WorldWideScience

Sample records for bp010009 cambridge biotech

  1. Biotech as 'Biothreat'?

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte

    2008-01-01

    a more comprehensive frame for explaining the function of metaphor in use, and an empirical part analysing biotech-metaphors in the Danish print press. Although not conclusive, the analysis points to metaphorical constructions in the press being both grounded in basic image schematic structures...

  2. Voices of biotech

    DEFF Research Database (Denmark)

    Amit, Ido; Baker, David; Barker, Roger

    2016-01-01

    What will be the most important areas of research in biotech over the coming years? Which technologies will be most important to advance knowledge and applications in these areas? Nature Biotechnology reached out to a set of investigators working in research areas representative of the journal...

  3. Profiles of four projects in Biotech Business

    DEFF Research Database (Denmark)

    Valentin, Finn

    2004-01-01

    In April 2004, Copenhagen Business School opens a centre for research on biotech business. Biotech Business includes a number of senior and junior researchers from CBS. Initially the centre takes its point of departure in four projects included in the research program on Competence, Organisation...... and Management in Biotech Industries (COMBI). Starting in March 2004, COMBI is funded jointly by The Danish Social Research Council, firms and organisations in the Danish biotech industry and CBS. This presentation refers exclusively to four COMBI projects....

  4. A global need for women's biotech leadership

    DEFF Research Database (Denmark)

    Smith-Doerr, L.; Kemekliene, G.; Teutonico, R.

    2011-01-01

    Increasing women's participation in leadership of biotech policy making, funding, research and implementation will strengthen the race to solve global problems......Increasing women's participation in leadership of biotech policy making, funding, research and implementation will strengthen the race to solve global problems...

  5. Structure, Employment and Performance in Biotech Firms

    DEFF Research Database (Denmark)

    Valentin, Finn; Dahlgren, Johan Henrich; Lund Jensen, Rasmus

    2006-01-01

    biotech firms in a relevant context we compare a Danish segment of biotech firms with a matching Swedish segment.From an overall assessment modern biotechnology, despite the three decades elapsed since the first genetic manipulation, is still in a stage of experimentation, learning how to turn its new...... tools and approaches into an operational, reliable, cost-effective technology, sufficiently `pluggable' with other technologies. Therefore employment directly related to biotech is particularly visible and identifiable in firms focused on R&D. Outside this core of R&D activity other industries appear...... as early adopters of biotech, but only parts of their activities relate to modern biotechnology. From the outside it is difficult to isolate what share of their employment is attributable to their activities within biotechnology.In pursuit of clarity on the role of biotechnology this report studies...

  6. Business Ethics 101 for the biotech industry.

    Science.gov (United States)

    MacDonald, Chris

    2004-01-01

    Biotechnology companies face ethical challenges of two distinct types: bioethical challenges faced on account of the nature of work in the life sciences, and corporate ethical challenges on account of their nature as commercial entities. The latter set of challenges has received almost no attention at all in the academic literature or media. This paper begins to remedy that lacuna, examining ethical issues that arise specifically on account of the status of biotech companies as commercial entities. The focus here is on three representative issues: product safety, corporate social responsibility, and corporate governance. It is argued that each of these issues poses particular ethical challenges for companies in the biotech sector. In the area of product safety, it is noted that biotech companies face particular challenges in determining what counts as a "safe" product, given the contentious nature of what might count as a "harm" in the biotech field. In the area of corporate social responsibility, the adoption of a "stakeholder approach" and an attempt to manage the social consequences of products pose special challenges for biotech companies. This is due to the enormous range of groups and individuals claiming to have a stake in the doings of such companies, and the trenchant controversies over just what the social consequences of various biotechnologies might be. In the area of corporate governance, biotech companies need to seek out and follow best practices regarding the ways in which information, authority, and influence flow between a company's shareholders, managers, and Board of Directors, if they are to avoid duplicating the ethical and financial scandal that brought down ImClone. An important meta-issue, here--one that renders each of these corporate ethical challenges more vexing--is the difficulty of finding the appropriate benchmarks for ethical corporate behavior in a field as controversial, and as rapidly evolving, as biotechnology. Three

  7. Neuro-oncology biotech industry progress report.

    Science.gov (United States)

    Chakraborty, Shamik; Bodhinayake, Imithri; Chiluwal, Amrit; Langer, David J; Ruggieri, Rosamaria; Symons, Marc; Boockvar, John A

    2016-05-01

    The Brain Tumor Biotech Center at the Feinstein Institute for Medical Research, in collaboration with Voices Against Brain Cancer hosted The Brain Tumor Biotech Summit at in New York City in June 2015. The focus was once again on fostering collaboration between neuro-oncologist, neurosurgeons, scientists, leaders from biotechnology and pharmaceutical industries, and members of the financial community. The summit highlighted the recent advances in the treatment of brain tumor, and specifically focused on targeting of stem cells and EGFR, use of prophage and immunostimulatory vaccines, retroviral vectors for drug delivery, biologic prodrug, Cesium brachytherapy, and use of electric field to disrupt tumor cell proliferation. This article summarizes the current progress in brain tumor research as presented at 2015 The Brain Tumor Biotech Summit.

  8. Entrepreneurial culture in innovative biotech clusters.

    NARCIS (Netherlands)

    Ruel, Hubertus Johannes Maria; Frolova, P.; Groen, Arend J.

    2012-01-01

    This paper presents a study on the determinants of entrepreneurial culture in innovative biotech clusters. A literature review led to the identification of nine determinants. For the empirical study four clusters in Western Europe with a high entrepreneurial culture were selected. Cluster

  9. Perspective: Biotech funding trends: Insights from entrepreneurs and investors.

    Science.gov (United States)

    Gruber, Alexandra C

    2009-08-01

    Based on a qualitative study analyzing a series of interviews with dedicated biotech entrepreneurs and high-level investors, "Biotech Funding Trends" provides a comprehensive overview of current trends in biotech funding by taking a close look behind the scenes of the biotech industry. In particular, it illustrates the tensions between both key players based on their different backgrounds and expectations. Here we outline the various funding opportunities for the biotech industry in Europe and identify ways for both sides, entrepreneurs and investors to overcome their prejudices to successfully thrive in a competitive environment. The results are also discussed in the light of the current financial and economic crisis.

  10. Communicating financials in the biotech industry

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte

    2008-01-01

    , Novozymes. Research indicates that besides accommodating a legal demand for the disclosure of company financial details, the annual report, in particular the letter to the shareholders or the CEO's letter, serves the purpose of marketing the company to its constituents (Bowman 1984; Bülow-Møller 2003......In Denmark, biotechnology and its physical product, the genetically modified organism, continues to be controversial, leading to widespread public scepticism. This paper explores the effect of such scepticism on part of the financial communication of one of Denmark's largest biotech companies......; Hyland 1998). This point is arguably of more importance to a biotech company which in its communication to the public may have to consider promoting an overly favourable and trustworthy image not only of its financial results, but also of the industry in which it is engaged, to ensure continuous...

  11. The Cambridge Experiment

    Directory of Open Access Journals (Sweden)

    Marco Iuliano

    2014-09-01

    Full Text Available Since the latter part of 19th century photography has played a central role in the development of architecture for its persuasive visual impact. But, despite this clear interaction, there is still reluctance from scholars in accepting less rigid approaches to the two disciplines. Indeed, the combination of the subjects, with the necessary rigour, can open up new and effective horizons for architectural history, with a potential influence on the perceived reality: this could gradually establish attention towards less known heritage. In the case we present here, by means of a provocative exhibition on Cambridge’s buildings after the Second World War, we have used photography to re-evaluate modern architecture. Cambridge in Concrete. Images from the RIBA British Architectural Library Photographs Collection, was held on the occasion of the University of Cambridge Department of Architecture’s Centenary (1912-2012. The cues for our task were contained in the collections of the Royal Institute of British Architects: the photographic archive is the world’s biggest holding of architectural images which, since 2012, has been renamed in honour of Robert Elwall (1953-2012, first curator of the collection. As part of the exhibition we published a limited edition catalogue; we have here revisited, combined and enlarged our original essays.

  12. 76 FR 17621 - Biotech Life Science Trade Mission to China

    Science.gov (United States)

    2011-03-30

    ... Medicine), which possesses excellent research facilities and business infrastructure, regulatory linkages... trials in Asia. The Biotech Life Science Sector Despite the global financial crisis, China's GDP growth...

  13. Fourth Medical Biotech Forum of the Chinese Medical Biotech Association. 8-10 August 2009, Dalian, China.

    Science.gov (United States)

    Felzmann, Thomas

    2009-10-01

    The Chinese Medical Biotech Association's Fourth Medical Biotech Forum held in Dalian, China included topics covering the biotechnology industry in China and new therapeutic developments in the field of immunological approaches to cancer treatment. This conference report highlights selected presentations on China's biotechnology development policy, tumor-specific antigens, clinical applications of antitumor immune therapy, and novel photodynamic tumor therapy. Investigational therapeutics discussed include astuprotimut-r (GlaxoSmithKline plc) and the dendritic cell vaccine Trivax (Trimed Biotech).

  14. 77 FR 35353 - Biotech Life Sciences Trade Mission to Australia

    Science.gov (United States)

    2012-06-13

    ... International Trade Administration Biotech Life Sciences Trade Mission to Australia AGENCY: International Trade... Biotech Life Sciences trade mission to Australia, October 29-November 2, 2012. The mission to Australia is... of the trade mission to Australia are to (1) increase U.S. exports to Australia, (2) introduce U.S...

  15. International Commercial Contracts, by Giuditta Cordero Moss. (Cambridge: Cambridge University Press, 2014)

    DEFF Research Database (Denmark)

    Lando, Ole

    2015-01-01

    Review of: Giuditta Cordero Moss, International Commercial Contracts. Cambridge: Cambridge University Press, 2014. XV + 329 pages. ISBN: 9781107684713......Review of: Giuditta Cordero Moss, International Commercial Contracts. Cambridge: Cambridge University Press, 2014. XV + 329 pages. ISBN: 9781107684713...

  16. Indian Biotech Bazaar: a swot analysis.

    Science.gov (United States)

    Kumar, Abhishek

    2007-05-01

    Biotechnology is a life science-based technique especially used in agriculture, medicine and food sciences. It is generally defined as the manipulation in organisms to generate products for the welfare of the world. Biotechnology combines disciplines such as genetics, biochemistry, microbiology, and cell biology along with information technology, chemical engineering, robotics etc. It includes basic industries such as food processing, tissue culture, plant development and other sophisticated ones such as recombinant therapeutics and diagnostics. Biotechnology, globally recognized as a rapidly emerging and far-reaching technology, is aptly described as the "technology of hope" for its promise of food, health and environmental sustainability. In India, biotechnology employs more than 10 000 people and generates roughly US$ 500 million in revenue annually. The biotechnology market has increased its sales from Rs. 50 billion in 1997 to Rs.70 billion in 2000, and is expected to cross Rs. 240 billion by the year 2010. In India, the human health biotech products account for 60% of the total market; agribiotech and veterinary 25%, medical devices, contract research and development (R&D), reagents and supplies constitute the remaining 15% Moreover, to facilitate foreign investment, capital and government policies are being revised. Other important industries include industrial enzyme manufacture, bioinformatics, and medical devices. Biotechnology has had limited appeal so far on our capital markets, and we have less then a dozen biotech companies listed on the public markets.

  17. The Cambridge Structural Database.

    Science.gov (United States)

    Groom, Colin R; Bruno, Ian J; Lightfoot, Matthew P; Ward, Suzanna C

    2016-04-01

    The Cambridge Structural Database (CSD) contains a complete record of all published organic and metal-organic small-molecule crystal structures. The database has been in operation for over 50 years and continues to be the primary means of sharing structural chemistry data and knowledge across disciplines. As well as structures that are made public to support scientific articles, it includes many structures published directly as CSD Communications. All structures are processed both computationally and by expert structural chemistry editors prior to entering the database. A key component of this processing is the reliable association of the chemical identity of the structure studied with the experimental data. This important step helps ensure that data is widely discoverable and readily reusable. Content is further enriched through selective inclusion of additional experimental data. Entries are available to anyone through free CSD community web services. Linking services developed and maintained by the CCDC, combined with the use of standard identifiers, facilitate discovery from other resources. Data can also be accessed through CCDC and third party software applications and through an application programming interface.

  18. Reflections on Cambridge: John Maynard Keynes at King's College Cambridge

    OpenAIRE

    Macfarlane, Alan

    2012-01-01

    .mp4 video file The economist John Maynard Keynes spent much of his life in Cambridge, connected to King's College. Alan Macfarlane reflects on a few aspects of his life and work. Filmed by Xu Bei in 2010

  19. Early-stage biotech companies: strategies for survival and growth.

    Science.gov (United States)

    Tsai, Wendy; Erickson, Stanford

    2006-06-01

    The promise of start-up biotechnology companies is enormous. So are the risks and the uncertainty of product development. The authors present a checklist for young biotech companies, covering environmental factors, alliances, and strategic planning.

  20. Clark and Prehistory at Cambridge

    Directory of Open Access Journals (Sweden)

    Pamela Jane Smith

    1996-05-01

    Full Text Available If honours and titles give measure of a man, then Professor Sir Grahame Clark was indeed important. Faculty Assistant Lecturer in the Faculty of Archaeology and Anthropology at Cambridge University from 1935-46, University Lecturer 1946-52, Disney Professor of Archaeology 1952-74, Head of the Department of Archaeol­ogy and Anthropology 1956-61 and 1968-71, Fellow of Peterhouse, Cambridge 1950-73, Master of Peterhouse 1973-80, he was a visiting lecturer at diverse universities; appointed CBE in 1971, he received many awards includ­ing the prestigious Erasmus Prize for 1990, presented by Prince Bernhard of the Netherlands, for his "long and inspiring devotion to prehistory" (Scarre 1991:10; and in June 1992, he was knighted. Yet well before fame and position were rewards, Clark made major contributions to the establishment of prehis­tory as an academic subject at Cambridge University. Cambridge was the first and, for many years, only British university granting an undergraduate degree which offered prehistory as a specialization. "The development of postgraduate research in prehistoric archaeology at Cambridge had to wait on the provision of undergraduate teaching;' Clark (1989b: 6 recently observed. The "faculty was the only one in Britain producing a flow of graduates in prehistoric archaeology" (Clark 1989a: 53.

  1. Cambridge IGCSE English first language

    CERN Document Server

    Reynolds, John

    2013-01-01

    Revised edition for the 2015 syllabus to help your students prepare for their examination and enhance their enjoyment of English. This title has been written for the revised Cambridge IGCSE First Language English (0500 and 0522) syllabuses, for first teaching from 2013. ? Develops the skills necessary to become a better reader and writer. ? Offers detailed advice and preparation for the examination. ? Teaches skills for successful writing of essays and coursework assignment. We are working with Cambridge International Examinations to gain endorsement for this title.

  2. The Cambridge encyclopaedia of astronomy

    CERN Document Server

    1977-01-01

    Astronomy has been transformed in the last two decades by a series of dramatic discoveries that have left most reference books completely out of date. The Cambridge Encyclopaedia of Astronomy presents a broadly based survey of the whole of astronomy which places emphasis on these critical new findings.

  3. 77 FR 14852 - Advanced Growing Systems, Inc., Advantage Capital Development Corp., Amazon Biotech, Inc...

    Science.gov (United States)

    2012-03-13

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Advanced Growing Systems, Inc., Advantage Capital Development Corp., Amazon Biotech, Inc., Andover... of current and accurate information concerning the securities of Amazon ] Biotech, Inc. because it...

  4. 33 CFR 117.549 - Cambridge Harbor.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cambridge Harbor. 117.549 Section... DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Maryland § 117.549 Cambridge Harbor. The draw of the S342 bridge, mile 0.1 at Cambridge, shall open on signal from 6 a.m. to 8 p.m.; except that, from 12...

  5. 77 FR 3118 - Security Zone; Choptank River and Cambridge Channel, Cambridge, MD

    Science.gov (United States)

    2012-01-23

    ... No. USCG-2011-1164] RIN 1625-AA87 Security Zone; Choptank River and Cambridge Channel, Cambridge, MD... temporary security zone encompassing certain waters of the Choptank River and Cambridge Channel in order to... will be held at the Hyatt Regency Chesapeake Bay Golf Resort, Spa and Marina in Cambridge, Maryland...

  6. Scientific knowledge dynamics and relatedness in biotech cities

    NARCIS (Netherlands)

    Boschma, Ron|info:eu-repo/dai/nl/123155541; Heimeriks, Gaston|info:eu-repo/dai/nl/291061664; Balland, Pierre-Alexandre|info:eu-repo/dai/nl/330821369

    2014-01-01

    This paper investigates the impact of scientific relatedness on knowledge dynamics in biotech at the city level during the period 1989-2008. We assess the extent to which the emergence of new research topics and the disappearance of existing topics in cities are dependent on their degree of

  7. Impact of America Invents Act on Biotech Intellectual Property.

    Science.gov (United States)

    Murphy, Amanda; Stramiello, Michael; Stroud, Jonathan; Lewis, Stacy; Irving, Tom

    2015-04-27

    This review introduces the America Invents Act (AIA), a comprehensive reform of U.S. law on patentability and patent enforceability that Congress enacted in 2011. The AIA's most publicized change transforms the United States from a "first-to-invent" system to a "first-inventor-to-file" regime, bringing U.S. patent law more in line with the patent systems of nearly every other industrialized country in the world. This new system requires small companies and independent inventors to toe the line against larger competitors in what many have called a "race to the patent office." But a closer look at the AIA reveals several opportunities for smaller entities that may even the playing field, particularly for innovators in the biotech sector. This article addresses changes that the AIA brings to U.S. patent law, keeping an eye toward issues relevant to biotech companies. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

  8. Industry progress report on neuro-oncology: Biotech update 2013.

    Science.gov (United States)

    Ottenhausen, Malte; Bodhinayake, Imithri; Banu, Matei; Kesavabhotla, Kartik; Ray, Ashley; Boockvar, John A

    2013-11-01

    For the second time, The Brain Tumor Center of the Weill Cornell Brain and Spine Center, in collaboration with Voices Against Brain Cancer, hosted The Brain Tumor Biotech Summit in New York City in June 2013. After a very successful first summit in 2012, this innovative event has established a platform for intensive networking between neuro-oncologists, neurosurgeons, neuroscientists, members of the biotechnology and pharmaceutical communities, members of the financial community and leaders of non-profit organizations. This year's summit highlighted dendritic cell vaccines, novel antibody, heat shock protein and targeted therapies as well as exosome technologies, MRI-guided therapies and other novel drug delivery tools. This report presents a short overview of the current progress in brain tumor research and therapy as presented at the 2013 Brain Tumor Biotech Summit.

  9. Ethical reasons for narrowing the scope of biotech patents.

    Science.gov (United States)

    Andreassen, Tom

    2015-11-01

    Patents on biotech products have a scope that goes well beyond what is covered by the most widely applied ethical justifications of intellectual property. Neither natural rights theory from Locke, nor public interest theory of IP rights justifies the wide scope of legal protection. The article takes human genes as an example, focusing on the component that is not invented but persists as unaltered gene information even in the synthetically produced complementary DNA, the cDNA. It is argued that patent on cDNA holds this information captive, or illegitimately appropriates it in limiting other researchers and inventors' opportunity to explore new functions and uses based on this non-invented information. A tighter connection between legal IP protection and the use description stated in the patent claim is suggested. By binding protection to the product's foreseeable functions and use, instead of the product itself and all future uses of it, legitimacy of biotech product patents is restored.

  10. Competing business models in the french biotech industry

    OpenAIRE

    Mangematin, Vincent

    2000-01-01

    Public authorities have recently supported development of the biotechnology sector by encouraging start-ups and creating favourable environments such as incubators, a specialised stock exchange or technopoles. The different programmes to encourage biotech development (subsidies for research performed jointly by firms and academic labs, subsidies for start-ups, creation of incubators) seem to be successful if the results are estimated in terms of the number of new firms (around 300 SMEs still ...

  11. Trial access to Cambridge University Press ebooks

    CERN Multimedia

    CERN Library

    2011-01-01

    From 1 August till 31 October, CERN users are invited to enjoy a trial access to all Cambridge University Press electronic books: http://ebooks.cambridge.org/. Please don't hesitate to send feedback to library.desk@cern.ch.

  12. Industry progress report on neuro-oncology: a biotech update.

    Science.gov (United States)

    Haber, Jessica S; Banu, Matei A; Ray, Ashley; Kesavabhotla, Kartik; Boockvar, John A

    2013-04-01

    With steadily rising revenue and large numbers of clinical trials utilizing novel treatment strategies, the field of neuro-oncology is at the core of the growing cancer therapy industry. In June 2012, the Weill Cornell Brain and Tumor Center hosted the first Brain Tumor Biotech Summit as a forum for fostering and encouraging collaboration between researches and investors to accelerate novel treatments for brain cancer. This event brought together neuro-oncologists, neurosurgeons, academicians, entrepreneurs, non-profits, CEOs and investors in an attempt to bring innovative treatments and concepts to the fore. Specific subjects presented at the meeting included new surgical devices and delivery techniques, targeted therapeutics, immunotherapy, and stem cell biology. The mission of the summit was to provide opportunities for researchers in neuro-oncology to directly interact with leaders from the investment community with insight into the commercial aspects of our work. Our shared goal is to shorten the time for basic science ideas to be translated into the clinical setting. The following serves as a progress report on the biotech industry in neuro-oncology, as presented at the Brain Tumor Biotech Summit.

  13. Biotech 101: an educational outreach program in genetics and biotechnology.

    Science.gov (United States)

    East, Kelly M; Hott, Adam M; Callanan, Nancy P; Lamb, Neil E

    2012-10-01

    Recent advances in research and biotechnology are making genetics and genomics increasingly relevant to the lives and health of the general public. For the public to make informed healthcare and public policy decisions relating to genetic information, there is a need for increased genetic literacy. Biotech 101 is a free, short-course for the local community introducing participants to topics in genetics, genomics, and biotechnology, created at the HudsonAlpha Institute for Biotechnology. This study evaluated the effectiveness of Biotech 101 in increasing the genetic literacy of program participants through pre-and-post surveys. Genetic literacy was measured through increases in self-perceived knowledge for each content area covered through the course and the self-reported impact the course had on various aspects of participants' lives. Three hundred ninety-two individuals attended Biotech 101 during the first three course offerings. Participants reported a significant increase in self-perceived knowledge for each content area (p genetic literacy and serves as a model for other similar programs, adding to the currently limited evidence base regarding public educational strategies in genetics and biotechnology.

  14. The Cambridge Behavioural Inventory revised

    Directory of Open Access Journals (Sweden)

    Helen J. Wear

    Full Text Available Abstract Neurobehavioural and psychiatric symptoms are common in a range of neurodegenerative disorders with distinct profiles which are helpful in the diagnosis and monitoring of these disorders. The Cambridge Behavioural Inventory (CBI has been shown to distinguish frontotemporal dementia (FTD, Alzheimer's disease (AD, Huntington's disease (HD and Parkinson's disease (PD, but it is lengthy. Objective: To develop a shorter version of the 81 item CBI. Methods: CBI data from 450 participants with behavioural variant frontotemporal dementia (bv-FTD (64, AD (96, PD (215 and HD (75 were analysed using Principal Components Analysis and measures of internal consistency (Cronbach alpha. Results: A reduced 45-item questionnaire was developed. The instrument identified distinct behavioural profiles and performed as well as the original version. Conclusions: A shorter (45 item version of the CBI is capable of differentiating bv-FTD and AD from PD and HD. It may be useful in delineating the type and extent of problems in these disorders as well as monitoring therapeutic interventions.

  15. Cambridge community Optometry Glaucoma Scheme.

    Science.gov (United States)

    Keenan, Jonathan; Shahid, Humma; Bourne, Rupert R; White, Andrew J; Martin, Keith R

    2015-04-01

    With a higher life expectancy, there is an increased demand for hospital glaucoma services in the United Kingdom. The Cambridge community Optometry Glaucoma Scheme (COGS) was initiated in 2010, where new referrals for suspected glaucoma are evaluated by community optometrists with a special interest in glaucoma, with virtual electronic review and validation by a consultant ophthalmologist with special interest in glaucoma. 1733 patients were evaluated by this scheme between 2010 and 2013. Clinical assessment is performed by the optometrist at a remote site. Goldmann applanation tonometry, pachymetry, monoscopic colour optic disc photographs and automated Humphrey visual field testing are performed. A clinical decision is made as to whether a patient has glaucoma or is a suspect, and referred on or discharged as a false positive referral. The clinical findings, optic disc photographs and visual field test results are transmitted electronically for virtual review by a consultant ophthalmologist. The number of false positive referrals from initial referral into the scheme. Of the patients, 46.6% were discharged at assessment and a further 5.7% were discharged following virtual review. Of the patients initially discharged, 2.8% were recalled following virtual review. Following assessment at the hospital, a further 10.5% were discharged after a single visit. The COGS community-based glaucoma screening programme is a safe and effective way of evaluating glaucoma referrals in the community and reducing false-positive referrals for glaucoma into the hospital system. © 2014 Royal Australian and New Zealand College of Ophthalmologists.

  16. Social Network Analysis of the Irish Biotech Industry: Implications for Digital Ecosystems

    Science.gov (United States)

    van Egeraat, Chris; Curran, Declan

    This paper presents an analysis of the socio-spatial structures of innovation, collaboration and knowledge flow among SMEs in the Irish biotech sector. The study applies social network analysis to determine the structure of networks of company directors and inventors in the biotech sector. In addition, the article discusses the implications of the findings for the role and contours of a biotech digital ecosystem. To distil these lessons, the research team organised a seminar which was attended by representatives of biotech actors and experts.

  17. Implementation of the resource recovery concept in the biotech industry

    DEFF Research Database (Denmark)

    Mitic, Aleksandar; Mansouri, Seyed Soheil; S.B.A. Udugama, Isuru

    The concept of circular economy is attracting significant attention in modern biotech industry. Downstream processing plants are usually focused on the removal of impurities instead of their recovery in the form of value-added products for additional revenues. For example, carboxylic acids...... additives, cosmetics, medical products, bio-based plastics, bio-fuels (biogas, bioethanol and biodiesel), fertilizers, and even biopharmaceuticals......., carbohydrates, proteins, lipids, inorganic ions and water itself are amongst various resources that are found in wastewater streams coming from bio-based production processes. Such compounds have a high value at the global market and could potentially be used as raw materials for the manufacturing feed and food...

  18. Deutsche Biotech-Unternehmen und ihre Innovationsfähigkeit im internationalen Vergleich : eine institutionentheoretische Analyse

    NARCIS (Netherlands)

    Lange, K.S.G.

    2006-01-01

    German Biotech-Companies and their Innovativeness in International Comparison – an Institutionalist Analysis 1 Introduction In the mid-1990s, legal changes and policy initiatives in Germany led to the rapid emergence of a biotechnology industry. Initially, German biotech companies focused on the

  19. The path- and place-dependent nature of scientific knowledge production in biotech 1986-2008

    NARCIS (Netherlands)

    Heimeriks, G.J.; Boschma, R.

    2013-01-01

    This study explores the worldwide spatial evolution of scientific knowledge production in biotechnology in the period 1986–2008. We employ new methodology that identifies new key topics in biotech on the basis of frequent use of title worlds in major biotech journals as an indication of new

  20. The path- and place-dependent nature of scientific knowledge production in biotech 1986-2008

    NARCIS (Netherlands)

    Heimeriks, Gaston|info:eu-repo/dai/nl/291061664; Boschma, Ron|info:eu-repo/dai/nl/123155541

    2014-01-01

    This study explores the worldwide spatial evolution of scientific knowledge production in biotechnology in the period 1986-2008. We employ new methodology that identifies new key topics in biotech on the basis of frequent use of title worlds in major biotech journals as an indication of new

  1. A global overview of biotech (GM) crops: adoption, impact and future prospects.

    Science.gov (United States)

    James, Clive

    2010-01-01

    In the early 1990s, some were skeptical that genetically modified (GM) crops, now referred to as biotech crops, could deliver improved products and make an impact at the farm level. There was even more skepticism that developing countries would adopt biotech crops. The adoption of and commercialization of biotech crops in 2008 is reviewed. The impact of biotech crops are summarized including their contribution to: global food, feed and fiber security; a safer environment; a more sustainable agriculture; and the alleviation of poverty, and hunger in the developing countries of the world. Future prospects are discussed. Notably, Egypt planted Bt maize for the first time in 2008 thereby becoming the first country in the Arab world to commercialize biotech crops.

  2. 76 FR 13665 - Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH...

    Science.gov (United States)

    2011-03-14

    ... Employment and Training Administration Cambridge Tool & Die, Including On-Site Leased Workers From Action Total Staffing, Cambridge, OH; Amended Certification Regarding Eligibility To Apply for Worker... ] Assistance on January 13, 2011, applicable to workers of Cambridge Tool & Die, Cambridge, Ohio. The workers...

  3. Cambridge IGCSE mathematics core and extended

    CERN Document Server

    Pimentel, Ric

    2013-01-01

    The most cost effective and straightforward way to teach the revised syllabus, with all the core and extended content covered by a single book and accompanying free digital resources.  . This title has been written for the revised Cambridge IGCSE Mathematics (0580) syllabus, for first teaching from 2013.  . ·         Gives students the practice they require to deepen their understanding through plenty of questions. ·         Consolidates learning with unique digital resources on the CD, included free with every Student's Book.  . We are working with Cambridge International Examinations to gain

  4. Biotech pilgrims and the transnational quest for stem cell cures.

    Science.gov (United States)

    Song, Priscilla

    2010-10-01

    Thousands of patients with incurable neurodegenerative conditions from more than 60 countries have sought fetal cell transplants in China since 2001. Drawing on 24 months of ethnographic fieldwork, I investigate these transnational encounters occurring in the realm of experimental medicine. Critiquing popular notions of "medical tourism," I develop the alternative concept of "biotech pilgrimage" to reveal how faith intertwines with technology, travel, and the political economies of health care and medical research in a global era. Insights from pilgrimage theory enable us to question assumptions of leisure embedded in claims of tourism while also exploring new biopolitical practices that extend beyond the borders of the nation-state. I also demonstrate how materialist visions of salvation underlie medical practice and contribute to China's rising influence as a global technological leader.

  5. Shaking Up Biotech/Pharma: Can Cues Be Taken from the Tech Industry?

    Science.gov (United States)

    Wang, C Katherine

    2017-06-01

    The biotech and pharma (biotech/pharma) industry is in dire need of finding ways to increase efficacy, efficiency, and affordability of its products. The information and technology industry ("tech") industry, which is an industry similarly founded on inventions and innovation, may provide some food for thought. This perspective will demonstrate the shift that biotech/pharma is already making and will propose that the industry has an opportunity to compel change by adopting some aspects of the tech industry with regards to models for technology/product development and leadership attributes.

  6. Surviving in biotech by own means : -if there is a will there is a way

    OpenAIRE

    Olsson Rousset, Ann; Wismenius, Anna

    2006-01-01

    Sweden is the fourth largest biotechnology country in Europe and Sweden has the highest number of biotech companies per capita in the world. The sector is not yet a well established one and there haven’t been much energy put on business research, why we wanted to explore the sector more thoroughly. The purpose of our investigation was to examine different ways to survive on your own in the biotech sector. The ways should work to copy for other actors in the biotech sector. Many variables have...

  7. Weizmann ties with Cambridge in physics contest

    CERN Multimedia

    Siegel, J

    2004-01-01

    "Scientists and students from the Weizmann Institute of Science in Rehovot and Cambridge University in England have tied for first place in a physics competition aimed at simulating the future functioning of the particle accelerator being built at the European center CERN and due to open in 2007" (1/2 page)

  8. 76 FR 12729 - Cambridge Environmental Inc; Transfer of Data

    Science.gov (United States)

    2011-03-08

    ... AGENCY Cambridge Environmental Inc; Transfer of Data AGENCY: Environmental Protection Agency (EPA... claimed as Confidential Business Information (CBI) by the submitter, will be transferred to Cambridge Environmental Inc. in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). Cambridge Environmental Inc. has been...

  9. book review the cambridge guide to african ano caribbean theatre.

    African Journals Online (AJOL)

    THE CAMBRIDGE GUIDE TO AFRICAN ANO CARIBBEAN. THEATRE. Edited by Martin Banham, Errol Hill and George Woodyard. Cambridge: Cambridge University Press, 1994, pp.24. 35 Pounds, $39.95. Six years after the Guide to World Theatre, which was "particularly designed to offer to scholars, students and general ...

  10. Biotech innovations in the prevention of respiratory infectious diseases.

    Science.gov (United States)

    Cento, Julia Valeria; Barbaliscia, Silvia; Perno, Carlo Federico

    2017-07-01

    Acute respiratory infections place a huge burden on society in terms of disability, premature mortality, and also direct health service costs (drugs prescriptions) and the indirect costs related to lost production. Therefore, prevention of respiratory infections is an important goal for public health interventions. In this context, silver nanoparticles (AgNPs) represent an interesting perspective for research and development by virtue of their favorable antimicrobial activity against many respiratory pathogens. One of the latest innovations in the biotech field discussed in this review is the creation of a biocompatible, biogel-based nasal filter enriched with AgNPs. Compared to traditional personal protective equipment (PPE), this type of nasal filter has the advantage of combining the antibacterial and antiviral activity of AgNPs with the common filtration capacity shared by other PPEs. This dual mechanism means that AgNP-enriched nasal filters serve to reduce the infecting microbial-load and protect the lower airways, without interfering with the normal respiratory capacity (airflow-resistance <5%). Given their antimicrobial characteristics and performance, AgNP-enriched nasal filters can meet many community and occupational currently unmet needs in the prevention of airborne infectious diseases, by ensuring an excellent respiratory-comfort and a continuous day-use.

  11. Alchemy in Cambridge. An Annotated Catalogue of Alchemical Texts and Illustrations in Cambridge Repositories.

    Science.gov (United States)

    Timmermann, Anke

    2015-01-01

    Alchemy in Cambridge captures the alchemical content of 56 manuscripts in Cambridge, in particular the libraries of Trinity College, Corpus Christi College and St John's College, the University Library and the Fitzwilliam Museum. As such, this catalogue makes visible a large number of previously unknown or obscured alchemica. While extant bibliographies, including those by M.R. James a century ago, were compiled by polymathic bibliographers for a wide audience of researchers, Alchemy in Cambridge benefits from the substantial developments in the history of alchemy, bibliography, and related scholarship in recent decades. Many texts are here identified for the first time. Another vital feature is the incorporation of information on alchemical illustrations in the manuscripts, intended to facilitate research on the visual culture of alchemy. The catalogue is aimed at historians of alchemy and science, and of high interest to manuscript scholars, historians of art and historians of college and university libraries.

  12. Trends in global approvals of biotech crops (1992-2014).

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

  13. Trends in global approvals of biotech crops (1992–2014)

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    ABSTRACT With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992–2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits. PMID:26039675

  14. The new Cambridge English course student 1

    CERN Document Server

    Swan, Michael

    1991-01-01

    The New Cambridge English Course is a course teachers and students can rely on to cover the complete range and depth of language and skills needed from beginner to upper-intermediate level. Each level is designed to provide at least 72 hours of class work using the Student's Book, with additional self-study material provided in the Practice Book. The course has a proven multi-syllabus approach which integrates work on all the vital aspects of language study: grammar, vocabulary, pronunciation, skills, notions and functions.

  15. Cambridge IGCSE english as a second language

    CERN Document Server

    Reynolds, John

    2014-01-01

    Revised edition for the 2015 syllabus offering the easiest and most cost effective way to teach both the speaking and listening components with one set of books covering two years and free digital material. This title has been written for the revised Cambridge IGCSE English as a Second Language (0510 and 0511) syllabuses, for first teaching from 2013. ? Prepares students for their exams with a focus on assessed language features, such as inference, opinion and attitude. ? Develops language abilities at an appropriate pace with extra interactive tests on a free CD-ROM. We are working with Cambr

  16. The Cambridge CFD Grid for Large Scale Distributed CFD Applications

    OpenAIRE

    Yang, Xiaobo; Hayes, Mark; Jenkins, K.; Cant, Stewart R.

    2005-01-01

    A revised version submitted for publication in the Elsevier Journal of Future Generation Computer Systems: promotional issue on Grid Computing, originally appeared in the Proceedings of ICCS 2004, Krakow, Poland, June 2004 The Cambridge CFD (computational fluid dynamics) Grid is a distributed problem solving environment for large-scale CFD applications set up between the Cambridge eScience Centre and the CFD Lab in the Engineering Department at the University of Cambridge. A Web portal, th...

  17. Parameters of Regional Cooperative Behavior in the German Biotech Industry – A Quantitative Social Network Analysis

    DEFF Research Database (Denmark)

    Mitze, Timo; Strotebeck, Falk

    We analyse the determinants of network formation in Germany’s biotechnology industry using social network analysis combined with a regression approach for count data. Outcome variable of interest is the degree centrality of German regions, which is specified as a function of the region’s innovative...... and economic performance as well as biotech-related policy variables. The inclusion of the latter allows us to shed new light on the question to what extent R&D-based cluster policies are able to impact on the formation of the German biotech network. Our results show that policy indicators such as the volume...

  18. Cambridge English First 2 with answers : authentic examination papers

    CERN Document Server

    2016-01-01

    Four authentic Cambridge English Language Assessment examination papers for the Cambridge English: First (FCE) exam. These examination papers for the Cambridge English: First (FCE) exam provide the most authentic exam preparation available, allowing candidates to familiarise themselves with the content and format of the exam and to practise useful exam techniques. The Student's Book is also available in a 'without answers' edition. Audio CDs (2) containing the exam Listening material and a Student's Book with answers and downloadable Audio are available separately. These tests are also available as Cambridge English: First Tests 5-8 on Testbank.org.uk

  19. Cambridge English First 2 audio CDs : authentic examination papers

    CERN Document Server

    2016-01-01

    Four authentic Cambridge English Language Assessment examination papers for the Cambridge English: First (FCE) exam. These examination papers for the Cambridge English: First (FCE) exam provide the most authentic exam preparation available, allowing candidates to familiarise themselves with the content and format of the exam and to practise useful exam techniques. The Audio CDs contain the recorded material to allow thorough preparation for the Listening paper and are designed to be used with the Student's Book. A Student's Book with or without answers and a Student's Book with answers and downloadable Audio are available separately. These tests are also available as Cambridge English: First Tests 5-8 on Testbank.org.uk

  20. The Whipple Museum and Cavendish Laboratory, Cambridge

    Science.gov (United States)

    Pippard, Brian

    The Whipple Museum is part of the History and Philosophy of Science Department in the University of Cambridge. It is on your right as soon as you enter Free School Lane from Pembroke Street, and is normally open between 1:30 and 4:30 P.M. on weekdays. The main room, a hall with hammer-beam roof, is a relic of Stephen Perse’s school (1624) now flourishing elsewhere in the city. It houses a large collection of mathematical, physical and astronomical instruments — abaci, Napier’s bones, slide rules; sextants and other surveying instruments; telescopes, compasses and pocket sundials (especially of ivory from Nuremberg 1500-1700); and a Grand Orrery by George Adams (1750). The gallery of a second room is used for special exhibitions, often of items from the well-stocked store. Some specialist catalogues have been compiled and are on sale.

  1. How Is Corporate Social Responsibility Addressed by Biotech Firms? a Case Study Analysis

    Science.gov (United States)

    Pérez-Bustamante, Guillermo

    2013-01-01

    This paper explores corporate social responsibility (CSR) in the biotech high-tech sector as a way to achieve competitive advantages. After presenting the importance of science for high-tech firms, the paper focuses on the social and economic role of CSR. Next, the primary reasons for firms' engagement in CSR activities are presented, followed by…

  2. Biotech/GM crops in horticulture: plum cv. HoneySweet resistant to plum pox virus

    Science.gov (United States)

    Commercialization of Biotech crops started in 1995. By 2011, genetically modified (GM) crops were grown world-wide on 160 million ha. Only 114.507 ha of GM crops were grown in Europe, of that, 114.490 ha were Bt maize and 17 ha were potato for industrial starch production. Currently, developing c...

  3. 77 FR 10598 - BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics...

    Science.gov (United States)

    2012-02-22

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION BIOTECH Holdings Ltd., California Oil & Gas Corp., Central Minera Corp., Chemokine Therapeutics... current and accurate information concerning the securities of California Oil & Gas Corp. because it has...

  4. Teachers Learning: Professional Development and Education. Cambridge Education Research Series

    Science.gov (United States)

    McLaughlin, Colleen, Ed.

    2012-01-01

    "Teachers Learning: Professional Development and Education" is part of The Cambridge Education Research series, edited by senior colleagues at the University of Cambridge Faculty of Education, which has a longstanding tradition of involvement in high quality, innovative teacher education and continuing professional development.…

  5. Recent Developments in Cambridge College Libraries

    Directory of Open Access Journals (Sweden)

    Alison Wilson

    2006-07-01

    Full Text Available Cambridge University has three tiers of libraries available to students: the University Library, departmental (subject libraries and college libraries. Over the past thirty years there has been increasing pressure on the colleges to provide more books, reader places and technical resources in their libraries, with the result that a number of new library buildings, of very different styles, have been opened. Other colleges have opted for refurbishment and extension of existing libraries. These libraries are small (30-100,000 books and intimate, often open 24 hours a day and with generous provision for lending books. Great importance is placed on keeping them at the heart of the college. Challenges for architects are the sensitive sites, restrictions on changes to listed buildings, and the limited space available. The constricted sites cause difficulties for the builders too. I will consider some solutions to these problems with reference to projects in four colleges: Pembroke, Peterhouse, Corpus Christi and Newnham. At Pembroke architects Freeland Rees Roberts have built an extension to a listed building and at Peterhouse they have adapted an adjoining room. Corpus Christi is moving its library to a Victorian building which has been internally redesigned by Wright + Wright. Newnham demolished a 1960s extension in order to develop the plot more efficiently to a design by John Miller + Partners. All the architects have shown sensitivity to the needs of their clients and ingenuity in making intensive use of limited space.

  6. Artificial Pancreas Project at Cambridge 2013.

    Science.gov (United States)

    Hovorka, R

    2015-08-01

    The development and clinical testing of closed-loop systems (the artificial pancreas) is underpinned by advances in continuous glucose monitoring and benefits from concerted academic and industry collaborative efforts. This review describes the progress of the Artificial Pancreas Project at the University of Cambridge from 2006 to 2014. Initial studies under controlled laboratory conditions, designed to collect representative safety and performance data, were followed by short to medium free-living unsupervised outpatient studies demonstrating the safety and efficacy of closed-loop insulin delivery using a model predictive control algorithm. Accompanying investigations included assessment of the psychosocial impact and key factors affecting glucose control such as insulin kinetics and glucose absorption. Translation to other disease conditions such as critical illness and Type 2 diabetes took place. It is concluded that innovation of iteratively enhanced closed-loop systems will provide tangible means to improve outcomes and quality of life in people with Type 1 diabetes and their families in the next decade. © 2015 The Author. Diabetic Medicine © 2015 Diabetes UK.

  7. Knowledge-Based Conformer Generation Using the Cambridge Structural Database.

    Science.gov (United States)

    Cole, Jason C; Korb, Oliver; McCabe, Patrick; Read, Murray; Taylor, Robin

    2018-02-09

    Fast generation of plausible molecular conformations is central to molecular modelling. This paper presents an approach to conformer generation that makes extensive use of the information available in the Cambridge Structural Database. By using geometric distributions derived from the Cambridge Structural Database, it is possible to create biologically relevant conformations in the majority of cases analysed. The paper compares the performance of the approach with previously published evaluations, and presents some cases where the method fails. The method appears to show significantly improved performance in reproduction of the conformations of structures observed in the Cambridge Structural Database and the Protein Data Bank as compared to other published methods of a similar speed.

  8. Competiveness and Innovation in High-tech Companies: an Application to the Italian Biotech and Aerospace Industries

    Directory of Open Access Journals (Sweden)

    Armando Calabrese

    2013-08-01

    research model proposed is applied to two high‐tech sectors of the Italian region of Lazio to verify its validity. The examination concerns the aerospace and biotech sectors, which are characterized by strong innovative activity.

  9. Cambridge Marketing College - interview about e-commerce

    OpenAIRE

    Paa-Kerner, Greta; Cambridge Marketing College

    2015-01-01

    Interview about e-commerce.\\ud \\ud The Cambridge Marketing College interviews Greta Paa-Kerner to learn about the dynamic world of e-commerce. She discusses online retail trends and shopping influencers.

  10. Knowledge management in the QbD paradigm: manufacturing of biotech therapeutics.

    Science.gov (United States)

    Herwig, Christoph; Garcia-Aponte, Oscar F; Golabgir, Aydin; Rathore, Anurag S

    2015-07-01

    In the quality by design (QbD) paradigm, global regulatory agencies have introduced the concepts of quality risk management and knowledge management (KM) as enablers for an enhanced pharmaceutical quality system. Although the concept of quality risk management has been well elucidated in the literature, the topic of KM has received relatively scant attention. In this paper we present an opinion on KM in the QbD paradigm as it relates to the manufacturing of biotech therapeutic products. Both academic and industrial viewpoints have been considered and key gaps have been elucidated. The authors conclude that there is an urgent need for the biotech industry to create efficient KM approaches if they wish to be successful in QbD implementation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Introduction to nano- and biotech-based materials for energy building efficiency

    OpenAIRE

    Torgal,Fernando Pacheco

    2016-01-01

    This chapter starts with an overview of the unsustainable energy consumption which is due to fast population growth and related greenhouse gas emissions. The case of energy efficiency building is introduced. A short analysis of the ambitious European nearly zero-energy building (NZEB) target is presented. Shortcomings of current materials concerning energy building efficiency are reviewed. Examples of promising nano- and biotech-based materials for energy building efficiency are briefly cover...

  12. Social Capital, ICT Use and Company Performance : Findings from the Medicon Valley Biotech Cluster

    OpenAIRE

    Steinfield, Charles; Scupola, Ada; López-Nicolás, Carolina

    2009-01-01

    This study explores how some kinds of ICT uses, as well as social capital and other means of access to knowledge resources, are related to company performance in a knowledge-intensive business cluster. Data were collected through a survey of companies in the Medicon Valley biotech region located in Denmark and Southern Sweden. Responding companies included established producers of biotechnology-related products as well as small biotechnology start-up firms emphasizing research and development...

  13. NTN Swiss Biotech - A Look at Support Measures for Dynamic Start-ups.

    Science.gov (United States)

    Heinzelmann, Elsbeth

    2016-01-01

    The Swiss biotech landscape seems to be on a healthy footing: There are many imaginative start-ups, we have first-class hospitals, highly advanced clinical research and the availability of a great deal of capital. But we have no reason to rest on our laurels as countries like the USA lead the field. We must lay down the tracks today to remain an attractive country and maintain our ranking among the 10 best locations.

  14. Michele Renee Salzman, Marvina A. Sweeney & William Adler (eds., The Cambridge History of Religions in the Ancient World (2 vols. (New York: Cambridge University Press, 2013

    Directory of Open Access Journals (Sweden)

    Giorgio Baruchello

    2014-03-01

    Full Text Available Review of: Michele Renee Salzman, Marvina A. Sweeney & William Adler (eds., The Cambridge History of Religions in the Ancient World (2 vols. (New York: Cambridge University Press, 2013

  15. Biotech crops: imperative for achieving the millenium development goals and sustainability of agriculture in the climate change era.

    Science.gov (United States)

    Husaini, Amjad M; Tuteja, Narendra

    2013-01-01

    Biotechnological intervention in the development of crops has opened new vistas in agriculture. Central to the accomplishment of the Millennium Development Goals (MDGs), biotech-agriculture is essential in meeting these targets. Biotech crops have already made modest contributions toward ensuring food and nutrition security by reducing losses and increasing productivity, with less pesticide input. These crops could help address some of the major challenges in agriculture-based economies created by climate change. Projections of global climate change expect the concentration of greenhouse gases to increase, aridization of the environment to increase, temperature fluctuations to occur sharply and frequently, and spatial and temporal distribution of rainfall to be disturbed-all of which will increase abiotic stress-related challenges to crops. Countering these challenges and to meet the food requirement of the ever-increasing world population (expected to reach 9 billion by 2030) we need to (1) develop and use biotech crops for mitigating adverse climatic changes; (2) develop biotech crops resilient to adverse environmental conditions; and (3) address the issues/non-issues raised by NGO's and educate the masses about the benefits of biotech crops.

  16. 8th Cambridge Workshop on Universal Access and Assistive Technology

    CERN Document Server

    Lazar, Jonathan; Heylighen, Ann; Dong, Hua

    2016-01-01

    This book presents the proceedings of the 8th Cambridge Workshop on Universal Access and Assistive Technology (CWUAAT '14), incorporating the 11th Cambridge Workshop on Rehabilitation Robotics, held in Cambridge, England in March 2016. It presents novel and state-of-the-art research from an international group of leaders in the fields of universal access and assistive technology. It explores various issues including the reconciliation of usability, accessibility and inclusive design, the design of inclusive assistive and rehabilitation systems, measuring product demand and human capabilities, data mining and visualizing inclusion, legislation in inclusive design, and situational inclusive interfaces (automotive and aerospace). This book provides an invaluable resource to researchers, postgraduates, design practitioners, therapists and clinical practitioners, as well as design teachers.

  17. Intelligence Inside the King’s College of Cambridge

    Directory of Open Access Journals (Sweden)

    Henriono Nugroho

    2008-11-01

    Full Text Available Article concerns with a stylistic analysis on a poem in terms of Systemic Functional Linguistics and Verbal Art Semiotics. The writing uses library research, qualitative data, documentary study, descriptive method and intrinsic-objective approach. The semantic analysis results in both automatized and foregrounded meanings. Then the automatized meaning produces lexical cohesion and in turn, it produces subject matter. Meanwhile, the foregrounded meaning produces the literary meaning and in turn, it creates theme. Finally, the analysis indicates that the subject matter is about the establishment of Cambridge University, the literary meaning is about eternal thoughts of Cambridge University, and the theme is about intelligence.

  18. Risks of allergic reactions to biotech proteins in foods: perception and reality.

    Science.gov (United States)

    Lehrer, S B; Bannon, G A

    2005-05-01

    In recent years, significant attention has been paid to the use of biotechnology to improve the quality and quantity of the food supply due in part to the projected growth in the world population, plus limited options available for increasing the amount of land under cultivation. Alterations in the food supply induced by classical breeding and selection methods typically involve the movement of large portions of genomic DNA between different plant varieties to obtain the desired trait. This is in contrast to techniques of genetic engineering which allows the selection and transfers specific genes from one species to another. The primary allergy risk to consumers from genetically modified crops may be placed into one of three categories. The first represents the highest risk to the allergic consumer is the transfer of known allergen or cross-reacting allergen into a food crop. The second category, representing an intermediate risk to the consumer, is the potential for replacing the endogenous allergenicity of a genetically-modified crop. The last category involves expression of novel proteins that may become allergens in man and generally represents a relatively low risk to the consumer, although this possibility has received attention of late. In order to mitigate the three categories of potential allergy risk associated with biotech crops, all genes introduced into food crops undergo a series of tests designed to determine if the biotech protein exhibits properties of known food allergens. The result of this risk assessment process to date is that no biotech proteins in foods have been documented to cause allergic reactions. These results indicate that the current assessment process is robust, although as science of allergy and allergens evolves, new information and new technology should help further the assessment process for potential allergenicity.

  19. Cambridge Illustrated History of Archaeology, edited by Paul G. Bahn, Cambridge University Press, New York, 1996

    Directory of Open Access Journals (Sweden)

    Douglas R. Givens

    1997-11-01

    Full Text Available The Cambridge Illustrated History of Archaeology is another in a series of volumes devoted to the history of archaeology that have appeared in recent time. Paul Bahn, the editor of the volume, has broken down his coverage of the history of worldwide archaeology into the following arrangement 'The Archaeology of Archaeology", "Old Worlds and New, 1500-1760", "Antiquarians and Explorers, 1760-1820", "Science and Romanticism, 1820-1860", "The Search for Human Origins, 1860-1920", "Archaeology Comes of Age, 1920-1960", "New Techniques and Competing Philosophies, 1960-1990",and "Current Controversies and Future Trends". Bahn's volume explores many of the major developments in archaeological practice from both in the classical world and was as from the practice of archaeology in the Americas. The volume even gives the reader a glimpse into the origins and growth of archaeology in New Zealand. Of particular interest is coverage of the history of early archaeological efforts having to do with early studies of human origins.

  20. Growth and profitability in small privately held biotech firms: preliminary findings.

    Science.gov (United States)

    Brännback, Malin; Carsrud, Alan; Renko, Maija; Ostermark, Ralf; Aaltonen, Jaana; Kiviluoto, Niklas

    2009-06-01

    This paper reports on preliminary findings on a study of the relationship of growth and profitability among small privately held Finnish Life Science firms. Previous research results concerning growth and profitability are mixed, ranging from strongly positive to a negative relationship. The conventional wisdom states that growth is a prerequisite for profitability. Our results suggest that the reverse is the case. A high profitability-low growth biotech firm is more probably to make the transition to high profitability-high growth than a firm that starts off with low profitability and high growth.

  1. The Cambridge Primary Review: A Reply to R. J. Campbell

    Science.gov (United States)

    Armstrong, Michael

    2010-01-01

    The author was disappointed by R. J. Campbell's sour critique of the Cambridge Primary Review in "FORUM" Volume 52 Number 1 2010. His description of the Review's proposals on curriculum and pedagogy as "backward-looking, cumbersome and partial" is such a bizarre misjudgement that it calls for some response. The author comments in turn on R. J.…

  2. Skype'i stipendium viib Cambridge'i / Kadri Bank

    Index Scriptorium Estoniae

    Bank, Kadri

    2006-01-01

    Eesti Infotehnoloogia Sihtasutuse (EITSA) Skype'i 100 000-kroonise magistristipendiumi sai Tartu Ülikooli matemaatika-informaatikateaduskonna kevadel lõpetanud Ago-Erik Riet, kes edestas kuut konkurenti ja asub õppima Cambridge'i Ülikooli magistrantuuri matemaatikat

  3. 77 FR 38086 - Manufacturer of Controlled Substances, Notice of Application, Cambridge Isotope Lab

    Science.gov (United States)

    2012-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application, Cambridge Isotope Lab... 7, 2012, Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application by...

