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Sample records for bone joint surg

  1. Roentgenological semiotics of bone and bone joints pathology

    International Nuclear Information System (INIS)

    Zedgenidze, G.A.; Kishkovskij, A.N.; Elashov, Yu.G.

    1984-01-01

    Physiologic and pathologic processes in bones followed by alternations of bone structure and reflected on roentgenograms are considered and described. Most frequent reasons for roentgenodiagnosis errors in diseases of bone and bone joint apparatus are presented

  2. Bone marrow edema of the knee joint

    International Nuclear Information System (INIS)

    Breitenseher, M.J.; Mayerhoefer, M.E.; Hofmann, S.

    2006-01-01

    Bone marrow edema of the knee joint is a frequent clinical picture in MR diagnostics. It can be accompanied by symptoms and pain in the joint. Diseases that are associated with bone marrow edema can be classified into different groups. Group 1 includes vascular ischemic bone marrow edema with osteonecrosis (synonyms: SONK or Ahlbaeck's disease), osteochondrosis dissecans, and bone marrow edema syndrome. Group 2 comprises traumatic or mechanical bone marrow edema. Group 3 encompasses reactive bone marrow edemas such as those occurring in gonarthrosis, postoperative bone marrow edemas, and reactive edemas in tumors or tumorlike diseases. Evidence for bone marrow edema is effectively provided by MRI, but purely morphological MR information is often unspecific so that anamnestic and clinical details are necessary in most cases for definitive disease classification. (orig.) [de

  3. Joint projections of sea level and storm surge using a flood index

    Science.gov (United States)

    Little, C. M.; Lin, N.; Horton, R. M.; Kopp, R. E.; Oppenheimer, M.

    2016-02-01

    Capturing the joint influence of sea level rise (SLR) and tropical cyclones (TCs) on future coastal flood risk poses significant challenges. To address these difficulties, Little et al. (2015) use a proxy of tropical cyclone activity and a probabilistic flood index that aggregates flood height and duration over a wide area (the US East and Gulf coasts). This technique illuminates the individual impacts of TCs and SLR and their correlation across different coupled climate models. By 2080-2099, changes in the flood index relative to 1986-2005 are substantial and positively skewed: a 10th-90th percentile range of 35-350x higher for a high-end business-as-usual emissions scenario (see figure). This aggregated flood index: 1) is a means to consistently combine TC-driven storm surges and SLR; 2) provides a more robust description of historical surge-climate relationships than is available at any one location; and 3) allows the incorporation of a larger climate model ensemble - which is critical to uncertainty characterization. It does not provide a local view of the complete spectrum of flood severity (i.e. return curves). However, alternate techniques that provide localized return curves (e.g. Lin et al., 2012) are computationally intensive, limiting the set of large-scale climate models that can be incorporated, and require several linked statistical and dynamical models, each with structural uncertainties that are difficult to quantify. Here, we present the results of Little et al. (2015) along with: 1) alternate formulations of the flood index; 2) strategies to localize the flood index; and 3) a comparison of flood index projections to those provided by model-based return curves. We look to this interdisciplinary audience for feedback on the advantages and disadvantages of each tool for coastal planning and decision-making. Lin, N., K. Emanuel, M. Oppenheimer, and E. Vanmarcke, 2012: Physically based assessment of hurricane surge threat under climate change. Nature

  4. New aspects of radionuclide therapy of bone and joint diseases

    International Nuclear Information System (INIS)

    Fischer, M.

    2001-01-01

    Whereas in developing countries P-32 is widely used for radionuclide therapy of painful bone metastases, in Europe three radionuclides or radiopharmaceutical agents are available for pain palliation: Sr-89, Sm-153-EDTMP, and Re-186-HEDP. Radionuclide therapy for pain palliation is indicated for bone pain due to metastatic malignancy that has involved multiple skeletal sites and has evoked an osteoblastic response on bone scintigraphy. Response rates of about 70-80% in patients with breast or prostate cancer is reported in the literature, less in metastatic lesions of other primary malignancies. Sm-153-EDTMP may also be used for curative treatment of primary bone tumours or their metastases. Radiosynovectomy as therapeutic procedure or rheumatoid arthritis, other inflammatory joint diseases, persistent synovial perfusion, and other joint diseases is widely used. Using Y-90 for the knee joint, Re-186 for middle sized joints, and Er-169 for small joints an improvement of symptoms may be observed in about 70-80%. (author)

  5. Utility of bone SPECT in temporomandibular joint pain

    International Nuclear Information System (INIS)

    Yang, Dong Hunn; Sung, Mi Sook; Lee, Jung Whee; Chung, Soo Kyo; Shinn, Kyung Sub

    1997-01-01

    Temporomandibular (TM) joint pain results from many etiologic factors. The aim of this study was to evaluate the utility of Bone SPECT in patients with TM joint pain. The subjects were 34 patients with TM joint pain. All patients underwent plain radiography, planar bone scan, and Bone SPECT. The intensity of radioisotope uptake at TM joint was graded into three; no increased uptake above the background activity as grade 0, uptake similar to occipital bone as grade I, and uptake similar to maxillary sinus as grade II. Clinical findings and therapeutic methods were reviewed. Twenty-seven patients (80%) out of 34 patients with TM joint pain had increased uptake in bone SPECT. Twenty-one (78%) out of 27 patients had increased uptake in the mandibular condyle and remaining six patients (22%) had uptake in the mandibular and maxillary arch, which proved to be dental problem. Seven patients (21%) out of 34 were grade as 0, four (12%) were grade I, 23 (68%) were grade. II. Four patients with grade I had clicking sound and symptoms which were subsided with medication in all cases. Among 23 patients with grade II, 7 patients had clicking sound and 14 patients underwent medication and decompression therapy. With Planar bone scan, 11 cases (32%) had increased uptake in TM joint area. Plain radiography revealed narrowing, distension, erosion and limitation of TM joint in 16 cases (47%). Bone SPECT can be valuable for screening and managing the patients with TM joint pain. Patients with grade II needed intensive treatment such as joint aspiration. However degree of the radioisotope uptake did not well correlated with clinical symptoms

  6. Bone and Joint Problems Associated with Diabetes

    Science.gov (United States)

    ... bone metabolism (diabetic osteodystrophy): Time for recognition. Osteoporosis International. 2016;27:1931. Hull B, et al. Diabetes and bone. The American Journal of the Medical Sciences. 2016;351:356. What people with diabetes need ...

  7. Does aspiration of bones and joints affect results of later bone scanning

    International Nuclear Information System (INIS)

    Canale, S.T.; Harkness, R.M.; Thomas, P.A.; Massie, J.D.

    1985-01-01

    To determine the effect, if any, of needle aspiration on /sup 99m/Tc bone scanning, three different areas of 15 dogs were first aspirated and then imaged with technetium bone scintigraphy. The hip joint was aspirated, the distal femoral metaphysis was drilled and aspirated, and the tibial periosteum was scraped with an 18- or 20-gauge needle. Varying amounts of trauma were inflicted to simulate varying difficulties at aspiration. /sup 99m/Tc bone scans were obtained from 5 h to 10 days later. There was no evidence of focal technetium uptake after any hip joint aspiration. This was consistent regardless of the amount of trauma inflicted or the time from aspiration to bone scanning. Metaphyseal cortical drilling and tibial periosteal scraping occasionally caused some focal uptake when scanning was delayed greater than 2 days. When osteomyelitis or pyarthrosis is clinically suspected, joint aspiration can be performed without fear of producing a false- positive bone scan

  8. Joint cartilage thickness and automated determination of bone age and bone health in juvenile idiopathic arthritis.

    Science.gov (United States)

    Twilt, Marinka; Pradsgaard, Dan; Spannow, Anne Helene; Horlyck, Arne; Heuck, Carsten; Herlin, Troels

    2017-08-10

    BoneXpert is an automated method to calculate bone maturation and bone health index (BHI) in children with juvenile idiopathic arthritis (JIA). Cartilage thickness can also be seen as an indicator for bone health and arthritis damage. The objective of this study was to evaluate the relation between cartilage thickness, bone maturation and bone health in patients with JIA. Patients with JIA diagnosed according ILAR criteria included in a previous ultrasonography (US) study were eligible if hand radiographs were taken at the same time as the US examination. Of the 95 patients 67 met the inclusion criteria. Decreased cartilage thickness was seen in 27% of the examined joints. Decreased BHI was seen in half of the JIA patient, and delayed bone maturation was seen in 33% of patients. A combination of decreased BHI and bone age was seen in 1 out of 5 JIA patients. Decreased cartilage thickness in the knee, wrist and MCP joint was negatively correlated with delayed bone maturation but not with bone health index. Delayed bone maturation and decreased BHI were not related to a thinner cartilage, but a thicker cartilage. No relation with JADAS 10 was found. The rheumatologist should remain aware of delayed bone maturation and BHI in JIA patients with cartilage changes, even in the biologic era.

  9. Preceding trauma in childhood hematogenous bone and joint infections.

    Science.gov (United States)

    Pääkkönen, Markus; Kallio, Markku J T; Lankinen, Petteri; Peltola, Heikki; Kallio, Pentti E

    2014-03-01

    Preceding trauma may play a role in the etiology and pathogenesis of hematogenous bone and joint infections. Among 345 children with an acute hematogenous bone and/or joint infection, 20% reported trauma during a 2-week period leading to infection. Blunt impact, bruises, or excoriations were commonly reported. The rate was similar to that in the general pediatric population obtained from the literature. In the study group, patients with and without trauma were similar in age, serum C-reactive protein and erythrocyte sedimentation rate, length of hospitalization, and late sequelae. Preceding minor trauma did not prove to be significant as an etiological or as a prognostic factor.

  10. Transarticular invasion of bone tumours across the sacroiliac joint

    International Nuclear Information System (INIS)

    Chhaya, S.; White, L.M.; Kandel, R.; Wunder, J.S.; Ferguson, P.; Agur, A.

    2005-01-01

    The purpose of this study was to evaluate the pattern of tumour spread across the SI articulation, correlating with cadaveric anatomic observations, in order to better understand the local spread of tumour and to assist in the assessment of local staging. Twenty-four consecutive patients (14 male, 10 female; age range 22-89 years, mean 52 years) with primary bone tumours of the iliac bone or sacrum abutting the SI joint, in whom surgical resection of the SI joint was performed, were studied following institutional ethics approval. In all patients, preoperative magnetic resonance (MR) imaging studies of the pelvis and SI joint were reviewed for imaging evidence of transarticular extension across the SI joint. Gross pathologic and histologic assessment of possible transarticular SI joint tumour extension was performed in all patients. Nine cadaveric pelvic specimens without pelvic neoplastic disease (4 male, 5 female; age range 20-84 years, mean 59 years, median 58 years) were anatomically dissected and the articular anatomy of the SI joint examined macroscopically. Twelve of the twenty-four patients demonstrated imaging and histological evidence of transarticular SI joint invasion. Eight tumours infiltrated only the interosseous ligamentous aspect of the SI joint. In the remaining four cases, extensive tumour infiltrated both the cartilaginous and ligamentous aspects of the joint. No case showed tumour involvement isolated to the cartilaginous aspect of the joint. Among the cadaveric specimens studied, degenerative changes were found involving the majority of cases (6/9), with cartilage thinning and fibrillation and antero-superior marginal osteophytes seen involving the cartilaginous portion of the SI joint articulation. Four of the nine specimens demonstrated central ossification bridging the iliac and sacral aspects of the ligamentous (interosseous) SI joint. (orig.)

  11. Transarticular invasion of bone tumours across the sacroiliac joint

    Energy Technology Data Exchange (ETDEWEB)

    Chhaya, S. [University of Toronto, Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, Toronto (Canada); University of Texas Health Science Centre, Department of Radiology, San Antonio, TX (United States); White, L.M. [University of Toronto, Department of Medical Imaging, Mount Sinai Hospital and the University Health Network, Toronto (Canada); Kandel, R. [University of Toronto, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto (Canada); Wunder, J.S.; Ferguson, P. [Univeristy of Toronto, University Musculoskeletal Oncology Unit, Department of Orthopedic Surgery, Mount Sinai Hospital, Toronto (Canada); Agur, A. [University of Toronto, Division of Anatomy, Department of Surgery, Toronto (Canada)

    2005-12-01

    The purpose of this study was to evaluate the pattern of tumour spread across the SI articulation, correlating with cadaveric anatomic observations, in order to better understand the local spread of tumour and to assist in the assessment of local staging. Twenty-four consecutive patients (14 male, 10 female; age range 22-89 years, mean 52 years) with primary bone tumours of the iliac bone or sacrum abutting the SI joint, in whom surgical resection of the SI joint was performed, were studied following institutional ethics approval. In all patients, preoperative magnetic resonance (MR) imaging studies of the pelvis and SI joint were reviewed for imaging evidence of transarticular extension across the SI joint. Gross pathologic and histologic assessment of possible transarticular SI joint tumour extension was performed in all patients. Nine cadaveric pelvic specimens without pelvic neoplastic disease (4 male, 5 female; age range 20-84 years, mean 59 years, median 58 years) were anatomically dissected and the articular anatomy of the SI joint examined macroscopically. Twelve of the twenty-four patients demonstrated imaging and histological evidence of transarticular SI joint invasion. Eight tumours infiltrated only the interosseous ligamentous aspect of the SI joint. In the remaining four cases, extensive tumour infiltrated both the cartilaginous and ligamentous aspects of the joint. No case showed tumour involvement isolated to the cartilaginous aspect of the joint. Among the cadaveric specimens studied, degenerative changes were found involving the majority of cases (6/9), with cartilage thinning and fibrillation and antero-superior marginal osteophytes seen involving the cartilaginous portion of the SI joint articulation. Four of the nine specimens demonstrated central ossification bridging the iliac and sacral aspects of the ligamentous (interosseous) SI joint. (orig.)

  12. Joint cartilage thickness and automated determination of bone age and bone health in juvenile idiopathic arthritis

    DEFF Research Database (Denmark)

    Twilt, Marinka; Pradsgaard, Dan; Spannow, Anne Helene

    2017-01-01

    BACKGROUND: BoneXpert is an automated method to calculate bone maturation and bone health index (BHI) in children with juvenile idiopathic arthritis (JIA). Cartilage thickness can also be seen as an indicator for bone health and arthritis damage. The objective of this study was to evaluate...... the relation between cartilage thickness, bone maturation and bone health in patients with JIA. METHODS: Patients with JIA diagnosed according ILAR criteria included in a previous ultrasonography (US) study were eligible if hand radiographs were taken at the same time as the US examination. Of the 95 patients...... 67 met the inclusion criteria. RESULTS: Decreased cartilage thickness was seen in 27% of the examined joints. Decreased BHI was seen in half of the JIA patient, and delayed bone maturation was seen in 33% of patients. A combination of decreased BHI and bone age was seen in 1 out of 5 JIA patients...

  13. Bones, Muscles, and Joints: The Musculoskeletal System

    Science.gov (United States)

    ... stabilize it while the bone heals. Muscular dystrophy . Muscular dystrophy is an inherited group of diseases that affect the muscles, causing them to weaken and break down over time. The most common form in childhood is called Duchenne muscular dystrophy, and it most often affects boys. ...

  14. Nano-material aspects of shock absorption in bone joints.

    Science.gov (United States)

    Tributsch, H; Copf, F; Copf, P; Hindenlang, U; Niethard, F U; Schneider, R

    2010-01-01

    This theoretical study is based on a nano-technological evaluation of the effect of pressure on the composite bone fine structure. It turned out, that the well known macroscopic mechano-elastic performance of bones in combination with muscles and tendons is just one functional aspect which is critically supported by additional micro- and nano- shock damping technology aimed at minimising local bone material damage within the joints and supporting spongy bone material. The identified mechanisms comprise essentially three phenomena localised within the three-dimensional spongy structure with channels and so called perforated flexible tensulae membranes of different dimensions intersecting and linking them. Kinetic energy of a mechanical shock may be dissipated within the solid-liquid composite bone structure into heat via the generation of quasi-chaotic hydromechanic micro-turbulence. It may generate electro-kinetic energy in terms of electric currents and potentials. And the resulting specific structural and surface electrochemical changes may induce the compressible intra-osseal liquid to build up pressure dependent free chemical energy. Innovative bone joint prostheses will have to consider and to be adapted to the nano-material aspects of shock absorption in the operated bones.

  15. Haematogenous pyogenic bone and joint sepsis – reducing ...

    African Journals Online (AJOL)

    Background and objectives. Delayed presentation of haematogenous bone and joint sepsis is common in our childhood population and leads to a large burden of avoidable morbidity extending into adult life. We set out to determine causative factors in these delays. Design. A prospective study was undertaken over a 1- ...

  16. Bone demarcation of the temporomandibular joint. Validity of clinical assessment of bone thickness by means of CT

    International Nuclear Information System (INIS)

    Ahlqvist, J.B.; Isberg, A.M.

    1998-01-01

    Purpose: To study the CT depiction of bone demarcations in the temporomandibular joint, using conventional window level and window width; and to evaluate observer performance in estimating bone thickness in these images. Material and Methods: Seven joint specimens were imaged by CT and then cryosectioned. The measurements of bone wall thickness in the images were compared to the true bone thickness at each cutting level. In addition, 4 experienced radiologists estimated the thickness of the bone walls in the images. Results: The relative difference between the CT reproduction and the true bone thickness was small for bone walls thicker than 2 mm. This difference increased with the decrease in bone thickness and the increase in the inclination of the bone wall from the perpendicular to the image plane. Bone walls thinner than 1 mm were reproduced as considerably thicker than their true thickness. This resulted in a clinical overestimation of bone thickness. Conclusion: Both the CT representation and the interpretation of bone demarcation in the temporomandibular joint may constitute a problem. Partial volume averaging effects can result in an overestimation of bone dimensions amounting to 200% for thin bones. The central white zone in images of thin bone walls obtained with the parameters described here could serve as an indicator that could help to reduce the risk of overestimating bone thickness. (orig.)

  17. [Allogeneic vascularized transplantation in cases of bone and joint defects].

    Science.gov (United States)

    Hofmann, G O; Kirschner, M H; Gonschorek, O; Bühren, V

    1999-06-01

    This paper presents preliminary results of allogeneic vascularized transplantations of three femoral diaphyses and four total human knee joints. Grafts were harvested from multi-organ-donors and immediately transplanted. Osteosyntheses were performed employing intramedullary nails. Vascular pedicles of the grafts were anastomosed in end-to-side technique. Immunosuppression mainly based on Cyclosporine and Azathioprine. Grafts' perfusion was demonstrated by DSA and Duplex-sonograms, bone metabolism by SPECT-scintigraphy. Five months following transplantation osteotomies demonstrated consolidation in conventional X-rays. Biopsies of the grafted bone revealed intact osteocytes and arthroscopy demonstrated intact synovial, chondral and ligamentous structures. From the technical aspect vascularized transplantation of the femoral diaphyses and total knee joints is feasible. The main problems are of immunologic nature. Transplantations were performed respecting the ABO-compatibility but with a large HLA-mismatch. Acute and chronic rejection crises may damage the grafts. At least in synovial joints live-long immunosuppression of the recipients seems to be unavoidable.

  18. Bones - joints - soft tissues II. 7. rev. ed.

    International Nuclear Information System (INIS)

    Dihlmann, W.; Frommhold, W.

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs [de

  19. Sacro-iliac joint disease in drug abusers: The role of bone scintigraphy

    International Nuclear Information System (INIS)

    Lopez-Majano, V.; Miskew, D.B.W.; Cook County Hospital, Chicago, IL

    1980-01-01

    Bone scintigrams demonstrated increased uptake in the sacroiliac joint in twenty drug addicts with low back pain and signs of localized sepsis. The localization of the disease was decisive for the orthopedist in the aspiration of the affected joint. (orig.)

  20. Bone and Joint Decade 2000-2010 in Neplease Perspective

    Directory of Open Access Journals (Sweden)

    B P Paudyal

    2010-09-01

    Full Text Available The Bone and Joint Decade is a worldwide multi-disciplinary initiative targeting the care of people with musculoskeletal disorders. It focuses on improving the quality of life of these people through advances in the understanding and treatment through education, research, and prevention strategies. Though the epidemiological data in Nepal are very scanty, worldwide statistics have shown that musculoskeletal conditions represent more than half of all chronic diseases, and are the most common cause of severe long-term pain and disability. There is acute shortage of specialist manpower that care for people with these disorders. Furthermore the teaching in musculoskeletal disorders in health institutions is very minimal. All of these problems highlight the need for expanding the teaching of musculoskeletal disorders at all levels of medical education; promotion of clinical research; improving diagnostic, treatment, and rehabilitative facilities; and implementation of preventive strategies to reduce the burden of these chronic debilitating conditions in the society. Keywords: bone and joint decade, musculoskeletal and rheumatic diseases, Nepal.

  1. A Case Study of Preliminary Cost-Benefit Analysis of Building Levees to Mitigate the Joint Effects of Sea Level Rise and Storm Surge

    Directory of Open Access Journals (Sweden)

    Binbin Peng

    2018-02-01

    Full Text Available Sea-level rise (SLR will magnify the impacts of storm surge; the resulting severe flooding and inundation can cause huge damage to coastal communities. Community leaders are considering implementing adaptation strategies, typically hard engineering projects, to protect coastal assets and resources. It is important to understand the costs and benefits of the proposed project before any decision is made. To mitigate the flooding impact of joint effects of storm surge and SLR, building levee segments is chosen to be a corresponding adaptation strategy to protect the real estate assets in the study area—the City of Miami, FL, USA. This paper uses the classic Cost-Benefit Analysis (CBA to assess the cost efficiency and proposes corresponding improvements in the benefit estimation, by estimating the avoided damages of implementing levee projects. Results show that the city will benefit from implementing levee projects along the Miami River in both a one-time 10 year storm event with SLR and cumulative long-term damage scenarios. This study also suggests that conducting CBA is a critical process before making coastal adaptation planning investment. A more meaningful result of cost effectiveness is estimated by accounting for the appreciation and time value. In addition, a sensitivity analysis is conducted to verify how the choice of discount rate influences the result. Uncertain factors including the rate of SLR, storm intensification, land use changes, and real estate appreciation are further analyzed.

  2. Patient and implant survival following joint replacement because of metastatic bone disease

    DEFF Research Database (Denmark)

    Sørensen, Michala S; Gregersen, Kristine G; Grum-Schwensen, Tomas

    2013-01-01

    Patients suffering from a pathological fracture or painful bony lesion because of metastatic bone disease often benefit from a total joint replacement. However, these are large operations in patients who are often weak. We examined the patient survival and complication rates after total joint...... replacement as the treatment for bone metastasis or hematological diseases of the extremities....

  3. Fracture line index of fibular stalk and the ankle joint bone in the classification of the ankle joint trauma

    International Nuclear Information System (INIS)

    Wu Jun; Zhang Qiang

    2003-01-01

    Objective: To evaluate the fracture line index of fibular stalk and the ankle joint bone in the classification of the ankle joint trauma. Methods: Measure fracture line index of fibular stalk and the ankle joint in 217 adult cases of fracture and dislocation of ankle joint. And the cases were classified by the results of the measurement. Results: Measurement was unavailable in 9 cases of tearing fracture. In 31 cases, the lesions could not be particularly classified. And in the rest 176 cases the trauma were precisely classified. The over all successful rate was 81.6%. Conclusion: Fracture line index of fibular stalk and the ankle joint bone are valuable in classification of the trauma of the angle joint. While the specificity of this method is low in differentiating the adducting and abducting fracture of the medial angle, in which a combined investigation is recommended

  4. Template-based automatic extraction of the joint space of foot bones from CT scan

    Science.gov (United States)

    Park, Eunbi; Kim, Taeho; Park, Jinah

    2016-03-01

    Clean bone segmentation is critical in studying the joint anatomy for measuring the spacing between the bones. However, separation of the coupled bones in CT images is sometimes difficult due to ambiguous gray values coming from the noise and the heterogeneity of bone materials as well as narrowing of the joint space. For fine reconstruction of the individual local boundaries, manual operation is a common practice where the segmentation remains to be a bottleneck. In this paper, we present an automatic method for extracting the joint space by applying graph cut on Markov random field model to the region of interest (ROI) which is identified by a template of 3D bone structures. The template includes encoded articular surface which identifies the tight region of the high-intensity bone boundaries together with the fuzzy joint area of interest. The localized shape information from the template model within the ROI effectively separates the bones nearby. By narrowing the ROI down to the region including two types of tissue, the object extraction problem was reduced to binary segmentation and solved via graph cut. Based on the shape of a joint space marked by the template, the hard constraint was set by the initial seeds which were automatically generated from thresholding and morphological operations. The performance and the robustness of the proposed method are evaluated on 12 volumes of ankle CT data, where each volume includes a set of 4 tarsal bones (calcaneus, talus, navicular and cuboid).

  5. Bone scanning a useful addition in the diagnosis of ankle joint trauma

    International Nuclear Information System (INIS)

    Schmidt, C.

    1983-01-01

    A retrospective study of the indication in 169 scintigraphic examinations of the ankle joint was made. Usually joints respond to trauma with a generalized increase of the concentration of the radiopharmaceutical. By using a highly performed technique the focal hot spot caused by the fracture can be seen in the bone scan. The focal accumulation of the radioactive material must not correspond to a bone fracture in any case. The ligamentous avulsion of a bone chip and/or the periosteum can yield the same image but it cannot be diagnosed by radiographic techniques. Initially the routine radiograph and even the tomograph often are interpreted as normal or equivocal. In these cases of ankle trauma bone scanning completes the clinical evaluation. Although bone scanning is very important in the diagnosis of any traumatic lesion of the ankle joints it cannot replace the conventional X-ray technique. (orig.) [de

  6. Detection of degenerative disease of the temporomandibular joint by bone scintigraphy: concise communication

    International Nuclear Information System (INIS)

    Goldstein, H.A.; Bloom, C.Y.

    1980-01-01

    Nine patients with facial pain were evaluated with limited bone scans. The scintigrams correlated with microscopy in all patients, although radiographs correlated with microscopy in only five patients. The degenerative disease process in the temporomandibular joint was more extensive in the patients with radiographic and scintigraphic abnormalities than in those with scintigraphic abnormalities alone. The limited bone scan appears useful in detecting early degenerative changes in the temporomandibular joint

  7. Transarticular invasion of the sacroiliac joints by malignant pelvic bone tumors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hwang Woo; Huh, Jin Do; Kim, Seong Min; Cho, Young Duk [College of Medicine, Kosin Univ., Pusan (Korea, Republic of); Cho, Kil Ho [College of Medicine, Yeungnam Univ., Daegu (Korea, Republic of)

    2002-03-01

    To describe modes of transarticular invasion, with reference to the size and location of a tumor, the anatomic characteristics of invaded cartilage,and the existence of ankylosis in SI joint. Eleven histologically confirmed malignant pelvic bone tumors involving transarticular invasion of sacroiliac joints, were retrospectively analysed. Transarticular invasion of a joint was defined as involvement of its opposing bones. The anatomic site and size of the tumors were analysed, and invaded sacroiliac joint was divided into upper, middle and lower parts on the basis of the anatomic characteristics of the intervening cartilage: synovial hyaline or fibrous ligamentous. the existence of ankylosis was determined, and transarticular invasion directly across a joint was classified as direct invasion. Extension of tumors around a joint from its periphery to the opposing bone were considered as indirect invasion. All tumors were located near the sacroiliac joint, eight at the ilium and three at the sacrum. Six invasions were indirect and five were direct. Average tumor area was larger in indirect cases than in direct: 191.8 cm{sup 2} vs. 69.6 cm{sup 2}. In all indirect invasions, a huge soft tissue mass abutted onto the peripheral portion of the sacroiliac joint. In five of six cases of indirect transarticular invasion, the upper part of the joint posteriorly located fibrous ligamentous cartilage. In the other, the lower part was invaded, and this involved a detour around the joint space, avoiding the invasion of intervening cartilage. Ankylosis occurred in one of the indirect cases. Among the five cases of direct invasion, there was invasion of the posteriorly located ligamentous fibrous cartilage in three without ankylosis. In the other two cases, involving ankylosis, the synovial hyaline cartilage was invaded directly at the lower part of the joint. Transarticular invasions of sacroiliac joint via fibrous cartilage are most common. Ankylosis of the sacroiliac joint

  8. Transarticular invasion of the sacroiliac joints by malignant pelvic bone tumors

    International Nuclear Information System (INIS)

    Lee, Hwang Woo; Huh, Jin Do; Kim, Seong Min; Cho, Young Duk; Cho, Kil Ho

    2002-01-01

    To describe modes of transarticular invasion, with reference to the size and location of a tumor, the anatomic characteristics of invaded cartilage,and the existence of ankylosis in SI joint. Eleven histologically confirmed malignant pelvic bone tumors involving transarticular invasion of sacroiliac joints, were retrospectively analysed. Transarticular invasion of a joint was defined as involvement of its opposing bones. The anatomic site and size of the tumors were analysed, and invaded sacroiliac joint was divided into upper, middle and lower parts on the basis of the anatomic characteristics of the intervening cartilage: synovial hyaline or fibrous ligamentous. the existence of ankylosis was determined, and transarticular invasion directly across a joint was classified as direct invasion. Extension of tumors around a joint from its periphery to the opposing bone were considered as indirect invasion. All tumors were located near the sacroiliac joint, eight at the ilium and three at the sacrum. Six invasions were indirect and five were direct. Average tumor area was larger in indirect cases than in direct: 191.8 cm 2 vs. 69.6 cm 2 . In all indirect invasions, a huge soft tissue mass abutted onto the peripheral portion of the sacroiliac joint. In five of six cases of indirect transarticular invasion, the upper part of the joint posteriorly located fibrous ligamentous cartilage. In the other, the lower part was invaded, and this involved a detour around the joint space, avoiding the invasion of intervening cartilage. Ankylosis occurred in one of the indirect cases. Among the five cases of direct invasion, there was invasion of the posteriorly located ligamentous fibrous cartilage in three without ankylosis. In the other two cases, involving ankylosis, the synovial hyaline cartilage was invaded directly at the lower part of the joint. Transarticular invasions of sacroiliac joint via fibrous cartilage are most common. Ankylosis of the sacroiliac joint facilitates

  9. Bone scan and joint scan of hands and feet in rheumatoid arthritis

    International Nuclear Information System (INIS)

    Carpentier, N.; Verbeke, S.; Perdrisot, R.; Grilo, R.M.; Quenesson, E.; Bonnet, C.; Vergne, P.; Treves, R.; Bertin, P.; Boutros-Toni, F.

