioration and completely suppressed the effects of estrogen deficiency at the higher doses. The results show that microtomographic determination of static morphometric parameters can be used to quantitate the effects of drugs on vertebral bone architecture in small laboratory animals and that zoledronate is highly effective in this rat model.

  20. Breaking Symmetries

    CERN Document Server

    Peters, Kirstin

    2010-01-01

    A well-known result by Palamidessi tells us that {\\pi}mix (the {\\pi}-calculus with mixed choice) is more expressive than {\\pi}sep (its subset with only separate choice). The proof of this result argues with their different expressive power concerning leader election in symmetric networks. Later on, Gorla of- fered an arguably simpler proof that, instead of leader election in symmetric networks, employed the reducibility of "incestual" processes (mixed choices that include both enabled senders and receivers for the same channel) when running two copies in parallel. In both proofs, the role of breaking (ini- tial) symmetries is more or less apparent. In this paper, we shed more light on this role by re-proving the above result-based on a proper formalization of what it means to break symmetries-without referring to another layer of the distinguishing problem domain of leader election. Both Palamidessi and Gorla rephrased their results by stating that there is no uniform and reason- able encoding from {\\pi}mix i...

  1. The Break

    DEFF Research Database (Denmark)

    Strand, Anete Mikkala Camille; Larsen, Jens

    2015-01-01

    to Explore your Leadership” . ”Time to reflect closer to heaven as we did in the Pyrenees, makes me humble and simplifies the thoughts on how to lead within my own set of values. It´s all about energy”, (Lars Lund Hansen, manager, Novo Nordisk) A few objects; a neckless, a candle, a dragon and five crystal...... terrain break elaborates the terrain of Organizations anno 2015 as a terrain of complexity, streamlining, language-orientation and dis-functionality. The latter in regard to a WHO acknowledged concern for health issues related to work-related stress (Prætorius, 2012) and an ongoing urge for learning...... that language and the social has been granted too much power on the dispense of the bodily, physical and biological – or in short, in dispense of the material. The break To be or not to be poses the theoretical notion of dis-/continuity (Barad, 2007, 2010) from the quantum approach to storytelling (Strand 2012...

  2. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina

    OpenAIRE

    Beltran, William A.; Wen, Rong; Acland, Gregory M.; Aguirre, Gustavo D.

    2007-01-01

    Ciliary neurotrophic factor (CNTF) rescues photoreceptors in several animal models of retinal degeneration and is currently being evaluated as a potential treatment for retinitis pigmentosa in humans. This study was conducted to test whether CNTF prevents photoreceptor cell loss in XLPRA2, an early onset canine model of X-linked retinitis pigmentosa caused by a frameshift mutation in RPGR exon ORF15.

  3. Quantifying reactor safety margins: Application of code scaling, applicability, and uncertainty evaluation methodology to a large-break, loss-of-coolant accident

    International Nuclear Information System (INIS)

    The US Nuclear Regulatory Commission (NRC) has issued a revised rule for loss-of-coolant accident/emergency core cooling system (ECCS) analysis of light water reactors to allow the use of best-estimate computer codes in safety analysis as an option. A key feature of this option requires the licensee to quantify the uncertainty of the calculations and include that uncertainty when comparing the calculated results with acceptance limits provided in 10 CFR Part 50. To support the revised ECCS rule and illustrate its application, the NRC and its contractors and consultants have developed and demonstrated an uncertainty evaluation methodology called code scaling, applicability, and uncertainty (CSAU). The CSAU methodology and an example application described in this report demonstrate that uncertainties in complex phenomena can be quantified. The methodology is structured, traceable, and practical, as is needed in the regulatory arena. The methodology is systematic and comprehensive as it addresses and integrates the scenario, experiments, code, and plant to resolve questions concerned with: (a) code capability to scale-up processes from test facility to full-scale nuclear power plants; (b) code applicability to safety studies of a postulated accident scenario in a specified nuclear power plant; and (c) quantifying uncertainties of calculated results. 127 refs., 55 figs., 40 tabs

  4. Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model.

    Science.gov (United States)

    Arai, Yuki; Aoki, Kazuhiro; Shimizu, Yasuhiro; Tabata, Yasuhiko; Ono, Takashi; Murali, Ramachandran; Mise-Omata, Setsuko; Wakabayashi, Noriyuki

    2016-07-01

    Tooth extraction causes bone resorption of the alveolar bone volume. Although recombinant human bone morphogenetic protein 2 (rhBMP-2) markedly promotes de novo bone formation after tooth extraction, the application of high-dose rhBMP-2 may induce side effects, such as swelling, seroma, and an increased cancer risk. Therefore, reduction of the necessary dose of rhBMP-2 which can still obtain sufficient bone mass is necessary by developing a new osteogenic reagent. Recently, we showed that the systemic administration of OP3-4 peptide, which was originally designed as a bone resorption inhibitor, had osteogenic ability both in vitro and in vivo. This study evaluated the ability of the local application of OP3-4 peptide to promote bone formation in a murine tooth extraction model with a very low-dose of BMP. The mandibular incisor was extracted from 10-week-old C57BL6/J male mice and a gelatin hydrogel containing rhBMP-2 with or without OP3-4 peptide (BMP/OP3-4) was applied to the socket of the incisor. Bone formation inside the socket was examined radiologically and histologically at 21 days after the extraction. The BMP/OP3-4-group showed significant bone formation inside the mandibular extraction socket compared to the gelatin-hydrogel-carrier-control group or rhBMP-2-applied group. The BMP/OP3-4-applied mice showed a lower reduction of alveolar bone and fewer osteoclast numbers, suggesting that the newly formed bone inside the socket may prevent resorption of the cortical bone around the extraction socket. Our data revealed that OP3-4 peptide promotes BMP-mediated bone formation inside the extraction socket of mandibular bone, resulting in preservation from the loss of alveolar bone. PMID:27118173

  5. Prevention of bone loss by injection of insulin-like growth factor-1 after sciatic neurectomy in rats

    Institute of Scientific and Technical Information of China (English)

    SUN Hai-biao; CHEN Jun-chang

    2013-01-01

    Injection of insulin-like growth factor-1 (IGF-1) can prevent bone loss in sciatic nerve transaction rats.We try to investigate the action mechanism of IGF-1 on bone formation.Methods:A total of 40 adult male Spragne-Dawley rats were divided into two groups (experimental group and control group) with 20 animals in each.Sciatic neurectomy was performed to model disuse osteoporosis in all rats.IGF-1was administered in experimental group with the dose of 100 μg/kg per day for 3 days.Meanwhile,the rats in control group were treated with saline.Bone mineral density was measured by dual-energy X-ray absorptiometry 4 and 6 weeks after neurectomy respectively.Expression of Osterix and Runx2 was determined by reverse transcription-polymerase chain reaction (RT-PCR) assay.Results:There was a significant increase in the bone mineral density of experimental group compared with control group.There was a significant decrease in the level of receptor activator of nuclear factor-κ B-ligand but an increase in the level of osteoprotegerin 4 and 6 weeks after neurectomy in the experimental group compared with control one.The expression of Osterix and Runx2 was up-regulated in the bone marrow of experimental group compared with control group.Conclusion:IGF-1 can increase bone formation by stimulation of osteoblast number and activity,and reduce bone resorption by restriction of differentiation of osteoclast,suggesting that IGF-1 may improve the therapeutic efficacy for disuse osteoporosis.

  6. Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice

    OpenAIRE

    Lebel, Michel; Lavoie, Josée; Gaudreault, Isabelle; Bronsard, Marc; Drouin, Régen

    2003-01-01

    Werner syndrome is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for Werner syndrome encodes a DNA helicase/exonuclease protein. Participation in a replication complex is among the several functions postulated for the WRN protein. The poly(ADP-ribose) polymerase-1 (PARP-1) enzyme, which is known to bind to DNA strand breaks, is also associated with the DNA replication complex. To determine whether Wrn and PARP-1 enzymes act in c...

  7. Case study: Atlantis Systems International - Using KM principles to drive productivity and performance, prevent critical knowledge loss and encourage innovation

    International Nuclear Information System (INIS)

    necessarily produce innovation in the form of new products and services or in the continual improvement of work flows. Innovation at this level requires the creation of a knowledge building culture where the explicit goal for everyone in the organization is to continuously build and contribute new knowledge to the benefit of both the individual and the organization. By 2007, Atlantis revenues had grown by over 200%; the workforce increased from 102 employees to approx 210 employees; retention rates have remained consistent at 3% over a three year period, and the business has expanded its operations into the United States. In addition the company successfully leveraged its knowledge and expertise in training from the aerospace sector to enter the nuclear energy sector. The paper will present a conceptual framework for understanding Knowledge Management as it relates to organizational development, change management and innovation. Using concrete examples over a 3 three period, it will describe how knowledge management strategies applied by Atlantis to increase performance and profitability, encourage growth, accelerate innovation, attract and retain key talent, prevent knowledge loss, can be applied to the address the looming 'Grey Out' of the nuclear energy sector. (author)

  8. Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice

    Science.gov (United States)

    Chronic alcohol consumption results in bone loss through increased bone resorption and decreased bone formation. These effects can be reversed by estradiol (E2) supplementation. Soy diets are suggested to have protective effects on bone loss in men and women, as a result of the presence of soy prote...

  9. Short-term, daily exposure to cold temperature may be an efficient way to prevent muscle atrophy and bone loss in a microgravity environment

    Science.gov (United States)

    Deng, Claudia; Wang, Ping; Zhang, Xiangming; Wang, Ya

    2015-04-01

    Microgravity induces less pressure on muscle/bone, which is a major reason for muscle atrophy as well as bone loss. Currently, physical exercise is the only countermeasure used consistently in the U.S. human space program to counteract the microgravity-induced skeletal muscle atrophy and bone loss. However, the routinely almost daily time commitment is significant and represents a potential risk to the accomplishment of other mission operational tasks. Therefore, development of more efficient exercise programs (with less time) to prevent astronauts from muscle atrophy and bone loss are needed. Consider the two types of muscle contraction: exercising forces muscle contraction and prevents microgravity-induced muscle atrophy/bone loss, which is a voluntary response through the motor nervous system; and cold temperature exposure-induced muscle contraction is an involuntary response through the vegetative nervous system, we formed a new hypothesis. The main purpose of this pilot study was to test our hypothesis that exercise at 4 °C is more efficient than at room temperature to prevent microgravity-induced muscle atrophy/bone loss and, consequently reduces physical exercise time. Twenty mice were divided into two groups with or without daily short-term (10 min × 2, at 12 h interval) cold temperature (4 °C) exposure for 30 days. The whole bodyweight, muscle strength and bone density were measured after terminating the experiments. The results from the one-month pilot study support our hypothesis and suggest that it would be reasonable to use more mice, in a microgravity environment and observe for a longer period to obtain a conclusion. We believe that the results from such a study will help to develop efficient exercise, which will finally benefit astronauts' heath and NASA's missions.

  10. Application of Relap-5 to the analysis of the Doel-2 steam generator tube rupture accident and studies of the Doel 1-2 loss of feedwater and feedwaterline break accidents

    International Nuclear Information System (INIS)

    By bilateral agreement between the US-NRC and TRACTIONEL, the Relap-5/Mod-2 code was obtained and installed on a CYBER-176 in March 1985. The code assessment work performed at TRACTIONEL is based mainly on operating plant data such as start-up and transients and complemented by data from the LOBI test facility. The simulation of the Doel 2 steam generator tube rupture accident by means of the mod-2 version of the code illustrates some important improvements over the mod-1 version such as smaller mass error and better performance while the comparison with plant data still shows some important shortcomings. Inadequate modeling of the heat and mass transfer for condensation and evaporation in stagnant flow conditions is probably responsible for the larger anomalies in the steam generator pressure and water level. The studies of a loss of feedwater and a feedwaterline break accident, using a best-estimate code with conservative initial and boundary conditions and identical nodalisation as the SGTR simulation, illustrates the high efficiency of the auxiliary feedwater system due to sustained thermal coupling between the primary and the secondary system, for low steam generator inventories

  11. A lifestyle program of exercise and weight loss is effective in preventing and treating type 2 diabetes mellitus: Why are programs not more available?

    Science.gov (United States)

    Ades, Philip A

    2015-11-01

    There is substantial evidence that type 2 diabetes mellitus (T2DM) can be prevented in high-risk individuals by a lifestyle program of regular exercise and weight reduction. Additionally, there is emerging evidence that new onset T2DM (insurance companies generally do not provide coverage for behavioral weight loss programs to prevent or treat T2DM. Consequently, physicians caring for individuals with T2DM may find it much easier to start a chronic glucose lowering medication rather than attempting to motivate and support patients through long-term behavior change. The cardiac rehabilitation model of disease management, with a network of over 2000 programs in the U.S., is well suited to deliver medically-supervised lifestyle programs. National organizations such as the American Diabetes Association and the American Association of Cardiovascular and Pulmonary Rehabilitation should support greater availability and use of lifestyle programs for T2DM treatment and prevention. PMID:25818810

  12. Pioglitazone Treatment Increases Survival and Prevents Body Weight Loss in Tumor–Bearing Animals: Possible Anti-Cachectic Effect

    OpenAIRE

    Beluzi, Mércia; Peres, Sidney B.; Henriques, Felipe S.; Rogério A L Sertié; Franco, Felipe O.; Kaltinaitis B Santos; Knobl, Pâmela; Andreotti, Sandra; Shida, Cláudio S.; Neves, Rodrigo X.; Farmer, Stephen R.; Seelaender, Marília; Fábio B Lima; Batista Jr., Miguel L.

    2015-01-01

    Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. The former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglita...

  13. Treadmill exercise prevents GABAergic neuronal loss with suppression of neuronal activation in the pilocarpine-induced epileptic rats

    OpenAIRE

    Lim, Baek-Vin; Shin, Mal-Soon; Lee, Jae-Min; Seo, Jin-Hee

    2015-01-01

    Epilepsy is a common neurological disorder characterized by seizure and loss of neuronal cells by abnormal rhythmic firing of neurons in the brain. In the present study, we investigated the effect of treadmill exercise on gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal activation using pilocarpine-induced epileptic rats. The rats were divided into four groups: control group, control and treadmill exercise group, pilocarpine-induced epilepsy group, and pilocarpine-i...

  14. Symmetry breaking. 2. ed.

    International Nuclear Information System (INIS)

    This new edition of Prof. Strocchi's well received primer on rigorous aspects of symmetry breaking presents a more detailed and thorough discussion of the mechanism of symmetry breaking in classical field theory in relation with the Noether theorem. Moreover, the link between symmetry breaking without massless Goldstone bosons in Coulomb systems and in gauge theories is made more explicit in terms of the delocalized Coulomb dynamics. Furthermore, the chapter on the Higgs mechanism has been significantly expanded with a non-perturbative treatment of the Higgs phenomenon, at the basis of the standard model of particle physics, in the local and in the Coulomb gauges. Last but not least, a subject index has been added and a number of misprints have been corrected. From the reviews of the first edition: The notion of spontaneous symmetry breaking has proven extremely valuable, the problem is that most derivations are perturbative and heuristic. Yet mathematically precise versions do exist, but are not widely known. It is precisely the aim of his book to correct this unbalance. - It is remarkable to see how much material can actually be presented in a rigorous way (incidentally, many of the results presented are due to Strocchi himself), yet this is largely ignored, the original heuristic derivations being, as a rule, more popular. - At each step he strongly emphasizes the physical meaning and motivation of the various notions introduced, a book that fills a conspicuous gap in the literature, and does it rather well. It could also be a good basis for a graduate course in mathematical physics. It can be recommended to physicists as well and, of course, for physics/mathematics libraries. J.-P. Antoine, Physicalia 28/2, 2006 Strocchi's main emphasis is on the fact that the loss of symmetric behaviour requires both the non-symmetric ground states and the infinite extension of the system. It is written in a pleasant style at a level suitable for graduate students in

  15. Availability and Accessibility of Student-Specific Weight Loss Programs and Other Risk Prevention Health Services on College Campuses

    Science.gov (United States)

    Hayes, Sharon; Napolitano, Melissa; Hufnagel, Katrina

    2016-01-01

    Background More than one third of college students who are overweight or obese are in need of weight loss programs tailored to college students. However, the availability and accessibility of these programs is unknown. Objective The aim of this study is to examine the availability and ease of access to weight loss programs for students at 10 universities with the largest undergraduate enrollment. Methods The 10 public universities with the largest student bodies with a mean (SD) undergraduate enrollment of 41,122 (7657) students were examined. The websites of the universities were assessed to determine the availability of weight loss programs. Services for high-risk health needs common to university campuses (ie, alcohol and other drugs, victim services, sexual health, and eating disorders) were searched. Results Of the universities searched, 3 (30%, 3/10) offered weight loss programming, however, none met the predetermined criteria. Comparatively, all schools (100%, 10/10) offered no-cost and continual enrollment programming for the other high-risk health needs. Conclusions There are limited weight loss services available to undergraduate students compared with other university services. Collaboration between existing college health service providers is suggested for the delivery of appropriate programming for overweight and obese undergraduates wanting to lose weight. PMID:27278261

  16. Implant-supported overdentures, a prevention of bone loss in edentulous mandibles? A 5-year follow-up study

    DEFF Research Database (Denmark)

    von Wowern, N; Gotfredsen, K

    2001-01-01

    minimizes the physiologic age-related mandibular BMC loss, 2) this effect seems to be independent of attachment system and 3) mandibular osteoporosis prior to implant treatment may be a risk factor for bone loss around implants. However, this treatment can be recommended also in osteoporotic persons.......The purpose of this study were to analyse 1) the changes in the bone mineral content (BMC) in mandibles with implant-supported overdentures when compared with the physiologic age-related mandibular BMC loss, 2) whether the BMC changes were different in groups without or with a bar connecting the...... in half of the patients. BMC measurements were performed in vivo by dual-photon scanner at baseline, just after attachment insertion, at 2-year and 5-year visits. Mandibular osteoporosis was estimated by comparing baseline BMC values with normal mandibular BMC values for young adults of same gender...

  17. Fish oil combined with SCFA synergistically prevent tissue accumulation of NEFA during weight loss in obese mice

    DEFF Research Database (Denmark)

    Pedersen, Maiken Højgaard; Lauritzen, Lotte; Hellgren, Lars

    2011-01-01

    Based on their proposed metabolic effects, we examined whether fish oil (FO) and SCFA, alone or in combination, accelerate weight loss and the resultant metabolic improvements. Obesity was induced in male C57BL/6J mice by high-energy feeding for 10 weeks. The mice were transferred to a low-fat diet...... groups lost weight and showed reduced fasting insulin concentrations and reduced liver TAG. However, weight loss on the control-fat diet caused significant increase in hepatic and cardiac NEFA. Substituting 20 % of the fat with SCFA increased weight loss by 48 % and reduced fasting insulin 1·5-fold more...... (2·5w%) for 4 weeks, the source of fat being either FO, a lard–safflower oil mix (control), or both types combined with SCFA. Weight, fasting insulin, tissue and serum lipid concentrations, as well as mRNA amount of genes related to adipose inflammation and hepatic fat oxidation were determined. All...

  18. Prevention of Paclitaxel-induced allodynia by Minocycline: Effect on loss of peripheral nerve fibers and infiltration of macrophages in rats

    Directory of Open Access Journals (Sweden)

    Xin Wen-Jun

    2010-11-01

    Full Text Available Abstract Background Although paclitaxel is a frontline antineoplastic agent for treatment of solid tumors, the paclitaxel-evoked pain syndrome is a serious problem for patients. There is currently no valid drug to prevent or treat the paclitaxel-induced allodynia, partly due to lack of understanding regarding the cellular mechanism. Studies have shown that minocycline, an inhibitor of microglia/macrophage, prevented neuropathic pain and promoted neuronal survival in animal models of neurodegenerative disease. Recently, Cata et al also reported that minocycline inhibited allodynia induced by low-dose paclitaxel (2 mg/kg in rats, but the mechanism is still unclear. Results Here, we investigate by immunohistochemistry the change of intraepidermal nerve fiber (IENF in the hind paw glabrous skin, expression of macrophage and activating transcription factor 3 (ATF3 in DRG at different time points after moderate-dose paclitaxel treatment (cumulative dose 24 mg/kg; 3 × 8 mg/kg in rats. Moreover, we observe the effect of minocycline on the IENF, macrophages and ATF3. The results showed that moderate-dose paclitaxel induced a persisted, gradual mechanical allodynia, which was accompanied by the loss of IENF in the hind paw glabrous skin and up-regulation of macrophages and ATF3 in DRG in rats. The expressions of ATF3 mainly focus on the NF200-positive cells. More importantly, we observed that pretreatment of minocycline at dose of 30 mg/kg or 50 mg/kg, but not 5 mg/kg, prevented paclitaxel-evoked allodynia. The evidence from immunohistochemistry showed that 30 mg/kg minocycline rescued the degeneration of IENF, attenuated infiltration of macrophages and up-regulation of ATF3 induced by paclitaxel treatment in rats. Conclusions Minocycline prevents paclitaxel-evoked allodynia, likely due to its inhibition on loss of IENF, infiltration of macrophages and up-regulation of ATF3 in rats. The finding might provide potential target for preventing paclitaxel

  19. Alendronate prevents postmenopausal bone loss in women without osteoporosis. A double-blind, randomized, controlled trial. Alendronate Osteoporosis Prevention Study Group

    DEFF Research Database (Denmark)

    McClung, M; Clemmesen, B; Daifotis, A;

    1998-01-01

    to one of five regimens: oral placebo; oral alendronate, 1, 5, or 10 mg/d; or oral alendronate, 20 mg/d for 2 years followed by placebo during the third year (20/0 mg/d). MEASUREMENTS: Bone mineral density was measured by dual-energy x-ray absorptiometry. Bone turnover and bone quality were assessed...... with biochemical markers and bone histomorphometry. RESULTS: Alendronate at 5, 10, and 20/0 mg/d increased bone mineral density from baseline at the lumbar spine, femoral neck, and trochanter by 1% to 4% and in the total body by 0.3% to 1.0%; placebo led to losses of 2% to 4% at these sites....... Alendronate, 1 mg/d, attenuated losses relative to those seen with placebo. Alendronate decreased markers of bone resorption to a new steady state by 3 months and decreased markers of bone formation by 6 to 12 months. Bone quality remained normal. At all dosages studied, alendronate had a safety and...

  20. Study of the origin of break outs and application of a detection system; Estudio dle origen de perforaciones y aplicacion de un sistema detector

    Energy Technology Data Exchange (ETDEWEB)

    Cicutti, Carlos; Madias, Jorge; Venica, Ruben; Di Gresia, Gustavo; Petroni, Jorge

    1996-12-31

    Break outs are one of the most serious events in the continuous casting of steel, not only because they produce important losses of money due to maintenance tasks but also because they are dangerous for people working near the caster. In this work, the results of some studies carried out to clarify the origin of break outs in the SIDERAR`s slab caster are presented. As a result of these studies, it was decide to install a detection system to prevent break outs. A brief description of the system and the preliminary results obtained are also presented. (author) 16 refs., 5 figs., 1 tab.

  1. Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women

    DEFF Research Database (Denmark)

    Warming, Lise; Ravn, Pernille; Spielman, Danièle;

    2004-01-01

    OBJECTIVE: To determine the efficacy of estrogen + progestogen therapy with 1 mg 17beta-estradiol and 0.125 mg trimegestone in the prevention of postmenopausal osteoporosis. DESIGN: For this study, 360 healthy, postmenopausal women with osteopenia [lumbar spine bone mineral density (BMD) between ...

  2. Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin.

    Science.gov (United States)

    Lv, Jianwei; Sun, Xiaolei; Ma, Jianxiong; Ma, Xinlong; Xing, Guosheng; Wang, Ying; Sun, Lei; Wang, Jianbao; Li, Fengbo; Li, Yanjun

    2015-12-25

    Periostin has an essential role in mechanotransduction in bone. Naringin, a natural flavonoid, has been evidenced for its osteoprotective role in osteoporosis, while its mechanism is far from clear. Here we show that down-regulation of periostin, and up-regulation of its downstream sclerostin and inactivation of Wnt/β-catenin signaling were implicated in neurectomy-induced bone loss. Naringin could up-regulate periostin and prevent neurectomy-induced deterioration of BMD, trabecular microstructure and bone mechanical characteristics. In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/β-catenin signaling pathways. PMID:26541456

  3. Conjugated linoleic acid prevents ovariectomy-induced bone loss in mice by modulating both osteoclastogenesis and osteoblastogenesis

    OpenAIRE

    Rahman, Md Mizanur; Fernandes, Gabriel; Williams, Paul

    2013-01-01

    Postmenopausal osteoporosis due to estrogen deficiency is associated with severe morbidity and mortality. Beneficial effects of conjugated linoleic acid (CLA) on bone mineral density (BMD) have been reported in mice, rats and humans, but the effect of long term CLA supplementation against ovariectomy-induced bone loss in mice and the mechanisms underlying this effect have not been studied yet. Eight weeks old ovariectomized (Ovx) and sham operated C57BL/6 mice were fed either a diet containin...

  4. Design a Close Loop Cooling System for EA-P1 and Its Auxiliaries to Prevent Loss of Domestic Water

    International Nuclear Information System (INIS)

    Any one of four machines i.e. EA-P1, EA-J4, EA-J5 and EA-J6 may be used to develop vacuum in water box side of main condenser in KANUPP. As per design and operating experience, most efficient one is EA-P1. But since it consumes ample quantity of domestic water which is already very short at KANUPP (even tankers are purchased), its use is avoided. If water used for its cooling is prevented from going to waste and is recycled. EA-P1 operation may be resumed thereby improving efficiency of condenser. We made a close loop for EA-P1 in order to prevent water from going to waste. For this purpose we suggested two close loop schemes and discuss their advantages and drawbacks. Feasibility of both schemes is present in this report and efficient one is proposed for installation at KANUPP. (author)

  5. The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss.

    Directory of Open Access Journals (Sweden)

    Matthew S Thimgan

    Full Text Available Extended periods of waking result in physiological impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep loss, is believed to counter the negative effects of prolonged waking by restoring vital biological processes that are degraded during sleep deprivation. Sleep homeostasis, as with other behaviors, is influenced by both genes and environment. We report here that during periods of starvation, flies remain spontaneously awake but, in contrast to sleep deprivation, do not accrue any of the negative consequences of prolonged waking. Specifically, the homeostatic response and learning impairments that are a characteristic of sleep loss are not observed following prolonged waking induced by starvation. Recently, two genes, brummer (bmm and Lipid storage droplet 2 (Lsd2, have been shown to modulate the response to starvation. bmm mutants have excess fat and are resistant to starvation, whereas Lsd2 mutants are lean and sensitive to starvation. Thus, we hypothesized that bmm and Lsd2 may play a role in sleep regulation. Indeed, bmm mutant flies display a large homeostatic response following sleep deprivation. In contrast, Lsd2 mutant flies, which phenocopy aspects of starvation as measured by low triglyceride stores, do not exhibit a homeostatic response following sleep loss. Importantly, Lsd2 mutant flies are not learning impaired after sleep deprivation. These results provide the first genetic evidence, to our knowledge, that lipid metabolism plays an important role in regulating the homeostatic response and can protect against neuronal impairments induced by prolonged waking.

  6. The Effectiveness of Crataegus orientalis M Bieber. (Hawthorn) Extract Administration in Preventing Alveolar Bone Loss in Rats with Experimental Periodontitis.

    Science.gov (United States)

    Hatipoğlu, Mükerrem; Sağlam, Mehmet; Köseoğlu, Serhat; Köksal, Ekrem; Keleş, Ali; Esen, Hacı Hasan

    2015-01-01

    The purpose of this animal study was to evaluate the effects of hawthorn (Crataeus orientalis M Bieber.) extract on serum oxidative status and alveolar bone loss in experimental periodontitis. Twenty-seven Wistar rats were assigned to one of the following groups: non- ligated+placebo (saline) (NL, n = 9), ligature only+placebo (saline) (LO, n = 9), and ligature and treated with hawthorn extract in saline (H, n = 9) (100 mg/kg orogastrically, once a day for 11 days). Periodontitis was induced by submerging a 4/0 silk ligature in the sulcus of the mandibular right first molars of rats, and the animals were sacrificed after 11 days. Micro-CT examinations were performed for linear and volumetric parameter assessment of alveolar bone. Periodontal tissues were histopathologically examined to assess the differences among the study groups. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Alveolar bone loss was significantly reduced by hawthorn administration compared to LO group (p<0.05). The number of inflammatory cells and osteoclasts in the LO group was significantly higher than that of the NL and H groups (p< 0.05). The number of osteoblasts in the LO and H groups was significantly higher than that of the NL group (p<0.05). TOS and OSI levels were significantly reduced in H group compared to LO group (P <0.05) and TAS levels were similar in H and NL group (p< 0.05). Hawthorn extract showed inhibitory effect on periodontal inflammation and alveolar bone loss by regulating TAS, TOS and OSI levels in periodontal disease in rats when administered systemically. PMID:26030160

  7. Preventing and reversing vacuum-induced optical losses in high-finesse tantalum (V) oxide mirror coatings

    OpenAIRE

    Gangloff, Dorian; Shi, Molu; Wu, Tailin; Bylinskii, Alexei; Braverman, Boris; Nichols, Rosanna; Li, Junru; Aichholz, Kai; Cetina, Marko; Karpa, Leon; Chuang, Isaac; Gutierrez, Michael Steven; Jelenkovic, Branislav; Vuletic, Vladan

    2015-01-01

    High-finesse optical cavities placed under vacuum are foundational platforms in quantum information science with photons and atoms. We study the vacuum-induced degradation of high-finesse optical cavities with mirror coatings composed of SiO[subscript 2]-Ta[subscript 2]O[subscript 5] dielectric stacks, and present methods to protect these coatings and to recover their initial low loss levels. For separate coatings with reflectivities centered at 370 nm and 422 nm, a vacuum-induced continuous ...