  4. 78 FR 52802 - Manufacturer of Controlled Substances; Notice of Application; Cambridge Isotope Lab

    Science.gov (United States)

    2013-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cambridge Isotope Lab... 01, 2013, Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application by...

  5. 75 FR 38128 - Sensata Technologies MA, Inc., Power Controls Division, Formerly Known As Airpax Corp., Cambridge...

    Science.gov (United States)

    2010-07-01

    ... As Airpax Corp., Cambridge, Maryland, Including Employees of Sensata Technologies MA, Inc., Power Controls Division Formerly Known As Airpax Corp., Cambridge, Maryland Working Off-Site in Falmouth... known as Airpax Corporation, Cambridge, Maryland. The notice will soon be published in the Federal...

  6. 77 FR 64143 - Manufacturer of Controlled Substances; Notice of Registration; Cambridge Isotope Lab

    Science.gov (United States)

    2012-10-18

    ... Enforcement Administration Manufacturer of Controlled Substances; Notice of Registration; Cambridge Isotope..., Cambridge Isotope Lab, 50 Frontage Road, Andover, Massachusetts 01810, made application by renewal to the... registration of Cambridge Isotope Lab to manufacture the listed basic class of controlled substance is...

  7. 40 CFR 81.205 - Zanesville-Cambridge Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Zanesville-Cambridge Intrastate Air... Air Quality Control Regions § 81.205 Zanesville-Cambridge Intrastate Air Quality Control Region. The Zanesville-Cambridge Intrastate Air Quality Control Region (Ohio) consists of the territorial area...

  8. University of Cambridge deploys Procket Networks' PRO/8801

    CERN Document Server

    2003-01-01

    Procket Networks, a provider of high performance Internet Protocol (IP) technology and products has announced that the University of Cambridge has deployed the PRO/8801(TM) router into its research network to develop industry-leading deep packet inspection applications. The major application for this deployment is to identify and understand new traffic patterns created by large scale scientific computations and downloads such as the GRID (1 page).

  9. The industrial application requirement for biotech inventions in light of recent EPO & UK case law:

    DEFF Research Database (Denmark)

    Minssen, Timo; Nilsson, David

    2012-01-01

    In this study we illuminate and discuss the most recent developments in respect of the interpretation of the “industrial application” requirement with respect to gene and protein related inventions in Europe. The analysis will focus on the relevant provisions of the EPC and decisional practice from...... discussion, we will elaborate on two issues in particular; (i) determine which types of qualities an invention should have in order to meet the industrial application requirement in the first place; and (ii) what type of evidence an applicant is expected to present in respect of (potential) applications......-depth background, and maybe repetition for some readers, as to why the industrial application requirement raises particular concerns and questions in respect of biotech inventions....

  10. Capacity optimization and scheduling of a multiproduct manufacturing facility for biotech products.

    Science.gov (United States)

    Shaik, Munawar A; Dhakre, Ankita; Rathore, Anurag S; Patil, Nitin

    2014-01-01

    A general mathematical framework has been proposed in this work for scheduling of a multiproduct and multipurpose facility involving manufacturing of biotech products. The specific problem involves several batch operations occurring in multiple units involving fixed processing time, unlimited storage policy, transition times, shared units, and deterministic and fixed data in the given time horizon. The different batch operations are modeled using state-task network representation. Two different mathematical formulations are proposed based on discrete- and continuous-time representations leading to a mixed-integer linear programming model which is solved using General Algebraic Modeling System software. A case study based on a real facility is presented to illustrate the potential and applicability of the proposed models. The continuous-time model required less number of events and has a smaller problem size compared to the discrete-time model. © 2014 American Institute of Chemical Engineers.

  11. The Cambridge MRI database for animal models of Huntington disease.

    Science.gov (United States)

    Sawiak, Stephen J; Morton, A Jennifer

    2016-01-01

    We describe the Cambridge animal brain magnetic resonance imaging repository comprising 400 datasets to date from mouse models of Huntington disease. The data include raw images as well as segmented grey and white matter images with maps of cortical thickness. All images and phenotypic data for each subject are freely-available without restriction from (http://www.dspace.cam.ac.uk/handle/1810/243361/). Software and anatomical population templates optimised for animal brain analysis with MRI are also available from this site. Copyright © 2015. Published by Elsevier Inc.

  12. Cambridge IGCSE and international certificate French foreign language

    CERN Document Server

    Grime, Yvette; Thacker, Mike

    2013-01-01

    This brand-new Student Book provides a grammar-led approach with extensive exam preparation that will help you develop independent, culturally aware students of French ready for the exam. The book is written to the latest Cambridge International Examinations syllabus by experienced teachers. Extensive use of French reflects the style of the exams and, with specific advice and practice, it helps students use the acquired skills to their best ability. Topics on Francophone cultures are integrated throughout to ensure students gain the cultural awareness that is at the heart of this qualification

  13. Dynamics of center-periphery patterns in knowledge networks - the case of China's biotech science and technology system

    CERN Document Server

    Hennemann, Stefan; Liefner, Ingo

    2011-01-01

    Science and technology systems - and their epistemic communities - are usually hierarchical and composed of a number of strong, large, leading organizations, along with a number of smaller and less influential ones. Moreover, these hierarchical patterns have a spatial structure: the leading organizations are concentrated in a few places, creating a science and technology center, whereas the majority of locations are peripheral. In the example of biotech research in China, we found dynamic changes in center-periphery patterns. These results are based on a network analysis of evolving co-authorship networks from 2001 to 2009 that were built combining national and international databases. Therefore, our results are not only relevant for evaluating the spatial structure and dynamics in the Chinese biotech system and its integration into the global knowledge network, but also revive a discussion on persistence and processes of change in the systems theory for sciencebased industries.

  14. The Cambridge Structural Database in retrospect and prospect.

    Science.gov (United States)

    Groom, Colin R; Allen, Frank H

    2014-01-13

    The Cambridge Crystallographic Data Centre (CCDC) was established in 1965 to record numerical, chemical and bibliographic data relating to published organic and metal-organic crystal structures. The Cambridge Structural Database (CSD) now stores data for nearly 700,000 structures and is a comprehensive and fully retrospective historical archive of small-molecule crystallography. Nearly 40,000 new structures are added each year. As X-ray crystallography celebrates its centenary as a subject, and the CCDC approaches its own 50th year, this article traces the origins of the CCDC as a publicly funded organization and its onward development into a self-financing charitable institution. Principally, however, we describe the growth of the CSD and its extensive associated software system, and summarize its impact and value as a basis for research in structural chemistry, materials science and the life sciences, including drug discovery and drug development. Finally, the article considers the CCDC's funding model in relation to open access and open data paradigms. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Trait stacking for biotech crops: an essential consideration for agbiotech development projects for building trust

    Directory of Open Access Journals (Sweden)

    Ezezika Obidimma C

    2012-05-01

    Full Text Available Abstract The development of agricultural biotechnology humanitarian projects for food security in the last five years has been rapid in developing countries and is expected to rise sharply over the coming years. An extremely critical issue in these projects involves building trust with the community and farmers they aim to serve. For the first time, our social audit engagement with one of these initiatives, the Water Efficient Maize for Africa project, has revealed that a critical but unrecognized component of building trust with farmers involves publicly addressing the concerns surrounding stacked trait crops. As a result, we argue in this article that it is critical to actively anticipate the concerns that could be raised over trait stacking by incorporating them into global access plans of such initiatives early in order to facilitate adoption, provide the best value to the small-scale farmer and gain trust with the community whom these projects aim to serve. This perspective, based on an actual international social audit, should be of value to scientists, funders and partners involved in biotech development initiatives for food security.

  16. A history of plant biotechnology: from the Cell Theory of Schleiden and Schwann to biotech crops.

    Science.gov (United States)

    Vasil, Indra K

    2008-09-01

    Plant biotechnology is founded on the principles of cellular totipotency and genetic transformation, which can be traced back to the Cell Theory of Matthias Jakob Schleiden and Theodor Schwann, and the discovery of genetic transformation in bacteria by Frederick Griffith, respectively. On the 25th anniversary of the genetic transformation of plants, this review provides a historical account of the evolution of the theoretical concepts and experimental strategies that led to the production and commercialization of biotech (transformed or transgenic) plants expressing many useful genes, and emphasizes the beneficial effects of plant biotechnology on food security, human health, the environment, and conservation of biodiversity. In so doing, it celebrates and pays tribute to the contributions of scores of scientists who laid the foundation of modern plant biotechnology by their bold and unconventional thinking and experimentation. It highlights also the many important lessons to be learnt from the fascinating history of plant biotechnology, the significance of history in science teaching and research, and warns against the danger of the growing trends of ignoring history and historical illiteracy.

  17. The Cambridge Equation with government activity revisited A Equação de Cambridge com atividade governamental revisitada

    Directory of Open Access Journals (Sweden)

    Ricardo Silva Azevedo Araujo

    2010-12-01

    Full Text Available This paper offers an analysis of the steady-state distributional features found in a Kaldor-Pasinetti process, in which the government sector is allowed to run persistent deficits that may be financed through different instruments. Productive capital and bonds generate single rates of return, while workers' saving propensity remains uniform. This paper seeks to establish a generalization of Cambridge Eauqtion, considering the specific contributions of Steedman (1972, Pasinetti (1989, Dalziel (1991, and Faria (2000.Neste artigo faz-se uma análise das características distributivas do processo Kaldor-Pasinetti, assumindo-se que o setor governamental incorre em persistentes déficits que podem ser financiados através de diferentes instrumentos, como a emissão de títulos e de moeda. Através dessa abordagem é possível estudar como a atividade governamental afeta a distribuição de renda entre capitalistas e trabalhadores e assim obter generalizações do Teorema de Cambridge em que versões anteriores como as de Steedman (1972, Pasinetti (1989, Dalziel (1991 e Faria (2000 surgem como casos particulares.

  18. Traffic Sign Recognition System based on Cambridge Correlator Image Comparator

    Directory of Open Access Journals (Sweden)

    J. Turan

    2012-06-01

    Full Text Available Paper presents basic information about application of Optical Correlator (OC, specifically Cambridge Correlator, in system to recognize of traffic sign. Traffic Sign Recognition System consists of three main blocks, Preprocessing, Optical Correlator and Traffic Sign Identification. The Region of Interest (ROI is defined and chosen in preprocessing block and then goes to Optical Correlator, where is compared with database of Traffic Sign. Output of Optical Correlation is correlation plane, which consist of highly localized intensities, know as correlation peaks. The intensity of spots provides a measure of similarity and position of spots, how images (traffic signs are relatively aligned in the input scene. Several experiments have been done with proposed system and results and conclusion are discussed.

  19. 7th Cambridge Workshops on Universal Access and Assistive Technology

    CERN Document Server

    Lazar, J; Heylighen, A; Dong, H; Inclusive Designing : Joining Usability, Accessibility, and Inclusion

    2014-01-01

    ‘Inclusive Designing’ presents the proceedings of the seventh Cambridge Workshop on Universal Access and Assistive Technology (CWUAAT '14). It represents a unique multi-disciplinary workshop for the Inclusive Design Research community where designers, computer scientists, engineers, architects, ergonomists, policymakers and user communities can exchange ideas. The research presented at CWUAAT '14 develops methods, technologies, tools and guidance that support product designers and architects to design for the widest possible population for a given range of capabilities, within a contemporary social and economic context. In the context of developing demographic changes leading to greater numbers of older people and people with disabilities, the general field of Inclusive Design Research strives to relate the capabilities of the population to the design of products. Inclusive populations of older people contain a greater variation in sensory, cognitive and physical user capabilities. These variations may be...

  20. Next biotech plants: new traits, crops, developers and technologies for addressing global challenges.

    Science.gov (United States)

    Ricroch, Agnès E; Hénard-Damave, Marie-Cécile

    2016-08-01

    Most of the genetically modified (GM) plants currently commercialized encompass a handful of crop species (soybean, corn, cotton and canola) with agronomic characters (traits) directed against some biotic stresses (pest resistance, herbicide tolerance or both) and created by multinational companies. The same crops with agronomic traits already on the market today will continue to be commercialized, but there will be also a wider range of species with combined traits. The timeframe anticipated for market release of the next biotech plants will not only depend on science progress in research and development (R&D) in laboratories and fields, but also primarily on how demanding regulatory requirements are in countries where marketing approvals are pending. Regulatory constraints, including environmental and health impact assessments, have increased significantly in the past decades, delaying approvals and increasing their costs. This has sometimes discouraged public research entities and small and medium size plant breeding companies from using biotechnology and given preference to other technologies, not as stringently regulated. Nevertheless, R&D programs are flourishing in developing countries, boosted by the necessity to meet the global challenges that are food security of a booming world population while mitigating climate change impacts. Biotechnology is an instrument at the service of these imperatives and a wide variety of plants are currently tested for their high yield despite biotic and abiotic stresses. Many plants with higher water or nitrogen use efficiency, tolerant to cold, salinity or water submergence are being developed. Food security is not only a question of quantity but also of quality of agricultural and food products, to be available and accessible for the ones who need it the most. Many biotech plants (especially staple food) are therefore being developed with nutritional traits, such as biofortification in vitamins and metals. The main

  1. Geometry Report; Cambridge Conference on School Mathematics Feasibility Study No. 39.

    Science.gov (United States)

    Stolzenberg, Gabriel

    These materials were written with the aim of reflecting the thinking of the Cambridge Conference on School Mathematics (CCSM) regarding the goals and objectives for school mathematics. This report deals with some seventh grade mathematical concepts taught at Cambridge Friends' School. The discovery approach was utilized by the teacher in order to…

  2. A snuff, Sir? Et ego in Arcadia - op sabbatical in Cambridge

    NARCIS (Netherlands)

    Hondius, E.H.

    2005-01-01

    Een maand lang heb ik in Cambridge onderzoek mogen doen. In deze column wil ik daar verslag van uitbrengen. Niet van mijn onderzoek — ik heb vooral rondgekeken in de bibliotheek en gesproken met collega's om te zien wat momenteel in de common law te koop is - maar van Cambridge zelf.

  3. Anneli Randla kaitses doktorikraadi Cambridge'is / Anneli Randla ; interv. Reet Varblane

    Index Scriptorium Estoniae

    Randla, Anneli, 1970-

    1999-01-01

    5. mail kaitses Cambridge'is esimese eesti kunstiteadlasena doktorikraadi Anneli Randla. Töö teema: kerjusmungaordukloostrite arhitektuur Põhja-Euroopas. Juhendaja dr. Deborah Howard. Doktorikraadile esitatavatest nõudmistest, doktoritöö kaitsmisest, magistrikraadi kaitsnu õppimisvõimalustest Cambridge's.

  4. Success in the US: Are Cambridge International Assessments Good Preparation for University Study?

    Science.gov (United States)

    Shaw, Stuart; Bailey, Clare

    2011-01-01

    This article focuses on the research being conducted by University of Cambridge International Examinations (Cambridge) to ensure that its international assessments prepare students as well as Advanced Placement and International Baccalaureate for continued studies in colleges and universities. The primary purpose of the research is to highlight…

  5. Assessing the Impact of Arts and Humanities Research at the University of Cambridge. Technical Report

    Science.gov (United States)

    Levitt, Ruth; Celia, Claire; Diepeveen, Stephanie; Chonaill, Siobhan Ni; Rabinovich, Lila; Tiessen, Jan

    2010-01-01

    This project for the University of Cambridge and the Arts and Humanities Research Council (AHRC) assesses the impacts of arts and humanities research at the University of Cambridge. Evidence from interviews, a survey of research staff and detailed case studies indicates that these disciplines already have a broad range of impacts. Many of these…

  6. Investigating the Impact of Cambridge International Assessments on U.S. Stakeholders: Student and Teacher Perceptions

    Science.gov (United States)

    Shaw, Stuart

    2011-01-01

    As part of the continuing program to study the impact of its international assessments, the University of Cambridge International Examinations ("Cambridge") has undertaken a series of studies investigating the impact on a range of US stakeholders. This paper reports on research designed to respond to a series of washback and impact…

  7. Insect-resistant biotech crops and their impacts on beneficial arthropods

    Science.gov (United States)

    Gatehouse, A. M. R.; Ferry, N.; Edwards, M. G.; Bell, H. A.

    2011-01-01

    With a projected population of 10 billion by 2050, an immediate priority for agriculture is to achieve increased crop yields in a sustainable and cost-effective way. The concept of using a transgenic approach was realized in the mid-1990s with the commercial introduction of genetically modified (GM) crops. By 2010, the global value of the seed alone was US $11.2 billion, with commercial biotech maize, soya bean grain and cotton valued at approximately US $150 billion. In recent years, it has become evident that insect-resistant crops expressing δ-endotoxin genes from Bacillus thuringiensis have made a significant beneficial impact on global agriculture, not least in terms of pest reduction and improved quality. However, because of the potential for pest populations to evolve resistance, and owing to lack of effective control of homopteran pests, alternative strategies are being developed. Some of these are based on Bacillus spp. or other insect pathogens, while others are based on the use of plant- and animal-derived genes. However, if such approaches are to play a useful role in crop protection, it is desirable that they do not have a negative impact on beneficial organisms at higher trophic levels thus affecting the functioning of the agro-ecosystem. This widely held concern over the ecological impacts of GM crops has led to the extensive examination of the potential effects of a range of transgene proteins on non-target and beneficial insects. The findings to date with respect to both commercial and experimental GM crops expressing anti-insect genes are discussed here, with particular emphasis on insect predators and parasitoids. PMID:21444317

  8. Psychometric properties of the Cambridge depersonalization scale in Puerto Rico.

    Science.gov (United States)

    Aponte-Soto, Michell R; Vélez-Pastrana, María; Martínez-Taboas, Alfonso; González, Rafael A

    2014-01-01

    Depersonalization experiences have been studied in the United States and Europe, but there is a dearth of investigations with Latino populations. In the current study we examined the psychometric properties of the Spanish version of the Cambridge Depersonalization Scale (CDS) in 300 adult individuals from the community and compared the results with those reported previously with non-Latino clinical populations. Discrepant findings have been reported with respect to the factor structure of the CDS. We performed exploratory and confirmatory factor analyses on the CDS items and compared our results with published analyses on other populations. Results revealed that the psychometric properties of the CDS, such as reliability, seem adequate, although the factor structure of the CDS seems to be inconsistent across studies. We selected a 4-factor solution that was most parsimonious and best fit our data. Furthermore, we obtained a moderate, statistically significant relationship (r = .64, p = .001) between the CDS and the Dissociative Experiences Scale. Our results, utilizing a nonclinical sample of Puerto Rican adults, suggest that depersonalization experiences can be reliably measured in a Latino and Spanish-speaking population.

  9. Who Needs a Revision? 20 Years of Cambridge Shunt Lab.

    Science.gov (United States)

    Czosnyka, Zofia; Czosnyka, Marek; Pickard, John D; Chari, Aswin

    2016-01-01

    Shunt testing independent of manufacturers provides knowledge that can significantly improve the management of patients with hydrocephalus. The Cambridge Shunt Evaluation Laboratory was created 20 years ago. Thanks to financial support from the Department of Health (1993-1998), all shunts in use in the UK were systematically evaluated, with "blue reports" being published. Later new devices were tested as they appeared in public domain.Twenty-six models have been evaluated. The majority of the valves had a non-physiologically low hydrodynamic resistance that may result in over-drainage, both related to posture and during nocturnal cerebral vasogenic waves. A long distal catheter increases the resistance of these valves by 100-200 %. Drainage through valves without a siphon-preventing mechanism is very sensitive to body posture. Shunts with siphon-preventing accessories offer a reasonable resistance to negative outlet pressure. Bench parameters were used to test shunt performance in vivo using infusion tests. A criterion for correctly performing a shunt procedure was established. Pressure measured in the shunt prechamber during the plateau phase of infusion should not remain more than 5 mmHg above the le shunt's operating pressure plus hydrodynamic resistance of the valve multiplied by the infusion rate. "Critical levels" for every shunt and every performance level have been used in the shunt testing wizard of ICM+ software.

  10. Findings from the Harvard Medical School Cambridge Integrated Clerkship, a Year-Long Longitudinal Psychiatry Experience.

    Science.gov (United States)

    Cheng, Elisa; Hirsh, David; Gaufberg, Elizabeth; Griswold, Todd; Wesley Boyd, J

    2017-06-23

    The Harvard Medical School Cambridge Integrated Clerkship is a longitudinal integrated clerkship that has provided an alternative clinical model for medical education in psychiatry since its inception in 2004. This study was undertaken in an effort to better understand the student experience of the Cambridge Integrated Clerkship and how it may have impacted students' perceptions of and interest in psychiatry, as well as performance. Qualitative surveys were sent via e-mail to the first 11 student cohorts who had completed the Cambridge Integrated Clerkship (from 2004 to 2014) and for whom we had e-mail addresses (N = 100), and the free-text responses were coded thematically. All available standardized scoring data and residency match data for Cambridge Integrated Clerkship graduates were obtained. From 2006 to 2014, 12 out of 73 Cambridge Integrated Clerkship students who entered the match chose a psychiatry residency (16.4%), four times more than students in traditional clerkships at Harvard Medical School (3.8% of 1355 students) or the national average (4.1% of 146,066 US applicants). Thirty of the 100 surveyed Cambridge Integrated Clerkship graduates (30%) responded to the qualitative survey with free-text remarks on a number of themes. Cambridge Integrated Clerkship students compared positively to their classmates in terms of standardized test performance. Their fourfold higher match rate into psychiatry compared to other students raises intriguing questions as to what role a longitudinal clerkship might have played in developing interest in psychiatry as a career.

  11. Plastination in Anatomy Learning: An Experience at Cambridge University.

    Science.gov (United States)

    Latorre, Rafael; Bainbridge, David; Tavernor, Angie; López Albors, Octavio

    Due to lack of objective data, the benefits of using plastination in combination with wet dissection in teaching gross anatomy are unknown. The aim of this study was to obtain objective evidence from students regarding the effectiveness of combining plastinated specimens (PS) with an established gross anatomy education program at Cambridge University that uses wet cadaver dissection and small-group tutorials. For a complete academic year, a total of 135 PS were used alongside wet cadaver dissections. The PS were also available for small-group tutorials. An anonymous closed questionnaire, using a 5-point numerical-estimation Likert scale, was used to gather information relating to the effectiveness of the PS. The level of student satisfaction with the combined use of wet dissections and PS was high, although higher (p<.05) for second-year students (98.4%) than for first-year students (95.5%). Students felt the specimens allowed them to see details that were often more difficult to identify in their dissections, for instance nerves. Voluntary use of PS was higher (p<.01) for second-year students (96.9%), who had previously experienced anatomy teaching with cadaver dissection alone, than for first-year students (77.7%). Overall, 97.7% of all students thought that the PS helped them understand and learn anatomy. All students surveyed (100%) recommended the use of PS in the future. Students considered the use of PS in the dissection room combined with wet cadaver dissection to be beneficial when learning anatomy, particularly when combined with their use during small-group tutorials.

  12. Cambridge Polytrauma Pathway: Are we making appropriately guided decisions?

    Science.gov (United States)

    Wynell-Mayow, William; Guevel, Borna; Quansah, Benjamin; O'Leary, Ronan; Carrothers, Andrew D

    2016-10-01

    Addenbrooke's Hospital, the Major Trauma Centre for the East of England Trauma Network, received 1070 major trauma patients between 1st January and 31st December 2014. In order to improve care, an audit was performed of 59 patients meeting our own selection criteria for orthopaedic polytrauma between 1st January 2013 and 31st December 2013. The Cambridge Polytrauma Pathway was devised through NCEPOD guidelines, literature review, internal and external discussion. It facilitates provision of best practice Early Appropriate Care, encompassing - multidisciplinary consultant decisions around the patient in our Neurological and Trauma Critical Care Unit, early full body trauma CT scans, serial measurements of lactate and fibrinogen levels, and out-of-hours orthopaedic theatre reserved for life-and-limb threatening injuries. Re-audit was conducted of 15 patients meeting selection criteria, admitted between 1st October 2014 and 31st March 2015. Significant improvements in recording of lactate and fibrinogen were demonstrated, both on admission (lactate - p<0.000, fibrinogen - p=0.015), and preoperatively (lactate - p=0.003, fibrinogen - p=0.030). Time to trauma CT was unchanged (p=0.536) with a median time to CT of 0.53h at re-audit (IQR 0.48-0.75). The number of patients receiving definitive orthopaedic intervention out-of-hours reduced from 8 to zero (p=0.195). The approach of facilitating management decisions to be made at early daytime MDT meetings has been adopted. It is anticipated that this pathway will improve outcomes in orthopaedic polytrauma patients and it is recommended that either the GOS-E, or the EQ-5D scoring systems be introduced to assess this. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  13. Rapid Near Infra-red Reflectance Analysis (NIRA) of Mainstream Smoke Collected on Cambridge Filter Pads

    National Research Council Canada - National Science Library

    C DiLuzio; S Morzilli; E Cardinale

    Near infra-red (NIR) reflectance spectroscopy has been used for rapidly and reproducibly measuring the NIR spectra of mainstream smoke collected on Cambridge filter pads and quantifying the chemical composition from the spectral data...

  14. Cambridge Safer Truck Initiative : Vehicle-Based Strategies to Protect Pedestrians and Bicyclists

    Science.gov (United States)

    2016-03-01

    This report summarizes Volpe, The National Transportation Systems Centers (Volpes) research and recommendations for the City of Cambridge for implementing a number of proven vehicle safety strategies, including truck side guards, blind spot mir...

  15. Oxford and Cambridge Boat Race: Performance, Pacing and Tactics Between 1890 and 2014

    OpenAIRE

    Edwards, Andrew M.; Guy, Joshua H.; Hettinga, Florentina J.

    2016-01-01

    Background: Currently no studies have examined the historical performances of Oxford and Cambridge Boat Race crews in the context of performance, pacing and tactics which is surprising as the event has routinely taken place annually for over 150 years on the same course. \\ud \\ud Objectives: The purpose of this study was twofold, to firstly examine the historical development of performances and physical characteristics of crews over 124 years of the Oxford and Cambridge Boat Race between 1890 ...

  16. The present status of commercialized and developed biotech (GM) crops, results of evaluation of plum 'HoneySweet" for resistance to plum pox virus in the Czech Republic

    Science.gov (United States)

    Commercialization of biotech (GM) crops started in 1996. A significant increase of 9 million hectars was realized in 1996-2009. In the years 2010-2011, it was already 12 million hectars (8 percent of total crop area). 16.7 million farmers in 29 countries planted 160 million hectars of GM crops in...

  17. Explaining ICT Infrastructure and E-Commerce Uses and Benefits in Industrial Clusters-Evidence from a Biotech Cluster

    DEFF Research Database (Denmark)

    Scupola, Ada; Steinfield, Charles

    2006-01-01

    The literature on Industrial Clusters has not focused heavely on the role of the ICT infrastructure, nor on the potentail implications of electronic commerce. In this paper, we examine the theoretical bases for bringing these research streams together, and develop expectations for how firms...... in an industrial cluster might utilize and derive benefit from a public, broadband ICT infrastructure, particularly in support of e-commerce applications. A case study of a successful biotech cluster in Denamrk and Sweden-The Medicon Valley-provides a preliminary test of these expectations. Distinctions in uses...... and benefits based upon firm size are considered. A key finding is that small firms that would not otherwise be expected to gain from global e-commerce can rely on the cluster "brand" to enable trade with unknown and distant partners....

  18. A Robust Method of Measuring Other-Race and Other-Ethnicity Effects: The Cambridge Face Memory Test Format

    OpenAIRE

    McKone, Elinor; Stokes, Sacha; Liu, Jia; Cohan, Sarah; Fiorentini, Chiara; Pidcock, Madeleine; Yovel, Galit; Broughton, Mary; Pelleg, Michel

    2012-01-01

    Other-race and other-ethnicity effects on face memory have remained a topic of consistent research interest over several decades, across fields including face perception, social psychology, and forensic psychology (eyewitness testimony). Here we demonstrate that the Cambridge Face Memory Test format provides a robust method for measuring these effects. Testing the Cambridge Face Memory Test original version (CFMT-original; European-ancestry faces from Boston USA) and a new Cambridge Face Memo...

  19. Taxonomic review of the New World spider genus Elaver O. Pickard-Cambridge, 1898 (Araneae, Clubionidae).

    Science.gov (United States)

    Saturnino, Regiane; Bonaldo, Alexandre Bragio

    2015-11-23

    Elaver O. Pickard-Cambridge, 1898 is characterized and redescribed, including 49 species occurring from the United States to Argentina. Thirty seven previously known species are redescribed: Elaver achuca (Roddy, 1966) revalidated, E. balboae (Chickering, 1937), E. barroana (Chickering, 1937), E. calcarata (Kraus, 1955), E. carlota (Bryant, 1940), E. chisosa (Roddy, 1966), E. crinophora (Franganillo, 1934), E. crocota (O. Pickard-Cambridge, 1896), E. albicans (Franganillo, 1930) name restored, E. depuncta O. Pickard-Cambridge, 1898, E. elaver (Bryant, 1940), E. excepta (L. Koch, 1866), E. grandivulva (Mello-Leitão, 1930), E. hortoni (Chickering, 1937), E. implicata (Gertsch, 1941), E. juana (Bryant, 1940), E. kohlsi (Gertsch & Jellison, 1939), E. linguata (F.O. Pickard-Cambridge, 1900), E. madera (Roddy, 1966), E. mirabilis (O. Pickard-Cambridge, 1896) new. comb., E. mulaiki (Gertsch, 1935), E. multinotata (Chickering, 1937), E. orvillei (Chickering, 1937), E. placida O. Pickard-Cambridge, 1898, E. portoricensis (Petrunkevitch, 1930), E. quadrata (Kraus, 1955), E. richardi (Gertsch, 1941), E. sericea O. Pickard-Cambridge, 1898, E. sigillata (Petrunkevitch, 1925), E. simplex (O. Pickard-Cambridge, 1896), E. texana (Gertsch, 1933), E. tigrina O. Pickard-Cambridge, 1898 name restored, E. tricuspis (F.O. Pickard-Cambridge, 1900), E. tristani (Banks, 1909), E. tumivulva (Banks, 1909), E. valvula (F.O. Pickard-Cambridge, 1900) and E. wheeleri (Roewer, 1933). Ten new species are described: E. candelaria n. sp. and E. helenae n. sp. from Mexico; E. arawakan n. sp. from Haiti; E. lizae n. sp. from Costa Rica; E. darwichi n. sp. from Ecuador; E. juruti n. sp., E. tourinhoae n. sp. and E. vieirae n. sp. from Brazil; E. shinguito n. sp. from Peru and E. beni n. sp. from Bolivia. The female of E. hortoni is described for the first time. Lectotypes are designated for E. sigillata and its actual female is described for the first time. Four new synonyms are proposed: E. languida

  20. Brief history of the Cambridge STEM aberration correction project and its progeny

    Energy Technology Data Exchange (ETDEWEB)

    Brown, L. Michael [Cavendish Laboratory, University of Cambridge, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Batson, Philip E. [Institute for Advanced Materials, Devices and Nanotechnology, Rutgers University, Piscataway, NJ 08854 (United States); Department of Physics, Rutgers University, Piscataway, NJ 08854 (United States); Department of Materials Science, Rutgers University, Piscataway, NJ 08854 (United States); Dellby, Niklas [Nion Company, 11515 NE 118th Street, Kirkland, WA 98034 (United States); Krivanek, Ondrej L. [Nion Company, 11515 NE 118th Street, Kirkland, WA 98034 (United States); Department of Physics, Arizona State University, Tempe, AZ 85287 (United States)

    2015-10-15

    We provide a brief history of the project to correct the spherical aberration of the scanning transmission electron microscope (STEM) that started in Cambridge (UK) and continued in Kirkland (WA, USA), Yorktown Heights (NY, USA), and other places. We describe the project in the full context of other aberration correction research and related work, partly in response to the incomplete context presented in the paper “In quest of perfection in electron optics: A biographical sketch of Harald Rose on the occasion of his 80th birthday”, recently published in Ultramicroscopy. - Highlights: • We provide a brief history of the Cambridge project to correct the spherical aberration of the scanning transmission electron microscope (STEM). • We describe the project in the full context of other aberration correction work and related research. • We summarize our corrector development work that followed the Cambridge project, and which was the first to reach higher spatial resolution than any non-corrected electron microscope.

  1. Water quality in the Cambridge, Massachusetts, drinking-water source area, 2005-8

    Science.gov (United States)

    Smith, Kirk P.; Waldron, Marcus C.

    2015-01-01

    During 2005-8, the U.S. Geological Survey, in cooperation with the Cambridge, Massachusetts, Water Department, measured concentrations of sodium and chloride, plant nutrients, commonly used pesticides, and caffeine in base-flow and stormwater samples collected from 11 tributaries in the Cambridge drinking-water source area. These data were used to characterize current water-quality conditions, to establish a baseline for future comparisons, and to describe trends in surface-water quality. The data also were used to assess the effects of watershed characteristics on surface-water quality and to inform future watershed management.

  2. Accumulation and Circulation of the Knowledge Needed for Biotech Business Promotion by Engineers of R&D Section in an IT Enterprise: The Case of Hitachi Software Engineering Co., Ltd

    Directory of Open Access Journals (Sweden)

    Hirofumi Ota

    2012-01-01

    Full Text Available Much research has been carried out on the accumulation and effective use of knowledge as a company-specific form of intellectual property. However, insufficient attention has been given to research focusing on the effects of micro-level knowledge absorption and its effective use. In this paper, we try to demonstrate what should be done in order to promote new biotech business from the perspective of each engineer’s knowledge, through a micro-level investigation focusing on the life science business section of one IT enterprise. Based on the results of a questionnaire survey of engineers, interviews of several engineers, and patent data analysis, we discuss the progress of the biotech business in an IT enterprise from the aspect of accumulation and circulation of knowledge in a core technology field, the IT business, and a technology field of new entry, the biotech business. This paper reports that the positive growth cycle of biotech business promotion in an IT enterprise, using Hitachi Software Engineering Co., Ltd. as a case, attained by incorporating the latest biotech knowledge from junior engineers and utilizing IT knowledge from middle engineers leads to the recruiting of qualified students.Keywords: accumulation and circulation of the knowledge, biotech business, open innovation, patent data analysis, questionnaire survey

  3. Linguistic Turn and Gendering Language in the Cambridge Advanced Learner's Dictionary

    Science.gov (United States)

    Arimbi, Diah A.; Kwary, Deny A.

    2016-01-01

    Language constructs how humans perceive things. Since language is a human construction, it tends to be biased as it is mainly men's construction. Using gender perspectives, this paper attempts to discuss the imbalance in gender representations found in the examples given in an English learner's dictionary, that is, the "Cambridge Advanced…

  4. Technology Acquisition and Knowledge Networks : Knoweldge Economy Forum VI, Cambridge, United Kingdom

    OpenAIRE

    World Bank

    2007-01-01

    The paper is a report to cover the proceedings of the Knowledge Economy Forum VI held in Cambridge, UK in 2007. This report encapsulates the end product of the conference with regard to the current state of the European knowledge economy, especially in Eastern Europe.

  5. The Singapore-Cambridge General Certificate of Education Advanced-Level General Paper Examination

    Science.gov (United States)

    Hassan, Nurul Huda; Shih, Chih-Min

    2013-01-01

    This article describes and reviews the Singapore-Cambridge General Certificate of Education Advanced Level General Paper (GP) examination. As a written test that is administered to preuniversity students, the GP examination is internationally recognised and accepted by universities and employers as proof of English competence. In this article, the…

  6. The Target of the Question: A Taxonomy of Textual Features for Cambridge University "O" Levels English

    Science.gov (United States)

    Benjamin, Shanti Isabelle

    2015-01-01

    This study investigates the typical textual features that are most frequently targeted in short-answer reading comprehension questions of the Cambridge University "O" Level English Paper 2. Test writers' awareness of how textual features impact on understanding of meanings in text decisions will determine to great extent their decisions…

  7. Up the Garden Path: A Chemical Trail through the Cambridge University Botanic Garden

    Science.gov (United States)

    Battle, Gary M.; Kyd, Gwenda O.; Groom, Colin R.; Allen, Frank H.; Day, Juliet; Upson, Timothy

    2012-01-01

    The living world is a rich source of chemicals with many medicines, dyes, flavorings, and foodstuffs having their origins in compounds produced by plants. We describe a chemical trail through the plant holdings of the Cambridge University Botanic Gardens. Visitors to the gardens are provided with a laminated trail guide with 22 stopping points…

  8. Measuring Impairments in Memory and Executive Function in Older People Using the Revised Cambridge Cognitive Examination

    NARCIS (Netherlands)

    Kessels, R.P.C.; Mimpen, G.; Melis, R.J.F.; Olde Rikkert, M.G.M.

    2009-01-01

    Objectives: The Revised Cambridge Cognitive Examination (CAMCOG-R) is a cognitive screen that has been used to discriminate individuals with dementia from cognitively intact older people. It consists of items assessing various cognitive domains, but the construct validity of the cognitive subscores

  9. Measuring impairments in memory and executive function in older people using the Revised Cambridge Cognitive Examination.

    NARCIS (Netherlands)

    Kessels, R.P.C.; Mimpen, G.; Melis, R.J.F.; Olde Rikkert, M.G.M.

    2009-01-01

    OBJECTIVES: The Revised Cambridge Cognitive Examination (CAMCOG-R) is a cognitive screen that has been used to discriminate individuals with dementia from cognitively intact older people. It consists of items assessing various cognitive domains, but the construct validity of the cognitive subscores

  10. Ideology, Class and Rationality: A Critique of Cambridge International Examinations' "Thinking Skills" Curriculum

    Science.gov (United States)

    Lim, Leonel

    2012-01-01

    This article undertakes a critique of the aims and objectives of "Thinking Skills", one of the most widely and internationally used curricula in the teaching of thinking, offered by the University of Cambridge International Examinations. By engaging in a critical discourse analysis of how political and class biases are (re-)produced in the forms…

  11. What To Look for in ESL Admission Tests: Cambridge Certificate Exams, IELTS, and TOEFL.

    Science.gov (United States)

    Chalhoub-Deville, Micheline; Turner, Carolyn E.

    2000-01-01

    Familiarizes test users with issues to consider when employing assessments for screening and admission purposes. Examines the purpose, content, and scoring methods of three English-as-a-Second-Language admissions tests--the Cambridge certificate exams, International English Language Teaching System, and Test of English as a Foreign…

  12. A Comparison of the Abilities Measured by the Cambridge and Educational Testing Service EFL Test Batteries.

    Science.gov (United States)

    Bachman, Lyle F.; And Others

    1990-01-01

    The abilities measured by the First Certificate of English (FCE) administered by the Cambridge Local Examinations Syndicate are compared with the Test of English as a Foreign Language (TOEFL) administered by the Educational Testing Service. The analyses suggest that the FCE and TOEFL appear to measure the same common aspect of language…

  13. Curriculum, Pedagogy, and the Cambridge Primary Review: A Response to R. J. Campbell

    Science.gov (United States)

    Armstrong, Michael

    2011-01-01

    This article presents the author's response to R.J. Campbell's critique of the "Cambridge Primary Review," which was published in the autumn of 2009. The author argues that Campbell's description of the "Review's" central proposals on curriculum and pedagogy as "backward-looking and inadequately theorised" is so misjudged as to call for a…

  14. Psychiatry in the Harvard Medical School-Cambridge Integrated Clerkship: An Innovative, Year-Long Program

    Science.gov (United States)

    Griswold, Todd; Bullock, Christopher; Gaufberg, Elizabeth; Albanese, Mark; Bonilla, Pedro; Dvorak, Ramona; Epelbaum, Claudia; Givon, Lior; Kueppenbender, Karsten; Joseph, Robert; Boyd, J. Wesley; Shtasel, Derri

    2012-01-01

    Objective: The authors present what is to their knowledge the first description of a model for longitudinal third-year medical student psychiatry education. Method: A longitudinal, integrated psychiatric curriculum was developed, implemented, and sustained within the Harvard Medical School-Cambridge Integrated Clerkship. Curriculum elements…

  15. Mime, Music and Drama on the Eighteenth-Century Stage. The Ballet d'Action. Edward Nye, Cambridge-New York, Cambridge University Press, 2011

    Directory of Open Access Journals (Sweden)

    Stefania Onesti

    2012-11-01

    Full Text Available Mime, Music and Drama on the Eighteenth-Century Stage by Edward Nye (Cambridge University Press, 2011 has the merit of inspiring a strong reflection on ballet d'action, connected with cultural, literaturary and philosophic environment of Eighteenth century. The author, with brilliant insight and careful historical research, explores the most debated issues of the new genre, providing an unusual interpretation. The review traces the focal points and the structure of the book, developing further consideration of some of the most challenging aspects offered by the text.

  16. The Cambridge Car Memory Test: a task matched in format to the Cambridge Face Memory Test, with norms, reliability, sex differences, dissociations from face memory, and expertise effects.

    Science.gov (United States)

    Dennett, Hugh W; McKone, Elinor; Tavashmi, Raka; Hall, Ashleigh; Pidcock, Madeleine; Edwards, Mark; Duchaine, Bradley

    2012-06-01

    Many research questions require a within-class object recognition task matched for general cognitive requirements with a face recognition task. If the object task also has high internal reliability, it can improve accuracy and power in group analyses (e.g., mean inversion effects for faces vs. objects), individual-difference studies (e.g., correlations between certain perceptual abilities and face/object recognition), and case studies in neuropsychology (e.g., whether a prosopagnosic shows a face-specific or object-general deficit). Here, we present such a task. Our Cambridge Car Memory Test (CCMT) was matched in format to the established Cambridge Face Memory Test, requiring recognition of exemplars across view and lighting change. We tested 153 young adults (93 female). Results showed high reliability (Cronbach's alpha = .84) and a range of scores suitable both for normal-range individual-difference studies and, potentially, for diagnosis of impairment. The mean for males was much higher than the mean for females. We demonstrate independence between face memory and car memory (dissociation based on sex, plus a modest correlation between the two), including where participants have high relative expertise with cars. We also show that expertise with real car makes and models of the era used in the test significantly predicts CCMT performance. Surprisingly, however, regression analyses imply that there is an effect of sex per se on the CCMT that is not attributable to a stereotypical male advantage in car expertise.

  17. An overview of the pterosaur assemblage from the Cambridge Greensand (Cretaceous of Eastern England

    Directory of Open Access Journals (Sweden)

    D. M. Unwin

    2001-01-01

    Full Text Available The Cambridge Greensand, a remanié deposit that crops out in Cambridgeshire, eastern England, has yielded numerous, though fragmentary, late Early Cretaceous (Albian vertebrate fossils including more than 2000 isolated pterosaur bones. So far, 32 species of pterosaur have been proposed in connection with the Cambridge Greensand material, but there has been and continues to be considerable confusion concerning the validity of these taxa, their relationships to each other and to other pterosaurs, and the material upon which they were established. A comprehensive systematic revision identified eleven valid species distributed among three families: the Ornithocheiridae (Ornithocheirus simus and possibly a second, as yet unnamed species of Ornithocheirus, Coloborhynchus capito, Coloborhynchus sedgwickii, Anhanguera cuvieri, and Anhanguera fittoni; the Lonchodectidae (Lonchodectes compressirostris, Lonchodectes machaerorhynchus, Lonchodectes microdon and Lonchodectes platystomus; and a species of edentulous pterosaur (Ornithostoma sedgwicki that may represent the earliest record for the Pteranodontidae. It is possible that some of the taxa currently recognised represent sexual dimorphs (Coloborhynchus capito and Coloborhynchus sedgwickii, Lonchodectes compressirostris and Lonchodectes machaerorhynchus, or disjunct populations of a single species (Ornithocheirus simus and Ornithocheirus sp., Lonchodectes compressirostris and Lonchodectes microdon and that there may be as few as seven valid species, but the Cambridge Greensand pterosaurs are too poorly known to demonstrate this at present. The Cambridge Greensand pterosaur assemblage is similar to a slightly younger, but much smaller assemblage from the Lower Chalk of England and shares some elements, such as ornithocheirids, in common with many other late Early and early Late Cretaceous assemblages. It is distinguished by the absence of tapejarids and the presence of Lonchodectes which, so far, is

  18. In search of low cost titanium: the fray farthing chen (FFC) cambridge process

    CSIR Research Space (South Africa)

    Oosthuizen, SJ

    2011-03-01

    Full Text Available . Topics explored include the history of the process, attempts at commercial- ization, NASA?s alternative application, and present status of the process. Keywords FFC Cambridge, titanium, molten salt. * Materials Science and Manufacturing, CSIR.... Oxygen production for rocket propulsion promises by far the greatest cost and mass saving of any off-world in situ resource utilization (ISRU). Since the 1960s most work on lunar resource utilization focused on the mineral ilmenite (FeTiO3...

  19. PET/MRI in the infarcted mouse heart with the Cambridge split magnet

    Science.gov (United States)

    Buonincontri, Guido; Sawiak, Stephen J.; Methner, Carmen; Krieg, Thomas; Hawkes, Robert C.; Adrian Carpenter, T.

    2013-02-01

    Chronic heart failure, as a result of acute myocardial infarction, is a leading cause of death worldwide. Combining diagnostic imaging modalities may aid the direct assessment of experimental treatments targeting heart failure in vivo. Here we present preliminary data using the Cambridge combined PET/MRI imaging system in a mouse model of acute myocardial infarction. The split-magnet design can deliver uncompromised MRI and PET performance, for better assessment of disease and treatment in a preclinical environment.

  20. In search of low cost titanium: the Fray Farthing Chen (FFC) Cambridge process

    CSIR Research Space (South Africa)

    Oosthuizen, SJ

    2010-10-01

    Full Text Available of aggressive/reactive chemicals to deliver “titanium sponge”, which requires capital and labor intensive product recovery, handling and processing. The batches of titanium sponge are produced over several days in steel vessels, delivering around 10 tons... in technology transfer, innovation management and investment rounds from seed to IPO. 2002 – 2003 COMMERCIAL DIRECTOR, HEAD PORTER, CAMBRIDGE, UK • Head Porter is a wireless technology start-up company founded by four students at the University...

  1. PET/MRI in the infarcted mouse heart with the Cambridge split magnet

    Energy Technology Data Exchange (ETDEWEB)

    Buonincontri, Guido, E-mail: gb396@cam.ac.uk [Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke' s Hospital, Hills Road, Cambridge, CB2 0QQ (United Kingdom); Sawiak, Stephen J. [Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke' s Hospital, Hills Road, Cambridge, CB2 0QQ (United Kingdom); Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge (United Kingdom); Methner, Carmen; Krieg, Thomas [Department of Medicine, University of Cambridge, Cambridge (United Kingdom); Hawkes, Robert C.; Adrian Carpenter, T. [Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke' s Hospital, Hills Road, Cambridge, CB2 0QQ (United Kingdom)

    2013-02-21

    Chronic heart failure, as a result of acute myocardial infarction, is a leading cause of death worldwide. Combining diagnostic imaging modalities may aid the direct assessment of experimental treatments targeting heart failure in vivo. Here we present preliminary data using the Cambridge combined PET/MRI imaging system in a mouse model of acute myocardial infarction. The split-magnet design can deliver uncompromised MRI and PET performance, for better assessment of disease and treatment in a preclinical environment.

  2. Nutrition in medical education: reflections from an initiative at the University of Cambridge.

    Science.gov (United States)

    Ball, Lauren; Crowley, Jennifer; Laur, Celia; Rajput-Ray, Minha; Gillam, Stephen; Ray, Sumantra

    2014-01-01

    Landmark reports have confirmed that it is within the core responsibilities of doctors to address nutrition in patient care. There are ongoing concerns that doctors receive insufficient nutrition education during medical training. This paper provides an overview of a medical nutrition education initiative at the University of Cambridge, School of Clinical Medicine, including 1) the approach to medical nutrition education, 2) evaluation of the medical nutrition education initiative, and 3) areas identified for future improvement. The initiative utilizes a vertical, spiral approach during the clinically focused years of the Cambridge undergraduate and graduate medical degrees. It is facilitated by the Nutrition Education Review Group, a group associated with the UK Need for Nutrition Education/Innovation Programme, and informed by the experiences of their previous nutrition education interventions. Three factors were identified as contributing to the success of the nutrition education initiative including the leadership and advocacy skills of the nutrition academic team, the variety of teaching modes, and the multidisciplinary approach to teaching. Opportunities for continuing improvement to the medical nutrition education initiative included a review of evaluation tools, inclusion of nutrition in assessment items, and further alignment of the Cambridge curriculum with the recommended UK medical nutrition education curriculum. This paper is intended to inform other institutions in ongoing efforts in medical nutrition education.

  3. What affects the innovation performance of small and medium-sized enterprises (SMEs) in the biotechnology industry? An empirical study on Korean biotech SMEs.

    Science.gov (United States)

    Kang, Kyung-Nam; Lee, Yoon-Sik

    2008-10-01

    Research-intensive small and medium-sized enterprises (SMEs) play a crucial role in the advancement of the biotechnology industry. This paper explored the impacts of internal and contextual variables on innovative activity in Korea and compared the results of this analysis with previous studies of other countries. Our analysis of 149 Korean biotech SMEs showed that the ratio of R&D expenditure to sales, the ratio of R&D employees to total employees, CEO characteristics, governmental support and international networking are positively correlated with a firm's innovation performance. The results may help decision makers to better foster SMEs in the Korean biotechnology industry.

  4. Public administration and R&D localisation by pharmaceutical and biotech companies: a theoretical framework and the Italian case-study.

    Science.gov (United States)

    Jommi, Claudio; Paruzzolo, Silvia

    2007-04-01

    This article has two objectives. It firstly provides a general framework for variables that influence R&D (Research and Development) localisation by pharmaceutical and biotech companies. The analysis of R&D localization includes both in-house R&D and contracted R&D. Following a systematic literature search, these variables were classified into four distinct categories: regulatory environment, institutional framework, national systems of innovation and local development and specialisation. The authors highlight that some of these factors directly depend on the action of public administrations (e.g., patent protection, price regulation, public investments in research, and incentives to private companies); others are indirectly influenced by public policies (e.g., GDP growth rate, infrastructures). This theoretical framework was used to analyse the Italian case-study. Pros and cons of the Italian context were investigated from the point of view of multinational pharmaceutical companies and the Italian Association of Biotech Companies. Interviews were chosen as the most appropriate data gathering technique given the exploratory nature of the study of the Italian context. The paper is divided into five parts. A brief introduction provides figures showing that Europe has been loosing positions compared with other Continents and the same has occurred in Italy compared with other EU countries. The second one illustrates the methodology. The third one is focused on variables affecting R&D localisation. In the fourth section the Italian case-study is discussed. Theoretical and empirical findings are summarised and discussed in the conclusions.

  5. Plant Biotech Lab Manual.

    Science.gov (United States)

    Tant, Carl

    This book provides laboratory experiments to enhance any food science/botany curriculum. Chapter 1, "Introduction," presents a survey of the techniques used in plant biotechnology laboratory procedures. Chapter 2, "Micronutrition," discusses media and nutritional requirements for tissue culture studies. Chapter 3, "Sterile Seeds," focuses on the…

  6. Brief history of the Cambridge STEM aberration correction project and its progeny.

    Science.gov (United States)

    Brown, L Michael; Batson, Philip E; Dellby, Niklas; Krivanek, Ondrej L

    2015-10-01

    We provide a brief history of the project to correct the spherical aberration of the scanning transmission electron microscope (STEM) that started in Cambridge (UK) and continued in Kirkland (WA, USA), Yorktown Heights (NY, USA), and other places. We describe the project in the full context of other aberration correction research and related work, partly in response to the incomplete context presented in the paper "In quest of perfection in electron optics: A biographical sketch of Harald Rose on the occasion of his 80th birthday", recently published in Ultramicroscopy. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. The political role of the State in Cambridge theories of growth and distribution

    Directory of Open Access Journals (Sweden)

    Sébastien Charles

    2007-12-01

    Full Text Available In this paper we extend Kaldor’s Neo-Pasinetti theorem to the scope of budgetary interventions based on political orientations. First, we take into account a system of taxes and expenditures. Second, we introduce different reaction functions for public spending showing the political role of the State in Cambridge theory of distribution. It turns out that the validity of Kaldorian results depends on the political orientation adopted by government, which diminishes the range of application of the Neo-Pasinetti theorem.

  8. The present state of research and exploitation of biotech (GM) crops in horticulture: results of research on plum cv. 'HoneySweet' resistant to plum pox virus (Sharka) and the deregulation of this cultivar in the CR & Europe

    Science.gov (United States)

    Gentically modified (GM) crops were grown world-wide on 160 million ha in 2011. Only 114.57 ha of GM crops were grown in Europe, of that, 114.90 ha were Bt maize and 17 ha were potato for industrial starch production. Commercialization of Biotech crops started in 1995. Currently, developing count...

