WorldWideScience

Sample records for box model studies

  1. Thermohaline circulation stability: a box model study - Part I: uncoupled model

    CERN Document Server

    Lucarini, V; Lucarini, Valerio; Stone, Peter H.

    2004-01-01

    A thorough analysis of the stability of the uncoupled Rooth interhemispheric 3-box model of thermohaline circulation (THC) is presented. The model consists of a northern high latitudes box, a tropical box, and a southern high latitudes box, which respectively correspond to the northern, tropical and southern Atlantic ocean. We adopt restoring boundary conditions for the temperature variables and flux boundary conditions for the salinity variables. We study how the strength of THC changes when the system undergoes forcings that are analogous to those of global warming conditions by applying to the equilibrium state perturbations to the moisture and heat fluxes into the three boxes. In each class of experiments, we determine, using suitably de- fined metrics, the boundary dividing the set of forcing scenarios that lead the system to equilibria characterized by a THC pattern similar to the present one, from those that drive the system to equilibria with a reversed THC. Fast increases in the moisture flux into th...

  2. PHOTOCHEMICAL BOX MODEL (PBM)

    Science.gov (United States)

    This magnetic tape contains the FORTRAN source code, sample input data, and sample output data for the Photochemical Box Model (PBM). The PBM is a simple stationary single-cell model with a variable height lid designed to provide volume-integrated hour averages of O3 and other ph...

  3. Thermohaline circulation stability: a box model study - Part II: coupled atmosphere-ocean model

    CERN Document Server

    Lucarini, V; Lucarini, Valerio; Stone, Peter H.

    2004-01-01

    A thorough analysis of the stability of a coupled version of an inter-hemispheric 3-box model of Thermohaline Circulation (THC) is presented. This study follows a similarly structured analysis on an uncoupled version of the same model presented in Part I. We study how the strength of THC changes when the system undergoes forcings representing global warming conditions. Each perturbation to the initial equilibrium is characterized by the total radiative forcing realized, by the rate of increase, and by the North-South asymmetry. The choice of suitably defined metrics allows us to determine the boundary dividing the set of radiative forcing scenarios that lead the system to equilibria characterized by a THC pattern similar to the present one, from those that drive the system to equilibria where the THC is reversed. We also consider different choices for the atmospheric transport parameterizations and for the ratio between the high latitude to tropical radiative forcing. We generally find that fast forcings are ...

  4. Marine Ecosystem Modeling Beyond the Box: Using GIS to Study Carbon Fluxes in a Coastal Ecosystem

    International Nuclear Information System (INIS)

    Studies of carbon fluxes in marine ecosystems are often done by using box model approaches with basin size boxes, or highly resolved 3D models, and an emphasis on the pelagic component of the ecosystem. Those approaches work well in the ocean proper, but can give rise to considerable problems when applied to coastal systems, because of the scale of certain ecological niches and the fact that benthic organisms are the dominant functional group of the ecosystem. In addition, 3D models require an extensive modeling effort. In this project, an intermediate approach based on a high resolution (20x20 m) GIS data-grid has been developed for the coastal ecosystem in the Laxemar area (Baltic Sea, Sweden) based on a number of different site investigations. The model has been developed in the context of a safety assessment project for a proposed nuclear waste repository, in which the fate of hypothetically released radionuclides from the planned repository is estimated. The assessment project requires not only a good understanding of the ecosystem dynamics at the site, but also quantification of stocks and flows of matter in the system. The data-grid was then used to set up a carbon budget describing the spatial distribution of biomass, primary production, net ecosystem production and thus where carbon sinks and sources are located in the area. From these results, it was clear that there was a large variation in ecosystem characteristics within the basins and, on a larger scale, that the inner areas are net producing and the outer areas net respiring, even in shallow phyto benthic communities. Benthic processes had a similar or larger influence on carbon fluxes as advective processes in inner areas, whereas the opposite appears to be true in the outer basins. As many radionuclides are expected to follow the pathways of organic matter in the environment, these findings enhance our abilities to realistically describe and predict their fate in the ecosystem

  5. Impact of aircraft exhaust on the atmosphere. Box model studies and 3-D mesoscale numerical case studies of seasonal differences

    Energy Technology Data Exchange (ETDEWEB)

    Petry, H.; Ebel, A.; Franzkowiak, V.; Hendricks, J.; Lippert, E.; Moellhoff, M. [Koeln Univ. (Germany). Inst. fuer Geophysik und Meteorologie

    1997-12-31

    The impact of aircraft emissions released in the tropopause region on atmospheric trace gases as O{sub 3} or HNO{sub 3} is investigated by means of model studies. Special emphasis is drawn on seasonal effects. A box model is applied as well as a 3-D mesoscale chemistry transport model. These model studies show that the impact of aircraft emissions on ozone in the tropopause region is much stronger in summer than in late autumn with a difference of one order of magnitude. (author) 14 refs.

  6. Model Equations: "Black Box" Reconstruction

    Science.gov (United States)

    Bezruchko, Boris P.; Smirnov, Dmitry A.

    Black box reconstruction is both the most difficult and the most tempting modelling problem when any prior information about an appropriate model structure is lacking. An intriguing thing is that a model capable of reproducing an observed behaviour or predicting further evolution should be obtained only from an observed time series, i.e. "from nothing" at first sight. Chances for a success are not large. Even more so, a "good" model would become a valuable tool to characterise an object and understand its dynamics. Lack of prior information causes one to utilise universal model structures, e.g. artificial neural networks, radial basis functions and algebraic polynomials are included in the right-hand sides of dynamical model equations. Such models are often multi-dimensional and involve quite many free parameters.

  7. Numerical study on the ozone formation inside street canyons using a chemistry box model

    Institute of Scientific and Technical Information of China (English)

    Chun-Ho Liu; Dennis Y. C. Leung

    2008-01-01

    Tropospheric ozone is a secondary air pollutant produced in the presence of nitrogen oxides, volatile organic compounds (VOCs), and solar radiation. In an urban environment, ground-level vehicular exhaust is the major anthropogenic source of ozone precursors. In the cases of street canyons, pollutant dilution is weakened by the surrounding buildings that create localized high concentration of nitrogen oxides and VOCs, and thus leads to high potential of ozone formation. By considering the major physical and chemical processes, a chemistry box model is employed to investigate the characteristics of ozone formation due to vehicular exhaust inside street canyons under the worst case scenario, i.e. the calm wind condition. It is found that a high level of ozone concentration, of the order of 100 ppbv and higher, would occur inside the street canyons, in particular, when the emission rate (concentration) ratio of VOCs to nitrogen oxides is greater than 10. This elevated ozone concentration appears at the transition from VOCs to nitrogen oxides sensitivity and may extend to a few hundreds.

  8. Grey Box Modelling of Hydrological Systems

    DEFF Research Database (Denmark)

    Thordarson, Fannar Ørn

    intervals. The thesis illustrates three performance measures for this performance evaluations: reliability, sharpness and resolution. For decision making, a performance criterion is preferred that quantifies all of these measures in a single number, and for that the quantile skill score criterion is...... equations, and a black box model, which relates to models that are obtained statistically from input-output relations. Grey box model consists of a system description, defined by a finite set of stochastic differential equations, and an observation equation. Together, system and observation equations...... lack of fit in state space formulation, and further support decisions for a model expansion. By using stochastic differential equations to formulate the dynamics of the hydrological system, either the complexity of the model can be increased by including the necessary hydrological processes in the...

  9. Physical Modeling Modular Boxes: PHOXES

    DEFF Research Database (Denmark)

    Gelineck, Steven; Serafin, Stefania

    2010-01-01

    This paper presents the development of a set of musical instruments, which are based on known physical modeling sound synthesis techniques. The instruments are modular, meaning that they can be combined in various ways. This makes it possible to experiment with physical interaction and sonic...

  10. Grey-box modelling of pharmacokinetic/pharmacodynamic systems

    DEFF Research Database (Denmark)

    Tornøe, Christoffer Wenzel; Jacobsen, Judith L; Pedersen, Oluf;

    2004-01-01

    Grey-box pharmacokinetic/pharmacodynamic (PK/PD) modelling is presented as a promising way of modelling PK/PD systems. The concept behind grey-box modelling is based on combining physiological knowledge along with information from data in the estimation of model parameters. Grey-box modelling...

  11. Box model for channels of human migration

    CERN Document Server

    Vitanov, Nikolay K

    2016-01-01

    We discuss a mathematical model of migration channel based on the truncated Waring distribution. The truncated Waring distribution is obtained for a more general model of motion of substance through a channel containing finite number of boxes. The model is applied then for case of migrants moving through a channel consisting of finite number of countries or cities. The number of migrants in the channel strongly depends on the number of migrants that enter the channel through the country of entrance. It is shown that if the final destination country is very popular then large percentage of migrants may concentrate there.

  12. Boxed skew plane partition and integrable phase model

    International Nuclear Information System (INIS)

    We study the relation between the boxed skew plane partition and the integrable phase model. We introduce a generalization of a scalar product of the phase model and calculate it in two ways: the first one in terms of the skew Schur functions, and the other one by use of the commutation relations of operators. In both cases, a generalized scalar product is expressed as a determinant. We show that a special choice of the spectral parameters of a generalized scalar product gives the generating function of the boxed skew plane partition

  13. Black-box modeling to estimate tissue temperature during radiofrequency catheter cardiac ablation: feasibility study on an agar phantom model

    International Nuclear Information System (INIS)

    The aim of this work was to study linear deterministic models to predict tissue temperature during radiofrequency cardiac ablation (RFCA) by measuring magnitudes such as electrode temperature, power and impedance between active and dispersive electrodes. The concept involves autoregressive models with exogenous input (ARX), which is a particular case of the autoregressive moving average model with exogenous input (ARMAX). The values of the mode parameters were determined from a least-squares fit of experimental data. The data were obtained from radiofrequency ablations conducted on agar models with different contact pressure conditions between electrode and agar (0 and 20 g) and different flow rates around the electrode (1, 1.5 and 2 L min−1). Half of all the ablations were chosen randomly to be used for identification (i.e. determination of model parameters) and the other half were used for model validation. The results suggest that (1) a linear model can be developed to predict tissue temperature at a depth of 4.5 mm during RF cardiac ablation by using the variables applied power, impedance and electrode temperature; (2) the best model provides a reasonably accurate estimate of tissue temperature with a 60% probability of achieving average errors better than 5 °C; (3) substantial errors (larger than 15 °C) were found only in 6.6% of cases and were associated with abnormal experiments (e.g. those involving the displacement of the ablation electrode) and (4) the impact of measuring impedance on the overall estimate is negligible (around 1 °C)

  14. Study of WATCH GRB error boxes

    DEFF Research Database (Denmark)

    Gorosabel, J.; Castro-Tirado, A. J.; Lund, Niels;

    1995-01-01

    We have studied the first WATCH GRB Catalogue ofγ-ray Bursts in order to find correlations between WATCH GRB error boxes and a great variety of celestial objects present in 33 different catalogues. No particular class of objects has been found to be significantly correlated with the WATCH GRBs....

  15. Software sensors based on the grey-box modelling approach

    DEFF Research Database (Denmark)

    Carstensen, J.; Harremoës, P.; Strube, Rune

    1996-01-01

    In recent years the grey-box modelling approach has been applied to wastewater transportation and treatment Grey-box models are characterized by the combination of deterministic and stochastic terms to form a model where all the parameters are statistically identifiable from the on......-box model for the specific dynamics is identified. Similarly, an on-line software sensor for detecting the occurrence of backwater phenomena can be developed by comparing the dynamics of a flow measurement with a nearby level measurement. For treatment plants it is found that grey-box models applied to on......-line measurements. With respect to the development of software sensors, the grey-box models possess two important features. Firstly, the on-line measurements can be filtered according to the grey-box model in order to remove noise deriving from the measuring equipment and controlling devices. Secondly, the grey...

  16. Cash Flow Prediction Using a Grey-Box Model

    OpenAIRE

    Pang, Yang; Opong, Kwaku; Moutinho, Luia; Li, Yun

    2015-01-01

    This paper tackles the problem of financial forecasting by extending methods developed in automation, engineering and computing science. Current methods existing in the literature for firm-level cash flows are first analysed. Then a grey-box modelling method is developed to elevate the performance of cash-flow prediction. Linear panel data modelling is used as a benchmark model. Experiments with out-of-sample tests are used to validate the grey-box approach. Encouragingly, nonlinear grey-box ...

  17. A box model study on photochemical interactions between VOCs and reactive halogen species in the marine boundary layer

    Directory of Open Access Journals (Sweden)

    K. Toyota

    2004-01-01

    Full Text Available A new chemical scheme is developed for the multiphase photochemical box model SEAMAC (size-SEgregated Aerosol model for Marine Air Chemistry to investigate photochemical interactions between volatile organic compounds (VOCs and reactive halogen species in the marine boundary layer (MBL. Based primarily on critically evaluated kinetic and photochemical rate parameters as well as a protocol for chemical mechanism development, the new scheme has achieved a near-explicit description of oxidative degradation of up to C3-hydrocarbons (CH4, C2H6, C3H8, C2H4, C3H6, and C2H2 initiated by reactions with OH radicals, Cl- and Br-atoms, and O3. Rate constants and product yields for reactions involving halogen species are taken from the literature where available, but the majority of them need to be estimated. In particular, addition reactions of halogen atoms with alkenes will result in forming halogenated organic intermediates, whose photochemical loss rates are carefully evaluated in the present work. Model calculations with the new chemical scheme reveal that the oceanic emissions of acetaldehyde (CH3CHO and alkenes (especially C3H6 are important factors for regulating reactive halogen chemistry in the MBL by promoting the conversion of Br atoms into HBr or more stable brominated intermediates in the organic form. The latter include brominated hydroperoxides, bromoacetaldehyde, and bromoacetone, which sequester bromine from a reactive inorganic pool. The total mixing ratio of brominated organic species thus produced is likely to reach 10-20% or more of that of inorganic gaseous bromine species over wide regions over the ocean. The reaction between Br atoms and C2H2 is shown to be unimportant for determining the degree of bromine activation in the remote MBL. These results imply that reactive halogen chemistry can mediate a link between the oceanic emissions of VOCs and the behaviors of compounds that are sensitive to halogen chemistry such as dimethyl

  18. A box model study on photochemical interactions between VOCs and reactive halogen species in the marine boundary layer

    Directory of Open Access Journals (Sweden)

    K. Toyota

    2003-09-01

    Full Text Available A new chemical scheme is developed for the multiphase photochemical box model SEAMAC (size-SEgregated Aerosol model for Marine Air Chemistry to investigate photochemical interactions between volatile organic compounds (VOCs and reactive halogen species in the marine boundary layer (MBL. Based primarily on critically evaluated kinetic and photochemical rate parameters as well as a protocol for chemical mechanism development, the new scheme has achieved a near-explicit treatment of oxidative degradation of up to C3-hydrocarbons CH4, C2H6, C3H8, C2H4, C3H6, and C2H2 initiated by reactions with OH radicals, Cl- and Br-atoms, and O3. Rate constants and product yields for reactions involving halogen species are taken from the literature where available, but the majority of them need to be estimated. In particular, addition reactions of halogen atoms with alkenes will result in the formation of halogenated organic intermediates, whose photochemical loss rates are carefully evaluated in the present work. Model calculations with the new chemical scheme reveal that the oceanic emissions of acetaldehyde (CH3CHO and alkenes (especially C3H6 are important factors for regulating reactive halogen chemistry in the MBL by promoting the conversion of Br atoms into HBr or more stable brominated intermediates in the organic form. The latter include brominated hydroperoxides, bromoacetaldehyde, and bromoacetone, which sequester bromine from reactive inorganic pool. The total mixing ratio of brominated organic species thus produced is likely to reach 10-20% or more of that of inorganic gaseous bromine species over wide regions over the ocean. On the other hand, the reaction between Br atoms and C2H2 is unimportant for determining the degree of bromine activation in the

  19. Gray-box modelling approach for description of storage tunnel

    DEFF Research Database (Denmark)

    Harremoës, Poul; Carstensen, Jacob

    1999-01-01

    The dynamics of a storage tunnel is examined using a model based on on-line measured data and a combination of simple deterministic and black-box stochastic elements. This approach, called gray-box modeling, is a new promising methodology for giving an on-line state description of sewer systems. ...... and implemented in a SCADA system because the most important information on the specific system is provided on-line......The dynamics of a storage tunnel is examined using a model based on on-line measured data and a combination of simple deterministic and black-box stochastic elements. This approach, called gray-box modeling, is a new promising methodology for giving an on-line state description of sewer systems...

  20. A Three-Box Model of Thermohaline Circulation under the Energy Constraint

    International Nuclear Information System (INIS)

    The driving mechanism of thermohaline circulation is still a controversial topic in physical oceanography. Classic theory is based on Stommel's two-box model under buoyancy constraint. Recently, Guan and Huang proposed a new viewpoint in the framework of energy constraint with a two-box model. We extend it to a three-box model, including the effect of wind-driven circulation. Using this simple model, we further study how ocean mixing impacts on thermohaline circulation under the energy constraint. (geophysics, astronomy, and astrophysics)

  1. Probability boxes on totally preordered spaces for multivariate modelling

    CERN Document Server

    Troffaes, Matthias C M; 10.1016/j.ijar.2011.02.001

    2011-01-01

    A pair of lower and upper cumulative distribution functions, also called probability box or p-box, is among the most popular models used in imprecise probability theory. They arise naturally in expert elicitation, for instance in cases where bounds are specified on the quantiles of a random variable, or when quantiles are specified only at a finite number of points. Many practical and formal results concerning p-boxes already exist in the literature. In this paper, we provide new efficient tools to construct multivariate p-boxes and develop algorithms to draw inferences from them. For this purpose, we formalise and extend the theory of p-boxes using Walley's behavioural theory of imprecise probabilities, and heavily rely on its notion of natural extension and existing results about independence modeling. In particular, we allow p-boxes to be defined on arbitrary totally preordered spaces, hence thereby also admitting multivariate p-boxes via probability bounds over any collection of nested sets. We focus on t...

  2. The approximate scaling law of the cochlea box model.

    Science.gov (United States)

    Vetesník, A; Nobili, R

    2006-12-01

    The hydrodynamic box-model of the cochlea is reconsidered here for the primary purpose of studying in detail the approximate scaling law that governs tonotopic responses in the frequency domain. "Scaling law" here means that any two solutions representing waveforms elicited by tones of equal amplitudes differ only by a complex factor depending on frequency. It is shown that this property holds with excellent approximation almost all along the basilar membrane (BM) length, with the exception of a small region adjacent to the BM base. The analytical expression of the approximate law is explicitly given and compared to numerical solutions carried out on a virtually exact implementation of the model. It differs significantly from that derived by Sondhi in 1978, which suffers from an inaccuracy in the hyperbolic approximation of the exact Green's function. Since the cochleae of mammals do not exhibit the scaling properties of the box model, the subject presented here may appear to be just an academic exercise. The results of our study, however, are significant in that a more general scaling law should hold for real cochleae. To support this hypothesis, an argument related to the problem of cochlear amplifier-gain stabilization is advanced. PMID:17008036

  3. A tool box for implementing supersymmetric models

    CERN Document Server

    Staub, Florian; Porod, Werner; Speckner, Christian

    2011-01-01

    We present a framework for performing a comprehensive analysis of a large class of supersymmetric models, including spectrum calculation, dark matter studies and collider phenomenology. To this end, the respective model is defined in an easy and straightforward way using the \\Mathematica package SARAH. SARAH then generates model files for CalcHep which can be used with MicrOmegas as well as model files for WHIZARD and OMEGA. In addition, Fortran source code for SPheno is created which facilitates the determination of the particle spectrum using two-loop renormalization group equations and one-loop corrections to the masses. As an additional feature, the generated SPheno code can write out input files suitable for use with HiggsBounds to apply bounds coming from the Higgs searches to the model. Combining all program provides a closed chain from model building to phenomenology.

  4. A tool box for implementing supersymmetric models

    Science.gov (United States)

    Staub, Florian; Ohl, Thorsten; Porod, Werner; Speckner, Christian

    2012-10-01

    We present a framework for performing a comprehensive analysis of a large class of supersymmetric models, including spectrum calculation, dark matter studies and collider phenomenology. To this end, the respective model is defined in an easy and straightforward way using the Mathematica package SARAH. SARAH then generates model files for CalcHep which can be used with micrOMEGAs as well as model files for WHIZARD and O'Mega. In addition, Fortran source code for SPheno is created which facilitates the determination of the particle spectrum using two-loop renormalization group equations and one-loop corrections to the masses. As an additional feature, the generated SPheno code can write out input files suitable for use with HiggsBounds to apply bounds coming from the Higgs searches to the model. Combining all programs provides a closed chain from model building to phenomenology. Program summary Program title: SUSY Phenomenology toolbox. Catalog identifier: AEMN_v1_0. Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEMN_v1_0.html. Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland. Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html. No. of lines in distributed program, including test data, etc.: 140206. No. of bytes in distributed program, including test data, etc.: 1319681. Distribution format: tar.gz. Programming language: Autoconf, Mathematica. Computer: PC running Linux, Mac. Operating system: Linux, Mac OS. Classification: 11.6. Nature of problem: Comprehensive studies of supersymmetric models beyond the MSSM is considerably complicated by the number of different tasks that have to be accomplished, including the calculation of the mass spectrum and the implementation of the model into tools for performing collider studies, calculating the dark matter density and checking the compatibility with existing collider bounds (in particular, from the Higgs searches). Solution method: The

  5. A Grey Box Model for the Hydraulics in a Creek

    DEFF Research Database (Denmark)

    Jonsdottir, Harpa; Jacobsen, Judith L.; Madsen, Henrik

    1998-01-01

    The Saint-Venant equation of mass balance is used to derive a stochastics lumped model, describing the dynamics of a cross-sectional area in a river. The unknown parameters of the model are estimated by combining the physical equation with a set of data, a method known as grey box modelling. The ...

  6. Inferring 3D Articulated Models for Box Packaging Robot

    CERN Document Server

    Yang, Heran; Cong, Matthew; Saxena, Ashutosh

    2011-01-01

    Given a point cloud, we consider inferring kinematic models of 3D articulated objects such as boxes for the purpose of manipulating them. While previous work has shown how to extract a planar kinematic model (often represented as a linear chain), such planar models do not apply to 3D objects that are composed of segments often linked to the other segments in cyclic configurations. We present an approach for building a model that captures the relation between the input point cloud features and the object segment as well as the relation between the neighboring object segments. We use a conditional random field that allows us to model the dependencies between different segments of the object. We test our approach on inferring the kinematic structure from partial and noisy point cloud data for a wide variety of boxes including cake boxes, pizza boxes, and cardboard cartons of several sizes. The inferred structure enables our robot to successfully close these boxes by manipulating the flaps.

  7. Opening Pandora's Box: The impact of open system modeling on interpretations of anoxia

    Science.gov (United States)

    Hotinski, Roberta M.; Kump, Lee R.; Najjar, Raymond G.

    2000-06-01

    The geologic record preserves evidence that vast regions of ancient oceans were once anoxic, with oxygen levels too low to sustain animal life. Because anoxic conditions have been postulated to foster deposition of petroleum source rocks and have been implicated as a kill mechanism in extinction events, the genesis of such anoxia has been an area of intense study. Most previous models of ocean oxygen cycling proposed, however, have either been qualitative or used closed-system approaches. We reexamine the question of anoxia in open-system box models in order to test the applicability of closed-system results over long timescales and find that open and closed-system modeling results may differ significantly on both short and long timescales. We also compare a scenario with basinwide diffuse upwelling (a three-box model) to a model with upwelling concentrated in the Southern Ocean (a four-box model). While a three-box modeling approach shows that only changes in high-latitude convective mixing rate and character of deepwater sources are likely to cause anoxia, four-box model experiments indicate that slowing of thermohaline circulation, a reduction in wind-driven upwelling, and changes in high-latitude export production may also cause dysoxia or anoxia in part of the deep ocean on long timescales. These results suggest that box models must capture the open-system and vertically stratified nature of the ocean to allow meaningful interpretations of long-lived episodes of anoxia.

  8. Gray-box modelling approach for description of storage tunnel

    DEFF Research Database (Denmark)

    Harremoës, Poul; Carstensen, Jacob

    1999-01-01

    The dynamics of a storage tunnel is examined using a model based on on-line measured data and a combination of simple deterministic and black-box stochastic elements. This approach, called gray-box modeling, is a new promising methodology for giving an on-line state description of sewer systems...... inertia of the water in the overflow structures. The capacity of a pump draining the storage tunnel is estimated for two different rain events, revealing that the pump was malfunctioning during the first rain event. The proposed modeling approach can be used in automated online surveillance and control...

  9. A review of presented mathematical models in Parkinson's disease: black- and gray-box models.

    Science.gov (United States)

    Sarbaz, Yashar; Pourakbari, Hakimeh

    2016-06-01

    Parkinson's disease (PD), one of the most common movement disorders, is caused by damage to the central nervous system. Despite all of the studies on PD, the formation mechanism of its symptoms remained unknown. It is still not obvious why damage only to the substantia nigra pars compacta, a small part of the brain, causes a wide range of symptoms. Moreover, the causes of brain damages remain to be fully elucidated. Exact understanding of the brain function seems to be impossible. On the other hand, some engineering tools are trying to understand the behavior and performance of complex systems. Modeling is one of the most important tools in this regard. Developing quantitative models for this disease has begun in recent decades. They are very effective not only in better understanding of the disease, offering new therapies, and its prediction and control, but also in its early diagnosis. Modeling studies include two main groups: black-box models and gray-box models. Generally, in the black-box modeling, regardless of the system information, the symptom is only considered as the output. Such models, besides the quantitative analysis studies, increase our knowledge of the disorders behavior and the disease symptoms. The gray-box models consider the involved structures in the symptoms appearance as well as the final disease symptoms. These models can effectively save time and be cost-effective for the researchers and help them select appropriate treatment mechanisms among all possible options. In this review paper, first, efforts are made to investigate some studies on PD quantitative analysis. Then, PD quantitative models will be reviewed. Finally, the results of using such models are presented to some extent. PMID:26546075

  10. Soil moisture simulations using a meso-scale hydrological model and box modelling approach

    Czech Academy of Sciences Publication Activity Database

    Šípek, Václav; Tesař, Miroslav

    St. Petersburg : ERB, 2012 - (Vuglinsky, V.; Kopaliani, Z.; Zhuravin, S.). s. 41-45 [Biennial Conference ERB 2012 on Studies of Hydrological Processes in Research Basins. Current Challenges and Prospects /14./. 17.09.2012-20.09.2012, St. Petersburg] R&D Projects: GA AV ČR IAA300600901; GA ČR GA205/08/1174 Institutional support: RVO:67985874 Keywords : soil moisture * distributed hydrological model ling * box model ling Subject RIV: DA - Hydrology ; Limnology

  11. Gray-Box Modeling of a Pneumatic Servo-Valve

    Directory of Open Access Journals (Sweden)

    Mojtaba Aghamirsalim

    2010-12-01

    Full Text Available This paper presents the evaluation as well as the combined analytical andexperimental identification (gray box identification of a servo-valve torque motor as thedirectional valve applied in a pneumatic actuator. Based on analytical modelling, a simplelinear parametric model with transfer function and block diagram is developed. Next, thestatic and dynamic characteristics of the torque motor are obtained from experimentalobservations. The characteristics confirm the desired linear behaviour of the torque motor.Hence, linearized coefficients from a best curve fitting of static characteristics can bederived. Classical methods of identification are applied on the frequency and stepresponses obtained from a set of tests on the torque motor. Obtained tests results based onparsimony principle and model order of analytical investigations are then implemented toderive the best identified transfer function to describe the performance of the servo-valvetorque motor. Design parameters are estimated with the comparison of the experimentaland analytical models. These parameters can be implemented with acceptable accuracy forservo control studies of pneumatic actuators.

  12. Gray-Box Modeling of a Pneumatic Servo-Valve

    OpenAIRE

    Mojtaba Aghamirsalim; Hosein Farahmandzad; Farhad Toorani

    2010-01-01

    This paper presents the evaluation as well as the combined analytical andexperimental identification (gray box identification) of a servo-valve torque motor as thedirectional valve applied in a pneumatic actuator. Based on analytical modelling, a simplelinear parametric model with transfer function and block diagram is developed. Next, thestatic and dynamic characteristics of the torque motor are obtained from experimentalobservations. The characteristics confirm the desired linear behaviour ...

  13. A white-box model of S-shaped and double S-shaped single-species population growth.

    Science.gov (United States)

    Kalmykov, Lev V; Kalmykov, Vyacheslav L

    2015-01-01

    Complex systems may be mechanistically modelled by white-box modeling with using logical deterministic individual-based cellular automata. Mathematical models of complex systems are of three types: black-box (phenomenological), white-box (mechanistic, based on the first principles) and grey-box (mixtures of phenomenological and mechanistic models). Most basic ecological models are of black-box type, including Malthusian, Verhulst, Lotka-Volterra models. In black-box models, the individual-based (mechanistic) mechanisms of population dynamics remain hidden. Here we mechanistically model the S-shaped and double S-shaped population growth of vegetatively propagated rhizomatous lawn grasses. Using purely logical deterministic individual-based cellular automata we create a white-box model. From a general physical standpoint, the vegetative propagation of plants is an analogue of excitation propagation in excitable media. Using the Monte Carlo method, we investigate a role of different initial positioning of an individual in the habitat. We have investigated mechanisms of the single-species population growth limited by habitat size, intraspecific competition, regeneration time and fecundity of individuals in two types of boundary conditions and at two types of fecundity. Besides that, we have compared the S-shaped and J-shaped population growth. We consider this white-box modeling approach as a method of artificial intelligence which works as automatic hyper-logical inference from the first principles of the studied subject. This approach is perspective for direct mechanistic insights into nature of any complex systems. PMID:26038717

  14. Observational semantics of the Prolog Resolution Box Model

    CERN Document Server

    Deransart, Pierre; Ferrand, Gérard

    2007-01-01

    This paper specifies an observational semantics and gives an original presentation of the Byrd box model. The approach accounts for the semantics of Prolog tracers independently of a particular Prolog implementation. Prolog traces are, in general, considered as rather obscure and difficult to use. The proposed formal presentation of its trace constitutes a simple and pedagogical approach for teaching Prolog or for implementing Prolog tracers. It is a form of declarative specification for the tracers. The trace model introduced here is only one example to illustrate general problems relating to tracers and observing processes. Observing processes know, from observed processes, only their traces. The issue is then to be able to reconstitute, by the sole analysis of the trace, part of the behaviour of the observed process, and if possible, without any loss of information. As a matter of fact, our approach highlights qualities of the Prolog resolution box model which made its success, but also its insufficiencies...

  15. POD Model Reconstruction for Gray-Box Fault Detection

    Science.gov (United States)

    Park, Han; Zak, Michail

    2007-01-01

    Proper orthogonal decomposition (POD) is the mathematical basis of a method of constructing low-order mathematical models for the "gray-box" fault-detection algorithm that is a component of a diagnostic system known as beacon-based exception analysis for multi-missions (BEAM). POD has been successfully applied in reducing computational complexity by generating simple models that can be used for control and simulation for complex systems such as fluid flows. In the present application to BEAM, POD brings the same benefits to automated diagnosis. BEAM is a method of real-time or offline, automated diagnosis of a complex dynamic system.The gray-box approach makes it possible to utilize incomplete or approximate knowledge of the dynamics of the system that one seeks to diagnose. In the gray-box approach, a deterministic model of the system is used to filter a time series of system sensor data to remove the deterministic components of the time series from further examination. What is left after the filtering operation is a time series of residual quantities that represent the unknown (or at least unmodeled) aspects of the behavior of the system. Stochastic modeling techniques are then applied to the residual time series. The procedure for detecting abnormal behavior of the system then becomes one of looking for statistical differences between the residual time series and the predictions of the stochastic model.

  16. Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases

    Institute of Scientific and Technical Information of China (English)

    Weihua Zhou; Wenyi Wei; Yi Sun

    2013-01-01

    The SCF (SKP1 (S-phase-kinase-associated protein 1),Cullin-1,F-box protein) E3 ubiquitin ligases,the founding member of Cullin-RING ligases (CRLs),are the largest family of E3 ubiquitin ligases in mammals.Each individual SCF E3 ligase consists of one adaptor protein SKP1,one scaffold protein cullin-1 (the first family member of the eight cullins),one F-box protein out of 69 family members,and one out of two RING (Really Interesting New Gene) family proteins RBX1/ROC1 or RBX2/ROC2/SAG/RNF7.Various combinations of these four components construct a large number of SCF E3s that promote the degradation of many key regulatory proteins in cell-context,temporally,and spatially dependent manners,thus controlling precisely numerous important cellular processes,including cell cycle progression,apoptosis,gene transcription,signal transduction,DNA replication,maintenance of genome integrity,and tumorigenesis.To understand how the SCF E3 ligases regulate these cellular processes and embryonic development under in vivo physiological conditions,a number of mouse models with transgenic (Tg) expression or targeted deletion of components of SCF have been established and characterized.In this review,we will provide a brief introduction to the ubiquitin-proteasome system (UPS) and the SCF E3 ubiquitin ligases,followed by a comprehensive overview on the existing Tg and knockout (KO) mouse models of the SCF E3s,and discuss the role of each component in mouse embryogenesis,cell proliferation,apoptosis,carcinogenesis,as well as other pathogenic processes associated with human diseases.We will end with a brief discussion on the future directions of this research area and the potential applications of the knowledge gained to more effective therapeutic interventions of human diseases.

  17. A comparison of classical mechanics models and finite element simulation of elastically tailored wing boxes

    Science.gov (United States)

    Rehfield, Lawrence W.; Pickings, Richard D.; Chang, Stephen; Holl, Michael

    1991-01-01

    Structural tailoring concepts were developed to create wings with elastically produced camber for the purpose of increasing lift during takeoff conditions. Simple models based upon enhancements to the thin walled composite beam theory of Rehfield were developed to investigate prospects for elastic tailoring of the chordwise deformation of wing structures. The purpose here is to provide a comparison of the theoretical results with a finite element model for the bending method of producing camber. Finite element correlation studies were completed for two cases: a bonded unstiffened structural box, and a bolted unstiffened structural box. Results from these studies show an error of less than one percent for the bonded case and less than six percent for the bolted case in predicting camber curvature for the structural box. Examination of the results shows that the theory is very accurate for the cases studied and will provide an excellent basis for conducting further tailoring studies.

  18. A white-box model of S-shaped and double S-shaped single-species population growth

    OpenAIRE

    Kalmykov, Lev V.; Vyacheslav L. Kalmykov

    2015-01-01

    Complex systems may be mechanistically modelled by white-box modeling with using logical deterministic individual-based cellular automata. Mathematical models of complex systems are of three types: black-box (phenomenological), white-box (mechanistic, based on the first principles) and grey-box (mixtures of phenomenological and mechanistic models). Most basic ecological models are of black-box type, including Malthusian, Verhulst, Lotka–Volterra models. In black-box models, the individual-bas...

  19. PARAMETRIC STUDY OF SKEW ANGLE ON BOX GIRDER BRIDGE DECK

    OpenAIRE

    Shrikant D. Bobade *, Dr. Valsson Varghese

    2016-01-01

    Box girder bridge deck, is the most common type of bridges in world and India, it consists of several Slab or girders. The span in the direction of the roadway and connected across their tops and bottoms by a thin continuous structural stab, the longitudinal box girders can be made of steel or concrete. The Simple supported single span concrete bridge deck is presented in present study. Skewed bridges are suitable in highway design when the geometry of straight bridges is not possible. The sk...

  20. COMPUTER MODEL AND SIMULATION OF A GLOVE BOX PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    C. FOSTER; ET AL

    2001-01-01

    The development of facilities to deal with the disposition of nuclear materials at an acceptable level of Occupational Radiation Exposure (ORE) is a significant issue facing the nuclear community. One solution is to minimize the worker's exposure though the use of automated systems. However, the adoption of automated systems for these tasks is hampered by the challenging requirements that these systems must meet in order to be cost effective solutions in the hazardous nuclear materials processing environment. Retrofitting current glove box technologies with automation systems represents potential near-term technology that can be applied to reduce worker ORE associated with work in nuclear materials processing facilities. Successful deployment of automation systems for these applications requires the development of testing and deployment strategies to ensure the highest level of safety and effectiveness. Historically, safety tests are conducted with glove box mock-ups around the finished design. This late detection of problems leads to expensive redesigns and costly deployment delays. With wide spread availability of computers and cost effective simulation software it is possible to discover and fix problems early in the design stages. Computer simulators can easily create a complete model of the system allowing a safe medium for testing potential failures and design shortcomings. The majority of design specification is now done on computer and moving that information to a model is relatively straightforward. With a complete model and results from a Failure Mode Effect Analysis (FMEA), redesigns can be worked early. Additional issues such as user accessibility, component replacement, and alignment problems can be tackled early in the virtual environment provided by computer simulation. In this case, a commercial simulation package is used to simulate a lathe process operation at the Los Alamos National Laboratory (LANL). The Lathe process operation is

  1. Experimental Grey Box Model Identification of an Active Gas Bearing

    DEFF Research Database (Denmark)

    Theisen, Lukas Roy Svane; Pierart Vásquez, Fabián Gonzalo; Niemann, Hans Henrik;

    2014-01-01

    Gas bearings have inherent dynamics that gives rise to low damping and potential instability at certain rotational speeds. Required damping and stabilization properties can be achieved by active ow control if bearing parameters are known. This paper deals with identifacation of parameters in a...... dynamic model of an active gas bearing and subsequent control loop design. A grey box model is determined based on experiments where piezo actuated valves are used to perturb the journal and hence excite the rotor-bearing system. Such modelling from actuator to output is shown to effciently support...... controller design, in contrast to impact models that focus on resonance dynamics. The identified model is able to accurately reproduce the lateral dynamics of the rotor-bearing system in a desired operating range, in this case around the first two natural frequencies. The identified models are validated and...

  2. A white-box model of S-shaped and double S-shaped single-species population growth

    Directory of Open Access Journals (Sweden)

    Lev V. Kalmykov

    2015-05-01

    Full Text Available Complex systems may be mechanistically modelled by white-box modeling with using logical deterministic individual-based cellular automata. Mathematical models of complex systems are of three types: black-box (phenomenological, white-box (mechanistic, based on the first principles and grey-box (mixtures of phenomenological and mechanistic models. Most basic ecological models are of black-box type, including Malthusian, Verhulst, Lotka–Volterra models. In black-box models, the individual-based (mechanistic mechanisms of population dynamics remain hidden. Here we mechanistically model the S-shaped and double S-shaped population growth of vegetatively propagated rhizomatous lawn grasses. Using purely logical deterministic individual-based cellular automata we create a white-box model. From a general physical standpoint, the vegetative propagation of plants is an analogue of excitation propagation in excitable media. Using the Monte Carlo method, we investigate a role of different initial positioning of an individual in the habitat. We have investigated mechanisms of the single-species population growth limited by habitat size, intraspecific competition, regeneration time and fecundity of individuals in two types of boundary conditions and at two types of fecundity. Besides that, we have compared the S-shaped and J-shaped population growth. We consider this white-box modeling approach as a method of artificial intelligence which works as automatic hyper-logical inference from the first principles of the studied subject. This approach is perspective for direct mechanistic insights into nature of any complex systems.

  3. Analysis of Data on Xanthan Fermentation in Stationary Phase Using Black Box and Metabolic Network Models

    Institute of Scientific and Technical Information of China (English)

    马红武; 赵学明; 唐寅杰

    1999-01-01

    The xanthan fermentation data in the stationary phase was analyzed using the black box and the metabolic network models. The data consistency ls checked through the elemental balance in the black box model. In the metabolic network model, the metabolic flux distribution in the cell is calculated using the metabolic flux analysis method, then the maintenance coefficients is calculated.

  4. 太阳日总辐射量的Box-Jenkins模型%BOX-JENKINS MODEL FOR DAILY SOLAR RADIATION

    Institute of Scientific and Technical Information of China (English)

    王敏; 丁明

    2012-01-01

    基于天文辐射和日照率数据,采用系统辨识的方法建立了模拟太阳日总辐射量的BJ( Box-Jenkins)模型.该模型与传统的(A)ngstr(m)的日总辐射量的计算公式相比,模拟和预测效果更好.%Based on astronomical radiation and percentage of possible sunshine data, the BJ (Box-Jenkins) model for daily solar irradiation is established using system identification method. The simulation and the one-step forecast results of the BJ model are better than Angstrm formula of the calculation.

  5. A box model of the Arctic natural variability

    Science.gov (United States)

    Ou, Hsien-Wang

    2013-04-01

    We consider a box model of the Arctic system to examine its natural variability pertaining to the decadal Arctic Oscillation (AO) and the multidecadal Low-Frequency Oscillation (LFO). We distinguish the hierarchical order of the winter over the summer open-areas with only the former perturbing the sea-level pressure to effect coupled balances. From such balances, we discern two feedback loops on the winter open-area: a positive ice-flux feedback that elevates its overall variance and a negative buoyancy feedback that suppresses its low-frequency variance to render a decadal AO peak when subjected to white atmospheric noise. This negative buoyancy feedback may also reproduce observed phasing among LFO signals forced by the AMV (Atlantic Multidecadal Variability), thus resolving some outstanding questions. For the summer open-area, its variance is induced mainly by the winter forcings and insensitive to the base state. Its decadal signal merely reflects the preconditioning winter open-area, but its LFO variance is induced additionally and in comparable measure by the winter SAT (surface air temperature) through the latter's effect on the melt duration and the first-year ice thickness. As such, the summer open-area signal is dominantly multidecadal, which moreover is several times its winter counterpart, consistent with the observed disparity. Although the model is extremely crude, its explicit solution allows quantitative comparison with observations and the generally positive outcome suggests that the model has isolated the essential physics of the Arctic natural variability of our concern.

  6. Nutrient fluxes in the Changjiang River estuary and adjacent waters — a modified box model approach

    Science.gov (United States)

    Wang, Xiaohong; Yu, Zhiming; Fan, Wei; Song, Xiuxian; Cao, Xihua; Yuan, Yongquan

    2015-01-01

    To solve nutrient flux and budget among waters with distinct salinity difference for water-salt-nutrient budget, a traditional method is to build a stoichiometrically linked steady state model. However, the traditional way cannot cope appropriately with those without distinct salinity difference that parallel to coastline or in a complex current system, as the results would be highly affected by box division in time and space, such as the Changjiang (Yangtze) River estuary (CRE) and adjacent waters (30.75°2-31.75°N, 122°10'-123°20'E). Therefore, we developed a hydrodynamic box model based on the traditional way and the regional oceanic modeling system model (ROMS). Using data from four cruises in 2005, horizontal, vertical and boundary nutrient fluxes were calculated in the hydrodynamic box model, in which flux fields and the major controlling factors were studied. Results show that the nutrient flux varied greatly in season and space. Water flux outweighs the nutrient concentration in horizontal flux, and upwelling flux outweighs upward diffusion flux in vertical direction (upwelling flux and upward diffusion flux regions overlap largely all the year). Vertical flux in spring and summer are much greater than that in autumn and winter. The maximum vertical flux for DIP (dissolved inorganic phosphate) occurs in summer. Additional to the fluxes of the Changjiang River discharge, coastal currents, the Taiwan Warm Current, and the upwelling, nutrient flux inflow from the southern Yellow Sea and outflow southward are found crucial to nutrient budgets of the study area. Horizontal nutrient flux is controlled by physical dilution and confined to coastal waters with a little into the open seas. The study area acts as a conveyer transferring nutrients from the Yellow Sea to the East China Sea in the whole year. In addition, vertical nutrient flux in spring and summer is a main source of DIP. Therefore, the hydrodynamic ROMS-based box model is superior to the traditional

  7. Modelling segregation effects of heterogeneous emissions on ozone levels in idealised urban street canyons: Using photochemical box models

    International Nuclear Information System (INIS)

    Air quality models include representations of pollutant emissions, which necessarily entail spatial averaging to reflect the model grid size; such averaging may result in significant uncertainties and/or systematic biases in the model output. This study investigates such uncertainties, considering ozone concentrations in idealised street canyons within the urban canopy. A photochemical model with grid-averaged emissions of street canyons is compared with a multiple-box model considering each canyon independently. The results reveal that the averaged, ‘one-box’ model may significantly underestimate true (independent canyon mean) ozone concentrations for typical urban areas, and that the performance of the averaged model is improved for more ‘green’ and/or less trafficked areas. Our findings also suggest that the trends of 2005–2020 in emissions, in isolation, reduce the error inherent in the averaged-emissions treatment. These new findings may be used to evaluate uncertainties in modelled urban ozone concentrations when grid-averaged emissions are adopted. - Highlights: • Grid-based models adopting a grid-averaging scheme of emissions may result in model uncertainties. • Such uncertainties considering ozone levels in idealised street canyons are examined. • The one-box model significantly underestimates the street-level ozone abundance. • The performance of the one-box model is improved for more ‘green’ or less trafficked areas. • Future emission trends are expected to lead to the error in the one-box model approach falling. - A grid-based urban air quality model, if adopting a grid-averaging scheme of emissions from segregated street canyons, may significantly underestimate the street-level ozone abundance

  8. Economic analysis of open space box model utilization in spacecraft

    Science.gov (United States)

    Mohammad, Atif F.; Straub, Jeremy

    2015-05-01

    It is a known fact that the amount of data about space that is stored is getting larger on an everyday basis. However, the utilization of Big Data and related tools to perform ETL (Extract, Transform and Load) applications will soon be pervasive in the space sciences. We have entered in a crucial time where using Big Data can be the difference (for terrestrial applications) between organizations underperforming and outperforming their peers. The same is true for NASA and other space agencies, as well as for individual missions and the highly-competitive process of mission data analysis and publication. In most industries, conventional opponents and new candidates alike will influence data-driven approaches to revolutionize and capture the value of Big Data archives. The Open Space Box Model is poised to take the proverbial "giant leap", as it provides autonomic data processing and communications for spacecraft. We can find economic value generated from such use of data processing in our earthly organizations in every sector, such as healthcare, retail. We also can easily find retailers, performing research on Big Data, by utilizing sensors driven embedded data in products within their stores and warehouses to determine how these products are actually used in the real world.

  9. Box –Jenkins Models For Forecasting The Daily Degrees Of Temperature In Sulaimani City.

    Directory of Open Access Journals (Sweden)

    Samira Muhammad Salh

    2014-02-01

    Full Text Available The Auto-regressive model in the time series is regarded one of the statistical articles which is more used because it gives us a simple method to limit the relation between variables time series. More over it is one of Box –Jenkins models to limit the time series in the forecasting the value of phenomenon in the future so that study aims for the practical analysis studying for the auto-regressive models in the time series, through one of Box –Jenkins models for forecasting the daily degrees of temperature in Sulaimani city for the year (2012- Sept.2013 and then for building a sample in the way of special data in the degrees of temperature and its using in the calculating the future forecasting . the style which is used is the descriptive and analyzing by the help of data that is dealt with statistically and which is collected from the official resources To reach his mentioned aim , the discussion of the following items has been done by the theoretical part which includes the idea of time series and its quality and the autocorrelation and Box –Jenkins and then the practical part which includes the statistical analysis for the data and the discussion of the theoretical part, so they reached to a lot of conclusions as it had come in the practical study for building autoregressive models of time series as the mode was very suitable is the auto-regressive model and model moving average by the degree (1,1,1.

  10. Numerical models and experiment of air flow in a simulation box for optical wireless communications

    Science.gov (United States)

    Latal, Jan; Hajek, Lukas; Bojko, Marian; Vitasek, Jan; Koudelka, Petr; Kepak, Stanislav; Vanderka, Ales; Vasinek, Vladimir

    2016-03-01

    In this article, the authors focused on real measurements of mechanical turbulence generated by ventilators in the simulation box for Optical Wireless Communications. The mechanical turbulences disturb the optical beam that propagates along the central axis of the simulation box. The aim of authors is to show the effect of mechanical turbulence on optical beams at different heights in the simulation box. In the Ansys Fluent, we created numerical models which were then compared with real measurements. Authors compared the real and numerical models according to statistical methods.

  11. Numerical models and experiment of air flow in a simulation box for optical wireless communications

    Directory of Open Access Journals (Sweden)

    Latal Jan

    2016-01-01

    Full Text Available In this article, the authors focused on real measurements of mechanical turbulence generated by ventilators in the simulation box for Optical Wireless Communications. The mechanical turbulences disturb the optical beam that propagates along the central axis of the simulation box. The aim of authors is to show the effect of mechanical turbulence on optical beams at different heights in the simulation box. In the Ansys Fluent, we created numerical models which were then compared with real measurements. Authors compared the real and numerical models according to statistical methods.

  12. Integrated Box Interrogation System (IBIS) Preliminary Design Study

    Energy Technology Data Exchange (ETDEWEB)

    DR. Stephen Croft; Mr. David Martancik; Dr. Brian Young; Dr. Patrick MJ Chard; Dr. Robert J Estop; Sheila Melton; Gaetano J. Arnone

    2003-01-13

    Canberra Industries has won the tendered solicitation, INEEL/EST-99-00121 for boxed waste Nondestructive Assay Development and Demonstration. Canberra will provide the Integrated Box Interrogation System (IBIS) which is a suite of assay instrumentation and a data reduction system that addresses the measurement needs for Boxed Wastes identified in the solicitation and facilitates the associated experimental program and demonstration of system capability. The IBIS system will consist of the next generation CWAM system, i.e. CWAM II, which is a Scanning Passive/Active Neutron interrogation system which we will call a Box Segmented Neutron Scanner (BSNS), combined with a physically separate Box Segmented Gamma-ray Scanning (BSGS) system. These systems are based on existing hardware designs but will be tailored to the large sample size and enhanced to allow the program to evaluate the following measurement criteria:Characterization and correction for matrix heterogeneity Characterization of non-uniform radio-nuclide and isotopic compositions Assay of high density matrices (both high-Z and high moderator contents)Correction for radioactive material physical form - such as self shielding or multiplication effects due to large accumulations of radioactive materials.Calibration with a minimal set of reference standards and representative matrices.THis document summarizes the conceptual design parameters of the IBIS and indicates areas key to the success of the project where development is to be centered. The work presented here is a collaborative effort between scientific staff within Canberra and within the NIS-6 group at LANL.

  13. Integrated Box Interrogation System (IBIS) Preliminary Design Study

    International Nuclear Information System (INIS)

    Canberra Industries has won the tendered solicitation, INEEL/EST-99-00121 for boxed waste Nondestructive Assay Development and Demonstration. Canberra will provide the Integrated Box Interrogation System (IBIS) which is a suite of assay instrumentation and a data reduction system that addresses the measurement needs for Boxed Wastes identified in the solicitation and facilitates the associated experimental program and demonstration of system capability. The IBIS system will consist of the next generation CWAM system, i.e. CWAM II, which is a Scanning Passive/Active Neutron interrogation system which we will call a Box Segmented Neutron Scanner (BSNS), combined with a physically separate Box Segmented Gamma-ray Scanning (BSGS) system. These systems are based on existing hardware designs but will be tailored to the large sample size and enhanced to allow the program to evaluate the following measurement criteria:Characterization and correction for matrix heterogeneity Characterization of non-uniform radio-nuclide and isotopic compositions Assay of high density matrices (both high-Z and high moderator contents)Correction for radioactive material physical form - such as self shielding or multiplication effects due to large accumulations of radioactive materials.Calibration with a minimal set of reference standards and representative matrices.THis document summarizes the conceptual design parameters of the IBIS and indicates areas key to the success of the project where development is to be centered. The work presented here is a collaborative effort between scientific staff within Canberra and within the NIS-6 group at LANL

  14. Neural and Neural Gray-Box Modeling for Entry Temperature Prediction in a Hot Strip Mill

    Science.gov (United States)

    Barrios, José Angel; Torres-Alvarado, Miguel; Cavazos, Alberto; Leduc, Luis

    2011-10-01

    In hot strip mills, initial controller set points have to be calculated before the steel bar enters the mill. Calculations rely on the good knowledge of rolling variables. Measurements are available only after the bar has entered the mill, and therefore they have to be estimated. Estimation of process variables, particularly that of temperature, is of crucial importance for the bar front section to fulfill quality requirements, and the same must be performed in the shortest possible time to preserve heat. Currently, temperature estimation is performed by physical modeling; however, it is highly affected by measurement uncertainties, variations in the incoming bar conditions, and final product changes. In order to overcome these problems, artificial intelligence techniques such as artificial neural networks and fuzzy logic have been proposed. In this article, neural network-based systems, including neural-based Gray-Box models, are applied to estimate scale breaker entry temperature, given its importance, and their performance is compared to that of the physical model used in plant. Several neural systems and several neural-based Gray-Box models are designed and tested with real data. Taking advantage of the flexibility of neural networks for input incorporation, several factors which are believed to have influence on the process are also tested. The systems proposed in this study were proven to have better performance indexes and hence better prediction capabilities than the physical models currently used in plant.

  15. Anatomically Detailed and Large-Scale Simulations Studying Synapse Loss and Synchrony Using NeuroBox.

    Science.gov (United States)

    Breit, Markus; Stepniewski, Martin; Grein, Stephan; Gottmann, Pascal; Reinhardt, Lukas; Queisser, Gillian

    2016-01-01

    The morphology of neurons and networks plays an important role in processing electrical and biochemical signals. Based on neuronal reconstructions, which are becoming abundantly available through databases such as NeuroMorpho.org, numerical simulations of Hodgkin-Huxley-type equations, coupled to biochemical models, can be performed in order to systematically investigate the influence of cellular morphology and the connectivity pattern in networks on the underlying function. Development in the area of synthetic neural network generation and morphology reconstruction from microscopy data has brought forth the software tool NeuGen. Coupling this morphology data (either from databases, synthetic, or reconstruction) to the simulation platform UG 4 (which harbors a neuroscientific portfolio) and VRL-Studio, has brought forth the extendible toolbox NeuroBox. NeuroBox allows users to perform numerical simulations on hybrid-dimensional morphology representations. The code basis is designed in a modular way, such that e.g., new channel or synapse types can be added to the library. Workflows can be specified through scripts or through the VRL-Studio graphical workflow representation. Third-party tools, such as ImageJ, can be added to NeuroBox workflows. In this paper, NeuroBox is used to study the electrical and biochemical effects of synapse loss vs. synchrony in neurons, to investigate large morphology data sets within detailed biophysical simulations, and used to demonstrate the capability of utilizing high-performance computing infrastructure for large scale network simulations. Using new synapse distribution methods and Finite Volume based numerical solvers for compartment-type models, our results demonstrate how an increase in synaptic synchronization can compensate synapse loss at the electrical and calcium level, and how detailed neuronal morphology can be integrated in large-scale network simulations. PMID:26903818

  16. Development of an analytical model for predicting the performance behaviour of passive box type catalytic recombiner for H2 mitigation

    International Nuclear Information System (INIS)

    Full text: Among the several methodologies for mitigating the consequences of release of H2 in the containments of NPPs, the one based on passive catalytic recombination with O2 in air is being considered for its application world over. Series of experimental studies for the development of hydrogen mitigation system based on passive box-type catalytic recombiner were conducted in HYMIS test facility at BARC. As a part of back-up to these studies, a computer code BOXCAT for predicting the performance of the convective box type recombiner has been successfully developed at BARC. Some of the salient features of the developed code are : (a) representation of catalytic oxidation reaction by the Arrhenius rate equation. (b) the heat dissipation to the surrounding gas by natural/forced convection and that to the structure by radiation, (c) momentum equation to calculate the buoyancy driven gas flow through the box assuming the entire box as a one-dimensional junction across which the gas mixture accelerates due to net forces acting across the junction and (d) a suitable model to calculate the lumped loss coefficient of the box. The code has been successfully validated against the performance behaviour data of Siemens recombiner for dry conditions as well as against the in-house data generated in HYMIS test facility at BARC. The code is presently capable of handling only dry H2 air mixture (without steam). The validated code has been subsequently used to optimize the design of the new prototype recombiner

  17. Stochastic gradient algorithm for a dual-rate Box-Jenkins model based on auxiliary model and FIR model

    Institute of Scientific and Technical Information of China (English)

    Jing CHEN; Rui-feng DING

    2014-01-01

    Based on the work in Ding and Ding (2008), we develop a modifi ed stochastic gradient (SG) parameter estimation algorithm for a dual-rate Box-Jenkins model by using an auxiliary model. We simplify the complex dual-rate Box-Jenkins model to two fi nite impulse response (FIR) models, present an auxiliary model to estimate the missing outputs and the unknown noise variables, and compute all the unknown parameters of the system with colored noises. Simulation results indicate that the proposed method is effective.

  18. Developing and user-testing Decision boxes to facilitate shared decision making in primary care - a study protocol

    Directory of Open Access Journals (Sweden)

    Rousseau François

    2011-03-01

    Full Text Available Abstract Background Applying evidence is one of the most challenging steps of evidence-based clinical practice. Healthcare professionals have difficulty interpreting evidence and translating it to patients. Decision boxes are summaries of the most important benefits and harms of diagnostic, therapeutic, and preventive health interventions provided to healthcare professionals before they meet the patient. Our hypothesis is that Decision boxes will prepare clinicians to help patients make informed value-based decisions. By acting as primers, the boxes will enhance the application of evidence-based practices and increase shared decision making during the clinical encounter. The objectives of this study are to provide a framework for developing Decision boxes and testing their value to users. Methods/Design We will begin by developing Decision box prototypes for 10 clinical conditions or topics based on a review of the research on risk communication. We will present two prototypes to purposeful samples of 16 family physicians distributed in two focus groups, and 32 patients distributed in four focus groups. We will use the User Experience Model framework to explore users' perceptions of the content and format of each prototype. All discussions will be transcribed, and two researchers will independently perform a hybrid deductive/inductive thematic qualitative analysis of the data. The coding scheme will be developed a priori from the User Experience Model's seven themes (valuable, usable, credible, useful, desirable, accessible and findable, and will include new themes suggested by the data (inductive analysis. Key findings will be triangulated using additional publications on the design of tools to improve risk communication. All 10 Decision boxes will be modified in light of our findings. Discussion This study will produce a robust framework for developing and testing Decision boxes that will serve healthcare professionals and patients alike. It

  19. SimpleBox 4.0: Improving the model while keeping it simple….

    Science.gov (United States)

    Hollander, Anne; Schoorl, Marian; van de Meent, Dik

    2016-04-01

    Chemical behavior in the environment is often modeled with multimedia fate models. SimpleBox is one often-used multimedia fate model, firstly developed in 1986. Since then, two updated versions were published. Based on recent scientific developments and experience with SimpleBox 3.0, a new version of SimpleBox was developed and is made public here: SimpleBox 4.0. In this new model, eight major changes were implemented: removal of the local scale and vegetation compartments, addition of lake compartments and deep ocean compartments (including the thermohaline circulation), implementation of intermittent rain instead of drizzle and of depth dependent soil concentrations, adjustment of the partitioning behavior for organic acids and bases as well as of the value for enthalpy of vaporization. In this paper, the effects of the model changes in SimpleBox 4.0 on the predicted steady-state concentrations of chemical substances were explored for different substance groups (neutral organic substances, acids, bases, metals) in a standard emission scenario. In general, the largest differences between the predicted concentrations in the new and the old model are caused by the implementation of layered ocean compartments. Undesirable high model complexity caused by vegetation compartments and a local scale were removed to enlarge the simplicity and user friendliness of the model. PMID:26802268

  20. Study of plutonium fire extinction in glove-boxes

    International Nuclear Information System (INIS)

    The report concerns attempts to extinguish fire in uranium - chosen as a basis for comparison - and in plutonium, these being contained in glove boxes. The extinguishing powders TEC and MG 10 were tried and compared. The operator used in plastic bags. The metal was dealt with respectively in the form of billets, compact chips and finally thin shavings. In each case fire control was without difficulty. One must allow a certain time for cooling. The powder MG 10 showed very good results. Moreover, the trials proved that densely packed shavings are a very real security factor. The interior lay-out of the glove boxes ought, in order to facilitate further manipulations, be such as to render extinction as easy as possible should the need arise. (authors)

  1. Identification of neomycin B-binding site in T box antiterminator model RNA.

    Science.gov (United States)

    Anupam, Rajaneesh; Denapoli, Leyna; Muchenditsi, Abigael; Hines, Jennifer V

    2008-04-15

    The T box transcription antitermination mechanism regulates the expression of unique genes in many Gram-positive bacteria by responding, in a magnesium-dependent manner, to uncharged cognate tRNA base pairing with an antiterminator RNA element and other regions of the 5'-untranslated region. Model T box antiterminator RNA is known to bind aminoglycosides, ligands that typically bind RNA in divalent metal ion-binding sites. In this study, enzymatic footprinting and spectroscopic assays were used to identify and characterize the binding site of neomycin B to an antiterminator model RNA. Neomycin B binds the antiterminator bulge nucleotides in an electrostatic-dependent manner and displaces 3-4 monovalent cations, indicating that the antiterminator likely contains a divalent metal ion-binding site. Neomycin B facilitates rather than inhibits tRNA binding indicating that bulge-targeted inhibitors that bind the antiterminator via non-electrostatic interactions may be the more optimal candidates for antiterminator-targeted ligand design. PMID:18329274

  2. A simple multistage closed-(box+reservoir model of chemical evolution

    Directory of Open Access Journals (Sweden)

    Caimmi R.