    2000-01-01

    The aim of this study was to determine the ability of joint scan and bone scan of hands and feet, in patients with rheumatoid arthritis, to localize the altered joints. The sensitivity, the specificity, the positive predictive value (PPV) and the negative predictive value (NPV) of joint scan were determined in comparison with clinical joint assessment. Fifteen patients (780 joints) were clinically examined (pain and synovitis); during the same day, a bone scan and a joint scan were realized by oxidronate 99m Tc intravenous injection. Patients were scanned 5 minutes (tissual time, T t ) and 3 hours 1/4 (bone time, T 0 ) after the administration. The uptake of the bi-phosphonate was evaluated with a qualitative method using a grey scale. The uptake of 99m Tc oxidronate was quantitated using an extra-articular region of interest. The sensitivity, specificity, PPV and NPV of the scan at Tt were 46%, 96%, 85% et 78%. The same parameters were 75%, 66%, 53% and 84% for the scan realized at T 0 . The joint scan has showed 22% of false positive. These false positives could be a consequence of an earlier detection of joint alterations by scan. The joint scan should forecast the evolution of joints in patients with rheumatoid arthritis. (author)

  10. Roentgenofunctional investigation of the ankle joint in a long-term period after crural bone fracture

    International Nuclear Information System (INIS)

    Ignat'ev, Yu.T.; Novikov, V.P.

    1989-01-01

    On the basis of the results of clinicoroentgenological and tensographic investigations of 119 patients after traumas of the crural bones and ankle joint (2-36 yrs. ago) the authors showed the importance of roentgenofunctional investigation of the ankle joint. A specially designed footing was proposed. Of 77 patients after intra-articular fractures of the ankle bones various disorders in articular proportions, undetectable on routine roengenography, were diagnosed in 29 by functional roentgenography. Articular changes on roentgenofunctional investigation were revealed in one patient only out of 42 patients with extra-articular fractures of the crural bones. Tensography showed disorders of foot biomechanics in all patients with subluxations in the ankle

  11. GIANT CELL-RICH LESIONS OF BONE AND JOINTS: A ONE YEAR PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Sri Nithisa H

    2016-07-01

    Full Text Available BACKGROUND Giant cell-rich lesions constitute a group of biologically and morphologically diverse bone and joint tumours. The common feature is presence of numerous multinucleated osteoclast-like giant cells. However, they differ from each other by in terms of clinical and radiographic features and in many cases by their distinct morphological features. METHODS All the bone and joint specimens with giant cell-rich lesions received in the period of one year were studied along with clinical and radiological data available. Gross and microscopic findings were noted. RESULTS In a period of one year, 10 cases of giant cell-rich lesions of bone and joints have been studied, which were and correlated with clinical and radiological findings. Five were lesions from bone and two were from joints, which are chondroblastoma, chondromyxoid fibroma, osteoclastoma, aneurysmal bone cyst, pigmented villonodular synovitis, giant cell lesion of tendon sheath, and tendinous xanthoma. CONCLUSION In the present study, variety of giant cell lesions of bone and joints are studied. Of which, the mean age in young patients being 20 years and in elderly patients being 50 years. The common site being lower end of femur.

  12. Open Intramedullary Nailing for Segmental Long Bone Fractures: An ...

    African Journals Online (AJOL)

    the bone only, except in cases where there was a long and narrow middle segment. In such .... method of application, and preservation of extramedullary blood supply.[10,41,42] We .... J Bone Joint Surg Br 1994;76:955‑9. 14. Sekimpi P, Okike ...

  13. Cellular Therapy to Obtain Rapid Endochondral Bone Formation

    Science.gov (United States)

    2008-02-01

    length from the tibial fusion site, and then stop which would be consistent with the resorption being associated with the lack of weight bearing load. In...Defect in the Rat Femur with Use of a Vascularized Periosteal Flap, a Biodegradable Matric, and Bone Morphogenetic Protein. J Bone Joint Surg 87-A(6

  14. Effect of platelet-rich plasma on fibrocartilage, cartilage, and bone repair in temporomandibular joint.

    Science.gov (United States)

    Kütük, Nükhet; Baş, Burcu; Soylu, Emrah; Gönen, Zeynep Burçin; Yilmaz, Canay; Balcioğlu, Esra; Özdamar, Saim; Alkan, Alper

    2014-02-01

    The purpose of the present study was to explore the potential use of platelet-rich-plasma (PRP) in the treatment of temporomandibular joint osteoarthritis (TMJ-OA). Surgical defects were created bilaterally on the condylar fibrocartilage, hyaline cartilage, and bone to induce an osteoarthritic TMJ in rabbits. PRP was applied to the right joints of the rabbits (PRP group), and the left joints received physiologic saline (control group). After 4 weeks, the rabbits were sacrificed for histologic and scanning electron microscopy (SEM) examinations. The data were analyzed statistically. The new bone regeneration was significantly greater in the PRP group (P fibrocartilage and hyaline cartilage was greater in the PRP group, no statistically significant difference was found between the 2 groups. SEM showed better ultrastructural architecture of the collagen fibrils in the PRP group. PRP might enhance the regeneration of bone in TMJ-OA. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  15. Structural joint damage and hand bone loss in patients with rheumatoid arthritis.

    Science.gov (United States)

    Lykke, Midtbøll Ørnbjerg

    2018-03-01

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an important treatment goal. Inhibitors of tumour necrosis factor alpha (TNF-inhibitors) have markedly improved the treatment options in RA patients who fail treatment with conventional synthetic Disease Modifying Anti Rheumatic Drugs (sDMARDS), but their effectiveness with regards to structural joint damage and hand bone loss, predictors thereof and the association with disease activity during treatment have mainly been investigated in randomized controlled trials (RCTs) with limited generalizability due to strict in- and exclusion criteria.
 The main aim of the PhD thesis was to assess and predict structural joint damage and hand bone loss in patients with early and established RA treated with sDMARDs and TNF-inhibitors. This was investigated in two cohorts: A) The "DANBIO X-ray study": an observational, nationwide, longitudinal cohort study of established RA patients treated in clinical practice who initiated TNF-inhibitor treatment after failure of sDMARDs and B) The "OPERA study": a randomized controlled trial of sDMARD-naïve patients with early RA treated with methotrexate (MTX) and intraarticular glucocorticoid injections in combination with adalimumab or placebo-adalimumab. Structural joint damage progression was assessed with the Sharp/van der Heijde radiographic method and hand bone loss was assessed with Digital X-ray Radiogrammetry. 
From the studies presented in the PhD thesis the following was concluded:
 Structural joint damage progression and hand bone loss were significantly lower during two years of TNF-inhibitor treatment compared to the previous two years of sDMARD-treatment in the DANBIO X-ray Study. The majority of patients had

  16. Bone structure of the temporo-mandibular joint in the individuals aged 18-25.

    Science.gov (United States)

    Parafiniuk, M; Gutsch-Trepka, A; Trepka, S; Sycz, K; Wolski, S; Parafiniuk, W

    1998-01-01

    Osteohistometric studies were performed in 15 female and 15 male cadavers aged 18-25. Condyloid process and right and left acetabulum of the temporo-mandibular joint have been studied. Density has been investigated using monitor screen linked with microscope (magnification 80x). Density in the spongy part of the condyloid process was 26.67-26.77%; in the subchondrial layer--72.13-72.72%, and in the acetabular wall 75.03-75.91%. Microscopic structure of the bones of the temporo-mandibular joint revealed no differences when compared with images of compact and cancellous bone shown in the histology textbooks. Sex and the side of the body had no influence on microscopic image and proportional bone density. Isles of chondrocytes in the trabeculae of the spongy structure of the condyloid process were found in 4 cases and isles of the condensed bone resembling the compact pattern in 7 cases.

  17. X-ray and radionuclide investigations of the bones and joints in psoriasis

    International Nuclear Information System (INIS)

    Spuzyak, M.I.; Vasil'ev, A.A.; Belyaev, G.M.; Vikman, Ya.Eh.

    1990-01-01

    Radiography of the bones and joints was performed in 133 psoriatic patients; osteoscintigraphy with 99m Tc-phosphate compounds was also performed in 42 of them. On the basis of x-ray findings 3 types of osteoarticular psoriasis were singled out: psoriatic polyarthritis, psoriatic polyarthrosis and psoriatic arthropathy. The most ample information on the type, activity and spreading of a pathological process in the bones and joints in psoriasis can be obtained from the combination of the x-ray and radionuclide methods

  18. Bone marrow changes adjacent to the sacroiliac joints after pelvic radiotherapy mimicking metastases on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kanberoglu, K.; Mihmanli, I.; Kurugoglu, S.; Ogut, G.; Kantarci, F. [Dept. of Radiology, Istanbul Univ. (Turkey)

    2001-09-01

    Radiation-induced changes in the sacroiliac joints mimicking metastases on MR images were evaluated. Twelve patients who received radiotherapy to the pelvic region due to pelvic malignancy were included in the study. All patients had undergone external beam radiation therapy to the pelvic region, and 2 patients received supplementary internal radiation. The changes in the sacroiliac joints were evaluated. Computed-tomography-guided core bone biopsy from the bone marrow was taken from their corresponding MR sections in 5 of the patients. T1 hypointense and T2 hyperintense areas with ill-defined margins in the bone marrow adjacent to the sacroiliac joints were observed in all patients. On bone scintigraphy all the lesions demonstrated increased activity. Other radiological modalities excluded fracture, soft tissue mass, and osseous destruction. Bone biopsies demonstrated peritrabecular fibrosis and inflammatory cell infiltration. Patients receiving radiotherapy to the pelvis may demonstrate T1 hypointense/T2 hyperintense, ill-defined postradiotherapeutic benign changes in the sacroiliac joints. In the absence of any other signs of disease progression and when the imaging pattern is typical, close radiological follow-up should be sufficient to rule out metastases. (orig.)

  19. Toward an integrated storm surge application: ESA Storm Surge project

    Science.gov (United States)

    Lee, Boram; Donlon, Craig; Arino, Olivier

    2010-05-01

    .surgesymposium.org, organized by the WMO-IOC Joint technical Commission for Oceanography and Marine Meteorology, JCOMM) and following activities, that have been supported by the Intergovernmental Oceanographic Commission (IOC) of UNESCO through JCOMM. The paper also reviews the capabilities of storm surge models, and current status in using Earth Observation (EO) information for advancing storm surge application tools, and further, for improving operational forecasts and warning capability for coastal inundation. In this context, the plans and expected results of the ESA Storm Surge Project (2010-2011) will be introduced.

  20. Nuclear Medicine in Diagnosis and Therapy of Bone and Joint Diseases

    International Nuclear Information System (INIS)

    Riccabona, G.

    1999-01-01

    Concerning bone and joint diseases therapy of rheumatic synovitis (radiosynoviorthesis) was introduced in 1952 before clinically relevant diagnostic procedures were developed. Radionuclides of Sr and later on 99mTc phosphonates then started the wide use of bone scintigraphy since > 30 years. The diagnostic methods have an excellent sensitivity for detection of local abnormalities of bone metabolism, the specificity of such studies, however, is low. Modifications of the technique (3-phase-bone-scintigraphy, pinhole collimators, ROI-technique), increasing knowledge of pathological scan patterns and introduction of other radionuclide studies (67Ga, 201Tl, inflammation scans with 99mTc-leukocytes or 99mTc-HIG) as well as 18FDG-PET have increased the specificity significantly in recent years and improvements of imaging systems (SPECT) also increased the accuracy of diagnostic methods in diseases of bone and joints. Therapy of such diseases has made considerable progress: inflamed, swollen joints can effectively be treated with 90Y-, 186Re, 169Er-colloids or with 165Dy-particles by radiosynoviorthesis. Severe pain due to disseminated bone metastases of cancer or polyarthritis can be controlled by radionuclide therapy with 89Sr, 153Sm-EDTMP, 186Re- or 188Re-HEDP and possibly 117mSn-DTPA with an acceptable risk of myelodepression. Possibilities, technical details and limitations of radionuclide applications for diagnostic and therapeutic purposes must be considered if optimal benefit for individual patients should be achieved. Overall Nuclear Medicine can become an essential element in management of bone and joint diseases. The relationship of Nuclear Medicine to bone and joint pathology is peculiar: In 1952 treatment of rheumatic synovitis by radiosynoviorthesis with 198Au Colloid was started by Fellinger and Schmid before diagnostic approaches to bone pathology existed. Bone scintigraphy was introduced only in 1961 using 85Sr but obviously the unfavourable radiation

  1. Imaging appearance of bone and joint in long-term dialysis recipients

    International Nuclear Information System (INIS)

    Liu Jiayi; Wang Wu; Hong Wen; Huang Zhenguo; Ren An; Zhang Xuezhe

    2009-01-01

    Objective: To analyze the MRI characters of hemodialysis-related osteoarthropathy in long-term dialysis recipients, and to evaluate the diagnostic value of X-ray, CT, and MRI on hemodialysis-related osteoarthropathy. Methods: The shoulders, hips, wrists and lumbar' vertebraes of 32 patients underwent X-ray and CT examinations. Twenty-six of them received MRI examinations. Results: In X-ray of 32 patients, 28 appeared osteoporosis, 11 showed bone resorption, 6 had cystic lesions, 11 had bone sclerosis, 1 had joint swelling, and 19 had soft tissue calcification. In CT of 32 patients, 32 appeared osteoporosis, 9 showed bone resorption, 12 had cystic lesions, 11 had bone sclerosis, 3 had joint swelling, and 19 had soft tissue calcification. In MRI of 26 patients, 6 appeared osteoporosis, 2 showed bone resorption, 14 showed cystic lesions, 5 had bone sclerosis, 15 had joint swelling, and 1 showed soft tissue calcification. Conclusions: X-rays plain film is the first choice for the diagnosis of hemodialysis-related osteopathy, and MRI is the first choice for the diagnosis of hemodialysis-related arthropathy. CT and MRI is pretty useful in the diagnosis of hemodialysis-related osteoarthropathy. (authors)

  2. Centrifugal Compressor Surge Controlled

    Science.gov (United States)

    Skoch, Gary J.

    2003-01-01

    It shows the variation in compressor mass flow with time as the mass flow is throttled to drive the compressor into surge. Surge begins where wide variations in mass flow occur. Air injection is then turned on to bring about a recovery from the initial surge condition and stabilize the compressor. The throttle is closed further until surge is again initiated. Air injection is increased to again recover from the surge condition and stabilize the compressor.

  3. Septic arthritis of a lumbar facet joint: Detection with bone SPECT imaging

    International Nuclear Information System (INIS)

    Swayne, L.C.; Dorsky, S.; Caruana, V.; Kaplan, I.L.

    1989-01-01

    We present a rare case of septic arthritis of a lumbar facet joint with an associated epidural abscess resulting from Staphylococcus aureus. The infection was initially detected with planar bone scintigraphy and precisely localized with single photon emission computed tomography bone scintigraphy, despite an initially negative radiologic evaluation that included radiographs of the lumbar spine, lumbar myelography, and a postmyelography x-ray computed tomography scan. In the appropriate clinical setting, a bone scan demonstrating unilateral increased activity within the spine should raise the suspicion of inflammatory involvement of the posterior elements

  4. METHODS USED FOR THE VIRTUAL HUMAN BONES AND JOINTS RECONSTRUCTION. NORMAL AND PATHOLOGICAL HUMAN JOINTS VIRTUAL SIMULATIONS

    Directory of Open Access Journals (Sweden)

    POPA Laurentiu Dragos

    2015-06-01

    Full Text Available To understand the problems, which appear in every human joint, it is very important to know the anatomy and morphology of the human bones and the way in which the components are working together to realize a normal functionality. For this purpose was used a CAD parametric software which permits to define models with a high degree of difficulty. First, it was used a CT or MRI device to obtain the parallel sections to study each component of the bone. A 3D scanner can be used only for the outer geometry. In the second step the images were transferred to a 2D CAD software, like AutoCAD, where the outer and inner contours of the bone were approximate to polygonal lines composed by many segments. After this, the contours were transferred to a 3D CAD software, like SolidWorks, where, step by step, and section by section, was defined the virtual bone component. Additionally to the main shape can be attached other Loft, Round or Dome shapes. For some components, as vertebrae, mandible or skull bones, can be used a preliminary model obtained by parallel sections. Starting from this, the model can be defined using the main 3D curves and we can get the final virtual solid model. In some simulations, the soft components, as muscles or ligaments, were included in simulations using non-linear virtual springs. Also, sometimes were used implants or prosthetic elements. In the final of the paper, were extracted important conclusions.

  5. A numerical study on stress distribution across the ankle joint: Effects of material distribution of bone, muscle force and ligaments.

    Science.gov (United States)

    Mondal, Subrata; Ghosh, Rajesh

    2017-09-01

    The goal of this study is to develop a realistic three dimensional FE model of intact ankle joint. Three dimensional FE model of the intact ankle joint was developed using computed tomography data sets. The effect of muscle force, ligaments and proper material property distribution of bone on stress distribution across the intact ankle joint was studied separately. Present study indicates bone material property, ligaments and muscle force have influence on stress distribution across the ankle joint. Proper bone material, ligaments and muscle must be considered in the computational model for pre-clinical analysis of ankle prosthesis.

  6. Pathophysiology of the GH/IGF-1 axis : long-term consequences on joints and bone

    NARCIS (Netherlands)

    Claessen, Kim Maria Johanna Aldegonda

    2014-01-01

    In this thesis, a number of observations are described in acromegaly patients with cured or biochemically well-controlled disease during long-term follow-up. These observations focus on the long-term consequences of the disease on joints and bone. In addition, we investigated the role of the Growth

  7. [Bone and joint decade--"mile step" in diagnostics and treatment of movement system diseases?].

    Science.gov (United States)

    Brongel, Leszek; Lorkowski, Jacek; Hładki, Waldemar; Trybus, Marek

    2006-01-01

    Musculoskeletal disorders affect hundreds of millions of people across the world and are the most common causes of severe long-term pain and physical disability. The impact from such disorders on the individual and on society let to propose by WHO for the Decade of the Bone and Joint from 2000 to 2010. The goal of the Decade is to improve the health-related quality of life for people with musculoskeletal disorders throughout the world and this could be achieved by raising awareness of the growing burden of bone and joint diseases on society, promoting prevention and treatment and advancing understanding of musculoskeletal disorders through research. The main fields of interest during the Decade are joint diseases, spinal disorders and low back pain, osteoporosis and severe trauma of the extremities. In our Department we study problems concerning on traumatology of old patients, multitrauma injury, biomechanics in spinal disorders, in degenerative joint disease and foot diseases. Apart from contemporary imaging methods like US or CT we use pedobarographic diagnostics and fotogrammetric examination. In this study we present strategic goals and the summary of our ongoing projects in our Department related to the goals of the Bone and Joint Decade.

  8. The value of SPECT bone scans in diagnosis of patients with zygapophseal joint pain

    International Nuclear Information System (INIS)

    Hu Jiajia; Liang Yu; Li Biao; Zhu Chengmo; Chen Gang; Wang Chao; Tian Weijia; Qu Liumin

    2008-01-01

    Objective: Bone scintigraphy with SPECT of the lumbar spine allows identification of lesions not seen with planar imaging, in patients with chronic low back pain. The aim of this study was to investigate the value of SPECT bone scans in diagnosis of patients with zygapophyseal joint pain. Methods: Thirty-five consecutive patients in Ruijin hospital from July 2006 to March 2007 with low back pain were en- rolled. All patients underwent bone scintigraphy with SPECT. According to the results of SPECT, patients with isotope-uptake joints received injections at the levels where abnormalities were identified on the scan. Patients with negative scans received other treatment (conservative treatment or surgery) but not facet joint injection. Clinical records were collected at 1-, 3-, and 6-month in SPECT-positive group after their initial treatment. And the SPECT-negative group were followed up at 6-month after therapy. Statistical analysis was performed with SPSS 10.0. Patients with SPECT-positive and -negative results were performed with the grouped t-test. Visual analog scales (VAS) were with the paired t-test used in patients with positive scans at before and after treatment. Results: Fifteen cases had facetal uptake of isotope on SPECT bone scans. After facet joint injection, 85.7% patients (12/14, 1 patient was excluded for operation) had improvement in pain score at 1-month, 78.6% (11/14) at 3-month, and 50.0% (7/14) at 6-month. Of 20 negative cases, 3 were treated by surgery and 17 by conservative treatment. All 20 cases were followed up for 6 months and 70.0% (14/20) had long time pain relief. Conclusion: SPECT bone scans are helpful to identify patients with low back pain who would benefit from facet joint injections. (authors)

  9. MRI of the wrist and finger joints in inflammatory joint diseases at 1-year interval: MRI features to predict bone erosions

    International Nuclear Information System (INIS)

    Savnik, Anette; Malmskov, Hanne; Graff, Lykke B.; Danneskiold-Samsoee, Bente; Bliddal, Henning; Thomsen, Henrik S.; Nielsen, Henrik; Boesen, Jens

    2002-01-01

    The aim of this study was to assess the ability of MRI determined synovial volumes and bone marrow oedema to predict progressions in bone erosions after 1 year in patients with different types of inflammatory joint diseases. Eighty-four patients underwent MRI, laboratory and clinical examination at baseline and 1 year later. Magnetic resonance imaging of the wrist and finger joints was performed in 22 patients with rheumatoid arthritis less than 3 years (group 1) who fulfilled the American College of Rheumatology (ACR) criteria for rheumatoid arthritis, 18 patients with reactive arthritis or psoriatic arthritis (group 2), 22 patients with more than 3 years duration of rheumatoid arthritis, who fulfilled the ACR criteria for rheumatoid arthritis (group 3), and 20 patients with arthralgia (group 4). The volume of the synovial membrane was outlined manually before and after gadodiamide injection on the T1-weighted sequences in the finger joints. Bones with marrow oedema were summed up in the wrist and fingers on short-tau inversion recovery sequences. These MRI features was compared with the number of bone erosions 1 year later. The MR images were scored independently under masked conditions. The synovial volumes in the finger joints assessed on pre-contrast images was highly predictive of bone erosions 1 year later in patients with rheumatoid arthritis (groups 1 and 3). The strongest individual predictor of bone erosions at 1-year follow-up was bone marrow oedema, if present at the wrist at baseline. Bone erosions on baseline MRI were in few cases reversible at follow-up MRI. The total synovial volume in the finger joints, and the presence of bone oedema in the wrist bones, seems to be predictive for the number of bone erosions 1 year later and may be used in screening. The importance of very early bone changes on MRI and the importance of the reversibility of these findings remain to be clarified. (orig.)

  10. Bone signal abnormality, as seen on knee joint MRI : relationship between its location and associated injury

    International Nuclear Information System (INIS)

    Kim, Young Nam; Kim, Baek Hyun; Jung, Hoe Seok; Na, Eui Sung; Seol, Hye Young; Cha, In Ho; Lim, Hong Chul

    1998-01-01

    The purpose of the study was to evaluate the relationship between the location of bone signal abnormality and associated injury, as seen on MR, in patients with acute knee joint injury. Materials and Methods: Thirty-six patients with acute knee injury and bone signal abnormalities on MR were included in this study. The femur and tibia were each divided into six compartments, namely the anteromedial, medial, posteromedial,anterolateral, lateral, and posterolateral ; these were obtained in each knee joint. We evaluated the location of bone signal abnormality and the corresponding arthroscopic or operative findings of injury to ligaments and menisci. Cases with signal abnormalities involving more than three compartments were excluded. Results : Bone signal abnormalities were demonstrated in 51 compartments. Most(84%, 43/51) were noted in the lateral half of the knee joint, the most common location being the tibio- posterolateral compartment(13/51). The femoro-lateral(11/51) and tibio- anterolateral compartment(8/51) were the next most common locations. All cases(13/13)with bone signal abnormality in the tibio- posterolateral compartment had tears at the anterior cruciate ligament,while 9 of 11 cases(81%) with abnormality in the femoro- lateral compartment had tears at the anterior cruciate ligament. Six of eight cases(75%) with signal abnormality in the tibio- anterolateral compartment had tears at the posterior cruciate ligament ; 31 of 43 cases (72%) with abnormality in the lateral half of the knee joint had tears at the medial collateral ligament. Six of eight cases(75%) with signal abnormality in the medial half of the knee joint had tears at the medial meniscus, but no lateral meniscal tear was found. Among patients with signal abnormality in the lateral half of the knee joint, the tear was lateral meniscal in nine of 43 cases(21%) and medial meniscal in six of 43(14%). Conclusion : The location of bone signal abnormality, as seen on knee MR, inpatients with

  11. Role of Tc-99m Sulesomab in the diagnosis of bone and joint infections

    International Nuclear Information System (INIS)

    Iyengar, K.P.; Nadkarni, J.B.; Vinjamuri, S.

    2005-01-01

    Confirming the presence of deep-seated infection in the bones and joints can be difficult, especially when routine laboratory tests and plain radiographs are inconclusive. The aim of this study was to assess the role of Tc-99m labelled anti-granulocyte monoclonal antibody Fab' fragment (Sulesomab) in bone and joint infection. Scans of 95 patients with suspected skeletal/ joint infection were studied and correlated with clinical information. Referrals consisted of suspected infection in prosthetic total joint replacements (38), long bones (32), primary joints (12) and feet (13). There were 48 female and 47 male referrals with a mean age of 60 rears (Range= 16 to 89 years). Results of routine haemogram (ESR, CRP and full blood count), plain radiographs, relevant microbiology, culture and /or histology were collected in all patients. All patients had positive Tc-99m MDP bone scan prior to Tc-99m Sulesomab scintigraphy. Patients were classified into true positives, true negatives, false positives and false negatives on the basis of final diagnosis arrived at by conclusive microbiology, surgery, complementary investigations like CT/MRI and clinical follow-up. Fifty-eight out of 95 patients had normal or equivocal blood test results. Plain radiographs revealed no abnormality or were inconclusive of infection in more than half of the patients. The Tc-99m Sulesomab scans were found to be positive in 38 patients and 57 had normal scans. Outcome classification revealed 29 true positives, 56 true negatives, 9 false positives and one false negative with an overall sensitivity of 96.66 %, specificity of 86.15 % and negative predictive value of 98.24%. Individual sensitivity, specificity and diagnostic accuracy of each category were compared. The diagnostic accuracy was found to be the highest for long bone infections (96.87%) and least for primary joint infections (83.33%). Overall the sensitivities were better than specificity in all categories. We therefore conclude that Tc

  12. [Correlation analysis of bone marrow edema degree and serum inflammatory factors change with knee joint pain symptoms in patients with bone contusion around the knee joint].

    Science.gov (United States)

    Li, Songiun; An, Rongze; Wang, Zhaojie; Kuang, Lipeng; Tan, Weiyuan; Fang, Cunxun

    2014-05-01

    To explore the correlation between the degree of bone marrow edema (BME) and the content change of tumor necrosis factor alpha (TNF-alpha) and matrix metalloproteinase 3 (MMP-3) and the knee pain symptoms in patients with bone contusion around the knee joint. Thirty patients (30 knees) of bone contusion around the knee joint were chosen as the trial group between October 2009 and April 2012. According to visual analogue scale (VAS), 30 patients were divided into mild group (10 cases), moderate group (10 cases), and severe group (10 cases); according to MRI morphological changes, the patients were divided into type I group (12 cases), type II group (11 cases), and type III group (7 cases). Ten patients (10 knees) with soft tissue injury of the knee were chosen as control group. No significant difference was found (P > 0.05) in gender, age, causes, side, and admission time after injury between 2 groups. The serum contents of MMP-3 and TNF-alpha were detected and statistically analysed between different degrees of pain groups and between different degrees of BME groups. Correlation was analysed between BME and inflammatory factor changes and VAS score. The MMP-3 and TNF-alpha contents in trial group [(29.580 +/- 6.870) (microg/L and (23.750 +/- 7.096) ng/L] were significantly higher than those in control group [(8.219 +/- 1.355) microg/L and (6.485 +/- 1.168) ng/L] (t = 9.686, P = 0.000; t = 7.596, P =0.000). The MMP-3 and TNF-alpha contents in patients with different degrees of pain and BME were significantly higher than those in patients of control group (P pain (P 0.05). Multiple linear regression analysis showed that TNF-alpha content was significantly correlated with VAS score (P = 0.000). Knee pain symptoms are not related to the degree of BME in patients with bone contusion around the knee joint. Inflammatory factor TNF-alpha content is the main influence factor of knee joint pain symptoms.