  9. Technology Solutions Case Study: Boiler Control Replacement for Hydronically Heated Multifamily Buildings, Cambridge, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-11-01

    The ARIES Collaborative, a U.S. Department of Energy Building America research team, partnered with NeighborWorks America affiliate Homeowners' Rehab Inc. (HRI) of Cambridge, Massachusetts, to study improvements to the central hydronic heating system in one of the nonprofit's housing developments. The heating controls in the three-building, 42-unit Columbia Cambridge Alliance for Spanish Tenants housing development were upgraded. Fuel use in the development was excessive compared to similar properties. A poorly insulated thermal envelope contributed to high energy bills, but adding wall insulation was not cost-effective or practical. The more cost-effective option was improving heating system efficiency, which faced several obstacles, including inflexible boiler controls and failed thermostatic radiator valves. Boiler controls were replaced with systems that offer temperature setbacks and one that controls heat based on apartment temperature in addition to outdoor temperature. Utility bill analysis shows that post-retrofit weather-normalized heating energy use was reduced by 10%-31% (average of 19%). Indoor temperature cutoff reduced boiler runtime (and therefore heating fuel consumption) by 28% in the one building in which it was implemented. Nearly all savings were obtained during night which had a lower indoor temperature cut off (68°F) than day (73° F). This implies that the outdoor reset curve was appropriately adjusted for this building for daytime operation. Nighttime setback of heating system supply water temperature had no discernable impact on boiler runtime or gas bills.

  10. Building America Case Study: Boiler Control Replacement for Hydronically Heated Multifamily Buildings, Cambridge, Massachusetts (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2014-11-01

    The ARIES Collaborative, a U.S. Department of Energy Building America research team, partnered with NeighborWorks America affiliate Homeowners' Rehab Inc. (HRI) of Cambridge, Massachusetts, to study improvements to the central hydronic heating system in one of the nonprofit's housing developments. The heating controls in the three-building, 42-unit Columbia Cambridge Alliance for Spanish Tenants housing development were upgraded. Fuel use in the development was excessive compared to similar properties. A poorly insulated thermal envelope contributed to high energy bills, but adding wall insulation was not cost-effective or practical. The more cost-effective option was improving heating system efficiency. Efficient operation of the heating system faced several obstacles, including inflexible boiler controls and failed thermostatic radiator valves. Boiler controls were replaced with systems that offer temperature setbacks and one that controls heat based on apartment temperature in addition to outdoor temperature. Utility bill analysis shows that post-retrofit weather-normalized heating energy use was reduced by 10%-31% (average of 19%). Indoor temperature cutoff reduced boiler runtime (and therefore heating fuel consumption) by 28% in the one building in which it was implemented. Nearly all savings were obtained during night which had a lower indoor temperature cut off (68 degrees F) than day (73 degrees F). This implies that the outdoor reset curve was appropriately adjusted for this building for daytime operation. Nighttime setback of heating system supply water temperature had no discernable impact on boiler runtime or gas bills.

  11. Diagnosing Prosopagnosia: The Utility of Visual Noise in the Cambridge Face Recognition Test.

    Science.gov (United States)

    Corrow, Sherryse L; Albonico, Andrea; Barton, Jason J S

    2018-01-01

    Adding visual noise to facial images has been used to increase reliance on configural processing. Whether this enhances the ability of tests to diagnose prosopagnosia is not known. We examined 15 subjects with developmental prosopagnosia, 13 subjects with acquired prosopagnosia, and 38 control subjects with the Cambridge Face Memory Test. We compared their performance on the second phase, without visual noise, and on the third phase, which adds visual noise. We analyzed the results with signal detection theory methods. The performance of controls worsened more than did that of prosopagnosic subjects when noise was added. The second phase showed better ability to discriminate between prosopagnosic and control subjects than did the third phase. For developmental prosopagnosia, a test using only the 48 trials of the first and second phases yielded sensitivity of 88% and specificity of 91% with a criterion of 33/48 correct, performance characteristics that are similar for a criterion of 43/72 for the whole test. We conclude that a shortened Cambridge Face Memory Test without the noisy images may be a quicker yet equally effective instrument for diagnosing prosopagnosia. The theoretical advantage of noisy images is outweighed by the poorer performance of control subjects with visual noise.

  12. The factors influencing car use in a cycle-friendly city: the case of Cambridge.

    Science.gov (United States)

    Carse, Andrew; Goodman, Anna; Mackett, Roger L; Panter, Jenna; Ogilvie, David

    2013-04-01

    Encouraging people out of their cars and into other modes of transport, which has major advantages for health, the environment and urban development, has proved difficult. Greater understanding of the influences that lead people to use the car, particularly for shorter journeys, may help to achieve this. This paper examines the predictors of car use compared with the bicycle to explore how it may be possible to persuade more people to use the bicycle instead of the car. Multivariable logistic regression was used to examine the socio-demographic, transport and health-related correlates of mode choice for work, shopping and leisure trips in Cambridge, a city with high levels of cycling by UK standards. The key findings are that commuting distance and free workplace parking were strongly associated with use of the car for work trips, and car availability and lower levels of education were associated with car use for leisure, shopping and short-distanced commuting trips. The case of Cambridge shows that more policies could be adopted, particularly a reduction in free car parking, to increase cycling and reduce the use of the car, especially over short distances.

  13. Do the Cambridge Neuropsychological Test Automated Battery episodic memory measures discriminate amnestic mild cognitive impairment?

    Science.gov (United States)

    Juncos-Rabadán, Onésimo; Pereiro, Arturo X; Facal, David; Reboredo, Alba; Lojo-Seoane, Cristina

    2014-06-01

    Although visual recognition memory and visuospatial paired associates learning has been shown to be impaired in amnestic mild cognitive impairment (aMCI), the sensitivity and specificity of the visual memory tests used to identify aMCI are not well defined. The current study attempted to analyze the sensitivity and specificity of three visual episodic memory tests (Pattern Recognition Memory [PRM], Delayed Matching to Sample [DMS], and Paired Associated Learning [PAL]) from the CANTAB, in differentiating aMCI patients from control healthy participants. Seventy seven aMCI patients and 85 cognitive normal controls aged over 50 years performed the PRM, DMS, and PAL tests. Univariate and multivariate logistic regression and receiver operating characteristic curve analyses were used to study the relationships between aMCI and visual memory measures. The three Cambridge Neuropsychological Test Automated Battery measures significantly predicted aMCI. The optimal predictive model combined the total percent correct responses for PRM and DMS with the PAL total errors (six shapes adjusted), with a sensitivity of 72%, specificity of 83%, and achieved predictive accuracy of 80%. Visual episodic memory tasks such as those involved in the PRM, DMS, and PAL tests (included in the Cambridge Neuropsychological Test Automated Battery) may sensitively discriminate aMCI patients from normal controls. These tests may be useful for correct diagnosis of aMCI. Copyright © 2013 John Wiley & Sons, Ltd.

  14. Activity Limitation in Glaucoma: Objective Assessment by the Cambridge Glaucoma Visual Function Test.

    Science.gov (United States)

    Skalicky, Simon E; McAlinden, Colm; Khatib, Tasneem; Anthony, Louise May; Sim, Sing Yue; Martin, Keith R; Goldberg, Ivan; McCluskey, Peter

    2016-11-01

    We design and evaluate a computer-based objective simulation of activity limitation related to glaucoma. A cross-sectional study was performed involving 70 glaucoma patients and 14 controls. Mean age was 69.0 ± 10.2 years; 49 (58.3%) were male. The Cambridge Glaucoma Visual Function Test (CGVFT) was administered to all participants. Rasch analysis and criterion, convergent, and divergent validity tests assessed the psychometric properties of the CGVFT. Regression modeling was used to determine factors predictive of CGVFT person measures. Sociodemographic information, better and worse eye visual field parameters, visual acuity, contrast sensitivity, and the Rasch-analyzed Glaucoma Activity Limitation-9 (GAL-9) and Visual Function Questionnaire Utility Index (VFQUI) questionnaire responses were recorded. From 139 pilot CGVFT items, 59 had acceptable fit to the Rasch model, with acceptable precision (person separation index, 2.13) and targeting. Cambridge Glaucoma Visual Function Test person measure (logit) scores increased between controls (-0.20 ± 0.08) and patients with mild (-0.15 ± 0.08), moderate (-0.13 ± 0.10), and severe (-0.05 ± 0.10) glaucoma (P test administered to a cohort of glaucoma patients. It may benefit glaucoma patients, careers, health care providers, and policy makers, providing increased awareness of activity limitation due to glaucoma.

  15. The afterlife of Laurence Sterne (1713-1768): Body snatching, dissection and the role of Cambridge anatomist Charles Collignon.

    Science.gov (United States)

    Dittmar, Jenna M; Mitchell, Piers D

    2016-11-01

    This paper aims to highlight the practice of body snatching from graves in the 1700s for the purpose of providing corpses for anatomical dissection, and for stocking anatomy museums. To do this, we examine the exhumation and dissection of the famous eighteenth-century novelist Laurence Sterne and explore the involvement of Charles Collignon, Professor of Anatomy at the University of Cambridge. We also show that osteological and cut-mark analysis of a skull purported to be that of Sterne, currently housed in the Duckworth Collection at Cambridge, provides the key to solving the mystery surrounding why Sterne was resurrected. © The Author(s) 2015.

  16. Reginald Crundall Punnett: first Arthur Balfour Professor of Genetics, Cambridge, 1912.

    Science.gov (United States)

    Edwards, A W F

    2012-09-01

    R. C. Punnett, the codiscoverer of linkage with W. Bateson in 1904, had the good fortune to be invited to be the first Arthur Balfour Professor of Genetics at Cambridge University, United Kingdom, in 1912 when Bateson, for whom it had been intended, declined to leave his new appointment as first Director of the John Innes Horticultural Institute. We here celebrate the centenary of the first professorship dedicated to genetics, outlining Punnett's career and his scientific contributions, with special reference to the discovery of "partial coupling" in the sweet pea (later "linkage") and to the diagram known as Punnett's square. His seeming reluctance as coauthor with Bateson to promote the reduplication hypothesis to explain the statistical evidence for linkage is stressed, as is his relationship with his successor as Arthur Balfour Professor, R. A. Fisher. The background to the establishment of the Professorship is also described.

  17. [Screening for depersonalization-derealization with two items of the cambridge depersonalization scale].

    Science.gov (United States)

    Michal, Matthias; Zwerenz, Rüdiger; Tschan, Regine; Edinger, Jens; Lichy, Marcel; Knebel, A; Tuin, Inka; Beutel, Manfred

    2010-05-01

    Depersonalization (DP) and derealization (DR) are considered to be highly underdiagnosed. Therefore the development of screening instruments is important. From the Cambridge Depersonalization Scale (CDS) two items were extracted discriminating best patients with clinical significant DP from patients without DP. These two Items were assembled to a short version of the CDS. This short version (CDS-2) was tested in a sample of 38 patients with clinical significant DP-DR and 49 patients without or only mild DP-DR. Scores were compared against clinical diagnoses based on a structured interview (gold standard). The CDS-2 was able to differentiate patients with clinical significant DP well from other groups (cut-off of CDS-2>or=3, sensitivity=78.9%, specifity=85.7%) and also showed high reliability (Cronbachs alpha=0.92). Therefore the CDS-2 can be considered as a useful tool for screening and identification of DP-DR.

  18. Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge.

    Science.gov (United States)

    Fuchs, Julian E; Bender, Andreas; Glen, Robert C

    2015-09-01

    The Centre for Molecular Informatics, formerly Unilever Centre for Molecular Science Informatics (UCMSI), at the University of Cambridge is a world-leading driving force in the field of cheminformatics. Since its opening in 2000 more than 300 scientific articles have fundamentally changed the field of molecular informatics. The Centre has been a key player in promoting open chemical data and semantic access. Though mainly focussing on basic research, close collaborations with industrial partners ensured real world feedback and access to high quality molecular data. A variety of tools and standard protocols have been developed and are ubiquitous in the daily practice of cheminformatics. Here, we present a retrospective of cheminformatics research performed at the UCMSI, thereby highlighting historical and recent trends in the field as well as indicating future directions.

  19. Reginald Crundall Punnett: First Arthur Balfour Professor of Genetics, Cambridge, 1912

    Science.gov (United States)

    Edwards, A. W. F.

    2012-01-01

    R. C. Punnett, the codiscoverer of linkage with W. Bateson in 1904, had the good fortune to be invited to be the first Arthur Balfour Professor of Genetics at Cambridge University, United Kingdom, in 1912 when Bateson, for whom it had been intended, declined to leave his new appointment as first Director of the John Innes Horticultural Institute. We here celebrate the centenary of the first professorship dedicated to genetics, outlining Punnett’s career and his scientific contributions, with special reference to the discovery of “partial coupling” in the sweet pea (later “linkage”) and to the diagram known as Punnett’s square. His seeming reluctance as coauthor with Bateson to promote the reduplication hypothesis to explain the statistical evidence for linkage is stressed, as is his relationship with his successor as Arthur Balfour Professor, R. A. Fisher. The background to the establishment of the Professorship is also described. PMID:22964834

  20. Analysis of residue conformations in peptides in Cambridge structural database and protein-peptide structural complexes.

    Science.gov (United States)

    Raghavender, Upadhyayula Surya

    2017-03-01

    A comprehensive statistical analysis of the geometric parameters of peptide chains in a reduced dataset of protein-peptide complexes in Protein Data Bank (PDB) is presented. The angular variables describing the backbone conformations of amino acid residues in peptide chains shed insights into the conformational preferences of peptide residues interacting with protein partners. Nonparametric statistical approaches are employed to evaluate the interrelationships and associations in structural variables. Grouping of residues based on their structure into chemical classes reveals characteristic trends in parameter relationships. A comparison of canonical amino acid residues in free peptide structures in Cambridge structural database (CSD) with identical residues in PDB complexes, suggests that the information can be integrated from both the structural repositories enabling efficient and accurate modeling of biologically active peptides. © 2016 John Wiley & Sons A/S.

  1. Color discrimination across four life decades assessed by the Cambridge Colour Test.

    Science.gov (United States)

    Paramei, Galina V

    2012-02-01

    Color discrimination was estimated using the Cambridge Colour Test (CCT) in 160 normal trichromats of four life decades, 20-59 years of age. For each age cohort, medians and tolerance limits of the CCT parameters are tabulated. Compared across the age cohorts (Kruskal-Wallis test), the Trivector test showed increases in the three vectors, Protan, Deutan, and Tritan, with advancing age; the Ellipses test revealed significant elongation of the major axes of all three ellipses but no changes in either the axis ratio or the angle of the ellipse major axis. Multiple comparisons (Mann-Whitney test) between the cohorts of four age decades (20+,…,50+) revealed initial benign deterioration of color discrimination in the 40+ decade, as an incremental loss of discrimination along the Deutan axis (Trivector test), and in the 50+ decade, as an elongation of the major axes of all three ellipses (Ellipses test). © 2012 Optical Society of America

  2. Debate on Bruce Bimber´s Book Information and American Democracy. Cambridge University Press, 2003

    Directory of Open Access Journals (Sweden)

    Karpf, David

    2011-12-01

    Full Text Available Not availablePresentation José Manuel Robles Abstract of Information and American Democracy. Cambridge University Press, 2003 Bruce Bimber From Regimes to Ecologies: Globalizing Bruce Bimber’s Model of Information and Politics Steven Livingston Internet, new forms of power and democracy José Luís Garcia Internet: A Technological Tool and Changes in Political Power Liu Gang Information and American Democracy in the era of web 2.0 Lorenzo Mosca What Comes Next?: Bimber’s Information Revolutions and Institutional Disruptions David Karpf Online Political Information and Online Political Participation José Manuel Robles Digital Media and Political Change: A Response to Garcia, Karpf, Livingston, Liu, Mosca, and Robles Bruce Bimber

  3. A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments.

    Science.gov (United States)

    Smith, Patrick J; Need, Anna C; Cirulli, Elizabeth T; Chiba-Falek, Ornit; Attix, Deborah K

    2013-01-01

    The Cambridge Neuropsychological Test Automated Battery (CANTAB) is frequently used in research protocols and increasingly in clinical practice. Despite the frequency of its use, important aspects of its measurement validity have yet to be established in healthy adults. Two hundred and fifty-five individuals completed the CANTAB and traditional neuropsychological tests commonly used in clinical practice, including selected subtests from the Wechsler Adult Intelligence Scale, Controlled Oral Word Association Test, Animal Naming, Trail Making Tests A and B, the Stroop test, and the Green Story Recall test. Results showed that CANTAB subtests were modestly correlated with traditional subtests. Correlations between CANTAB subtests and traditional subtests were less consistent when age and education were controlled for. In conclusion, the CANTAB shows modest associations with traditional neuropsychological test measures.

  4. Fiftieth Anniversary of the Cambridge Structural Database and Thirty Years of Its Use in Croatia

    Directory of Open Access Journals (Sweden)

    Kojić-Prodić B.

    2015-07-01

    Full Text Available This article is dedicated to the memory of Dr. F. H. Allen and the 50th anniversary of the Cambridge Crystallographic Data Centre (CCDC; the world-renowned centre for deposition and control of crystallographic data including atomic coordinates that define the three-dimensional structures of organic molecules and metal complexes containing organic ligands. The mission exposed at the web site (http://www.ccdc.cam.ac.uk is clearly stated: “The Cambridge Crystallographic Data Centre (CCDC is dedicated to the advancement of chemistry and crystallography for the public benefit through providing high quality information, software and services.” The Cambridge Structural Database (CSD, one among the first established electronic databases, nowadays is one of the most significant crystallographic databases in the world. In the International Year of Crystallography 2014, the CSD announced in December over 750,000 deposited structures. The use of the extensive and rapidly growing database needs support of sophisticated and efficient software for checking, searching, analysing, and visualising structural data. The seminal role of the CSD in researches related to crystallography, chemistry, materials science, solid state physics and chemistry, (biotechnology, life sciences, and pharmacology is widely known. The important issues of the CCDC are the accuracy of deposited data and development of software for checking the data. Therefore, the Crystallographic Information File (CIF is introduced as the standard text file format for representing crystallographic information. Among the most important software for users is ConQuest, which enables searching all the CSD information fields, and the web implementation WebCSD software. Mercury is available for visualisation of crystal structures and crystal morphology including intra- and intermolecular interactions with graph-set notations of hydrogen bonds, and analysis of geometrical parameters. The CCDC gives even

  5. In Pursuit of Educational Integrity: Professional Identity Formation in the Harvard Medical School Cambridge Integrated Clerkship.

    Science.gov (United States)

    Gaufberg, Elizabeth; Bor, David; Dinardo, Perry; Krupat, Edward; Pine, Elizabeth; Ogur, Barbara; Hirsh, David A

    2017-01-01

    Graduates of Harvard Medical School's Cambridge Integrated Clerkship (CIC) describe several core processes that may underlie professional identity formation (PIF): encouragement to integrate pre-professional and professional identities; support for learner autonomy in discovering meaningful roles and responsibilities; learning through caring relationships; and a curriculum and an institutional culture that make values explicit. The authors suggest that the benefits of educational integrity accrue when idealistic learners inhabit an educational model that aligns with their own core values, and when professional development occurs in the context of an institutional home that upholds these values. Medical educators should clarify and animate principles within curricula and learning environments explicitly in order to support the professional identity formation of their learners.

  6. Possessing History and American Innocence: James Baldwin, William F. Buckley, Jr., and the 1965 Cambridge Debate

    Directory of Open Access Journals (Sweden)

    Daniel Robert McClure

    2016-12-01

    Full Text Available The 1965 debate at Cambridge University between James Baldwin and William F. Buckley, Jr., posed the question: “Has the American Dream been achieved at the Expense of the American Negro?” Within the contours of the debate, Baldwin and Buckley wrestled with the ghosts of settler colonialism and slavery in a nation founded on freedom and equality. Framing the debate within the longue durée, this essay examines the deep cultural currents related to the American racial paradox at the height of the Civil Rights movement. Underscoring the changing language of white resistance against black civil rights, the essay argues that the Baldwin and Buckley debate anticipated the ways the U.S. would address racial inequality in the aftermath of the civil rights era and the dawn of neoliberalism in the 1970s.

  7. A survey on worries of pregnant women - testing the German version of the Cambridge Worry Scale

    Directory of Open Access Journals (Sweden)

    Gensichen Jochen

    2009-12-01

    Full Text Available Abstract Background Pregnancy is a transition period in a woman's life characterized by increased worries and anxiety. The Cambridge Worry Scale (CWS was developed to assess the content and extent of maternal worries in pregnancy. It has been increasingly used in studies over recent years. However, a German version has not yet been developed and validated. The aim of this study was (1 to assess the extent and content of worries in pregnancy on a sample of women in Germany using a translated and adapted version of the Cambridge Worry Scale, and (2 to evaluate the psychometric properties of the German version. Methods We conducted a cross-sectional study and enrolled 344 pregnant women in the federal state of Baden-Württemberg, Germany. Women filled out structured questionnaires that contained the CWS, the Spielberger-State-Trait-Anxiety Inventory (STAI, as well as questions on their obstetric history. Antenatal records were also analyzed. Results The CWS was well understood and easy to fill in. The major worries referred to the process of giving birth (CWS mean value 2.26 and the possibility that something might be wrong with the baby (1.99, followed by coping with the new baby (1.57, going to hospital (1.29 and the possibility of going into labour too early (1.28. The internal consistency of the scale (0.80 was satisfactory, and we found a four-factor structure, similar to previous studies. Tests of convergent validity showed that the German CWS represents a different construct compared with state and trait anxiety but has the desired overlap. Conclusions The German CWS has satisfactory psychometric properties. It represents a valuable tool for use in scientific studies and is likely to be useful also to clinicians.

  8. The release of wastewater contaminants in the Arctic: A case study from Cambridge Bay, Nunavut, Canada.

    Science.gov (United States)

    Chaves-Barquero, Luis G; Luong, Kim Hoang; Mundy, C J; Knapp, Charles W; Hanson, Mark L; Wong, Charles S

    2016-11-01

    The treatment of municipal wastewater in the Arctic is challenging due to a variety of financial, operational, climatic and technical issues. To better understand the efficacy of current wastewater treatment in this region and the hazard posed to receiving waters, we assessed the occurrence of nutrients and contaminants (i.e., pharmaceuticals, antibiotic resistance genes) as they moved through a lagoon-based treatment system in Cambridge Bay, Nunavut, Canada. Wastewater treatment in this community is performed by the use of a lagoon-tundra wetland system that is discharged into the marine environment and is representative of current common practices throughout the region. In 2014, samples were collected before and during lagoon discharge from two locations in the main lagoon, one location downstream from the lagoon effluent and three locations offshore. Grab samples were collected to measure nutrients (e.g., total nitrogen and phosphorus) and the presence of antibiotic resistance gene-bearing microbes, and Polar Organic Chemical Integrative Samplers (POCIS) were deployed to collect passively organic contaminants in all locations. A total of six pharmaceuticals were detected from a screen of twenty-eight analytes during the study: atenolol, carbamazepine, clarithromycin, metoprolol, sulfamethoxazole and trimethoprim. The greatest concentrations of nutrients, antibiotic resistance genes (ARGs), and pharmaceuticals were found in sampling locations within the treatment lagoon. Offshore of the release point, we observed limited to no detection of pharmaceuticals and ARGs, but no change in total nitrogen and phosphorus from pre-release. We conclude that the current concentrations of monitored pharmaceuticals do not pose a significant hazard at this time to aquatic organisms in Cambridge Bay. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosis.

    Science.gov (United States)

    Roldán, Vanessa; Ordoñez, Adriana; Marín, Francisco; Zorio, Esther; Soria, José M; Miñano, Antonia; España, Francisco; González-Conejero, Rocio; Pineda, Javier; Estellés, Amparo; Fontcuberta, Jordi; Vicente, Vicente; Corral, Javier

    2009-03-01

    Although the control of thrombin in the microvasculature at the endothelial cell surface is crucial to prevent atherothrombosis, the role of antithrombin in arterial thrombosis is unclear. It is widely considered that antithrombin deficiency is unlikely to contribute to arterial thrombosis, but no convincing epidemiological study has been performed because of the low frequency of this deficiency. In this study we evaluated the role in myocardial infarction (MI) of a relatively common mutation affecting antithrombin gene (A384S: Antithrombin Cambridge II) that has functional features that may impair the right control of thrombogenic events caused by injury to the vascular wall. Moreover, this deficiency, which is not detected using common methods to diagnose antithrombin deficiency, also increases the risk of venous thrombosis. We included 1,224 patients with MI (691 consecutive patients and 533 survivors of a premature event), and 1,649 controls. The mutation was identified in 0.3% of controls, but 0.8% of MI patients. After adjusting for sex and other cardiovascular risk factors, the antithrombin Cambridge II significantly increased 5.66-fold the risk of MI (95% CI: 1.53-20.88; p = 0.009). Interestingly, young patients had the highest risk of MI associated with the mutation (OR: 9.98; 95%CI: 1.60-62.24; p = 0.009). This is the first epidemiological study that supports a role for antithrombin deficiency in arterial thrombosis. These results suggest that deficiency of antithrombin may be an independent risk factor for MI that has been underestimated, but larger studies are needed to confirm the relevance of inhibitors of thrombin in arterial thrombosis.

  10. A computer-controlled color vision test for children based on the Cambridge Colour Test.

    Science.gov (United States)

    Goulart, Paulo R K; Bandeira, Marcio L; Tsubota, Daniela; Oiwa, Nestor N; Costa, Marcelo F; Ventura, Dora F

    2008-01-01

    The present study aimed at providing conditions for the assessment of color discrimination in children using a modified version of the Cambridge Colour Test (CCT, Cambridge Research Systems Ltd., Rochester, UK). Since the task of indicating the gap of the Landolt C used in that test proved counterintuitive and/or difficult for young children to understand, we changed the target stimulus to a patch of color approximately the size of the Landolt C gap (about 7 degrees of visual angle at 50 cm from the monitor). The modifications were performed for the CCT Trivector test which measures color discrimination for the protan, deutan and tritan confusion lines. Experiment 1 sought to evaluate the correspondence between the CCT and the child-friendly adaptation with adult subjects (n = 29) with normal color vision. Results showed good agreement between the two test versions. Experiment 2 tested the child-friendly software with children 2 to 7 years old (n = 25) using operant training techniques for establishing and maintaining the subjects' performance. Color discrimination thresholds were progressively lower as age increased within the age range tested (2 to 30 years old), and the data--including those obtained for children--fell within the range of thresholds previously obtained for adults with the CCT. The protan and deutan thresholds were consistently lower than tritan thresholds, a pattern repeatedly observed in adults tested with the CCT. The results demonstrate that the test is fit for assessment of color discrimination in young children and may be a useful tool for the establishment of color vision thresholds during development.

  11. Bericht uber den 2. Internationalen Kongress fur Angewandte Linguistik. Cambridge 8.-12. IX. 1969. [Report on the Second International Congress for Applied Linguistics, Cambridge, Dec. 8-12, 1969.

    Science.gov (United States)

    Mohr, Peter

    This paper is a summary report on the Second International Congress of Applied Linguistics held in Cambridge, England in September 1969. Because of the large number of papers delivered, only a selection of the papers delivered in any one section of the Congress are considered, and the author attempts to identify current interests and trends in…

  12. First record of Centromerus arcanus (O. P.-Cambridge, 1873) from Greenland (Araneae, Linyphiidae)

    DEFF Research Database (Denmark)

    Lissner, Jørgen; Gravesen, Eigil Vestergaard

    2017-01-01

    The linyphiid spider Centromerus arcanus (O. P.-Cambridge, 1873) is reported new to Greenland. A single female was pitfall trapped in South-West Greenland at Kobbefjord in the summer of 2016 constituting the first record of this species in the Nearctic ecozone. The habitat in which the Greenland ...

  13. M-DCPS Student Performance in International Baccalaureate and Cambridge Advanced International Certificate of Education Programs. Research Brief. Volume 1102

    Science.gov (United States)

    Blazer, Christie

    2011-01-01

    This Research Brief summarizes the performance of M-DCPS students participating in the International Baccalaureate (IB) and Cambridge Advanced International Certificate of Education (AICE) programs. Outcome data are provided for the eight M-DCPS schools offering the two programs and corresponding examinations. Participation in international…

  14. CAMDEX-N: de Nederlandse versie van de Cambridge Examination for Mental Disorders of the Elderly met geautomatiseerde dataverwerking

    NARCIS (Netherlands)

    Derix, M. M.; Hofstede, A. B.; Teunisse, S.; Hijdra, A.; Walstra, G. J.; Weinstein, H. C.; van Gool, W. A.

    1991-01-01

    In the study of dementia four distinct categories of instruments can be distinguished: instruments to examine cognitive dysfunction, to measure the severity of dementia, to assess disturbances in daily behaviour, and instruments to make a differential diagnosis of dementia. The Cambridge Examination

  15. Degrees of Influence: The Politics of Honorary Degrees in the Universities of Oxford and Cambridge, 1900-2000

    Science.gov (United States)

    Heffernan, Michael; Jons, Heike

    2007-01-01

    The universities of Oxford and Cambridge had developed different attitudes towards the award of honorary degrees through the early and middle decades of the twentieth century. Recently, both have adopted a similar cautious and apolitical stance. This essay describes the role of honorary degrees in the production and reproduction of their cultural…

  16. More Effective ABE Instruction for Institutionalized Adult Alcoholics and Addicts through the Cambridge Kentucky GED Video Series. Final Report.

    Science.gov (United States)

    Mellon, Thomas A.

    A project was conducted to evaluate the effectiveness of the Cambridge/Kentucky Educational Television General Educational Development (GED) Video Series as a tool for providing adult basic education (ABE) instruction to institutionalized drug addicts and alcoholics at Eagleville Hospital in Eagleville, Pennsylvania. After the integration of the…

  17. Tartu Ülikooli teadur kaitses Cambridgeì Ülikoolis doktorikraadi / Krõõt Nõges

    Index Scriptorium Estoniae

    Nõges, Krõõt

    2006-01-01

    Tartu Ülikooli filosoofia osakonna teadur ja eetikakeskuse stipendiaat Eva Piirimäe kaitses Cambridgeì Ülikoolis doktorikraadi ideede ajaloo erialal doktoritööga "Thomas Abbt (1738-1766) and the Philosophical Genesis of German Nationalism"

  18. A Passport Photo of Two: On an Allusion in the Pictures of Wittgenstein and von Wright in Cambridge

    Directory of Open Access Journals (Sweden)

    Christian Eric Erbacher

    2014-06-01

    Full Text Available The article draws a connection between three items preserved at the von Wright and Wittgenstein Archives at the University of Helsinki (WWA, namely a book by Wilhelm Busch and two copies of the photos of von Wright and Wittgenstein in Cambridge taken by Knut Erik Tranøy in 1950, by suggesting that the photos contain an allusion by Wittgenstein.

  19. Assessing the Impact of the Cambridge International Acceleration Program on U.S. University Determinants of Success: A Multi-Level Modeling Approach

    Science.gov (United States)

    Shaw, Stuart; Warren, Jayne; Gill, Tim

    2014-01-01

    This article focuses on the research being conducted by Cambridge International Examinations (Cambridge) to ensure that its international assessments prepare students as well as other acceleration programs for continued study in U.S. colleges and universities. The study, which builds on previous freshman GPA data modeling work using data supplied…

  20. BOOK REVIEW - The Experience of Face Veil Wearers in Europe and the Law (Cambridge University Press United Kingdom 2014). ISBN 978-1-107-05830-9.

    OpenAIRE

    Jacques L Matthee

    2017-01-01

    This contribution published by Cambridge University Press provides a short overview of the book by Eva Brems "The Experience of Face Veil Wearers in Europe and the Law" published by Cambridge University Press, United Kingdom, in 2014. See ISBN 978-1-107-05830-9.

  1. Factor structure of the Cambridge Depersonalization Scale in trauma-exposed college students.

    Science.gov (United States)

    Blevins, Christy A; Witte, Tracy K; Weathers, Frank W

    2013-01-01

    This study examined the factor structure of the Cambridge Depersonalization Scale (CDS; M. Sierra & G. E. Berrios, 2000 ), a 29-item self-report measure of depersonalization. The CDS was based on a conceptualization of depersonalization as a multidimensional construct, a theoretical perspective that has received limited empirical attention. Exploratory and confirmatory factor analyses were conducted on CDS item scores in a sample of 534 trauma-exposed college students. Results failed to support factor structures of the CDS previously reported in the literature and instead supported a 2-factor solution, with 1 factor representing a sense of unreality and detachment and a 2nd factor representing emotional and physical numbing. Implications regarding the structural validity of the CDS are discussed. [Supplementary material is available for this article. Go to the publisher's online edition of Journal of Trauma & Dissociation for the following resource: Four tables with the following information: inter-correlations among CDS items from Samples 1 and 2; Sierra et al. (2005 ) four-factor model and Simeon et al. (2008 ) five-factor model estimated factor loadings, covariances, and R-square in Sample 1; Factor loadings for 3-7 factor EFA models in Sample 1; and estimated factor loadings for one-factor CFA model in Sample 2.].

  2. Normal range of cambridge low contrast test; a population based study.

    Science.gov (United States)

    Ostadimoghaddam, Hadi; Fotouhi, Akbar; Hashemi, Hassan; Yekta, Abbas Ali; Heravian, Javad; Abdolahinia, Tahereh; Norouzi Rad, Reza; Asgari, Soheila; Khabazkhoob, Mehdi

    2014-01-01

    To determine the range of contrast sensitivity (CS) and its determinants in a normal population, Mashhad, Iran. In this cross-sectional population based study, 4,453 individuals were invited of whom 3,132 persons agreed to participate (response rate, 70.4%). CS data from 2,449 eligible individuals were analyzed. CS was determined using the Cambridge low contrast square-wave grating test, and its associations with age, gender, best-corrected visual acuity (BCVA) and manifest refraction spherical equivalent (MRSE) refractive error, were analyzed. Mean age of the participants was 29.1±17.3 (range, 4-89) years and 66.4% were female. Mean CS was 239.6±233.3 and 234.6±228.6 cps in right and left eyes, respectively. Mean binocular CS was 310.9±249.0 cps. Multiple linear regression showed that CS was inversely correlated with older age (β=-1.1, PCambridge low-contrast grating test reported herein may serve as a reference for the general population in Iran. Our findings can be used for both research and clinical applications, particularly for evaluations of the outcomes of refractive surgery. In the current study, CS was lower in older subjects, myopic individuals and patients with lower BCVA.

  3. Testing the Cambridge Quality Checklists on a review of disrupted families and crime

    Science.gov (United States)

    Jolliffe, Darrick; Murray, Joseph; Farrington, David; Vannick, Claire

    2012-01-01

    Background Systematic reviews of the relationship between non-manipulated factors (e.g. low empathy) and offending are becoming more common, and it is important to consider the methodological quality of studies included in such reviews. Aims To assess aspects of the reliability and validity of the Cambridge Quality Checklists, a set of three measures for examining the methodological quality of studies included in systematic reviews of risk factors for offending. Methods All 60 studies in a systematic review of disrupted families and offending were coded on the CQC and codes compared with the effect sizes derived from the studies. Results Overall, the CQC was easy to score, and the relevant information was available in most studies. The scales had high inter-rater reliability. Only 13 studies scored high on the Checklist of Correlates, 18 scored highly on the Checklist of Risk Factors and none scored highly on the Checklist of Causal Risk Factors. Generally, studies that were of lower quality had higher effect sizes. Conclusions The CQC could be a useful method of assessing the methodological quality of studies of risk factors for offending but might benefit from additional conceptual work, changes to the wording of some scales and additional levels for scoring. Copyright © 2012 John Wiley & Sons, Ltd. PMID:23192977

  4. Diagnosing prosopagnosia in East Asian individuals: Norms for the Cambridge Face Memory Test-Chinese.

    Science.gov (United States)

    McKone, Elinor; Wan, Lulu; Robbins, Rachel; Crookes, Kate; Liu, Jia

    2017-07-01

    The Cambridge Face Memory Test (CFMT) is widely accepted as providing a valid and reliable tool in diagnosing prosopagnosia (inability to recognize people's faces). Previously, large-sample norms have been available only for Caucasian-face versions, suitable for diagnosis in Caucasian observers. These are invalid for observers of different races due to potentially severe other-race effects. Here, we provide large-sample norms (N = 306) for East Asian observers on an Asian-face version (CFMT-Chinese). We also demonstrate methodological suitability of the CFMT-Chinese for prosopagnosia diagnosis (high internal reliability, approximately normal distribution, norm-score range sufficiently far above chance). Additional findings were a female advantage on mean performance, plus a difference between participants living in the East (China) or the West (international students, second-generation children of immigrants), which we suggest might reflect personality differences associated with willingness to emigrate. Finally, we demonstrate suitability of the CFMT-Chinese for individual differences studies that use correlations within the normal range.

  5. Experience from two decades of the Cambridge Rapid Access Neurology Clinic.

    Science.gov (United States)

    Axinte, Laura T; Fiddes, Barnaby D; Donaghy, Alastair; Whyte, Adam; Allen, Chris; Sawcer, Stephen J; Adam, Robert J; Stacpoole, Sybil R L

    2015-10-01

    We report on the evolution of the rapid access neurology clinic (established in 1995) at Addenbrooke's Hospital, Cambridge. Annualised attendance data demonstrate an ever increasing demand, with primary headache disorders now accounting for more than 40% of referrals. Secondary causes of headache (including intracranial tumours, idiopathic intracranial hypertension, carotid or vertebral artery dissection and subdural haematomas) remain infrequent. In all such cases, there were additional diagnostic clues. The number of patients referred with problems related to chronic neurological diseases has fallen considerably, reflecting the roles of specialist nurses and clinics. Imaging investigation of choice shifted from computerised tomography scan (45 to 16%) towards magnetic resonance imaging (17 to 47%). Management is increasingly on an outpatient basis, often without the need for a follow-up appointment. The experience presented here should inform further development of rapid access neurology clinics across the UK and suggests the need for acute headache services, in line with those for transient ischaemic attack and first seizure. © Royal College of Physicians 2015. All rights reserved.

  6. Characteristic Conformation of Mosher’s Amide Elucidated Using the Cambridge Structural Database

    Directory of Open Access Journals (Sweden)

    Akio Ichikawa

    2015-07-01

    Full Text Available Conformations of the crystalline 3,3,3-trifluoro-2-methoxy-2-phenylpropanamide derivatives (MTPA amides deposited in the Cambridge Structural Database (CSD were examined statistically as Racid-enantiomers. The majority of dihedral angles (48/58, ca. 83% of the amide carbonyl groups and the trifluoromethyl groups ranged from –30° to 0° with an average angle θ1 of −13°. The other conformational properties were also clarified: (1 one of the fluorine atoms was antiperiplanar (ap to the amide carbonyl group, forming a staggered conformation; (2 the MTPA amides prepared from primary amines showed a Z form in amide moieties; (3 in the case of the MTPA amide prepared from a primary amine possessing secondary alkyl groups (i.e., Mosher-type MTPA amide, the dihedral angles between the methine groups and the carbonyl groups were syn and indicative of a moderate conformational flexibility; (4 the phenyl plane was inclined from the O–Cchiral bond of the methoxy moiety with an average dihedral angle θ2 of +21°; (5 the methyl group of the methoxy moiety was ap to the ipso-carbon atom of the phenyl group.

  7. Characteristic conformation of Mosher's amide elucidated using the cambridge structural database.

    Science.gov (United States)

    Ichikawa, Akio; Ono, Hiroshi; Mikata, Yuji

    2015-07-16

    Conformations of the crystalline 3,3,3-trifluoro-2-methoxy-2-phenylpropanamide derivatives (MTPA amides) deposited in the Cambridge Structural Database (CSD) were examined statistically as Racid-enantiomers. The majority of dihedral angles (48/58, ca. 83%) of the amide carbonyl groups and the trifluoromethyl groups ranged from -30° to 0° with an average angle θ1 of -13°. The other conformational properties were also clarified: (1) one of the fluorine atoms was antiperiplanar (ap) to the amide carbonyl group, forming a staggered conformation; (2) the MTPA amides prepared from primary amines showed a Z form in amide moieties; (3) in the case of the MTPA amide prepared from a primary amine possessing secondary alkyl groups (i.e., Mosher-type MTPA amide), the dihedral angles between the methine groups and the carbonyl groups were syn and indicative of a moderate conformational flexibility; (4) the phenyl plane was inclined from the O-Cchiral bond of the methoxy moiety with an average dihedral angle θ2 of +21°; (5) the methyl group of the methoxy moiety was ap to the ipso-carbon atom of the phenyl group.

  8. Evaluation of the Tosoh G8 Analyzer and Comparison with the Trinity Biotech Premier Hb9210 Analyzer for the Measurement of HbA₁c.

    Science.gov (United States)

    Ucar, Fatma; Erden, Gonul; Ozdemir, Seyda; Yildiz, Zeynep; Arzuhal, Abdullah Ercan; Temel, Ismail

    2016-01-01

    The aim of our study was to assess the analytical performance of the Tosoh HLC-723G8 automated analyzer and to compare it with the Trinity Biotech Premier Hb9210 analyzer for the measurement of hemoglobin A₁c (HbA₁c). A total of 101 patients with pre-diabetes or diabetes mellitus were included in the study. HbA₁c, was measured by both an ion-exchange high-performance liquid chromatography (IE-HPLC) method and a boronate affinity chromatography method. Statistical analysis was performed using Deming regression. Bland-Altman plots were used to calculate mean difference (bias). The CV% values of IE-HPLC and boronate affinity methods for within run and between days were lower than 2.0%. High correlation was found (y = 1.0045x + 0.2111; r = 0.9941) between the two methods. The method shows no interference from carbamylated hemoglobin. Both systems showed acceptable performance and are suitable for clinical application in the analysis of HbA₁c. However, laboratories should be aware of the limitations of their methods and the availability of more accurate and precise HbA₁c, determination methods.

  9. Development of the Fray-Farthing-Chen Cambridge Process: Towards the Sustainable Production of Titanium and Its Alloys

    Science.gov (United States)

    Hu, Di; Dolganov, Aleksei; Ma, Mingchan; Bhattacharya, Biyash; Bishop, Matthew T.; Chen, George Z.

    2018-02-01

    The Kroll process has been employed for titanium extraction since the 1950s. It is a labour and energy intensive multi-step semi-batch process. The post-extraction processes for making the raw titanium into alloys and products are also excessive, including multiple remelting steps. Invented in the late 1990s, the Fray-Farthing-Chen (FFC) Cambridge process extracts titanium from solid oxides at lower energy consumption via electrochemical reduction in molten salts. Its ability to produce alloys and powders, while retaining the cathode shape also promises energy and material efficient manufacturing. Focusing on titanium and its alloys, this article reviews the recent development of the FFC-Cambridge process in two aspects, (1) resource and process sustainability and (2) advanced post-extraction processing.

  10. Adaptation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) into French-Canadian and English-Canadian

    OpenAIRE

    Donna Coffin; Karine Duval; Simon Martel; John Granton; Marie-Claude Lefebvre; Meads, David M.; James Twiss; McKenna, Stephen P.

    2008-01-01

    BACKGROUND: The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is the first disease-specific instrument for assessing patient-reported symptoms, functioning and quality of life (QoL) in pulmonary arterial hypertension (PAH).OBJECTIVES: To create and validate French-Canadian (FC) and English-Canadian (EC) language versions of the CAMPHOR.METHODS: A translation panel (for the FC version) and lay panels (for both versions) were convened to adapt the questionnaires (dual-panel methodol...

  11. The Cambridge Face Tracker: Accurate, Low Cost Measurement of Head Posture Using Computer Vision and Face Recognition Software.

    Science.gov (United States)

    Thomas, Peter B M; Baltrušaitis, Tadas; Robinson, Peter; Vivian, Anthony J

    2016-09-01

    We validate a video-based method of head posture measurement. The Cambridge Face Tracker uses neural networks (constrained local neural fields) to recognize facial features in video. The relative position of these facial features is used to calculate head posture. First, we assess the accuracy of this approach against videos in three research databases where each frame is tagged with a precisely measured head posture. Second, we compare our method to a commercially available mechanical device, the Cervical Range of Motion device: four subjects each adopted 43 distinct head postures that were measured using both methods. The Cambridge Face Tracker achieved confident facial recognition in 92% of the approximately 38,000 frames of video from the three databases. The respective mean error in absolute head posture was 3.34°, 3.86°, and 2.81°, with a median error of 1.97°, 2.16°, and 1.96°. The accuracy decreased with more extreme head posture. Comparing The Cambridge Face Tracker to the Cervical Range of Motion Device gave correlation coefficients of 0.99 ( P Cambridge Face Tracker performs well under real-world conditions and within the range of normally-encountered head posture. It allows useful quantification of head posture in real time or from precaptured video. Its performance is similar to that of a clinically validated mechanical device. It has significant advantages over other approaches in that subjects do not need to wear any apparatus, and it requires only low cost, easy-to-setup consumer electronics. Noncontact assessment of head posture allows more complete clinical assessment of patients, and could benefit surgical planning in future.

  12. On four new species of the jumping spider genus Mago O. Pickard-Cambridge, 1882 from South America (Araneae: Salticidae).

    Science.gov (United States)

    Costa, Erika L S; Ruiz, Gustavo R S

    2017-10-10

    Four new species of Mago O. Pickard-Cambridge, 1882 are described. Mago furcatus sp. nov. and Mago mimicus sp. nov. are described from Ecuador (Orellana and Napo provinces, respectively), both based only on the male holotypes. Both sexes of Mago pardo sp. nov. and the male of Mago apophysis sp. nov. are also described from the state of Pará, Brazil. A map with records of these species is given.

  13. John Howard Marsden (1803–1891 First Disney Professor of Archaeology at the University of Cambridge 1851–1865

    Directory of Open Access Journals (Sweden)

    Michael Leach

    2007-05-01

    Full Text Available Although there were ten chairs of archaeology at universities in Germany, and one in France, by the mid-nineteenth century, in Great Britain it was the amateur societies and museums (the British Museum in particular that encouraged the study of this subject. In 1851 John Disney established the first university chair in Great Britain at Cambridge University. His proposal was initially received with considerable caution by the governing body of the university, and was only accepted by the narrowest margin of eight votes to seven. His agreement with the University of Cambridge stipulated that six lectures a year should be given on the subject of ‘Classical, Medieval, and other Antiquities, the Fine Arts and all matters and things connected therewith’ (Clark 1904, 222–225. However university archaeology was slow to establish its academic credibility nationally, and it was more than thirty years before Oxford University established its chair of classical archaeology. The Cambridge Board of Anthropological Studies, which included instruction in prehistoric archaeology, was not created until 1915, and as late as 1945 there were still only a few university lecturers in archaeology in Great Britain. It was not until 1946 that Oxford University appointed a Professor of Prehistoric Archaeology (Wilson 2002, 153; Daniel 1976, 6–12; Smith 2004, 4–5, 53–54.

  14. A robust method of measuring other-race and other-ethnicity effects: the Cambridge Face Memory Test format.

    Science.gov (United States)

    McKone, Elinor; Stokes, Sacha; Liu, Jia; Cohan, Sarah; Fiorentini, Chiara; Pidcock, Madeleine; Yovel, Galit; Broughton, Mary; Pelleg, Michel

    2012-01-01

    Other-race and other-ethnicity effects on face memory have remained a topic of consistent research interest over several decades, across fields including face perception, social psychology, and forensic psychology (eyewitness testimony). Here we demonstrate that the Cambridge Face Memory Test format provides a robust method for measuring these effects. Testing the Cambridge Face Memory Test original version (CFMT-original; European-ancestry faces from Boston USA) and a new Cambridge Face Memory Test Chinese (CFMT-Chinese), with European and Asian observers, we report a race-of-face by race-of-observer interaction that was highly significant despite modest sample size and despite observers who had quite high exposure to the other race. We attribute this to high statistical power arising from the very high internal reliability of the tasks. This power also allows us to demonstrate a much smaller within-race other ethnicity effect, based on differences in European physiognomy between Boston faces/observers and Australian faces/observers (using the CFMT-Australian).

  15. A robust method of measuring other-race and other-ethnicity effects: the Cambridge Face Memory Test format.

    Directory of Open Access Journals (Sweden)

    Elinor McKone

    Full Text Available Other-race and other-ethnicity effects on face memory have remained a topic of consistent research interest over several decades, across fields including face perception, social psychology, and forensic psychology (eyewitness testimony. Here we demonstrate that the Cambridge Face Memory Test format provides a robust method for measuring these effects. Testing the Cambridge Face Memory Test original version (CFMT-original; European-ancestry faces from Boston USA and a new Cambridge Face Memory Test Chinese (CFMT-Chinese, with European and Asian observers, we report a race-of-face by race-of-observer interaction that was highly significant despite modest sample size and despite observers who had quite high exposure to the other race. We attribute this to high statistical power arising from the very high internal reliability of the tasks. This power also allows us to demonstrate a much smaller within-race other ethnicity effect, based on differences in European physiognomy between Boston faces/observers and Australian faces/observers (using the CFMT-Australian.

  16. Test well DO-CE 88 at Cambridge, Dorchester County, Maryland

    Science.gov (United States)

    Trapp, Henry; Knobel, LeRoy L.; Meisler, Harold; Leahy, P. Patrick

    1984-01-01

    Test well DO-CE 88 at Cambridge, Maryland, penetrated 3,299 feet of unconsolidated Quaternary, Tertiary and Cretaceous sediments and bottomed in quartz-monzonite gneiss. The well was drilled to provide data for a study of the aquifer system of the northern Atlantic Coastal Plain. Twenty-one core samples were collected. Six sand zones were tested for aquifer properties and sampled for ground-water chemistry. Point-water heads were measured at seven depths. Environmental heads (which ranged from - 18.33 to + 44.16 feet relative to sea level)indicate an upward component of flow. A temperature log showed a maximum temperature of 41.9 degrees Celsius and a mean temperature gradient of 0.00838 degrees Celsius per foot. The water analyses delineated the freshwater-saltwater transition zone between 2,650 and 3,100 feet. The ground water changes progressively downward from a sodium bicarbonate to a sodium chloride character. Clays in the analyzed core samples belong to the montmorillonite and kaolinite groups, and mean cation exchange capacity ranged from 8.3 to 38.9 milliequivalents per 100 grams. Vertical and horizontal hydraulic conductivities measured in cores ranged from 1.5 x 10 6 to 1.3 feet per day and from 7.3 x 10 -6 to 1.3 feet per day, respectively, but the most permeable sands were not cored. Porosity was 1.5 percent in the quartz monzonite bedrock and ranged from 22.4 to 41 percent in the overlying sediments. Transmissivities from aquifer tests ranged from 25 to 850 feet squared per day; horizontal hydraulic conductivities ranged from.2.5 to 85 feet squared per day, and intrinsic permeabilities ranged from 0.8 to 23 micrometers squared. Fossils identified in core samples include palynomorphs, dinoflagellates, and foraminifers.

  17. Depersonalization: An exploratory factor analysis of the Italian version of the Cambridge Depersonalization Scale.

    Science.gov (United States)

    Fagioli, F; Telesforo, L; Dell'Erba, A; Consolazione, M; Migliorini, V; Patanè, M; Boldrini, T; Graziani, R; Nicoletti, F; Fiori-Nastro, P

    2015-07-01

    "Depersonalization" (DP) is a common symptom in the general population and psychiatric patients (Michal et al., 2011 [1]). DP is characterized by an alteration in the experience of the self, so that one feels detached from his or her own mental processes or body (or from the world), feeling as being an outside observer of his or her own self, and loosing the experience of unity and identity (American Psychiatric Association, 2013 [2]). We performed an exploratory factor analysis of the Cambridge Depersonalization Scale Italian version (CDS-IV). We enrolled 149 inpatients and outpatients of psychiatric services located in two Italian regions, Lazio and Campania. Patients were aged between 15 and 65 and diagnosed with schizophrenic, depressive or anxiety disorders. Four factors accounted for 97.4% of the variance. Factor 1 (10, 24, 26, 1, 13, 23, 9, 2, 5, and 11), called "Detachment from the Self", captures experiences of detachment from actions and thoughts. Factor 2 (19, 20, 27, 3, 12, 23, 22, and 11), called "Anomalous bodily experiences", refers to unusual bodily experiences. Factor 3 (7, 28, 25, 6, 9, and 2), named "Numbing", describes the dampening of affects. Factor 4 (14, 17, and 16), named "Temporal blunting", refers to the subjective experience of time. We did not find any specific factor that refers to derealization; this suggests that the constructs of depersonalization/derealization (DP/DR) were strongly related to each other. Our results show that the constructs of DP/DR subsume several psychopathological dimensions; moreover, the above mentioned factors were broadly consistent with prior literature. Copyright © 2015. Published by Elsevier Inc.

  18. RELIABILITY, VALIDITY, AND PSYCHOMETRIC PROPERTIES OF THE GREEK TRANSLATION OF THE CAMBRIDGE DEPERSONALIZATION SCALE (CDS).

    Science.gov (United States)

    Kontoangelos, Konstantinos; Tsiori, Sofia; Poulakou, Garyfalia; Protopapas, Konstantinos; Katsarolis, Ioannis; Sakka, Vissaria; Kavatha, Dimitra; Papadopoulos, Antonios; Antoniadou, Anastasia; Papageorgiou, Charalambos C

    2016-10-01

    The Cambridge Depersonalisation Scale is meant to capture the frequency and duration of depersonalisation symptoms over the 'last 6 months'. In order to develop a Greek version of CDS scale, the CDS scale was translated in Greek by 2 psychiatrists. Then, the Greek version of CDS scale was back-translated by a person who did not knew the original English version. The back-translated version was reviewed in order to establish whether is consistent with the original English version. After this procedure we administered the Greek version of CDS scale to a sample of 294 Greeks in order to assess the reliability and the validity of the Greek version of scale. The five components solution accounted for 58.204% of the total variation. Initial eigenvalues of the five components were: factor 1=11.555, factor 2=1.564, factor 3=1.356, factor 4=1.247 and factor 5=1.157. Six items did not load on any factor. Correlations between factors were low ranged from 0.134 to 0.314 and no complex variables were found. Cronbach's alpha and Guttman split-half coefficient were used to evaluate interval consistency of CDS scale in 294 individuals. The alpha coefficients and Guttman split-half coefficient of the CDS scale were 0.938 and 0.921, respectively. The test-retest reliability proved to be satisfactory. The intraclass correlation coefficients for the total CDS score was very good and equal to 0,883. The CDS scale correlated highly with the SCL-90 and all subscales (p-value<0.0001). The psychometric strength of CDS - Greek its reliable for its future use, particularly for screening for subjects with possible diagnosis of CDS.