    2011-01-01

    Full Text Available Simple closed-box (CB models of chemical evolution are extended on two respects, namely (i simple closed-(box+reservoir (CBR models allowing gas outflow from the box into the reservoir (Hartwick 1976 or gas inflow into the box from the reservoir (Caimmi 2007 with rate proportional to the star formation rate, and (ii simple multistage closed-(box+reservoir (MCBR models allowing different stages of evolution characterized by different inflow or outflow rates. The theoretical differential oxygen abundance distribution (TDOD predicted by the model maintains close to a continuous broken straight line. An application is made where a fictitious sample is built up from two distinct samples of halo stars and taken as representative of the inner Galactic halo. The related empirical differential oxygen abundance distribution (EDOD is represented, to an acceptable extent, as a continuous broken line for two viable [O/H]-[Fe/H] empirical relations. The slopes and the intercepts of the regression lines are determined, and then used as input parameters to MCBR models. Within the errors (-+σ, regression line slopes correspond to a large inflow during the earlier stage of evolution and to low or moderate outflow during the subsequent stages. A possible inner halo - outer (metal-poor bulge connection is also briefly discussed. Quantitative results cannot be considered for applications to the inner Galactic halo, unless selection effects and disk contamination are removed from halo samples, and discrepancies between different oxygen abundance determination methods are explained.

  3. Delivery of the high-mobility group box 1 box A peptide using heparin in the acute lung injury animal models.

    Science.gov (United States)

    Song, Ji Hyun; Kim, Ji Yeon; Piao, Chunxian; Lee, Seonyeong; Kim, Bora; Song, Su Jeong; Choi, Joon Sig; Lee, Minhyung

    2016-07-28

    In this study, the efficacy of the high-mobility group box-1 box A (HMGB1A)/heparin complex was evaluated for the treatment of acute lung injury (ALI). HMGB1A is an antagonist against wild-type high-mobility group box-1 (wtHMGB1), a pro-inflammatory cytokine that is involved in ALIs. HMGB1A has positive charges and can be captured in the mucus layer after intratracheal administration. To enhance the delivery and therapeutic efficiency of HMGB1A, the HMGB1A/heparin complex was produced using electrostatic interactions, with the expectation that the nano-sized complex with a negative surface charge could efficiently penetrate the mucus layer. Additionally, heparin itself had an anti-inflammatory effect. Complex formation with HMGB1A and heparin was confirmed by atomic force microscopy. The particle size and surface charge of the HMGB1A/heparin complex at a 1:1 weight ratio were 113nm and -25mV, respectively. Intratracheal administration of the complex was performed into an ALI animal model. The results showed that the HMGB1A/heparin complex reduced pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β, more effectively than HMGB1A or heparin alone. Hematoxylin and eosin staining confirmed the decreased inflammatory reaction in the lungs after delivery of the HMGB1A/heparin complex. In conclusion, the HMGB1A/heparin complex might be useful to treat ALI. PMID:27196743

  4. The model of local mode analysis for structural acoustics of box structures

    Science.gov (United States)

    Ngai, King-Wah

    Structure-borne noise is a new noise pollution problem emerging from railway concrete box structures in Hong Kong. Its low frequency noise with intermittent effect can cause considerable nuisance to neighborhoods. The tonal noise peaks in this low frequency range should be one of the important factors in structure-borne noise analysis. In the acoustic field, the deterministic analysis of all the resonant modes of vibration is generally considered as not practical. Many acoustic experts use the statistical energy analysis as the main tool for the noise investigation whereas the application of the experimental modal analysis in the structural acoustic problem is comparatively rare. In the past, most studies mainly focused on the structure-borne noise measurement and analysis. The detail study of the cause of structure-borne noise is lack, especially for the rectangular concrete box structure. In this dissertation, an experimental and analytical approach is adopted to study a typical concrete box model. This thesis aims at confirming the importance of modal analysis in the structure-borne noise study and then at identifying the local vibration modes along the cross-section of box structure. These local modes are responsible for the structure-borne noise radiation. The findings of this study suggest that the web of viaduct cross-section is not as rigid as assumed in the conventional viaduct design and the web face is likely to be more flexible in the vertical displacement of the concrete viaduct. Two types of local vibration modes along the cross-section are identified: the centre mode and the web mode. At the top panel of the viaduct, the centre mode has movement in the middle but not at the edges. The web mode has movement at the edges with the middle fixed. The combined centre and web mode has been found to be important in the structural acoustics of the concrete box structure. In the actual concrete viaduct, the coincidence frequency is especially low (often around

  5. Theoretical Evaluation of the Sediment/Water Exchange Description in Generic Compartment Models (SimpleBox)

    DEFF Research Database (Denmark)

    Sørensen, P. B.; Fauser, P.; Carlsen, L.;

    It is shown how diffusion and deposition of solids drive the flux of substance between the water column and the sediment. The generic compartment models (Mackay type) use a one box model for the sediment in order to keep the calculations simple. However, when diffusion needs to be included in the...

  6. Time-series analysis with a hybrid Box-Jenkins ARIMA and neural network model

    Institute of Scientific and Technical Information of China (English)

    Dilli R Aryal; WANG Yao-wu(王要武)

    2004-01-01

    Time-series analysis is important to a wide range of disciplines transcending both the physical and social sciences for proactive policy decisions. Statistical models have sound theoretical basis and have been successfully used in a number of problem domains in time series forecasting. Due to power and flexibility, Box-Jenkins ARIMA model has gained enormous popularity in many areas and research practice for the last three decades.More recently, the neural networks have been shown to be a promising alternative tool for modeling and forecasting owing to their ability to capture the nonlinearity in the data. However, despite the popularity and the superiority of ARIMA and ANN models, the empirical forecasting performance has been rather mixed so that no single method is best in every situation. In this study, a hybrid ARIMA and neural networks model to time series forecasting is proposed. The basic idea behind the model combination is to use each model's unique features to capture different patterns in the data. With three real data sets, empirical results evidently show that the hybrid model outperforms ARIMA and ANN model noticeably in terms of forecasting accuracy used in isolation.

  7. A box model to estimate collective dose from reprocessing effluent into the Pacific Ocean

    International Nuclear Information System (INIS)

    An adoptable box model system (UMIBOX) has been developed to estimate collective dose from liquid effluent of reprocessing plant at coastal area of the Pacific Ocean. To evaluate the situation of the adjacent seas of Japan, reasonable definition of boxes in the Pacific Ocean is inevitable. Referring to the basis of recent oceanographic knowledge on the circulation of the Pacific water, the boxes have been defined by density structure. The volume, density, salinity, temperature and dissolved oxygen in each box are calculated using all data of the Climatologcal Atlas of the World Ocean by S. Levitus within the 5deg Square for longitudinal and latitudinal directions. Corresponding to the definition of boxes, production data of the marine organisms has been compiled. Preliminary results using the model for the population of Japan and the world are presented. The collective intakes and the collective effective dose equivalent commitments per unit release of various radionuclides into coastal waters are given for a series of integration times. (author)

  8. Geochemical monitoring of volcanic lakes. A generalized box model for active crater lakes

    Directory of Open Access Journals (Sweden)

    Franco Tassi

    2011-06-01

    Full Text Available

    In the past, variations in the chemical contents (SO42−, Cl−, cations of crater lake water have not systematically demonstrated any relationships with eruptive activity. Intensive parameters (i.e., concentrations, temperature, pH, salinity should be converted into extensive parameters (i.e., fluxes, changes with time of mass and solutes, taking into account all the internal and external chemical–physical factors that affect the crater lake system. This study presents a generalized box model approach that can be useful for geochemical monitoring of active crater lakes, as highly dynamic natural systems. The mass budget of a lake is based on observations of physical variations over a certain period of time: lake volume (level, surface area, lake water temperature, meteorological precipitation, air humidity, wind velocity, input of spring water, and overflow of the lake. This first approach leads to quantification of the input and output fluxes that contribute to the actual crater lake volume. Estimating the input flux of the "volcanic" fluid (Qf- kg/s –– an unmeasurable subsurface parameter –– and tracing its variations with time is the major focus during crater lake monitoring. Through expanding the mass budget into an isotope and chemical budget of the lake, the box model helps to qualitatively characterize the fluids involved. The (calculated Cl− content and dD ratio of the rising "volcanic" fluid defines its origin. With reference to continuous monitoring of crater lakes, the present study provides tips that allow better calculation of Qf in the future. At present, this study offers the most comprehensive and up-to-date literature review on active crater lakes.

  9. Manifold boundaries give "gray-box" approximations of complex models

    CERN Document Server

    Transtrum, Mark K

    2016-01-01

    We discuss a method of parameter reduction in complex models known as the Manifold Boundary Approximation Method (MBAM). This approach, based on a geometric interpretation of statistics, maps the model reduction problem to a geometric approximation problem. It operates iteratively, removing one parameter at a time, by approximating a high-dimension, but thin manifold by its boundary. Although the method makes no explicit assumption about the functional form of the model, it does require that the model manifold exhibit a hierarchy of boundaries, i.e., faces, edges, corners, hyper-corners, etc. We empirically show that a variety of model classes have this curious feature, making them amenable to MBAM. These model classes include models composed of elementary functions (e.g., rational functions, exponentials, and partition functions), a variety of dynamical system (e.g., chemical and biochemical kinetics, Linear Time Invariant (LTI) systems, and compartment models), network models (e.g., Bayesian networks, Marko...

  10. Augmented Twin-Nonlinear Two-Box Behavioral Models for Multicarrier LTE Power Amplifiers

    OpenAIRE

    Oualid Hammi

    2014-01-01

    A novel class of behavioral models is proposed for LTE-driven Doherty power amplifiers with strong memory effects. The proposed models, labeled augmented twin-nonlinear two-box models, are built by cascading a highly nonlinear memoryless function with a mildly nonlinear memory polynomial with cross terms. Experimental validation on gallium nitride based Doherty power amplifiers illustrates the accuracy enhancement and complexity reduction achieved by the proposed models. When strong memory ef...

  11. Adaptive MPC based on probabilistic black-box input-output model

    International Nuclear Information System (INIS)

    A novel adaptive model-based predictive-control algorithm is proposed for the control of stable nonlinear dynamic systems. The model of controlled dynamical system is a Gaussian process (GP) model. It is a probabilistic, nonparametric, kernel, black-box model. An evolving GP-modelling method is used for the online model identification. Model-based predictive control utilising such a model results in an adaptive feedback control. The proposed control-method features are illustrated on a simulation example. Key words: evolving Gaussian process model, model-based predictive control, adaptive control

  12. The Analysis of Organizational Diagnosis on Based Six Box Model in Universities

    Science.gov (United States)

    Hamid, Rahimi; Siadat, Sayyed Ali; Reza, Hoveida; Arash, Shahin; Ali, Nasrabadi Hasan; Azizollah, Arbabisarjou

    2011-01-01

    Purpose: The analysis of organizational diagnosis on based six box model at universities. Research method: Research method was descriptive-survey. Statistical population consisted of 1544 faculty members of universities which through random strafed sampling method 218 persons were chosen as the sample. Research Instrument were organizational…

  13. The Particle/Wave-in-a-Box Model in Dutch Secondary Schools

    Science.gov (United States)

    Hoekzema, Dick; van den Berg, Ed; Schooten, Gert; van Dijk, Leo

    2007-01-01

    The combination of mathematical and conceptual difficulties makes teaching quantum physics at secondary schools a precarious undertaking. With many of the conceptual difficulties being unavoidable, simplifying the mathematics becomes top priority. The particle/wave-in-a-box provides a teaching model which includes many aspects of serious …

  14. Estimation parameters and black box model of a brushless DC motor

    Directory of Open Access Journals (Sweden)

    José A. Becerra-Vargas

    2014-08-01

    Full Text Available The modeling of a process or a plant is vital for the design of its control system, since it allows predicting its dynamic and behavior under different circumstances, inputs, disturbances and noise. The main objective of this work is to identify which model is best for a permanent magnet brushless DC specific motor. For this, the mathematical model of a DC motor brushless PW16D, manufactured by Golden Motor, is presented and compared with its black box model; both are derived from experimental data. These data, the average applied voltage and the angular velocity, are acquired by a data acquisition card and imported to the computer. The constants of the mathematical model are estimated by a curve fitting algorithm based on non-linear least squares and pattern search using computational tool. To estimate the mathematical model constants by non-linear least square and search pattern, a goodness of fit of 84.88% and 80.48% respectively was obtained. The goodness of fit obtained by the black box model was 87.72%. The mathematical model presented slightly lower goodness of fit, but allowed to analyze the behavior of variables of interest such as the power consumption and the torque applied to the motor. Because of this, it is concluded that the mathematical model obtained by experimental data of the brushless motor PW16D, is better than its black box model.

  15. Does box model training improve surgical dexterity and economy of movement during virtual reality laparoscopy? A randomised trial

    DEFF Research Database (Denmark)

    Clevin, L.; Grantcharov, T.P.

    2008-01-01

    OBJECTIVE: Laparoscopic box model trainers have been used in training curricula for a long time, however data on their impact on skills acquisition is still limited. Our aim was to validate a low cost box model trainer as a tool for the training of skills relevant to laparoscopic surgery. DESIGN:...

  16. NOx and O3 above a tropical rainforest: an analysis with a global and box model

    Science.gov (United States)

    Pike, R. C.; Lee, J. D.; Young, P. J.; Carver, G. D.; Yang, X.; Warwick, N.; Moller, S.; Misztal, P.; Langford, B.; Stewart, D.; Reeves, C. E.; Hewitt, C. N.; Pyle, J. A.

    2010-11-01

    A cross-platform field campaign, OP3, was conducted in the state of Sabah in Malaysian Borneo between April and July of 2008. Among the suite of observations recorded, the campaign included measurements of NOx and O3 - crucial outputs of any model chemistry mechanism. We describe the measurements of these species made from both the ground site and aircraft. We then use the output from two resolutions of the chemistry transport model p-TOMCAT to illustrate the ability of a global model chemical mechanism to capture the chemistry at the rainforest site. The basic model performance is good for NOx and poor for ozone. A box model containing the same chemical mechanism is used to explore the results of the global model in more depth and make comparisons between the two. Without some parameterization of the nighttime boundary layer - free troposphere mixing (i.e. the use of a dilution parameter), the box model does not reproduce the observations, pointing to the importance of adequately representing physical processes for comparisons with surface measurements. We conclude with a discussion of box model budget calculations of chemical reaction fluxes, deposition and mixing, and compare these results to output from p-TOMCAT. These show the same chemical mechanism behaves similarly in both models, but that emissions and advection play particularly strong roles in influencing the comparison to surface measurements.

  17. Box model and 1D longitudinal model of flow and transport in Bosten Lake, China

    Science.gov (United States)

    Li, Ning; Kinzelbach, Wolfgang; Li, WenPeng; Dong, XinGuang

    2015-05-01

    Bosten Lake in the southeast of Yanqi Catchment, China, supports the downstream agricultural and natural environments. Over the last few decades the intensive agricultural activities in Yanqi Catchment resulted in decreased lake levels and deteriorated lake water quality. A two-box model is constructed to understand the evolution of lake level and salinity between 1958 and 2008. The two-box model of the lake indicates that the evaporation does have the same trend as the observed lake area and the annual average evaporation agrees with the value obtained from the Penman-Monteith approach. To achieve a correct salt balance, the ratio of outflow concentration and average lake concentration has to be around 0.7. This is due to the incomplete mixing of the lake caused by short-circuiting between tributary inflow and the main outflow via the pump stations abstracting water from the lake. This short-circuiting is investigated in more detail by a 1D numerical flow and transport model of the lake calibrated with observations of lake level and lake concentrations. The distributed model reproduces the correct time-varying outflow concentration. It is used for the assessment of two basic management options: increasing river discharge (by water saving irrigation, reduction of phreatic evaporation or reduction of agricultural area) and diverting saline drainage water to the desert. Increasing river discharge to the lake by 20% reduces the east basin salt concentration by 0.55 kg/m3, while capturing all the drainage water and discharging it to depressions instead of the lake reduces the east basin salt concentration by 0.63 kg/m3. A combination of increasing river inflow and decreasing drainage salt flux is sufficient to bring future lake TDS below the required 1 kg/m3, to keep a lake level that sustains the lake ecosystem, and to supply more water for downstream development and ecosystem rehabilitation.

  18. A Grey-Box Model for Spray Drying Plants

    DEFF Research Database (Denmark)

    Petersen, Lars Norbert; Poulsen, Niels Kjølstad; Niemann, Hans Henrik;

    2013-01-01

    Multi-stage spray drying is an important and widely used unit operation in the production of food powders. In this paper we develop and present a dynamic model of the complete drying process in a multi-stage spray dryer. The dryer is divided into three stages: The spray stage and two fluid bed...

  19. Optimal experiment design for identification of grey-box models

    OpenAIRE

    Sadegh, Payman; Melgaard, Henrik; Madsen, Henrik; Holst, Jan

    1994-01-01

    Optimal experiment design is investigated for stochastic dynamic systems where the prior partial information about the system is given as a probability distribution function in the system parameters. The concept of information is related to entropy reduction in the system through Lindley's measure of average information, and the relationship between the choice of information related criteria and some estimators (MAP and MLE) is established. A continuous time physical model of the heat dynamic...

  20. Optimal experiment design for identification of grey-box models

    DEFF Research Database (Denmark)

    Sadegh, Payman; Melgaard, Henrik; Madsen, Henrik; Holst, Jan

    Optimal experiment design is investigated for stochastic dynamic systems where the prior partial information about the system is given as a probability distribution function in the system parameters. The concept of information is related to entropy reduction in the system through Lindley's measure...... to a MAP estimation results in a considerable reduction of the experimental length. Besides, it is established that the physical knowledge of the system enables us to design experiments, with the goal of maximizing information about the physical parameters of interest....... of average information, and the relationship between the choice of information related criteria and some estimators (MAP and MLE) is established. A continuous time physical model of the heat dynamics of a building is considered and the results show that performing an optimal experiment corresponding...

  1. A Two-Step Identification Approach for Twin-Box Models of RF Power Amplifier

    Directory of Open Access Journals (Sweden)

    You-Jiang Liu

    2011-01-01

    Full Text Available We propose a two-step identification approach for twin-box model (Wiener or Hammerstein of RF power amplifier. The linear filter block and the static nonlinearity block are extracted, respectively, based on least-squares method, by iterative calculation. Simulations show that the method can get quite accurate parameters to model different nonlinear models with memory such as Wiener, Hammerstein, Wiener-Hammerstein (W-H, and memory polynomial models, hence, demonstrating its robustness. Furthermore, experimental results show excellent agreement between measured output and modeled output, where one carrier WCDMA signal is used as the excitation for a wideband RF amplifier.

  2. Quantifying atmospheric transport, chemistry, and mixing using a new trajectory-box model and a global atmospheric-chemistry GCM

    OpenAIRE

    H. Riede; Jöckel, P.; Sander, R.

    2009-01-01

    We present a novel method for the quantification of transport, chemistry, and mixing along atmospheric trajectories based on a consistent model hierarchy. The hierarchy consists of the new atmospheric-chemistry trajectory-box model CAABA/MJT and the three-dimensional (3-D) global ECHAM/MESSy atmospheric-chemistry (EMAC) general circulation model. CAABA/MJT employs the atmospheric box model CAABA in a configuration using the atmospheric-chemistry submodel MECCA (M), the photochemistry submodel...

  3. Prediction of PM 10 concentrations at urban traffic intersections using semi-empirical box modelling with instantaneous velocity and acceleration

    Science.gov (United States)

    He, Hong-di; Lu, Wei-Zhen; Xue, Yu

    2009-12-01

    At urban traffic intersections, vehicles frequently stop with idling engines during the red-light period and speed up rapidly during the green-light period. The changes of driving patterns (i.e., idle, acceleration, deceleration and cruising patterns) generally produce uncertain emission. Additionally, the movement of pedestrians and the influence of wind further result in the random dispersion of pollutants. It is, therefore, too complex to simulate the effects of such dynamics on the resulting emission using conventional deterministic causal models. For this reason, a modified semi-empirical box model for predicting the PM 10 concentrations on roadsides is proposed in this paper. The model constitutes three parts, i.e., traffic, emission and dispersion components. The traffic component is developed using a generalized force traffic model to obtain the instantaneous velocity and acceleration when vehicles move through intersections. Hence the distribution of vehicle emission in street canyon during the green-light period is calculated. Then the dispersion component is investigated using a semi-empirical box model combining average wind speed, box height and background concentrations. With these considerations, the proposed model is applied and evaluated using measured data at a busy traffic intersection in Mong Kok, Hong Kong. In order to test the performance of the model, two situations, i.e., the data sets within a sunny day and between two sunny days, were selected to examine the model performance. The predicted values are generally well coincident with the observed data during different time slots except several values are overestimated or underestimated. Moreover, two types of vehicles, i.e., buses and petrol cars, are separately taken into account in the study. Buses are verified to contribute most to the emission in street canyons, which may be useful in evaluating the impact of vehicle emissions on the ambient air quality when there is a significant change

  4. Trajectory Optimization under Changing Conditions through Evolutionary Approach and Black-Box Models with Refining

    Czech Academy of Sciences Publication Activity Database

    Macek, Karel; Rojíček, J.; Bičík, V.

    Vol. XVIII. Cham: Springer, 2013, s. 267-274. (XVIII. 217). ISBN 978-3-319-00550-8. [10th International Symposium on Distributed Computing and Artificial Intelligence . Salamanca (ES), 22.05.2013-24.05.2013] Institutional support: RVO:67985556 Keywords : Empirical function minimization * black-box modeling * simplification * refining * dynamic building control Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2013/AS/macek-trajectory optimization under changing.pdf

  5. Comparative uncertainty analysis of copper loads in stormwater systems using GLUE and grey-box modeling

    DEFF Research Database (Denmark)

    Lindblom, Erik Ulfson; Madsen, Henrik; Mikkelsen, Peter Steen

    2007-01-01

    In this paper two attempts to assess the uncertainty involved with model predictions of copper loads from stormwater systems are made. In the first attempt, the GLUE methodology is applied to derive model parameter sets that result in model outputs encompassing a significant number of the...... proposed model and input data, the GLUE analysis show that the total sampled copper mass can be predicted within a range of +/- 50% of the median value ( 385 g), whereas the grey-box analysis showed a prediction uncertainty of less than +/- 30%. Future work will clarify the pros and cons of the two methods...

  6. Estimation parameters and black box model of a brushless DC motor

    OpenAIRE

    José A. Becerra-Vargas; Francisco E. Moreno-García; Juan J. Quiroz-Omaña; Deyanira Bautista-Arias

    2014-01-01

    The modeling of a process or a plant is vital for the design of its control system, since it allows predicting its dynamic and behavior under different circumstances, inputs, disturbances and noise. The main objective of this work is to identify which model is best for a permanent magnet brushless DC specific motor. For this, the mathematical model of a DC motor brushless PW16D, manufactured by Golden Motor, is presented and compared with its black box model; both are derived from experimenta...

  7. Finite element model updating of a prestressed concrete box girder bridge using subproblem approximation

    Science.gov (United States)

    Chen, G. W.; Omenzetter, P.

    2016-04-01

    This paper presents the implementation of an updating procedure for the finite element model (FEM) of a prestressed concrete continuous box-girder highway off-ramp bridge. Ambient vibration testing was conducted to excite the bridge, assisted by linear chirp sweepings induced by two small electrodynamic shakes deployed to enhance the excitation levels, since the bridge was closed to traffic. The data-driven stochastic subspace identification method was executed to recover the modal properties from measurement data. An initial FEM was developed and correlation between the experimental modal results and their analytical counterparts was studied. Modelling of the pier and abutment bearings was carefully adjusted to reflect the real operational conditions of the bridge. The subproblem approximation method was subsequently utilized to automatically update the FEM. For this purpose, the influences of bearing stiffness, and mass density and Young's modulus of materials were examined as uncertain parameters using sensitivity analysis. The updating objective function was defined based on a summation of squared values of relative errors of natural frequencies between the FEM and experimentation. All the identified modes were used as the target responses with the purpose of putting more constrains for the optimization process and decreasing the number of potentially feasible combinations for parameter changes. The updated FEM of the bridge was able to produce sufficient improvements in natural frequencies in most modes of interest, and can serve for a more precise dynamic response prediction or future investigation of the bridge health.

  8. A diary study to open up the black box of overtime work among university faculty members

    NARCIS (Netherlands)

    Beckers, D.G.J.; Hooff, M.L.M. van; Linden, D. van der; Kompier, M.A.J.; Taris, T.W.; Geurts, S.A.E.

    2008-01-01

    Objectives: This study aimed at opening up the black box of overtime work among university faculty members by providing information on (i) when faculty members work overtime, (ii) what activities are undertaken during overtime, and (iii) how overtime is experienced. Methods: Data were collected amon

  9. In silico studies on structure-function of DNA GCC- box binding domain of brassica napus DREB1 protein

    International Nuclear Information System (INIS)

    DREB1 is a transcriptional factor, which selectively binds with the promoters of the genes involved in stress response in the plants. Homology of DREB protein and its binding element have been detected in the genome of many plants. However, only a few reports exist that discusses the binding properties of this protein with the gene (s) promoter. In the present study, we have undertaken studies exploring the structure-function relationship of Brassica napus DREB1. Multiple sequence alignment, protein homology modeling and intermolecular docking of GCC-box binding domain (GBD) of the said protein was carried out using atomic coordinates of GBD from Arabdiopsis thaliana and GCC-box containing DNA respectively. Similarities and/or identities in multiple, sequence alignment, particularly at the functionally important amino acids, strongly suggested the binding specificity of B. napus DREB1 to GCC-box. Similarly, despite 56% sequence homology, tertiary structures of both template and modeled protein were found to be extremely similar as indicated by root mean square deviation of 0.34 A. More similarities were established between GBD of both A. thaliana and B. napus DREB1 by conducting protein docking with the DNA containing GCC-box. It appears that both proteins interact through their beta-sheet with the major DNA groove including both nitrogen bases and phosphate and sugar moieties. Additionally, in most cases the interacting residues were also found to be identical. Briefly, this study attempts to elucidate the molecular basis of DREB1 interaction with its target sequence in the promoter. (author)

  10. Grey-box Modeling for System Identification of Household Refrigerators: a Step Toward Smart Appliances

    DEFF Research Database (Denmark)

    Costanzo, Giuseppe Tommaso; Sossan, Fabrizio; Marinelli, Mattia;

    2013-01-01

    This paper presents the grey-box modeling of a vapor-compression refrigeration system for residential applications based on maximum likelihood estimation of parameters in stochastic differential equations. Models obtained are useful in the view of controlling refrigerators as flexible consumption...... units, which operation can be shifted within temperature and operational constraints. Even if the refrigerators are not intended to be used as smart loads, validated models are useful in predicting units consumption. This information can increase the optimality of the management of other flexible units...

  11. Effect of image capture device on the accuracy of black-box printer models

    Science.gov (United States)

    Youn, Jason; Sun, Jian; Ju, Yanling; Kashti, Tamar; Frank, Tal; Kella, Dror; Fischer, Mani; Ulichney, Robert; Adams, Guy; Allebach, Jan

    2014-01-01

    In the process of electrophotograpic (EP) printing, the deposition of toner to the printer-addressable pixel is greatly influenced by the neighboring pixels of the digital halftone. To account for these effects, printer models can either be embedded in the halftoning algorithm, or used to predict the printed halftone image at the input to an algorithm that is used to assess print quality. Most recently,1 we developed a series of six new models to accurately account for local neighborhood effects and the influence of a 45 x 45 neighborhood of pixels on the central printer-addressable pixel. We refer to all these models as black-box models, since they are based solely on measuring what is on the printed page, and do not incorporate any information about the marking process itself. In this paper, we will compare black-box models developed with three different capture devices: an Epson Expression 10000XL (Epson America, Inc., Long Beach, CA, USA) flatbed scanner operated at 2400 dpi with an active field of view of 309.88 mm x 436.88 mm, a QEA PIAS-II (QEA, Inc., Billerica, MA, USA) camera with resolution 7663.4 dpi and a field of view of 2.4 mm x 3.2 mm, and Dr. CID, a 1:1 magnification 3.35 micron true resolution Dyson Relay lens-based 3 Mpixel USB CMOS imaging device2 with resolution 7946.8 dpi and a field of view of 4.91 mm 6.55 mm developed at Hewlett-Packard Laboratories { Bristol. Our target printer is an HP Indigo 5000 Digital Press (HP Indigo, Ness Ziona, Israel). In this paper, we will compare the accuracy of the black-box model predictions of print microstructure using models trained from images captured with these three devices.

  12. Modeling and new equipment definition for the vibration isolation box equipment system

    Science.gov (United States)

    Sani, Robert L.

    1993-01-01

    Our MSAD-funded research project is to provide numerical modeling support for the VIBES (Vibration Isolation Box Experiment System) which is an IML2 flight experiment being built by the Japanese research team of Dr. H. Azuma of the Japanese National Aerospace Laboratory. During this reporting period, the following have been accomplished: A semi-consistent mass finite element projection algorithm for 2D and 3D Boussinesq flows has been implemented on Sun, HP And Cray Platforms. The algorithm has better phase speed accuracy than similar finite difference or lumped mass finite element algorithms, an attribute which is essential for addressing realistic g-jitter effects as well as convectively-dominated transient systems. The projection algorithm has been benchmarked against solutions generated via the commercial code FIDAP. The algorithm appears to be accurate as well as computationally efficient. Optimization and potential parallelization studies are underway. Our implementation to date has focused on execution of the basic algorithm with at most a concern for vectorization. The initial time-varying gravity Boussinesq flow simulation is being set up. The mesh is being designed and the input file is being generated. Some preliminary 'small mesh' cases will be attempted on our HP9000/735 while our request to MSAD for supercomputing resources is being addressed. The Japanese research team for VIBES was visited, the current set up and status of the physical experiment was obtained and ongoing E-Mail communication link was established.

  13. Improved concept models for straight thin-walled columns with box cross section

    Institute of Scientific and Technical Information of China (English)

    Yu-cheng LIU

    2008-01-01

    This paper focuses on developing improved concept models for straight thin-walled box sectional columns which can better predict the peak crushing force that occurs during crashworthiness analyses.We develop a nonlinear translational spring based on previous research and apply such a spring element to build the enhanced concept models.The work presented in this article is developed on the basis of the publication of the author(Liu and Day,2006b)and has been applied in a crashworthiness design issue,which is presented by the author in another paper(Liu,2008).

  14. Effect of Interfacial Debonding on the Strength of Composite Structure-Similarity Scale Model for the Wing-Box

    OpenAIRE

    Shiyong Sun; Rui Yang; Zibin Yan; Wei Qian

    2015-01-01

    Based on the wing-box structure, a model was established to analyze the strength of the scale model for the composite wing. Firstly, different failure criteria were set to determine damage onset of the components. The continuum damage variables were adopted in the stiffness degradation rule. Secondly, the interface elements were placed along the interface between the beam flange and the skin to investigate the effects of bonding strength on the ultimate load-carrying capacity of the wing-box....

  15. A multi-variable box model approach to the soft tissue carbon pump

    Directory of Open Access Journals (Sweden)

    A. M. de Boer

    2010-12-01

    Full Text Available The canonical question of which physical, chemical or biological mechanisms were responsible for oceanic uptake of atmospheric CO2 during the last glacial is yet unanswered. Insight from paleo-proxies has led to a multitude of hypotheses but none so far have been convincingly supported in three dimensional numerical modelling experiments. The processes that influence the CO2 uptake and export production are inter-related and too complex to solve conceptually while complex numerical models are time consuming and expensive to run which severely limits the combinations of mechanisms that can be explored. Instead, an intermediate inverse box model approach of the soft tissue pump is used here in which the whole parameter space is explored. The glacial circulation and biological production states are derived from these using proxies of glacial export production and the need to draw down CO2 into the ocean. We find that circulation patterns which explain glacial observations include reduced Antarctic Bottom Water formation and high latitude upwelling and mixing of deep water and to a lesser extent reduced equatorial upwelling. The proposed mechanism of CO2 uptake by an increase of eddies in the Southern Ocean, leading to a reduced residual circulation, is not supported. Regarding biological mechanisms, an increase in the nutrient utilization in either the equatorial regions or the northern polar latitudes can reduce atmospheric CO2 and satisfy proxies of glacial export production. Consistent with previous studies, CO2 is drawn down more easily through increased productivity in the Antarctic region than the sub-Antarctic, but that violates observations of lower export production there. The glacial states are more sensitive to changes in the circulation and less sensitive to changes in nutrient utilization rates than the interglacial states.

  16. Finite element cochlea box model - Mechanical and electrical analysis of the cochlea

    Science.gov (United States)

    Nikolic, Milica; Teal, Paul D.; Isailovic, Velibor; Filipović, Nenad

    2015-12-01

    The primary role of the cochlea is to transform external sound stimuli into mechanical vibrations and then to neural impulses which are sent to the brain. A simplified cochlea box model was developed using the finite element method. Firstly, a mechanical model of the cochlea was analyzed. The box model consists of the basilar membrane and two fluid chambers - the scala vestibuli and scala tympani. The third chamber, the scala media, was neglected in the mechanical analysis. The best agreement with currently available analytical and experimental results was obtained when behavior of the fluid in the chambers was described using the wave acoustic equation and behavior of the basilar membrane was modeled with Newtonian dynamics. The obtained results show good frequency mapping. The second approach was to use an active model of the cochlea in which the Organ of Corti was included. The operation of the Organ of Corti involves the generation of current, caused by mechanical vibration. This current in turn causes a force applied to the basilar membrane, creating in this way an active feedback mechanism. A state space representation of the electro-mechanical model from existing literature was implemented and a first comparison with the finite element method is presented.

  17. Exciton and biexciton binding and vertical Stark effect in a model lens-shaped quantum box: Application to InAs/InP quantum dots

    International Nuclear Information System (INIS)

    The problem of excitonic and biexcitonic binding is studied in the system of parabolic coordinates for a lens-shaped quantum box. The exciton wavefunction is expanded in terms of electron-hole configurations made from electron and hole single-particle states. Configuration interaction method and perturbative calculations are used to study the competition between confinement and correlation effects. Biexcitonic binding energy is calculated in the strong confinement regime and a comparison to the case of a spherical box is made. Absorption spectra with and without correlation effects are computed for InAs/InP quantum dots. Excitonic binding energy and enhancement factor are estimated to be equal to about 20 meV and 1.5, respectively. The excitonic absorption is finally studied in the presence of a uniform vertical electric field. A weak vertical Stark effect is predicted for lens-shaped quantum box described within this model

  18. Exciton and biexciton binding and vertical Stark effect in a model lens-shaped quantum box: Application to InAs/InP quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Cornet, C. [FOTON-UMR 6082 au CNRS, INSA de Rennes, 20 Avenue des Buttes de Coesmes, CS 14315, F-34043 Rennes Cedex (France)]. E-mail: charles.cornet@ens.insa-rennes.fr; Even, J. [FOTON-UMR 6082 au CNRS, INSA de Rennes, 20 Avenue des Buttes de Coesmes, CS 14315, F-34043 Rennes Cedex (France)]. E-mail: jacky.even@insa-rennes.fr; Loualiche, S. [FOTON-UMR 6082 au CNRS, INSA de Rennes, 20 Avenue des Buttes de Coesmes, CS 14315, F-34043 Rennes Cedex (France)

    2005-09-19

    The problem of excitonic and biexcitonic binding is studied in the system of parabolic coordinates for a lens-shaped quantum box. The exciton wavefunction is expanded in terms of electron-hole configurations made from electron and hole single-particle states. Configuration interaction method and perturbative calculations are used to study the competition between confinement and correlation effects. Biexcitonic binding energy is calculated in the strong confinement regime and a comparison to the case of a spherical box is made. Absorption spectra with and without correlation effects are computed for InAs/InP quantum dots. Excitonic binding energy and enhancement factor are estimated to be equal to about 20 meV and 1.5, respectively. The excitonic absorption is finally studied in the presence of a uniform vertical electric field. A weak vertical Stark effect is predicted for lens-shaped quantum box described within this model.

  19. Gray-box modeling and validation of residential HVAC system for control system design

    International Nuclear Information System (INIS)

    Highlights: • Gray-box models of residential HVAC system are developed. • Measurements were made on the inputs and outputs of each subsystem. • The parameters of the models were found by nonlinear least squares optimization. • Models were simulated in Matlab Simulink® and compared with the measurements. • Integrated HVAC model was developed by cascading the individual subsystem models. - Abstract: In this paper gray-box models of the residential heating, ventilation and air conditioning (HVAC) system were developed. The HVAC system comprises of several subsystems such as energy recovery ventilator (ERV), air handling unit (AHU), buffer tank (BT), radiant floor heating (RFH) system, zone and ground source heat pump (GSHP) whose models can be identified separately and combined to obtain the model of the full system. The parameters of the subsystem models were identified from the data measured from the instrumented TRCA Archetype Sustainable House (TRCA-ASH) HVAC systems located at Kortright Centre for Conservation in Vaughan, Ontario, Canada. Individual subsystem models were combined to obtain the full system model which replicates the performance of the existing HVAC system and provides the cost estimate for running the HVAC system. Existing HVAC system uses ON/OFF controllers for zone temperature and BT temperature control. The ON/OFF controllers were integrated into the full scale system model and energy estimates were calculated for the operation of primary and secondary components (e.g., GSHP, fans and pumps). This model can be used to further investigate the effects of more advanced controllers (e.g., PID, model predictive control-MPC) and energy conservation strategies (e.g., set-point reset, passive/active thermal energy storage) in the simulation before implementing on the existing HVAC system

  20. A Novel Approach for Pass Word Authentication using Brain -State -In -A Box (BSB) Model

    CERN Document Server

    Chakravarthy, A S N; Avadhani, P S

    2011-01-01

    Authentication is the act of confirming the truth of an attribute of a datum or entity. This might involve confirming the identity of a person, tracing the origins of an artefact, ensuring that a product is what it's packaging and labelling claims to be, or assuring that a computer program is a trusted one. The authentication of information can pose special problems (especially man-in-the-middle attacks), and is often wrapped up with authenticating identity. Password authentication using Brain-State -In-A Box is presented in this paper. Here in this paper we discuss Brain-State -In-A Box Scheme for Textual and graphical passwords which will be converted in to probabilistic values Password. We observe how to get password authentication Probabilistic values for Text and Graphical image. This study proposes the use of a Brain-State -In-A Box technique for password authentication. In comparison to existing layered neural network techniques, the proposed method provides better accuracy and quicker response time to...

  1. Form optimization thermomechanical studies on FBR steam generator steam box made of steel 2 1/4 Cr 1 Mo

    International Nuclear Information System (INIS)

    In breeder power stations the steam generator produces steam at a high temperature and pressure (4950C and 195 bar). Because of the mediocre mechanical characteristics of steel containing 2 1/4 Cr 1 Mo at high temperatures, the use of such a steel for steam generator steam boxes in this reactor system involves a compromise between: - the advantage of large thicknesses, which allow a reduction of the high stresses due to elevated operating pressures, - the rapid penalization on the thermal stresses which results from increasing the thicknesses. The main loads to which the steam outlet box is subjected in modular steam generators of Stein Industrie design are presented, and the steps leading to a satisfactory definition of the structure are explained. It is shown how the choice of rules of the ASME coce N47 leads to the definition of simple stress limiting criteria using Elastic Analysis. Some indications are given on the stresses and principles which motivated the choice of the general form of the structure, and an explanation is given of the simplified method of studying the effect of the head thickness which lay behind the design orientation. Finally, it is shown how the choice of the final design of the steam box was able to be made only after investigation of the best forms by two-dimensional thermomechanical modelling by the finite element method. (orig.)

  2. Bolt study - behaviour of bolts in drop accident scenarios of the Nirex 3m3 Box ILW package

    International Nuclear Information System (INIS)

    The mission of Nirex is to provide the UK with safe, environmentally sound and publicly acceptable options for the long-term management of radioactive materials. One of the key tasks is to ensure that waste is packaged by waste producers in a form which is suitable for safe storage, transport, handling and potential disposal. In pursuit of this key requirement, Nirex has developed specifications to set the standard for the design and performance of waste packages, and has developed standard containers for the packaging of intermediate level (ILW) and some low level waste (LLW) - one of these is the 3m3 Box for immobilised operational and decommissioning ILW. The dimension envelope of this package is 1716 mm x 1716 mm in plan with 430 mm corner radii, 1226 mm tall. The maximum loaded weight is 12 tonnes. A generic design of this container has been developed, which is a welded structure manufactured from austenitic stainless steel (EN 10088-2 steel number 1.4404). The lid is connected to the body by 28 stainless steel bolts. An extensive study was carried out to develop a robust FE model of the bolts. The specific focus of this work was to use improved bolt modelling to optimize the design of the 3m3 Box, although this work could be applied to other bolted containers. This paper presents a summary of the findings from the study as follows: 1. Development of a FE bolt model for application in a 3m3 Box model. 2. Development and execution of a bolt testing programme which included tensile and shear tests on a total of 88 bolts, representing four grades of stainless steel materials, three thread sizes, and two geometries at three strain rates. 3. Benchmarking of the FE bolt model that can be used with confidence in simulating waste package behaviour in drop scenarios

  3. Bolt study - behaviour of bolts in drop accident scenarios of the Nirex 3m{sup 3} Box ILW package

    Energy Technology Data Exchange (ETDEWEB)

    Turner, G. [United Kingdom Nirex Ltd., Harwell (United Kingdom); Tso, C.F. [Arup, London (United Kingdom)

    2004-07-01

    The mission of Nirex is to provide the UK with safe, environmentally sound and publicly acceptable options for the long-term management of radioactive materials. One of the key tasks is to ensure that waste is packaged by waste producers in a form which is suitable for safe storage, transport, handling and potential disposal. In pursuit of this key requirement, Nirex has developed specifications to set the standard for the design and performance of waste packages, and has developed standard containers for the packaging of intermediate level (ILW) and some low level waste (LLW) - one of these is the 3m{sup 3} Box for immobilised operational and decommissioning ILW. The dimension envelope of this package is 1716 mm x 1716 mm in plan with 430 mm corner radii, 1226 mm tall. The maximum loaded weight is 12 tonnes. A generic design of this container has been developed, which is a welded structure manufactured from austenitic stainless steel (EN 10088-2 steel number 1.4404). The lid is connected to the body by 28 stainless steel bolts. An extensive study was carried out to develop a robust FE model of the bolts. The specific focus of this work was to use improved bolt modelling to optimize the design of the 3m{sup 3} Box, although this work could be applied to other bolted containers. This paper presents a summary of the findings from the study as follows: 1. Development of a FE bolt model for application in a 3m{sup 3} Box model. 2. Development and execution of a bolt testing programme which included tensile and shear tests on a total of 88 bolts, representing four grades of stainless steel materials, three thread sizes, and two geometries at three strain rates. 3. Benchmarking of the FE bolt model that can be used with confidence in simulating waste package behaviour in drop scenarios.

  4. The ionospheric source of magnetospheric plasma is not a black box input for global models

    Science.gov (United States)

    Welling, D. T.; Liemohn, M. W.

    2016-06-01

    Including ionospheric outflow in global magnetohydrodynamic models of near-Earth outer space has become an important step toward understanding the role of this plasma source in the magnetosphere. Of the existing approaches, however, few tie the outflowing particle fluxes to magnetospheric conditions in a self-consistent manner. Doing so opens the magnetosphere-ionosphere system to nonlinear mass-energy feedback loops, profoundly changing the behavior of the magnetosphere-ionosphere system. Based on these new results, it is time for the community eschew treating ionospheric outflow as a simple black box source of magnetospheric plasma.

  5. Investigation of Gaussian Processes and Random Forests as Surrogate Models for Evolutionary Black-Box Optimization

    Czech Academy of Sciences Publication Activity Database

    Bajer, Lukáš; Pitra, Z.; Holeňa, Martin

    New York: ACM, 2015 - (Silva, S.), s. 1351-1352 ISBN 978-1-4503-3488-4. [GECCO Companion '15. Genetic and Evolutionary Computation Conference. Madrid (ES), 11.07.2015-15.07.2015] R&D Projects: GA ČR GA13-17187S Grant ostatní: ČVUT(CZ) SGS14/205/OHK4/3T/14; GA MŠk(CZ) ED2.1.00/03.0078 Institutional support: RVO:67985807 Keywords : Black-box optimization * Surrogate model * Gaussian process * Random forest Subject RIV: IN - Informatics, Computer Science

  6. Model guided sampling optimization with gaussian processes for expensive black-box optimization

    Czech Academy of Sciences Publication Activity Database

    Bajer, Lukáš; Charypar, V.; Holeňa, Martin

    New York : ACM, 2013 - (Blum, C.), s. 1715-1716 ISBN 978-1-4503-1964-5. [GECCO 2013. Genetic and Evolutionary Computation Conference. Amsterdam (NL), 06.07.2013-10.07.2013] R&D Projects: GA ČR GAP202/11/1368; GA ČR GA13-17187S Grant ostatní: GA UK(CZ) 278511/2011; CTU(CZ) SGS12/196/OHK3/3T/14 Institutional support: RVO:67985807 Keywords : benchmarking * black-box optimization * modelling * gaussian processes Subject RIV: IN - Informatics, Computer Science

  7. Cyclin-like F-box protein plays a role in growth and development of the three model species Medicago truncatula, Lotus japonicus, and Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Boycheva I

    2015-08-01

    Full Text Available Irina Boycheva,1 Valya Vassileva,2 Miglena Revalska,1 Grigor Zehirov,2 Anelia Iantcheva1 1Department of Functional Genetics Legumes, 2AgroBioInstitute, Department of Plant Stress Molecular Biology, Institute of Plant Physiology and Genetics, Sofia, Bulgaria Abstract: In eukaryotes, F-box proteins are one of the main components of the SCF complex that belongs to the family of ubiquitin E3 ligases, which catalyze protein ubiquitination and maintain the balance between protein synthesis and degradation. In the present study, we clarified the role and function of the gene encoding cyclin-like F-box protein from Medicago truncatula using transgenic plants of the model species M. truncatula, Lotus japonicas, and Arabidopsis thaliana generated by Agrobacterium-mediated transformation. Morphological and transcriptional analyses combined with flow cytometry and histochemistry demonstrated the participation of this protein in many aspects of plant growth and development, including processes of indirect somatic embryogenesis and symbiotic nodulation. The cyclin-like F-box gene showed expression in all plant organs and tissues comprised of actively dividing cells. The observed variations in root and hypocotyl growth, leaf and silique development, ploidy levels, and leaf parameters in the obtained transgenic lines demonstrated the effects of this gene on organ development. Furthermore, knockdown of cyclin-like F-box led to accumulation of higher levels of the G2/M transition-specific gene cyclin B1:1 (CYCB1:1, suggesting its possible role in cell cycle control. Together, the collected data suggest a similar role of the cyclin-like F-box protein in the three model species, providing evidence for the functional conservation of the studied gene. Keywords: cyclin-like F-box, model legumes, Arabidopsis thaliana, plant growth, plant development, cell cycle

  8. The occupation of a box as a toy model for the seismic cycle of a fault

    CERN Document Server

    González, A; Pacheco, A F; Gonzalez, Alvaro; Gomez, Javier B.; Pacheco, Amalio F.

    2005-01-01

    In this paper we illustrate that simple statistical models can describe the quasi periodic occurrence of earthquakes in a seismic fault. With this aim, we idealize the loading of elastic energy in a fault with the stochastic filling of a box. The emptying of the box after its complete filling is analogous to the generation of a large earthquake, in which the fault relaxes after having been loaded to its failure threshold. The duration of that filling process is thus equivalent to the seismic cycle in the fault, i.e. the period elapsed between two successive large earthquakes in that fault. The simplicity of this model enables us to characterize the statistical distribution of the duration of its seismic cycle, its mean, standard deviation and aperiodicity. In order to compare the results with actual data, we use this distribution as a renewal model to fit the series of characteristic earthquakes, with magnitude around 6, which occurred at the Parkfield segment of the San Andreas fault in California. After ass...

  9. A study of lifting scheme and Box Jenkins approach for short term load forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Lin, W.B. [Far East Univ., Tainan, Taiwan (China). Dept. of Electrical Engineering; Lee, C.M. [Nan Kai Inst. of Technology, Nantou, Taiwan (China). Dept. of Computer and Communication Engineering; Shih, K.R. [National Formosa Univ., Yunlin, Taiwan (China). Dept. of Electrical Engineering; Huang, C.H. [National Yunlin Univ. of Science and Technology, Yunlin, Taiwan (China). Graduate School of Engineering Science and Technology

    2008-07-01

    This paper presented a new approach for short term load forecasting that combined the lifting scheme and Box Jenkins technique. The lifting scheme based on multi-revolution analysis (MRA) was used to extract the features and characteristics of load data which stand for low frequency and high frequency components. The lifting scheme is a general and flexible method for the construction of bi-orthogonal wavelets entirely in the spatial domain. It has many advantages over the classical wavelet transform, including fast calculation and in-place implementation of the wavelet transform. As such, forecasting accuracy improved. Based on wavelet MRA, the original load series was decomposed through the lifting scheme into different sub-series at different levels of revolution, which showed the different frequency characteristic of the load. The sub-series was then forecasted by the Box Jenkins seasonal autoregressive integrated moving average model (SARIMA). The proposed method was tested in the hourly load forecast provided by the Taipower Company. A comparison of the proposed method with the Box Jenkins method demonstrated that the proposed method is accurate for short term load forecasting. 21 refs., 3 tabs., 9 figs.

  10. Electroweak ZZjj production in the Standard Model and beyond in the POWHEG-BOX V2

    International Nuclear Information System (INIS)

    We present an implementation of electroweak ZZjj production in the POWHEG BOX V2 framework, an upgrade of the POWHEG BOX program which includes a number of new features that are particularly helpful for high-multiplicity processes. We consider leptonic and semi-leptonic decay modes of the Z bosons, and take non-resonant contributions and spin correlations of the final-state particles into account. In the case of decays to leptons, we also include interactions beyond the Standard Model that arise from an effective Lagrangian which includes CP conserving and violating operators up to dimension six. We find that while leptonic distributions are very sensitive to anomalous couplings, because of the small cross-section involved, these analyses are feasible only after a high-luminosity upgrade of the LHC. We consider the cases of a 14 TeV, 33 TeV and 100 TeV machine and discuss the limits that can be placed on those couplings for different luminosities

  11. An Enhanced Box-Wing Solar Radiation pressure model for BDS and initial results

    Science.gov (United States)

    Zhao, Qunhe; Wang, Xiaoya; Hu, Xiaogong; Guo, Rui; Shang, Lin; Tang, Chengpan; Shao, Fan

    2016-04-01

    Solar radiation pressure forces are the largest non-gravitational perturbations acting on GNSS satellites, which is difficult to be accurately modeled due to the complicated and changing satellite attitude and unknown surface material characteristics. By the end of 2015, there are more than 50 stations of the Multi-GNSS Experiment(MGEX) set-up by the IGS. The simple box-plate model relies on coarse assumptions about the dimensions and optical properties of the satellite due to lack of more detailed information. So, a physical model based on BOX-WING model is developed, which is more sophisticated and more detailed physical structure has been taken into account, then calculating pressure forces according to the geometric relations between light rays and surfaces. All the MGEX stations and IGS core stations had been processed for precise orbit determination tests with GPS and BDS observations. Calculation range covers all the two kinds of Eclipsing and non-eclipsing periods in 2015, and we adopted the un-differential observation mode and more accurate values of satellite phase centers. At first, we tried nine parameters model, and then eliminated the parameters with strong correlation between them, came into being five parameters of the model. Five parameters were estimated, such as solar scale, y-bias, three material coefficients of solar panel, x-axis and z-axis panels. Initial results showed that, in the period of yaw-steering mode, use of Enhanced ADBOXW model results in small improvement for IGSO and MEO satellites, and the Root-Mean-Square(RMS) error value of one-day arc orbit decreased by about 10%~30% except for C08 and C14. The new model mainly improved the along track acceleration, up to 30% while in the radial track was not obvious. The Satellite Laser Ranging(SLR) validation showed, however, that this model had higher prediction accuracy in the period of orbit-normal mode, compared to GFZ multi-GNSS orbit products, as well with relative post

  12. FerryBox within the Coastal Observatory COSYNA: Examples of observations and potential benefit for data assimilation in hydrodynamic models

    Science.gov (United States)

    Petersen, W.; Staneva, J.; Grayek, S.; Schulz-Stellenfleth, J.; Stanev, E.

    2012-04-01

    The aim of the Coastal Observation System for Northern and Arctic Seas (COSYNA) is to obtain a synoptic description of the key state variables of coastal seas and their physical, chemical and ecological drivers and responses in the German Bight (North Sea). The system consists of a network of in situ observations, remote sensing, and coastal predictions systems. The modules of in-situ measurements will be briefly described. One of these major components for continuous observations are FerryBox systems aboard different types of ships as well as at fixed stations on shore. The long-term experiences with FerryBox systems for monitoring typical coastal processes will be presented by means of examples of observation. The benefit of FerryBox data compared to other observations will be critical assessed. Short term processes such as algal blooms or freshwater intrusions with subsequent higher nutrient loads at certain locations can be successfully monitored due to the high density of FerryBox measurements in space and time. From the same reason FerryBox data can be ideally combined with hydrodynamic models using data assimilation techniques. The potential of FerryBox sea surface temperature (SST) and salinity (SSS) measurements for the improvement of model state estimates in the German Bight will be shown critically assessed. Model-data comparison shows that the reanalysis produced by data assimilation fairly well represents the physical properties in the German Bight. The overall root-mean-square errors between temperature and salinity fields of reanalysis and observation are significantly reduced after the assimilation of the FerryBox data. Furthermore, seasonal variation in temperature is well reproduced and the predicted synoptic variation is significantly correlated with its counterpart from the mooring measured temperature.

  13. Technology Solutions Case Study: New Insights for Improving the Designs of Flexible Duct Junction Boxes

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-01-01

    In this project, IBACOS explored the relationships between pressure and physical configurations of flexible duct junction boxes by using computational fluid dynamics simulations to predict individual box parameters and total system pressure, thereby ensuring improved HVAC performance.

  14. Modeling of flow dynamics in layered groundwater system: Comparative evaluation of black box and numerical approaches

    International Nuclear Information System (INIS)

    The numerical flow and transport models are used to calculate the streamline distribution in the aquifer and the tracer concentration in the outflow from the system for the groundwater aquifer consists of parallel layers with different hydraulic conductivity. Infiltration takes place through the whole aquifer surface and the aquifer is drainaged by the river (constant head). Using the streamline distribution calculated using numerical model of water flow, the distribution of the transit time of water particle through the aquifer is constructed. These distribution functions calculated for different imagine aquifers are compared with the well known distribution functions of Black-Box-Model (BBM) approach. In that way it was found which of BBM functions approximates the real hydrological situation with the best accuracy. It was also found the relation of the mean transit time of water to the aquifer parameters. Additionally, the numerical transport model was applied for the continuous injection of ideal tracer through the aquifer surface and the calculated weighted concentrations found for the outflow (river) were taken into BBM modeling. It was found which BBM model can be calibrated to the observed output concentrations and what is the value of the mean transit time of water through the aquifer. The aquifer parameters obtained by applying distribution functions to the numerical modeling of water flow and by applying BBM to the transport modeling, are compared with the real parameters of the aquifers being considered. (author)

  15. In-service parametric modelling a rail vehicle's axle-box hydraulic damper for high-speed transit problems

    Science.gov (United States)

    Wang, W. L.; Yu, D. S.; Zhou, Z.

    2015-10-01

    Due to the high-speed operation of modern rail vehicles and severe in-service environment of their hydraulic dampers, it has become important to establish more practical and accurate damper models and apply those models in high-speed transit problem studies. An improved full parametric model with actual in-service parameters, such as variable viscous damping, comprehensive stiffness and small mounting clearance was established for a rail vehicle's axle-box hydraulic damper. A subtle variable oil property model was built and coupled to the modelling process, which included modelling of the dynamic flow losses and the relief-valve system dynamics. The experiments validated the accuracy and robustness of the established full in-service parametric model and simulation which captured the damping characteristics over an extremely wide range of excitation speeds. Further simulations were performed using the model to uncover the effects of key in-service parameter variations on the nominal damping characteristics of the damper. The obtained in-service parametric model coupled all of the main factors that had significant impacts on the damping characteristics, so that the model could be useful in more extensive parameter effects analysis, optimal specification and product design optimisation of hydraulic dampers for track-friendliness, ride comfort and other high-speed transit problems.

  16. A Case Study of Black-Box Testing for Embedded Software using Test Automation Tool

    OpenAIRE

    Changhyun Baek; Joongsoon Jang; Gihyun Jung; Kyunghee Choi; Seungkyu Park

    2007-01-01

    This research shows a case study of the Black-Box testing for Temperature Controller (TC) which is one of the typical embedded systems. A test automation tool, TEST, was developed and some kinds of TCs were tested using the tool. We presented statistical analysis for the test results of the automated testing and defined the properties of the software bugs for the embedded system. The main result of the study were the following: (a) test case prioritization technique was needed because the rev...

  17. Why the Particle-in-a-Box Model Works Well for Cyanine Dyes but Not for Conjugated Polyenes

    Science.gov (United States)

    Autschbach, Jochen

    2007-01-01

    We investigate why the particle-in-a-box (PB) model works well for calculating the absorption wavelengths of cyanine dyes and why it does not work for conjugated polyenes. The PB model is immensely useful in the classroom, but owing to its highly approximate character there is little reason to expect that it can yield quantitative agreement with…

  18. Probabilistic Analysis of Onion Routing in a Black-box Model

    CERN Document Server

    Feigenbaum, Joan; Syverson, Paul

    2011-01-01

    We perform a probabilistic analysis of onion routing. The analysis is presented in a black-box model of anonymous communication in the Universally Composable framework that abstracts the essential properties of onion routing in the presence of an active adversary that controls a portion of the network and knows all a priori distributions on user choices of destination. Our results quantify how much the adversary can gain in identifying users by exploiting knowledge of their probabilistic behavior. In particular, we show that, in the limit as the network gets large, a user u's anonymity is worst either when the other users always choose the destination u is least likely to visit or when the other users always choose the destination u chooses. This worst-case anonymity with an adversary that controls a fraction b of the routers is shown to be comparable to the best-case anonymity against an adversary that controls a fraction \\surdb.

  19. Real-time process optimization based on grey-box neural models

    Directory of Open Access Journals (Sweden)

    F. A. Cubillos

    2007-09-01

    Full Text Available This paper investigates the feasibility of using grey-box neural models (GNM in Real Time Optimization (RTO. These models are based on a suitable combination of fundamental conservation laws and neural networks, being used in at least two different ways: to complement available phenomenological knowledge with empirical information, or to reduce dimensionality of complex rigorous physical models. We have observed that the benefits of using these simple adaptable models are counteracted by some difficulties associated with the solution of the optimization problem. Nonlinear Programming (NLP algorithms failed in finding the global optimum due to the fact that neural networks can introduce multimodal objective functions. One alternative considered to solve this problem was the use of some kind of evolutionary algorithms, like Genetic Algorithms (GA. Although these algorithms produced better results in terms of finding the appropriate region, they took long periods of time to reach the global optimum. It was found that a combination of genetic and nonlinear programming algorithms can be use to fast obtain the optimum solution. The proposed approach was applied to the Williams-Otto reactor, considering three different GNM models of increasing complexity. Results demonstrated that the use of GNM models and mixed GA/NLP optimization algorithms is a promissory approach for solving dynamic RTO problems.

  20. Simulation of atmospheric mercury depletion events (AMDEs during polar springtime using the MECCA box model

    Directory of Open Access Journals (Sweden)

    Z.-Q. Xie

    2008-07-01

    Full Text Available Atmospheric mercury depletion events (AMDEs during polar springtime are closely correlated with bromine-catalyzed tropospheric ozone depletion events (ODEs. To study gas- and aqueous-phase reaction kinetics and speciation of mercury during AMDEs, we have included mercury chemistry into the box model MECCA (Module Efficiently Calculating the Chemistry of the Atmosphere, which enables dynamic simulation of bromine activation and ODEs.

    We found that the reaction of Hg with Br atoms dominates the loss of gaseous elemental mercury (GEM. To explain the experimentally observed synchronous destruction of Hg and O3, the reaction rate of Hg+BrO has to be much lower than that of Hg+Br. The synchronicity is best reproduced with rate coefficients at the lower limit of the literature values for both reactions, i.e. kHg+Br≈3×10-13 and kHg+BrO≤1×10-15cm3 mol-1 s-1, respectively.

    Throughout the simulated AMDEs, BrHgOBr was the most abundant reactive mercury species, both in the gas phase and in the aqueous phase. The aqueous phase concentrations of BrHgOBr, HgBr2, and HgCl2 were several orders of magnitude larger than that of Hg(SO32-2.

    Considering chlorine chemistry outside depletion events (i.e. without bromine activation, the concentration of total divalent mercury in sea-salt aerosol particles (mostly HgCl2 was much higher than in dilute aqueous droplets (mostly Hg(SO32-2, and did not exhibit a diurnal cycle (no correlation with HO2 radicals.

  1. Computational modelling of six speed hybrid gear box and its simulation using Simulinkas an interactive tool of MATLAB

    Directory of Open Access Journals (Sweden)

    Devesh Ramphal Upadhyay

    2016-02-01

    Full Text Available The paper introduces an idea which adds itself into contribution of getting best fuel economy of a passenger car when it is running at high speed on a highway. A six speed (forward gear box is addressed in the paper which is controlled manually and automatically as well. The paper introduces an advancement in manual transmission gear box for passenger cars. Hydraulic circuit is designed with mechatronics point of view and resulting in making the shifting of gear automatically. A computational design is made of the Hybrid Gear Box (HGB using CATIA P3 V5 as a designing software. A new gear meshing in 5 speed manual transmission gear box which synchronizes with the output shaft of the transmission automatically after getting command by the automated system designed. Parameters are considered on the basis of practical model and is been simulated by using Simdriveline as the Simulink tool of MATLAB r2010a. The mechanical properties of the components of the hybrid gear box is calculated on the basis of the functional parameters and with help of the fundamental and dependent properties formulation. The final result is the graphical analysis of the model forobtaining at least 15% fuel efficient than any of the vehicle of same configurations.