  8. Preventing and Reversing Vacuum-Induced Optical Losses in High-Finesse Tantalum (V) Oxide Mirror Coatings

    OpenAIRE

    Gangloff, Dorian; Shi, Molu; Wu, Tailin; Bylinskii, Alexei; Braverman, Boris; Gutierrez, Michael; Nichols, Rosanna; Li, Junru; Aichholz, Kai; Cetina, Marko; Karpa, Leon; Jelenković, Branislav; Chuang, Isaac; Vuletić, Vladan

    2015-01-01

    We study the vacuum-induced degradation of high-finesse optical cavities with mirror coatings composed of SiO$_2$-Ta$_{2}$O$_{5}$ dielectric stacks, and present methods to protect these coatings and to recover their initial quality factor. For separate coatings with reflectivities centered at 370 nm and 422 nm, a vacuum-induced continuous increase in optical loss occurs if the surface-layer coating is made of Ta$_{2}$O$_{5}$, while it does not occur if it is made of SiO$_2$. The incurred opti...

  9. Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

    OpenAIRE

    Ghosh, Anamitra; Roy, Avik; Liu, Xiaojuan; Kordower, Jeffrey H.; Mufson, Elliott J.; Hartley, Dean M.; Ghosh, Sankar; Mosley, R. Lee; Gendelman, Howard E; Pahan, Kalipada

    2007-01-01

    Parkinson's disease (PD) is the second most common neurodegenerative disorder. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. The present study evaluates the ability of peptide corresponding to the NF-κB essential modifier-binding domain (NBD) of IκB kinase α (IKKα) or IKKβ to prevent nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD and establish a role for NF-κB in human parki...

  10. Preventing and Reversing Vacuum-Induced Optical Losses in High-Finesse Tantalum (V) Oxide Mirror Coatings

    CERN Document Server

    Gangloff, Dorian; Wu, Tailin; Bylinskii, Alexei; Braverman, Boris; Gutierrez, Michael; Nichols, Rosanna; Li, Junru; Aichholz, Kai; Cetina, Marko; Karpa, Leon; Jelenković, Branislav; Chuang, Isaac; Vuletić, Vladan

    2015-01-01

    We study the vacuum-induced degradation of high-finesse optical cavities with mirror coatings composed of SiO$_2$-Ta$_{2}$O$_{5}$ dielectric stacks, and present methods to protect these coatings and to recover their initial quality factor. For separate coatings with reflectivities centered at 370 nm and 422 nm, a vacuum-induced continuous increase in optical loss occurs if the surface-layer coating is made of Ta$_{2}$O$_{5}$, while it does not occur if it is made of SiO$_2$. The incurred optical loss can be reversed by filling the vacuum chamber with oxygen at atmospheric pressure, and the recovery rate can be strongly accelerated by continuous laser illumination at 422 nm. Both the degradation and the recovery processes depend strongly on temperature. We find that a 1 nm-thick layer of SiO$_2$ passivating the Ta$_{2}$O$_{5}$ surface layer is sufficient to reduce the degradation rate by more than a factor of 10, strongly supporting surface oxygen depletion as the primary degradation mechanism.

  11. Preventing and reversing vacuum-induced optical losses in high-finesse tantalum (V) oxide mirror coatings

    Science.gov (United States)

    Gangloff, Dorian; Shi, Molu; Wu, Tailin; Bylinskii, Alexei; Braverman, Boris; Gutierrez, Michael; Nichols, Rosanna; Li, Junru; Aichholz, Kai; Cetina, Marko; Karpa, Leon; Jelenković, Branislav; Chuang, Isaac; Vuletić, Vladan

    2015-07-01

    We study the vacuum-induced degradation of high-finesse optical cavities with mirror coatings composed of SiO$_2$-Ta$_{2}$O$_{5}$ dielectric stacks, and present methods to protect these coatings and to recover their initial quality factor. For separate coatings with reflectivities centered at 370 nm and 422 nm, a vacuum-induced continuous increase in optical loss occurs if the surface-layer coating is made of Ta$_{2}$O$_{5}$, while it does not occur if it is made of SiO$_2$. The incurred optical loss can be reversed by filling the vacuum chamber with oxygen at atmospheric pressure, and the recovery rate can be strongly accelerated by continuous laser illumination at 422 nm. Both the degradation and the recovery processes depend strongly on temperature. We find that a 1 nm-thick layer of SiO$_2$ passivating the Ta$_{2}$O$_{5}$ surface layer is sufficient to reduce the degradation rate by more than a factor of 10, strongly supporting surface oxygen depletion as the primary degradation mechanism.

  12. Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect.

    Science.gov (United States)

    Beluzi, Mércia; Peres, Sidney B; Henriques, Felipe S; Sertié, Rogério A L; Franco, Felipe O; Santos, Kaltinaitis B; Knobl, Pâmela; Andreotti, Sandra; Shida, Cláudio S; Neves, Rodrigo X; Farmer, Stephen R; Seelaender, Marília; Lima, Fábio B; Batista, Miguel L

    2015-01-01

    Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. The former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglitazone (PGZ) was proposed to exhibit anti-cancer properties, including a reduction in insulin resistance and adipose tissue loss; nevertheless, few studies have evaluated its effect on survival. For greater insight into a potential anti-cachectic effect due to PGZ, 8-week-old male Wistar rats were subcutaneously inoculated with 1 mL (2×107) of Walker 256 tumor cells. The animals were randomly assigned to two experimental groups: TC (tumor + saline-control) and TP5 (tumor + PGZ/5 mg). Body weight, food ingestion and tumor growth were measured at baseline and after removal of tumor on days 7, 14 and 26. Samples from different visceral adipose tissue (AT) depots were collected on days 7 and 14 and stored at -80o C (5 to 7 animals per day/group). The PGZ treatment showed an increase in the survival average of 27.3% (P< 0.01) when compared to TC. It was also associated with enhanced body mass preservation (40.7 and 56.3%, p< 0.01) on day 14 and 26 compared with the TC group. The treatment also reduced the final tumor mass (53.4%, p<0.05) and anorexia compared with the TC group during late-stage cachexia. The retroperitoneal AT (RPAT) mass was preserved on day 7 compared with the TC group during the same experimental period. Such effect also demonstrates inverse relationship with tumor growth, on day 14. Gene expression of PPAR-γ, adiponectin, LPL and C/EBP-α from cachectic rats was upregulated after PGZ. Glucose uptake from adipocyte cells (RPAT) was entirely re-established due to

  13. Pioglitazone treatment increases survival and prevents body weight loss in tumor-bearing animals: possible anti-cachectic effect.

    Directory of Open Access Journals (Sweden)

    Mércia Beluzi

    Full Text Available Cachexia is a multifactorial syndrome characterized by profound involuntary weight loss, fat depletion, skeletal muscle wasting, and asthenia; all symptoms are not entirely attributable to inadequate nutritional intake. Adipose tissue and skeletal muscle loss during cancer cachexia development has been described systematically. The former was proposed to precede and be more rapid than the latter, which presents a means for the early detection of cachexia in cancer patients. Recently, pioglitazone (PGZ was proposed to exhibit anti-cancer properties, including a reduction in insulin resistance and adipose tissue loss; nevertheless, few studies have evaluated its effect on survival. For greater insight into a potential anti-cachectic effect due to PGZ, 8-week-old male Wistar rats were subcutaneously inoculated with 1 mL (2×107 of Walker 256 tumor cells. The animals were randomly assigned to two experimental groups: TC (tumor + saline-control and TP5 (tumor + PGZ/5 mg. Body weight, food ingestion and tumor growth were measured at baseline and after removal of tumor on days 7, 14 and 26. Samples from different visceral adipose tissue (AT depots were collected on days 7 and 14 and stored at -80o C (5 to 7 animals per day/group. The PGZ treatment showed an increase in the survival average of 27.3% (P< 0.01 when compared to TC. It was also associated with enhanced body mass preservation (40.7 and 56.3%, p< 0.01 on day 14 and 26 compared with the TC group. The treatment also reduced the final tumor mass (53.4%, p<0.05 and anorexia compared with the TC group during late-stage cachexia. The retroperitoneal AT (RPAT mass was preserved on day 7 compared with the TC group during the same experimental period. Such effect also demonstrates inverse relationship with tumor growth, on day 14. Gene expression of PPAR-γ, adiponectin, LPL and C/EBP-α from cachectic rats was upregulated after PGZ. Glucose uptake from adipocyte cells (RPAT was entirely re

  14. Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice.

    Science.gov (United States)

    Martínez-Vega, Raquel; Partearroyo, Teresa; Vallecillo, Néstor; Varela-Moreiras, Gregorio; Pajares, María A; Varela-Nieto, Isabel

    2015-12-01

    Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients well known for their beneficial effects, among others on cognitive development and maintenance, inflammation and oxidative stress. Previous studies have shown an inverse association between high plasma levels of PUFAs and age-related hearing loss, and the relationship between low serum folate and elevated plasma homocysteine levels and hearing loss. Therefore, we used C57BL/6J mice and long-term omega-3 supplementation to evaluate the impact on hearing by analyzing their auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) thresholds. The omega-3 group showed significantly lower ABR hearing thresholds (~25 dB sound pressure level) and higher DPOAE amplitudes in mid-high frequencies when compared to the control group. These changes did not correlate with alterations between groups in plasma homocysteine or serum folate levels as measured by high-performance liquid chromatography and a microbiological method, respectively. Aging in the control group was associated with imbalanced cytokine expression toward increased proinflammatory cytokines as determined by quantitative reverse transcriptase polymerase chain reaction; these changes were prevented by omega-3 supplementation. Genes involved in homocysteine metabolism showed decreased expression during aging of control animals, and only alterations in Bhmt and Cbs were significantly prevented by omega-3 feeding. Western blotting showed that omega-3 supplementation precluded the CBS protein increase detected in 10-month-old controls but also produced an increase in BHMT protein levels. Altogether, the results obtained suggest a long-term protective role of omega-3 supplementation on cochlear metabolism and progression of hearing loss. PMID:26321228

  15. Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats

    Directory of Open Access Journals (Sweden)

    Ayse Er

    2013-01-01

    Full Text Available The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 160 μg kg−1 on day 10 of pregnancy; and the azithromycin + LPS group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy and LPS was administered intravenously at 160 μg kg−1 on day 10 of pregnancy. Blood samples were obtained from the tail vein on day 10 of the experiment. Pregnancy rates were determined. Tumor necrosis factor-alpha (TNF-α and interleukin (IL-10 levels were measured by ELISA. Azithromycin prevented ( LPS-induced pregnancy loss. Higher TNF-α and IL-10 levels were measured ( in the LPS and azithromycin + LPS groups, respectively. In conclusion, azithromycin may be useful in infection- or endotoxemia-dependent pregnancy loss.

  16. Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.

    Science.gov (United States)

    Jiang, X; Nguyen, T T; Tian, W; Sung, Y K; Yuan, K; Qian, J; Rajadas, J; Sallenave, J-M; Nickel, N P; de Jesus Perez, V; Rabinovitch, M; Nicolls, M R

    2015-07-01

    The loss of a functional microvascular bed in rejecting solid organ transplants is correlated with fibrotic remodeling and chronic rejection; in lung allografts, this pathology is predicted by bronchoalveolar fluid neutrophilia which suggests a role for polymorphonuclear cells in microcirculatory injury. In a mouse orthotopic tracheal transplant model, cyclosporine, which primarily inhibits T cells, failed as a monotherapy for preventing microvessel rejection and graft ischemia. To target neutrophil action that may be contributing to vascular injury, we examined the effect of a neutrophil elastase inhibitor, elafin, on the microvascular health of transplant tissue. We showed that elafin monotherapy prolonged microvascular perfusion and enhanced tissue oxygenation while diminishing the infiltration of neutrophils and macrophages and decreasing tissue deposition of complement C3 and the membrane attack complex, C5b-9. Elafin was also found to promote angiogenesis through activation of the extracellular signal-regulated kinase (ERK) signaling pathway but was insufficient as a single agent to completely prevent tissue ischemia during acute rejection episodes. However, when combined with cyclosporine, elafin effectively preserved airway microvascular perfusion and oxygenation. The therapeutic strategy of targeting neutrophil elastase activity alongside standard immunosuppression during acute rejection episodes may be an effective approach for preventing the development of irreversible fibrotic remodeling. PMID:25727073

  17. Electroweak symmetry breaking through supersymmetry breaking

    International Nuclear Information System (INIS)

    The connection between the scales of SU(2) x U(1) gauge symmetry breaking and supersymmetry breaking is didactically displayed in the framework of a T.O.Y. (Theory Overestimating Yukawas) model, a version of the (M + 1) SSM (supersymmetric extension of the standard model with a gauge singlet) in which the relevant parameters are determined in the fixed point regime. Some conspicuous features of supersymmetric particle physics are reviewed in the light of this simplified model. An alternative theory corresponding to lim (M + 1) SSM → MSSM, leads to interesting inequalities among the supersymmetric breaking parameters of the MSSM

  18. Auditoria dos programas de prevenção de perdas auditivas em Curitiba (PPPA Hearing loss prevention programs control of Curitiba (HLPP

    Directory of Open Access Journals (Sweden)

    Regina C.M. Cavalli

    2004-06-01

    Full Text Available OBJETIVO: O presente trabalho teve como objetivo examinar se medidas práticas de prevenção de perdas auditivas, adotadas por indústrias de Curitiba e região metropolitana, atendem às exigências da legislação trabalhista vigente e recomendações científicas que abordam este tema. FORMA DE ESTUDO: Coorte transversal. MATERIAL E MÉTODO: Um questionário elaborado pelo instituto americano National Institute for Occupational Safety and Health (NIOSH em 1996, para auditoria de programas de prevenção de perdas auditivas (PPPA, nos serviu de instrumento para a coleta de dados. O instrumento original possui 89 questões divididas em oito temas relacionados à prática dos programas: treinamento e educação, envolvimento do supervisor, medição do ruído, controle de Engenharia e Administrativo, monitoração audiométrica e manutenção dos registros, encaminhamentos, equipamento de proteção individual e questões administrativas. A coleta de dados foi realizada com Médicos do Trabalho, Engenheiros e/ou Técnicos de Segurança das indústrias. As empresas foram divididas em dois grupos: o das empresas que possuem um PPPA e o das que não possuem. CONCLUSÃO: Com base nos dados obtidos concluímos que não houve diferença significativa de conduta entre os grupos e que ambos cumprem parcialmente a legislação trabalhista relacionada à prevenção dos efeitos do ruído. Quanto às questões que abordam aspectos que se excedem às exigências legais, concluímos que as empresas que possuem PPPA dedicam maiores esforços à prevenção de perdas auditivas. Com estes dados identificamos pontos fortes e fracos das medidas que vêm sendo adotadas pelas indústrias da região, os quais poderão nos direcionar à elaboração de medidas preventivas mais efetivas e de propostas para revisão da legislação vigente.AIM: The objective of this study is to examine if the hearing loss prevention practices in industries located in the greater

  19. Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells.

    Science.gov (United States)

    Sachs, Norman; Secades, Pablo; van Hulst, Laura; Kreft, Maaike; Song, Ji-Ying; Sonnenberg, Arnoud

    2012-12-26

    Progression through the various stages of skin tumorigenesis is correlated with an altered expression of the integrin α3β1, suggesting that it plays an important role in the tumorigenic process. Using epidermis-specific Itga3 KO mice subjected to the 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate two-stage skin carcinogenesis protocol, we demonstrate that efficient tumor development is critically dependent on the presence of α3β1. In the absence of α3β1, tumor initiation is dramatically decreased because of increased epidermal turnover, leading to a loss of DMBA-initiated label-retaining keratinocytes. Lineage tracing revealed emigration of α3-deficient keratinocytes residing in the bulge of the hair follicle toward the interfollicular epidermis. Furthermore, tumor growth and cell proliferation were strongly reduced in mice with an epidermis-specific deletion of Itga3. However, the rate of progression of α3β1-null squamous cell carcinomas to undifferentiated, invasive carcinomas was increased. Therefore, α3β1 critically affects skin carcinogenesis with opposing effects early and late in tumorigenesis. PMID:23236172

  20. Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals.

    Science.gov (United States)

    Botezelli, José D; Coope, Andressa; Ghezzi, Ana C; Cambri, Lucieli T; Moura, Leandro P; Scariot, Pedro P M; Gaspar, Rodrigo Stellzer; Mekary, Rania A; Ropelle, Eduardo Rochete; Pauli, José Rodrigo

    2016-01-01

    The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. PMID:27487746

  1. Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals

    Science.gov (United States)

    Botezelli, José D.; Coope, Andressa; Ghezzi, Ana C.; Cambri, Lucieli T.; Moura, Leandro P.; Scariot, Pedro P. M.; Gaspar, Rodrigo Stellzer; Mekary, Rania A.; Ropelle, Eduardo Rochete; Pauli, José Rodrigo

    2016-01-01

    The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8–14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises). After the 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, and inflammation were evaluated and analyzed. The strength protocol exerted greater effects on glucose homeostasis, insulin sensitivity, and liver lipid contents than other protocols (all P < 0.05). All three exercise protocols induced a remarkable reduction in inflammation, tissue triglyceride content, and inflammatory pathways, which was achieved through c-Jun NH2-terminal kinase (JNK) phosphorylation and factor nuclear kappa B (NFkB) activation in both the liver and the muscle. Our data suggest that strength training reduced the severity of most of the metabolic disorders induced by a fructose-rich diet and could be the most effective strategy to prevent or treat fructose-induced metabolic diseases. PMID:27487746

  2. A Stylistic Analysis of Break,Break,Break

    Institute of Scientific and Technical Information of China (English)

    李瑶

    2015-01-01

    Break, Break, Break is a poem by Alfred Lord Tennyson, the Poet Laureate during the Queen Victoria's reign. This exquisite little poem is wel known for the poet's grief-stricken feelings and heart-broken emotions over the premature death of his best friend, Arthur Henry Halam. Most of the previous studies on this poem focus on the emotional level to consider it as an elegy, expressing sorrow and lamentation for the death of a particular person. However, in order to have a deep understanding in general, this paper analyzes the poem based on the stylistic theory, concerning on the lexical level and the semantic level. It aims at helping the readers to cultivate a sense of appropriateness, to sharpen the understanding and appreciation of literary works and to achieve adaptation in translation.

  3. Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice.

    Science.gov (United States)

    Park, Sun-Hyang; Kim, Ju-Young; Cheon, Yoon-Hee; Baek, Jong Min; Ahn, Sung-Jun; Yoon, Kwon-Ha; Lee, Myeung Su; Oh, Jaemin

    2016-04-01

    Protocatechuic acid (PCA) plays a critical role in nutritional metabolism; it is a major metabolite of anthocyanins, which are flavonoids with a range of health benefits. PCA has a variety of biological activities including anti-oxidant, antiinflammatory, anti-apoptosis, and anti-microbial activities. However, the pharmacological effect of PCA, especially on osteoclastogenesis, remains unknown. We examined the effect of PCA on receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation and bone resorption. PCA dose-dependently inhibited RANKL-induced osteoclast differentiation in mouse bone marrow macrophages (BMMs) and suppressed the bone-resorbing activity of mature osteoclasts. At the molecular level, PCA suppressed RANKL-induced phosphorylation of JNK among MAPKs only, without significantly affecting the early signaling pathway. PCA also suppressed RANKL-stimulated expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1) at the mRNA and protein levels, without altering c-Fos mRNA expression. Additionally, PCA down-regulated the expression of downstream osteoclastogenesis-related genes including β3-integrin, DC-STAMP, OC-STAMP, Atp6v0d2, CTR, and CtsK. Mice treated with PCA efficiently recovered from lipopolysaccharide-induced bone loss in vivo. Thus, PCA inhibits RANKL-induced osteoclast differentiation and function by suppressing JNK signaling, c-Fos stability, and expression of osteoclastic marker genes. These results suggest that PCA could be useful in treatment of inflammatory bone disorders. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26792397

  4. A Theoretical Model for the Prediction of Siphon Breaking Phenomenon

    International Nuclear Information System (INIS)

    A siphon phenomenon or siphoning often refers to the movement of liquid from a higher elevation to a lower one through a tube in an inverted U shape (whose top is typically located above the liquid surface) under the action of gravity, and has been used in a variety of reallife applications such as a toilet bowl and a Greedy cup. However, liquid drainage due to siphoning sometimes needs to be prevented. For example, a siphon breaker, which is designed to limit the siphon effect by allowing the gas entrainment into a siphon line, is installed in order to maintain the pool water level above the reactor core when a loss of coolant accident (LOCA) occurs in an open-pool type research reactor. In this paper, we develop a theoretical model to predict the siphon breaking phenomenon. In this paper, a theoretical model to predict the siphon breaking phenomenon is developed. It is shown that the present model predicts well the fundamental features of the siphon breaking phenomenon and undershooting height

  5. A Theoretical Model for the Prediction of Siphon Breaking Phenomenon

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Youngmin; Kim, Young-In; Seo, Jae-Kwang; Kim, Keung Koo; Yoon, Juhyeon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    A siphon phenomenon or siphoning often refers to the movement of liquid from a higher elevation to a lower one through a tube in an inverted U shape (whose top is typically located above the liquid surface) under the action of gravity, and has been used in a variety of reallife applications such as a toilet bowl and a Greedy cup. However, liquid drainage due to siphoning sometimes needs to be prevented. For example, a siphon breaker, which is designed to limit the siphon effect by allowing the gas entrainment into a siphon line, is installed in order to maintain the pool water level above the reactor core when a loss of coolant accident (LOCA) occurs in an open-pool type research reactor. In this paper, we develop a theoretical model to predict the siphon breaking phenomenon. In this paper, a theoretical model to predict the siphon breaking phenomenon is developed. It is shown that the present model predicts well the fundamental features of the siphon breaking phenomenon and undershooting height.

  6. Development of technique for estimating primary cooling system break diameter in predicting nuclear emergency event sequence

    International Nuclear Information System (INIS)

    If an emergency event occurs in a nuclear power plant, appropriate action is selected and taken in accordance with the plant status, which changes from time to time, in order to prevent escalation and mitigate the event consequences. It is thus important to predict the event sequence and identify the plant behavior resulting from the action taken. In predicting the event sequence during a loss-of-coolant accident (LOCA), it is necessary to estimate break diameter. The conventional method for this estimation is time-consuming, since it involves multiple sensitivity analyses to determine the break diameter that is consistent with the plant behavior. To speed up the process of predicting the nuclear emergency event sequence, a new break diameter estimation technique that is applicable to pressurized water reactors was developed in this study. This technique enables the estimation of break diameter using the plant data sent from the safety parameter display system (SPDS), with focus on the depressurization rate in the reactor cooling system (RCS) during LOCA. The results of LOCA analysis, performed by varying the break diameter using the MAAP4 and RELAP5/MOD3.2 codes, confirmed that the RCS depressurization rate could be expressed by the log linear function of break diameter, except in the case of a small leak, in which RCS depressurization is affected by the coolant charging system and the high-pressure injection system. A correlation equation for break diameter estimation was developed from this function and tested for accuracy. Testing verified that the correlation equation could estimate break diameter accurately within an error of approximately 16%, even if the leak increases gradually, changing the plant status. (author)

  7. Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss

    Institute of Scientific and Technical Information of China (English)

    LIU Xin; YANG Weiyan; HAN Dongyi; JIN Zhengce; GUAN Minxin; DAI Pu; HUANG Deliang; YUAN Huijun; LI Weiming; YU Fei; ZHANG Xin; KANG Dongyang; CAO Juyang

    2006-01-01

    To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection ofmtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics.

  8. Study of the impact of food irradiation on preventing losses: Experience in Africa. Proceedings of a final research co-ordination meeting

    International Nuclear Information System (INIS)

    There have been positive developments on food irradiation in different regions of the world, especially in the United States of America and several Asian and Latin American countries. In some countries in Africa, this technology has been studied in the past few decades with encouraging results. To assist these countries in conducting pilot scale research and development on irradiation of specific commodities of interest to them including market testing and feasibility to establish commercial irradiators for multi-purpose application, a Coordinated Research Project (CRP) on Impact of Irradiation to Prevent Food Losses in Africa was carried out between 1995 and 1999. This CRP demonstrated that food irradiation has a potential to reduce losses of basic staple food crops including yams, dried and smoked fish, potatoes and onions through pilot scale experiments carried out in some African countries. Small scale market testing of such irradiated food such as spices, potatoes and onions showed encouraging results. In some countries (Cote d'Ivoire, Egypt, Ghana, Senegal and South Africa), it is feasible to establish commercial irradiation facilities for treating food. In Morocco, irradiation shows a potential to meet quarantine requirements in international food trade. It should be noted that commercial scale application of irradiation of some food products has been carried out in South Africa since the 1980s

  9. The timing of agricultural production in hazard-prone areas to prevent losses at peak-risk periods: A case of Malawi, Madagascar and Mozambique

    Directory of Open Access Journals (Sweden)

    Leandri Kruger

    2016-01-01

    Full Text Available Hazard-prone areas in southern Africa experience many natural hazards, which include cyclones, floods and droughts. The severe climatic conditions of southern Africa have an especially large impact on the agricultural practices of small-scale farmers. These hazards should be mitigated to ensure more resilient communities and food security. This study mainly focuses on the timing of agricultural production in hazard-prone areas to prevent losses at peak-risk periods by adapting the agricultural cycle. This study focuses on the agricultural activities of small-scale farmers in Malawi, Madagascar and Mozambique. A literature review is presented, and a mixed-method research design were followed to determine the timing of production followed by these small-scale farmers and its impact on production and food security. Although this study found that the small-scale farmers generally plant with the first rains, it is recommended by literature that early planting should be practised to ensure optimal production. It is also recommended that small-scale farmers should implement watermanagement techniques for dry periods, and when farmers practice late planting, the use of residual-moisture retention should be utilised as a mitigation measure. This will in effect ensure that the communities are less vulnerable during peak-risk periods by improving or ensuring food security. Therefore, adapting the planting and production time in these hazardprone areas at peak-risk periods could limit losses and increase communities’ resilience.

  10. Loss to Followup: A Major Challenge to Successful Implementation of Prevention of Mother-to-Child Transmission of HIV-1 Programs in Sub-Saharan Africa.

    Science.gov (United States)

    Kalembo, Fatch W; Zgambo, Maggie

    2012-01-01

    Purpose. The purpose of this paper was to explore how loss to followup (LFTU) has affected the successful implementation of prevention of mother to child transmission of HIV-1 (PMTCT) programs in sub-Saharan Africa. Methods. We conducted an electronic search from the following databases PubMed, ScienceDirect, Directory of Open Access Journals (DOAJs), and PyscINFO. Additional searches were made in WHO, UNAIDS, UNICEF, Google, and Google scholar websites for (1) peer-reviewed published research, (2) scientific and technical reports, and (3) papers presented on scientific conferences. Results. A total of 678 articles, published from 1990 to 2011, were retrieved. Only 44 articles met our inclusion criteria and were included in the study. The rates of LTFU of mother-child pairs ranged from 19% to 89.4 in the reviewed articles. Health facility factors, fear of HIV-1 test, stigma and discrimination, home deliveries and socioeconomic factors were identified as reasons for LTFU. Conclusion. There is a great loss of mother-child pairs to follow up in PMTCT programs in sub-Saharan Africa. There is need for more research studies to develop public health models of care that can help to improve followup of mother-child pairs in PMTCT programs in Sub-Saharan Africa. PMID:24052879

  11. Menopause and Bone Loss

    Science.gov (United States)

    Fact Sheet & Menopause Bone Loss How are bone loss and menopause related? Throughout life your body keeps a balance between the loss ... The sooner you take steps to prevent bone loss, the lower your risk of osteoporosis later in life. If you are skipping menstrual periods, have had ...

  12. Preventing Catastrophes from Data Loss

    Science.gov (United States)

    Goldsborough, Reid

    2004-01-01

    What's the worst thing that can happen to your computer? Worse than a hard disk crash, virus infection, spam assault, denial-of-service attack, hacker take-over, fire, flood, or other human, mechanical or natural disaster is a faulty backup when you really need it. If the computer blows up, as long as your data is backed up securely, you can…

  13. Thermochemistry, tool for loss prevention

    International Nuclear Information System (INIS)

    The general philosophy and a synopsis of experimental techniques and methodologies for risk assessment of synthesis processes are exposed. All of them try to get the maximum information concerning the thermochemistry of the process, including side reactions. The first results of a comparison study involving different european groups open the door to the homologation of methodologies

  14. Dynamical supersymmetry breaking

    International Nuclear Information System (INIS)

    Supersymmetry, and in particular, dynamical supersymmetry breaking, offers the hope of a natural solution of the gauge hierarchy problem in grand unification. I briefly review recent work on dynamical supersymmetry breaking in four-dimensional Higgs theories and its application to grand unified model building

  15. Transplantation of human umbilical cord blood-derived mesenchymal stem cells or their conditioned medium prevents bone loss in ovariectomized nude mice.