  19. Validation of the Cambridge Prospective Memory Test (Hong Kong Chinese version) for people with stroke.

    Science.gov (United States)

    Man, David W K; Chan, M K L; Yip, C C K

    2015-01-01

    This study aimed to develop and evaluate a Hong Kong Chinese version of the Cambridge Prospective Memory Test (CAMPROMPT-HKCV). Thirty-three subjects at least one year post-stroke participated in the study. They were simultaneously rated on version A of the CAMPROMPT-HKCV by two testers to establish its internal consistency and inter-rater reliability. Raters used the parallel versions of the test (A and B), in rating 10 patients within 2 weeks to establish the parallel form reliability. Another 10 were also assessed on the same day using both version A of the CAMPROMPT-HKCV and the Rivermead Behavioural Memory Test-Chinese version (RBMT-CV) to establish concurrent validity. A new group of 40 stroke patients and 44 healthy controls was recruited to establish its sensitivity and specificity. Results indicated that test-retest reliability on time-based, event-based and total scores, and inter-rater reliability for versions A and B of the test were high. Cronbach's alpha of the event-based score was higher than that of the time-based score. The reliability and concurrent validity of the parallel forms were established. There was a significant difference in performance on CAMPROMPT-HKCV (version A) between the stroke group and the healthy control group. ROC analysis showed that the ability of the cut-off CAMPROMPT-HKCV (total score) to differentiate PM problems was 20.5 (out of 36) with sensitivity at 95.5% and specificity at 55.9%. Further study in developing stratified norms across different age groups in Chinese-speaking stroke patients is recommended.

  20. The Cambridge Breast Intensity-modulated Radiotherapy Trial: Comparison of Clinician- versus Patient-reported Outcomes.

    Science.gov (United States)

    Mukesh, M B; Qian, W; Wah Hak, C C; Wilkinson, J S; Barnett, G C; Moody, A M; Wilson, C; Coles, C E

    2016-06-01

    Breast radiotherapy-associated toxicity is often reported using clinical and photographic assessments. The addition of patient-reported outcome measures (PROMs) is becoming more common. This study investigated the concordance between clinician- and patient-reported outcomes. The Cambridge Breast Intensity-modulated Radiotherapy (IMRT) trial prospectively collected data on clinician assessment and PROMs at 2 and 5 years after breast radiotherapy. Clinician assessment included physical examination and photographic assessment. PROMs included European Organization for Research and Treatment of Cancer (EORTC) BR23 questionnaire and four breast radiotherapy-specific questions. The correlation between patient and clinician scores were analysed on an independent patient basis using percentage agreement, Cohen's kappa coefficient (k) and Bowker's test of symmetry. The analysis was repeated after stratifying patients based on age, baseline Hospital Anxiety and Depression Score (HADS) and baseline body image score. At 2 and 5 years, a weak level of concordance was seen between the clinician-based assessment and PROMS for all the five toxicity end points (k = 0.05-0.21), with individual patient-based agreement of 32.9-78.3% and a highly discordant Bowker's test of symmetry (P < 0.001). The most frequently reported moderate-severe toxicity by patients was change in breast appearance (14% at both 2 and 5 years), whereas it was breast induration (36% and 25% at 2 and 5 years, respectively) by the clinicians. The lack of concordance was not affected by patient's age, baseline HADS and baseline body image score. This study found that moderate-severe toxicity reported by patients is low and the overall concordance between clinicians and patients is low. This could be due to methodological limitations or alternatively reflects the subjective nature of PROMs. Incorporation of a patient's perception on treatment-related toxicity will have important implications for treatment

  1. Adaptation and Validation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for Use in Spain.

    Science.gov (United States)

    Aguirre-Camacho, Aldo; Stepanous, Jessica; Blanco-Donoso, Luis M; Moreno-Jiménez, Bernardo; Wilburn, Jeanette; González-Saiz, Laura; McKenna, Stephen P

    2017-06-01

    The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is a patient-reported outcome measure of health-related quality of life and quality of life specific to individuals with pulmonary hypertension (PH). This questionnaire has demonstrated superiority over other instruments assessing similar domains. The objective of the present study was to adapt and validate the Spanish version of the questionnaire. The adaptation consisted of 3 stages: translation from English to Spanish using bilingual and lay panels, cognitive debriefing interviews with patients, and assessment of psychometric properties by means of a postal validation survey. The translation panels produced a version of the CAMPHOR that was considered suitable for use by Spanish PH patients. The relevance, comprehensiveness, and acceptability of this version were confirmed in interviews with PH patients. Finally, the validation survey (n = 70) revealed that the 3 CAMPHOR scales (Symptoms, Activities, and Quality of life) showed strong psychometric properties. The internal consistency (Cronbach α) coefficients of the scales were above 0.89, and the test-retest reliability was above 0.87. The convergent and known group validity of the CAMPHOR scales was also demonstrated. The Spanish version of the CAMPHOR is a valid and reliable instrument for the assessment of health-related quality of life and quality of life in Spanish PH patients. Therefore, it is recommended for use in future research and clinical practice in the Spanish population of PH patients. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  2. Hindi translation and validation of Cambridge-Hopkins Diagnostic Questionnaire for RLS (CHRLSq

    Directory of Open Access Journals (Sweden)

    Ravi Gupta

    2015-01-01

    Full Text Available Background: Restless legs syndrome also known as Willis-Ekbom′s Disease (RLS/WED is a common illness. Cambridge-Hopkins diagnostic questionnaire for RLS (CHRLSq is a good diagnostic tool and can be used in the epidemiological studies. However, its Hindi version is not available. Thus, this study was conducted to translate and validate it in the Hindi speaking population. Materials and Methods: After obtaining the permission from the author of the CHRLSq, it was translated into Hindi language by two independent translators. After a series of forward and back translations, the finalized Hindi version was administered to two groups by one of the authors, who were blinded to the clinical diagnosis. First group consisted of RLS/WED patients, where diagnosis was made upon face to face interview and the other group - the control group included subjects with somatic symptoms disorders or exertional myalgia or chronic insomnia. Each group had 30 subjects. Diagnosis made on CHRLSq was compared with the clinical diagnosis. Statistical Analysis: Analysis was done using Statistical Package for Social Sciences (SPSS v 21.0. Descriptive statistics was calculated. Proportions were compared using chi-square test; whereas, categorical variables were compared using independent sample t-test. Sensitivity, specificity, and positive predictive value of the translated version of questionnaire were calculated. Results: Average age was comparable between the cases and control group (RLS/WED = 39.1 ± 10.1 years vs 36.2 ± 11.4 years in controls; P = 0.29. Women outnumbered men in the RLS/WED group (87% in RLS/WED group vs 57% among controls; χ2 = 6.64; P = 0.01. Both the sensitivity and specificity of the translated version was 83.3%. It had the positive predictive value of 86.6%. Conclusion: Hindi version of CHRLSq has positive predictive value of 87% and it can be used to diagnose RLS in Hindi speaking population.

  3. Hindi translation and validation of Cambridge-Hopkins Diagnostic Questionnaire for RLS (CHRLSq).

    Science.gov (United States)

    Gupta, Ravi; Allan, Richard P; Pundeer, Ashwini; Das, Sourav; Dhyani, Mohan; Goel, Deepak

    2015-01-01

    Restless legs syndrome also known as Willis-Ekbom's Disease (RLS/WED) is a common illness. Cambridge-Hopkins diagnostic questionnaire for RLS (CHRLSq) is a good diagnostic tool and can be used in the epidemiological studies. However, its Hindi version is not available. Thus, this study was conducted to translate and validate it in the Hindi speaking population. After obtaining the permission from the author of the CHRLSq, it was translated into Hindi language by two independent translators. After a series of forward and back translations, the finalized Hindi version was administered to two groups by one of the authors, who were blinded to the clinical diagnosis. First group consisted of RLS/WED patients, where diagnosis was made upon face to face interview and the other group - the control group included subjects with somatic symptoms disorders or exertional myalgia or chronic insomnia. Each group had 30 subjects. Diagnosis made on CHRLSq was compared with the clinical diagnosis. Analysis was done using Statistical Package for Social Sciences (SPSS) v 21.0. Descriptive statistics was calculated. Proportions were compared using chi-square test; whereas, categorical variables were compared using independent sample t-test. Sensitivity, specificity, and positive predictive value of the translated version of questionnaire were calculated. Average age was comparable between the cases and control group (RLS/WED = 39.1 ± 10.1 years vs 36.2 ± 11.4 years in controls; P = 0.29). Women outnumbered men in the RLS/WED group (87% in RLS/WED group vs 57% among controls; χ(2) = 6.64; P = 0.01). Both the sensitivity and specificity of the translated version was 83.3%. It had the positive predictive value of 86.6%. Hindi version of CHRLSq has positive predictive value of 87% and it can be used to diagnose RLS in Hindi speaking population.

  4. Measuring impairments in memory and executive function in older people using the Revised Cambridge Cognitive Examination.

    Science.gov (United States)

    Kessels, Roy P C; Mimpen, Gerdy; Melis, René; Rikkert, Marcel G M Olde

    2009-09-01

    The Revised Cambridge Cognitive Examination (CAMCOG-R) is a cognitive screen that has been used to discriminate individuals with dementia from cognitively intact older people. It consists of items assessing various cognitive domains, but the construct validity of the cognitive subscores has not been established yet. The authors examine the subscores Memory and Executive Function in relation to extensive neuropsychological testing in a group of older adults with or without cognitive decline. Observational study. Memory clinic at the department of geriatrics of a university medical center. A convenience sample of 36 outpatients diagnosed with cognitive decline and 24 older healthy participants. Sensitivity and specificity of the CAMCOG-R Memory subscore and Executive Function subscore were established using extensive neuropsychological assessment of memory (using the Rey-Auditory Verbal Learning Test, Location Learning Test, Visual Association Test, and Story Recall) and executive function (using the Brixton Spatial Anticipation Test, Trail Making Test, and Key Search test) as the gold standard. For the CAMCOG-R Executive Function subscore, a cutoff point of 16.5 had a good sensitivity (0.82) and adequate specificity (0.73) for discriminating people with and without executive dysfunction. However, the Total Score and Language subscore also differentiated between people with and without executive dysfunction. The CAMCOG-R Memory subscore could not validly distinguish between people with and without memory impairment. The CAMCOG-R subscores Memory and Executive Function have limited validity, and clinicians should be cautious in interpreting these in the absence of other neuropsychological measures or clinical information.

  5. Evaluation of a brief anti-stigma campaign in Cambridge: do short-term campaigns work?

    Directory of Open Access Journals (Sweden)

    Henderson Claire

    2010-06-01

    Full Text Available Abstract Background In view of the high costs of mass-media campaigns, it is important to understand whether it is possible for a media campaign to have significant population effects over a short period of time. This paper explores this question specifically in reference to stigma and discrimination against people with mental health problems using the Time to Change Cambridge anti-stigma campaign as an example. Methods 410 face-to-face interviews were performed pre, during and post campaign activity to assess campaign awareness and mental health-related knowledge, attitudes and behaviours. Results Although campaign awareness was not sustained following campaign activity, significant and sustained shifts occurred for mental health-related knowledge items. Specifically, there was a 24% (p If a friend had a mental health problem, I know what advice to give them to get professional help, following the campaign. Additionally, for the statement: Medication can be an effective treatment for people with mental health problems, there was a 10% rise (p = 0.05 in the proportion of interviewees responding 'agree' or 'strongly agree' following the campaign. These changes, however, were not evident for attitudinal or behaviour related questions. Conclusions Although these results only reflect the impact of one small scale campaign, these preliminary findings suggest several considerations for mass-media campaign development and evaluation strategies such as: (1 Aiming to influence outcomes pertaining to knowledge in the short term; (2 Planning realistic and targeted outcomes over the short, medium and long term during sustained campaigns; and (3 Monitoring indirect campaign effects such as social discourse or other social networking/contact in the evaluation.

  6. Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999) (book review)

    OpenAIRE

    Peter J. Ramberg

    2000-01-01

    book review of Crawford, Elisabeth: "Arrhenius: From Ionic Theory to the Greenhouse Effect" (Canton 1996); and Diana Barkan: "Walther Nernst and the Transition to Modern Physical Science" (Cambridge 1999)

  7. Book review: Ham radio's technical culture. By K. Haring. Cambridge, MA: The MIT Press. 2007. xvii + 220 pp. #18.95. cloth. ISBN: 0262083558

    OpenAIRE

    Geoghegan, Hilary

    2008-01-01

    Book review: Ham radio's technical culture. By K. Haring. Cambridge, MA: The MIT Press. 2007. xvii + 220 pp. #18.95. cloth. ISBN: 0262083558 Department of Geography Royal Holloway, University of London - (Geoghegan, Hilary)

  8. Cambridge-Cranfield High Performance Computing Facility (HPCF) purchases ten Sun Fire(TM) 15K servers to dramatically increase power of eScience research

    CERN Document Server

    2002-01-01

    "The Cambridge-Cranfield High Performance Computing Facility (HPCF), a collaborative environment for data and numerical intensive computing privately run by the University of Cambridge and Cranfield University, has purchased 10 Sun Fire(TM) 15K servers from Sun Microsystems, Inc.. The total investment, which includes more than $40 million in Sun technology, will dramatically increase the computing power, reliability, availability and scalability of the HPCF" (1 page).

  9. Reliability and validity of the Cambridge Worry Scale in pregnant Turkish women.

    Science.gov (United States)

    Gunay, Emine Yigit; Gul, Asiye

    2015-03-01

    this study examined the psychometric properties of the Cambridge Worry Scale (CWS) and assessed worries in pregnant Turkish women. a descriptive, cross sectional study. the 35 Family Health Centres located in the Yıldırım sub-province of Bursa. the data were collected using the 'Pregnant Information Form', which determines the individual characteristics of the women and the 'CWS', which determines worries. The CWS is a Likert-type scale that consists of 16 items and has four sub-dimensions including the women's own health, relationships, socio-medical and socio-economic conditions. In the CWS, the total score is not calculated, and each article is evaluated in itself. 200 pregnant women were recruited from December 2010 to November 2011. The mean age of the pregnant women was 25.92 ± 5.33, 43.0% had completed primary school, and 69.0% were not in paid employment. It has been determined that the content validity index for the Turkish form is 0.98 and that the internal consistency of Cronbach's alpha value of the scale is 0.795. As a result of exploratory factor analysis, it has been concluded that the factor loadings of the scale from 0.435 to 0.902, and it can be used in a particular dimension that is not divided into the components of the scale. On the basis of the confirmatory factor analysis, it has been determined that the Goodness of Fit Index of the one-factor structure is better than four-factor structure, but the values of the goodness fit index in each model are under 0.85 and the inaccuracy of the fit index is high. the Turkish form of the CWS is an appropriate measurement tool in terms of language and content validity, and its single-factor structure can be applied to Turkish culture and can correctly identify the worries of pregnant women. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Mental health workshops delivered by medical students in Cambridge secondary schools: an evaluation of learning.

    Science.gov (United States)

    Bentham, Chloe; Daunt, Anna; Taylor, Stephanie; Simmons, Meinou

    2013-09-01

    For a group of medical students to design and deliver a mental health workshop in Cambridge secondary schools. Subsequently, to evaluate any improvements in pupils' knowledge of mental health issues, including knowledge of common mental illnesses, stigma and where to access help with mental health problems. A group of three medical students undertook a five week Student Selected Component to develop a mental health workshop in Spring 2013. The workshop was designed to include interactive components, such as role play, models and video. It was delivered to eight classes of 12-13 year old pupils across two local secondary schools, a total of 230 students. Questionnaires were completed before and after each workshop to test knowledge acquisition of mental health issues, stigma and where pupils could get help with mental health problems. Comparisons between data from the pre- and post-workshop questionnaires were made to assess learning. The responses from the questionnaires showed a global improvement in knowledge of mental health. This is highlighted by the increase in awareness of the prevalence of mental health problems amongst young people from 47.0% before the workshops to 97.8% after the workshops. The ability to identify symptoms of anxiety rose from 21.7% to 44.8% and the ability to identify depression rose from 29.0% to 53.5% respectively. Whilst only 15.2% pupils disagreed with a stigmatising statement about mental illness before the workshops, 61.3% pupils disagreed afterwards. The students were also better informed about how to access help and identified areas that they found useful to learn about. Comparison of the pre- and post-workshop questionnaires indicate that medical student-led workshops are an effective method for improving knowledge of mental health topics amongst 12-13 year old school pupils, as well as encouraging positive attitudes towards mental health. The project highlights a demand for mental health education in schools and brings to

  11. The Cambridge Face Memory Test for Children (CFMT-C): a new tool for measuring face recognition skills in childhood.

    Science.gov (United States)

    Croydon, Abigail; Pimperton, Hannah; Ewing, Louise; Duchaine, Brad C; Pellicano, Elizabeth

    2014-09-01

    Face recognition ability follows a lengthy developmental course, not reaching maturity until well into adulthood. Valid and reliable assessments of face recognition memory ability are necessary to examine patterns of ability and disability in face processing, yet there is a dearth of such assessments for children. We modified a well-known test of face memory in adults, the Cambridge Face Memory Test (Duchaine & Nakayama, 2006, Neuropsychologia, 44, 576-585), to make it developmentally appropriate for children. To establish its utility, we administered either the upright or inverted versions of the computerised Cambridge Face Memory Test - Children (CFMT-C) to 401 children aged between 5 and 12 years. Our results show that the CFMT-C is sufficiently sensitive to demonstrate age-related gains in the recognition of unfamiliar upright and inverted faces, does not suffer from ceiling or floor effects, generates robust inversion effects, and is capable of detecting difficulties in face memory in children diagnosed with autism. Together, these findings indicate that the CFMT-C constitutes a new valid assessment tool for children's face recognition skills. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Uma revisão das controvérsias sobre a Equação de Cambridge

    Directory of Open Access Journals (Sweden)

    José Luís Oreiro

    2005-08-01

    Full Text Available The objective of this article is to make a critical evaluation of the controversies about the Cambridge Equation both in the initial phase - when Pasinetti, Kaldor, Meade, Samuelson and Modigliani got involved - and in the second round that followed the publication of Steedman´s article, which contends that the Cambridge Equation still holds even in the case of a balanced government budget. In this setting we will argue that (i the Meade-Samuelson-Modigliani theorem (MSM theorem does not depend on specific hypotheses about the shape of the production function, being fully compatible with the problems of re-switching of techniques raised by the "Capital Controversy", which are only relevant for the stability of the golden-age equilibrium growth path; (ii the Pasinetti-Theorem is, however, more general than the MSM theorem since (a it holds true even after the relaxation of some simplifying hypotheses of its original version, which does not occur with the MSM theorem, and (b Kaldor´s version of the Pasinetti theorem holds true even in the case of the "euthanasia of capitalists".

  13. Hydrologic, Water-Quality, and Meteorological Data for the Cambridge, Massachusetts, Drinking-Water Source Area, Water Year 2005

    Science.gov (United States)

    Smith, Kirk P.

    2007-01-01

    Records of water quantity, water quality, and meteorological parameters were continuously collected from three reservoirs, two primary streams, and four subbasin tributaries in the Cambridge, Massachusetts, drinking-water source area during water year 2005 (October 2004 through September 2005). Water samples were collected during base-flow conditions and storms in the subbasins of the Cambridge Reservoir and Stony Brook Reservoir drainage areas and analyzed for selected elements, organic constituents, suspended sediment, and Escherichia coli bacteria. These data were collected to assist watershed administrators in managing the drinking-water source area and to identify potential sources of contaminants and trends in contaminant loading to the water supply. Monthly reservoir capacities for the Cambridge Reservoir varied from about 59 to 98 percent during water year 2005, while monthly reservoir capacities for the Stony Brook Reservoir and the Fresh Pond Reservoir were maintained at capacities greater than 84 and 96 percent, respectively. Assuming a water demand of 15 million gallons per day by the city of Cambridge, the volume of water released from the Stony Brook Reservoir to the Charles River during the 2005 water year is equivalent to an annual water surplus of about 119 percent. Recorded precipitation in the source area for the 2005 water year was within 2 inches of the total annual precipitation for the previous 2 water years. The monthly mean specific conductances for the outflow of the Cambridge Reservoir were similar to historical monthly mean values. However, monthly mean specific conductances for Stony Brook near Route 20, in Waltham (U.S. Geological Survey station 01104460), which is the principal tributary feeding the Stony Brook Reservoir, were generally higher than the medians of the monthly mean specific conductances for the period of record. Similarly, monthly mean specific conductances for a small tributary to Stony Brook (U.S. Geological Survey

  14. Strategic Research Institute--first international siRNA conference. Prospect for new therapeutics and commercial opportunities for pharma and biotech. 24-25 March 2003, LaJolla, CA, USA.

    Science.gov (United States)

    Xu, Jing

    2003-05-01

    Small interfering RNAs (siRNAs), with their power to selectively silence genes, have gained much attention from biotech and pharmaceutical companies and investors. Key players in the field, from innovative biotech start-ups to big pharmaceutical companies, gathered at Strategic Research Institute's First International siRNA conference in the scenic Hilton La Jolla Torrey Pines. Topics addressed ranged from the latest technology advances and applications of RNA interference (RNAi) in drug discovery, to critical business issues such as intellectual property portfolio strategy and market prospects. While RNAi is indisputably accepted as a powerful tool in target validation and functional genomics, the concept of an siRNA drug is still viewed by big pharma companies as next-generation therapeutics. Yet challenges seem tractable. Several companies, such as Ribozyme Pharmaceuticals Inc, Alnylam Pharmaceuticals and Intradigm Corp, are working hard to prove that the bigger companies are being too conservative. The conference provided a clear vision of RNAi in drug discovery today, its potential and remaining challenges.

  15. Aerial Photography and Imagery, Ortho-Corrected, True Color Orthophotography for Cambridge, Hurlock, Secretary, and Vienna - 4" pixles, 2006., Published in 2006, 1:600 (1in=50ft) scale, Eastern Shore Regional GIS Cooperative.

    Data.gov (United States)

    NSGIC Regional | GIS Inventory — Aerial Photography and Imagery, Ortho-Corrected dataset current as of 2006. True Color Orthophotography for Cambridge, Hurlock, Secretary, and Vienna - 4" pixles,...

  16. Space Biotech: Hindsight, Insight, Foresight

    Science.gov (United States)

    Harper, Lynn

    2015-01-01

    Over the past forty years, microgravity has inspired and enabled applications in a wide range of sectors including medicine, materials, computers, communications, and national defense. Trends show that demand for high-tech solutions is increasing in these sectors, solutions that require higher resolution, greater precision, novel materials, innovative processes, and more sophisticated tools. These are areas where microgravity can offer unique capabilities for innovation. The Emerging Space Office (ESO) has engaged in multiple studies over the past year that have found that microgravity RD is one of the most promising technology areas for contributing to economic growth and to NASAs mission. The focus of these studies was on terrestrial markets rather than NASA applications, applied research rather than basic research, and commercial rather than academic investigators. There have been more success stories than are generally appreciated and there are significant areas of promising future potential. Many of the problems that have limited commercial microgravity development in the past are being solved. Microgravity research and development (RD) requires iteration and learning, as rapidly as possible. New technologies enable high throughput and rapid data collection in increasingly small payloads. The International Space Station is in orbit and provides a laboratory that is available 247 at least until 2024. Frequent flights by commercial space providers to and from the ISS now enable the fast learning cycles needed by high-tech industries. Launch costs are decreasing and the ability to return payloads to Earth is increasing. New commercial space laboratories, such as those being developed by SpaceX and Bigelow Aerospace, are in the final stages of development and testing. This ecosystem for microgravity RD has never been available before. These are game-changer conditions for attracting high-tech industries to space for terrestrial, as well as NASA, applications. However, few know that these capabilities are available or how to use them. In aggregate, the potential value for new applications from microgravity RD over the next ten years could add billions of dollars per year in terrestrial applications to the future economy, create new jobs, and generate a wide range of public benefits in medical advances, while broadening the customer base for the emerging space industry.

  17. Healthy travel and the socio-economic structure of car commuting in Cambridge, UK: A mixed-methods analysis

    Science.gov (United States)

    Goodman, Anna; Guell, Cornelia; Panter, Jenna; Jones, Natalia R.; Ogilvie, David

    2012-01-01

    Car use is associated with substantial health and environmental costs but research in deprived populations indicates that car access may also promote psychosocial well-being within car-oriented environments. This mixed-method (quantitative and qualitative) study examined this issue in a more affluent setting, investigating the socio-economic structure of car commuting in Cambridge, UK. Our analyses involved integrating self-reported questionnaire data from 1142 participants in the Commuting and Health in Cambridge study (collected in 2009) and in-depth interviews with 50 participants (collected 2009–2010). Even in Britain's leading ‘cycling city’, cars were a key resource in bridging the gap between individuals' desires and their circumstances. This applied both to long-term life goals such as home ownership and to shorter-term challenges such as illness. Yet car commuting was also subject to constraints, with rush hour traffic pushing drivers to start work earlier and with restrictions on, or charges for, workplace parking pushing drivers towards multimodal journeys (e.g. driving to a ‘park-and-ride’ site then walking). These patterns of car commuting were socio-economically structured in several ways. First, the gradient of housing costs made living near Cambridge more expensive, affecting who could ‘afford’ to cycle and perhaps making cycling the more salient local marker of Bourdieu's class distinction. Nevertheless, cars were generally affordable in this relatively affluent, highly-educated population, reducing the barrier which distance posed to labour-force participation. Finally, having the option of starting work early required flexible hours, a form of job control which in Britain is more common among higher occupational classes. Following a social model of disability, we conclude that socio-economic advantage can make car-oriented environments less disabling via both greater affluence and greater job control, and in ways manifested across

  18. Healthy travel and the socio-economic structure of car commuting in Cambridge, UK: a mixed-methods analysis.

    Science.gov (United States)

    Goodman, Anna; Guell, Cornelia; Panter, Jenna; Jones, Natalia R; Ogilvie, David

    2012-06-01

    Car use is associated with substantial health and environmental costs but research in deprived populations indicates that car access may also promote psychosocial well-being within car-oriented environments. This mixed-method (quantitative and qualitative) study examined this issue in a more affluent setting, investigating the socio-economic structure of car commuting in Cambridge, UK. Our analyses involved integrating self-reported questionnaire data from 1142 participants in the Commuting and Health in Cambridge study (collected in 2009) and in-depth interviews with 50 participants (collected 2009-2010). Even in Britain's leading 'cycling city', cars were a key resource in bridging the gap between individuals' desires and their circumstances. This applied both to long-term life goals such as home ownership and to shorter-term challenges such as illness. Yet car commuting was also subject to constraints, with rush hour traffic pushing drivers to start work earlier and with restrictions on, or charges for, workplace parking pushing drivers towards multimodal journeys (e.g. driving to a 'park-and-ride' site then walking). These patterns of car commuting were socio-economically structured in several ways. First, the gradient of housing costs made living near Cambridge more expensive, affecting who could 'afford' to cycle and perhaps making cycling the more salient local marker of Bourdieu's class distinction. Nevertheless, cars were generally affordable in this relatively affluent, highly-educated population, reducing the barrier which distance posed to labour-force participation. Finally, having the option of starting work early required flexible hours, a form of job control which in Britain is more common among higher occupational classes. Following a social model of disability, we conclude that socio-economic advantage can make car-oriented environments less disabling via both greater affluence and greater job control, and in ways manifested across the full socio

  19. International Organization of Standardization (ISO) and Cambridge Filter Test (CFT) Smoking Regimen Data Comparisons in Tobacco Product Marketing Applications.

    Science.gov (United States)

    Chae, Changyu; Walters, Matthew J; Holman, Matthew R

    2017-07-01

    We investigated the differences in TNCO (tar, nicotine, and carbon monoxide) smoke yields generated under the International Organization of Standardization (ISO) and Federal Trade Commission (FTC) Cambridge Filter Test (CFT) smoking regimens. Twenty-nine commercial cigarette products from the US marketplace were acquired in 2015 and tested by measuring the TNCO smoke yields generated under these 2 nonintense smoking regimens. Data obtained demonstrated a linear relationship between the TNCO yields produced under the 2 smoking regimens (R 2 > 0.99). TNCO yields produced by each product were higher under the CFT smoking regimen than the ISO smoking regimen. We found that tar, nicotine, and carbon monoxide yields were consistently 10% to 13% higher under the CFT smoking regimen than under the ISO smoking regimen. This strong correlation indicates that the 2 smoking regimens can be used to apply a correlation correction to CFT TNCO data and allow its comparison to ISO TNCO data in tobacco product marketing applications.

  20. Uma revisão das controvérsias sobre a equação de Cambridge

    Directory of Open Access Journals (Sweden)

    José Luís Oreiro

    2009-06-01

    Full Text Available O presente artigo tem por objetivo fazer uma revisão crítica das controvérsias sobre a Equação de Cambridge, tanto na sua fase inicial – na qual se envolveram Pasinetti, Kaldor, Meade, Samuelson e Modigliani – como na fase que se seguiu à publicação do artigo de Steedman, em que se argumenta que a Equação de Cambridge permanece válida mesmo em face da (à introdução de atividades governamentais no modelo básico desenvolvido por Pasinetti. Nesse contexto, procuramos argumentar que (i O “Teorema Meade-Samuelson-Modigliani” (TeoremaMSM não depende de hipóteses específicas sobre o formato da função de produção, sendo plenamente compatível com os problemas de “reversão de técnicas” apontados na “controvérsia do Capital”, os quais só são relevantes para a questão da estabilidade do crescimento em“IdadeDourada” sob o regime Dual ou “Anti-Pasinetti”; (ii O “Teorema de Pasinetti” é, no entanto, mais geral do que o Teorema MSM, uma vez que (a permanece válido mesmo após o relaxamento de algumas hipóteses simplificadoras de sua versão original, o que não ocorre com o Teorema MSM; (b na versão do “Teorema de Pasinetti” feita por Kaldor, o referido teorema permanece válidomesmo no caso de “eutanásia dos capitalistas”, ou seja, nas condições de validade do “Teorema MSM”.

  1. Comparative Coh-Metrix Analysis of Reading Comprehension Texts: Unified (Russian) State Exam in English vs. Cambridge First Certificate in English

    Science.gov (United States)

    Solnyshkina, Marina I.; Harkova, Elena V.; Kiselnikov, Aleksander S.

    2014-01-01

    The article summarizes the results of the comparative study of Reading comprehension texts used in B2 level tests: Unified (Russia) State Exam in English (EGE) and Cambridge First Certificate in English (FCE). The research conducted was mainly focused on six parameters measured with the Coh-Metrix, a computational tool producing indices of the…

  2. The structure of N-arylindazoles and their aza-derivatives in the solid state: A systematic analysis of the Cambridge Structural Database coupled with DFT calculations

    Science.gov (United States)

    Alkorta, Ibon; Elguero, José

    2017-06-01

    A search in the Cambridge Structural Database for N-aryl indazoles and their aza derivatives affords 227 structures (183 1-aryl and 44 2-aryl). To discuss their structures, DFT calculations on 20 model compounds were carried out. The geometry of the five-membered ring (the pyrazole) and the conformation if the N-aryl substituent were analyzed.

  3. Update on the Status of the On-Going Range Dependent Low Frequency Active Sonar Model Benchmarking Effort : From Cambridge to Kos [abstract

    NARCIS (Netherlands)

    Zampolli, M.; Ainslie, M.A.

    2011-01-01

    In April 2010, a symposium in Memory of David Weston was held at Clare College in Cambridge (UK). International researchers from academia and research laboratories met to discuss two sets of test problems for sonar performance models, one aimed at understanding mammal echolocation sonar („Problem

  4. Decline of Executive Function in a Clinical Population: Age, Psychopathology, and Test Performance on the Cambridge Neuropsychological Test Automated Battery (CANTAB)

    NARCIS (Netherlands)

    Janssen, G.T.L.; Aken, L. van; Mey, H.R.A. De; Witteman, C.L.M.; Egger, J.I.M.

    2014-01-01

    This study presents a cross-sectional examination of the age-related executive changes in a sample of adults with a history of psychiatric illness using the Cambridge Neuropsychological Test Automated Battery. A total of 406 patients, aged 18 to 72 years old, completed executive function tests of

  5. Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour Test.

    Science.gov (United States)

    Moura, Ana Laura de Araújo; Teixeira, Rosani Aparecida Antunes; Oiwa, Nestor N; Costa, Marcelo F; Feitosa-Santana, Claudia; Callegaro, Dagoberto; Hamer, Russell D; Ventura, Dora Fix

    2008-01-01

    We assessed chromatic discrimination in multiple sclerosis (MS) patients both with (ON) and without (no ON) a history of optic neuritis using the Cambridge color test (CCT). Our goal was to determine the magnitude and chromatic axes of any color vision losses in both patient groups, and to evaluate age-related changes in chromatic discrimination in both patient groups compared to normals. Using the CCT, we measured chromatic discrimination along the protan, deutan and tritan axes in 35 patients with MS (17 ON eyes) and 74 age matched controls. Color thresholds for both patient groups were significantly higher than controls' along the protan and tritan axes (p color axes (p color discrimination impairment with age (along the deutan and tritan axes) that was almost two times faster than controls, even in the absence of ON. These findings suggest that demyelinating diseases reduce sensitivity to color vision in both red-green and blue-yellow axes, implying impairment in both parvocellular and koniocellular visual pathways. The CCT is a useful tool to help characterize vision losses in MS, and the relationship between these losses and degree of optic nerve involvement.

  6. Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural Database.

    Science.gov (United States)

    Hawkins, Paul C D; Skillman, A Geoffrey; Warren, Gregory L; Ellingson, Benjamin A; Stahl, Matthew T

    2010-04-26

    Here, we present the algorithm and validation for OMEGA, a systematic, knowledge-based conformer generator. The algorithm consists of three phases: assembly of an initial 3D structure from a library of fragments; exhaustive enumeration of all rotatable torsions using values drawn from a knowledge-based list of angles, thereby generating a large set of conformations; and sampling of this set by geometric and energy criteria. Validation of conformer generators like OMEGA has often been undertaken by comparing computed conformer sets to experimental molecular conformations from crystallography, usually from the Protein Databank (PDB). Such an approach is fraught with difficulty due to the systematic problems with small molecule structures in the PDB. Methods are presented to identify a diverse set of small molecule structures from cocomplexes in the PDB that has maximal reliability. A challenging set of 197 high quality, carefully selected ligand structures from well-solved models was obtained using these methods. This set will provide a sound basis for comparison and validation of conformer generators in the future. Validation results from this set are compared to the results using structures of a set of druglike molecules extracted from the Cambridge Structural Database (CSD). OMEGA is found to perform very well in reproducing the crystallographic conformations from both these data sets using two complementary metrics of success.

  7. Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19-20 May 2015.

    Science.gov (United States)

    Spencer, John; Coaker, Hannah

    2015-01-01

    The SelectBio 2015: Academic Drug Discovery Conference was held in Cambridge, UK, on 19-20 May 2015. Building on the success of academic drug discovery events in the USA, this conference aimed to showcase the exciting new research emerging from academic drug discovery and to help bridge the gap between basic research and commercial application. At the event the authors heard from a number of speakers on a broad array of topics, from partnering models for academia and industry to novel drug discovery approaches across various therapeutic areas, with a few talks, such as those by Susanne Muller-Knapp (Structure Genomics Consortium, Oxford University, Oxford, UK) and Julian Blagg (Institute of Cancer Research, UK), covering both remits, by highlighting a number of such partnerships and then delving into some case studies. The conference concluded with a heated debate on whether phenotypic discovery should be favored over targeted discovery in academia and pharma, in a panel discussion chaired by Roland Wolkowicz (San Diego State University, USA).

  8. Robust associations between the 20-item prosopagnosia index and the Cambridge Face Memory Test in the general population.

    Science.gov (United States)

    Gray, Katie L H; Bird, Geoffrey; Cook, Richard

    2017-03-01

    Developmental prosopagnosia (DP) is a neurodevelopmental condition, characterized by lifelong face recognition deficits. Leading research groups diagnose the condition using complementary computer-based tasks and self-report measures. In an attempt to standardize the reporting of self-report evidence, we recently developed the 20-item prosopagnosia index (PI20), a short questionnaire measure of prosopagnosic traits suitable for screening adult samples for DP. Strong correlations between scores on the PI20 and performance on the Cambridge Face Memory Test (CFMT) appeared to confirm that individuals possess sufficient insight into their face recognition ability to complete a self-report measure of prosopagnosic traits. However, the extent to which people have insight into their face recognition abilities remains contentious. A lingering concern is that feedback from formal testing, received prior to administration of the PI20, may have augmented the self-insight of some respondents in the original validation study. To determine whether the significant correlation with the CFMT was an artefact of previously delivered feedback, we sought to replicate the validation study in individuals with no history of formal testing. We report highly significant correlations in two independent samples drawn from the general population, confirming: (i) that a significant relationship exists between PI20 scores and performance on the CFMT, and (ii) that this is not dependent on the inclusion of individuals who have previously received feedback. These findings support the view that people have sufficient insight into their face recognition abilities to complete a self-report measure of prosopagnosic traits.

  9. A teaching skills assessment tool inspired by the Calgary-Cambridge model and the patient-centered approach.

    Science.gov (United States)

    Sommer, Johanna; Lanier, Cédric; Perron, Noelle Junod; Nendaz, Mathieu; Clavet, Diane; Audétat, Marie-Claude

    2016-04-01

    The aim of this study was to develop a descriptive tool for peer review of clinical teaching skills. Two analogies framed our research: (1) between the patient-centered and the learner-centered approach; (2) between the structures of clinical encounters (Calgary-Cambridge communication model) and teaching sessions. During the course of one year, each step of the action research was carried out in collaboration with twelve clinical teachers from an outpatient general internal medicine clinic and with three experts in medical education. The content validation consisted of a literature review, expert opinion and the participatory research process. Interrater reliability was evaluated by three clinical teachers coding thirty audiotaped standardized learner-teacher interactions. This tool contains sixteen items covering the process and content of clinical supervisions. Descriptors define the expected teaching behaviors for three levels of competence. Interrater reliability was significant for eleven items (Kendall's coefficient passessment tool has high reliability and can be used to facilitate the acquisition of teaching skills. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Anion Recognition by Pyrylium Cations and Thio-, Seleno- and Telluro- Analogues: A Combined Theoretical and Cambridge Structural Database Study

    Directory of Open Access Journals (Sweden)

    David Quiñonero

    2015-06-01

    Full Text Available Pyrylium salts are a very important class of organic molecules containing a trivalent oxygen atom in a six-membered aromatic ring. In this manuscript, we report a theoretical study of pyrylium salts and their thio-, seleno- and telluro- analogues by means of DFT calculations. For this purpose, unsubstituted 2,4,6-trimethyl and 2,4,6-triphenyl cations and anions with different morphologies were chosen (Cl–, NO3– and BF4–. The complexes were characterized by means of natural bond orbital and “atoms-in-molecules” theories, and the physical nature of the interactions has been analyzed by means of symmetry-adapted perturbation theory calculations. Our results indicate the presence of anion-π interactions and chalcogen bonds based on both σ- and π-hole interactions and the existence of very favorable σ-complexes, especially for unsubstituted cations. The electrostatic component is dominant in the interactions, although the induction contributions are important, particularly for chloride complexes. The geometrical features of the complexes have been compared with experimental data retrieved from the Cambridge Structural Database.

  11. Applicability of the Calgary-Cambridge Guide to Dog and Cat Owners for Teaching Veterinary Clinical Communications.

    Science.gov (United States)

    Englar, Ryane E; Williams, Melanie; Weingand, Kurt

    2016-01-01

    Effective communication in health care benefits patients. Medical and veterinary schools not only have a responsibility to teach communication skills, the American Veterinary Medical Association (AVMA) Council on Education (COE) requires that communication be taught in all accredited colleges of veterinary medicine. However, the best strategy for designing a communications curriculum is unclear. The Calgary-Cambridge Guide (CCG) is one of many models developed in human medicine as an evidence-based approach to structuring the clinical consultation through 71 communication skills. The model has been revised by Radford et al. (2006) for use in veterinary curricula; however, the best approach for veterinary educators to teach communication remains to be determined. This qualitative study investigated if one adaptation of the CCG currently taught at Midwestern University College of Veterinary Medicine (MWU CVM) fulfills client expectations of what constitutes clinically effective communication. Two focus groups (cat owners and dog owners) were conducted with a total of 13 participants to identify common themes in veterinary communication. Participants compared communication skills they valued to those taught by MWU CVM. The results indicated that while the CCG skills that MWU CVM adopted are applicable to cat and dog owners, they are not comprehensive. Participants expressed the need to expand the skillset to include compassionate transparency and unconditional positive regard. Participants also expressed different communication needs that were attributed to the species of companion animal owned.

  12. Anion Recognition by Pyrylium Cations and Thio-, Seleno- and Telluro- Analogues: A Combined Theoretical and Cambridge Structural Database Study.

    Science.gov (United States)

    Quiñonero, David

    2015-06-24

    Pyrylium salts are a very important class of organic molecules containing a trivalent oxygen atom in a six-membered aromatic ring. In this manuscript, we report a theoretical study of pyrylium salts and their thio-, seleno- and telluro- analogues by means of DFT calculations. For this purpose, unsubstituted 2,4,6-trimethyl and 2,4,6-triphenyl cations and anions with different morphologies were chosen (Cl-, NO3- and BF4-). The complexes were characterized by means of natural bond orbital and "atoms-in-molecules" theories, and the physical nature of the interactions has been analyzed by means of symmetry-adapted perturbation theory calculations. Our results indicate the presence of anion-π interactions and chalcogen bonds based on both σ- and π-hole interactions and the existence of very favorable σ-complexes, especially for unsubstituted cations. The electrostatic component is dominant in the interactions, although the induction contributions are important, particularly for chloride complexes. The geometrical features of the complexes have been compared with experimental data retrieved from the Cambridge Structural Database.

  13. Hukum Lingkungan dan Pertanggungjawaban Strict Liability dalam Sistem Hukum Common Law (Studi Kasus Cambridge Water Co. Ltd v. Eastern Countries Leather Plc

    Directory of Open Access Journals (Sweden)

    Mahfud Mahfud

    2010-12-01

    Full Text Available ABSTRACT: The possibilities for pollution control still offered today Blackburn J.’s celebrated rule of strict liability, now almost 130 years old, has ensured its continuing popularity. There can be few tort lawyers, however, who have not increasingly wondered how much time should be devoted to a case which has received little judicial attention in recent years, and which was last subjected to detailed consideration by the House of Lords nearly 50 years ago, until, that is, the much-published decision of the House of Lords in Cambridge Water Co. Ltd v. Eastern Countries Leather Plc.   (Environmental Law and The Strict Liability Application In the Common Law System (The Case Study of Cambridge Water Co. Ltd V. Eastern Countries Leather Plc

  14. Reply to L.M. Brown et al. “Brief history of the Cambridge STEM aberration correction project and its progeny” in Ultramicroscopy 157, 88 (2015)

    Energy Technology Data Exchange (ETDEWEB)

    Urban, K.W., E-mail: k.urban@fz-juelich.de [Peter Grünberg Institute, Forschungszentrum Jülich, Jülich-Aachen Research Alliance (JARA), and Ernst Ruska Centre for Microscopy and Spectroscopy with Electrons, 52425 Jülich (Germany); Rose, H. [Materialwissenschaftliche Elektronenmikroskopie, Universität Ulm, Albert-Einstein-Allee 11, 89081 Ulm (Germany)

    2016-02-15

    We comment on a Short Communication recently published in Ultramicroscopy in which Brown et al. criticize our description of the time sequence of events in the development of aberration correction systems in electron optics during the 1990s put forward in the introduction to the Ultramicroscopy April 2015 Special Issue. We present an analysis of the published literature furnishing evidence that our description is correct. - Highlights: • We scrutinize assertions made on the evolution of Cambridge Cs corrector project. • References [22-24] do not demonstrate improvement of resolution by Cs correction. • According to literature such improvement is only shown in reference [10] in 2001. • Corresponding evidence was published by Heidelberg project already in 1998. • The Heidelberg Cs corrector project antedates the Cambridge project by 3 years.

  15. Surface-water, water-quality, and meteorological data for the Cambridge, Massachusetts, drinking-water source area, water years 2007-08

    Science.gov (United States)

    Smith, Kirk P.

    2011-01-01

    Records of water quantity, water quality, and meteorological parameters were continuously collected from three reservoirs, two primary streams, and five subbasin tributaries in the Cambridge, Massachusetts, drinking-water source area during water years 2007-08 (October 2006 through September 2008). Water samples were collected during base-flow conditions and storms in the Cambridge Reservoir and Stony Brook Reservoir drainage areas and analyzed for dissolved calcium, sodium, chloride, and sulfate; total nitrogen and phosphorus; and polar pesticides and metabolites. Composite samples of stormwater also were analyzed for concentrations of total petroleum hydrocarbons and suspended sediment in one subbasin in the Stony Brook Reservoir drainage basin. These data were collected to assist watershed administrators in managing the drinking-water source area and to identify potential sources of contaminants and trends in contaminant loading to the water supply.

  16. Book review: Ham radio's technical culture. By K. Haring. Cambridge, MA: The MIT Press. 2007. xvii + 220 pp. £18.95. cloth. ISBN: 0262083558

    OpenAIRE

    Geoghegan, Hilary

    2008-01-01

    284 Book reviewHam radio's technical culture. By K. Haring. Cambridge, MA: The MIT Press. 2007. xvii + 220 pp. £18.95. cloth. ISBN: 0262083558 SAGE Publications, Inc.2008DOI: 10.1177/14744740080150020805 HilaryGeoghegan Department of Geography Royal Holloway, University of London `G4PDH, G4PDH, this is 2M1QQQ calling you. How do you copy?' Music to the amateur radio enthusiast's ears. Radio hams are the subject of Kristen Haring's enjoyab...

  17. Factor V Leiden, factor V Cambridge, factor II GA20210, and methylenetetrahydrofolate reductase in cerebral venous and sinus thrombosis: A case-control study.

    Science.gov (United States)

    Saadatnia, Mohammad; Salehi, Mansour; Movahedian, Ahmad; Shariat, Seyed Ziaeddin Samsam; Salari, Mehri; Tajmirriahi, Marzieh; Asadimobarakeh, Elham; Salehi, Rasoul; Amini, Gilda; Ebrahimi, Homa; Kheradmand, Ehsan

    2015-06-01

    Factor V G1691A (FV Leiden), FII GA20210, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are the most common genetic risk factors for thromboembolism in the Western countries. However, there is rare data in Iran about cerebral venous and sinus thrombosis (CVST) patients. The aim of this study was to evaluate the frequency of common genetic thrombophilic factors in CVST patients. Forty consequently CVST patients from two University Hospital in Isfahan University of Medical Sciences aged more than 15 years from January 2009 to January 2011 were recruited. In parallel, 51 healthy subjects with the same age and race from similar population selected as controls. FV Leiden, FII GA20210, MTHFR C677T, and FV Cambridge gene mutations by polymerase chain reaction technique were evaluated in case and control groups. FV Leiden, FII GA20210, and FV Cambridge gene mutations had very low prevalence in both case (5%, 2%, 0%) and control (2.5%, 0%, 0%) and were not found any significant difference between groups. MTHFR C677T mutations was in 22 (55%) of patients in case group and 18 (35.5%) of control group (P = 0.09). This study showed that the prevalence of FV Leiden, FII GA20210, and FV Cambridge were low. Laboratory investigations of these mutations as a routine test for all patients with CVST may not be cost benefit.

  18. EDITORIAL: Proceedings of the 12th Gravitational Wave Data Analysis Workshop (GWDAW 12), Cambridge, MA, USA, 13 16 December 2007

    Science.gov (United States)

    Hughes, S.; Katsavounidis, E.

    2008-09-01

    It was a great pleasure and an honor for us to host the 12th Gravitational Wave Data Analysis Workshop (GWDAW) at MIT and the LIGO Laboratory in Cambridge, Massachusetts, the place where this workshop series started in 1996. This time the conference was held at the conference facilities of the Royal Sonesta Hotel in Cambridge from 13 16 December, 2007. This 12th GWDAW found us with the ground interferometers having just completed their most sensitive search for gravitational waves and as they were starting their preparation to bring online and/or propose more sensitive instruments. Resonant mass detectors continued to observe the gravitational wave sky with instruments that have been operating now for many years. LISA, the Laser Interferometer Space Antenna, was recently reviewed by NASA's Beyond Einstein Program Assessment Committee (BEPAC) convened by the National Research Council (NRC) and found that 'on purely scientific grounds LISA is the mission that is the most promising and least scientifically risky…thus, the committee gave LISA its highest scientific ranking'. Even so, JDEM, the Joint Dark Energy Mission, was identified to go first, with LISA following a few years after. New methods, analysis ideas, results from the analysis of data collected by the instruments, as well as Mock Data Challenges for LISA were reported in this conference. While data from the most recent runs of the instruments are still being analyzed, the first upper limit results show how even non-detection statements can be interesting astrophysics. Beyond these traditional aspects of GWDAW though, for the first time in this workshop we tried to bring the non-gravitational wave physics and astronomy community on board in order to present, discuss and propose ways to work together as we pursue the first detection of gravitational waves and as we hope to transition to gravitational wave astronomy in the near future. Overview talks by colleagues leading observations in the electromagnetic

  19. Adaptation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) into French-Canadian and English-Canadian.

    Science.gov (United States)

    Coffin, Donna; Duval, Karine; Martel, Simon; Granton, John; Lefebvre, Marie-Claude; Meads, David M; Twiss, James; McKenna, Stephen P

    2008-03-01

    The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is the first disease-specific instrument for assessing patient-reported symptoms, functioning and quality of life (QoL) in pulmonary arterial hypertension (PAH). To create and validate French-Canadian (FC) and English-Canadian (EC) language versions of the CAMPHOR. A translation panel (for the FC version) and lay panels (for both versions) were convened to adapt the questionnaires (dual-panel methodology). Subsequently, these new questionnaires were field-tested in 15 FC PAH and 15 EC PAH patients. Finally, in a postal validation study, the new language versions of the CAMPHOR underwent psychometric evaluation in 41 FC and 52 EC PAH patients to test for reliability and validity. The FC and EC field-test interview participants found the questionnaires relevant, comprehensible and easy to complete. Psychometric analyses showed that the FC and EC adaptations were successful. High test-retest coefficients for the scales after controlling for change in respondent's QoL (FC: 0.92 to 0.96; EC: 0.85 to 0.99) indicated a high degree of reliability. The FC and EC CAMPHOR scales had good internal consistency (Cronbach's alpha coefficients 0.90 to 0.92 and 0.88 to 0.92, respectively). Predicted correlations with the Nottingham Health Profile provided evidence of the construct validity of the FC and EC scales. The FC and EC adaptations also showed known groups validity. The FC and EC adaptations of the CAMPHOR have been shown to be reliable and valid for measures of health-related QoL and QoL in PAH, and thus can be recommended for use in clinical studies and routine practice in PAH.

  20. Color vision impairment in type 2 diabetes assessed by the D-15d test and the Cambridge Colour Test.

    Science.gov (United States)

    Feitosa-Santana, Claudia; Paramei, Galina V; Nishi, Mauro; Gualtieri, Mirella; Costa, Marcelo F; Ventura, Dora F

    2010-09-01

    Color vision impairment emerges at early stages of diabetes mellitus type 2 (DM2) and may precede diabetic retinopathy or the appearance of vascular alterations in the retina. The aim of the present study was to compare the evaluation of the color vision with two different tests - the Lanthony desaturated D-15d test (a traditional color arrangement test), and the Cambridge Colour Test (CCT) (a computerized color discrimination test) - in patients diagnosed with DM2 without clinical signs of diabetic retinopathy (DR), and in sex- and age-matched control groups. Both color tests revealed statistically significant differences between the controls and the worst eyes of the DM2 patients. In addition, the degree of color vision impairment diagnosed by both tests correlated with the disease duration. The D-15d outcomes indicated solely tritan losses. In comparison, CCT outcomes revealed diffuse losses in color discrimination: 13.3% for best eyes and 29% for worst eyes. In addition, elevation of tritan thresholds in the DM2 patients, as detected by the Trivector subtest of the CCT, was found to correlate with the level of glycated hemoglobin. Outcomes of both tests confirm that subclinical losses of color vision are present in DM2 patients at an early stage of the disease, prior to signs of retinopathy. Considering the advantages of the CCT test compared to the D-15d test, further studies should attempt to verify and/or improve the efficiency of the CCT test. © 2010 The Authors, Ophthalmic and Physiological Optics © 2010 The College of Optometrists.

  1. Risk factors for dating violence versus cohabiting violence: Results from the third generation of the Cambridge Study in Delinquent Development.

    Science.gov (United States)

    Theobald, Delphine; Farrington, David P; Ttofi, Maria M; Crago, Rebecca V

    2016-10-01

    Dating violence is an important problem. Evidence suggests that women are more likely to perpetrate dating violence. The present study investigates the prevalence of dating violence compared with cohabiting violence in a community sample of men and women and assesses to what extent child and adolescent explanatory factors predict this behaviour. A secondary aim is to construct a risk score for dating violence based on the strongest risk factors. The Cambridge Study in Delinquent Development is a prospective longitudinal survey of 411 men (generation 2) born in the 1950s in an inner London area. Most recently, their sons and daughters [generation 3 (G3)] have been interviewed regarding their perpetration of dating and cohabiting violence, utilising the Conflict Tactics Scale. Risk factors were measured in four domains (family, parental, socio-economic and individual). A larger proportion of women than men perpetrated at least one act of violence towards their dating partner (36.4 vs 21.7%). There was a similar pattern for cohabiting violence (39.6 vs 21.4%). A number of risk factors were significantly associated with the perpetration of dating violence. For G3 women, these included a convicted father, parental conflict, large family size and poor housing. For G3 men, these included having a young father or mother, separation from the father before age 16, early school leaving, frequent truancy and having a criminal conviction. A risk score for both men and women, based on 10 risk factors, significantly predicted dating violence. Risk factors from four domains were important in predicting dating violence, but they were different for G3 men and women. It may be important to consider different risk factors and different risk assessments for male compared with female perpetration of dating violence. Early identification and interventions are recommended. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Reliability and validity of a Japanese version of the Cambridge depersonalization scale as a screening instrument for depersonalization disorder.