  13. Correlation between bone contusion and ligament, menisci injury of knee joint

    International Nuclear Information System (INIS)

    Zhang Lijuan; Li Pei; Tu Changzhuo; Wu Guangren; Qi Yuliang; Yan Xiaoqun

    2004-01-01

    Objective: To evaluate the correlation between bone contusion and ligament, meniscus injury of knee joint with MR imaging. Methods: Thirty-five patients with acute trauma of knee joint were studied retrospectively. All eases showed negative on X-ray and bone cont, -sion on MR imaging. Results: in all patients, ligament and meniscus injury were seen in 25 cases (71%), incorporate anterior cruciate ligament injury in 12 cases, posterior cruciate ligament in 6, tibial collateral ligament in 8 cases, fibular collateral ligament in 6 cases, medial meniscus tear in 4 cases, lateral meniscus tear in 5 cases, and hydrops in 29 cases. There were only 3 patients with ligament or meniscus injury but no bone contusion during the same period. Conclusion: It is necessary to check by MR for the patients with acute trauma of knee joint, who have clinical symptom such as ache, swelling, move un-freely showing bone contusion on MR Imaging but without any abnormality on X-ray in order to avoid failure in diagnosing injury of ligament and meniscus. (authors)

  14. Bone marrow edema of the knee joint; Differenzialdiagnosen des Knochenmarkoedems am Kniegelenk

    Energy Technology Data Exchange (ETDEWEB)

    Breitenseher, M.J. [Waldviertelklinikum Horn (Austria). Institut fuer Radiologie; Universitaetsklinik fuer Radiodiagnostik Wien (Austria). Abteilung Osteologie; Kramer, J. [Institut fuer CT- und MRT-Diagnostik, Linz (Austria); Mayerhoefer, M.E. [Universitaetsklinik fuer Radiodiagnostik Wien (Austria). Abteilung Osteologie; Aigner, N. [Orthopaedisches Krankenhaus Speising, Erste Orthopaedische Abteilung, Wien (Austria); Hofmann, S. [LKH Stolzalpe (Austria). Orthopaedische Abteilung

    2006-01-01

    Bone marrow edema of the knee joint is a frequent clinical picture in MR diagnostics. It can be accompanied by symptoms and pain in the joint. Diseases that are associated with bone marrow edema can be classified into different groups. Group 1 includes vascular ischemic bone marrow edema with osteonecrosis (synonyms: SONK or Ahlbaeck's disease), osteochondrosis dissecans, and bone marrow edema syndrome. Group 2 comprises traumatic or mechanical bone marrow edema. Group 3 encompasses reactive bone marrow edemas such as those occurring in gonarthrosis, postoperative bone marrow edemas, and reactive edemas in tumors or tumorlike diseases. Evidence for bone marrow edema is effectively provided by MRI, but purely morphological MR information is often unspecific so that anamnestic and clinical details are necessary in most cases for definitive disease classification. (orig.) [German] Das Knochenmarkoedem des Kniegelenks ist ein haeufiges Erscheinungsbild in der MR-Diagnostik. Es kann mit Symptomen und Schmerzen des Gelenks einhergehen. Erkrankungen, die mit einem Knochenmarkoedem vergesellschaftet sind, koennen in verschiedene Gruppen eingeteilt werden. Zur 1. Gruppe gehoeren das vaskulaer-ischaemische Knochenmarkoedem mit Osteonekrose (Synonyme SONK oder Morbus Ahlbaeck), die Osteochondrosis dissecans und das Knochenmarkoedemsyndrom, zur 2. Gruppe das traumatologische oder mechanische Knochenmarkoedem. In der 3. Gruppe werden reaktive Knochenmarkoedeme zusammengefasst wie bei Gonarthrose, postoperative Knochenmarkoedeme und reaktive Oedeme bei Tumor oder tumoraehnlichen Erkrankungen. Der Nachweis eines Knochenmarkoedems gelingt mit der MRT sehr sensitiv, die rein morphologische MR-Information ist jedoch oft unspezifisch, sodass anamnestische und klinische Informationen fuer die sichere Zuordnung einer Erkrankung in den meisten Faellen notwendig sind. (orig.)

  15. Bone bruise, lipohemarthrosis, and joint effusion in CT of non-displaced hip fracture

    International Nuclear Information System (INIS)

    Geijer, Mats; Dunker, Dennis; Collin, David; Goethlin, Jan H.

    2012-01-01

    Background. A suspected occult hip fracture after normal radiography is not uncommon in an elderly person after a fall. Despite a lack of robust validation in the literature, computed tomography (CT) is often used as secondary imaging. Purpose. To assess the frequency and clinical utility of non-cortical skeletal and soft tissue lesions as ancillary fracture signs in CT diagnosis of occult hip fractures. Material and Methods. All fracture signs (cortical and trabecular fractures, bone bruise, joint effusion, and lipohemarthrosis) were recorded in 231 hip low-energy trauma cases with CT performed after normal or equivocal radiography in two trauma centers. Results. There were no fracture signs in 110 patients. Twelve of these had a joint effusion. In 121 patients with 46 cervical hip fractures and 75 trochanteric fractures one or more fracture signs were present. Cortical fractures were found in 115 patients. Bone bruise was found in 119 patients, joint effusion in 35, and lipohemarthrosis in 20 patients. Conclusion. Ancillary signs such as bone bruise and lipohemarthrosis can strengthen and sometimes indicate the diagnosis in CT of occult hip fractures. Joint effusion is a non-specific sign

  16. Bone bruise, lipohemarthrosis, and joint effusion in CT of non-displaced hip fracture

    Energy Technology Data Exchange (ETDEWEB)

    Geijer, Mats (Center for Medical Imaging and Physiology, Skaane University Hospital, Lund University, Lund (Sweden)), Email: mats@geijer.info; Dunker, Dennis; Collin, David; Goethlin, Jan H. (Department of Radiology, Sahlgrenska University Hospital, Moelndal (Sweden))

    2012-03-15

    Background. A suspected occult hip fracture after normal radiography is not uncommon in an elderly person after a fall. Despite a lack of robust validation in the literature, computed tomography (CT) is often used as secondary imaging. Purpose. To assess the frequency and clinical utility of non-cortical skeletal and soft tissue lesions as ancillary fracture signs in CT diagnosis of occult hip fractures. Material and Methods. All fracture signs (cortical and trabecular fractures, bone bruise, joint effusion, and lipohemarthrosis) were recorded in 231 hip low-energy trauma cases with CT performed after normal or equivocal radiography in two trauma centers. Results. There were no fracture signs in 110 patients. Twelve of these had a joint effusion. In 121 patients with 46 cervical hip fractures and 75 trochanteric fractures one or more fracture signs were present. Cortical fractures were found in 115 patients. Bone bruise was found in 119 patients, joint effusion in 35, and lipohemarthrosis in 20 patients. Conclusion. Ancillary signs such as bone bruise and lipohemarthrosis can strengthen and sometimes indicate the diagnosis in CT of occult hip fractures. Joint effusion is a non-specific sign

  17. [Automated Assessment for Bone Age of Left Wrist Joint in Uyghur Teenagers by Deep Learning].

    Science.gov (United States)

    Hu, T H; Huo, Z; Liu, T A; Wang, F; Wan, L; Wang, M W; Chen, T; Wang, Y H

    2018-02-01

    To realize the automated bone age assessment by applying deep learning to digital radiography (DR) image recognition of left wrist joint in Uyghur teenagers, and explore its practical application value in forensic medicine bone age assessment. The X-ray films of left wrist joint after pretreatment, which were taken from 245 male and 227 female Uyghur nationality teenagers in Uygur Autonomous Region aged from 13.0 to 19.0 years old, were chosen as subjects. And AlexNet was as a regression model of image recognition. From the total samples above, 60% of male and female DR images of left wrist joint were selected as net train set, and 10% of samples were selected as validation set. As test set, the rest 30% were used to obtain the image recognition accuracy with an error range in ±1.0 and ±0.7 age respectively, compared to the real age. The modelling results of deep learning algorithm showed that when the error range was in ±1.0 and ±0.7 age respectively, the accuracy of the net train set was 81.4% and 75.6% in male, and 80.5% and 74.8% in female, respectively. When the error range was in ±1.0 and ±0.7 age respectively, the accuracy of the test set was 79.5% and 71.2% in male, and 79.4% and 66.2% in female, respectively. The combination of bone age research on teenagers' left wrist joint and deep learning, which has high accuracy and good feasibility, can be the research basis of bone age automatic assessment system for the rest joints of body. Copyright© by the Editorial Department of Journal of Forensic Medicine.

  18. Association of bone marrow edema with temporomandibular joint (TMJ) osteoarthritis and internal derangements.

    Science.gov (United States)

    Wahaj, Aiyesha; Hafeez, Kashif; Zafar, Muhammad Sohail

    2017-01-01

    This study reviewed the dental literature in order to determine the association of bone marrow edema with osteoarthritis and temporomandibular joint (TMJ) internal derangement disorders. A literature search was performed using electronic databases PubMed/Medline (National Library of Medicine, Bethesda, Maryland) and Cochrane for articles published during the last 15 years (January 2000-December 2014). A predetermined inclusion and exclusion criteria were used for filtering the scientific papers. Research articles fulfilling the basic inclusion criteria were included in the review. The reviewed studies showed that bone marrow edema is found in painful joints with osteoarthritis in a majority of cases. A few cases with no pain or significant degenerative changes are reported to have a bone marrow edema pattern as well. Bone marrow edema, increased fluid level, and pain are associated with osteoarthritis in the majority of patients reporting TMJ arthritis. Degenerative and disc displacement conditions are multifactorial and require further investigations. Magnetic resonance imaging can be employed to detect bone marrow edema even in the absence of pain and clinical symptoms in the patients of internal derangements.

  19. 99mTc-MDP combined blood pool and bone phase radionuclide imaging in papain-injected carpal joints

    International Nuclear Information System (INIS)

    Metcalf, M.R.; Twardock, A.R.; Sanecki, R.K.

    1985-01-01

    Scintigraphic changes, i.e., increased activity, were induced by 1% papain, dissolved in phosphate-buffered physiologic saline (pH 7.4), injected into one antebrachiocarpal joint in each of eight dogs. Scintigraphic evaluation was by the use of combined blood pool and bone phase scintigraphy of affected and normal carpi over a 28-day period. The qualitative and quantitative scintigraphic appearance in injected carpal joints were very similar in both blood pool and bone phases. The clinical use of combined blood pool and bone phase scintigraphy to diagnose early inflammatory joint changes appears limited

  20. Bone mineral density in patients with destructive arthrosis of the hip joint.

    Science.gov (United States)

    Okano, Kunihiko; Aoyagi, Kiyoshi; Enomoto, Hiroshi; Osaki, Makoto; Chiba, Ko; Yamaguchi, Kazumasa

    2014-05-01

    Recent reports have shown the existence of subchondral insufficiency fracture in rapidly destructive arthrosis of the hip joint (RDA), and the findings suggest that osteopenia is related to the pathogenesis of the rapid progression of this disease. Therefore, we measured bone mineral density (BMD) in RDA patients. We measured BMD of the lumbar spine, radius, and calcaneus using dual-energy X-ray absorptiometry in 19 patients with RDA and 75 with osteoarthritis of the hip (OA) and compared BMD at different skeletal sites between RDA and OA patients. No significant differences were observed in BMD of the lumbar spine, ultradistal radius, mid-radius, and calcaneous between the RDA and OA groups. Our data suggest that RDA is not accompanied by generalized osteoporosis. Factors other than generalized bone status, for example, BMD around the affected hip joint before destruction, need to be analyzed to elucidate the pathophysiological mechanism of RDA.

  1. Distribution of polyethylene wear debris and bone particles in granuloma tissue around total hip joint replacements

    Czech Academy of Sciences Publication Activity Database

    Zolotarevova, E.; Lapčíková, Monika; Šlouf, Miroslav; Entlicher, G.; Pokorný, D.; Veselý, F.; Sosna, A.

    2008-01-01

    Roč. 18, č. 2 (2008), s. 173-174 ISSN 1120-7000. [Domestic Meeting of the European Hip Society /8./. 11.06.2008-13.06.2008, Madrid] R&D Projects: GA MŠk 2B06096 Institutional research plan: CEZ:AV0Z40500505 Keywords : wear debris * bone particles * total hip joint replacement Subject RIV: CD - Macromolecular Chemistry www. hip -int.com

  2. Knee joint pain potentially due to bone alterations in a knee osteoarthritis patient.

    Science.gov (United States)

    Komatsu, Masatoshi; Nakamura, Yukio; Kamimura, Mikio; Uchiyama, Shigeharu; Mukaiyama, Keijiro; Ikegami, Shota; Kato, Hiroyuki

    2014-12-01

    Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional disability worldwide. However, the etiology of this condition is still largely unknown. We report the clinical course of an elderly man with knee OA. Plain radiographs and MRI examinations performed during follow-up suggested that the pathophysiology of the patient's knee OA and joint pain may have been primarily due to bone alterations.

  3. Bone and/or joint attachment is a risk factor for local recurrence of myxofibrosarcoma

    International Nuclear Information System (INIS)

    Kaya, Mitsunori; Wada, Takuro; Nagoya, Satoshi; Yamashita, Toshihiko

    2011-01-01

    Myxofibrosarcoma is characterized by a high local recurrence rate despite optimal surgical treatment. The definition of prognostic factors for recurrence offers high-risk patients a closer follow-up and a multidisciplinary therapeutic approach. A cohort of 23 patients treated for primary myxofibrosarcoma was retrospectively analyzed. The patients (sex and age), tumors (size, stage, tumor location, bone and/or joint attachment), radiological findings (abnormal signal extension in MRI), histological findings (FNCLCC grade and microscopic extension along the muscle fascia), and treatment (surgical margin) characteristics were included in univariate prognostic factor analysis. After a median follow-up of 63.3 months (range 15-191), the overall recurrence rate was 34.7%. Median time between initial surgery and recurrence was 24.8 months (range 8-52). Inadequate surgical margins (p=0.026) and bone and/or joint attachment (p=0.001) were associated with an increased recurrence rate. For the further improvement of local recurrence-free survival of patients with myxofibrosarcoma, accurate diagnosis of the tumor extension and adequate planning for the surgical margin should be focused on in cases with bone and/or joint attachment. (author)

  4. The value of spiral CT scan on fracture of ankle joint and tarsal bones

    International Nuclear Information System (INIS)

    Li Zhaoli; Liang Jingyin; Pan Zhifeng

    2009-01-01

    Objective: To study the value of spiral CT scan on the fracture of ankle joint and tarsal bones. Methods: 43 cases with the fracture of ankle joint and tarsal bones were collected and analyzed. All the cases were examined by plain film radiography and spiral CT thin slice scan. Multi-planar reformation (MPR), surface shaded display (SSD) and other techniques of image post-processing were performed in 35 cases of them. Results: Spiral CT scan could demonstrate more fractures than plain film radiography in 28 cases(65.1%). There are 15 cases (34.9%) which are normal in plain film radiography but abnormal in Spiral CT scan. Spiral CT could demonstrate the different length, width, direction and number of linear low density shadow. SSD and MPR were performed again in the cases with avulsion fracture and fragmental fracture to demonstrate the fracture direction and the shape, size and location of fragments more clearly. Conclusion: Spiral CT thin slice scan with image post-processing techniques can play an important role in fracture of ankle joint and tarsal bones. (authors)

  5. 3-phase bone imaging and SPECT in the follow up of patients with allogenic vascularized knee joint transplants

    International Nuclear Information System (INIS)

    Manthey, N.; Tatsch, K.; Hahn, K.; Kirschner, M.H.; Nerlich, A.; Hofmann, G.O.

    2001-01-01

    Vascularized allotransplantation of knee joints under immunosuppression is a novel approach in orthopedic surgery. During the postoperative course immunosuppressive management depends on perfusion and viability of the graft. Aim: Evaluation of different diagnostic tools in regard to their usefulness and reliability to provide information about microvascularity and viability of vascularized knee joint allografts. Methods: Four patients with allogenic knee joint transplants were studied up to 26 months after transplantation with 3-phase bone scans and SPECT. The results were compared with duplex sonography, angiography, and histology. Results: Two cases without complications were characterized by adequate perfusion in duplex sonography, angiography and early bone scans. Late bone scans demonstrated increased bone metabolism of the transplant. Corresponding biopsy revealed viable bone cells. In one case with partial thrombosis and one case with complete thrombosis of the transplant vessels rapidly decreasing or missing perfusion was detected by duplex sonography, angiography, and bloodpool scintigraphy. Late bone scans showed reduced or absent bone metabolism. Biopsy demonstrated necrotic bone tissue. Due to the advantage of a tomographic technique SPECT allowed a more reliable assessment of graft viability as compared to planar imaging. Conclusion: Our findings confirm bone scintigraphy as a valuable diagnostic tool in patients with allogenic vascularized knee joint transplants. In contrast to other diagnostic approaches, scintigraphy provides reliable information on both viability and perfusion of the transplant within a single non-invasive clinical investigation. (orig.)

  6. 3-phase bone imaging and SPECT in the follow up of patients with allogenic vascularized knee joint transplants

    Energy Technology Data Exchange (ETDEWEB)

    Manthey, N.; Tatsch, K.; Hahn, K. [Dept. of Nuclear Medicine, Klinikum Grosshadern, Ludwig-Maximilians-Univ. of Munich (Germany); Kirschner, M.H. [Dept. of Surgery, Klinikum Grosshadern, Ludwig-Maximilians-Univ. of Munich (Germany); Nerlich, A. [Inst. of Pathology, Klinikum Grosshadern, Ludwig-Maximilians-Univ. of Munich (Germany); Hofmann, G.O. [Trauma Center Murnau (Germany)

    2001-12-01

    Vascularized allotransplantation of knee joints under immunosuppression is a novel approach in orthopedic surgery. During the postoperative course immunosuppressive management depends on perfusion and viability of the graft. Aim: Evaluation of different diagnostic tools in regard to their usefulness and reliability to provide information about microvascularity and viability of vascularized knee joint allografts. Methods: Four patients with allogenic knee joint transplants were studied up to 26 months after transplantation with 3-phase bone scans and SPECT. The results were compared with duplex sonography, angiography, and histology. Results: Two cases without complications were characterized by adequate perfusion in duplex sonography, angiography and early bone scans. Late bone scans demonstrated increased bone metabolism of the transplant. Corresponding biopsy revealed viable bone cells. In one case with partial thrombosis and one case with complete thrombosis of the transplant vessels rapidly decreasing or missing perfusion was detected by duplex sonography, angiography, and bloodpool scintigraphy. Late bone scans showed reduced or absent bone metabolism. Biopsy demonstrated necrotic bone tissue. Due to the advantage of a tomographic technique SPECT allowed a more reliable assessment of graft viability as compared to planar imaging. Conclusion: Our findings confirm bone scintigraphy as a valuable diagnostic tool in patients with allogenic vascularized knee joint transplants. In contrast to other diagnostic approaches, scintigraphy provides reliable information on both viability and perfusion of the transplant within a single non-invasive clinical investigation. (orig.)

  7. Automated bone segmentation from large field of view 3D MR images of the hip joint

    Science.gov (United States)

    Xia, Ying; Fripp, Jurgen; Chandra, Shekhar S.; Schwarz, Raphael; Engstrom, Craig; Crozier, Stuart

    2013-10-01

    Accurate bone segmentation in the hip joint region from magnetic resonance (MR) images can provide quantitative data for examining pathoanatomical conditions such as femoroacetabular impingement through to varying stages of osteoarthritis to monitor bone and associated cartilage morphometry. We evaluate two state-of-the-art methods (multi-atlas and active shape model (ASM) approaches) on bilateral MR images for automatic 3D bone segmentation in the hip region (proximal femur and innominate bone). Bilateral MR images of the hip joints were acquired at 3T from 30 volunteers. Image sequences included water-excitation dual echo stead state (FOV 38.6 × 24.1 cm, matrix 576 × 360, thickness 0.61 mm) in all subjects and multi-echo data image combination (FOV 37.6 × 23.5 cm, matrix 576 × 360, thickness 0.70 mm) for a subset of eight subjects. Following manual segmentation of femoral (head-neck, proximal-shaft) and innominate (ilium+ischium+pubis) bone, automated bone segmentation proceeded via two approaches: (1) multi-atlas segmentation incorporating non-rigid registration and (2) an advanced ASM-based scheme. Mean inter- and intra-rater reliability Dice's similarity coefficients (DSC) for manual segmentation of femoral and innominate bone were (0.970, 0.963) and (0.971, 0.965). Compared with manual data, mean DSC values for femoral and innominate bone volumes using automated multi-atlas and ASM-based methods were (0.950, 0.922) and (0.946, 0.917), respectively. Both approaches delivered accurate (high DSC values) segmentation results; notably, ASM data were generated in substantially less computational time (12 min versus 10 h). Both automated algorithms provided accurate 3D bone volumetric descriptions for MR-based measures in the hip region. The highly computational efficient ASM-based approach is more likely suitable for future clinical applications such as extracting bone-cartilage interfaces for potential cartilage segmentation.

  8. Second carpal bone slab fracture and subluxation of the middle carpal joint in a horse subsequent to arthrodesis of the carpometacarpal joint.

    Science.gov (United States)

    MacKay, Angela V; Panizzi, Luca; Sparks, Holly D; Barber, Spencer M

    2015-02-01

    To report complications of arthrodesis of the carpometacarpal (CMC) joint using a drilling technique in an adult horse. Case report. Horse (n = 1). A 12-year-old Quarter Horse mare with CMC osteoarthritis (CMC-OA) had arthrodesis under general anesthesia in right lateral recumbency. Under fluoroscopic guidance, a 4.5 mm drill bit was inserted at 3 drilling sites 5-6 cm into the CMC joint and was fanned 30-45° in the plane of the joint and 5-10° in the long axis of the limb to destroy articular cartilage and expose the subchondral bone. The horse presented 2 weeks after surgery for severe lameness of the operated limb. A slab fracture of the 2nd carpal bone (C2) and subluxation of the middle carpal (MC) joint was diagnosed. The horse was humanely euthanatized due to poor prognosis. The fanning technique of arthrodesis of the CMC joint may lead to fracture of carpal bones, joint instability, and MC joint subluxation. A balance between articular surface destruction and maintenance of joint stability should be achieved when using this technique. © Copyright 2014 by The American College of Veterinary Surgeons.

  9. Hemochromatosis: abnormalities of bones and joints: a case report and literature review

    International Nuclear Information System (INIS)

    Farao, S.R.F.; Pereira, E.M.; Harima, H.A.; Rocha Correa Fernandes, A. da; Pavin, A.E.

    1989-01-01

    The authors report a case of a 49 years-old male patient with emphasis in the arthropathy of hemochromatosis. The arthropathy was the first manifestation: the patient had been complaining of pain on the right hip for eight years. The other specific clinical manifestations: diabetes, abnormal pigmentation appeared after six years. The roentgenographic features of bone and joint involvement include abnormalites at metacarpophalangeal joints with osteophytes on the metacarpal heads and in the hip, joint space narrowing, was seen. In the knee involvement is characterized by subchondral cyst and osteophytosis. Laboratory analysis are: serum iron = 191 mg/dl (normal value: 50-150 mg/dl), ferritin > 400 ng/ml (normal value: 42-26 ng/ml). Iron within the parenchymal cells of the liver cirrhosis was detected by hepatic biopsy. Hemochromatosis was pathologically characterized by tissue damage produced by iron deposition. (author) [pt

  10. Medial joint line bone bruising at MRI complicating acute ankle inversion injury: What is its clinical significance?

    International Nuclear Information System (INIS)

    Chan, V.O.; Moran, D.E.; Shine, S.; Eustace, S.J.

    2013-01-01

    Aim: To assess the incidence and clinical significance of medial joint line bone bruising following acute ankle inversion injury. Materials and methods: Forty-five patients who underwent ankle magnetic resonance imaging (MRI) within 2 weeks of acute ankle inversion injury were included in this prospective study. Integrity of the lateral collateral ligament complex, presence of medial joint line bone bruising, tibio-talar joint effusion, and soft-tissue swelling were documented. Clinical follow-up at 6 months was carried out to determine the impact of injury on length of time out of work, delay in return to normal walking, delay in return to sports activity, and persistence of medial joint line pain. Results: Thirty-seven patients had tears of the anterior talofibular ligament (ATFL). Twenty-six patients had medial joint line bone bruising with altered marrow signal at the medial aspect of the talus and congruent surface of the medial malleolus. A complete ATFL tear was seen in 92% of the patients with medial joint line bone bruising (p = 0.05). Patients with an ATFL tear and medial joint line bone bruising had a longer delay in return to normal walking (p = 0.0002), longer delay in return to sports activity (p = 0.0001), and persistent medial joint line pain (p = 0.0003). There was no statistically significant difference in outcome for the eight patients without ATFL tears. Conclusion: Medial joint line bone bruising following an acute ankle inversion injury was significantly associated with a complete ATFL tear, longer delay in the return to normal walking and sports activity, as well as persistent medial joint line pain. Its presence should prompt detailed assessment of the lateral collateral ligament complex, particularly the ATFL

  11. [The reference of normal values of the sacroiliac joint index in bone scintigraphy].

    Science.gov (United States)

    Sebastjanowicz, Przemysław; Iwanowski, Jacek; Piwowarska-Bilska, Hanna; Elbl, Bogumiła; Birkenfeld, Bożena

    Scintigraphy of sacroiliac joints as functional imaging provides unique information on the existing disease process. By using radiopharmaceuticals that allow imaging of the metabolic activity within the joint, it is possible to assess the stage of the disease, even when there are no lesions in radiological images. Quantitative analysis of scintigrams of sacroiliac joints is performed by comparing the uptake in both of them in relation to the uptake in the sacral bone area. The values of sacroiliac (SI/S) indices are influenced by the age of the patient, sex, state of health, and a range of individual biological features. Therefore, reference values of SI/S ratios are very important for medical specialists who describe and diagnose locomotor system diseases. The aim of this paper is to develop a reference range of sacroiliac ratios. The innovativeness of this paper involves examining sacroiliac ratios for various age groups, in children and adult patients, taking their sex into consideration. The study comprised a group of 335 people with proper bone scintigraphy. These people were divided into children and patients aged ≥21. Children were divided into 4 age groups (1–5; 6–10; 11–15; 16–20) and adults into 6 age groups (21–30; 31–40; 41–50; 51–60; 61–70; ≥71). Sacroiliac ratios were calculated using the method of three rectangular region of interests located on the left and right sacroiliac joint and on the sacral bone. The sacroiliac ratio was calculated for both joints by dividing the average number of counts within a selected sacroiliac joint by the average number of counts within the sacral bone. SI/S borderline reference values covered the range of 1.18÷2.28 that was obtained for children aged ≤5 and for the group of 11–15-year-olds. Considerable discrepancies in the values of the coefficient for women and men were seen among 31–50-year-olds. Borderline reference results for the entire control group cover the range of 1.18 ±2

  12. Automated bone segmentation from large field of view 3D MR images of the hip joint

    International Nuclear Information System (INIS)

    Xia, Ying; Fripp, Jurgen; Chandra, Shekhar S; Schwarz, Raphael; Engstrom, Craig; Crozier, Stuart

    2013-01-01

    Accurate bone segmentation in the hip joint region from magnetic resonance (MR) images can provide quantitative data for examining pathoanatomical conditions such as femoroacetabular impingement through to varying stages of osteoarthritis to monitor bone and associated cartilage morphometry. We evaluate two state-of-the-art methods (multi-atlas and active shape model (ASM) approaches) on bilateral MR images for automatic 3D bone segmentation in the hip region (proximal femur and innominate bone). Bilateral MR images of the hip joints were acquired at 3T from 30 volunteers. Image sequences included water-excitation dual echo stead state (FOV 38.6 × 24.1 cm, matrix 576 × 360, thickness 0.61 mm) in all subjects and multi-echo data image combination (FOV 37.6 × 23.5 cm, matrix 576 × 360, thickness 0.70 mm) for a subset of eight subjects. Following manual segmentation of femoral (head–neck, proximal-shaft) and innominate (ilium+ischium+pubis) bone, automated bone segmentation proceeded via two approaches: (1) multi-atlas segmentation incorporating non-rigid registration and (2) an advanced ASM-based scheme. Mean inter- and intra-rater reliability Dice's similarity coefficients (DSC) for manual segmentation of femoral and innominate bone were (0.970, 0.963) and (0.971, 0.965). Compared with manual data, mean DSC values for femoral and innominate bone volumes using automated multi-atlas and ASM-based methods were (0.950, 0.922) and (0.946, 0.917), respectively. Both approaches delivered accurate (high DSC values) segmentation results; notably, ASM data were generated in substantially less computational time (12 min versus 10 h). Both automated algorithms provided accurate 3D bone volumetric descriptions for MR-based measures in the hip region. The highly computational efficient ASM-based approach is more likely suitable for future clinical applications such as extracting bone–cartilage interfaces for potential cartilage segmentation. (paper)

  13. Guided Bone Regeneration in Long-Bone Defects with a Structural Hydroxyapatite Graft and Collagen Membrane

    Science.gov (United States)

    2013-01-01

    Original Articles Guided Bone Regeneration in Long-Bone Defects with a Structural Hydroxyapatite Graft and Collagen Membrane Teja Guda, PhD,1,2 John...Joint Surg Br 90-B, 1617, 2008. 6. Carlo Reis, E.C., Borges AaPB, Araujo, M.V.F., Mendes, V.C., Guan, L., and Davies, J.E. Periodontal regeneration...Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials–biological foundation and preclinical evi- dence: a

  14. 99m technetium-MDP bone scintigraphy in evaluation of painful joint prosthesis

    International Nuclear Information System (INIS)

    Milosevic, D.; Jaukovic, M.; Jaukovic, Lj.; Ajdinovic, B.

    2004-01-01

    In addition of clinical evaluation and x-ray radiography, the diagnosis of a loose joint prosthesis is often made by nuclear medicine imaging techniques. Differentiation between loosening and infected prosthesis is important for better treatment of those patients. Aim: The aim of this study was to reevaluate the scintigraphic patterns in patients with painful hip of knee arthroplasty. Material and Method: From 1996. to 2003. forty patients aged 49-78 years were referred for evaluation of possible loosening/infection joint prosthesis: 36 pts with 39 total/ partial hip prosthesis, 1 pt with knee prosthesis and 3 pts with history of previously extracted hip prosthesis due to infection. Whole body acquisition had been performed with a single head gamma camera three hours after the injection of 740 MBq 99m Tc-MDP. Scans were classified as: positive for loosening if abnormal uptake was shown at the tip of the prosthesis; positive for infection if diffuse abnormal uptake was shown around the implant; negative and indeterminate scans. Scintigraphic findings were compared to clinical follow up, histology or cultures. Results: Positive findings were found in 17 bone scans strongly suggesting loosening in 10 cases, infection of prosthesis in 4 cases and both loosening/infection in 3 cases. Bone scintigraphy was normal in 11pts. Scans of three pts with previously extracted hip prosthesis and scheduled for reimplatation, showed inhomogeneously and mildly increased uptake in femur. Most of scans classified as indeterminate (n=12) showed slightly increased tracer uptake in region of acetabular roof, greater or lesser tho chanter, suggesting bone remodeling due to the presence of implant, rather than loosening. Conclusion: 99m Tc-MDP bone scintigraphy had a significant role in assessing the painful joint prosthesis. Complementary diagnostic procedures should be considered in indeterminate scintiscans. (authors)

  15. Bone scintigraphy as a process control with hemi-alloarthroplasty of the hip joint

    International Nuclear Information System (INIS)

    Shaltout, E.E.D.

    1983-01-01

    For the diagnostic of prosthesis complications in the treatment of femur fractures near the hip joint ('intermediate prostheses') 216 skeletal scintigrams with 99mTc MDP were made of 143 patients from 1977 to 1982, partially retrospective and partially prospective. The evaluation of the photoscan was achieved visually and photodensitometrically and divided into 10 intensity levels with the following results: 1. Increased activity concentration in the acetabulum is pathological (activated arthrosis); 2. Increased activity concentration-temporary or also continuous - in the trochanter region is pathological (loosening process); 3. Non-pathological metabolic activity as a result of the bone healing process may last longer than 1 year postoperatively; 4. Heterotopic ossification, non-fixed bone fragments and pseudoarthrosis cause continuous or newly appearing concentrations; 5. Skeletal scintigraphy is an important supplement to radiological diagnostic and a sensitive method for the recognition of metabolic activities in bone. It is recommended for progress control after hemi-alloarthrosculpture of the hip joint. (orig./TRV) [de

  16. The diagnostic value of monoclonal antibody scan (leucoscan) compared with 99mTc MDP bone scan and Ga 67 in diagnosing bone and joint infection

    International Nuclear Information System (INIS)

    Koukouraki, S.I.; Velidaki, A.; Prassopoulos, V.; Karkavitsas, N.; Vavouranakis, H.; Hatjipavlou, A.