    Science.gov (United States)

    An, Jee Hyun; Park, Hyojung; Song, Jung Ah; Ki, Kyung Ho; Yang, Jae-Yeon; Choi, Hyung Jin; Cho, Sun Wook; Kim, Sang Wan; Kim, Seong Yeon; Yoo, Jeong Joon; Baek, Wook-Young; Kim, Jung-Eun; Choi, Soo Jin; Oh, Wonil; Shin, Chan Soo

    2013-03-01

    Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in stem cell therapy. We studied the effects of systemic injection of human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss in nude mice. Ten-week-old female nude mice were divided into six groups: Sham-operated mice treated with vehicle (Sham-Vehicle), OVX mice subjected to UCB-MSCs (OVX-MSC), or human dermal fibroblast (OVX-DFB) transplantation, OVX mice treated with UCB-MSC CM (OVX-CM), zoledronate (OVX-Zol), or vehicle (OVX-Vehicle). Although the OVX-Vehicle group exhibited significantly less bone mineral density (BMD) gain compared with the Sham-Vehicle group, transplantation of hUCB-MSCs (OVX-MSC group) has effectively prevented OVX-induced bone mass attenuation. Notably, the OVX-CM group also showed BMD preservation comparable to the OVX-MSC group. In addition, microcomputed tomography analysis demonstrated improved trabecular parameters in both the OVX-MSC and OVX-CM groups compared to the OVX-Vehicle or OVX-DFB group. Histomorphometric analysis showed increased bone formation parameters, accompanied by increased serum procollagen type-I N-telopeptide levels in OVX-MSC and OVX-CM mice. However, cell-trafficking analysis failed to demonstrate engraftment of MSCs in bone tissue 48 h after cell infusion. In vitro, hUCB-MSC CM increased alkaline phosphatase (ALP) activity in human bone marrow-derived MSCs and mRNA expression of collagen type 1, Runx2, osterix, and ALP in C3H10T1/2 cells. Furthermore, hUCB-MSC CM significantly increased survival of osteocyte-like MLO-Y4 cells, while it inhibited osteoclastic differentiation. To summarize, transplantation of hUCB-MSCs could effectively prevent OVX-mediated bone loss in nude mice, which appears to be mediated by a paracrine mechanism rather than direct engraftment of the MSCs. PMID:23215868

  16. A review of the cost-effectiveness and suitability of mitigation strategies to prevent phosphorus loss from dairy farms in New Zealand and Australia.

    Science.gov (United States)

    McDowell, Richard W; Nash, David

    2012-01-01

    The loss of phosphorus (P) from land to water is detrimental to surface water quality in many parts of New Zealand and Australia. Farming, especially pasture-based dairying, can be a source of P loss, but preventing it requires a range of fully costed strategies because little or no subsidies are available and the effectiveness of mitigation strategies varies with different farm management systems, topography, stream density, and climate. This paper reviews the cost-effectiveness of mitigation strategies for New Zealand and Australian dairy farms, grouping strategies into (i) management (e.g., decreasing soil test P, fencing streams off from stock, or applying low-water-soluble P fertilizers), (ii) amendments (e.g., alum or red mud [Bauxite residue]), and (iii) edge-of-field mitigations (e.g., natural or constructed wetlands). In general, on-farm management strategies were the most cost-effective way of mitigating P exports (cost range, $0 to $200 per kg P conserved). Amendments, added to tile drains or directly to surface soil, were often constrained by supply or were labor intensive. Of the amendments examined, red mud was cost effective where cost was offset by improved soil physical properties. Edge-of-field strategies, which remove P from runoff (i.e., wetlands) or prevent runoff (i.e., irrigation runoff recycling systems), were generally the least cost effective, but their benefits in terms of improved overall resource efficiency, especially in times of drought, or their effect on other contaminants like N need to be considered. By presenting a wide range of fully costed strategies, and understanding their mechanisms, a farmer or farm advisor is able to choose those that suit their farm and maintain profitability. Further work should examine the potential for targeting strategies to areas that lose the most P in time and space to maximize the cost-effectiveness of mitigation strategies, quantify the benefits of multiple strategies, and identify changes to

  17. Loss of bifurcation patency after cross-over stenting of ostial lesions in superficial femoral artery: possible causes, prevention and reintervention

    Institute of Scientific and Technical Information of China (English)

    Jiang Junhao; Chen Bin; Dong Zhihui; Shi Yun; Li Weimiao; Yue Jianing

    2014-01-01

    Background Crossover stenting across the origin of the profunda femoral artery (PFA) and occasionally into the common femoral artery (CFA) is commonly used after suboptimal balloon angioplasty of ostial occlusive lesions of the superficial femoral artery (SFA) involving the bifurcation.Late stent occlusion at the bifurcation is not rare and results in severe lower extremity ischemia.Therefore,we tried to assess its possible causes,prevention and reintervention.Methods Using a prospectively maintained single-center database,12-month femoral bifurcation patency was retrospectively compared and lesion and procedural predictors of stent occlusion were determined among 63 patients (64 lesions) who between July 2011 and February 2013 underwent crossover (36 non-jailed and 15 jailed SFA,and 12 distal and 1 complete CFA) stenting of de novo ostial SFA lesions.Results Twelve-month overall patency rate at the femoral bifurcation was 88%,with no significant difference between jailed-ostial SFA (80%) and distal CFA (67%) stenting (P=0.731),and significant differences between either and non-jailed ostial stenting (100%,P=0.035 and 0.002).When PFA ostium was jailed by the stent,patients with preexisting CFA or PFA lesions had a 12-month bifurcation patency rate of 20%,significantly lower than those with simple ostial SFA lesions (83%,P=0.015).Stent induced intimal hyperplasia caused bifurcation occlusion in 6 surgical reintervention cases.Conclusions In crossover stenting of ostial lesions in SFA,bifurcation patency loss was significantly higher in distal CFA and jailed ostial SFA stenting than non-jailed ostial SFA stenting.Preexisting CFA or PFA lesion is a significant risk factor for bifurcation patency loss when PFA ostium is jailed by crossover stenting.

  18. Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction

    Directory of Open Access Journals (Sweden)

    Pan Jing

    2012-08-01

    Full Text Available Abstract Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. The results of our recent experiments indicated that curcumin could protect dopaminergic neurons from apoptosis in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP mouse model of Parkinson’s disease (PD. The death of dopaminergic neurons and the loss of dopaminergic axon in the striatum were significantly suppressed by curcumin in MPTP mouse model. Further studies showed that curcumin inhibited JNKs hyperphosphorylation induced by MPTP treatment. JNKs phosphorylation can cause translocation of Bax to mitochondria and the release of cytochrome c which both ultimately contribute to mitochondria-mediated apoptosis. These pro-apoptosis effect can be diminished by curcumin. Our experiments demonstrated that curcumin can prevent nigrostriatal degeneration by inhibiting the dysfunction of mitochondrial through suppressing hyperphosphorylation of JNKs induced by MPTP. Our results suggested that JNKs/mitochondria pathway may be a novel target in the treatment of PD patients.

  19. Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers

    Directory of Open Access Journals (Sweden)

    Afsaneh Doosti

    2014-01-01

    Full Text Available Previous studies revealed the role of antioxidant agents in prevention of noise induced hearing loss (NIHL. The aim of this study was to compare the protective effect of N-acetyl-cysteine (NAC and ginseng on protection of NIHL in textile workers exposed to continuous noise in daily working. In this study, 48 participants were randomly allocated to three groups; Group I received NAC 1200 mg/day, Group II received ginseng 200 mg/day, and Group III (control group received no supplement. Pure tone audiometry and high frequency audiometry were performed preshift before and after 14 days (on day 15. Linear regression analysis results showed reduced noise-induced temporary threshold shift (TTS for NAC and ginseng groups at 4, 6 and 16 kHz (P < 0.001 in both ears. Furthermore, the protective effects were more prominent in NAC than ginseng. Our results show that NAC and ginseng can reduce noise induced TTS in workers exposed to occupational noise. Further studies are needed to prove antioxidants benefits in hearing conservation programs.

  20. Break the ice

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Jacky:My sister is mad at me.She refuses(拒绝)to talk to me.What can I do to break the ice?Ella:You can buy her a little gift.Break的意思是"打破",ice是指"冰块"。冰是又冷又硬的东西,作为俗语break the ice是指"打破沉默(僵局)"。Jacky惹妹妹生气,妹妹不理他了,他能通过送小礼物break the ice吗?

  1. Supersymmetry breaking from superstrings

    International Nuclear Information System (INIS)

    The gauge hierarchy problem is briefly reviewed and a class of effective field theories obtained from superstrings is described. These are characterized by a classical symmetry, related to the space-time duality of string theory, that is responsible for the suppression of observable supersymmetry breaking effects. At the quantum level, the symmetry is broken by anomalies that provide the seed of observable supersymmetry breaking, and an acceptably large gauge hierarchy may be generated. 26 refs

  2. Numerical modelling dam break analysis for water supply project

    International Nuclear Information System (INIS)

    Dam provides many benefits to the society, but it can also cause extensive damage to downstream area when it fails. Dam failure can cause extensive damage to properties and loss of human life due to short warning time available. In general, dam spillway was designed to drain the maximum discharge from the dam during the Probable Maximum Flood (PMF). The spillway is functioned to prevent the dam from failure due to overtopping, which can lead to the dam failure. Dam failure will result in large volume of water travelling at very high velocity to the downstream area of the dam. It can cause extensive property damage, destruction of important facilities, and significant loss of human life along the way. Due to the potential of high hazard it poses to the downstream area, a dam break analysis is considered very essential. This paper focuses into the dam failure analysis for Kahang Dam by prediction of breach flow hydrographs and generation of inundation map at downstream area. From the PMF scenario simulation, the maximum inflow is 525.12 m3/s and peak discharge from the dam during dam failure is 6188m3/s. The results are able to provide information for preparation of Emergency Response Plan (PMF), in which appropriate steps can be taken by relevant authorities to avoid significant loss of human lives.

  3. A randomised controlled trial to prevent hospital readmissions and loss of functional ability in high risk older adults: a study protocol

    Directory of Open Access Journals (Sweden)

    Chang Anne M

    2011-08-01

    collection is undertaken at baseline within 72 hours of hospital admission, 4 weeks following hospital discharge, 12 weeks following hospital discharge, and 24 weeks following hospital discharge. Outcome assessors are blinded to group allocation. Primary outcomes are emergency hospital readmissions and health service use, functional status, psychosocial well-being and cost effectiveness. Discussion The acute hospital sector comprises the largest component of health care system expenditure in developed countries, and older adults are the most frequent consumers. There are few trials to demonstrate effective models of transitional care to prevent emergency readmissions, loss of functional ability and independence in this population following an acute hospital admission. This study aims to address that gap and provide information for future health service planning which meets client needs and lowers the use of acute care services. Trial Registration No Australian & New Zealand Clinical Trials Registry ACTRN12608000202369

  4. Break preclusion: an overview

    International Nuclear Information System (INIS)

    This paper is the result of an attempt to understand the frequently referred terms 'Break Preclusion' (BP) and 'Leak Before Break' (LBB) criteria in the safety literature and available relevant information on internet. Break Preclusion means exclusion of assumption of double ended guillotine rupture of pipelines and instead assuming leak before break which allows to use a reliable system for leak detection signal to shutdown the reactor before the pipe rupture occurs. In other words it means discovery of leak before fracture may occur in service. Pressure vessels and Piping of main steam lines are the areas of application of LBB. Early detection of leak enables shutdown of the reactor of the nuclear power plant. The information used for review are based on abstracts and/or concise form of papers available on internet. As early as in 1982 preclusion of double ended circumferential rupture of the main coolant line was attempted. Break preclusion concept, BPC and LBB both are based on high level knowledge of fracture mechanics. (author)

  5. Warped Supersymmetry Breaking

    CERN Document Server

    Burgess, C P; de Alwis, S P; Giddings, S B; Maharana, A; Quevedo, Fernando; Suruliz, K

    2008-01-01

    We address the size of supersymmetry-breaking effects within higher-dimensional settings where the observable sector resides deep within a strongly warped region, with supersymmetry breaking not necessarily localized in that region. Our particular interest is in how the supersymmetry-breaking scale seen by the observable sector depends on this warping. We obtain this dependence in two ways: by computing within the microscopic (string) theory supersymmetry-breaking masses in supermultiplets; and by investigating how warping gets encoded into masses within the low-energy 4D effective theory. We find that the lightest gravitino mode can have mass much less than the straightforward estimate from the mass shift of the unwarped zero mode. This lightest Kaluza-Klein excitation plays the role of the supersymmetric partner of the graviton and has a warped mass m_{3/2} proportional to e^A, with e^A the warp factor, and controls the size of the soft SUSY breaking terms. We formulate the conditions required for the exist...

  6. Electroweak symmetry breaking

    International Nuclear Information System (INIS)

    The Higgs mechanism is reviewed in its most general form, requiring the existence of a new symmetry-breaking force and associated particles, which need not however be Higgs bosons. The first lecture reviews the essential elements of the Higgs mechanism, which suffice to establish low energy theorems for the scattering of longitudinally polarized W and Z gauge bosons. An upper bound on the scale of the symmetry-breaking physics then follows from the low energy theorems and partial wave unitarity. The second lecture reviews particular models, with and without Higgs bosons, paying special attention to how the general features discussed in lecture 1 are realized in each model. The third lecture focuses on the experimental signals of strong WW scattering that can be observed at the SSC above 1 TeV in the WW subenergy, which will allow direct measurement of the strength of the symmetry-breaking force. 52 refs., 10 figs

  7. Experimental Research on the Dam-Break Mechanisms of the Jiadanwan Landslide Dam Triggered by the Wenchuan Earthquake in China

    Directory of Open Access Journals (Sweden)

    Fu-gang Xu

    2013-01-01

    Full Text Available Dam breaks of landslide dams are always accompanied by large numbers of casualties, a large loss of property, and negative influences on the downstream ecology and environment. This study uses the Jiadanwan landslide dam, created by the Wenchuan earthquake, as a case study example. Several laboratory experiments are carried out to analyse the dam-break mechanism of the landslide dam. The different factors that impact the dam-break process include upstream flow, the boulder effect, dam size, and channel discharge. The development of the discharge channel and the failure of the landslide dam are monitored by digital video and still cameras. Experimental results show that the upstream inflow and the dam size are the main factors that impact the dam-break process. An excavated discharge channel, especially a trapezoidal discharge channel, has a positive effect on reducing peak flow. The depth of the discharge channel also has a significant impact on the dam-break process. The experimental results are significant for landslide dam management and flood disaster prevention and mitigation.

  8. A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy. A secondary analysis

    International Nuclear Information System (INIS)

    The aim of this study was to determine the impact of bethanechol administration concomitant to radiotherapy (RT) on oral mucositis, candidiasis and taste loss. We performed a secondary analysis of a previously conducted prospective randomized trial which evaluated the effect of bethanechol on salivary gland dysfunction before, during, and after RT for head and neck cancer (HNC), in comparison to artificial saliva. Mucositis, candidiasis and taste loss were analyzed in 36 patients. Mucositis was scored using the World Health Organization (WHO) method; candidiasis was diagnosed by means of clinical examination, whereas taste loss was assessed by the patients' subjective report of absence of taste. No significant differences were observed between groups in relation to frequency and severity of mucositis or frequency of candidiasis and taste loss. In conclusion, bethanechol does not appear to reduce the incidence of mucositis, candidiasis, and taste loss when administered during RT. (author)

  9. Routinizing Breaking News

    DEFF Research Database (Denmark)

    Hartley, Jannie Møller

    2011-01-01

    This chapter revisits seminal theoretical categorizations of news proposed three decades earlier by US sociologist Gaye Tuchman. By exploring the definition of ”breaking news” in the contemporary online newsrooms of three Danish news organisations, the author offers us a long overdue re-theorizat...

  10. Breaking the Waves

    DEFF Research Database (Denmark)

    Christensen, Poul Rind; Kirketerp, Anne

    2006-01-01

    The paper shortly reveals the history of a small school - the KaosPilots - dedicated to educate young people to carriers as entrepreneurs. In this contribution we want to explore how the KaosPilots managed to break the waves of institutionalised concepts and practices of teaching entrepreneurship...

  11. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  12. High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting.

    OpenAIRE

    Manzi, M; Zachariah, R.; Teck, R; Buhendwa, L.; Kazima, J.; Bakali, E; Firmenich, Peter; Humblet, P

    2005-01-01

    SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: In a prevention of mother-to-child HIV transmission (PMTCT) programme, to determine: the acceptability of offering 'opt-out' voluntary counselling and HIV-testing (VCT); the progressive loss to follow up of HIV-positive mothers during the antenatal period, at delivery and to the 6-month postnatal visit; and the proportion of missed deliveries in the district. DESIGN: Cohort study. METHODS: Review of routine antenatal, VCT and PMTCT ...

  13. "PARAMETERS AFFECTING NOISE INDUCED HEARING LOSS IN INDUSTRY"

    Directory of Open Access Journals (Sweden)

    D. Parvizpour

    1977-09-01

    Full Text Available The paper is based on a study conducted in three different industries on 84.4 on their employees to determine the effect of over all noise intensity, length of employment and rest periods among them. It was found that the mentioned factors have direct effect on the induced hearing loss among the exposed workers. High noise level and long period of employment adversely affect the hearing ability while the breaks taken during daily working hours have prevented the expected defect.

  14. The Preventive Effect of Biochanin A on Bone Loss in Ovariectomized Rats: Involvement in Regulation of Growth and Activity of Osteoblasts and Osteoclasts

    OpenAIRE

    Shu-Jem Su; Yao-Tsung Yeh; Huey-Wen Shyu

    2013-01-01

    Biochanin A (BCA) is a major isoflavone abundant in red clover (Trifolium pretense). The protective effect of BCA on bone loss in an ovariectomized (OVX) animal model has never been clarified. The objective of this study was to investigate the biological effects of BCA on bone loss in OVX rats in vivo and on the development of osteoblasts and osteoclasts in vitro. Ovariectomy resulted in a marked increase in body weight and a decrease in femoral bone mineral density and trabecular bone volume...

  15. Short-term, daily exposure to cold temperature may be an efficient way to prevent muscle atrophy and bone loss in a microgravity environment

    OpenAIRE

    Deng, Claudia; Wang, Ping; Zhang, Xiangming; Wang, Ya

    2015-01-01

    Microgravity induces less pressure on muscle/bone, which is a major reason for muscle atrophy as well as bone loss. Currently, physical exercise is the only countermeasure used consistently in the U.S. human space program to counteract the microgravity-induced skeletal muscle atrophy and bone loss. However, the routinely almost daily time commitment is significant and represents a potential risk to the accomplishment of other mission operational tasks. Therefore, development of more efficient...

  16. Bayesian Belief Networks for predicting drinking water distribution system pipe breaks

    International Nuclear Information System (INIS)

    In this paper, we use Bayesian Belief Networks (BBNs) to construct a knowledge model for pipe breaks in a water zone. To the authors’ knowledge, this is the first attempt to model drinking water distribution system pipe breaks using BBNs. Development of expert systems such as BBNs for analyzing drinking water distribution system data is not only important for pipe break prediction, but is also a first step in preventing water loss and water quality deterioration through the application of machine learning techniques to facilitate data-based distribution system monitoring and asset management. Due to the difficulties in collecting, preparing, and managing drinking water distribution system data, most pipe break models can be classified as “statistical–physical” or “hypothesis-generating.” We develop the BBN with the hope of contributing to the “hypothesis-generating” class of models, while demonstrating the possibility that BBNs might also be used as “statistical–physical” models. Our model is learned from pipe breaks and covariate data from a mid-Atlantic United States (U.S.) drinking water distribution system network. BBN models are learned using a constraint-based method, a score-based method, and a hybrid method. Model evaluation is based on log-likelihood scoring. Sensitivity analysis using mutual information criterion is also reported. While our results indicate general agreement with prior results reported in pipe break modeling studies, they also suggest that it may be difficult to select among model alternatives. This model uncertainty may mean that more research is needed for understanding whether additional pipe break risk factors beyond age, break history, pipe material, and pipe diameter might be important for asset management planning. - Highlights: • We show Bayesian Networks for predictive and diagnostic management of water distribution systems. • Our model may enable system operators and managers to prioritize system

  17. Incompatibility breaking quantum channels

    International Nuclear Information System (INIS)

    A typical bipartite quantum protocol, such as EPR-steering, relies on two quantum features, entanglement of states and incompatibility of measurements. Noise can delete both of these quantum features. In this work we study the behavior of incompatibility under noisy quantum channels. The starting point for our investigation is the observation that compatible measurements cannot become incompatible by the action of any channel. We focus our attention to channels which completely destroy the incompatibility of various relevant sets of measurements. We call such channels incompatibility breaking, in analogy to the concept of entanglement breaking channels. This notion is relevant especially for the understanding of noise-robustness of the local measurement resources for steering. (paper)

  18. Breaking News as Radicalisation

    DEFF Research Database (Denmark)

    Hartley, Jannie Møller

    The aim of the paper is to make explicit how the different categories are applied in the online newsroom and thus how new categories can be seen as positioning strategies in the form of radicalisations of already existing categories. Thus field theory provides us with tools to analyse how online...... journalists are using the categorisations to create hierarchies within the journalistic field in order to position themselves as specialists in what Tuchman has called developing news, aiming and striving for what today is know as breaking news and the “exclusive scoop,” as the trademark of online journalism...... in a media environment where immediacy rules (Domingo 2008a). Following this research the primary focus of this paper is the category breaking news and Tuchmans developing news, but as they are all connected the analysis will also draw upon the other categories in Tuchmans typology. The theoretical...

  19. Dynamical Electroweak Symmetry Breaking

    Czech Academy of Sciences Publication Activity Database

    Hošek, Jiří; Smetana, Adam

    Berlin: Springer, 2014, s. 17-28. ISBN 978-3-319-07072-8 R&D Projects: GA ČR GA202/06/0734; GA MŠk LA08015; GA MŠk LA08032 Institutional support: RVO:61389005 Keywords : dynamical electroweak symmetry breaking * top-quark condensation * neutriono condensation * strong Yukawa dynamics * flavor gauge dynamics Subject RIV: BE - Theoretical Physics

  20. Predicting appointment breaking.

    Science.gov (United States)

    Bean, A G; Talaga, J

    1995-01-01

    The goal of physician referral services is to schedule appointments, but if too many patients fail to show up, the value of the service will be compromised. The authors found that appointment breaking can be predicted by the number of days to the scheduled appointment, the doctor's specialty, and the patient's age and gender. They also offer specific suggestions for modifying the marketing mix to reduce the incidence of no-shows. PMID:10142384

  1. On the symmetry breaking phenomenon

    OpenAIRE

    Birtea, Petre; Puta, Mircea; Ratiu, Tudor S.; Tudoran, Ruazvan Micu

    2006-01-01

    We investigate the problem of symmetry breaking in the framework of dynamical systems with symmetry on a smooth manifold. Two cases will be analyzed: general and Hamiltonian dynamical systems. We give sufficient conditions for symmetry breaking in both cases.

  2. Role of Double-Strand Break End-Tethering during Gene Conversion in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Suvi Jain

    2016-04-01

    Full Text Available Correct repair of DNA double-strand breaks (DSBs is critical for maintaining genome stability. Whereas gene conversion (GC-mediated repair is mostly error-free, repair by break-induced replication (BIR is associated with non-reciprocal translocations and loss of heterozygosity. We have previously shown that a Recombination Execution Checkpoint (REC mediates this competition by preventing the BIR pathway from acting on DSBs that can be repaired by GC. Here, we asked if the REC can also determine whether the ends that are engaged in a GC-compatible configuration belong to the same break, since repair involving ends from different breaks will produce potentially deleterious translocations. We report that the kinetics of repair are markedly delayed when the two DSB ends that participate in GC belong to different DSBs (termed Trans compared to the case when both DSB ends come from the same break (Cis. However, repair in Trans still occurs by GC rather than BIR, and the overall efficiency of repair is comparable. Hence, the REC is not sensitive to the "origin" of the DSB ends. When the homologous ends for GC are in Trans, the delay in repair appears to reflect their tethering to sequences on the other side of the DSB that themselves recombine with other genomic locations with which they share sequence homology. These data support previous observations that the two ends of a DSB are usually tethered to each other and that this tethering facilitates both ends encountering the same donor sequence. We also found that the presence of homeologous/repetitive sequences in the vicinity of a DSB can distract the DSB end from finding its bona fide homologous donor, and that inhibition of GC by such homeologous sequences is markedly increased upon deleting Sgs1 but not Msh6.

  3. A synopsis of experimental activities on small-break LOCA

    International Nuclear Information System (INIS)

    Through reactor safety studies like WASH 1400 or the ''Deutsche Risiko-Studie'' the attention has turned from large break loss of coolant accidents to small breaks because of the high contribution of this type of accidents to core meltdown. But only after the TMI-2 accident were also the main activities in the experimental fields shifted world-wide to the small break LOCAs. Since TMI numerous research programs have either been finished or are underway. This review paper presents: a classification of the various types of transients according to break size; a discussion of major physical phenomena associated with a small break LOCA, and a description of a few selected research programs and the most important results achieved. (author)

  4. Weight Loss and the Prevention of Weight Regain: Evaluation of a Treatment Model of Exercise Self-Regulation Generalizing to Controlled Eating

    Science.gov (United States)

    Annesi, James J; Johnson, Ping H; Tennant, Gisèle A; Porter, Kandice J; McEwen, Kristin L

    2016-01-01

    Context: For decades, behavioral weight-loss treatments have been unsuccessful beyond the short term. Development and testing of innovative, theoretically based methods that depart from current failed practices is a priority for behavioral medicine. Objective: To evaluate a new, theory-based protocol in which exercise support methods are employed to facilitate improvements in psychosocial predictors of controlled eating and sustained weight loss. Methods: Women with obesity were randomized into either a comparison treatment that incorporated a print manual plus telephone follow-ups (n = 55) or an experimental treatment of The Coach Approach exercise-support protocol followed after 2 months by group nutrition sessions focused on generalizing self-regulatory skills from an exercise support to a controlled eating context (n = 55). Repeated-measures analysis of variance contrasted group changes in weight, physical activity, fruit and vegetable intake, mood, and exercise- and eating-related self-regulation and self-efficacy over 24 months. Regression analyses determined salient interrelations of change scores over both the weight-loss phase (baseline-month 6) and weight-loss maintenance phase (month 6-month 24). Results: Improvements in all psychological measures, physical activity, and fruit and vegetable intake were significantly greater in the experimental group where a mean weight loss of 5.7 kg (6.1% of initial body weight) occurred at month 6, and was largely maintained at a loss of 5.1 kg (5.4%) through the full 24 months of the study. After establishing temporal intervals for changes in self-regulation, self-efficacy, and mood that best predicted improvements in physical activity and eating, a consolidated multiple mediation model suggested that change in self-regulation best predicted weight loss, whereas change in self-efficacy best predicted maintenance of lost weight. Conclusions: Because for most participants loss of weight remained greater than that

  5. Simulation of a large break loss of coolant (LBLOCA), without actuation of the emergency injection systems (ECCS) for a BWR-5; Simulacion de un escenario de perdida de refrigerante grande (LBLOCA), sin actuacion de los sistemas de inyeccion de emergencia (ECCS) para un reactor BWR-5

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas V, J.; Mugica R, C. A.; Lopez M, R., E-mail: jaime.cardenas@cnsns.gob.mx [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan 779, Col. Narvarte, 03020 Ciudad de Mexico (Mexico)

    2015-09-15

    In this paper the analysis of scenario for the loss of coolant case was realized with break at the bottom of a recirculation loop of a BWR-5 with containment type Mark II and a thermal power of 2317 MWt considering that not have coolant injection. This in order to observe the speed of progression of the accident, the phenomenology of the scenario, the time to reach the limit pressure of containment venting and the amount of radionuclides released into the environment. This simulation was performed using the MELCOR code version 2.1. The scenario posits a break in one of the shear recirculation loops. The emergency core cooling system (ECCS) and the reactor core isolation cooling (Rcic) have not credit throughout the event, which allowed achieve greater severity on scenario. The venting of the primary containment was conducted via valve of 30 inches instead of the line of 24 inches of wet well, this in order to have a larger area of exhaust of fission products directly to the reactor building. The venting took place when the pressure in the primary containment reached the 4.5 kg/cm{sup 2} and remained open for the rest of the scenario to maximize the amount released of radionuclides to the atmosphere. The safety relief valves were considered functional they do not present mechanical failure or limit their ability to release pressure due to the large number of performances in safety mode. The results of the analysis covers about 48 hours, time at which the accident evolution was observed; behavior of level, pressure in the vessel and the fuel temperature profile was analyzed. For progression of the scenario outside the vessel, the pressure and temperature of the primary containment, level and temperature of the suppression pool, the hydrogen accumulation in the container and the radionuclides mass released into the atmosphere were analyzed. (Author)

  6. Spontaneous symmetry breaking, self-trapping, and Josephson oscillations

    CERN Document Server

    2013-01-01

    This volume collects a a number of contributions on spontaneous symmetry breaking. Current studies in this general field are going ahead at a full speed. The book present review chapters which give an overview on the major break throughs of recent years. It covers a number of different physical settings which are introduced when a nonlinearity is added to the underlying symmetric problems and its strength exceeds a certain critical value. The corresponding loss of symmetry, called spontaneous symmetry breaking, alias self-trapping into asymmetric states is extensively discussed in this book.

  7. Break the Pattern!

    DEFF Research Database (Denmark)

    Hasse, Cathrine; Trentemøller, Stine

    Break the Pattern! A critical enquiry into three scientific workplace cultures: Hercules, Caretakers and Worker Bees is the third publication of the international three year long project "Understanding Puzzles in the Gendered European Map" (UPGEM). By contrasting empirical findings from academic...... workplaces in the five UPGEM-countries (Denmark, Estonia, Finland, Italy and Poland) we identify three clusters of cultural patterns in physics as culture. We call these Hercules, Caretakers and Worker Bees. We also consider the influence of national cultural historical processes on the scientific culture...

  8. Symmetries and Symmetry Breaking

    CERN Document Server

    Van Oers, W T H

    2003-01-01

    In understanding the world of matter, the introduction of symmetry principles following experimentation or using the predictive power of symmetry principles to guide experimentation is most profound. The conservation of energy, linear momentum, angular momentum, charge, and CPT involve fundamental symmetries. All other conservation laws are valid within a restricted subspace of the four interactions: the strong, the electromagnetic, the weak, and the gravitational interaction. In this paper comments are made regarding parity violation in hadronic systems, charge symmetry breaking in two nucleon and few nucleon systems, and time-reversal-invariance in hadronic systems.