    Science.gov (United States)

    Sugiura, Miyuki; Hirosawa, Masataka; Tanaka, Sumio; Nishi, Yasunobu; Yamada, Yasuyuki; Mizuno, Motoki

    2009-06-01

    The Cambridge Depersonalization Scale (CDS) is an instrument that has obtained reliability and validity in some countries for use in detecting depersonalization disorder under clinical conditions, but not yet in Japan under non-psychiatric conditions. The purposes of this study were to develop a Japanese version of the CDS (J-CDS) and to examine its reliability and validity as an instrument for screening depersonalization disorder under non-clinical conditions. The CDS was translated from English into Japanese and then back-translated into English by a native English-speaking American. After making the J-CDS, we examined its reliability and validity. Questionnaires that were composed of J-CDS, the Dissociative Experience Scale (DES), the Zung self-rating scale and the Maudsley Obsessional-Compulsive Inventory were administrated to 59 participants (12 patients with depersonalization disorder, 11 individuals who had recovered from depersonalization and 36 healthy controls). Cronbach's alpha and split-half reliability were 0.94 and 0.93, respectively. The J-CDS score in the depersonalization group was significantly higher than in the healthy control group. The J-CDS score was significantly correlated with scores of total DES, and DES-depersonalization. The best compromise between the true positive and false negative rate was at a cut-off point of 60, yielding a sensitivity of 1.00 and a specificity of 0.96. In this study, J-CDS showed good reliability and validity. The best cut-off point, when we use this for distinguishing individuals with depersonalization disorder from individuals without psychiatric disorders, is 60 points.

  3. Multiphase composition changes and reactive oxygen species formation during limonene oxidation in the new Cambridge Atmospheric Simulation Chamber (CASC)

    Science.gov (United States)

    Gallimore, Peter J.; Mahon, Brendan M.; Wragg, Francis P. H.; Fuller, Stephen J.; Giorio, Chiara; Kourtchev, Ivan; Kalberer, Markus

    2017-08-01

    The chemical composition of organic aerosols influences their impacts on human health and the climate system. Aerosol formation from gas-to-particle conversion and in-particle reaction was studied for the oxidation of limonene in a new facility, the Cambridge Atmospheric Simulation Chamber (CASC). Health-relevant oxidising organic species produced during secondary organic aerosol (SOA) formation were quantified in real time using an Online Particle-bound Reactive Oxygen Species Instrument (OPROSI). Two categories of reactive oxygen species (ROS) were identified based on time series analysis: a short-lived component produced during precursor ozonolysis with a lifetime of the order of minutes, and a stable component that was long-lived on the experiment timescale (˜ 4 h). Individual organic species were monitored continuously over this time using Extractive Electrospray Ionisation (EESI) Mass Spectrometry (MS) for the particle phase and Proton Transfer Reaction (PTR) MS for the gas phase. Many first-generation oxidation products are unsaturated, and we observed multiphase aging via further ozonolysis reactions. Volatile products such as C9H14O (limonaketone) and C10H16O2 (limonaldehyde) were observed in the gas phase early in the experiment, before reacting again with ozone. Loss of C10H16O4 (7-hydroxy limononic acid) from the particle phase was surprisingly slow. A combination of reduced C = C reactivity and viscous particle formation (relative to other SOA systems) may explain this, and both scenarios were tested in the Pretty Good Aerosol Model (PG-AM). A range of characterisation measurements were also carried out to benchmark the chamber against existing facilities. This work demonstrates the utility of CASC, particularly for understanding the reactivity and health-relevant properties of organic aerosols using novel, highly time-resolved techniques.

  4. Healthy Behaviour Change and Cardiovascular Outcomes in Newly Diagnosed Type 2 Diabetes Patients - ADDITION-Cambridge Cohort Study

    Science.gov (United States)

    Long, Gráinne H; Cooper, Andrew J M; Wareham, Nicholas J; Griffin, Simon J; Simmons, Rebecca K

    2014-01-01

    OBJECTIVE To examine whether improvements in health behaviours are associated with reduced risk of cardiovascular disease (CVD) in individuals with newly-diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS Population-based prospective cohort study of 867 newly diagnosed diabetes patients aged between 40 and 69 years from the treatment phase of the ADDITION-Cambridge study. As the results for all analyses were similar by trial arm, data were pooled and results presented for the whole cohort. Participants were identified via population-based stepwise screening between 2002 and 2006 and underwent assessment of physical activity (EPAQ questionnaire), diet (plasma vitamin C and self-report), and alcohol consumption (self-report) at baseline and one year. A composite primary CVD outcome was examined, comprised of cardiovascular mortality, non-fatal myocardial infarction, nonfatal stroke and revascularisation. RESULTS After a mean (SD) follow-up of 5.1 (1.1) years, 6% of the cohort experienced a CVD event (12.2/1000-person years; 95% CI 9.3 to 15.9). CVD risk was inversely related to the number of positive health behaviours changed in the year following diabetes diagnosis. The relative risk (95% CI) for primary CVD event in individuals who did not change any health behavior compared to those who adopted three/four healthy behaviors was 4.17 (1.02 to 17.09), adjusting for age, sex, study group, social class occupation and prescription of cardio-protective medication (ptrend = 0.005). CONCLUSIONS Cardiovascular disease risk was inversely associated with the number of healthy behaviour changes adopted in the year following diagnosis of diabetes. Interventions that promote early achievement of these goals in newly diagnosed patients could help reduce the burden of diabetes-related morbidity and mortality. PMID:24658389

  5. Vivienda, en Cambridge

    Directory of Open Access Journals (Sweden)

    Sert, José Luis

    1960-05-01

    Full Text Available La casa de un arquitecto expresa siempre, sin traba alguna, su modo de ver y sentir la arquitectura, y la que hoy exponemos, residencia de su propio autor, recuerda vivamente un concepto de intimidad —inspirado tal vez en la tradición árabe, tan arraigada en gran parte de España, patria del autor—, un ponderado amor a la sencillez de líneas, luminosidad y viveza de color.

  6. Potential reductions of street solids and phosphorus in urban watersheds from street cleaning, Cambridge, Massachusetts, 2009-11

    Science.gov (United States)

    Sorenson, Jason R.

    2013-01-01

    Material accumulating and washing off urban street surfaces and ultimately into stormwater drainage systems represents a substantial nonpoint source of solids, phosphorus, and other constituent loading to waterways in urban areas. Cost and lack of usable space limit the type and number of structural stormwater source controls available to municipalities and other public managers. Non-structural source controls such as street cleaning are commonly used by cities and towns for construction, maintenance and aesthetics, and may reduce contaminant loading to waterways. Effectiveness of street cleaning is highly variable and potential improvements to water quality are not fully understood. In 2009, the U.S. Geological Survey, in cooperation with the Massachusetts Department of Environmental Protection, the U.S. Environmental Protection Agency, and the city of Cambridge, Massachusetts, and initiated a study to better understand the physical and chemical nature of the organic and inorganic solid material on street surfaces, evaluate the performance of a street cleaner at removing street solids, and make use of the Source Loading and Management Model (SLAMM) to estimate potential reductions in solid and phosphorus loading to the lower Charles River from various street-cleaning technologies and frequencies. Average yield of material on streets collected between May and December 2010, was determined to be about 740 pounds per curb-mile on streets in multifamily land use and about 522 pounds per curb-mile on commercial land-use streets. At the end-of-winter in March 2011, about 2,609 and 4,788 pounds per curb-mile on average were collected from streets in multifamily and commercial land-use types, respectively. About 86 percent of the total street-solid yield from multifamily and commercial land-use streets was greater than or equal to 0.125 millimeters in diameter (or very fine sand). Observations of street-solid distribution across the entire street width indicated that as

  7. Loads and yields of deicing compounds and total phosphorus in the Cambridge drinking-water source area, Massachusetts, water years 2009–15

    Science.gov (United States)

    Smith, Kirk P.

    2017-09-12

    The source water area for the drinking-water supply of the city of Cambridge, Massachusetts, encompasses major transportation corridors, as well as large areas of light industrial, commercial, and residential land use. Because of the large amount of roadway in the drinking-water source area, the Cambridge water supply is affected by the usage of deicing compounds and by other constituents that are flushed from such impervious areas. The U.S. Geological Survey (USGS) has monitored surface-water quality in the Cambridge Reservoir and Stony Brook Reservoir Basins, which compose the drinking-water source area, since 1997 (water year 1998) through continuous monitoring and the collection of stream-flow samples.In a study conducted by the USGS, in cooperation with the City of Cambridge Water Department, concentrations and loads of calcium (Ca), chloride (Cl), magnesium (Mg), sodium (Na), and sulfate (SO4) were estimated from continuous records of specific conductance and streamflow for streams and tributaries at 10 continuous water-quality monitoring stations. These data were used to characterize current (2015) water-quality conditions, estimate loads and yields, and describe trends in Cl and Na in the tributaries and main-stem streams in the Cambridge Reservoir and Stony Brook Reservoir Basins. These data also were used to describe how stream-water quality is related to various basin characteristics and provide information to guide future management of the drinking-water source area.Water samples from 2009–15 were analyzed for physical properties and concentrations of Ca, Cl, Mg, Na, potassium (K), SO4, and total phosphorus (TP). Values of physical properties and constituent concentrations varied widely, particularly in composite samples of stormflow from tributaries that have high percentages of constructed impervious areas. Median concentrations of Ca, Cl, Mg, Na, and K in samples collected from the tributaries in the Cambridge Reservoir Basin (27.2, 273, 4.7, 154

  8. Nitroxide stable radicals interacting as Lewis bases in hydrogen bonds: A search in the Cambridge structural data base for intermolecular contacts

    Science.gov (United States)

    Alkorta, Ibon; Elguero, José; Elguero, Eric

    2017-11-01

    1125 X-ray structures of nitroxide free radicals presenting intermolecular hydrogen bonds have been reported in the Cambridge Structural Database. We will report in this paper a qualitative and quantitative analysis of these bonds. The observation in some plots of an excluded region was statistically analyzed using convex hull and kernel smooting methodologies. A theoretical study at the MP2 level with different basis has been carried out indicating that the nitronyl nitroxide radicals (five electrons) lie just in between nitroso compounds (four electrons) and amine N-oxides (six electrons) as far as hydrogen-bond basicity is concerned.

  9. A preliminary validity study of the cambridge neuropsychological test automated battery for the assessment of executive function in schizophrenia and bipolar disorder.

    Science.gov (United States)

    Kim, Hee Sun; An, Yong Min; Kwon, Jun Soo; Shin, Min-Sup

    2014-10-01

    Although the executive function subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) have been used to assess cognitive function in diverse psychiatric illnesses, few studies have verified the validity of this battery for Korean psychiatric patients. Therefore, this preliminary study evaluated the construct and concurrent validity of the executive function subtests of the CANTAB for Korean psychiatric patients by comparing it with subtests of the Computerized Neuropsychological Test (CNT). Three subtests of the CANTAB and three subtests of the CNT were administered to 36 patients diagnosed with either schizophrenia or bipolar disorder. Subtests of the CANTAB included the Intra/Extra-Dimensional Set Shift (IED), Stockings of Cambridge (SOC), and Spatial Working Memory (SWM). Differences between groups on each subtest as well as correlations between the subtests of the CANTAB and the CNT were assessed. The schizophrenia group performed significantly more poorly on the IED and the Wisconsin Card Sorting Test (WCST) compared with the bipolar disorder group. Additionally, correlation analyses revealed a significant correlation between the IED and the WCST; a positive correlation between the SOC and the Trail Making Test, Part B and the Stroop test; and a significant correlation between the SWM and the Stroop test. This study verified the construct and concurrent validity of the executive function subtests of the CANTAB for Korean psychiatric patients and suggests that the subtests of this battery would be useful and appropriate for assessing deficits in executive function in Korean clinical settings.

  10. The Cambridge Bachelor of Medicine (MB)/Doctor of Philosophy (PhD): graduate outcomes of the first MB/PhD programme in the UK.

    Science.gov (United States)

    Cox, Timothy M; Brimicombe, James; Wood, Diana F; Peters, D Keith

    2012-12-01

    We reviewed outcomes of the Cambridge Bachelor of Medicine (MB)/Doctor of Philosophy (PhD) programme for the period 1989-2010. Of the 90 alumni contacted, 80 (89%; 24 women) completed an anonymous questionnaire. Thirty were academic staff and 35 were in general professional (core) or higher medical training. Of the latter, 11 were specialty registrars, six were academic clinical fellows and three held academic foundation year posts. Eight alumni were overseas, including five in North America. Most (95%) respondents considered that their academic career goals were facilitated by the programme. Sixty-eight of the 80 alumni had conducted further research, 63 (79%) were active in research, and 90% had explicit plans for further full-time research. Twelve graduates had further substantive research support (six clinician scientist awards and three senior fellowships) and two were Wellcome Trust postdoctoral MB/PhD fellows. Alumni included two full university professors, one reader, six senior lecturers, two assistant professors and nine university clinical lecturers. MB/PhD programmes offer an alternative training pathway for clinician-scientists in UK medical schools: the Cambridge programme promotes scientific discovery and sustained academic development within the context of contemporary medicine and clinical practice.

  11. 40-Godišnjica institucije Cambridge Crystallographic Data Centre posvećene pohranjivanju podataka o molekularnim i kristalnim strukturama -

    Directory of Open Access Journals (Sweden)

    Molčanov, K.

    2006-06-01

    Full Text Available The article is dedicated to 40th anniversary of The Cambridge Crystallographic Data Centre (CCDC, the world-known centre (http://www.ccdc.cam.ac.uk responsible for deposition and control of crystallographic data, including atomic coordinates that define the three-dimensional structures of organic molecules and metal complexes containing organic ligands. Cambride Structural Database (CSD, one among the first established electronic databases, nowadays is the most significant crystallographic database in the world. CSD has about 400,000 deposited structures. The use of the extensive database, which is growing rapidly, needs support of efficient and sophisticated software for searching, analysing and visualising structural data. The seminal role of CSD in the research related to crystallography, chemistry, material sciences, solid state physics and chemistry, life sciences, pharmacology, and in particular in drug design, has been documented in more than 1300 scientific papers. The important issues of CCDC are the accuracy of deposited data and development of software that enables a wide variety of applications. Such demanding project requires higly competent team of experts; thus the article brings into focus the scientific approach of the team based on the long tradition in crystallography, modelling and informatics. The article is not dedicated to 40th anniversary of the centre only, but it also reveals how Cambridge Structural Database can be used in the research and teaching. The use of electronic media and computer graphics makes “data mining" very efficient and useful but also esthetically appealing due to the molecular architecture. At the Rudjer Bošković Institute, Zagreb, Croatia there is The National Affiliated Centre of Cambridge Crystallographic Data Centre responsible for communication and dissemination of CSD in Croatia, Slovenia and Macedonia. The use of CSD is illustrated by two examples performed and published by the presenting

  12. The ADDITION-Cambridge trial protocol: a cluster – randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients

    Science.gov (United States)

    Echouffo-Tcheugui, Justin B; Simmons, Rebecca K; Williams, Kate M; Barling, Roslyn S; Prevost, A Toby; Kinmonth, Ann Louise; Wareham, Nicholas J; Griffin, Simon J

    2009-01-01

    Background The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain. Methods and design The ADDITION-Cambridge study aims to evaluate the effectiveness and cost-effectiveness of (i) a stepwise screening strategy for type 2 diabetes; and (ii) intensive multifactorial treatment for people with screen-detected diabetes in primary care. 63 practices in the East Anglia region participated. Three undertook the pilot study, 33 were allocated to three groups: no screening (control), screening followed by intensive treatment (IT) and screening plus routine care (RC) in an unbalanced (1:3:3) randomisation. The remaining 27 practices were randomly allocated to IT and RC. A risk score incorporating routine practice data was used to identify people aged 40–69 years at high-risk of undiagnosed diabetes. In the screening practices, high-risk individuals were invited to take part in a stepwise screening programme. In the IT group, diabetes treatment is optimised through guidelines, target-led multifactorial treatment, audit, feedback, and academic detailing for practice teams, alongside provision of educational materials for newly diagnosed participants. Primary endpoints are modelled cardiovascular risk at one year, and cardiovascular mortality and morbidity at five years after diagnosis of diabetes. Secondary endpoints include all-cause mortality, development of renal and visual impairment, peripheral neuropathy, health service costs, self-reported quality of life, functional status and health utility. Impact of the screening programme at the population level is also assessed through measures of mortality, cardiovascular morbidity, health status and health service use among high-risk individuals. Discussion ADDITION-Cambridge is conducted in a defined high-risk group accessible through primary

  13. Cambridge Neuropsychological Test Automated Battery in assessment of cognitive parameters in patients with systemic lupus erythematosus in relation to autoantibody profile.

    Science.gov (United States)

    Bogaczewicz, Anna; Sobow, Tomasz; Kowalski, Jan; Ząbek, Jakub; Woźniacka, Anna; Bogaczewicz, Jaroslaw

    2015-01-01

    To relate the cognitive parameters of systemic lupus erythematosus (SLE) patients in remission to their profile of autoantibodies. The study included 32 patients with SLE in remission, with mild disease activity as indicated by SELENA-SLEDAI Cambridge Neuropsychological Test Automated Battery (CANTAB) was applied, using motor screening (MOT), big little circle (BLC), paired associated learning (PAL), stockings of Cambridge (SOC), and graded naming tests (GNT). Detection of autoantibodies against dsDNA, nucleosome (aNuc), Sm, and anticardiolipin (aCL: IgG and IgM) was performed with immunoassays. The SLE patients demonstrated standard scores below norms, matched according to age and gender, in the following tests: GNT (-0.87 ±0.85), SOC PSMM (-0.47 ±0.97), PAL (-1.88 ±3.58), and BLC (-0.31 ±1.90). GNT scores under -0.5 were found significantly more frequently in SLE patients, seen in roughly 66% of test subjects. Values for PAL and mean subsequent thinking time of stockings of Cambridge (SOC MSTT) were found to be lower than -0.5 in approximately half of the patients. Mean error of motor screening (MOT ME) was found to negatively correlate with mean latency of motor screening (MOT ML) (r = -0.55). PAL significantly correlated with SOC MSTT (r = 0.38) and with GNT (r = 0.36). Anti-dsDNA antibody level correlated negatively with MOT ME (r = -0.46). Anti-Nuc antibodies correlated with MOT ML (r = 0.41) but negatively correlated with MOT ME (r = -0.58). The levels of anti-Sm, anti-CL IgM and IgG did not correlate significantly with the outcomes of CANTAB. The age of the patients correlated negatively with MOT ME (r = -0.36), positively with BLC (r = 0.53) and negatively with SOC MSTT (r = -0.43). The level of anti-Nuc antibodies correlated with anti-dsDNA level (r = 0.62) and of anti-CL IgM with anti-Sm (r = 0.39) and anti-CL IgG (r = 0.87). CANTAB reveals a decrease in selected cognitive functions in patients with SLE. ACL IgG and anti-dsDNA antibodies indicated

  14. The ADDITION-Cambridge trial protocol: a cluster – randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients

    Directory of Open Access Journals (Sweden)

    Kinmonth Ann

    2009-05-01

    Full Text Available Abstract Background The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain. Methods and design The ADDITION-Cambridge study aims to evaluate the effectiveness and cost-effectiveness of (i a stepwise screening strategy for type 2 diabetes; and (ii intensive multifactorial treatment for people with screen-detected diabetes in primary care. 63 practices in the East Anglia region participated. Three undertook the pilot study, 33 were allocated to three groups: no screening (control, screening followed by intensive treatment (IT and screening plus routine care (RC in an unbalanced (1:3:3 randomisation. The remaining 27 practices were randomly allocated to IT and RC. A risk score incorporating routine practice data was used to identify people aged 40–69 years at high-risk of undiagnosed diabetes. In the screening practices, high-risk individuals were invited to take part in a stepwise screening programme. In the IT group, diabetes treatment is optimised through guidelines, target-led multifactorial treatment, audit, feedback, and academic detailing for practice teams, alongside provision of educational materials for newly diagnosed participants. Primary endpoints are modelled cardiovascular risk at one year, and cardiovascular mortality and morbidity at five years after diagnosis of diabetes. Secondary endpoints include all-cause mortality, development of renal and visual impairment, peripheral neuropathy, health service costs, self-reported quality of life, functional status and health utility. Impact of the screening programme at the population level is also assessed through measures of mortality, cardiovascular morbidity, health status and health service use among high-risk individuals. Discussion ADDITION-Cambridge is conducted in a defined high-risk group

  15. Factors affecting reservoir and stream-water quality in the Cambridge, Massachusetts, drinking-water source area and implications for source-water protection

    Science.gov (United States)

    Waldron, Marcus C.; Bent, Gardner C.

    2001-01-01

    This report presents the results of a study conducted by the U.S. Geological Survey, in cooperation with the city of Cambridge, Massachusetts, Water Department, to assess reservoir and tributary-stream quality in the Cambridge drinking-water source area, and to use the information gained to help guide the design of a comprehensive water-quality monitoring program for the source area. Assessments of the quality and trophic state of the three primary storage reservoirs, Hobbs Brook Reservoir, Stony Brook Reservoir, and Fresh Pond, were conducted (September 1997-November 1998) to provide baseline information on the state of these resources and to determine the vulnerability of the reservoirs to increased loads of nutrients and other contaminants. The effects of land use, land cover, and other drainage-basin characteristics on sources, transport, and fate of fecal-indicator bacteria, highway deicing chemicals, nutrients, selected metals, and naturally occurring organic compounds in 11 subbasins that contribute water to the reservoirs also was investigated, and the data used to select sampling stations for incorporation into a water-quality monitoring network for the source area. All three reservoirs exhibited thermal and chemical stratification, despite artificial mixing by air hoses in Stony Brook Reservoir and Fresh Pond. The stratification produced anoxic or hypoxic conditions in the deepest parts of the reservoirs and these conditions resulted in the release of ammonia nitrogen orthophosphate phosphorus, and dissolved iron and manganese from the reservoir bed sediments. Concentrations of sodium and chloride in the reservoirs usually were higher than the amounts recommended by the U.S. Environmental Protection agency for drinking-water sources (20 milligrams per liter for sodium and 250 milligrams per liter for chloride). Maximum measured sodium concentrations were highest in Hobbs Brook Reservoir (113 milligrams per liter), intermediate in Stony Brook Reservoir (62

  16. Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays.

    Science.gov (United States)

    Keen, P; Conway, D P; Cunningham, P; McNulty, A; Couldwell, D L; Davies, S C; Smith, D E; Gray, J; Holt, M; O'Connor, C C; Read, P; Callander, D; Prestage, G; Guy, R

    2017-01-01

    The Trinity Biotech Uni-Gold HIV test (Uni-Gold) is often used as a supplementary rapid test in testing algorithms. To evaluate the operational performance of the Uni-Gold as a first-line screening test among gay and bisexual men (GBM) in a setting where 4th generation HIV laboratory assays are routinely used. We compared the performance of Uni-Gold with conventional HIV serology conducted in parallel among GBM attending 22 testing sites. Sensitivity was calculated separately for acute and established infection, defined using 4th generation screening Ag/Ab immunoassay (EIA) and Western blot results. Previous HIV testing history and results of supplementary 3rd generation HIV Ab EIA, and p24 antigen EIA were used to further characterise cases of acute infection. Of 10,793 specimens tested with Uni-Gold and conventional serology, 94 (0.90%, 95%CI:0.70-1.07) were confirmed as HIV-positive by conventional serology, and 37 (39.4%) were classified as acute infection. Uni-Gold sensitivity was 81.9% overall (77/94, 95%CI:72.6-89.1); 56.8% for acute infection (21/37, 95%CI:39.5-72.9) and 98.2% for established infection (56/57, 95%CI:90.6-100.0). Of 17 false non-reactive Uni-Gold results, 16 were acute infections, and of these seven were p24 antigen reactive but antibody negative. Uni-Gold specificity was 99.9% (10,692/10,699, 95%CI:99.9-100.0), PPV was 91.7% (95%CI:83.6-96.6) and NPV was 99.8% (95%CI:99.7-99.9), respectively. In this population, Uni-Gold had good specificity and sensitivity was high for established infections when compared to 4th generation laboratory assays, however sensitivity was lower in acute infections. Where rapid tests are used in populations with a high proportion of acute infections, additional testing strategies are needed to detect acute infections. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Gregory Nagy. Poetry as Performance, Homer and Beyond y Homeric Questions : Cambridge-New York-Melbourne, Cambridge University Press, 1996, ix + 254 pp. y Austin, University of Texas Press, 1996, ix + 180 pp., respectivamente

    OpenAIRE

    Zecchin de Fasano, Graciela Cristina

    1997-01-01

    Abordar la épìca homérica desde la perspectiva del canto-recitación involucrado en ella ha sido la premisa definitoria en la corriente crítica inaugurada por A. Lord, en la que debemos ubicar Poetry as performance de Nagy, resultado de su exposición en J. H. Gray Lectures, en la University of Cambridge durante 1993. El aporte particular de Nagy, carácter distintivo de su posición crítica, consiste en analizar la épica homérica desde la perspectiva de los conceptos performance y composition, e...

  18. Synthetic Biology in the Biotech Patent Landscape

    Directory of Open Access Journals (Sweden)

    Viviana García-llerena

    2016-12-01

    Full Text Available Recently, the intended positive effects of the current patent system in biotechnological research have been widely questioned. As part of this review, it is discussed here one of the foundations of the model. The assumption of the indispensability of patents is examined through the analysis of their expected benefits; namely, that patents are suitable to ensure access to information, access to and use of inventions and, finally, that they should promote both creativity and research. Applied to synthetic biology, in spite of newly discovered techniques and promising products, this approach reveals that this discipline also encounters similar issues. However, it also offers a new vision of intellectual property rights and their effects on research, which is based on a different conception of the commons and its relationship with private ownership of intangible assets in the knowledge economy.

  19. Synthetic Biology in the Biotech Patent Landscape

    OpenAIRE

    Viviana García-llerena

    2016-01-01

    Recently, the intended positive effects of the current patent system in biotechnological research have been widely questioned. As part of this review, it is discussed here one of the foundations of the model. The assumption of the indispensability of patents is examined through the analysis of their expected benefits; namely, that patents are suitable to ensure access to information, access to and use of inventions and, finally, that they should promote both creativity and research. Applied t...

  20. Comparative safety assessment for biotech crops

    NARCIS (Netherlands)

    Kok, E.J.; Kuiper, H.A.

    2003-01-01

    Since the first discussions on strategies to assess the food safety of genetically modified (GM) crop plants, assessment of GM plants and derived tissues has been based on comparisons with their traditionally bred counterparts. This was termed the Principle of Substantial Equivalence. However,

  1. agri-biotech applications' biosafety initiative

    African Journals Online (AJOL)

    was held in Costa Rica in 1992, followed by a other countries ISAAA assists in introducing workshop in Argentina in the same year, and requested transgenic crops (Raman, 1994). Indonesia was the host country for a regional One specific example is the ISAAA brokered workshop in 1993. Through case studies project for ...

  2. agri—biotech applications' biosafety initiative

    African Journals Online (AJOL)

    developing countries to build their regulatory oversight mechanisms in a flexible approach. Workshops. enabIe scienfists and regulators to share their expertences with experts from countries with biosafety. regulafions in place. ISAAA brokered projects provide the opportunity for scientists involved to implement regulaüons ...

  3. What's fueling the biotech engine--2008.

    Science.gov (United States)

    Aggarwal, Saurabh

    2009-11-01

    Despite the global economic slowdown, biologics managed single-digit growth in 2008, driven mainly by continued high growth in sales of antibodies and insulins. Novel biologics in development look promising, but crowding, pricing and reimbursement are emerging as longer-term concerns.

  4. Bioenergy, solar biotech research in France, Europe

    Science.gov (United States)

    Chevallier, M. F.; Nussbaum, R.

    1985-03-01

    Advantages of unicellular photosynthetic systems, efficiency of photosynthetic conversion, Dunaliella Alga and biosynthesis of glycerol, applications for hydrocarbons, continuous cultures, immobilized cultures, culture techniques, and solar biotechnology are discussed.

  5. Biotech Business Lessons for Defense Acquisition

    Science.gov (United States)

    2016-01-01

    by manufacturing process technology insertion, changes are occurring in the R&D domain as well. The notion of working with the Food and Drug...replaced the buggy; the mobile phone supplanted Ma Bell; and petroleum displaced whale oil. Revolution is more likely in such an environment than the...budgets will provide near zero or negative real purchasing power. 26. An interesting word choice as biologically transformation is what a cell does when

  6. Communicating Biotech Advances: Fiction versus Reality.

    Science.gov (United States)

    Małyska, Aleksandra; Bolla, Robert; Twardowski, Tomasz

    2017-11-22

    Bioscience novels use selected technologies of genetic engineering and synthetic biology to create entertaining stories. These novels are usually based on scientific knowledge, but they may arouse public concerns about technology and drive public reluctance to accept innovative technologies. The scientific community must adopt more efficient communication and transparency. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. IDC perspectives on biotech SMME development

    CSIR Research Space (South Africa)

    Fourie, Christo

    2017-10-01

    Full Text Available twins • Augmented Reality • Blockchain • Cloud technology • Virtual Reality • Artificial Intelligence • Robotics • Internet of Things • Big data analytics • Industrial Internet of Things • 3D printing • Quantum computing • Next... Manufacturing & Tourism Value Chains are earmarked for special attention including proactive project development, whilst High Impact Sectors are exclusively reactive Enablers  Industrial Infrastructure  New Industries Special High Impact Sectors...

  8. PHP-HT (VitaResc Biotech).

    Science.gov (United States)

    Baldwin, A; Wiley, E

    2001-04-01

    VitaResc (formerly Apex) is developing PHP-HT, pyridoxalated hemoglobin polyoxyethylene conjugate, for the potential treatment of nitric oxide-induced shock (characterized by hypotension), associated with various etiologies, initially in septic shock. A phase I safety study and an initial phase I/II patient trial for NO-induced shock have been completed, and VitaResc has enrolled patients in three of five planned cohorts in a continuation of these trials to include a protocol of continuous infusion and dose escalation [330680,349187,390918]. The results from the dose escalation trials are expected to provide the basis for a randomized, controlled phase II/III pivotal trial of PHP-HT [390918]. VitaResc has licensed PHP-HT exclusively from Ajinomoto for all indications, worldwide, except Japan [275263]. Ajinomoto originally developed the human derived and chemically modified hemoglobin preparation as a blood substitute, but no development has been reported by the company since 1997 [275277,303577]. The other potential indications of PHP-HT include shock associated with burns, pancreatitis, hemodialysis and cytokine therapies [275277]. VitaResc expects the annual market potential of PHP-HT to exceed 1 billion dollars [330680].

  9. Correlates of time spent walking and cycling to and from work: baseline results from the commuting and health in Cambridge study

    Directory of Open Access Journals (Sweden)

    Panter Jenna

    2011-11-01

    Full Text Available Abstract Purpose Environmental perceptions and psychological measures appear to be associated with walking and cycling behaviour; however, their influence is still unclear. We assessed these associations using baseline data from a quasi-experimental cohort study of the effects of major transport infrastructural developments in Cambridge, UK. Methods Postal surveys were sent to adults who travel to work in Cambridge (n = 1582. Questions asked about travel modes and time spent travelling to and from work in the last week, perceptions of the route, psychological measures regarding car use and socio-demographic characteristics. Participants were classified into one of two categories according to time spent walking for commuting ('no walking' or 'some walking' and one of three categories for cycling ('no cycling', '1-149 min/wk' and ' ≥ 150 min/wk'. Results Of the 1164 respondents (68% female, mean (SD age: 42.3 (11.4 years 30% reported any walking and 53% reported any cycling to or from work. In multiple regression models, short distance to work and not having access to a car showed strong positive associations with both walking and cycling. Furthermore, those who reported that it was pleasant to walk were more likely to walk to or from work (OR = 4.18, 95% CI 3.02 to 5.78 and those who reported that it was convenient to cycle on the route between home and work were more likely to do so (1-149 min/wk: OR = 4.60, 95% CI 2.88 to 7.34; ≥ 150 min/wk: OR = 3.14, 95% CI 2.11 to 4.66. Positive attitudes in favour of car use were positively associated with time spent walking to or from work but negatively associated with cycling to or from work. Strong perceived behavioural control for car use was negatively associated with walking. Conclusions In this relatively affluent sample of commuters, a range of individual and household characteristics, perceptions of the route environment and psychological measures relating to car use were associated with

  10. “In my end is my beginning”. Una discussione sul caso trascurato dei Cambridge Ritualists fra antropologia comparativa, filosofia e pensiero scientifico - “In my end is my beginning”. An argument on the Cambridge Ritualists’ neglected case, on the wave of comparative anthropology, philosophy and scientific thought

    Directory of Open Access Journals (Sweden)

    Danila Cinellu

    2015-12-01

    Full Text Available Somehow rounding off an intellectual season in which humanities strongly lament the loss of Darwinian incitements, while exploiting both Wilson’s biophilia hypothesis and Rappaport’s engaged anthropology as springboards, this article wants to cast light on how two anthropologically undervalued manifestos of the Cambridge School – Harrison’s Themis (1912 and Cornford’s From Religion to Philosophy (1912 – laid the foundation of post-modern science. It highlights, in other words, how within evolutionary anthropology, to which we owe the birth of the comparative study of religions, were surreptitiously raised significant issues against eco-systemic disfunctionalities due to the scientific pattern rooted in Atomism and modern Cartesianism itself. In order to counteract the conventional belief that evolutionary anthropology was entirely shaped by the kind of Positivism of Illuministic inspiration, the association between the “mystic” and the “savage” will be once more taken into consideration. In this regard, a quite unreleased focus on Lévi-Strauss’ paradigm “le totémism du dedans” is deemed also essential. As a consequence, the unfairly forgotten Cambridge Ritualists, Harrison and Cornford, will be especially rehearsed in the light of their adoption of the philosophical Bergsonian concept of durée as a means of probing into the monist vision enshrined in the mysteric religion of Ancient Greece. It is basically the special attention allotted to the mystic’s incorporation of a limitless cyclic time which helps us to detect the extent to which both Harrison and Cornford aimed at propounding an ethical anthropology eager to denounce the forward end because of the obdurate human projection outside the sphere of Life itself. What this essay thus propounds is not a rehearsal of the Cambridge School for the sake of it. While advocating cumulative knowledge around the very same foundation of the “scientific study of

  11. The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies.

    Science.gov (United States)

    Bandelt, Hans-Jürgen; Kloss-Brandstätter, Anita; Richards, Martin B; Yao, Yong-Gang; Logan, Ian

    2014-02-01

    Since the determination in 1981 of the sequence of the human mitochondrial DNA (mtDNA) genome, the Cambridge Reference Sequence (CRS), has been used as the reference sequence to annotate mtDNA in molecular anthropology, forensic science and medical genetics. The CRS was eventually upgraded to the revised version (rCRS) in 1999. This reference sequence is a convenient device for recording mtDNA variation, although it has often been misunderstood as a wild-type (WT) or consensus sequence by medical geneticists. Recently, there has been a proposal to replace the rCRS with the so-called Reconstructed Sapiens Reference Sequence (RSRS). Even if it had been estimated accurately, the RSRS would be a cumbersome substitute for the rCRS, as the new proposal fuses--and thus confuses--the two distinct concepts of ancestral lineage and reference point for human mtDNA. Instead, we prefer to maintain the rCRS and to report mtDNA profiles by employing the hitherto predominant circumfix style. Tree diagrams could display mutations by using either the profile notation (in conventional short forms where appropriate) or in a root-upwards way with two suffixes indicating ancestral and derived nucleotides. This would guard against misunderstandings about reporting mtDNA variation. It is therefore neither necessary nor sensible to change the present reference sequence, the rCRS, in any way. The proposed switch to RSRS would inevitably lead to notational chaos, mistakes and misinterpretations.

  12. Construct and concurrent validity of the Cambridge neuropsychological automated tests in Portuguese older adults without neuropsychiatric diagnoses and with Alzheimer's disease dementia.

    Science.gov (United States)

    Matos Gonçalves, Marta; Pinho, Maria Salomé; Simões, Mário R

    2018-03-01

    We aimed to analyze the construct and concurrent validity of the Rapid Visual Information Processing (RVP), Paired Associates Learning (PAL), Reaction Time (RTI), and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB®). Inclusion criteria were checked in a first session. The CANTAB and additional pencil-and-paper tests were administered within 1 week. The participants (aged 69-96 years) were 137 Portuguese adults without neuropsychiatric diagnoses and 37 adults with mild-to-moderate Alzheimer's disease dementia. Comparisons were made between the CANTAB tests and between these tests and the Rey Complex Figure Test (RCFT), Verbal Fluency (VF) test, and some Wechsler Memory Scale-III and Wechsler Adult Intelligence Scale-III subtests. Most intra-test correlations were stronger than the CANTAB inter-test correlations. The RVP correlated more with VF animals (.44), the PAL with RCFT immediate recall (-.52), the RTI with RVP mean latency (.42), and the SWM with Spatial Span backward (-.39).

  13. Face ethnicity and measurement reliability affect face recognition performance in developmental prosopagnosia: evidence from the Cambridge Face Memory Test-Australian.

    Science.gov (United States)

    McKone, Elinor; Hall, Ashleigh; Pidcock, Madeleine; Palermo, Romina; Wilkinson, Ross B; Rivolta, Davide; Yovel, Galit; Davis, Joshua M; O'Connor, Kirsty B

    2011-03-01

    The Cambridge Face Memory Test (CFMT, Duchaine & Nakayama, 2006) provides a validated format for testing novel face learning and has been a crucial instrument in the diagnosis of developmental prosopagnosia. Yet, some individuals who report everyday face recognition symptoms consistent with prosopagnosia, and are impaired on famous face tasks, perform normally on the CFMT. Possible reasons include measurement error, CFMT assessment of memory only at short delays, and a face set whose ethnicity is matched to only some Caucasian groups. We develop the "CFMT-Australian" (CFMT-Aus), which complements the CFMT-original by using ethnicity better matched to a different European subpopulation. Results confirm reliability (.88) and validity (convergent, divergent using cars, inversion effects). We show that face ethnicity within a race has subtle but clear effects on face processing even in normal participants (includes cross-over interaction for face ethnicity by perceiver country of origin in distinctiveness ratings). We show that CFMT-Aus clarifies diagnosis of prosopagnosia in 6 previously ambiguous cases. In 3 cases, this appears due to the better ethnic match to prosopagnosics. We also show that face memory at short (face repetition. © 2011 Psychology Press, an imprint of the Taylor & Francis Group, an Informa business

  14. Comparison of the Diagnostic Accuracy of Neuropsychological Tests in Differentiating Alzheimer's Disease from Mild Cognitive Impairment: Can the Montreal Cognitive Assessment Be Better than the Cambridge Cognitive Examination

    Directory of Open Access Journals (Sweden)

    José Eduardo Martinelli

    2014-05-01

    Full Text Available Objective: Considering the lack of studies on measures that increase the diagnostic distinction between Alzheimer's disease (AD and mild cognitive impairment (MCI and on the role of the Cambridge Cognitive Examination (CAMCOG in this, our study aims to compare the utility of the CAMCOG, Mini-Mental State Examination (MMSE and Montreal Cognitive Assessment (MoCA in helping to differentiate AD from MCI in elderly people with >4 years of schooling. Method: A total of 136 elderly subjects - 39 normal controls as well as 52 AD patients and 45 MCI patients treated at the Institute of Geriatrics and Gerontology, Porto Alegre, Brazil - were assessed using the MMSE, CAMCOG, clock drawing test (CDT, verbal fluency test (VF, Geriatric Depression Scale and Pfeffer Functional Activities Questionnaire. Results: The results obtained by means of a receiver operating characteristic curve showed that the MoCA is a better screening test for differentiating elderly subjects with AD from those with MCI than the CAMCOG and MMSE as well as other tests such as the CDT and VF. Conclusion: The MoCA, more than the CAMCOG and the other tests, was shown to be able to differentiate AD from MCI, although, as Roalf et al. [Alzheimers Dement 2013;9:529-537] pointed out, further studies might lead to measures that will improve this differentiation.

  15. An investigation into the impact of question structure on the performance of first year physics undergraduate students at the University of Cambridge

    Science.gov (United States)

    Gibson, Valerie; Jardine-Wright, Lisa; Bateman, Elizabeth

    2015-07-01

    We describe a study of the impact of exam question structure on the performance of first year Natural Sciences physics undergraduates from the University of Cambridge. The results show conclusively that a student’s performance improves when questions are scaffolded compared with university style questions. In a group of 77 female students we observe that the average exam mark increases by 13.4% for scaffolded questions, which corresponds to a 4.9 standard deviation effect. The equivalent observation for 236 male students is 9% (5.5 standard deviations). We also observe a correlation between exam performance and A2-level marks for UK students, and that students who receive their school education overseas, in a mixed gender environment, or at an independent school are more likely to receive a first class mark in the exam. These results suggest a mis-match between the problem-solving skills and assessment procedures between school and first year university and will provide key input into the future teaching and assessment of first year undergraduate physics students.

  16. Base rates for depersonalization according to the 2-item version of the Cambridge Depersonalization Scale (CDS-2) and its associations with depression/anxiety in the general population.

    Science.gov (United States)

    Michal, Matthias; Glaesmer, Heide; Zwerenz, Rüdiger; Knebel, Achim; Wiltink, Jörg; Brähler, Elmar; Beutel, Manfred E

    2011-01-01

    Recently, the two item version of the Cambridge Depersonalization Scale (CDS-2) has been validated in a clinical sample and has demonstrated that it is a useful tool for the detection of clinically significant depersonalization (DP). In order to provide a framework for the interpretation of the CDS-2 scores the aim of this study was to achieve normative data of a representative sample of the German population and to evaluate the associations with depression, anxiety and sociodemographic characteristics. A nationally representative face-to-face household survey was conducted during the mid of 2009 in Germany. The sample comprised N = 2512 participants. The survey questionnaire consisted of the CDS-2, the Hospital Anxiety and Depression Scale, and demographic characteristics. Case level of DP was found for 3.4% of the participants without significant sex and age differences. Although DP was strongly associated with depression and anxiety, principal component analysis clearly supported the distinctiveness of the psychopathological syndromes of depression, anxiety and DP. A criterion standard diagnostic interview for DP, anxiety and depression was not included. The results provide a framework for the interpretation of the CDS-2 scores and support the view that DP is a common and distinct psychopathological syndrome. Copyright © 2010 Elsevier B.V. All rights reserved.

  17. Sensitivity and specificity of a briefer version of the Cambridge Cognitive Examination (CAMCog-Short) in the detection of cognitive decline in the elderly: An exploratory study.

    Science.gov (United States)

    Radanovic, Marcia; Facco, Giuliana; Forlenza, Orestes V

    2018-02-06

    To create a reduced and briefer version of the widely used Cambridge Cognitive Examination (CAMCog) battery as a concise cognitive test to be used in primary and secondary levels of health care to detect cognitive decline. Our aim was to reduce the administration time of the original test while maintaining its diagnostic accuracy. On the basis of the analysis of 835 CAMCog tests performed by 429 subjects (107 controls, 192 mild cognitive impairment [MCI], and 130 dementia patients), we extracted items that most contributed to intergroup differentiation, according to 2 educational levels (≤8 and >8 y of formal schooling). The final 33-item "low education" and 24-item"high education" CAMCog-Short correspond to 48.5% and 35% of the original version and yielded similar rates of accuracy: area under ROC curves (AUC) > 0.9 in the differentiation between controls × dementia and MCI × dementia (sensitivities > 75%; specificities > 90%); AUC > 0.7 for the differentiation between controls and MCI (sensitivities > 65%; specificities > 75%). The CAMCog-Short emerges as a promising tool for a brief, yet sufficiently accurate, screening tool for use in clinical settings. Further prospective studies designed to validate its diagnostic accuracy are needed. Copyright © 2018 John Wiley & Sons, Ltd.

  18. Associations between active commuting and physical activity in working adults: Cross-sectional results from the Commuting and Health in Cambridge study

    Science.gov (United States)

    Yang, Lin; Panter, Jenna; Griffin, Simon J.; Ogilvie, David

    2012-01-01

    Objective To quantify the association between time spent in active commuting and in moderate to vigorous physical activity (MVPA) in a sample of working adults living in both urban and rural locations. Methods In 2009, participants in the Commuting and Health in Cambridge study were sent questionnaires enquiring about sociodemographic characteristics and weekly time spent in active commuting. They were also invited to wear an accelerometer for seven days. Accelerometer data were used to compute the time spent in MVPA. Multiple regression models were used to examine the association between time spent in active commuting and MVPA. Results 475 participants (70% female) provided valid data. On average, participants recorded 55 (SD: 23.02) minutes of MVPA per day. For women, reporting 150 or more minutes of active commuting per week was associated with an estimated 8.50 (95% CI: 1.75 to 51.26, p = 0.01) additional minutes of daily MVPA compared to those who reported no time in active commuting. No overall associations were found in men. Conclusions Promoting active commuting might be an important way of increasing levels of physical activity, particularly in women. Further research should assess whether increases in time spent in active commuting are associated with increases in physical activity. PMID:22964003

  19. Italian normative data and validation of two neuropsychological tests of face recognition: Benton Facial Recognition Test and Cambridge Face Memory Test.

    Science.gov (United States)

    Albonico, Andrea; Malaspina, Manuela; Daini, Roberta

    2017-09-01

    The Benton Facial Recognition Test (BFRT) and Cambridge Face Memory Test (CFMT) are two of the most common tests used to assess face discrimination and recognition abilities and to identify individuals with prosopagnosia. However, recent studies highlighted that participant-stimulus match ethnicity, as much as gender, has to be taken into account in interpreting results from these tests. Here, in order to obtain more appropriate normative data for an Italian sample, the CFMT and BFRT were administered to a large cohort of young adults. We found that scores from the BFRT are not affected by participants' gender and are only slightly affected by participant-stimulus ethnicity match, whereas both these factors seem to influence the scores of the CFMT. Moreover, the inclusion of a sample of individuals with suspected face recognition impairment allowed us to show that the use of more appropriate normative data can increase the BFRT efficacy in identifying individuals with face discrimination impairments; by contrast, the efficacy of the CFMT in classifying individuals with a face recognition deficit was confirmed. Finally, our data show that the lack of inversion effect (the difference between the total score of the upright and inverted versions of the CFMT) could be used as further index to assess congenital prosopagnosia. Overall, our results confirm the importance of having norms derived from controls with a similar experience of faces as the "potential" prosopagnosic individuals when assessing face recognition abilities.

  20. Test-retest reliability analysis of the Cambridge Neuropsychological Automated Tests for the assessment of dementia in older people living in retirement homes.

    Science.gov (United States)

    Gonçalves, Marta Matos; Pinho, Maria Salomé; Simões, Mário R

    2016-01-01

    The validity of the Cambridge Neuropsychological Automated Tests has been widely studied, but their reliability has not. This study aimed to estimate the test-retest reliability of these tests in a sample of 34 older adults, aged 69 to 90 years old, without neuropsychiatric diagnoses and living in retirement homes in the district of Lisbon, Portugal. The battery was administered twice, with a 4-week interval between sessions. The Paired Associates Learning (PAL), Spatial Working Memory (SWM), Rapid Visual Information Processing, and Reaction Time tests revealed measures with high-to-adequate test-retest correlations (.71-.89), although several PAL and SWM measures showed susceptibility to practice effects. Two estimated standardized regression-based methods were found to be more efficient at correcting for practice effects than a method of fixed correction. We also found weak test-retest correlations (.56-.68) for several measures. These results suggest that some, but not all, measures are suitable for cognitive assessment and monitoring in this population.

  1. The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample.

    Science.gov (United States)

    Taylor, Jason R; Williams, Nitin; Cusack, Rhodri; Auer, Tibor; Shafto, Meredith A; Dixon, Marie; Tyler, Lorraine K; Cam-Can; Henson, Richard N

    2017-01-01

    This paper describes the data repository for the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) initial study cohort. The Cam-CAN Stage 2 repository contains multi-modal (MRI, MEG, and cognitive-behavioural) data from a large (approximately N=700), cross-sectional adult lifespan (18-87years old) population-based sample. The study is designed to characterise age-related changes in cognition and brain structure and function, and to uncover the neurocognitive mechanisms that support healthy cognitive ageing. The database contains raw and preprocessed structural MRI, functional MRI (active tasks and resting state), and MEG data (active tasks and resting state), as well as derived scores from cognitive behavioural experiments spanning five broad domains (attention, emotion, action, language, and memory), and demographic and neuropsychological data. The dataset thus provides a depth of neurocognitive phenotyping that is currently unparalleled, enabling integrative analyses of age-related changes in brain structure, brain function, and cognition, and providing a testbed for novel analyses of multi-modal neuroimaging data. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  2. The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.

    Science.gov (United States)

    Paterson, Louise M; Flechais, Remy S A; Murphy, Anna; Reed, Laurence J; Abbott, Sanja; Boyapati, Venkataramana; Elliott, Rebecca; Erritzoe, David; Ersche, Karen D; Faluyi, Yetunde; Faravelli, Luca; Fernandez-Egea, Emilio; Kalk, Nicola J; Kuchibatla, Shankar S; McGonigle, John; Metastasio, Antonio; Mick, Inge; Nestor, Liam; Orban, Csaba; Passetti, Filippo; Rabiner, Eugenii A; Smith, Dana G; Suckling, John; Tait, Roger; Taylor, Eleanor M; Waldman, Adam D; Robbins, Trevor W; Deakin, J F William; Nutt, David J; Lingford-Hughes, Anne R

    2015-09-01

    Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need for further study of brain mechanisms underpinning relapse circuitry. The Imperial College Cambridge Manchester (ICCAM) platform study is an experimental medicine approach to this problem: using functional magnetic resonance imaging (fMRI) techniques and selective pharmacological tools, it aims to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent, and healthy individuals to inform future drug development. Addiction studies typically involve small samples because of recruitment difficulties and attrition. We established the platform in three centres to assess the feasibility of a multisite approach to address these issues. Pharmacological modulation of reward, impulsivity and emotional reactivity were investigated in a monetary incentive delay task, an inhibitory control task, and an evocative images task, using selective antagonists for µ-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, randomised, crossover design. In two years, 609 scans were performed, with 155 individuals scanned at baseline. Attrition was low and the majority of individuals were sufficiently motivated to complete all five sessions (n=87). We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs. © The Author(s) 2015.

  3. The Cambridge Mindreading Face-Voice Battery for Children (CAM-C): complex emotion recognition in children with and without autism spectrum conditions.

    Science.gov (United States)

    Golan, Ofer; Sinai-Gavrilov, Yana; Baron-Cohen, Simon

    2015-01-01

    Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six 'basic' emotions, usually using still pictures of faces. This study describes a new battery of tasks for testing recognition of nine complex emotions and mental states from video clips of faces and from voice recordings taken from the Mindreading DVD. This battery (the Cambridge Mindreading Face-Voice Battery for Children or CAM-C) was given to 30 high-functioning children with ASC, aged 8 to 11, and to 25 matched controls. The ASC group scored significantly lower than controls on complex ER from faces and voices. In particular, participants with ASC had difficulty with six out of nine complex emotions. Age was positively correlated with all task scores, and verbal IQ was correlated with scores in the voice task. CAM-C scores were negatively correlated with parent-reported level of autism spectrum symptoms. Children with ASC show deficits in recognition of complex emotions and mental states from both facial and vocal expressions. The CAM-C may be a useful test for endophenotypic studies of ASC and is one of the first to use dynamic stimuli as an assay to reveal the ER profile in ASC. It complements the adult version of the CAM Face-Voice Battery, thus providing opportunities for developmental assessment of social cognition in autism.

  4. The Cambridge Companion to Dewey. Cambridge Companions to Philosophy

    Science.gov (United States)

    Cochran, Molly

    2010-01-01

    John Dewey (1859-1952) was a major figure of the American cultural and intellectual landscape in the first half of the twentieth century. While not the originator of American pragmatism, he was instrumental to its articulation as a philosophy and the spread of its influence beyond philosophy to other disciplines. His prolific writings encompass…

  5. Antithrombin Cambridge II(A384S) mutation frequency and antithrombin activity levels in 120 of deep venous thrombosis and 150 of cerebral infarction patients in a single center in Southern China.

    Science.gov (United States)

    Zhang, Guang-sen; Tang, Yang-ming; Tang, Mei-qing; Qing, Zi-Ju; Shu, Chang; Tang, Xiang-qi; Deng, Ming-yang; Tan, Li-ming

    2010-09-01

    Antithrombin Cambridge II(A384S) mutation shows a relatively high frequency in western population. Some studies suggest that the mutation is an independent genetic risk factor both for deep vein thrombosis (DVT) and for arterial thrombosis, but whether the mutation has racial difference or has a general significance for thrombophilia remains unclear. In this study we performed an analysis of the prevalence of the mutation in Chinese southern population; Also, the antithrombin activity levels were evaluated in each investigated individual. The studies included 120 patients with DVT, 150 patients with cerebral infarction, and 110 controls. The mutation was detected using polymerase chain reaction/PvuII restrictive fragment length polymorphism procedures. Antithrombin activity assay was done using chromogenic substrate method. The results showed that no antithrombin Cambridge II mutation was detected in all three groups (DVT, cerebral infarction and controls), the incidence was 0/380. Plasma antithrombin activity was 91.37% +/- 16.15% in the DVT patients and 102.68% +/- 13.10% in the controls; the antithrombin activity was significantly reduced in the DVT group (P Cambridge II mutation has a racial difference, and may not be a valuable risk factor of thrombophilia in Asian population, and antithrombin deficiency remains a major genetic risk factor for DVT patients in China.