    2002-01-01

    Full text: Nowadays different radiopharmaceuticals have been developed as 99mTc MDP, 67Ga citrate, 111In oxine- and 99mTc HMPAO labeled leucocytes for the accurate localization of bone/joint infection, but all of them have limitations that encouraged the search of new agents characterized from high and early uptake in infectious/inflammatory tissues, low toxicity and no accumulation in non inflamed tissues. The purpose of this study is to compare the diagnostic value of a 99mTc labeled antigranulocyte Fab' fragment (Leucoscan) with 99mTc MDP bone scan and 67 Ga. The monoclonal antibody, Leucoscan, is an IgG murine Fab' fragment directed against a NCA-90 epitope located on the surface of granulocytes. 45 patients with suspected bone and joint infection (18 total hip prosthesis, 4 knee prosthesis, 8 vertebral infection and 15 long bones) were included in this study. All patients underwent conventional Rx, bone scan, 67Ga scan and Leucoscan. Three phase 99mTc MDP bone scan and 67Ga scan were performed using standard procedures. For Leucoscan the antibody was labeled with 25 mCi of 99mTc and was infected intravenously over 30 seconds. Ten minutes planar images were taken 1 h and 2 hrs p.i using a GE Millennium γ camera provided with a LEGP collimator. Images were evaluated as score 1 (no abnormal uptake), score 2 (probably positive), score 3 (definitely infected) according the intensity of abnormally increased uptake. Results were compared with 99mTc MDP bone scan and 67Ga scans. The final diagnosis was given by the surgical verification with histopathology or culture. All 45 patients had pathologic proof of presence/absence of bone and joint infection. 36/45 were positive for bone or joint infection and 9/45 were negative.30/36 patients with surgically proven bone and joint infection had true positive Leucoscan, 26/36 had true positive MDP bone scan and 20/36 true positive 67Ga scan. Nine out of 9 patients with proven absence of inflammation had true negative

  17. ALPHA-CTX is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis

    Science.gov (United States)

    Huebner, Janet L; Bay-Jensen, Anne C; Huffman, Kim M; He, Yi; Leeming, Diana J; McDaniel, Gary E; Karsdal, Morten A; Kraus, Virginia B

    2014-01-01

    Objective To evaluate joint tissue remodeling, with urinary collagen biomarkers, uALPHA CTX and uCTXII, and their association with osteoarthritis (OA) severity, progression, and localized knee bone turnover. Methods Participants (N=149) with symptomatic and radiographic knee OA underwent fixed flexion knee radiography at baseline and 3 years, and late-phase bone scintigraphy of both knees at baseline, scored semi-quantitatively for osteophyte (OST) and joint space narrowing (JSN) severity and uptake intensity with scores summed across knees. Urinary concentrations of ALPHA CTX and CTXII were determined by ELISA. Immunohistochemistry of human OA knees was performed to localize the joint tissue origin of the biomarker epitopes. Results uALPHA CTX correlated strongly with intensity of bone scintigraphic uptake, and JSN and OST progression (risk ratio=13.2 and 3, respectively). uCTXII was strongly associated with intensity of bone scintigraphic uptake, with JSN and OST severity, and OA progression based on OST. uALPHA CTX localized primarily to high bone turnover areas in subchondral bone; CTXII localized to the bone-cartilage interface, the tidemark, and damaged articular cartilage. Conclusion Baseline uALPHA CTX, localized to high turnover areas of subchondral bone, was associated with dynamic bone turnover of knees signified by scintigraphy, and progression of both OST and JSN. uCTXII correlated with JSN and OST severity, and progression of OST. To our knowledge, this represents the first report of serological markers reflecting subchondral bone turnover. These collagen markers may be useful for non-invasive detection and quantification of active subchondral bone turnover and joint remodeling in knee OA. PMID:24909851

  18. The Plastic Nature of the Human Bone-Periodontal Ligament-Tooth Fibrous Joint

    Science.gov (United States)

    Ho, Sunita P.; Kurylo, Michael P.; Grandfield, Kathryn; Hurng, Jonathan; Herber, Ralf-Peter; Ryder, Mark I.; Altoe, Virginia; Aloni, Shaul; Feng, Jian Q. (Jerry); Webb, Samuel; Marshall, Grayson W.; Curtis, Donald; Andrews, Joy C.; Pianetta, Piero

    2014-01-01

    This study investigates bony protrusions within a narrowed periodontal ligament space (PDL-space) of a human bone-PDL-tooth fibrous joint by mapping structural, biochemical, and mechanical heterogeneity. Higher resolution structural characterization was achieved via complementary atomic force microscopy (AFM), nano transmission X-ray microscopy (nano-TXM), and micro tomography (Micro XCT™). Structural heterogeneity was correlated to biochemical and elemental composition, illustrated via histochemistry and microprobe X-ray fluorescence analysis (μ-XRF), and mechanical heterogeneity evaluated by AFM-based nanoindentation. Results demonstrated that the narrowed PDL-space was due to invasion of bundle bone (BB) into PDL-space. Protruded BB had a wider range with higher elastic modulus values (2-8 GPa) compared to lamellar bone (0.8-6 GPa), and increased quantities of Ca, P and Zn as revealed by μ-XRF. Interestingly, the hygroscopic 10-30 μm interface between protruded BB and lamellar bone exhibited higher X-ray attenuation similar to cement lines and lamellae within bone. Localization of the small leucine rich proteoglycan biglycan (BGN) responsible for mineralization was observed at the PDL-bone interface and around the osteocyte lacunae. Based on these results, it can be argued that the LB-BB interface was the original site of PDL attachment, and that the genesis of protruded BB identified as protrusions occurred as a result of shift in strain. We emphasize the importance of bony protrusions within the context of organ function and that additional study is warranted. PMID:24063947

  19. Successful Function-Preserving Therapy for Chondroblastoma of the Temporal Bone Involving the Temporomandibular Joint

    Directory of Open Access Journals (Sweden)

    Junkichi Yokoyama

    2011-02-01

    Full Text Available We present a case involving a late diagnosis of chondroblastoma of the temporal skull base involving the temporomandibular joint (TMJ. Following an initial misdiagnosis and unsuccessful treatment over a period of 5 years, the patient was referred to our department for further evaluation and possible surgical intervention for occlusal abnormalities, trismus, clicking of the TMJ, and hearing impairment. Based on preoperative immunochemical studies showing positive reaction of multinucleated giant cells for S-100 protein, the final diagnosis was chondroblastoma. The surgical approach – postauricular incision and total parotidectomy, with complete removal of the temporal bone, including the TMJ via the extended middle fossa – was successful in preserving facial nerves and diminishing clinical manifestations. This study highlights a misdiagnosed case in an effort to underline the importance of medical examinations and accurate differential diagnosis in cases involving any tumor mass in the temporal bone.

  20. Bones - joints - soft tissues II. 7. rev. ed. Knochen - Gelenke - Weichteile II

    Energy Technology Data Exchange (ETDEWEB)

    Dihlmann, W. (Roentgeninstitut, Allgemeines Krankenhaus Barmbek, Hamburg (Germany)); Frommhold, W. (Radiologische Klinik, Tuebingen Univ. (Germany)) (eds.)

    1991-01-01

    With the publication of the 2nd part to Volume VI, 'Bones - joints - soft tissues', the 7th edition of 'Diagnostic radiology in the hospital and medical practice' is complete. The advances made particularly during the past decade in the field of diagnostic radiology have made it neccesary for all the individual sections to be completely revised. Recently developed methods of imaging like sonography, computed tomography and magnetic resonance tomography are increasingly used as a replacement for or, at least, an adjunct to conventional X-ray procedures. Owing to the development and continuous refinement of related methods of intervention the gap between mere diagnostic applications and therapeutic uses of radiology could eventually be closed. The issues mainly discussed in this volume are bone fractures and healing, bone transplantation, osteopathy and osteoarthropathy, fibrous dyplasia or Albright's disease, Pagetoid osteitis, genetically transmitted constitutional disorders of the skeleton and soft tissue changes. While in the key sections on bone fractures and healing, osteopathy and osteoarthropathy as well as constitutional genetic disorders X-ray techniques are still described as the prevailing method of diagnosis, diseases of soft tissues now are much more commonly diagnosed using magnetic resonance imaging. (orig./MG) With 2248 figs., 59 tabs.

  1. [APPLICATION OF COMPRESSION MINI-SCREWS IN TREATMENT OF PATIENTS WITH INJURY OF ELBOW JOINT BONES].

    Science.gov (United States)

    Neverov, V A; Egorov, K S

    2015-01-01

    A case report presents the experience of application of compression pileateless mini-screws (Gerbert's screws) in treatment of intra-articular fractures, which formed the elbow joint (44 cases). There were performed 32 operations concerning fracture of head of radius, 10 operations on the occasion of fractures of distal section of the humerus and 2 operations on the coronoid process. Long-term treatment results were followed-up in 31 patients during more than 6 months. On basis of analysis of treatment results the authors made a conclusion that the application of mini-screws in case of bone fractures, which formed the elbow joint, allowed realization of stable osteosynthesis after anatomic reposition of articular surfaces, obtaining good anatomical and functional result and shortened the terms of patient's treatment.

  2. Changes of the radiological image of tuberculose of bones and joints

    International Nuclear Information System (INIS)

    Teerstra, H.J.; Taconis, W.K.

    1986-01-01

    Tuberculosis of bones and joints still occurs in the Netherlands, although with a low incidence. Most patients in this country are natives of Mediterranean countries and of Surinam. The classical radiological image appears to be changing in that multiple lesions occur more often, lesions occur in localizations rare for tuberculosis in patients of Dutch origin, very large abscesses are formed and in case of vertebral tuberculosis, extensive sclerosis develops with early osseous bridging and complete or partial preservation of disc spaces. The findings in 12 personal patients are described. (Auth.)

  3. ASCOT: Autologous Bone Marrow Stem Cell Use for Osteoarthritis of the Thumb—First Carpometacarpal Joint

    Science.gov (United States)

    Buckley, Christina; Sugrue, Conor; Carr, Emma; O’Reilly, Aine; O’Neill, Shane; Carroll, Sean M.

    2017-01-01

    Background: The first carpometacarpal joint (CMCJ) in the hand is a commonly affected joint by osteoarthritis. It causes significant thumb base pain, limiting functional capacity. Microfracturing and application of autologous stem cells has been performed on large joints such as the knee but has never been evaluated for use in the smaller joints in the hand. Our aim was to determine the potential benefit of microfracturing and autologous bone marrow stem cells for treatment of osteoarthritis of the first CMCJ in the hand. Methods: All inclusion criteria were satisfied. Preoperative assessment by the surgeon, physiotherapist, and occupational therapist was performed. The first CMCJ was microfractured and the Bone Marrow Stem Cells were applied directly. Postoperatively, the patients were followed up for 1 year. Results: Fifteen patients met inclusion criteria; however, 2 patients were excluded due to postoperative cellulitis and diagnosis of De Quervain's tenosynovitis. The mean scores of the 13-patient preoperative and 1 year follow-up assessments are visual analog score at rest of 3.23–1.69 (P = 0.0292), visual analog score on activity of 7.92–4.23 (P = 0.0019), range of motion 45.77o–55.15o (P = 0.0195), thumb opposition score 7.62–9.23 (P = 0.0154), Disability of the Arm, Shoulder and Hand score of 51.67–23.08 (P = 0.0065). Strength improved insignificantly from 4.7 kg preoperatively to 5.53 kg at 12 months (P = 0.1257). All patients had a positive Grind test preoperatively and a negative test after 12 months. Conclusions: This innovative pilot study is a new approach to osteoarthritis of the thumb. PMID:29062653

  4. Comparative Analysis of Bone Structural Parameters Reveals Subchondral Cortical Plate Resorption and Increased Trabecular Bone Remodeling in Human Facet Joint Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Cordula Netzer

    2018-03-01

    Full Text Available Facet joint osteoarthritis is a prominent feature of degenerative spine disorders, highly prevalent in ageing populations, and considered a major cause for chronic lower back pain. Since there is no targeted pharmacological therapy, clinical management of disease includes analgesic or surgical treatment. The specific cellular, molecular, and structural changes underpinning facet joint osteoarthritis remain largely elusive. The aim of this study was to determine osteoarthritis-related structural alterations in cortical and trabecular subchondral bone compartments. To this end, we conducted comparative micro computed tomography analysis in healthy (n = 15 and osteoarthritic (n = 22 lumbar facet joints. In osteoarthritic joints, subchondral cortical plate thickness and porosity were significantly reduced. The trabecular compartment displayed a 42 percent increase in bone volume fraction due to an increase in trabecular number, but not trabecular thickness. Bone structural alterations were associated with radiological osteoarthritis severity, mildly age-dependent but not gender-dependent. There was a lack of association between structural parameters of cortical and trabecular compartments in healthy and osteoarthritic specimens. The specific structural alterations suggest elevated subchondral bone resorption and turnover as a potential treatment target in facet joint osteoarthritis.

  5. Single Neurosurgeon Operative Experience at Craig Joint Theater Hospital During the Afghanistan Surge (November 2010 to April 2011), Part II: Humanitarian Cases.

    Science.gov (United States)

    Steele, John Joseph

    2017-01-01

    The Afghanistan Surge saw NATO troops working with their Afghan partners to remove Taliban governance and replace it with a more democratic model. As part of this endeavor, medical support for both trauma and humanitarian cases was needed. Identify and discuss disease trends to better prepare for future combat medical treatments. Retrospective review of operative experience from a neurosurgeon from November 2010 to April 2011. 63 cases were performed on 20 NATO and 43 Afghan patients. Combat-related neurotrauma represented 73% (46/63) of cases and humanitarian cases represented the remainder. The most common diseases among humanitarian cases were benign tumors (29%, 5/17), cranioplasty (23%, 4/17), obstructive hydrocephalus (11%, 2/17), nonobstructive hydrocephalus (11%, 2/17), hemifacial spasm (11%, 2/17), and cerebral angiography (11%, 2/17). There was 1 death from ventriculitis for a complication rate of 6%. In select well-nourished, patients with minimal risk of needing tracheostomy, humanitarian neurosurgery can be safely performed in theater with a complication rate (6%) no worse than patients operated on in the United States. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.

  6. Prevalence of computed tomographic subchondral bone lesions in the scapulohumeral joint of 32 immature dogs with thoracic limb lameness.

    Science.gov (United States)

    Lande, Rachel; Reese, Shona L; Cuddy, Laura C; Berry, Clifford R; Pozzi, Antonio

    2014-01-01

    Osteochondrosis is a common developmental abnormality affecting the subchondral bone of immature, large breed dogs. The purpose of this retrospective study was to describe CT lesions detected in scapulohumeral joints of 32 immature dogs undergoing CT for thoracic limb lameness. Eight dogs (14 scapulohumeral joints) had arthroscopy following imaging. Thirteen dogs (19 scapulohumeral joints) were found to have CT lesions, including 10 dogs (16 scapulohumeral joints) with subchondral bone lesions and 3 dogs with enthesopathy of the supraspinatus tendon. In one dog, subchondral bone lesions appeared as large oval defects within the mid-aspect of the glenoid cavities, bilaterally. These lesions resembled osseous cyst-like lesions commonly identified in the horse. This is the first report of such a presentation of a subchondral bone lesion in the glenoid cavity of a dog. In all dogs, small, focal, round or linear lucent defects were visible within the cortical bone at the junction of the greater tubercle and intertubercular groove. These structures were thought to represent vascular channels. Findings from this study support the use of CT as an adjunct modality for the identification and characterization of scapulohumeral subchondral bone lesions in immature dogs with thoracic limb lameness. © 2013 American College of Veterinary Radiology.

  7. A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis.

    Science.gov (United States)

    Barr, Andrew J; Campbell, T Mark; Hopkinson, Devan; Kingsbury, Sarah R; Bowes, Mike A; Conaghan, Philip G

    2015-08-25

    Bone is an integral part of the osteoarthritis (OA) process. We conducted a systematic literature review in order to understand the relationship between non-conventional radiographic imaging of subchondral bone, pain, structural pathology and joint replacement in peripheral joint OA. A search of the Medline, EMBASE and Cochrane library databases was performed for original articles reporting association between non-conventional radiographic imaging-assessed subchondral bone pathologies and joint replacement, pain or structural progression in knee, hip, hand, ankle and foot OA. Each association was qualitatively characterised by a synthesis of the data from each analysis based upon study design, adequacy of covariate adjustment and quality scoring. In total 2456 abstracts were screened and 139 papers were included (70 cross-sectional, 71 longitudinal analyses; 116 knee, 15 hip, six hand, two ankle and involved 113 MRI, eight DXA, four CT, eight scintigraphic and eight 2D shape analyses). BMLs, osteophytes and bone shape were independently associated with structural progression or joint replacement. BMLs and bone shape were independently associated with longitudinal change in pain and incident frequent knee pain respectively. Subchondral bone features have independent associations with structural progression, pain and joint replacement in peripheral OA in the hip and hand but especially in the knee. For peripheral OA sites other than the knee, there are fewer associations and independent associations of bone pathologies with these important OA outcomes which may reflect fewer studies; for example the foot and ankle were poorly studied. Subchondral OA bone appears to be a relevant therapeutic target. PROSPERO registration number: CRD 42013005009.

  8. Clinical application of 99mTc-HMPAO labeled leucocytes imaging in detecting bone joint infection

    International Nuclear Information System (INIS)

    Li Biao; Barthe, N.; Basse-Cathalinat, B.

    1995-01-01

    99m Tc-MDP scintigraphy and 99m Tc-HMPAO-leucocytes imaging were performed in twenty five patients with clinically suspected bone joint infection. All of the 25 cases were confirmed by surgery, microbiological and histologic examinations. Among them 21 cases were definitively diagnosed as infections, while 3 cases were non-infection. The results of 99m Tc-MDP scintigraphy showed that all of 25 cases demonstrated anomalous accumulation of radioactivity in the clinically suspected infections sites, while in 99m Tc-HMPAO-leucocytes imaging, concentrated radioactivity in proved infectious sites was observed in 19 cases, non-anomalous radioactivity found in 4 cases of non-infectious sites, but there were 2 cases false negative with long term antibiotics treatment, none of the case was false positive. Thereby a sensitivity of the labelled leucocytes imaging of 90.5%, a specificity of 100%, and a accuracy of about 92% were found. Present research work concluded that 99m Tc-HMPAO labelled leucocytes imaging provided a non-invasive, effective, and reliable diagnostic method in detecting patients with clinically suspected bone joint infection and afforded strong evidence for effective therapy

  9. Bone bruise in magnetic resonance imaging strongly correlates with the production of joint effusion and with knee osteoarthritis

    International Nuclear Information System (INIS)

    Oda, Hiromi; Igarashi, Mitsuo; Sase, Hiroshi; Sase, Takeshi; Yamamoto, Seizo

    2008-01-01

    The findings of magnetic resonance imaging (MRI) have not been studied systematically in patients with osteoarthritis (OA). The objective here was to compare MRI findings with radiological findings in patients with knee pain and to identify factors that influence the progression of OA of the knee. Of 212 patients with knee pain and MRI of the knee joint, 161 patients were selected for the study after exclusion of cases of trauma and other arthritides. MRI was used to evaluate the presence and degree of bone bruise, hydrarthrosis, and injuries to the cruciate ligament and meniscus. Bone bruise was classified into four types, and hydrarthrosis into four grades. Radiologically, OA progression in the femorotibial and patellofemoral joints was analyzed according to the Kellgren-Lawrence classification. Age was divided into four groups based on distribution quartiles. Logistic regression analysis and a generalized linear model with Poisson regression were used to analyze correlations among these factors. Bone bruise was present in 87 cases, hydrarthrosis in 100, cruciate ligament injury in 20, and meniscus injury in 98. The presence of bone bruise was not related to age, cruciate ligament injury, meniscus injury, nor to OA of the patellofemoral joint, but was related to hydrarthrosis and to OA of the femorotibial joint. Femorotibial OA was much more strongly associated with bone bruise than with hydrarthrosis. Furthermore, analyzing the relation between the types of bone bruise and the degree of hydrarthrosis using a generalized linear model with Poisson regression, there was a positive correlation between the grade of bone bruise and the amount of hydrarthrosis. A factor associated with the degree of osteoarthritis of the knee is bone bruise observed on MRI. The degree of hydrarthrosis is related to the grade of bone bruise, but is not linked to the degree of osteoarthritis. (author)

  10. Radiographic examination of the hoof joint and navicular bone for the reason of prepurchase examination of the horse

    International Nuclear Information System (INIS)

    Zert, Z.; Sterc, J.; Bartunkova, H.

    2002-01-01

    The optimal radiographic examination of the equine hoofjoint and navicular bone requires lateral, dorsopalmar and oblique proximodistal-palmarodistal (tangential) projections. The radiographic method used and the choice of the material are crucial elements for the image quality and the usefulness of the examination. It is not always easy to obtain precise lateral view, which can help in detection of changes on the flexor surface, disclose interior structure of navicular bone, as well as facilitates observation of dorsal aspect of the hoof joint. The dorsopalmar projection can provide nearly complete information about the borders of the navicular bone and its relationship to the adjacent structures. The 55 deg PP-PD projection reveals once again flexor surface and the interior structure of navicular bone without any superposition. This projection allows demonstration of early structural changes (namely sclerosis) in the transitional zone of the facies flexora bone plate and the navicular spongious bone

  11. Bone and joint infections by Mucorales, Scedosporium, Fusarium and even rarer fungi.

    Science.gov (United States)

    Koehler, Philipp; Tacke, Daniela; Cornely, Oliver A

    2016-01-01

    Mucorales, Scedosporium and Fusarium species are rarely considered as cause for bone and joint infections. However, these moulds are emerging as important fungal pathogens in immunocompromised and immunocompetent patients. Typical pre-disposing host conditions are immunosuppression and diabetes. Most common causative pathogens are Mucorales followed by Scedosporium and Fusarium. Acremonium and Phialemonium species are rare but some case reports exist. MRI is the gold standard imaging technique. Tissue specimens obtained as aspirates, imaging guided biopsy or open surgery need mycological and histopathological work-up for genus and species identification. Multimodal treatment strategies combine surgical debridement, drainage of joints or abscesses, removal of infected prosthetic joints and systemic antifungals. The treatment of mucormycosis is polyene based and may be combined with either posaconazole or - in rare cases - caspofungin. As Scedosporium species are intrinsically resistant to polyenes and azoles show absence of in vitro activity, voriconazole plus synergistic treatment regimens become the therapeutic standard. In fusariosis, fungal susceptibility is virtually impossible to predict, so that combination treatment of voriconazole and lipid-based amphotericin B should be the first-line strategy while susceptibility results are pending. In the absence of randomized controlled trials, infections due to the above moulds should be registered, e.g. in the registries of the European Confederation of Medical Mycology (ECMM).

  12. Storm surge climatology report

    OpenAIRE

    Horsburgh, Kevin; Williams, Joanne; Cussack, Caroline

    2017-01-01

    Any increase in flood frequency or severity due to sea level rise or changes in storminess would adversely impact society. It is crucial to understand the physical drivers of extreme storm surges to have confidence in the datasets used for extreme sea level statistics. We will refine and improve methods to the estimation of extreme sea levels around Europe and more widely. We will do so by developing a comprehensive world picture of storm surge distribution (including extremes) for both tropi...

  13. Association between disk position and degenerative bone changes of the temporomandibular joints: an imaging study in subjects with TMD.

    Science.gov (United States)

    Cortés, Daniel; Sylvester, Daniel Cortés; Exss, Eduardo; Marholz, Carlos; Millas, Rodrigo; Moncada, Gustavo

    2011-04-01

    The aim of this study was to determine the frequency and relationship between disk position and degenerative bone changes in the temporomandibular joints (TMJ), in subjects with internal derangement (ID). MRI and CT scans of 180 subjects with temporomandibular disorders (TMD) were studied. Different image parameters or characteristics were observed, such as disk position, joint effusion, condyle movement, degenerative bone changes (flattened, cortical erosions and irregularities), osteophytes, subchondral cysts and idiopathic condyle resorption. The present study concluded that there is a significant association between disk displacement without reduction and degenerative bone changes in patients with TMD. The study also found a high probability of degenerative bone changes when disk displacement without reduction is present. No association was found between TMD and condyle range of motion, joint effusion and/or degenerative bone changes. The following were the most frequent morphological changes observed: flattening of the anterior surface of the condyle; followed by erosions and irregularities of the joint surfaces; flattening of the articular surface of the temporal eminence, subchondral cysts, osteophytes; and idiopathic condyle resorption, in decreasing order.

  14. Knee joint preservation surgery in osteosarcoma using tumour-bearing bone treated with liquid nitrogen.

    Science.gov (United States)

    Higuchi, Takashi; Yamamoto, Norio; Nishida, Hideji; Hayashi, Katsuhiro; Takeuchi, Akihiko; Kimura, Hiroaki; Miwa, Shinji; Inatani, Hiroyuki; Shimozaki, Shingo; Kato, Takashi; Aoki, Yu; Abe, Kensaku; Taniguchi, Yuta; Tsuchiya, Hiroyuki

    2017-10-01

    To preserve the joint structure in order to maintain good limb function in patients with osteosarcoma, we perform epiphyseal or metaphyseal osteotomy and reconstruction using frozen autografts that contain a tumour treated with liquid nitrogen. There are two methods of using liquid nitrogen-treated autografts: the free-freezing method and the pedicle-freezing method. The purpose of this study was to evaluate the results of intentional joint-preserving reconstruction using the free-freezing method and the pedicle-freezing method in patients with osteosarcoma. Between 2006 and 2014, we performed joint-preserving surgery (12 with the free-freezing method and six with the pedicle freezing method) to treat 18 cases of osteosarcoma (12 distal femurs and six proximal tibias) in patients who had achieved a good response to neoadjuvant chemotherapy. Among the 18 patients (nine boys and nine girls) who had a mean age of 11.6 years, 13 remained continuously disease-free, three showed no evidence of disease, one was alive with the disease, and one died from the disease. Functional outcomes were assessed as excellent in 15 patients and poor in three, with a mean follow-up period of 46.1 months. The mean Musculoskeletal Tumour Society (MSTS) score was 90.2%. Except for one patient who underwent amputation, all patients could bend their knee through >90° flexion, and nine achieved full ROM. All but two patients could walk without aid, and 11 were able to run normally throughout the follow-up period. No intraoperative complications were observed, such as surrounding soft-tissue damage, neurovascular injury, or recurrence from frozen bone. Joint-preserving reconstruction using frozen autografts yielded excellent function in patients with osteosarcoma.

  15. Long-Term Symptoms Onset and Heterotopic Bone Formation around a Total Temporomandibular Joint Prosthesis: a Case Report

    Directory of Open Access Journals (Sweden)

    Luca Guarda-Nardini

    2014-04-01

    Full Text Available Background: The literature on total alloplastic temporomandibular joint (TMJ reconstructions is encouraging, and studies on total alloplastic TMJ replacements outcomes showed acceptable improvements in terms of both pain levels and jaw function. Nevertheless, some adverse events, such as heterotopic bone formation around the implanted prosthesis, may occur. In consideration of that, the present manuscript describes a case of heterotopic bone formation around a total temporomandibular joint prosthesis, which occurred several years after the implant. Methods: The present manuscript describes a case of heterotopic bone formation around a total TMJ prosthesis, which occurred several years after the implant in patients, who previously underwent multiple failed TMJ surgeries. Results: Ten years after the surgical TMJ replacement to solve an ankylotic bone block, the patient came to our attention again referring a progressive limitation in mouth opening. A computerized tomography showed evidence of marked heterotopic bone formation in the medial aspects of the joint, where a new-born ankylotic block occupied most part of the gap created by resecting the coronoid process at the time of the TMJ prosthesis insertion. Conclusions: Despite this adverse event has been sometimes described in the literature, this is the first case in which its occurrence happened several years after the temporomandibular joint replacement. It can be suggested that an accurate assessment of pre-operative risk factors for re-ankylosis (e.g., patients with multiple failed temporomandibular joint surgeries and within-intervention prevention (e.g., strategies to keep the bone interfaces around the implant separated should be better standardized and define in future studies.

  16. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report

    NARCIS (Netherlands)

    Kager, L.; Whelan, J.; Dirksen, U.; Hassan, B.; Anninga, J.; Bennister, L.; Bovee, J.V.; Brennan, B.; Broto, J.M.; Brugieres, L.; Cleton-Jansen, A.M.; Copland, C.; Dutour, A.; Fagioli, F.; Ferrari, S.; Fiocco, M.; Fleuren, E.D.; Gaspar, N.; Gelderblom, H.; Gerrand, C.; Gerss, J.; Gonzato, O.; Graaf, W.T. van der; Hecker-Nolting, S.; Herrero-Martin, D.; Klco-Brosius, S.; Kovar, H.; Ladenstein, R.; Lancia, C.; Ledeley, M.C.; McCabe, M.G.; Metzler, M.; Myklebost, O.; Nathrath, M.; Picci, P.; Potratz, J.; Redini, F.; Richter, G.H.; Reinke, D.; Rutkowski, P.; Scotlandi, K.; Strauss, S.; Thomas, D; Tirado, O.M.; Tirode, F.; Vassal, G.; Bielack, S.S.

    2016-01-01

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children's Cancer Research Institute in Vienna, Austria on September 24-25, 2015. The joint bone sarcoma network meetings bring together

  17. How can we assess the burden of muscle, bone and joint conditions in rural Botswana

    DEFF Research Database (Denmark)

    Hondras, Maria; Myburgh, Corrie; Hartvigsen, Jan

    2015-01-01

    , organisational and clinical characteristics for the burden of living with and caring for people living with musculoskeletal conditions in rural Botswana. In this paper, we describe the community context, theoretical framework, and research methods to address the project aim with a qualitative study. METHODS......-participant and participant observations, and informal and in-depth interviews with villagers and healthcare providers. Villager interviews were typically conducted in Setswana with an interpreter. Audio recordings were transcribed verbatim in the language spoken with Setswana contextually translated into English. Computer......- and middle-income countries in Africa. Since 2011, World Spine Care, a nongovernmental organisation, has collaborated with the Botswana Ministry of Health to open spine care centres and to conduct research. The broad aim of the Muscle, Bone and Joint (MuBoJo) research project is to examine the sociocultural...