  9. Breaking the Silence

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Many women who suffer from vaginitis have kept silent about their illness because they think it is shameful to have such a disease. The International Women’s Health Coalition (IWHC) has publicized the problem, referring to it as a "culture of silence"inherited from traditional thinking. The coalition has made attempts to improve women’s health conditions by changing people’s misconceptions about the disease. In 1997, under a grant from the American Ford Foundation, the Sichuan Provincial Women’s Federation carried out a study on women’s repro-ductive health, aimed at "breaking the silence."

  10. Thinking of change in terms of gains or losses Promotion versus prevention focus as a moderator in the job demands-resources model

    Directory of Open Access Journals (Sweden)

    Paraskevas Petrou

    2010-12-01

    Full Text Available Orientation: Promotion and prevention regulatory foci have been established as self-regulation systems with implications for the study of change.Research purpose: The study aimed to test moderating effects of promotion and prevention focus within the job demands-resources model in a context of organisational change. Predictors included job demands and resources whilst outcomes included emotional exhaustion, disengagement and openness to change.Motivation for the study: The study intended to understand whether individual differences in promotion and prevention focus play an important role during the experience of organisational change.Research design, approach and method: A sample of 164 teachers from the Netherlands participated in a quantitative survey design before a new governmental policy was implemented in their schools and 189 different teachers working in the same schools participated in the survey after the implementation of the policy. Cross-sectional moderated regression analyses were used to analyse the data.Main findings: Promotion focus moderated the relationship between job demands and openness to change, whilst both promotion and prevention focus moderated many of the relationships between job resources on the one hand and emotional exhaustion, disengagement and openness to change on the other hand.Practical/managerial implications: Knowing that organisational change can have different meanings for promotion and prevention focused employees, managers can facilitate employee adaptation to change.Contribution/value-add: This research provides a theoretical framework that incorporates self-regulation as a moderator in the job demands-resources model. At the same time, implications for organisational change were co-examined.

  11. RELAP5/MOD3.3程序对非能动核电厂小破口失水事故的适用性研究%Applicability Research of RELAP5/MOD3.3 for Small Break Loss of Coolant Accident of NPP With Passive Safety System

    Institute of Scientific and Technical Information of China (English)

    徐财红; 史国宝

    2014-01-01

    AP1000核电厂采用非能动堆芯冷却系统来缓解小破口失水事故(SBLOCA),缓解事故的理念是流动冷却。RELAP5/MOD3.3程序适用于传统核电厂SBLOCA 研究,对于非能动电厂SBLOCA研究的适用性需重新研究与评估。本工作基于非能动电厂小破口失水事故的分析,结合RELAP5/MOD3.3的结构与模型,对其进行评估和改进。为验证改进后的REL A P5/M OD3.3的适用性,以A P1000小破口失水事故的验证试验台架APEX-1000为模拟对象,分析模拟DBA-02、NRC-05事故工况。分析结果表明,改进后的REL A P5/M OD3.3的计算结果与试验数据符合较好。%The passive core cooling system is used in AP 1000 to mitigate the small break loss of coolant accident (SBLOCA) .The RELAP5/MOD3.3 code is generally applicable to the traditional NPP SBLOCA research , but for the passive NPP SBLOCA , its applicability will need further study and evaluation . Based on the analysis of the important phenomenon of the SBLOCA of the passive NPP , the RELAP5/MOD3.3 code was assessed and modified . In order to verify the applicability of the modified RELAP5/MOD3.3 code ,the DBA-02 and NRC-05 cases of APEX-1000 which was the test facility for verifying AP1000 small break loss of coolant accident ,were simulated . It shows good agreement between the results of the modified RELAP5/MOD3.3 code and experiment data .

  12. Radionuclide Release after LBLOCA with Loss of Class IV Power Accident in CANDU-6 Plant

    International Nuclear Information System (INIS)

    A large break in a pipe train of a primary heat transport system discharges coolant, which has high energy and large mass, into the containment building. Reactor shutdown and emergency core cooling water will limit the fuel cladding failure, but cannot prevent it entirely. The containment building is the last barrier of radionuclide release to the environment. Containment isolation and pressure suppression by dousing and local air cooler reduce the amount of radionuclide release to the environment. The objective of containment behavior analysis for large break loss of coolant with loss of class IV power accident is to assess the amount of radionuclide release to the ambient atmosphere. Radionuclide release rates in this event, with all safety system available, that is, the containment building is intact, as well as with containment system impairment, are analyzed with GOTHIC and SMART code

  13. Radionuclide Release after LBLOCA with Loss of Class IV Power Accident in CANDU-6 Plant

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hoon [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2011-10-15

    A large break in a pipe train of a primary heat transport system discharges coolant, which has high energy and large mass, into the containment building. Reactor shutdown and emergency core cooling water will limit the fuel cladding failure, but cannot prevent it entirely. The containment building is the last barrier of radionuclide release to the environment. Containment isolation and pressure suppression by dousing and local air cooler reduce the amount of radionuclide release to the environment. The objective of containment behavior analysis for large break loss of coolant with loss of class IV power accident is to assess the amount of radionuclide release to the ambient atmosphere. Radionuclide release rates in this event, with all safety system available, that is, the containment building is intact, as well as with containment system impairment, are analyzed with GOTHIC and SMART code

  14. Spontaneous breaking of supersymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Zumino, B.

    1981-12-01

    There has been recently a revival of interest in supersymmetric gauge theories, stimulated by the hope that supersymmetry might help in clarifying some of the questions which remain unanswered in the so called Grand Unified Theories and in particular the gauge hierarchy problem. In a Grand Unified Theory one has two widely different mass scales: the unification mass M approx. = 10/sup 15/GeV at which the unification group (e.g. SU(5)) breaks down to SU(3) x SU(2) x U(1) and the mass ..mu.. approx. = 100 GeV at which SU(2) x U(1) is broken down to the U(1) of electromagnetism. There is at present no theoretical understanding of the extreme smallness of the ratio ..mu../M of these two numbers. This is the gauge hierarchy problem. This lecture attempts to review the various mechanisms for spontaneous supersymmetry breaking in gauge theories. Most of the discussions are concerned with the tree approximation, but what is presently known about radiative correction is also reviewed.

  15. Bootstrap Dynamical Symmetry Breaking

    Directory of Open Access Journals (Sweden)

    Wei-Shu Hou

    2013-01-01

    Full Text Available Despite the emergence of a 125 GeV Higgs-like particle at the LHC, we explore the possibility of dynamical electroweak symmetry breaking by strong Yukawa coupling of very heavy new chiral quarks Q . Taking the 125 GeV object to be a dilaton with suppressed couplings, we note that the Goldstone bosons G exist as longitudinal modes V L of the weak bosons and would couple to Q with Yukawa coupling λ Q . With m Q ≳ 700  GeV from LHC, the strong λ Q ≳ 4 could lead to deeply bound Q Q ¯ states. We postulate that the leading “collapsed state,” the color-singlet (heavy isotriplet, pseudoscalar Q Q ¯ meson π 1 , is G itself, and a gap equation without Higgs is constructed. Dynamical symmetry breaking is affected via strong λ Q , generating m Q while self-consistently justifying treating G as massless in the loop, hence, “bootstrap,” Solving such a gap equation, we find that m Q should be several TeV, or λ Q ≳ 4 π , and would become much heavier if there is a light Higgs boson. For such heavy chiral quarks, we find analogy with the π − N system, by which we conjecture the possible annihilation phenomena of Q Q ¯ → n V L with high multiplicity, the search of which might be aided by Yukawa-bound Q Q ¯ resonances.

  16. Do organisations in the UK have a legal right to implement Data Loss Prevention technology with respect to employee’s personal devices?

    OpenAIRE

    Greenwell, Joel

    2013-01-01

    There are two technology paradigms that have become predominant within the past few years, which are converging upon each other much like two huge cargo ships, “Data Loss Prevention” (DLP) and “Bring your own Device” (BYOD). Understanding the legal implications of such a convergence is important to ensure organisations don’t become exposed themselves to potential legal difficulties. Starting with a brief introduction to DLP and BYOD, explaining their history and what they are, this dissert...

  17. Transiently Increasing cAMP Levels Selectively in Hippocampal Excitatory Neurons during Sleep Deprivation Prevents Memory Deficits Caused by Sleep Loss

    OpenAIRE

    Havekes, Robbert; Bruinenberg, Vibeke M.; Tudor, Jennifer C; Ferri, Sarah L.; Baumann, Arnd; Meerlo, Peter; Abel, Ted

    2014-01-01

    The hippocampus is particularly sensitive to sleep loss. Although previous work has indicated that sleep deprivation impairs hippocampal cAMP signaling, it remains to be determined whether the cognitive deficits associated with sleep deprivation are caused by attenuated cAMP signaling in the hippocampus. Further, it is unclear which cell types are responsible for the memory impairments associated with sleep deprivation. Transgenic approaches lack the spatial resolution to manipulate specific ...

  18. Would Border Carbon Adjustments prevent carbon leakage and heavy industry competitiveness losses? Insights from a meta-analysis of recent economic studies

    OpenAIRE

    Branger, Frédéric; Quirion, Philippe

    2013-01-01

    The efficiency of unilateral climate policies may be hampered by carbon leakage and competitiveness losses. A widely discussed policy option to reduce leakage and protect competitiveness of heavy industries is to impose Border Carbon Adjustments (BCA) to non regulated countries, which remains contentious for juridical and political reasons. The estimation of carbon leakage as well as the assessment of different policy options led to a substantial body of litterature in energy-economic modelin...

  19. Recovery of reticulocytes and prevention of radiation-induced weight loss in mice by γ-tocotrienol: possible application to cancer therapy

    International Nuclear Information System (INIS)

    Gamma-tocotrienol (GT), an alpha-tocopherol (AT, vitamin E) isomer was found to be better than AT against radiation-induced lethality. CD2F1 male mice (LD 50/30 radiation dose 9 Gy) were injected subcutaneously with 10 mg/mouse each of GT or AT. After 24 hrs, mice were given 11 Gy 60 Cobalt radiation. All mice treated with AT survived; only 50% of the mice treated with GT survived. The mechanism of protection may not involve apoptotic pathway since GT did not affect caspase-3 activity whereas AT suppressed radiation-induced increase in activity. Recovery profiles of blood cells and weight loss were also evaluated. Mice were treated with AT, GT, or vehicle prior to sublethal whole-body gamma irradiation. In the AT- and GT-treated mice, the recovery rates of neutrophils, platelets, erythrocytes, and reticulocytes were greater than in vehicle-treated controls. The highest level (265% of the normal) of reticulocytes in GT or AT treated mice was reached in 15 days postirradiation; the highest level (450% of the normal) in vehicle-treated controls was reached 20 days after irradiation. Recovery profile of erythrocytes suggested that reticulocytes in the irradiated controls matured slowly into erythrocytes; reticulocytes in GT or AT treated mice matured at a faster rate. Radiation-induced weight loss was studied at a supralethal dose of 10.5 Gy. All animals, irrespective of the treatments lost up to 20% weight in 5 days. After a transient increase, irradiated controls and AT-treated mice continued to decline in weight (13 to 17%) till day 16 after irradiation. GT-treated mice lost only 1% to 9% after the initial loss in 5 days. These studies indicate that GT may be preferable than AT not only as a non-toxic radiation protective agent but also as an ideal adjuvant in alleviating anemia and weight loss accompanying radiotherapy or chemotherapy of cancer

  20. Rotation Breaking Induced by ELMs on EAST

    DEFF Research Database (Denmark)

    Xiong, H.; Xu, G.; Sun, Y.;

    Spontaneous rotation has been observed in LHCD H-mode plasmas with type III ELMs (edge localized modes) on EAST, and it revealed that type III ELMs can induce the loss of both core and edge toroidal rotation. Here we work on the breaking mechanism during the ELMs. Several large tokamaks have...... of magnetic surface, thus generate NTV (neoclassical toroidal viscosity) torque that affects toroidal rotation. We adopt 1cm maximum edge magnetic surface displacement from experimental observation, and our calculation shows that the edge torque is about 0.35 N/m2, and the core very small. The...... expected angular momentum density change is about 3.8 N/m2, nearly 10 times larger than the calculation. Previous work on EAST has suggested that there is a mechanism at the edge that breaks the rotation, while the core rotation change is mostly likely related with momentum transport to the edge. In other...

  1. Relationship between Age and the Ability to Break Scored Tablets

    Science.gov (United States)

    Notenboom, Kim; Vromans, Herman; Schipper, Maarten; Leufkens, Hubert G. M.; Bouvy, Marcel L.

    2016-01-01

    Background: Practical problems with the use of medicines, such as difficulties with breaking tablets, are an often overlooked cause for non-adherence. Tablets frequently break in uneven parts and loss of product can occur due to crumbling and powdering. Health characteristics, such as the presence of peripheral neuropathy, decreased grip strength and manual dexterity, can affect a patient's ability to break tablets. As these impairments are associated with aging and age-related diseases, such as Parkinson's disease and arthritis, difficulties with breaking tablets could be more prevalent among older adults. The objective of this study was to investigate the relationship between age and the ability to break scored tablets. Methods: A comparative study design was chosen. Thirty-six older adults and 36 young adults were systematically observed with breaking scored tablets. Twelve different tablets were included. All participants were asked to break each tablet by three techniques: in between the fingers with the use of nails, in between the fingers without the use of nails and pushing the tablet downward with one finger on a solid surface. It was established whether a tablet was broken or not, and if broken, whether the tablet was broken accurately or not. Results: The older adults experienced more difficulties to break tablets compared to the young adults. On average, the older persons broke 38.1% of the tablets, of which 71.0% was broken accurately. The young adults broke 78.2% of the tablets, of which 77.4% was broken accurately. Further analysis by mixed effects logistic regression revealed that age was associated with the ability to break tablets, but not with the accuracy of breaking. Conclusions: Breaking scored tablets by hand is less successful in an elderly population compared to a group of young adults. Health care providers should be aware that tablet breaking is not appropriate for all patients and for all drugs. In case tablet breaking is unavoidable, a

  2. Azithromycin Prevents Pregnancy Loss: Reducing the Level of Tumor Necrosis Factor-Alpha and Raising the Level of Interleukin-10 in Rats

    OpenAIRE

    Ayse Er

    2013-01-01

    The aim of this study was to determine the effect of azithromycin on LPS-induced pregnancy loss. Thirty-six pregnant female Wistar rats were divided into 4 equal groups as follows: control group, where 0.3 mL of normal saline solution was administered intravenously on day 10 of pregnancy; azithromycin group, where azithromycin was administered orally at 350 mg kg−1 day on days 9, 10, and 11 of pregnancy; lipopolysaccharide group, where LPS was administered intravenously via the tail vein at 1...

  3. Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevents Bone Loss in Ovariectomized Nude Mice

    OpenAIRE

    An, Jee Hyun; Park, Hyojung; Song, Jung Ah; Ki, Kyung Ho; Yang, Jae-Yeon; Choi, Hyung Jin; Cho, Sun Wook; Kim, Sang Wan; Kim, Seong Yeon; Yoo, Jeong Joon; Baek, Wook-Young; Kim, Jung-Eun; Choi, Soo Jin; Oh, Wonil; Shin, Chan Soo

    2013-01-01

    Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in stem cell therapy. We studied the effects of systemic injection of human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss in nude mice. Ten-week-old female nude mice were divided into six groups: Sham-operated mice treated with vehicle (Sham-Vehicle), OVX mice subjected to UCB-MSCs (OVX-MSC), or human dermal fibroblast (OVX-DFB) transplantation, ...

  4. Violent breaking wave impacts

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Peregrine, D.H.; Bullock, G.N.

    2009-01-01

    When an ocean wave breaks against a steep-fronted breakwater, sea wall or a similar marine structure, its impact on the structure can be very violent. This paper describes the theoretical studies that, together with field and laboratory investigations, have been carried out in order to gain a...... better understanding of the processes involved. The wave's approach towards a structure is modelled with classical irrotational flow to obtain the different types of impact profiles that may or may not lead to air entrapment. The subsequent impact is modelled with a novel compressible-flow model for a...... homogeneous mixture of incompressible liquid and ideal gas. This enables a numerical description of both trapped air pockets and the propagation of pressure shock waves through the aerated water. An exact Riemann solver is developed to permit a finite-volume solution to the flow model with smallest possible...

  5. Investigation of break orientation effect during cold leg small-break LOCA at ROSA-IV LSTF

    International Nuclear Information System (INIS)

    The Large Scale Test Facility (LSTF) of the Rig-of-Safety Assessment No. 4 (ROSA-IV) Program is a volumetrically scaled (1/48) pressurized water reactor (PWR) system with an electrically heated core used for integral simulation of small break loss-of-coolant accidents (SBLOCAs) and operational transients. Three 2.5 % cold-leg SBLOCA experiments were conducted at LSTF. In the experiments, the break was oriented at the side, bottom and top of the horizontal cold leg, respectively. The loop seal clearing in the bottom break case was later than in the side break case since a larger amount of liquid had to be discharged until the loop seal clearing. The loop seal clearing in the top break case was later than in the side break case because of the smaller discharge flow rate. The core liquid level drop due to boiloff after the loop seal clearing in the bottom break case was earliest among three cases because of the largest mass loss before the loop seal clearing and in the top break case latest because of the latest occurrence of the loop seal clearing. However, the effect on the system transients such as the pressure and core liquid level transients was small since the transient time was quite long. Analyses to the experimental results were performed with the RELAP5/MOD2 code. Shortcomings in the RELAP5 code calculation results were resolved by reducing the interfacial drag in the hot leg and the core. The inclusion of Shrock's model for the side, bottom and top break of a large horizontal pipe was also tested in the analyses. However, consistent results with data were not obtained since the void fraction in the broken cold leg was not calculated properly. (author)

  6. Electroweak breaking in supersymmetric models

    CERN Document Server

    Ibáñez, L E

    1992-01-01

    We discuss the mechanism for electroweak symmetry breaking in supersymmetric versions of the standard model. After briefly reviewing the possible sources of supersymmetry breaking, we show how the required pattern of symmetry breaking can automatically result from the structure of quantum corrections in the theory. We demonstrate that this radiative breaking mechanism works well for a heavy top quark and can be combined in unified versions of the theory with excellent predictions for the running couplings of the model. (To be published in ``Perspectives in Higgs Physics'', G. Kane editor.)

  7. Break down of losses in thin electrolyte SOFCs

    DEFF Research Database (Denmark)

    Barfod, Rasmus; Hagen, Anke; Ramousse, S.; Hendriksen, P.V.; Mogensen, Mogens Bjerg

    2006-01-01

    /YSZ cermet anode, and a LSM composite cathode. Additional, qualitative information was obtained using symmetric cells with LSM composite electrodes. The investigations were carried out in the temperature interval from 700 to 850 degrees C. The electrolyte and anode activation energies obtained were 0.9 and 1...

  8. Breaking Barriers in Polymer Additive Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Love, Lonnie J [ORNL; Duty, Chad E [ORNL; Post, Brian K [ORNL; Lind, Randall F [ORNL; Lloyd, Peter D [ORNL; Kunc, Vlastimil [ORNL; Peter, William H [ORNL; Blue, Craig A [ORNL

    2015-01-01

    Additive Manufacturing (AM) enables the creation of complex structures directly from a computer-aided design (CAD). There are limitations that prevent the technology from realizing its full potential. AM has been criticized for being slow and expensive with limited build size. Oak Ridge National Laboratory (ORNL) has developed a large scale AM system that improves upon each of these areas by more than an order of magnitude. The Big Area Additive Manufacturing (BAAM) system directly converts low cost pellets into a large, three-dimensional part at a rate exceeding 25 kg/h. By breaking these traditional barriers, it is possible for polymer AM to penetrate new manufacturing markets.

  9. Thefts, break-ins, etc.

    CERN Multimedia

    Property Protection Group

    2004-01-01

    TAKING PRECAUTIONS IS THE BEST MEANS OF PROTECTION On the eve of CERN's annual end of year closure, it is in your own interest, that of your colleagues and that of the Organization, that the following recommendations be followed: 1. MONEY, VALUABLES & KEYS: Do not leave money or valuables in your office or your lockers. Keys and their copies should be removed or kept in a safe place. 2. DOORS & WINDOWS: Lock office, workshop, meeting-room doors etc. when you leave. Also close the windows if they are easily accessible from outside. 3. REPORTING INCIDENTS: Each crime solved could prevent another from being perpetrated. Please report any thefts, losses, objects gone missing and other incidents to the CERN Fire Brigade (tel. 74848) and keep them informed of any important developments (objects found, new clues, suspicious people or vehicles etc.). The Property Protection Group would like to wish you a Merry Christmas and a Happy New Year! Property Protection Group Tel. 72848

  10. R-parity breaking phenomenology

    International Nuclear Information System (INIS)

    We review various features of the R-parity breaking phenomenology, with particular attention to the low energy observables, and to the patterns of the R-parity breaking interactions that arise in Grand Unified models. (author). 22 refs, 1 fig., 3 tabs

  11. On partially entanglement breaking channels

    OpenAIRE

    Chruściński, Dariusz; Kossakowski, Andrzej

    2005-01-01

    Using well known duality between quantum maps and states of composite systems we introduce the notion of Schmidt number of a quantum channel. It enables one to define classes of quantum channels which partially break quantum entanglement. These classes generalize the well known class of entanglement breaking channels.

  12. Entanglement–breaking indices

    International Nuclear Information System (INIS)

    We study a set of new functionals (called entanglement–breaking indices) which characterize how many local iterations of a given (local) quantum channel are needed in order to completely destroy the entanglement between the system of interest over which the transformation is defined and an external ancilla. The possibility of contrasting the noisy effects introduced by the channel iterations via the action of intermediate (filtering) transformations is analyzed. We provide some examples in which our functionals can be exactly calculated. The differences between unitary and non-unitary filtering operations are analyzed showing that, at least for systems of dimension d larger than or equal to 3, the non-unitary choice is preferable (the gap between the performances of the two cases being divergent in some cases). For d = 2 (qubit case), on the contrary, no evidences of the presence of such gap is revealed: we conjecture that for this special case unitary filtering transformations are optimal. The scenario in which more general filtering protocols are allowed is also discussed in some detail. The case of a depolarizing noise acting on a two–qubit system is exactly solved in a general case

  13. Breaking the silence.

    Science.gov (United States)

    Dougherty, S

    1997-11-01

    Venezuela's Accion Solidaria and other non-governmental organizations are set to launch the country's first HIV prevention and education effort. In addition to the $7 million campaign, activists in the country have seen a number of recent successes. Accion Solidaria has been successfully incorporated into a nonprofit group in the United States, called Action of Solidarity. Other successes include the First National Venezuelan Meeting of People Living with HIV and AIDS to be held in mid-October, and the upcoming launch of Venezuela's first AIDS hotline. The hotline, part of the education and prevention campaign, will be launched by Red MetSIDA, an umbrella organization for AIDS groups in Venezuela. The effort will also feature a high-profile media campaign to bring prevention information to the public and dispel AIDS-related myths. Accion Cuidadana Contra el SIDA, Venezuela's first AIDS organization, has successfully represented 37 HIV-infected individuals who were either irregularly receiving AZT and 3TC or whose physicians were not prescribing triple-drug therapies. The lawsuit, filed against the Venezuelan social security system, argued that the patients' rights were being violated. PMID:11364815

  14. Sialoglycoproteins prepared from the eggs of Carassius auratus prevent bone loss by inhibiting the NF-κB pathway in ovariectomized rats.

    Science.gov (United States)

    Xia, Guanghua; Wang, Jingfeng; Sun, Shuhong; Zhao, Yanlei; Wang, Yiming; Yu, Zhe; Wang, Shanshan; Xue, Changhu

    2016-02-17

    In this study, we investigated the improvement of osteoporosis by sialoglycoproteins isolated from the eggs of Carassius auratus (Ca-SGP) in ovariectomized rats. Ca-SGP was supplemented to ovariectomized Sprague-Dawley rats for 90 days. The results showed that Ca-SGP treatment remarkably prevented the reduction of bone mass, improved cancellous bone structure and biochemical properties. Ca-SGP also significantly decreased the serum contents of TRAP, Cath-K, MMP-9, DPD, CTX-1, Ca, and P. Mechanism investigation revealed that Ca-SGP significantly increased the OPG/RANKL ratio in mRNA expression, protein expression and serum content. Further research suggested that NF-κB signaling pathways were inhibited by suppressing the mRNA and protein expressions of NFATc1 and TRAF6, diminishing the mRNA expression and phosphorylation of NF-κB p65, three key transcription factors in NF-κB pathways. These results suggest that Ca-SGP can improve osteoporosis by inhibiting bone resorption via suppressing the activation of osteoclastogenesis related NF-κB pathways. PMID:26765587

  15. 27 CFR 19.282 - Breaking Government locks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Breaking Government locks. 19.282 Section 19.282 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... measures are taken to prevent illegal removal of spirits and, as soon as practical, shall notify...

  16. Preventing stroke

    Science.gov (United States)

    Stroke - prevention; CVA - prevention; cerebral vascular accident - prevention; TIA - prevention, transient ischemic attack - prevention ... live a longer, healthier life. This is called preventive care. An important way to help prevent stroke ...

  17. Hearing Loss

    Science.gov (United States)

    ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Tools & ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Ask ...

  18. Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway

    Science.gov (United States)

    Ma, Bo; Zhang, Qi; Wu, Di; Wang, Yong-lu; Hu, Ying-ying; Cheng, Yan-ping; Yang, Zhen-dong; Zheng, Ya-ya; Ying, Han-Jie

    2012-01-01

    Aim: To evaluate the protective effects of strontium fructose 1,6-diphosphate (FDP-Sr), a novel strontium salt that combined fructose 1,6-diphosphate (FDP) with strontium, on bone in an ovariectomy-induced model of bone loss. Methods: Eighty female Sprague-Dawley rats were ovariectomized (OVX) or sham-operated. Three months later, the rats were assigned to six groups (10 for each): sham-operated, OVX control, OVX+FDP-Sr (110, 220, or 440 mg/kg), or OVX+strontium ranelate (SR, 180 mg/kg). Drugs were administered orally for 3 months. When the treatment was terminated, the following parameters were assessed: bone mineral density (BMD), the biomechanical properties of the femur and lumbar vertebrae, trabecular histomorphology, serum phosphorus, calcium, bone-specific alkaline phosphatase (B-ALP), tartrate-resistant acid phosphatase 5b (TRACP5b), N-telopeptide of type I collagen (NTx) and a series of markers for oxidative stress. Receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) levels in serum were measured using ELISA and their gene expression levels in the bone were measured using R-T PCR. Results: Treatment with FDP-Sr (220 or 440 mg/kg) or SR (180 mg/kg) significantly increased the BMD and improved the bone microarchitecture and bone strength in OVX rats. The treatments also decreased in the levels of H2O2 and MDA, restored the CAT level in serum and bone marrow, increased the serum B-ALP and decreased NTx and TRACP 5b in OVX rats. Treatment with FDP-Sr decreased the RANKL level, and increased the OPG level in serum in a dose-dependent manner. It also significantly down-regulated the RANKL expression and up-regulated OPG expression in bone marrow. Conclusion: FDP-Sr may be an effectve treatment for postmenopausal osteoporosis that acts, in part, via a decrease in osteoclastogenesis through the OPG\\RANKL\\RANK pathway. PMID:22426695

  19. Spontaneous symmetry breaking in QCD

    International Nuclear Information System (INIS)

    We study dynamical chiral symmetry breaking in QCD by the use of the generalized Hartree-Fock method. The low energy quark mass is calculated to the second order of diagrammatic expansion around shifted perturbative vacuum where quarks are massive. We show that the low energy mass is finite and renormalization group invariant. We find that the finite mass gap emerges as the solutions of gap equation and stationarity condition, thereby breaking the chiral symmetry. We also discuss the possibility that the breaking solution may exist up to all orders. (author)

  20. Randomized, Double-Blinded, Placebo-Controlled, Trial of Risedronate for the Prevention of Bone Mineral Density Loss in Nonmetastatic Prostate Cancer Patients Receiving Radiation Therapy Plus Androgen Deprivation Therapy

    International Nuclear Information System (INIS)

    Purpose: Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this clinical trial was to evaluate the efficacy of risedronate for the prevention of BMD loss in nonmetastatic prostate cancer patients undergoing RT plus 2 to 3 years of ADT. Methods and Materials: A double-blinded, placebo-controlled, randomized trial was conducted for nonmetastatic prostate cancer patients receiving RT plus 2 to 3 years of ADT. All had T scores > −2.5 on dual energy x-ray absorptiometry at baseline. Patients were randomized 1:1 between risedronate and placebo for 2 years. The primary endpoints were the percent changes in the BMD of the lumbar spine at 1 and 2 years from baseline, measured by dual energy x-ray absorptiometry. Analyses of the changes in BMD and bone turnover biomarkers were carried out by comparing mean values of the intrapatient changes between the 2 arms, using standard t tests. Results: One hundred four patients were accrued between 2004 and 2007, with 52 in each arm. Mean age was 66.8 and 67.5 years for the placebo and risedronate, respectively. At 1 and 2 years, mean (±SE) BMD of the lumbar spine decreased by 5.77% ± 4.66% and 13.55% ± 6.33%, respectively, in the placebo, compared with 0.12% ± 1.29% at 1 year (P=.2485) and 0.85% ± 1.56% (P=.0583) at 2 years in the risedronate. The placebo had a significant increase in serum bone turnover biomarkers compared with the risedronate. Conclusions: Weekly oral risedronate prevented BMD loss at 2 years and resulted in significant suppression of bone turnover biomarkers for 24 months for patients receiving RT plus 2 to 3 years of ADT

  1. Randomized, Double-Blinded, Placebo-Controlled, Trial of Risedronate for the Prevention of Bone Mineral Density Loss in Nonmetastatic Prostate Cancer Patients Receiving Radiation Therapy Plus Androgen Deprivation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Richard [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Lukka, Himu [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada); Cheung, Patrick [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada); Corbett, Tom [Department of Radiation Oncology, Juravinski Cancer Center, McMaster University, Hamilton (Canada); Briones-Urbina, Rosario [Department of Medicine, Women' s College Hospital, University of Toronto, Toronto (Canada); Vieth, Reinhold [Departments of Nutritional Sciences and Laboratory Medicine and Pathology, Mount Sinai Hospital, University of Toronto, Toronto (Canada); Ehrlich, Lisa [Department of Radiology, Sunnybrook Health Sciences Center, University of Toronto (Canada); Kiss, Alex [Department of Health Policy, Management, and Evaluation, Sunnybrook Health Sciences Center, University of Toronto, Toronto (Canada); Danjoux, Cyril, E-mail: Cyril.danjoux@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto (Canada)

    2013-04-01

    Purpose: Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this clinical trial was to evaluate the efficacy of risedronate for the prevention of BMD loss in nonmetastatic prostate cancer patients undergoing RT plus 2 to 3 years of ADT. Methods and Materials: A double-blinded, placebo-controlled, randomized trial was conducted for nonmetastatic prostate cancer patients receiving RT plus 2 to 3 years of ADT. All had T scores > −2.5 on dual energy x-ray absorptiometry at baseline. Patients were randomized 1:1 between risedronate and placebo for 2 years. The primary endpoints were the percent changes in the BMD of the lumbar spine at 1 and 2 years from baseline, measured by dual energy x-ray absorptiometry. Analyses of the changes in BMD and bone turnover biomarkers were carried out by comparing mean values of the intrapatient changes between the 2 arms, using standard t tests. Results: One hundred four patients were accrued between 2004 and 2007, with 52 in each arm. Mean age was 66.8 and 67.5 years for the placebo and risedronate, respectively. At 1 and 2 years, mean (±SE) BMD of the lumbar spine decreased by 5.77% ± 4.66% and 13.55% ± 6.33%, respectively, in the placebo, compared with 0.12% ± 1.29% at 1 year (P=.2485) and 0.85% ± 1.56% (P=.0583) at 2 years in the risedronate. The placebo had a significant increase in serum bone turnover biomarkers compared with the risedronate. Conclusions: Weekly oral risedronate prevented BMD loss at 2 years and resulted in significant suppression of bone turnover biomarkers for 24 months for patients receiving RT plus 2 to 3 years of ADT.