  2. Cortical responses to the mirror box illusion: a high-resolution EEG study.

    Science.gov (United States)

    Egsgaard, Line Lindhardt; Petrini, Laura; Christoffersen, Giselle; Arendt-Nielsen, Lars

    2011-12-01

    The mirror box illusion has proven a helpful therapy in pathologies such as phantom limb pain, and although the effect has been suggested to be a result of the interaction between pain, vision, touch, and proprioception, the mechanisms are still unknown. Multichannel (124) brain responses were investigated in healthy men (N = 11) and women (N = 14) during the mirror box illusion. Tactile somatosensory evoked potentials were recorded from the right thumb during two control conditions and two illusions: (control 1) no mirror: looking at the physical right thumb during stimulation, (control 2) no mirror: looking at the physical left thumb during stimulation, (illusion 1) mirror: the illusion that both thumbs were stimulated, and (illusion 2) mirror: the illusion that none of the thumbs were stimulated. In men, a significant medial shift in the y coordinate of the N70 dipole in illusion 2 (P = 0.021) was found when compared with illusion 1. No dipole shift was found for women. Additionally, men showed higher prevalence of P180 cingulate cortex activation during illusion 2 when compared with control 1 and 2 (P = 0.002). During illusion 2, the degree of conformity with the statement "The hand in the mirror feels like my other hand" was negatively correlated with the N70 x coordinate for men and positively correlated with the N70 z coordinate for women. In conclusion, short-term cortical plasticity can be induced by a mismatch between visual input and location of tactile stimulation in men. The present study suggests that gender differences exist in the perception of the mirror box illusion. PMID:22038713

  3. Automatic Black-Box Model Order Reduction using Radial Basis Functions

    Energy Technology Data Exchange (ETDEWEB)

    Stephanson, M B; Lee, J F; White, D A

    2011-07-15

    Finite elements methods have long made use of model order reduction (MOR), particularly in the context of fast freqeucny sweeps. In this paper, we discuss a black-box MOR technique, applicable to a many solution methods and not restricted only to spectral responses. We also discuss automated methods for generating a reduced order model that meets a given error tolerance. Numerical examples demonstrate the effectiveness and wide applicability of the method. With the advent of improved computing hardware and numerous fast solution techniques, the field of computational electromagnetics are progressed rapidly in terms of the size and complexity of problems that can be solved. Numerous applications, however, require the solution of a problem for many different configurations, including optimization, parameter exploration, and uncertainly quantification, where the parameters that may be changed include frequency, material properties, geometric dimensions, etc. In such cases, thousands of solutions may be needed, so solve times of even a few minutes can be burdensome. Model order reduction (MOR) may alleviate this difficulty by creating a small model that can be evaluated quickly. Many MOR techniques have been applied to electromagnetic problems over the past few decades, particularly in the context of fast frequency sweeps. Recent works have extended these methods to allow more than one parameter and to allow the parameters to represent material and geometric properties. There are still limitations with these methods, however. First, they almost always assume that the finite element method is used to solve the problem, so that the system matrix is a known function of the parameters. Second, although some authors have presented adaptive methods (e.g., [2]), the order of the model is often determined before the MOR process begins, with little insight about what order is actually needed to reach the desired accuracy. Finally, it not clear how to efficiently extend most

  4. Simulating atmospheric composition over a South-East Asian tropical rainforest: performance of a chemistry box model

    Science.gov (United States)

    Pugh, T. A. M.; MacKenzie, A. R.; Hewitt, C. N.; Langford, B.; Edwards, P. M.; Furneaux, K. L.; Heard, D. E.; Hopkins, J. R.; Jones, C. E.; Karunaharan, A.; Lee, J.; Mills, G.; Misztal, P.; Moller, S.; Monks, P. S.; Whalley, L. K.

    2010-01-01

    Atmospheric composition and chemistry above tropical rainforests is currently not well established, particularly for south-east Asia. In order to examine our understanding of chemical processes in this region, the performance of a box model of atmospheric boundary layer chemistry is tested against measurements made at the top of the rainforest canopy near Danum Valley, Malaysian Borneo. Multi-variate optimisation against ambient concentration measurements was used to estimate average canopy-scale emissions for isoprene, total monoterpenes and nitric oxide. The excellent agreement between estimated values and measured fluxes of isoprene and total monoterpenes provides confidence in the overall modelling strategy, and suggests that this method may be applied where measured fluxes are not available, assuming that the local chemistry and mixing are adequately understood. The largest contributors to the optimisation cost function at the point of best-fit are OH (29%), NO (22%) and total peroxy radicals (27%). Several factors affect the modelled VOC chemistry. In particular concentrations of methacrolein (MACR) and methyl-vinyl ketone (MVK) are substantially overestimated, and the hydroxyl radical (OH) concentration is substantially underestimated; as has been seen before in tropical rainforest studies. It is shown that inclusion of dry deposition of MACR and MVK and wet deposition of species with high Henry's Law values substantially improves the fit of these oxidised species, whilst also substantially decreasing the OH sink. Increasing OH production arbitrarily, through a simple OH recycling mechanism , adversely affects the model fit for volatile organic compounds (VOCs). Given the constraints on isoprene flux provided by measurements, a substantial decrease in the rate of reaction of VOCs with OH is the only remaining option to explain the measurement/model discrepancy for OH. A reduction in the isoprene+OH rate constant of 50%, in conjunction with increased

  5. Simulating atmospheric composition over a South-East Asian tropical rainforest: Performance of a chemistry box model

    Directory of Open Access Journals (Sweden)

    T. A. M. Pugh

    2009-09-01

    Full Text Available Atmospheric composition and chemistry above tropical rainforests is currently not well established, particularly for south-east Asia. In order to examine our understanding of chemical processes in this region, the performance of a box model of atmospheric boundary layer chemistry is tested against measurements made at the top of the rainforest canopy near Danum Valley, Malaysian Borneo. Multi-variate optimisation against ambient concentration measurements was used to estimate average canopy-scale emissions for isoprene, total monoterpenes and nitric oxide. The excellent agreement between estimated values and measured fluxes of isoprene and total monoterpenes provides confidence in the overall modelling strategy, and suggests that this method may be applied where measured fluxes are not available. The largest contributors to the optimisation cost function at the point of best-fit are OH (41%, NO (18% and total monoterpenes (16%. Several factors affect the modelled VOC chemistry. In particular concentrations of methacrolein (MACR and methyl-vinyl ketone (MVK are substantially overestimated, and the hydroxyl radical [OH] concentration is substantially underestimated; as has been seen before in tropical rainforest studies. It is shown that inclusion of dry deposition of MACR and MVK and wet deposition of species with high Henry's Law values substantially improves the fit of these oxidised species, whilst also substantially decreasing the OH sink. Increasing [OH] production arbitrarily, through a simple OH recycling mechanism, adversely affects the model fit for volatile organic compounds (VOCs. Given the constraints on isoprene flux provided by measurements, a substantial decrease in the rate of reaction of VOCs with OH is the only remaining option to explain the measurement/model discrepancy for OH. A reduction in the isoprene + OH rate constant of 50–70% is able to produce both isoprene and OH concentrations within error of those measured

  6. Simulating atmospheric composition over a South-East Asian tropical rainforest: performance of a chemistry box model

    Directory of Open Access Journals (Sweden)

    T. A. M. Pugh

    2010-01-01

    Full Text Available Atmospheric composition and chemistry above tropical rainforests is currently not well established, particularly for south-east Asia. In order to examine our understanding of chemical processes in this region, the performance of a box model of atmospheric boundary layer chemistry is tested against measurements made at the top of the rainforest canopy near Danum Valley, Malaysian Borneo. Multi-variate optimisation against ambient concentration measurements was used to estimate average canopy-scale emissions for isoprene, total monoterpenes and nitric oxide. The excellent agreement between estimated values and measured fluxes of isoprene and total monoterpenes provides confidence in the overall modelling strategy, and suggests that this method may be applied where measured fluxes are not available, assuming that the local chemistry and mixing are adequately understood. The largest contributors to the optimisation cost function at the point of best-fit are OH (29%, NO (22% and total peroxy radicals (27%. Several factors affect the modelled VOC chemistry. In particular concentrations of methacrolein (MACR and methyl-vinyl ketone (MVK are substantially overestimated, and the hydroxyl radical (OH concentration is substantially underestimated; as has been seen before in tropical rainforest studies. It is shown that inclusion of dry deposition of MACR and MVK and wet deposition of species with high Henry's Law values substantially improves the fit of these oxidised species, whilst also substantially decreasing the OH sink. Increasing OH production arbitrarily, through a simple OH recycling mechanism , adversely affects the model fit for volatile organic compounds (VOCs. Given the constraints on isoprene flux provided by measurements, a substantial decrease in the rate of reaction of VOCs with OH is the only remaining option to explain the measurement/model discrepancy for OH. A reduction in the isoprene+OH rate constant of 50%, in conjunction with

  7. A Case Study of Black-Box Testing for Embedded Software using Test Automation Tool

    Directory of Open Access Journals (Sweden)

    Changhyun Baek

    2007-01-01

    Full Text Available This research shows a case study of the Black-Box testing for Temperature Controller (TC which is one of the typical embedded systems. A test automation tool, TEST, was developed and some kinds of TCs were tested using the tool. We presented statistical analysis for the test results of the automated testing and defined the properties of the software bugs for the embedded system. The main result of the study were the following: (a test case prioritization technique was needed because the review phase, in the test process, takes long time; (b there are three types of software defects for the embedded software; (c the complexity of the system configuration have an effect on the software de-fect; (d the software defect was distributed in vulnerable points of the software; and (e testing activi-ties reduce the number of the software defects. The result can be useful in the asymptotic study of test case prioritization.

  8. Business intelligence from social media: a study from the VAST Box Office Challenge.

    Science.gov (United States)

    Lu, Yafeng; Wang, Feng; Maciejewski, Ross

    2014-01-01

    With over 16 million tweets per hour, 600 new blog posts per minute, and 400 million active users on Facebook, businesses have begun searching for ways to turn real-time consumer-based posts into actionable intelligence. The goal is to extract information from this noisy, unstructured data and use it for trend analysis and prediction. Current practices support the idea that visual analytics (VA) can help enable the effective analysis of such data. However, empirical evidence demonstrating the effectiveness of a VA solution is still lacking. A proposed VA toolkit extracts data from Bitly and Twitter to predict movie revenue and ratings. Results from the 2013 VAST Box Office Challenge demonstrate the benefit of an interactive environment for predictive analysis, compared to a purely statistical modeling approach. The VA approach used by the toolkit is generalizable to other domains involving social media data, such as sales forecasting and advertisement analysis. PMID:25248200

  9. A boxing-oriented exercise intervention for obese adolescent males: findings from a pilot study.

    Science.gov (United States)

    Shultz, Sarah P; Stoner, Lee; Lambrick, Danielle M; Lane, Andrew M

    2014-12-01

    In New Zealand, obese Māori and Pasifika adolescents are at risk of numerous cardio-metabolic conditions with raising physical activity levels being proposed as a useful intervention. The present study used a mixed method design to explore the effects of a non-contact boxing-oriented training programme designed in terms of improvements to cardio-metabolic variables. Traditional recruitment strategies (media, referrals) were employed, with limited success leading to 3 adolescent boys (14-15 y) participating in the pilot intervention. Exercise sessions included 30 minutes of non-contact boxing training, followed by 30 minutes of progressive resistance training. Participants attended three 1h training sessions each week, for a total of 12 weeks. Physiological variables included anthropometric indices, visceral fat thickness, central blood pressures, central arterial stiffness (augmentation index: AIx), and carotid arterial stiffness (β). Results revealed that there was no trend for change in body weight (125.5 ± 12.1 kg vs. 126.5 ± 11.0 kg) or BMI (39.3 ± 4.1 kg·m(-2) vs. 39.0 ± 4.6 kg·m(-2)). However, there was a moderate decrease in visceral fat thickness (4.34 ± 2.51 cm vs 3.65 ± 1.11 cm, d = 0.36). There was no change in central pulse pressure (38.7 ± 7.3 mmHg vs. 38.3 ± 5.0 mmHg), however, there was a small improvement in β (3.01 ± 0.73 vs. 2.87 ± 0.84, d = 0.18). Focus group interview data with participants and their parents were used to explore issues related to motivation to participation. Results revealed participants commented on how the programme has led to new friendships, changes to their physical appearance, and increased physical fitness. Parents commented on increased self-confidence, better performance in school, and a willingness to take part in new activities. In conclusion, it appears participating in the boxing oriented training programme was motivating to participants who engaged and had some physiological benefits in obese

  10. Quantifying atmospheric transport, chemistry, and mixing using a new trajectory-box model and a global atmospheric-chemistry GCM

    Directory of Open Access Journals (Sweden)

    H. Riede

    2009-12-01

    Full Text Available We present a novel method for the quantification of transport, chemistry, and mixing along atmospheric trajectories based on a consistent model hierarchy. The hierarchy consists of the new atmospheric-chemistry trajectory-box model CAABA/MJT and the three-dimensional (3-D global ECHAM/MESSy atmospheric-chemistry (EMAC general circulation model. CAABA/MJT employs the atmospheric box model CAABA in a configuration using the atmospheric-chemistry submodel MECCA (M, the photochemistry submodel JVAL (J, and the new trajectory submodel TRAJECT (T, to simulate chemistry along atmospheric trajectories, which are provided offline. With the same chemistry submodels coupled to the 3-D EMAC model and consistent initial conditions and physical parameters, a unique consistency between the two models is achieved. Since only mixing processes within the 3-D model are excluded from the model consistency, comparisons of results from the two models allow to separate and quantify contributions of transport, chemistry, and mixing along the trajectory pathways. Consistency of transport between the trajectory-box model CAABA/MJT and the 3-D EMAC model is achieved via calculation of kinematic trajectories based on 3-D wind fields from EMAC using the trajectory model LAGRANTO. The combination of the trajectory-box model CAABA/MJT and the trajectory model LAGRANTO can be considered as a Lagrangian chemistry-transport model (CTM moving isolated air parcels. The procedure for obtaining the necessary statistical basis for the quantification method is described as well as the comprehensive diagnostics with respect to chemistry.

    The quantification method presented here allows to investigate the characteristics of transport, chemistry, and mixing in a grid-based 3-D model. The analysis of chemical processes within the trajectory-box model CAABA/MJT is easily extendable to include, for example, the impact of different transport pathways or of mixing processes onto

  11. The Y-Box Binding Protein 1 Suppresses Alzheimer's Disease Progression in Two Animal Models.

    Directory of Open Access Journals (Sweden)

    N V Bobkova

    Full Text Available The Y-box binding protein 1 (YB-1 is a member of the family of DNA- and RNA binding proteins. It is involved in a wide variety of DNA/RNA-dependent events including cell proliferation and differentiation, stress response, and malignant cell transformation. Previously, YB-1 was detected in neurons of the neocortex and hippocampus, but its precise role in the brain remains undefined. Here we show that subchronic intranasal injections of recombinant YB-1, as well as its fragment YB-11-219, suppress impairment of spatial memory in olfactory bulbectomized (OBX mice with Alzheimer's type degeneration and improve learning in transgenic 5XFAD mice used as a model of cerebral amyloidosis. YB-1-treated OBX and 5XFAD mice showed a decreased level of brain β-amyloid. In OBX animals, an improved morphological state of neurons was revealed in the neocortex and hippocampus; in 5XFAD mice, a delay in amyloid plaque progression was observed. Intranasally administered YB-1 penetrated into the brain and could enter neurons. In vitro co-incubation of YB-1 with monomeric β-amyloid (1-42 inhibited formation of β-amyloid fibrils, as confirmed by electron microscopy. This suggests that YB-1 interaction with β-amyloid prevents formation of filaments that are responsible for neurotoxicity and neuronal death. Our data are the first evidence for a potential therapeutic benefit of YB-1 for treatment of Alzheimer's disease.

  12. DETECTION OF EXTRA-NUCLEAR HIGH MOBILITY GROUP BOX-1 PROTEIN IN A CANINE MODEL OF MYOCARDIAL INFARCTION

    Science.gov (United States)

    The high mobility group box-1 protein (HMGB-1) is a well-characterized nuclear protein recently shown to be involved in endotoxin-induced inflammation and injury. Studies have linked HMGB-1 release to the production of pro-inflammatory cytokines; however, a role for HMGB-1 in other disorders involvi...

  13. A Boxing-Oriented Exercise Intervention for Obese Adolescent Males: Findings from a Pilot Study

    Directory of Open Access Journals (Sweden)

    Sarah P. Shultz, Lee Stoner, Danielle M. Lambrick, Andrew M. Lane

    2014-12-01

    Full Text Available In New Zealand, obese Māori and Pasifika adolescents are at risk of numerous cardio-metabolic conditions with raising physical activity levels being proposed as a useful intervention. The present study used a mixed method design to explore the effects of a non-contact boxing-oriented training programme designed in terms of improvements to cardio-metabolic variables. Traditional recruitment strategies (media, referrals were employed, with limited success leading to 3 adolescent boys (14-15 y participating in the pilot intervention. Exercise sessions included 30 minutes of non-contact boxing training, followed by 30 minutes of progressive resistance training. Participants attended three 1h training sessions each week, for a total of 12 weeks. Physiological variables included anthropometric indices, visceral fat thickness, central blood pressures, central arterial stiffness (augmentation index: AIx, and carotid arterial stiffness (β. Results revealed that there was no trend for change in body weight (125.5 ± 12.1 kg vs. 126.5 ± 11.0 kg or BMI (39.3 ± 4.1 kg·m-2 vs. 39.0 ± 4.6 kg·m-2. However, there was a moderate decrease in visceral fat thickness (4.34 ± 2.51 cm vs 3.65 ± 1.11 cm, d = 0.36. There was no change in central pulse pressure (38.7 ± 7.3 mmHg vs. 38.3 ± 5.0 mmHg, however, there was a small improvement in β (3.01 ± 0.73 vs. 2.87 ± 0.84, d = 0.18. Focus group interview data with participants and their parents were used to explore issues related to motivation to participation. Results revealed participants commented on how the programme has led to new friendships, changes to their physical appearance, and increased physical fitness. Parents commented on increased self-confidence, better performance in school, and a willingness to take part in new activities. In conclusion, it appears participating in the boxing oriented training programme was motivating to participants who engaged and had some physiological benefits in obese

  14. A Study of the B/C Ratio Between 10 MeV/nuc and 1 TeV/nuc in Cosmic Rays Using New Voyager and AMS-2 Data and a Comparison with the Predictions of Leaky Box Propagation Models

    CERN Document Server

    Webber, W R

    2016-01-01

    This paper seeks to find an explanation of the galactic cosmic ray B/C ratio newly measured in cosmic rays between ~10 MeV/nuc and 1 TeV/nuc. Voyager measurements of this ratio at low energies and AMS-2 measurements at high energies are used in this study. These measurements both considerably exceed at both low and high energies the ratio predicted using a simple Leaky Box Model for propagation of cosmic rays in the galaxy. Between 1-70 GeV/nuc, however, this same model provides an excellent fit (within +2-3%) to the new AMS-2 measurements using an escape length ~P-0.45. This would imply a diffusion coefficient ~P0.45, very close to the Kraichian cascade value of 0.50 for the exponent. Extending this same diffusion dependence to high energies, still in a LBM, along with a truncation of short path lengths in the galaxy will predict a B/C ratio of 4.5% at ~800 GeV/nuc which is very close to the AMS-2 measurement at that energy. This would indicate that the amount of material traversed near the source in a Neste...

  15. Seismic stability of a standalone glove box structure

    International Nuclear Information System (INIS)

    Highlights: • Glove box is a leak tight, safety related structure used for handling radiotoxic materials. • To study the seismic performance of a freestanding glove box, extensive shake table testing has been carried out. • Glove box maintained structural integrity and leak tightness up to design basis earthquake loading. • Detailed three-dimensional finite element model of the structure is developed and analyzed by using direct time integration methods. • Simplified numerical method is proposed and successfully applied, to quickly estimate sliding displacement and determine upper bounds for it. - Abstract: In a nuclear fuel cycle facility, radiotoxic materials are being handled in freestanding leak tight enclosures called glove boxes (GBs). These glove boxes act as a primary confinement for the radiotoxic materials. Glove boxes are designed as per codal requirements for class I component. They are designed to withstand extreme level of earthquake loading with a return period of 10,000 years. To evaluate seismic performance of the glove box, there is a need to check the stability (sliding and overturning), structural integrity (stresses and strains) and leak tightness under earthquake loading. Extensive shake table experiments were conducted on a single standalone glove box. Actual laboratory conditions were simulated during testing to check the response. After extensive shake table testing, glove box structure was also analyzed using finite element (FE) software. Detailed three-dimensional model of glove box structure was developed and analyzed using nonlinear time history method. It was observed that finite element methods could be utilized to accurately predict dynamic response of glove box structure. This paper discusses the details and results of shake table testing and methodology used for modelling and analysing freestanding glove box structure under seismic loading. In addition, simplified numerical procedure, developed using energy conservation

  16. Seismic stability of a standalone glove box structure

    Energy Technology Data Exchange (ETDEWEB)

    Saraswat, A., E-mail: anupams@barc.gov.in [Bhabha Atomic Research Centre, Mumbai (India); Reddy, G.R. [Bhabha Atomic Research Centre, Mumbai (India); Ghosh, S. [Indian Institute of Technology Bombay, Mumbai (India); Ghosh, A.K.; Kumar, Arun [Bhabha Atomic Research Centre, Mumbai (India)

    2014-09-15

    Highlights: • Glove box is a leak tight, safety related structure used for handling radiotoxic materials. • To study the seismic performance of a freestanding glove box, extensive shake table testing has been carried out. • Glove box maintained structural integrity and leak tightness up to design basis earthquake loading. • Detailed three-dimensional finite element model of the structure is developed and analyzed by using direct time integration methods. • Simplified numerical method is proposed and successfully applied, to quickly estimate sliding displacement and determine upper bounds for it. - Abstract: In a nuclear fuel cycle facility, radiotoxic materials are being handled in freestanding leak tight enclosures called glove boxes (GBs). These glove boxes act as a primary confinement for the radiotoxic materials. Glove boxes are designed as per codal requirements for class I component. They are designed to withstand extreme level of earthquake loading with a return period of 10,000 years. To evaluate seismic performance of the glove box, there is a need to check the stability (sliding and overturning), structural integrity (stresses and strains) and leak tightness under earthquake loading. Extensive shake table experiments were conducted on a single standalone glove box. Actual laboratory conditions were simulated during testing to check the response. After extensive shake table testing, glove box structure was also analyzed using finite element (FE) software. Detailed three-dimensional model of glove box structure was developed and analyzed using nonlinear time history method. It was observed that finite element methods could be utilized to accurately predict dynamic response of glove box structure. This paper discusses the details and results of shake table testing and methodology used for modelling and analysing freestanding glove box structure under seismic loading. In addition, simplified numerical procedure, developed using energy conservation

  17. Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model

    Directory of Open Access Journals (Sweden)

    Chih-Zen Chang

    2014-01-01

    Full Text Available High-mobility group box 1 (HMGB1 was shown to be an important extracellular mediator involved in vascular inflammation of animals following subarachnoid hemorrhage (SAH. This study is of interest to examine the efficacy of purpurogallin, a natural phenol, on the alternation of cytokines and HMGB1 in a SAH model. A rodent double hemorrhage SAH model was employed. Basilar arteries (BAs were harvested to examine HMGB1 mRNA and protein expression (Western blot. CSF samples were to examine IL-1β, IL-6, IL-8, and TNF-α (rt-PCR. Deformed endothelial wall, tortuous elastic lamina, and necrotic smooth muscle were observed in the vessels of SAH groups but were absent in the purpurogallin group. IL-1β, IL-6, and TNF-α in the SAH only and SAH plus vehicle groups were significantly elevated (P<0.01. Purpurgallin dose-dependently reduced HMGB1 protein expression. Likewise, high dose purpurogallin reduced TNF-α and HMGB1 mRNA levels. In conclusion, purpurogallin exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression. This study supports purpurogallin could attenuate both proinflammatory cytokines and late-onset inflammasome in SAH induced vasospasm.

  18. Loads experiments study on two-story RC box and truncated conical walls

    International Nuclear Information System (INIS)

    The failure modes of the two specimens were the sliding shear failure. The two specimens showed almost equal deformation at the maximum shear strength. The ratio of the flexural deformation in the deformation of the truncated conical was larger than that of the box wall. The ratio of the shear deformation in the deformation of the two-story RC box wall was larger than that of the flexural deformation. (orig./HP)

  19. A Time-Dependent SPICE Model for Single Electron Box and Its Application to Logic Gates at Low and High Temperatures

    International Nuclear Information System (INIS)

    In this paper, for the first time, a circuit model for single electron box (SEB) is introduced. The main feature of the proposed model is mapping the master equation, which explains the behavior of a single electron device, to a novel circuit model. The proposed model can be utilized in a circuit simulator such as SPICE. The proposed circuit model is a time dependent model which can be used in order to calculate the intrinsic time latency of the SEB. In addition, it is able to calculate the operation of a gate circuit in high temperatures. The correct operation of the proposed model is studied by utilizing the model for simulating two digital logic gates based on the SEB. The obtained results are compared with SIMON.

  20. Development of a lower body negative pressure box with an environmental control system for physiological studies.

    Science.gov (United States)

    Russomano, T; Falcao, F; Gurgel, J; Piccoli, L; Porto, F; Dalmarco, G; de Azevedo, D F G; Allan, J; Beck, L; Petrat, G; Thompsen, S

    2005-01-01

    A headward fluid shift occurs during microgravity exposure, which causes the cardiovascular adaptive syndrome. Different countermeasures have been proposed to decrease its symptomatology, like the application of lower body negative pressure (LBNP). A LBNP box with an environment control system was developed, aiming to improve features of LBNP boxes used worldwide. It consists of five carbon steel ribs in the shape of a cylinder, which is wrapped with high pressure resistant and transparent vinyl. Inner and outer-wheeled trolleys can comfortably and easily move the subject in and out of the box. A custom-made skirt is secured around the subject's waist by an adjustable belt. The other end is secured between two window-type wooden structures, which seal the LBNP box. Inlet and an outlet valves connect the external to the internal environment of the chamber and tube system allows air to circulate gently. Electronic sensors are used to adjust the airflow keeping a pre-set negative pressure without changing humidity and temperature inside the box. Structural, pressure profile and leaking tests were performed with successful results. The improvements of the present LBNP box have substantially decreased the undesirable side effects of uncontrolled environment conditions during rapid pressure changes, and increased test subjects' comfort. PMID:17281238

  1. Perspectives on the policy 'black box': a comparative case study of orthopaedics services in England.

    Science.gov (United States)

    McLeod, Hugh; Millar, Ross; Goodwin, Nick; Powell, Martin

    2014-10-01

    There has been much recent debate on the impact of competition on the English National Health Service (NHS). However, studies have tended to view competition in isolation and are controversial. This study examines the impact of programme theories associated with the health system reforms, which sought to move from a dominant target-led 'central control' programme theory, to one based on 'market forces', on orthopaedics across six case-study local health economies. It draws on a realistic evaluation approach to open up the policy 'black box' across different contexts using a mixed methods approach: analysis of 152 interviews with key informants and analysis of waiting times and admissions. We find that the urban health economies were more successful in reaching the access targets than the rural health economies, although the gap in performance closed over time. Most interviewees were aware of the policies to increase choice and competition, but their role appeared comparatively weak. Local commissioners' ability to influence demand appeared limited with providers' incentives dominating service delivery. Looking forward, it is clear that the role of competition in the NHS has to be considered alongside, rather than in isolation from, other policy mechanisms. PMID:24556091

  2. Response surface methodology (RSM) modeling of microwave-assisted extraction of natural dye from Swietenia mahagony: A comparation between Box-Behnken and central composite design method

    Science.gov (United States)

    Kusuma, Heri Septya; Sudrajat, Robby Ginanjar Margo; Susanto, David Febrilliant; Gala, Selfina; Mahfud, Mahfud

    2015-12-01

    The increasing demand of non-toxic and environmentally friendly dyes, colorants that come from natural source have risen as an alternative of sintetic poisonous dyes. In this research natural dye from S. mahagony was extracted using microwave-assisted extraction method under different operating condition such as extraction time (10-30min), plant material to solvent ratio (0.03-0.05g/mL) and microwave power level (100-380 watt). Box-Behnken method and central composite design (CCD) method is widely used for modeling response surface methodology (RSM), both methods show good prediction performance. In this study response surface methodology was performed to optimize the process, both methods were performed by the help Statgraphics Centurion 16 to evaluate the effects of different operating parameters. Finally, both methods were statistically compared by root mean square error (RMSE) and absolute average deviation (AAD) based on validation data set. Further, result suggests that CCD has better performance as compared to Box-Behnken method. The maximum yield obtained for Box-Behnken is 3.7647% (380 watt, 0.0339g/mL, 28.8899min) and 3.7506% (379.986 watt, 0.0378g/mL, 30min) for central composite design method.

  3. Scientific models red atoms, white lies and black boxes in a yellow book

    CERN Document Server

    Gerlee, Philip

    2016-01-01

    A zebrafish, the hull of a miniature ship, a mathematical equation and a food chain - what do these things have in common? They are examples of models used by scientists to isolate and study particular aspects of the world around us. This book begins by introducing the concept of a scientific model from an intuitive perspective, drawing parallels to mental models and artistic representations. It then recounts the history of modelling from the 16th century up until the present day. The iterative process of model building is described and discussed in the context of complex models with high predictive accuracy versus simpler models that provide more of a conceptual understanding. To illustrate the diversity of opinions within the scientific community, we also present the results of an interview study, in which ten scientists from different disciplines describe their views on modelling and how models feature in their work. Lastly, it includes a number of worked examples that span different modelling approaches a...

  4. Radiometric studies of box cores from the Ontong-Java plateau

    International Nuclear Information System (INIS)

    Five box cores, 30-35 cm deep, from the Ontong-Java Plateau in the Pacific Ocean have been analysed for several radioisotopes, bringing the total number of cores thus studied to nine. All cores contain calcareous sediments; they are from water depths between 1600 and 4300 m. The studies were made with a view to measure CaCO3 accumulation rates in the equatorial Pacific and to understand the nature of bioturbation and of erosion effects on carbonate accumulation. The 14C based accumulation rates vary from between 0.7 and 3 cm/k yr. The upper-most disturbed layer in the cores showing distinct effects of surface processes, including benthic mixing, is between 4 and 10 cm thick, in good agreement with the mean values for mixed layer thicknesses of 8 +- 2 cm reported earlier. The nature of mixing is very complicated. It does not resemble diffusion; considerable mixing seems to have occurred due to discrete events. The effects of in-situ dissolution during Holocene accumulation are clearly seen in two cores taken below 4000m. (auth.)

  5. CONDUCTING AND ANALYZING THE RESULTS OF THE EXPERIMENTAL BOX TEST OF RETAINING WALL MODELS WITHOUT PILES AND ON THE PILE FOUNDATION

    Directory of Open Access Journals (Sweden)

    M. A. Lisnevskyi

    2015-08-01

    Full Text Available Purpose. Taking into consideration that the bearing capacity of the foundation may be insufficient, in the study it is assumed that pile foundation can be used to reduce the impact of the construction of new retaining structures on roads and railways near the existing buildings or in areas of dense urban development and ensure the stability of the foundation. To reduce the volume of excavation it is necessary to choose the economic structure of the retaining wall. To do this, one should explore stress-strain state (SSS of the retaining walls, to develop methods to improve their strength and stability, as well as to choose the most appropriate method of their analysis. Methodology. In the design of retaining walls foundation mat and piles are considered as independent elements. Since the combined effect of the retaining wall, piles and foundation mat as well as the effect of soil or rock foundation on the structure are considered not fully, so there are some limitations in the existing design techniques. To achieve the purpose the box tests of retaining walls models without piles and with piles for studying their interaction with the surrounding soil massif were conducted. Findings. Laboratory simulation of complex systems «surrounding soil – retaining wall – pile» was carried out and on the basis of the box test results were analyzed strains and its main parameters of the stress-strain state. Analysis of the results showed that the structure of a retaining wall with piles is steady and stable. Originality. So far, in Ukraine has not been carried out similar experimental box tests with models of retaining walls in such combinations. In the article has been presented unique photos and test results, as well as their analysis. Practical value. Using the methodology of experimental tests of the retaining wall models with piles and without them gives a wider opportunity to study stress-strain state of such structures.

  6. Box-Behnken design in modeling of solid-phase tea waste extraction for the removal of uranium from water samples

    International Nuclear Information System (INIS)

    In this study, the solid-phase tea waste procedure was used for separation, preconcentration and determination of uranium from water samples by UV-Vis spectrophotometer. In addition, Box-Behnken experimental design was employed to investigated the influence of six variables including pH, mass of adsorbent, eluent volume, amount of 1-(2-pyridylazo)-2-naphthol (PAN); and sample and eluent flow rates on the extraction of analyte. High determination coefficient (R2) of 0.972 and adjusted-R2 of 0.943 showed the satisfactory adjustment of the polynomial regression model. This method was used for the extraction of uranium from real water samples.

  7. Einstein's Boxes

    CERN Document Server

    Norsen, T

    2005-01-01

    At the 1927 Solvay conference, Einstein presented a thought experiment intended to demonstrate the incompleteness of the quantum mechanical description of reality. In the following years, the thought experiment was picked up and modified by Einstein, de Broglie, and several other commentators into a simple scenario involving the splitting in half of the wave function of a single particle in a box. In this paper we collect together several formulations of this thought experiment from the existing literature; analyze and assess it from the point of view of the Einstein-Bohr debates, the EPR dilemma, and Bell's theorem; and generally lobby for Einstein's Boxes taking its rightful place alongside similar but historically better-known quantum mechanical thought experiments such as EPR and Schroedinger's Cat.

  8. Einstein's Boxes

    OpenAIRE

    Norsen, Travis

    2004-01-01

    At the 1927 Solvay conference, Einstein presented a thought experiment intended to demonstrate the incompleteness of the quantum mechanical description of reality. In the following years, the thought experiment was picked up and modified by Einstein, de Broglie, and several other commentators into a simple scenario involving the splitting in half of the wave function of a single particle in a box. In this paper we collect together several formulations of this thought experiment from the exist...

  9. Evidence summaries (decision boxes) to prepare clinicians for shared decision-making with patients: a mixed methods implementation study

    OpenAIRE

    Giguere, Anik MC; Labrecque, Michel; Haynes, R. Brian; Grad, Roland; Pluye, Pierre; Légaré, France; Cauchon, Michel; Greenway, Matthew; Carmichael, Pierre-Hugues

    2014-01-01

    Background Decision boxes (Dboxes) provide clinicians with research evidence about management options for medical questions that have no single best answer. Dboxes fulfil a need for rapid clinical training tools to prepare clinicians for clinician-patient communication and shared decision-making. We studied the barriers and facilitators to using the Dbox information in clinical practice. Methods We used a mixed methods study with sequential explanatory design. We recruited family physicians, ...

  10. A multiscale finite element model validation method of composite cable-stayed bridge based on Probability Box theory

    Science.gov (United States)

    Zhong, Rumian; Zong, Zhouhong; Niu, Jie; Liu, Qiqi; Zheng, Peijuan

    2016-05-01

    Modeling and simulation are routinely implemented to predict the behavior of complex structures. These tools powerfully unite theoretical foundations, numerical models and experimental data which include associated uncertainties and errors. A new methodology for multi-scale finite element (FE) model validation is proposed in this paper. The method is based on two-step updating method, a novel approach to obtain coupling parameters in the gluing sub-regions of a multi-scale FE model, and upon Probability Box (P-box) theory that can provide a lower and upper bound for the purpose of quantifying and transmitting the uncertainty of structural parameters. The structural health monitoring data of Guanhe Bridge, a composite cable-stayed bridge with large span, and Monte Carlo simulation were used to verify the proposed method. The results show satisfactory accuracy, as the overlap ratio index of each modal frequency is over 89% without the average absolute value of relative errors, and the CDF of normal distribution has a good coincidence with measured frequencies of Guanhe Bridge. The validated multiscale FE model may be further used in structural damage prognosis and safety prognosis.

  11. Response surface modeling of Pb(II) removal from aqueous solution by Pistacia vera L.: Box-Behnken experimental design.

    Science.gov (United States)

    Yetilmezsoy, Kaan; Demirel, Sevgi; Vanderbei, Robert J

    2009-11-15

    A three factor, three-level Box-Behnken experimental design combining with response surface modeling (RSM) and quadratic programming (QP) was employed for maximizing Pb(II) removal from aqueous solution by Antep pistachio (Pistacia vera L.) shells based on 17 different experimental data obtained in a lab-scale batch study. Three independent variables (initial pH of solution (pH(0)) ranging from 2.0 to 5.5, initial concentration of Pb(II) ions (C(0)) ranging from 5 to 50 ppm, and contact time (t(C)) ranging from 5 to 120 min) were consecutively coded as x(1), x(2) and x(3) at three levels (-1, 0 and 1), and a second-order polynomial regression equation was then derived to predict responses. The significance of independent variables and their interactions were tested by means of the analysis of variance (ANOVA) with 95% confidence limits (alpha=0.05). The standardized effects of the independent variables and their interactions on the dependent variable were also investigated by preparing a Pareto chart. The optimum values of the selected variables were obtained by solving the quadratic regression model, as well as by analysing the response surface contour plots. The optimum coded values of three test variables were computed as x(1)=0.125, x(2)=0.707, and x(3)=0.107 by using a LOQO/AMPL optimization algorithm. The experimental conditions at this global point were determined to be pH(0)=3.97, C(0)=43.4 ppm, and t(C)=68.7 min, and the corresponding Pb(II) removal efficiency was found to be about 100%. PMID:19577844

  12. Using the intervention mapping protocol to reduce European preschoolers' sedentary behavior, an application to the ToyBox-Study

    OpenAIRE

    De Decker, Ellen; De Craemer, Marieke; De Bourdeaudhuij, Ilse; Verbestel, Vera; Duvinage, Kristin; Iotova, Violeta; Grammatikaki, Evangelia; Wildgruber, Andreas; Mouratidou, Theodora; Manios, Yannis; Cardon, Greet

    2014-01-01

    Background: High levels of sedentary behavior are often measured in preschoolers, but only a few interventions have been developed to counteract this. Furthermore, detailed descriptions of interventions in preschoolers targeting different forms of sedentary behavior could not be located in the literature. The aim of the present paper was to describe the different steps of the Intervention Mapping Protocol used towards the development of an intervention component of the ToyBox-study focusing o...

  13. Opening the Black Box of Clinical Collaboration in Integrated Care Models for Frail, Elderly Patients

    Science.gov (United States)

    de Stampa, Matthieu; Vedel, Isabelle; Bergman, Howard; Novella, Jean-Luc; Lechowski, Laurent; Ankri, Joel; Lapointe, Liette

    2013-01-01

    Purpose: The purpose of the study was to understand better the clinical collaboration process among primary care physicians (PCPs), case managers (CMs), and geriatricians in integrated models of care. Methods: We conducted a qualitative study with semistructured interviews. A purposive sample of 35 PCPs, 7 CMs, and 4 geriatricians was selected in…

  14. Application of a dynamical two-box surface-atmosphere model to the Mount Pinatubo cooling event

    CERN Document Server

    Knox, Robert S

    2008-01-01

    We analyze the global temperature change due to the Mt. Pinatubo eruption using a simple two-layer model of the atmosphere and surface to obtain results consistent with satellite data. Current highly complex models exist to model this and other temperature anomalies, but because of their complexity are not easily analyzed by those not directly involved. Through analytic and numerical analysis we find a principal characteristic response time of 5 to 8 months and a climate sensitivity of 0.17 to 0.20 C/(W/m^2), corresponding to a negative instantaneous feedback. Our solutions were fit to the data, reproducing the results of a one-box model, and providing somewhat more detailed information about the feedbacks related to surface layer temperature. The formalism for coupling of the surface layer to the thermocline is set up but not applied.

  15. Simple Statistical Model to Quantify Maximum Expected EMC in Spacecraft and Avionics Boxes

    Science.gov (United States)

    Trout, Dawn H.; Bremner, Paul

    2014-01-01

    This study shows cumulative distribution function (CDF) comparisons of composite a fairing electromagnetic field data obtained by computational electromagnetic 3D full wave modeling and laboratory testing. Test and model data correlation is shown. In addition, this presentation shows application of the power balance and extention of this method to predict the variance and maximum exptected mean of the E-field data. This is valuable for large scale evaluations of transmission inside cavities.

  16. Spinal high-mobility group box 1 contributes to mechanical allodynia in a rat model of bone cancer pain

    International Nuclear Information System (INIS)

    Mechanisms underlying bone cancer-induced pain are largely unknown. Previous studies indicate that neuroinflammation in the spinal dorsal horn is especially involved. Being first reported as a nonhistone chromosomal protein, high-mobility group box 1 (HMGB1) is now implicated as a mediator of inflammation. We hypothesized that HMGB1 could trigger the release of cytokines in the spinal dorsal horn and contribute to bone cancer pain. To test this hypothesis, we first built a bone cancer pain model induced by intratibal injection of Walker 256 mammary gland carcinoma cells. The structural damage to the tibia was monitored by radiological analysis. The mechanical allodynia was measured and the expression of spinal HMGB1 and IL-1β was evaluated. We observed that inoculation of cancer cells, but not heat-killed cells, induced progressive bone destruction from 9 d to 21 d post inoculation. Behavioral tests demonstrated that the significant nociceptive response in the cancer cells-injected rats emerged on day 9 and this kind of mechanical allodynia lasted at least 21 d following inoculation. Tumor cells inoculation significantly increased HMGB1 expression in the spinal dorsal horn, while intrathecal injecting a neutralizing antibody against HMGB1 showed an effective and reliable anti-allodynia effect with a dose-dependent manner. IL-1β was significantly increased in caner pain rats while intrathecally administration of anti-HMGB1 could decrease IL-1β. Together with previous reports, we predict that bone cancer induces HMGB1 production, enhancing spinal IL-1β expression and thus modulating spinal excitatory synaptic transmission and pain response.

  17. Differences in Energy Balance-Related Behaviours in European Preschool Children: The ToyBox-Study

    Science.gov (United States)

    De Craemer, Marieke; Lateva, Mina; Iotova, Violeta; De Decker, Ellen; Verloigne, Maïté; De Bourdeaudhuij, Ilse; Androutsos, Odysseas; Socha, Piotr; Kulaga, Zbigniew; Moreno, Luis; Koletzko, Berthold; Manios, Yannis; Cardon, Greet

    2015-01-01

    Background The aim of the current study was to compare levels of energy balance-related behaviours (physical activity, sedentary behaviour, and dietary behaviours (more specifically water consumption, sugar-sweetened beverage consumption and unhealthy snacking)) in four- to six-year-old preschoolers from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, and Spain) within the ToyBox cross-sectional study. Methods A sample of 4,045 preschoolers (4.77 ± 0.43 years; 52.2% boys) had valid physical activity data (steps per day), parents of 8,117 preschoolers (4.78 ± 0.46 years; 53.0% boys) completed a parental questionnaire with questions on sedentary behaviours (television viewing, computer use, and quiet play), and parents of 7,244 preschoolers (4.77 ± 0.44 years; 52.0% boys) completed a food frequency questionnaire with questions on water consumption, sugar-sweetened beverage consumption and unhealthy snacking. Results The highest levels of physical activity were found in Spain (12,669 steps/day on weekdays), while the lowest levels were found in Bulgaria and Greece (9,777 and 9,656 steps/day on weekdays, respectively). German preschoolers spent the least amount of time in television viewing (43.3 min/day on weekdays), while Greek preschoolers spent the most time in television viewing (88.5 min/day on weekdays). A considerable amount of time was spent in quiet play in all countries, with the highest levels in Poland (104.9 min/day on weekdays), and the lowest levels in Spain (60.4 min/day on weekdays). Belgian, German, and Polish preschoolers had the lowest intakes of water and the highest intakes of sugar-sweetened beverages. The intake of snacks was the highest in Belgian preschoolers (73.1 g/day) and the lowest in Greek preschoolers (53.3 g/day). Conclusions Across six European countries, differences in preschoolers’ energy balance-related behaviours were found. Future interventions should target European preschoolers’ energy balance

  18. Differences in energy balance-related behaviours in European preschool children: the ToyBox-study.

    Directory of Open Access Journals (Sweden)

    Marieke De Craemer

    Full Text Available The aim of the current study was to compare levels of energy balance-related behaviours (physical activity, sedentary behaviour, and dietary behaviours (more specifically water consumption, sugar-sweetened beverage consumption and unhealthy snacking in four- to six-year-old preschoolers from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, and Spain within the ToyBox cross-sectional study.A sample of 4,045 preschoolers (4.77 ± 0.43 years; 52.2% boys had valid physical activity data (steps per day, parents of 8,117 preschoolers (4.78 ± 0.46 years; 53.0% boys completed a parental questionnaire with questions on sedentary behaviours (television viewing, computer use, and quiet play, and parents of 7,244 preschoolers (4.77 ± 0.44 years; 52.0% boys completed a food frequency questionnaire with questions on water consumption, sugar-sweetened beverage consumption and unhealthy snacking.The highest levels of physical activity were found in Spain (12,669 steps/day on weekdays, while the lowest levels were found in Bulgaria and Greece (9,777 and 9,656 steps/day on weekdays, respectively. German preschoolers spent the least amount of time in television viewing (43.3 min/day on weekdays, while Greek preschoolers spent the most time in television viewing (88.5 min/day on weekdays. A considerable amount of time was spent in quiet play in all countries, with the highest levels in Poland (104.9 min/day on weekdays, and the lowest levels in Spain (60.4 min/day on weekdays. Belgian, German, and Polish preschoolers had the lowest intakes of water and the highest intakes of sugar-sweetened beverages. The intake of snacks was the highest in Belgian preschoolers (73.1 g/day and the lowest in Greek preschoolers (53.3 g/day.Across six European countries, differences in preschoolers' energy balance-related behaviours were found. Future interventions should target European preschoolers' energy balance-related behaviours simultaneously, but should

  19. Box and Gaussian plume models of the exhaust composition evolution of subsonic transport aircraft in- and out of the flight corridor

    Directory of Open Access Journals (Sweden)

    I. L. Karol

    Full Text Available A box and a Gaussian plume model including gas-phase photochemistry and with plume dispersion parameters estimated from the few available plume observations are proposed and used for evaluation of photochemical transformations of exhausts from a single subsonic transport aircraft. The effects of concentration inhomogeneities in the plume cross section on the photochemical sources and sinks in the plume are analyzed for various groups of compounds. The influence of these inhomogeneities on the rate and on the mass of ambient air entrainment into the plume are studied also by comparing the box and the Gaussian plume model simulations during the first hours of their "life''. Due to the enterance of HOx and NOx from ambient air into the plume with rates varying from the wind shear and turbulence conditions, the rate of emitted NOx oxidation in the plume is dependent on these and also on the background concentration levels of HOx and NOx.

  20. Box-Behnken Design Application to Study Leaching of Pyrolusite from Manganese Mining Residue Using Olive Mill Wastewater as Reductant

    Science.gov (United States)

    Alaoui, Abdallah; El Kacemi, K.; El Ass, K.; Kitane, S.; El Bouzidi, S.

    2015-05-01

    The leaching capacity of olive mill wastewater (OMW) for pyrolusite mine tailings (MnO2) was evaluated using the Box-Behnken experimental design of response surface methodology. The selected test parameters include the concentration of sulfuric acid, the OMW dosage chemical oxygen demand (COD), the solid/liquid ratio S/ L, and particle size. It was determined that the MnO2 dissolution increased with an increase in the sulfuric acid concentration and the OMW dosage, and with a decrease in the solid/liquid ratio. The particle size does not have significant influence on the manganese recovery. A quadratic polynomial model has been developed to predict the amount of manganese extraction from pyrolusite for other operating conditions that were not directly tested. The leaching ability was evaluated based on manganese recovery (Mn%) and the removal capability of chemical oxygen demand (COD%). The predicted values for the responses agreed well with experimental values; R 2 (correlation coefficient) values for Mn% and COD% were 0.9602 and 0.9687, respectively. Within the design space, the optimum conditions for the lixiviation of MnO2 in terms of manganese recovery and COD removal were established and include [H2SO4] of 3 mol L-1, OMW in range of 23 g L-1 to 25 g L-1 COD, and pulp density in range of 90 g L-1 to 100 g L-1. Under these conditions, the response values generated by the model are Mn% ˜49% and COD% >40%. These values show good agreement with those obtained in the validation test. This study has demonstrated that it is possible to use the olive mill wastewater as a reductant agent to recover manganese from a pyrolusite mining residue.

  1. Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1 and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.

    Directory of Open Access Journals (Sweden)

    Oscar Rodríguez-Lima

    Full Text Available TATA-box binding protein (TBP is an essential regulatory transcription factor for the TATA-box and TATA-box-less gene promoters. We report the cloning and characterization of a full-length cDNA that encodes a Taenia solium TATA-box binding protein 1 (TsTBP1. Deduced amino acid composition from its nucleotide sequence revealed that encodes a protein of 238 residues with a predicted molecular weight of 26.7 kDa, and a theoretical pI of 10.6. The NH2-terminal domain shows no conservation when compared with to pig and human TBP1s. However, it shows high conservation in size and amino acid identity with taeniids TBP1s. In contrast, the TsTBP1 COOH-terminal domain is highly conserved among organisms, and contains the amino acids involved in interactions with the TATA-box, as well as with TFIIA and TFIIB. In silico TsTBP1 modeling reveals that the COOH-terminal domain forms the classical saddle structure of the TBP family, with one α-helix at the end, not present in pig and human. Native TsTBP1 was detected in T. solium cysticerci´s nuclear extract by western blot using rabbit antibodies generated against two synthetic peptides located in the NH2 and COOH-terminal domains of TsTBP1. These antibodies, through immunofluorescence technique, identified the TBP1 in the nucleus of cells that form the bladder wall of cysticerci of Taenia crassiceps, an organism close related to T. solium. Electrophoretic mobility shift assays using nuclear extracts from T. solium cysticerci and antibodies against the NH2-terminal domain of TsTBP1 showed the interaction of native TsTBP1 with the TATA-box present in T. solium actin 5 (pAT5 and 2-Cys peroxiredoxin (Ts2-CysPrx gene promoters; in contrast, when antibodies against the anti-COOH-terminal domain of TsTBP1 were used, they inhibited the binding of TsTBP1 to the TATA-box of the pAT5 promoter gene.

  2. Molecular Cloning of a cDNA Encoding for Taenia solium TATA-Box Binding Protein 1 (TsTBP1) and Study of Its Interactions with the TATA-Box of Actin 5 and Typical 2-Cys Peroxiredoxin Genes.

    Science.gov (United States)

    Rodríguez-Lima, Oscar; García-Gutierrez, Ponciano; Jiménez, Lucía; Zarain-Herzberg, Ángel; Lazzarini, Roberto; Landa, Abraham

    2015-01-01

    TATA-box binding protein (TBP) is an essential regulatory transcription factor for the TATA-box and TATA-box-less gene promoters. We report the cloning and characterization of a full-length cDNA that encodes a Taenia solium TATA-box binding protein 1 (TsTBP1). Deduced amino acid composition from its nucleotide sequence revealed that encodes a protein of 238 residues with a predicted molecular weight of 26.7 kDa, and a theoretical pI of 10.6. The NH2-terminal domain shows no conservation when compared with to pig and human TBP1s. However, it shows high conservation in size and amino acid identity with taeniids TBP1s. In contrast, the TsTBP1 COOH-terminal domain is highly conserved among organisms, and contains the amino acids involved in interactions with the TATA-box, as well as with TFIIA and TFIIB. In silico TsTBP1 modeling reveals that the COOH-terminal domain forms the classical saddle structure of the TBP family, with one α-helix at the end, not present in pig and human. Native TsTBP1 was detected in T. solium cysticerci´s nuclear extract by western blot using rabbit antibodies generated against two synthetic peptides located in the NH2 and COOH-terminal domains of TsTBP1. These antibodies, through immunofluorescence technique, identified the TBP1 in the nucleus of cells that form the bladder wall of cysticerci of Taenia crassiceps, an organism close related to T. solium. Electrophoretic mobility shift assays using nuclear extracts from T. solium cysticerci and antibodies against the NH2-terminal domain of TsTBP1 showed the interaction of native TsTBP1 with the TATA-box present in T. solium actin 5 (pAT5) and 2-Cys peroxiredoxin (Ts2-CysPrx) gene promoters; in contrast, when antibodies against the anti-COOH-terminal domain of TsTBP1 were used, they inhibited the binding of TsTBP1 to the TATA-box of the pAT5 promoter gene. PMID:26529408

  3. Algorithms for Probabilistically-Constrained Models of Risk-Averse Stochastic Optimization with Black-Box Distributions

    CERN Document Server

    Swamy, Chaitanya

    2008-01-01

    We consider various stochastic models that incorporate the notion of risk-averseness into the standard 2-stage recourse model, and develop novel techniques for solving the algorithmic problems arising in these models. A key notable feature of our work that distinguishes it from work in some other related models, such as the (standard) budget model and the (demand-) robust model, is that we obtain results in the black-box setting, that is, where one is given only sampling access to the underlying distribution. Our first model, which we call the risk-averse budget model, incorporates the notion of risk-averseness via a probabilistic constraint that restricts the probability (according to the underlying distribution) with which the second-stage cost may exceed a given budget B to at most a given input threshold \\rho. We also a consider a closely-related model that we call the risk-averse robust model, where we seek to minimize the first-stage cost and the (1-\\rho)-quantile of the second-stage cost. We obtain app...

  4. A grey box model of glucose fermentation and syntrophic oxidation in microbial fuel cells.

    Science.gov (United States)

    de Los Ángeles Fernandez, Maria; de Los Ángeles Sanromán, Maria; Marks, Stanislaw; Makinia, Jacek; Gonzalez Del Campo, Araceli; Rodrigo, Manuel; Fernandez, Francisco Jesus

    2016-01-01

    In this work, the fermentative and oxidative processes taking place in a microbial fuel cell (MFC) fed with glucose were studied and modeled. The model accounting for the bioelectrochemical processes was based on ordinary, Monod-type differential equations. The model parameters were estimated using experimental results obtained from three H-type MFCs operated at open or closed circuits and fed with glucose or ethanol. The experimental results demonstrate that similar fermentation processes were carried out under open and closed circuit operation, with the most important fermentation products being ethanol (with a yield of 1.81molmol(-1) glucose) and lactic acid (with a yield of 1.36molmol(-1) glucose). A peak in the electricity generation was obtained when glucose and fermentation products coexisted in the liquid bulk. However, almost 90% of the electricity produced came from the oxidation of ethanol. PMID:26512864

  5. NewsPaperBox - Online News Space: a visual model for representing the social space of a website

    Directory of Open Access Journals (Sweden)

    Selçuk Artut

    2010-02-01

    Full Text Available NewsPaperBox * propounds an alternative visual model utilizing the treemap algorithm to represent the collective use of a website that evolves in response to user interaction. While the technology currently exists to track various user behaviors such as number of clicks, duration of stay on a given web site, these statistics are not yet employed to influence the visual representation of that site's design in real time. In that sense, this project propounds an alternative modeling of a representational outlook of a website that is developed by collaborations and competitions of its global users. This paper proposes the experience of cyberspace as a generative process driven by its effective user participation.

  6. Teaching with Box Tops.

    Science.gov (United States)

    Raiser, Lynne; D'Zamko, Mary Elizabeth

    1984-01-01

    Using environmental materials (such as the phone book and placemats from fast food restaurants) can be a motivating way to teach learning disabled students skills and concepts, as shown in an approach to reading, math, science and nutrition, and social studies instruction using a JELL-O brand gelatin box. (CL)

  7. Effect and Process Evaluation of a Cluster Randomized Control Trial on Water Intake and Beverage Consumption in Preschoolers from Six European Countries: The ToyBox-Study

    OpenAIRE

    Pinket, An-Sofie; Van Lippevelde, Wendy; De Bourdeaudhuij, Ilse; Deforche, Benedicte; Cardon, Greet; Androutsos, Odysseas; Koletzko, Berthold; Luis A. Moreno; Socha, Piotr; Iotova, Violeta; Manios, Yannis; De Craemer, Marieke; ,

    2016-01-01

    Background Within the ToyBox-study, a kindergarten-based, family-involved intervention was developed to prevent overweight and obesity in European preschoolers, targeting four key behaviours related to early childhood obesity, including water consumption. The present study aimed to examine the effect of the ToyBox-intervention (cluster randomized controlled trial) on water intake and beverage consumption in European preschoolers and to investigate if the intervention effects differed by imple...

  8. Effect and process evaluation of a cluster randomized control trial on water intake and beverage consumption in preschoolers from six European countries: the ToyBox-study

    OpenAIRE

    Pinket, An-Sofie; Van Lippevelde, Wendy; De Bourdeaudhuij, Ilse; Deforche, Benedicte; Cardon, Greet; Androutsos, Odysseas; Koletzko, Berthold; Luis A. Moreno; Socha, Piotr; Iotova, Violeta; Manios, Yannis; De Craemer, Marieke

    2016-01-01

    BACKGROUND: Within the ToyBox-study, a kindergarten-based, family-involved intervention was developed to prevent overweight and obesity in European preschoolers, targeting four key behaviours related to early childhood obesity, including water consumption. The present study aimed to examine the effect of the ToyBox-intervention (cluster randomized controlled trial) on water intake and beverage consumption in European preschoolers and to investigate if the intervention effects differed by impl...

  9. Opening the Black Box: Using a Hydrological Model to Link Stakeholder Engagement with Groundwater Management

    Directory of Open Access Journals (Sweden)

    Susanna Eden

    2016-05-01

    Full Text Available Stakeholder participation is a foundation of good water governance. Good groundwater governance typically involves the co-production of knowledge about the groundwater system. Models provide a vehicle for producing this knowledge, as well as a “boundary object” around which scientists and stakeholders can convene the co-production process. Through co-production, stakeholders and scientific experts can engage in exchanges that create system knowledge not otherwise achievable. The process involves one-way transfer of information, active two-way conversations, and integration of multiple kinds of knowledge into shared understanding. In the Upper Santa Cruz River basin in Arizona, USA, the University of Arizona Water Resources Research Center (WRRC convened a project aimed at providing scientific underpinnings for groundwater planning and management. This project, entitled Groundwater, Climate, and Stakeholder Engagement, serves as a case study employing the first two stages of knowledge co-production using a hydrological model. Through an iterative process that included two-way communication, stakeholders provided critical input to hydrologic modeling analyses. Acting as a bridging organization, the WRRC facilitated a co-production process, involving location-specific and transferability workshops, which resulted in new knowledge and capacity for applying the model to novel problems.

  10. A dynamic box model to predict the radionuclide behaviour in river for average and long-term periods

    International Nuclear Information System (INIS)

    This paper presents a dynamic box model to predict, for average and long time periods, the radionuclide behaviour in the main abiotic and biotic compartments of rivers. It is integrated in the operational code CASTEAUR, aiming to increase its application domain, limited, up to now, to short-term periods. The retained approach for this tool describes the river as a succession of elementary boxes representative of its different reaches. Two media are considered, the water column and the bottom sediment, through their biotic and abiotic components. In the water column, the abiotic components are the water and different classes of suspended particles classified according their deposit kinetics. The biotic components are plankton, divided into phytoplankton and zooplankton, and fish, distributed in planktonivorous and omnivorous species. The bottom sediment is represented according two layers. The first one, which can exchange with the water column, is called the reactive layer. Its abiotic components are the interstitial water and the different classes of deposit matter. It also includes a biotic component called macro-benthos. The second layer, i.e. the permanent layer, contains only the different classes of deposit matter transferred from the previous layer by consolidation process. The main processes linking all these components are modelled to assess in each reach the average radionuclide concentrations in the abiotic and biotic targets (components) describing the river ecosystem. The calculation are made with a minimum daily time step and for periods from several days to several years, taken possibly into account several releases distributed in time and space, and characterized by daily kinetics. After the model, an application on a real case is presented. (author)

  11. Numerical Weather Prediction Models on Linux Boxes as tools in meteorological education in Hungary

    Science.gov (United States)

    Gyongyosi, A. Z.; Andre, K.; Salavec, P.; Horanyi, A.; Szepszo, G.; Mille, M.; Tasnadi, P.; Weidiger, T.