  6. Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task.

    Science.gov (United States)

    Fujihara, Kazuyuki; Narita, Kosuke; Suzuki, Yusuke; Takei, Yuichi; Suda, Masashi; Tagawa, Minami; Ujita, Koichi; Sakai, Yuki; Narumoto, Jin; Near, Jamie; Fukuda, Masato

    2015-04-01

    The anterior cingulate cortex (ACC), consisting of the perigenual ACC (pgACC) and mid-ACC (i.e., affective and cognitive areas, respectively), plays a significant role in the performance of gambling tasks, which are used to measure decision-making behavior under conditions of risk. Although recent neuroimaging studies have suggested that the γ-aminobutyric acid (GABA) concentration in the pgACC is associated with decision-making behavior, knowledge regarding the relationship of GABA concentrations in subdivisions of the ACC with gambling task performance is still limited. The aim of our magnetic resonance spectroscopy study is to investigate in 20 healthy males the relationship of concentrations of GABA and glutamate+glutamine (Glx) in the pgACC, mid-ACC, and occipital cortex (OC) with multiple indexes of decision-making behavior under conditions of risk, using the Cambridge Gambling Task (CGT). The GABA/creatine (Cr) ratio in the pgACC negatively correlated with delay aversion score, which corresponds to the impulsivity index. The Glx/Cr ratio in the pgACC negatively correlated with risk adjustment score, which is reported to reflect the ability to change the amount of the bet depending on the probability of winning or losing. The scores of CGT did not significantly correlate with the GABA/Cr or Glx/Cr ratio in the mid-ACC or OC. Results of this study suggest that in the pgACC, but not in the mid-ACC or OC, GABA and Glx concentrations play a distinct role in regulating impulsiveness and risk probability during decision-making behavior under conditions of risk, respectively. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. The relationship between back pain and mortality in older adults varies with disability and gender: results from the Cambridge City over-75s Cohort (CC75C) study.

    Science.gov (United States)

    Docking, R E; Fleming, J; Brayne, C; Zhao, J; Macfarlane, G J; Jones, G T

    2015-04-01

    This study aims to determine whether older adults reporting back pain (BP) are at increased risk of premature mortality, specifically, to examine the association with disabling/non-disabling pain separately. Participants aged ≥75 years were recruited to the Cambridge City over-75s Cohort (CC75C) study. Participants answered interviewer-administered questions on BP and were followed up until death. The relationship between BP and mortality was examined using Cox regression, adjusted for potential confounding factors. Separate models were computed for men and women. From 1174 individuals with BP data, the date of death was known for 1158 (99%). A significant association was found between disabling BP and mortality (hazard ratio: 1.4; 95% confidence interval: 1.1-1.8) and this remained, albeit of borderline significance, following adjustment for socio-demographic variables and potential disease markers (1.3; 0.99-1.7). Further, this association was found to vary with sex: women experienced a 40% increase in the risk of mortality associated with disabling BP (1.4; 1.1-1.9), whereas no such increase was observed for men (1.0; 0.5-1.9). Participants with non-disabling BP were not at increased risk of mortality. This study confirmed previous findings regarding the relationship between pain and excess mortality. Further, we have shown that, among older adults, this association is specific to disabling pain and to women. Clinicians should be aware not only of the short-term implications of disabling BP but also the longer-term effects. Future research should attempt to understand the mechanisms underpinning this relationship to avoid excess mortality and should aim to determine why the relationship differs in men and women. © 2014 European Pain Federation - EFIC®

  8. Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort

    Science.gov (United States)

    Savory, L A; Griffin, S J; Williams, K M; Prevost, A T; Kinmonth, A-L; Wareham, N J; Simmons, R K

    2014-01-01

    Aims To describe change in self-reported diet and plasma vitamin C, and to examine associations between change in diet and cardiovascular disease risk factors and modelled 10-year cardiovascular disease risk in the year following diagnosis of Type 2 diabetes. Methods Eight hundred and sixty-seven individuals with screen-detected diabetes underwent assessment of self-reported diet, plasma vitamin C, cardiovascular disease risk factors and modelled cardiovascular disease risk at baseline and 1 year (n = 736) in the ADDITION-Cambridge trial. Multivariable linear regression was used to quantify the association between change in diet and cardiovascular disease risk at 1 year, adjusting for change in physical activity and cardio-protective medication. Results Participants reported significant reductions in energy, fat and sodium intake, and increases in fruit, vegetable and fibre intake over 1 year. The reduction in energy was equivalent to an average-sized chocolate bar; the increase in fruit was equal to one plum per day. There was a small increase in plasma vitamin C levels. Increases in fruit intake and plasma vitamin C were associated with small reductions in anthropometric and metabolic risk factors. Increased vegetable intake was associated with an increase in BMI and waist circumference. Reductions in fat, energy and sodium intake were associated with reduction in HbA1c, waist circumference and total cholesterol/modelled cardiovascular disease risk, respectively. Conclusions Improvements in dietary behaviour in this screen-detected population were associated with small reductions in cardiovascular disease risk, independently of change in cardio-protective medication and physical activity. Dietary change may have a role to play in the reduction of cardiovascular disease risk following diagnosis of diabetes. PMID:24102972

  9. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep.

    Science.gov (United States)

    Mullen, Michael P; Hanrahan, James P; Howard, Dawn J; Powell, Richard

    2013-01-01

    This paper concerns the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecX(G) and FecX(B)) and the third (FecG(H)) in GDF9. All three mutations segregate in Belclare sheep while one, FecX(B), has not been found in the Cambridge. Both Belclare and Cambridge breeds are relatively recently developed composites that have common ancestry through the use of genetic material from the Finnish Landrace and Lleyn breeds. The development of both composites also involved major contributions from exceptionally prolific ewes screened from flocks in Ireland (Belclare) and Britain (Cambridge) during the 1960s. The objective of the current study was to establish the likely origin of the mutations (FecX(G), FecX(B) and FecG(H)) through analysis of DNA from Finnish Landrace and Lleyn sheep, and Galway and Texel breeds which contributed to the development of the Belclare breed. Ewes with exceptionally high prolificacy (hyper-prolific ewes) in current flocks on Irish farms were identified to simulate the screening of ewes from Irish flocks in the 1960s. DNA was obtained from: prolific ewes in extant flocks of Lleyn sheep (n = 44) on the Lleyn peninsula in Wales; hyper-prolific ewes (n = 41); prolific Galway (n = 41) ewes; Finnish Landrace (n = 124) and Texel (n = 19) ewes. The FecX(G) mutation was identified in Lleyn but not in Finnish Landrace, Galway or Texel sheep; FecX(B) was only found among the hyper-prolific ewes. The FecG(H) mutation was identified in the sample of Lleyn sheep. It was concluded from these findings that the Lleyn breed was the most likely source of the FecX(G) and FecG(H) mutations in Belclare and Cambridge sheep and that the FecX(B) mutation came from the High Fertility line that was developed using prolific ewes selected from commercial flocks in Ireland in the 1960's and subsequently used in the genesis of the Belclare.

  10. Water-quality conditions, and constituent loads and yields in the Cambridge drinking-water source area, Massachusetts, water years 2005–07

    Science.gov (United States)

    Smith, Kirk P.

    2013-01-01

    The source water area for the drinking-water supply of the city of Cambridge, Massachusetts, encompasses major transportation corridors, as well as large areas of light industrial, commercial, and residential land use. Because of ongoing development in the drinking-water source area, the Cambridge water supply has the potential to be affected by a wide variety of contaminants. The U.S. Geological Survey (USGS) has monitored surface-water quality in the Hobbs Brook and Stony Brook Basins, which compose the drinking-water source area, since 1997 (water year 1997) through continuous monitoring and discrete sample collection and, since 2004, through systematic collection of streamwater samples during base-flow and stormflow conditions at five primary sampling stations in the drinking-water source area. Four primary sampling stations are on small tributaries in the Hobbs Brook and Stony Brook Basins; the fifth primary sampling station is on the main stem of Stony Brook and drains about 93 percent of the Cambridge drinking-water source area. Water samples also were collected at six secondary sampling stations, including Fresh Pond Reservoir, the final storage reservoir for the raw water supply. Storm runoff and base-flow concentrations of calcium (Ca), chloride (Cl), sodium (Na), and sulfate (SO4) were estimated from continuous records of streamflow and specific conductance for six monitoring stations, which include the five primary sampling stations. These data were used to characterize current water-quality conditions, estimate loads and yields, and describe trends in Cl and Na in the tributaries and main-stem streams in the Hobbs Brook and Stony Brook Basins. These data also were used to describe how streamwater quality is affected by various watershed characteristics and provide information to guide future watershed management. Water samples were analyzed for physical properties and concentrations of Ca, Cl, Na, and SO4, total nitrogen (TN), total phosphorus (TP

  11. The Cambridge companion to Galileo

    CERN Document Server

    1998-01-01

    This collection of essays is unparalleled in the depth of its coverage of all facets of Galileo's work. A particular feature of the volume is the treatment of Galileo's relationship with the Church. It will be of particular interest to philosophers, historians of science, cultural historians and those in religious studies. New readers and nonspecialists will find this the most convenient, accessible guide to Galileo available. Advanced students and specialists will find a conspectus of recent developments in the interpretation of Galileo.

  12. Why raspberries flourish in Cambridge

    DEFF Research Database (Denmark)

    Gretzinger, Susanne; Royer, Susanne; Brown, Kerry

    The activities and role of entrepreneurial milieu in fostering novel products are examined in this research. Creative ideas that initiate disjuncture from prevailing paradigms and form from the aggregation of individuals and concentrated efforts coalescing around a common problem are the subject ...

  13. Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study

    Directory of Open Access Journals (Sweden)

    Matthews Fiona E

    2008-03-01

    Full Text Available Abstract Background The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is encouraged as the most reliable method for researching older people's falls, though in clinical practice guidelines advise taking a history of any recalled falls. This study set out to inform service planning by describing the epidemiology of falls in advanced old age using both retrospectively and prospectively collected falls data. Methods Design: Re-survey of over-90-year-olds in a longitudinal cohort study – cross-sectional interview and intensive 12-month follow-up. Participants and setting: 90 women and 20 men participating in a population-based cohort (aged 91–105 years, in care-homes and community-dwelling recruited from representative general practices in Cambridge, UK Measurements: Prospective falls data were collected using fall calendars and telephone follow-up for one year after cross-sectional survey including fall history. Results 58% were reported to have fallen at least once in the previous year and 60% in the 1-year follow-up. The proportion reported to have fallen more than once was lower using retrospective recall of the past year than prospective reports gathered the following year (34% versus 45%, as were fall rates (1.6 and 2.8 falls/person-year respectively. Repeated falls in the past year were more highly predictive of falls during the following year – IRR 4.7, 95% CI 2.6–8.7 – than just one – IRR 3.6, 95% CI 2.0–6.3, using negative binomial regression. Only 1/5 reportedly did not fall during either the year before or after interview. Conclusion Fall rates in this representative sample of over-90-year-olds are even higher than previous reports from octogenarians. Recalled falls last year, particularly repeated falls, strongly predicted falls during follow-up. Similar proportions

  14. Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial.

    Science.gov (United States)

    Jebb, Susan A; Lovegrove, Julie A; Griffin, Bruce A; Frost, Gary S; Moore, Carmel S; Chatfield, Mark D; Bluck, Les J; Williams, Christine M; Sanders, Thomas Ab

    2010-10-01

    Insulin sensitivity (Si) is improved by weight loss and exercise, but the effects of the replacement of saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) or carbohydrates of high glycemic index (HGI) or low glycemic index (LGI) are uncertain. We conducted a dietary intervention trial to study these effects in participants at risk of developing metabolic syndrome. We conducted a 5-center, parallel design, randomized controlled trial [RISCK (Reading, Imperial, Surrey, Cambridge, and Kings)]. The primary and secondary outcomes were changes in Si (measured by using an intravenous glucose tolerance test) and cardiovascular risk factors. Measurements were made after 4 wk of a high-SFA and HGI (HS/HGI) diet and after a 24-wk intervention with HS/HGI (reference), high-MUFA and HGI (HM/HGI), HM and LGI (HM/LGI), low-fat and HGI (LF/HGI), and LF and LGI (LF/LGI) diets. We analyzed data for 548 of 720 participants who were randomly assigned to treatment. The median Si was 2.7 × 10(-4) mL · μU(-1) · min(-1) (interquartile range: 2.0, 4.2 × 10(-4) mL · μU(-1) · min(-1)), and unadjusted mean percentage changes (95% CIs) after 24 wk treatment (P = 0.13) were as follows: for the HS/HGI group, -4% (-12.7%, 5.3%); for the HM/HGI group, 2.1% (-5.8%, 10.7%); for the HM/LGI group, -3.5% (-10.6%, 4.3%); for the LF/HGI group, -8.6% (-15.4%, -1.1%); and for the LF/LGI group, 9.9% (2.4%, 18.0%). Total cholesterol (TC), LDL cholesterol, and apolipoprotein B concentrations decreased with SFA reduction. Decreases in TC and LDL-cholesterol concentrations were greater with LGI. Fat reduction lowered HDL cholesterol and apolipoprotein A1 and B concentrations. This study did not support the hypothesis that isoenergetic replacement of SFAs with MUFAs or carbohydrates has a favorable effect on Si. Lowering GI enhanced reductions in TC and LDL-cholesterol concentrations in subjects, with tentative evidence of improvements in Si in the LF-treatment group. This trial was

  15. Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial1234

    Science.gov (United States)

    Jebb, Susan A; Lovegrove, Julie A; Griffin, Bruce A; Frost, Gary S; Moore, Carmel S; Chatfield, Mark D; Bluck, Les J; Williams, Christine M; Sanders, Thomas AB

    2010-01-01

    Background: Insulin sensitivity (Si) is improved by weight loss and exercise, but the effects of the replacement of saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) or carbohydrates of high glycemic index (HGI) or low glycemic index (LGI) are uncertain. Objective: We conducted a dietary intervention trial to study these effects in participants at risk of developing metabolic syndrome. Design: We conducted a 5-center, parallel design, randomized controlled trial [RISCK (Reading, Imperial, Surrey, Cambridge, and Kings)]. The primary and secondary outcomes were changes in Si (measured by using an intravenous glucose tolerance test) and cardiovascular risk factors. Measurements were made after 4 wk of a high-SFA and HGI (HS/HGI) diet and after a 24-wk intervention with HS/HGI (reference), high-MUFA and HGI (HM/HGI), HM and LGI (HM/LGI), low-fat and HGI (LF/HGI), and LF and LGI (LF/LGI) diets. Results: We analyzed data for 548 of 720 participants who were randomly assigned to treatment. The median Si was 2.7 × 10−4 mL · μU−1 · min−1 (interquartile range: 2.0, 4.2 × 10−4 mL · μU−1 · min−1), and unadjusted mean percentage changes (95% CIs) after 24 wk treatment (P = 0.13) were as follows: for the HS/HGI group, −4% (−12.7%, 5.3%); for the HM/HGI group, 2.1% (−5.8%, 10.7%); for the HM/LGI group, −3.5% (−10.6%, 4.3%); for the LF/HGI group, −8.6% (−15.4%, −1.1%); and for the LF/LGI group, 9.9% (2.4%, 18.0%). Total cholesterol (TC), LDL cholesterol, and apolipoprotein B concentrations decreased with SFA reduction. Decreases in TC and LDL-cholesterol concentrations were greater with LGI. Fat reduction lowered HDL cholesterol and apolipoprotein A1 and B concentrations. Conclusions: This study did not support the hypothesis that isoenergetic replacement of SFAs with MUFAs or carbohydrates has a favorable effect on Si. Lowering GI enhanced reductions in TC and LDL-cholesterol concentrations in subjects, with tentative

  16. The Filistatidae in the Caribbean region, with a description of the new genus Antilloides, revision of the genus Filistatoides F. O. P.-Cambridge and notes on Kukulcania Lehtinen (Arachnida, Araneae).

    Science.gov (United States)

    Brescovit, Antonio D; Ruiz, Alexander Sánchez; Garcia, Giraldo Alayón

    2016-07-07

    A synopsis of Caribbean filistatid diversity is recorded herein. A new genus, Antilloides, is proposed for five new species exclusively found in the Antilles: A. abeli n. sp., A. cubitas n. sp., and A. mesoliticus n. sp. from Cuba; A. haitises n. sp. from the Dominican Republic; and A. zozo n. sp. from the U. S. Virgin Islands and Puerto Rico. The genus Filistatoides is revised and includes four species: the type species F. insignis F.O.P. Cambridge, which occurs only in Guatemala; the female is described here for the first time; F. polita Franganillo sp. reval., comb. nov., which occurs only in Cuba; F. xichu n. sp. described from Mexico; and F. milloti (Zapfe) which does not appear to belong to the genus based on morphological structures. Additionally, Kukulcania isolinae Alayón is synonymized with Kukulcania hibernalis (Hentz), and new records of its distribution are included for the Greater and Lesser Antilles.

  17. 從WTO生技產品案爭端解決小組報告看GMO國際貿易中國際貿易法與國際環境法之衝突與解決可能 Conflicts and Resolutions of International Trade Law and International Law of Environment in International Trade of GMOs: A Perspective of WTO Biotech Products Case

    Directory of Open Access Journals (Sweden)

    許耀明 Yao-Ming Hsu

    2007-06-01

    Full Text Available 本文從國際貿易法與國際環境法一般理論角度出發,討論WTO 法規範體系與其他多邊環境協定之貿易措施間可能之衝突,並分析WTO 貿易與環境委員會以及爭端解決機制對於前述衝突之防止與多邊主義協商方式之提倡。其次,針對前述解決方式之不足,本文從法律解釋與法規範衝突法則之角度,論述前述可能衝突之調和方式。最後,本文以新近WTO 生技產品案報告為例,討論WTO 爭端解決機制中適用其他國際法規範之可能性以為說明。 From general theories of international trade law and international law of environment, this article focuses on the possible conflicts between WTO legal systems and Multilateral Environmental Agreements. It illustrates the possible resolutions from the point of view of Committee on Trade and Environment (CTE in WTO and its Dispute Settlement Body (DSB, and their promotion of multilateralism. Besides, this article analyses the possible resolutions from the legal interpretation and the rules of Conflicts of Norms, too. At last, it indicates an example of these possible conflicts and resolutions, the recent WTO Biotech Products Case, to demonstrate the possibility for the DSB to refer to others international norms in concrete cases.

  18. 24 January 2012 - British Vice-Chancellor of the University of Cambridge Sir Leszek Borysiewicz signing the guest book with CERN Director-General, visiting ATLAS experimental area with Collaboration Deputy Spokesperson D. Charlton and Sm18 with engineer R. Veness.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    24 January 2012 - British Vice-Chancellor of the University of Cambridge Sir Leszek Borysiewicz signing the guest book with CERN Director-General, visiting ATLAS experimental area with Collaboration Deputy Spokesperson D. Charlton and Sm18 with engineer R. Veness.

  19. 17 January 2011 - British (Cambridge) Trustee of the London Science Museum Chair of the Management Committee of the Newton Institute for Mathematical Sciences H. Covington in the LHCB underground experimental area with A. Schopper; signing the guest book with Director for Accelerators and Technology S. Myers; throughout accompanied by R. Veness.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    17 January 2011 - British (Cambridge) Trustee of the London Science Museum Chair of the Management Committee of the Newton Institute for Mathematical Sciences H. Covington in the LHCB underground experimental area with A. Schopper; signing the guest book with Director for Accelerators and Technology S. Myers; throughout accompanied by R. Veness.

  20. A combined theoretical and Cambridge Structural Database study of π-hole pnicogen bonding complexes between electron rich molecules and both nitro compounds and inorganic bromides (YO2Br, Y = N, P, and As).

    Science.gov (United States)

    Bauzá, Antonio; Ramis, Rafael; Frontera, Antonio

    2014-04-17

    Quantum calculations at the DFT-D3/def2-TZVPD level of theory have been used to examine complexes between O2YBr (Y═N, P, and As) molecules and several Lewis bases, that is, NH3, H2O, and HF. The interactions of the lone pair of the ammonia, water, and hydrogen fluoride with the σ-hole and π-hole of O2YBr molecules have been considered. In general, the complexes where the Lewis base lone pair interacts with the π-hole are more favorable than those with σ-hole. The nature of the interactions has been characterized with the Bader theory of atoms in molecules (AIM). We have also studied the ability of trifluoronitromethane and nitromethane to interact with anions using their π-hole along with an analysis the Cambridge Structural Database. We have found a large number of hits that provide strong experimental support for ability of the nitryl (-NO2) group to interact with anions and Lewis bases. In some X-ray structures, the π-hole interaction is crucial in the crystal packing and has a strong influence in the solid state architecture of the complexes. Finally, due to the relevance in atmospheric chemistry, we have studied noncovalent σ/π-hole complexes of nitryl bromide with ozone.

  1. Establishing a biotech-modern-agriculture for China

    African Journals Online (AJOL)

    AJL

    2011-11-16

    Nov 16, 2011 ... 1Center for Agricultural Resource Research, Institute of Genetics and Developmental Biology of Chinese Academy of. Sciences (CAS) ... 2Bureau of Biology and Biotechnology, Chinese Academy of Sciences (CAS), Beijing 100864, China. ..... irregularly publish “Biotec crop update” and “Biofuels.

  2. Nig J. Biotech. Vol. 21 (2010) 25 – 30

    African Journals Online (AJOL)

    BSN

    Laboratory for Plant Tissue Culture and Biotechnology, Department of Botany, University of ... rank second in importance only to cassava. ... The culture flasks containing the media were sealed with parafilm and sterilized by autoclaving at. 1210C and 1.05 kg cm-2 pressure for 20 min. The surface – sterilized explants were.

  3. Biotechnology regulation: limiting or contributing to biotech development?

    DEFF Research Database (Denmark)

    Hansen, Anne Grethe

    2001-01-01

    Modern biotechnology has been characterized by being surrounded by scientific and public debate and by interest conflicts. An early Danish debate and regulation has been criticized for inhibiting or retarding development and thus growth. Though much regulation and debate have been transferred to ...

  4. Careers at Biotech Start-Ups and in Entrepreneurship.

    Science.gov (United States)

    Froshauer, Susan

    2017-11-01

    The world of biotechnology "start-ups" and entrepreneurship offers exciting new avenues for driving state-of-the-art research using an arsenal of multidisciplinary skills, whether your role is as part of a team or as a leader. Although traditionally these positions may not be as secure as those offered by some of the larger companies, the small start-up culture provides opportunities for contributing at many levels to a wide range of responsibilities: from scientific discovery to delivery of proof of concept and intellectual property; from analysis of market opportunities and competitive intelligence to creation of time lines and business plans for a first product. Often, if you get in on the ground level, you get to validate your own concept, pitch to potential investors, argue value, build a team, engage advisors, and then, with funding in hand, launch an entirely new research and development (R&D) enterprise. Many of the skills and much of the experience gained while pursuing a graduate degree can be put to good use in these arenas as well. This path, however, is not for the faint of heart; it requires not only a strong scientific background and organizational skills, but also the ability to work well on a team, excellent communication skills, and persistence when faced with delays or disappointment. With increasing responsibilities in the small company come the requirements for aptitudes for leadership, strategic and financial planning, networking, negotiating, and managing both projects and personnel. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  5. Research in the Biotech Age: Can Informational Privacy Compete?

    Science.gov (United States)

    Peekhaus, Wilhelm

    2008-01-01

    This article examines the privacy of personal medical information in the health research context. Arguing that biomedical research in Canada has been caught up in the government's broader neoliberal policy agenda that has positioned biotechnology as a strategic driver of economic growth, the author discusses the tension between informational…

  6. Biotech prospects for the control of introduced mammals in Australia.

    Science.gov (United States)

    Seamark, R F

    2001-01-01

    More than twenty exotic vertebrate species are now listed as pests in Australia. Collectively, these pests have a huge economic and environmental impact and pose a major threat to Australia's ecosystems and unique biodiversity. Management of such pests on a continental scale is a major challenge. Recent advances in biotechnology suggest alternatives to the lethal diseases normally sought for use as biological control agents. One proposal, being investigated in the Pest Animal Control Cooperative Research Centre, Canberra, is the use of biotechnology to develop a new generation of agents that act through controlling reproduction to prevent the build up of pest populations. The core concept is fertility control through immunocontraceptive vaccines delivered by viruses that specifically infect the target pest population. Proof of this exciting concept has been obtained for the mouse and, very recently, the rabbit, and a candidate vaccine vector identified for the fox, portending better control of a trio of Australia's most pervasive pests. Other advances in biotechnology suggest ways to negate the build up of both innate and acquired immune resistance in target pest populations that normally act to limit the efficacy and effective life of biocontrol agents in the field. Prospects for extending the use of virally vectored vaccines to the field management of wildlife diseases are also identified. Targets for such vaccines include a growing suite of emerging diseases, hosted by Australia's wildlife, which pose a threat to human and livestock health. Numerous technical challenges remain to be addressed before any of these new agents are ready for use in the field. However, the major risk to their development is now no longer viewed as being technical, but the failure to gain public acceptance for their use in the field. This already significant risk is exasperated by the present heightened level of public concern about all introductions of genetically modified organisms.

  7. Evaluation and Audience Acceptance in Biotech News Texts

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte; Vestergaard, Torben

    2009-01-01

    the audience of a particular viewpoint. Moreover, it is shown that the newspaper caters to a readership which sees risk as a societal and ethical issue rather than a scientific one. Along these lines, the imagined reader is constructed as a less change oriented person than the reader of the newspaper's opinion...

  8. Establishing a biotech-modern-agriculture for China | Zhengbin ...

    African Journals Online (AJOL)

    China, with a large population and small amount of arable land, is a populous as well as a large agricultural country. In order to ensure food security, agricultural sustainable development and prosperity of agriculture economy, modern agriculture based on biotechnology combined with modern equipment must be ...

  9. Nig J. Biotech. Vol. 21 (2010) 35 – 40

    African Journals Online (AJOL)

    BSN

    Lactobacillus acidophilus. -. -. -. -. +. 1. Staphylococcus species. -. +. -. -. -. 1. Yeast. Kloeckera apiculata. -. -. +. +. -. 2. Saccharomyces cerevisiae. -. +. +. +. +. 4. Total. 5. 4. 6. 6. 3. 24. A* = H. sabdariffa, B = C. citrates, C = C.limon, D = Experimental tea mixture (H. sabdariffa). E = C.sinensis tea (control), + = present, - = absent.

  10. THE ROLE OF BIOTECH:'\\OLOGY IN CROP IMPROVEMENT ...

    African Journals Online (AJOL)

    BSN

    Biotechnology is currently playing a vital role in the impro\\ ement of crop plants generally. This is because of its ability to overcome the shortcomings of other conventional practices of crop improvement. This paper therefore. considered the l\\\\O broad aspects of Biotechnology in crop improvement name I); Genetic ...

  11. Reseña de Toner, J. (2012 Sesenta Millones de Romanos. La cultura del pueblo en la Antigua Roma. Barcelona: Crítica. Traducción de Luis Noriega, Título original, Popular Culture in Ancient Rome. Cambridge: Polity Press, 2009, pp. 363.

    Directory of Open Access Journals (Sweden)

    Juan Manuel Gerardi

    2014-11-01

    Full Text Available En este trabajo comento el contenido y el enfoque del libro de Jerry Toner, director de estudios clásicos en el Hughes Hall College de la Universidad de Cambridge, quien en Sesenta millones de romanos… estudia y caracteriza la cultura popular como un conjunto de estrategias empleadas por el pueblo romano para enfrentar los desafíos de la vida cotidiana.

  12. Nick Collins - Margaret Schedel - Scott Wilson, "Cambridge Introductions to Music. Electronic Music", Cambridge University Press, Cambridge, 2013

    Directory of Open Access Journals (Sweden)

    Giacomo Albert

    2015-05-01

    Full Text Available Scrivere nel 2013 un manuale introduttivo alla musica elettronica è un compito arduo: non soltanto per la dimensione storica di pratiche musicali le cui vicende si dipanano per ben più di un secolo ma, soprattutto, per l’enorme pluralità ed eterogeneità di esperienze che evoca la locuzione ‘musica elettronica’. Tantissime situazioni diverse tra loro, sviluppate in molteplici aree geografiche e non sempre in parallelo, anche se talora in connessione reciproca, afferenti a contesti produttivi, sfere sociali e luoghi di fruizione variegati, dunque difficili da riassumere in un volume unico, necessariamente orientato a rendere un senso di coerenza interna ed esprimere un punto di vista particolare. Nick Collins, Margaret Schedel e Scott Wilson affrontano una simile prova senza limitare l’universo della musica elettronica a un singolo, ristretto, ambito, nel tentativo di dipingerlo nella sua interezza, senza celarne la complessità intrinseca. La forma di un lavoro a più mani è sicuramente adatta all’obiettivo che i tre autori si sono proposti. Il fuoco intorno a cui ruota la struttura unitaria del volume è la tecnologia e la sua evoluzione nella storia, ripercorrendone la diffusione tra i compositori e allargando la prospettiva all’impatto che questa ha avuto nella società.

  13. Effects of socio-demographic variables on performance on the Cambridge neuropsychological automated tests for the assessment of dementia and Portuguese norms for older adults living in retirement homes.

    Science.gov (United States)

    Matos Gonçalves, Marta; Pinho, Maria Salomé; Rodrigues Simões, Mário

    2016-02-01

    This study aimed to analyze the effects of age, education, gender, computer experience, institutionalization time, and psychotropic drug use on performance on four tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) which are recommended for the assessment of dementia (Rapid Visual Information Processing [RVP], Paired Associates Learning [PAL], Spatial Working Memory [SWM], and Reaction Time [RTI]), and to provide norms for Portuguese older persons without neuropsychiatric diagnoses who are living in retirement homes. The normative sample included 128 adults aged 69-96 years who had no neuropsychiatric diagnosis and who had lived in retirement homes for 3-232 months. The CANTAB was administered, at the latest, one week after a screening session that comprised an interview and the administration of pencil-and-paper tests. The simultaneous multiple linear regression models were significant (p < .05) for all tests except the RTI five-choice movement time measure. The total variance explained by the socio-demographic variables was smaller for the CANTAB measures (4-14%) than for the pencil-and-paper tests (10-33%). Significant effects involving age or gender were observed for RVP, PAL, and SWM. A marginally significant computer experience effect was found for the RTI simple movement time measure. We additionally observed significant effects of education, age, gender, and computer experience on several pencil-and-paper tests. Our findings suggest that different socio-demographic variables influence distinct tests and measures of the same test, and that the associations between computer experience and several pencil-and-paper tests may be mediated by possible cognitive skills developed through computer use.

  14. Optical and molecular characterization of dissolved organic matter (DOM) in the Arctic ice core and the underlying seawater (Cambridge Bay, Canada): Implication for increased autochthonous DOM during ice melting.

    Science.gov (United States)

    Retelletti Brogi, Simona; Ha, Sun-Yong; Kim, Kwanwoo; Derrien, Morgane; Lee, Yun Kyung; Hur, Jin

    2018-02-01

    Sea ice contains a large amount of dissolved organic matter (DOM), which can be released into the ocean once it melts. In this study, Arctic sea ice DOM was characterized for its optical (fluorescence) properties as well as the molecular sizes and composition via size exclusion chromatography and Fourier transformation ion cyclotron resonance mass spectrometry (FT-ICR MS). Ice cores were collected along with the underlying seawater samples in Cambridge Bay, an Arctic area experiencing seasonal ice formation. The ice core samples revealed a marked enrichment of dissolved organic carbon (DOC) compared to the seawater counterparts (up to 6.2 times greater). The accumulation can be attributed to in situ production by the autotrophic and heterotrophic communities. Fluorescence excitation emission matrices (EEMs) elaborated with parallel factor analysis (PARAFAC) evidenced the prevalence of protein-like substances in the ice cores, which likely results from in situ production followed by accumulation in the ice. Size exclusion chromatography further revealed the in situ production of all DOM size fractions, with the exception of the humic substance fraction. The majority of DOM in both the ice and seawater consists of low molecular weight compounds (<350 Da) probably derived by the microbial degradation/transformation of freshly produced DOM. Molecular characterization also supported the in situ production of DOM and highlighted the marked difference in molecular composition between sea ice and seawater. This study provides new insights into the possible role of sea ice DOM in the Arctic carbon cycle under climate change. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. The Cambridge photographic atlas of galaxies

    CERN Document Server

    König, Michael

    2017-01-01

    Galaxies - the Milky Way's siblings - offer a surprising variety of forms and colours. Displaying symmetrical spiral arms, glowing red nebulae or diffuse halos, even the image of a galaxy can reveal much about its construction. All galaxies consist of gas, dust and stars, but the effects of gravity, dark matter and the interaction of star formation and stellar explosions all influence their appearances. This volume showcases more than 250 of the most beautiful galaxies within an amateur's reach and uses them to explain current astrophysical research. It features fantastic photographs, unique insights into our knowledge, tips on astrophotography and essential facts and figures based on the latest science. From the Andromeda Galaxy to galaxy clusters and gravitational lenses, the nature of galaxies is revealed through these stunning amateur photographs. This well illustrated reference atlas deserves a place on the bookshelves of astronomical imagers, observers and armchair enthusiasts.

  16. The Cambridge Handbook of Multimedia Learning

    Directory of Open Access Journals (Sweden)

    Malbrán, María del Carmen

    2007-01-01

    Full Text Available Durante la última década el campo del aprendizaje multimediado ha emergido como una disciplina coherente basada en la investigación. El Manual presenta un panorama actualizado y comprensivo de ambos. Este tipo de aprendizaje tiene lugar a través de palabras (textos orales e impresos e imágenes (ilustraciones, fotografías, mapas, animaciones, video. El Manual se centra en el modo en que se aprende con estos recursos en contextos mediados por la computadora.

  17. The Cambridge guide to the solar system

    National Research Council Canada - National Science Library

    Lang, Kenneth R

    2011-01-01

    ...; the encounter with asteroid Itokawa; and an encounter and sample return from comet Wild 2. The book is further enhanced by hundreds of striking new images of the planets and moons. Written at an introductory level appropriate for high-school and undergraduate students, it provides fresh insights that appeal to anyone with an interest in planetar...

  18. Air Force Cambridge Research Laboratories balloon operations

    Science.gov (United States)

    Danaher, T. J.

    1974-01-01

    The establishment and functions of the AFCRL balloon operations facility are discussed. The types of research work conducted by the facility are defined. The facilities which support the balloon programs are described. The free balloon and tethered balloon capabilities are analyzed.

  19. Copy-Editing: The Cambridge Handbook.

    Science.gov (United States)

    Butcher, Judith

    This handbook is designed as a reference manual for copy editors who prepare typescript for printing. It deals with the following topics: the copy editor's function; the work to be done at each stage in the production process; some difficult points of spelling, capitalization, and other features collectively known as "house style"; the parts of a…

  20. And Now What about Reforming Cambridge Governance?

    Science.gov (United States)

    Evans, G. R.

    2009-01-01

    After its recent Assurance visit from HEFCE, Oxford went through a high profile public debate at the end of which its academic community voted against moving to a governance structure which would have given Oxford a majority of external members on its Council. The Higher Education Funding Council asked Oxford to answer eight questions justifying…

  1. Analysis of N-H···O hydrogen bonds in new C(O)-NH-P(O)-based phosphoric triamides and analogous structures deposited in the Cambridge Structural Database.

    Science.gov (United States)

    Pourayoubi, Mehrdad; Toghraee, Maryam; Divjakovic, Vladimir; van der Lee, Arie; Mancilla Percino, Teresa; Leyva Ramírez, Marco A; Saneei, Anahid

    2013-04-01

    Five new compounds belonging to the phosphoric triamide family have been synthesized: two of them with the formula XC(O)NHP(O)Y [X = CF3 (1) and CClF2 (2), Y = NHCH2C(CH3)2CH2NH] involving a 1,3-diazaphosphorinane ring part, and three 2,6-Cl2C6H3C(O)NHP(O)Z2 phosphoric triamides [Z = NHC(CH3)3 (3), N(CH3)(C6H11) (4) and N(CH3)(CH2C6H5) (5)]. The characterization was performed by (31)P{(1)H}, (1)H, (13)C NMR, IR spectroscopy besides (19)F NMR for fluorine containing compounds (1) and (2), and X-ray single-crystal structure analysis for (1), (3), (4) and (5). In each molecule the P atom has a distorted tetrahedral environment. The N atoms bonded to P atom have mainly sp(2) character with a very slight tendency to a pyramidal coordination for some amido groups. Different types of N-H···O hydrogen bonds have been analyzed for (1), (3), (4) and (5) and 118 other structures (including 194 hydrogen bonds) deposited in the Cambridge Structural Database, containing either C(O)-NH-P(O)[N(C)(C)]2 or C(O)-NH-P(O)[NH(C)]2. The participation of N(CP)-H···O=P [N(CP) = the nitrogen atom of the C(O)-NH-P(O) fragment], N-H···O=P, N-H···O=C and N(CP)-H···O=C hydrogen bonds in different hydrogen-bonded motifs are discussed. Moreover, the involvement of the O atoms of C=O or P=O in the [N(CP)-H][N-H]···O=P, [N-H]2···O=P, [N-H]2···O=C and [N-H]3···O=C groups are considered. A histogram of N···O distances, the distribution of N-H···O angles and the scatterplot of N-H···O angles versus N···O distances are studied.

  2. Are changes in glycaemic control associated with diabetes-specific quality of life and health status in screen-detected type 2 diabetes patients? Four-year follow up of the ADDITION-Cambridge cohort.

    Science.gov (United States)

    Kuznetsov, L; Long, G H; Griffin, S J; Simmons, R K

    2015-01-01

    Interventions that improve HbA1c levels do not necessarily improve health-related quality of life (QoL). This issue may be particularly relevant in asymptomatic diabetes patients detected earlier in the course of the disease. HbA1c , diabetes-specific QoL (ADDQoL) and health status were measured in 510 screen-detected diabetes patients from the ADDITION-Cambridge trial at 1 and 5 years post diagnosis. Multivariable logistic/linear regression was used to quantify the longitudinal association between change in HbA1c from 1 to 5 years and ADDQoL and health status at 5 years, adjusting for age, sex, education and trial group; alcohol consumption, smoking, physical activity, plasma vitamin C, HbA1c , ADDQoL or health status at 1 year, and glucose-lowering medication at 5 years. From 1 to 5 years, median HbA1c interquartile range increased from 6.3% (5.9-6.8) to 6.8% (6.4-7.4); the median ADDQoL score and mean health status physical health summary score decreased from -0.4 (-1 to -0.08) to -0.5 (-1.08 to -0.09) (suggesting an adverse impact of diabetes on QoL) and by -0.79 (8.94) points, respectively. Increases in HbA1c were independently associated with reporting a negative impact of diabetes on QoL (OR = 1.38, 95% CI: 1.03 to 1.85) but not with the health status summary scores. Increases in HbA1c from 1 to 5 years post-diagnosis were independently associated with increased odds of reporting a negative impact of diabetes on QoL. While our results suggest that efforts to reduce HbA1c do not adversely affect health-related QoL, large numbers of participants still report a negative impact of diabetes on their QoL 5 years post-diagnosis. © 2014 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons, Ltd.

  3. (Review of) Reno, William. 2011. Warfare in Independent Africa. Cambridge: Cambridge University Press

    DEFF Research Database (Denmark)

    Hagmann, Tobias

    2013-01-01

    Warfare in Independent Africa is Reno’s bold attempt to analyze the modern history of African insurgencies. The book tackles this task through the prism of five generations of rebel, which left their mark on the continent; anti-colonial rebels, majority rule rebels, reform rebels, warlord rebels...

  4. Masters of Theory Cambridge and the Rise of Mathematical Physics

    CERN Document Server

    Warwick, Andrew

    2011-01-01

    Winner of the the Susan Elizabeth Abrams Prize in History of Science.When Isaac Newton published the Principia three centuries ago, only a few scholars were capable of understanding his conceptually demanding work. Yet this esoteric knowledge quickly became accessible in the nineteenth and early twentieth centuries when Britain produced many leading mathematical physicists. In this book, Andrew Warwick shows how the education of these "masters of theory" led them to transform our understanding of everything from the flight of a boomerang to the structure of the universe. Warwick focuses on Cam

  5. Learning about Intermolecular Interactions from the Cambridge Structural Database

    Science.gov (United States)

    Battle, Gary M.; Allen, Frank H.

    2012-01-01

    A clear understanding and appreciation of noncovalent interactions, especially hydrogen bonding, are vitally important to students of chemistry and the life sciences, including biochemistry, molecular biology, pharmacology, and medicine. The opportunities afforded by the IsoStar knowledge base of intermolecular interactions to enhance the…

  6. Cambridge journals blog: Improving feed efficiency in dairy production

    Science.gov (United States)

    Because the cost of feeding animals is one of the greatest expenses in dairy production (40-60% of production costs), research focused on ways to identify and select for animals that are the most efficient at converting feed into milk has greatly expanded during the last decade. The animal Article o...

  7. Book Review "Cambridge handbook of experimental political science"

    NARCIS (Netherlands)

    Grimmelikhuijsen, Stephan

    2014-01-01

    Experimentation has formed the basis for modern scientific discovery. Francis Bacon (1561– 1626), “the father of empiricism,” was one of the first to propose a method of science based on experimentation that results in new theories that can again be tested by experimentation. At first, experiments

  8. Residencia para enfermeras en Cambridge Gran Bretaña

    Directory of Open Access Journals (Sweden)

    Thurlow, David

    1977-12-01

    Full Text Available This residence, consisting of two floors and a l-shaped layout with wings of equal length, houses two independent apartments on the lower level and twelve dormitory type rooms equipped with bathrooms and kitchens common to every two rooms on the ground floor and to every four on the upper level. The project is characterized by its simplicity of design, which strives to harmonize the new structure, both in the materials and in the formal approach, with the traditional architecture present in the surroundings. In this direction, fundamentally, the solution adopted for the roof —covered with slate— stands out, which are interrupted for window openings and to provide abundant lighting for the central distributing corridor on the first floor which is distant from the perimeter. The achievements in the functional design are integrated into a pleasant and attractive solution which can be appreciated from both the inside and the outside.Esta Residencia, de dos niveles de altura y planta configurada como una «L» de brazos iguales, alberga dos apartamentos independientes en el nivel inferior, y doce salones-dormitorio, dotados de servicios de baño y cocina comunes a cada dos dormitorios, en planta baja, y a cada cuatro, en el nivel superior. El proyecto se caracteriza por su sencillez de diseño, que procura armonizar la nueva construcción, tanto en los materiales como en el planteamiento formal, con la arquitectura tradicional existente en el entorno. En este sentido se destaca, fundamentalmente, la solución adoptada para la cubierta, revestida de pizarra, que se interrumpe para abrir huecos de ventana y para iluminar abundantemente el corredor central de distribución en la planta primera, alejado del perímetro. Los logros en la solución funcional se integran en un diseño agradable y atractivo, apreciable tanto interior como exteriormente.

  9. University Chemical Laboratories, Lensfield Road. Cambridge CB2 ...

    African Journals Online (AJOL)

    The. combined organic layer was dried with. Na2SO.,, the solvent removed to give an oily residue. The residue was cleaned by column cinematography (ether) to give 2.78 g (91 %) which was further purified by recrystallisation to give 1.86 g (70%) of pure crystalline Meldruin's acid. Found 145.0491 (M* +1); MS m/z: I45.

  10. The Ecology of Language Evolution. Cambridge Approaches to Language Contact.

    Science.gov (United States)

    Mufwene, Salikoko S.

    This book explores the development of creoles and other new languages, highlighting conceptual and methodological issues for genetic linguistics and discussing the significance of ecologies that influence language evolution. It presents examples of changes in the structure, function, and vitality of languages, suggesting that similar ecologies…

  11. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    OpenAIRE

    Julian Herbert Köck

    2010-01-01

    Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftle...

  12. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008. Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    Directory of Open Access Journals (Sweden)

    Julian Herbert Köck

    2010-03-01

    Full Text Available Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftler/-innen auf, bietet aber – besonders zu Herodot und Strabon – auch neue Erkenntnisse.Stephanie Lynn Budin’s study offers up an important contribution to the debate on the existence of temple prostitution during antiquity. She systematically examines the sources on temple prostitution and can demonstrate, fairly convincingly, that the passages in question do not prove the existence of temple prostitution during antiquity, but instead have been merely understood to do so based on tendentious interpretations. In so doing, the study takes up conclusions offered by other scholars, but it also provides – especially when it comes to Herodotus and Strabo – new insights.

  13. Two cases of induced insanity. Helene Deutsch, Cambridge, Mass.

    Science.gov (United States)

    Roazen, P

    1981-01-01

    "Two cases of induced insanity", hitherto untranslated, was Helene Deutsch's first (1918) psychoanalytic paper; she presented Freud with a copy of it during the beginning of her analysis with him. As an experienced clinician who had studied under both Wagner von Jauregg in Vienna and Emil Kraepelin in Munich, Deutsch observed these cases during World War I as the University of Vienna's psychiatric facilities. Although the general reading public knows her best for her The Psychology of Women, she also wrote some well-known clinical papers; and it is characteristic of her that she brought these two cases without excessive theoretical speculation. In "Two cases in induced insanity" Deutsch described some of the strains of the wartime situation, and how whole families could join in hysterical confabulations in order to cope with emotional distress. One of her most famous later clinical contribution had to do with the emotional impoverishment of 'as if' personalities and their specific suggestibility. In other papers she continued her early concern with disturbed identification. As one examines Deutsch's work it is possible to fill out the history of psychoanalytic psychology. Without ignoring her later increase in theoretical sophistication, in "Two cases of induced insanity" we find Deutsch remarkably tolerant in her willingness to suspend judgement about the sources and fate of morbid thinking. A key therapeutic recommendation of hers was to separate the family members to allow their reality to return. Like some recent critics of undue diagnostic name-calling she advocated hesitation in discerning of disease entities as well as cautionary approach to treatment. The nature of familial love may leave everyone "normal" prone to disturbances which are not necessarily to be treated as a psychiatric illness. This example of one of Deutsch's first professional essays reflects the early thinking of a giant in psychoanalysis. She followed Freud in the conviction that the exceptional can highlight the everyday. The paper is a tentative groping and illustrates how far she came when she published her mature work.

  14. Rezension zu: Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    OpenAIRE

    Julian Herbert Köck

    2010-01-01

    Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftler/-innen auf, b...

  15. Rezension zu: Stephanie Lynn Budin: The Myth of Sacred Prostitution in Antiquity. Cambridge u.a.: Cambridge University Press 2008.

    Directory of Open Access Journals (Sweden)

    Julian Herbert Köck

    2010-01-01

    Full Text Available Stephanie Lynn Budin liefert mit vorliegender Studie einen wichtigen Beitrag zur Debatte um die Existenz von Tempelprostitution im Altertum. Systematisch untersucht sie die Quellen zur Tempelprostitution und kann weitgehend überzeugend darlegen, dass die betreffenden Stellen nicht für die Existenz von Tempelprostitution im Altertum sprechen, sondern nur aufgrund von tendenziösen Interpretationen so verstanden wurden. Dabei greift die Studie die Ergebnisse anderer Wissenschaftler/-innen auf, bietet aber – besonders zu Herodot und Strabon – auch neue Erkenntnisse.

  16. Validation of cross-contamination control in biological safety cabinet for biotech/pharmaceutical manufacturing process.

    Science.gov (United States)

    Hu, Shih-Cheng; Shiue, Angus; Tu, Jin-Xin; Liu, Han-Yang; Chiu, Rong-Ben

    2015-12-01

    For class II, type A2 biological safety cabinets (BSC), NSF/ANSI Standard 49 should be conformed in cabinet airflow velocity derivation, particle contamination, and aerodynamic flow properties. However, there exists a potential problem. It has been built that the cabinet air flow stabilize is influenced by the quantity of downflow of air and the height above the cabinet exhaust opening. Three air downflow quantities were compared as an operating apparatus was placed from 20 to 40 cm above the bench of the cabinet. The results show that the BSC air downflow velocity is a function of increased sampling height, displaying that containment is improvingly permitted over product protection as the sampling height decreases. This study investigated the concentration gradient of particles at various heights and downflow air quantity from the bench of the BSC. Experiment results indicate that performance near the bench was better than in the rest of the BSC. In terms of height, the best cleanliness was measured at a height of 10 cm over the bench; it reduced actually with add in height. The empirical curves accommodate, founded on the concentration gradient of particle created was elaborated for evaluating the particle concentration at different heights and downflow air quantity from the source of the bench of the BSC. The particle image velocimetry system applied for BSC airflow research to fix amount of airflow patterns and air distribution measurement and results of measurements show how obstructions can greatly influence the airflow and contaminant transportation in a BSC.

  17. Technical effect and scope of patent protection of chemical and biotech innovations

    Directory of Open Access Journals (Sweden)

    Vlašković Božin

    2013-01-01

    Full Text Available Whereas that sequences and parts of gene sequences by their nature are chemical substances, and not only holders of specific information, with the Directive no. 98/44 are actualizing, in a new light and in full measure, and are opening the issues about scope of patent protection for inventions chemical matters in general. Directive not given a direct answer to the question of the scope of their patent protection. However, the European Court of Justice decided that in the case of inventions sequences and parts of gene sequences that their protection limited with function which exercised.

  18. Blueprints for green biotech: development and application of standards for plant synthetic biology.

    Science.gov (United States)

    Patron, Nicola J

    2016-06-15

    Synthetic biology aims to apply engineering principles to the design and modification of biological systems and to the construction of biological parts and devices. The ability to programme cells by providing new instructions written in DNA is a foundational technology of the field. Large-scale de novo DNA synthesis has accelerated synthetic biology by offering custom-made molecules at ever decreasing costs. However, for large fragments and for experiments in which libraries of DNA sequences are assembled in different combinations, assembly in the laboratory is still desirable. Biological assembly standards allow DNA parts, even those from multiple laboratories and experiments, to be assembled together using the same reagents and protocols. The adoption of such standards for plant synthetic biology has been cohesive for the plant science community, facilitating the application of genome editing technologies to plant systems and streamlining progress in large-scale, multi-laboratory bioengineering projects. © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

  19. The global competition for talent: Life science and biotech careers, international mobility, and competitiveness

    NARCIS (Netherlands)

    Kuvik, A.N.

    2015-01-01

    This study argues that skilled human mobility and specifically that for occupations linked to innovation, such as for science and technology, has undergone a rapid and continuing internationalization. This change has theoretical implications and requires a greater merging of theories in diverse

  20. Perception of biotech trees by Slovak university students – a comparative survey

    Directory of Open Access Journals (Sweden)

    Moravčíková Jana

    2017-06-01

    Full Text Available Acceptance of genetically modified plants is restricted in EU by legislation, while the attitude of public is not favourable as well. Surveys show that knowledge about GM plants is getting increased. Newly developed strategies on GM safety for environment can be a crucial aspect for the (partial acceptance in future. GM trees as non-edible plants might appear as more admissible, however, are relatively rarely discussed. We performed a comparative survey on knowledge and perception of GM forest trees among students at four Slovak universities. We also compared their responses between as well as with the outcome of similar cross-country survey in frames of the COST Action FP0905. The results point to very similar attitude of Slovak students when compared with students from other countries, no significant difference between responses of males and females, but also influence of age as well as orientation of their study (natural sciences vs. economy on view of GM tree safety and placing on the market.

  1. 76 FR 42682 - China Biotech Life Sciences Trade Mission-Clarification and Amendment

    Science.gov (United States)

    2011-07-19

    ... that the mission is open to applications from U.S. architecture and design firms that specialize in the.... Architecture and Design Firms Specializing in This Sector As stated under Mission Description in the March 30... accepted through August 15th (and after that date if space remains and scheduling constraints permit...

  2. From petrochemistry to biotech: a European perspective on the bio-based economy

    OpenAIRE

    Landeweerd, Laurens; Surette, Monique; van Driel, Corry

    2011-01-01

    This paper gives an account of the issues at play in Europe with regard to the transition to a bio-based economy. Agricultural crops have always been used for the production of food, feed, fibre and fuel. The Model T Ford—the first mass produced car—originally ran on bioethanol, and wood has been in use as a source for energy ever since the discovery of fire. What is new is that the balance between agricultural uses is changing under the pressure of an increasing need for food and feed, as we...

  3. Additive Biotech-Chances, challenges, and recent applications of additive manufacturing technologies in biotechnology.