  18. Diagnosis of infected bone and joint diseases with 99mTc-HM-PAO labeled leukocytes

    International Nuclear Information System (INIS)

    Kanegae, Kakuko; Itoh, Kazuo; Tsukamoto, Eriko; Nagao, Kazuhiko; Nakada, Kunihiro; Hurudate, Masayori

    1992-01-01

    The usefulness of 99m Tc-hexamethylpropylene amine oxime (HM-PAO) labeled leukocytes scans was studied in 15 patients with suspected infection of the bone and joints. All spot images of lesions were obtained 4 and 24 hours after injection of 70.3-236.8 MBq (a mean, 149.5 MBq). 99m Tc-HM-PAO leukocytes scans were positive in 5 patients, negative in 8, and equivocal in 2. It had a sensitivity of 83% (5/6), specificity of 100% (6/6), and accuracy of 93% (14/15) for diagnosing infections. Equivocal uptake, seen on the 4-hr image in 2 patients, became negative on the 24-hr image. In view of ready availability and simple labeling procedure, 99m Tc-HM-PAO labeled leukocytes scans can be used as one of the specific diagnostic procedures for infections. (N.K.)

  19. A joint analysis of wave and surge conditions for past and present extrem events in the south-western Baltic Sea

    Science.gov (United States)

    Groll, Nikolaus; Gaslikova, Lidia

    2017-04-01

    Extreme marine events in the south-western Baltic Sea like the historic storm in 1872 are rare, but have large impacts on human safety and coastal infrastructure. The aforementioned extreme storm event of 1872 and has cost over 250 human lives, left severely damaged infrastructure and caused land loss due to coastal erosion. Recent extreme events also result in drastic impacts to coastal regions. Using results from numerical wave and hydrodynamic model simulations we will present a joint analysis of wave and water level conditions for selected extreme events. For the historic event the numerical models have been forced by reconstructed wind and pressure fields from pressure readings. Simulated atmospheric conditions from reanalysis have been used for the more recent events. The height of the water level due to the possible previous inflow of water masses in the Baltic Sea basin, as well as possible seiches and swell effects have been incorporated in the simulations. We will discuss similarities and differences between the historic and the more recent marine hazard events.

  20. Imaging of bone spavin. A radiographic and scintigraphic study of degenerative joint disease in the distal tarsus in Icelandic horses

    International Nuclear Information System (INIS)

    Eksell, P.

    2000-01-01

    Radiography and scintigraphy are commonly used for the diagnosis of skeletal disorders in horses. Icelandic Horses have a high prevalence of degenerative joint disease of the distal tarsus, generally known as bone spavin (BS). The purpose of this study was to evaluate and develop the use of radiography and scintigraphy for the detection of BS in Icelandic Horses

  1. [Effect of bone cement application on the incidence of deep vein thrombosis in major joint arthroplasties].

    Science.gov (United States)

    Aslan, Ahmet; Ağar, Emre; Aydoğan, Nevres Hürriyet; Atay, Tolga; Baydar, Metin Lütfi; Kırdemir, Vecihi; Ozden, Ahmet

    2011-12-01

    In this study, we have investigated whether the application of bone cement has an effect on the frequency of deep vein thrombosis (DVT) in major joint arthroplasties (MJA). A total of 95 MJA cases meeting the inclusion criteria of this study between January 2004 and January 2005 were divided into cemented and cementless groups. For prophylaxis, all patients were given low molecular weight heparin (LMWH). The patients were scanned for DVT preoperatively and on the postoperative 12(th) day by color Doppler ultrasonography. In hip arthroplasties, in knee arthroplasties and in general, DVT was seen more frequently in cemented group, however, there was no statistically significant difference between groups in the frequency of DVT (p=0.549, p=0.749 and p=0.462, respectively). Also, there was no significant difference between the results of the different LMWH groups (p=0.616). The results of this study shows that bone cement application in MJAs such as hip or knee arthroplasties has no significant effect on the frequency of DVT.

  2. Microbiology and management of joint and bone infections due to anaerobic bacteria.

    Science.gov (United States)

    Brook, Itzhak

    2008-03-01

    To describes the microbiology, diagnosis, and management of septic arthritis and osteomyelitis due to anaerobic bacteria. The predominant anaerobes in arthritis are anaerobic Gram-negative bacilli (AGNB) including the Bacteroides fragilis group, Fusobacterium spp., Peptostreptococcus spp., and Propionibacterium acnes. Infection with P. acnes is associated with a prosthetic joint, previous surgery, and trauma. B. fragilis group is associated with distant infection, Clostridium spp. with trauma, and Fusobacterium spp. with oropharyngeal infection. Most cases of anaerobic arthritis, in contrast to anaerobic osteomyelitis, involved a single isolate, and most cases are secondary to hematogenous spread. The predominant anaerobes in osteomyelitis are Bacteroides, Peptostreptococcus, Fusobacterium, and Clostridium spp. as well as P. acnes. Conditions predisposing to bone infections are vascular disease, bites, contiguous infection, peripheral neuropathy, hematogenous spread, and trauma. Pigmented Prevotella and Porphyromonas spp. are mostly isolated in skull and bite infections, members of the B. fragilis group in hand and feet infections, and Fusobacterium spp. in skull, bite, and hematogenous long bone infections. Many patients with osteomyelitis due to anaerobic bacteria have evidence of an anaerobic infection elsewhere in the body that is the source of the organisms involved in the osteomyelitis. Treatment of arthritis and osteomyelitis involving anaerobic bacteria includes symptomatic therapy, immobilization in some cases, adequate drainage of purulent material, and antibiotic therapy effective against these organisms. Anaerobic bacteria can cause septic arthritis and osteomyelitis. Correct diagnosis and appropriate therapy are important contributor to successful outcome.

  3. [Effect of tumour necrosis factor α blockade on bone metabolism in chronic inflammatory joint diseases].

    Science.gov (United States)

    Aguilar Del Rey, Francisco Javier; García Portales, Rosa; Haro Liger, Manuel; Rodríguez Andreu, José; Casals Sánchez, José Luis; Pérez González, Rita

    2016-07-15

    To evaluate the effect of anti-TNF treatments on bone mineral density (BMD), bone remodelling markers (BRM) and receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) in patients with chronic inflammatory joint diseases. A longitudinal prospective study was performed under clinical practice conditions on 31 patients diagnosed of rheumatoid arthritis, psoriatic arthropathy and ankylosing spondylitis who had received treatment with anti-TNF alpha drugs for one year. BMD, OPG and RANKL soluble form (sRANKL) were studied at the onset and end of the study. During the study (0, 3, 6, 9 and 12 month), disease activity (SDAI, BASDAI and CRP), functional capacity (HAQ, BASFI), BRM and vitamin D were studied. BMD was not modified after one year of treatment. The patients who took corticosteroids had a mean bone mass loss of 3% in the lumbar spine (±1.6, P=.02). In regards to the BRM, did not experience significant changes over the course of the study. Disease activity, both SDAI (P=.002) and BASDAI (P=.002), decreased. OPG was maintained without changes during the year of treatment while both the sRANKL (0.28±0.22, P=.013) and sRANKL/OPG ratio significantly decreased (0.04±0.03, P=.031). The patients being treated with anti-TNF did not present with a significant loss of DMO during the study (one year), at the same time experiencing an improvement in disease activity. This protection has been clearer in the responding patients. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  4. New total ossicular replacement prostheses with a resilient joint: experimental data from human temporal bones.

    Science.gov (United States)

    Arechvo, Irina; Bornitz, Matthias; Lasurashvili, Nikoloz; Zahnert, Thomas; Beleites, Thomas

    2012-01-01

    New flexible total ossicular prostheses with an integrated microjoint can compensate for large static displacements in the reconstructed ossicular chain. When properly designed, they can mimic the function of the joints of the intact chain and ensure good vibration transfer in both straight and bent conditions. Prosthesis dislocations and extrusions are frequently observed after middle ear surgery. They are mainly related to the altered distance between the coupling points because of large static eardrum displacements. The new prostheses consist of 2 titanium shafts, which are incorporated into a silicone body. The sound transfer function and stapes footplate displacement at static loads were evaluated in human temporal bones after ossicular reconstruction using prostheses with 2 different silicones with different hardness values. The stiffness and bending characteristics of the prostheses were investigated with a quasi-static load. The sound transfer properties of the middle ears with the prostheses inserted under uncompressed conditions were comparable with those of ears with intact ossicular chains. The implant with the soft silicone had improved acoustic transfer characteristics over the implant with the hard silicone in a compressed state. In the quasi-static experiments, the minimum medial footplate displacement was found with the same implant. The bending characteristics depended on the silicone stiffness and correlated closely with the point and angle of the load incidence. The titanium prostheses with a resilient joint that were investigated in this study had good sound transfer characteristics under optimal conditions as well as in a compressed state. As a result of joint bending, the implants compensate for the small changes in length of the ossicular chain that occur under varying middle ear pressure. The implants require a stable support at the stapes footplate to function properly.

  5. Assessing joint effusion and bone changes of the head of the mandible in MR images of symptomatic patients

    Directory of Open Access Journals (Sweden)

    Jefferson Xavier de Oliveira

    2013-02-01

    Full Text Available The aim of the present study was to investigate the relationship between degenerative bone changes of the head of the mandible and the presence of joint effusion (JE. This study was based on sagittal magnetic resonance imaging (MRI reports of 148 temporomandibular joints (TMJs of 74 patients complaining of pain and/or dysfunction in the TMJ area. The mandible heads were surveyed for osteoarthritis characteristics, which were classified as osteophytosis, sclerosis or erosion. The presence of JE was checked whenever high signal intensity was observed in the articular space. The results evidenced the presence of bone changes in 30% of the sample. Osteophytes and erosions were the changes most commonly observed. JE was reported in 10% of TMJs. The results from the statistical tests revealed that bone changes in the head of the mandible are associated with the presence of JE.

  6. Anatomic relationships of the distal and proximal radioulnar joints articulating surface areas, and of the radius and ulna bone volumes – implications for biomechanical studies of the distal and proximal radioulnar joints and forearm bones

    Directory of Open Access Journals (Sweden)

    Paul S C Malone

    2016-07-01

    Full Text Available BackgroundPrevious work from this laboratory has evidenced the biomechanical role of forearm osseoligamentous structures in load transfer of applied forces. It has shown that transmitted forces across the distal radioulnar joint (DRUJ and proximal radioulnar joint (PRUJ are similar though not identical under axial loading conditions. The purpose of the study was to assess the articulating surface areas of the radioulnar joints and the volumes of the forearm bones addressing the hypothesis that there may be anatomic adaptations that reflect the biomechanical function of the integrated forearm unit.MethodsThe articulating surface areas of PRUJ and DRUJ were assessed using a laser scanner in 24 cadaver forearms. The articulating joint surfaces were additionally delineated from standardized photographs assessed by three observers. The surface areas of matched pairs of joints were compared on the null hypothesis that these were the same within a given forearm specimen. An additional 44 pairs of matched forearm bone volumes were measured using water displacement technique and again compared through statistical analysis (paired sample t-test, and Bland Altman analysis.ResultsThe findings of this study are that the articulating surface areas of the DRUJ and PRUJ as well as the bone volumes are significantly different and yet strongly correlated. The paired sample t-test showed a significant difference between the surface areas of the DRUJ and PRUJ (p<0.05. The PRUJ articulating surface area was marginally larger than the DRUJ with a PRUJ : DRUJ ratio of 1.02. Paired sample t-test showed a significant difference between the two bone volumes (p<0.01 with a radius to ulna bone volume ratio of 0.81. When the olecranon was disregarded, radius volume was on average 4% greater than ulna volume.ConclusionsThis study demonstrated defines the anatomical relationships between the two forearm bones and their articulating joints when matched for specimen. The data

  7. Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

    Science.gov (United States)

    Pickett, Julie E; Thompson, John M; Sadowska, Agnieszka; Tkaczyk, Christine; Sellman, Bret R; Minola, Andrea; Corti, Davide; Lanzavecchia, Antonio; Miller, Lloyd S; Thorek, Daniel Lj

    2018-01-01

    Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immunoPET imaging in an in vivo mouse model of prosthetic joint infection (PJI). In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography (PET) with [ 18 F]FDG and [ 18 F]NaF as well as X-ray computed tomography (CT), before being evaluated with the zirconium-89-labeled antibody specific for LTA ([ 89 Zr]SAC55). The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. Results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater ( P  infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [ 89 Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI.

  8. Persistent bone marrow edema after osteochondral autograft transplantation in the knee joint

    International Nuclear Information System (INIS)

    Nemec, Stefan Franz; Marlovits, Stefan; Trattnig, Siegfried

    2009-01-01

    Background and objective: The assessment of bone marrow edema-like signal intensity in magnetic resonance imaging (MRI) in patients after osteochondral autograft transplantation (OCT) in the knee joint is a parameter of yet indefinite value. This study determines the prevalence of persistent edema-like signal intensity in OCT patients and evaluates the correlation between edema and morphological imaging findings of the graft and clinical pain symptoms. Materials and methods: In this longitudinal observational study, 10 patients after OCT were followed by MRI prospectively 1 month, 3 months, 6 months, 12 months, and 24 months post-operatively. All MR examinations were performed on a 1.0 T MR unit with the same protocol using a modified scoring system (magnetic resonance observation of cartilage repair tissue-MOCART) for evaluation. Edema-like signal intensity in and beneath the osteochondral graft was assessed in its prevalence and graded using a coronal short tau inversion recovery fast spin echo (STIR-FSE) sequence: grade 1, normal; grade 2, moderate (diameter 2 cm). The finding of edema-like signal intensity was correlated with graded parameters describing the morphology of the repair tissue assessed in a sagittal dual FSE sequence including: (a) surface of repair tissue: grade 1, intact; grade 2, damaged. (b) Cartilage interface: grade 1, complete; grade 2, incomplete. (c) Bone interface: grade 1, complete; grade 2, delamination. The finding of edema-like signal intensity was also correlated with the KOOS pain score assessing knee pain after 12 months. Results: Initially, after 1 month the prevalence of edema-like signal intensity was 70% (7/10 patients) and finally after 24 months 60% (6/10 patients). We found no significant relationship between the prevalence and degree of edema-like signal intensity and parameters describing the morphology of the repair tissue. Also the clinical pain score did not show significant correlation with edema. Conclusion

  9. Skeletal muscle contraction in protecting joints and bones by absorbing mechanical impacts

    Science.gov (United States)

    Rudenko, O. V.; Tsyuryupa, S.; Sarvazyan, A.

    2016-09-01

    We have previously hypothesized that the dissipation of mechanical energy of external impact is a fundamental function of skeletal muscle in addition to its primary function to convert chemical energy into mechanical energy. In this paper, a mathematical justification of this hypothesis is presented. First, a simple mechanical model, in which the muscle is considered as a simple Hookean spring, is considered. This analysis serves as an introduction to the consideration of a biomechanical model taking into account the molecular mechanism of muscle contraction, kinetics of myosin bridges, sarcomere dynamics, and tension of muscle fibers. It is shown that a muscle behaves like a nonlinear and adaptive spring tempering the force of impact and increasing the duration of the collision. The temporal profiles of muscle reaction to the impact as functions of the levels of muscle contraction, durations of the impact front, and the time constants of myosin bridges closing, are obtained. The absorption of mechanical shock energy is achieved due to the increased viscoelasticity of the contracting skeletal muscle. Controlling the contraction level allows for the optimization of the stiffness and viscosity of the muscle necessary for the protection of the joints and bones.

  10. Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair

    Science.gov (United States)

    Fellows, Christopher R.; Matta, Csaba; Zakany, Roza; Khan, Ilyas M.; Mobasheri, Ali

    2016-01-01

    Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion, and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum, and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities, and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple “one size fits all,” but more likely an array of solutions that need to be applied systematically to achieve regeneration of a biomechanically competent repair tissue. PMID:28066501

  11. Adipose, Bone Marrow and Synovial Joint-derived Mesenchymal Stem Cells for Cartilage Repair

    Directory of Open Access Journals (Sweden)

    Christopher Fellows

    2016-12-01

    Full Text Available Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple ‘one size fits all’, but more likely an array of solutions that need to applied systematically to achieve regeneration of a biomechanically competent repair tissue.

  12. Decrease in local volumetric bone mineral density (vBMD) in osteoarthritic joints is associated with the increase in cartilage damage: a pQCT study

    Science.gov (United States)

    Tamaddon, Maryam; Chen, Shen Mao; Vanaclocha, Leyre; Hart, Alister; El-Husseiny, Moataz; Henckel, Johann; Liu, Chaozong

    2017-11-01

    Osteoarthritis (OA) is the most common type of arthritis and a major cause of disability in the adult population. It affects both cartilage and subchondral bone in the joints. There has been some progress in understanding the changes in subchondral bone with progression of osteoarthritis. However, local changes in subchondral bone such as microstructure or volumetric bone mineral density in connection with the defect in cartilage are relatively unexplored. To develop an effective treatment for progression of OA, it is important to understand how the physical environment provided by the subchondral bone affects the overlying cartilage. In this study we examined the volumetric bone mineral density (vBMD) distribution in the osteoarthritic joint tissues obtained from total hip replacement surgeries due to osteoarthritis, using peripheral quantitative CT (pQCT). It was found that there is a significant decrease in volumetric bone mineral density, which co-localises with the damage in the overlying cartilage. This was not limited to the subchondral bone immediately adjacent to the cartilage defect but continued in the layers below. Bone resorption and cyst formation in the OA tissues were also detected. We observed that the bone surrounding subchondral bone cysts exhibited much higher volumetric bone mineral density than that of the surrounding bones. PQCT was able to detect significant changes in vBMD between OA and non-OA samples, as well as between areas of different cartilage degeneration, which points to its potential as a technique for detection of early OA.

  13. Quality of Bone Healing: Perspectives and Assessment Techniques

    Science.gov (United States)

    2014-01-01

    tibial fractures after intramed- ullary fixation. J Bone Joint Surg 2002; 84-B: 15–18. 41. Singh S, Song H-R, Venkatesh KP, Modi H, Park M, Jang K-M...Eur J Radiol 2009; 71: 392–7. 50. Engelke K. Assessment of bone quality and strength with new technologies. Curr Opin Endocrinol Diabetes Obes 2012...glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats. Osteoporos Int 2006; 17: 1514–23. 124. Vashishth D

  14. A comparative study of 99Tcm-MDP, 99Tcm(V)-DMSA and 99Tcm-Citrate in diagnosis of bone malignant tumors and bone/joint infections

    International Nuclear Information System (INIS)

    Wu Zhaozhong; Wu Boyi; Lin Wei; Wei Xueli; Wu Hengfu; Fan Ziwen; Ouyang Zhi; Wu Changwei; Yuan Gewen

    2003-01-01

    The purpose of this study was to assess the diagnostic value of scans with 99 Tc m (V)-dimercaptosuccinic acid (DMSA) to localize bone metastases and to evaluate the capability to diagnose bone/joint infections with scans using 99 Tc m -Citrate. Eighteen patients referred to bone metastases and eighteen patients referred to bone and joint infection were studied. In all patients, a bone scan of 99 Tc m -MDP was obtained initially. Subsequently, comparative scans with 99 Tc m (V)-DMSA and 99 Tc m -Citrate were conducted successively. Pathologic finding and/or microbiological finding, X-ray CT and/or MRI, and/or clinical follow-up (until symptoms disappeared) were considered to be proof of the presence of bone metastases and bone/joint infection. All of the eighteen patients with diagnosed bone metastases and of the eighteen patients with diagnosed bone and joint infection had positive 99 Tc m -MDP scintigraphy. The fifteen patients with diagnosed bone metastases and the fifteen patients with diagnosed bone/joint infection had increased 99 Tc m (V) -DMSA accumulation at certain areas matched with those shown in 99 Tc m -MDP scans, and only one patient with diagnosed bone metastases and the fifteen patients with diagnosed bone and joint infection had increased 99 Tc m -Citrate accumulation at certain areas matched with those shown in 99 Tc m -MDP scans. 99 Tc m -MDP scans show 64 bone lesions in the bone metastases while 49 lesions by the 99 Tc m (V)-DMSA scans and only one lesion by the 99 Tc m -Citrate scans respectively. And 99 Tc m -MDP scans show 22 bone lesions in the bone and joint infection while 17 lesions by the 99 Tc m (V)-DMSA imaging and 16 lesions by the 99 Tc m -Citrate imaging respectively. For bone metastases diagnosis, the sensitivity of 99 Tc m (V)-DMSA imaging and 99 Tc m -Citrate imaging were 76.56% and 1.56%, respectively, and the specificity were only 22.73% and 27.27%, respectively. For bone and joint infection diagnosis, the sensitivity of two

  15. Prospective analysis of a first MTP total joint replacement. Evaluation by bone mineral densitometry, pedobarography, and visual analogue score for pain

    DEFF Research Database (Denmark)

    Wetke, Eva; Zerahn, Bo; Kofoed, Hakon

    2012-01-01

    We hypothesized that a total replacement of the first metatarsophalangeal joint (MTP-1) would alter the walking pattern with medialisation of the ground reaction force (GRF) of the foot and subsequently cause an increase in bone mineral density (BMD) in the medial metatarsal bones and a decline o...

  16. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Including gamma correction interpretation. 4. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong-Whee [Sung Ae General Hospital, Seoul (Korea, Republic of). Dept. of Nuclear Medicine and Radiology

    2013-07-01

    In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.

  17. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Including gamma correction interpretation. 4. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Bahk, Yong-Whee

    2013-01-01

    In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.

  18. Pharmacokinetic variability of clindamycin and influence of rifampicin on clindamycin concentration in patients with bone and joint infections.

    Science.gov (United States)

    Curis, Emmanuel; Pestre, Vincent; Jullien, Vincent; Eyrolle, Luc; Archambeau, Denis; Morand, Philippe; Gatin, Laure; Karoubi, Matthieu; Pinar, Nicolas; Dumaine, Valérie; Nguyen Van, Jean-Claude; Babinet, Antoine; Anract, Philippe; Salmon, Dominique

    2015-08-01

    Clindamycin, a lincosamide antibiotic with a good penetration into bone, is widely used for treating bone and joint infections by Gram-positive pathogens. To be active against Staphylococcus spp, its concentration at the infection site, C, must be higher than 2× the minimal inhibitory concentration (MIC). The aims of the work were to study the determinants of plasma clindamycin trough concentration, C min, especially the effect of co-treatment with rifampicin, and the consequences on clinical outcome. An observational study was performed, involving patients hospitalized for a bone and joint infection who received clindamycin as part of their antibiotic treatment. Target C min was 1.7 mg/L, to reach the desired bone concentration/MIC >2, assuming a 30% diffusion into bone and MIC = 2.5 mg/L. Sixty one patients (mean age: 56.8 years, 57.4% male) were included between 2007 and 2011. 72.1% underwent a surgery on a foreign material, and 91.1% were infected by at least a Gram-positive micro-organism. Median C min value was 1.39 mg/L, with 58% of the values below the threshold value of 1.7 mg/L. Median C min was significantly lower for patients taking rifampicin (0.46 vs 1.52 mg/L, p = 0.034). No patient with rifampicin co-administration reached the target concentration (maximal C min: 0.85 mg/L). After a median follow-up of 17 months (1.5-38 months), 4 patients relapsed, 2 died and 47 (88.7% of the patients with known outcome) were cured, independently of association with rifampicin. This study shows the high inter-variability of plasma clindamycin concentration and confirms that co-treatment with rifampicin significantly decreases clindamycin trough concentrations.

  19. Surge-damping vacuum valve

    International Nuclear Information System (INIS)

    Bullock, J.C.; Kelley, B.E.

    1977-01-01

    A valve for damping out flow surges in a vacuum system is described. The surge-damping mechanism consists of a slotted, spring-loaded disk adjacent to the valve's vacuum port (the flow passage to the vacuum roughing pump). Under flow surge conditions, the differential pressure forces the disk into a sealing engagement with the vacuum port, thereby restricting the gas flow path to narrow slots in the disk's periphery. The increased flow damps out the flow surge. When pressure is equalized on both sides of the valve, the spring load moves the disk away from the port to restore full flow conductance through the valve

  20. Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.

    Science.gov (United States)

    Huebner, Janet L; Bay-Jensen, Anne C; Huffman, Kim M; He, Yi; Leeming, Diana J; McDaniel, Gary E; Karsdal, Morten A; Kraus, Virginia B

    2014-09-01

    To evaluate joint tissue remodeling using the urinary collagen biomarkers urinary α-C-telopeptide of type I collagen (α-CTX) and urinary C-telopeptide of type II collagen (CTX-II) and to determine the association of these biomarkers with osteoarthritis (OA) severity, progression, and localized knee bone turnover. Participants (n = 149) with symptomatic and radiographic knee OA underwent fixed-flexion knee radiography at baseline and 3 years, and late-phase bone scintigraphy of both knees at baseline, which were scored semiquantitatively for osteophyte and joint space narrowing (JSN) severity and uptake intensity, with scores summed across knees. Urinary concentrations of α-CTX and CTX-II were determined by enzyme-linked immunosorbent assay. Immunohistochemical analysis of human OA knees was performed to localize the joint tissue origin of the biomarker epitopes. Urinary α-CTX concentrations correlated strongly with the intensity of bone scintigraphic uptake and with JSN progression (risk ratio 13.2) and osteophyte progression (risk ratio 3). Urinary CTX-II concentrations were strongly associated with intensity of bone scintigraphic uptake, with JSN and osteophyte severity, and with OA progression based on osteophyte score. Urinary α-CTX localized primarily to high bone turnover areas in subchondral bone. CTX-II localized to the bone-cartilage interface, the tidemark, and damaged articular cartilage. Baseline urinary α-CTX, which was localized to high turnover areas of subchondral bone, was associated with dynamic bone turnover of knees, as signified by scintigraphy, and progression of both osteophytes and JSN. Urinary CTX-II correlated with JSN and osteophyte severity and progression of osteophytes. To our knowledge, this represents the first report of serologic markers reflecting subchondral bone turnover. These collagen markers may be useful for noninvasive detection and quantification of active subchondral bone turnover and joint remodeling in knee OA

  1. [Resection of a carpal bone row in a Pustertaler Sprinze cow with chronic purulent arthritis of the carpal joint and osteomyelitis].

    Science.gov (United States)

    Kofler, J; Peterbauer, C

    2014-01-01

    This case report describes the clinical and radiographic findings and the surgical treatment of a serofibrinous arthritis of the antebrachiocarpal joint and of a chronic purulent arthritis of the intercarpal and carpometacarpal joints with osteomyelitis of the distal carpal bones and subchondral osteomyelitis of the proximal metacarpal bones in a cow of the breed "Pustertaler Sprinze". The therapy comprised an arthrotomy of both joint spaces and the resection of the distal row of the carpal bones. The right forelimb had been immobilised for 70 days by a full limb cast. After this period, radiographs revealed an ob- vious ankylosis of the carpal joint, and the cow showed only a slight lameness. Six years postoperatively this cow was still in the herd and had produced six calves.

  2. Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis.

    Science.gov (United States)

    Wu, J; Wang, K; Xu, J; Ruan, G; Zhu, Q; Cai, J; Ren, J; Zheng, S; Zhu, Z; Otahal, P; Ding, C

    2017-09-01

    The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA. This study included 146 patients with symptomatic knee OA. Serum levels of ghrelin and cartilage or bone biomarkers including cartilage oligomeric matrix protein (COMP), cross linked C-telopeptide of type I collagen (CTXI), cross linked N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), and matrix metalloproteinase (MMP)-3, 10, 13 were measured using Enzyme-linked immunosorbent assay (ELISA). Knee symptoms were assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage defects, bone marrow lesions (BMLs) and effusion-synovitis were assessed using the (MRI). Osteophytes and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. After adjustment for potential confounders, ghrelin quartiles were positively associated with knee symptoms including pain, stiffness, dysfunction and total score (quartile 4 vs 1: β 24.19, 95% CI 8.13-40.25). Ghrelin quartiles were also significantly associated with increased IPFP signal intensity alteration (quartile 4 vs 1: OR 3.57, 95% CI 1.55-8.25) and NTXI, PIIINP, MMP3 and MMP13. Ghrelin was not significantly associated with other joint structures and biomarkers. Serum levels of ghrelin were significantly associated with increased knee symptoms, IPFP signal intensity alteration and serum levels of MMP3, MMP13, NTXI and PIIINP, suggesting that ghrelin may have a role to play in knee OA. Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  3. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.

    Science.gov (United States)

    Mak, Kingston Kinglun; Chen, Miao-Hsueh; Day, Timothy F; Chuang, Pao-Tien; Yang, Yingzi

    2006-09-01

    Both the Wnt/beta-catenin and Ihh signaling pathways play essential roles in crucial aspects of endochondral ossification: osteoblast differentiation, chondrocyte proliferation and hypertrophy. To understand the genetic interaction between these two signaling pathways, we have inactivated the beta-catenin gene and upregulated Ihh signaling simultaneously in the same cells during endochondral skeletal development using beta-catenin and patched 1 floxed alleles. We uncovered previously unexpected roles of Ihh signaling in synovial joint formation and the essential function of Wnt/beta-catenin signaling in regulating chondrocyte survival. More importantly, we found that Wnt and Ihh signaling interact with each other in distinct ways to control osteoblast differentiation, chondrocyte proliferation, hypertrophy, survival and synovial joint formation in the developing endochondral bone. Beta-catenin is required downstream of Ihh signaling and osterix expression for osteoblast differentiation. But in chondrocyte survival, beta-catenin is required upstream of Ihh signaling to inhibit chondrocyte apoptosis. In addition, Ihh signaling can inhibit chondrocyte hypertrophy and synovial joint formation independently of beta-catenin. However, there is a strong synergistic interaction between Wnt/beta-catenin and Ihh signaling in regulating synovial joint formation.

  4. Repair of large full-thickness articular cartilage defects in the rabbit: the effects of joint distraction and autologous bone-marrow-derived mesenchymal cell transplantation.