    2012-04-01

    Education of Meteorologist in Hungary - according to the Bologna Process - has three stages: BSc, MSc and PhD, and students graduating at each stage get the respective degree (BSc, MSc and PhD). The three year long base BSc course in Meteorology can be chosen by undergraduate students in the fields of Geosciences, Environmental Sciences and Physics. BasicsFundamentals in Mathematics (Calculus), Physics (General and Theoretical) Physics and Informatics are emphasized during their elementary education. The two year long MSc course - in which about 15 to 25 students are admitted each year - can be studied only at our the Eötvös Loránd uUniversity in the our country. Our aim is to give a basic education in all fields of Meteorology. Main topics are: Climatology, Atmospheric Physics, Atmospheric Chemistry, Dynamic and Synoptic Meteorology, Numerical Weather Prediction, modeling Modeling of surfaceSurface-atmosphere Iinteractions and Cclimate change. Education is performed in two branches: Climate Researcher and Forecaster. Education of Meteorologist in Hungary - according to the Bologna Process - has three stages: BSc, MSc and PhD, and students graduating at each stage get the respective degree. The three year long BSc course in Meteorology can be chosen by undergraduate students in the fields of Geosciences, Environmental Sciences and Physics. Fundamentals in Mathematics (Calculus), (General and Theoretical) Physics and Informatics are emphasized during their elementary education. The two year long MSc course - in which about 15 to 25 students are admitted each year - can be studied only at the Eötvös Loránd University in our country. Our aim is to give a basic education in all fields of Meteorology: Climatology, Atmospheric Physics, Atmospheric Chemistry, Dynamic and Synoptic Meteorology, Numerical Weather Prediction, Modeling of Surface-atmosphere Interactions and Climate change. Education is performed in two branches: Climate Researcher and Forecaster

  12. SimpleTreat: a spreadsheet-based box model to predict the fate of xenobiotics in a municipal waste water treatment plant

    NARCIS (Netherlands)

    Struijs J; van de Meent D; Stoltenkamp J

    1991-01-01

    A non-equilibrium steady state box model is reported, that predicts the fate of new chemicals in a conventional sewage treatment plant from a minimal input data set. The model, written in an electronic spreadsheet (Lotus TM 123), requires a minimum input: some basic properties of the chemical, its

  13. The BOXES Methodology Black Box Dynamic Control

    CERN Document Server

    Russell, David W

    2012-01-01

    Robust control mechanisms customarily require knowledge of the system’s describing equations which may be of the high order differential type.  In order to produce these equations, mathematical models can often be derived and correlated with measured dynamic behavior.  There are two flaws in this approach one is the level of inexactness introduced by linearizations and the other when no model is apparent.  Several years ago a new genre of control systems came to light that are much less dependent on differential models such as fuzzy logic and genetic algorithms. Both of these soft computing solutions require quite considerable a priori system knowledge to create a control scheme and sometimes complicated training program before they can be implemented in a real world dynamic system. Michie and Chambers’ BOXES methodology created a black box system that was designed to control a mechanically unstable system with very little a priori system knowledge, linearization or approximation.  All the method need...

  14. Bending analysis of laminated composite box beams

    Energy Technology Data Exchange (ETDEWEB)

    Tripathy, A.K.; Patel, H.J.; Pang, S.S. (Louisiana State Univ., Baton Rouge, LA (United States). Dept. of Mechanical Engineering)

    1994-01-01

    Box beams are widely used in weight reduction structures such as aircraft wings. The use of composite box beams further reduces the weight factor for such structures with the same deflection and stress as that of isotropic box beams. The difference in the behavior of composite box beam with different fiber orientation, number of plies, and number of stringers also provides a wide range of designing parameters to achieve the required performance for a given problem. A bending analysis has been carried out for the study of deflections and stresses for box beams of different material (isotropic and laminated composites), size, and number of stringers subjected to different kinds of loading conditions. A finite element model has been developed based on the strain energy principle, and the results are compared with an available commercial code COSMOS/M.'' Experiments using aluminum and scotchply composite laminates were conducted to verify the results. An optimal design for size and number of stiffeners for a given loading condition has been achieved. Investigations have also been carried out to find the effect of transverse shear on the span-wise normal stress.

  15. Gray-box model for energy-efficient selection of set point hysteresis in heating, ventilation, air conditioning, and refrigeration controllers

    International Nuclear Information System (INIS)

    Highlights: • A gray-box model is proposed for energy-efficient selection of on/off set points. • Exponential temperature correlations are identified based on measurements. • Air conditioning set points are designed to achieve the highest energy efficiency. • Design constraints on compressor and room temperature are considered in the model. • Average cooling power and temperature are estimated for any set point pair. - Abstract: Many heating, ventilation, air conditioning, and refrigeration systems operate using on/off controllers. A high and a low set point are selected above and below the desired temperature to command the refrigeration cycle to turn on or off when those temperatures are reached. In this study, exponential temperature correlations are used in a gray-box approach to provide information about the estimated mean temperature, average power consumption, and number of compressor starts per hour. Based on the governing equations and the heat balance of the system, a set of formulations is developed as a new analytical tool for the design of set points. It is discussed that for any specific application, the set point values can be properly selected to minimize the overall energy consumption subject to the design constraints. It is shown through an experimental study that the selection of the set points can affect the overall energy consumption by up to 49% for the same desired temperature. It is also shown that there is a further opportunity for increasing the energy efficiency by 6.6% using different high and low set point hysteresis values. The developed model can be used for designing and analyzing new systems. It can also be used for retrofitting existing units and achieving the highest energy efficiency subject to the design constraints

  16. The effect of plasma actuator on the depreciation of the aerodynamic drag on box model

    Science.gov (United States)

    Harinaldi, Budiarso, Julian, James; Rabbani M., N.

    2016-06-01

    Recent active control research advances have provided many benefits some of which in the field of transportation by land, sea as well as by air. Flow engineering by using active control has proven advantages in energy saving significantly. One of the active control equipment that is being developed, especially in the 21st century, is a plasma actuator, with the ability to modify the flow of fluid by the approach of ion particles makes these actuators a very powerful and promising tool. This actuator can be said to be better to the previously active control such as suction, blowing and synthetic jets because it is easier to control, more flexible because it has no moving parts, easy to be manufactured and installed, and consumes a small amount of energy with maximum capability. Plasma actuator itself is the composition of a material composed of copper and a dielectric sheet, where the copper sheets act as an electricity conductor and the dielectric sheet as electricity insulator. Products from the plasma actuators are ion wind which is the result of the suction of free air around the actuator to the plasma zone. This study investigates the ability of plasma actuators in lowering aerodynamic drag which is commonly formed in the models of vehicles by varying the shape of geometry models and the flow speed.

  17. Analysis of a genetically structured variance heterogeneity model using the Box-Cox transformation

    DEFF Research Database (Denmark)

    Yang, Ye; Christensen, Ole Fredslund; Sorensen, Daniel

    2011-01-01

    of the marginal distribution of the data. To investigate how the scale of measurement affects inferences, the genetically structured heterogeneous variance model is extended to accommodate the family of Box–Cox transformations. Litter size data in rabbits and pigs that had previously been analysed in...... the untransformed scale were reanalysed in a scale equal to the mode of the marginal posterior distribution of the Box–Cox parameter. In the rabbit data, the statistical evidence for a genetic component at the level of the environmental variance is considerably weaker than that resulting from an...... analysis in the original metric. In the pig data, the statistical evidence is stronger, but the coefficient of correlation between additive genetic effects affecting mean and variance changes sign, compared to the results in the untransformed scale. The study confirms that inferences on variances can be...

  18. Box-Behnken design in modeling of solid-phase tea waste extraction for the removal of uranium from water samples

    Energy Technology Data Exchange (ETDEWEB)

    Khajeh, Mostafa; Jahanbin, Elham; Ghaffari-Moghaddam, Mansour; Moghaddam, Zahra Safaei [Zabol Univ. (Iran, Islamic Republic of). Dept. of Chemistry; Bohlooli, Mousa [Zabol Univ. (Iran, Islamic Republic of). Dept. of Biology

    2015-07-01

    In this study, the solid-phase tea waste procedure was used for separation, preconcentration and determination of uranium from water samples by UV-Vis spectrophotometer. In addition, Box-Behnken experimental design was employed to investigated the influence of six variables including pH, mass of adsorbent, eluent volume, amount of 1-(2-pyridylazo)-2-naphthol (PAN); and sample and eluent flow rates on the extraction of analyte. High determination coefficient (R{sup 2}) of 0.972 and adjusted-R{sup 2} of 0.943 showed the satisfactory adjustment of the polynomial regression model. This method was used for the extraction of uranium from real water samples.

  19. Identification of a nonlinear black-box model for a self-sensing polymer metal composite actuator

    International Nuclear Information System (INIS)

    An ion polymer metal composite (IPMC) is an electro-active polymer that bends in response to a small applied electrical field as a result of the mobility of cations in the polymer network and vice versa. The aim of this paper is the identification of a novel accurate nonlinear black-box model (NBBM) for IPMC actuators with self-sensing behavior based on a recurrent multi-layer perceptron neural network (RMLPNN) and a self-adjustable learning mechanism (SALM). Firstly, an IPMC actuator is investigated. Driving voltage signals are applied to the IPMC in order to identify the IPMC characteristics. Secondly, the advanced NBBM for the IPMC is built with suitable inputs and output to estimate the IPMC tip displacement. Finally, the model parameters are optimized by the collected input/output training data. Modeling results show that the proposed self-sensing methodology based on the optimized NBBM model can well describe the bending behavior of the IPMC actuator corresponding to its applied power without using any measuring sensor

  20. Inverse grey-box model-based control of a dielectric elastomer actuator

    DEFF Research Database (Denmark)

    Jones, Richard William; Sarban, Rahimullah

    2012-01-01

    An accurate physical-based electromechanical model of a commercially available tubular dielectric elastomer (DE) actuator has been developed and validated. In this contribution, the use of the physical-based electromechanical model to formulate a model-based controller is examined. The choice of...

  1. The Heuristic Interpretation of Box Plots

    Science.gov (United States)

    Lem, Stephanie; Onghena, Patrick; Verschaffel, Lieven; Van Dooren, Wim

    2013-01-01

    Box plots are frequently used, but are often misinterpreted by students. Especially the area of the box in box plots is often misinterpreted as representing number or proportion of observations, while it actually represents their density. In a first study, reaction time evidence was used to test whether heuristic reasoning underlies this…

  2. Analisis Transformasi Box Cox Untuk Mengatasi Heteroskedastisitas Dalam Model Regresi Linier Sederhana.

    OpenAIRE

    Desri Kristina S

    2011-01-01

    Regression analysis is one of statistic technics that used to determine the relation model of one respon variable (Y) with one or more independent variable (X), what is generally expressed in equation mathematic. In statistic, a regression model is obtained by estimate of its parameter by using certain method, one of them is with the Maximum Likelihood Methods. Regression model that obtained to be told is good or fit, if fulfilled by the ideal assumption (classic). One of linear regression as...

  3. Spray irrigation of landfill leachate: estimating potential exposures to workers and bystanders using a modified air box model and generalised source term

    International Nuclear Information System (INIS)

    Generalised source term data from UK leachates and a probabilistic exposure model (BPRISC4) were used to evaluate key routes of exposure from chemicals of concern during the spraying irrigation of landfill leachate. Risk estimates secured using a modified air box model are reported for a hypothetical worker exposed to selected chemicals within a generalised conceptual exposure model of spray irrigation. Consistent with pesticide spray exposure studies, the key risk driver is dermal exposure to the more toxic components of leachate. Changes in spray droplet diameter (0.02-0.2 cm) and in spray flow rate (50-1000 l/min) have little influence on dermal exposure, although the lesser routes of aerosol ingestion and inhalation are markedly affected. The risk estimates modelled using this conservative worst case exposure scenario are not of sufficient magnitude to warrant major concerns about chemical risks to workers or bystanders from this practice in the general sense. However, the modelling made use of generic concentration data for only a limited number of potential landfill leachate contaminants, such that individual practices may require assessment on the basis of their own merits. - Modelling approaches are used to assess human exposure routes to chemicals during spray irrigation of landfill leachates

  4. 基于系统辨识的地表太阳辐射Box-Jenkins模型的建立%ESTABLISHMENT OF BOX-JENKINS MODEL FOR SURFACE SOLAR RADIATION BASED ON SYSTEM IDENTIFICATION METHOD

    Institute of Scientific and Technical Information of China (English)

    王敏; 丁明

    2012-01-01

    Astronomical radiation as the input data, the BJ (Box-Jenkins) model for surface solar radiation was established using system identification method. The model was affirmed to be workable by residual analysis and zero-pole test. This method can be used to predict the surface solar radiation of 5 -15 minutes time interval, the prediction results can provide solar radiation data for power output forecast of solar PV power plants.%利用天文辐射作为输入数据,采用系统辨识的方法得到地表太阳辐射的BJ(Box-Jenkins)模型,并通过残 差分析和零极点检验.该方法可用于预测5~ 15min时间间隔的地表太阳辐射,为太阳能电站的功率输出预测提供太阳能辐射数据.

  5. NASA's Climate in a Box: Desktop Supercomputing for Open Scientific Model Development

    Science.gov (United States)

    Wojcik, G. S.; Seablom, M. S.; Lee, T. J.; McConaughy, G. R.; Syed, R.; Oloso, A.; Kemp, E. M.; Greenseid, J.; Smith, R.

    2009-12-01

    NASA's High Performance Computing Portfolio in cooperation with its Modeling, Analysis, and Prediction program intends to make its climate and earth science models more accessible to a larger community. A key goal of this effort is to open the model development and validation process to the scientific community at large such that a natural selection process is enabled and results in a more efficient scientific process. One obstacle to others using NASA models is the complexity of the models and the difficulty in learning how to use them. This situation applies not only to scientists who regularly use these models but also non-typical users who may want to use the models such as scientists from different domains, policy makers, and teachers. Another obstacle to the use of these models is that access to high performance computing (HPC) accounts, from which the models are implemented, can be restrictive with long wait times in job queues and delays caused by an arduous process of obtaining an account, especially for foreign nationals. This project explores the utility of using desktop supercomputers in providing a complete ready-to-use toolkit of climate research products to investigators and on demand access to an HPC system. One objective of this work is to pre-package NASA and NOAA models so that new users will not have to spend significant time porting the models. In addition, the prepackaged toolkit will include tools, such as workflow, visualization, social networking web sites, and analysis tools, to assist users in running the models and analyzing the data. The system architecture to be developed will allow for automatic code updates for each user and an effective means with which to deal with data that are generated. We plan to investigate several desktop systems, but our work to date has focused on a Cray CX1. Currently, we are investigating the potential capabilities of several non-traditional development environments. While most NASA and NOAA models are

  6. Ticks in the wrong boxes: assessing error in blanket-drag studies due to occasional sampling

    OpenAIRE

    Dobson, Andrew DM

    2013-01-01

    Background The risk posed by ticks as vectors of disease is typically assessed by blanket-drag sampling of host-seeking individuals. Comparisons of peak abundance between plots – either in order to establish their relative risk or to identify environmental correlates – are often carried out by sampling on one or two occasions during the period of assumed peak tick activity. Methods This paper simulates this practice by ‘re-sampling’ from model datasets derived from an empirical field study. R...

  7. A Black-box Modelling Engine for Discharge Produced Plasma Radiation Sources

    International Nuclear Information System (INIS)

    A Blackbox Modelling Engine (BME), is an instrument based on the adaptation of the RMHD code Z*, integrated into a specific computation environment to provide a turn key simulation instrument and to enable routine plasma modelling without specialist knowledge in numerical computation. Two different operating modes are provided: Detailed Physics mode and Fast Numerics mode. In the Detailed Physics mode, non-stationary, non-equilibrium radiation physics have been introduced to allow the modelling of transient plasmas in experimental geometry. In the Fast Numerics mode, the system architecture and the radiation transport is simplified to significantly accelerate the computation rate. The Fast Numerics mode allows the BME to be used realistically in parametric scanning to explore complex physical set up, before using the Detailed Physics mode. As an example of the results from the BME modelling, the EUV source plasma dynamics in the pulsed capillary discharge are presented

  8. Crash energy absorption of two-segment crash box with holes under frontal load

    Science.gov (United States)

    Choiron, Moch. Agus; Sudjito, Hidayati, Nafisah Arina

    2016-03-01

    Crash box is one of the passive safety components which designed as an impact energy absorber during collision. Crash box designs have been developed in order to obtain the optimum crashworthiness performance. Circular cross section was first investigated with one segment design, it rather influenced by its length which is being sensitive to the buckling occurrence. In this study, the two-segment crash box design with additional holes is investigated and deformation behavior and crash energy absorption are observed. The crash box modelling is performed by finite element analysis. The crash test components were impactor, crash box, and fixed rigid base. Impactor and the fixed base material are modelled as a rigid, and crash box material as bilinear isotropic hardening. Crash box length of 100 mm and frontal crash velocity of 16 km/jam are selected. Crash box material of Aluminum Alloy is used. Based on simulation results, it can be shown that holes configuration with 2 holes and ¾ length locations have the largest crash energy absorption. This condition associated with deformation pattern, this crash box model produces axisymmetric mode than other models.

  9. The MESSy aerosol submodel MADE3 (v2.0b): description and a box model test

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, J. C.; Hendricks, J.; Righi, M.; Riemer, Nicole; Zaveri, Rahul A.; Metzger, S.; Aquila, Valentino

    2014-06-17

    We introduce MADE3 (Modal Aerosol Dynamics for Europe, adapted for global applications, version 3), an aerosol dynamics submodel for application in a global chemistry general circulation model, that builds on the predecessor aerosol submodels MADE and MADE-in. The main new features of MADE3 are the explicit representation of coarse particle interactions with fine particles and gases, and the inclusion of the hydrochloric acid (HCl)/chloride (Cl) partitioning between the gas and condensed phases. The aerosol size distribution is represented in the new model as a superposition of nine lognormal modes: one for fully soluble particles, one for insoluble particles, and one for mixed particles in each of three size ranges (Aitken, accumulation, and coarse mode size ranges). In order to assess MADE3’s performance we compare it to its predecessor MADE and to the much more detailed particle-resolved aerosol model PartMC-MOSAIC in a box model application. MADE3 and MADE results are very similar, except when the aerosol is dominated by sea spray particles. In such cases, Cl concentrations are lower in MADE3 than in MADE due to the HCl/Cl partitioning. Additionally, the aerosol nitrate concentration is higher in MADE3 due to the uptake on coarse particles. MADE3 and PartMCMOSAIC show substantial differences in the fine particle size distributions (sizes . 2μm) that could be relevant when simulating climate effects on a global scale. Nevertheless, the agreement between MADE3 and PartMC-MOSAIC is very good when it comes to coarse particle size distribution, and also in terms of aerosol composition. Considering these results and the well-established ability of MADE in reproducing observed aerosol loadings and composition, MADE3 seems suitable for application within a global model.

  10. Efficient Parameterization for Grey-box Model Identification of Complex Physical Systems

    DEFF Research Database (Denmark)

    Blanke, Mogens; Knudsen, Morten

    2006-01-01

    better would be very useful. This paper shows how we can assess the parameter interdependence and model quality. Hessian matrix decomposition is employed to show linear dependencies between variables and to put a quality tag on different parameterizations. The method determines parameter relations that...

  11. Gray box modeling of MSW degradation: Revealing its dominant (bio)chemical mechanism

    NARCIS (Netherlands)

    Van Turnhout, A.G.; Heimovaara, T.J.; Kleerebezem, R.

    2013-01-01

    In this paper we present an approach to describe organic degradation within immobile water regions of Municipal Solid Waste (MSW) landfills which is best described by the term “gray box” model. We use a simplified set of dominant (bio)chemical and physical reactions and realistic environmental condi

  12. A case study of interior low-frequency noise from box-shaped bridge girders induced by running trains: Its mechanism, prediction and countermeasures

    Science.gov (United States)

    Zhang, Xun; Li, Xiaozhen; Hao, Hong; Wang, Dangxiong; Li, Yadong

    2016-04-01

    A side effect of high-speed railway and urban rail transit systems is the associated vibration and noise. Since the use of concrete viaducts is predominant in railway construction due to scarce land resources, low-frequency (20-200 Hz) structure-radiated noise from concrete bridges is a principal concern. Although it is the most commonly used bridge type, the mechanism of noise emission from box-shaped bridge girders when subjected to impact forces from moving trains, which sounds like beating a drum, has not been well studied. In this study, a field measurement was first made on a simply-supported box-shaped bridge to record the acceleration of the slabs and the associated sound pressures induced by running trains. These data indicated that a significant beat-wave noise occurred in the box-shaped cavity when the train speed was around 340 km/h, which arose from the interference between two sound waves of 75.0 Hz and 78.8 Hz. The noise leakage from the bridge expansion joint was serious and resulted in obvious noise pollution near the bridge once the beat-wave noise was generated in the cavity. The dominant frequency of the interior noise at 75.0 Hz was confirmed from the spectrum of the data and the modal analysis results, and originated from the peak vibration of the top slab due to resonance and the first-order vertical acoustic mode, which led to cavity resonance, amplifying the corresponding noise. The three-dimensional acoustic modes and local vibration modes of the slab were calculated by using the finite element method. A simplified vehicle-track-bridge coupling vibration model was then developed to calculate the wheel-rail interaction force in a frequency range of 20-200 Hz. Numerical simulations using the boundary element method confirmed the cavity resonance effect and the numerical results agreed well with the data. Based on the calibrated numerical model, three noise reduction measures, i.e., adding a horizontal baffle in the interior cavity, narrowing

  13. "White Box" Epidemiology and the Social Neuroscience of Health Behaviors: The Environmental Affordances Model.

    Science.gov (United States)

    Mezuk, Briana; Abdou, Cleopatra M; Hudson, Darrell; Kershaw, Kiarri N; Rafferty, Jane A; Lee, Hedwig; Jackson, James S

    2013-07-01

    Crucial advances have been made in our knowledge of the social determinants of health and health behaviors. Existing research on health disparities, however, generally fails to address a known paradox in the literature: While blacks have higher risk of medical morbidity relative to non-Hispanic whites, blacks have lower rates of common stress-related forms of psychopathology such as major depression and anxiety disorders. In this article we propose a new theoretical approach, the Environmental Affordances Model, as an integrative framework for the origins of both physical and mental health disparities. We highlight early empirical support and a growing body of experimental animal and human research on self-regulatory health behaviors and stress coping that is consistent with the proposed framework. We conclude that transdisciplinary approaches, such as the Environmental Affordances Model, are needed to understand the origins of group-based disparities to implement effective solutions to racial and ethnic group inequalities in physical and mental health. PMID:24224131

  14. Opening the Black Box: Using a Hydrological Model to Link Stakeholder Engagement with Groundwater Management

    OpenAIRE

    Susanna Eden; Sharon B. Megdal; Eylon Shamir; Karletta Chief; Kelly Mott Lacroix

    2016-01-01

    Stakeholder participation is a foundation of good water governance. Good groundwater governance typically involves the co-production of knowledge about the groundwater system. Models provide a vehicle for producing this knowledge, as well as a “boundary object” around which scientists and stakeholders can convene the co-production process. Through co-production, stakeholders and scientific experts can engage in exchanges that create system knowledge not otherwise achievable. The process invol...

  15. Tailored vs Black-Box Models for Forecasting Hourly Average Solar Irradiance

    Czech Academy of Sciences Publication Activity Database

    Brabec, Marek; Paulescu, M.; Badescu, V.

    2015-01-01

    Roč. 111, January (2015), s. 320-331. ISSN 0038-092X R&D Projects: GA MŠk LD12009 Grant ostatní: European Cooperation in Science and Technology(XE) COST ES1002 Institutional support: RVO:67985807 Keywords : solar irradiance * forecasting * tilored statistical models Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 3.469, year: 2014

  16. Gray box modeling of MSW degradation: Revealing its dominant (bio)chemical mechanism

    OpenAIRE

    Van Turnhout, A.G.; Heimovaara, T.J.; Kleerebezem, R.

    2013-01-01

    In this paper we present an approach to describe organic degradation within immobile water regions of Municipal Solid Waste (MSW) landfills which is best described by the term “gray box” model. We use a simplified set of dominant (bio)chemical and physical reactions and realistic environmental conditions. All equations, relationships and inhibitions are based on semi-empirical or fundamental relationships which have proven to be applicable in the peer reviewed literature. As much as possible ...

  17. High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study

    DEFF Research Database (Denmark)

    Gaïni, Shahin; Pedersen, Svend Stenvang; Koldkjaer, Ole Graesbøll;

    2008-01-01

    INTRODUCTION: Sepsis is a serious condition with a significant morbidity and mortality. New insight into the immunopathogenesis of sepsis could promote the development of new strategies for diagnosis and therapy. High mobility group box-1 protein (HMGB1) has been known for many years as a nuclear...... a department of internal medicine were included in the study in a prospective manner. Demographic data, comorbidity, routine biochemistry, microbiological data, infection focus, severity score, and mortality on day 28 were recorded. Plasma and serum were sampled at the time of admission. HMGB1...... non-infected patients and all infected patients, the area under the curve for HMGB1 was 0.59 (P < 0.0001). HMGB1 correlated only weakly to levels of white blood cell count, neutrophils, C-reactive protein, interleukin-6, procalcitonin, and lipopolysaccharide-binding protein (P < 0.001). HMGB1 did not...

  18. Beware the black box: investigating the sensitivity of FEA simulations to modelling factors in comparative biomechanics

    Directory of Open Access Journals (Sweden)

    Christopher W. Walmsley

    2013-11-01

    Full Text Available Finite element analysis (FEA is a computational technique of growing popularity in the field of comparative biomechanics, and is an easily accessible platform for form-function analyses of biological structures. However, its rapid evolution in recent years from a novel approach to common practice demands some scrutiny in regards to the validity of results and the appropriateness of assumptions inherent in setting up simulations. Both validation and sensitivity analyses remain unexplored in many comparative analyses, and assumptions considered to be ‘reasonable’ are often assumed to have little influence on the results and their interpretation. Here we report an extensive sensitivity analysis where high resolution finite element (FE models of mandibles from seven species of crocodile were analysed under loads typical for comparative analysis: biting, shaking, and twisting. Simulations explored the effect on both the absolute response and the interspecies pattern of results to variations in commonly used input parameters. Our sensitivity analysis focuses on assumptions relating to the selection of material properties (heterogeneous or homogeneous, scaling (standardising volume, surface area, or length, tooth position (front, mid, or back tooth engagement, and linear load case (type of loading for each feeding type. Our findings show that in a comparative context, FE models are far less sensitive to the selection of material property values and scaling to either volume or surface area than they are to those assumptions relating to the functional aspects of the simulation, such as tooth position and linear load case. Results show a complex interaction between simulation assumptions, depending on the combination of assumptions and the overall shape of each specimen. Keeping assumptions consistent between models in an analysis does not ensure that results can be generalised beyond the specific set of assumptions used. Logically, different

  19. Unconventional Bearing Capacity Analysis and Optimization of Multicell Box Girders

    Directory of Open Access Journals (Sweden)

    Jovan Tepic

    2014-01-01

    Full Text Available This study deals with unconventional bearing capacity analysis and the procedure of optimizing a two-cell box girder. The generalized model which enables the local stress-strain analysis of multicell girders was developed based on the principle of cross-sectional decomposition. The applied methodology is verified using the experimental data (Djelosevic et al., 2012 for traditionally formed box girders. The qualitative and quantitative evaluation of results obtained for the two-cell box girder is realized based on comparative analysis using the finite element method (FEM and the ANSYS v12 software. The deflection function obtained by analytical and numerical methods was found consistent provided that the maximum deviation does not exceed 4%. Multicell box girders are rationally designed support structures characterized by much lower susceptibility of their cross-sectional elements to buckling and higher specific capacity than traditionally formed box girders. The developed local stress model is applied for optimizing the cross section of a two-cell box carrier. The author points to the advantages of implementing the model of local stresses in the optimization process and concludes that the technological reserve of bearing capacity amounts to 20% at the same girder weight and constant load conditions.

  20. Partons of a spherical box

    International Nuclear Information System (INIS)

    Calculation of parton distributions in the 'cavity approximation' to the MIT bag model gives a divergent sum of positive terms. In this version of the model the flexible movable bag is replaced by an inflexible immovable box. This suggests that Bjorken scaling does not hold for the deep inelastic scattering in this version of the model. (K.A.)

  1. Previsão de demanda: uma aplicação dos modelos Box-Jenkins na área de assistência técnica de computadores pessoais Demand forecasting: an application of the Box-Jenkins models in the technical assistance of personal computer

    Directory of Open Access Journals (Sweden)

    Liane Werner

    2003-04-01

    Full Text Available A previsão de demanda é uma atividade importante para auxiliar na determinação dos recursos necessários para a empresa. Neste artigo, a metodologia de Box-Jenkins foi utilizada para analisar dados históricos de uma empresa de assistência técnica de computadores pessoais e obter previsões do número de atendimentos. A empresa estudada apresenta três tipos de clientes diferenciados: contratos, garantia e avulsos. Como cada segmento de clientes tem suas peculiaridades, a previsão de demanda foi direcionada a cada tipo, buscando representar o comportamento de tendência e a sazonalidade por meio dos modelos de Box-Jenkins. A obtenção dos modelos mais adequados foi baseada na análise de gráficos e em testes estatísticos próprios da metodologia, os quais subsidiaram a decisão de adotar o modelo AR(1 para prever o número de atendimentos dos clientes tipo contrato, o modelo ARIMA(2,1,0 para os clientes tipo garantia e um modelo sazonal SARIMA(0,1,0(0,1,112 para os clientes tipo avulsos.Demand forecasting is an important tool to aid on the determination of necessary resources of a given company. In this paper, the Box-Jenkins methodology was applied to analyze historical data of a personal computer repair company and provide a forecast for the number of service calls. The company studied presents three segments of clients: contracts, warranty, and on-call. As each client has it own characteristics, in order to better represent tendency and seasonality behavior through the Box-Jenkins models, a specific forecasting model was developed for each segment. The choice of the optimum models were based into graphic analysis and statistical tests, which lead to the decision of adopting the AR(1 model to foresee the number of contract clients, the ARIMA(2,1,0 model for warranty clients and the SARIMA(0,1,0(0,1,112 seasonal model for on-call clients.

  2. Geochemical monitoring of volcanic lakes. A generalized box model for active crater lakes

    OpenAIRE

    Rouwet, D.; Istituto Nazionale di Geofisica e Vulcanologia, Sezione Palermo, Palermo, Italia; Tassi, F.; Università degli Studi di Firenze, Dipartimento di Scienze della Terra, Firenze, Italy

    2011-01-01

    In the past, variations in the chemical contents (SO4 2−, Cl−, cations) of crater lake water have not systematically demonstrated any relationships with eruptive activity. Intensive parameters (i.e., concentrations, temperature, pH, salinity) should be converted into extensive parameters (i.e., fluxes, changes with time of mass and solutes), taking into account all the internal and external chemical–physical factors that affect the crater lake system. This study presents ...

  3. A Novel Intermediate Complexity box Model (ICBM) for Efficiently Simulating Marine C,N,P,O,S Biogeochemistry Over Geologic Time Scales: Applications for OAE Research

    Science.gov (United States)

    Romaniello, S. J.; Derry, L. A.

    2006-12-01

    Global marine redox conditions and marine nutrient status are tightly coupled on geologic timescales. Hypotheses that attempt to explain the occurrence of OAEs and/or the widespread deposition of organic-rich sediments must be dynamically plausible when viewed from the perspective of each of the major biological elements—C,N,P,O, and S. We present a new intermediate complexity box model (ICBM) capable of efficiently examining the coupled interactions of these cycles for a wide range of paleooceanographic hypotheses. Our ICBM fills a unique niche as a compromise between simple box models and more complicated EMICs and OGCMs. For computational speed, we employ a simple circulation model designed to avoid the pitfalls of early 2-3 box ocean models. In exchange, we represent the coupled major element cycles in considerable detail. This enables the biogeochemical submodel to simulate biological and chemical processes over a wide range of redox conditions, while providing efficient integration (1 My/hr). By prescribing simple representations of modern circulation and mixing, we are able to generate characteristic pelagic nutrient profiles and budgets for both the Global Ocean and the Black Sea, without changing the underlying biogeochemical model. We will present results from the simulation of several common explanations for OAEs, and discuss numerical estimates of the sensitivity and feedbacks in these hypothetical systems. Special emphasis will be placed on the interactions between global primary production, dissolved oxygen, nitrogen fixation, and anammox /denitrification.

  4. Submarine groundwater discharge to a small estuary estimated from radon and salinity measurements and a box model

    Science.gov (United States)

    Crusius, J.; Koopmans, D.; Bratton, J.F.; Charette, M.A.; Kroeger, K.D.; Henderson, P.; Ryckman, L.; Halloran, K.; Colman, J.A.

    2005-01-01

    Submarine groundwater discharge was quantified by a variety of methods in Salt Pond, adjacent to Nauset Marsh on Cape Cod, USA. Discharge estimates based on radon and salinity took advantage of the presence of the narrow channel connecting Salt Pond to Nauset Marsh, which allowed constructing whole-pond mass balances as water flowed in and out due to tidal fluctuations. A box model was used to estimate discharge separately to Salt Pond and to the channel by simulating the timing and magnitude of variations in the radon and salinity data in the channel. Discharge to the pond is estimated to be 2200??1100 m3 d-1, while discharge to the channel is estimated to be 300??150m3 d-1, for a total discharge of 2500??1250 m3 d-1 to the Salt Pond system. This translates to an average groundwater flow velocity of 3??1.5 cm d -1. Seepage meter flow estimates are broadly consistent with this figure, provided discharge is confined to shallow sediments (water depth estimated from the radon and salinity data is comparable to a value of 3200-4500 m3 d-1 predicted by a recent hydrologic model (Masterson, 2004; Colman and Masterson, 20041). Additional work is needed to determine if the measured rate of discharge is representative of the long-term average, and to determine the rate of groundwater discharge seaward of Salt Pond. Data also suggest a TDN flux from groundwater to Salt Pond of ???2.6 mmol m-2 d-1, a figure comparable to fluxes observed in other eutrophic settings.

  5. Changes of High Mobility Group box 1 in Serum of Pig Acute Hepatic Failure Model and Significance

    Institute of Scientific and Technical Information of China (English)

    Fan ZHANG; Yongwen HE; Zhongping DUAN

    2008-01-01

    The role of the high mobility group box 1 (HMGB-1) in acute hepatic failure and the ef- fect of artificial liver support system treatment on HMGB-1 level were investigated. Pig models of acute hepatic failure were induced by D-galactosamine and randomly divided into two groups with or without artificial liver support system treatment. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels were detected by the enzyme linked immunosorbent assay (ELISA), the expression of HMGB-1 by Western blot, and serum levels of HMGB-1, liver function and hepatic pathology were observed after artificial liver support system treatment. The levels of TNF-α and IL-1β were increased and reached the peak at 24th h in the acute hepatic failure group, then quickly decreased. The serum level of HMGB-1 was increased at 24th h in the acute hepatic failure group and reached the peak at 48th h, then kept a stable high level. Significant liver injury appeared at 24th h and was continuously getting worse in the pig models of acute hepatic failure. In contrast, the liver injury was significantly alleviated and serum level of HMGB-1 was significantly decreased in the group treated with artificial liver support system (P<0.05). It was suggested that HMGB-1 may participate in the inflammatory response and liver injury in the late stage of the acute liver failure. Artificial liver support system treatment can reduce serum HMGB-1 level and relieve liver pathological damage.

  6. Submarine groundwater discharge to a small estuary estimated from radon and salinity measurements and a box model

    Directory of Open Access Journals (Sweden)

    J. A. Colman

    2005-01-01

    Full Text Available Submarine groundwater discharge was quantified by a variety of methods in Salt Pond, adjacent to Nauset Marsh on Cape Cod, USA. Discharge estimates based on radon and salinity took advantage of the presence of the narrow channel connecting Salt Pond to Nauset Marsh, which allowed constructing whole-pond mass balances as water flowed in and out due to tidal fluctuations. A box model was used to estimate discharge separately to Salt Pond and to the channel by simulating the timing and magnitude of variations in the radon and salinity data in the channel. Discharge to the pond is estimated to be 2200±1100 m3d-1, while discharge to the channel is estimated to be 300±150 m3d-1, for a total discharge of 2500±1250 m3d-1 to the Salt Pond system. This translates to an average groundwater flow velocity of 3±1.5 cm d-1 Seepage meter flow estimates are broadly consistent with this figure, provided discharge is confined to shallow sediments (water depth 3d-1 predicted by a recent hydrologic model (Masterson, 2004; Colman and Masterson, 2004. Additional work is needed to determine if the measured rate of discharge is representative of the long-term average, and to determine the rate of groundwater discharge seaward of Salt Pond. Data also suggest a TDN flux from groundwater to Salt Pond of ~2.6 mmol m-2d-1, a figure comparable to fluxes observed in other eutrophic settings.

  7. Laryngeal (Voice Box) Cancer

    Science.gov (United States)

    ... Meeting Calendar Find an ENT Doctor Near You Voice Box (Laryngeal) Cancer Voice Box (Laryngeal) Cancer Patient Health Information News media ... laryngeal cancer can be severe with respect to voice, breathing, or swallowing. It is fundamentally a preventable ...

  8. Understanding Recommender Dynamics driving Box Office Revenues

    CERN Document Server

    Yeung, C H; Jin, C -H

    2010-01-01

    We introduce a simple model to investigate the underlying dynamics driving movie box office. Without an explicit reliance on time, the box office of movies evolves naturally by movie-movie competition through reviews listed on a centralized recommender system. A simple mean-field approximation is employed which assumes an average interaction between the competing movies, and describes the interesting box office dynamics. Box office hits are found for movies with quality beyond a critical value, leading to booms in gross box office. Such critical value is dependent on the reviewing behaviors, intention of movie goers for new movies, and the quality of the peer competing movies. Finally we compare our analytical results with simulations and real system and obtain qualitative agreements, suggesting the present model in describing the fundamental dynamics of box office.

  9. The MESSy aerosol submodel MADE3 (v2.0b: description and a box model test

    Directory of Open Access Journals (Sweden)

    J. C. Kaiser

    2014-06-01

    Full Text Available We introduce MADE3 (Modal Aerosol Dynamics model for Europe, adapted for global applications, 3rd generation; version: MADE3v2.0b, an aerosol dynamics submodel for application within the MESSy framework (Modular Earth Submodel System. MADE3 builds on the predecessor aerosol submodels MADE and MADE-in. Its main new features are the explicit representation of coarse mode particle interactions both with other particles and with condensable gases, and the inclusion of hydrochloric acid (HCl / chloride (Cl partitioning between the gas and condensed phases. The aerosol size distribution is represented in the new submodel as a superposition of nine lognormal modes: one for fully soluble particles, one for insoluble particles, and one for mixed particles in each of three size ranges (Aitken, accumulation, and coarse mode size ranges. In order to assess the performance of MADE3 we compare it to its predecessor MADE and to the much more detailed particle-resolved aerosol model PartMC-MOSAIC in a box model simulation of an idealised marine boundary layer test case. MADE3 and MADE results are very similar, except in the coarse mode, where the aerosol is dominated by sea spray particles. Cl is reduced in MADE3 with respect to MADE due to the HCl / Cl partitioning that leads to Cl removal from the sea spray aerosol in our test case. Additionally, the aerosol nitrate concentration is higher in MADE3 due to the condensation of nitric acid on coarse mode particles. MADE3 and PartMC-MOSAIC show substantial differences in the fine particle size distributions (sizes ≲ 2 μm that could be relevant when simulating climate effects on a global scale. Nevertheless, the agreement between MADE3 and PartMC-MOSAIC is very good when it comes to coarse particle size distributions (sizes ≳ 2 μm, and also in terms of aerosol composition. Considering these results and the well-established ability of MADE in reproducing observed aerosol loadings and composition

  10. The MESSy aerosol submodel MADE3 (v2.0b: description and a box model test

    Directory of Open Access Journals (Sweden)

    J. C. Kaiser

    2014-01-01

    Full Text Available We introduce MADE3 (Modal Aerosol Dynamics model for Europe, adapted for global applications, 3rd generation, an aerosol dynamics submodel for application within the MESSy framework (Modular Earth Submodel System. MADE3 builds on the predecessor aerosol submodels MADE and MADE-in. Its main new features are the explicit representation of coarse particle interactions both with other particles and with condensable gases, and the inclusion of hydrochloric acid (HCl/chloride (Cl partitioning between the gas and condensed phases. The aerosol size distribution is represented in the new submodel as a superposition of nine lognormal modes: one for fully soluble particles, one for insoluble particles, and one for mixed particles in each of three size ranges (Aitken, accumulation, and coarse mode size ranges. In order to assess the performance of MADE3 we compare it to its predecessor MADE and to the much more detailed particle-resolved aerosol model PartMC-MOSAIC in a box model simulation of an idealised marine boundary layer test case. MADE3 and MADE results are very similar, except in the coarse mode, where the aerosol is dominated by sea spray particles. Cl is reduced in MADE3 with respect to MADE due to the HCl/Cl partitioning that leads to Cl removal from the sea spray aerosol in our test case. Additionally, aerosol nitrate concentration is higher in MADE3 due to the condensation of nitric acid on coarse particles. MADE3 and PartMC-MOSAIC show substantial differences in the fine particle size distributions (sizes ≲ 2 μm that could be relevant when simulating climate effects on a global scale. Nevertheless, the agreement between MADE3 and PartMC-MOSAIC is very good when it comes to coarse particle size distribution, and also in terms of aerosol composition. Considering these results and the well-established ability of MADE in reproducing observed aerosol loadings and composition, MADE3 seems suitable for application within a global model.

  11. Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease : lessons from animal models

    NARCIS (Netherlands)

    Schaper, Fleur; Heeringa, Peter; Bijl, Marc; Westra, Johanna

    2013-01-01

    Purpose of review High-mobility group box 1 (HMGB1) is a molecule that has gained much attention in the last couple of years as an important player in innate immune responses and modulating factor in several (auto) immune diseases. Furthermore, advancements have been made in identifying the diverse

  12. Using dynamic N-mixture models to test cavity limitation on northern flying squirrel demographic parameters using experimental nest box supplementation.

    Science.gov (United States)

    Priol, Pauline; Mazerolle, Marc J; Imbeau, Louis; Drapeau, Pierre; Trudeau, Caroline; Ramière, Jessica

    2014-06-01

    Dynamic N-mixture models have been recently developed to estimate demographic parameters of unmarked individuals while accounting for imperfect detection. We propose an application of the Dail and Madsen (2011: Biometrics, 67, 577-587) dynamic N-mixture model in a manipulative experiment using a before-after control-impact design (BACI). Specifically, we tested the hypothesis of cavity limitation of a cavity specialist species, the northern flying squirrel, using nest box supplementation on half of 56 trapping sites. Our main purpose was to evaluate the impact of an increase in cavity availability on flying squirrel population dynamics in deciduous stands in northwestern Québec with the dynamic N-mixture model. We compared abundance estimates from this recent approach with those from classic capture-mark-recapture models and generalized linear models. We compared apparent survival estimates with those from Cormack-Jolly-Seber (CJS) models. Average recruitment rate was 6 individuals per site after 4 years. Nevertheless, we found no effect of cavity supplementation on apparent survival and recruitment rates of flying squirrels. Contrary to our expectations, initial abundance was not affected by conifer basal area (food availability) and was negatively affected by snag basal area (cavity availability). Northern flying squirrel population dynamics are not influenced by cavity availability at our deciduous sites. Consequently, we suggest that this species should not be considered an indicator of old forest attributes in our study area, especially in view of apparent wide population fluctuations across years. Abundance estimates from N-mixture models were similar to those from capture-mark-recapture models, although the latter had greater precision. Generalized linear mixed models produced lower abundance estimates, but revealed the same relationship between abundance and snag basal area. Apparent survival estimates from N-mixture models were higher and less precise

  13. Brazilian Cinema: A Comparative Study between Fundraising Through Mechanisms of Public Incentive versus the Selling Revenue on the Brazilian Box Offices

    Directory of Open Access Journals (Sweden)

    Inácio Alaiola Nogueira Dos Santos Júnior

    2014-12-01

    Full Text Available Responsible for maintaining active the actual cinematographic production, the politics of incentive to cinema do not guarantee an equal state of recourse capture for all the movies produced in the country as well as provoke discussion which relate production quality to volume capture, in which has taken to the creation of the common sense that says that movies which present elevated recourse fund must present best-selling results. Therefore, this study has the objective of analyzing the relation between the recourse volume captured from the mechanisms of public incentive and the selling volume on the Brazilian box offices. Due to that, descriptive research was made, with documentary character and quantitative approach. The data used in this study is related to information towards fundraising and income about the box office of 666 brazilian movies released between 1995 and 2012, while the statistical analysis used was the 'Spearman correlation' coefficient. The results showed that there is a strong positive correlation between the two variablesanalyzed, revealing a trend of movies with high fundraising are the ones that register the highest grossing box office. Data analysis also revealed that there is a concentration of both incentive funds (61% as income at the box office (75% in films with volume greater uptake of R $ 3 million.

  14. Reliability Based Optimum Design of a Gear Box

    Directory of Open Access Journals (Sweden)

    D.Madhusekhar

    2014-10-01

    Full Text Available The gear box represents an important mechanical sub system. In machine tools, the propose of a gear box is to provide a series of useful output speeds so that the machining operation can be carried out at its most optimum operating conditions high spindle speeds with low feed rate for roughing operations. An important aspect in the design of machine tool transmission is to keep the cost and volume of the gear box to a minimum. The probabilistic approach to design has been considered to be more rational compared to the conventional design approach based on the factor of safety. The existence of uncertainties in either engineering simulations or manufacturing processes calls for a reliability-based design optimization (RBDO model for robust and cost-effective designs. In the present work a three shaft four speed gear box is designed using reliability principles. For the specified reliability of the system (Gear box, component reliability (Gear pair is calculated by considering the system as a series system. Design is considered to be safe and adequate if the probability of failure of gear box is less than or equal to a specified quantity in each of the two failure modes. A FORTRAN program has been developed to calculate the mean values of face widths of gears for the minimum mass of gear box. By changing the probability of failure of system variations in the face widths are studied. The reliability based optimum design results are compared with those obtained by deterministic optimum design. The minimum mass of the gear box is increase as the specified values of the reliability is increased.

  15. Exploring the Black Box in Brazilian Work Groups: a Study of Diversity, Conflict and Performance

    OpenAIRE

    Filipe Sobral; Daan Bisseling

    2012-01-01

    Over the last few decades, several studies have been conducted to examine the complex relationships betweenteam diversity and individual and organizational outcomes. Although, in theory, team diversity can fosterpositive organizational synergies by increasing the variance of perspectives and approaches to work differentmembers can bring, the same idiosyncratic characteristics can also engender significant difficulties resultingfrom problems in coordination, communication and conflict. This st...

  16. Study for the Revision of the plaice box - Draft Final Report

    NARCIS (Netherlands)

    Beare, D.J.; Rijnsdorp, A.D.; Kooten, van T.; Fock, H.; Witbaard, R.; Meesters, H.W.G.; Quirijns, F.J.

    2010-01-01

    This project has attempted to evaluate the effectiveness of the fisheries management measure known as the “Plaice Box” (PB) for the conservation of plaice and other species of marine organisms in the south-eastern North Sea. The study provides an inventory of existing information and collects new ma

  17. Effect of an odor eliminator on feline litter box behavior.

    Science.gov (United States)

    Cottam, Nicole; Dodman, Nicholas H

    2007-02-01

    Decreasing litter box odor may be an important treatment component in addressing feline inappropriate elimination. A three-phase study was conducted to determine if the use of Zero Odor litter box spray increases the preference of litter boxes to cats, presumably by its odor-eliminating quality. In the first phase, cats were given a litter box preference test between a litter box sprayed with Zero Odor and one without. In the second phase, the number of occurrences of behaviors indicative of a cat's dissatisfaction with the litter box (scratching at the sides of the box, floor or wall, hesitating when entering the litter box, balancing on the side of the box and eliminating outside of the litter box) was compared before and after the use of Zero Odor. Last, the frequency of eliminations that occurred outside the litter box was measured during a baseline phase and a test phase, in which Zero Odor was sprayed into all litter boxes in the home. Significantly fewer behaviors associated with feline litter box dissatisfaction and fewer undesirable eliminations were observed in phases 2 and 3, respectively. These findings suggest that use of Zero Odor litter box spray appears to decrease litter box odor and increases the attractiveness of litter box to cats. PMID:17049291

  18. Study for the Revision of the plaice box - Draft Final Report

    OpenAIRE

    Beare, D.J.; Rijnsdorp, A.D.; Kooten, van, J.; Fock, H. (Heino); Witbaard, R.; Meesters, H.W.G.; Quirijns, F.J.

    2010-01-01

    This project has attempted to evaluate the effectiveness of the fisheries management measure known as the “Plaice Box” (PB) for the conservation of plaice and other species of marine organisms in the south-eastern North Sea. The study provides an inventory of existing information and collects new material on the effects of the PB on the conservation of plaice and the impact of the PB on various components of the commercial fishing fleets. Based on an analysis of key processes that affect the ...

  19. Exploring the Black Box in Brazilian Work Groups: a Study of Diversity, Conflict and Performance

    Directory of Open Access Journals (Sweden)

    Filipe Sobral

    2012-04-01

    Full Text Available Over the last few decades, several studies have been conducted to examine the complex relationships betweenteam diversity and individual and organizational outcomes. Although, in theory, team diversity can fosterpositive organizational synergies by increasing the variance of perspectives and approaches to work differentmembers can bring, the same idiosyncratic characteristics can also engender significant difficulties resultingfrom problems in coordination, communication and conflict. This study used a sample of 44 work groups toexamine the influence of five types of diversity on team outcomes and the mediating role of task and relationalconflict on this relationship. A survey of 279 team members and interviews with the 44 team managers wereused to examine these relationships. Findings suggest that different forms of diversity impact task conflict indifferent ways, which in turn is negatively associated with job satisfaction and team performance. Results furthershow that diversity is unrelated to relational conflict; however, this type of conflict seems to hinder both jobsatisfaction and team performance. Overall, these patterns suggest a complex link between team diversity andhow work groups function.

  20. An experimental study on two-story reinforced concrete box-shaped and truncated cone-shaped shear walls

    International Nuclear Information System (INIS)

    An experimental investigation has been performed upon shear wall specimens representing the inner and shield walls in a boiling water reactor (BWR) type reactor building. A set of three two-storey specimens were prepared. One is a sophisticated shear wall component composed of box-shaped and truncated cone-shaped walls interacting with each other. The other two are, respectively, box-shaped and truncated cone-shaped shear walls. A cyclic lateral loading program has been established from an analysis subjected to seismic excitation. The load-deflection characteristics, the deformation of the components, and the strain of concrete and reinforcing bars were examined. The results obtained from the sophisticated wall are compared with those obtained individually from the box-shaped and cone-shaped walls. Discussion on the observed characteristics leads to the evidence that the behaviors of the sophisticated wall can be successfully estimated from those of its corresponding individual wall components. (author)

  1. Black-Box Search by Unbiased Variation

    DEFF Research Database (Denmark)

    Lehre, Per Kristian; Witt, Carsten

    2012-01-01

    The complexity theory for black-box algorithms, introduced by Droste, Jansen, and Wegener (Theory Comput. Syst. 39:525–544, 2006), describes common limits on the efficiency of a broad class of randomised search heuristics. There is an obvious trade-off between the generality of the black-box model...

  2. Identifying competencies of boxing coaches

    Directory of Open Access Journals (Sweden)

    Ioannis Tasiopoulos

    2014-10-01

    Full Text Available The purpose of this study was to find out the management skills required by boxing coaches to administrate their clubs. For the purposes of this study a scale was constructed which was answered by 98 boxing coaches. Explanatory factor analysis revealed seven factors: Communication-public relations (5 items, event management (4 items, management techniques (4 items, new technologies (4 items, prevention-safety (2 items, sport (5 items and sports facilities (2 items. The Cronbach of the scale was 0.85. The five competencies that rated by the coaches were: Supervisors of the area of training, maintaining excellent communication with athletes, using new technologies (e-mail, internet, handling disciplinary matters, accidents, complaints and reports on some sporting games and promoted harmony among athletes. We concluded that boxing coaches understand that the competencies required for meeting their obligations, were related to sports, prevention, safety and communications-public relations.

  3. Modelling of biospheric CO2 gross fluxes via oxygen isotopes in a spruce forest canopy: a 222Rn calibrated box model approach

    International Nuclear Information System (INIS)

    One-dimensional box model estimates of biospheric CO2 gross fluxes are presented. The simulations are based on a set of measurements performed during the EUROSIBERIAN CARBONFLUX intensive campaign between 27 July and 1 August 1999 in a natural Picea abies forest in Russia. CO2 mixing ratios and stable isotope ratios of CO2 were measured on flask samples taken in two heights within the canopy. Simultaneously, soil and leaf samples were collected and analysed to derive the 18O/16O ratio of the respective water reservoirs and the 13C/12C ratio of the leaf tissue. The main objective of this project was to investigate biospheric gas exchange with soil and vegetation, and thereby take advantage of the potential of the 18O/16O ratio in atmospheric CO2. Via exchange of oxygen isotopes with associated liquid water reservoirs, leaf CO2 assimilation fluxes generally enrich while soil CO2 respiration fluxes generally deplete the18O/16O ratio of atmospheric CO. In the model, we parameterised intra-canopy transport by exploiting soil-borne Rn as a tracer for turbulent transport. Our model approach showed that, using oxygen isotopes, the net ecosystem CO2 flux can be separated into assimilation and respiration yielding fluxes comparable with those derived by other methods. However, partitioning is highly sensitive to the respective discrimination factors, and therefore also on the parameterisation of internal leaf CO2 concentrations and gradients

  4. Asymptotic Symmetries from finite boxes

    CERN Document Server

    Andrade, Tomas

    2015-01-01

    It is natural to regulate an infinite-sized system by imposing a boundary condition at finite distance, placing the system in a "box." This breaks symmetries, though the breaking is small when the box is large. One should thus be able to obtain the asymptotic symmetries of the infinite system by studying regulated systems. We provide concrete examples in the context of Einstein-Hilbert gravity (with negative or zero cosmological constant) by showing in 4 or more dimensions how the Anti-de Sitter and Poincar\\'e asymptotic symmetries can be extracted from gravity in a spherical box with Dirichlet boundary conditions. In 2+1 dimensions we obtain the full double-Virasoro algebra of asymptotic symmetries for AdS$_3$ and, correspondingly, the full Bondi-Metzner-Sachs (BMS) algebra for asymptotically flat space. In higher dimensions, a related approach may continue to be useful for constructing a good asymptotically flat phase space with BMS asymptotic symmetries.

  5. Asymptotic symmetries from finite boxes

    Science.gov (United States)

    Andrade, Tomás; Marolf, Donald

    2016-01-01

    It is natural to regulate an infinite-sized system by imposing a boundary condition at finite distance, placing the system in a 'box.' This breaks symmetries, though the breaking is small when the box is large. One should thus be able to obtain the asymptotic symmetries of the infinite system by studying regulated systems. We provide concrete examples in the context of Einstein-Hilbert gravity (with negative or zero cosmological constant) by showing in 4 or more dimensions how the anti-de Sitter and Poincaré asymptotic symmetries can be extracted from gravity in a spherical box with Dirichlet boundary conditions. In 2 + 1 dimensions we obtain the full double-Virasoro algebra of asymptotic symmetries for AdS3 and, correspondingly, the full Bondi-Metzner-Sachs (BMS) algebra for asymptotically flat space. In higher dimensions, a related approach may continue to be useful for constructing a good asymptotically flat phase space with BMS asymptotic symmetries.

  6. ELM resolved energy distribution studies in the JET MKII Gas-Box divertor using infra-red thermography

    International Nuclear Information System (INIS)

    Using infra-red (IR) thermography, power loads onto the MKII Gas-Box divertor targets have been investigated in Type-I ELMy H-Mode plasmas at JET in medium current discharges (Ip = 2.6 MA and BT = 2.7 T). Heat fluxes are calculated from the measured divertor target tile surface temperatures taking into account the influence of co-deposited surface layers on tile surfaces. This is particularly important when estimating the energy deposition during transient events such as ELMs. Detailed energy balance analysis is used, both from IR and tile embedded thermocouples, to demonstrate an approximately constant ELM-averaged in/out divertor target asymmetry of ∼0.55 and to show that the ELM in/out energy deposition ratio ranges from 1 : 1 to 2 : 1. The inter-ELM in/out ratio is close to the ELM-averaged value at low pedestal collisionalities and decreases down to values close to zero when the inner target plasma detaches at the highest pedestal collisionalities. The fraction of ELM transported energy is observed to behave differently for the inner and the outer divertor. At higher pedestal collisionalities nearly the full inner target load is due to the ELMs whereas for the outer target the ELM transported energy never exceeds values of ∼ 0.3 of the total energy deposited there. The fraction of ELM energy arriving at the divertor compared with the pedestal loss energy in JET is found to be in the range of 0.75 for small ELMs down to 0.4 for large ELMs systematically decreasing with normalized ELM size. Since ITER is bound to use small ELMs the corresponding ELM wall load is expected to be small. The latter experimental result is in fair agreement with the observation that larger ELMs tend to travel faster across the SOL than smaller ELMs. However, a comparison of the presented data with models of ELM perpendicular transport is not conclusive due to the large experimental errorbars and uncertainties in the model assumptions

  7. Optimization of parameters for cerium(III) biosorption onto biowaste materials of animal and plant origin using 5-level Box-Behnken design:Equilibrium, kinetic, thermodynamic and regeneration studies

    Institute of Scientific and Technical Information of China (English)

    Jaya Sre Varsihini C; Devlina Das; Nilanjana Das

    2014-01-01

    Response surface methodology (RSM) employing 5-level Box-Behnken design was used to optimize the biosorption of ce-rium(III) onto biowaste materials of animal and plant origin viz. prawn carapace (PC) and corn style (CS). Various process parame-ters viz. pH (A:3.0-9.0), biomass dosage (B:0.05-0.35 g/L), initial metal concentration (C:50-350 mg/L), contact time (D:2-6 h) and temperature (E:20-60 °C) were chosen for optimization. A log transformation was suggested by the Box-Cox plot in the present case. A low p-value of<0.0001 validated the significance of the model. Maximum Ce(III) uptake of 218.3 mg/g for PC and 180.2 mg/g for CS was noted under optimum conditions. Among the equilibrium isotherms, Freundlich model was found to be the best fit-ted one suggesting a heterogeneous mode of biosorption on PC whereas Langmuir model showed the best fit suggesting homogene-ous mode of cerium biosorption on CS. This was further confirmed by scanning electron microscopy (SEM). Kinetic studies showed better applicability of pseudo-first order model suggesting physisorption as phenomena underlying the process. Film-diffusion was suggested by the non-linearity of the Boyd plot. Thermodynamic studies showed that the process was endothermic and spontaneous. FTIR analysis confirmed a major involvement of the participation of amide, amines, ketones and primary alcohol groups during Ce(III) biosorption. EDAX analysis confirmed the major participation of carbon group during Ce(III) biosorption. This was the first report on parameter optimization of Ce(III) biosorption onto biowaste materials using 5-level Box-Behnken experimental design which might be helpful for the recovery of Ce(III) from aqueous environment.

  8. Do Mirror Glasses Have the Same Effect on Brain Activity as a Mirror Box? Evidence from a Functional Magnetic Resonance Imaging Study with Healthy Subjects

    OpenAIRE

    Milde, Christopher; Rance, Mariela; Kirsch, Pinar; Trojan, Jörg; Fuchs, Xaver; Foell, Jens; Bekrater-Bodmann, Robin; Flor, Herta; Diers, Martin

    2015-01-01

    Since its original proposal, mirror therapy has been established as a successful neurorehabilitative intervention in several neurological disorders to recover motor function or to relieve pain. Mirror therapy seems to operate by reactivating the contralesional representation of the non-mirrored limb in primary motor- and somatosensory cortex. However, mirror boxes have some limitations which prompted the use of additional mirror visual feedback devices. The present study evaluated the utility...

  9. The feasibility and effectiveness of high-intensity boxing training versus moderate-intensity brisk walking in adults with abdominal obesity: a pilot study

    OpenAIRE

    Birinder S. Cheema; Davies, Timothy B; Stewart, Matthew; Papalia, Shona; Atlantis, Evan

    2015-01-01

    Background High-intensity interval training (HIIT) performed on exercise cycle or treadmill is considered safe and often more beneficial for fat loss and cardiometabolic health than moderate-intensity continuous training (MICT). The aim of this pilot study was to assess the feasibility and effectiveness of a 12-week boxing training (HIIT) intervention compared with an equivalent dose of brisk walking (MICT) in obese adults. Methods Men and women with abdominal obesity and body mass index >25 ...

  10. Shaping 3-D boxes

    DEFF Research Database (Denmark)

    Stenholt, Rasmus; Madsen, Claus B.

    2011-01-01

    Enabling users to shape 3-D boxes in immersive virtual environments is a non-trivial problem. In this paper, a new family of techniques for creating rectangular boxes of arbitrary position, orientation, and size is presented and evaluated. These new techniques are based solely on position data...

  11. Study of alternatives for obtaining statistical correlation models for modelling the rough honing process

    OpenAIRE

    Buj Corral, Irene; Vivancos Calvet, Joan; Soler Sala, Bernat

    2014-01-01

    In the present paper, in order to model rough honing operations, statistical regression correlation models are presented for surface roughness and material removal rate as a function of process variables. Several different models were studied: linear, quadratic, exponential, etc. In addition, Box-Cox transformations were performed to the models so as to improve their fit. Models were compared taking into account two different criteria: R2(Adjusted) coefficient and R2(Predicted) coefficient. R...

  12. Quantifying and Reducing Model-Form Uncertainties in Reynolds-Averaged Navier-Stokes Equations: An Open-Box, Physics-Based, Bayesian Approach

    CERN Document Server

    Xiao, H; Wang, J -X; Sun, R; Roy, C J

    2015-01-01

    Despite their well-known limitations, Reynolds-Averaged Navier-Stokes (RANS) models are still the workhorse tools for turbulent flow simulations in today's engineering applications. For many practical flows, the turbulence models are by far the most important source of uncertainty. In this work we develop an open-box, physics-informed Bayesian framework for quantifying model-form uncertainties in RANS simulations. Uncertainties are introduced directly to the Reynolds stresses and are represented with compact parameterization accounting for empirical prior knowledge and physical constraints (e.g., realizability, smoothness, and symmetry). An iterative ensemble Kalman method is used to assimilate the prior knowledge and observation data in a Bayesian framework, and to propagate them to posterior distributions of velocities and other Quantities of Interest (QoIs). We use two representative cases, the flow over periodic hills and the flow in a square duct, to evaluate the performance of the proposed framework. Si...