  2. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

    Science.gov (United States)

    Conover, Cheryl A.; Johnstone, Edward W.; Turner, Russell T.; Evans, Glenda L.; John Ballard, F. John; Doran, Patrick M.; Khosla, Sundeep

    2002-01-01

    Elevated serum levels of insulin-like growth factor binding protein-2 (IGFBP-2) and a precursor form of IGF-II are associated with marked increases in bone formation and skeletal mass in patients with hepatitis C-associated osteosclerosis. In vitro studies indicate that IGF-II in complex with IGFBP-2 has high affinity for bone matrix and is able to stimulate osteoblast proliferation. The purpose of this study was to determine the ability of the IGF-II/IGFBP-2 complex to increase bone mass in vivo. Osteopenia of the femur was induced by unilateral sciatic neurectomy in rats. At the time of surgery, 14-day osmotic minipumps containing vehicle or 2 microg IGF-II+9 microg IGFBP-2/100g body weight/day were implanted subcutaneously in the neck. Bone mineral density (BMD) measurements were taken the day of surgery and 14 days later using a PIXImus small animal densitometer. Neurectomy of the right hindlimb resulted in a 9% decrease in right femur BMD (PIGFBP-2. On the control limb, there was no loss of BMD over the 14 days and IGF-II/IGFBP-2 treatment resulted in a 9% increase in left femur BMD (PIGFBP-2 complex can prevent loss of BMD associated with disuse osteoporosis and stimulate bone formation in adult rats. Furthermore, they provide proof of concept for a novel anabolic approach to increasing bone mass in humans with osteoporosis.

  3. Topcolor breaking through boundary conditions

    International Nuclear Information System (INIS)

    The nontrivial boundary conditions (BC's) for the topcolor breaking are investigated in the context of the TeV-scale extra dimension scenario. In the gauge symmetry breaking mechanism via the BC's we do not need to incorporate a dynamical mechanism for the topcolor breaking into the model. Moreover, the topcolor breaking can be realized without introducing explicitly a (composite) scalar field. We present a six dimensional model where the top and bottom quarks in the bulk have the topcolor charge while the other quarks in the bulk do not. We also put the electroweak gauge interaction in the six dimensional bulk. The bottom quark condensation is naturally suppressed owing to the powerlike running of the bulk U(1)Y interaction, so that only the top condensation is expected to take place. We explore such a possibility based on the ladder Schwinger-Dyson equation and show the cutoff to make the model viable

  4. Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia

    Directory of Open Access Journals (Sweden)

    Victor Manuel Blanco-Alvarez

    2015-01-01

    Full Text Available Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective and preconditioning effects. Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia. We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO. Male rats were grouped as follows: (1 Zn96h, rats injected with ZnCl2 (one dose every 24 h during four days; (2 Zn96h + CCAO, rats treated with ZnCl2 before CCAO; (3 CCAO, rats with CCAO only; (4 Sham group, rats with mock CCAO; and (5 untreated rats. The cerebral cortex-hippocampus was dissected at different times before and after CCAO. CCL2/CCR2, FGF2, and IGF-1 expression was assessed by RT-PCR and ELISA. Learning in Morris Water Maze was achieved by daily training during 5 days. Long-term memory was evaluated on day 7 after learning. Subacute administration of zinc increased expression of CCL2, CCR2, FGF2, and IGF-1 in the early and late phases of postreperfusion and prevented the CCAO-induced memory loss in the rat. These results might be explained by the induction of neural plasticity because of the expression of CCL2 and growth factors.

  5. A Case Analysis on the Risk Prevention of the Business of Reporting the Loss of Bank Cards%银行卡挂失业务风险防范的案例分析

    Institute of Scientific and Technical Information of China (English)

    王东

    2012-01-01

    目前,由于银行卡挂失业务中责任界定不统一,办理流程不规范,风险防范不到位,因此形成了较大的法律风险、操作风险和道德分析,这也给不法分子造成了可乘之机。本文通过案例分析,提出完善法律规范和业务流程,提高银行风险防控能力的建议。%At present because there is no a uniform definition on the responsibility of the business of reporting the loss of bank cards among financial institutions, the operational process is not regulated and risks are not effectively prevented, legal risks, operational risks and moral hazard have come into being, which provides opportunity for criminals. With analyzing the case, the paper puts forward suggestions such as perfecting the relevant laws and operational processes to improve the capacity of risk prevention and control of banks.

  6. Supersymmetry Breaking in Warped Geometry

    OpenAIRE

    Choi, Kiwoon; Kim, Do Young; Kim, Ian-Woo; Kobayashi, Tatsuo

    2003-01-01

    We examine the soft supersymmetry breaking parameters in supersymmetric theories on a slice of AdS_5 which generate the hierarchical Yukawa couplings by dynamically localizing the bulk matter fields in extra dimension. Such models can be regarded as the AdS dual of the recently studied 4-dimensional models which contain a supersymmetric CFT to generate the hierarchical Yukawa couplings. In such models, if supersymmetry breaking is mediated by the bulk radion superfield and/or some brane chira...

  7. Thefts, break-ins, etc.

    CERN Document Server

    Host States Relations Secretariat

    2005-01-01

    TAKING PRECAUTIONS IS THE BEST MEANS OF PROTECTION On the eve of CERN's annual end-of-year closure, it is in your own interest, that of your colleagues and that of the Organization, that the following recommendations be followed: 1. MONEY, VALUABLES & KEYS: Do not leave money or valuables in your office or your lockers. Keys and their copies should be removed or kept in a safe place. 2. DOORS & WINDOWS: Lock office, workshop, meeting-room doors etc. when you leave. Also close the windows if they are easily accessible from outside. 3. REPORTING INCIDENTS: Each crime solved could prevent another from being perpetrated. Please report any thefts, losses, objects gone missing and other incidents to the CERN Fire Brigade (tel. 74848) and keep them informed of any important developments (objects found, new clues, suspicious people or vehicles, etc.). The Host States Relations Service would like to wish you a Merry Christmas and a Happy New Year! Host States Relations Secretariat Tel. 72848

  8. Traditional preventive treatment options

    DEFF Research Database (Denmark)

    Longbottom, C; Ekstrand, K; Zero, D

    2009-01-01

    prevention of caries in children, e.g. pit and fissure sealants and topically applied fluorides (including patient-applied fluoride toothpastes and professionally applied fluoride varnishes), but limited strong evidence for these techniques for secondary prevention--i.e. where early to established lesions......Preventive treatment options can be divided into primary, secondary and tertiary prevention techniques, which can involve patient- or professionally applied methods. These include: oral hygiene (instruction), pit and fissure sealants ('temporary' or 'permanent'), fluoride applications (patient- or...... conventional operative care, and since controlling the caries process prior to first restoration is the key to breaking the repair cycle and improving care for patients, future research should address the shortcomings in the current level of supporting evidence for the various traditional preventive treatment...

  9. Hidden loss

    DEFF Research Database (Denmark)

    Kieffer-Kristensen, Rikke; Johansen, Karen Lise Gaardsvig

    2013-01-01

    finding indicates that the children experienced numerous losses, many of which were often suppressed or neglected by the children to protect the ill parents. CONCLUSIONS: The findings indicated that the children seemed to make a special effort to hide their feelings of loss and grief in order to protect...

  10. Preventive Maintenance Prioritization by Fuzzy Logic for Seamless Hydro Power Generation

    Science.gov (United States)

    Roy, P. K.; Adhikary, P.; Mazumdar, A.

    2014-06-01

    Preventive maintenance prioritization is one of the most important criteria for the electricity generation planners to minimize the down time and production costs. Break down of equipments increases costs and plant down time results in loss of business. This work focuses on prioritizing the preventive maintenance for seamless hydro power generation considering (24 × 7) client's power demand using fuzzy logic. The main task involves prioritizing the maintenance work considering constraints of varied power demand and hydro turbine plant breakdown. Fuzzy logic is used to optimize the preventive maintenance prioritization under the main constraints. Manual fuzzy arithmetic is used to develop the model and MATLAB Fuzzy Inference System editor used to validate the same. This novel fuzzy logic approach of preventive maintenance prioritizing for hydro power generation is absent in renewable power generation and industrial engineering literatures due to its assessment complexity.

  11. Break-Induced Replication and Genome Stability

    Directory of Open Access Journals (Sweden)

    Anna Malkova

    2012-10-01

    Full Text Available Genetic instabilities, including mutations and chromosomal rearrangements, lead to cancer and other diseases in humans and play an important role in evolution. A frequent cause of genetic instabilities is double-strand DNA breaks (DSBs, which may arise from a wide range of exogeneous and endogeneous cellular factors. Although the repair of DSBs is required, some repair pathways are dangerous because they may destabilize the genome. One such pathway, break-induced replication (BIR, is the mechanism for repairing DSBs that possesses only one repairable end. This situation commonly arises as a result of eroded telomeres or collapsed replication forks. Although BIR plays a positive role in repairing DSBs, it can alternatively be a dangerous source of several types of genetic instabilities, including loss of heterozygosity, telomere maintenance in the absence of telomerase, and non-reciprocal translocations. Also, mutation rates in BIR are about 1000 times higher as compared to normal DNA replication. In addition, micro-homology-mediated BIR (MMBIR, which is a mechanism related to BIR, can generate copy-number variations (CNVs as well as various complex chromosomal rearrangements. Overall, activation of BIR may contribute to genomic destabilization resulting in substantial biological consequences including those affecting human health.

  12. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... optometrist. The exam will include a visual acuity test to determine if the patient does indeed have ... seeing clearly. It may also include a painless test that measures the pressure within the eye but ...

  13. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... a comprehensive examination performed by a qualified eye care professional, such as an ophthalmologist or optometrist. The exam will include a visual acuity test to determine if the patient does indeed have ...

  14. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... vision seemed a little blurry and I decided to get it checked. I thought I just needed new glasses so I never expected what the doctor found. Doctor: I know that Mary has diabetes, so I was looking for diabetic eye ...

  15. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... I could have coped with that and yet it's something that almost happened. Announcer: It almost did happen to Mary Davidson because not long ago, without even knowing it, Mary was going blind. Mary: I'd noticed ...

  16. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... inside the eye. But here's the catch -- the treatments are only helpful if the disease is discovered early and although this may not always be easy, sometimes there are obvious signs of trouble -- Like a change in how colors look or a blurring at the center of ...

  17. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... laser surgery. In this procedure, doctors shine a laser -- a tiny, high energy beam of light into the eye, destroying abnormal blood vessels. Now lasers are also used to seal leaking blood vessels ...

  18. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available Mary: The best things in life? That's easy -- they're my grandchildren. Oh, I know I'm partial but I love just everything about them -- how they ... that to me are the best things in life.

  19. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available Mary: The best things in life? That's easy -- they're my grandchildren. Oh, I know I'm partial but ... depend on me while their mom's at work. The thought of never being able to see them ...

  20. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... a comprehensive examination performed by a qualified eye care professional, such as an ophthalmologist or optometrist. The ... people with diabetes-- that's the recommendation of eye care professionals and that's the way to stop diabetic ...

  1. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... have to seek help. Now the most effective treatment is laser surgery. In this procedure, doctors shine ... inside the eye. But here's the catch -- the treatments are only helpful if the disease is discovered ...

  2. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... I'd noticed that sometimes, my vision seemed a little blurry and I decided to get it ... diabetic eye disease and that's what I discovered, a disease called diabetic retinopathy. It's a good thing ...

  3. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... has diabetes, so I was looking for diabetic eye disease and that's what I discovered, a disease called ... But remember, it's also possible to have diabetic eye disease and experience no symptoms at all. Make no ...

  4. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... exam through dilated pupils at least once a year for people with diabetes-- that's the recommendation of ... those moments that I'm looking forward to years of seeing the things I want to see, ...

  5. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... seek help. Now the most effective treatment is laser surgery. In this procedure, doctors shine a laser -- a tiny, high energy beam of light into the eye, destroying abnormal blood vessels. Now lasers are also used to seal leaking blood vessels ...

  6. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... has diabetes, so I was looking for diabetic eye disease and that's what I discovered, a disease ... tiny, high energy beam of light into the eye, destroying abnormal blood vessels. Now lasers are also ...

  7. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... blind. Mary: I'd noticed that sometimes, my vision seemed a little blurry and I decided to ... the most advanced stages -- can still save their vision but they have to seek help. Now the ...

  8. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... doctor found. Doctor: I know that Mary has diabetes, so I was looking for diabetic eye disease ... at least once a year for people with diabetes-- that's the recommendation of eye care professionals and ...

  9. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... new glasses so I never expected what the doctor found. Doctor: I know that Mary has diabetes, so I ... effective treatment is laser surgery. In this procedure, doctors shine a laser -- a tiny, high energy beam ...

  10. Prevent Vision Loss with Early Diagnosis

    Science.gov (United States)

    ... her eyesight. Ninety percent of the people with diabetic retinopathy -- even those in the most advanced stages -- can still save their vision but they have to seek help. Now the most effective treatment is laser surgery. In this procedure, doctors shine ...

  11. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... her eyesight. Ninety percent of the people with diabetic retinopathy -- even those in the most advanced stages -- can still save their vision but they have to seek help. Now the most effective treatment is laser surgery. In this procedure, doctors shine ...

  12. Prevent Vision Loss with Early Diagnosis

    Medline Plus

    Full Text Available ... and that's what I discovered, a disease called diabetic retinopathy. It's a good thing we caught it when ... her eyesight. Ninety percent of the people with diabetic retinopathy -- even those in the most advanced stages -- can ...

  13. Symmetry breaking in molecular ferroelectrics.

    Science.gov (United States)

    Shi, Ping-Ping; Tang, Yuan-Yuan; Li, Peng-Fei; Liao, Wei-Qiang; Wang, Zhong-Xia; Ye, Qiong; Xiong, Ren-Gen

    2016-07-11

    Ferroelectrics are inseparable from symmetry breaking. Accompanying the paraelectric-to-ferroelectric phase transition, the paraelectric phase adopting one of the 32 crystallographic point groups is broken into subgroups belonging to one of the 10 ferroelectric point groups, i.e. C1, C2, C1h, C2v, C4, C4v, C3, C3v, C6 and C6v. The symmetry breaking is captured by the order parameter known as spontaneous polarization, whose switching under an external electric field results in a typical ferroelectric hysteresis loop. In addition, the responses of spontaneous polarization to other external excitations are related to a number of physical effects such as second-harmonic generation, piezoelectricity, pyroelectricity and dielectric properties. Based on these, this review summarizes recent developments in molecular ferroelectrics since 2011 and focuses on the relationship between symmetry breaking and ferroelectricity, offering ideas for exploring high-performance molecular ferroelectrics. PMID:27051889

  14. Sandwich-type gated mechanical break junctions

    International Nuclear Information System (INIS)

    We introduce a new device architecture for the independent mechanical and electrostatic tuning of nanoscale charge transport. In contrast to previous gated mechanical break junctions with suspended source-drain electrodes, the devices presented here prevent an electromechanical tuning of the electrode gap by the gate. This significant improvement originates from a direct deposition of the source and the drain electrodes on the gate dielectric. The plasma-enhanced native oxide on the aluminum gate electrode enables measurements at gate voltages up to 1.8 V at cryogenic temperatures. Throughout the bending-controlled tuning of the source-drain distance, the electrical continuity of the gate electrode is maintained. A nanoscale island in the Coulomb blockade regime serves as a first experimental test system for the devices, in which the mechanical and electrical control of charge transport is demonstrated.

  15. Give me a better break: Choosing workday break activities to maximize resource recovery.

    Science.gov (United States)

    Hunter, Emily M; Wu, Cindy

    2016-02-01

    Surprisingly little research investigates employee breaks at work, and even less research provides prescriptive suggestions for better workday breaks in terms of when, where, and how break activities are most beneficial. Based on the effort-recovery model and using experience sampling methodology, we examined the characteristics of employee workday breaks with 95 employees across 5 workdays. In addition, we examined resources as a mediator between break characteristics and well-being. Multilevel analysis results indicated that activities that were preferred and earlier in the work shift related to more resource recovery following the break. We also found that resources mediated the influence of preferred break activities and time of break on health symptoms and that resource recovery benefited person-level outcomes of emotional exhaustion, job satisfaction, and organizational citizenship behavior. Finally, break length interacted with the number of breaks per day such that longer breaks and frequent short breaks were associated with more resources than infrequent short breaks. PMID:26375961

  16. Preventing stroke

    Science.gov (United States)

    Stroke - prevention; CVA - prevention; cerebral vascular accident - prevention; TIA - prevention, transient ischemic attack - prevention ... A stroke occurs when the blood supply is cut off to any part of the brain. A stroke is ...

  17. Risk assessment of a dam-break using GIS technology.

    Science.gov (United States)

    Seker, D Z; Kabdasli, S; Rudvan, B

    2003-01-01

    Flood disasters cause massive loss of human lives and immense damage to the infrastructure and economic activities, not only in Turkey but also all over the world. Governments consider several long-term and short-term precautions for flood control. The numerical simulation of dam-break problems could be accomplished with geographic information systems and innovation maps. Spread of the flood wave after a dam break can be predicted using these enabling technologies. This kind of advanced modelling technology is becoming an inevitable tool for the decision-making process. Data produced by GIS are used as initial values for FLDWAV. ArcView GIS has been used to produce a Digital Elevation Model and visualization of dam-break effects and propagation of a possible flood wave. Using GIS techniques and hydrologic modelling software, possible effects and damage of a dam-break flood have been investigated and results were simulated to show significant dam break effects on the region. PMID:15137157

  18. Application of the international guidelines for machinery breakdown prevention at nuclear power plants

    International Nuclear Information System (INIS)

    For more than forty years as a specialized branch of the worldwide insurance industry, the nuclear insurance pools have underwritten property damage protection for nuclear facilities throughout the world. At power plants insured by the pools, an enviable record of operational safety has been attained. Nevertheless, electrical and mechanical equipment does break down occasionally. Although these failures do not necessarily compromise nuclear safety, they can cause significant damage to equipment, leading to a considerable loss of generating revenue and causing sizeable insurance losses. Since insurance companies have a large financial stake in nuclear power plants, their goal is to minimize insurance losses, including the failure of systems and equipment and ensuing consequential damages. To ensure that the insurance risk is properly underwritten, insurance companies analyze loss information, develop loss prevention guidelines and focus loss control activities on those areas where insurance risk is most significant. This paper provides a chronology of the development of the ''International Guidelines for Machinery Breakdown Prevention at Nuclear Power Plants'' and describes the results of insurance inspections conducted using these guidelines. Included is a summary of guideline content and of insurance loss experience between 1962 and 1999. (author)

  19. An Analysis of Break,Break,Break Based on the Stylistic Theory

    Institute of Scientific and Technical Information of China (English)

    李瑶

    2014-01-01

    Break,Break,Break is a poem by Alfred Lord Tennyson, the Poet Laureate during the Queen Victoria's reign. This exquisite little poem is wel known for the poet’s grief-stricken feelings and heart-broken emotions over the premature death of his best friend, Arthur Henry Hal am. Most of the previous studies on this poem focus on the emotional level to consider it as an elegy, expressing sorrow and lamentation for the death of a particular person. However, in order to have a deep understanding in general, this paper analyzes the poem based on the stylistic theory, concerning on the phonological level and the grammatical level. It aims at helping the readers to cultivate a sense of appropriateness, to sharpen the understanding and appreciation of literary works and to achieve adaptation in translation.

  20. Memory loss

    Science.gov (United States)

    A person with memory loss needs a lot of support. It helps to show the person familiar objects, music, or and photos or play familiar music. Write down when the person should take any medicine or do other ...

  1. High-performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases.

    Science.gov (United States)

    De Orsi, Daniela; Pellegrini, Manuela; Pichini, Simona; Mattioli, Donatella; Marchei, Emilia; Gagliardi, Luigi

    2008-11-01

    A simple high-performance liquid chromatography (HPLC) method with ultraviolet diode array (UV-DAD) and electrospray ionisation mass spectrometry (ESI-MS) detection has been developed for the determination of minoxidil, progesterone, estrone, spironolactone, canrenone, hydrocortisone and triamcinolone acetonide in cosmetic products. The presence of these substances in commercial cosmetic samples is prohibited. The compounds were separated by reversed phase chromatography with water (0.1% trifluoroacetic acid) and acetonitrile gradient elution and detected by UV-DAD at 230, 254 and 280 nm and by ESI-MS positive ionisation mode. Benzoic acid was used as internal standard. Linearity was studied with UV-DAD detection from 1.50 to 1,000 microg/ml or mug/g range, depending on the different compounds and type of cosmetic preparation and with ESI-MS in the 50-1,000 ng/ml or ng/g range. Good determination coefficients (r(2)>or=0.99) were found in both UV and ESI-MS. At three concentrations spanning the linear dynamic ranges of both UV-DAD and ESI-MS assay, mean recoveries were always higher than 90% for the different analytes. This method was successfully applied to the analysis of substances under investigations illegally added in cosmetic cream and lotions, sold on internet web sites to prevent hair loss and other hormone-dependent skin diseases, like acne and hirsutism. PMID:18656319

  2. Liquid-Bridge Breaking Limits

    Science.gov (United States)

    Macner, Ashley; Steen, Paul

    2011-11-01

    Wet adhesion by liquid bridges in large arrays shows promise for use in lightweight, controllable on-demand devices. Applications include grab/release of wafer substrates, transport of micron-sized tiles for use in 3D printing and micro-dosing of personalized pharmaceutical drugs. By wetting and spreading, a drop can form a bridge and thereby ``grab'' a nearby solid substrate. By volume decrease or extension, the bridge can break. The breaking limit corresponds to bridge instability which can be predicted, knowing the static mechanical response of the bridge. Mechanical behaviors include force-volume (FV), pressure-volume (pV) and force-length (FL) responses. Instability crucially depends on the mode of failure - failure under constant-force or constant length are typical cases. We study single bridge equilibria for their breaking limits. FV diagrams for the pin-pin equal and pin-pin unequal radii boundary conditions for different bridge heights are measured in the laboratory. The FL response in the case of pin-pin equal radii is also measured. Results are compared to predictions of static theory. Static results are then used to compare to dynamical sequences where volume is driven quasistatically by syringe or an electro-osmotic pump. As the breaking limit is approached, the shape deformation accelerates leading to non-equilibrium shapes not captured by the static analysis.

  3. Strong coupling electroweak symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Barklow, T.L. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Burdman, G. [Univ. of Wisconsin, Madison, WI (United States). Dept. of Physics; Chivukula, R.S. [Boston Univ., MA (United States). Dept. of Physics

    1997-04-01

    The authors review models of electroweak symmetry breaking due to new strong interactions at the TeV energy scale and discuss the prospects for their experimental tests. They emphasize the direct observation of the new interactions through high-energy scattering of vector bosons. They also discuss indirect probes of the new interactions and exotic particles predicted by specific theoretical models.

  4. Sediment transport under breaking waves

    DEFF Research Database (Denmark)

    Christensen, Erik Damgaard; Hjelmager Jensen, Jacob; Mayer, Stefan

    2000-01-01

    generated at the surface where the wave breaks as well as the turbulence generated near the bed due to the wave-motion and the undertow. In general, the levels of turbulent kinetic energy are found to be higher than experiments show. This results in an over prediction of the sediment transport. Nevertheless...

  5. Oil prices: Breaks and trends

    International Nuclear Information System (INIS)

    This paper contributes to the literature of the stationarity of financial time series and the literature on oil and macroeconomics in several ways. First, it uses Kejriwal and Perron (2010) sequential procedure to endogenously determine multiple structural changes in real oil prices without facing the circular testing problem between structural changes and stationary assumptions of previous tests. Second, it performs a diagnostic check to detect the significance and magnitude of the potential breaks. Third, it uses the above information to test for the existence of stochastic trends in real oil prices, and fourth, it speculates about possible explanations for the break dates found in order to encourage further work and discussions. The exercise uses monthly data from January 1861 to August 2011. - Highlights: ► The model endogenously determine multiple structural changes in real oil prices. ► The methods used does not face the circular testing problem. ► It also detect the significance and magnitude of the breaks detected. ► It tests for the existence of stochastic trends. ► It explains the reasons for the break dates found

  6. Instantons and chiral symmetry breaking

    International Nuclear Information System (INIS)

    A detailed investigation of chiral symmetry breaking due to instanton dynamics is carried out, within the framework of the dilute gas approximation, for quarks in both the fundamental and adjoint representations of SU(2). The momentum dependence of the dynamical mass is found to be very similar in each representation. (orig.)

  7. Code breaking in the pacific

    CERN Document Server

    Donovan, Peter

    2014-01-01

    Covers the historical context and the evolution of the technically complex Allied Signals Intelligence (Sigint) activity against Japan from 1920 to 1945 Describes, explains and analyzes the code breaking techniques developed during the war in the Pacific Exposes the blunders (in code construction and use) made by the Japanese Navy that led to significant US Naval victories

  8. How do accretion discs break?

    Science.gov (United States)

    Dogan, Suzan

    2016-07-01

    Accretion discs are common in binary systems, and they are often found to be misaligned with respect to the binary orbit. The gravitational torque from a companion induces nodal precession in misaligned disc orbits. In this study, we first calculate whether this precession is strong enough to overcome the internal disc torques communicating angular momentum. We compare the disc precession torque with the disc viscous torque to determine whether the disc should warp or break. For typical parameters precession wins: the disc breaks into distinct planes that precess effectively independently. To check our analytical findings, we perform 3D hydrodynamical numerical simulations using the PHANTOM smoothed particle hydrodynamics code, and confirm that disc breaking is widespread and enhances accretion on to the central object. For some inclinations, the disc goes through strong Kozai cycles. Disc breaking promotes markedly enhanced and variable accretion and potentially produces high-energy particles or radiation through shocks. This would have significant implications for all binary systems: e.g. accretion outbursts in X-ray binaries and fuelling supermassive black hole (SMBH) binaries. The behaviour we have discussed in this work is relevant to a variety of astrophysical systems, for example X-ray binaries, where the disc plane may be tilted by radiation warping, SMBH binaries, where accretion of misaligned gas can create effectively random inclinations and protostellar binaries, where a disc may be misaligned by a variety of effects such as binary capture/exchange, accretion after binary formation.

  9. Small Break Air Ingress Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chang Oh; Eung Soo Kim

    2011-09-01

    The small break air-ingress experiment, described in this report, is designed to investigate air-ingress phenomena postulated to occur in pipes in a very high temperature gas-cooled reactor (VHTRs). During this experiment, air-ingress rates were measured for various flow and break conditions through small holes drilled into a pipe of the experimental apparatus. The holes were drilled at right angles to the pipe wall such that a direction vector drawn from the pipe centerline to the center of each hole was at right angles with respect to the pipe centerline. Thus the orientation of each hole was obtained by measuring the included angle between the direction vector of each hole with respect to a reference line anchored on the pipe centerline and pointing in the direction of the gravitational force. Using this reference system, the influence of several important parameters on the air ingress flow rate were measured including break orientation, break size, and flow velocity . The approach used to study the influence of these parameters on air ingress is based on measuring the changes in oxygen concentrations at various locations in the helium flow circulation system as a function of time using oxygen sensors (or detectors) to estimate the air-ingress rates through the holes. The test-section is constructed of a stainless steel pipe which had small holes drilled at the desired locations.