    Science.gov (United States)

    Yanai, T; Ishii, T; Chang, F; Ochiai, N

    2005-05-01

    We produced large full-thickness articular cartilage defects in 33 rabbits in order to evaluate the effect of joint distraction and autologous culture-expanded bone-marrow-derived mesenchymal cell transplantation (ACBMT) at 12 weeks. After fixing the knee on a hinged external fixator, we resected the entire surface of the tibial plateau. We studied three groups: 1) with and without joint distraction; 2) with joint distraction and collagen gel, and 3) with joint distraction and ACBMT and collagen gel. The histological scores were significantly higher in the groups with ACBMT collagen gel (p distraction, collagen gel and ACBMT.

  5. Dual-energy CT for detection of traumatic bone bruises in the knee joint

    International Nuclear Information System (INIS)

    Seo, Sang Hyun; Sohn, Young Jun; Lee, Chong Ho; Park, Seong Hoon; Kim, Hye Won; Juhng, Seon Kwan

    2013-01-01

    To evaluate the diagnostic performance of dual-energy computed tomography (DECT) in detecting traumatic bone marrow lesions in patients with acute knee injury. Between August 2011 and June 2012, 22 patients presenting with an acute knee injury, including 4 patients who were referred for bilateral knee trauma, underwent DECT (80 kVp and 140 kVp) and MR imaging. DECT data were postprocessed using a three-dimensional, color-coded, virtual non-calcium technique (VNC). DECT data were graded by 2 blinded independent readers using a four-point system (1 = distinct bone marrow lesion, 2 = less distinct bone marrow lesion, 3 = equivocal, 4 = none) for 6 femoral and tibial regions and 2 patellar regions. Routine MR knee imaging served as the reference standard. MR images showed bone bruises in 81 of 364 regions. The overall sensitivity, specificity, positive predictive value, and negative predictive value of DECT for bone bruises were 65.4%, 98.2%, 91.4%, and 90.8%, respectively, for Reader 1 and 70.3%, 93.6%, 76.0%, and 91.7%, respectively, for Reader 2. In particular, tibial bone bruises could be found more easily with better sensitivity (80.2%). The color-coded VNC technique with reconstructions from the DECT maybe helpful in detecting traumatic bone bruises with moderate sensitivity and excellent specificity compared to MR imaging.

  6. Dual-energy CT for detection of traumatic bone bruises in the knee joint

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Sang Hyun; Sohn, Young Jun; Lee, Chong Ho; Park, Seong Hoon; Kim, Hye Won; Juhng, Seon Kwan [Dept. of Radiology, Wonkwang University Hospital, Iksan (Korea, Republic of)

    2013-12-15

    To evaluate the diagnostic performance of dual-energy computed tomography (DECT) in detecting traumatic bone marrow lesions in patients with acute knee injury. Between August 2011 and June 2012, 22 patients presenting with an acute knee injury, including 4 patients who were referred for bilateral knee trauma, underwent DECT (80 kVp and 140 kVp) and MR imaging. DECT data were postprocessed using a three-dimensional, color-coded, virtual non-calcium technique (VNC). DECT data were graded by 2 blinded independent readers using a four-point system (1 = distinct bone marrow lesion, 2 = less distinct bone marrow lesion, 3 = equivocal, 4 = none) for 6 femoral and tibial regions and 2 patellar regions. Routine MR knee imaging served as the reference standard. MR images showed bone bruises in 81 of 364 regions. The overall sensitivity, specificity, positive predictive value, and negative predictive value of DECT for bone bruises were 65.4%, 98.2%, 91.4%, and 90.8%, respectively, for Reader 1 and 70.3%, 93.6%, 76.0%, and 91.7%, respectively, for Reader 2. In particular, tibial bone bruises could be found more easily with better sensitivity (80.2%). The color-coded VNC technique with reconstructions from the DECT maybe helpful in detecting traumatic bone bruises with moderate sensitivity and excellent specificity compared to MR imaging.

  7. Human bones obtained from routine joint replacement surgery as a tool for studies of plutonium, americium and {sup 90}Sr body-burden in general public

    Energy Technology Data Exchange (ETDEWEB)

    Mietelski, Jerzy W., E-mail: jerzy.mietelski@ifj.edu.pl [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Edward B. [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Department of Physical Therapy Basics, Faculty of Physical Therapy, Administration College, Bielsko-Biala (Poland); Tomankiewicz, Ewa [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland); Golec, Joanna [Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Nowak, Sebastian [Traumatology and Orthopaedic Clinic, 5th Military Clinical Hospital and Polyclinic, Independent Public Healthcare Facility, Wroclawska 1-3, 30-901 Cracow (Poland); Orthopaedic Rehabilitation Department, Chair of Clinical Rehabilitation, Faculty of Motor of the Bronislaw Czech' s Academy of Physical Education, Cracow (Poland); Szczygiel, Elzbieta [Physical Therapy Department, Institute of Physical Therapy, Faculty of Heath Science, Jagiellonian University, Medical College, Cracow (Poland); Brudecki, Kamil [Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Cracow (Poland)

    2011-06-15

    The paper presents a new sampling method for studying in-body radioactive contamination by bone-seeking radionuclides such as {sup 90}Sr, {sup 239+240}Pu, {sup 238}Pu, {sup 241}Am and selected gamma-emitters, in human bones. The presented results were obtained for samples retrieved from routine surgeries, namely knee or hip joints replacements with implants, performed on individuals from Southern Poland. This allowed to collect representative sets of general public samples. The applied analytical radiochemical procedure for bone matrix is described in details. Due to low concentrations of {sup 238}Pu the ratio of Pu isotopes which might be used for Pu source identification is obtained only as upper limits other then global fallout (for example Chernobyl) origin of Pu. Calculated concentrations of radioisotopes are comparable to the existing data from post-mortem studies on human bones retrieved from autopsy or exhumations. Human bones removed during knee or hip joint surgery provide a simple and ethical way for obtaining samples for plutonium, americium and {sup 90}Sr in-body contamination studies in general public. - Highlights: > Surgery for joint replacement as novel sampling method for studying in-body radioactive contamination. > Proposed way of sampling is not causing ethic doubts. > It is a convenient way of collecting human bone samples from global population. > The applied analytical radiochemical procedure for bone matrix is described in details. > The opposite patient age correlations trends were found for 90Sr (negative) and Pu, Am (positive).

  8. Electrodynamics properties of auroral surges

    International Nuclear Information System (INIS)

    Robinson, R.M.; Vondrak, R.R.

    1990-01-01

    The incoherent scatter radar technique provides an excellent means to study the ionization and electric fields associated with auroral precipitation events. One of the most intense and dynamic auroral events is the so-called surge or breakup aurora that accompanies auroral substorms. For their purposes they define a surge as a transient intensification of auroral precipitation that occurs simultaneously with a pronounced negative bay in the ground magnetometer data. They present data obtained during five such events in 1980 and 1981. Prior to the surge, auroral forms move equatorward, develop ray structure, and intensify. The surge is identified by an apparent poleward motion of the aurora producing aurorally associated ionization that extends over several hundred kilometers in latitude. The presurge auroral forms are embedded in a region of northward electric field. The auroral forms that comprise the surge span a region within which the meridional electric field is small and at times southward. A westward electric field is often but not always present within the surge. The behavior of the westward electric field is significantly different from the north-south field, in that sharp spatial gradients are absent even in very disturbed conditions. Although the westward Hall currents are mostly responsible for the negative bays that accompany the surge, at times the westward Pedersen current sustained by the westward electric field can be important. Sudden variations in the H component of the ground magnetogram can be caused by motions of the aurora or by temporal variations in the fields or conductivities. They present a model that simulates the observed changes in electric field and precipitation that accompany surges. The perturbation in the electric field produced by the surge is simulated by adding negative potential in regions of intense precipitation

  9. Radionuclide bone scintigraphy in the detection of significant complications after total knee joint replacement

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.L.; Wastie, M.L.; Forster, I

    2001-03-01

    AIM: Post-arthroplasty knee pain is common and clinically it can be difficult to identify those patients with complications requiring active treatment. The aim of this study was to determine the usefulness of{sup 99}Tc{sup m}-MDP bone scintigraphy. METHOD: A retrospective study of all patients having a{sup 99}Tc{sup m}-MDP bone scintigram for a painful knee arthroplasty between 1993 and 1999 was performed. Bone scintigrams were classified as normal or abnormal by a single observer. The results of these investigations were correlated with clinical outcome. RESULTS: Seventy-five patients with painful knee arthroplasties were referred for investigation. A total of 80 bone scintigrams were performed. The average patient age was 66.2 years (42 female and 33 male). The mean time period between surgery and onset of knee pain was 3 years. A final clinical diagnosis based on arthroscopy, open surgery, and extended clinical follow-up was available for all patients. Forty-three (53.8%) of the scintigrams were normal and 37 (46.3%) abnormal. Two patients with a normal bone scintigram has loose prostheses. Thirteen patients with an abnormal study had normal prostheses on follow-up and these tended to be patients scanned less than a year after surgery. The sensitivity, specificity, positive predictive value and negative predictive value of an unequivocally normal or abnormal bone scintigram was 92.3, 75.9, 64.9 and 95.0%, respectively. The pattern of isotope uptake in the abnormal studies was not specific enough to reliably differentiate aseptic from septic loosening. CONCLUSION: Radionuclide bone scintigraphy is useful in the assessment of the painful knee arthroplasty. A negative bone scintigram is reassuring and makes loosening or infection unlikely. Smith, S.L. et al. (2001)

  10. Radionuclide bone scintigraphy in the detection of significant complications after total knee joint replacement

    International Nuclear Information System (INIS)

    Smith, S.L.; Wastie, M.L.; Forster, I.

    2001-01-01

    AIM: Post-arthroplasty knee pain is common and clinically it can be difficult to identify those patients with complications requiring active treatment. The aim of this study was to determine the usefulness of 99 Tc m -MDP bone scintigraphy. METHOD: A retrospective study of all patients having a 99 Tc m -MDP bone scintigram for a painful knee arthroplasty between 1993 and 1999 was performed. Bone scintigrams were classified as normal or abnormal by a single observer. The results of these investigations were correlated with clinical outcome. RESULTS: Seventy-five patients with painful knee arthroplasties were referred for investigation. A total of 80 bone scintigrams were performed. The average patient age was 66.2 years (42 female and 33 male). The mean time period between surgery and onset of knee pain was 3 years. A final clinical diagnosis based on arthroscopy, open surgery, and extended clinical follow-up was available for all patients. Forty-three (53.8%) of the scintigrams were normal and 37 (46.3%) abnormal. Two patients with a normal bone scintigram has loose prostheses. Thirteen patients with an abnormal study had normal prostheses on follow-up and these tended to be patients scanned less than a year after surgery. The sensitivity, specificity, positive predictive value and negative predictive value of an unequivocally normal or abnormal bone scintigram was 92.3, 75.9, 64.9 and 95.0%, respectively. The pattern of isotope uptake in the abnormal studies was not specific enough to reliably differentiate aseptic from septic loosening. CONCLUSION: Radionuclide bone scintigraphy is useful in the assessment of the painful knee arthroplasty. A negative bone scintigram is reassuring and makes loosening or infection unlikely. Smith, S.L. et al. (2001)

  11. X-ray changes in the bones and joints in arthropatic psoriasis

    International Nuclear Information System (INIS)

    Spuzyak, M.Yi.; Olyijnik, Yi.O.

    2009-01-01

    Dynamic x-ray investigation was performed in 136 patients aged 16-64/ It included radiography of the spine, hands, feet, pelvis, hip, knee, ankle, radiocarpal, metatarsal and sometimes shoulder and elbow joints.

  12. [Clinical application of continuous douche and vacuum sealing drainage in refractory tissue, bone and joint infections after debridement].

    Science.gov (United States)

    Yang, Ping-lin; He, Xi-jing; Li, Hao-peng; Wang, Guo-yu; Zang, Quan-jin

    2010-01-01

    To explore effect and the application value of continuous douche and vacuum sealing drainage (VSD) in refractory tissue, and joint infections after complete debridement. As retrospective analysis of treatment time and restoration or recurrence, from Jan. 2006 to Dec. 2007, 61 cases of refractory tissue, bone and joint infections underwent continuous douche and VSD combined with the treatment of anti-inflammatory and rehabilitation training after debridement in our hospital. The 61 patients included 39 males and 22 females with age ranging from 10 to 58 years with an average of (35 +/- 12) years, among whom 61 identified to have ankle ulcers combined with infections,open fracture combined with infections, sacrococcygeal pressure ulcers combined with infections, infections after hip replacement, infections after open fracture, and infections after skin avulsion postoperation were 11, 15, 9, 3, 5 and 18 cases respectively. The course was from 2 weeks to 11 months with an average of 4 months. In all 61 patients,the mean healing time was 17, 36, 42, 24, 32, 29 and 28 days in ankle ulcers and infections, tibia and fibula open fracture and infections, femoral shaft fracture and infections, sacrococcygeal pressure ulcers and infections, infections after hip replacement, infections after open fracture, and infections after skin avulsion postoperation respectively. The replacement of VSD was 1, 2-4, 3-5, 1-3, 2-4, 2-3 and 1-3 times in each group respectively. There was no wound recurrence except for 2 cases with recurrent in 61 cases with external fixation nail hole semi-pathological fracture in 1 case of femoral shaft fracture and infection and 1 case of tibia and fibula fracture and infection after follow-up at least one year. Application of continuous douche and VSD can effectively decrease incidence of complications and promote the refractory tissue, bone and joint infections wound growth, healing and considerably shorten the healing time.

  13. Distribution of vitamin K2 in subchondral bone in osteoarthritic knee joints.

    Science.gov (United States)

    Ishii, Yoshinori; Noguchi, Hideo; Takeda, Mitsuhiro; Sato, Junko; Yamamoto, Noriaki; Wakabayashi, Hiroyuki; Kanda, Junkichi; Toyabe, Shin-ichi

    2013-08-01

    Vitamin K may have multiple effects on articular cartilage and subchondral bone that could modulate the pathogenesis of osteoarthritis (OA). The purpose of this study was to evaluate the distribution of vitamin K2 in harvested bones obtained during total knee arthroplasty in knee OA patients. High-performance liquid chromatography was used to measure vitamin K2 in harvested bones obtained during 58 TKA procedures. Vitamin K2 levels were analysed in the medial (FM) and lateral (FL) femoral condyles and in the medial (TM) and lateral (TL) tibial condyles. There was significantly more vitamin K2 in the lateral femoral and tibial condyles than in the corresponding medial condyles (FL vs. FM, p K2 in the FL than in the TL (p = 0.003), and in the FM, vitamin K2 levels were higher than those of the TM, although this was not significant (n.s.). There were no significant differences in vitamin K2 levels in men versus women nor was there a significant correlation with age. This study suggested that vitamin K2 might affect bone turnover since medial condyles showing advanced OA had lower vitamin K2 levels, while lateral condyles showing less advanced OA contained more vitamin K2. Gender and age were not correlated with vitamin K2 localization. All cases had Grade IV OA, and this study suggested that OA grade might be important in controlling the vitamin K2 levels in human bones.

  14. Construction of computational models for the stress analysis of the bones using CT imaging: application in the gleno-humeral joint

    International Nuclear Information System (INIS)

    Cisilino, Adrian; D'Amico, Diego; Buroni, Federico; Commisso, Pablo; Sammartino, Mario; Capiel, Carlos

    2008-01-01

    A methodology for the construction of computational models from CT images is presented in this work. Computational models serve for the stress analysis of the bones using the Finite Element Method. The elastic constants of the bone tissue are calculated using the density data obtained in from the CTs. The proposed methodology is demonstrated in the construction of a model for the gleno-humeral joint. (authors) [es

  15. Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate.

    Directory of Open Access Journals (Sweden)

    Xue-Dong Wang

    Full Text Available BACKGROUND: Osteoarthritis (OA is an important subtype of temporomandibular disorders. A simple and reproducible animal model that mimics the histopathologic changes, both in the cartilage and subchondral bone, and clinical symptoms of temporomandibular joint osteoarthritis (TMJOA would help in our understanding of its process and underlying mechanism. OBJECTIVE: To explore whether injection of monosodium iodoacetate (MIA into the upper compartment of rat TMJ could induce OA-like lesions. METHODS: Female rats were injected with varied doses of MIA into the upper compartment and observed for up to 12 weeks. Histologic, radiographic, behavioral, and molecular changes in the TMJ were evaluated by light and electron microscopy, MicroCT scanning, head withdrawal threshold test, real-time PCR, immunohistochemistry, and TUNEL assay. RESULTS: The intermediate zone of the disc loosened by 1 day post-MIA injection and thinned thereafter. Injection of an MIA dose of 0.5 mg or higher induced typical OA-like lesions in the TMJ within 4 weeks. Condylar destruction presented in a time-dependent manner, including chondrocyte apoptosis in the early stages, subsequent cartilage matrix disorganization and subchondral bone erosion, fibrosis, subchondral bone sclerosis, and osteophyte formation in the late stages. Nociceptive responses increased in the early stages, corresponding to severe synovitis. Furthermore, chondrocyte apoptosis and an imbalance between anabolism and catabolism of cartilage and subchondral bone might account for the condylar destruction. CONCLUSIONS: Multi-level data demonstrated a reliable and convenient rat model of TMJOA could be induced by MIA injection into the upper compartment. The model might facilitate TMJOA related researches.

  16. Diagnostic value of bone scintigraphy with sup(99m)Tc-pyrophosphate for evaluation of complications after hip joint replacement

    International Nuclear Information System (INIS)

    Baumer, J.F.

    1979-01-01

    For 102 patients with complaints after total hip replacement, bone scintigraphies with sup(99m)Tc have been made in addition to the usual examinations. 95 of these patients had to be operated once more, whereas the infected endoprosteses detected in the remaining 7 patients have been treated for the time being by non-surgical measures. In 68 patients, the examination revealed an aseptic loosening of the total endoprosthesis, including fracture of the diaphysis in 19 cases. In one case, a replacement of the prosthesis had been necessary in spite of the alloarthroplasty being firmly fixed in the right place. The bacterioscopic and bacteriologic investigations clearly revealed an infection of the environment of the prosthesis, in 27 patients, whereas the findings obtained on 6 other patients have not been as unambiguons. 85% of the patients with septic complications showed an increased E.S.R., however only 26% of the patients with aseptic complications. In only 47% of the patients with infection of the hip joint, bacteria have been found in the hip joint puncture fluid, whereas the bacteriological examination of tissue taken from the environment of the artificial hip joint during the operation revealed no increase in bacteria in only one case (5%). In 4 patients (20%), the bacterioscopic findings showed no signs of an acute infection, although saprophytic germs had been isolated from the environment of the prosthesis. 78% of the cases with loosening of the prosthesis and 11% of the infections have been detected by X-ray examination. The nuclear medical examination showed normal radionuclide accumulation in 30% of the cases with loosened prosthesis and in 4% of the infections, for 6% each of the two complications the scintigrams yielded no unambiguous results. In 4 patients (40%) with total hip joint replacement on both sides, enhanced radionuclide accumulation has been abserved even on the symptom-free side. (orig./AJ) [de

  17. Post-traumatic changes of the temporo-mandibular joint by bone scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Harris, S.A.; Rood, J.P.; Testa, H.J.

    1988-01-01

    13 patients who sustained mandibular trauma were investigated with radiographs and scintiscans. The scintiscans showed abnormal uptake of radiopharmaceutical in the temporomandibular joint (TMJ). In patients with a long history of traumatic arthrosis, there was more positive correlation between the scintiscans, and clinical symptoms and histology than between radiographs, and symptoms and histology. In patients with mandibular body fractures and no TMJ symptoms, the scans showed abnormal uptake in the TMJ in 7/8 joints, in the absence of radiographic abnormality. The significance of the abnormal uptake and the value of scintigraphy is discussed.

  18. X-ray morphology of the joints and the bones of the extremities of aged people

    International Nuclear Information System (INIS)

    Olah, J.

    1978-01-01

    The radiograms of the healthy extremities of aged people are analyzed and the normal formations, typical at higher age, are differentiated from the pathological phenomena. The ''physiological'' decalcification can cause the following symptoms: trabecular microfractures, areas without structure, pseudoforamena, discrete spicules at the edges of the joints, periostoses, fibrous structure of the compacta. The deformations occurring in the different joints are detailed. The relationship between high age and arthrosis is also investigated. It is concluded that the occurrence of arthrosis is not inevitable and it is not seriously influenced neither by the weight nor by the profession of the patient. The thesis contains 49 radiograms. (L.E.)

  19. Post-traumatic changes of the temporo-mandibular joint by bone scintigraphy

    International Nuclear Information System (INIS)

    Harris, S.A.; Rood, J.P.; Testa, H.J.

    1988-01-01

    13 patients who sustained mandibular trauma were investigated with radiographs and scintiscans. The scintiscans showed abnormal uptake of radiopharmaceutical in the temporomandibular joint (TMJ). In patients with a long history of traumatic arthrosis, there was more positive correlation between the scintiscans, and clinical symptoms and histology than between radiographs, and symptoms and histology. In patients with mandibular body fractures and no TMJ symptoms, the scans showed abnormal uptake in the TMJ in 7/8 joints, in the absence of radiographic abnormality. The significance of the abnormal uptake and the value of scintigraphy is discussed. (author)

  20. A new condyle implant design concept for an alloplastic temporomandibular joint in bone resorption cases.

    Science.gov (United States)

    Ramos, António; Mesnard, Michel

    2016-10-01

    The purpose of this article is to present and evaluate an innovative intramedullary implant concept developed for total alloplastic reconstruction in bone resorption cases. The main goal of this innovative concept is to avoid the main problems experienced with temporomandibular (TMJ) devices on the market, associated with bone fixation and changes in kinematics. A three-dimensional finite element model was developed based on computed tomography (CT) scan images, before and after implantation of the innovative implant concept. To validate the numerical model, a clean cadaveric condyle was instrumented with four rosettes and loaded before and after implantation with the innovative concept TMJ implant. The experimental results validate the numerical models comparing the intact and implanted condyles, as they present good correlation. They show that the most critical region is around rosette #1, with an increase in strains in the proximal region of the condyle of 140%. The maximum principal strain and stress generated with the implant is less than 2200 με and 75 MPa in the posterior region of the cortical bone. Shortly after insertion of this press-fit implant, stress and strain results appear to be within the normal limits and show some similarities with the intact condyle. If these responses do not change over time, the screw fixation used at present could be avoided or replaced. This solution reduces bone resection and lessens surgical damage to the muscles. Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  1. Bone remodeling after hip joint replacement. Numerical Modeling and Comparism with Clinical Observation

    Czech Academy of Sciences Publication Activity Database

    Klika, Václav; Maršík, František; Landor, I.

    2007-01-01

    Roč. 14, 3-4 (2007), s. 340-343 ISSN 1212-4575. [Prague-Sydney-Lublin Symposium /9./, Kubát's Podiatric Day /12./. Prague, 19.10.2007-20.10.2007] Institutional research plan: CEZ:AV0Z20760514 Keywords : bone remodeling * prosthesis * RANKL/RANK/OPG pathway Subject RIV: BO - Biophysics

  2. MRI of degenerative bone marrow lesions in experimental osteoarthritis of canine knee joints

    Energy Technology Data Exchange (ETDEWEB)

    Nolte-Ernsting, C.C.A. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Adam, G. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Buehne, M. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany); Prescher, A. [Department of Anatomy, University of Technology, Aachen (Germany); Guenther, R.W. [Department of Diagnostic Radiology, University of Technology, Aachen, Pauwelsstrasse 30, D-52057 Aachen (Germany)

    1996-07-01

    Objective. The objective of this study was to determine the value of MRI in the detection of degenerative bone marrow abnormalities in an animal osteoarthritis model. Design. In 10 dogs with experimentally induced unilateral osteoarthritis of the knee, MRI was performed using two-dimensional spin-echo (2D-SE) and three-dimensional gradient-echo (3D-GE) imaging. Contrast enhanced T1-weighted 2D-SE sequences were also obtained after injection of gadolinium-DTPA. The results were compared with the gross and histopathologic findings and with radiography. Results. Histopathologic specimens revealed 21 osteosclerotic lesions and 5 intraosseous cysts. On 2D-SE images, 24 of 26 lesions were detected, while 21 of 26 lesions were identified on 2D-GE sequences. Radiography, including conventional tomography, demonstrated 9 of 26 lesions. Regardless of the sequence weighting, all osteosclerotic lesions appeared hypointense on MRI. Signal loss in bone sclerosis resulted primarily from the reduction of intact fat marrow, the increased bone density being of secondary importance. Quantitative signal analysis allowed approximate estimation of the grade of sclerosis. On postcontrast images, sclerotic bone remained hypointense, although significant but non-specific enhancement relative to the normal fat marrow was observed. The extent of contrast enhancement did not correlate with the grade of osteosclerosis. All five cysts were readily diagnosed by MRI. Cysts displayed either central or marginal contrast enhancement within their cavities. Conclusions. MRI provides a sensitive method for the diagnosis of osteoarthritic bone abnormalities, allowing their differentiation from most non-degenerative subarticular lesions. (orig.). With 1 tab.

  3. Effect of indomethacin on regulation of juxta-articular bone blood-flow during joint tamponade. An experimental study in puppies

    DEFF Research Database (Denmark)

    Ewald, Henrik Lykke; Holm, I E; Bülow, J

    1989-01-01

    Prostaglandins are vasoactive substances which are assumed to play a major role in bone metabolism and bone repair. The purpose of the present study was to investigate the effect of indomethacin on the control of epiphyseal bone blood-flow. By means of simultaneous intra-osseous pressure (IOP......) and regional blood flow (RBF) measurements in the distal femoral epiphysis (DFE), aspects of vascular control mechanisms in the distal femoral epiphysis were investigated during knee joint tamponade (50% of mean arterial pressure) before and after administration of indomethacin 7.5 mg/kg. Six dogs aged 3...

  4. Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements

    Czech Academy of Sciences Publication Activity Database

    Zolotarevova, E.; Entlicher, G.; Pavlova, Ewa; Šlouf, Miroslav; Pokorný, D.; Veselý, F.; Gallo, J.; Sosna, A.

    2010-01-01

    Roč. 6, č. 9 (2010), s. 3595-3600 ISSN 1742-7061 R&D Projects: GA MŠk 2B06096 Institutional research plan: CEZ:AV0Z40500505 Keywords : joint replacement * polyethylene * wear particles distribution Subject RIV: CD - Macromolecular Chemistry Impact factor: 4.824, year: 2010

  5. Optimized cervical spine bone SPET for detection of facet joint injury after whiplash injury

    Energy Technology Data Exchange (ETDEWEB)

    Cardaci, G T; Bower, G D; Taylor, J [Perth and Perth Pain Management, South Perth, WA (Australia). Mount Medical Centre, Isotope Imaging

    1999-04-01

    Full text: The most frequent origin for chronic cervical pain in patients with a remote history of whiplash injury is the cervical facet joints. Exact localization of facet joint injury is difficult and currently advocated methods include multiple invasive diagnostic injections. Optimization of {sup 99}Tc{sup m}-HDP cervical SPET (CSPET) to accurately localize facet joint pathology was attempted and the results correlated with clinical localization relying on focal joint tenderness and passive movement methods. Imaging was performed on a dual-headed gamma camera system using an elliptical orbit over 360 deg. The patient's neck was flexed to eliminate the cervical lordosis. Reconstructed CSPET images were reorientated into the long axis of the vertebral bodies. CSPET studies were independently scored by two observers blinded to the clinical and other imaging information and correlated with clinical localization and response to radiofrequency ablation. 54 patients have been studied using this technique in a prospective study. Early patient follow-up data will be presented. CSPET was felt to be clinically useful by pain therapists in targeting treatment.

  6. Optimized cervical spine bone SPET for detection of facet joint injury after whiplash injury

    International Nuclear Information System (INIS)

    Cardaci, G.T.; Bower, G.D.; Taylor, J.

    1999-01-01

    Full text: The most frequent origin for chronic cervical pain in patients with a remote history of whiplash injury is the cervical facet joints. Exact localization of facet joint injury is difficult and currently advocated methods include multiple invasive diagnostic injections. Optimization of 99 Tc m -HDP cervical SPET (CSPET) to accurately localize facet joint pathology was attempted and the results correlated with clinical localization relying on focal joint tenderness and passive movement methods. Imaging was performed on a dual-headed gamma camera system using an elliptical orbit over 360 deg. The patient's neck was flexed to eliminate the cervical lordosis. Reconstructed CSPET images were reorientated into the long axis of the vertebral bodies. CSPET studies were independently scored by two observers blinded to the clinical and other imaging information and correlated with clinical localization and response to radiofrequency ablation. 54 patients have been studied using this technique in a prospective study. Early patient follow-up data will be presented. CSPET was felt to be clinically useful by pain therapists in targeting treatment

  7. Low bone mineral density is associated with reduced hip joint space width in women: results from the Copenhagen Osteoarthritis Study

    DEFF Research Database (Denmark)

    Jacobsen, Steffen; Jensen, Trine W; Bach-Mortensen, Pernille

    2007-01-01

    inconclusive. The present cross-sectional study investigated the relationship between reduced bone mineral density (BMD), as a surrogate parameter of endogenous estrogen status assessed by digital x-ray radiogrammetry, and reduced minimum hip joint space width (JSW). DESIGN: Standardized hand radiographs...... of the Copenhagen Osteoarthritis Study cohort of 3,913 adults (1,470 male/2,443 female) with a mean age of 60 years (range, 18-92) were analyzed using X-Posure digital software, version 2.0 (Sectra-Pronosco). The system is operator independent. From 1,200 individual measurements per radiograph, mean BMD...... was calculated. Minimum hip JSW was assessed on standardized pelvic radiographs. RESULTS: Digital x-ray radiogrammetry BMD decreased in both men and women after the age of 45 years, progressively more so in women. Although minimum hip JSW in men remained relatively unaltered throughout life, a marked decline...

  8. The Early Impact of an Administrative Processing Fee on Manuscript Submissions at The Journal of Bone & Joint Surgery.