  13. Broken links and black boxes

    DEFF Research Database (Denmark)

    Sindbæk, Søren Michael

    2013-01-01

    Long-distance communication has emerged as a particular focus for archaeological exploration using network theory, analysis, and modelling. Initial attempts to adapt methods from social network analysis to archaeological data have, however, struggled to produce decisive results. This paper argues...... ruined network from observable distributions and patterns of association in the archaeological record. In formal terms this is not a problem of network analysis, but network synthesis: the classic problem of cracking codes or reconstructing black-box circuits....

  14. The Maine Music Box

    OpenAIRE

    Lutz, Marilyn; Gallucci, Laura

    2005-01-01

    The paper describes the Maine Music Box and examines its potential as a tool for teaching and learning music. Pedagogical concepts are demonstrated using MIDI, Scorch, image and streaming video files.

  15. Voice box (image)

    Science.gov (United States)

    The larynx, or voice box, is located in the neck and performs several important functions in the body. The larynx is involved in swallowing, breathing, and voice production. Sound is produced when the air which ...

  16. Box Model of a Series of Salt Ponds, as Applied to the Alviso Salt Pond Complex, South San Francisco Bay, California

    Science.gov (United States)

    Lionberger, Megan A.; Schoellhamer, David H.; Shellenbarger, Gregory; Orlando, James L.; Ganju, Neil K.

    2007-01-01

    This report documents the development and application of a box model to simulate water level, salinity, and temperature of the Alviso Salt Pond Complex in South San Francisco Bay. These ponds were purchased for restoration in 2003 and currently are managed by the U.S. Fish and Wildlife Service to maintain existing wildlife habitat and prevent a build up of salt during the development of a long-term restoration plan. The model was developed for the purpose of aiding pond managers during the current interim management period to achieve these goals. A previously developed box model of a salt pond, SPOOM, which calculates daily pond volume and salinity, was reconfigured to simulate multiple connected ponds and a temperature subroutine was added. The updated model simulates rainfall, evaporation, water flowing between the ponds and the adjacent tidal slough network, and water flowing from one pond to the next by gravity and pumps. Theoretical and measured relations between discharge and corresponding differences in water level are used to simulate most flows between ponds and between ponds and sloughs. The principle of conservation of mass is used to calculate daily pond volume and salinity. The model configuration includes management actions specified in the Interim Stewardship Plan for the ponds. The temperature subroutine calculates hourly net heat transfer to or from a pond resulting in a rise or drop in pond temperature and daily average, minimum, and maximum pond temperatures are recorded. Simulated temperature was compared with hourly measured data from pond 3 of the Napa?Sonoma Salt Pond Complex and monthly measured data from pond A14 of the Alviso Salt-Pond Complex. Comparison showed good agreement of measured and simulated pond temperature on the daily and monthly time scales.

  17. Sequential Convex Programming for Power Set-point Optimization in a Wind Farm using Black-box Models, Simple Turbine Interactions, and Integer Variables

    DEFF Research Database (Denmark)

    Hovgaard, Tobias Gybel; Larsen, Lars F. S.; Jørgensen, John Bagterp;

    2012-01-01

    We consider the optimization of power set-points to a large number of wind turbines arranged within close vicinity of each other in a wind farm. The goal is to maximize the total electric power extracted from the wind, taking the wake effects that couple the individual turbines in the farm into...... account. For any mean wind speed, turbulence intensity, and direction we find the optimal static operating points for the wind farm. We propose an iterative optimization scheme to achieve this goal. When the complicated, nonlinear, dynamics of the aerodynamics in the turbines and of the fluid dynamics...... describing the turbulent wind fields’ propagation through the farm are included in a highly detailed black-box model, numerical results for any given values of the parameter sets can easily be evaluated. However, analytic expressions for model representation in the optimization algorithms might be hard to...

  18. Developing the intervention material to increase physical activity levels of European preschool children: the ToyBox-study.

    Science.gov (United States)

    Duvinage, K; Ibrügger, S; Kreichauf, S; Wildgruber, A; De Craemer, M; De Decker, E; Androutsos, O; Lateva, M; Iotova, V; Socha, P; Zych, K; Mouratidou, T; Mesana Graffe, M I; Manios, Y; Koletzko, B

    2014-08-01

    Early childhood is an important period for adopting positive health-related behaviours. More than 95% of European preschool children attend kindergartens, making these settings ideal for the implementation of health promotion interventions. The ToyBox-intervention addressed preschool children, their parents/caregivers and teachers. The aim of the intervention was to improve four energy balance-related behaviours (i.e. healthy snacking, water consumption, physical activity and sedentary behaviour) by implementing a kindergarten-based, family-involved intervention in six European countries (Belgium, Bulgaria, Germany, Greece, Poland and Spain). The intervention material was developed following the intervention mapping protocol, taking into account local and cultural differences among the intervention countries. The present paper focuses on the development of the physical activity component of the intervention. Parental involvement was addressed by providing parents/caregivers with two newsletters, two tip cards and a poster. Teachers received a handbook with guidance on environmental changes in the classroom, 26 physical education sessions and suggestions for fun, interactive classroom activities aiming at total class participation to increase preschoolers' physical activity levels. The ToyBox-intervention material was distributed according to a standard time frame. Teachers received their material prior to the start of the intervention and parents/caregivers received their material during the intervention when each energy balance-related behaviour was implemented. PMID:25047376

  19. SET Backaction on the Single Electron Box

    OpenAIRE

    Turek, B. A.; Lehnert, K. W.; Clerk, A.; Gunnarsson, D.; Bladh, K.; Delsing, P.; Schoelkopf, R. J.

    2005-01-01

    We report an experimental observation of the backaction of a Single Electron Transistor (SET) measuring the Coulomb staircase of a single electron box. As current flows through the SET, the charge state of the SET island fluctuates. These fluctuations capacitively couple to the box and cause changes in the position, width, and asymmetry of the Coulomb staircase. A sequential tunnelling model accurately recreates these effects, confirming this mechanism of the backaction of an SET. This is a f...

  20. Business plan PME.Box: internationalization to Spain

    OpenAIRE

    Pinto, Diogo José Gomes Ferreira

    2011-01-01

    The document herein described, provides detailed information of the development of PME.BOX Business Plan regarding the expansion to a detailed overview of the business model and strategies that PME.BOX looks to implement in order to maximize its business reach and in turn generate revenue. PME.BOX (firm) is an IT start up firm based in Madan Par the commercial rights of pme.box (software). Pme.box is a touch management solution intended to help small and medium enterprises (SMEs) in ...

  1. Utilizing the Iterative Closest Point (ICP) algorithm for enhanced registration of high resolution surface models - more than a simple black-box application

    Science.gov (United States)

    Stöcker, Claudia; Eltner, Anette

    2016-04-01

    Advances in computer vision and digital photogrammetry (i.e. structure from motion) allow for fast and flexible high resolution data supply. Within geoscience applications and especially in the field of small surface topography, high resolution digital terrain models and dense 3D point clouds are valuable data sources to capture actual states as well as for multi-temporal studies. However, there are still some limitations regarding robust registration and accuracy demands (e.g. systematic positional errors) which impede the comparison and/or combination of multi-sensor data products. Therefore, post-processing of 3D point clouds can heavily enhance data quality. In this matter the Iterative Closest Point (ICP) algorithm represents an alignment tool which iteratively minimizes distances of corresponding points within two datasets. Even though tool is widely used; it is often applied as a black-box application within 3D data post-processing for surface reconstruction. Aiming for precise and accurate combination of multi-sensor data sets, this study looks closely at different variants of the ICP algorithm including sub-steps of point selection, point matching, weighting, rejection, error metric and minimization. Therefore, an agricultural utilized field was investigated simultaneously by terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) sensors two times (once covered with sparse vegetation and once bare soil). Due to different perspectives both data sets show diverse consistency in terms of shadowed areas and thus gaps so that data merging would provide consistent surface reconstruction. Although photogrammetric processing already included sub-cm accurate ground control surveys, UAV point cloud exhibits an offset towards TLS point cloud. In order to achieve the transformation matrix for fine registration of UAV point clouds, different ICP variants were tested. Statistical analyses of the results show that final success of registration and therefore

  2. Effect and Process Evaluation of a Cluster Randomized Control Trial on Water Intake and Beverage Consumption in Preschoolers from Six European Countries: The ToyBox-Study

    Science.gov (United States)

    Pinket, An-Sofie; Van Lippevelde, Wendy; De Bourdeaudhuij, Ilse; Deforche, Benedicte; Cardon, Greet; Androutsos, Odysseas; Koletzko, Berthold; Moreno, Luis A.; Socha, Piotr; Iotova, Violeta; Manios, Yannis; De Craemer, Marieke

    2016-01-01

    Background Within the ToyBox-study, a kindergarten-based, family-involved intervention was developed to prevent overweight and obesity in European preschoolers, targeting four key behaviours related to early childhood obesity, including water consumption. The present study aimed to examine the effect of the ToyBox-intervention (cluster randomized controlled trial) on water intake and beverage consumption in European preschoolers and to investigate if the intervention effects differed by implementation score of kindergartens and parents/caregivers. Method A sample of 4964 preschoolers (4.7±0.4 years; 51.5% boys) from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain) was included in the data analyses. A standardized protocol was used and parents/caregivers filled in socio-demographic data and a food-frequency questionnaire. To assess intervention effects, multilevel repeated measures analyses were conducted for the total sample and for the six country-specific samples. Based on the process evaluation questionnaire of teachers and parents/caregivers, an implementation score was constructed. To assess differences in water intake and beverage consumption by implementation score in the total sample, multilevel repeated measures analyses were performed. Results Limited intervention effects on water intake from beverages and overall beverage consumption were found. However, important results were found on prepacked fruit juice consumption, with a larger decrease in the intervention group compared to the control group. However, also a decline in plain milk consumption was found. Implementation scores were rather low in both kindergartens and parents/caregivers. Nevertheless, more favorable effects on beverage choices were found in preschoolers whose parents/caregivers and kindergarten teachers had higher implementation scores compared to those with lower implementation scores. Conclusion The ToyBox-intervention can provide the basis for the

  3. Optimizing PHB and Protease Production by Box Behnken Design

    Directory of Open Access Journals (Sweden)

    Amro Abd al fattah Amara

    2013-04-01

    Full Text Available Mixed culture is more suitable to adapt more flexible fermentation process and produce different product simultaneously. In this study a mixed Bacillus culture was investigated for their ability to produce the bioplastic "Polyhydroxybutyrate" and both of the mesophilic and the thermophilic proteases in one flask. Box-Behnken experimental design was used. The produced amount of PHB has been increased significantly. Meanwhile there is a competition between PHB and proteases. The maximum produced amount of PHB using Box-Behnken design was 2.82 g/l/48 h with protease activity equal to 41.9 Units/ml/48 h for thermophilic proteases and 99.65 Units/ml/48 h for mesophilic proteases. Excel solver was used for extra-optimization for the optimum conditions obtained from Box-Behnken experiments and its model. The maximum PHB obtained after using Excel solver was 2.88 g/l/48 h. The maximum mesophilic and thermophilic activities obtained at the same PHB production conditions were 175.68 and 243.38 Units/ml respectively. The model accuracy as obtained from Excel solver was 118.8%, which prove the power of the experimental design in optimizing such complicated process. The strategies used in this study are recommended for the production of PHB and different proteases simultaneously using Bacillus mixed culture. ABSTRAK: Kultur campuran adalah lebih sesuai bagi proses penapaian yang fleksibel dan ia boleh menghasilkan produk yang berbeza secara serentak. Dalam kajian ini keupayaan  menghasilkan "Polyhydroxybutyrate" bioplastik serta mesofilik dan termofilik protease dalam satu flask oleh  kultur Bacillus campuran telah disiasat. Eksperimen rekabentuk Box-Behnken telah digunakan. Jumlah PHB yang dikeluarkan meningkat dengan ketara dan terdapat persaingan antara PHB dan protease. Jumlah keluaran PHB maksima menggunakan rekabentuk Box-Behnken adalah 2.82 g/l/48 jam dengan aktiviti protease sama dengan 41.9 Unit/ml/48 jam untuk protease termofilik dan 99.65 Unit

  4. Box-modeling of the impacts of atmospheric nitrogen deposition and benthic remineralization on the nitrogen cycle of the eastern tropical South Pacific

    Science.gov (United States)

    Su, B.; Pahlow, M.; Oschlies, A.

    2015-09-01

    Both atmospheric deposition and benthic remineralization influence the marine nitrogen cycle, and hence ultimately also marine primary production. The biological and biogeochemical relations of the eastern tropical South Pacific (ETSP) to nitrogen deposition, benthic denitrification and phosphate regeneration are analysed in a prognostic box model of the oxygen, nitrogen and phosphorus cycles in the ETSP. In the model, atmospheric nitrogen deposition based on estimates for the years 2000-2009 is offset by half by reduced N2 fixation, with the other half transported out of the model domain. Both model- and data-based benthic denitrification are found to trigger nitrogen fixation, partly compensating for the NO3- loss. Since phosphate is the ultimate limiting nutrient in the model, enhanced sedimentary phosphate regeneration under suboxic conditions stimulates primary production and subsequent export production and NO3- loss in the oxygen minimum zone (OMZ). A sensitivity analysis of the local response to both atmospheric deposition and benthic remineralization indicates dominant stabilizing feedbacks in the ETSP, which tend to keep a balanced nitrogen inventory, i.e., nitrogen input by atmospheric deposition is counteracted by decreasing nitrogen fixation; NO3- loss via benthic denitrification is partly compensated by increased nitrogen fixation; enhanced nitrogen fixation stimulated by phosphate regeneration is partly removed by the stronger water-column denitrification. Even though the water column in our model domain acts as a NO3- source, the ETSP including benthic denitrification might become a NO3- sink.

  5. Box-modeling of the impacts of atmospheric nitrogen deposition and benthic remineralization on the nitrogen cycle of the eastern tropical South Pacific

    Directory of Open Access Journals (Sweden)

    B. Su

    2015-09-01

    Full Text Available Both atmospheric deposition and benthic remineralization influence the marine nitrogen cycle, and hence ultimately also marine primary production. The biological and biogeochemical relations of the eastern tropical South Pacific (ETSP to nitrogen deposition, benthic denitrification and phosphate regeneration are analysed in a prognostic box model of the oxygen, nitrogen and phosphorus cycles in the ETSP. In the model, atmospheric nitrogen deposition based on estimates for the years 2000–2009 is offset by half by reduced N2 fixation, with the other half transported out of the model domain. Both model- and data-based benthic denitrification are found to trigger nitrogen fixation, partly compensating for the NO3− loss. Since phosphate is the ultimate limiting nutrient in the model, enhanced sedimentary phosphate regeneration under suboxic conditions stimulates primary production and subsequent export production and NO3− loss in the oxygen minimum zone (OMZ. A sensitivity analysis of the local response to both atmospheric deposition and benthic remineralization indicates dominant stabilizing feedbacks in the ETSP, which tend to keep a balanced nitrogen inventory, i.e., nitrogen input by atmospheric deposition is counteracted by decreasing nitrogen fixation; NO3− loss via benthic denitrification is partly compensated by increased nitrogen fixation; enhanced nitrogen fixation stimulated by phosphate regeneration is partly removed by the stronger water-column denitrification. Even though the water column in our model domain acts as a NO3− source, the ETSP including benthic denitrification might become a NO3− sink.

  6. Do mirror glasses have the same effect on brain activity as a mirror box? Evidence from a functional magnetic resonance imaging study with healthy subjects.

    Directory of Open Access Journals (Sweden)

    Christopher Milde

    Full Text Available Since its original proposal, mirror therapy has been established as a successful neurorehabilitative intervention in several neurological disorders to recover motor function or to relieve pain. Mirror therapy seems to operate by reactivating the contralesional representation of the non-mirrored limb in primary motor- and somatosensory cortex. However, mirror boxes have some limitations which prompted the use of additional mirror visual feedback devices. The present study evaluated the utility of mirror glasses compared to a mirror box. We also tested the hypothesis that increased interhemispheric communication between the motor hand areas is the mechanism by which mirror visual feedback recruits the representation of the non-mirrored limb. Therefore, mirror illusion capacity and brain activations were measured in a within-subject design during both mirror visual feedback conditions in counterbalanced order with 20 healthy subjects inside a magnetic resonance imaging scanner. Furthermore, we analyzed task-dependent functional connectivity between motor hand representations using psychophysiological interaction analysis during both mirror tasks. Neither the subjective quality of mirror illusions nor the patterns of functional brain activation differed between the mirror tasks. The sensorimotor representation of the non-mirrored hand was recruited in both mirror tasks. However, a significant increase in interhemispheric connectivity between the hand areas was only observed in the mirror glasses condition, suggesting different mechanisms for the recruitment of the representation of the non-mirrored hand in the two mirror tasks. We conclude that the mirror glasses might be a promising alternative to the mirror box, as they induce similar patterns of brain activation. Moreover, the mirror glasses can be easy applied in therapy and research. We want to emphasize that the neuronal mechanisms for the recruitment of the affected limb representation might

  7. Opto-Box

    CERN Document Server

    Bertsche, David; The ATLAS collaboration; Welch, Steven; Smith, Dale Shane; Che, Siinn; Gan, K.K.; Boyd, George Russell Jr

    2015-01-01

    The opto-box is a custom mini-crate for housing optical modules, which process and transfer optoelectronic data. The system tightly integrates electrical, mechanical, and thermal functionality into a small package of size 35x10x8 cm^3. Special attention was given to ensure proper shielding, grounding, cooling, high reliability, and environmental tolerance. The custom modules, which incorporate Application Specific Integrated Circuits (ASICs), were developed through a cycle of rigorous testing and redesign. In total, fourteen opto-boxes have been installed and loaded with modules on the ATLAS detector. They are currently in operation as part of the LHC run 2 data read-out chain.

  8. Structure and biochemical function of a prototypical Arabidopsis U-box domain

    DEFF Research Database (Denmark)

    Andersen, Pernille; Kragelund, Birthe B; Olsen, Addie N;

    2004-01-01

    corresponding to zinc ion-coordinating residues in RING domains. Residues from a C-terminal alpha-helix interact with the core domain and contribute to stabilization. The Prp19p U-box lacks a corresponding C-terminal alpha-helix. Chemical shift analysis suggested that aromatic residues exposed at the N terminus...... and the C-terminal alpha-helix of the AtPUB14 U-box participate in dimerization. Thus, AtPUB14 may form a biologically relevant dimer. This is the first plant U-box structure to be determined, and it provides a model for studies of the many plant U-box proteins and their interactions. Structural insight...... into these interactions is important, because ubiquitin-dependent protein degradation is a prevalent regulatory mechanism in plants....

  9. Hydrophobic, Porous Battery Boxes

    Science.gov (United States)

    Bragg, Bobby J.; Casey, John E., Jr.

    1995-01-01

    Boxes made of porous, hydrophobic polymers developed to contain aqueous potassium hydroxide electrolyte solutions of zinc/air batteries while allowing air to diffuse in as needed for operation. Used on other types of batteries for in-cabin use in which electrolytes aqueous and from which gases generated during operation must be vented without allowing electrolytes to leak out.

  10. Glove box posting system

    International Nuclear Information System (INIS)

    A system for posting objects into closed containers, such as glove boxes, is described in which the bag used, preferably made of plastic, does not have to be fitted and sealed by the operator during each posting operation. (U.K.)

  11. Cereal Box Totems.

    Science.gov (United States)

    Jones, AnnMarie

    2002-01-01

    Presents a multicultural project used with fourth-grade students in which they created a three-dimensional totem pole using leftover cereal boxes. Discusses in detail how to create the totem pole. Explains that students learned about Northwest American Indians in class. (CMK)

  12. Energy Savings Assessment for Digital-to-Analog Converter Boxes

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Hoi Ying Iris; Meier, Alan; Brown, Richard

    2011-01-18

    The Digital Television (DTV) Converter Box Coupon Program was administered by the U.S. government to subsidize purchases of digital-to-analog converter boxes, with up to two $40 coupons for each eligible household. In order to qualify as Coupon Eligible Converter Boxes (CECBs), these devices had to meet a number of minimum performance specifications, including energy efficiency standards. The Energy Star Program also established voluntary energy efficiency specifications that are more stringent than the CECB requirements. In this study, we measured the power and energy consumptions for a sample of 12 CECBs (including 6 Energy Star labeled models) in-use in homes and estimated aggregate energy savings produced by the energy efficiency policies. Based on the 35 million coupons redeemed through the end of the program, our analysis indicates that between 2500 and 3700 GWh per year are saved as a result of the energy efficiency policies implemented on digital-to-analog converter boxes. The energy savings generated are equivalent to the annual electricity use of 280,000 average US homes.

  13. Combined application of black box models to environmental tracer data for determination of transport and hydraulic parameters in karstic aquifer of Schneealpe (Austria)

    International Nuclear Information System (INIS)

    The Schneealpe karst massif of Triassic limestones and dolomites with the altitude up to 1800 m a.s.l., situated 100 km SW of Vienna in Kalkalpen, is the main drinking water resource for the city. The catchment area of about 23 km2 is drained by two springs: Wasseralmquelle (200 L/s) and Siebenquellen (310 L/s). This karstic aquifer is approximated by two interconnected parallel flow systems of: (a) a fissured-porous aquifer, and (b) karstic channels. The fissured-porous aquifer is of a high storage capacity and contains mobile water in the fissures and stagnant water in the porous matrix. The water enters this system at the surface and flows through it to the drainage channels, which are regarded as a separate flow system, finally drained by both springs. The channels are also connected with sinkholes, which introduce additional water directly from the surface. The measurements of 18O and tritium in precipitation (input functions) and springs (residence time distribution functions) were modelled by a combined application of black-box models. The modelling was performed for different hydraulic conditions, i.e., high and low discharges separately. It has yielded the information on the mean water volume in the whole catchment area and in both systems (channels and fissured-porous aquifer) as well as the volumetric flow rates through these systems and amount of water flowing directly to the springs from the sinkholes. (author)

  14. Evaluation of probabilistic flow predictions in sewer systems using grey box models and a skill score criterion

    DEFF Research Database (Denmark)

    Thordarson, Fannar Ørn; Breinholt, Anders; Møller, Jan Kloppenborg;

    2012-01-01

    term and a diffusion term, respectively accounting for the deterministic and stochastic part of the models. Furthermore, a distinction is made between the process noise and the observation noise. We compare five different model candidates’ predictive performances that solely differ with respect to the...... diffusion term description up to a 4 h prediction horizon by adopting the prediction performance measures; reliability, sharpness and skill score to pinpoint the preferred model. The prediction performance of a model is reliable if the observed coverage of the prediction intervals corresponds to the nominal...

  15. Dynamic Analysis of Horizontally Curved Thin-Walled Box-Girder Bridge due to Moving Vehicle

    Directory of Open Access Journals (Sweden)

    K. Nallasivam

    2007-01-01

    Full Text Available The impact on curved box-girder bridges due to vehicle moving across rough bridge deck have been analyzed using bridge-vehicle coupled dynamics. The bridge deck unevenness has been assumed to be a homogeneous random process in space specified by a PSD function. The analysis incorporates the effect of centrifugal forces due to vehicle moving on curved bridge. The curved box-girder bridge has been numerically modeled using computationally efficient thin-walled box-beam finite elements which take into account the torsional warping, distortion and distortional warping, that are important features of thin-walled box girders. Rigid vehicle with longitudinal and transverse input to the wheels giving rise to heave-pitch-roll degrees of freedom has been considered. The theoretical bridge model used in simulation study has been validated by a free vibration experiment using impact excitation. The impact factors for several response parameters such as bending moment, shear force, torsional moment, torsional bi-moment, distortional moment, distortional bi-moment and vertical deflections have been obtained for various bridge-vehicle parameters. Both constant velocity and forward acceleration of the vehicle have been considered to examine impact factor. The results highlighted that the impact factors of a curved box girder bridge corresponding to torsion, distortion and their corresponding bimoments have been observed to be generally very high, while those of the other responses are also relatively higher than that of corresponding straight box girder bridge.

  16. Implications of Big Box Retail Location on Regional Profits, Consumer Utility, and Land Rents

    OpenAIRE

    Stater, Mark; Visser, Michael S.

    2008-01-01

    This paper uses a monocentric city model to examine the effects of big box retailing on local retail prices, land values and utility. Relative to small local retailers, the big box offers a price discount that increases in its marginal cost advantage. Big box entry reduces local retail prices and profits, but provides an increase in household utility that depends positively on the distance between the big box location and the CBD. However, big box locations are unstable with imperfectly compe...

  17. Decommissioning a small glove box

    International Nuclear Information System (INIS)

    An account is given of dismantling a fuel fabrication glove box using simple tooling. The fissile content of the box was first measured by several non-destructive techniques. After cleaning, the box was dismantled using hand tools and finally packed for disposal. A record of operator radiation doses, the time taken for each stage of the operation and packing information is given. (author)

  18. HYDROGEN AND VOC RETENTION IN WASTE BOXES

    Energy Technology Data Exchange (ETDEWEB)

    PACE ME; MARUSICH RM

    2008-11-21

    The Hanford Waste Management Project Master Documented Safety Analysis (MDSA) (HNF-14741, 2003) identifies derived safety controls to prevent or mitigate the risks of a single-container deflagration during operations requiring moving, venting or opening transuranic (TRU)-waste containers. The issue is whether these safety controls are necessary for operations involving TRU-waste boxes that are being retrieved from burial at the Hanford Site. This paper investigates the potential for a deflagration hazard within these boxes and whether safety controls identified for drum deflagration hazards should be applied to operations involving these boxes. The study evaluates the accumulation of hydrogen and VOCs within the waste box and the transport of these gases and vapors out of the waste box. To perform the analysis, there were numerous and major assumptions made regarding the generation rate and the transport pathway dimensions and their number. Since there is little actual data with regards to these assumptions, analyses of three potential configurations were performed to obtain some indication of the bounds of the issue (the concentration of hydrogen or flammable VOCs within a waste box). A brief description of each of the three cases along with the results of the analysis is summarized.

  19. Opto-Box

    CERN Document Server

    Bertsche, David; The ATLAS collaboration

    2015-01-01

    The opto-box is a custom mini-crate for housing optical modules, which process and transfer optoelectronic data. Many novel solutions were developed for the custom design and manufacturing. The system tightly integrates electrical, mechanical, and thermal functionality into a small package of size 35x10x8 cm$^{3}$. Special attention was given to ensure proper shielding, grounding, cooling, high reliability, and environmental tolerance. The custom modules, which incorporate Application Specific Integrated Circuits (ASICs), were developed through a cycle of rigorous testing and redesign. In total, fourteen opto-boxes have been installed and loaded with modules on the ATLAS detector. They are currently in operation as part of the LHC run 2 data read-out chain.

  20. The Box Method

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm

    The velocity level in a room ventilated by jet ventilation is strongly influenced by the supply conditions. The momentum flow in the supply jets controls the air movement in the room and, therefore, it is very important that the inlet conditions and the numerical method can generate a satisfactor...... description of this momentum flow. The Box Method is a practical method for the description of an Air Terminal Device which will save grid points and ensure the right level of the momentum flow....

  1. Learning with box kernels.

    Science.gov (United States)

    Melacci, Stefano; Gori, Marco

    2013-11-01

    Supervised examples and prior knowledge on regions of the input space have been profitably integrated in kernel machines to improve the performance of classifiers in different real-world contexts. The proposed solutions, which rely on the unified supervision of points and sets, have been mostly based on specific optimization schemes in which, as usual, the kernel function operates on points only. In this paper, arguments from variational calculus are used to support the choice of a special class of kernels, referred to as box kernels, which emerges directly from the choice of the kernel function associated with a regularization operator. It is proven that there is no need to search for kernels to incorporate the structure deriving from the supervision of regions of the input space, because the optimal kernel arises as a consequence of the chosen regularization operator. Although most of the given results hold for sets, we focus attention on boxes, whose labeling is associated with their propositional description. Based on different assumptions, some representer theorems are given that dictate the structure of the solution in terms of box kernel expansion. Successful results are given for problems of medical diagnosis, image, and text categorization. PMID:24051728

  2. Grey-box Modelling of a Household Refrigeration Unit Using Time Series Data in Application to Demand Side Management

    DEFF Research Database (Denmark)

    Sossan, Fabrizio; Lakshmanan, Venkatachalam; Costanzo, Giuseppe Tommaso;

    2016-01-01

    ) to shift the electricity consumption of a freezer in demand response experiments, thereby addressing the model selection problem also from the application point of view and showing in an experimental context the ability of MPC to exploit the freezer as a demand side resource (DSR)....

  3. The analytic solution of the firm's cost-minimization problem with box constraints and the Cobb-Douglas model

    Science.gov (United States)

    Bayón, L.; Grau, J. M.; Ruiz, M. M.; Suárez, P. M.

    2012-12-01

    One of the most well-known problems in the field of Microeconomics is the Firm's Cost-Minimization Problem. In this paper we establish the analytical expression for the cost function using the Cobb-Douglas model and considering maximum constraints for the inputs. Moreover we prove that it belongs to the class C1.

  4. A Comprehensive Study of Neutralizing Antigenic Sites on the Hepatitis E Virus (HEV) Capsid by Constructing, Clustering, and Characterizing a Tool Box.

    Science.gov (United States)

    Zhao, Min; Li, Xiao-Jing; Tang, Zi-Min; Yang, Fan; Wang, Si-Ling; Cai, Wei; Zhang, Ke; Xia, Ning-Shao; Zheng, Zi-Zheng

    2015-08-01

    The hepatitis E virus (HEV) ORF2 encodes a single structural capsid protein. The E2s domain (amino acids 459-606) of the capsid protein has been identified as the major immune target. All identified neutralizing epitopes are located on this domain; however, a comprehensive characterization of antigenic sites on the domain is lacking due to its high degree of conformation dependence. Here, we used the statistical software SPSS to analyze cELISA (competitive ELISA) data to classify monoclonal antibodies (mAbs), which recognized conformational epitopes on E2s domain. Using this novel analysis method, we identified various conformational mAbs that recognized the E2s domain. These mAbs were distributed into 6 independent groups, suggesting the presence of at least 6 epitopes. Twelve representative mAbs covering the six groups were selected as a tool box to further map functional antigenic sites on the E2s domain. By combining functional and location information of the 12 representative mAbs, this study provided a complete picture of potential neutralizing epitope regions and immune-dominant determinants on E2s domain. One epitope region is located on top of the E2s domain close to the monomer interface; the other is located on the monomer side of the E2s dimer around the groove zone. Besides, two non-neutralizing epitopes were also identified on E2s domain that did not stimulate neutralizing antibodies. Our results help further the understanding of protective mechanisms induced by the HEV vaccine. Furthermore, the tool box with 12 representative mAbs will be useful for studying the HEV infection process. PMID:26085097

  5. EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL.

    Science.gov (United States)

    Hausmann, Jennifer C; Wack, Allison N; Allender, Matthew C; Cranfield, Mike R; Murphy, Kevin J; Barrett, Kevin; Romero, Jennell L; Wellehan, James F X; Blum, Stella A; Zink, M Christine; Bronson, Ellen

    2015-12-01

    The Maryland Zoo in Baltimore experienced an outbreak of Frog virus-3 (FV3)-like ranavirus during the summer of 2011, during which 14 of 27 (52%) of its captive eastern box turtles (Terrapene carolina carolina) survived. To assess survival, immunity, and viral shedding, an experimental challenge study was performed in which the surviving, previously infected turtles were reinfected with the outbreak strain of FV3-like ranavirus. Seven turtles were inoculated with virus intramuscularly and four control turtles received saline intramuscularly. The turtles were monitored for 8 wk with blood and oral swabs collected for quantitative polymerase chain reaction (qPCR). During that time, one of seven (14%) inoculated turtles and none of the controls (0%) died; there was no significant difference in survival. Clinical signs of the inoculated turtles, except for the turtle that died, were mild compared to the original outbreak. Quantitative PCR for FV3-like ranavirus on blood and oral swabs was positive for all inoculated turtles and negative for all controls. The turtle that died had intracytoplasmic inclusion bodies in multiple organs. Three inoculated and two control turtles were euthanized at the end of the study. No inclusion bodies were present in any of the organs. Quantitative PCR detected FV3-like ranavirus in the spleen of a control turtle, which suggested persistence of the virus. The surviving five turtles were qPCR-negative for FV3-like ranavirus from blood and oral swabs after brumation. Quantitative PCR for Terrapene herpesvirus 1 found no association between ranavirus infection and herpesvirus loads. In conclusion, previously infected eastern box turtles can be reinfected with the same strain of FV3-like ranavirus and show mild to no clinical signs but can shed the virus from the oral cavity. PMID:26667529

  6. Investigating Differences in Isoprene Oxidation Chemistry Between Gas-Phase Mechanisms Using a Constrained Chemical Box Model

    Science.gov (United States)

    Marvin, M. R.; Wolfe, G. M.; Salawitch, R. J.; Canty, T. P.; Hanisco, T. F.; Kaiser, J.; Keutsch, F. N.; Graus, M.; Warneke, C.; De Gouw, J. A.; Gilman, J.; Lerner, B. M.; Peischl, J.; Veres, P. R.; Min, K. E.; Holloway, J. S.; Aikin, K. C.; Ryerson, T. B.; Roberts, J. M.; Brown, S. S.; Pollack, I. B.; Hatch, C. D.; Lee, B. H.; Lopez-Hilfiker, F.; Thornton, J. A.; Diskin, G. S.; Sachse, G. W.; Huey, L. G.; Liu, X.; Wisthaler, A.; Mikoviny, T.; Wennberg, P. O.; St Clair, J.; Crounse, J.; Teng, A.

    2015-12-01

    Oxidation of isoprene by OH can significantly influence concentrations of important atmospheric pollutants such as ozone and secondary organic aerosols, but the chemistry that describes the relationships between these species is complex and not fully understood. Debate on the topic has led to differences in the isoprene oxidation schemes of several gas-phase chemical mechanisms currently applied in air chemistry models. We use the University of Washington Chemical Model (UWCMv3) to evaluate these mechanisms with respect to isoprene chemistry based on observations from the SENEX and SEAC4RS aircraft campaigns. The campaigns provide constraints on compounds measured over the Southeast United States, where isoprene concentrations are high and other conditions (e.g., NOx levels) vary widely. The payloads for both missions include observations of a wide range of isoprene oxidation products, which can provide insight into specific oxidation pathways. Analysis will focus on the characterization and comparison of isoprene oxidation chemistry for established gas-phase mechanisms that are prevalent in atmospheric modeling today, including the Carbon Bond mechanism (CB05 and CB6r2) and the Master Chemical Mechanism (versions 3.2 and 3.3).

  7. Determination of deep water circulation in the East Atlantic Ocean by means of a box-model based evaluation of C-14 measurements and other tracer data

    International Nuclear Information System (INIS)

    Radiocarbon (C-14) measurements proved to be an efficient means of determining the average, large-area deep water circulation in the Atlantic Ocean. The thesis under review explains and discusses measurements carried out in the equatorial West Atlantic and North Atlantic Ocean. The samples have been taken during mission 56 of the RS 'meteor' in spring 1981. The gas has been obtained by vacuum extraction and the measurements have been performed in proportional counter tubes, the error to be accounted for amounting to 2per mille. These measured data, together with measurements of the potential temperatures, the silicate and CO2 concentrations, and measured data from the South-East Atlantic Ocean, have been used to calculate on the basis of a box model of the Atlantic Ocean the deep water flow from the West to the East Atlantic Ocean, the deep water circulation between the various East Atlantic basins, and the turbulent diffusion coefficients required to parameterize the deep water mixing processes. (orig./HP)

  8. Concepts and strategies on how to train and motivate teachers to implement a kindergarten-based, family-involved intervention to prevent obesity in early childhood. The ToyBox-study.

    Science.gov (United States)

    Payr, A; Birnbaum, J; Wildgruber, A; Kreichauf, S; Androutsos, O; Lateva, M; De Decker, E; De Craemer, M; Iotova, V; Manios, Y; Koletzko, B

    2014-08-01

    The key person for the implementation of kindergarten-based behavioural interventions is the kindergarten teacher. When conducting intervention studies in kindergartens, training sessions are needed to train and motivate kindergarten teachers for programme implementation. This paper presents the systematic development of the teachers' trainings executed in the ToyBox-intervention - a kindergarten-based and family-involved obesity prevention programme for children aged 4-6. Based on concepts for the education of kindergarten teachers, on general strategies for successful programme implementation and on the ToyBox programme-specific requirements, the aims of the teachers' trainings were defined and an overall concept was deduced. Regarding the concept for the ToyBox teachers' training sessions, it is concluded that the training modules should focus on presenting information on the practical implementation of the intervention. Furthermore, these modules should also include self-efficacy enhancing components and should give kindergarten teachers opportunities to share experiences. Regarding the didactic methods applied in the ToyBox teachers' training sessions, constructivist learning approaches that facilitate active participation, reflective thinking and personal involvement were implemented. Emphasis was put not only on the content but especially on the didactic methods of teachers' trainings in order to enhance devotion to, and quality and sustainability of the ToyBox-intervention. PMID:25047377

  9. Rates and regimes of photochemical ozone production over Central East China in June 2006: a box model analysis using comprehensive measurements of ozone precursors

    Directory of Open Access Journals (Sweden)

    Y. Kanaya

    2009-10-01

    Full Text Available An observation-based box model approach was undertaken to estimate concentrations of OH, HO2, and RO2 radicals and the net photochemical production rate of ozone at the top of Mount Tai, located in the middle of Central East China, in June 2006. The model calculation was constrained by the measurements of O3, H2O, CO, NO, NO2, hydrocarbon, HCHO, and CH3CHO concentrations, and temperature and J values. The net production rate of ozone was estimated to be 6.4 ppb h−1 as a 6-h average (09:00–15:00 CST, suggesting 58±37 ppb of ozone is produced in one day. Thus the daytime buildup of ozone recorded at the mountain top as ~23 ppb on average is likely affected by in situ photochemistry as well as by the upward transport of polluted air mass in the daytime. On days with high ozone concentrations (hourly values exceeding 100 ppb at least once, in situ photochemistry was more active than it was on low ozone days, suggesting that in situ photochemistry is an important factor controlling ozone concentrations. Sensitivity model runs for which different NOx and hydrocarbon concentrations were assumed suggested that the ozone production occurred normally under NOx-limited conditions, with some exceptional periods (under volatile-organic-compound-limited conditions in which there was fresh pollution. We also examined the possible influence of the heterogeneous loss of gaseous HO2 radicals in contact with aerosol particle surfaces on the rate and regimes of ozone production.

  10. A box model of the Late Miocene Mediterranean Sea: implications from combined 87Sr/86Sr and salinity data

    OpenAIRE

    R. P. M. Topper; R. Flecker; Meijer, P.Th.; M. J. R. Wortel

    2011-01-01

    Under certain conditions the strontium isotope ratio in the water of a semi‐enclosed basin is known to be sensitive to the relative size of ocean water inflow and river input. Combining Sr‐isotope ratios measured in Mediterranean Late Miocene successions with data on past salinity, one can derive quantitative information on the Mediterranean hydrological budget at times before and during the Messinian Salinity Crisis (MSC). Previous studies obtained this hydrological budget by inverting the s...

  11. Three Essays on Big-Box Retailers and Regional Economics

    OpenAIRE

    Peralta, Denis

    2016-01-01

    The big-box retail stores such as Wal-Mart and Target have become the focus of many studies researching their impacts on local economic outcomes. This dissertation studies three related topics: (i) the dynamic interrelationship among the presence of the big-box stores, retail wage, and employment, (ii) the impact of the big-box retailers on personal income growth, and (iii) the dynamic interrelationship between the presence of big-box retailers and personal income growth. The research draws i...

  12. Simultaneous lidar observations of a polar stratospheric cloud on the east and west sides of the Scandinavian mountains and microphysical box model simulations

    Directory of Open Access Journals (Sweden)

    U. Blum

    2006-12-01

    Full Text Available The importance of polar stratospheric clouds (PSC for polar ozone depletion is well established. Lidar experiments are well suited to observe and classify polar stratospheric clouds. On 5 January 2005 a PSC was observed simultaneously on the east and west sides of the Scandinavian mountains by ground-based lidars. This cloud was composed of liquid particles with a mixture of solid particles in the upper part of the cloud. Multi-colour measurements revealed that the liquid particles had a mode radius of r≈300 nm, a distribution width of σ≈1.04 and an altitude dependent number density of N≈2–20 cm−3. Simulations with a microphysical box model show that the cloud had formed about 20 h before observation. High HNO3 concentrations in the PSC of 40–50 weight percent were simulated in the altitude regions where the liquid particles were observed, while this concentration was reduced to about 10 weight percent in that part of the cloud where a mixture between solid and liquid particles was observed by the lidar. The model simulations also revealed a very narrow particle size distribution with values similar to the lidar observations. Below and above the cloud almost no HNO3 uptake was simulated. Although the PSC shows distinct wave signatures, no gravity wave activity was observed in the temperature profiles measured by the lidars and meteorological analyses support this observation. The observed cloud must have formed in a wave field above Iceland about 20 h prior to the measurements and the cloud wave pattern was advected by the background wind to Scandinavia. In this wave field above Iceland temperatures potentially dropped below the ice formation temperature, so that ice clouds may have formed which can act as condensation nuclei for the nitric acid trihydrate (NAT particles observed at the cloud top above Esrange.

  13. Faster Black-Box Algorithms Through Higher Arity Operators

    DEFF Research Database (Denmark)

    Doerr, Benjamin; Johannsen, Daniel; Kötzing, Timo; Lehre, Per Kristian; Wagner, Markus; Winzen, Carola

    We extend the work of Lehre and Witt (GECCO 2010) on the unbiased black-box model by considering higher arity variation operators. In particular, we show that already for binary operators the black-box complexity of LeadingOnes drops from (n2) for unary operators to O(n log n). For OneMax, the (n...

  14. Projection optics box

    Science.gov (United States)

    Hale, Layton C.; Malsbury, Terry; Hudyma, Russell M.; Parker, John M.

    2000-01-01

    A projection optics box or assembly for use in an optical assembly, such as in an extreme ultraviolet lithography (EUVL) system using 10-14 nm soft x-ray photons. The projection optics box utilizes a plurality of highly reflective optics or mirrors, each mounted on a precision actuator, and which reflects an optical image, such as from a mask, in the EUVL system onto a point of use, such as a target or silicon wafer, the mask, for example, receiving an optical signal from a source assembly, such as a developed from laser system, via a series of highly reflective mirrors of the EUVL system. The plurality of highly reflective optics or mirrors are mounted in a housing assembly comprised of a series of bulkheads having wall members secured together to form a unit construction of maximum rigidity. Due to the precision actuators, the mirrors must be positioned precisely and remotely in tip, tilt, and piston (three degrees of freedom), while also providing exact constraint.

  15. Forkhead box A1 (FOXA1) tagging polymorphisms and esophageal cancer risk in a Chinese population: a fine-mapping study.

    Science.gov (United States)

    Li, Mingna; Zhang, Wenbo; Liu, Chao; Shi, Yijun; Tang, Weifeng; Chen, Suocheng; Gu, Haiyong; Yin, Jun; Zhang, Zhihong; Jiang, Pengcheng

    2016-09-01

    Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of esophageal cancers. Besides environmental risk factors, genetic factors such as single-nucleotide polymorphisms (SNPs) play an important role in ESCC carcinogenesis. We performed a hospital-based case-control study to evaluate the Forkhead-box protein A1 (FOXA1) rs12894364 C > T, rs2145146 C > A and rs7144658 T > C tag SNPs in the risk of developing ESCC. We recruited 629 ESCC cases and 686 controls. Genotypes were determined using ligation detection reaction. Logistic regression analyses revealed that the three FOXA1 SNPs were not associated with ESCC risk. However, there was significantly decreased ESCC risk associated with the FOXA1 rs12894364 C > T and rs2145146 C > A polymorphisms among older patients. There was significantly increased ESCC risk associated with the FOXA1 rs7144658 T > C polymorphism among male patients. This study demonstrates an association between FOXA1 polymorphisms and ESCC susceptibility. Additional larger studies are required to confirm our findings. PMID:27050876

  16. On the hydroelastic response of box-shaped floating structure with shallow draft. Tank test with large scale model; Senkitsusui hakogata futai no harochu dansei oto ni tsuite. Ogata mokei ni yoru suiso shiken

    Energy Technology Data Exchange (ETDEWEB)

    Yago, K.; Endo, H. [Ship Research Inst., Tokyo (Japan)

    1996-12-31

    The hydroelastic response test was carried out in waves using an approximately 10m long large model, and the numerical analysis was done by the direct method, for a commercial-size (300m long) box-shaped floating structure with shallow draft. The scale ratio of the model is 1/30.8, and the minimum wave cycle is around 0.7s from wave-making capacity of the tank, which corresponds to 4 to 14s with the commercial-size structure. Elastic displacement and bending strain were measured. The calculated results by the direct method are in good agreement with the observed results. The fluid dynamic mutual interference effects between elements are weak in added mass but strong in damping force, indicating that the range of mutual interference is strongly related to rolling cycle in the range of mutual interference. Wave pressure on the floating structure bottom is high at the upper side of the wave, greatly damping towards the downside of the wave. However, response amplitude of elastic displacement tends to increase at the ends, both in upside and downside of the wave. For the floating structure studied, the 0 to 4th mode components are predominant in longitudinal waves, and the 6th or higher mode components are negligibly low. 21 refs., 15 figs., 2 tabs.

  17. Glove-box filters

    International Nuclear Information System (INIS)

    Description is given of a device for simply and rapidly assembling and dissassembling the filters used inside sealed enclosures, such as glove-boxes and shielded cells equipped with nippers or manipulators, said filters being of the type comprising a cylindrical casing containing a filtering member, the upper portion of said casing being open so as to allow the gases to be cleaned to flow in, whereas the casing bottom is centrally provided with a hole extended outwardly by a threaded collar on which is screwed a connecting-sleeve to be fixed to the mouth of a gas outlet pipe. To a yoke transverse bar is welded a pin which can be likened to a bent spring-blade, one arm of which welded to said transverse bar, is rectilinear whereas its other arm is provided with a boss cooperating with a cavity made in a protrusion of said pipe, right under the mouth thereof

  18. ACSYS in a box

    CERN Document Server

    Briegel, C; Hendricks, B; King, C; Lackey, S; Neswold, R; Nicklaus, D; Patrick, J; Petrov, A; Rechenmacher, R; Schumann, C; Smedinghoff, J

    2012-01-01

    The Accelerator Control System at Fermilab has evolved to enable this relatively large control system to be encapsulated into a "box" such as a laptop. The goal was to provide a platform isolated from the "online" control system. This platform can be used internally for making major upgrades and modifications without impacting operations. It also provides a standalone environment for research and development including a turnkey control system for collaborators. Over time, the code base running on Scientific Linux has enabled all the salient features of the Fermilab's control system to be captured in an off-the-shelf laptop. The anticipated additional benefits of packaging the system include improved maintenance, reliability, documentation, and future enhancements.

  19. Determination of pharmacokinetic processes in body organs on the basis of the box model and, by analogy, of laws of radioactive disintegration of naturally occurring and artificially activated isotope families

    International Nuclear Information System (INIS)

    The research work described is based on the simple law of degradation and disintegration for pharmaceutical substances. The transport, storage and, possibly, accumulation of beneficial and harmful pharmaceuticals in the organs of the human body are analysed using the box model. The studies are not restricted to asymptotic conditions occurring after continuous treatment with a particular drug but also investigate into the so-called stabilisation phase immediately after the beginning of medication, which is described mathematically. This phase is shown to be subject to a set of rules that are much more complex than those responsible for asymptotic substance levels. The analytical procedures used here are described on the basis of typical cases drawn from medical practice. The laws derived from these observations can, by analogy, also be applied to the radioactive disintegration of isotope families. They also permit formulas to be determined for the activity of multiple-link chain members. The report proceeds by discussing cases, where the baseline substance is the result of nuclear chain reacting. The last issue to be treated within the scope of this study is the radioactive disintegration and simultaneous activation of isotope families. (orig./MG)

  20. Thinking outside the (Voice) Box: A Case Study of Students' Perceptions of the Relevance of Anatomy to Speech Pathology

    Science.gov (United States)

    Weir, Kristy A.

    2008-01-01

    Speech pathology students readily identify the importance of a sound understanding of anatomical structures central to their intended profession. In contrast, they often do not recognize the relevance of a broader understanding of structure and function. This study aimed to explore students' perceptions of the relevance of anatomy to speech…

  1. Saturation of the magnetorotational instability in the unstratified shearing box with zero net flux: convergence in taller boxes

    Science.gov (United States)

    Shi, Ji-Ming; Stone, James M.; Huang, Chelsea X.

    2016-03-01

    Previous studies of the non-linear regime of the magnetorotational instability in one particular type of shearing box model - unstratified with no net magnetic flux - find that without explicit dissipation (viscosity and resistivity) the saturation amplitude decreases with increasing numerical resolution. We show that this result is strongly dependent on the vertical aspect ratio of the computational domain Lz/Lx. When Lz/Lx ≲ 1, we recover previous results. However, when the vertical domain is extended Lz/Lx ≳ 2.5, we find the saturation level of the stress is greatly increased (giving a ratio of stress to pressure α ≳ 0.1), and moreover the results are independent of numerical resolution. Consistent with previous results, we find that saturation of the magnetorotational (MRI) in this regime is controlled by a cyclic dynamo which generates patches of strong toroidal field that switches sign on scales of Lx in the vertical direction. We speculate that when Lz/Lx ≲ 1, the dynamo is inhibited by the small size of the vertical domain, leading to the puzzling dependence of saturation amplitude on resolution. We show that previous toy models developed to explain the MRI dynamo are consistent with our results, and that the cyclic pattern of toroidal fields observed in stratified shearing box simulations (leading to the so-called butterfly diagram) may also be related. In tall boxes the saturation amplitude is insensitive to whether or not explicit dissipation is included in the calculations, at least for large magnetic Reynolds and Prandtl number. Finally, we show MRI turbulence in tall domains has a smaller critical Pmc, and an extended lifetime compared to Lz/Lx ≲ 1 boxes.

  2. Evaluating the Effects of On-Task in a Box as a Class-Wide Intervention

    Science.gov (United States)

    Battaglia, Allison A.; Radley, Keith C.; Ness, Emily J.

    2015-01-01

    The present study evaluated the effects of the On-Task in a Box intervention on student on-task behavior when used as a class-wide intervention. The intervention package includes self-monitoring, video modeling, and reinforcement contingency components. A multiple baseline design across three elementary classrooms was used to determine the effects…

  3. Inside the black box of food safety: a qualitative study of 'non-compliance' among food businesses.

    Science.gov (United States)

    Brough, Mark; Davies, Belinda; Johnstone, Eleesa

    2016-04-01

    Issue addressed This paper examines the meaning of food safety among food businesses deemed non-compliant and considers the need for an insider perspective to inform a more nuanced health promotion practice. Methods In-depth interviews were conducted with 29 food business operators who had recently been deemed 'non-compliant' through Council inspection. Results Paradoxically, these 'non-compliers' revealed a strong belief in the importance of food safety as well as a desire to comply with the regulations as communicated to them by Environmental Health Officers. Conclusions The evidence base of food safety is largely informed by the science of food hazards, yet there is a very important need to consider the practical daily application of food safety practices. This requires a more socially nuanced appreciation of food businesses beyond the simple dichotomy of compliant/ non-compliant. So what? Armed with a deeper understanding of the social context surrounding food safety practice, it is anticipated that a more balanced, collaborative mode of food safety health promotion could develop, which could add to the current model of regulation. PMID:26511403

  4. Modeling and cellular studies

    International Nuclear Information System (INIS)

    Testing the applicability of mathematical models with carefully designed experiments is a powerful tool in the investigations of the effects of ionizing radiation on cells. The modeling and cellular studies complement each other, for modeling provides guidance for designing critical experiments which must provide definitive results, while the experiments themselves provide new input to the model. Based on previous experimental results the model for the accumulation of damage in Chlamydomonas reinhardi has been extended to include various multiple two-event combinations. Split dose survival experiments have shown that models tested to date predict most but not all the observed behavior. Stationary-phase mammalian cells, required for tests of other aspects of the model, have been shown to be at different points in the cell cycle depending on how they were forced to stop proliferating. These cultures also demonstrate different capacities for repair of sublethal radiation damage

  5. Cardboard Boxes: Learning Concepts Galore!

    Science.gov (United States)

    Warner, Laverne; Wilmoth, Linda

    2007-01-01

    Mrs. Keenan, a preschool teacher, observed her 3-year-old granddaughter Riley pull, tug, and stack piles of holiday boxes on the floor. She remembered that her child care director had suggested using boxes as a curriculum theme, but she hadn't given much thought about the idea until now. She said to herself, "I wonder if my children would be as…

  6. Incorporation of Wave Pipelined Techniques into Composite S-Box and AES Architectures

    Directory of Open Access Journals (Sweden)

    M. Senthil Kumar

    2014-10-01

    Full Text Available Advanced Encryption Standard is one of the most successful techniques used in various security applications. The AES technique is known to provide reliable security standards, which is why it is preferred over many other methods. The AES architecture consists of S-Box, Shift-Rows, Mix-Columns and Add Round key. Improving the S-Box structure using pipelining improves the speed of operations along with the security. The main aim of this research study is to design a modified composite S-Box for low area, power and high Speed with high security for application in AES process. In this study, we propose a WPT in S-Box also controlling the registers with a clock-gate structure, to further reduce the operational delay and obtain high security. The modified S-Box is then included in the AES architecture with an additional modification on the overall AES architecture by introducing the WPT in every round of AES operation. This is not only improves the speed of operation and also it provides high security compared to many existing techniques along with the area and power reduction. Simulations have been performed in the ModelSim6.3c and Synthesis is carried out using Xilinx10.1.

  7. Dream Box Learning. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2013

    2013-01-01

    "DreamBox Learning" is a supplemental online mathematics program that provides adaptive instruction for students in grades K-5 and focuses on number and operations, place value, and number sense. The What Works Clearinghouse (WWC) identified one study of "DreamBox Learning" that both falls within the scope of the Elementary…

  8. Designens betydelse vid val av boxvin : En studie om konsumenters preferenser av designfaktorer på bag-in-box-vin.

    OpenAIRE

    Dahlqvist, Sofia; Hedén, Marie

    2015-01-01

    På den svenska marknaden står bag-in-box-vin för över 50 procent av allt vin som säljs och Sverige är det land där bag-in-boxen fått starkast fäste i världen (Fremin, 2012). Det gör att bag-in-box-förpackningen är en stor och betydelsefull produkt för vintillverkare och att ha kunskap om säljande design är viktigt för grafiska formgivare samt övriga involverade företag. Den föreliggande studiens syfte var att undersöka vilka designfaktorer på bagin- box-förpackningar som påverkar konsumentern...

  9. Exotic tree plantations and avian conservation in northern Iberia: a view from a nest–box monitoring study

    Directory of Open Access Journals (Sweden)

    De la Hera, I.

    2013-12-01

    Full Text Available The spread of exotic tree plantations on the North Atlantic coast of the Iberian peninsula raises concern regarding the conservation of avian biodiversity as current trends suggest this region might become a monoculture of Australian Eucalyptus species. To shed more light on the factors promoting differences in avian communities between and within exotic tree (Monterey Pine Pinus radiata and Eucalyptus spp. plantations and native forests in the Urdaibai area (northern Spain, this study aimed to explore (1 how the type of habitat and vegetation characteristics affect bird species richness and the settlement of some particular species during the breeding period, (2 if some reproductive parameters (i.e. egg–laying date and clutch size vary among habitats in a generalist bird species (the Great Tit Parus major, and (3 the existence of differences among habitats in the abundance of a key food resource on which some insectivorous birds are expected to rely upon for breeding (i.e. caterpillars. Our results confirmed that Eucalyptus stands house the poorest bird communities, and identified understory development as an important determinant for the establishment of titmice species. Furthermore, we found that exotic trees showed lower caterpillar abundance than native Oak trees (Quercus robur, which might contribute to explain observed differences among habitats in bird abundance and richness in this region. However, we did not find differences among habitats in egg–laying date and clutch size for the Great Tit, suggesting that the potential costs of breeding in exotic tree plantations would occur in later stages of the reproductive period (e.g. number of nestlings fledged, a circumstance that will require further research.

  10. Students' approaches to mathematical tasks using software as a black-box, glass-box or open-box

    OpenAIRE

    Hosein, Anesa

    2009-01-01

    Three mathematical software modes are investigated in this thesis: black-box software showing no mathematical steps; glass-box software showing the intermediate mathematical steps; and open-box software showing and allowing interaction at the intermediate mathematical steps. The glass-box and open-box software modes are often recommended over the black-box software to help understanding but there is limited research comparing all three. This research investigated students' performance and the...

  11. A Study for University Research Team Management Based on Axiom System for Boxed Pigs%基于智猪博弈公理系统的高校科研团队管理研究

    Institute of Scientific and Technical Information of China (English)

    朱晓阳; 姜殿玉

    2013-01-01

    This article study the“Free Rider”phenomenon commonly exist in University research team based on axiom system for Boxed Pigs.Firstly,The article analyzed the reasons for the“free-rider”phenomenon through the establishment of the axiomatic model,And then by changing the parameters so that the game equilibrium transfer.Finally,put forward some suggestions that can improve the efficience of the University research team according to the model analysis results.In order to provide a scientific and quantitative decision-making Basis for University research team.management.%  基于智猪博弈公理化系统研究了高校科研团队中普遍存在的“搭便车”现象。首先通过建立公理化模型分析了“搭便车”现象产生的原因,继而通过改变参数使得该博弈的均衡解转移,最后依据模型分析结果提出了提高高校科研团队运作效率的方案。为高校科研团队的管理提供科学的、量化的决策依据。

  12. 一类智猪博弈公理系统与知识型员工激励问题研究%One Axiom System for Boxed Pigs and a Study for Knowledge-based Employee Incentive

    Institute of Scientific and Technical Information of China (English)

    王茜; 冯娟

    2014-01-01

    基于一类智猪博弈公理化系统研究企业中普遍存在的“搭便车”现象。首先对企业运作效率不高的原因进行分析,继而建立知识型员工的博弈模型,通过改变参数使得该博弈的均衡解转移,最后依据模型分析结果提出提高企业运作效率的方案。为企业中知识型员工的管理提供科学的、定量化的决策依据。%This paper studied the phenomenon of the“free-rider”prevalent in the enterprise based on the axiom system for Boxed Pigs.Firstly analysis the reason that the enterprise operational efficiency is not high,and then set up the game model of knowledge workers,by changing the parameters so that the game equilibrium transfer.Finally,according to the model analysis results to improve the operational efficiency of enterprises.To provide for the management of knowledge workers in the enterprise scientific and quantitative basis for decision making.

  13. Visualize Black-box of NN Model and its Application in Dimensionality Reduction%神经网络模型的透明化及输入变量约简

    Institute of Scientific and Technical Information of China (English)

    姚立忠; 李太福; 易军; 苏盈盈; 胡文金; 肖大志

    2012-01-01

    Since the neural network can easily fit the nonlinear mapping from the input space to the output space, the users of artificial neural network directly use it to get the black-box model with data pairs including input variables and output variables, of ten without taking dependencies between the input variables and output variables into account So, there are often redundant variables in the model which would result in poor reliability and robustness. An approach to increase visual capability for black-box properties of neural network was proposed. Firstly, the network interpretation diagram is employed to make the network transparency. Then, connection weights method is used to compute the relative contribution of each input variable for estimating the importance to the output variable. Lastly, the significance tests of the connection weights and contribution ratios of input variables are implemented using the improved randomization tests for trimming the model, and the redundant variables can be eliminated by the intersection of the variables which are not significant for the overall contribution and the relative contribution rate to realize dimensionality reduction of neural network model The experimental results indicate that the method can increase the transparency of model, select the best input variable set, eliminate redundant input variables,and improve the reliability and robustness of the model. Therefore, the study provides a new approach to visualize neural network model and eliminates redundant input variables.%由于神经网络很容易实现从输入空间到输出空间的非线性映射,因此,神经网络应用者往往未考虑输入变量和输出变量之间的相关性,直接用神经网络来实现输入变量与输出变量之间的黑箱建模,致使模型中常存在冗余变量,并造成模型可靠性和鲁棒性差.提出一种透明化神经网络黑箱特性的方法,并用它剔除模型中的冗余变量.该方法首先利用神

  14. Method of positioning channel box

    International Nuclear Information System (INIS)

    Upon measuring the dimension of a channel box by disposing ultrasonic sensors to the uppermost portion of a measuring device main body, the deviation of the channel box from the center of the device main body is detected by measuring the distance betwen the sensors at the uppermost portion of the device main body and the lower end of the channel box for four surfaces simultaneously. The direction and the distance for moving the channel box to the center of the device main body are calculated based on the results to feedback tham for the operation of a fuel exchanger, thereby positioning the channel box upon insertion to the device main body. That is, a fuel assembly loaded with the channel box is gradually brought down being suspended from a crane and the position of the channel box is recognized by the ultrasonic sensors, thereafter, the position of the center is corrected and it is brought down again and the outer dimension is measured. Accurate positioning in a short periodof time is enabled and operator's burden can be mitigated to prevent the danger of indury. (N.H.)