    Science.gov (United States)

    Krujatz, Felix; Lode, Anja; Seidel, Julia; Bley, Thomas; Gelinsky, Michael; Steingroewer, Juliane

    2017-10-25

    The diversity and complexity of biotechnological applications are constantly increasing, with ever expanding ranges of production hosts, cultivation conditions and measurement tasks. Consequently, many analytical and cultivation systems for biotechnology and bioprocess engineering, such as microfluidic devices or bioreactors, are tailor-made to precisely satisfy the requirements of specific measurements or cultivation tasks. Additive manufacturing (AM) technologies offer the possibility of fabricating tailor-made 3D laboratory equipment directly from CAD designs with previously inaccessible levels of freedom in terms of structural complexity. This review discusses the historical background of these technologies, their most promising current implementations and the associated workflows, fabrication processes and material specifications, together with some of the major challenges associated with using AM in biotechnology/bioprocess engineering. To illustrate the great potential of AM, selected examples in microfluidic devices, 3D-bioprinting/biofabrication and bioprocess engineering are highlighted. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. A Quantitative PCR-Electrochemical Genosensor Test for the Screening of Biotech Crops

    Directory of Open Access Journals (Sweden)

    Suely Moura-Melo

    2017-04-01

    Full Text Available The design of screening methods for the detection of genetically modified organisms (GMOs in food would improve the efficiency in their control. We report here a PCR amplification method combined with a sequence-specific electrochemical genosensor for the quantification of a DNA sequence characteristic of the 35S promoter derived from the cauliflower mosaic virus (CaMV. Specifically, we employ a genosensor constructed by chemisorption of a thiolated capture probe and p-aminothiophenol gold surfaces to entrap on the sensing layer the unpurified PCR amplicons, together with a signaling probe labeled with fluorescein. The proposed test allows for the determination of a transgene copy number in both hemizygous (maize MON810 trait and homozygous (soybean GTS40-3-2 transformed plants, and exhibits a limit of quantification of at least 0.25% for both kinds of GMO lines.

  5. Market entry and exit by biotech and device companies funded by venture capital.

    Science.gov (United States)

    Burns, Lawton R; Housman, Michael G; Robinson, Charles A

    2009-01-01

    Start-up companies in the biotechnology and medical device sectors are important sources of health care innovation. This paper describes the role of venture capital in supporting these companies and charts the growth in venture capital financial support. The paper then uses longitudinal data to describe market entry and exit by these companies. Similar factors are associated with entry and exit in the two sectors. Entries and exits in one sector also appear to influence entry in the other. These findings have important implications for developing innovative technologies and ensuring competitive markets in the life sciences.

  6. The role of contracts and trust in R&D alliances in the Dutch biotech sector

    NARCIS (Netherlands)

    Aalbers, H.L.

    2010-01-01

    This study explores the value of trust as a construct in understanding how R&D alliances collaborate over time. A review of literature leads to specific expectations on alliance coordination mechanisms needed to be applied by high-tech companies to secure effective cooperation. I pose trust as a

  7. A Quantitative PCR-Electrochemical Genosensor Test for the Screening of Biotech Crops

    Science.gov (United States)

    Moura-Melo, Suely; Miranda-Castro, Rebeca; de-los-Santos-Álvarez, Noemí; Miranda-Ordieres, Arturo J.; dos Santos Junior, José Ribeiro; da Silva Fonseca, Rosana A.; Lobo-Castañón, María Jesús

    2017-01-01

    The design of screening methods for the detection of genetically modified organisms (GMOs) in food would improve the efficiency in their control. We report here a PCR amplification method combined with a sequence-specific electrochemical genosensor for the quantification of a DNA sequence characteristic of the 35S promoter derived from the cauliflower mosaic virus (CaMV). Specifically, we employ a genosensor constructed by chemisorption of a thiolated capture probe and p-aminothiophenol gold surfaces to entrap on the sensing layer the unpurified PCR amplicons, together with a signaling probe labeled with fluorescein. The proposed test allows for the determination of a transgene copy number in both hemizygous (maize MON810 trait) and homozygous (soybean GTS40-3-2) transformed plants, and exhibits a limit of quantification of at least 0.25% for both kinds of GMO lines. PMID:28420193

  8. Who benefits from gm crops? Feeding the biotech giants, not the world's poor

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Villar, J.; Freese, B.; Holder, H.; Chandrasekaran, K.; Rodriguez, L.

    2009-02-15

    The biotechnology industry has aggressively touted GM as a solution to hunger and the global food crisis. Their arguments have been accepted by many politicians. This Friends of the Earth International (FoEI) report looks behind the spin and exposes the reasons why GM crops cannot, and are unlikely to ever, contribute to poverty reduction, global food security or sustainable farming (authors' abstract)

  9. Book review. Neurolinguistics. An Introduction to Spoken Language Processing and its Disorders, John Ingram. Cambridge University Press, Cambridge (Cambridge Textbooks in Linguistics) . xxi + 420 pp., ISBN 978-0-521-79640-8 (pb)

    NARCIS (Netherlands)

    Schiller, N.O.

    2009-01-01

    The present textbook is one of the few recent textbooks in the area of neurolinguistics and will be welcomed by teachers of neurolinguistic courses as well as researchers interested in the topic. Neurolinguistics is a huge area, and the boundaries between psycho- and neurolinguistics are not sharp.

  10. Book review. Neurolinguistics. An Introduction to Spoken Language Processing and its Disorders, John Ingram. Cambridge University Press, Cambridge (Cambridge Textbooks in Linguistics) (2007). xxi + 420 pp., ISBN 978-0-521-79640-8 (pb)

    OpenAIRE

    Schiller, N.O.

    2009-01-01

    The present textbook is one of the few recent textbooks in the area of neurolinguistics and will be welcomed by teachers of neurolinguistic courses as well as researchers interested in the topic. Neurolinguistics is a huge area, and the boundaries between psycho- and neurolinguistics are not sharp. Often the term neurolinguistics is used to refer to research involving neuropsychological patients suffering from some sort of language disorder or impairment. Also, the term neuro- rather than psy...

  11. Competiveness and Innovation in High-tech Companies: an Application to the Italian Biotech and Aerospace Industries

    OpenAIRE

    Armando Calabrese; Domenico Campisi; Guendalina Capece; Roberta Costa; Francesca Di Pillo

    2013-01-01

    Innovation activities are a critical factor in national and regional development. The innovative behaviour of companies is one of the main sources of competitiveness, business survival, economic growth and employment in a territory. It is therefore important to identify and understand the factors that determine innovation behaviour among enterprises. In line with this, the aim of this study is to analyse the relations between innovation‐related variables and the impact that they have on compa...

  12. Analytical criteria for performance characteristics of IgE binding methods for evaluating safety of biotech food products

    NARCIS (Netherlands)

    Holzhauser, Thomas; van Ree, Ronald; Poulsen, Lars K.; Bannon, Gary A.

    2008-01-01

    There is detailed guidance on how to perform bioinformatic analyses and enzymatic degradation studies for genetically modified crops under consideration for approval by regulatory agencies; however, there is no consensus in the scientific community on the details of how to perform IgE serum studies.

  13. Incubating Innovation: A standard model for nurturing new businesses, the incubator gains prominence in the world of biotech.

    Science.gov (United States)

    Grifantini, Kristina

    2015-01-01

    Incubators, accelerators, innovation centers, launch pads. Everyone defines the idea a bit differently, but, generally, these infrastructures refer to a subsidized space where fledgling companies get support?a combination of mentorship, funding, low rent, networking opportunities, and other training?with the goal of propelling early businesses to success.

  14. Electrochemical sensor for multiplex screening of genetically modified DNA: identification of biotech crops by logic-based biomolecular analysis.

    Science.gov (United States)

    Liao, Wei-Ching; Chuang, Min-Chieh; Ho, Ja-An Annie

    2013-12-15

    Genetically modified (GM) technique, one of the modern biomolecular engineering technologies, has been deemed as profitable strategy to fight against global starvation. Yet rapid and reliable analytical method is deficient to evaluate the quality and potential risk of such resulting GM products. We herein present a biomolecular analytical system constructed with distinct biochemical activities to expedite the computational detection of genetically modified organisms (GMOs). The computational mechanism provides an alternative to the complex procedures commonly involved in the screening of GMOs. Given that the bioanalytical system is capable of processing promoter, coding and species genes, affirmative interpretations succeed to identify specified GM event in terms of both electrochemical and optical fashions. The biomolecular computational assay exhibits detection capability of genetically modified DNA below sub-nanomolar level and is found interference-free by abundant coexistence of non-GM DNA. This bioanalytical system, furthermore, sophisticates in array fashion operating multiplex screening against variable GM events. Such a biomolecular computational assay and biosensor holds great promise for rapid, cost-effective, and high-fidelity screening of GMO. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Cross-cutting ties, organizational density, and new firm formation in the US biotech industry, 1994-1998

    NARCIS (Netherlands)

    Bae, J.; Wezel, F.C.; Koo, J.

    2011-01-01

    This study examines the role of cooperative relations among incumbents in the formation of new firms. We argue that cooperative interfirm relations that bridge geographically remote and diverse sources of knowledge—cross-cutting ties—contribute to new firm formation. Employing data on state-level

  16. The value of trust in biotech crop development: a case study of Bt cotton in Burkina Faso

    Directory of Open Access Journals (Sweden)

    Ezezika Obidimma C

    2012-11-01

    Full Text Available Abstract Background Agricultural biotechnology public-private partnerships (PPPs have been recognized as having great potential in improving agricultural productivity and increasing food production in sub-Saharan Africa. However, there is much public skepticism about the use of GM (genetically modified crops and suspicion about private sector involvement in agbiotech projects. This case study sought to understand the role of trust in the Bacillus thuringiensis (Bt cotton in Burkina Faso project by exploring practices and challenges associated with trust-building, and determining what makes these practices effective from the perspective of multiple stakeholders. Methods We conducted semi-structured, face-to-face interviews to obtain stakeholders’ understanding of trust in general as well as in the context of agbiotech PPPs. Relevant documents and articles were analyzed to generate descriptions of how trust was operationalized in this evolving agbiotech PPP. Data was analyzed based on emergent themes to create a comprehensive narrative on how trust is understood and built among the partners and with the community. Results We derived four key lessons from our findings. First, strong collaboration between research, industry and farmers greatly contributes to both the success of, and fostering of trust in, the partnership. Second, this case study also revealed the important, though often unrecognized, role of researchers as players in the communication strategy of the project. Third, effective and comprehensive communication takes into account issues such as illiteracy and diversity. Fourth, follow-up at the field level and the need for a multifaceted communications strategy is important for helping push the project forward. Conclusions Burkina Faso’s well-established and effective cotton selling system laid the foundation for the implementation of the Bt cotton project – particularly, the strong dialogue and the receptivity to collaboration. Interviewees reported that establishing and maintaining trust among partners, researchers and the community in Burkina Faso greatly contributed to the success of the PPP. By addressing challenges to building trust and engaging in trust-building practices early on, improvements in the effectiveness of agbiotech PPPs are likely.

  17. К вопросу о совершенствовании проверки коммуникативной компетенции в различных системах тестирования (Cambridge ESOL и ТРКИ)

    OpenAIRE

    Магомедова, М.

    2007-01-01

    В данной статье рассматривается проблема тестирования коммуникативной компетенции в Cambridge ESOL и ТРКИ. Сопоставляются уровни Совета Европы, Кембриджского экзаменационного синдиката и российской государственной системы тестирования. Даётся представление о формате и содержании экзаменов и принципиальные отличия в их проведении и оценке....

  18. Locating Gender: Occupational Segregation, Wages and Domestic Responsibilities. Cambridge Studies in Work and Social Inequality 1.

    Science.gov (United States)

    Siltanen, Janet

    This text combines a case-study approach with significant theoretical development to challenge existing explanations of occupational segregation. Chapter 1 reviews issues raised by the conceptual status of "gender" in attempting to explain women's and men's employment experience and introduces the study that forms the core of the…

  19. Das Weibchen von Erigonoplus justus (O. P.-Cambridge, 1875 (Araneae: Linyphiidae

    Directory of Open Access Journals (Sweden)

    Thaler, Konrad

    2001-04-01

    Full Text Available The rare erigonine Erigonoplus justus was recently discovered at a xerothermic site in Rheinland-Pfalz. Its female is described for the first time. The species is new for Germany. Habitat preference, phenology and distribution area of E. justus are briefly discussed.

  20. EPA-0533 - Psychopathology and aging: executive function performance on the cambridge neuropsychological test automated battery (CANTAB)

    NARCIS (Netherlands)

    Egger, J.I.M.; Janssen, G.T.L.; Aken, L. van

    2014-01-01

    Introduction Early detection of cognitive change is essential for the diagnosis and timely onset of treatment in a variety of neuropsychiatric disorders. Since changes in executive function (EF) are contingent upon age and may compromise assessment accuracy, psychiatric patients and normal controls

  1. The factors influencing car use in a cycle-friendly city: the case of Cambridge

    OpenAIRE

    Carse, Andrew; Goodman, Anna; Mackett, Roger L.; Panter, Jenna; Ogilvie, David

    2013-01-01

    Encouraging people out of their cars and into other modes of transport, which has major advantages for health, the environment and urban development, has proved difficult. Greater understanding of the influences that lead people to use the car, particularly for shorter journeys, may help to achieve this. This paper examines the predictors of car use compared with the bicycle to explore how it may be possible to persuade more people to use the bicycle instead of the car. Multivariable logistic...

  2. Air Force Cambridge Research Laboratories Report on Research, July 1972 - June 1974

    Science.gov (United States)

    1975-05-01

    June 1972 to June 1974 three major Orbitaldragdensitydepartures frointheJac- field experiments- were carried out to de- chia 1971 models for Musket Ball...Nonlinear Transmission of EM Waves Through a Difftusing (19 September 1973) Chemically Seeded Reenty Plasma Fall USNC/URSI Mtg., Williamsburg, Va...riometer absorp- network of railways. The large bright spots tion. Since absorption, optical and-particle surrounded by halos are oil well burn-offs

  3. Chronology: From the Cambridge Field Station to the Air Force Geophysics Laboratory, 1945-1985

    Science.gov (United States)

    1985-09-06

    Strawberry Hill test site in Concord, Massachusetts. (It was dismantled in December 1964.) 1964 .Jan AFCRL placed its newly developed laser...NStrkOPI Infrared Physics B D SC-hurn LCA Balloon Design & Flight A 0 Korn A nalys is LCC Balloon instrumenttation R J Covve HCA Sumn AoktE F McKenna...Strategic Defense Initiative (SDI), 83. Stratospheric Environment Program, 61, 65, 78. Strawberry Hill site, Concord, Massachusetts, 28. Summer St

  4. Ingestion of phosphorus-32 at Massachusetts Institute of Technology, Cambridge, Massachusetts, identified on August 19, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    On Monday, October 16, 1995, the Massachussetts Institue of Technology (MIT, the licensee) notified the US Nuclear Regulatory Commission (NRC) of an incident involving ingestion of phosphorus-32 by a researcher at the MIT Center for Cancer Research. The licensee informed the NRC that a researcher had reported the incident on August 19. The licensee initially estimated the intake as 500 microcuries (19 MBq) and the dose as 4000 millirem (40 mSv) to the individual. On October 12, the licensee informed the researcher that its final intake estimate was 579 microcuries (21 MBq), just under the 600 microcuries (22 MBq) which would represent an overexposure. On October 17, the NRC established an Incident Investigation Team to investigate the case. NRC also contracted with Lawrence Livermore National Laboratory and Oak Ridge Institute for Science and Education to do independent dose assessments of the urine sample data and the whole-body data. The Team concluded that the licensee`s final intake and dose estimates were in accordance with accepted scientific references and NRC guidance. However, recognizing the uncertainties involved in the use of models to simulate human characteristics, the Team determined the intake would be better characterized as likely falling within a range of 500 to 750 microcuries (19--28 NMq). An NRC medical consultant concluded that no symptoms or acute effects should be observed from an intake of this level.

  5. Herman Paul. (2011. Hayden White: The Historical Imagination. Cambridge: Polity Press [204 pp.

    Directory of Open Access Journals (Sweden)

    Ariel C. Lopez

    2011-12-01

    Full Text Available Ang akdang ito ni Herman Paul ay isang kritikal na pagsasakasaysayan(historicization ng mga ideya ni Hayden White na maibibilang sapinakamahahalagang pilosopo ng kasaysayan ng kontemporaryong panahon.Si White ay tanyag bilang simbolo par excellence ng postmodernistang kasaysayan na reaksyon laban sa noo’y, at hanggang ngayo’y, namamayaning positibistang pananaw (na inuugat sa Alemang historyador ng ika-19 na dantaon na si Leopold von Ranke. Noong Dekada ’50 pa lang, masusulyapan na ang pagsalungat ni White sa tradisyong positibista nang tawagin niya si Ranke bilang “kawawang nilalang na nagkandabulag sa paghahanap ng ‘kung ano ang tunay na nangyari’”(Paul, 2011, p.105. Para kay White, ang nakaraan per se (bilang nakaraan ay isang “walang-kahulugang katotohanan” (meaningless reality lamang. Binibigyang kahulugan ng mga historyador ang nakaraan sa pamamagitan ng mga naratibo na siyang humuhugis at nagtatakda sa kahulugan. Sa magnum opus ni White na pinamagatang Metahistory: The Historical Imagination in Nineteenth-Century Europe (1973, inilalatag niya ang ibat-ibang pagbabanghay (emplotment at tropos (tropesna implisitong sinusundan at sinasandigan ng mga (positibistang historyador upang magkaroon ng makatotohanang naratibo.

  6. The Impact of Cambridge and the Determination of Fair Use in Educational Settings

    Science.gov (United States)

    Shields, Timothy D.

    2016-01-01

    The Fair Use exemption to copyright infringement is a difficult concept for those within the legal community because of its unique "case-by-case" application. Without any red line rules, providing guidance to typical users is even more challenging. This paper reviews several recent cases regarding the application of Fair Use and how the…

  7. How Do Different Types of Schools Prepare Students for Life at Cambridge?

    Science.gov (United States)

    Perez-Adamson, Clara; Mercer, Neil

    2016-01-01

    Twenty students from different educational backgrounds within the UK were interviewed to investigate how well they considered their secondary school education had prepared them for the educational and social demands of an "elite" university and life within its most traditional colleges. The study asked them how they perceived students…

  8. Reflections on Cambridge: M R James and Ghosts - James' portrait in King's College

    OpenAIRE

    Macfarlane, Alan

    2012-01-01

    .mp4 video file 2012 is the 150th anniversary of of MR James the famous ghost story writers' birth - he will be on the first class stamp. As a very distant descendant of James, but, like him, a Fellow of King's, Alan Macfarlane tells us something about James Filmed in 2009 by Xu Bei

  9. Grammatical objections to the International Rules of Botanical Nomenclature, adopted at Cambridge in 1930

    NARCIS (Netherlands)

    Danser, B.H.

    1935-01-01

    It is generally known that botanical nomenclature, though sprung from mediaeval scientific Latin, and agreeing, in its orthography for the greater part, in its grammar as much as possible, with classical Latin, shows countless forms which not only from a classical-grammatical, but also from a

  10. RESENHA DESCRITIVA - Cambridge Handbook of Strategy-as-Practice v.1

    OpenAIRE

    Marcio Luiz Marietto

    2016-01-01

    Desde o artigo seminal de Whittington (1996) propondo que os estudos em Estratégia Organizacional levassem em consideração a estratégia do ponto de vista sociológico, em detrimento somente ao ponto de vista econômico, a abordagem da Estratégia como Prática (S-as-P), no exterior, parece estar se consolidado. A prova da robustez destes estudos encontra-se no primeiro volume do Handbook de Estratégia como Prática lançado em 2010. O livro, mais do que detalhar estudos passados forneceu (além das ...

  11. RESENHA DESCRITIVA - Cambridge Handbook of Strategy-as-Practice v.1

    Directory of Open Access Journals (Sweden)

    Marcio Luiz Marietto

    2016-12-01

    Full Text Available Desde o artigo seminal de Whittington (1996 propondo que os estudos em Estratégia Organizacional levassem em consideração a estratégia do ponto de vista sociológico, em detrimento somente ao ponto de vista econômico, a abordagem da Estratégia como Prática (S-as-P, no exterior, parece estar se consolidado. A prova da robustez destes estudos encontra-se no primeiro volume do Handbook de Estratégia como Prática lançado em 2010. O livro, mais do que detalhar estudos passados forneceu (além das direções ontológicas, teóricas e metodológicas perspectivas alternativas para a expansão e o desenvolvimento futuro da área. Todavia, os estudos da S-as-P na América Latina e, em especial, no Brasil parecem, ainda, encontrar dificuldades de compreensão das propostas da abordagem. Desta forma, com o objetivo de contribuir para uma melhor compreensão dos pressupostos ontológicos, teóricos e metodológicos para o aumento da qualidade das futuras pesquisas Brasileiras e Latino Americanas na S-as-P, devido ao alcance internacional da RIAE, optou-se pela realização de uma resenha descritiva, também conhecida como resenha resumo, do conteúdo do Handbook. Para melhor direcionar este objetivo não foi realizada a resenha da última parte (Parte IV do livro. Esta seção mostra exemplos de estudos empíricos realizados na área da S-as-P. Também, existe a intenção futura de se realizar a resenha descritiva do segundo volume do Handbook de Estratégia como Prática publicado em 2015.

  12. Seismic profile analysis of sediment deposits in Brownlee and Hells Canyon Reservoirs near Cambridge, Idaho

    Science.gov (United States)

    Flocks, James; Kelso, Kyle; Fosness, Ryan; Welcker, Chris

    2014-01-01

    The U.S. Geological Survey (USGS) St. Petersburg Coastal and Marine Science Center, in cooperation with the USGS Idaho Water Science Center and the Idaho Power Company, collected high-resolution seismic reflection data in the Brownlee and Hells Canyon Reservoirs, in March of 2013.These reservoirs are located along the Snake River, and were constructed in 1958 (Brownlee) and 1967 (Hells Canyon). The purpose of the survey was to gain a better understanding of sediment accumulation within the reservoirs since their construction. The chirp system used in the survey was an EdgeTech Geo-Star Full Spectrum Sub-Bottom (FSSB) system coupled with an SB-424 towfish with a frequency range of 4 to 24 kHz. Approximately 325 kilometers of chirp data were collected, with water depths ranging from 0-90 meters. These reservoirs are characterized by very steep rock valley walls, very low flow rates, and minimal sediment input into the system. Sediments deposited in the reservoirs are characterized as highly fluid clays. Since the acoustic signal was not able to penetrate the rock substrate, only the thin veneer of these recent deposits were imaged. Results from the seismic survey indicate that throughout both of the Brownlee and Hells Canyon reservoirs the accumulation of sediments ranged from 0 to 2.5 m, with an average of 0.5 m. Areas of above average sediment accumulation may be related to lower slope, longer flooding history, and proximity to fluvial sources.

  13. Chemistry of fossil fuels and biofuels (cambridge series in chemical engineering)

    CERN Document Server

    Schobert, Harold

    2013-01-01

    Focusing on today's major fuel resources - ethanol, biodiesel, wood, natural gas, petroleum products and coal - this book discusses the formation, composition and properties of the fuels, and the ways in which they are processed for commercial use. The book examines the origin of fuels through natural processes such as photosynthesis and the geological transformation of ancient plant material; the relationships between their composition, molecular structures, and physical properties; and the various processes by which they are converted or refined into the fuel products appearing on today's market. Fundamental chemical aspects such as catalysis and the behaviour of reactive intermediates are presented, and global warming and anthropogenic carbon dioxide emissions are also discussed. The book is suitable for graduate students in energy engineering, chemical engineering, mechanical engineering and chemistry, as well as professional scientists and engineers.

  14. Integrating Landscape Ecology into Natural Resource Management - Series: Cambridge Studies in Landscape Ecology

    Science.gov (United States)

    Jianguo Liu, Edited By; Taylor, William W.

    2002-08-01

    The rapidly increasing global population has dramatically increased the demands for natural resources and has caused significant changes in quantity and quality of natural resources. To achieve sustainable resource management, it is essential to obtain insightful guidance from emerging disciplines such as landscape ecology. This text addresses the links between landscape ecology and natural resource management. These links are discussed in the context of various landscape types, a diverse set of resources and a wide range of management issues. A large number of landscape ecology concepts, principles and methods are introduced. Critical reviews of past management practices and a number of case studies are presented. This text provides many guidelines for managing natural resources from a landscape perspective and offers useful suggestions for landscape ecologists to carry out research relevant to natural resource management. In addition, it will be an ideal supplemental text for graduate and advanced undergraduate ecology courses. Written, and rigorously reviewed, by many of the world's leading landscape ecologists and natural resource managers Contains numerous case studies and insightful guidelines for landscape ecologists and natural resource managers

  15. Calentamiento local: Cambridge, MA, Estados Unidos / Venecia, Italia, MIT Senseable City Lab, 2014

    OpenAIRE

    Ratti, Carlo; Claudel, Matthew

    2015-01-01

    Si gran parte de la energía utilizada en calefaccionar los recintos se pierde, ¿qué pasa si en vez de calentar el aire de los espacios nos enfocamos en dirigir el calor hacia las personas que se mueven en ellos? En medio de la discusión sobre el ‘calentamiento global’, Calentamiento Local nos invita a cambiar el eje de la discusión, proponiendo una alternativa basada en la focalización de la energía calórica.

  16. Biotechnology Conference: Diagnostics 󈨛 Held in Cambridge, England on 10 and 11 December 1987.

    Science.gov (United States)

    1988-05-25

    proteins are figure. numerous and vary widely in concentration. In thc EK- TACHEM process developed at Kodak for assaying the smaller inorganic ions...use pregnancy and fertility small bilbulous paper strip (15.5 x 1 x 0.1 cm) on which testing. In this respect, four basic types of heterogeneous...migrate along the strip, reacting as they do so in a soluble horse radish peroxidase (HRP)-labeled anti- predetermined manner. Some 10 minutes later, a

  17. RESENHA DESCRITIVA - Cambridge Handbook of Strategy-as-Practice v.1

    National Research Council Canada - National Science Library

    Marcio Luiz Marietto

    2016-01-01

      Since the seminal paper by Whittington (1996) proposed that the studies in Organizational Strategy consider the strategy by the sociological view, rather than only the economic view, the approach of the Strategy as Practice (S-as-P...

  18. International Symposium on Wind Energy Systems, Held at Cambridge University, on 7-9 September 1976

    Science.gov (United States)

    1976-12-07

    turbine rotor. Pararmters are the number of blades , the tip speed ratio (tip speed/ wind speed), and the lift/drag ratio of the rotor airfoil sections... blades . The concept of the VGVAW was quite favorably received by the Conference delegates, and its compactness (relative to the Darrieus turbine ... wind energy available ia the vicinity of the turbine blades . Several similarities could be seen between the various concept--, partic- ularly those

  19. Ricordi e riflessioni di un patriota australiano e di un economista di Cambridge

    Directory of Open Access Journals (Sweden)

    G.C. HARCOURT

    2013-10-01

    Full Text Available The paper is a contribution to a series of recollections and reflections on the professional experiences of distinguished economists which the Banca Nazionale del Lavoro Quarterly Review started in 1979. Hargourt describes is becoming an economist and subsequent academic life as a “Christian socialist”.  JEL Codes: A10, B31Keywords: Hargourt, Christian, Socialist, Australian, Recollections

  20. Ricordi e riflessioni di un patriota australiano e di un economista di Cambridge

    Directory of Open Access Journals (Sweden)

    G.C. HARCOURT

    1995-09-01

    Full Text Available The paper is a contribution to a series of recollections and reflections on the professional experiences of distinguished economists which the Banca Nazionale del Lavoro Quarterly Review started in 1979. Hargourt describes is becoming an economist and subsequent academic life as a “Christian socialist”.

  1. Art, Science and the Invention of Things That Last

    KAUST Repository

    Edwards, David

    2018-01-14

    Aesthetic creation involves a close collaboration between discovery, invention and cultural exhibition, as well as between learning and producing value. It is typified by the patterns of creative behavior in highly innovative communities like Silicon Valley (for IT) or Boston (for biotech) where cultures of learning, experimentation, and production or commercialization coexist, and where a high degree of interdisciplinary collaboration occurs. In this lecture, David Edwards will highlight the growing movement of aesthetic creation in the arts, sciences and engineering as a path for sustaining and improving the human condition in the longest term. He will highlight aesthetic creation in the light of the culture lab model of Le Laboratoire (Paris, Cambridge) and the new World Frontiers Forum with examples of learning, pubic experimentation and value creation particularly related to the future of sensory experience.

  2. Scancell's vaccine SCIB1 could help to prevent recurrence of melanoma.

    Science.gov (United States)

    Goodfellow, Richard

    2015-01-01

    Interviewed by Ellen Clarke (Commissioning Editor, Future Science Group). Richard Goodfellow is Joint-CEO of Scancell Holdings plc, a public company listed on the London Stock Exchange. He has over 25 years international experience in the pharmaceutical industry, in Big Pharma and with Biotech companies. During his time at Astra, he oversaw the launch of Losec and other key products internationally. Thereafter, he held the post of Director of Licensing and New Business Development at Scotia Pharmaceuticals, where he was involved with the company's flotation on the London Stock Exchange and successfully negotiated numerous deals. Goodfellow is also a founder of Paradigm Therapeutics, a Cambridge-based functional genomics company and is a former Director of Enact Pharma plc.

  3. Collaborative pre-competitive preclinical drug discovery with academics and pharma/biotech partners at Sanford|Burnham: infrastructure, capabilities & operational models.

    Science.gov (United States)

    Chung, Thomas D Y

    2014-03-01

    There has been increased concern that the current "blockbuster" model of drug discovery and development practiced by "Big Pharma" are unsustainable in terms of cost (> $1 billion/approved drug) and time to market (10 - 15 years). The recent mergers and acquisitions (M&A), shuttering of internal research programs, closure of "redundant" sites of operations, senior management turnover and continued workforce reductions among the top 10 major pharmaceutical companies reflect draconian responses to reduce costs. However, the resultant exodus of intellectual capital, loss in motivation and momentum, and exit from early stage discovery programs by pharmaceutical companies has contributed to an "innovation deficit". Disease advocacy groups, investment communities and the government are calling for new innovative business models to address this deficit. In particular they are looking towards academia and clinical trials centers to catalyze new innovations in translational research. Indeed over the last decade many academic institutions have launched drug discovery centers largely comprising high-throughput screening (HTS) to accelerate "translational" research. A major impetus for this "open innovation" effort has been the National Institutes of Health (NIH) "Roadmap" and Molecular Libraries Initiative/Program (MLI/MLP), which is in its last year, and will be transitioned into the National Center for the Advancement of Translational Sciences (NCATS). With the end of Roadmap funding, general reduction in Federal government funding and its recent sequestration, academic drug discovery centers are being challenged to become selfsustaining, adding financial value, while remaining aligned with the missions of their respective academic non-profit institutions. We describe herein, a brief history of our bi-coastal Conrad Prebys Center for Chemical Genomics (Prebys Center) at the Sanford|Burnham Medical Research Institute (SBMRI), the key components of its infrastructure, core competencies of its fully integrated drug discovery expertise, best practices adopted in our day-to-day operations, and finally some of our current funding and collaboration and/or strategic alliance models for pre-competitive drug discovery with other academic/clinical partners, other governmental agencies, and with pharmaceutical and biotechnology companies.

  4. The impact of patent eligibility on biotech patents: A flow chart for determining patent eligibility and an immune therapy case study

    Science.gov (United States)

    Chang, Bao-Chi; Wang, Shyh-Jen

    2015-01-01

    US common law recites a natural law, natural phenomenon or abstract idea as exceptions to the 4 statutory patentable categories to guard against the wholesale preemption of fundamental principles. The very recent evolutions of patent exceptions in the US may increase the difficulty of patenting and may create uncertainty in determining patent eligibility. To solve the thorny problem of eligibility, this study presents a flow chart based on the courts’ decisions that can serve as a set of guidelines for determining patent eligibility. A case related to prostate cancer immune therapy is presented for discussion. PMID:25714661

  5. Judicial activism, the Biotech Directive and its institutional implications – Is the Court acting as a legislator or a court when defining the ‘human embryo’?

    DEFF Research Database (Denmark)

    Faeh, Andrea Beata

    2015-01-01

    a number of questions about the limits to the Court’s jurisdiction and whether was acting as a legislator rather than in a judicial capacity. As a consequence of the Court’s judicial activism, biotechnological inventions manoeuvre in a new, more restrictive legal environment than before. However......-fertilised human ovum, not capable of developing into a human being, is not a ‘human embryo’. Hence, ‘where a non-fertilised human ovum does not fulfil that condition [inherent capacity of developing into a human being], the mere fact that that organism commences a process of development is not sufficient...

  6. Where to implement local biotech innovations? A framework for multi-scale socio-economic and environmental impact assessment of Green Bio-Refineries

    DEFF Research Database (Denmark)

    Cong, Ronggang; Stefaniak, Irena; Madsen, Bjarne

    2017-01-01

    Green Bio-Refineries (GBRs) have economic and environmental potentials through changing land use from cereals to grass production and provision of grass-based protein feed for livestock production and other valuable byproducts. However, the potentials are dependent on local conditions of the GBRs...... by sketching out priority areas for developing GBRs and discuss the policy implications of the results within the context of development of a bio-based economy....

  7. Beyond regional clusters: On the importance of geographical proximity for R&D collaborations in a global economy - the case of the flemisch biotech sector

    NARCIS (Netherlands)

    Herrmann, A.M.; Taks, J.L.; Moors, E.H.M.

    2012-01-01

    When internal knowledge bases are insufficient for developing innovations, companies tend to collaborate with external R&D partners. According to a long-standing literature on “clusters”, “industrial districts”, “local production systems” and “regional innovation systems”, geographical proximity

  8. Sectoral Innovatiohn Performance in the Biotechnology Sector. Final Report. Task 1

    NARCIS (Netherlands)

    Enzing, C.M.; Valk, T. van der

    2010-01-01

    In general the biotechnology sector can be qualified as a science driven and high tech sector. This applies for both the group of biotech start-ups that are present in each of the three sub-sectors (red biotech: health/pharma, green biotech: agrifood and white biotech: chemicals) as for the red

  9. Richard Seaford. Cosmology and the polis. The social construction of space and time in the tragedies of Aeschylus : Cambridge University Press, Cambridge, 2012, xiii + 366 pp.

    OpenAIRE

    Fernández Deagustini, María del Pilar

    2013-01-01

    Richard Seaford es profesor de griego antiguo en la Universidad de Exeter. Su trabajo sobre la tragedia y la religión griegas lo ha llevado a investigar las condiciones históricas para el desarrollo radical de la cultura griega en el siglo VI a. C. y a proponer que el factor crucial de este desarrollo ha sido el dinero, dado que la polis de este período fue la primera sociedad monetizada de la historia. En la presente publicación, en la que Seaford sintetiza estos y otros reconocidos trabajos...

  10. Book Review: Unifying scientific theories: physical concepts and mathematical structures. Margaret Morrison, Cambridge University Press, Cambridge, 2000, pp. 280, US 65.00, ISBN 0-521-65216-2 hardback

    Science.gov (United States)

    Debs, Talel A.

    In addition to being a thorough and timely treatment of unity in science, Morrison's book is particularly noteworthy for the kind of inquiry it represents. In the context of current debates in the history and philosophy of science, Morrison has managed to chart a very persuasive middle path through potentially contentious extreme positions. Also, by taking an approach that is at once conceptual and historical, she has produced a book that truly addresses both the history and philosophy of modern science; it allows the reader to interact with key philosophical questions in addition to well researched and well documented historical accounts. These accounts, which function as case studies, are provided in Chapters 3-6. They are valuable both in-and-of themselves, and as examples which illustrate Morrison's main philosophical thesis.

  11. Precaution, bioethics and normative justification: Daniel Steel: Philosophy and the precautionary principle: science, evidence and environmental policy. Cambridge University Press, Cambridge, 2015, xv + 256 pp, ISBN 978-1-107-07816-1

    National Research Council Canada - National Science Library

    Munthe, Christian

    2015-01-01

    Daniel Steel’s new book on the precautionary principle illustrates the need to work ahead to fuse perspectives of epistemology and philosophy of science with those of ethics to accomplish progress in the debate...

  12. Austin Jennifer, Blume María, & Sánchez Liliana (2015. Bilingualism in the Spanish-speaking world: linguistic and cognitive perspectives. Cambridge, United Kingdom: Cambridge University Press.

    Directory of Open Access Journals (Sweden)

    Maria I. Fionda

    2015-12-01

    Full Text Available The book reviewed here may serve as an excellent resource for advanced undergraduate students of linguistics, as well as graduates and scholars in the field and related disciplines. It comprises five chapters that explore, through three Spanish bilingual communities, the following topics: basic concepts in bilingualism, such as code-switching and language transfer; a brief historical review of Spanish bilingualism; proposed definitions of bilingualism and the different ways in which bilinguals may be classified according to factors such as language competence and age of acquisition; the effect of bilingualism on the brains and minds of bilingual speakers, such as increased cortical activation and enhanced literacy; and, finally, the development and outcomes of bilingualism on the linguistic representations of bilingual speakers. The authors cover a breadth of research, rendering it accessible by succinctly reviewing findings, and further identify areas for future research.

  13. Sensor fusion: Spatial reasoning and scene interpretation; Proceedings of the Meeting, Cambridge, MA, Nov. 7-9, 1988

    Science.gov (United States)

    Schenker, Paul S. (Editor)

    1989-01-01

    The present conference discusses topics in the fusion of active and passive sensors, object estimation and verification, three-dimensional representation and knowledge integration, three-dimensional perception from multisensor data, the representation of uncertainty in multisensor fusion, and sensor calibration and registration. Also discussed are the areas of multisensor target detection and classification, multisensor processing architectures, knowledge structures and spatial reasoning, sensory interfaces to telerobotic systems, and navigation with spatial data bases.

  14. A Workshop on Environmental Technology Assessment Held at the University of Cambridge, England Held on 24-26 April, 1985,

    Science.gov (United States)

    1985-01-01

    ard NO/S reoa in the Federal Republic of Germany /O reoa * Vendor/ Process System License! * Developer * Deutsche Babcock Kawasaki Selective catalytic...waters have some influence on the incidence of certain forms of cardiovascular disease the use of softening for domestic supplies may we decline...It is generally believed that competitive markets, devoid of government regulations, can produce efficient (i.e., Pareto optimal) outcomes

  15. International Congress on High-Speed Photography and Photonics, 19th, Cambridge, England, Sept. 16-21, 1990, Proceedings

    Science.gov (United States)

    Garfield, Brian R.; Rendell, John T.

    1991-04-01

    The present conference discusses the application of schlieren photography in industry, laser fiber-optic high speed photography, holographic visualization of hypervelocity explosions, sub-100-picosec X-ray gating cameras, flash soft X-radiography, a novel approach to synchroballistic photography, a programmable image converter framing camera, high speed readout CCDs, an ultrafast optomechanical camera, a femtosec streak tube, a modular streak camera for laser ranging, and human-movement analysis with real-time imaging. Also discussed are high-speed photography of high-resolution moire patterns, a 2D electron-bombarded CCD readout for picosec electrooptical data, laser-generated plasma X-ray diagnostics, 3D shape restoration with virtual grating phase detection, Cu vapor lasers for high speed photography, a two-frequency picosec laser with electrooptical feedback, the conversion of schlieren systems to high speed interferometers, laser-induced cavitation bubbles, stereo holographic cinematography, a gatable photonic detector, and laser generation of Stoneley waves at liquid-solid boundaries.

  16. Rezension zu: Nicole C. Karafyllis, Gotling Ulshöfer: Sexualized Brains. Cambridge u.a.: MIT Press 2008

    Directory of Open Access Journals (Sweden)

    Sigrid Schmitz

    2009-07-01

    Full Text Available In der Auseinandersetzung um geschlechtliche Normierungen spielt die moderne Hirnforschung eine wirkmächtige und inzwischen disziplinenübergreifende Rolle. Nicole Karafyllis und Gotlind Ulshöfer stellen in diesem Sammelband mit Beiträgen aus Neurowissenschaft, Psychologie, Soziologie, Kulturwissenschaft und Philosophie ein multiperspektivisches Diskursfeld zu der Frage vor, ob die Emotionale Intelligenz (EI als erstrebenswerte Fähigkeit die klassische Kodierung in männliche Rationalität bzw. weibliche Emotionalität dekonstruieren und ein emanzipatorisches Potential entgegen gesellschaftlichen Hierarchisierungen entfalten kann. Viele Aspekte, Verbindungen zwischen den Diskurssträngen und wechselseitige Beeinflussungen, aber auch disziplinäre Eingrenzungen werden sichtbar, die eine kritische Fortführung des hier angestoßenen Dialogs notwendig machen.

  17. EU External Relations Law: Text, Cases and Materials, Bart Van Vooren and Ramses A. Wessel, Cambridge University Press, UK, 2014

    DEFF Research Database (Denmark)

    Butler, Graham

    2014-01-01

    by the Treaties, and it is suitably placed to become the core text for teaching this expanding EU policy field. In their book, EU External Relations Law: Text, Cases and Materials, Van Vooren and Wessel seek to fill the gap in up-to-date literature from a legal standpoint in the field of external relations...

  18. Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: results from the Cambridge Breast IMRT trial.

    Science.gov (United States)

    Mukesh, Mukesh B; Qian, Wendi; Wilkinson, Jennifer S; Dorling, Leila; Barnett, Gillian C; Moody, Anne M; Wilson, Charles; Twyman, Nicola; Burnet, Neil G; Wishart, Gordon C; Coles, Charlotte E

    2014-05-01

    The use of intensity-modulated radiotherapy (IMRT) in breast cancer reduces clinician-assessed breast tissue toxicity including fibrosis, telangectasia and sub-optimal cosmesis. Patient reported outcome measures (PROMs) are also important as they provide the patient's perspective. This longitudinal study reports on (a) the effect of forward planned field-in-field IMRT (∼simple IMRT) on PROMs compared to standard RT at 5 years after RT, (b) factors affecting PROMs at 5years after RT and (c) the trend of PROMs over 5 years of follow up. PROMs were assessed at baseline (pre-RT), 6, 24 and 60 months after completion of RT using global health (EORTC QLQ C30) and 4 breast symptom questions (BR23). Also, 4 breast RT-specific questions were included at 6, 24 and 60 months: change in skin appearance, firmness to touch, reduction in breast size and overall change in breast appearance since RT. The benefits of simple IMRT over standard RT at 5 years after RT were assessed using standard t-test for global health and logistic regression analysis for breast symptom questions and breast RT-specific questions. Clinical factors affecting PROMs at 5 years were investigated using a multivariate analysis. A repeated mixed model was applied to explore the trend over time for each of PROMs. (89%) 727/815, 84%, 81% and 61% patients completed questionnaires at baseline, 6, 24 and 60 months respectively. Patients reported worse toxicity for all four BR23 breast symptoms at 6 months, which then improved over time (pappearance and breast hardness over time (pappearance (p=0.13). At 5years, PROMs assessments did not demonstrate a benefit for simple IMRT over standard radiotherapy. Large breast volume, young age, baseline surgical cosmesis and post-operative infection were the most important variables to affect PROMs. This study was unable to demonstrate the benefits of IMRT on PROMs at 5years. PROMs are influenced by non-radiotherapy factors and surgical factors should be optimised to improve patients' outcome. Only a small proportion of patients report moderate-severe breast changes post radiotherapy, with most PROMs improving over time. The difference in clinician assessment and PROMs outcome requires further investigation. Crown Copyright © 2014. Published by Elsevier Ireland Ltd. All rights reserved.

  19. Book Review - V Pogoretskyy, Freedom of Transit and Access to Gas Pipeline Networks Under WTO Law (Cambridge University Press, 2017)

    NARCIS (Netherlands)

    Marhold, Anna

    2017-01-01

    In Freedom of Transit and Access to Pipeline Networks under WTO Law, the author appropriately introduces the topic by stating that energy is featuring increasingly prominently as a topic in international trade law. Indeed, while being a dormant issue in the World Trade Organization (“WTO” forum for

  20. Unified Airport Pavement Design and Analysis Concepts Workshops Held in Cambridge, Massachusetts on 16-17 July 1991

    Science.gov (United States)

    1992-07-01

    researcher but have noa been used extensively for airpor pavemen analysis. Finally, thet are wodels that have been devope in otr egb elds tha c be applied...traffic &=-as spxectively. Design chain are ptesented for singmeo dual and dual-tandem gear types The manual nrses wthe us of the PCA pavment design...stochastic fracturing process is used by Krausz and Krausz [66]. The process 11 &d riibed mathematically through the Markov chain concept or the Fokker

  1. Proceedings of the Critical Review: Techniques for the Characterization of Composite Materials, held Cambridge, Massachusetts, 8-10 June 1981.

    Science.gov (United States)

    1982-05-01

    pp. 169-172. 11. D. R. Jones, International Journal of Heat and Mass Transfer, 17, 11-21 (1974). 12. D. K. Gartling, "NACHOS - A rinite Element...heterogeneous materials such soil, concrete, paper and food products. (5 ) It is known that in composites, moisture can exist in variou4 states including

  2. H. VAN RIEMSDIJK AND EDWIN WILLIAMS, /ntroduction to the Theory of Grammar, Cambridge. (The MIT Press 1986, xvi + 366 pp.

    Directory of Open Access Journals (Sweden)

    Mario Montalbetti

    1987-06-01

    Full Text Available Con la publicación en 1981 de sus Lectures on Government and Binding (Dordrecht, Foris Noam Chomsky inauguró (al menos editorialmente ya que las ideas se venían discutiendo hacía dos o tres años el nuevo modelo generativo.Este nuevo modelo (denominado GB, las iniciales de los dos procesos aludidos en el título del libro de Chomsky supone un cambio fundamental de enfoques y concepción de la teoría gramatical respecto de los modelos generativos anteriores.

  3. H. VAN RIEMSDIJK AND EDWIN WILLIAMS, /ntroduction to the Theory of Grammar, Cambridge. (The MIT Press) 1986, xvi + 366 pp.

    OpenAIRE

    Mario Montalbetti

    1987-01-01

    Con la publicación en 1981 de sus Lectures on Government and Binding (Dordrecht, Foris) Noam Chomsky inauguró (al menos editorialmente ya que las ideas se venían discutiendo hacía dos o tres años) el nuevo modelo generativo.Este nuevo modelo (denominado GB, las iniciales de los dos procesos aludidos en el título del libro de Chomsky) supone un cambio fundamental de enfoques y concepción de la teoría gramatical respecto de los modelos generativos anteriores.

  4. Applications of GIS for highway safety : peer exchange summary report, Cambridge, MA, September 14-15, 2011

    Science.gov (United States)

    2011-09-30

    On September 14-15, 2011, the FHWA's Office of Planning and its Office of Safety sponsored a 1.5-day peer exchange to promote the use of GIS and mapping for highway safety applications. This report offers overviews of the presentations given at the p...

  5. Pain reporting in older adults: the influence of cognitive impairment - results from the Cambridge City >75 Cohort study.

    Science.gov (United States)

    Docking, Rachael E; Fleming, Jane; Brayne, Carol; Zhao, Jun; Macfarlane, Gary J; Jones, Gareth T

    2014-08-01

    Evidence suggests that while disabling back pain (BP), and rheumatic diseases associated with pain, continues to increase with age, the prevalence of non-disabling BP reaches a plateau, or even decreases, in the oldest old. This study aimed to determine whether this age-related pattern of non-disabling BP is a function of increasing cognitive impairment. Cross-sectional study of adults aged >77 years. Participants answered interviewer-administered questions on BP and cognitive function, assessed using the Mini-Mental State Examination, categorised into normal versus mild, moderate or severe impairment. The relationship between cognitive function and BP was examined using multinomial logistic regression, adjusted for age, sex and residence. Of 1174 participants with BP data, 1126 (96%) completed cognitive assessments. The relationship between cognitive function and BP differed for disabling and non-disabling BP. Across categories of cognitive impairment, increasingly higher prevalence of disabling BP was reported, compared to those with normal cognition, although this was not statistically significant (odds ratio (OR) = 1.7; 95% confidence interval (CI) = 0.7-4.6). No association was found between cognitive function and non-disabling BP (OR = 0.8; 95% CI = 0.4-1.6). This study found no association between the reporting of BP and level of cognitive impairment, suggesting that increasing cognitive impairment is an inadequate explanation for age-related decline in self-reported non-disabling BP. Future research should determine the reasons for the decline in non-disabling pain in older adults, although, meanwhile, it is important to ensure that this group receive appropriate pain assessment and pain management. Prevalence of non-disabling back pain decreases in the oldest old.Some have proposed that this may be a function of cognitive impairment in older age, and an increasing inability to adequately report pain.Our findings do not support this hypothesis.

  6. Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial

    Science.gov (United States)

    Simmons, Rebecca K; Echouffo-Tcheugui, Justin B; Sharp, Stephen J; Sargeant, Lincoln A; Williams, Kate M; Prevost, A Toby; Kinmonth, Ann Louise; Wareham, Nicholas J; Griffin, Simon J

    2012-01-01

    Summary Background The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, uncertainty persists around the benefits of screening for type 2 diabetes. We assessed the effect of a population-based stepwise screening programme on mortality. Methods In a pragmatic parallel group, cluster-randomised trial, 33 general practices in eastern England were randomly assigned by the method of minimisation in an unbalanced design to: screening followed by intensive multifactorial treatment for people diagnosed with diabetes (n=15); screening plus routine care of diabetes according to national guidelines (n=13); and a no-screening control group (n=5). The study population consisted of 20 184 individuals aged 40–69 years (mean 58 years), at high risk of prevalent undiagnosed diabetes, on the basis of a previously validated risk score. In screening practices, individuals were invited to a stepwise programme including random capillary blood glucose and glycated haemoglobin (HbA1c) tests, a fasting capillary blood glucose test, and a confirmatory oral glucose tolerance test. The primary outcome was all-cause mortality. All participants were flagged for mortality surveillance by the England and Wales Office of National Statistics. Analysis was by intention-to-screen and compared all-cause mortality rates between screening and control groups. This study is registered, number ISRCTN86769081. Findings Of 16 047 high-risk individuals in screening practices, 15 089 (94%) were invited for screening during 2001–06, 11 737 (73%) attended, and 466 (3%) were diagnosed with diabetes. 4137 control individuals were followed up. During 184 057 person-years of follow up (median duration 9·6 years [IQR 8·9–9·9]), there were 1532 deaths in the screening practices and 377 in control practices (mortality hazard ratio [HR] 1·06, 95% CI 0·90–1·25). We noted no significant reduction in cardiovascular (HR 1·02, 95% CI 0·75–1·38), cancer (1·08, 0·90–1·30), or diabetes-related mortality (1·26, 0·75–2·10) associated with invitation to screening. Interpretation In this large UK sample, screening for type 2 diabetes in patients at increased risk was not associated with a reduction in all-cause, cardiovascular, or diabetes-related mortality within 10 years. The benefits of screening might be smaller than expected and restricted to individuals with detectable disease. Funding Wellcome Trust; UK Medical Research Council; National Health Service research and development support; UK National Institute for Health Research; University of Aarhus, Denmark; Bio-Rad. PMID:23040422

  7. Report: 9th International Reflective Practice Conference: Mindful Inquiry: 23-25 June 2003: Robinson College, Cambridge, United Kingdom

    Directory of Open Access Journals (Sweden)

    V J Ehlers

    2003-04-01

    Full Text Available This annual conference is organised by the Institute of Health and Community Studies, Bournemouth University. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  8. DATA SONIFICATION, FROM PHYSICS TO HEALTH - Interview to Domenico Vicinanza and Genevieve Williams, Anglia Ruskin University, Cambridge.

    CERN Multimedia

    2016-01-01

    In this interview, recorded during the 2016 ICTR-PHE conference organized by CERN in Geneva at the International Conference Centre (CICG) in February, Dr. Domenico Vicinanza and Genevieve Williams describe the use of music and sound as tools for scientific investigation, with specific reference to biomedical sciences and show sonifications in action in a practical demonstration carried pout on physicist musician Chiara Mariotti.

  9. Executive Function Deficits in Children with Fetal Alcohol Spectrum Disorders (FASD) Measured Using the Cambridge Neuropsychological Tests Automated Battery (CANTAB)

    Science.gov (United States)

    Green, C. R.; Mihic, A. M.; Nikkel, S. M.; Stade, B. C.; Rasmussen, C.; Munoz, D. P.; Reynolds, J. N.

    2009-01-01

    Background: Chronic prenatal alcohol exposure causes a spectrum of deleterious effects in offspring, collectively termed fetal alcohol spectrum disorders (FASD), and deficits in executive function are prevalent in FASD. The goal of this research was to test the hypothesis that children with FASD exhibit performance deficits in tasks that assess…

  10. The Cambridge Mindreading (CAM) Face-Voice Battery: Testing Complex Emotion Recognition in Adults with and without Asperger Syndrome

    Science.gov (United States)

    Golan, Ofer; Baron-Cohen, Simon; Hill, Jacqueline

    2006-01-01

    Adults with Asperger Syndrome (AS) can recognise simple emotions and pass basic theory of mind tasks, but have difficulties recognising more complex emotions and mental states. This study describes a new battery of tasks, testing recognition of 20 complex emotions and mental states from faces and voices. The battery was given to males and females…

  11. Proceedings of the Image Understanding Workshop (18th) Held in Cambridge, Massachusetts on 6-8 April 1988. Volume 1

    Science.gov (United States)

    1988-04-01

    done in motion analysis, nay- Field models, and attempts to derive a map of the sur- igation, photogrammetry , visual routines and learning, face...object is not translating directly toward the observer, or where the 5.5. Photogrammetry object is rotating as it moves. These relationships can easily be...these data as part of a demonstration in which we to generate sequences of images (i.e., movies ) that correspond to 111 bring together several

  12. Conference on Surfaces of Biomaterials Biotechnology - Biointeractions 󈨛 Held in Cambridge, United Kingdom on 6-8 July 1987

    Science.gov (United States)

    1987-12-15

    that the pathogen*- hvdToxylpripyl) methacrylate ( HPMA ) co- sts of joint sepsis im directly related polymers with adult rot intatfute wan to microbial...faces are surrounded by qxtracellular UK). Copolymers of HPMA containing car- polynaccharides, which form a continuum ionic (trlimthyla=monium chloride...dues into 1251-llabled HPMA copolymers 13 produced less tissue association than NEC were harvested and cultured on observed with the cationic

  13. Steven E. Miller and Dmitri V. Trenin, eds., The Russian Military: Power and Policy, Cambridge, MA: MIT Press, 2004.

    Directory of Open Access Journals (Sweden)

    Mikhail Tsypkin

    2005-10-01

    Full Text Available The Russian military largely went below the radar of Western interest after the disintegration of the Soviet Union.  More than a decade after the creation of the Armed Forces of the Russian Federation, they have become again the object of interest for scholars – this time, both Western and Russian, as demonstrated by the reviewed volume, whose editors assembled a group of extraordinarily knowledgeable experts from Russia and the West.  In his introduction, Steven Miller explains that the purp...