    Science.gov (United States)

    Nwachukwu, Benedict U; Schairer, William W; So, Conan; Bernstein, Jaime L; Herndon, James; Dodwell, Emily R

    2016-10-05

    There was a dramatic increase in the volume of manuscripts submitted to The Journal of Bone & Joint Surgery (JBJS) between 2009 and 2012. This resulted in increased journal administrative costs. To offset this financial burden, in May 2013, JBJS started charging authors an administrative processing fee at the time of submission. The purpose of this study was to assess the impact of the administrative fee on the volume and characteristics of manuscripts submitted to JBJS. Our analysis included 866 manuscripts submitted to JBJS between November 2012 and November 2013. We compared manuscripts submitted 6 months prior to fee implementation and prior to the announcement (denoted as the baseline group), in the several months prior to fee implementation but after the fee implementation announcement (denoted as the fee announcement group), and in the 6 months after fee implementation (denoted as the fee implementation group). Manuscripts were reviewed for institutional and author demographic characteristics, as well as for general study characteristics. In the first full calendar year (2014) after the implementation of the fee, the annual volume of submissions to JBJS declined by 33.5% compared with the annual submission volume in 2010 to 2012. In a comparative analysis, the geographical region of origin (p = 0.003), level of evidence (p Reporting of funding information improved significantly between the baseline and fee implementation groups; in the post-fee implementation period, studies were more likely to have declared no external funding source (p = 0.001). The administrative processing fee at JBJS has been associated with a decrease in submission volume, but, overall, there has not been a change in the characteristics of studies submitted. However, decreased overall volume implies a decrease in the absolute number of high-level studies submitted to the journal. Administrative processing fees at high-volume journals may be a financially viable way to offset high

  9. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) ; Guidance on the scientific requirements for health claims related to bone, joints, skin and oral health

    DEFF Research Database (Denmark)

    Tetens, Inge

    The Panel on Dietetic Products, Nutrition and Allergies (NDA) has been asked by the European Food Safety Authority (EFSA) to draft guidance on the scientific requirements for health claims related to bone, joints, skin, and oral health. This guidance has been drawn from scientific opinions...

  10. The acutely ACL injured knee assessed by MRI: changes in joint fluid, bone marrow lesions, and cartilage during the first year

    DEFF Research Database (Denmark)

    Frobell, R B; Le Graverand, M-P; Buck, R

    2008-01-01

    OBJECTIVES: To investigate changes in the knee during the first year after acute rupture of the anterior cruciate ligament (ACL) of volumes of joint fluid (JF), bone marrow lesions (BMLs), and cartilage volume (VC), and cartilage thickness (ThCcAB) and cartilage surface area (AC). To identify fac...

  11. Early diagnostics of temporomandibular joint structural elements injures caused by traumatic mandibular bone fractures.

    Science.gov (United States)

    Pohranychna, Kh R; Stasyshyn, A R; Matolych, U D

    2017-06-30

    A rapidly increasing number of mandibular condylar fractures and some complications related to injuries of temporomandibular elements make this study important. Intra-articular disorders lead to secondary pathological findings such as osteoarthritis, deforming osteoarthrosis, and temporomandibular joint ankylosis that limits mouth opening, mastication, swallowing, breathing, and decreased/lost working capacity or disability. Early diagnosis of intra-articular disorders can prevent from long-lasting functional complications caused by temporomandibular joint injuries. This study was performed for the purpose of early detection and investigation of organic pathological changes in the cartilaginous and osseous tissues of the temporomandibular joint caused by traumatic fractures of the mandibular condyle. Twenty patients underwent a general clinical examination, magnetic resonance imaging (MRI), and immune-enzyme testing for biochemical markers of connective tissue injury (pyridinoline and deoxypyridinoline) in urine. Disk dislocation, deformation, adhesion, perforation or squeeze, tension or disruption of ligaments, and injury of articular surfaces are among complications of mandibular fractures that can be revealed on MRI. As regards biochemical findings, we revealed a sharp rise in the levels of pyridinoline and deoxypyridinoline before treatment and a lack of stabilization within 21 days of treatment.

  12. Oral versus intravenous antibiotic treatment for bone and joint infections (OVIVA): study protocol for a randomised controlled trial.

    Science.gov (United States)

    Li, Ho Kwong; Scarborough, Matthew; Zambellas, Rhea; Cooper, Cushla; Rombach, Ines; Walker, A Sarah; Lipsky, Benjamin A; Briggs, Andrew; Seaton, Andrew; Atkins, Bridget; Woodhouse, Andrew; Berendt, Anthony; Byren, Ivor; Angus, Brian; Pandit, Hemant; Stubbs, David; McNally, Martin; Thwaites, Guy; Bejon, Philip

    2015-12-21

    Bone and joint infection in adults arises most commonly as a complication of joint replacement surgery, fracture fixation and diabetic foot infection. The associated morbidity can be devastating to patients and costs the National Health Service an estimated £20,000 to £40,000 per patient. Current standard of care in most UK centres includes a prolonged course (4-6 weeks) of intravenous antibiotics supported, if available, by an outpatient parenteral antibiotic therapy service. Intravenous therapy carries with it substantial risks and inconvenience to patients, and the antibiotic-related costs are approximately ten times that of oral therapy. Despite this, there is no evidence to suggest that oral therapy results in inferior outcomes. We hypothesise that, by selecting oral agents with high bioavailability, good tissue penetration and activity against the known or likely pathogens, key outcomes in patients managed primarily with oral therapy are non-inferior to those in patients treated by intravenous therapy. The OVIVA trial is a parallel group, randomised (1:1), un-blinded, non-inferiority trial conducted in thirty hospitals across the UK. Eligible participants are adults (>18 years) with a clinical syndrome consistent with a bone, joint or metalware-associated infection who have received ≤7 days of intravenous antibiotic therapy from the date of definitive surgery (or the start of planned curative therapy in patients treated without surgical intervention). Participants are randomised to receive either oral or intravenous antibiotics, selected by a specialist infection physician, for the first 6 weeks of therapy. The primary outcome measure is definite treatment failure within one year of randomisation, as assessed by a blinded endpoint committee, according to pre-defined microbiological, histological and clinical criteria. Enrolling 1,050 subjects will provide 90 % power to demonstrate non-inferiority, defined as less than 7.5 % absolute increase in treatment

  13. An analysis of the combination frequencies of constituent medicinal herbs in prescriptions for the treatment of bone and joint disorder in Korean medicine: determination of a group of candidate prescriptions for universal use

    Directory of Open Access Journals (Sweden)

    Yoo Kyoung Han

    2017-12-01

    Full Text Available Background: This study aimed to select prescriptions (mixtures of medicinal herbs used in the treatment of bone and joint disorders in Korean medicine, and through the analysis of medicinal herb combination frequencies, select a high-frequency medicinal herb combination group for further experimental and clinical research. Methods: We systematically searched for terms related to bone and joint disorder in the “Dongeuibogam (Dong yibaojian”, a seminal Korean medicine book. We reviewed the results of published papers regarding the effects in bone and joint disorders (especially in osteoporosis, osteomalacia, osteopenia, rheumatoid arthritis, and degenerative arthritis. Results: In total, 34 candidates of a medicinal herb combination for the treatment of bone and joint disorders(CMHCTBJDs and nine candidates of a medicinal herb for the treatment of bone and joint disorders(CMHTBJDs were selected. Conclusion: : The candidates of a medicinal herb combination for the treatment of bone and joint disorders (CMHCTBJDs and candidates of a medicinal herb for the treatment of bone and joint disorders(CMHTBJDs proposed in this study can be useful material for text mining to develop natural products with the effects in BJDs and also it has the potential to reduce the experimental and developmental time period. Keywords: Dongeuibogam (Dong yi bao gian, Text mining, Bone disorder

  14. Emergency department surge: models and practical implications.

    Science.gov (United States)

    Nager, Alan L; Khanna, Kajal

    2009-08-01

    Emergency Department crowding has long been described. Despite the daily challenges of managing emergency department volume and acuity; a surge response during a disaster entails even greater challenges including collaboration, intervention, and resourcefulness to effectively carry out pediatric disaster management. Understanding surge and how to respond with appropriate planning will lead to success. To achieve this, we sought to analyze models of surge; review regional and national data outlining surge challenges and factors that impact surge; and to outline potential solutions. We conducted a systemic review and included articles and documents that best described the theoretical and practical basis of surge response. We organized the systematic review according to the following questions: What are the elements and models that are delineated by the concept of surge? What is the basis for surge response based on regional and national published sources? What are the broad global solutions? What are the major lessons observed that will impact effective surge capacity? Multiple models of surge are described including public health, facility-based and community-based; a 6-tiered response system; and intrinsic or extrinsic surge capacity. In addition, essential components (4 S's of surge response) are described along with regional and national data outlining surge challenges, impacting factors, global solutions, and lesions observed. There are numerous shortcomings regionally and nationally affecting our ability to provide an effective and coordinated surge response. Planning, education, and training will lead to an effective pediatric disaster management response.

  15. Bone marrow oedema assessment by magnetic resonance imaging in rheumatoid arthritis wrist and metacarpophalangeal joints

    DEFF Research Database (Denmark)

    Krabbe, Simon; Eshed, Iris; Pedersen, Susanne Juhl

    2014-01-01

    OBJECTIVE: The aim of this study was to examine the influence of different MRI unit field strengths, coil types and image resolutions on the OMERACT RA MRI scoring system (RAMRIS) of bone marrow oedema (BME) and image quality. METHODS: Forty-one patients and 12 healthy controls participated in th...... resolutions, suggesting that these are equally suited for assessment of BME in RA. However, parameters of image quality and intrareader reliability (favouring 0.6, 1.5 and 3T) should be considered when selecting the MRI acquisition strategy.......OBJECTIVE: The aim of this study was to examine the influence of different MRI unit field strengths, coil types and image resolutions on the OMERACT RA MRI scoring system (RAMRIS) of bone marrow oedema (BME) and image quality. METHODS: Forty-one patients and 12 healthy controls participated...... STIR image sets were anonymized and scored according to RAMRIS and parameters of image quality were measured. RESULTS: The BME sum scores were similar overall when comparing the different MRI units, coil types and voxel sizes, yet significantly higher at the higher resolution of 1.5T Extr compared...

  16. The performance of MRI in detecting subarticular bone erosion of sacroiliac joint in patients with spondyloarthropathy: A comparison with X-ray and CT

    International Nuclear Information System (INIS)

    Hu, Libin; Huang, Zhenguo; Zhang, Xuezhe; Chan, Queenie; Xu, Yanyan; Wang, Guochun; Wang, Wu

    2014-01-01

    Highlights: • MRI 3D-WS-bSSFP sequence has high spatial resolution and short scanning time. • This is the first time this sequence was applied to detect bone erosion of SI joint. • Its performance was compared with other commonly used diagnostic methods. • Result shows that this sequence is better than X-ray and T1W in the detection of bone erosion. • This sequence can be considered an alternative to CT in showing erosion in SpA patients. - Abstract: Objective: To assess the sensitivity and specificity of detecting subarticular bone erosion of sacroiliac (SI) joint in patients with spondyloarthritis (SpA) using MRI three-dimensional water selective balanced steady-state free precession sequence (3D-WS-bSSFP) and T1-weighted (T1W) sequence. Materials and methods: Radiography, CT and MRI of SI joint from 43 SpA patients were retrospectively analyzed. MRI examination sequences include T1W, short tau inversion recovery (STIR) and 3D-WS-bSSFP. Two radiologists, blinded to clinical data, independently determined bone erosion at bilateral sacral and iliac sides of the SI joint on radiography, CT, T1W and 3D-WS-bSSFP respectively. X 2 test was used to compare the sensitivity of detecting bone erosion among different diagnostic methods. Results: Of the 86 sacral and 86 iliac articular surfaces from the 43 cases, radiography, CT, MRI T1W and 3D-WS-bSSFP showed the presence of bone erosion in 40, 74, 50 and 71 articular surfaces respectively. CT and MRI 3D-WS-bSSFP demonstrated similar sensitivity (x 2 = 0.11, P = 0.74), and both were superior to radiography (x 2 = 15.17, P < 0.01 and x 2 = 12.78, P < 0.01, respectively) and T1W (x 2 = 7.26, P < 0.01 and x 2 = 5.62, P < 0.05). Using CT diagnosis as the gold standard, the sensitivity and specificity of detecting bone erosion for MRI 3D-WS-bSSFP and T1W sequences were 91.8%, 96.9%, and 60.8%, 94.9% respectively. Conclusion: MRI 3D-WS-bSSFP sequence is associated with short scanning time, zero ionizing radiation, high

  17. The performance of MRI in detecting subarticular bone erosion of sacroiliac joint in patients with spondyloarthropathy: A comparison with X-ray and CT

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Libin [Department of Radiology, China-Japan Friendship Hospital, Beijing (China); Huang, Zhenguo, E-mail: zhuang680911@163.com [Department of Radiology, China-Japan Friendship Hospital, Beijing (China); Zhang, Xuezhe [Department of Radiology, China-Japan Friendship Hospital, Beijing (China); Chan, Queenie [Philips Healthcare, Hong Kong (China); Xu, Yanyan [Department of Radiology, China-Japan Friendship Hospital, Beijing (China); Wang, Guochun [Department of Rheumatology, China-Japan Friendship Hospital, Beijing (China); Wang, Wu [Department of Radiology, China-Japan Friendship Hospital, Beijing (China)

    2014-11-15

    Highlights: • MRI 3D-WS-bSSFP sequence has high spatial resolution and short scanning time. • This is the first time this sequence was applied to detect bone erosion of SI joint. • Its performance was compared with other commonly used diagnostic methods. • Result shows that this sequence is better than X-ray and T1W in the detection of bone erosion. • This sequence can be considered an alternative to CT in showing erosion in SpA patients. - Abstract: Objective: To assess the sensitivity and specificity of detecting subarticular bone erosion of sacroiliac (SI) joint in patients with spondyloarthritis (SpA) using MRI three-dimensional water selective balanced steady-state free precession sequence (3D-WS-bSSFP) and T1-weighted (T1W) sequence. Materials and methods: Radiography, CT and MRI of SI joint from 43 SpA patients were retrospectively analyzed. MRI examination sequences include T1W, short tau inversion recovery (STIR) and 3D-WS-bSSFP. Two radiologists, blinded to clinical data, independently determined bone erosion at bilateral sacral and iliac sides of the SI joint on radiography, CT, T1W and 3D-WS-bSSFP respectively. X{sup 2} test was used to compare the sensitivity of detecting bone erosion among different diagnostic methods. Results: Of the 86 sacral and 86 iliac articular surfaces from the 43 cases, radiography, CT, MRI T1W and 3D-WS-bSSFP showed the presence of bone erosion in 40, 74, 50 and 71 articular surfaces respectively. CT and MRI 3D-WS-bSSFP demonstrated similar sensitivity (x{sup 2} = 0.11, P = 0.74), and both were superior to radiography (x{sup 2} = 15.17, P < 0.01 and x{sup 2} = 12.78, P < 0.01, respectively) and T1W (x{sup 2} = 7.26, P < 0.01 and x{sup 2} = 5.62, P < 0.05). Using CT diagnosis as the gold standard, the sensitivity and specificity of detecting bone erosion for MRI 3D-WS-bSSFP and T1W sequences were 91.8%, 96.9%, and 60.8%, 94.9% respectively. Conclusion: MRI 3D-WS-bSSFP sequence is associated with short scanning time

  18. In vitro assessment of biomaterial-induced remodeling of subchondral and cancellous bone for the early intervention of joint degeneration with focus on the spinal disc

    Science.gov (United States)

    McCanless, Jonathan D.

    Osteoarthritis-associated pain of the spinal disc, knee, and hip derives from degeneration of cartilagenous tissues in these joints. Traditional therapies have focused on these cartilage (and disc specific nucleus pulposus) changes as a means of treatment through tissue grafting, regenerative synthetic implants, non-regenerative space filling implants, arthroplasty, and arthrodesis. Although such approaches may seem apparent upon initial consideration of joint degeneration, tissue pathology has shown changes in the underlying bone and vascular bed precede the onset of cartilaginous changes. It is hypothesized that these changes precedent joint degeneration and as such may provide a route for early prevention. The current work proposes an injectable biomaterial-based therapy within these subchondral and cancellous bone regions as a means of preventing or reversing osteoarthritis. Two human concentrated platelet releasate-containing alginate hydrogel/beta-tricalcium phosphate composites have been developed for this potential biomaterial application. The undertaking of assessing these materials through bench-, in vitro, and ex vivo work is described herein. These studies showed the capability of the biomaterials to initiate a wound healing response in monocytes, angiogenic and differentiation behavior in immature endothelial cells, and early osteochondral differentiation in mesenchymal stem cells. These cellular activities are associated with fracture healing and endochondral bone formation, demonstrating the potential of the biomaterials to induce osseous and vascular tissue remodeling underlying osteoarthritic joints as a novel therapy for a disease with rapidly growing healthcare costs.

  19. Joint unloading implant modifies subchondral bone trabecular structure in medial knee osteoarthritis: 2-year outcomes of a pilot study using fractal signature analysis

    Directory of Open Access Journals (Sweden)

    Miller LE

    2015-01-01

    Full Text Available Larry E Miller,1,2 Miki Sode,3 Thomas Fuerst,3 Jon E Block2 1Miller Scientific Consulting, Inc., Asheville, NC, USA; 2The Jon Block Group, San Francisco, CA, USA; 3Bioclinica, Newark, CA, USA Background: Knee osteoarthritis (OA is largely attributable to chronic excessive and aberrant joint loading. The purpose of this pilot study was to quantify radiographic changes in subchondral bone after treatment with a minimally invasive joint unloading implant (KineSpring® Knee Implant System.Methods: Nine patients with unilateral medial knee OA resistant to nonsurgical therapy were treated with the KineSpring System and followed for 2 years. Main outcomes included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC pain, function, and stiffness subscores and independent core laboratory determinations of joint space width and fractal signature of the tibial cortex.Results: WOMAC scores, on average, improved by 92% for pain, 91% for function, and 79% for stiffness over the 2-year follow-up period. Joint space width in the medial compartment of the treated knee significantly increased from 0.9 mm at baseline to 3.1 mm at 2 years; joint space width in the medial compartment of the untreated knee was unchanged. Fractal signatures of the vertically oriented trabeculae in the medial compartment decreased by 2.8% in the treated knee and increased by 2.1% in the untreated knee over 2 years. No statistically significant fractal signature changes were observed in the horizontally oriented trabeculae in the medial compartment or in the horizontal or vertical trabeculae of the lateral compartment in the treated knee.Conclusion: Preliminary evidence suggests that the KineSpring System may modify knee OA disease progression by increasing joint space width and improving subchondral bone trabecular integrity, thereby reducing pain and improving joint function. Keywords: disease modification, KineSpring, joint space, pain, trabecular

  20. High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone

    DEFF Research Database (Denmark)

    McQueen, F M; Gao, A; Ostergaard, M

    2007-01-01

    OBJECTIVES: MRI bone oedema has been observed in early and advanced RA and may represent a cellular infiltrate (osteitis) in subchondral bone. We studied MRI scans from RA patients undergoing surgery, seeking to identify regions of bone oedema and examine its histopathological equivalent in resec...

  1. ORGAN PRESERVED RECONSTRUCTIVE OPERATIONS OF THE REPLACEMENT OF DEFECTS OF BONES, FORMING KNEE JOINT

    Directory of Open Access Journals (Sweden)

    A. V. Balberkin

    2011-01-01

    Full Text Available New modular endoprosthesis CITO – MATI was developed and introduced in the clinical practice on the basis of the exploration of results of reconstructive interventions on knee joint area with the usage of different Russian and foreign endoprosthesis. The aim of our work was to compare the functional results and survival of CITO – MATI and Beznoska endoprosthesis. To the moment of the study among 59 patients, who had implanted Beznoska endoprosthesis, 16 (27% were secondly operated due to aseptic instability and the destruction of endoprosthesis components. Functional results of the Beznoska endoprosthesis application were good and excellent in 70,7%, and satisfactory in 29,3%. Among 107 patients with implanted CITO – MATI endoprosthesis 3 (2,8% were operated because of the aseptic instability. The destruction of endoprosthesis components in the observed period of time was not revealed. Functional results of the CITO – MATI endoprosthesis application were good and excellent in 86,6% of cases, and satisfactory in 13,4%. It was revealed, that survival and functional results of the CITO – MATI endoprosthesis application are higher, than those of the Beznoska endoprothesis.

  2. The significance of the intraarticular anesthesia of the tarsometatarsal joint for the diagnosis of lameness in the horse, with special reference to bone spavin

    International Nuclear Information System (INIS)

    Buchner, H.H.F.

    1991-01-01

    Intraarticular anesthesia of the tarsometatarsal joint as a part of the diagnosis of lameness in the horse was evaluated regarding the anatomical features and clinical importance. At first, in 37 hock joints of necropsy material the communications between tarsometatarsal and distal intertarsal joint were studied using simultaneously a corrosion casting technique and a radiographic contrast technique. Radiographically in 25.8 % of the cases a communication could be demonstrated. Using corrosion casting technique, in 9.1 % a wide connection between the joints was evident, whilst in 37.3 % only a low grade connection existed. In 40 hock joints of living horses, communication between the joints were evaluated arthrographically, using Conray 60 R as contrast medium. In 28 % of the tarsal joints communications between tarsometatarsal and distal intertarsal joint could be demonstrated. In 13 horses suffering from bone spavin the effect of the intraarticular tarsometatarsal anesthesia was evaluated: first in a subjective manner on judgement by the veterinarian, second in an objective manner using an optoelectronical locomotion analysis system (SELSPOT II). In 10 of these horses also the BERGE-anesthesia was evaluated. Using the locomotion analysis, a highly significant improvement of lameness was seen in 30 % of the horses following intraarticular tarsometatarsal anesthesia and in 28 % following BERGE-anesthesia. On subjective judgement after intraarticular tarsometatarsal anesthesia, 15.4% of the horses showed a moderate improvement, whilst 38.5% showed a middle graded improvement of the lameness. The necessity of a critical judgement of lameness after diagnostic anesthesias in cases of a minor degree hindlimb lameness has to be pointed out. There was no plain correlation between radiological findings and the results of intraarticular anesthesia. As a general tendency, horses with mild radiological changes do respond to intraarticular anesthesia better. Due to the lack of

  3. [Custom-made implant for complex facial reconstruction: A case of total replacement of temporo-mandibular joint, zygomatic arch and malar bone].

    Science.gov (United States)

    Guillier, D; Moris, V; See, L-A; Girodon, M; Wajszczak, B-L; Zwetyenga, N

    2017-02-01

    Total prosthetic replacement of the temporo-mandibular joint (TMJ) has become a common procedure, but it is usually limited to the TMJ itself. We report about one case of complex prosthetic joint reconstruction extending to the neighbouring bony structures. A 57-year-old patient, operated several times for a cranio-facial fibrous dysplasia, presented with a recurring TMJ ankylosis and a complexe latero-facial bone loss on the right side. We performed a reconstruction procedure including the TMJ, the zygomatic arch and the malar bone by mean of custom made composite prosthesis (chrome-cobalt-molybdenum-titanium and polyethylene). Five years postoperatively, mouth opening, nutrition, pain and oral hygiene were significantly improved. Nowadays technical possibilities allow for complex facial alloplastic reconstructions with good medium term results. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  4. MALDI-TOF MS performance compared to direct examination, culture, and 16S rDNA PCR for the rapid diagnosis of bone and joint infections.

    Science.gov (United States)

    Lallemand, E; Coiffier, G; Arvieux, C; Brillet, E; Guggenbuhl, P; Jolivet-Gougeon, A

    2016-05-01

    The rapid identification of bacterial species involved in bone and joint infections (BJI) is an important element to optimize the diagnosis and care of patients. The aim of this study was to evaluate the usefulness of matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) for the rapid diagnosis of bone infections, directly on synovial fluid (SF) or on crushed osteoarticular samples (CS). From January to October 2013, we prospectively analyzed 111 osteoarticular samples (bone and joint samples, BJS) from 78 patients in care at the University Hospital of Rennes, France. The diagnosis procedure leading to the sample collection was linked to a suspicion of infection, inflammatory disease, arthritis, or for any bone or joint abnormalities. Standard bacteriological diagnosis and molecular biology analysis [16S rRNA polymerase chain reaction (PCR) and sequencing] were conducted. In addition, analysis by MALDI-TOF MS was performed directly on the osteoarticular samples, as soon as the amount allowed. Culture, which remains the gold standard for the diagnosis of BJI, has the highest sensitivity (85.9 %) and remains necessary to test antimicrobial susceptibility. The 16S rDNA PCR results were positive in the group with positive BJI (28.6 %) and negative in the group without infection. Direct examination remains insensitive (31.7 %) but more effective than MALDI-TOF MS directly on the sample (6.3 %). The specificity was 100 % in all cases, except for culture (74.5 %). Bacterial culture remains the gold standard, especially enrichment in blood bottles. Direct analysis of bone samples with MALDI-TOF MS is not useful, possibly due to the low inoculum of BJS.

  5. Characteristics of clinical shoulder research over the last decade: a review of shoulder articles in The Journal of Bone & Joint Surgery from 2004 to 2014.

    Science.gov (United States)

    Gartsman, Gary M; Morris, Brent J; Unger, R Zackary; Laughlin, Mitzi S; Elkousy, Hussein A; Edwards, T Bradley

    2015-03-04

    The purpose of this study was to determine characteristics and trends in published shoulder research over the last decade in a leading orthopaedic journal. We examined all clinical shoulder articles published in The Journal of Bone & Joint Surgery from 2004 to 2014. The number of citations, authorship, academic degrees of the authors, country and institution of origin, topic, level of evidence, positive or nonpositive outcome, and inclusion of validated patient-reported outcome measures were assessed for each article. Shoulder articles that included an author with an advanced research degree (MD [Doctor of Medicine] with a PhD [Doctor of Philosophy] or other advanced degree) increased during the study period (p = 0.047). Level-I, II, and III studies were more likely to have an author with an advanced research degree, and Level-IV studies were more likely to have MDs only (p = 0.03). Overall, there was great variability of outcome measures, with at least thirty-nine different validated or nonvalidated outcome measures reported. Over the last decade, there was an improvement in the level of evidence of shoulder articles published in The Journal of Bone & Joint Surgery that corresponds with recent emphasis on evidence-based medicine. A consensus is needed in shoulder research for more consistent application of validated patient-reported outcome measurement tools. Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.

  6. Joint diseases

    International Nuclear Information System (INIS)

    Weissman, S.D.

    1989-01-01

    The authors discuss how x-ray examination is essential in the diagnosis and evaluation of the arthritides. Most arthritides are first suspected by the clinician, and x-ray evaluation of these entities along with laboratory testing is important for confirmation of the clinical diagnosis and in staging of the disease process. Several arthritides are often diagnosed first by the podiatrist on x-ray evaluation, including pseudogout, ankylosing spondylitis, early rheumatoid arthritis, degenerative joint disease, and tuberculosis of bone. The joint responds to insult in only a limited number of ways that become apparent on x-ray. The soft tissues surrounding the joint, the articulating bones, and alignment of the joint space may all be involved by the arthritic process. On roentgenographic examination, the soft tissues must be examined for edema, masses, calcifications, and atrophy. The articulating bones must be examined for demineralization, erosions, osteophytes, periosteal reaction, cysts and sclerosis

  7. A small punch test technique for characterizing the elastic modulus and fracture behavior of PMMA bone cement used in total joint replacement.

    Science.gov (United States)

    Giddings, V L; Kurtz, S M; Jewett, C W; Foulds, J R; Edidin, A A

    2001-07-01

    Polymethylmethacrylate (PMMA) bone cement is used in total joint replacements to anchor implants to the underlying bone. Establishing and maintaining the integrity of bone cement is thus of critical importance to the long-term outcome of joint replacement surgery. The goal of the present study was to evaluate the suitability of a novel testing technique, the small punch or miniaturized disk bend test, to characterize the elastic modulus and fracture behavior of PMMA. We investigated the hypothesis that the crack initiation behavior of PMMA during the small punch test was sensitive to the test temperature. Miniature disk-shaped specimens, 0.5 mm thick and 6.4 mm in diameter, were prepared from PMMA and Simplex-P bone cement according to manufacturers' instructions. Testing was conducted at ambient and body temperatures, and the effect of test temperature on the elastic modulus and fracture behavior was statistically evaluated using analysis of variance. For both PMMA materials, the test temperature had a significant effect on elastic modulus and crack initiation behavior. At body temperature, the specimens exhibited "ductile" crack initiation, whereas at room temperature "brittle" crack initiation was observed. The small punch test was found to be a sensitive and repeatable test method for evaluating the mechanical behavior of PMMA. In light of the results of this study, future small punch testing should be conducted at body temperature.

  8. EFFECT OF INFLIXIMAB ON DYNAMICS OF FUNCTIONAL CLASS AND RADIOLOGICAL SIGN OF BONE AND CARTILAGINOUS TISSUES ALTERATION OF JOINTS IN PATIENTS WITH DIFFERENT TYPES OF JUVENILE ARTHRITIS

    Directory of Open Access Journals (Sweden)

    E.I. Alexeeva

    2008-01-01

    Full Text Available An objective of this trial was evaluation of effect of treatment with blocker of tumor necrosis factor infliximab on dynamics of functional class and radiological changes of bone and cartilaginous tissue of joints in children with different clinical types of juvenile arthritis (JA. Infliximab was used according to standard scheme on 0, 2, 6 and then every 8 week by intravenous infusion. Mean single dose of infliximab was 6,8 ± 2,3 mg/kg. All children were treated with immunosuppressive agents (ciclosporin in 6% of patients, methotrexate in 60%, ciclosporin combined with methotrexate — 20%, ciclosporin with leflunomide — 5%, leflunomide with methotreate — 4% combined with anti cytokine treatment. 7 children were treated with oral glucocorticoids in mean dose 0,37 mg/kg daily. disorders in joint function and structural changes of joints of different severity (radiological sign were discovered in all patients before starting of treatment with infliximab. Duration of observation was 6 week — 2 years. Authors made a conclusion that treatment with infliximab prevents progressing of bone and cartilaginous destruction in all types of AJ, not depending on intensity of its clinical activity. This medication provides for full functional recovery of joints and elimination of features of disablement in patients with good clinical activity.Key words: children, juvenile arthritis, infliximab, treatment.

  9. Lumbar disc degeneration was not related to spine and hip bone mineral densities in Chinese: facet joint osteoarthritis may confound the association.