  15. Joint design and model tests of extra-long-span continuous box girder bridge composed of UHPC%超大跨径UHPC连续箱梁桥接缝设计及模型试验

    Institute of Scientific and Technical Information of China (English)

    张策; 邵旭东; 张阳

    2015-01-01

    With the precast segment cantilever method,a bracket joint between segments is proposed for the extra-long-span continuous box girder bridge composed of ultra-high performance concrete (UHPC ). The optimization analysis is conducted based on some parameters,such as the horizontal angle of bracket joint,the ratio of joint tooth block depth and height,and the ratio of joint tooth block height to beam height. The optimal ones are less than 45 ,great than 1/10, and 1/3 ~ 2/3 correspondingly. A double cantilever box girder with bracket joint is designed according to the optimization results. Combining with model tests and numerical analysis,the shear behavior of web ’s joint and the influence of diaphragm plates on the joint performance are studied. The results demonstrate that the shear behavior of web’s joint is strong,and the shear capacity of joint can be increased by intensive diaphragm plates in thin-walled box girder. The cracking strain in joint’s corner is up to 455με,and the corresponding stress is about 9. 23MPa. The results are much greater than those of the ordinary concrete joint,and the resistance cracking degree of safety approaches 1. 63.%针对超大跨径UHPC连续箱梁桥,提出悬臂拼装法施工的牛腿式UHPC节段间接缝,并对其倾角、深高比、齿梁高之比进行优化设计,得到接缝牛腿最优水平倾角为0°~45°,深高比≥1/10,齿梁高比为1/3~2/3。利用优化结果设计制作一个双悬臂梁接缝模型,采用模型试验与数值分析相结合的方法,研究薄壁箱梁拼装节段腹板接缝的抗剪性能及横隔板对腹板接缝性能的影响。静力试验的结果与数值模拟分析的结果都表明:薄壁箱梁腹板接缝抗剪性能强,密集横隔板能提高接缝抗剪承载力,接缝角趾开裂应变达到455με,相应计算应力达14.71MPa,远大于普通混凝土的接缝强度,抗裂安全度可达1.63。

  16. Numerical study of fluid resonance induced by wave action on multi-boxes with narrow gaps%波浪与带窄缝多箱体作用共振现象的模拟研究

    Institute of Scientific and Technical Information of China (English)

    宁德志; 苏晓杰; 滕斌

    2015-01-01

    Based on wave generation technique by a inner‐domain source ,a two‐dimensional nonlinear numerical wave flume over time is developed to investigate the fluid resonance induced by the interaction between wave and multi‐objects with narrow gaps .In the numerical model ,the fully nonlinear kinematic and dynamic boundary condi‐tions are set for the instantaneous free surface;the artificial damping is introduced into the gap to simulate the vis‐cous dissipation due to vortex motion and flow separation;the computational domain is discretized using higher‐or‐der boundary elements .The proposed model is validated by the published experimental and numerical data of the relative wave height at two narrow gaps of three boxes .Numerical experiments are performed to study the follow‐ing :the effects of the number of the boxes on the resonant frequency ,wave height at various gaps and the reflected and transmitted wave heights of the objects .%针对波浪与带有窄缝多箱体结构作用产生的流体共振问题,建立了基于域内源造波技术的二维非线性时域数值波浪水槽模型,其中自由水面满足完全非线性运动学和动力学边界条件,窄缝内流体引入人工阻尼来等效由于涡旋运动和流动分离引起的黏性耗散,计算域边界采用高阶边界元进行离散。通过模拟三箱体间两窄缝内相对波高变化,并与已发表的数值与实验结果对比,验证了本模型的准确性。同时通过大量的数值计算,分析了箱体数量对窄缝内水体共振频率、共振波高以及对结构反射波高和透射波高的影响。

  17. Microclimate boxes for panel paintings

    DEFF Research Database (Denmark)

    Wadum, Jørgen

    The use of microclimate boxes to protect vulnerable panel paintings is, therefore, not a new phenomenon of the past two or three decades. Rather, it has been a concern for conservators and curators to protect these objects of art at home and in transit since the end of the nineteenth century. The...... increased number of travelling exhibitions in recent years has heightened the need to protect paintings during circulation (Thomson 1961; Mecklenburg 1991). The use and design of microclimate boxes have been evolving since 1892. These boxes may be divided into three broad groups: those using an active...

  18. Two-dimensional box plot

    OpenAIRE

    Phattrawan Tongkumchum

    2005-01-01

    In this paper we propose a two-dimensional box plot, a simple bivariate extension of the box plot and the scatter plot. This plot comprises a pair of trapeziums oriented in the direction of a fitted straight line, with symbols denoting extreme values. The choice for the fitted straight resistant line showing the relationship between the two variables is Tukey’s resistance line. The main components of the plot are an inner box containing 50% of the projection points of the observations on the ...

  19. Reconciling White-Box and Black-Box Perspectives on Behavioral Self-adaptation

    DEFF Research Database (Denmark)

    Bruni, Roberto; Corradini, Andrea; Gadducci, Fabio; Hölzl, Matthias; Lluch Lafuente, Alberto; Vandin, Andrea; Wirsing, Martin

    This paper proposes to reconcile two perspectives on behavioral adaptation commonly taken at different stages of the engineering of autonomic computing systems. Requirements engineering activities often take a black-box perspective: A system is considered to be adaptive with respect to an...... environment whenever the system is able to satisfy its goals irrespectively of the environment perturbations. Modeling and programming engineering activities often take a white-box perspective: A system is equipped with suitable adaptation mechanisms and its behavior is classified as adaptive depending on...... whether the adaptation mechanisms are enacted or not. The proposed approach reconciles black- and white-box perspectives by proposing several notions of coherence between the adaptivity as observed by the two perspectives: These notions provide useful criteria for the system developer to assess and...

  20. RELIABILITY BASED DESIGN OF A GEAR BOX

    Directory of Open Access Journals (Sweden)

    D.MADHUSEKHAR

    2014-08-01

    Full Text Available Reliability is the probability that a system, component or device will perform without failure for a specified period of time under specified operating conditions. The concept of reliability is of great importance in the design of various machine members. Conventional engineering design uses a deterministic approach. It disregards the fact that the material properties, the dimensions of the components and the externally applied loads are statistical in nature. In conventional design this uncertainties are covered with a factor of safety, which is not always successful. The growing trend towards reducing uncertainty and increasing reliability is to use the probabilistic approach. In the present work a three shaft four speed gear box and six speed gear box are designed using reliability principles. For the specified reliability of the system (Gear box, component reliability (Gear pair is calculated by considering the system as a series system. Design is considered to be safe and adequate if the probability of failure of gear box is less than or equal to a specified quantity in each of the two failure modes. . All the parameters affecting the design are considered as random variables and all the random variables are assumed to follow normal distribution. A computer program in C++ is developed to calculate the face widths in bending and surface failure modes. The larger one out of the two values is considered. By changing the variations in the design parameters, variations in the face widths are studied.

  1. Aspect ratio dependence in magnetorotational instability shearing box simulations

    CERN Document Server

    Bodo, G; Cattaneo, F; Rossi, P; Ferrari, A

    2008-01-01

    Aims: We study the changes in the properties of turbulence driven by the magnetorotational instability in a shearing box, as the computational domain size in the radial direction is varied relative to the height Methods: We perform 3D simulations in the shearing box approximation, with a net magnetic flux, and we consider computational domains with different aspect ratios Results: We find that in boxes of aspect ratio unity the transport of angular momentum is strongly intermittent and dominated by channel solutions in agreement with previous work. In contrast, in boxes with larger aspect ratio, the channel solutions and the associated intermittent behavior disappear. Conclusions: There is strong evidence that, as the aspect ratio becomes larger, the characteristics of the solution become aspect ratio independent. We conclude that shearing box calculations with aspect ratio unity or near unity may introduce spurious effects.

  2. Myiasis in two box turtles.

    Science.gov (United States)

    Gould, W J; Georgi, M E

    1991-10-15

    Two eastern box turtles (Terrapene carolina carolina) were treated for myiasis caused by Sarcophaga cistudinis. The tortoises were examined because of swellings of the proximal cervical regions. Both fully recovered following surgical removal of multiple larvae. PMID:1748614

  3. In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin.

    Science.gov (United States)

    Santoro, Matteo; Maetzler, Walter; Stathakos, Petros; Martin, Heather L; Hobert, Markus A; Rattay, Tim W; Gasser, Thomas; Forrester, John V; Berg, Daniela; Tracey, Kevin J; Riedel, Gernot; Teismann, Peter

    2016-07-01

    High-mobility group box 1 (HMGB1) is a nuclear and cytosolic protein that is released during tissue damage from immune and non-immune cells - including microglia and neurons. HMGB1 can contribute to progression of numerous chronic inflammatory and autoimmune diseases which is mediated in part by interaction with the receptor for advanced glycation endproducts (RAGE). There is increasing evidence from in vitro studies that HMGB1 may link the two main pathophysiological components of Parkinson's disease (PD), i.e. progressive dopaminergic degeneration and chronic neuroinflammation which underlie the mechanistic basis of PD progression. Analysis of tissue and biofluid samples from PD patients, showed increased HMGB1 levels in human postmortem substantia nigra specimens as well as in the cerebrospinal fluid and serum of PD patients. In a mouse model of PD induced by sub-acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), systemic administration of neutralizing antibodies to HMGB1 partly inhibited the dopaminergic cell death, and reduced the increase of RAGE and tumour necrosis factor-alpha. The small natural molecule glycyrrhizin, a component from liquorice root which can directly bind to HMGB1, both suppressed MPTP-induced HMGB1 and RAGE upregulation while reducing MPTP-induced dopaminergic cell death in a dose dependent manner. These results provide first in vivo evidence that HMGB1 serves as a powerful bridge between progressive dopaminergic neurodegeneration and chronic neuroinflammation in a model of PD, suggesting that HMGB1 is a suitable target for neuroprotective trials in PD. PMID:26921471

  4. Bayesian spatio-temporal kriging with misspecified black-box

    OpenAIRE

    Faye, Papa-Abdulaye; faye, Papa Abdoulaye; Druilhet, Pierre; Azzaoui, Nourddine; Yao, Anne-Françoise

    2015-01-01

    We propose a new algorithm for spatio-temporal prediction. At a given time t, we use a Bayesian kriging model for spatial prediction. The temporal evolution from t to t + 1 is given by a deterministic black-box which can be a complex numerical code or a partial differential equation. As often in practice, the black-box is misspecified, in the sense that its parameters are imprecisely known or may be varying randomly over time. At time t, we use the black-box to obtain a rough prediction at ti...

  5. MADS-box gene family in rice: genome-wide identification, organization and expression profiling during reproductive development and stress

    Directory of Open Access Journals (Sweden)

    Tyagi Akhilesh K

    2007-07-01

    Full Text Available Abstract Background MADS-box transcription factors, besides being involved in floral organ specification, have also been implicated in several aspects of plant growth and development. In recent years, there have been reports on genomic localization, protein motif structure, phylogenetic relationships, gene structure and expression of the entire MADS-box family in the model plant system, Arabidopsis. Though there have been some studies in rice as well, an analysis of the complete MADS-box family along with a comprehensive expression profiling was still awaited after the completion of rice genome sequencing. Furthermore, owing to the role of MADS-box family in flower development, an analysis involving structure, expression and functional aspects of MADS-box genes in rice and Arabidopsis was required to understand the role of this gene family in reproductive development. Results A genome-wide molecular characterization and microarray-based expression profiling of the genes encoding MADS-box transcription factor family in rice is presented. Using a thorough annotation exercise, 75 MADS-box genes have been identified in rice and categorized into MIKCc, MIKC*, Mα, Mβ and Mγ groups based on phylogeny. Chromosomal localization of these genes reveals that 16 MADS-box genes, mostly MIKCc-type, are located within the duplicated segments of the rice genome, whereas most of the M-type genes, 20 in all, seem to have resulted from tandem duplications. Nine members belonging to the Mβ group, which was considered absent in monocots, have also been identified. The expression profiles of all the MADS-box genes have been analyzed under 11 temporal stages of panicle and seed development, three abiotic stress conditions, along with three stages of vegetative development. Transcripts for 31 genes accumulate preferentially in the reproductive phase, of which, 12 genes are specifically expressed in seeds, and six genes show expression specific to panicle development

  6. Frequency distribution of TATA Box and extension sequences on human promoters

    OpenAIRE

    2006-01-01

    Background TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear. Results In this study, we conduct a dedicated analysis on the frequency distribution of TATA Box and its extension sequences on human promoters. Sixteen TATA elements derived from the TATA Box motif, TATAWAWN, are classified into three distribution patterns: peak, bottom-peak, and bottom. Fourteen TATA extension sequences are predicted to be the ne...

  7. The gradient flow in a twisted box

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Alberto [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2013-08-15

    We study the perturbative behavior of the gradient flow in a twisted box. We apply this information to define a running coupling using the energy density of the flow field. We study the step-scaling function and the size of cutoff effects in SU(2) pure gauge theory. We conclude that the twisted gradient flow running coupling scheme is a valid strategy for step-scaling purposes due to the relatively mild cutoff effects and high precision.

  8. Thinking Outside the Box

    International Nuclear Information System (INIS)

    The World Nuclear Transport Institute was formed to fill a need to provide a dedicated vehicle for the radioactive transport and packaging industry sectors worldwide, to exchange information and ideas, all with a view to working toward consolidated industry positions on the key issues affecting safe, efficient and reliable transport. WNTI was also intended to be a strong voice for industry in those international and national bodies where deliberations on such transport safety issues take place. The very fact that companies, sometimes in competition with each other, were prepared to come together in this way, reflects two important points: firstly, it represents an acknowledgement on industry's part that safe, effective and reliable transport is the sine qua non, the absolute essential. And second, it is a recognition that it is enhanced to the extent that industry is able to collaborate to this end. This is thinking outside the box. Another important attribute of safety is 'stability'. Everyone likes to know where he or she stands. The radioactive materials packaging and transport industry thrives within a stable regulatory framework for safety. For a stable regulatory regime allows operators to be properly trained; it allows operators to become familiar with safety requirements, and to be at ease with them. Stability is conducive to safety and efficiency. Stability is good for business too - for stability in package and transport requirements allows sufficient time for a fair return on investment in expensive package design, manufacture, licensing and use over time. Stability should not, however, be opposed to creativity. From experience we can develop new thinking to improve efficiency as illustrated in examples of work related to the packaging and transport of Uranium Concentrates for instance.. Another example is work within WNTI on the thermal test requirements for the packaging of uranium hexafluoride. The robustness of packages is based on the risk factors

  9. Enhancing Advanced Encryption Standard S-Box Generation Based on Round Key

    Directory of Open Access Journals (Sweden)

    Julia Juremi

    2015-05-01

    Full Text Available This paper presents a new AES-like design for key- dependent AES using S-box rotation. The algorithm involves key expansion algorithm together with S-box rotation and this property can be used to make the S-box key-dependent, hence providing a better security to the block cipher. Fixed S-box allows attackers to study S- box and find weak points while by using key-dependent S-Box approach, it makes it harder for attacker to do any offline analysis of an attack of one particular set of S- boxes. The cipher structure resembles the original AES, only the S-box is made key-dependent without changing the value. This new design is tested using the NIST Statistical Test and will be further cryptanalyzed with algebraic attack in order to permit its subversion or evasion.

  10. Comparison of black-box, glass-box and open-box software for aiding conceptual understanding

    OpenAIRE

    Hosein, Anesa; Aczel, James; Clow, Doug; Richardson, John T. E.

    2008-01-01

    Three mathematical software types: black-box (no steps shown), glass-box (steps shown) and open-box (interactive steps) were used by 32 students to solve conceptual and procedural tasks on the computer via remote observation. Comparison of the three software types suggests that there is no difference in the scores that students receive for conceptual understanding tasks. Students using the black-box are more likely to explore answers than students using the glass and open-box software.

  11. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients: a pilot study

    OpenAIRE

    Tichelaar, Y. I. G. Vladimir; Geertzen, Jan H. B.; Keizer, Doeke; van Wilgen, C. Paul

    2007-01-01

    Complex regional pain syndrome type I is a disorder of the extremities with disability and pain as the most prominent features. This paper describes the results of cognitive behavioural therapy combined with mirror box therapy in three patients with chronic complex regional pain syndrome type I. Before, during and at follow-up the following measurements were assessed: pain (visual analogue scale, 0-100), range of motion, muscle strength, and the areas of allodynia and of hyperalgesia. Further...

  12. Plate forming and break down pizza box

    Science.gov (United States)

    Pantisano, Frank; Devine, Scott M.

    1992-01-01

    A standard corrugated paper pizza box is provided with slit cuts cut through the top panel of the pizza box in a shape to form four circular serving plates with a beveled raised edge and cross slit cuts through the bottom panel of the pizza box separating the box into four essentially equal portions for easy disposal.

  13. Flooding of the Saar-Lorraine Coal Mines: coupling of the regional model of the lower triassic sandstones aquifer with a 'box' model of the mining reservoir

    International Nuclear Information System (INIS)

    Charbonnages de France (CdF) and Deutsche Steinkohle AG (DSK) has mandated the ANTEA/DMT working group to draw up a trans-border groundwater / mining reservoir coupling model for the Center-East sector. This coupling makes it possible to calculate pumping flows, according to pressure losses between mines, in order to prevent brackish water intrusion from mines to the Lower Triassic Sandstones aquifer. (authors)

  14. 利用回声状态网络建立管式聚合反应的灰箱模型%An approach of grey-box modeling with echo state network for tubular polymerization reaction

    Institute of Scientific and Technical Information of China (English)

    秦松; 曹柳林

    2014-01-01

    提出一种利用回声状态网络(echo state network, ESN)建立复杂分布参数系统模型的灰箱建模方法。此建模方法可以充分利用已知机理模型的结构信息和回声状态网络的逼近能力,可更好地描述和解释出系统各变量之间的因果关系,使模型的“灰箱”化程度更高。首先,根据系统方程和先验知识将初始系统特征团引入ESN储备池中,赋予网络节点实际物理意义,并以此建立结构逼近神经网络模型;然后,通过逐步回归分析方法,结合递归最小二乘算法选择最优系统特征团,并对网络结构进行优化,建立起描述系统特性关系的灰箱模型。本文以实验室规模的管式聚合反应过程作为实验对象,建立以温度分布为输出的数学模型,结果表明所提出的灰箱建模方法行之有效。%An approach of grey-box modeling with Echo State Network (ESN) is developed for modeling dynamic processes with nonlinear characteristics. This method can take full advantage of the already known structural information of the mechanism model at the early stage of modeling and make better use of the approximation ability of neural networks, thus resulting in higher accuracy of grey-box modeling. By combination the prior knowledge and systematic equations into ESN state pool, structure approaching neural network (SAAN) is established based on system feature block, and it is given actual significance. Then the optimal fundamental genes were chosen through recursive least square method with stepwise regression analysis to optimize the structure of SANN, so as to get the grey-box model. Detailed process of modeling was described in modeling of tubular polymerization reaction in laboratory scale. The simulation result proves that the approach is effective.ocesses heat exchanger network synthesis by taking place.

  15. Comparison of box-air-mass-factors and radiances for Multiple-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS geometries calculated from different UV/visible radiative transfer models

    Directory of Open Access Journals (Sweden)

    T. Wagner

    2007-01-01

    Full Text Available The results of a comparison exercise of radiative transfer models (RTM of various international research groups for Multiple AXis Differential Optical Absorption Spectroscopy (MAX-DOAS viewing geometry are presented. Besides the assessment of the agreement between the different models, a second focus of the comparison was the systematic investigation of the sensitivity of the MAX-DOAS technique under various viewing geometries and aerosol conditions. In contrast to previous comparison exercises, box-air-mass-factors (box-AMFs for different atmospheric height layers were modelled, which describe the sensitivity of the measurements as a function of altitude. In addition, radiances were calculated allowing the identification of potential errors, which might be overlooked if only AMFs are compared. Accurate modelling of radiances is also a prerequisite for the correct interpretation of satellite observations, for which the received radiance can strongly vary across the large ground pixels, and might be also important for the retrieval of aerosol properties as a future application of MAX-DOAS. The comparison exercises included different wavelengths and atmospheric scenarios (with and without aerosols. The strong and systematic influence of aerosol scattering indicates that from MAX-DOAS observations also information on atmospheric aerosols can be retrieved. During the various iterations of the exercises, the results from all models showed a substantial convergence, and the final data sets agreed for most cases within about 5%. Larger deviations were found for cases with low atmospheric optical depth, for which the photon path lengths along the line of sight of the instrument can become very large. The differences occurred between models including full spherical geometry and those using only plane parallel approximation indicating that the correct treatment of the Earth's sphericity becomes indispensable. The modelled box-AMFs constitute an

  16. First-aid boxes - Reminder

    CERN Multimedia

    GS Department

    2010-01-01

    With a view to ensuring optimum use of the first-aid boxes on the CERN site, we should like to remind you of various changes introduced in March 2009: The TSO of the buildings concerned is responsible for the first-aid boxes, including checking their contents.   First-aid boxes may be restocked ONLY at the CERN stores (SCEM No. 54.99.80). This is no longer possible at the Infirmary. The associated cost is charged to the Departments.   First-aid boxes should be used only for mild injuries. All other cases should be referred to the Medical Service Infirmary (Bldg. 57 – ground-floor, tel. 73802) between 8.00 a.m. and 5.30 p.m. or to the Fire and Rescue Service (tel. 74444). N.B.: This information does not apply to the red emergency first-aid boxes in the underground areas or to the emergency kits for use in the event of being splashed with hydrofluoric acid.

  17. 多箱渡槽槽身静风三分力系数风洞试验研究%A wind tunnel test study on aerostatic coefficients of large scale multi-box aqueduct bridge deck

    Institute of Scientific and Technical Information of China (English)

    李遇春; 邸庆霜; 张文杰; 张婷婷

    2012-01-01

    A wind tunnel test for the six scaled multi-box aqueduct decks (including 3 two-box and 3 three-box models) was conducted. The cases with full and without water, and with different wind attack an- gles are considered respectively. The drag, lift and pitching moment coefficients of multi-box aqueduct decks were obtained by the test result analyses. The surface pressure distributions and the aerostatic coeffi- cients of the test models were displayed and discussed. The results show that: (1) The wind flow field around multi-box aqueduct deck is similar to that of blunt body; (2) The drag force is the most important wind load among the three static loads; (3) The drag coefficient decreases with the increasing of width/ height ratio of aqueduct decks in the whole tendency.%对6个多箱式渡槽槽身刚性测压模型进行了风洞试验研究,分别模拟了满槽、空槽以及不同风攻角的试验工况。根据试验结果得到了槽身模型的静风三分力(阻力、升力和扭矩)系数,讨论了模型风压分布以及三分力系数的变化规律。试验结果表明:(1)多箱式渡槽槽身绕流更趋近于钝体绕流;(2)槽身风荷载主要表现为风阻力;(3)阻力系数在总体趋势上随着槽截面宽高比的增加而减小。试验结果可为多箱渡槽的抗风研究与设计提供初步的参考。

  18. Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke.

    Directory of Open Access Journals (Sweden)

    Mohammed Dehbi

    Full Text Available The molecular mechanisms that initiate the inflammatory response in heatstroke and their relation with tissue injury and lethality are not fully elucidated. We examined whether endogenous ligands released by damaged/stressed cells such as high-mobility group box 1 (HMGB1 signaling through Toll-like receptor 4 (TLR4 may play a pathogenic role in heatstroke. Mutant TLR4-defective (C3H/HeJ and wild type (C3H/HeOuJ mice were subjected to heat stress in an environmental chamber pre-warmed at 43.5 °C until their core temperature reached 42.7°C, which was taken as the onset of heatstroke. The animals were then allowed to recover passively at ambient temperature. A sham-heated group served as a control. Mutant mice displayed more histological liver damage and higher mortality compared with wild type mice (73% vs. 27%, respectively, P<0.001. Compared to wild type mice, mutant mice exhibited earlier plasma release of markers of systemic inflammation such as HMGB1 (206 ± 105 vs. 63 ± 21 ng/ml; P = 0.0018 and 209 ± 100 vs. 46 ± 32 ng/ml; P<0.0001, IL-6 (144 ± 40 vs. 46 ± 20 pg/ml; P<0.001 and 184 ± 21 vs. 84 ± 54 pg/ml; P = 0.04, and IL-1β (27 ± 4 vs. 1.7 ± 2.3 pg/ml; P<0.0001 at 1 hour. Both strains of mice displayed early release of HMGB1 into the circulation upstream of IL-1β and IL-6 responses which remained elevated up to 24 h. Specific inhibition of HMGB1 activity with DNA-binding A Box (600 µg/mouse protected the mutant mice against the lethal effect of heat stress (60% A Box vs. 18% GST protein, P = 0.04. These findings suggest a protective role for the TLR4 in the host response to severe heat stress. They also suggest that HMGB1 is an early mediator of inflammation, tissue injury and lethality in heatstroke in the presence of defective TLR4 signaling.

  19. Box truss analysis and technology development. Task 1: Mesh analysis and control

    Science.gov (United States)

    Bachtell, E. E.; Bettadapur, S. S.; Coyner, J. V.

    1985-01-01

    An analytical tool was developed to model, analyze and predict RF performance of box truss antennas with reflective mesh surfaces. The analysis system is unique in that it integrates custom written programs for cord tied mesh surfaces, thereby drastically reducing the cost of analysis. The analysis system is capable of determining the RF performance of antennas under any type of manufacturing or operating environment by integrating together the various disciplines of design, finite element analysis, surface best fit analysis and RF analysis. The Integrated Mesh Analysis System consists of six separate programs: The Mesh Tie System Model Generator, The Loadcase Generator, The Model Optimizer, The Model Solver, The Surface Topography Solver and The RF Performance Solver. Additionally, a study using the mesh analysis system was performed to determine the effect of on orbit calibration, i.e., surface adjustment, on a typical box truss antenna.

  20. Monitorization of drug content in furosemide and lorazepam tablets stored in multidose pill boxes

    Directory of Open Access Journals (Sweden)

    Jessica Martins

    2010-01-01

    Full Text Available Background : Therapeutic nonadherence is a major health problem, particularly when therapeutic regimens are complex and long-lasting. Therefore, tools such as multidose pill boxes have been designed to provide the means for higher therapeutic compliance. However, no studies are available reporting on their capacity to keep the drug content of the stored tablets unaltered. Objective : This work aimed at monitoring the drug content of tablets stored in multidose boxes for a period of two weeks. Materials and Methods : Furosemide and lorazepam were selected as model drugs, given their frequent chronic use, which is coherent with the profile of medicines susceptible of storage in the referred boxes. Variations of the tablets drug content were assessed as a function of temperature (25°C and 40°C and the presence of blister. Results and Discussion : The obtained results allowed concluding that concerning temperature, only lorazepam tablets registered drug content alterations and only when stored at 40°C. On the other side, it was concluded that the absence of blister does not compromise the drug content of the studied tablets. Conclusion : In the specific conditions of this study, the storage of these medicines in multidose boxes is considered reliable and adequate.

  1. Effect of material uncertainties on dynamic response of segmental box girder bridge

    Directory of Open Access Journals (Sweden)

    Suchart Limkatanyu

    2007-11-01

    Full Text Available The main objective of this paper was to investigate the effect of material uncertainties on dynamic response of segmental box girder bridge subjected to a moving load, in this case a rapid passing trains. Literatures concerned with the design of segmental box girder bridge, the application of finite element analysis to model the segmental box girder bridge, and the minimum requirement for structural conditions of the bridge were described and discussed in detail. A series of finite element analysis was carried out using SAP2000 Nonlinear software. The effect was investigated by varying the Modulus of Elasticity by 5%, 10% and 15%. The results were then compared with the case of assumed uniform property which had already been checked for model accuracy using the Standard prEN 1991-2. The results showed that, for the uniform case, the dynamic responses of the bridge gave the highest response at the resonance speed. When considering the non-uniform material properties (non-uniform case, the effect of material uncertainties appeared to have an effect on both displacement and acceleration responses. Nonetheless, the dynamic factor provided in the design code was sufficient for designing the segmental box girder bridge with either uniform or non-uniform material properties for the train speeds considered in this study.

  2. BoxLib with Tiling: An AMR Software Framework

    CERN Document Server

    Zhang, Weiqun; Day, Marcus; Nguyen, Tan; Shalf, John; Unat, Didem

    2016-01-01

    In this paper we introduce a block-structured adaptive mesh refinement (AMR) software framework that incorporates tiling, a well-known loop transformation. Because the multiscale, multiphysics codes built in BoxLib are designed to solve complex systems at high resolution, performance on current and next generation architectures is essential. With the expectation of many more cores per node on next generation architectures, the ability to effectively utilize threads within a node is essential, and the current model for parallelization will not be sufficient. We describe a new version of BoxLib in which the tiling constructs are embedded so that BoxLib-based applications can easily realize expected performance gains without extra effort on the part of the application developer. We also discuss a path forward to enable future versions of BoxLib to take advantage of NUMA-aware optimizations using the TiDA portable library.

  3. Numerical Characterization of a Composite Bonded Wing-Box

    Science.gov (United States)

    Smeltzer, Stanley S., III; Lovejoy, Andrew E.; Satyanarayana, Arunkumar

    2008-01-01

    The development of composite wing structures has focused on the use of mechanical fasteners to join heavily-loaded areas, while bonded joints have been used only for select locations. The focus of this paper is the examination of the adhesive layer in a generic bonded wing box that represents a "fastenerless" or unitized structure in order to characterize the general behavior and failure mechanisms. A global/local approach was applied to study the response of the adhesive layer using a global shell model and a local shell/solid model. The wing box was analyzed under load to represent a high-g up-bending condition such that the strains in the composite sandwich face sheets are comparable to an expected design allowable. The global/local analysis indicates that at these wing load levels the strains in the adhesive layer are well within the adhesive's elastic region, such that yielding would not be expected in the adhesive layer. The global/local methodology appears to be a promising approach to evaluate the structural integrity of the adhesively bonded structures.

  4. Spontaneous symmetry breaking in a split potential box

    CERN Document Server

    Shamriz, Elad; Malomed, Boris A

    2016-01-01

    We report results of the analysis of the spontaneous symmetry breaking (SSB) in the basic (actually, simplest) model which is capable to produce the SSB phenomenology in the one-dimensional setting. It is based on the Gross-Pitaevskii - nonlinear Schroedinger equation with the cubic self-attractive term and a double-well-potential built as an infinitely deep potential box split by a narrow (delta-functional) barrier. The barrier's strength, epsilon, is the single free parameter of the scaled form of the model. It may be implemented in atomic Bose-Einstein condensates and nonlinear optics. The SSB bifurcation of the symmetric ground state (GS) is predicted analytically in two limit cases, viz., for deep or weak splitting of the potential box by the barrier. For the generic case, a variational approximation (VA) is elaborated. The analytical findings are presented along with systematic numerical results. Stability of stationary states is studied through the calculation of eigenvalues for small perturbations, an...

  5. Gene Duplication and the Evolution of Plant MADS-box Transcription Factors

    Institute of Scientific and Technical Information of China (English)

    Chiara A. Airoldi; Brendan Davies

    2012-01-01

    Since the first MADS-box transcription factor genes were implicated in the establishment of floral organ identity in a couple of model plants,the size and scope of this gene family has begun to be appreciated in a much wider range of species.Over the course of millions of years the number of MADS-box genes in plants has increased to the point that the Arabidopsis genome contains more than 100.The understanding gained from studying the evolution,regulation and function of multiple MADS-box genes in an increasing set of species,makes this large plant transcription factor gene family an ideal subject to study the processes that lead to an increase in gene number and the selective birth,death and repurposing of its component members.Here we will use examples taken from the MADS-box gene family to review what is known about the factors that influence the loss and retention of genes duplicated in different ways and examine the varied fates of the retained genes and their associated biological outcomes.

  6. Experts’ Misinterpretation of Box Plots – a Dual Processing Approach

    Directory of Open Access Journals (Sweden)

    Stephanie Lem

    2014-11-01

    Full Text Available Recent studies have shown that students often misinterpret the area of the box in box plots as representing the frequency or proportion of observations in that interval, while it actually represents density. This misinterpretation has been shown to be based on the saliency of this area and can be explained by heuristic reasoning as defined by dual process theories. In this study we tested whether expert users of box plots also display this misinterpretation and show signs of the same heuristic reasoning as found in students. Using a reaction time test, we found signs of heuristic reasoning in experts, both with respect to accuracy and reaction times. If even experts have difficulty interpreting box plots, one can question whether these are an appropriate form of representation to use when reporting data and deserve the prominent place they currently have in the statistics curriculum.

  7. Insights into the quality of DnaA boxes and their cooperativity

    DEFF Research Database (Denmark)

    Hansen, Flemming G.; Christensen, Bjarke Bak; Nielsen, Christina Bang;

    2006-01-01

    Plasmids carrying the mioC promoter region with its two DnaA boxes are as efficient in titration of DnaA protein as plasmids carrying a replicationinactivated oriC region with its five DnaA boxes. The two DnaA boxes upstream of the mioC promoter were mutated in various ways to study the cooperati......Plasmids carrying the mioC promoter region with its two DnaA boxes are as efficient in titration of DnaA protein as plasmids carrying a replicationinactivated oriC region with its five DnaA boxes. The two DnaA boxes upstream of the mioC promoter were mutated in various ways to study the...... cooperativity between the DnaA boxes, and to study in vivo the in vitrodefined 9mer DnaA box consensus sequence TTA/TTNCACA). The quality and cooperativity of the DnaA oxes were determined in two complementary ways: as titration of DnaA protein leading to derepression of the dnaA promoter, and as repression of...... the mioC promoter caused by the DnaA protein binding to the DnaA boxes. Titration of DnaA protein correlated with repression of the mioC promoter. The level of titration and repression with the normal promoter-proximal box (TTTTCCACA) depends strongly on the presence and the quality of a DnaA box in...

  8. Dry boxes and inert atmosphere techniques

    International Nuclear Information System (INIS)

    Practitioners need to conduct experiments with molten salts in an inert atmosphere owing to the chemical reactivity of these media. Most fused salt solvent systems show reactivity to water and/or oxygen, which results in significant chemical changes in the properties of these solvents. Although several studies on the nature of an oxygen/oxide electrode in this melt have been reported, the reactions have not been fully understood because of apparent water contamination in many cases. Nitrate melt systems are also hygroscopic; for example, the LiNO3-KNO3 eutectic (1770C) absorbs water to at least 0.2% by weight. The result is that the electrochemistry of heavier, electropositive metal ions has been significantly altered. In addition, trace amounts of water have been shown to significantly affect the oxygen-oxide redox chemistry in NaNO3-KNO3 melts (2500C). The haloaluminates, which include AlCl3-NaCl (1750C), as well as AlCl3-organic salt binaries are particularly sensitive to the presence of both oxygen and moisture. Oxygen is a strong oxidant in the fused hydroxide systems with formation of superoxide ion from either oxide or water. This chapter describes general, inert atmosphere techniques which can be used by the molten salt experimentalist. Because of the limitations of volatility, vacuum manipulations are not considered. Rather, the use of glove boxes, glove bags, and inert bench-top techniques are discussed. The areas covered are: glove box and bag equipment, operation and maintenance of glove boxes and glove bags, and common operations conducted inside glove boxes

  9. Black-Box Policy Search with Probabilistic Programs

    OpenAIRE

    van de Meent, Jan-Willem; Tolpin, David; Paige, Brooks; Wood, Frank

    2015-01-01

    In this work, we explore how probabilistic programs can be used to represent policies in sequential decision problems. In this formulation, a probabilistic program is a black-box stochastic simulator for both the problem domain and the agent. We relate classic policy gradient techniques to recently introduced black-box variational methods which generalize to probabilistic program inference. We present case studies in the Canadian traveler problem, Rock Sample, and a benchmark for optimal diag...

  10. Innovations in Los Alamos alpha box design

    International Nuclear Information System (INIS)

    Destructive examinations of irradiated fuel pins containing plutonium fuel must be performed in shielded hot cells with strict provisions for containing the plutonium. Alpha boxes provide containment for the plutonium, toxic fission products, and other hazardous highly radioactive materials. The alpha box contains windows for viewing and a variety of transfer systems specially designed to allow transfers in and out of the alpha box without spread of the hazardous materials that are contained in the box. Alpha boxes have been in use in the Wing 9 hot cells at Los Alamos National Laboratory for more than 20 years. Features of the newly designed alpha boxes are presented

  11. Innovations in Los Alamos alpha box design

    Energy Technology Data Exchange (ETDEWEB)

    Ledbetter, J.M.; Dowler, K.E.; Cook, J.H.

    1985-01-01

    Destructive examinations of irradiated fuel pins containing plutonium fuel must be performed in shielded hot cells with strict provisions for containing the plutonium. Alpha boxes provide containment for the plutonium, toxic fission products, and other hazardous highly radioactive materials. The alpha box contains windows for viewing and a variety of transfer systems specially designed to allow transfers in and out of the alpha box without spread of the hazardous materials that are contained in the box. Alpha boxes have been in use in the Wing 9 hot cells at Los Alamos National Laboratory for more than 20 years. Features of the newly designed alpha boxes are presented.

  12. Numerical analysis of biological clogging in two-dimensional sand box experiments

    DEFF Research Database (Denmark)

    Kildsgaard, J.; Engesgaard, Peter Knudegaard

    Two-dimensional models for biological clogging and sorptive tracer transport were used to study the progress of clogging in a sand box experiment. The sand box had been inoculated with a strip of bacteria and exposed to a continuous injection of nitrate and acetate. Brilliant Blue was regularly...... injected during the clogging experiment and digital images of the tracer movement had been converted to concentration maps using an image analysis. The calibration of the models to the Brilliant Blue observations shows that Brilliant Blue has a solid biomass dependent sorption that is not compliant with....... However, in the central parts of the clogged area, the observations and simulations clearly show a complex picture of flow diverting the injected nutrients around the clogged area as fingers. The calibration of the model demonstrates that the physical and microbiological processes Žadvection, dispersion...

  13. On the Dirichlet's Box Principle

    Science.gov (United States)

    Poon, Kin-Keung; Shiu, Wai-Chee

    2008-01-01

    In this note, we will focus on several applications on the Dirichlet's box principle in Discrete Mathematics lesson and number theory lesson. In addition, the main result is an innovative game on a triangular board developed by the authors. The game has been used in teaching and learning mathematics in Discrete Mathematics and some high schools in…

  14. A Box Full of Kisses

    Institute of Scientific and Technical Information of China (English)

    崔增印

    2008-01-01

    The story goes that some time ago,a man pun- ished his 3-year-old daughter for wasting a roll of gold wrapping paper.Money was tight and he became infuriated when the child tried to decorate a box to put under the Christmas tree.Nevertheless,the little girl brought the gift to

  15. Vortex-induced vibration of a suspension bridge with central-slotted box section and its control test study%桥面中央开口悬索桥涡激共振与制涡试验研究

    Institute of Scientific and Technical Information of China (English)

    欧阳克俭; 陈政清; 韩艳; 李红利

    2009-01-01

    Vortex-induced vibration (VIV) of a suspension bridge with central-slottod box section and its control was studied by use of wind tunnel test. The conversion relationships between the resonant amplitudes of the model and those of the prototype bridge were considered. And the correction coefficients of modal shapes were also presented. Two methods were proposed to control VIV successfully. The second method was able to control VIV effectively under the condition that the section shape was not altered and it could meet the requirements of engineering practice. The test al- so indicated that damping could suppress the amplitudes of VIV notably.%研究了中央开口断面悬索桥涡振及其控制风洞试验.考虑了模型涡振幅值和和实桥涡振幅值之间换算的修正系数,风洞试验表明中央开口是导致该种断面形式涡激振动发生的主要原因.所设计的两种制涡方案都能达到控制涡振的目的,在不改变断面形式等因素的前提下,设计的制涡方案二能有效控制涡振,符合工程实际要求.同时试验也表明,阻尼能大幅降低涡振幅值.

  16. Behavior of Reinforced Concrete Box Beam Strengthened with CFRP U-Wrap Strips Under Torsion

    Directory of Open Access Journals (Sweden)

    Ma Shengqiang

    2016-01-01

    Full Text Available The present study focuses on the torsional strengthening behavior of reinforced concrete (RC box section beams that are widely used in bridges. Four RC box beams were fabricated, and three of them were wrapped by carbon fiber-reinforced polymer (CFRP U-wrap strips with or without longitudinal strips. The different wrapping configuration, cracking angle, failure pattern, and tensile strain of fibers were investigated and discussed accordingly. The experimental results addressed that U-wrap strips strengthening also can upgrade the ultimate torque of beams moderately. In particular, using U-wrap and longitudinal strips to bond the box beams increased the torsional stiffness slightly. The same equation from different codes for calculating RC specimens can accurately predict the ultimate strength of the control beam, but the calculation of the fib model overestimated the torsional strengthening improvement of the wrapped specimens. However, Ghobarah et al. assumed approximately 3000με of the average ultimate fiber strain in calculating the ultimate strength of the wrapped box beams which shows in relatively appropriate agreement with testing results.

  17. Positiveness and Pauli exception principle in raw Bloch equations for quantum boxes

    OpenAIRE

    Bidégaray-Fesquet, Brigitte

    2010-01-01

    International audience The aim of this paper is to derive a raw Bloch model for the interaction of light with quantum boxes in the framework of a two-electron-species (conduction and valence) description. This requires a good understanding of the one-species case and of the treatment of level degeneracy. In contrast with some existing literature we obtain a Liouville equation which induces the positiveness and the boundedness of solutions, that are necessary for future mathematical studies...

  18. Positiveness and Pauli exception principle in raw Bloch equations for quantum boxes

    Science.gov (United States)

    Bidégaray-Fesquet, Brigitte

    2010-10-01

    The aim of this paper is to derive a raw Bloch model for the interaction of light with quantum boxes in the framework of a two-electron-species (conduction and valence) description. This requires a good understanding of the one-species case and of the treatment of level degeneracy. In contrast with some existing literature, we obtain a Liouville equation which induces the positiveness and the boundedness of solutions, that are necessary for future mathematical studies involving higher order phenomena.

  19. Positiveness and Pauli exception principle in raw Bloch equations for quantum boxes

    International Nuclear Information System (INIS)

    The aim of this paper is to derive a raw Bloch model for the interaction of light with quantum boxes in the framework of a two-electron-species (conduction and valence) description. This requires a good understanding of the one-species case and of the treatment of level degeneracy. In contrast with some existing literature, we obtain a Liouville equation which induces the positiveness and the boundedness of solutions, that are necessary for future mathematical studies involving higher order phenomena.

  20. Cosmetic Foot Surgery: Fashion's Pandora's Box

    Science.gov (United States)

    ... News, Videos & Podcasts » Articles » Text Size Print Bookmark Cosmetic Foot Surgery: Fashion’s Pandora’s Box? Cosmetic Foot Surgery: Fashion’s Pandora’s Box? Foot and Ankle Surgeons Warn ...

  1. Design of a shaking table test box for a subway station structure in soft soil

    Institute of Scientific and Technical Information of China (English)

    YANG Linde; JI Qianqian; ZHENG Yonglai; YANG Chao; ZHANG Dongliang

    2007-01-01

    A reasonable choice of structure of a model box is significant for a shaking table test to be successful in geo- technical engineering. A model box has been designed for the shaking table test of a subway station structure in the soft soil of Shanghai in the paper. The reasonable geometric similarity scale of the subway station structure has been determined by a 3-D dynamic analysis under the action of lateral equiva- lent static loading. The shape, size and structure of the model box are chosen by considering all the involved factors comprehensively. The shape of the box is similar to that of a typical station structure, and the ratio between the plane dimension of the model ground and that of the model struc- ture is big enough to reduce the influence of boundary condi- tion effectively. The structure is strong enough to avoid being demolished by shaking during a test. The contact conditions between the model soil and box are clear to help the data gained from the test well fit that from numerical analysis. The total weight of the model soil and box is less than the bearing capacity of the shaking table apparatus and there is no reso- nance between the model soil and box. The results show that the model box can be used to simulate the dynamic response of a subway station structure very well, so it provides a firm foundation for the success of the shaking table test of a subway station structure.

  2. Transcriptome-wide analysis of the MADS-box gene family in the orchid Erycina pusilla.

    Science.gov (United States)

    Lin, Choun-Sea; Hsu, Chen-Tran; Liao, De-Chih; Chang, Wan-Jung; Chou, Ming-Lun; Huang, Yao-Ting; Chen, Jeremy J W; Ko, Swee-Suak; Chan, Ming-Tsair; Shih, Ming-Che

    2016-01-01

    Orchids exhibit a range of unique flower shapes and are a valuable ornamental crop. MADS-box transcription factors are key regulatory components in flower initiation and development. Changing the flower shape and flowering time can increase the value of the orchid in the ornamental horticulture industry. In this study, 28 MADS-box genes were identified from the transcriptome database of the model orchid Erycina pusilla. The full-length genomic sequences of these MADS-box genes were obtained from BAC clones. Of these, 27 were MIKC-type EpMADS (two truncated forms) and one was a type I EpMADS. Eleven EpMADS genes contained introns longer than 10 kb. Phylogenetic analysis classified the 24 MIKC(c) genes into nine subfamilies. Three specific protein motifs, AG, FUL and SVP, were identified and used to classify three subfamilies. The expression profile of each EpMADS gene correlated with its putative function. The phylogenetic analysis was highly correlated with the protein domain identification and gene expression results. Spatial expression of EpMADS6, EpMADS12 and EpMADS15 was strongly detected in the inflorescence meristem, floral bud and seed via in situ hybridization. The subcellular localization of the 28 EpMADS proteins was also investigated. Although EpMADS27 lacks a complete MADS-box domain, EpMADS27-YFP was localized in the nucleus. This characterization of the orchid MADS-box family genes provides useful information for both orchid breeding and studies of flowering and evolution. PMID:25917508

  3. Studies on DANESS Code Modeling

    International Nuclear Information System (INIS)

    The DANESS code modeling study has been performed. DANESS code is widely used in a dynamic fuel cycle analysis. Korea Atomic Energy Research Institute (KAERI) has used the DANESS code for the Korean national nuclear fuel cycle scenario analysis. In this report, the important models such as Energy-demand scenario model, New Reactor Capacity Decision Model, Reactor and Fuel Cycle Facility History Model, and Fuel Cycle Model are investigated. And, some models in the interface module are refined and inserted for Korean nuclear fuel cycle model. Some application studies have also been performed for GNEP cases and for US fast reactor scenarios with various conversion ratios

  4. Effect of material uncertainties on dynamic response of segmental box girder bridge

    OpenAIRE

    Suchart Limkatanyu; Kittisak Kuntiyawichai

    2007-01-01

    The main objective of this paper was to investigate the effect of material uncertainties on dynamic response of segmental box girder bridge subjected to a moving load, in this case a rapid passing trains. Literatures concerned with the design of segmental box girder bridge, the application of finite element analysis to model the segmental box girder bridge, and the minimum requirement for structural conditions of the bridge were described and discussed in detail. A series of finite element a...

  5. ArduiPod Box: a low-cost and open-source Skinner box using an iPod Touch and an Arduino microcontroller.

    Science.gov (United States)

    Pineño, Oskar

    2014-03-01

    This article introduces the ArduiPod Box, an open-source device built using two main components (i.e., an iPod Touch and an Arduino microcontroller), developed as a low-cost alternative to the standard operant conditioning chamber, or "Skinner box." Because of its affordability, the ArduiPod Box provides an opportunity for educational institutions with small budgets seeking to set up animal laboratories for research and instructional purposes. A pilot experiment is also presented, which shows that the ArduiPod Box, in spite of its extraordinary simplicity, can be effectively used to study animal learning and behavior. PMID:23813238

  6. Box-shaped halophilic bacteria.

    OpenAIRE

    Javor, B; Requadt, C; Stoeckenius, W

    1982-01-01

    Three morphologically similar strains of halophilic, box-shaped procaryotes have been isolated from brines collected in the Sinai, Baja California (Mexico), and southern California (United States). Although the isolates in their morphology resemble Walsby's square bacteria, which are a dominant morphological type in the Red Sea and Baja California brines, they are probably not identical to them. The cells show the general characteristics of extreme halophiles and archaebacteria. They contain ...

  7. Das k-Box-Produkt

    OpenAIRE

    Elser, Stefan

    2011-01-01

    Ziel dieser Doktorarbeit ist es, bekannte und oft verwendete Eigenschaften des Tychonow-Produkts in analoger Form für das k-Box-Produkt zu beweisen, was bisher noch nicht geschehen ist, und die Verbindung zwischen der Infinitären Kombinatorik und der Topologie zu vertiefen. In der Infinitären Kombinatorik, ein Zweig der modernen Mengenlehre, bedient man sich gerne topologischer Begriffe, um einerseits Ergebnisse zu verdeutlichen und um andererseits den sehr abstrakten kombinatorischen Be...

  8. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application of the l......This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...

  9. Study on Structural Forms of External Prestressing Anchorage for a Novel Continuous UHPC Box-girder Bridge%新型UHPC连续箱梁桥的体外预应力锚固构造形式研究

    Institute of Scientific and Technical Information of China (English)

    邵旭东; 张良; 张松涛; 欧阳泽卉

    2016-01-01

    针对新型UHPC连续箱梁桥的结构特点及预应力体系布置,对其腹板处体外预应力下折索进行齿块锚固研究。对独立矩形齿块进行应力分析,揭示板厚对锚固区壁板外侧“局部弯曲效应”的影响。通过拓扑优化分析构建出一个揭示齿块锚固区传力机理的简化平面杆系模型,提出两种齿块锚固区局部加强的方法。在此基础上,对UHPC箱梁桥的腹板体外预应力锚固齿块进行构造设计,对比6种不同锚固方案,分析横隔板、预应力筋齿块内转向和锚固长度对锚固区受力的影响,最终得出较为合理的体外预应力齿块锚固构造形式。%According to the characteristics of a novel continuous UHPC box-girder bridge and the lay-out of its prestressing system,the anchor block for external tendons on the web was studied.Firstly,the effect of the plate thickness on the“local bending effect”in anchorage zone was evaluated through the anal-ysis of stress in the isolated rectangular anchor block.A simplified plane linkage model was proposed through the topology optimization in order to study the force transfer mechanism in anchorage zone.More-over,two kinds of methods were developed to strengthen the anchorage zone based on the simplified mod-el.On the basis of the above research procedure,six different anchoring schemes of the anchor block for the external tendons were designed.After analyzing and comparing the performance of the different ancho-ring schemes,the effects of diaphragms,steering of prestressing tendons,and anchoring length of the an-chor block on the mechanical behavior of the anchorage zone were evaluated.Finally,a type of reasonable anchor block of the external tendons was obtained.

  10. Intellectual Property (IP) Box Regimes : Tax Planning, Effective Tax Burdens, and Tax Policy Options

    OpenAIRE

    Evers, Lisa

    2015-01-01

    This thesis contributes to the current debate on Intellectual Property (IP) Box regimes and IP tax planning. It provides a comprehensive survey of the 12 IP Box regimes in place in Europe by the end of 2014 and presents effective tax rates associated with the IP Box regimes and the use of popular tax planning models. Moreover, it evaluates the IP Box regimes on the basis of the EU State Aid rules and the EU Code of Conduct for business taxation and discusses options to reform the taxation of ...

  11. Opening the Black Box of Intra-Household Decision-Making : Theory and Non-Parametric Empirical Tests of General Collective Consumption Models

    NARCIS (Netherlands)

    Cherchye, L.J.H.; de Rock, B.; Vermeulen, F.M.P.

    2005-01-01

    We non-parametrically test a general collective consumption model with public consumption and externalities inside the household.We further propose a novel approach to model special cases of the general collective model.These special cases include alternative restrictions on the 'sharing rule' that

  12. Comparative study of measured and modelled number concentrations of nanoparticles in an urban street canyon

    DEFF Research Database (Denmark)

    Kumar, Prashant; Garmory, Andrew; Ketzel, Matthias;

    2009-01-01

    This study presents a comparison between measured and modelled particle number concentrations (PNCs) in the 10-300 nm size range at different heights in a canyon. The PNCs were modelled using a simple modelling approach (modified Box model, including vertical variation), an Operational Street...... entire height of the canyon, showing a well-mixed region up to first ≈2 m and then decreasing PNCs with increased height. The CFD profiles do correctly reproduce the increase from road level to a height of ≈2 m; however, they do not predict the measured PNC decrease higher in the canyon. The PNC...

  13. Somatotype Analysis of Elite Boxing Athletes Compared with Nonathletes for Sports Physiotherapy

    OpenAIRE

    Noh, Ji-Woong; Kim, Ju-Hyun; Kim, Mee-Young; Lee, Jeong-Uk; Lee, Lim-Kyu; Park, Byoung-Sun; Yang, Seung-Min; Jeon, Hye-Joo; Lee, Won-Deok; Kwak, Taek-Yong; Jang, Sung-Ho; Lee, Tae-Hyun; Kim, Ju-Young; Kim, Junghwan

    2014-01-01

    [Purpose] The purpose of this study was to show somatotype and physical characteristic differences between elite boxing athletes and non-athletes. [Methods] The somatotypes of 23 elite boxing athletes and 23 nonathletes were measured with the Heath-Carter method. The subjects were divided into four weight divisions as follows: lightweight, light middleweight, middleweight, and heavyweight class. [Results] The endomorphic component values of the boxing athletes were lower than those of the non...

  14. Smocks and Jocks outside the Box: The Paradigmatic Evolution of Sport and Exercise Psychology

    Science.gov (United States)

    Vealey, Robin S.

    2006-01-01

    The objective of this article is to describe the historical development of sport and exercise psychology, with a particular emphasis on the construction and evolution of the "box" through history. The box represents the dominant paradigm that serves as the model for research and application as it evolves through successive historical eras (Kuhn,…

  15. Ionization box type radiation detector

    International Nuclear Information System (INIS)

    An ionization box for monitoring radiation rays, a first amplification circuit of a multi-stage amplification circuit employing a MOS type FET as an initial stage amplification device, a second amplification circuit employing a junction type FET as an initial stage amplification device, a first change-over switch for switching ionization current depending on input signals, a second change-over switch for switching output signals, and a signal level discrimination circuit are constituted integrally. When radiation dose rate is low, the ionization current is inputted to the first amplification circuit and outputted as a radiation ray monitor signal and, when the radiation dose rate is increased to higher than a predetermined value, the ionization current is inputted to the second amplification circuit and outputted as a radiation ray monitor signal. That is, monitoring accuracy is high when the ionization current is low since the MOS type FET of high input impedance is used. If the ionization current is higher than a predetermined value, there is no worry that the detection becomes impossible since the junction type FET having less worry of causing characteristic change due to high radiation dose rate is used. Accordingly, ionization box type monitor at a high monitoring reliability can be obtained. (N.H.)

  16. F-box proteins in flowering plants

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In eukaryotes, the ubiquitin-mediated protein degradation pathway has been shown to control several key biological processes such as cell division, development, metabolism and immune response. F-box proteins, as a part of SCF (Skp1-Cullin (or Cdc53)-F-box) complex, functioned by interacting with substrate proteins, leading to their subsequent degradation by the 26S proteasome. To date, several F-box proteins identified in Arabidopsis and Antirrhinum have been shown to play important roles in auxin signal transduction, floral organ formation, flowering and leaf senescence. Arabidopsis genome sequence analysis revealed that it encodes over 1000 predicted F-box proteins accounting for about 5% of total predicted proteins. These results indicate that the ubiquitin-mediated protein degradation involving the F-box proteins is an important mechanism controlling plant gene expression. Here, we review the known F-box proteins and their functionsin flowering plants.

  17. Host-Guest Interactions in ExBox4+

    CERN Document Server

    Das, Ranjita

    2014-01-01

    The host-guest interaction between benzene or azine with the newly synthesized ExBox4+ complex is studied with the help of DFT. The solvent phase interaction energy is found to decrease with gradual substitution of methine group of guest benzene ring with N atom in the resultant azine@ExBox4+ complex. The nature of bonding interaction is studied with the help of newly developed NCI plot program package along with energy decomposition analysis (EDA) and charge decomposition analysis (CDA). The interaction is mostly pi-type van der Waals interaction.

  18. Hairy Black Holes in a Box

    CERN Document Server

    Basu, Pallab; Subramanian, P N Bala

    2016-01-01

    We do a systematic study of the phases of gravity coupled to an electromagnetic field and charged scalar in flat space, with box boundary conditions. The scalar-less box has previously been investigated by Braden, Brown, Whiting and York (and others) before AdS/CFT and we elaborate and extend their results in a language more familiar from holography. The phase diagram of the system is analogous to that of AdS black holes, but we emphasize the differences and explain their origin. Once the scalar is added, we show that the system admits both boson stars as well as hairy black holes as solutions, providing yet another way to evade flat space no-hair theorems. Furthermore both these solutions can exist as stable phases in regions of the phase diagram. The final picture of the phases that emerges is strikingly similar to that found recently for holographic superconductors in global AdS, arXiv: 1602.07211. Our construction lays bare certain previously unnoticed subtleties associated to the definition quasi-local c...

  19. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... by the EC Environment Research Programme focusing on assessment of the quality of experimental data and models for dense gas dispersion created within the EC funded research programmes. Technical models are used in a number of areas of industrial hazards assessment. It is becoming more and more...... importance of ensuring that model development is of a standard that is commensurate with the importance of model use. The aim of MEG is to improve the culture in which models are developed and used and so ensure that technical models used in all aspects of major hazard evaluation are up to date with...

  20. Metod of black box and their us

    OpenAIRE

    Novotný, Martin

    2013-01-01

    This thesis on a topic "black-box method and its use" deals with the description of the method of solving problematic tasks as a black box and its use in teaching. Using the theory of systems and cybernetics disciplines, especially cybernetic-pedagogy attempts to describe this method so that it is as efficient as possible and to maximize the benefits for students. Besides, the implementation of selected black box that will be suitable and used for teaching subjects electrotechnics, automatiza...

  1. Characterization and functional studies of forkhead box protein 3(-) lymphocyte activation gene 3(+) CD4(+) regulatory T cells induced by mucosal B cells.

    Science.gov (United States)

    Chu, K-H; Chiang, B-L

    2015-05-01

    The induction of mucosal tolerance has been demonstrated to be an effective therapeutic approach for the treatment of allergic diseases. Our previous study demonstrated that Peyer's patch B cells could convert naive T cells into regulatory T cells (so-called Treg -of-B(P) cells); however, it is important to characterize this particular subset of Treg -of-B cells for future applications. This study aimed to investigate the role of lymphocyte activating gene 3 (LAG3) in mediating the regulatory function of Treg -of-B(P) cells induced by mucosal follicular B (FOB) cells. Microarray analysis and real-time polymerase chain reaction (PCR) were used to assess the gene expression pattern of Treg -of-B(P) cells. To evaluate the role of LAG3, the in-vitro suppressive function and the alleviation of airway inflammation in a murine model of asthma was assessed. Our data indicated that FOB cells isolated from Peyer's patches had the ability to generate more suppressive Treg -of-B cells with LAG3 expression, compared with CD23(lo) CD21(lo) B cells. LAG3 is not only a marker for Treg -of-B(P) cells, but also participate in the suppressive ability. Moreover, CCR4 and CCR6 could be detected on the LAG3(+) , not LAG3(-) , Treg -of-B(P) cells and would help cells homing to allergic lung. In the murine model of asthma, the adoptive transfer of LAG3(+) Treg -of-B(P) cells was able to sufficiently suppress T helper type 2 (Th2) cytokine production, eosinophil infiltration and alleviate asthmatic symptoms. LAG3 was expressed in Treg -of-B(P) cells and was also involved in the function of Treg -of-B(P) cells. In the future, this particular subset of Treg -of-B cells might be used to alleviate allergic symptoms. PMID:25581421

  2. Box traps on an atom chip for one-dimensional quantum gases

    CERN Document Server

    van Es, J J P; van Amerongen, A H; Rétif, C; Whitlock, S; van Druten, N J

    2009-01-01

    We present the implementation of tailored trapping potentials for ultracold gases on an atom chip. We realize highly elongated traps with box-like confinement along the long, axial direction combined with conventional harmonic confinement along the two radial directions. The design, fabrication and characterization of the atom chip and the box traps is described. We load ultracold ($\\lesssim1 \\mu$K) clouds of $^{87}$Rb in a box trap, and demonstrate Bose-gas focusing as a means to characterize these atomic clouds in arbitrarily shaped potentials. Our results show that box-like axial potentials on atom chips are very promising for studies of one-dimensional quantum gases.

  3. Fitting boxes to Manhattan scenes using linear integer programming

    KAUST Repository

    Li, Minglei

    2016-02-19

    We propose an approach for automatic generation of building models by assembling a set of boxes using a Manhattan-world assumption. The method first aligns the point cloud with a per-building local coordinate system, and then fits axis-aligned planes to the point cloud through an iterative regularization process. The refined planes partition the space of the data into a series of compact cubic cells (candidate boxes) spanning the entire 3D space of the input data. We then choose to approximate the target building by the assembly of a subset of these candidate boxes using a binary linear programming formulation. The objective function is designed to maximize the point cloud coverage and the compactness of the final model. Finally, all selected boxes are merged into a lightweight polygonal mesh model, which is suitable for interactive visualization of large scale urban scenes. Experimental results and a comparison with state-of-the-art methods demonstrate the effectiveness of the proposed framework.