  10. Inflationary implications of supersymmetry breaking

    NARCIS (Netherlands)

    Borghese, Andrea; Roest, Diederik; Zavala, Ivonne

    2013-01-01

    We discuss a general bound on the possibility to realise inflation in any minimal supergravity with F-terms. The derivation crucially depends on the sGoldstini, the scalar field directions that are singled out by spontaneous supersymmetry breaking. The resulting bound involves both slow-roll paramet

  11. Sensitivity Analyses in Small Break LOCA with HPI-Failure: Effect of Break-Size in Secondary-Side Depressurization

    Science.gov (United States)

    Kinoshita, Ikuo; Torige, Toshihide; Yamada, Minoru

    2014-06-01

    In the case of total failure of the high pressure injection (HPI) system following small break loss of coolant accident (SBLOCA) in pressurized water reactor (PWR), the break size is so small that the primary system does not depressurize to the accumulator (ACC) injection pressure before the core is uncovered extensively. Therefore, steam generator (SG) secondary-side depressurization is necessary as an accident management in order to grant accumulator system actuation and core reflood. A thermal-hydraulic analysis using RELAP5/MOD3 was made on SBLOCA with HPI-failure for Oi Units 3/4 operated by Kansai Electoric Power Co., which are conventional 4 loop PWR plants. The effectiveness of SG secondary-side depressurization procedure was investigated for the real plant design and operational characteristics. The sensitivity analyses using RELAP5/MOD3.2 showed that the accident management was effective for a wide range of break sizes, various orientations and positions. The critical break can be 3 inch cold-leg bottom break.

  12. Propagation Mechanism Analysis Before the Break Point Inside Tunnels

    OpenAIRE

    Guan, Ke; Zhong, Zhangdui; Bo, Ai; Briso Rodriguez, Cesar

    2011-01-01

    There is no unanimous consensus yet on the propagation mechanism before the break point inside tunnels. Some deem that the propagation mechanism follows the free space model, others argue that it should be described by the multimode waveguide model. Firstly, this paper analyzes the propagation loss in two mechanisms. Then, by conjunctively using the propagation theory and the three-dimensional solid geometry, a generic analytical model for the boundary between the free space mechanism and the...

  13. Age-Related Loss of Muscle Mass and Strength

    Directory of Open Access Journals (Sweden)

    Geoffrey Goldspink

    2012-01-01

    Full Text Available Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis. Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem cells that “kick start” local muscle repair and induces hypertrophy.

  14. A model of intrinsic symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Ge, Li [Research Center for Quantum Manipulation, Department of Physics, Fudan University, Shanghai 200433 (China); Li, Sheng [Department of Physics, Zhejiang Normal University, Zhejiang 310004 (China); George, Thomas F., E-mail: tfgeorge@umsl.edu [Office of the Chancellor and Center for Nanoscience, Department of Chemistry and Biochemistry, University of Missouri-St. Louis, St. Louis, MO 63121 (United States); Department of Physics and Astronomy, University of Missouri-St. Louis, St. Louis, MO 63121 (United States); Sun, Xin, E-mail: xin_sun@fudan.edu.cn [Research Center for Quantum Manipulation, Department of Physics, Fudan University, Shanghai 200433 (China)

    2013-11-01

    Different from the symmetry breaking associated with a phase transition, which occurs when the controlling parameter is manipulated across a critical point, the symmetry breaking presented in this Letter does not need parameter manipulation. Instead, the system itself suddenly undergoes symmetry breaking at a certain time during its evolution, which is intrinsic symmetry breaking. Through a polymer model, it is revealed that the origin of the intrinsic symmetry breaking is nonlinearity, which produces instability at the instance when the evolution crosses an inflexion point, where this instability breaks the original symmetry.

  15. 唑来膦酸对髋关节置换后假体柄周围骨丢失的预防效果%Preventive effect of zoledronic acid on bone loss around the prosthesis stem after hip replacement

    Institute of Scientific and Technical Information of China (English)

    刘国青; 苑振峰; 刘鹏; 庞同涛; 张先巍

    2015-01-01

    to prevent fractures surrounding the prosthesis. OBJECTIVE:To observe the preventive effect of zoledronic acid on bone loss surrounding the prosthesis stem after hip replacement. METHODS:A total of 80 patients after total hip replacement in the People’s Hospital of Shenxian from February 2011 to September 2014 were enrol ed in this study. They were divided into two groups (n=40). At 4 days after replacement, patients in the observation group received treatment with zoledronic acid, but those in the control group did not give zoledronic acid. The rest medication was identical between the two groups. Bone mineral density in the hip was measured before replacement and at 1 year after replacement in both groups. Serum calcium and phosphorus levels and alkaline phosphatase activities were observed before replacement, 3 days and 1 year after medication in the two groups. Adverse reaction during medication was recorded in the observation group. RESULTS AND CONCLUSION:The average bone mineral density was significantly decreased in both groups at 1 year after replacement, and significant differences were found as compared with before replacement (P replacement (P0.05). Alkaline phosphatase activities were low in the observation group at 1 year after medication, and significant difference was detected as compared with the control group and that before replacement (P0.05). Within two or three days after medication, nine patients suffered from varying degrees of muscle aches and fever in the observation group, and above symptoms were lessened after taking acetaminophen. These results verify that after total hip replacement, zoledronic acid injection can effectively prevent bone loss around the prosthesis in early stage after replacement, but fever symptoms may occur within a week after replacement. Thus, it is recommended that zoledronic acid injection can be given at 1 week after replacement. If fever and other symptoms appear, acetaminophen can be given.

  16. Breaking GSM with rainbow Tables

    CERN Document Server

    Meyer, Steven

    2011-01-01

    Since 1998 the GSM security has been academically broken but no real attack has ever been done until in 2008 when two engineers of Pico Computing (FPGA manufacture) revealed that they could break the GSM encryption in 30 seconds with 200'000$ hardware and precomputed rainbow tables. Since then the hardware was either available for rich people only or was confiscated by government agencies. So Chris Paget and Karsten Nohl decided to react and do the same thing but in a distributed open source form (on torrent). This way everybody could "enjoy" breaking GSM security and operators will be forced to upgrade the GSM protocol that is being used by more than 4 billion users and that is more than 20 years old.

  17. Renormalizable theories with symmetry breaking

    CERN Document Server

    Becchi, Carlo M

    2016-01-01

    The description of symmetry breaking proposed by K. Symanzik within the framework of renormalizable theories is generalized from the geometrical point of view. For an arbitrary compact Lie group, a soft breaking of arbitrary covariance, and an arbitrary field multiplet, the expected integrated Ward identities are shown to hold to all orders of renormalized perturbation theory provided the Lagrangian is suitably chosen. The corresponding local Ward identity which provides the Lagrangian version of current algebra through the coupling to an external, classical, Yang-Mills field, is then proved to hold up to the classical Adler-Bardeen anomaly whose general form is written down. The BPHZ renormalization scheme is used throughout in such a way that the algebraic structure analyzed in the present context may serve as an introduction to the study of fully quantized gauge theories.

  18. Symmetry breaking in supersymmetric GUTs

    International Nuclear Information System (INIS)

    This paper analyzes the first step of symmetry breaking in N=1 supersymmetric unified theories. The possible patterns of gauge symmetry breaking consistent with supersymmetry are characterized. Some well-known properties of the scalar potential in supersymmetric gauge theories are reviewed. Simple methods to discover which v.e.v.'s of a given multiplet of scalar fields are consistent with the conditions of given equations are introduced. The vanishing of the D2-term and of the F2-term is discussed and a simple lemma derived from the former. The results of these discussions are applied to some possible candidates for a supersymmetric gauge theory based on the gauge groups SU(5), 0(10), and E6

  19. Symmetries, Symmetry Breaking, Gauge Symmetries

    CERN Document Server

    Strocchi, Franco

    2015-01-01

    The concepts of symmetry, symmetry breaking and gauge symmetries are discussed, their operational meaning being displayed by the observables {\\em and} the (physical) states. For infinitely extended systems the states fall into physically disjoint {\\em phases} characterized by their behavior at infinity or boundary conditions, encoded in the ground state, which provide the cause of symmetry breaking without contradicting Curie Principle. Global gauge symmetries, not seen by the observables, are nevertheless displayed by detectable properties of the states (superselected quantum numbers and parastatistics). Local gauge symmetries are not seen also by the physical states; they appear only in non-positive representations of field algebras. Their role at the Lagrangian level is merely to ensure the validity on the physical states of local Gauss laws, obeyed by the currents which generate the corresponding global gauge symmetries; they are responsible for most distinctive physical properties of gauge quantum field ...

  20. Breaking of de Sitter Symmetry

    CERN Document Server

    Bander, Myron

    2010-01-01

    We show that an interacting spin-0 field on a de Sitter space background will break the underlying de Sitter symmetry. This is done first for a (1+1) de Sitter space where a boson-fermion correspondence permits us to solve certain interacting theories by transforming them into free ones of opposite statistics. A massless boson interacting by a sine-Gordon potential is shown to be equivalent to a free massive fermion with the mass depending on the de Sitter time thus breaking the symmetry explicitly. We then show that for larger dimensions and any boson potential, to one loop, an anomaly develops and the currents generating the de Sitter transformations are not conserved.

  1. Complete quantum measurements break entanglement

    International Nuclear Information System (INIS)

    A complete measurement of a quantum observable (POVM) is a measurement of the maximally refined version of the POVM. Complete measurements give information on multiplicities of measurement outcomes and can be used as state preparation procedures. Moreover, any observable can be measured completely. In this Letter, we show that a complete measurement breaks entanglement completely between the system, ancilla and their environment. Finally, consequences for the quantum Zeno effect and complete position measurements are discussed.

  2. 16th Edition Breaks New Ground

    Institute of Scientific and Technical Information of China (English)

    Zhao Fei

    2010-01-01

    @@ Breaking new ground,Intertextile Shanghai Apparel Fabrics,successfully closed its doors on October 22nd,2010at the Shanghai New International Exhibition Centre,attracting a record breaking,more than 57,000 buyers.

  3. Recursos fisioterapêuticos na prevenção da perda da densidade mineral óssea com lesão medular Physiotherapy resources on bone mineral density loss prevention in patients with spinal cord injuries

    Directory of Open Access Journals (Sweden)

    Daniele Rodrigues

    2004-09-01

    Full Text Available Este trabalho é uma revisão bibliográfica sobre os tratamentos fisioterápicos destinados a prevenção, estabilização ou lentificação da perda da densidade mineral óssea em pacientes portadores de lesão medular. Foram encontrados poucos trabalhos que se destinaram aos tratamentos fisioterápicos para desmineralização óssea. Em relação aos tipos de tratamentos encontrados foram: estimulação elétrica funcional, estimulação elétrica funcional com bicicleta ergométrica, ortostatismo e deambulação. Estes tratamentos são bastante questionáveis não tendo um consenso na metodologia, apresentando muitas controvérsias em relação à eficácia dos tratamentos, que serão discutidos no decorrer deste trabalho.This work is bibliographic review about the physiotherapy treatments for the attenuation, prevention and stabilization or slowing down of the bone mineral density loss in spinal cord injured patients. There are few studies focusing the efficiency the physiotherapy treatment for bone demineralization. The kinds of treatments found were: functional electrical stimulation, functional electrical stimulation with an bycicle ergometry, orthostatic and deambulation. These treatments are much questionable, and with no consensus on the methodology, with the lot of controversies in relation to the efficacy of the treatments, which are going to be discussed in the development of this study.

  4. Eficácia da ciclosporina 0,05% na prevenção da perda endotelial no transplante de córnea Efficacy of cyclosporine 0.05% for preventing endothelial loss in corneal transplant

    Directory of Open Access Journals (Sweden)

    Fernando Moro

    2007-10-01

    Full Text Available OBJETIVO: Avaliar a ação da ciclosporina 0,05% tópica na prevenção da perda endotelial no transplante de córnea. MÉTODOS: Estudo retrospectivo de 18 olhos submetidos a transplante penetrante por ceratocone realizados no serviço pelo mesmo cirurgião. Pacientes com microscopia especular com a 1200 células/mm² constituiram o outro grupo (grupo B. O critério de inclusão foi a presença da microscopia especular no período pós-operatório de 6 meses, 1 ano e 2 anos. Os critérios de exclusão foram retransplantes precoces, olhos contralaterais de casos bilaterais, episódios prévios de rejeição ao enxerto, doenças oculares associadas como glaucoma. A análise estatística foi realizada pelos testes de Friedman com significância estatística. Foi realizada uma avaliação da variação percentual de perda endotelial em relação à microscopia especular base, comparada aos períodos de 6 meses x 1 ano x 2 anos. RESULTADOS: No grupo A (pacientes que não utilizaram a ciclosporina 0,05% nos respectivos períodos de 6 meses, 1 ano e 2 anos, observou-se um decréscimo da variação percentual de perda endotelial estatisticamente significante (p = 0,001 . No grupo B (pacientes que utilizaram a ciclosporina 0,05% nos respectivos períodos de 6 meses, 1 ano e 2 anos, observou-se um decréscimo da variação percentual de perda endotelial estatisticamente não significante (p = 0,513 . CONCLUSÃO: Os resultados mostram uma desaceleração da variação percentual de perda endotelial nos transplantes penetrantes de córnea dos pacientes que utilizaram ciclosporina, quando comparados aos pacientes não tratados topicamente com tal medicação, sugerindo eficácia na manutenção das células endoteliais e sobrevida do transplante de córnea.PURPOSE: To assess the efficacy of topical cyclosporine .05% for preventing endothelial loss in cornea transplant. METHODS: Retrospective study of 18 eyes submitted to penetrating transplant due to

  5. Spontaneous Breaking of the Quantum Superposition

    OpenAIRE

    Pankovic, Vladan; Predojevic, Milan

    2007-01-01

    In this work spontaneous (non-dynamical) breaking (effective hiding) of the unitary quantum mechanical dynamical symmetry (superposition) is considered. It represents an especial but very interesting case of the general formalism of the spontaneous symmetry breaking (effective hiding). Conceptual analogies with spontaneous breaking of the gauge symmetry in Weinberg-Sallam's electro-weak interaction are pointed out. Also, consequences of the spontaneous superposition breaking in the measuremen...

  6. The relative influence of habitat loss and fragmentation: do tropical mammals meet the temperate paradigm?

    Science.gov (United States)

    Thornton, Daniel H; Branch, Lyn C; Sunquist, Melvin E

    2011-09-01

    The relative influence of habitat loss vs. habitat fragmentation per se (the breaking apart of habitat) on species distribution and abundance is a topic of debate. Although some theoretical studies predict a strong negative effect of fragmentation, consensus from empirical studies is that habitat fragmentation has weak effects compared with habitat loss and that these effects are as likely to be positive as negative. However, few empirical investigations of this issue have been conducted on tropical or wide-ranging species that may be strongly influenced by changes in patch size and edge that occur with increasing fragmentation. We tested the relative influence of habitat loss and fragmentation by examining occupancy of forest patches by 20 mid- and large-sized Neotropical mammal species in a fragmented landscape of northern Guatemala. We related patch occupancy of mammals to measures of habitat loss and fragmentation and compared the influence of these two factors while controlling for patch-level variables. Species responded strongly to both fragmentation and loss, and response to fragmentation generally was negative. Our findings support previous assumptions that conservation of large mammals in the tropics will require conservation strategies that go beyond prevention of habitat loss to also consider forest cohesion or other aspects of landscape configuration. PMID:21939064

  7. Electroweak symmetry breaking at photon colliders

    International Nuclear Information System (INIS)

    The electroweak-symmetry-breaking sector of the standard model can be weakly-coupled or can be strongly-coupled, which is characterized by some kinds of strong interaction among the Goldstone bosons of the electroweak-symmetry-breaking sector. In this paper, we summarize an investigation of probing the strong electroweak-symmetry-breaking effects at photon colliders. ((orig.))

  8. Investigations of radiation-induced strand breaks of poly(U) in aqueous solutions

    International Nuclear Information System (INIS)

    DNA strand breaks induced by γ irradiation were studied in polyuridylic acid (Poly(U)), a single-strand model substance with a single base. Poly(U) in diluted, aqueous solution was irradiated in a Co-γ source, and the 100 eV yields of strand breaks (Cr values) were determined on the basis of the loss of molecular weight. The molecular weight was determined by small-angle laser light scattering. (orig./PW)

  9. Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication

    OpenAIRE

    Soumini Vasan; Angela Deem; Sreejith Ramakrishnan; Juan Lucas Argueso; Anna Malkova

    2014-01-01

    Break-induced replication (BIR) is a mechanism to repair double-strand breaks (DSBs) that possess only a single end that can find homology in the genome. This situation can result from the collapse of replication forks or telomere erosion. BIR frequently produces various genetic instabilities including mutations, loss of heterozygosity, deletions, duplications, and template switching that can result in copy-number variations (CNVs). An important type of genomic rearrangement specifically link...

  10. Small break LOCA analysis for Maanshan nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Jer-Cherng Kang; Shou-Chuan Chiang; Lang-Chen Wang [Taiwan Power Company, Taipei (China)

    1994-12-31

    Since 1990, Taiwan Power Company has conducted a LWR LOCA technology transfer program on RELAP5YA computer code from Yankee Atomic Electric Company (YAEC). One objective of this program is to acquire the RELAP5YA computer code from YAEC for Taipower in-house licensing analysis. The RELAP5YA is a computer program developed at YAEC for analysing the dynamic behaviour of thermal-hydraulic systems, and it can cover most of the postulated accidents and transients in light water reactor systems. In this paper, Taipower`s engineers have performed a small break loss of coolant accidents analysis for Maanshan nuclear power plant. Thais action is used to perform the licensing actions for increasing the operation margin on the steam generator tube plugging. The result is shown that the steam generator tube can be plugged slightly without a reduction in safety margins. This analysis covers a spectrum of break size for a small break LOCA. For a complete spectrum of the transient and accident analysis, the large break LOCA and the non-LOCA analysis were performed by the fuel vendor for the reload safety evaluation.

  11. Cooling amelioration after a no isolable break of the primary coolant circuit

    International Nuclear Information System (INIS)

    After a non isolable break of the primary coolant circuit, the residual power should be evacuated for a long time permitting core unloading or break clogging. The reliability studies made by EDF has shown that, during this period, the probability of total loss of safety injection systems and residual power evacuation systems was great. The obligation of warrantying this function during a long time has conducted to define H4 and U3 procedures with appeal at movable systems dimensioned to evacuate the residual power and cooling the core under boiling conditions during 15 days after a 1.5 inch break

  12. Thermalhydraulic analysis of Candu 6 100% reactor outlet header break using RELAP5 code

    Energy Technology Data Exchange (ETDEWEB)

    Dupleac, D.; Prisecaru, I.; Ghitescu, P. [Power Plant Engineering Faculty, Politehnica University, Bucharest (Romania); Negut, G. [Institute for Nuclear Research, Pitesti (Romania)

    2007-07-01

    One of the postulated large break losses of coolant accident (LBLOCA) in a Candu reactor is the Reactor Outlet Header (ROH) break. After such an event, the normal coolant flow in the channels downstream the break is disrupted and late stagnation occurs after the pump head is degraded and before emergency core cooling (ECC) injection takes place. Given that the fuel decay and stored energy decreased significantly by that time, the heatup of the fuel sheath is much lower than in the case of 35% Reactor Inlet Header (RIH) break. However, the coolant pressure is much lower than the corresponding one at the 35% RIH break.The combination of a high fuel clad temperature and coolant low-pressure lead to more fuel failure events. Thus, the 100% ROH break has the highest potential for radioactivity release. The paper presents the thermal hydraulic analyses of a 100% reactor outlet header break. The study is done with RELAP5/SCDAP mod 3.4 and the results were compared with those of CATHENA. RELAP5 predicts a slightly faster inventory loss, an extended flow stagnation period and a higher clad temperature.

  13. The behavior of ANGRA 2 nuclear power plant core for a small break LOCA simulated with RELAP5 code

    Science.gov (United States)

    Sabundjian, Gaianê; Andrade, Delvonei A.; Belchior, Antonio, Jr.; da Silva Rocha, Marcelo; Conti, Thadeu N.; Torres, Walmir M.; Macedo, Luiz A.; Umbehaun, Pedro E.; Mesquita, Roberto N.; Masotti, Paulo H. F.; de Souza Lima, Ana Cecília

    2013-05-01

    This work discusses the behavior of Angra 2 nuclear power plant core, for a postulate Loss of Coolant Accident (LOCA) in the primary circuit for Small Break Loss Of Coolant Accident (SBLOCA). A pipe break of the hot leg Emergency Core Cooling System (ECCS) was simulated with RELAP 5 code. The considered rupture area is 380 cm2, which represents 100% of the ECCS pipe flow area. Results showed that the cooling is enough to guarantee the integrity of the reactor core.

  14. 雷洛昔芬对放疗去势大鼠骨丢失的保护作用%Protective effect of raloxifene in preventing bone loss in rats following radiotherapy induced gonadectomy

    Institute of Scientific and Technical Information of China (English)

    陈静; 朱芳; 李贵玲

    2011-01-01

    目的:观察雷洛昔芬(选择性雌激素受体调节剂)对放疗去势大鼠的骨代谢生化指标、骨密度及骨形态学的影响,探讨其对放疗所致卵巢早衰引起骨丢失的保护作用.方法:选用3月龄雌性Wistar大鼠40只,随机分为4组:假放疗组、放疗组、放疗+雷洛昔芬组、放疗+己烯雌酚组,每组10只,16周后,腹主动脉取血,检测血清雌二醇、卵泡刺激素、骨钙素及碱性磷酸酶的水平;处死大鼠,取大鼠右侧股骨,测定各组骨密度;同时取左侧股骨制作骨切片行HE染色,观察骨形态学变化.结果:放疗组及放疗+雷洛昔芬组的雌二醇水平明显低于假放疗组及放疗+己烯雌酚组(P<0.05);而两组的卵泡刺激素水平明显高于假放疗组及放疗+己烯雌酚组(P<0.05);放疗组骨钙素和碱性磷酸酶明显高于其他3组,而另3组无明显差异(P>0.05);放疗组大鼠骨密度显著低于其他3组,其骨小梁稀疏,部分断裂,而另3组骨小梁致密,无明显断裂.结论:大鼠卵巢放疗可致去势,放疗去势后大鼠有骨质丢失发生,而选择性雌激素受体调节剂雷洛昔芬对放疗去势后大鼠的骨丢失有保护作用.%OBJECTIVE To investigate the protective effect of the selective estrogen receptor modulators (SERMs) raloxifene in preventing hone loss secondary to radiotherapy induced premature ovarian failure(POF). This was studied by observing the effects of Raloxifene on biochemical markers of bone metabolism, bone morphology and bone mineral density of rats following radiotherapy induced gonadectomy. METHODS 40 female Wistar rats aged 3 months were randomly divided into 4 groups (10 rats in each group): Group A(sham radiotherapy), Group B(radiotherapy),Group C (radiotherapy and raloxifene) ,Group D(radiotherapy and diethylstilbestrol). All rats were killed 16 weeks later. Then serum estradiol (E2)、 follicle stimulating hormone(FSH),bone gla protein(BGP) and alkaline phosphatase

  15. Breaking stress of neutron star crust

    CERN Document Server

    Chugunov, A I

    2010-01-01

    The breaking stress (the maximum of the stress-strain curve) of neutron star crust is important for neutron star physics including pulsar glitches, emission of gravitational waves from static mountains, and flares from star quakes. We perform many molecular dynamic simulations of the breaking stress at different coupling parameters (inverse temperatures) and strain rates. We describe our results with the Zhurkov model of strength. We apply this model to estimate the breaking stress for timescales ~1 s - 1 year, which are most important for applications, but much longer than can be directly simulated. At these timescales the breaking stress depends strongly on the temperature. For coupling parameter <200, matter breaks at very small stress, if it is applied for a few years. This viscoelastic creep can limit the lifetime of mountains on neutron stars. We also suggest an alternative model of timescale-independent breaking stress, which can be used to estimate an upper limit on the breaking stress.

  16. History of electroweak symmetry breaking

    CERN Document Server

    Kibble, T W B

    2015-01-01

    In this talk, I recall the history of the development of the unified electroweak theory, incorporating the symmetry-breaking Higgs mechanism, as I saw it from my standpoint as a member of Abdus Salam's group at Imperial College. I start by describing the state of physics in the years after the Second World War, explain how the goal of a unified gauge theory of weak and electromagnetic interactions emerged, the obstacles encountered, in particular the Goldstone theorem, and how they were overcome, followed by a brief account of more recent history, culminating in the historic discovery of the Higgs boson in 2012.

  17. Leaders break ground for INFINITY

    Science.gov (United States)

    2008-01-01

    Community leaders from Mississippi and Louisiana break ground for the new INFINITY at NASA Stennis Space Center facility during a Nov. 20 ceremony. Groundbreaking participants included (l to r): Gottfried Construction representative John Smith, Mississippi Highway Commissioner Wayne Brown, INFINITY board member and Apollo 13 astronaut Fred Haise, Stennis Director Gene Goldman, Studio South representative David Hardy, Leo Seal Jr. family representative Virginia Wagner, Hancock Bank President George Schloegel, Mississippi Rep. J.P. Compretta, Mississippi Band of Choctaw Indians representative Charlie Benn and Louisiana Sen. A.G. Crowe.

  18. History of electroweak symmetry breaking

    Science.gov (United States)

    Kibble, T. W. B.

    2015-07-01

    In this talk, I recall the history of the development of the unified electroweak theory, incorporating the symmetry-breaking Higgs mechanism, as I saw it from my standpoint as a member of Abdus Salam's group at Imperial College. I start by describing the state of physics in the years after the Second World War, explain how the goal of a unified gauge theory of weak and electromagnetic interactions emerged, the obstacles encountered, in particular the Goldstone theorem, and how they were overcome, followed by a brief account of more recent history, culminating in the historic discovery of the Higgs boson in 2012.

  19. Supersymmetry breaking in string theory

    International Nuclear Information System (INIS)

    I briefly review the problems with previous investigations of supersymmetry breaking in string theory --- at tree-level, at one-loop, and non-perturbatively. A variant of the original non-perturbative scenario is proposed, in which gaugino condensation takes place in two different strongly-interacting hidden-sector gauge groups. In the new scenario it is possible to generate a large hierarchy of mass scale and to simultaneously stabilize the dilaton at a large expectation value (weak coupling). However, it is still uncertain whether supersymmetry is broken in such a vacuum. 26 refs

  20. Spontaneous Breaking of Flavor Symmetry

    CERN Document Server

    Törnqvist, N A

    1996-01-01

    It is shown that part of the quark masses of the standard model can be generated spontaneously within the strong interactions of QCD. After the breaking of U(Nf) x U(Nf) symmetry by the vacuum, also the resulting flavor symmetric, degenerate meson mass spectrum is shown to be unstable with respect to quantum loops, for rather general models. For a C-degenerate meson spectrum the stable mass spectrum obeys the Okubo-Zweig-Iizuka rule and the approximateequal spacing rule.

  1. Breaking Carbon Lock-in

    DEFF Research Database (Denmark)

    Driscoll, Patrick Arthur

    2014-01-01

    This central focus of this paper is to highlight the ways in which path dependencies and increasing returns (network effects) serve to reinforce carbon lock-in in large-scale road transportation infrastructure projects. Breaking carbon lock-in requires drastic changes in the way we plan future...... transportation infrastructure projects, and documentary evidence presented here from the metropolitan regions of Copenhagen, Denmark and Portland, USA suggest that there may be a discontinuity in the system of automobility (Urry, 2004) thereby increasing the likelihood that such drastic measures may in fact be...

  2. Progress in Electroweak Symmetry Breaking

    CERN Document Server

    Dawson, S

    2015-01-01

    In this talk, I discuss theoretical advances in understanding the properties of the Higgs boson and the implications for models of electroweak symmetry breaking. I begin by reviewing some of the recent progress in Standard Model calculations for Higgs boson production and decay rates, followed by a lightning tour of the use of effective field theories in the search for new physics in the Higgs sector. I end with a discussion of the complementarity of precision Higgs coupling measurements and direct searches for heavy particles for the discovery of Beyond the Standard Model physics in the electroweak sector.

  3. FRAUD PREVENTION SOLUTIONS

    OpenAIRE

    АЛИБЕКОВА Ю.К.

    2015-01-01

    Currently, business ethics and integrity of top managers and employees are often under a big question, so we cannot rely on them. Non-compliant behavior of top management and employees related to fraud and corrupt practices lead to huge financial losses, loss of reputation and litigations. Incidents of internal fraud and embezzlement are happening in every business imaginable. Fraud prevention solutions we recommend are the fundamental for corporate financial compliance. All stakeholders must...

  4. An intermediate break BWR LOCA test (RUN 991) at ROSA-III

    International Nuclear Information System (INIS)

    Double failures on the emergency-core-cooling systems (ECCSs) can be resulted in a case of loss-of-coolant accident (LOCA) of a boiling water reactor (BWR) by assuming an ECCS line break and the single failure criterion on another ECCS. In the Rig-of-Safety Assessment (ROSA)-III program, two BWR LOCA simulation tests with intermediate break areas were performed to experimentally study influences of the ECCS double failures on core cooling phenomena. As there was no break unit in the ROSA-III ECCS lines, two break locations were selected above and below the ECCS line elevation. Namely, one is a main steam line (MSL) break test of RUN 992 which was previously reported. Another one is a single-ended jet pump drive line (JPDL) break test of RUN 991. And this break location effect on the system responses was briefly studied in a report of JAERI 1307. This report presents precise experiment results of RUN 991 with respect to the core cooling phenomena related to transient system mass and also presents additional findings on the influences of ECCS double failures in some intermediate break LOCA tests including above two tests. (author)

  5. Loss Modification Incentives for Insurers Under Expected Utility and Loss Aversion

    OpenAIRE

    Soetevent, Adriaan; Zhou, L.