  14. Proceedings of the Image Understanding Workshop (18th) Held in Cambridge, Massachusetts on 6-8 April 1988. Volume 2

    Science.gov (United States)

    1988-04-01

    wiuen hnbgt Atorin Aht Point,,. ) illl,- foal urp’ sate fromn a4 sinle~¢ iniage. Ani imlport;lll[ ( hitrac(’ %.ftor a preliminary global bounding has...Van Hoesen. Prosopagnosia: anatomical basis k e t al of N .rs cieta, 6(l):145tani, 1. and behavioral mechanisms. Neurology , 32:331-341, [Sakata et at

  15. PESC '91 - Annual IEEE Power Electronics Specialists Conference, 22nd, MIT, Cambridge, MA, June 24-27, 1991, Record

    Science.gov (United States)

    1991-07-01

    The present conference discusses a novel microtransformer for use in microswitching converters, a high torque/low-speed switched-reluctance machine, parameter and state estimation in power electronics, a general circuit topology for a multilevel inverter, dc/dc-conversion via saturable induction commutation, a self-oscillating and synchronously rectified dc/dc converter, an HF quasi-square-wave converter, a new family of isolated zero-voltage switched converters, the dual-flow pulse-trimming concept, solid-state reactive power modulation, the harmonic interaction of power systems with static switching, power MOSFETs for reverse conduction, repetitive switching using thyristors, voltage-mode resonant converters, thermal optimization in power electronics, a MOS gate drive with resonant transitions, a real-time estimation of induction-motor rotor time constant, short circuit impedance and leakage in transformer windings, the miniaturization of isolated gate drive circuitry, and one-cycle control of switching converters. (No individual items are abstracted in this volume)

  16. Surveys 2. Eight State-of-the-Art Articles on Key Areas in Language Teaching. Cambridge Language Teaching Surveys.

    Science.gov (United States)

    Kinsella, Valerie, Ed.

    The articles in this volume are an overview of work in a number of subjects and disciplines which contribute to the field of applied linguistics and language teaching. Specifically, they treat universal properties common to all languages, the historical developments and central issues in speech act theory, speech research on the various stages of…

  17. The contribution of media analysis to the evaluation of environmental interventions: the commuting and health in Cambridge study

    National Research Council Canada - National Science Library

    Kesten, Joanna May; Cohn, Simon; Ogilvie, David

    2014-01-01

    .... As part of a natural experimental evaluation of the travel, physical activity and health impacts of the Cambridgeshire Guided Busway, we analysed print and social media discourse and interview data...

  18. The contribution of media analysis to the evaluation of environmental interventions: the commuting and health in Cambridge study.

    Science.gov (United States)

    Kesten, Joanna May; Cohn, Simon; Ogilvie, David

    2014-05-21

    Media content can increase awareness of, and shape interactions with, public health interventions. As part of a natural experimental evaluation of the travel, physical activity and health impacts of the Cambridgeshire Guided Busway, we analysed print and social media discourse and interview data to understand the nature of new transport infrastructure and how it was experienced. Newspaper articles were systematically retrieved from the LexisNexis database and tweets were identified from an online archive. Interviews were conducted as part of the larger evaluation study with 38 adults. Inductive thematic analysis was performed and comparisons were drawn between datasets. The findings are discussed in relation to five themes. First, an understanding of the intervention context and how the intervention was experienced was developed through accounts of events occurring pre and post the busway's opening. Second, the media captured the dynamic nature of the intervention. Third, the media constructed idealised portrayals of the anticipated busway which in some cases were contradicted by the impact of the busway on the existing context and people's lived experiences. Fourth, differential media coverage of the intervention components suggested that a lesser value was placed on promoting active travel compared with public transport. Lastly, interview data provided support for the hypothesis that the media increased awareness of the busway and served as a frame of reference for constructing expectations and comparing experiences. This analysis has contributed to the wider evaluation of the busway, helping to understand its nature and implementation and informing hypotheses about how the local population interact with the infrastructure by attending to the significance of representations in the media.

  19. Policy Implication of the Awareness and Use of Biotechnology ...

    African Journals Online (AJOL)

    It was observed that genetically modified cassava variety is the most used biotech product in the study area as it scored a mean of 3.25 followed by biotech maize and tree crops which scored means of 2.68 and 2.67 respectively. It was also revealed that genetically modified cassava varieties was the most available biotech ...

  20. Create a translational medicine knowledge repository - Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

    Science.gov (United States)

    2011-01-01

    Pharmaceutical industry consolidation and overall research downsizing threatens the ability of companies to benefit from their previous investments in translational research as key leaders with the most knowledge of the successful use of biomarkers and translational pharmacology models are laid off or accept their severance packages. Two recently published books may help to preserve this type of knowledge but much of this type of information is not in the public domain. Here we propose the creation of a translational medicine knowledge repository where companies can submit their translational research data and access similar data from other companies in a precompetitive environment. This searchable repository would become an invaluable resource for translational scientists and drug developers that could speed and reduce the cost of new drug development. PMID:21569250

  1. Sipuleucel-T (Provenge(®))-Autopsy of an Innovative Paradigm Change in Cancer Treatment: Why a Single-Product Biotech Company Failed to Capitalize on its Breakthrough Invention.

    Science.gov (United States)

    Jarosławski, Szymon; Toumi, Mondher

    2015-10-01

    Approved by the US Food and Drug Administration (FDA) in 2010, sipuleucel-T (Provenge(®)) was the first 'personalized' cancer vaccine for the treatment of prostate cancer in a metastatic, non-symptomatic population of 30,000 men in the USA. Sipuleucel-T is prepared individually for each patient and infused in three sessions over a period of 1 month. However, in 2015, Dendreon, the owner of sipuleucel-T, filed for bankruptcy. This opinion paper reviews the probable reasons this innovative product failed to achieve commercial success. PubMed and internet searches were performed focused on pricing, reimbursement, and market access. We found that sipuleucel-T's FDA approval was delayed by 3 years, reportedly because of the vaccine's new mechanism of action. Sipuleucel-T was cleared by the European Medicines Agency 2 years later, but other national agencies were not approached. It was priced at $US93,000 for a course of treatment, and this high price combined with the company's late securement of reimbursement for the vaccine by the US Centers for Medicare and Medicaid Services (CMS) resulted in another year's delay in accessing the market. Despite a positive recommendation by the National Comprehensive Cancer Network, sipuleucel-T's complex administration, high price, and uncertainty about the reimbursement status deterred doctors from prescribing the product. Furthermore, the vaccine's supply was limited during the first year of launch due to limited manufacturing capacity. In addition, two oral metastatic prostate cancer drugs with similar survival benefits reached the US market 1 and 2 years after sipuleucel-T. Also, even though Dendreon's market capitalization topped $US7.5 billion following the FDA's approval of sipuleucel-T, this value degraded gradually until the firm's bankruptcy 5 years later. We conclude that the bankruptcy of Dendreon was largely due to the delay in securing FDA approval and CMS coverage, as well as the high cost that had to be incurred by providers up-front. Licensing sipuleucel-T to a pharmaceutical company more experienced in the market access pathway may have saved the company and the product.

  2. Create a translational medicine knowledge repository--research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

    Science.gov (United States)

    Littman, Bruce H; Marincola, Francesco M

    2011-05-10

    Pharmaceutical industry consolidation and overall research downsizing threatens the ability of companies to benefit from their previous investments in translational research as key leaders with the most knowledge of the successful use of biomarkers and translational pharmacology models are laid off or accept their severance packages. Two recently published books may help to preserve this type of knowledge but much of this type of information is not in the public domain. Here we propose the creation of a translational medicine knowledge repository where companies can submit their translational research data and access similar data from other companies in a precompetitive environment. This searchable repository would become an invaluable resource for translational scientists and drug developers that could speed and reduce the cost of new drug development.

  3. Create a translational medicine knowledge repository - Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

    Directory of Open Access Journals (Sweden)

    Marincola Francesco M

    2011-05-01

    Full Text Available Abstract Pharmaceutical industry consolidation and overall research downsizing threatens the ability of companies to benefit from their previous investments in translational research as key leaders with the most knowledge of the successful use of biomarkers and translational pharmacology models are laid off or accept their severance packages. Two recently published books may help to preserve this type of knowledge but much of this type of information is not in the public domain. Here we propose the creation of a translational medicine knowledge repository where companies can submit their translational research data and access similar data from other companies in a precompetitive environment. This searchable repository would become an invaluable resource for translational scientists and drug developers that could speed and reduce the cost of new drug development.

  4. (Asian) Life (in Asia) - Book reviews of Margaret Sleeboom-Faulkner (Ed.): Frameworks of Choice, Amsterdam, Amsterdam Press 2010 and Aihwa Ong & Nancy Chen: Asian Biotech, Durham & London, Duke University Press 2010

    DEFF Research Database (Denmark)

    Wahlberg, Ayo

    2011-01-01

    This article is concerned with the idea of societal 'spaciousness' and its relationship to individual and collective autonomy. These issues are analyzed in the context of the eviction of a self-managed social center of left-radical activists in Copenhagen and the protests and public debate...

  5. (Asian) Life (in Asia) - Book reviews of Margaret Sleeboom-Faulkner (Ed.): Frameworks of Choice, Amsterdam, Amsterdam Press 2010 and Aihwa Ong & Nancy Chen: Asian Biotech, Durham & London, Duke University Press 2010

    DEFF Research Database (Denmark)

    Wahlberg, Ayo

    2011-01-01

    This article is concerned with the idea of societal 'spaciousness' and its relationship to individual and collective autonomy. These issues are analyzed in the context of the eviction of a self-managed social center of left-radical activists in Copenhagen and the protests and public debate...... that followed. The authors find that societal spaciousness in Denmark is metaphorically associated with a house or a limited physical space. People should limit themselves in public space, as in a house, to 'make room' for all. Because youngsters are not conceived of as fully fledged political subjects who...

  6. PESC '82; Annual Power Electronics Specialists Conference, 13th, Massachusetts Institute of Technology, Cambridge, MA, June 14-17, 1982, Record

    Science.gov (United States)

    Aspects of power electronics are addressed. The general topics discussed include: inverters and converters, modelling and analysis, motor drives, power conditioning appliances, power semiconductor devices, and power components and protection. Individual subjects considered include: dual-mode forward/flyback converter; a solar cell power supply system using a boost-type bidirectional DC-DC converter; complete DC analysis of the series resonant converter; variable structure control with sliding mode for DC drive speed regulation; a low-cost single-phase induction generator. Also covered are: small-signal modelling of a push-pull current-fed converter; programmable power processor for high-power space applications; high efficiency 3kW switch mode battery charger; comparison of BIMOS device types; power MOSFET temperature measurements; protection of power transistors in electric vehicle drives; general purpose variable frequency inverter using integrated power modules and LSI. For individual items see A84-18377 to A84-18408

  7. [Rets. rmt. : Stefan Halper, Jonathan Clarke. America Alone : The Neo-Conservatives and the Global Order. Cambridge 2004] / Maria Mälksoo

    Index Scriptorium Estoniae

    Mälksoo, Maria, 1979-

    2005-01-01

    Traditsiooniliste konservatiivide S. Halperi ja J. Clarki raamat harutab lahti neokonservatiivse ilmavaate, selle liikumise kujunemise ja mõjuvõimu laienemise ning näitavad, kuidas uuskonservatiivid võtsid võimu USA Riigidepartemangus ja Pentagonis

  8. AA.VV., Musical Networks. Parallel Distributed Perception and Performance, a cura di Niall Griffith e Peter M. Todd, MA: MIT Press, Cambridge, 1999

    Directory of Open Access Journals (Sweden)

    Maurizio Gabrieli

    2013-12-01

    Full Text Available In un periodo in cui le nuove tecnologie stanno trovando una sempre più vasta diffusione nella quasi totalità degli ambiti della produzione e della ricerca musicale, anche il settore dell'analisi musicale sembra essere coinvolto in questo lento ma inesorabile processo. Una delle ricerche più interessanti è quella che ha portato ad utilizzare, per scopi analitici, tecnologie legate alla cosiddetta Intelligenza Artificiale (IA, una disciplina nata verso la fine degli anni Cinquanta con lo scopo di simulare l'intelligenza mediante un sistema computerizzato. In mancanza di una definizione univoca di intelligenza, un primo gruppo di ricercatori del MIT (Massachusetts Institute of Tecnology, diretti da Marvin Minsksy, assunse come paradigma di riferimento l'intelligenza umana e, in una delle ricerche più avanzate nel campo, le cosiddette reti neurali (neural networks.

  9. Neural Networks for Signal Processing 5. Proceedings of the 1995 IEEE Workshop (5th) Held in Cambridge, MA on 31 Aug-2 Sep 95.

    Science.gov (United States)

    1995-01-01

    INFN Sezione Sanith Viale Regina Elena 299, 00161 Roma, Italy Nestor Parga Departamento de Ffsica Te6rica, Universidad Aut6noma de Madrid Ciudad ... Universitaria de Cantoblanco, 28049 Madrid , Spain Jean-Pierre Nadal Laboratoire de Physique Statistique, Ecole Normale- Sup4rieure 24, rue Lhomond, 75231...what effect on the de - gree of approximation; in particular, to gain an insight on how to choose an activation function, rather than to obtain the best

  10. A Review: R. Baldwin, “The Great Convergence: Information Technology and the New Globalization” (Cambridge: Belknap Press of Harvard University Press, 2016

    Directory of Open Access Journals (Sweden)

    Nicola Montagna

    2017-05-01

    Full Text Available In the introduction of his book, Richard Baldwin ambitiously says that its reading will “change our way to look at globalisation”. While the aim may sound too pretentious and in some respect misplaced, The Great Convergence: Information Technology and the New Globalization is certainly timely. While it is hard to say whether or not globalisation has entered a terminal crisis, it is true that we are witnessing to processes of de-globalisation and relative attempts of national governments to regain some sovreignty. Against the view that globalisation has reached its terminus, this book states that on the contary it is entering a new phase. Its central assertion is that the radical changes in communication technology around 1990s have transformed the nature of globalization, reducing the costs of production and transferring massive north-to-south flows of know-how. What Baldwin calls “New Globalisation” not only has produced a great convergence of profit shares between the most industrialized and some industrializing countries as a consequence of shifting production to the latter, but it also set the basis for a “Third Wave” of globalisation.

  11. Rediscovering Antiquity: Karl Weber and the Excavation of Herculaneum, Pompeii, and Stabiae, by C.C. Parslow. Cambridge University Press, 1995

    Directory of Open Access Journals (Sweden)

    James E. Snead

    1997-11-01

    Full Text Available Rediscovering Antiquity is an example of the genre of historical writing which seeks to recast the careers of little-known figures who have fallen into obscurity. This is typically intended to move them and their work into the proper "lineage," that is, the select group of ancestral figures from which modern practices are derived. Parslow is interested in the 18th century excavations of the Vesuvian cities, which, he argues, have been misunderstood by historians of archaeology. Indeed, common sources, such as Daniel (1981:55, describe the initial explorations of Pompeii, Herculaneum, and Stabiae, sponsored by the Bourbon kings of Naples as "...treasure hunts and not serious excavations." While the Roman artifacts removed from the sites are credited with spurring interest in antiquity in Enlightenment Europe, modern scholars have until now devoted little attention to the means through which they were recovered.

  12. International Laser Radar Conference (16th) held at the Massachusetts Institute of Technology, Cambridge, Massachusetts on 20-24 July 1992. Part 1

    Science.gov (United States)

    1993-07-24

    Aspendale, Victoria North York Ontario AUSTRALIA M3J 1P3 CANADA Professor Giorgio Fiocco Dr. Wolfgang Renger Dipto di Fisica DLR Institut fir Physik...der Citta Universitaria Atmosphare Pizzale Aldo Moro #2 D-8031 Oberplaffenhofen 00185-Roma GERMANY ITALY Dr. Pierre H. Flamant Dr. Leopoldo Stefanutti...Adriani, Gian Paolo Gobbi and Sante Centurioni Istituto Fisica dell’Atmosfera, CNR, C.P. 27, Frascati, Italy The Pinatubo eruptions of June 1991

  13. Educational Implications of Psychopathology for Brain-Injured Children; Lesley College Annual Graduate Symposium (3rd, Cambridge, Massachusetts, May 13, 1967).

    Science.gov (United States)

    Gertz, Boris, Ed.

    The symposium report includes the text of an illustrated lecture given by William M. Cruickshank on "Psychopathology and Implications for Educating Brain-Injured Children." Considered in the lecture are hyperactivity, the needs of hyperative children, and educational setting and curriculum. Panel reactions are provided by E.F. Rabe, a pediatric…

  14. Peptides. Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991.

    Science.gov (United States)

    1992-01-01

    G. Savianob, P.A. Temussib, S. Salvadoric and R. Tomatisc ’ICMIB del CNR. via Toiano 6. Arco Felice. Napoli. Italv bDipartimento di Chimica...peptides, the a-factor (WHWLQLKPGQPMY) and the a-factor, which are secreted by MATa and MATa cells, respectively. Whereas the a- factor is a simple...Activities were measured using a halo growth arrest assay with strain RC757 ( MATa sst2-1) as the test organism. use of Fmoc and OFm protecting groups

  15. Proceedings of the Aircraft Wake Vortices Conference, March 15-17, 1977, held at the Transportation Systems Center, Kendall Square, Cambridge, MA

    Science.gov (United States)

    1977-06-01

    Adrs 1,Wr Ui o U.5 Su epeenartmn N oternprttosA75180 ~~~/l tteTransportation Systems Cne 1 otato CneKendall Square, Cabide MA1 12.Spo sor volumen ...establish a great demand percent. That gives you some sort of a feel for airport facilities to accommodate the traf- for the magnitude of the problem as it...recording (if available) is consulted to estab- r lish the precise nature and magnitude of the B747-proup I Over 170.000 Over 375.000 upset. In general, the

  16. Book review of Capital in the Twenty-First Century, by Thomas Piketty. Cambridge, Massachusetts, London, England: The Belknap Press of Harvard Press, 2014, 605 pages

    Directory of Open Access Journals (Sweden)

    Paul Dobrescu

    2015-04-01

    Full Text Available “Every now and then, the field of economics produces an important book; this is one of them” (Cowen, 2014. These are the opening words of Tyler Cowen’s presentation of Thomas Piketty’s work, “Capital in the Twenty-First Century” (Piketty, 2014, in Foreign Affairs. This is a book that is visibly placed in all important bookstores around the world, widely debated, acclaimed, sold (over 1 million copies have been sold so far. It has been favorably reviewed or quoted in all major journals. The assessment of “Capital in the Twenty-First Century” by Paul Krugman, Nobel Economics Prize Laureate as a “magnificent, sweeping meditation on inequality”, is highly relevant: “This is a book that will change both the way we think about society and the way we do economics” (Krugman, 2014. Finally, Piketty’s book is included in the list of the year’s best books by prestigious journals, such as The Economist, Financial Times, The Washington Post, Observer, The Independent, Daily Telegraph; Financial Times and McKinsey have hailed it as the best book of 2014.

  17. OSA Proceedings of the Topical Meeting on Nonlinear Guided-Wave Phenomena Held in Cambridge, England (United Kingdom) on 2-4 September 1991. Volume 15

    Science.gov (United States)

    1992-05-22

    B 43(2), 1719 (1991). 6. L. Banyai and S. W. Koch, Z. Phys. B63, 283 (1986). 7. J. V. Moloney, M. R. Belic , and H. M. Gibbs, Opt. Commun. 41, 379... belical spatial grating of second-order susceptibility with spatial period (Ak)-1 is formed in the defects system. In the other case (ii) the

  18. International Conference on Deformation, Yield and Fracture of Polymers (9th) Held in Cambridge, UK on 11-14 April, 1994. Conference Papers

    Science.gov (United States)

    1994-01-01

    Benavente, JM Perena, • Pdrez and A Bello (Instituto de Ciencia y Tecnologia de Polimeros , Madrid, Spain) P71 Deformation of pressure annealed...and the drawing temperature. *instituto de Ciencia y Tecnologfa de Polimeros , Juan de la Cierva 3. 28006-Madrid, Spain. Po𔃺 I EXPERIMENTAL The

  19. National Association for Research in Science Teaching (NARST). Annual Meeting (65th, Cambridge, Massachusetts, March 21-25, 1992). Abstracts of Presented Papers.

    Science.gov (United States)

    Govindarajan, Girish, Ed.

    This product of an annual meeting presents abstracts of symposia, contributed papers, paper sets, discussion groups, reports, poster sessions, and panel presentations. Topics include: science teaching, gender differences, science education reform, constructivism, biological concepts, concept mapping, attitude/behavior change, conceptual…

  20. Reseña. A History of the Global Economy: 1500 to the Present. Joerg Baten (ed.. Cambridge University Press, 2016, 369 p.

    Directory of Open Access Journals (Sweden)

    Giusseppe De Corso

    2016-08-01

    Full Text Available El texto en cuestión es un intento, no muy exitoso según nuestra opinión, de hacer un recorrido a lo largo de la Historia Económica Mundial desde 1500 hasta el presente. Se presenta un conjunto de ensayos breves, unos más especializados que otros, pero bastante disparejos en los argumentos que se tocan, las regiones geográficas y el tiempo. La línea de tiempo analizada es incoherente con la narración, y brinca entre épocas, regiones y temas sin mucha lógica secuencial y ningún intento de entrelazar los argumentos. Es decir, la primera impresión que se tiene de la lectura es una fragmentación de la temática en trozos desconectados. El capítulo conclusivo no ayuda en nada a hilvanar el texto.

  1. Fundamentals of Tribology; Proceedings of the International Conference on the Fundamentals of Tribology held at The Massachusetts Institute of Technology, Cambridge, MA

    Science.gov (United States)

    1978-06-01

    wheel dressinq, the dse of coarser dressing leads results in the improvement of the bearing area of ground surfaces. Although, this fact may be used...Structure of the tribo-system IV. Tribological characteristics Based on these four groups of parameters, a checklist has been designed which can be used

  2. The Cambridge Mindreading Face-Voice Battery for Children (CAM-C): complex emotion recognition in children with and without autism spectrum conditions

    OpenAIRE

    Golan, Ofer; Sinai-Gavrilov, Yana; Baron-Cohen, Simon

    2015-01-01

    Background Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six ?basic? emotions, usually using still pictures of faces. Methods This study describes a new battery of tasks for testing recognition of nine complex emotions and mental states from video clips of faces and from voice recordings taken from the Mindreading DVD. This battery (the ...

  3. Sustainable Materials Management (SMM) Web Academy Webinar: Cupertino CA and Cambridge MA: Tips for How Communities Can Successfully Engage Businesses to Divert Food Scraps

    Science.gov (United States)

    This is a webinar page for the Sustainable Management of Materials (SMM) Web Academy webinar titled Let’s WRAP (Wrap Recycling Action Program): Best Practices to Boost Plastic Film Recycling in Your Community

  4. Seventh Annual Congress of the European Undersea Biomedical Society and Symposium on Decompression Sickness Held at Cambridge, England on July 21-24 1981,

    Science.gov (United States)

    1981-09-09

    rapidly by diuresis as can saline or Ringers solution). 1i C-10-81 Steroids are useful in opposing permeability increases, augmenting catechol...responses, inhibiting leukocyte "stickiness", and stabilizing lyso- somal membranes. Glucocorticoids should be used in preference to salt- retaining steroids

  5. Computer Graphics Special Issue on 1992 Symposium on Interactive 3D graphics Held in Cambridge, Massachusetts on 29 March-1 April 1992

    Science.gov (United States)

    1992-01-01

    publication. Thanks are due to Barry Vercoc and Mike Hawley for their rielp with CSOUND. banks! Special mention to Ali Azarbayejani, our newest member...kernel coefficients are computed from the scaling and By limiting the kemel radius to two inter-voxel distances, every rotation portions of the view

  6. The Psychology of Second Language Learning: Papers from the Second International Congress of Applied Linguistics, Cambridge, 8-12 September 1969.

    Science.gov (United States)

    Pimsleur, Paul, Ed.; Quinn, Terence, Ed.

    The 19 papers in this collection cover diversified topics in the general area of psychology and second language learning. No single method of language teaching emerges, but the complexity of second language behavior and the importance of psychology in the field are underlined. Several trends seem to be most prevalent. There is a new focus on the…

  7. Human Immunodeficiency Virus Seroprevalence among Inmates of the Penitentiary Complex of the Region of Campinas, State of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Neusa Maria Osti

    1999-07-01

    Full Text Available Six hundred and ninety three male inmates from three penitentiaries, two (A and B maximum-security systems and one (C minimum-security facility, located in Campinas, State of São Paulo, Brazil were studied for the presence of human immunodeficiency virus (HIV antibodies, using a cross-sectional design. The search for anti-HIV antibodies in 693 samples of sera collected was carried out by two serological tests: (a the Microparticle enzyme immunoassay-HIV-1 and HIV-2 (MEIA (Abbott Laboratories and (b the Western Blot-HIV-1 (WB (Cambridge Biotech Corporation to confirm positive results with MEIA. Sera reactivity for HIV antibodies was 14.4%. The highest frequency of anti-HIV antibodies was found in the A and B maximum-security prisons: 17% and 21.5%, respectively. In prison C, the frequency of reagents was 10.9%. Seventy three inmates, initially negative in the MEIA test, were checked again five and seven months later. Three of them, all from the maximum-security facilities, became reactive in the MEIA test, with confirmation in the WB, suggesting that serological conversion had occurred after imprisonment.

  8. James M. BROPHY, Popular Culture and the Public Sphere in the Rhineland 1800-1850, Cambridge, Cambridge University Press, 2009, 365 p. ISBN: 978 0 521 12392 1. 60 livres sterling.

    OpenAIRE

    König, Mareike

    2011-01-01

    Le 28 mai 1832, au lendemain de la fête de Hambach, des habitants du petit village de Saint-Wendel, dans le minuscule duché de Lichtenberg, plantaient un « arbre de la liberté » au centre-ville. Ils voulaient ainsi exprimer leur solidarité avec les idées libérales-nationales énoncées la veille. À côté de l’arbre, un panneau mettait en garde : « Mort à ceux qui touchent à cet arbre ». Les tentatives d’intervention du maire et de deux gendarmes échouèrent devant la résistance violente des habit...

  9. Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo.

    Science.gov (United States)

    Niama, Roch Fabien; Loukabou Bongolo, Nadia Claricelle; Bayonne Kombo, Edith Sophie; Yengo, Ruth; Mayengue, Pembe Issamou; Mandingha Kosso, Etoka-Beka; Louzolo, Igor; Macosso, Lucette; Dzeret, Ghislain; Dzabatou Babeaux, Angélie Serge Patrick; Puruehnce, Marie-Francke; Parra, Henri Joseph

    2017-01-01

    HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled. To detect HIV antibodies, two consecutive ELISA assays were used (Genscreen Ultra HIV Ag/Ac, (BioRad, France) and Enzygnostic Intergral II (Siemens, GMBH, Marbug-Germany). In case of discordant results, the Western blot test II, HIV1 and 2 (Bio-Rad, Marne la Coquette, France) was used as the reference method. The RPR (Bio-Scan, Karnataka, India) test was performed to detect syphilis infection. The RPR positive results were confirmed using the TPHA test (Biotech, Cambridge, UK). Data were analyzed using SPSS 17.0 software. A total of 2979 pregnant women attending ANCs were enrolled. The global HIV infection rate was estimated to be 3.6% (CI: 95%; 3.0-4.4). As expected, HIV prevalence was significantly higher in women aged above 25 years (4.4% (3.4-5.6), p = 0.026) and those attending urban ANCs (5.04%, p syphilis occurrence was significantly higher among the single women compared to the married ones (4.4% VS 2.7%; p syphilis coinfection occurred in 22 cases (0.73%). The prevalence's of syphilis and HIV were relatively low. Marital status and sentinel site location were a risk factor associated with HIV and syphilis infections respectively. Therefore, substantial effort is needed to reinforce prevention strategies in this population to prevent mother-to-child and further horizontal transmissions of these infections.

  10. Valuation in life sciences: a practical guide

    National Research Council Canada - National Science Library

    Bogdan, Boris; Villiger, Ralph

    2010-01-01

    ... apply valuation methodologies in life sciences. One of the complicating factors is that, compared to other industries, valuation of biotech innovation is much more demanding. The long 10-15-year development and clinical trials process still represents the main risks faced by any biotech company. Added to that is the fact that getting a drug across the regulato...

  11. Learning Outcomes Associated with Classroom Implementation of a Biotechnology-Themed Video Game

    Science.gov (United States)

    Barko, Tim; Sadler, Troy D.

    2013-01-01

    The educational video game Mission Biotech provides a virtual experience for students in learning biotechnology materials and tools. This study explores the use of Mission Biotech and the associated curriculum by three high school teachers and their students. All three classes demonstrated gains on a curriculum-aligned test of science content.…

  12. Valuation in life sciences: a practical guide

    National Research Council Canada - National Science Library

    Bogdan, Boris; Villiger, Ralph

    2010-01-01

    ... valuation methodologies in life sciences. One of the complicating factors is that, compared to other industries, valuation of biotech innovation is much more demanding. The long 10-15-year development and clinical trials process still represents the main risks faced by any biotech company. Added to that is the fact that getting a drug across the regulato...

  13. Innovative Tools for Scientific and Technological Education in Italian Secondary Schools

    Science.gov (United States)

    Santucci, Annalisa; Mini, Roberta; Ferro, Elisa; Martelli, Paola; Trabalzini, Lorenza

    2004-01-01

    This paper describes the project "Biotech a Scuola" ("Biotech at School"), financed by the Italian Ministry of Education within the SeT program (Special Project for Scientific-Technological Education). The project involved the University of Siena, five senior and junior secondary schools in the Siena area, and a private…

  14. Molecular diversity in persimmon (Diospyros kaki L.) cultivars ...

    African Journals Online (AJOL)

    SERVER

    2007-10-18

    Oct 18, 2007 ... REFERENCES. Aras S (2003). Molecular discrimination of some Dogrose (Rosa sp.) growing around Tokat region in Turkey by RAPD markers. Biotech. Biotech. Eq. 17: 27-34. Aras S, Polat JB, Cansaran D, Söylemezoğlu G (2005). Genetic. Identification of Büzgülü Grape Cultivars (Vitis vinifera L.) grown ...

  15. Immobilized Enzymes/Bacteria for Naval Applications - Initial Data Base.

    Science.gov (United States)

    1981-05-31

    strains of Bacillus sphaericus are toxic to several species of mosquito larva. These bacilli have long-term activity. Immobilization of the micro...electrode for phenol. Biotech. Bioeng. , 21, 671-678. 19. Singer, S. (1980) Bacillus sphaericus for the control of mosquitoes, Biotech. Bioen.&., 22, 1335

  16. Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging

    National Research Council Canada - National Science Library

    Greatorex, Jane S; Palmer, Elizabeth A; Pomerantz, Roger J; Dangerfield, John A; Lever, Andrew M. L

    2006-01-01

    1 Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK 2 Center for Human Virology, Division of Infectious Diseases, Thomas Jefferson University, Philadelphia...

  17. John Considine: Dictionaries in Early Modern Europe: Lexicography ...

    African Journals Online (AJOL)

    Abstract. John Considine. Dictionaries in Early Modern Europe: Lexicography and the Making of Heritage. 2008, xiv + 393 pp. ISBN: 9780521886741. Cambridge: Cambridge University Press. Price: £55 / $99.

  18. James L.W. West III, ed. The Cambridge Edition of the Works of F. Scott Fitzgerald : « Trimalchio » : an Early Version of The Great Gatsby.

    Directory of Open Access Journals (Sweden)

    Jean-Loup Bourget

    2006-04-01

    Full Text Available Présenté comme « an early version of The Great Gatsby », “Trimalchio” est une tentative de reconstitution du manuscrit dactylographié envoyé par Fitzgerald à son éditeur, Scribner’s, en octobre 1924. Ce tapuscrit étant perdu, le texte a été établi à partir des épreuves avant correction, elles-mêmes composées à partir du tapuscrit. Il représente donc un stade intermédiaire entre le manuscrit holographe conservé à Princeton (fac-similé publié par les soins de Matthew J. Bruccoli en 1973 et le ...

  19. Proceedings of the International Conference on the Performance of Off-Road Vehicles and Machines (8th). Volume 3. Held at Cambridge England, on August 5-11, 1984.

    Science.gov (United States)

    1984-08-01

    non fossil- based fuel from comodities s sugar, sunflower seed and cassava . Other countries however hav .rlnotIvely little opportunity for the economic...consumption tillage operations was used to show how, by com- puter models, the influence of different technical and agri- cultural parameters on field capacity...leveled, and a layer of damp tissue paper was carefully laid on the soil laye. The step was repeated until 10-12 layers of tissue paper were preset In

  20. Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial 1 2 3 4

    OpenAIRE

    Jebb, Susan A.; Lovegrove, Julie A.; Griffin, Bruce A.; Frost, Gary S; Moore, Carmel S.; Chatfield, Mark D.; Bluck, Les J.; Williams, Christine M.; Sanders, Thomas AB

    2010-01-01

    Background: Insulin sensitivity (Si) is improved by weight loss and exercise, but the effects of the replacement of saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) or carbohydrates of high glycemic index (HGI) or low glycemic index (LGI) are uncertain. Objective: We conducted a dietary intervention trial to study these effects in participants at risk of developing metabolic syndrome. Design: We conducted a 5-center, parallel design, randomized controlled trial [RISCK (Re...

  1. La autoridad de las administraciones internacionales en la sociedad internacional en "The Authority of International Administrations in International Society", Review of International Studies, Vol.32/3., Cambridge Journals, Reino Unido, 2006.

    OpenAIRE

    Dominik ZAUM

    2009-01-01

    En este artículo se analiza cómo las administraciones internacionales que ejercen un poder gubernamental en territorios post conflicto justifican su autoridad política sin tener legitimidad democrática. En el artículo se estudia el establecimiento, los mandatos y las prácticas de gobierno de las administraciones de Bosnia, Kosovo y Timor Oriental y se identifican cinco fundamentos de la autoridad: el consentimiento, la delegación, el mantenimiento de la paz y la seguridad, el fomento de los d...

  2. Proceedings of the International Conference on The Performance of Off-Road Vehicles and Machines (8th). Volume 2. Held at Cambridge England, on August 5-11, 1984.

    Science.gov (United States)

    1984-08-01

    Werte gelten fur 10U Z 2 und 30 Schrlglauf. Wiese. Stoppel - und Maisfeld bringen die grdl~eren Widerstandserhdhun- gen gegenuber dem glatten Relfen, der...tyre and drift angle at different and curves of figure 13. load from figure 12. .’ L! i ’+ ’ J II.I1l p • : .- a., .. " + + :-"" I 667 1.0 stoppel ...of rolling resistanoce coefficient of profiled r tyres coared with ribless ty"r. Ar- Beg 1.0 Stoppel Stubble 1 0.5 Z;_ __ 031 Sdfg~ufwnks" Ordt AnEe

  3. Proceedings of the MIT/ONR (Massachusetts Institute of Technology/Office of Naval Research) Workshop on C3 (Command, Control, and Communications) Systems (6th) Held at Cambridge, Massachusetts on 25-29 July 1983

    Science.gov (United States)

    1983-12-01

    provided to allow the analyst to organizacions . These same collection tasking selectively browse through a large text or imagay requests will also be...4.3. Theorem IV Giver, an index set XD)I, containing r elementos with the _following property: 263 S. LINEARIZATION mrain i ~j~djk.Tk + min ),jldjk

  4. Proceedings of the International Conference on The Performance of Off-Road Vehicles and Machines (8th). Volume 1. Held at Cambridge England, on August 5-11, 1984.

    Science.gov (United States)

    1984-08-01

    8217 useful correlotion betwcen vehicle jdramcters and suil p irdatihters in tia frictional s .ils the I resent study Af erformance |prediction of neumatic ...is the time-stress (t-o) relation or curve on the oscillograph shows particular shapes as if it were random vibration. These curves are classified ...variations in Fig.lO are roughly classified into four types as follows by connecting small peaks of stress variations. Type(I) Trapezoid type (Fig.lOa

  5. Mary Gluck, Popular Bohemia. Modernism and Urban Culture in Nineteenth-Century Paris, Cambridge/London, Harvard University Press, 2005, 224 p. ISBN : 0-674-01530-4. 24, 95 livres sterling.

    OpenAIRE

    Lenoble., Benoît

    2008-01-01

    Le titre est relativement trompeur. Près de dix-neuf ans après la parution de l’ouvrage de Jerrold Seigel sur la culture de la bohème dans le Paris du xixe siècle, on pourrait penser que Mary Gluck, professeur d’histoire et de la littérature comparée à la Brown University, propose une relecture du même objet . Il s’agit en fait d’une histoire culturelle du modernisme à travers les générations et les courants de la bohème parisienne, des années 1830 à la veille de la Première guerre mondiale. ...

  6. 從WTO生技產品案爭端解決小組報告看GMO國際貿易中國際貿易法與國際環境法之衝突與解決可能 Conflicts and Resolutions of International Trade Law and International Law of Environment in International Trade of GMOs: A Perspective of WTO Biotech Products Case

    National Research Council Canada - National Science Library

    許耀明 Yao-Ming Hsu

    2007-01-01

    ... 生技產品案報告為例,討論WTO 爭端解決機制中適用其他國際法規範之可能性以為說明。 From general theories of international trade law and international law of environment, this article focuses...

  7. Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy

    DEFF Research Database (Denmark)

    Strange, Michael Stewart

    2009-01-01

    Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy (Cambridge: Cambridge University Press), 254pp. Udgivelsesdato: 2009......Book Review: John M. Hobson and Leonard Seabrooke (2007) (eds) Everyday Politics of the World Economy (Cambridge: Cambridge University Press), 254pp. Udgivelsesdato: 2009...

  8. Big Data, Small Media

    Directory of Open Access Journals (Sweden)

    Grant Bollmer

    2014-08-01

    Andrew Dubber Radio in the Digital Age Polity, Cambridge, 2013   Charles Ess Digital Media Ethics, Second Edition Polity, Cambridge, 2014   Graeme Kirkpatrick Computer Games and the Social Imaginary Polity, Cambridge, 2013   Dhiraj Murthy Twitter: Social Communication in the Twitter Age Polity, Cambrige, 2013   Jill Walker Rettberg Blogging, Second Edition Polity, Cambridge, 2014

  9. Coexistence, North American style: regulation and litigation.

    Science.gov (United States)

    Redick, Thomas

    2012-01-01

    Globally, biotech crops have left a legacy of success and some notable failures due to regulatory and litigious barriers to entry, with a pipeline of potentially beneficial biotech agricultural products lined up and awaiting approval. Compared with traditional agriculture, these crops provide significant health benefits to environmental and human health benefits, including organic systems. While the rest of the world has increased acreage of biotech crops at a steady annual rate of 10%, North America-the birthplace of most biotech crops-has reached a critical turning point in its regulatory evolution. Biotech crops can play a major role in creating a more sustainable agricultural landscape, which is increasingly well-documented, but future commercial use may be hampered by regulation and litigation that place organic and non-GMO agriculture on a pedestal, which could force many biotech crops into containment. If producers of biotech crops are required to prevent their crops from contaminating these other, high premium specialty crops through migration, innovation in agricultural biotechnology will suffer (as the European experience with agricultural biotechnology clearly demonstrates).

  10. Gene cuisine or Frankenfood? The theory of reasoned action as an audience segmentation strategy for messages about genetically modified foods.

    Science.gov (United States)

    Silk, Kami J; Weiner, Judith; Parrott, Roxanne L

    2005-12-01

    Genetically modified (GM) foods are currently a controversial topic about which the lay public in the United States knows little. Formative research has demonstrated that the lay public is uncertain and concerned about GM foods. This study (N = 858) extends focus group research by using the Theory of Reasoned Action (TRA) to examine attitudes and subjective norms related to GM foods as a theoretical strategy for audience segmentation. A hierarchical cluster analysis revealed four unique audiences based on their attitude and subjective norm toward GM foods (ambivalent-biotech, antibiotech, biotech-normer, and biotech individual). Results are discussed in terms of the theoretical and practical significance for audience segmentation.

  11. Estonian science breeds world-class researches / ToivoTänavsuu, Hille Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2010-01-01

    Eesti teadusfirmadest: biotehnoloogia ettevõtted Celecure AS, Protobios OÜ, Icosagen AS, Asper Biotech AS ja Solis BioDyne OÜ, geenitehnoloogia firma Genorama OÜ, keemiatehnoloogia ettevõte AS Cambrex Tallinn

  12. Universities as Embedded Knowledge Hubs and the Challenge of Local Development the Us Lessons and the Italian Case

    National Research Council Canada - National Science Library

    Ciapetti, Lorenzo

    2009-01-01

    ...; section three examines the lessons we can extract from the US university system (with a particular regard to the case of Johns Hopkins University and the recent project for a biotech park in the city of Baltimore...

  13. Experiment list: SRX032893 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology || antibody catalog number=sc-7196X http://dbarch... Adipocyte Culture || strain=3T3-L1 || cell type=Cultured Adipocytes || chip antibody=PPARgamma || antibody vendor=Santa Cruz Biotech

  14. Experiment list: SRX029315 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/e...| cell type=CD34+CD133+ hematopoietic progenitor cells (HPCs) || antibody=anti-GABP-alpha || antibody manufacturer=Santa Cruz Biotech

  15. Experiment list: SRX543048 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available nology http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/ea...CID.adh murine thymic lymphoma || development stage=DN3 || chip antibody=rabbit anti-Miz-1 || chip antibody vendor=Santa Cruz Biotech

  16. Human T-cell Lymphotropic Virus in a Population of Pregnant ...

    African Journals Online (AJOL)

    FOMCS2

    Human T-cell lymphotropic virus in a population of pregnant women and commercial ... Forbi JC,. Virology laboratory,. Innovative Biotech-Keffi, PO Box 30 Keffi,. 1. Abdu Abubakar Street ... neurological syndromes 6. Over 20 million persons ...

  17. MA Common Tern Census

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The official State census period for common terns was June 1-10. The survey was conducted on June 4 by Biologist Healey, Biotech Springfield, and Maintenance...

  18. In vivo activities of Baicalin against Chlamydia trachomatis

    African Journals Online (AJOL)

    USER

    2010-03-15

    Rasmussen et al., 1997). The infectivity of the chlamydia was expressed as the number of inclusion forming units. Baicalin (HPLC Content > 98.0%) from Chongqing Green Valley. Bio-tech Co. LTD. (Chongqing, China).

  19. final thecnical report promoting innovation in the services sector

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ben Petrazzini

    2014-01-15

    -TIC, outsourcing, mining, logistics, retail, creative services, sport services, and biotech services). Even if case studies cannot be representative of an economy as a whole, the main mechanisms of innovation and successful ...

  20. Small company mergers--good for whom?

    Science.gov (United States)

    Maybeck, Vanessa; Bains, William

    2006-11-01

    An analysis of 105 mergers among small UK biotech companies over a 10-year period shows that the improvement of shareholder positions, rather than product pipelines or business opportunities, is the main motivation for such transactions.

  1. science where culture matters: a neo-classical approach to explore ...

    Indian Academy of Sciences (India)

    SCIENCE WHERE CULTURE MATTERS: A NEO-CLASSICAL APPROACH TO EXPLORE UNTAPPED BACTERIAL DIVERSITY. MILIND WATVE; Dept of Microbiology, Abasaheb Garware College, Pune. www.culturematters.org; * Life Research Foundation, Pune; * Evolvus Biotech Pvt. Ltd.,Pune ...

  2. Eestis levinud HIVi erilisus jätab nakatunud vaktsiinilootuseta / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2002-01-01

    Soome biotehnoloogiafirma FIT Biotech on loobumas kavast katsetada Eesti teadlaste leiutatud vaktsiini ka siinsete HIV-positiivsete katserühmal, sest Eestis on levinud maailmas üliharuldane HI-viiruse G-alatüüp

  3. Keeping enzymes kosher

    DEFF Research Database (Denmark)

    Fischer, Johan

    2015-01-01

    Biotech companies increasingly seek certification for compliance with religious and dietary requirements in order to address new consumer markets. Technology plays a crucial role in such inspections alongside centuries old traditions and practices...

  4. Eesti teadlaste HIV-vaktsiini süstitakse katseks aafriklastele / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 5. apr., lk. 2. Tartu teadlaste leiutatud ning Soome biotehnoloogiafirma FIT Biotech arendatavat vaktsiini katsetatakse Lõuna-Aafrika Vabariigis 60 surmaviirusega nakatunud inimese peal. Lisa: Eestlaste HIV-vaktsiini senine lugu

  5. 77 FR 26304 - Prospective Grant of Exclusive License: Development of Ocular Therapeutics Utilizing the Peptide...

    Science.gov (United States)

    2012-05-03

    ... Human Services, is contemplating the grant of an exclusive patent license to ODIN Biotech, a Texas.... Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology...

  6. 77 FR 26772 - Prospective Grant of Exclusive License: Ocular Therapeutics Agent Delivery Devices and Methods...

    Science.gov (United States)

    2012-05-07

    ..., and NIBIB) (E-241-1999/0), to ODIN Biotech having a place of business in 4000 Hanover Street, Dallas.... Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology...

  7. Notes on Commercialization of Biotechnology Research

    DEFF Research Database (Denmark)

    Høy Jakobsen, Palle

    This book introduces aspects of commercialization of biomedical & biotech research including pharmaceutical drug and medical device development, innovation concepts, patent protection & commercialisation of research by securing investments in new companies and by licensing of the commersialisatio...

  8. Revving up the immune therapy business.

    Science.gov (United States)

    2015-08-01

    Giant pharmaceutical companies and biotech startups are seizing opportunities to advance their oncologic immunotherapy business and provide patients with more-effective treatment options. ©2015 American Association for Cancer Research.

  9. Experiment list: SRX150448 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available antibody vendorname=Santa Cruz Biotech || antibody vendorid=sc-1703 || control=UCDavis || control description=Input library was prepa...red at UC Davis. || control=UCDavis || control description=Input library was prepare

  10. 6th Annual European Antibody Congress 2010: November 29-December 1, 2010, Geneva, Switzerland.

    Science.gov (United States)

    Beck, Alain; Wurch, Thierry; Reichert, Janice M

    2011-01-01

    The 6th European Antibody Congress (EAC), organized by Terrapinn Ltd., was held in Geneva, Switzerland, which was also the location of the 4th and 5th EAC. As was the case in 2008 and 2009, the EAC was again the largest antibody congress held in Europe, drawing nearly 250 delegates in 2010. Numerous pharmaceutical and biopharmaceutical companies active in the field of therapeutic antibody development were represented, as were start-up and academic organizations and representatives from the US Food and Drug Administration FDA. The global trends in antibody research and development were discussed, including success stories of recent marketing authorizations of golimumab (Simponi®) and canakinumab (Ilaris®) by Johnson & Johnson and Novartis, respectively, updates on antibodies in late clinical development (obinutuzumab/GA101, farletuzumab/MORAb-003 and itolizumab/T1 h, by Glycart/Roche, Morphotek and Biocon, respectively) and success rates for this fast-expanding class of therapeutics (Tufts Center for the Study of Drug Development). Case studies covering clinical progress of girentuximab (Wilex), evaluation of panobacumab (Kenta Biotech), characterization of therapeutic antibody candidates by protein microarrays (Protagen), antibody-drug conjugates (sanofi-aventis, ImmunoGen, Seattle Genetics, Wyeth/Pfizer), radio-immunoconjugates (Bayer Schering Pharma, Université de Nantes) and new scaffolds (Ablynx, AdAlta, Domantis/GlaxoSmithKline, Fresenius, Molecular Partners, Pieris, Scil Proteins, Pfizer, University of Zurich) were presented. Major antibody structural improvements were showcased, including the latest selection engineering of the best isotypes (Abbott, Pfizer, Pierre Fabre), hinge domain (Pierre Fabre), dual antibodies (Abbott), IgG-like bispecific antibodies (Biogen Idec), antibody epitope mapping case studies (Eli Lilly), insights in FcγRII receptor (University of Cambridge), as well as novel tools for antibody fragmentation (Genovis). Improvements of

  11. Nanotechnology: Threats and Deterrent Opportunities by 2035

    Science.gov (United States)

    2010-02-17

    January 2010. 52 Hall, Nanofuture, 34. 53 Richard W. Oliver, The Biotech Age: The Business of Biotech and How to Profit From It, (New York: McGraw...Garner, and Richard Thompson, “Human Terrain Mapping: A Critical First Step to Winning the COIN Fight,” Military Review, March-April 2008, 19-20. 81...Accessed 16 February 2010. 105 Feyman, discussion, http://www.its.caltech.edu/~ feynman /, accessed 31 January 2010.

  12. Editorial: Latest methods and advances in biotechnology.

    Science.gov (United States)

    Lee, Sang Yup; Jungbauer, Alois

    2014-01-01

    The latest "Biotech Methods and Advances" special issue of Biotechnology Journal continues the BTJ tradition of featuring the latest breakthroughs in biotechnology. The special issue is edited by our Editors-in-Chief, Prof. Sang Yup Lee and Prof. Alois Jungbauer and covers a wide array of topics in biotechnology, including the perennial favorite workhorses of the biotech industry, Chinese hamster ovary (CHO) cell and Escherichia coli. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Disease Heterogeneity and Immune Biomarkers in Preclinical Mouse Models of Ovarian Carcinogenesis

    Science.gov (United States)

    2014-08-01

    mice developed ovarian tumors, very low tumor burden was identified at necropsy . Furthermore, significant T cell infiltration was observed in tumors... necropsy . Harvested tissue was fixed in 10% buffered formalin (Fisher Scientific, Kalamazoo, MI) for 24 hours, stored in 70% ethanol for 3 days and...Assay Biotech, Sunnyvale, CA), and desmin (sc7559, 1:50, Santa Cruz Biotech- nology, Dallas, TX). Secondary antibodies used include anti- rabbit -HRP

  14. A CADD-alog of strategies in pharma

    Science.gov (United States)

    Warr, Wendy A.

    2017-03-01

    A special issue on computer-aided drug design (CADD) strategies in pharma discusses how CADD groups in different environments work. Perspectives were collected from authors in 11 organizations: four big pharmaceutical companies, one major biotechnology company, one smaller biotech, one private pharmaceutical company, two contract research organizations (CROs), one university, and one that spans the breadth of big pharmaceutical companies and one smaller biotech.

  15. Risk mitigation strategies for viral contamination of biotechnology products: consideration of best practices.

    Science.gov (United States)

    Rosenberg, Amy S; Cherney, Barry; Brorson, Kurt; Clouse, Kathleen; Kozlowski, Steven; Hughes, Patricia; Friedman, Rick

    2011-01-01

    CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Viral contamination of biotech product facilities is a potentially devastating manufacturing risk and, unfortunately, is more common than is generally reported or previously appreciated. Although viral contaminants of biotech products are thought to originate principally from biological raw materials, all potential process risks merit evaluation. Limitations to existing methods for virus detection are becoming evident as emerging viruses have contaminated facilities and disrupted supplies of critical products. New technologies, such as broad-based polymerase chain reaction screens for multiple virus types, are increasingly becoming available to detect adventitious viral contamination and thus, mitigate risks to biotech products and processes. Further, the industry embrace of quality risk management that promotes improvements in testing stratagems, enhanced viral inactivation methods for raw materials, implementation and standardization of robust viral clearance procedures, and efforts to learn from both epidemiologic screening of raw material sources and from the experience of other manufacturers with regard to this problem will serve to enhance the safety of biotech products available to patients. Based on this evolving landscape, we propose a set of principles for manufacturers of biotech products: Pillars of Risk Mitigation for Viral Contamination of Biotech Products.

  16. Kant's Theory of virtue

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2012-01-01

    Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)......Anmeldelse af Anne Margaret Baxleys bog: "Kant's Thery of Virtue. The Value of Autocracy" (Cambridge University Press, 2010)...

  17. On the long term climatology and trends of heat and cold waves over ...

    Indian Academy of Sciences (India)

    10

    shown significant decreasing trend in heat waves (2 stations from north India ..... Cambridge University Press, Cambridge UK and New York N Y USA 582 pp. ... Board, Department of Science and Technology (SERB-DST), New Delhi, India.

  18. Stanislav Markus. Property, Predation, and Protection: Piranha Capitalism in Russia and Ukraine

    Directory of Open Access Journals (Sweden)

    Paul Babie

    2016-09-01

    Full Text Available Stanislav Markus. Property, Predation, and Protection: Piranha Capitalism in Russia and Ukraine. Cambridge: Cambridge UP, 2015. xii, 244 pp. Illustrations. Tables. Bibliography. Index. $95.00, cloth.

  19. 75 FR 8740 - Notice of Intent to Repatriate a Cultural Item: Peabody Museum of Archaeology and Ethnology...

    Science.gov (United States)

    2010-02-25

    ... Ethnology, Harvard University, Cambridge, MA AGENCY: National Park Service, Interior. ACTION: Notice. Notice... of Archaeology and Ethnology, Harvard University, Cambridge, MA, that meets the definition of... California; and Wilton Rancheria, California. Officials of the Peabody Museum of Archaeology and Ethnology...

  20. Wind Tunnel Blockage Corrections for Propellors

    Science.gov (United States)

    2007-01-01

    aerodynamicists to explore propeller blockage corrections. In one of his early publications, The Elements of Aerofoil and Airscrew Theory, Glauert...REFERENCES [1] Glauert, H., The Elements of Aerofoil and Airscrew Theory, Cambridge University Press, Cambridge, England, Second Edition, 1947