  4. Repackaging SRS Black Box TRU Waste

    International Nuclear Information System (INIS)

    Historically, large items of TRU Waste, which were too large to be packaged in drums for disposal have been packaged in various sizes of custom made plywood boxes at the Savannah River Site (SRS), for many years. These boxes were subsequently packaged into large steel ''Black Boxes'' for storage at SRS, pending availability of Characterization and Certification capability, to facilitate disposal of larger items of TRU Waste. There are approximately 107 Black Boxes in inventory at SRS, each measuring some 18' x 12' x 7', and weighing up to 45,000 lbs. These Black Boxes have been stored since the early 1980s. The project to repackage this waste into Standard Large Boxes (SLBs), Standard Waste Boxes (SWB) and Ten Drum Overpacks (TDOP), for subsequent characterization and WIPP disposal, commenced in FY04. To date, 10 Black Boxes have been repackaged, resulting in 40 SLB-2's, and 37 B25 overpack boxes, these B25's will be overpacked in SLB-2's prior to shipping to WIPP. This paper will describe experience to date from this project

  5. Interchangeable breech lock for glove boxes

    Energy Technology Data Exchange (ETDEWEB)

    Lemonds, David Preston

    2015-11-24

    A breech lock for a glove box is provided that may be used to transfer one or more items into the glove box. The breech lock can be interchangeably installed in place of a plug, glove, or other device in a port or opening of a glove box. Features are provided to aid the removal of items from the breech lock by a gloved operator. The breech lock can be reused or, if needed, can be replaced with a plug, glove, or other device at the port or opening of the glove box.

  6. Beyond the Black Box: Coupling x-ray tomographic imaging of multi-phase flow processes to numerical models and traditional laboratory measurements

    DEFF Research Database (Denmark)

    Wildenschild, Dorthe; Porter, M.L.; Schaap, M.G.;

    of recent advances in x-ray microtomography techniques that can generate high-resolution image-based data for (1) validation of pore-scale multi-phase flow models such as the lattice-Boltzmann technique and pore network models (with respect to fluid saturations, fluid distribution, and relationships......Quantitative non-invasive imaging has evolved rapidly in the last decade, and is now being used to assess a variety of problems in vadose zone research, including unsaturated flow and transport of water and contaminants, macropore-dominated processes, soil-water-root interactions, more recent work...

  7. Motivating crowding theory - opening the black box of intrinsic motivation

    DEFF Research Database (Denmark)

    Jacobsen, Christian Bøtcher

    2010-01-01

    . Studies have found support for the motivation crowding claim, but have neglected intrinsic motivation. This study opens the black box of intrinsic motivation and finds a meaningful distinction between task motivation and public service motivation. Among 2,772 physiotherapists in the Danish public sector...

  8. Controlling the transmitted information of a multi-photon interacting with a single-Cooper pair box

    International Nuclear Information System (INIS)

    We study a model of a multi-photon interaction of a single Cooper pair box with a cavity field. The exchange of the information using this system is studied. We quantify the fidelity of the transmitted information. The effect of the system parameters (detuning parameter, field photons, state density and mean photon number) in the fidelity of the transmitted information is investigated. We found that the fidelity of the transmitted information can be controlled using the system parameters

  9. Controlling the transmitted information of a multi-photon interacting with a single-Cooper pair box

    Energy Technology Data Exchange (ETDEWEB)

    Kadry, Heba, E-mail: hkadry1@yahoo.com; Abdel-Aty, Abdel-Haleem, E-mail: hkadry1@yahoo.com; Zakaria, Nordin, E-mail: hkadry1@yahoo.com [Computer and Information Science Department, Universiti Teknologi Petronas, Seri Iskandar, 31750 Tronoh, Perak (Malaysia); Cheong, Lee Yen [Fundamental and Applied Science Department, Universiti Teknologi Petronas, Seri Iskandar, 31750 Tronoh, Perak (Malaysia)

    2014-10-24

    We study a model of a multi-photon interaction of a single Cooper pair box with a cavity field. The exchange of the information using this system is studied. We quantify the fidelity of the transmitted information. The effect of the system parameters (detuning parameter, field photons, state density and mean photon number) in the fidelity of the transmitted information is investigated. We found that the fidelity of the transmitted information can be controlled using the system parameters.

  10. Thinking outside the box: fluctuations and finite size effects

    International Nuclear Information System (INIS)

    The isothermal compressibility of an interacting or non-interacting system may be extracted from the fluctuations of the number of particles in a well-chosen control volume. Finite size effects are prevalent and should be accounted for to obtain a meaningful, thermodynamic compressibility. In the traditional computational setup, where a given simulation box is replicated with periodic boundary conditions, we study particle number fluctuations outside the box (i.e. when the control volume exceeds the box itself), which bear relevant thermodynamic information. We also investigate the related problem of extracting the compressibility from the structure factor in the small wave-vector limit (k → 0). The calculation should be restricted to the discrete set of wave-vectors k that are compatible with the periodicity of the system, and we assess the consequences of considering other k values, a widespread error among beginners. (paper)

  11. Thinking outside the box: fluctuations and finite size effects

    Science.gov (United States)

    Villamaina, Dario; Trizac, Emmanuel

    2014-05-01

    The isothermal compressibility of an interacting or non-interacting system may be extracted from the fluctuations of the number of particles in a well-chosen control volume. Finite size effects are prevalent and should be accounted for to obtain a meaningful, thermodynamic compressibility. In the traditional computational setup, where a given simulation box is replicated with periodic boundary conditions, we study particle number fluctuations outside the box (i.e. when the control volume exceeds the box itself), which bear relevant thermodynamic information. We also investigate the related problem of extracting the compressibility from the structure factor in the small wave-vector limit (k → 0). The calculation should be restricted to the discrete set of wave-vectors k that are compatible with the periodicity of the system, and we assess the consequences of considering other k values, a widespread error among beginners.

  12. Qualification of box HEPA filters for nuclear applications

    International Nuclear Information System (INIS)

    We have successfully completed qualification tests on high efficiency particulate air (HEPA) filters that are encapsulated within a box and manufactured by American Air Filters. The qualification tests are required by the American Society of Mechanical Engineers Standard ASME N509 and the U.S. Military Standard MIL-F-51068 for HEPA filters to be used in nuclear applications. The qualification tests specify minimum filter efficiencies following exposure to heated air, overpressure, and rough handling. Prior to this study, no box HEPA filters from any manufacturer had been qualified despite their wide-spread use in Department of Energy (DOE) facilities. Box HEPA filters are not addressed in any of the existing HEPA standards and only briefly discussed in the Nuclear Air Cleaning Handbook

  13. Principal Investigator-in-a-Box

    Science.gov (United States)

    Young, Laurence R.

    1999-01-01

    Human performance in orbit is currently limited by several factors beyond the intrinsic awkwardness of motor control in weightlessness. Cognitive functioning can be affected by such factors as cumulative sleep loss, stress and the psychological effects of long-duration small-group isolation. When an astronaut operates a scientific experiment, the performance decrement associated with such factors can lead to lost or poor quality data and even the total loss of a scientific objective, at great cost to the sponsors and to the dismay of the Principal Investigator. In long-duration flights, as anticipated on the International Space Station and on any planetary exploration, the experimental model is further complicated by long delays between training and experiment, and the large number of experiments each crew member must perform. Although no documented studies have been published on the subject, astronauts report that an unusually large number of simple errors are made in space. Whether a result of the effects of microgravity, accumulated fatigue, stress or other factors, this pattern of increased error supports the need for a computerized decision-making aid for astronauts performing experiments. Artificial intelligence and expert systems might serve as powerful tools for assisting experiments in space. Those conducting space experiments typically need assistance exactly when the planned checklist does not apply. Expert systems, which use bits of human knowledge and human methods to respond appropriately to unusual situations, have a flexibility that is highly desirable in circumstances where an invariably predictable course of action/response does not exist. Frequently the human expert on the ground is unavailable, lacking the latest information, or not consulted by the astronaut conducting the experiment. In response to these issues, we have developed "Principal Investigator-in-a-Box," or [PI], to capture the reasoning process of the real expert, the Principal

  14. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

    OpenAIRE

    Nakamura, Motonobu; Jo, Jun-ichiro; Tabata, Yasuhiko; ISHIKAWA, Osamu

    2008-01-01

    Autoimmune alopecia (alopecia areata) is considered to be triggered by a collapse of immune privilege in hair follicles. Here we confirmed that infiltrating CD4 T lymphocytes around hair follicles of patients with alopecia areata were primarily CCR5-positive with few CCR4-positive cells, suggesting a dominant role of Th1 cells in the alopecic lesion. Given this finding, we sought to elucidate the effect of cytokine therapy in C3H/HeJ mice, a mouse model of alopecia areata, by applying recombi...

  15. Comprehensive modelling study on observed new particle formation at the SORPES station in Nanjing, China

    Science.gov (United States)

    Huang, Xin; Zhou, Luxi; Ding, Aijun; Qi, Ximeng; Nie, Wei; Wang, Minghuai; Chi, Xuguang; Petäjä, Tuukka; Kerminen, Veli-Matti; Roldin, Pontus; Rusanen, Anton; Kulmala, Markku; Boy, Michael

    2016-03-01

    New particle formation (NPF) has been investigated intensively during the last 2 decades because of its influence on aerosol population and the possible contribution to cloud condensation nuclei. However, intensive measurements and modelling activities on this topic in urban metropolitan areas in China with frequent high-pollution episodes are still very limited. This study provides results from a comprehensive modelling study on the occurrence of NPF events in the western part of the Yangtze River Delta (YRD) region, China. The comprehensive modelling system, which combines the WRF-Chem (the Weather Research and Forecasting model coupled with Chemistry) regional chemical transport model and the MALTE-BOX sectional box model (the model to predict new aerosol formation in the lower troposphere), was shown to be capable of simulating atmospheric nucleation and subsequent growth. Here we present a detailed discussion of three typical NPF days, during which the measured air masses were notably influenced by either anthropogenic activities, biogenic emissions, or mixed ocean and continental sources. Overall, simulated NPF events were generally in good agreement with the corresponding measurements, enabling us to get further insights into NPF processes in the YRD region. Based on the simulations, we conclude that biogenic organic compounds, particularly monoterpenes, play an essential role in the initial condensational growth of newly formed clusters through their low-volatility oxidation products. Although some uncertainties remain in this modelling system, this method provides a possibility to better understand particle formation and growth processes.

  16. Multi-output Model with Box-Jenkins Operators of Quadratic Indices for Prediction of Malaria and Cancer Inhibitors Targeting Ubiquitin- Proteasome Pathway (UPP) Proteins.

    Science.gov (United States)

    Casañola-Martin, Gerardo M; Le-Thi-Thu, Huong; Pérez-Giménez, Facundo; Marrero-Ponce, Yovani; Merino-Sanjuán, Matilde; Abad, Concepción; González-Díaz, Humberto

    2016-01-01

    The ubiquitin-proteasome pathway (UPP) is the primary degradation system of short-lived regulatory proteins. Cellular processes such as the cell cycle, signal transduction, gene expression, DNA repair and apoptosis are regulated by this UPP and dysfunctions in this system have important implications in the development of cancer, neurodegenerative, cardiac and other human pathologies. UPP seems also to be very important in the function of eukaryote cells of the human parasites like Plasmodium falciparum, the causal agent of the neglected disease Malaria. Hence, the UPP could be considered as an attractive target for the development of compounds with Anti-Malarial or Anti-cancer properties. Recent online databases like ChEMBL contains a larger quantity of information in terms of pharmacological assay protocols and compounds tested as UPP inhibitors under many different conditions. This large amount of data give new openings for the computer-aided identification of UPP inhibitors, but the intrinsic data diversity is an obstacle for the development of successful classifiers. To solve this problem here we used the Bob-Jenkins moving average operators and the atom-based quadratic molecular indices calculated with the software TOMOCOMD-CARDD (TC) to develop a quantitative model for the prediction of the multiple outputs in this complex dataset. Our multi-target model can predict results for drugs against 22 molecular or cellular targets of different organisms with accuracies above 70% in both training and validation sets. PMID:26427384

  17. Unification of box shapes in molecular simulations

    NARCIS (Netherlands)

    Bekker, H.

    1997-01-01

    In molecular simulations with periodic boundary conditions the computational box may have five different shapes: triclinic; the hexagonal prism; two types of dodecahedrons; and the truncated octahedron. In this article, we show that every molecular simulation, formulated in one of these boxes, can b

  18. Cosmetic Foot Surgery: Fashion's Pandora's Box

    Science.gov (United States)

    ... Fashion’s Pandora’s Box? A A A | Print | Share Cosmetic Foot Surgery: Fashion’s Pandora’s Box? Foot and ankle ... extreme and imprudent as it may sound, the cosmetic surgery craze isn't just for faces anymore- ...

  19. Modern biotechnology Panacea or new Pandora's box?

    NARCIS (Netherlands)

    Tramper, J.; Yang Zhu, Yang

    2011-01-01

    According to Greek mythology Pandora was sent down to earth upon the orders of Zeus. She was given a mysterious box which she was not allowed to open. However, Pandora was very curious and when she arrived on earth she couldn?t help taking a peek inside the box. She saw that it was filled with gifts

  20. Box Plots in the Australian Curriculum

    Science.gov (United States)

    Watson, Jane M.

    2012-01-01

    This article compares the definition of "box plot" as used in the "Australian Curriculum: Mathematics" with other definitions used in the education community; describes the difficulties students experience when dealing with box plots; and discusses the elaboration that is necessary to enable teachers to develop the knowledge necessary to use them…

  1. Subspace model identification of guided wave propagation in metallic plates

    International Nuclear Information System (INIS)

    In this study, a data-driven subspace system identification approach is proposed for modeling guided wave propagation in plate media. In the data-driven approach, the subspace system identification estimates a mathematical model fitted to experimentally measured data, but the black-box model identified captures the dynamics of wave propagation. To demonstrate the versatility of the black-box model, wave motions in various shapes of aluminum plates are investigated in the study. In addition, a waveform predictor and temperature change indicator are proposed as applications of the black-box models, to further promote the modeling approach to guided wave propagation. (paper)

  2. 49 CFR 178.515 - Standards for reconstituted wood boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for reconstituted wood boxes. 178.515... wood boxes. (a) The identification code for a reconstituted wood box is 4F. (b) Construction requirements for reconstituted wood boxes are as follows: (1) The walls of boxes must be made of...

  3. Atmospheric chemistry of a 33-34 hour old volcanic cloud from Hekla Volcano (Iceland): Insights from direct sampling and the application of chemical box modeling

    Science.gov (United States)

    Rose, William I.; Millard, Genevieve A.; Mather, Tamsin A.; Hunton, Donald E.; Anderson, Bruce; Oppenheimer, Clive; Thornton, Brett F.; Gerlach, Terrence M.; Viggiano, Albert A.; Kondo, Yutaka; Miller, Thomas M.; Ballenthin, John O.

    2006-10-01

    On 28 February 2000, a volcanic cloud from Hekla volcano, Iceland, was serendipitously sampled by a DC-8 research aircraft during the SAGE III Ozone Loss and Validation Experiment (SOLVE I). It was encountered at night at 10.4 km above sea level (in the lower stratosphere) and 33-34 hours after emission. The cloud is readily identified by abundant SO2 (≤1 ppmv), HCl (≤70 ppbv), HF (≤60 ppbv), and particles (which may have included fine silicate ash). We compare observed and modeled cloud compositions to understand its chemical evolution. Abundances of sulfur and halogen species indicate some oxidation of sulfur gases but limited scavenging and removal of halides. Chemical modeling suggests that cloud concentrations of water vapor and nitric acid promoted polar stratospheric cloud (PSC) formation at 201-203 K, yielding ice, nitric acid trihydrate (NAT), sulfuric acid tetrahydrate (SAT), and liquid ternary solution H2SO4/H2O/HNO3 (STS) particles. We show that these volcanically induced PSCs, especially the ice and NAT particles, activated volcanogenic halogens in the cloud producing >2 ppbv ClOx. This would have destroyed ozone during an earlier period of daylight, consistent with the very low levels of ozone observed. This combination of volcanogenic PSCs and chlorine destroyed ozone at much faster rates than other PSCs that Arctic winter. Elevated levels of HNO3 and NOy in the cloud can be explained by atmospheric nitrogen fixation in the eruption column due to high temperatures and/or volcanic lightning. However, observed elevated levels of HOx remain unexplained given that the cloud was sampled at night.

  4. A study of mental models

    Directory of Open Access Journals (Sweden)

    A. Tarciso Borges

    1997-09-01

    Full Text Available The concept of mental models is being used in several areas of knowledge in order to study the representations users have about physical systems and events, as well as the content of such representations. However, it cannot be considered a unitary concept. This paper discusses the assumptions envolved in different areas of knowledge and describes a study of the mental model of magnetism held by students and professionals such as electricians physics teachers, and engineers. The identified model stress two aspects: what is the origin of permanent magnets and what is the mechanism of the magnetic interaction.

  5. Influence of Nest Box Color and Release Sites on Osmia lignaria (Hymenoptera: Megachilidae) Reproductive Success in a Commercial Almond Orchard.

    Science.gov (United States)

    Artz, Derek R; Allan, Matthew J; Wardell, Gordon I; Pitts-Singer, Theresa L

    2014-12-01

    Intensively managed, commercial orchards offer resources for managed solitary bees within agricultural landscapes and provide a means to study bee dispersal patterns, spatial movement, nest establishment, and reproduction. In 2012, we studied the impact of 1) the color of nest boxes covaried with four nest box density treatments and 2) the number of bee release sites covaried with two nest box density treatments on the reproductive success of Osmia lignaria Say in a California almond orchard pollinated by a mixture of O. lignaria and Apis mellifera L. Nest box color influenced the number of nests, total cells, and cells with male and female brood. More nests and cells were produced in light blue nest boxes than in orange or yellow nest boxes. The covariate nest box density also had a significant effect on brood production. The number of release sites did not affect O. lignaria nesting and reproduction, but the number of cavities in nest boxes influenced reproduction. Overall, the color of nest boxes and their distribution, but not the number of release sites, can greatly affect O. lignaria nest establishment and reproductive success in a commercial almond orchard. The ability to locate nesting sites in a homogenous, large orchard landscape may also be facilitated by the higher frequency of nest boxes with low numbers of cavities, and by the ability to detect certain nest box colors that best contrast with the blooming trees. PMID:26470068

  6. How Users Search the Library from a Single Search Box

    Science.gov (United States)

    Lown, Cory; Sierra, Tito; Boyer, Josh

    2013-01-01

    Academic libraries are turning increasingly to unified search solutions to simplify search and discovery of library resources. Unfortunately, very little research has been published on library user search behavior in single search box environments. This study examines how users search a large public university library using a prominent, single…

  7. MADS-box gene evolution-structure and transcription patterns

    DEFF Research Database (Denmark)

    Johansen, Bo; Pedersen, Louise B; Skipper, Martin;

    2002-01-01

    This study presents a phylogenetic analysis of 198 MADS-box genes based on 420 parsimony-informative characters. The analysis includes only MIKC genes; therefore several genes from gymnosperms and pteridophytes are excluded. The strict consensus tree identifies all major monophyletic groups known...

  8. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... evaluation group (MEG) is a European initiative on evaluation of technical models used within the major industrial hazard area and is supported by the EC DGXII, Directorate-General for Science, Research and Development. Closely related to MEG is REDIPHEM, which is the acronym of a research project supported...... by the EC Environment Research Programme focusing on assessment of the quality of experimental data and models for dense gas dispersion created within the EC funded research programmes. Technical models are used in a number of areas of industrial hazards assessment. It is becoming more and more...

  9. Word Boxes Help Children with Learning Disabilities Identify and Spell Words.

    Science.gov (United States)

    Joseph, Laurice M.

    1999-01-01

    Describes Marie Clay's word boxes that help children attend to phonological and orthographic features of words, developing phonemic awareness and improving word recognition and spelling. Describes a study showing that the use of word boxes with several elementary school students with learning disabilities was effective for improving and…

  10. Estimation of Radiation Limit from a Huygens' Box under Non-Free-Space Conditions

    DEFF Research Database (Denmark)

    Franek, Ondrej; Sørensen, Morten; Bonev, Ivan Bonev; Ebert, Hans; Pedersen, Gert Frølund

    The recently studied Huygens' box method has difficulties when radiation of an electronic module is to be determined under non-free-space conditions, i.e. with an enclosure. We propose an estimate on radiation limit under such conditions based only on the Huygens' box data from free...

  11. Stepwise bending of DNA by a single TATA box binding protein

    DEFF Research Database (Denmark)

    Tolic-Nørrelykke, Simon F; Rasmussen, Mette B; Pavone, Francesco S; Berg-Sørensen, Kirstine; Oddershede, Lene B.

    2006-01-01

    The TATA-box binding protein (TBP) is required by all three eucaryotic RNA polymerases for the initiation of transcription from most promoters. TBP recognizes, binds to, and bends promoter sequences called "TATA-boxes" in the DNA. We present results from the study of individual Saccharomyces cere...

  12. Norm scores of the box and block test for children ages 3-10 years

    NARCIS (Netherlands)

    Jongbloed-Pereboom, M.; Nijhuis-Van der Sanden, M.W.G.; Steenbergen, B.

    2013-01-01

    This study provides new norm scores for the Box and Block Test for gross manual dexterity in children ages 3-10 yr. Two hundred fifteen Dutch children performed the Box and Block Test separately with each hand. We found an age effect for the scores; older children obtained higher scores than younger

  13. Norm Scores of the Box and Block Test for Children Ages 3-10 Years

    NARCIS (Netherlands)

    Jongbloed-Pereboom, M.; Nijhuis-Van der Sanden, M.W.G.; Steenbergen, B.

    2013-01-01

    This study provides new norm scores for the Box and Block Test for gross manual dexterity in children ages 3-10 yr. Two hundred fifteen Dutch children performed the Box and Block Test separately with each hand. We found an age effect for the scores; older children obtained higher scores than younger

  14. Therapeutic Intervention in a Case of Ataxic Dysarthria Associated with a History of Amateur Boxing

    Science.gov (United States)

    McMicken, Betty L.; Ostergren, Jennifer A.; Vento-Wilson, Margaret

    2011-01-01

    The goals of this study were to (a) describe the presenting features of ataxic dysarthria present in a participant with a long history of amateur boxing, (b) describe a novel application of behavioral principles in the treatment of this participant, and (c) discuss implications in the treatment of ataxic dysarthria secondary to boxing. The…

  15. Exploring the "Black Box" of Programming: Applying Systematic Implementation Evaluation to a Structured Camp Curriculum

    Science.gov (United States)

    Mainieri, Tracy L.; Anderson, Denise M.

    2015-01-01

    Camp scholars have designed structured curricula to engender specific outcomes and to break down the "black box" of programming. Implementation evaluation explores how well a program operates when delivered, further breaking down the black box. The purpose of this study was to explore the implementation of a new structured camp…

  16. Sex Differences in a Human Analogue of the Radial Arm Maze: The ''17-Box Maze Test''

    Science.gov (United States)

    Rahman, Q.; Abrahams, S.; Jussab, F.

    2005-01-01

    This study investigated sex differences in spatial memory using a human analogue of the Radial Arm Maze: a revision on the Nine Box Maze originally developed by Abrahams, Pickering, Polkey, and Morris (1997) called the 17-Box Maze Test herein. The task encourages allocentric spatial processing, dissociates object from spatial memory, and…

  17. THE APPLICATION OF A DIAGNOSTIC MODEL: AN EMPIRICAL STUDY

    OpenAIRE

    ROXANA STEGEREAN; CORINA GAVREA; ANAMARIA MARIN

    2010-01-01

    The vast majority of managers and consultants use in conducting organizational diagnosis specific models to identify the organizational aspects that proved to be essential in the past. The object of this paper is to apply such a model within a Romanian organization. More specifically we extended the well known Six Box Model to include, besides the six variables (purpose, structure, rewards, mechanisms, relation and leadership), other interest variables such as external environment and organiz...

  18. ESF SOUTH PORTAL BOX-CUT/HIGHWALL STABILITY ANALYSIS (SCPB:N/A)

    International Nuclear Information System (INIS)

    The main purpose and objective of this analysis is to design a Box-Cut at the ESF South Portal to accommodate the Tunnel Boring Machine's (TBM) exit at the conclusion of the ESF Main Loop construction. The stability of the Highwall and the sidewalls at the Box-Cut are assessed using analytical methods by numerical modeling techniques. A ground reinforcement system for the South Ramp Box-Cut slopes will be recommended. This report summarizes the results of the analyses and provides the details of the recommended ground reinforcement system for the Box-Cut slopes at the South Portal. The reinforcement design details are then incorporated into design output documents for implementation in the field. Method of excavation for the Box-Cut is also discussed and a recommendation is provided in this analysis

  19. Eosinophils Modulate CD4+ T Cell Responses via High Mobility Group Box-1 in the Pathogenesis of Asthma

    OpenAIRE

    Shim, Eun-Jin; Chun, Eunyoung; Lee, Hyun-Seung; Bang, Bo-Ram; Cho, Sang-Heon; Min, Kyung-Up; Park, Heung-Woo

    2014-01-01

    Eosinophils have been reported to modulate T cell responses. Previously, we reported that high-mobility group box 1 protein (HMGB1) played a key role in the pathogenesis of asthma. This study was conducted to test our hypothesis that eosinophils could modulate T cell responses via HMGB1 in the pathogenesis of asthma characterized by eosinophilic airway inflammation. We performed in vitro experiments using eosinophils, dendritic cells (DCs), and CD4+ T cells obtained from a murine model of ast...

  20. Seismic response of skewed RC box-girder bridges

    Institute of Scientific and Technical Information of China (English)

    Ahmed Abdel-Mohti; Gokhan Pekcan

    2008-01-01

    It is critical to ensure the functionality of highway bridges after earthquakes to provide access to important facilities.Since the 1971 San Fernando earthquake,there has been a better understanding of the seismic performance of bridges.Nonetheless,there are no detailed guidelines addressing the performance of skewed highway bridges.Several parameters affect the response of skewed highway bridges under both service and seismic loads which makes their behavior complex.Therefore,there is a need for more research to study the effect of skew angle and other related factors on the performance of highway bridges.This paper examines the seismic performance of a three-span continuous concrete box girder bridge with skew angles from 0 to 60 degrees,analytically.Finite element (FE) and simplified beam-stick (BS) models of the bridge were developed using SAP2000.Different types of analysis were considered on both models such as:nonlinear static pushover,and linear and nonlinear time history analyses.A comparison was conducted between FE and BS,different skew angles,abutment support conditions,and time history and pushover analysis.It is shown that the BS model has the capability to capture the coupling due to skew and the significant modes for moderate skew angles.Boundary conditions and pushover load profile are determined to have a major effect on pushover analysis.Pushover analysis may be used to predict the maximum deformation and hinge formation adequately.

  1. [The design of heat dissipation of the field low temperature box for storage and transportation].

    Science.gov (United States)

    Wei, Jiancang; Suin, Jianjun; Wu, Jian

    2013-02-01

    Because of the compact structure of the field low temperature box for storage and transportation, which is due to the same small space where the compressor, the condenser, the control circuit, the battery and the power supply device are all placed in, the design for heat dissipation and ventilation is of critical importance for the stability and reliability of the box. Several design schemes of the heat dissipation design of the box were simulated using the FLOEFD hot fluid analysis software in this study. Different distributions of the temperature field in every design scheme were constructed intimately in the present study. It is well concluded that according to the result of the simulation analysis, the optimal heat dissipation design is decent for the field low temperature box for storage and transportation, and the box can operate smoothly for a long time using the results of the design. PMID:23488142

  2. Improvements relating to glove boxes

    International Nuclear Information System (INIS)

    It is stated that radiation problems with glove boxes can only be partly overcome by adding shielding to their working faces, since about 25% of the working face may be taken up with glove ports at which the only shielding provided is that of the glove. A glove port cover is here described, mountable above the port, comprising a number of flaps of lead-loaded flexible material. The flaps can be pushed aside by hand to permit access to a glove fixed in the port, but overlap to close off the port when the hand is withdrawn. The lead loaded flexible material preferably has a natural or synthetic rubber base. Constructional details are given. Only the flaps need to be lead-loaded, and to facilitate manufacture and handling the surfaces of the cover are preferably lead-free. Three flaps can suffice, but five or six are preferred. For mounting purposes a cover may have beading at its periphery for clamped location in a groove round the glove port. (U.K.)

  3. Workplace statistical literacy for teachers: interpreting box plots

    Science.gov (United States)

    Pierce, Robyn; Chick, Helen

    2013-06-01

    As a consequence of the increased use of data in workplace environments, there is a need to understand the demands that are placed on users to make sense of such data. In education, teachers are being increasingly expected to interpret and apply complex data about student and school performance, and, yet it is not clear that they always have the appropriate knowledge and experience to interpret the graphs, tables and other data that they receive. This study examined the statistical literacy demands placed on teachers, with a particular focus on box plot representations. Although box plots summarise the data in a way that makes visual comparisons possible across sets of data, this study showed that teachers do not always have the necessary fluency with the representation to describe correctly how the data are distributed in the representation. In particular, a significant number perceived the size of the regions of the box plot to be depicting frequencies rather than density, and there were misconceptions associated with outlying data that were not displayed on the plot. As well, teachers' perceptions of box plots were found to relate to three themes: attitudes, perceived value and misconceptions.

  4. 体内-体外混合配束节段预制拼装箱梁足尺模型试验研究%Full scale model test of segmental precast concrete box girder with external and internal tendons

    Institute of Scientific and Technical Information of China (English)

    郑开启; 卜红旗; 刘钊; 惠卓; 吕志涛

    2013-01-01

    To investigate the structural behavior of segmental precast prestressed concrete box girder un-der the regular service stage and the construction state,a span of 48 m full scale box girder model of this type was tested for the Fourth Nanjing Yangtze River Bridge approach. The assembling and loading plans were de-termined according to the geometric parameters as well as the actual constraints of the girder. This paper focuses on the static performance,such as stress and displacement changes of the girder during segment loading and transporting. Comparative finite element method analysis was also performed for checking. The model test results show that at the regular service stage,the residual deformation of the girder after unloading is small,which demonstrates that the girder keeps in elastic during loading. The tooth joints of segments work well with each other and have no relative slip;the global performance of the girder is good as monotonous. The vertical distribution of longitudinal strain at joint and between joints basically accords with hypothesis of plane section. Also,the stress increment of prestress tendons is linear to the mid-span moment change. Finally,during the segment trans-port stage,it shows that there is sufficient compressive stress of the lower flange of the girder to meet the security requirements of transporting girder.%  以南京长江第四大桥引桥为背景,开展了一孔48 m跨径体内-体外混合配束节段预制拼装箱梁的足尺模型试验,以研究该类箱梁在正常使用阶段和施工状态下的结构行为。根据试验箱梁的尺寸参数以及实际约束条件确定了拼装与加载方案。本文重点研究正常使用荷载和梁上运梁两种工况下梁体应力状况与位移变化等结构静力性能,并与试验梁实体有限元模型进行对比分析。研究结果表明:在正常使用阶段,加、卸载后拼装梁体残余变形较小,基本处于弹性工作状态,整体

  5. Full scale model test of segmental precast concrete box girder with external and internal tendons%体内-体外混合配束节段预制拼装箱梁足尺模型试验研究

    Institute of Scientific and Technical Information of China (English)

    郑开启; 卜红旗; 刘钊; 惠卓; 吕志涛

    2013-01-01

    To investigate the structural behavior of segmental precast prestressed concrete box girder un-der the regular service stage and the construction state,a span of 48 m full scale box girder model of this type was tested for the Fourth Nanjing Yangtze River Bridge approach. The assembling and loading plans were de-termined according to the geometric parameters as well as the actual constraints of the girder. This paper focuses on the static performance,such as stress and displacement changes of the girder during segment loading and transporting. Comparative finite element method analysis was also performed for checking. The model test results show that at the regular service stage,the residual deformation of the girder after unloading is small,which demonstrates that the girder keeps in elastic during loading. The tooth joints of segments work well with each other and have no relative slip;the global performance of the girder is good as monotonous. The vertical distribution of longitudinal strain at joint and between joints basically accords with hypothesis of plane section. Also,the stress increment of prestress tendons is linear to the mid-span moment change. Finally,during the segment trans-port stage,it shows that there is sufficient compressive stress of the lower flange of the girder to meet the security requirements of transporting girder.%  以南京长江第四大桥引桥为背景,开展了一孔48 m跨径体内-体外混合配束节段预制拼装箱梁的足尺模型试验,以研究该类箱梁在正常使用阶段和施工状态下的结构行为。根据试验箱梁的尺寸参数以及实际约束条件确定了拼装与加载方案。本文重点研究正常使用荷载和梁上运梁两种工况下梁体应力状况与位移变化等结构静力性能,并与试验梁实体有限元模型进行对比分析。研究结果表明:在正常使用阶段,加、卸载后拼装梁体残余变形较小,基本处于弹性工作状态,整体

  6. The (1+1) Elitist Black-Box Complexity of LeadingOnes

    OpenAIRE

    Doerr, Carola; Lengler, Johannes

    2016-01-01

    One important goal of black-box complexity theory is the development of complexity models allowing to derive meaningful lower bounds for whole classes of randomized search heuristics. Complementing classical runtime analysis, black-box models help us understand how algorithmic choices such as the population size, the variation operators, or the selection rules influence the optimization time. One example for such a result is the $\\Omega(n \\log n)$ lower bound for unary unbiased algorithms on ...

  7. A comparison of high-mobility group-box 1 protein, lipopolysaccharide-binding protein and procalcitonin in severe community-acquired infections and bacteraemia: a prospective study

    DEFF Research Database (Denmark)

    Gaïni, Shahin; Koldkjaer, Ole G; Møller, Holger J;

    2008-01-01

    immune response when the host is challenged by bacterial pathogens. Procalcitonin (PCT) has been suggested as a marker of severe bacterial infections and sepsis. The aim of the present study was to investigate levels of HMGB1, LBP and PCT in a well-characterised sepsis cohort. The study plan included...

  8. The role of secondary electron collection in box IEMP coupling

    International Nuclear Information System (INIS)

    Analytical models have been developed to estimate the secondary electron current collected at a biased land during box IEMP. The simple models are intended for the use of systems designers who must estimate the threat to active electronics during box IEMP and who may not have access to the large computer codes which simulate SGEMP. Separate theories apply to the nonself-consistent regime (when the collected charge does not greatly perturb the cavity fields) and the spacecharge-limited regime (when the secondary electrons screen the potential near the land). Analytical calculations for simple test cases compare well with selfconsistent SGEMP computer simulations and with data from past experiments at an MBS facility. Underprediction of the response at biases above +100 V suggests that an undetermined physical mechanism becomes important at high biases

  9. Heating Processes Of The Axle-Boxes Of Rolling-Stock On Railway Track Curves

    Directory of Open Access Journals (Sweden)

    Olegas Lunys

    2013-12-01

    Full Text Available The article deals with the heating process of the axle-boxes ofrolling stock when the train is in motion and discusses the forcesacting on the wheel-set when rolling stock moves along the trackcurves. The paper analyses scientific publications relevant tothe forces acting on the wheel-set of rolling stock and focuseson the axle-box heating process. The article also discusses theresults of theoretical studies on wheel-set forces that affect theheat exchange process of axle-boxes for a railway vehicle. Theresearch has determined a change in heating temperatures ofdifferent axle-boxes of rolling stock and reasons for their variationsand tendencies. The paper has estimated an effect of thetrain running along the track curves on the heating intensity ofthe axle-box. Finally, valid conclusions and recommendationshave been provided.

  10. Urban Studies: A Learning Model.

    Science.gov (United States)

    Cooper, Terry L.; Sundeen, Richard

    1979-01-01

    The urban studies learning model described in this article was found to increase students' self-esteem, imbue a more flexible and open perspective, contribute to the capacity for self-direction, produce increases on the feeling reactivity, spontaneity, and acceptance of aggression scales, and expand interpersonal competence. (Author/WI)

  11. Pelagic Nitrogen Cycling in Jiaozhou Bay, a Model Study I: the Conceptual Model

    Institute of Scientific and Technical Information of China (English)

    REN Ling (任玲); ZHANG Manping (张曼平); Brockmann, Uwe H.; FENG Shizuo (冯士笮)

    2003-01-01

    A zero-dimensional box model (PNCMjzb) with six state variables (ammonium, nitrate, dissolved organic nitrogen, phytoplankton, zooplankton and detritus) was developed to study nitrogen cycling in the Jiaozhou Bay pelagic ecosystem. The dominant processes within these compartments are considered with nitrogen as flow currency. Phytoplankton and zooplankton are treated as separate state variables, assuming that the species composition was dominated by two or three species the dynamic constants of which are similar and that they represent the entire plankton community. The microbial loop has not been integrated explicitly in the model. The turnover of bacteria is included implicitly in processes such as detritus decomposition, DON remineralization, pelagic nitrification and denitrification. The model is driven by two forcing variables, viz. water temperature and light intensity. Historical data from the1980s and 1990s were compiled and used for model calibration. In this paper (part I), the consideration of every main compartment in the model is interpreted in detail. And the applied equations and parameters are presented. The main results from the simulations together with discussion about phytoplankton dynamics and primary production in Jiaozhou Bay are presented in the next paper (part II).

  12. Fermionic Casimir energy in a three-dimensional box

    International Nuclear Information System (INIS)

    In this paper we calculate the Casimir energy for a massless fermionic field confined inside a three-dimensional rectangular box. We use the MIT bag model boundary condition for the confinement. We use the direct mode summation method along with the Abel-Plana summation formula to compute the Casimir energy, without any use of regularization or analytic continuation techniques. We obtain a negative Casimir energy, as opposed to the previously reported result for the interior of a three-dimensional sphere.

  13. Parametric Design and Rapid Prototyping of Installation Box for Vehicle Terminal PCB

    Directory of Open Access Journals (Sweden)

    Wang Xingxing

    2016-01-01

    Full Text Available Installation box for vehicle terminal PCB (Printed Circuit Board was took as research object, which is encountered in the process of project developing. Vehicle terminal PCB in actual development process was set as an example, point cloud data were acquired by three coordinate measuring method; Imageware software was used to reconstruct the vehicle terminal PCB model, basic size parameters of vehicle terminal PCB can be got and then design parameters of installation box for vehicle terminal PCB can be determined. Design of the installation box for vehicle terminal PCB was completed based on Solidworks software, then 3D modeling and 2D drawing of installation box for vehicle terminal PCB was gained. Up Plus 2 rapid prototype machine was used to manufacture installation box for vehicle terminal PCB rapidly based on 3D printing technology, then prototype of installation box for vehicle terminal PCB was obtained. It is of certain engineering significant for single (small amount manufacturing of installation box for general PCB.

  14. METHODOLOGY FOR THE NUMBER OF FILTERS NEEDED IN A WASTE BOX

    Energy Technology Data Exchange (ETDEWEB)

    MARUSICH, R.M.

    2007-05-17

    Waste in large waste boxes can generate volatile organic compounds (VOCs) and hydrogen. These waste boxes may or may not have flow paths out of them (although it is believed that most do). These boxes will be retrieved, sampled, and then coated with polyurea. After coating, filters will be installed in the box to keep the concentration of VOCs and hydrogen acceptably low. The MDSA requires that a vent path must be protected during application of the polyurea coating. If the box has been sampled then it is vented and the vent path must be protected. This report provides a model in which the user inputs the free volume of the waste box, sample concentration (ppm of total VOC or volume fraction hydrogen) along with the number of filters to be placed into the waste box lid. Using this information, the model provides an estimate of concentration vs. time or the number of filters needed to reduce the concentration by a specified fraction. If the equations from this report are placed into spreadsheets which are then used to demonstrate TSR compliance, the spreadsheets must come under the Software QA Plan for such documents. Chapters 2 and 3 present the theory. Chapter 4 presents the method with examples of its use found in Chapter 5. Chapter 6 provides the basis far the use of 1,000 ppm as the concentration below which the method is valid under any condition.

  15. 预应力混凝土组合箱梁扭后抗弯性能分析%Bending behavior study of prestressed composite steel-concrete box beams damaged by torsion

    Institute of Scientific and Technical Information of China (English)

    胡少伟; 胡汉林

    2011-01-01

    In order to investigate the bending behavior of the prestressed composite steel-concrete box beams which have been damaged by torsion, five composite box beams are tested by symmetrical load at mid-span. Considering the history of the torsion loading on the beams, and comparing with the test about the intact beam, by tests and analysis are given some important parameters, such as the ultimate bending capacity of the composite beams, curve of moment-deflection at mid-span and curve of the increases of strain in steel beam, and a formula for calculating the bending capacity of the beams is offered in this study. The test results show that the bending capacity of the beams which have been damaged by torsion is lower than the intact beam; the history of the torsion loading would affect the bending capacity of the beams; and the prestressing force can improve the bending capacity of the beams.%为研究预应力混凝土组合箱梁扭后的抗弯性能,进行了5根预应力组合梁的先扭后弯试验.试验在梁跨中对称荷载作用下进行,考虑试验梁受扭矩作用历史,并与完整组合梁的试验进行对比得到扭后预应力组合梁的极限抗弯承载力、跨中弯矩-挠度曲线及钢梁截面应变增长曲线,并提出了预应力组合梁扭后承载力计算公式.试验结果表明:预应力组合梁扭后承弯能力将会降低;受扭历史影响预应力组合梁的抗弯能力;预应力能够提高扭后预应力组合梁的抗弯能力.

  16. 超宽箱梁抗裂混凝土配合比试验研究%Experimental Study of Mix Proportioning of Cracking Resistance Concrete for Very Wide Box Girder

    Institute of Scientific and Technical Information of China (English)

    王运金; 李北星; 唐凯; 胡峰强; 张剑峰

    2012-01-01

    为防止九江长江公路大桥主桥超宽箱梁混凝土的早期开裂,进行专门的抗裂混凝土配合比优化设计试验.通过水化热、绝热温升、平板法塑性收缩开裂、温度~应力试验机开裂等试验方法,研究了胶凝材料组成对混凝土早期抗裂性的影响,配制出抗裂性能良好的C55混凝土.该混凝土采用42.5级p·Ⅱ水泥掺入25%的Ⅰ级粉煤灰、缓凝型聚羧酸盐高性能减水剂配制,绝热温升55.8℃,塑性收缩抗裂等级Ⅱ级,开裂温度8.7℃,应力储备37.3%,实际应用效果良好.%To prevent the concrete for the very wide box girder of the main bridge of Jiujiang Changjiang River Highway Bridge from early stage cracking, the optimal design and experiment for the mix proportioning of cracking resistance concrete for the box girder was specially carried out. By way of the hydration heat testing, adiabatic temperature rise testing, flat slab testing of plastic shrinkage cracking and cracking testing of temperatures-stress testing machine, the influence of the cementitious material compositions on the early stage cracking resistance of the concrete was studied and the C55 concrete having good cracking resistance was accordingly prepared. The concrete is used with the Grade 42. 5 P?II cement added with 25% of the Grade I flyash and high-range water reducer of retarding-type polycarboxylate. The adiabatic temperature rise of the concrete is 55. 8 ?, the level of the plastic shrinkage cracking resistance is grade II, the cracking temperature is 8. 7 ? and the stress reserve is 37. 3%. The practical application of the concrete proves that the effect of the concrete is sound.

  17. Count rate studies of a box-shaped PET breast imaging system comprised of position sensitive avalanche photodiodes utilizing monte carlo simulation.

    Science.gov (United States)

    Foudray, Angela M K; Habte, Frezghi; Chinn, Garry; Zhang, Jin; Levin, Craig S

    2006-01-01

    We are investigating a high-sensitivity, high-resolution positron emission tomography (PET) system for clinical use in the detection, diagnosis and staging of breast cancer. Using conventional figures of merit, design parameters were evaluated for count rate performance, module dead time, and construction complexity. The detector system modeled comprises extremely thin position-sensitive avalanche photodiodes coupled to lutetium oxy-orthosilicate scintillation crystals. Previous investigations of detector geometries with Monte Carlo indicated that one of the largest impacts on sensitivity is local scintillation crystal density when considering systems having the same average scintillation crystal densities (same crystal packing fraction and system solid-angle coverage). Our results show the system has very good scatter and randoms rejection at clinical activity ranges ( approximately 200 muCi). PMID:17645997

  18. Advanced Technology Lifecycle Analysis System (ATLAS) Technology Tool Box (TTB)

    Science.gov (United States)

    Doyle, Monica; ONeil, Daniel A.; Christensen, Carissa B.

    2005-01-01

    The Advanced Technology Lifecycle Analysis System (ATLAS) is a decision support tool designed to aid program managers and strategic planners in determining how to invest technology research and development dollars. It is an Excel-based modeling package that allows a user to build complex space architectures and evaluate the impact of various technology choices. ATLAS contains system models, cost and operations models, a campaign timeline and a centralized technology database. Technology data for all system models is drawn from a common database, the ATLAS Technology Tool Box (TTB). The TTB provides a comprehensive, architecture-independent technology database that is keyed to current and future timeframes.

  19. Packing a cake into a box

    KAUST Repository

    Skopenkov, Mikhail

    2011-05-01

    Given a triangular cake and a box in the shape of its mirror image, how can the cake be cut into a minimal number of pieces so that it can be put into the box? The cake has icing, so we are not allowed to put it into the box upside down. V. G. Boltyansky asked this question in 1977 and showed that three pieces always suffice. In this paper we provide examples of cakes that cannot be cut into two pieces to be put into the box. This shows that three is the answer to Boltyansky\\'s question. We also give examples of cakes which can be cut into two pieces. © THE MATHEMATICAL ASSOCIATION OF AMERICA.

  20. Spacer for supporting fuel element boxes

    International Nuclear Information System (INIS)

    A spacer plate unit arranged externally on each side and at a predetermined level of a polygonal fuel element box for mutually supporting, with respect to one another, a plurality of the fuel element boxes forming a fuel element bundle, is formed of a first and a second spacer plate part each having the same length and the same width and being constituted of unlike first and second materials, respectively. The first and second spacer plate parts of the several spacer plate units situated at the predetermined level are arranged in an alternating continuous series when viewed in the peripheral direction of the fuel element box, so that any two spacer plate units belonging to face-to-face oriented sides of two adjoining fuel element boxes in the fuel element bundle define interfaces of unlike materials

  1. Mystery Boxes, X Rays, and Radiology.

    Science.gov (United States)

    Thomson, Norman

    2000-01-01

    Indicates the difficulties of teaching concepts beyond light and color and creating memorable learning experiences. Recommends sequential activities using the mystery box approach to explain how scientists and doctors use photon applications. (YDS)

  2. Packing a cake into a box

    CERN Document Server

    Skopenkov, Mikhail

    2010-01-01

    Given a cake in form of a triangle and a box that fits the mirror image of the cake, how to cut the cake into a minimal number of pieces so that it can be put into the box? The cake has an icing, so that we are not allowed to put it into the box upside down. V.G. Boltyansky asked this question in 1977 and showed that three pieces always suffice. In this paper we provide examples of cakes that cannot be cut into two pieces to put into the box. This shows that three is the answer to V.G. Boltyansky's question. Also we give examples of cakes which can be cut into two pieces.

  3. Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB

    Energy Technology Data Exchange (ETDEWEB)

    Burles, Kristin, E-mail: burles@ualberta.ca; Buuren, Nicholas van; Barry, Michele

    2014-11-15

    A notable feature of poxviruses is their ability to inhibit the antiviral response, including the nuclear factor kappa B (NFκB) pathway. NFκB is a transcription factor that is sequestered in the cytoplasm until cell stimulation, and relies on the SCF (Skp1, culllin-1, F-box) ubiquitin ligase to target its inhibitor, IκBα, for degradation. IκBα is recruited to the SCF by the F-box domain-containing protein βTrCP. Here, we show that ectromelia virus, the causative agent of mousepox, encodes four F-box-containing proteins, EVM002, EVM005, EVM154, and EVM165, all of which contain Ankyrin (Ank) domains. The Ank/F-box proteins inhibit NFκB nuclear translocation, and this inhibition is dependent on the F-box domain. We also demonstrate that EVM002, EVM005, EVM154, and EVM165 prevent IκBα degradation, suggesting that they target the SCF. This study identifies a new mechanism by which ectromelia virus inhibits NFκB. - Highlights: • Ectromelia virus encodes four Ank/F-box proteins, EVM002, EVM005, EVM154 and EVM165. • The Ank/F-box proteins inhibit NFκB nuclear translocation, dependent on the F-box. • The Ank/F-box proteins prevent IκBα degradation, suggesting they target the SCF. • Deletion of a single Ank/F-box gene from ECTV does not prevent viral NFκB inhibition. • This study identifies a new mechanism by which ectromelia virus inhibits NFκB.

  4. Ectromelia virus encodes a family of Ankyrin/F-box proteins that regulate NFκB

    International Nuclear Information System (INIS)

    A notable feature of poxviruses is their ability to inhibit the antiviral response, including the nuclear factor kappa B (NFκB) pathway. NFκB is a transcription factor that is sequestered in the cytoplasm until cell stimulation, and relies on the SCF (Skp1, culllin-1, F-box) ubiquitin ligase to target its inhibitor, IκBα, for degradation. IκBα is recruited to the SCF by the F-box domain-containing protein βTrCP. Here, we show that ectromelia virus, the causative agent of mousepox, encodes four F-box-containing proteins, EVM002, EVM005, EVM154, and EVM165, all of which contain Ankyrin (Ank) domains. The Ank/F-box proteins inhibit NFκB nuclear translocation, and this inhibition is dependent on the F-box domain. We also demonstrate that EVM002, EVM005, EVM154, and EVM165 prevent IκBα degradation, suggesting that they target the SCF. This study identifies a new mechanism by which ectromelia virus inhibits NFκB. - Highlights: • Ectromelia virus encodes four Ank/F-box proteins, EVM002, EVM005, EVM154 and EVM165. • The Ank/F-box proteins inhibit NFκB nuclear translocation, dependent on the F-box. • The Ank/F-box proteins prevent IκBα degradation, suggesting they target the SCF. • Deletion of a single Ank/F-box gene from ECTV does not prevent viral NFκB inhibition. • This study identifies a new mechanism by which ectromelia virus inhibits NFκB

  5. Simulación y Modelado en el Diseño Mecánico de un Reductor de Velocidad Simulation and Modeling in Mechanical Design of a Speed Reduction Gear Box

    Directory of Open Access Journals (Sweden)

    W. Switek

    2004-01-01

    Full Text Available Se describe un proceso integral asistido por computadora del diseño de un reductor de velocidad que incluye el modelado, simulación y dibujo automático. Se aplicó el programa de simulación Powersim para desarrollar un modelo computarizado de la estructura mecánica. Se han desarrollado programas especiales para producir dibujos bidimensionales del ensamble del reductor de velocidad, por medio del lenguaje AutoLISP existente en AutoCAD. Con el fin de obtener el mejor diseño de las partes, los resultados de los cálculos de Powersim pueden ser transferidos al software Solid Works para el diseño automático tridimensional de partes seleccionadas, utilizando el método de modelado sólido. Con la aplicación del software de elementos finitos es posible crear una malla automática y el desarrollo de un análisis de esfuerzo y deformación de la parte, incluyendo los efectos de la concentración de esfuerzos. Se concluye que el método desarrollado logra diseños rápidos, confiables, con aplicación en la industria y en enseñanzaThis paper describes an integrated computer-aided approach to the design of a gear reduction box involving modeling, simulation and automatic drawing. Powersim simulation software has been applied to develop a computer model of the mechanical structure. Special programs have been developed in order to produce two-dimensional drawings of the speed reducing assembly using AutoLisp language existing in AutoCAD . To obtain the optimal design of the parts, the results of the Powersim calculations can be transferred to Solid Work software for an automatic, three-dimensional design of the selected parts using a solid modeling method. Application of FEM software allows to create an automatic mesh and perform the analysis of the stress and deformation of the part including the effects of the stress concentration. It is concluded that the method developed achieves rapid, reliable designs, useful in both industry and teaching

  6. Decommissioning a tritium glove-box facility

    Energy Technology Data Exchange (ETDEWEB)

    Folkers, C.L.; Homann, S.G.; Nicolosi, A.S.; Hanel, S.L.; King, W.C.

    1979-08-08

    A large glove-box facility for handling reactive metal tritides was decommissioned. Major sections of the glove box were decontaminated and disassembled for reuse at another tritium facility. To achieve the desired results, decontamnation required repeated washing, first with organic liquids, then with water and detergents. Worker protection was provided by simple ventilation combined with careful monitoring of the work areas and employees. Several innovative techniques are described.

  7. Decommissioning a tritium glove-box facility

    International Nuclear Information System (INIS)

    A large glove-box facility for handling reactive metal tritides was decommissioned. Major sections of the glove box were decontaminated and disassembled for reuse at another tritium facility. To achieve the desired results, decontamnation required repeated washing, first with organic liquids, then with water and detergents. Worker protection was provided by simple ventilation combined with careful monitoring of the work areas and employees. Several innovative techniques are described

  8. Random Young diagrams in a Rectangular Box

    DEFF Research Database (Denmark)

    Beltoft, Dan; Boutillier, Cédric; Enriquez, Nathanaël

    We exhibit the limit shape of random Young diagrams having a distribution proportional to the exponential of their area, and confined in a rectangular box. The Ornstein-Uhlenbeck bridge arises from the fluctuations around the limit shape.......We exhibit the limit shape of random Young diagrams having a distribution proportional to the exponential of their area, and confined in a rectangular box. The Ornstein-Uhlenbeck bridge arises from the fluctuations around the limit shape....

  9. Kuala Kemaman hydraulic model study

    International Nuclear Information System (INIS)

    There The problems facing the area of Kuala Kemaman are siltation and erosion at shoreline. The objectives of study are to assess the best alignment of the groyne alignment, to ascertain the most stable shoreline regime and to investigate structural measures to overcome the erosion. The scope of study are data collection, wave analysis, hydrodynamic simulation and sediment transport simulation. Numerical models MIKE 21 are used - MIKE 21 NSW, for wind-wave model, which describes the growth, decay and transformation of wind-generated waves and swell in nearshore areas. The study takes into account effects of refraction and shoaling due to varying depth, energy dissipation due to bottom friction and wave breaking, MIKE 21 HD - modelling system for 2D free-surface flow which to stimulate the hydraulics phenomena in estuaries, coastal areas and seas. Predicted tidal elevation and waves (radiation stresses) are considered into study while wind is not considered. MIKE 21 ST - the system that calculates the rates of non-cohesive (sand) sediment transport for both pure content and combined waves and current situation

  10. Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.

    Science.gov (United States)

    Shinkai, Kentaro; Nakano, Kenji; Cui, Lin; Mizuuchi, Yusuke; Onishi, Hideya; Oda, Yoshinao; Obika, Satoshi; Tanaka, Masao; Katano, Mitsuo

    2016-07-15

    The objective of this study was to examine the implication of Y-box-binding protein-1 (YB-1) for the aggressive phenotypes, prognosis and therapeutic target in pancreatic ductal adenocarcinoma (PDAC). YB-1 expression in PDAC, pancreatic intraepithelial neoplasia (PanIN) and normal pancreas specimens was evaluated by immunohistochemistry, and its correlation with clinicopathological features was assessed in patients with PDAC. The effects of YB-1 on proliferation, invasion and expressions of cell cycle-related proteins and matrix metalloproteinases (MMPs) were analyzed by WST-8, cell cycle and Matrigel invasion assays, Western blotting and quantitative RT-PCR in PDAC cells transfected with YB-1-siRNAs. To verify the significance of YB-1 for tumor progression in vivo, the growth and metastasis were monitored after intrasplenic implantation of ex vivo YB-1 siRNA-transfected PDAC cells, and YB-1-targeting antisense oligonucleotides were intravenously administered in nude mice harboring subcutaneous tumor. The intensity of YB-1 expression and positivity of nuclear YB-1 expression were higher in PDAC than PanIN and normal pancreatic tissues. Nuclear YB-1 expression was significantly associated with dedifferentiation, lymphatic/venous invasion and unfavorable prognosis. YB-1 knockdown inhibited cell proliferation via cell cycle arrest by S-phase kinase-associated protein 2 downregulation and consequent p27 accumulation, and decreased the invasion due to downregulated membranous-type 2 MMP expression in PDAC cells. Tumor growth and liver metastasis formation were significantly suppressed in nude mice after implantation of YB-1-silenced PDAC cells, and the YB-1 targeting antisense oligonucleotide significantly inhibited the growth of subcutaneous tumors. In conclusion, YB-1 may be involved in aggressive natures of PDAC and a promising therapeutic target. PMID:26939718

  11. Nearest-neighbor non-additivity versus long-range non-additivity in TATA-box structure and its implications for TBP-binding mechanism

    OpenAIRE

    Faiger, Hana; Ivanchenko, Marina; Haran, Tali E.

    2007-01-01

    TBP recognizes its target sites, TATA boxes, by recognizing their sequence-dependent structure and flexibility. Studying this mode of TATA-box recognition, termed ‘indirect readout’, is important for elucidating the binding mechanism in this system, as well as for developing methods to locate new binding sites in genomic DNA. We determined the binding stability and TBP-induced TATA-box bending for consensus-like TATA boxes. In addition, we calculated the individual information score of all st...

  12. Health Related Behaviours in Normal Weight and Overweight Preschoolers of a Large Pan-European Sample: The ToyBox-Study.

    Science.gov (United States)

    Cardon, Greet; De Bourdeaudhuij, Ilse; Iotova, Violeta; Latomme, Julie; Socha, Piotr; Koletzko, Berthold; Moreno, Luis; Manios, Yannis; Androutsos, Odysseas; De Craemer, Marieke

    2016-01-01

    The aim of this study was to investigate the associations of health related behaviours (HRB) with Body Mass Index (BMI) in preschoolers, and to study the likelihood of being overweight/obese in relation to compliance with recommended HRB. The sample consisted of 3301 normal weight and overweight/obese preschoolers (mean age: 4.7 years; 52% boys, 85% normal weight) from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain). Height and weight were measured, total daily step counts were registered during six days, and HRB were assessed with validated parental surveys in 2012. Multiple linear and logistic regression analyses were performed. Only few HRB were significantly associated with BMI. In boys, higher water intake and higher soft drink and higher fruit consumption were significantly associated with higher BMI. Boys drinking less water than recommended were less likely to be overweight/obese (OR = 0.60), while boys who consume soft drinks were more likely to be overweight/obese (OR = 1.52). In girls, higher water intake, higher vegetable consumption, and more TV time on weekend days were significantly associated with higher BMI. Girls eating less vegetables than recommended were less likely to be overweight/obese (OR = 0.62), and girls who engaged in quiet play for more than 90 minutes on weekend days were more likely to be overweight/obese (OR = 1.64). In general, the associations between HRB and BMI or being overweight/obese were limited and mainly related to dietary intake. Awareness campaigns for caregivers should stress that HRB of young children are important and independent of children's weight status. PMID:26950063

  13. Health Related Behaviours in Normal Weight and Overweight Preschoolers of a Large Pan-European Sample: The ToyBox-Study.

    Directory of Open Access Journals (Sweden)

    Greet Cardon

    Full Text Available The aim of this study was to investigate the associations of health related behaviours (HRB with Body Mass Index (BMI in preschoolers, and to study the likelihood of being overweight/obese in relation to compliance with recommended HRB. The sample consisted of 3301 normal weight and overweight/obese preschoolers (mean age: 4.7 years; 52% boys, 85% normal weight from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain. Height and weight were measured, total daily step counts were registered during six days, and HRB were assessed with validated parental surveys in 2012. Multiple linear and logistic regression analyses were performed. Only few HRB were significantly associated with BMI. In boys, higher water intake and higher soft drink and higher fruit consumption were significantly associated with higher BMI. Boys drinking less water than recommended were less likely to be overweight/obese (OR = 0.60, while boys who consume soft drinks were more likely to be overweight/obese (OR = 1.52. In girls, higher water intake, higher vegetable consumption, and more TV time on weekend days were significantly associated with higher BMI. Girls eating less vegetables than recommended were less likely to be overweight/obese (OR = 0.62, and girls who engaged in quiet play for more than 90 minutes on weekend days were more likely to be overweight/obese (OR = 1.64. In general, the associations between HRB and BMI or being overweight/obese were limited and mainly related to dietary intake. Awareness campaigns for caregivers should stress that HRB of young children are important and independent of children's weight status.