    2014-01-01

    Forthcoming in 'De Economist'. Given the possibility to modify the probability of a loss, will a profit-maximizing insurer engage in loss prevention or is it in his interest to increase the loss probability? This paper investigates this question. First, we calculate the expected profit maximizing loss probability within an expected utility framework. We then use Köszegi and Rabin's (2006, 2007) loss aversion model to answer the same question for the case where consumers have reference-depende...

  6. Boundary breaking for interdisciplinary learning

    Directory of Open Access Journals (Sweden)

    Adi Kidron

    2015-10-01

    Full Text Available The purpose of this work is to contribute to the body of knowledge on processesby which students develop interdisciplinary understanding of contents, as well as to suggest technology-enhanced means for supporting them in these processes in the context of higher education. In doing so, we suggest a rethinking of three traditional practices that tend to characterise typical higher education instruction: (1 compartmentalisation of disciplines; (2 traditional pedagogy; and (3 traditional hierarchies based on levels of expertise. Our high-level conjecture was that meaningful dialogue with peers and experts supports both the deepening of ideas in one knowledge domain and the formation of connections between ideas from several domains, both of which are required for the development of interdisciplinary understanding. We developed the Boundary Breaking for Interdisciplinary Learning (BBIL model, which harnesses technology to break boundaries between disciplines, learners and organisational levels of hierarchy. Findings indicate that 36 undergraduate students who participated in an interdisciplinary online course that implemented the BBIL model have significantly improved their interdisciplinary understanding of the course contents. This study illustrates how innovative use of available, free and low-cost technology can produce a ‘positive disruption’ in higher education instruction.

  7. Introduction to Electroweak Symmetry Breaking

    Energy Technology Data Exchange (ETDEWEB)

    Dawson,S.

    2008-10-02

    The Standard Model (SM) is the backbone of elementary particle physics-not only does it provide a consistent framework for studying the interactions of quark and leptons, but it also gives predictions which have been extensively tested experimentally. In these notes, I review the electroweak sector of the Standard Model, discuss the calculation of electroweak radiative corrections to observables, and summarize the status of SM Higgs boson searches. Despite the impressive experimental successes, however, the electroweak theory is not completely satisfactory and the mechanism of electroweak symmetry breaking is untested. I will discuss the logic behind the oft-repeated statement: 'There must be new physics at the TeV scale'. These lectures reflect my strongly held belief that upcoming results from the LHC will fundamentally change our understanding of electroweak symmetry breaking. In these lectures, I review the status of the electroweak sector of the Standard Model, with an emphasis on the importance of radiative corrections and searches for the Standard Model Higgs boson. A discussion of the special role of the TeV energy scale in electroweak physics is included.

  8. Chiral symmetry breaking and monopoles

    CERN Document Server

    Di Giacomo, Adriano; Pucci, Fabrizio

    2015-01-01

    To understand the relation between the chiral symmetry breaking and monopoles, the chiral condensate which is the order parameter of the chiral symmetry breaking is calculated in the $\\overline{\\mbox{MS}}$ scheme at 2 [GeV]. First, we add one pair of monopoles, varying the monopole charges $m_{c}$ from zero to four, to SU(3) quenched configurations by a monopole creation operator. The low-lying eigenvalues of the Overlap Dirac operator are computed from the gauge links of the normal configurations and the configurations with additional monopoles. Next, we compare the distributions of the nearest-neighbor spacing of the low-lying eigenvalues with the prediction of the random matrix theory. The low-lying eigenvalues not depending on the scale parameter $\\Sigma$ are compared to the prediction of the random matrix theory. The results show the consistency with the random matrix theory. Thus, the additional monopoles do not affect the low-lying eigenvalues. Moreover, we discover that the additional monopoles increa...

  9. Observation of parity-time symmetry breaking transitions in a dissipative Floquet system of ultracold atoms

    CERN Document Server

    Li, Jiaming; Liu, Ji; de Melo, Leonardo; Joglekar, Yogesh N; Luo, Le

    2016-01-01

    Open physical systems with balanced loss and gain exhibit a transition, absent in their solitary counterparts, which engenders modes that exponentially decay or grow with time and thus spontaneously breaks the parity-time PT symmetry. This PT-symmetry breaking is induced by modulating the strength or the temporal profile of the loss and gain, but also occurs in a pure dissipative system without gain. It has been observed that, in classical systems with mechanical, electrical, and electromagnetic setups with static loss and gain, the PT-symmetry breaking transition leads to extraordinary behavior and functionalities. However, its observation in a quantum system is yet to be realized. Here we report on the first quantum simulation of PT-symmetry breaking transitions using ultracold Li-6 atoms. We simulate static and Floquet dissipative Hamiltonians by generating state-dependent atom loss in a noninteracting Fermi gas, and observe the PT-symmetry breaking transitions by tracking the atom number for each state. W...

  10. Scaling effects concerning the analysis of small break experiments

    International Nuclear Information System (INIS)

    Some scaling effects related to the experimental facilities as well as to the analytical models used for the design and safety analysis of nuclear power plants are discussed or the basis of phenomena expected to occur during small-break loss - of - coolant accidents. The results of isolated small-break experiments should not be directly extrapolated to the safety analysis of commercial reactors, due to the scaling distortions inherent to the test facilities. With respect to the analytical models used to simulate thermohydraulic processes in experimental facilities, their eventual dependence relative to the system dimension should be examined in order to assess their applicability to the safety analysis of commercial power plants. (Author)

  11. Do DNA Double-Strand Breaks Drive Aging?

    Science.gov (United States)

    White, Ryan R; Vijg, Jan

    2016-09-01

    DNA double-strand breaks (DSBs) are rare, but highly toxic, lesions requiring orchestrated and conserved machinery to prevent adverse consequences, such as cell death and cancer-causing genome structural mutations. DSBs trigger the DNA damage response (DDR) that directs a cell to repair the break, undergo apoptosis, or become senescent. There is increasing evidence that the various endpoints of DSB processing by different cells and tissues are part of the aging phenotype, with each stage of the DDR associated with specific aging pathologies. In this Perspective, we discuss the possibility that DSBs are major drivers of intrinsic aging, highlighting the dynamics of spontaneous DSBs in relation to aging, the distinct age-related pathologies induced by DSBs, and the segmental progeroid phenotypes in humans and mice with genetic defects in DSB repair. A model is presented as to how DSBs could drive some of the basic mechanisms underlying age-related functional decline and death. PMID:27588601

  12. [Prevention of osteoporosis].

    Science.gov (United States)

    Dambacher, M A; Kissling, R; Neff, M

    1998-11-01

    The European Parliament presented June 10th in Brussels the 'Osteoporosis Report in EU--Means for Prevention'. It was emphasized that in the EU more than 3500 million Ecu have to be spent for hospitalization and that more than 500,000 hospitals beds are being used by osteoporotic patients. According to some calculations this number will double within the next 50 years. The EU has set up eight steps to be considered, e.g. have densitometric measurements available for persons with high risk and have these measurement paid by the insurances to further finance and support research for the very important areas of prevention and treatment. One distinguishes between primary, secondary and tertiary prevention of osteoporosis. Primary prevention aims at reaching at adolescent age a peak bone mass as high as possible. Secondary prevention aims at reducing bone loss peri- and postmenopausal. The tertiary prevention with manifest osteoporosis aims at preventing fractures. Emphasis of the primary prevention is, besides a sufficient calcium intake, to omit risk factors; with secondary prevention the use of medical treatments such as estrogens/gestagens, bisphosphonates, and recently also SERMs is applied. The tertiary prevention tries mostly to reduce the femur fractures. In addition to drugs such as vitamin D/calcium, vitamin D metabolites and bisphosphonates it is very important to create 'a fall-proof home'. Also very useful are hip protectors. PMID:9865147

  13. Rape prevention

    Science.gov (United States)

    Date rape - prevention; Sexual assault - prevention ... Centers for Disease Control and Prevention (CDC). Sexual assault and STDs. In: Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep . 2010;17(59)(RR-12):90- ...

  14. Economics of Garlic Production in Baran District of Rajasthan; Break Even Analysis

    OpenAIRE

    Lokesh Kumar Meena; Chandra Sen; Arun jhajharia; N. K. Raghuwanshi

    2013-01-01

    The study focuses on economic analysis of garlic production in the Baran District of Rajasthan. The study is carried out to determine break even analysis and constraints of garlic production in the study area. Break even analysis is carried out to arrive at that minimum level at which optimum conditions of cost and returns is equated that is no profit no loss point. In this study selected small, medium and large farmers will not be at loss even if their actual yield of garlic is decline by 56...

  15. Electroweak Symmetry Breaking by QCD

    CERN Document Server

    Kubo, Jisuke; Lindner, Manfred

    2014-01-01

    We propose a new mechanism to generate the electroweak scale within the framework of QCD, which is extended to include conformally invariant scalar degrees of freedom belonging to a larger irreducible representation of $SU(3)_c$. The electroweak symmetry breaking is triggered dynamically via the Higgs portal by the condensation of the colored scalar field around $1$ TeV. The mass of the colored boson is restricted to be $350$ GeV $\\lesssim m_S\\lesssim 3$ TeV, with the upper bound obtained from renormalization group evolution. This implies that the colored boson can be produced at LHC. If the colored boson is electrically charged, the branching fraction of the Higgs decaying into two photons can slightly increase, and moreover, it can be produced at future linear colliders.

  16. Symmetry Breaking in Finite Volume

    Institute of Scientific and Technical Information of China (English)

    LIU Chuan

    2000-01-01

    Spontaneous symmetry breaking is a cooperative phenomenon for systems with infinitely many degrees of freedom and it plays an essential role in quantum field theories. Lattice O(N) model is studied within the Hamiltonian approach using an adiabatic approximation. It is shown that the low-lying spectrum of the system in the broken phase can be understood by using the adiabatic, or Born-Oppenheimer approximation, which turns out to become an expansion in the inverse power of volume. In the infinite volume limit, the symmetry is broken while in the finite volume the slow rotation of the zero-momentum mode restores the symmetry and gives rise to the rotator spectrum, which has been observed in realistic Monte Carlo simulations.

  17. Z'-mediated supersymmetry breaking.

    Science.gov (United States)

    Langacker, Paul; Paz, Gil; Wang, Lian-Tao; Yavin, Itay

    2008-02-01

    We consider a class of models in which supersymmetry breaking is communicated dominantly via a U1' gauge interaction, which also helps solve the mu problem. Such models can emerge naturally in top-down constructions and are a version of split supersymmetry. The spectrum contains heavy sfermions, Higgsinos, exotics, and Z' approximately 10-100 TeV, light gauginos approximately 100-1000 GeV, a light Higgs boson approximately 140 GeV, and a light singlino. A specific set of U1' charges and exotics is analyzed, and we present five benchmark models. The implications for the gluino lifetime, cold dark matter, and the gravitino and neutrino masses are discussed. PMID:18352261

  18. Dynamical centrosymmetry breaking in graphene

    CERN Document Server

    Carvalho, David N; Biancalana, Fabio

    2016-01-01

    We discover an unusual phenomenon that occurs when a graphene monolayer is illuminated by a short and intense pulse at normal incidence. Due to the pulse-induced oscillations of the Dirac cones, a dynamical breaking of the layer's centrosymmetry takes place, leading to the generation of second harmonic waves. We prove that this result can only be found by using the full Dirac equation and show that the widely used semiconductor Bloch equations fail to reproduce this and some other important physics of graphene. Our results open new windows in the understanding of nonlinear light-matter interactions in a wide variety of new 2D materials with a gapped or ungapped Dirac-like dispersion.

  19. Breaking the cycle of abuse.

    Science.gov (United States)

    Egeland, B; Jacobvitz, D; Sroufe, L A

    1988-08-01

    The aim of this study was to identify variables that distinguish mothers who broke the cycle of abuse from mothers who were abused as children and who also abused their own children. Based on maternal interviews and questionnaires completed over a 64-month period, measures of mothers' past and current relationship experiences, stressful life events, and personality characteristics were obtained. Abused mothers who were able to break the abusive cycle were significantly more likely to have received emotional support from a nonabusive adult during childhood, participated in therapy during any period of their lives, and to have had a nonabusive and more stable, emotionally supportive, and satisfying relationship with a mate. Abused mothers who reenacted their maltreatment with their own children experienced significantly more life stress and were more anxious, dependent, immature, and depressed. PMID:3168615

  20. Mutual information and spontaneous symmetry breaking

    OpenAIRE

    Hamma, A.; Giampaolo, S. M.; Illuminati, F.

    2015-01-01

    We show that the metastable, symmetry-breaking ground states of quantum many-body Hamiltonians have vanishing quantum mutual information between macroscopically separated regions, and are thus the most classical ones among all possible quantum ground states. This statement is obvious only when the symmetry-breaking ground states are simple product states, e.g. at the factorization point. On the other hand, symmetry-breaking states are in general entangled along the entire ordered phase, and t...

  1. Gravity with background fields and diffeomorphism breaking

    CERN Document Server

    Bluhm, Robert

    2016-01-01

    Effective gravitational field theories with background fields break local Lorentz symmetry and diffeomorphism invariance. Examples include Chern-Simons gravity, massive gravity, and the Standard-Model Extension (SME). The physical properties and behavior of these theories depend greatly on whether the spacetime symmetry breaking is explicit or spontaneous. With explicit breaking, the background fields are fixed and nondynamical, and the resulting theories are fundamentally different from Einstein's General Relativity (GR). However, when the symmetry breaking is spontaneous, the background fields are dynamical in origin, and many of the usual features of Einstein's GR still apply.

  2. Loss Modification Incentives for Insurers Under Expected Utility and Loss Aversion

    NARCIS (Netherlands)

    Soetevent, Adriaan R.; Zhou, Liting

    2016-01-01

    We investigate whether a profit-maximizing insurer with the opportunity to modify the loss probability will engage in loss prevention or instead spend effort to increase the loss probability. First we study this question within a traditional expected utility framework; then we apply Koszegi and Rabi

  3. The Tax Break's Double Bind.

    Science.gov (United States)

    Milner, Jeffrey L.; And Others

    1990-01-01

    Stimulating economic activity by offering tax abatements can deprive schools of tax revenues for years while enrollment is increasing. Taking action forestalled a substantial loss of revenue for the Twinsburg City Schools in Ohio. Offers advice to boards facing a similar circumstance and suggests ways school boards can be involved in enterprise…

  4. Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir.

    Science.gov (United States)

    Schneider, Jessica Y; Rothmann, Sabine; Schröder, Frank; Langen, Jennifer; Lücke, Thomas; Mariotti, François; Huneau, Jean François; Frölich, Jürgen C; Tsikas, Dimitrios

    2015-09-01

    prostacyclin and thromboxane synthesis (in PAOD). In the PAOD study, UNOxR did not change in the Arginine group (480 ± 51 vs 486 ± 50), but fell in the Placebo group (422 ± 67 vs 332 ± 42, P = 0.025). In the CAD study, UNOxR did not change significantly in the Arginine group (518 ± 77 at start vs 422 ± 40 after 3 months vs 399 ± 66 after 6 months), but fell in the Placebo group (524 ± 69 vs 302 ± 36 vs 285 ± 31; P = 0.025 for 0 vs 3 months). Infusion of Arg tended to decrease the UNOxR in the children (317 ± 41 vs 208 ± 16, P = 0.06). We propose that oral long-term Arg supplementation prevents loss of NO bioactivity by saving nitrite. The optimum Arg dose needs to be elaborated and is likely to be less than 10 g per day in adults. Orally and intravenously administered arginine was well tolerated by the elderly patients and young children, respectively. PMID:26123989

  5. Cytokines and bone loss in a 5-year longitudinal study--hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: the Danish Osteoporosis Prevention Study

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Bonnevie-Nielsen, V; Ebbesen, E N; Gram, J; Beck-Nielsen, H

    2000-01-01

    The proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-6 may play a central role in the acceleration of postmenopausal bone loss, but observational studies have led to contradictory results. Estrogen-dependent changes in the production of IL-1 receptor antagonist (IL-1ra) and the.......16; p = 0.17). In conclusion, serum IL-1ra and sIL-6R are influenced by HRT and are associated with the rate of bone loss in perimenopausal women....

  6. Parity-Time Symmetry Breaking in Coupled Nanobeam Cavities

    CERN Document Server

    Zhang, Senlin; Zhang, Yuguang; He, Sailing

    2015-01-01

    The parity-time symmetry (PT symmetry) breaking phenomenon is investigated in a coupled nanobeam cavity system. An exceptional point is observed during the tuning of the relation of the gain/loss and coupling strength of the closely placed nanobeam pairs. The PT symmetry concept can be applied to realize unidirectional light propagation and single mode operation lasers, which may allow for a new way to harness the optical signal in photonic integrated circuits. Otherwise, operating at this particular exceptional point, sensitivity of tiny perturbation detection can be enhanced greatly compared with conventional sensors.

  7. Breaking the ice: Theorizing the mechanisms of Arctic thaw

    Science.gov (United States)

    Rennermalm, Asa K.; Mioduszewski, John; Moustafa, Samiah

    2012-10-01

    Breaking the Ice: Theorizing the Arctic Thaw;New Brunswick, New Jersey, 12-14 April 2012 Some of the most striking contemporary environmental changes are the warming of the Arctic region and increased mass loss from the Greenland ice sheet. For example, areas of summer melt atop Greenland's massive ice sheet continue to expand, sending large volumes of ice and meltwater into surrounding seas and oceans. This may have profound implications for regional hydrology and marine biogeochemical cycles, as well as global sea level rise. While these trends are readily observable, urgent questions regarding how the Greenland ice sheet will respond to future climate change remain unanswered.

  8. Application of the statistical safety evaluation method to the small break LOCA with high pressure injection failure. Sensitivity analyses to determine the break conditions

    International Nuclear Information System (INIS)

    By applying a statistical safety evaluation method, the uncertainties of best estimate results can be estimated quantitatively, and as a consequence, excessive conservatism can be reasonably removed to obtain evaluation results with enhanced reliability. Application of a statistical evaluation method is being made to analyses of the “low pressure injection by intentional depressurization of the steam generator secondary side” which is an accident management approach in a SBLOCA (small break loss-of-coolant accident) with HPI (high pressure injection) failure. At the time of a SBLOCA, the break conditions such as the break size are important parameters since they influence PCT (peak cladding temperature). In this research, sensitivity analyses about the break size, direction and position were carried out for a system plant under a condition which the start timing of the steam generator secondary side intentional depressurization is severer than an actual abnormal operating condition. From the result of the sensitivity analyses, differences in the phenomena progression which change depending on the break conditions were evaluated, and a 3 inch facing-down break of the cold-leg was determined as the base case of a statistical safety evaluation. (author)

  9. Ultralow-loss CMOS copper plasmonic waveguides

    DEFF Research Database (Denmark)

    Fedyanin, Dmitry Yu.; Yakubovsky, Dmitry I.; Kirtaev, Roman V.; Volkov, Valentyn S.

    2016-01-01

    microelectronics manufacturing technologies. This prevents plasmonic components from integration with both silicon photonics and silicon microelectronics. Here, we demonstrate ultralow-loss copper plasmonic waveguides fabricated in a simple complementary metal-oxide semiconductor (CMOS) compatible process, which...

  10. On breaks of the Indian monsoon

    Indian Academy of Sciences (India)

    Sulochana Gadgil; P V Joseph

    2003-12-01

    For over a century, the term break has been used for spells in which the rainfall over the Indian monsoon zone is interrupted. The phenomenon of `break monsoon' is of great interest because long intense breaks are often associated with poor monsoon seasons. Such breaks have distinct circulation characteristics (heat trough type circulation) and have a large impact on rainfed agriculture.Although interruption of the monsoon rainfall is considered to be the most important feature of the break monsoon, traditionally breaks have been identified on the basis of the surface pressure and wind patterns over the Indian region. We have defined breaks (and active spells) on the basis of rainfall over the monsoon zone. The rainfall criteria are chosen so as to ensure a large overlap with the traditional breaks documented by Ramamurthy (1969) and De et al (1998). We have identified these rainbreaks for 1901-89. We have also identified active spells on the basis of rainfall over the Indian monsoon zone. We have shown that the all-India summer monsoon rainfall is significantly negatively correlated with the number of rainbreak days (correlation coefficient −0.56) and significantly positively correlated with the number of active days (correlation coefficient 0.47).Thus the interannual variation of the all-India summer monsoon rainfall is shown to be related to the number of days of rainbreaks and active spells identified here. There have been several studies of breaks (and also active spells in several cases) identified on the basis of different criteria over regions differing in spatial scales (e.g., Webster et al 1998; Krishnan et al 2000; Goswami and Mohan 2000; and Annamalai and Slingo 2001). We find that there is considerable overlap between the rainbreaks we have identified and breaks based on the traditional definition. There is some overlap with the breaks identified by Krishnan et al (2000) but little overlap with breaks identified by Webster et al (1998). Further

  11. Simulation of the primary circuit breaks in the training simulator

    International Nuclear Information System (INIS)

    The pressurized water reactors (PWR) have been designed to operate in the way that normally there is only one-phase liquid in the primary circuit. In the primary break accidents, however, the primary pressure decreases as a consequence of the coolant discharge and a two-phase condition may occur. Large computer codes like RELAP5 and TRAC, which consume lots of computer time, are used for the simulation of reactor systems in small break loss of coolant accidents (SBLOCA). The full-scope training simulator of the Loviisa pressurized water reactor has been improved by backfitting a two-phase model SMABRE to the simulator. The two-phase model is necessarily needed when the primary circuit breaks are simulated. The basic physical models in the SMABRE are similar to those in the large simulation codes, but making some simplifications the real time simulation on a PDP-11/70 computer is possible. Two nodalization models, one with 26 volumes and the other with 61 volumes, have been applied in the training simulator. The main reason for the use of the more detailed model is the need to take into account the variations of primary loop elevations. (author)

  12. Steamline break analysis for 1000 MWe Kudankulam nuclear power plant

    International Nuclear Information System (INIS)

    Full text: Thermal hydraulic analysis has been carried out for the steamline break outside the containment of VVER-1000 reactor. 1000 MWe VVER is a light water moderated, light water-cooled pressurised water reactor with four primary coolant loops. The double-ended break in the non-isolable steamline was considered, as it will result in higher heat removal by the secondary circuit. This analysis has been carried out using thermal hydraulic code RELAP5/MOD 3.2. As a result of steam generator steamline rupture the steam begins out flowing from the secondary circuit, the secondary pressure decreases. Consequently the coolant temperature, coolant pressures in the primary circuit decrease. Due to negative coolant temperature reactivity, the increase of the reactor power can take place. The end of refuelling cycle is considered in the present analysis since the coolant feedbacks are the most negative and increase of reactor power is maximum. Also loss of power is not considered in the analysis as it results more coolant temperature and great rise in power takes place. The analysis predicts thermal hydraulic conditions following steamline break. Thermal hydraulic conditions like pressure, temperature, and flow at different locations in the PHT as well as in secondary side in the steam generator have been estimated during the transient. The analysis results have been discussed and compared with the acceptance criteriam

  13. Detecting Structural Breaks using Hidden Markov Models

    DEFF Research Database (Denmark)

    Ntantamis, Christos

    Testing for structural breaks and identifying their location is essential for econometric modeling. In this paper, a Hidden Markov Model (HMM) approach is used in order to perform these tasks. Breaks are defined as the data points where the underlying Markov Chain switches from one state to another...

  14. Electroweak Symmetry Breaking and the Higgs Boson

    CERN Document Server

    Pich, Antonio

    2015-01-01

    The first LHC run has confirmed the Standard Model as the correct theory at the electroweak scale, and the existence of a Higgs-like particle associated with the spontaneous breaking of the electroweak gauge symmetry. These lectures overview the present knowledge on the Higgs boson and discuss alternative scenarios of electroweak symmetry breaking which are already being constrained by the experimental data.

  15. Multiscale Simulation of Breaking Wave Impacts

    DEFF Research Database (Denmark)

    Lindberg, Ole

    compare reasonably well. The incompressible and inviscid ALE-WLS model is coupled with the potential flow model of Engsig-Karup et al. [2009], to perform multiscale calculation of breaking wave impacts on a vertical breakwater. The potential flow model provides accurate calculation of the wave...... potential flow model to provide multiscale calculation of forces from breaking wave impacts on structures....

  16. DNA Replication Reaches the Breaking Point

    OpenAIRE

    Petrini, John H.J.

    2009-01-01

    DNA strand breaks that result in stalled or damaged replication forks can be detrimental to the DNA replication process. In this issue, Doksani et al. (2009) examine the impact of a single double-stranded DNA break on replication in the budding yeast, Saccharomyces cerevisiae.

  17. Four Top Production and Electroweak Symmetry Breaking

    OpenAIRE

    Cheung, Kingman

    1995-01-01

    With the recent discovery of a heavy top quark $(m_t \\approx 175 - 200$ GeV), the top quark opens an window to electroweak symmetry breaking. We propose the study of four-top, $t\\bar t t\\bar t$, production at hadronic supercolliders as a probe to electroweak symmetry breaking.

  18. Anatomy of String Breaking in QCD

    OpenAIRE

    Prkacin, Zdravko; Bali, Gunnar S.; Dussel, Thomas; Lippert, Thomas; Neff, Hartmut; Schilling, Klaus

    2005-01-01

    We investigate the string breaking mechanism in n_f=2 QCD. We discuss the lattice techniques used and present results on energy levels and mixing angle of the static BBbar|QbarQ two-state system. The string breaking is visualized, by means of an animation of the action density distribution as a function of the static colour source-antisource separation.

  19. Get Outside, Get Moving to Prevent 'Gamer's Thumb'

    Science.gov (United States)

    ... Outside, Get Moving to Prevent 'Gamer's Thumb' Playing video games hour after hour can trigger repetitive stress injuries, ... anyone who spends a lot of time playing video games. But taking breaks can be just what the ...

  20. Big break for charge symmetry

    CERN Document Server

    Miller, G A

    2003-01-01

    Two new experiments have detected charge-symmetry breaking, the mechanism responsible for protons and neutrons having different masses. Symmetry is a crucial concept in the theories that describe the subatomic world because it has an intimate connection with the laws of conservation. The theory of the strong interaction between quarks - quantum chromodynamics - is approximately invariant under what is called charge symmetry. In other words, if we swap an up quark for a down quark, then the strong interaction will look almost the same. This symmetry is related to the concept of sup i sospin sup , and is not the same as charge conjugation (in which a particle is replaced by its antiparticle). Charge symmetry is broken by the competition between two different effects. The first is the small difference in mass between up and down quarks, which is about 200 times less than the mass of the proton. The second is their different electric charges. The up quark has a charge of +2/3 in units of the proton charge, while ...

  1. Research progress on dam-break floods

    KAUST Repository

    Wu, Jiansong

    2011-08-01

    Because of the catastrophic effects downstream of dam-break failure, more and more researchers around the world have been working on the study of dam-break flows to accurately forecast the downstream inundation mapping. With the rapid development of computer hardware and computing techniques, numerical study on dam-break flows has been a popular research subject. In the paper, the numerical methodologies used to solve the governing partial differential equations of dam-break flows are classified and summarized, and their characteristics and applications are discussed respectively. Furthermore, the fully-developed mathematical models developed in recent decades are reviewed, and also introduced the authors\\' on-going work. Finally, some possible future developments on modeling the dam-break flows and some solutions are presented and discussed. © 2011 IEEE.

  2. Supersymmetry Breaking by Higher Dimension Operators

    CERN Document Server

    Farakos, Fotis; Kehagias, Alex; Porrati, Massimo

    2014-01-01

    We discuss a supersymmetry breaking mechanism for N = 1 theories triggered by higher dimensional op- erators. We consider such operators for real linear and chiral spinor superfields that break superymmetry and reduce to the Volkov-Akulov action. We also consider supersymmetry breaking induced by a higher dimensional operator of a nonminimal scalar (complex linear) multiplet. The latter differs from the stan- dard chiral multiplet in its auxiliary sector, which contains, in addition to the complex scalar auxiliary of a chiral superfield, a complex vector and two spinors auxiliaries. By adding an appropriate higher di- mension operator, the scalar auxiliary may acquire a nonzero vev triggering spontaneous supersymmetry breaking. We find that the spectrum of the theory in the supersymmetry breaking vacuum consists of a free chiral multiplet and a constraint chiral superfield describing the goldstino. Interestingly, the latter turns out to be one of the auxiliary fermions, which becomes dynamical in the supersym...

  3. Chiral symmetry and chiral-symmetry breaking

    International Nuclear Information System (INIS)

    These lectures concern the dynamics of fermions in strong interaction with gauge fields. Systems of fermions coupled by gauge forces have a very rich structure of global symmetries, which are called chiral symmetries. These lectures will focus on the realization of chiral symmetries and the causes and consequences of thier spontaneous breaking. A brief introduction to the basic formalism and concepts of chiral symmetry breaking is given, then some explicit calculations of chiral symmetry breaking in gauge theories are given, treating first parity-invariant and then chiral models. These calculations are meant to be illustrative rather than accurate; they make use of unjustified mathematical approximations which serve to make the physics more clear. Some formal constraints on chiral symmetry breaking are discussed which illuminate and extend the results of our more explicit analysis. Finally, a brief review of the phenomenological theory of chiral symmetry breaking is presented, and some applications of this theory to problems in weak-interaction physics are discussed

  4. Mixing-induced spontaneous supersymmetry breaking

    International Nuclear Information System (INIS)

    It is conjectured that flavor mixing furnishes a universal mechanism for the spontaneous breaking of supersymmetry. The conjecture is proved explicitly for the mixing of two chiral N=1 supermultiplets and arguments for its general validity are given. That is an instance of the O'Raifeartaigh Lagrangian for which there is no tree-level nor perturbative breaking. Nonetheless, the dynamical breaking occurs due to the vacuum condensate, a mixing-induced nonperturbative effect that lifts the zero point energy. -- Highlights: → In this paper we propose a novel mechanism for spontaneous supersymmetry (SUSY) breaking based on flavor mixing. → We prove the conjecture in detail for the free massive Wess-Zumino case and give robust arguments for the general validity. → We present here is a dynamical SUSY breaking that is induced by a nonperturbative quantum effect.

  5. A laboratory study of breaking waves

    Directory of Open Access Journals (Sweden)

    Jaros³aw Têgowski

    2004-09-01

    Full Text Available This paper deals with some aspects of the wave-breaking phenomenon. The objectives were to study wave-breaking criteria, and the probability of whitecap coverage under fully controlled wave conditions. An additional task was to in vestigate the characteristic spectral features of the noise produced by breaking waves and the acoustic energy generated during wave breaking events. A controlled experiment was carried out in the Ocean Basin Laboratory at MARINTEK, Trondheim (Norway. Waves were generated by a computer-controlled multi-flap wave maker, which reproduced a realistic pattern of the sea surface for the prescribed spectra. Using wave staff recordings and photographic techniques, correlations between the breaking parameters and the radiated acoustic emissions were established.

  6. PT-symmetry breaking with divergent potentials: lattice and continuum cases

    CERN Document Server

    Joglekar, Yogesh N; Saxena, Avadh

    2014-01-01

    We investigate the parity- and time-reversal ($\\mathcal{PT}$)-symmetry breaking in lattice models in the presence of long-ranged, non-hermitian, $\\mathcal{PT}$-symmetric potentials that remain finite or become divergent in the continuum limit. By scaling analysis of the fragile $\\mathcal{PT}$ threshold for an open finite lattice, we show that continuum loss-gain potentials $V_\\alpha(x)\\propto i |x|^\\alpha \\mathrm{sign}(x)$ have a positive $\\mathcal{PT}$-breaking threshold for $\\alpha>-2$, and a zero threshold for $\\alpha\\leq -2$. When $\\alpha<0$ localized states with complex (conjugate) energies in the continuum energy-band occur at higher loss-gain strengths. We investigate the signatures of $\\mathcal{PT}$-symmetry breaking in coupled waveguides, and show that the emergence of localized states dramatically shortens the relevant time-scale in the $\\mathcal{PT}$-symmetry broken region.

  7. DNA double strand break induction in yeast

    International Nuclear Information System (INIS)

    The induction of DNA double strand breaks (DSBs) by accelerated heavy ions was systematically measured in diploid yeast cells. Particles were provided by the accelerators at GSI, Darmstadt, and HMI, Berlin. DNA was separated using pulsed field gel electrophoresis and the intensity of the largest bands used to determine the loss of molecular weight. Since the DNA content of each chromosome is exactly known absolute values for DSB induction can be measured without calibration procedures. Ions used range from protons to uranium with LET values between 2 and about 15,000 keV.μm-1. Induction cross sections increase in the lower LET region approaching a plateau around 200 keV.μm-1. With higher LET values the dependence can no longer be described by a common curve with each ion showing a specific behaviour. With very heavy particles the influence of the penumbra becomes obvious: cross sections decrease with LET because of the reduced penumbra extensions. Classical target theory would predict cross sections to follow a simple saturation function which is not substantiated by the data. Track structure analysis as introduced by Butts and Katz in Radiat. Res. 30 855-71 1967 is also not able to predict the experimental results. A semi-empirical fit indicates a linear-quadratic dependence of induction cross sections on LET up to about 1000 keV.μm-1. RBE for DSB induction rises above unity reaching a maximum of about 2.5 around 200 keV.μm-1. This is different from many experiments in mammalian cells and is presumably due to differences in chromatin structure since yeast cells seem to lack a functional H1 histone. (author)

  8. Curbing Teen Dating Violence: Evidence from a School Prevention Program. RB-9194-CDC

    Science.gov (United States)

    Jaycox, Lisa H.; McCaffrey, Daniel F.; Weidmer Ocampo, Beverly; Marshall, Grant N.; Collins, Rebecca L.; Hickman, Laura J.; Quigley, Denise D.

    2006-01-01

    This research brief summarizes a survey about the effectiveness of programs from Break the Cycle, a nonprofit organization dedicated to developing and fielding dating-violence prevention programs. The study evaluated "Ending Violence," a three-class-session prevention program. Developed by a Los Angeles-based nonprofit group called Break the…

  9. Drowning Prevention

    Science.gov (United States)

    ... Listen Español Text Size Email Print Share Drowning Prevention: Information for Parents Page Content Article Body Drowning ... in very cold water for lengthy periods. Drowning Prevention: Know the Warning Signs These signs may signal ...

  10. Genetics of x-ray induced double strand break repair in saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    The possible fates of x-ray-induced double-strand breaks in Saccharomyces cerevisiae were examined. One possible pathway which breaks can follow, the repair pathway, was studied by assaying strains with mutations in the RAD51, RAD54, and RAD57 loci for double-strand break repair. In order of increasing radiation sensitivity one finds: rad57-1(230)> rad51-1(300)> rad54-3(360). At 360, rad54-3 cells cannot repair double-strand breaks, while 230, they can. Strains with the rad57-1 mutation can rejoin broken chromosomes at both temperatures. However, the low survival at 360 shows that the assay is not distinguishing large DNA fragments which allow cell survival from those which cause cell death. A rad51-1 strain could also rejoin broken chromosomes, and was thus capable of incomplete repair. The data can be explained with the hypothesis that rad54-3 cells are blocked in an early step of repair, while rad51-1 and rad57-1 strains are blocked in a later step of repair. The fate of double-strand breaks when they are left unrepaired was investigated with the rad54-3 mutation. If breaks are prevented from entering the RAD54 repair pathway they become uncommitted lesions. These lesions are repaired slower than the original breaks. One possible fate for an uncommitted lesion is conversion into a fixed lesion, which is likely to be an unrepairable or misrepaired double-strand break. The presence of protein synthesis after irradiation increases the probability that a break will enter the repair pathway. Evidence shows that increased probability of repair results from enhanced synthesis of repair proteins shortly after radiation

  11. 医院护理人员流失的相关因素分析与预防对策%Analysis and Preventive Measures of Related Factors of Nursing Staff Loss in Hospital

    Institute of Scientific and Technical Information of China (English)

    徐佳

    2015-01-01

    The loss of nursing staff in hospital is an important factor to influence the normal operation and management of the hospital,the nursing staff loss is caused to the loss of intangible assets and the huge replacement cost,the factors causing the loss of nursing staff include:occupation pressure, psychological pressure,social pressure,compiling factors,so do a good job in human resources management,avoid talent erosion is the important content of hospital management work.We should through the improvement of personnel system standard management,improve remuneration to retain talent,humanized management,reduce stress,strengthen quality education to establish the correct values and other measures to avoid loss of nursing staff.%医院护理人员流失问题是影响医院正常运营和管理的重要因素,护理人员的流失带来的是无形资产的流失和巨大的重置成本。造成护理人员流失的因素包括职业压力、心理压力、社会压力、编制因素,因而做好人力资源管理、避免人才流失是医院管理工作中的重要内容,应通过完善人事制度、规范管理、提高薪酬待遇留住人才、人性化管理减少压力、加强素质教育、树立正确的价值观等措施来避免护理人员的流失。

  12. Vision Loss, Sudden

    Science.gov (United States)

    ... of age-related macular degeneration. Spotlight on Aging: Vision Loss in Older People Most commonly, vision loss ... Some Causes and Features of Sudden Loss of Vision Cause Common Features* Tests Sudden loss of vision ...

  13. Breaking stress of neutron star crust

    International Nuclear Information System (INIS)

    Complete text of publication follows. The breaking stress (the maximum of the stress-strain curve) of neutron star crust is important for neutron star physics including pulsar glitches, emission of gravitational waves from static mountains, and flares from star quakes. We perform many molecular dynamic simulations of the breaking stress at different coupling parameters (inverse temperatures), strain rates and composition of matter. We describe our results with the Zhurkov model of strength. We apply this model to estimate the breaking stress for timescales ∼1 s - 1 year, which are most important for applications, but much longer than can be directly simulated. At these timescales the breaking stress depends strongly on the temperature. For coupling parameter Γ<200 matter breaks at very small stress, if it is applied for a few years. This viscoelastic creep can limit the lifetime of mountains on neutron stars. We also suggest an alternative model of timescale-independent breaking stress, which can be used to estimate an upper limit on the breaking stress. This work was partially supported by the Russian Foundation for Basic Research (grant 11-02-00253-a), by the State Program 'Leading Scientific Schools of Russian Federation' (grant NSh 3769.2010.2), by the President grant for young Russian scientists (MK-5857.2010.2), by United States DOE grant (DE-FG02-87ER40365) and by Shared University Research grants from IBM, Inc. to Indiana University.

  14. Preventing Addiction.

    Science.gov (United States)

    Moore, Susan Fordney

    The purpose of this paper is to provide the beginning counselor with an overview of prevention concepts. Prevention is a relatively new emphasis in community efforts to stem the rising costs of substance abuse and other high-risk behaviors. The paper discusses agent, host, and environmental prevention models and how they relate to causal theories…

  15. Understanding heterogeneity of social preferences for fire prevention management

    DEFF Research Database (Denmark)

    Varela, Elsa; Jacobsen, Jette Bredahl; Soliño, Mario

    2014-01-01

    The forest area burnt annually in the European Mediterranean region has more than doubled since the 1970s. In these forests, the main preventive action consists of forest compartmentalization by fuel break networks, which entail high costs and sometimes significant negative impacts. While many...... studies look at public preferences for fire suppression, this study analyses the heterogeneity of social preferences for fire prevention. The visual characteristics of fire prevention structures are very familiar to respondents, but their management is unfamiliar, which raises specific attention in terms...... for the density of fuel breaks. These results are important for designing fire prevention policies that are efficient and acceptable by the population....

  16. Dirac Neutrino Masses from Generalized Supersymmetry Breaking

    International Nuclear Information System (INIS)

    We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the standard model with a generalized supersymmetry breaking sector. If the superpotential neutrino Yukawa terms are forbidden by the gauge symmetry [such as a U(1)'], sub-eV scale effective Dirac mass terms can arise at tree level from hard supersymmetry breaking Yukawa couplings, or at one loop due to nonanalytic soft supersymmetry breaking trilinear scalar couplings. The radiative neutrino magnetic and electric dipole moments vanish at one-loop order

  17. Spontaneous chiral parity breaking by hydromagnetic buoyancy

    CERN Document Server

    Chatterjee, Piyali; Brandenburg, Axel; Rheinhardt, Matthias

    2010-01-01

    Evidence for a parity-breaking nature of the magnetic buoyancy instability in a stably stratified gas is reported. In the absence of rotation, no helicity is produced, but the non-helical state is found to be unstable to small helical perturbations during the development of the instability. The parity-breaking nature of an instability in magnetohydrodynamics appears to be the first of its kind and is similar to chiral symmetry breaking in biochemistry. Applications to the production of mean fields in galaxy clusters are being discussed.

  18. Spontaneous chiral symmetry breaking by hydromagnetic buoyancy

    Science.gov (United States)

    Chatterjee, Piyali; Mitra, Dhrubaditya; Brandenburg, Axel; Rheinhardt, Matthias

    2011-08-01

    Evidence for the parity-breaking nature of the magnetic buoyancy instability in a stably stratified gas is reported. In the absence of rotation, no helicity is produced, but the nonhelical state is found to be unstable to small helical perturbations during the development of the instability. The parity-breaking nature of this magnetohydrodynamic instability appears to be the first of its kind and has properties similar to those in chiral symmetry breaking in biochemistry. Applications to the production of mean fields in galaxy clusters are discussed.

  19. Formation of radiation-induced DNA breaks: the ratio of double-strand breaks to single-strand breaks

    International Nuclear Information System (INIS)

    Ionizing radiation causes the formation of strand breaks in cellular DNA, as well as other types of lesions in the chromatin of cells. Some of the earliest investigations of the molecular basis of radiation-induced damage and the implications of enzymatic repair were done by Dr. H. S. Kaplan. Because it is difficult to assay for DNA lesions in the large mammalian genome, the authors have developed a method of assaying for DNA double-strand breaks in the supercoiled nucleosome-complexed Simian virus 40 (SV40) genome, irradiated intracellularly. In this communication they present their measurements of the DNA double-strand breaks (DSBs) to single-strand breaks (SSBs) ratio obtained from the intracellularly irradiated SV40 genome. After cobalt gamma ray and X ray irradiations, this ratio is about 1/10. Their methods and results are compared with pertinent data in the literature. If the DSBs/SSBs ratio of 1/10 for cellular chromatin is correct, a substantial number of DNA double-strand breaks are formed in a mammalian cell after moderate doses (1 Gy) of radiation. The implications of different types of DNA double-strand breaks are discussed

  20. Unconventional supersymmetry and its breaking

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, Pedro D., E-mail: alvarez@physics.ox.ac.uk [Centro de Estudios Científicos (CECS), Av. Arturo Prat 514, Valdivia (Chile); Universidad Andrés Bello, Av. República 440, Santiago (Chile); Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford (United Kingdom); Pais, Pablo, E-mail: pais@cecs.cl [Centro de Estudios Científicos (CECS), Av. Arturo Prat 514, Valdivia (Chile); Universidad Andrés Bello, Av. República 440, Santiago (Chile); Zanelli, Jorge, E-mail: z@cecs.cl [Centro de Estudios Científicos (CECS), Av. Arturo Prat 514, Valdivia (Chile); Universidad Andrés Bello, Av. República 440, Santiago (Chile)

    2014-07-30

    We present a gauge theory for a superalgebra that includes an internal gauge (G) and local Lorentz (so(1,D−1)) algebras. These two symmetries are connected by fermionic supercharges. The field content of the system includes a (non-)abelian gauge potential A, a spin-1/2 Dirac spinor ψ, the Lorentz connection ω{sup ab}, and the vielbein e{sub μ}{sup a}. The connection one-form A is in the adjoint representation of G, while ψ is in the fundamental. In contrast to standard supersymmetry and supergravity, the metric is not a fundamental field and is in the center of the superalgebra: it is not only invariant under the internal gauge group, G, and under Lorentz transformations, SO(1,D−1), but is also invariant under supersymmetry. The distinctive features of this theory that mark the difference with standard supersymmetries are: i) the number of fermionic and bosonic states is not necessarily the same; ii) there are no superpartners with equal mass; iii) although this supersymmetry originates in a local gauge theory and gravity is included, there is no gravitino; iv) fermions acquire mass from their coupling to the background or from higher order self-couplings, while bosons remain massless. In odd dimensions, the Chern–Simons (CS) form provides an action that is (quasi-)invariant under the entire superalgebra. In even dimensions, the Yang–Mills (YM) form is the only natural option and the symmetry breaks down to G⊗SO(1,D−1). In four dimensions, the construction follows the Townsend–Mac Dowell–Mansouri approach, starting with an osp(4|2)∼usp(2,2|1) connection. Due to the absence of osp(4|2)-invariant traces in four dimensions, the resulting Lagrangian is only invariant under u(1)⊕so(3,1), which includes a Nambu–Jona-Lasinio (NJL) term. In this case, the Lagrangian depends on a single dimensionful parameter that fixes Newton's constant, the cosmological constant and the NJL coupling.

  1. Successive breaks in biliary stents.

    Science.gov (United States)

    Espinel, Jesús; Pinedo, Eugenia; Ojeda, Vanesa; Guerra, María

    2016-04-01

    A 64 year-old male, was diagnosed with obstructive jaundice due to a well-differentiated pancreatic neuroendocrine tumor with liver metastases. The patient underwent endoscopic placement of covered self-expanding biliary stent (10x60 mm, Hanaro) by ERCP. He was admitted with cholangitis one year later. The following ERCP revealed a fractured stent with loss of the distal end (duodenal) and partial migration of the remaining stent to the common bile duct. The fragmented stent was removed from the common bile duct and a new, similar one was inserted. Four months later the patient was admitted with cholangitis. A new ERCP was done and biliary stent was also fragmented. It was removed and an uncovered stent (Wallflex) was inserted. PMID:27065248

  2. Evaluation of the effects of break nozzle configuration in the Semiscale Mod-1 system

    International Nuclear Information System (INIS)

    The Semiscale Mod-1 Program has utilized two different break nozzle configurations in the test system. An evaluation has been made to determine the effect these break nozzle configurations have on system thermal-hydraulic response during a 200 percent double-ended cold leg break loss-of-coolant accident simulation. The first nozzle was a convergent-divergent nozzle (Henry nozzle) and the second, an elongated constant area throat nozzle. Analysis is confined primarily to system response phenomena observed to be affected by the nozzle configuration and concentrates on the fluid response at the break and the resulting core behavior during subcooled and saturated blowdown. The evaluation shows that considerable difference in system response occurs as a result of the difference in break nozzle configuration. The elongated throat nozzle was scaled from the Loss-of-Fluid Test (LOFT) nozzle geometry and since the LOFT counterpart tests were designed to provide results for the LOFT Program, the elongated throat nozzle was used in the subsequent LOFT counterpart tests

  3. Dirac neutrino masses from generalized supersymmetry breaking

    International Nuclear Information System (INIS)

    We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the Standard Model with a generalized supersymmetry breaking sector. If the usual superpotential Yukawa couplings are forbidden by the additional gauge symmetry (such as a U(1)'), effective Dirac mass terms involving the ''wrong Higgs'' field can arise either at tree level due to hard supersymmetry breaking fermion Yukawa couplings, or at one-loop due to nonanalytic or ''nonholomorphic'' soft supersymmetry breaking trilinear scalar couplings. As both of these operators are naturally suppressed in generic models of supersymmetry breaking, the resulting neutrino masses are naturally in the sub-eV range. The neutrino magnetic and electric dipole moments resulting from the radiative mechanism also vanish at one-loop order. (orig.)

  4. Dirac Neutrino Masses from Generalized Supersymmetry Breaking

    CERN Document Server

    Demir, Durmus A; Langacker, Paul

    2007-01-01

    We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the Standard Model with a generalized supersymmetry breaking sector. If the usual superpotential Yukawa couplings are forbidden by the additional gauge symmetry (such as a U(1)'), effective Dirac mass terms involving the "wrong Higgs" field can arise either at tree level due to hard supersymmetry breaking fermion Yukawa couplings, or at one-loop due to nonanalytic or "nonholomorphic" soft supersymmetry breaking trilinear scalar couplings. As both of these operators are naturally suppressed in generic models of supersymmetry breaking, the resulting neutrino masses are naturally in the sub-eV range. The neutrino magnetic and electric dipole moments resulting from the radiative mechanism also vanish at one-loop order.

  5. Spontaneous chiral symmetry breaking in metamaterials

    Science.gov (United States)

    Liu, Mingkai; Powell, David A.; Shadrivov, Ilya V.; Lapine, Mikhail; Kivshar, Yuri S.

    2014-07-01

    Spontaneous chiral symmetry breaking underpins a variety of areas such as subatomic physics and biochemistry, and leads to an impressive range of fundamental phenomena. Here we show that this prominent effect is now available in artificial electromagnetic systems, enabled by the advent of magnetoelastic metamaterials where a mechanical degree of freedom leads to a rich variety of strong nonlinear effects such as bistability and self-oscillations. We report spontaneous symmetry breaking in torsional chiral magnetoelastic structures where two or more meta-molecules with opposite handedness are electromagnetically coupled, modifying the system stability. Importantly, we show that chiral symmetry breaking can be found in the stationary response of the system, and the effect is successfully demonstrated in a microwave pump-probe experiment. Such symmetry breaking can lead to a giant nonlinear polarization change, energy localization and mode splitting, which provides a new possibility for creating an artificial phase transition in metamaterials, analogous to that in ferrimagnetic domains.

  6. An analysis of MB-2 100% steam line break test T-2013 using RELAP5/MOD2

    International Nuclear Information System (INIS)

    This report presents RELAP5/MOD2 calculations of the 100% steam line break test T-2013 performed on the Westinghouse Model Boiler-2 facility (MB-2). The input deck uses a noding structure typical of what would be used for an integral rig or full plant study using the RELAP5/MOD2 code. Sensitivity calculations were performed for the break junction discharge coefficient and the separator drain line loss coefficient. (author)

  7. Preventive aspects regarding back pain.

    Science.gov (United States)

    Dorner, Thomas E; Crevenna, Richard

    2016-02-01

    Prevention, as the act of keeping from happening, aims to avert things that would occur if no intervention would be taken. From the epidemiology of back pain, consequences of the disease that are worth preventing can be derived. Biological, psychological, and social factors lead to back pain and chronification and ultimately to various adverse outcomes. The most important preventable consequences of back pain include loss of ability to function in daily life, loss of work productivity, sickness absence, and disability pension, excessive and inappropriate healthcare utilisation, impairments in quality of life, and disturbance of sexual life. The most important tools for prevention of back pain lie within rehabilitation after acute pain treatment and include exercise and physical training as well as health education and increasing health literacy. The bio-psycho-social nature of back pain must be taken into account in all preventive measures. PMID:26695480

  8. Anatomic consideration for preventive implantation.

    Science.gov (United States)

    Denissen, H W; Kalk, W; Veldhuis, H A; van Waas, M A

    1993-01-01

    The aim of preventive implant therapy is to prevent or delay loss of alveolar ridge bone mass. For use in an anatomic study of 60 mandibles, resorption of the alveolar ridge was classified into four preventive stages: (1) after extraction of teeth; (2) after initial resorption; (3) when the ridge has atrophied to a knife-edge shape; and (4) when only basal bone remains. Implantation in stage 3 necessitates removal of the knife-edge ridge to create space for cylindrical implants. Therefore, implantation in stage 2 is advocated to prevent the development of stage 3. The aim of implantation in stage 4 is to prevent total loss of function of the atrophic mandible. PMID:8359876

  9. Relativistic theory of string breaking in QCD

    CERN Document Server

    Simonov, Yu A

    2011-01-01

    The QCD string breaking due to quark pair creation in the vacuum confining field, possibly accompanied by vector, scalar or Nambu-Goldstone bosons, is studied nonperturbatively. The scalar light pair creation vertex occurs due to chiral symmetry breaking and has a confining form, which is computed explicitly together with subleading vector contributions. Dependence on light quark mass and flavor is specifically studied. The dominant scalar term is in good agreement with the $^3P_0$ model and experimental data.

  10. AIR LOAD BREAK SWITCH DESIGN PARAMETERS

    OpenAIRE

    Støa-Aanensen, Nina Sasaki

    2015-01-01

    Current interruption is vital in the power system, as this makes it possible to control the use of different loads, change the grid configuration, and minimize damage when faults occur. This thesis presents a study of the different switch design and test circuit parameters involved in medium voltage air load break switching and how they affect the thermal interrupting capability. Mediumvoltage load break switches are common in the distribution grid, and are a cheaper option ...

  11. Grand unification with large supersymmetry breaking

    International Nuclear Information System (INIS)

    General criteria are given for the magnitudes of mass splittings between supersymmetric partners compatible with the desired hierarchy of mass scales in GUTs. These splittings arise naturally when masses are generated radiatively from a Higgs sector breaking supersymmetry through the O'Raifeartaigh mechanism (Nucl. Phys; B96:331 (1975)). Explicit GUTs are constructed in which the supersymmetry breaking scale may easily be as large as the Planck mass. (author)

  12. Dirac Neutrino Masses from Generalized Supersymmetry Breaking

    OpenAIRE

    Demir, Durmus A.; Everett, Lisa L.; Langacker, Paul

    2007-01-01

    We demonstrate that Dirac neutrino masses in the experimentally preferred range are generated within supersymmetric gauge extensions of the Standard Model with a generalized supersymmetry breaking sector. If the usual superpotential Yukawa couplings are forbidden by the additional gauge symmetry (such as a U(1)'), effective Dirac mass terms involving the "wrong Higgs" field can arise either at tree level due to hard supersymmetry breaking fermion Yukawa couplings, or at one-loop due to nonana...

  13. A random fuse model for breaking processes

    OpenAIRE

    de Arcangelis, L.; Redner, S.; Herrmann, H. J.

    1985-01-01

    We introduce and study a simple idealized model to describe breaking processes by analysing the current-carrying properties of a random network consisting of insulators and fuses. By increasing the value of the external voltage applied across the network, a sequence of fuses will « burn out » and change irreversible into insultating bonds. This process terminates when a conducting path no longer exists in the network. We monitor several basic quantities during this breaking process, such as t...

  14. Yet another symmetry breaking to be discovered

    CERN Document Server

    Yoshimura, M

    2016-01-01

    The discovery of spontaneous symmetry breaking in particle physics was the greatest contribution in Nambu's achievements. There is another class of symmetries that exist in the low energy nature, yet is doomed to be broken at high energy, due to a lack of protection of the gauge symmetry. I shall review our approach to search for this class of symmetry breaking, the lepton number violation linked to generation of the matter-antimatter asymmetry in our universe.

  15. Dark matter from dynamical SUSY breaking

    OpenAIRE

    Fan, JiJi; Thaler, Jesse; Wang, Lian-Tao

    2010-01-01

    We consider explicit models of dynamical supersymmetry breaking where dark matter is a 10 – 100 TeV strongly-interacting composite state carrying no standard model quantum numbers. These constructions are simple variants of well-known supersymmetry breaking mechanisms, augmented to allow for a large “flavor” symmetry. Dark matter is the lightest composite modulus charged under this symmetry and is a viable cold dark matter candidate with a thermal relic abundance. This is an at...

  16. Holographic realization of gauge mediated supersymmetry breaking

    CERN Document Server

    Skenderis, Kostas

    2012-01-01

    The general gauge mediation scenario provides a framework in which properties of a visible sector with soft supersymmetry breaking are computed from current correlation functions in the supersymmetry breaking hidden sector. In this paper we will use holography to model strongly coupled hidden sectors by weakly curved geometries and describe how the current correlators relevant for general gauge mediation are computed by holographic methods. We illustrate the general setup by a toy example which captures most of the relevant features.

  17. Chimera Death: Symmetry Breaking in Dynamical Networks

    OpenAIRE

    Zakharova, Anna; Kapeller, Marie; Schöll, Eckehard

    2014-01-01

    For a network of generic oscillators with nonlocal topology and symmetry-breaking coupling we establish novel partially coherent inhomogeneous spatial patterns, which combine the features of chimera states (coexisting incongruous coherent and incoherent domains) and oscillation death (oscillation suppression), which we call chimera death. We show that due to the interplay of nonlocality and breaking of rotational symmetry by the coupling two distinct scenarios from oscillatory behavior to a s...

  18. Yet another symmetry breaking to be discovered

    Science.gov (United States)

    Yoshimura, M.

    2016-07-01

    The discovery of spontaneous symmetry breaking in particle physics was the greatest contribution in Nambu's achievements. There is another class of symmetries that exist in low-energy nature, yet is doomed to be broken at high energy, due to a lack of protection of the gauge symmetry. I shall review our approach to searching for this class of symmetry breaking, the lepton number violation linked to the generation of the matter-antimatter asymmetry in our universe.

  19. Can AGN feedback break the self-similarity of galaxies, groups, and clusters?

    CERN Document Server

    Gaspari, M; Temi, P; Ettori, S

    2014-01-01

    It is commonly thought that AGN feedback can break the self-similar scaling relations of galaxies, groups, and clusters. Using high-resolution 3D hydrodynamic simulations, we isolate the impact of AGN feedback on the $L_{\\rm x}-T_{\\rm x} $ relation, testing the two archetypal and common regimes, self-regulated mechanical feedback and a quasar thermal blast. We find that AGN feedback has severe difficulty in breaking the relation in a consistent way. The similarity breaking is directly linked to the gas evacuation within $R_{500}$, while the central cooling times are inversely proportional to the core density. Breaking self-similarity implies thus breaking the cool core, morphing all systems to non-cool-core objects, which is in clear contradiction with the observed data populated by several cool-core systems. Self-regulated feedback, which quenches cooling flows and preserves cool cores, prevents the dramatic evacuation and similarity breaking at any scale; the relation scatter is also limited. The impulsive ...

  20. CP breaking in lattice chiral gauge theories

    International Nuclear Information System (INIS)

    The CP symmetry is not manifestly implemented for the local and doubler-free Ginsparg-Wilson operator in lattice chiral gauge theory. We precisely identify where the effects of this CP breaking appear. We show that they appear in: (I) Overall constant phase of the fermion generating functional. (II) Overall constant coefficient of the fermion generating functional. (III) Fermion propagator appearing in external fermion lines and the propagator connected to Yukawa vertices. The first effect appears from the transformation of the path integral measure and it is absorbed into a suitable definition of the constant phase factor for each topological sector; in this sense there appears no 'CP anomaly'. The second constant arises from the explicit breaking in the action and it is absorbed by the suitable weights with which topological sectors are summed. The last one in the propagator is inherent to this formulation and cannot be avoided by a mere modification of the projection operator, for example, in the framework of the Ginsparg-Wilson operator. This breaking emerges as an (almost) contact term in the propagator when the Higgs field, which is treated perturbatively, has no vacuum expectation value. In the presence of the vacuum expectation value, however, a completely new situation arises and the breaking becomes intrinsically non-local, though this breaking may still be removed in a suitable continuum limit. This non-local CP breaking is expected to persist for a non-perturbative treatment of the Higgs coupling. (author)