  14. Health Related Behaviours in Normal Weight and Overweight Preschoolers of a Large Pan-European Sample: The ToyBox-Study

    Science.gov (United States)

    Cardon, Greet; De Bourdeaudhuij, Ilse; Iotova, Violeta; Latomme, Julie; Socha, Piotr; Koletzko, Berthold; Moreno, Luis; Manios, Yannis; Androutsos, Odysseas; De Craemer, Marieke

    2016-01-01

    The aim of this study was to investigate the associations of health related behaviours (HRB) with Body Mass Index (BMI) in preschoolers, and to study the likelihood of being overweight/obese in relation to compliance with recommended HRB. The sample consisted of 3301 normal weight and overweight/obese preschoolers (mean age: 4.7 years; 52% boys, 85% normal weight) from six European countries (Belgium, Bulgaria, Germany, Greece, Poland, Spain). Height and weight were measured, total daily step counts were registered during six days, and HRB were assessed with validated parental surveys in 2012. Multiple linear and logistic regression analyses were performed. Only few HRB were significantly associated with BMI. In boys, higher water intake and higher soft drink and higher fruit consumption were significantly associated with higher BMI. Boys drinking less water than recommended were less likely to be overweight/obese (OR = 0.60), while boys who consume soft drinks were more likely to be overweight/obese (OR = 1.52). In girls, higher water intake, higher vegetable consumption, and more TV time on weekend days were significantly associated with higher BMI. Girls eating less vegetables than recommended were less likely to be overweight/obese (OR = 0.62), and girls who engaged in quiet play for more than 90 minutes on weekend days were more likely to be overweight/obese (OR = 1.64). In general, the associations between HRB and BMI or being overweight/obese were limited and mainly related to dietary intake. Awareness campaigns for caregivers should stress that HRB of young children are important and independent of children’s weight status. PMID:26950063

  15. Peering into the Black Box: In Situ X Ray SAXS/WAXS/PDF Studies of the Formation and Growth of Inorganic Nanoparticles During Near or Supercritical Synthesis

    International Nuclear Information System (INIS)

    In recent years, the applications of inorganic nanomaterials within the field of energy production and storage have grown. This is spurring a need for synthesis methods that allow a specific tailoring of material properties, e.g. size and size distribution, crystallinity or morphology. One promising candidate to resolve this is wet chemical synthesis at elevated temperatures and pressures, also known as hydrothermal or solvothermal synthesis. Unfortunately, the fundamental chemical processes taking place under these conditions are to a large extent unknown, since they are confined inside a closed reactor/container commonly made of steel. Here, the design, construction and application of two experimental set-ups are presented, both of which allow in situ studies of the chemical reactions going on ‘inside the pressure cooker’ by means of synchrotron X ray radiation. Effectively, they act as video cameras designed for capturing ‘movies’ of the birth, growth and development of nanoparticles inside a reaction environment which has a temperature of 100–600°C and a pressure of several megapascal. The main characterization techniques which make this possible are wide angle X ray scattering (WAXS), Small angle X ray scattering (SAXS), pair distribution function measurements (PDF) and X ray absorption spectroscopy (XAS), applied either separately or simultaneously, e.g. as SAXS/WAXS or WAXS/PDF. Since time resolutions (the ‘frame rates’) are usually <10 seconds, this allows a complete survey of the entire course of a synthesis reaction, right from before the onset of the material formation until the final product is obtained. (author)

  16. Partons of a spherical box

    International Nuclear Information System (INIS)

    Calculation of parton distributions in the 'cavity approximation' to the MIT bag model gives a divergent sum of positive terms. This suggests that Bjorken scaling does not hold for the deep inelastic scattering in this version of the model. (Auth.)

  17. 49 CFR 178.517 - Standards for plastic boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for plastic boxes. 178.517 Section 178... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.517 Standards for plastic boxes. (a) The following are identification codes for plastic boxes: (1) 4H1 for an expanded plastic box; and (2) 4H2 for...

  18. 49 CFR 230.101 - Steam locomotive driving journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Steam locomotive driving journal boxes. 230.101... Locomotives and Tenders Running Gear § 230.101 Steam locomotive driving journal boxes. (a) Driving journal boxes. Driving journal boxes shall be maintained in a safe and suitable condition for service. Not...

  19. 49 CFR 178.514 - Standards for plywood boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Standards for plywood boxes. 178.514 Section 178... PACKAGINGS Non-bulk Performance-Oriented Packaging Standards § 178.514 Standards for plywood boxes. (a) The identification code for a plywood box is 4D. (b) Construction requirements for plywood boxes are as follows:...

  20. Eddy current experiments with closely placed solid boxes simulating a next step fusion device

    International Nuclear Information System (INIS)

    Eddy current experiments with closely placed solid boxes driven by a coil alternative current were carried out. The experiment was to designed to identify approaches to the problems about: (1) computing accuracy of the eddy current calculation with thin plate approximation; and (2) modeling baselines for a computational study of eddy currents in a super conducting (SC) fusion device. The following conclusions were drawn from experimental data and their comparison with eddy current analyses: (1) the skin effect is a major cause of computational error; (2) if the error due to the skin effect cannot be ignored, the double shell model calculates accurate eddy currents; (3) the mesh size with a narrow gap should be small enough (for example smaller than five times the gap width) so as not to cause additional error. The Finite Element Method (FEM) model for the eddy current computation is well modeled using these conclusions

  1. Modeling of preloaded threaded pipe connections

    OpenAIRE

    Van Wittenberghe, Jeroen; DE BAETS, Patrick; De Waele, Wim

    2009-01-01

    In this paper a modeling method to perform parametric studies on preloaded threaded connections is presented. The method uses a non-linear 2D axisymmetric finite element model, and is illustrated by a parametric study of an API Line Pipe connection. The method was used to quantify the influence of the coefficient of friction, the wall thickness of pin and box and the box recess length of the connection.

  2. Motivations of consumers that use local, organic fruit and vegetable box schemes in Central England and Southern France

    OpenAIRE

    Brown, E.; Dury, S.; Holdsworth, Michelle

    2009-01-01

    Commercial fruit and vegetable box schemes are rapidly growing initiatives that allow customers to make local, organic food choices. This Study investigated the socio-demographic profile of consumers using local commercial box schemes, and investigated the barriers and motivations of customers. Cross-sectional surveys using identical questionnaires were conducted in Montpellier, France and Nottingham, England. Box scheme users in both countries were primarily rather affluent professionals. Th...

  3. Genome-wide Analysis of Kelch Repeat-containing F-box Family

    Institute of Scientific and Technical Information of China (English)

    Yujin Sun; Xiaofan Zhou; Hong Ma

    2007-01-01

    The ubiquitin-dependent protein degradation pathway plays diverse roles in eukaryotes. Previous studies indicate that both F-box and Kelch motifs are common in a variety of organisms. F-box proteins are subunits of E3 ubiquitin ligase complexes called SCFs (SKP1, Cullinl, F-box protein, and Rbx1); they have an N-terminal F-box motif that binds to SKP1 (S-phase kinase associated protein), and often have C-terminal protein-protein interaction domains, which specify the protein substrates for degradation via the ubiquitin pathway. One of the most frequently found protein interaction domains in F-box proteins is the Kelch repeat domain. Although both the F-box and Kelch repeats are ancient motifs, Kelch repeats-containing F-box proteins (KFB) have only been reported for human and Arabidopsis previously. The recent sequencing of the rice genome and other plant genomes provides an opportunity to examine the possible evolution history of KFB. We carried out extensive BLAST searches to identify putative KFBs in selected organisms, and analyzed their relationships phylogenetically. We also carried out the analysis of both gene duplication and gene expression of the KFBs in rice and Arabidopsis. Our study indicates that the origin of KFBs occurs before the divergence of animals and plants, and plant KFBs underwent rapid gene duplications.

  4. Finding External Indicators of Load on a Web Server via Analysis of Black-Box Performance Measurements

    Science.gov (United States)

    Chiarini, Marc A.

    2010-01-01

    Traditional methods for system performance analysis have long relied on a mix of queuing theory, detailed system knowledge, intuition, and trial-and-error. These approaches often require construction of incomplete gray-box models that can be costly to build and difficult to scale or generalize. In this thesis, we present a black-box analysis…

  5. The Virtual Solar Observatory: Still a Small Box

    Science.gov (United States)

    Gurman, J. B.; Bogart, R. S.; Davey, A. R.; Dimitoglou, G.; Hill, F.; Hourcle, J. A.; Martens, P. C.; Surez-Sola, I.; Tian, K. Q.; Wampler, S.

    2005-01-01

    Two and a half years after a design study began, and a year and a half after development commenced, version 1.0 of the Virtual Solar Observatory (VSO) was released at the 2004 Fall AGU meeting. Although internal elements of the VSO have changed, the basic design has remained the same, reflecting the team's belief in the importance of a simple, robust mechanism for registering data provider holdings, initiating queries at the appropriate provider sites, aggregating the responses, allowing the user to iterate before making a final selection, and enabling the delivery of data directly from the providers. In order to make the VSO transparent, lightweight, and portable, the developers employed XML for the registry, SOAP for communication between a VSO instance and data services, and HTML for the graphic user interface (GUI's). We discuss the internal data model, the API, and user responses to various trial GUI's as typical design issues for any virtual observatory. We also discuss the role of the "small box" of data search, identification, and delivery services provided by the VSO in the larger, Sun-Solar System Connection virtual observatory (VxO) scheme.

  6. Mesoscopic Anderson Box: Connecting Weak to Strong Coupling

    Science.gov (United States)

    Liu, Dong E.; Burdin, Sebastien; Baranger, Harold U.; Ullmo, Denis

    2011-03-01

    Both the weakly coupled and strong coupling Anderson impurity problem are characterized by a Fermi-liquid theory with weakly interacting quasiparticles. In an Anderson box, mesoscopic fluctuations of the effective single particle properties will be large. We study how the statistical fluctuations in these two problems are connected. We use random matrix theory and the slave boson mean field approximation (SBMF, at low temperature) to address this question, obtaining the following results. First, for a resonant level model such as results from the SBMF approximation, we find the joint distribution of energy levels with and without the resonant level present. Second, if only energy levels within the Kondo resonance are considered, the distribution of perturbed levels collapse to one universal form for both GOE and GUE for all values of the coupling V. Finally, a purely Fermi liquid method is developed for calculating the perturbed levels within the Kondo resonance. Comparing the levels that result to those of the SBMF, we find remarkable agreement.

  7. Pharmacy Students’ Knowledge of Black Box Warnings

    Science.gov (United States)

    Shireman, Theresa I.; Generali, Joyce; Rigler, Sally; Mayorga, Angela

    2010-01-01

    Objective To evaluate the progression of pharmacy students’ knowledge of black box warnings across 3 years of didactic training, and to determine how they stay current with new warnings. Methods A cross-sectional survey instrument was administered to pharmacy students in their first (P1), second (P2), and third (P3) professional years. The survey assessed student awareness of medications possessing a black box warning and familiarity with the warning content for 20 medications (15 with and 5 without warnings). Results Mean number of correct responses identifying the presence or absence of a black box warning among the 20 medications were 5.8 ± 3.3, 9.6 ± 4.0, and 14.8 ± 2.8 for the P1, P2, and P3 students, respectively. Knowledge of black box warning content was variable. Students were least aware of the warning content for stavudine and enoxaparin. Students were most familiar with the warning content for paroxetine and estrogen. Conclusion Students’ awareness and understanding of black box warnings was proportional to their educational progression, but their knowledge level was inconsistent across drug groups. PMID:20221356

  8. Studies of Catalytic Model Systems

    DEFF Research Database (Denmark)

    Holse, Christian

    the Cu/ZnO nanoparticles is highly relevant to industrial methanol synthesis for which the direct interaction of Cu and ZnO nanocrystals synergistically boost the catalytic activity. The dynamical behavior of the nanoparticles under reducing and oxidizing environments were studied by means of ex situ...... observed by XPS as the nanoparticles are reduced. The Cu/ZnO nanoparticles are tested on a  µ-reactor platform and prove to be active towards methanol synthesis, making it an excellent model system for further investigations into activity depended morphology changes....

  9. Salmonella in pig lairage and in stunning box

    OpenAIRE

    Karabasil Neđeljko; Dimitrijević Mirjana; Pavlićević Nataša; Teodorović Vlado; Lončina Jasna; Nedeljković-Trailović Jelena; Baltić Milan Ž.

    2012-01-01

    Salmonella is one of the most important zoonotic pathogens and the consumption of pork meat is a major source of human infection. The aim of this study was to investigate the presence of Salmonella on different surfaces in the pig lairage and stunning box as potential sources of cross contamination of animals and carcasses. Sampling was conducted in two abattoirs (slaughterhouse A and slaughterhouse B). Samples were taken from slaughterhouse A in two instan...

  10. Wing box transonic-flutter suppression using piezoelectric self-sensing actuators attached to skin

    International Nuclear Information System (INIS)

    The main objective of this research is to study the capability of piezoelectric (PZT) self-sensing actuators to suppress the transonic wing box flutter, which is a flow–structure interaction phenomenon. The unsteady general frequency modified transonic small disturbance (TSD) equation is used to model the transonic flow about the wing. The wing box structure and piezoelectric actuators are modeled using the equivalent plate method, which is based on the first order shear deformation plate theory (FSDPT). The piezoelectric actuators are bonded to the skin. The optimal electromechanical coupling conditions between the piezoelectric actuators and the wing are collected from previous work. Three main different control strategies, a linear quadratic Gaussian (LQG) which combines the linear quadratic regulator (LQR) with the Kalman filter estimator (KFE), an optimal static output feedback (SOF), and a classic feedback controller (CFC), are studied and compared. The optimum actuator and sensor locations are determined using the norm of feedback control gains (NFCG) and norm of Kalman filter estimator gains (NKFEG) respectively. A genetic algorithm (GA) optimization technique is used to calculate the controller and estimator parameters to achieve a target response

  11. NURE uranium deposit model studies

    International Nuclear Information System (INIS)

    The National Uranium Resource Evaluation (NURE) Program has sponsored uranium deposit model studies by Bendix Field Engineering Corporation (Bendix), the US Geological Survey (USGS), and numerous subcontractors. This paper deals only with models from the following six reports prepared by Samuel S. Adams and Associates: GJBX-1(81) - Geology and Recognition Criteria for Roll-Type Uranium Deposits in Continental Sandstones; GJBX-2(81) - Geology and Recognition Criteria for Uraniferous Humate Deposits, Grants Uranium Region, New Mexico; GJBX-3(81) - Geology and Recognition Criteria for Uranium Deposits of the Quartz-Pebble Conglomerate Type; GJBX-4(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits in Mixed Fluvial-Shallow Marine Sedimentary Sequences, South Texas; GJBX-5(81) - Geology and Recognition Criteria for Veinlike Uranium Deposits of the Lower to Middle Proterozoic Unconformity and Strata-Related Types; GJBX-6(81) - Geology and Recognition Criteria for Sandstone Uranium Deposits of the Salt Wash Type, Colorado Plateau Province. A unique feature of these models is the development of recognition criteria in a systematic fashion, with a method for quantifying the various items. The recognition-criteria networks are used in this paper to illustrate the various types of deposits

  12. Epidemiologic determinants of aural abscessation in free-living eastern box turtles (Terrapene carolina) in Virginia.

    Science.gov (United States)

    Brown, Justin D; Sleeman, Jonathan M; Elvinger, François

    2003-10-01

    Epidemiologic determinants of 46 cases of aural abscessation in free-living eastern box turtles (Terrapene carolina) admitted to the Wildlife Center of Virginia (Virginia, USA) from 1991 to 2000 were evaluated. County human population density, year and season of admission, weight, and sex did not affect the risk for box turtles to develop aural abscessation. Counties with cases of aural abscessation were not randomly distributed, but rather were clustered into two multi-county regions. Geographic location was the only risk factor associated with aural abscessation in box turtles found in this study. Possible etiologies could include chronic infectious disease, malnutrition, or chronic exposure to environmental contamination with organochlorine compounds. PMID:14733291

  13. Stepwise bending of DNA by a single TATA box binding protein

    DEFF Research Database (Denmark)

    Tolic-Nørrelykke, Simon F; Rasmussen, Mette B; Pavone, Francesco S;

    2006-01-01

    The TATA-box binding protein (TBP) is required by all three eucaryotic RNA polymerases for the initiation of transcription from most promoters. TBP recognizes, binds to, and bends promoter sequences called "TATA-boxes" in the DNA. We present results from the study of individual Saccharomyces...... cerevisiae TBPs interacting with single DNA molecules containing a TATA-box. Using video microscopy, we observed the Brownian motion of the beads tethered by short surface-bound DNA. When TBP binds to and bends the DNA, the conformation of the DNA changes and the amplitude of Brownian motion of the tehtered...

  14. Streptococcus pneumoniae Genome-wide Identification and Characterization of BOX Element-binding Domains.

    Science.gov (United States)

    Zhang, Qiao; Wang, Changzheng; Wan, Min; Wu, Yin; Ma, Qianli

    2015-11-01

    The BOX elements are short repetitive DNA sequences that distribute randomly in intergenic regions of the Streptococcus pneumoniae genome. The function and origin of such elements are still unknown, but they were found to modulate expression of neighboring genes. Evidences suggested that the modulation's mechanism can be fulfilled by sequence-specific interaction of BOX elements with transcription factor family proteins. However, the type and function of these BOX-binding proteins still remain largely unexplored to date. In the current study we described a synthetic protocol to investigate the recognition and interaction between a highly conserved site of BOX elements and the DNA-binding domains of a variety of putative transcription factors in the pneumococcal genome. With the protocol we were able to predict those high-affinity domain binders of the conserved BOX DNA site (BOX DNA) in a high-throughput manner, and analyzed sequence-specific interaction in the domainDNA recognition at molecular level. Consequently, a number of putative transcription factor domains with both high affinity and specificity for the BOX DNA were identified, from which the helix-turn-helix (HTH) motif of a small heat shock factor was selected as a case study and tested for its binding capability toward the double-stranded BOX DNA using fluorescence anisotropy analysis. As might be expected, a relatively high affinity was detected for the interaction of HTH motif with BOX DNA with dissociation constant at nanomolar level. Molecular dynamics simulation, atomic structure examination and binding energy analysis revealed a complicated network of intensive nonbonded interactions across the complex interface, which confers both stability and specificity for the complex architecture. PMID:27491035

  15. E box motifs as mediators of proviral latency of human retroviruses

    Directory of Open Access Journals (Sweden)

    Gazzolo Louis

    2009-09-01

    Full Text Available Abstract The palindromic sequence motifs (CANNTG known as E boxes are considered as binding sites for the basic helix-loop-helix (bHLH class of DNA-binding proteins. Their presence has been reported in the long terminal repeats (LTR of the HIV-1 and HTLV-1 proviruses. Their close proximity with the TATA region of both LTRs indicates that the bHLH proteins may act as important regulators of the function of proviral transcription. Indeed, observations on HIV-1 and recent results on HTLV-1 underline that these E boxes may be critically involved in the regulation of the proviral transcription of these human retroviruses. Indeed, of the two E boxes flanking the TATA sequences of the HIV-1 provirus, the 3' E box has been implicated in the transcriptional inhibition of viral gene expression. Such a role might also be played by the unique 5' E box present in the HTLV-1 LTR. In both cases, the expression of tissue-specfic bHLH proteins, like TAL1 might counteract the inhibitory effect exerted by E box proteins, thereby increasing proviral transcription. Finally, a phylogenetic study encompassing several subtypes of these two human retroviruses underlines that these E box motifs have recently appeared in the proviral LTRs and may be considered as potential mediators in the establishment of proviral latency.

  16. Co-expression and co-purification of archaeal and eukaryal box C/D RNPs.

    Directory of Open Access Journals (Sweden)

    Yu Peng

    Full Text Available Box C/D ribonucleoprotein particles (RNPs are 2'-O-methylation enzymes required for maturation of ribosomal and small nuclear RNA. Previous biochemical and structural studies of the box C/D RNPs were limited by the unavailability of purified intact RNPs. We developed a bacterial co-expression strategy based on the combined use of a multi-gene expression system and a tRNA-scaffold construct that allowed the expression and purification of homogeneous archaeal and human box C/D RNPs. While the co-expressed and co-purified archaeal box C/D RNP was found to be fully active in a 2'-O-methylation assay, the intact human U14 box C/D RNP showed no detectable catalytic activity, consistent with the earlier findings that assembly of eukaryotic box C/D RNPs is nonspontaneous and requires additional protein factors. Our systems provide a means for further biochemical and structural characterization of box C/D RNPs and their assembly factors.

  17. Saturation of the magnetorotational instability in the unstratified shearing box with zero net flux: convergence in taller boxes

    CERN Document Server

    Shi, Ji-Ming; Huang, Chelsea X

    2015-01-01

    Previous studies of the nonlinear regime of the magnetorotational instability in one particular type of shearing box model -- unstratified with no net magnetic flux -- find that without explicit dissipation (viscosity and resistivity) the saturation amplitude decreases with increasing numerical resolution. We show that this result is strongly dependent on the vertical aspect ratio of the computational domain $L_z/L_x$. When $L_z/L_x\\lesssim 1$, we recover previous results. However, when the vertical domain is extended $L_z/L_x \\gtrsim 2.5$, we find the saturation level of the stress is greatly increased (giving a ratio of stress to pressure $\\alpha \\gtrsim 0.1$), and moreover the results are independent of numerical resolution. Consistent with previous results, we find that saturation of the MRI in this regime is controlled by a cyclic dynamo which generates patches of strong toroidal field that switches sign on scales of $L_x$ in the vertical direction. We speculate that when $L_z/L_x\\lesssim 1$, the dynamo ...

  18. Nearly Seamless Vacuum-Insulated Boxes

    Science.gov (United States)

    Stepanian, Christopher J.; Ou, Danny; Hu, Xiangjun

    2010-01-01

    A design concept, and a fabrication process that would implement the design concept, have been proposed for nearly seamless vacuum-insulated boxes that could be the main structural components of a variety of controlled-temperature containers, including common household refrigerators and insulating containers for shipping foods. In a typical case, a vacuum-insulated box would be shaped like a rectangular parallelepiped conventional refrigerator box having five fully closed sides and a hinged door on the sixth side. Although it is possible to construct the five-closed-side portion of the box as an assembly of five unitary vacuum-insulated panels, it is not desirable to do so because the relatively high thermal conductances of the seams between the panels would contribute significant amounts of heat leakage, relative to the leakage through the panels themselves. In contrast, the proposal would make it possible to reduce heat leakage by constructing the five-closed-side portion of the box plus the stationary portion (if any) of the sixth side as a single, seamless unit; the only remaining seam would be the edge seal around the door. The basic cross-sectional configuration of each side of a vacuum-insulated box according to the proposal would be that of a conventional vacuum-insulated panel: a low-density, porous core material filling a partially evacuated space between face sheets. However, neither the face sheets nor the core would be conventional. The face sheets would be opposite sides of a vacuum bag. The core material would be a flexible polymer-modified silica aerogel of the type described in Silica/Polymer and Silica/Polymer/Fiber Composite Aero - gels (MSC-23736) in this issue of NASA Tech Briefs. As noted in that article, the stiffness of this core material against compression is greater than that of prior aerogels. This is an important advantage because it translates to greater retention of thickness and, hence, of insulation performance when pressure is

  19. Advances in the theory of box integrals

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, J.M.; Crandall, R.E.

    2009-06-25

    Box integrals - expectations <|{rvec r}|{sup s}> or <|{rvec r}-{rvec q}|{sup s}> over the unit n-cube (or n-box) - have over three decades been occasionally given closed forms for isolated n,s. By employing experimental mathematics together with a new, global analytic strategy, we prove that for n {le} 4 dimensions the box integrals are for any integer s hypergeometrically closed in a sense we clarify herein. For n = 5 dimensions, we show that a single unresolved integral we call K{sub 5} stands in the way of such hyperclosure proofs. We supply a compendium of exemplary closed forms that naturally arise algorithmically from this theory.

  20. The quantum query complexity of implementing black-box unitary transformations

    CERN Document Server

    Berry, Dominic W

    2009-01-01

    Standard methods for performing an arbitrary $N\\times N$ unitary operation use $\\tilde O(N^2)$ elementary gates. We consider a related problem, the implementation of a unitary operation given a black-box description of its matrix elements. In this model, we show that any unitary can be performed with bounded error using $O(N^{2/3} (\\log\\log N)^{4/3})$ queries. In fact, except for pathological cases, it appears that most unitaries can be performed with only $\\tilde O(\\sqrt{N})$ queries, which is optimal. Our implementation of black-box unitaries is based on general methods for black-box state preparation and black-box Hamiltonian simulation that may be of interest in their own right.

  1. Free box^k Scalar Conformal Field Theory

    CERN Document Server

    Brust, Christopher

    2016-01-01

    We consider the generalizations of the free U(N) and O(N) scalar conformal field theories to actions with higher powers of the Laplacian, box^k, in general dimension d. We study the spectra, Verma modules, anomalies and OPE of these theories. We argue that in certain d and k, the spectrum contains zero norm operators which are both primary and descendant, as well as extension operators which are neither primary nor descendant. In addition, we argue that in even dimensions d <= 2k, there are well-defined operator algebras which are related to the box^k theories and are novel in that they have a finite number of single-trace states.

  2. Safeguards Approaches for Black Box Processes or Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Marcano, Helly; Gitau, Ernest TN; Hockert, John; Miller, Erin; Wylie, Joann

    2013-09-25

    The objective of this study is to determine whether a safeguards approach can be developed for “black box” processes or facilities. These are facilities where a State or operator may limit IAEA access to specific processes or portions of a facility; in other cases, the IAEA may be prohibited access to the entire facility. The determination of whether a black box process or facility is safeguardable is dependent upon the details of the process type, design, and layout; the specific limitations on inspector access; and the restrictions placed upon the design information that can be provided to the IAEA. This analysis identified the necessary conditions for safeguardability of black box processes and facilities.

  3. Fire test of DOT 7A Boxes

    International Nuclear Information System (INIS)

    The primary objective of conducting the full-scale fire tests of the DOT (Department of Transportation) 7A FRP Boxes was to provide information to assist in quantifying the fire hazard of the storage located at the Radioactive Waste Management Complex (RWMC), and to learn if changing the storage array will decrease the fire risk. Also, the level of fire fighting and fire protection required to maintain the risk at the RWMC within acceptable DOE guidelines was investigated. Two full-scale fire tests were conducted at Southwest Research Institute (SwRI) in June 1978, using the DOE 7A FRP Plywood Storage Containers. The fire tests showed that when subjected to a substantial ignition source, the boxes will propagate fire as long as no fire-suppression measures are taken. Fire will breach the boxes and spread the radioactive contaminated waste if it is not extinguished. As the fire progresses, additional boxes will become involved, and eventually the entire storage array will ignite. It is recommended that the use of DOT 7A Boxes be discontinued and replaced with noncombustible storage containers. In the event this is not practicable, guidance recommendations are presented to minimize the large fire loss potential. It is also recommended that an investigation be conducted into the number of boxes that can be destroyed and still maintain a safe environment for employees and the public. This investigation should include how far radioactive contamination will spread, what cleanup will be required, anticipated exposure of the people within the area, and the public impact of such a fire

  4. Testing of packings for stuffing boxes

    International Nuclear Information System (INIS)

    The stuffing box packings function when they are sealed tight and do not obstruct the movement of the spindle. Characteristic values are necessary to characterise the materials properties of stuffing box packings. Essentially, the definitions of the characteristic values are known and can be calculated in experimental setups. It is absolutely necessary to standardise the characteristic values as well as the testing procedures in order to be able to provide comparable and reproduceable characteristic values. Depending upon the importance of the fittings, it is necessary to guarantee sufficiently exact and reliable assembly for defined operating conditions. (orig.)

  5. A study on the experiment of kick-boxing aerobics in the aerobics teaching of boy students in colleges and universities%有氧搏击操在普通高校男生健美操教学中的实验研究

    Institute of Scientific and Technical Information of China (English)

    陈善凤

    2009-01-01

    Through study on the application of kick-boxing aerobics in the aerobics teaching of boy students in colleges and universities, this article gets the results that the kick-boxing aerobics is not only effective to develop the interesting of study aerobics and strengthen their physical quality, but also improve the popularity of the aerobics in boy students.%对有氧搏击操在普通高校男生健美操教学中的应用进行研究,结果表明:有氧搏击操锻炼不仅能有效提高男生学习健美操的兴趣,增强其身体素质,而且还能促进健美操在高校男生中的普及.

  6. Analysis of isotropic turbulence using a public database and the Web service model, and applications to study subgrid models

    Science.gov (United States)

    Meneveau, Charles; Yang, Yunke; Perlman, Eric; Wan, Minpin; Burns, Randal; Szalay, Alex; Chen, Shiyi; Eyink, Gregory

    2008-11-01

    A public database system archiving a direct numerical simulation (DNS) data set of isotropic, forced turbulence is used for studying basic turbulence dynamics. The data set consists of the DNS output on 1024-cubed spatial points and 1024 time-samples spanning about one large-scale turn-over timescale. This complete space-time history of turbulence is accessible to users remotely through an interface that is based on the Web-services model (see http://turbulence.pha.jhu.edu). Users may write and execute analysis programs on their host computers, while the programs make subroutine-like calls that request desired parts of the data over the network. The architecture of the database is briefly explained, as are some of the new functions such as Lagrangian particle tracking and spatial box-filtering. These tools are used to evaluate and compare subgrid stresses and models.

  7. Opening up a Colourful Cosmic Jewel Box

    Science.gov (United States)

    2009-10-01

    The combination of images taken by three exceptional telescopes, the ESO Very Large Telescope on Cerro Paranal , the MPG/ESO 2.2-metre telescope at ESO's La Silla observatory and the NASA/ESA Hubble Space Telescope, has allowed the stunning Jewel Box star cluster to be seen in a whole new light. Star clusters are among the most visually alluring and astrophysically fascinating objects in the sky. One of the most spectacular nestles deep in the southern skies near the Southern Cross in the constellation of Crux. The Kappa Crucis Cluster, also known as NGC 4755 or simply the "Jewel Box" is just bright enough to be seen with the unaided eye. It was given its nickname by the English astronomer John Herschel in the 1830s because the striking colour contrasts of its pale blue and orange stars seen through a telescope reminded Herschel of a piece of exotic jewellery. Open clusters [1] such as NGC 4755 typically contain anything from a few to thousands of stars that are loosely bound together by gravity. Because the stars all formed together from the same cloud of gas and dust their ages and chemical makeup are similar, which makes them ideal laboratories for studying how stars evolve. The position of the cluster amongst the rich star fields and dust clouds of the southern Milky Way is shown in the very wide field view generated from the Digitized Sky Survey 2 data. This image also includes one of the stars of the Southern Cross as well as part of the huge dark cloud of the Coal Sack [2]. A new image taken with the Wide Field Imager (WFI) on the MPG/ESO 2.2-metre telescope at ESO's La Silla Observatory in Chile shows the cluster and its rich surroundings in all their multicoloured glory. The large field of view of the WFI shows a vast number of stars. Many are located behind the dusty clouds of the Milky Way and therefore appear red [3]. The FORS1 instrument on the ESO Very Large Telescope (VLT) allows a much closer look at the cluster itself. The telescope's huge mirror

  8. Determination of the calibration curve for an ST5 box containing baled waste

    International Nuclear Information System (INIS)

    The Trash Monitor Station (TMS), a nondestructive examination facility at the Oak Ridge Y-12 Plant, utilizes gamma scintillation detectors for the isotopic characterization of possible radioactive contamination and measurement of the quantity of potential depleted uranium contamination present in solid waste. Experimental data has been collected and analyzed for construction of a calibration curve for an ST5 box containing baled waste. The raw data consists of gross counts per second derived from five minute counts from three TMS sodium iodide detectors when known amounts of depleted uranium have been placed in a predetermined ''worst case'' location. Extensive analysis of the data indicates that a function of the form y = a + bx + cx1/2, where x and y represent sources and net counts per minute respectively, provides the best characterization of a calibration curve. While this equation provides the best prediction, an established method for calculating the minimum detectable amount (MDA) for this type of equation has notbeen found. Therefore, a piece-wise fit of two lines may be preferable at this time. This study provides two linear and two nonlinear models, any one of which may be appropriate for use as the calibration equation for an ST5 box containing baled waste. Two equations for both the linear and nonlinear model types have been supplied to provide a choice between using cpm from a third sodium iodide detector as background or using cpm from a different region of interest as background

  9. A RESEARCH ON HEALTHY LIVING BEHAVIORS OF ARCHERY COACHES AND BOXING COACHES

    Directory of Open Access Journals (Sweden)

    Ziya Bahadır

    2014-07-01

    Full Text Available The aim of the research was to assess healthy living behaviors of archery coaches and boxing coaches in terms of sportive branch, sportive experience and gender. The study was conducted with boxing coaches (n=119 and archery coaches (n=131. As the data collection tool; “ The Health - Promoting Lifestyle Profile II (HPLP - II which was developed by Walker et al . and validity and reliability tests of which were performed by Bahar et al . (2008 was employed. In the study; it was found out that mean score of boxing coaches on P hysical activity subscale was higher than archery coaches . Besides; no statistically significant difference s existed between archery coaches and boxing coaches in terms of gender and sportive experience.

  10. Saltstone SDU6 Modeling Study

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Si Y. [Savannah River Site (SRS), Aiken, SC (United States); Hyun, Sinjae [Mercer University, Macon, GA (United States)

    2013-01-10

    A new disposal unit, designated as Saltstone Disposal Unit 6 (SDU6), is being designed for support of site accelerated closure goals and salt waste projections identified in the new Liquid Waste System Plan. The unit is a cylindrical disposal cell of 375 ft in diameter and 43 ft in height, and it has a minimum 30 million gallons of capacity. SRNL was requested to evaluate the impact of an increased grout placement height on the flow patterns radially spread on the floor and to determine whether grout quality is impacted by the height. The primary goals of the work are to develop the baseline Computational Fluid Dynamics (CFD) model and to perform the evaluations for the flow patterns of grout material in SDU6 as a function of elevation of grout discharge port and grout rheology. Two transient grout models have been developed by taking a three-dimensional multiphase CFD approach to estimate the domain size of the grout materials radially spread on the facility floor and to perform the sensitivity analysis with respect to the baseline design and operating conditions such as elevation height of the discharge port and fresh grout properties. For the CFD modeling calculations, air-grout Volume of Fluid (VOF) method combined with Bingham plastic and time-dependent grout models were used for examining the impact of fluid spread performance for the initial baseline configurations and to evaluate the impact of grout pouring height on grout quality. The grout quality was estimated in terms of the air volume fraction for the grout layer formed on the SDU6 floor, resulting in the change of grout density. The study results should be considered as preliminary scoping analyses since benchmarking analysis is not included in this task scope. Transient analyses with the Bingham plastic model were performed with the FLUENTTM code on the high performance parallel computing platform in SRNL. The analysis coupled with a transient grout aging model was performed by using ANSYS-CFX code

  11. Fano-Kondo and the Kondo box regimes crossover in a quantum dot coupled to a quantum box.

    Science.gov (United States)

    Apel, Victor M; Orellana, Pedro A; Pacheco, Monica; Anda, Enrique V

    2013-12-18

    In this work, we study the Kondo effect of a quantum dot (QD) connected to leads and to a discrete set of one-particle states provided by a quantum box represented by a quantum ring (QR) pierced by a magnetic flux side attached to the QD. The interplay between the bulk Kondo effect and the so-called Kondo box regime is studied. In this system the QR energies can be continuously modified by the application of the magnetic field. The crossover between these two regimes is analyzed by changing the connection of the QD to the QR from the weak to the strong coupling regime. In the weak coupling regime, the differential conductance develops a sequence of Fano-Kondo anti-resonances due to destructive interference between the discrete quantum ring levels and the conducting Kondo channel provided by the leads. In the strong coupling regime the differential conductance has very sharp resonances when one of the Kondo discrete sub-levels characterizing the Kondo box is tuned by the applied potential. The conductance, the current fluctuations and the Fano coefficient result as being the relevant physical magnitudes to be analyzed to reveal the physical properties of these two Kondo regimes and the crossover region between them. The results were obtained by using the slave boson mean field theory (SBMFT). PMID:24275637

  12. Monitorization of drug content in furosemide and lorazepam tablets stored in multidose pill boxes

    OpenAIRE

    Jessica Martins; Magda Oliveira; Maria Tapiço; Tânia Nascimento; Ana Grenha; Luis Braz

    2010-01-01

    Background : Therapeutic nonadherence is a major health problem, particularly when therapeutic regimens are complex and long-lasting. Therefore, tools such as multidose pill boxes have been designed to provide the means for higher therapeutic compliance. However, no studies are available reporting on their capacity to keep the drug content of the stored tablets unaltered. Objective : This work aimed at monitoring the drug content of tablets stored in multidose boxes for a period of two weeks....

  13. Opening the black box: How staff training and development may affect the innovation of enterprises

    OpenAIRE

    Mate, Davide; Carpaneto, Alberto; Tirassa, Corrado; Brizio, Adelina; Rezzonico, Raffaele; Brassesco, Barbara; Surra, Fabio; Rabellino, Daniela; Tirassa, Maurizio

    2010-01-01

    We describe a research on the interplay that appears to exist in companies between Human Resource Management and innovation. This complex, multicomponent, non-linear and dynamic interplay is often viewed as a "black box". To help open the black box, we outline both a theoretical framework and preliminary empirical data. We view innovation as an organization-level property, favored by the organization's self-perception as a knowledge engine. Therefore, we devised a protocol to study the compan...

  14. Cereal Box Design: An Interdisciplinary Graphics Activity

    Science.gov (United States)

    Fitzgerald, Mike; Tsosie, Teri

    2012-01-01

    The cereal box design activity is intriguing both for its simplicity and the resourcefulness that it can generate in young people. Also, it lends itself to a variety of curriculums. It covers both consumerism and Design for the Environment (DfE) concepts broadly and in depth. The activity introduces a wide range of topics. They include graphic…

  15. Black hole formation in a box

    International Nuclear Information System (INIS)

    Evidence is presented for Hawking's viewpoint that in an insulated box in thermal equilibrium, black holes should form and evaporate in a statistically time-symmetric way. In particular, it is shown that if a black hole can evaporate adiabatically, it is much more likely to form adiabatically than by Jeans instability. (author)

  16. Safety evaluation for packaging CPC metal boxes

    International Nuclear Information System (INIS)

    This Safety Evaluation for Packaging (SEP) provides authorization for the use of Container Products Corporation (CPC) metal boxes, as described in this document, for the interarea shipment of radioactive contaminated equipment and debris for storage in the Central Waste Complex (CWC) or T Plant located in the 200 West Area. Authorization is granted until November 30, 1995. The CPC boxes included in this SEP were originally procured as US Department of Transportation (DOT) Specification 7A Type A boxes. A review of the documentation provided by the manufacturer revealed the documentation did not adequately demonstrate compliance to the 4 ft drop test requirement of 49 CFR 173.465(c). Preparation of a SEP is necessary to document the equivalent safety of the onsite shipment in lieu of meeting DOT packaging requirements until adequate documentation is received. The equivalent safety of the shipment is based on the fact that the radioactive contents consist of contaminated equipment and debris which are not dispersible. Each piece is wrapped in two layers of no less than 4 mil plastic prior to being placed in the box which has an additional 10 mil liner. Pointed objects and sharp edges are padded to prevent puncture of the plastic liner and wrapping

  17. Choreographies with Secure Boxes and Compromised Principals

    DEFF Research Database (Denmark)

    Carbone, Marco; Guttman, Joshua

      We equip choreography-level session descriptions with a simple abstraction of a security infrastruc- ture. Message components may be enclosed within (possibly nested) ”boxes” annotated with the intended source and destination of those components. The boxes are to be implemented with cryp...

  18. Nondestructive assay of boxed radioactive waste

    International Nuclear Information System (INIS)

    This paper describes the problems related to the nondestructive assay (NDA) of boxed radioactive waste at the Hanford Site and how Westinghouse Hanford company (WHC) is solving the problems. The waste form and radionuclide content are described. The characteristics of the combined neutron and gamma-based measurement system are described

  19. A white box perspective on behavioural adaptation

    DEFF Research Database (Denmark)

    Bruni, Roberto; Corradini, Andrea; Gadducci, Fabio; Lluch Lafuente, Alberto; Vandin, Andrea

    We present a white-box conceptual framework for adaptation developed in the context of the EU Project ASCENS coordinated by Martin Wirsing. We called it CoDA, for Control Data Adaptation, since it is based on the notion of control data. CoDA promotes a neat separation between application and...

  20. PVC posting bags for glove boxes

    International Nuclear Information System (INIS)

    This specification covers the materials, measurements and manufacture of unpigmented PVC posting bags for use on glove boxes, together with methods of testing the materials. These bags are used in the handling of radioactive and toxic materials of a hazardous nature and therefore must be of the highest standard of mechanical strength, leak tightness and general finish. (author)

  1. Somatotype analysis of elite boxing athletes compared with nonathletes for sports physiotherapy.

    Science.gov (United States)

    Noh, Ji-Woong; Kim, Ju-Hyun; Kim, Mee-Young; Lee, Jeong-Uk; Lee, Lim-Kyu; Park, Byoung-Sun; Yang, Seung-Min; Jeon, Hye-Joo; Lee, Won-Deok; Kwak, Taek-Yong; Jang, Sung-Ho; Lee, Tae-Hyun; Kim, Ju-Young; Kim, Junghwan

    2014-08-01

    [Purpose] The purpose of this study was to show somatotype and physical characteristic differences between elite boxing athletes and non-athletes. [Methods] The somatotypes of 23 elite boxing athletes and 23 nonathletes were measured with the Heath-Carter method. The subjects were divided into four weight divisions as follows: lightweight, light middleweight, middleweight, and heavyweight class. [Results] The endomorphic component values of the boxing athletes were lower than those of the nonathletes. However, the mesomorphic component values of the boxing athletes were higher than those of the nonathletes. There was no significant difference in the ectomorphic component between the two groups. The higher weight divisions tended to have higher values of height, weight, and BMI than the lower weight divisions. The higher weight divisions also tended to have higher values for the endomorphic and mesomorphic components and a lower value for the ectomorphic component than the lower weight divisions. The group of nonathletes consisted of eight endomorphs, four mesomorphs, six ectomorphs, and five central types. Among the boxing athletes, there were 16 mesomorphic, four ectomorphic, and two central types and one endomorphic type. Subdividing the athletes into 13 somatotypes resulted in five balanced mesomorphs, five endomorphic mesomorphs, five mesomorph-ectomorphs, three mesomorph-endomorphs, two mesomorphic ectomorphs, two central types, and one ectomorphic mesomorph type. [Conclusion] The data from this study provides in part physical characteristics of elite boxing athletes that can be used to establish a reference for systemic study of sports physiotherapy. PMID:25202187

  2. The effect of box preparation on the strength of glass fiber-reinforced composite inlay-retained fixed partial dentures

    NARCIS (Netherlands)

    Ozcan, M; Breuklander, MH; Vallittu, PK

    2005-01-01

    Statement of problem. Nonstandardized box dimensions for inlay-retained fixed partial dentures (FPDs) may result in uneven distribution of the forces on the connector region of such restorations. Purpose. The objective of this in vitro study was to evaluate the effect of box dimensions on the initia

  3. The effect of box preparation on the strength of glass fiber–reinforced composite inlay-retained fixed partial dentures

    NARCIS (Netherlands)

    Özcan, Mutlu; Breuklander, Marijn H.; Vallittu, Pekka K.

    2005-01-01

    Statement of problem. Nonstandardized box dimensions for inlay-retained fixed partial dentures (FPDs) may result in uneven distribution of the forces on the connector region of such restorations. Purpose. The objective of this in vitro study was to evaluate the effect of box dimensions on the initia

  4. The Effects of Word Box Instruction on Acquisition, Generalization, and Maintenance of Decoding and Spelling Skills for First Graders

    Science.gov (United States)

    Alber-Morgan, Sheila R.; Joseph, Laurice M.; Kanotz, Brittany; Rouse, Christina A.; Sawyer, Mary R.

    2016-01-01

    This study examined the effects of implementing word boxes as a supplemental instruction method on the acquisition, maintenance, and generalization of word identification and spelling. Word box intervention consists of using manipulatives to learn phonological decoding skills. The participants were three African-American urban first graders…

  5. Mafia in the ballot box

    OpenAIRE

    Giuseppe De Feo; Giacomo De Luca

    2013-01-01

    We study the impact of organized crime on electoral competition. Assuming that the mafia is able to bring votes to the supported party in exchange of money, we show that (i) the strongest party is willing to pay the highest price to secure mafia services; (ii) the volume of electoral trade with the mafia increases with political competition and with the efficiency of the mafia. Studying in detail parliamentary elections in Sicily for the period 1946- 1992, we document the significant support ...

  6. Monte Carlo simulation experiments on box-type radon dosimeter

    Science.gov (United States)

    Jamil, Khalid; Kamran, Muhammad; Illahi, Ahsan; Manzoor, Shahid

    2014-11-01

    Epidemiological studies show that inhalation of radon gas (222Rn) may be carcinogenic especially to mine workers, people living in closed indoor energy conserved environments and underground dwellers. It is, therefore, of paramount importance to measure the 222Rn concentrations (Bq/m3) in indoors environments. For this purpose, box-type passive radon dosimeters employing ion track detector like CR-39 are widely used. Fraction of the number of radon alphas emitted in the volume of the box type dosimeter resulting in latent track formation on CR-39 is the latent track registration efficiency. Latent track registration efficiency is ultimately required to evaluate the radon concentration which consequently determines the effective dose and the radiological hazards. In this research, Monte Carlo simulation experiments were carried out to study the alpha latent track registration efficiency for box type radon dosimeter as a function of dosimeter's dimensions and range of alpha particles in air. Two different self developed Monte Carlo simulation techniques were employed namely: (a) Surface ratio (SURA) method and (b) Ray hitting (RAHI) method. Monte Carlo simulation experiments revealed that there are two types of efficiencies i.e. intrinsic efficiency (ηint) and alpha hit efficiency (ηhit). The ηint depends upon only on the dimensions of the dosimeter and ηhit depends both upon dimensions of the dosimeter and range of the alpha particles. The total latent track registration efficiency is the product of both intrinsic and hit efficiencies. It has been concluded that if diagonal length of box type dosimeter is kept smaller than the range of alpha particle then hit efficiency is achieved as 100%. Nevertheless the intrinsic efficiency keeps playing its role. The Monte Carlo simulation experimental results have been found helpful to understand the intricate track registration mechanisms in the box type dosimeter. This paper explains that how radon concentration from the

  7. Monte Carlo simulation experiments on box-type radon dosimeter

    Energy Technology Data Exchange (ETDEWEB)

    Jamil, Khalid, E-mail: kjamil@comsats.edu.pk; Kamran, Muhammad; Illahi, Ahsan; Manzoor, Shahid

    2014-11-11

    Epidemiological studies show that inhalation of radon gas ({sup 222}Rn) may be carcinogenic especially to mine workers, people living in closed indoor energy conserved environments and underground dwellers. It is, therefore, of paramount importance to measure the {sup 222}Rn concentrations (Bq/m{sup 3}) in indoors environments. For this purpose, box-type passive radon dosimeters employing ion track detector like CR-39 are widely used. Fraction of the number of radon alphas emitted in the volume of the box type dosimeter resulting in latent track formation on CR-39 is the latent track registration efficiency. Latent track registration efficiency is ultimately required to evaluate the radon concentration which consequently determines the effective dose and the radiological hazards. In this research, Monte Carlo simulation experiments were carried out to study the alpha latent track registration efficiency for box type radon dosimeter as a function of dosimeter’s dimensions and range of alpha particles in air. Two different self developed Monte Carlo simulation techniques were employed namely: (a) Surface ratio (SURA) method and (b) Ray hitting (RAHI) method. Monte Carlo simulation experiments revealed that there are two types of efficiencies i.e. intrinsic efficiency (η{sub int}) and alpha hit efficiency (η{sub hit}). The η{sub int} depends upon only on the dimensions of the dosimeter and η{sub hit} depends both upon dimensions of the dosimeter and range of the alpha particles. The total latent track registration efficiency is the product of both intrinsic and hit efficiencies. It has been concluded that if diagonal length of box type dosimeter is kept smaller than the range of alpha particle then hit efficiency is achieved as 100%. Nevertheless the intrinsic efficiency keeps playing its role. The Monte Carlo simulation experimental results have been found helpful to understand the intricate track registration mechanisms in the box type dosimeter. This paper

  8. Sand box experiments with bioclogging of porous media: Hydraulic conductivity reductions

    DEFF Research Database (Denmark)

    Seifert, Dorte; Engesgaard, Peter

    Tracer experiments during clogging and de-clogging experiments in a 2D sand box were via an image analysis used to establish a data set on the relation between changes in hydraulic conductivity (K) and relative porosity (β). Clogging appears to create a finger-like tracer transport, which could be......) that makes no assumption on biomass distribution, the plug formation model of Thullner et al. (2002a), and the biofilm-plug formation model of Vandevivere (1995). The plug formation and biofilm-plug formation models both match the observed changes between the hydraulic conductivity of the sand box and...

  9. Energy use of set-top boxes and telephony products in the U.S.; FINAL

    International Nuclear Information System (INIS)

    The goal of this investigation was to estimate the 1999 energy consumption of set-top boxes and telephony products in the U.S. residential sector. Results of this study will be used to identify new energy conservation opportunities and to align programs with those opportunities. We conducted a bottom-up analysis for set-top boxes and telephony products using our own power measurements and stock and usage estimates from secondary sources. The most common set-top boxes in U.S. homes in 1999 were analog cable boxes, digital cable boxes, wireless receivers, and game consoles. According to these measurements, analog cable boxes and wireless receivers draw between 10 and 15 watts, while digital cable boxes draw between 20 and 25 watts in both the Active and Standby modes. Video games used less than 2 watts in Standby mode, and about 8 watts when Active. We estimate that set-top boxes accounted for 0.7% of residential electricity use in 1999. Our investigation of telephony products included answering machines, cordless phones, cordless phone answering machine combination units, and mobile phone chargers. Answering machines, cordless phones, and combination units use between 2 and 3 watts in both the Active and Standby modes. Mobile phone chargers use about 1 watt in standby. We estimate that these telephony products account for 0.5% of U.S. residential electricity consumption. Together, set-tops and telephony constituted 1.2% of U.S. residential electricity consumption in 1999. Standby power use accounted for about 60% of this energy use. The combined total energy use of the products investigated for this study and those researched previously for this series of reports account for about 6.6% of residential electricity use in the U.S

  10. Energy use of set-top boxes and telephony products in the U.S.

    Energy Technology Data Exchange (ETDEWEB)

    Rosen, Karen B.; Meier, Alan K.; Zandelin, Stefan

    2001-06-01

    The goal of this investigation was to estimate the 1999 energy consumption of set-top boxes and telephony products in the U.S. residential sector. Results of this study will be used to identify new energy conservation opportunities and to align programs with those opportunities. We conducted a bottom-up analysis for set-top boxes and telephony products using our own power measurements and stock and usage estimates from secondary sources. The most common set-top boxes in U.S. homes in 1999 were analog cable boxes, digital cable boxes, wireless receivers, and game consoles. According to these measurements, analog cable boxes and wireless receivers draw between 10 and 15 watts, while digital cable boxes draw between 20 and 25 watts in both the Active and Standby modes. Video games used less than 2 watts in Standby mode, and about 8 watts when Active. We estimate that set-top boxes accounted for 0.7% of residential electricity use in 1999. Our investigation of telephony products included answering machines, cordless phones, cordless phone answering machine combination units, and mobile phone chargers. Answering machines, cordless phones, and combination units use between 2 and 3 watts in both the Active and Standby modes. Mobile phone chargers use about 1 watt in standby. We estimate that these telephony products account for 0.5% of U.S. residential electricity consumption. Together, set-tops and telephony constituted 1.2% of U.S. residential electricity consumption in 1999. Standby power use accounted for about 60% of this energy use. The combined total energy use of the products investigated for this study and those researched previously for this series of reports account for about 6.6% of residential electricity use in the U.S.

  11. Characteristics of wind power on Savonius rotor using a guide-box tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Irabu, Kunio; Roy, Jitendro Nath [Faculty of Mechanical Engineering, University of the Ryukyus, Senbaru-1, Nishihara, Okinawa 903-0213 (Japan)

    2007-11-15

    This study investigates to improve and adjust the output power of Savonius rotor under various wind power and suggests the method of prevention the rotor from strong wind disaster. In this study, as the appropriate device to achieve the purpose of it, a guide-box tunnel is employed. The guide-box tunnel is like a rectangular box as wind passage in which a test rotor is included. The area ratio between the inlet and exit of it is variable to adjust the inlet mass flow rate or input power. At first, the experiment was conducted to find the adequate configuration which would provide the best relative performance. The present experiment, however, does not include the test to retain the guide-box tunnel from the strong wind. The experiments include the static torque test of the fixed rotor at any phase angle and the dynamic torque test at rotation of them. Consequently, it was found that the maximum rotor rotational speed was achieved in the range of the guide-box area ratio between 0.3 and 0.7 and the value of the output power coefficient of the rotor with guide-box tunnel of the area ratio 0.43 increases about 1.5 times with three blades and 1.23 times with two blades greater than that without guide-box tunnel, respectively. It seemed that the performance of Savonius rotor within the guide-box tunnel is comparable enough with other methods for augmentation and control of the output. (author)

  12. 3D modelling of the flow of self-compacting concrete with or without steel fibres. Part II: L-box test and the assessment of fibre reorientation during the flow

    Science.gov (United States)

    Deeb, R.; Kulasegaram, S.; Karihaloo, B. L.

    2014-12-01

    The three-dimensional Lagrangian particle-based smooth particle hydrodynamics method described in Part I of this two-part paper is used to simulate the flow of self-compacting concrete (SCC) with and without steel fibres in the L-box configuration. As in Part I, the simulation of the SCC mixes without fibres emphasises the distribution of large aggregate particles of different sizes throughout the flow, whereas the simulation of high strength SCC mixes which contain steel fibres is focused on the distribution of fibres and their orientation during the flow. The capabilities of this methodology are validated by comparing the simulation results with the L-box test carried out in the laboratory. A simple method is developed to assess the reorientation and distribution of short steel fibres in self-compacting concrete mixes during the flow. The reorientation of the fibres during the flow is used to estimate the fibre orientation factor (FOF) in a cross section perpendicular to the principal direction of flow. This estimation procedure involves the number of fibres cut by the section and their inclination to the cutting plane. This is useful to determine the FOF in practical image analysis on cut sections.

  13. Classificati,Expression Patter,and E3 Ligase Activity Assay of Rice U-Box-Containing Proteins

    Institute of Scientific and Technical Information of China (English)

    Li-Rong Zeng; Chan Ho Park; R.C.Venu; Julian Gough; Guo-Liang Wang

    2008-01-01

    Ubiquitin ligases play a central role in determining the specificity of the ubiquitination system by selecting a myriad of appropriate candidate proteins for modification.The U-box is a recently identified,ubiquitin ligase activityrelated protein domain that shows greater presence in plants than in other organisms.In this study,we identified 77 putative U-box proteins from the rice genome using a battery of whole genome analysis algorithms.Most of the U-box protein genes are expressed,as supported by the identification of their corresponding expressed sequence tags (ESTs),full-length cDNAs,or massively parallel signature sequencing(MPSS)tags.Using the same algorithms,we identified 61 U-box proteins from the Arabidopsis genome.The rice and Arabidopsis U-box proteins were classified into nine major classes based on their domain compositions.Comparison between rice and Arabidopsis U-box proteins indicates that the majority of rice and Arabidopsis U-box proteins have the same domain organizations.The inferred phylogeny established the homology between rice and Arabidopsis U-box/ARM proteins.Cell death assay using the rice protoplast system suggests that one rice U-box gene,OsPU851,might act as a negative regulator of cell death signaling.In addition,the selected U-box proteins were found to be functional E3 ubiquitin ligases.The identification and analysis of rice U-box proteins hereby at the genomic level will help functionally characterize this class of E3 ubiquitin ligase in the future.

  14. The influence of polarization on box air mass factors for UV/vis nadir satellite observations

    Science.gov (United States)

    Hilboll, Andreas; Richter, Andreas; Rozanov, Vladimir V.; Burrows, John P.

    2015-04-01

    Tropospheric abundances of pollutant trace gases like, e.g., NO2, are often derived by applying the differential optical absorption spectroscopy (DOAS) method to space-borne measurements of back-scattered and reflected solar radiation. The resulting quantity, the slant column density (SCD), subsequently has to be converted to more easily interpretable vertical column densities by means of the so-called box air mass factor (BAMF). The BAMF describes the ratio of SCD and VCD within one atmospheric layer and is calculated by a radiative transfer model. Current operational and scientific data products of satellite-derived trace gas VCDs do not include the effect of polarization in their radiative transfer models. However, the various scattering processes in the atmosphere do lead to a distinctive polarization pattern of the observed Earthshine spectra. This study investigates the influence of these polarization patterns on box air mass factors for satellite nadir DOAS measurements of NO2 in the UV/vis wavelength region. NO2 BAMFs have been simulated for a multitude of viewing geometries, surface albedos, and surface altitudes, using the radiative transfer model SCIATRAN. The results show a potentially large influence of polarization on the BAMF, which can reach 10% and more close to the surface. A simple correction for this effect seems not to be feasible, as it strongly depends on the specific measurement scenario and can lead to both high and low biases of the resulting NO2 VCD. We therefore conclude that all data products of NO2 VCDs derived from space-borne DOAS measurements should include polarization effects in their radiative transfer model calculations, or at least include the errors introduced by using linear models in their uncertainty estimates.

  15. 49 CFR 230.103 - Tender roller bearing journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender roller bearing journal boxes. 230.103... Locomotives and Tenders Running Gear § 230.103 Tender roller bearing journal boxes. Tender roller bearing journal boxes shall be maintained in a safe and suitable condition....

  16. 49 CFR 230.102 - Tender plain bearing journal boxes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Tender plain bearing journal boxes. 230.102... Locomotives and Tenders Running Gear § 230.102 Tender plain bearing journal boxes. Plain bearing journal boxes... expected to damage the bearing; or have a detrimental effect on the lubrication of the journal and...

  17. Application of Defense Technology Commonly Used in Boxing Match

    Institute of Scientific and Technical Information of China (English)

    Zhixiao Li[1; Jianjun Liu[2

    2015-01-01

    Boxing defense technology is a kind of techniques to prevent the opponent from attacking successfully. Boxing is a kind of sports that needs close cooperation between attack and defense. Attack is used for defense, where there is no attack, there will be no defense, and vice versa. Defense technology is the foundation of attack technology, therefore, defense is of vital importance in boxing match.

  18. Majorana Fermions in a Box

    CERN Document Server

    Al-Hashimi, M H; Wiese, U -J

    2016-01-01

    Majorana fermion dynamics may arise at the edge of Kitaev wires or superconductors. Alternatively, it can be engineered by using trapped ions or ultracold atoms in an optical lattice as quantum simulators. This motivates the theoretical study of Majorana fermions confined to a finite volume, whose boundary conditions are characterized by self-adjoint extension parameters. While the boundary conditions for Dirac fermions in $(1+1)$-d are characterized by a 1-parameter family, $\\lambda = - \\lambda^*$, of self-adjoint extensions, for Majorana fermions $\\lambda$ is restricted to $\\pm i$. Based on this result, we compute the frequency spectrum of Majorana fermions confined to a 1-d interval. The boundary conditions for Dirac fermions confined to a 3-d region of space are characterized by a 4-parameter family of self-adjoint extensions, which is reduced to two distinct 1-parameter families for Majorana fermions. We also consider the problems related to the quantum mechanical interpretation of the Majorana equation ...

  19. Pathology of aural abscesses in free-living Eastern box turtles (Terrapene carolina carolina).

    Science.gov (United States)

    Brown, Justin D; Richards, Jean M; Robertson, John; Holladay, Steven; Sleeman, Jonathan M

    2004-10-01

    Aural abscess or abscess of the middle ear is common in free-living Eastern box turtles (Terrapene carolina carolina) of Virginia (USA) and elsewhere. Although its etiology remains unknown, hypovitaminosis A has been suggested on the basis of similar lesions occurring in captive chelonians fed diets that are deficient in vitamin A. This hypothesis was supported by significantly greater body burdens of organochlorine compounds (reported disruptors of vitamin A metabolism) and a nonsignificant trend toward lower serum and hepatic vitamin A levels in free-living box turtles with this lesion. The tympanic epithelium was evaluated in 27 box turtles (10 with aural abscesses and 17 without). Lesions of the tympanic epithelium of box turtles with aural abscesses included hyperplasia, squamous metaplasia, hyperemia, cellular sloughing, granulomatous inflammation, and bacterial infection. These changes were more severe in turtles with aural abscesses than in those without and were more severe in tympanic cavities that had an abscess compared to those without when the lesion was unilateral. Organs from 21 box turtles (10 with aural abscesses and 11 without) from the study population were examined for microscopic lesions, and minimal histopathologic changes were found, none of which were similar to those found in the tympanic epithelium. Histopathologic changes in box turtles with aural abscesses were consistent with a syndrome that may involve hypovitaminosis A. PMID:15650088

  20. Launch Pad in a Box

    Science.gov (United States)

    Mantovani, J. G.; Tamasy, G. J.; Mueller, R. P.; Townsend, I. I.; Sampson, J. W.; Lane, M. A.

    2016-01-01

    NASA Kennedy Space Center (KSC) is developing a new deployable launch system capability to support a small class of launch vehicles for NASA and commercial space companies to test and launch their vehicles. The deployable launch pad concept was first demonstrated on a smaller scale at KSC in 2012 in support of NASA Johnson Space Center's Morpheus Lander Project. The main objective of the Morpheus Project was to test a prototype planetary lander as a vertical takeoff and landing test-bed for advanced spacecraft technologies using a hazard field that KSC had constructed at the Shuttle Landing Facility (SLF). A steel pad for launch or landing was constructed using a modular design that allowed it to be reconfigurable and expandable. A steel flame trench was designed as an optional module that could be easily inserted in place of any modular steel plate component. The concept of a transportable modular launch and landing pad may also be applicable to planetary surfaces where the effects of rocket exhaust plume on surface regolith is problematic for hardware on the surface that may either be damaged by direct impact of high speed dust particles, or impaired by the accumulation of dust (e.g., solar array panels and thermal radiators). During the Morpheus free flight campaign in 2013-14, KSC performed two studies related to rocket plume effects. One study compared four different thermal ablatives that were applied to the interior of a steel flame trench that KSC had designed and built. The second study monitored the erosion of a concrete landing pad following each landing of the Morpheus vehicle on the same pad located in the hazard field. All surfaces of a portable flame trench that could be directly exposed to hot gas during launch of the Morpheus vehicle were coated with four types of ablatives. All ablative products had been tested by NASA KSC and/or the manufacturer. The ablative thicknesses were measured periodically following the twelve Morpheus free flight tests