    Science.gov (United States)

    Pan, Jianjiang; Lu, Xuan; Yang, Ge; Han, Yongmei; Tong, Xiang; Wang, Yue

    2017-12-01

    A sample of 512 Chinese was studied and we observed that greater disc degeneration on MRI was associated with greater spine DXA BMD. Yet, this association may be confounded by facet joint osteoarthritis. BMD may not be a risk factor for lumbar disc degeneration in Chinese. Evidence suggested that lumbar vertebral bone and intervertebral disc interact with each other in multiple ways. The current paper aims to determine the association between bone mineral density (BMD) and lumbar disc degeneration using a sample of Chinese. We studied 165 patients with back disorders and 347 general subjects from China. All subjects had lumbar spine magnetic resonance (MR) imaging and dual- energy X-ray absorptiometry (DXA) spine BMD studies, and a subset of general subjects had additional hip BMD measurements. On T2-weighted MR images, Pfirrmann score was used to evaluate the degree of lumbar disc degeneration and facet joint osteoarthritis was assessed as none, slight-moderate, and severe. Regression analyses were used to examine the associations between lumbar and hip BMD and disc degeneration, adjusting for age, gender, body mass index (BMI), lumbar region, and facet joint osteoarthritis. Greater facet joint osteoarthritis was associated with greater spine BMD (P osteoarthritis entered the regression model, however, greater spine BMD was associated with greater facet joint osteoarthritis (P  0.05). No statistical association was observed between spine BMD and lumbar disc degeneration in patients with back disorders (P > 0.05), and between hip BMD and disc degeneration in general subjects (P > 0.05). BMD may not be a risk factor for lumbar disc degeneration in Chinese. Facet joint osteoarthritis inflates DXA spine BMD measurements and therefore, may confound the association between spine BMD and disc degeneration.

  10. Bone cysts after osteochondral allograft repair of cartilage defects in goats suggest abnormal interaction between subchondral bone and overlying synovial joint tissues.

    Science.gov (United States)

    Pallante-Kichura, Andrea L; Cory, Esther; Bugbee, William D; Sah, Robert L

    2013-11-01

    The efficacy of osteochondral allografts (OCAs) may be affected by osseous support of the articular cartilage, and thus affected by bone healing and remodeling in the OCA and surrounding host. Bone cysts, and their communication pathways, may be present in various locations after OCA insertion and reflect distinct pathogenic mechanisms. Previously, we analyzed the effect of OCA storage (FRESH, 4°C/14d, 4°C/28d, FROZEN) on cartilage quality in fifteen adult goats after 12months in vivo. The objectives of this study were to further analyze OCAs and contralateral non-operated (Non-Op) CONTROLS from the medial femoral condyle to (1) determine the effect of OCA storage on local subchondral bone (ScB) and trabecular bone (TB) structure, (2) characterize the location and structure of bone cysts and channels, and (3) assess the relationship between cartilage and bone properties. (1) Overall bone structure after OCAs was altered compared to Non-Op, with OCA samples displaying bone cysts, ScB channels, and ScB roughening. ScB BV/TV in FROZEN OCAs was lower than Non-Op and other OCAs. TB BV/TV in FRESH, 4°C/14d, and 4°C/28d OCAs did not vary compared to Non-Op, but BS/TV was lower. (2) OCAs contained "basal" cysts, localized to deeper regions, some "subchondral" cysts, localized near the bone-cartilage interface, and some ScB channels. TB surrounding basal cysts exhibited higher BV/TV than Non-Op. (3) Basal cysts occurred (a) in isolation, (b) with subchondral cysts and ScB channels, (c) with ScB channels, or (d) with subchondral cysts, ScB channels, and ScB erosion. Deterioration of cartilage gross morphology was strongly associated with abnormal μCT bone structure. Evidence of cartilage-bone communication following OCA repair may favor fluid intrusion as a mechanism for subchondral cyst formation, while bone resorption at the graft-host interface without affecting overall bone and cartilage structure may favor bony contusion mechanism for basal cyst formation. These

  11. Pathophysiological mechanisms of Staphylococcus non-aureus bone and joint infection: interspecies homogeneity and specific behaviour of S. pseudintermedius

    Directory of Open Access Journals (Sweden)

    Yousef Maali

    2016-07-01

    Full Text Available Implicated in more than 60% of bone and joint infections (BJIs, Staphylococci have a particular tropism for osteoarticular tissue and lead to difficult-to-treat clinical infections. To date, Staphylococcus aureus internalization in non-professional phagocytic cells (NPPCs is a well-explored virulence mechanism involved in BJI chronicity. Conversely, the pathophysiological pathways associated with Staphylococcus non-aureus (SNA BJIs have scarcely been studied despite their high prevalence. In this study, fifteen reference strains from 15 different SNA species were compared in terms of (i adhesion to human fibronectin based on adhesion microplate assays and (ii internalization ability, intracellular persistence and cytotoxicity based on an in vitro infection model using human osteoblasts. Compared to S. aureus, Staphylococcus pseudintermedius was the only species that significantly adhered to human fibronectin. This species was also associated with high (even superior to S. aureus internalization ability, intracellular persistence and cytotoxicity. These findings were confirmed using a panel of 17 different S. pseudintermedius isolates. Additionally, S. pseudintermedius internalization by osteoblasts was completely abolished in β1 integrin-deficient murine osteoblasts. These results suggest the involvement of β1 integrin in the invasion process, although this mechanism was previously restricted to S. aureus. In summary, our results suggest that internalization into NPPCs is not a classical pathophysiologic mechanism of SNA BJIs. S. pseudintermedius appears to be an exception, and its ability to invade and subsequently induce cytotoxicity in NPPCs could explain its severe and necrotic forms of infection, notably in dogs, which exhibit a high prevalence of S. pseudintermedius infection.

  12. Bone Cysts After Osteochondral Allograft Repair of Cartilage Defects in Goats Suggest Abnormal Interaction Between Subchondral Bone and Overlying Synovial Joint Tissues

    Science.gov (United States)

    Pallante-Kichura, Andrea L.; Cory, Esther; Bugbee, William D.; Sah, Robert L.

    2013-01-01

    The efficacy of osteochondral allografts (OCA) may be affected by osseous support of the articular cartilage, and thus affected by bone healing and remodeling in the OCA and surrounding host. Bone cysts, and their communication pathways, may be present in various locations after OCA insertion and reflect distinct pathogenic mechanisms. Previously, we analyzed the effect of OCA storage (FRESH, 4°C/14d, 4°C/28d, FROZEN) on cartilage quality in fifteen adult goats after 12 months in vivo. The objectives of this study were to further analyze OCA and contralateral non-operated (Non-Op) CONTROLS from the medial femoral condyle to (1) determine the effect of OCA storage on local subchondral (ScB) and trabecular (TB) bone structure, (2) characterize the location and structure of bone cysts and channels, and (3) assess the relationship between cartilage and bone properties. (1) Overall bone structure after OCA was altered compared to Non-Op, with OCA samples displaying bone cysts, ScB channels, and ScB roughening. ScB BV/TV in FROZEN OCA was lower than Non-Op and other OCA. TB BV/TV in FRESH, 4°C/14d, and 4°C/28d OCA did not vary compared to Non-Op, but BS/TV was lower. (2) OCA contained “basal” cysts, localized to deeper regions, some “subchondral” cysts, localized near the bone-cartilage interface, and some ScB channels. TB surrounding basal cysts exhibited higher BV/TV than Non-Op. (3) Basal cysts occurred (a) in isolation, (b) with subchondral cysts and ScB channels, (c) with ScB channels, or (d) with subchondral cysts, ScB channels, and ScB erosion. Deterioration of cartilage gross morphology was strongly associated with abnormal μCT bone structure. Evidence of cartilage-bone communication following OCA repair may favor fluid intrusion as a mechanism for subchondral cyst formation, while bone resorption at the graft-host interface without affecting overall bone and cartilage structure may favor bony contusion mechanism for basal cyst formation. These

  13. A Basis Function Approach to Simulate Storm Surge Events for Coastal Flood Risk Assessment

    Science.gov (United States)

    Wu, Wenyan; Westra, Seth; Leonard, Michael

    2017-04-01

    Storm surge is a significant contributor to flooding in coastal and estuarine regions, especially when it coincides with other flood producing mechanisms, such as extreme rainfall. Therefore, storm surge has always been a research focus in coastal flood risk assessment. Often numerical models have been developed to understand storm surge events for risk assessment (Kumagai et al. 2016; Li et al. 2016; Zhang et al. 2016) (Bastidas et al. 2016; Bilskie et al. 2016; Dalledonne and Mayerle 2016; Haigh et al. 2014; Kodaira et al. 2016; Lapetina and Sheng 2015), and assess how these events may change or evolve in the future (Izuru et al. 2015; Oey and Chou 2016). However, numeric models often require a lot of input information and difficulties arise when there are not sufficient data available (Madsen et al. 2015). Alternative, statistical methods have been used to forecast storm surge based on historical data (Hashemi et al. 2016; Kim et al. 2016) or to examine the long term trend in the change of storm surge events, especially under climate change (Balaguru et al. 2016; Oh et al. 2016; Rueda et al. 2016). In these studies, often the peak of surge events is used, which result in the loss of dynamic information within a tidal cycle or surge event (i.e. a time series of storm surge values). In this study, we propose an alternative basis function (BF) based approach to examine the different attributes (e.g. peak and durations) of storm surge events using historical data. Two simple two-parameter BFs were used: the exponential function and the triangular function. High quality hourly storm surge record from 15 tide gauges around Australia were examined. It was found that there are significantly location and seasonal variability in the peak and duration of storm surge events, which provides additional insights in coastal flood risk. In addition, the simple form of these BFs allows fast simulation of storm surge events and minimises the complexity of joint probability

  14. Technetium-99m hexamethylpropylene amine oxime leucocyte scintigraphy for the diagnosis of bone and joint infections: a retrospective study in 116 patients

    International Nuclear Information System (INIS)

    Devillers, A.; Moisan, A.; Jean, S.; Arvieux, C.; Bourguet, P.

    1995-01-01

    The aim of this study was to evaluate the diagnostic value of technetium-99m hexamethylpropylene amine oxime leucocyte scintigraphy (HMPAO-LS) by means of a retrospective review of 116 patients divided into three groups of bone and joint infection. One hundred and thirty-one LS examinations were performed, and 143 sites analysed. The final diagnosis of infection was based on surgical, histological and bacteriological data and follow-up. Ninety-four suspected localizations were examined in group 1, which included 74 patients with an infection suspected to involve orthopaedic implants. In this group, there were 38 true-positives, 1 false-negative, 49 true-negatives and 6 false-positives. Surgical confirmation was obtained in 34 cases. In group 2 (24 patients with suspected osteomyelitis), there were 27 localizations of which 14 were true-positives and 13 were true-negatives (including seven surgical confirmations). In group 3 (18 patients suspected of septic arthritis) there were eight true-positives, two false-negatives, ten true-negatives and two false-positives. Overall sensitivity of 99m Tc-HMPAO-LS for the detection of bone and joint infection was 95%, with a specificity of 90% (group 1: sensitivity 97%, specificity 89%; group 2: 100% and 100%; group 3: 80% and 83%). It may be concluded that HMPAO-LS is an effective tool for the diagnosis of both bone infection involving implants and chronic osteomyelitis. (orig.)

  15. Stem cell engineered bone with calcium-phosphate coated porous titanium scaffold or silicon hydroxyapatite granules for revision total joint arthroplasty.

    Science.gov (United States)

    García-Gareta, Elena; Hua, Jia; Rayan, Faizal; Blunn, Gordon W

    2014-06-01

    Aseptic loosening in total joint replacements (TJRs) is mainly caused by osteolysis which leads to a reduction of the bone stock necessary for implant fixation in revision TJRs. Our aim was to develop bone tissue-engineered constructs based on scaffolds of clinical relevance in revision TJRs to reconstitute the bone stock at revision operations by using a perfusion bioreactor system (PBRS). The hypothesis was that a PBRS will enhance mesenchymal stem cells (MSCs) proliferation and osteogenic differentiation and will provide an even distribution of MSCs throughout the scaffolds when compared to static cultures. A PBRS was designed and implemented. Scaffolds, silicon substituted hydroxyapatite granules and calcium-phosphate coated porous TiAl6V4 cylinders, were seeded with MSCs and cultured either in static conditions or in the PBRS at 0.75 mL/min. Statistically significant increased cell proliferation and alkaline phosphatase activity was found in samples cultured in the PBRS. Histology revealed a more even cell distribution in the perfused constructs. SEM showed that cells arranged in sheets. Long cytoplasmic processes attached the cells to the scaffolds. We conclude that a novel tissue engineering approach to address the issue of poor bone stock at revision operations is feasible by using a PBRS.

  16. The Influence of Oblique Angle Forced Exercise in Surgically Destabilized Stifle Joints Is Synergistic with Bone, but Antagonistic with Cartilage in an Ovine Model of Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Rachel J. Hill

    2017-01-01

    Full Text Available Large animal models of osteoarthritis are a necessary testing ground for FDA approval of human medicine applications. Sheep models have advantages over other available large animals, but development and progression of osteoarthritis in sheep is exceedingly slow, which handicaps progress in development of potential treatments. We combined oblique angle forced exercise to increase stress on the stifle, with surgical destabilization to hasten the development of osteoarthritis in ewes. Methods for early detection of clinical signs included radiography, urine, and serum biomarker assays and gait analysis and ex vivo we used microcomputed tomography and macroscopic joint analysis. Our model was able to produce clinically detectable signs of osteoarthritis in a relatively short period (14 weeks. Changes in bone were highly correlated between microcomputed tomography and radiographic analysis and changes in cartilage correlated well between urinary glycosaminoglycan levels and serum aggrecanase analyses. Exercise improved the negative effects of destabilization in bone but exacerbated the negative effects of destabilization in cartilage. These observations suggest that we may need to consider treatments for bone and cartilage separately. These results represent an improved large animal model of osteoarthritis with rapid onset of disease and superior detection of bone and soft tissue changes.

  17. Reconnaissance level study Mississippi storm surge barrier

    NARCIS (Netherlands)

    Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.

    2012-01-01

    This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further

  18. Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis.

    Science.gov (United States)

    Roberts, B C; Solomon, L B; Mercer, G; Reynolds, K J; Thewlis, D; Perilli, E

    2018-04-01

    To study, in end-stage knee osteoarthritis (OA) patients, relationships between indices of in vivo dynamic knee joint loads obtained pre-operatively using gait analysis, static knee alignment, and the subchondral trabecular bone (STB) microarchitecture of their excised tibial plateau quantified with 3D micro-CT. Twenty-five knee OA patients scheduled for total knee arthroplasty underwent pre-operative gait analysis. Mechanical axis deviation (MAD) was determined radiographically. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four subregions (anteromedial, posteromedial, anterolateral, posterolateral). Regional differences in STB microarchitecture and relationships between joint loading and microarchitecture were examined. STB microarchitecture differed among subregions (P knee adduction moment (KAM) and internal rotation moment (|r|-range: 0.54-0.74). When controlling for walking speed, KAM and MAD, the ERM explained additional 11-30% of the variations in anteromedial BV/TV and medial-to-lateral BV/TV ratio (R 2  = 0.59, R 2  = 0.69, P knee joint loading indices in end-stage knee OA patients. Particularly, anteromedial BV/TV correlates strongest with ERM, whereas medial-to-lateral BV/TV ratio correlates strongest with indicators of medial-to-lateral joint loading (MAD, KAM) and rotational moments. However, associations with ERM should be interpreted with caution. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  19. The effect of CT dose on glenohumeral joint congruency measurements using 3D reconstructed patient-specific bone models

    International Nuclear Information System (INIS)

    Lalone, Emily A; Fox, Anne-Marie V; Jenkyn, Thomas R; King, Graham J W; Johnson, James A; Peters, Terry M; Kedgley, Angela E; Athwal, George S

    2011-01-01

    The study of joint congruency at the glenohumeral joint of the shoulder using computed tomography (CT) and three-dimensional (3D) reconstructions of joint surfaces is an area of significant clinical interest. However, ionizing radiation delivered to patients during CT examinations is much higher than other types of radiological imaging. The shoulder represents a significant challenge for this modality as it is adjacent to the thyroid gland and breast tissue. The objective of this study was to determine the optimal CT scanning techniques that would minimize radiation dose while accurately quantifying joint congruency of the shoulder. The results suggest that only one-tenth of the standard applied total current (mA) and a pitch ratio of 1.375:1 was necessary to produce joint congruency values consistent with that of the higher dose scans. Using the CT scanning techniques examined in this study, the effective dose applied to the shoulder to quantify joint congruency was reduced by 88.9% compared to standard clinical CT imaging techniques.

  20. Storm Surge Modeling of Typhoon Haiyan at the Naval Oceanographic Office Using Delft3D

    Science.gov (United States)

    Gilligan, M. J.; Lovering, J. L.

    2016-02-01

    The Naval Oceanographic Office provides estimates of the rise in sea level along the coast due to storm surge associated with tropical cyclones, typhoons, and hurricanes. Storm surge modeling and prediction helps the US Navy by providing a threat assessment tool to help protect Navy assets and provide support for humanitarian assistance/disaster relief efforts. Recent advancements in our modeling capabilities include the use of the Delft3D modeling suite as part of a Naval Research Laboratory (NRL) developed Coastal Surge Inundation Prediction System (CSIPS). Model simulations were performed on Typhoon Haiyan, which made landfall in the Philippines in November 2013. Comparisons of model simulations using forecast and hindcast track data highlight the importance of accurate storm track information for storm surge predictions. Model runs using the forecast track prediction and hindcast track information give maximum storm surge elevations of 4 meters and 6.1 meters, respectively. Model results for the hindcast simulation were compared with data published by the JSCE-PICE Joint survey for locations in San Pedro Bay (SPB) and on the Eastern Samar Peninsula (ESP). In SPB, where wind-induced set-up predominates, the model run using the forecast track predicted surge within 2 meters in 38% of survey locations and within 3 meters in 59% of the locations. When the hindcast track was used, the model predicted within 2 meters in 77% of the locations and within 3 meters in 95% of the locations. The model was unable to predict the high surge reported along the ESP produced by infragravity wave-induced set-up, which is not simulated in the model. Additional modeling capabilities incorporating infragravity waves are required to predict storm surge accurately along open coasts with steep bathymetric slopes, such as those seen in island arcs.

  1. [Case-control study on bone setting manipulation for the treatment of over degree II supination-eversion fractures of ankle joint].

    Science.gov (United States)

    Qi, Yue-Feng; Chen, Fa-Lin; Bao, Shu-Ren; Li, Cheng-Huan; Zhao, Xing-Wei; Liu, Shi-Ming; Chen, Wen-Xue; Li, Ye; Wang, Peng

    2012-08-01

    To explore therapeutic effects of bone setting manipulation for the treatment of over degree II supination-eversion fractures of ankle,and analyze manipulative reduction mechanism. From 2005 to 2008, 95 patients with over degree II supination-eversion fractures of ankle were treated respectively by manipulation and operation. There were 43 cases [11 males and 32 females with an average age of (44.95 +/- 12.65) years] in manipulation group, and 2 cases were degree II, 11 cases were degree III, and 30 cases were degree IV. There were 52 cases [21 males and 31 females with an average age of (39.96 +/- 13.28) years] in operative group,and 6 cases were degree II, 18 cases were degree III, and 28 cases were degree IV. Bone setting manipulation and hard splint external fixation were applied to manipulative group. Operative reduction internal fixation was performed in operative group. X-ray was used to evaluate reduction of fracture before and after treatment, 2 months after treatment. Ankle joint function was evaluated according to Olerud-Molander scoring system after 6 months treatment. All patients were followed up with good reduction. Three cases occurred wound complication in operative group, but not in manipulative group. In manipulation group, 19 cases got excellent results, 20 cases good and 4 cases fair; while in operative group, 30 cases got excellent results, 20 cases good and 2 cases poor. There were no significant differences in fracture reduction and ankle joint function recovery between two groups (P > 0.05). Efficacy of operative treatment was better than that of manipulative treatment at degree IV fracture (P ankle joint fractures, which has advantages of simple and safe operation, reliable efficacy. For ankle join fracture at degree IV, manipulative reduction should be adopted earlier, and operative treatment also necessary

  2. MRI assessment of bone marrow oedema in the sacroiliac joints of patients with spondyloarthritis: is the SPAIR T2w technique comparable to STIR?

    International Nuclear Information System (INIS)

    Faeda Dalto, Vitor; Nogueira-Barbosa, Marcello Henrique; Assad, Rodrigo Luppino; Crema, Michel Daoud; Louzada-Junior, Paulo

    2017-01-01

    To compare short tau inversion-recovery (STIR) with another fat saturation method in the assessment of sacroiliac joint inflammation. This prospective cross-sectional study comprised 76 spondyloarthritis (SpA) patients who underwent magnetic resonance imaging of the sacroiliac joints in a 1.5-T scanner, using STIR, spectral attenuated inversion recovery (SPAIR) T2w and spectral presaturation with inversion recovery (SPIR) T1w post-contrast sequences. Two independent readers (R1 and R2) assessed the images using the Spondyloarthritis Research Consortium of Canada (SPARCC) score. We assessed agreement of the SPARCC scores for SPAIR T2w and STIR with that for T1 SPIR post-contrast (reference standard) using the St. Laurent coefficient. We evaluated each sequence using the concordance correlation coefficient (CCC). We observed a strong agreement between STIR and SPAIR T2w sequences. Lin's CCC was 0.94 for R1 and 0.84 for R2 for STIR and 0.94 for R1 and 0.84 for R2 for SPAIR. The interobserver evaluation revealed a good CCC of 0.79 for SPAIR and 0.78 for STIR. STIR technique and SPAIR T2w sequence showed high agreement in the evaluation of sacroiliac joint subchondral bone marrow oedema in patients with SpA. SPAIR T2w may be an alternative to the STIR sequence for this purpose. (orig.)

  3. MRI assessment of bone marrow oedema in the sacroiliac joints of patients with spondyloarthritis: is the SPAIR T2w technique comparable to STIR?

    Energy Technology Data Exchange (ETDEWEB)

    Faeda Dalto, Vitor; Nogueira-Barbosa, Marcello Henrique [University of Sao Paulo, Division of Radiology, Department of Internal Medicine, Ribeirao Preto Medical School, Ribeirao Preto, SP (Brazil); Assad, Rodrigo Luppino [University of Sao Paulo, Division of Clinical Imunology, Department of Internal Medicine, Ribeirao Preto Medical School, Ribeirao Preto, SP (Brazil); Crema, Michel Daoud [Hopital Saint-Antoine, Universite Paris VI, Service de Radiologie, Paris (France); Boston University School of Medicine, Department of Radiology, Quantitative Imaging Center, Boston, MA (United States); Hospital do Coracao (HCor) e Teleimagem, Departamento de Radiologia, Sao Paulo, SP (Brazil); Louzada-Junior, Paulo [University of Sao Paulo, Department of Internal Medicine, Ribeirao Preto Medical School, Ribeirao Preto, SP (Brazil)

    2017-09-15

    To compare short tau inversion-recovery (STIR) with another fat saturation method in the assessment of sacroiliac joint inflammation. This prospective cross-sectional study comprised 76 spondyloarthritis (SpA) patients who underwent magnetic resonance imaging of the sacroiliac joints in a 1.5-T scanner, using STIR, spectral attenuated inversion recovery (SPAIR) T2w and spectral presaturation with inversion recovery (SPIR) T1w post-contrast sequences. Two independent readers (R1 and R2) assessed the images using the Spondyloarthritis Research Consortium of Canada (SPARCC) score. We assessed agreement of the SPARCC scores for SPAIR T2w and STIR with that for T1 SPIR post-contrast (reference standard) using the St. Laurent coefficient. We evaluated each sequence using the concordance correlation coefficient (CCC). We observed a strong agreement between STIR and SPAIR T2w sequences. Lin's CCC was 0.94 for R1 and 0.84 for R2 for STIR and 0.94 for R1 and 0.84 for R2 for SPAIR. The interobserver evaluation revealed a good CCC of 0.79 for SPAIR and 0.78 for STIR. STIR technique and SPAIR T2w sequence showed high agreement in the evaluation of sacroiliac joint subchondral bone marrow oedema in patients with SpA. SPAIR T2w may be an alternative to the STIR sequence for this purpose. (orig.)

  4. MRI assessment of bone marrow oedema in the sacroiliac joints of patients with spondyloarthritis: is the SPAIR T2w technique comparable to STIR?

    Science.gov (United States)

    Dalto, Vitor Faeda; Assad, Rodrigo Luppino; Crema, Michel Daoud; Louzada-Junior, Paulo; Nogueira-Barbosa, Marcello Henrique

    2017-09-01

    To compare short tau inversion-recovery (STIR) with another fat saturation method in the assessment of sacroiliac joint inflammation. This prospective cross-sectional study comprised 76 spondyloarthritis (SpA) patients who underwent magnetic resonance imaging of the sacroiliac joints in a 1.5-T scanner, using STIR, spectral attenuated inversion recovery (SPAIR) T2w and spectral presaturation with inversion recovery (SPIR) T1w post-contrast sequences. Two independent readers (R1 and R2) assessed the images using the Spondyloarthritis Research Consortium of Canada (SPARCC) score. We assessed agreement of the SPARCC scores for SPAIR T2w and STIR with that for T1 SPIR post-contrast (reference standard) using the St. Laurent coefficient. We evaluated each sequence using the concordance correlation coefficient (CCC). We observed a strong agreement between STIR and SPAIR T2w sequences. Lin's CCC was 0.94 for R1 and 0.84 for R2 for STIR and 0.94 for R1 and 0.84 for R2 for SPAIR. The interobserver evaluation revealed a good CCC of 0.79 for SPAIR and 0.78 for STIR. STIR technique and SPAIR T2w sequence showed high agreement in the evaluation of sacroiliac joint subchondral bone marrow oedema in patients with SpA. SPAIR T2w may be an alternative to the STIR sequence for this purpose. • There are no studies evaluating which fat saturation technique should be used. • SPAIR T2w may be an alternative to STIR for sacroiliac joint evaluation. • The study will lead to changes in guidelines for spondyloarthritis.

  5. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Smeulers, J.P.M.; Slot, H.J.; Meulendijks, D.

    2011-01-01

    Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

  6. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Slot, H.J.; Meulendijks, D.; Smeulers, J.P.M.

    2009-01-01

    Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

  7. Pain and Opioid use Outcomes Following Minimally Invasive Sacroiliac Joint Fusion with Decortication and Bone Grafting: The Evolusion Clinical Trial.

    Science.gov (United States)

    Araghi, Ali; Woodruff, Robert; Colle, Kyle; Boone, Christopher; Ingham, Lisa; Tomeh, Antoine; Fielding, Louis C

    2017-01-01

    This report documents six-month results of the first 50 patients treated in a prospective, multi-center study of a minimally invasive (MI) sacroiliac (SI) joint fusion system. This cohort includes 50 patients who had MI SI joint fusion surgery and completed 6 month follow-up. Average age at baseline was 61.5, 58% were female, and SI joint-related pain duration was ≥2yrs in 54.0% of patients. Visual Analog Scale (VAS) SI joint pain, Oswestry Disability Index (ODI), quality of life and opioid use were assessed preoperatively and at 6 months. At 6 months, mean VAS pain demonstrated a significant reduction from 76.2 at baseline to 35.1 (54% reduction, p<0.0001), with 72% of patients attaining the minimal clinically important difference (MCID, ≥20 point improvement). Mean ODI improved from 55.5 to 35.3 at 6 months (p < 0.001), with 56% of patients achieving the MCID (≥15 point improvement). Prior to surgery 33/50 (66%) of patients were taking opioids, but by 6 months the number of patients taking opioids had decreased by 55% to 15/50 (30%). Few procedural complications were reported. Two procedure-related events required hospitalization: a revision procedure (2%) for nerve impingement and one case of ongoing low back pain. Analysis of patients treated with MI SI joint fusion using the SImmetry System demonstrated that the procedure can be performed safely and results in significant improvements in pain, disability, and opioid use at 6 months. Longer term follow-up in this study will determine whether these improvements are durable, as well as the associated radiographic fusion rates.

  8. Analysis of Storm Surge in Hong Kong

    Science.gov (United States)

    Kao, W. H.

    2017-12-01

    A storm surge is a type of coastal flood that is caused by low-pressure systems such as tropical cyclones. Storm surges caused by tropical cyclones can be very powerful and damaging, as they can flood coastal areas, and even destroy infrastructure in serious cases. Some serious cases of storm surges leading to more than thousands of deaths include Hurricane Katrina (2005) in New Orleans and Typhoon Haiyan (2013) in Philippines. Hong Kong is a coastal city that is prone to tropical cyclones, having an average of 5-6 tropical cyclones entering 500km range of Hong Kong per year. Storm surges have seriously damaged Hong Kong in the past, causing more than 100 deaths by Typhoon Wanda (1962), and leading to serious damage to Tai O and Cheung Chau by Typhoon Hagupit (2008). To prevent economic damage and casualties from storm surges, accurately predicting the height of storm surges and giving timely warnings to citizens is very important. In this project, I will be analyzing how different factors affect the height of storm surge, mainly using data from Hong Kong. These factors include the windspeed in Hong Kong, the atmospheric pressure in Hong Kong, the moon phase, the wind direction, the intensity of the tropical cyclone, distance between the tropical cyclone and Hong Kong, the direction of the tropical cyclone relative to Hong Kong, the speed of movement of the tropical cyclone and more. My findings will also be compared with cases from other places, to see if my findings also apply for other places.

  9. MRI of the temporo-mandibular joint: which sequence is best suited to assess the cortical bone of the mandibular condyle? A cadaveric study using micro-CT as the standard of reference.

    Science.gov (United States)

    Karlo, Christoph A; Patcas, Raphael; Kau, Thomas; Watzal, Helmut; Signorelli, Luca; Müller, Lukas; Ullrich, Oliver; Luder, Hans-Ulrich; Kellenberger, Christian J

    2012-07-01

    To determine the best suited sagittal MRI sequence out of a standard temporo-mandibular joint (TMJ) imaging protocol for the assessment of the cortical bone of the mandibular condyles of cadaveric specimens using micro-CT as the standard of reference. Sixteen TMJs in 8 human cadaveric heads (mean age, 81 years) were examined by MRI. Upon all sagittal sequences, two observers measured the cortical bone thickness (CBT) of the anterior, superior and posterior portions of the mandibular condyles (i.e. objective analysis), and assessed for the presence of cortical bone thinning, erosions or surface irregularities as well as subcortical bone cysts and anterior osteophytes (i.e. subjective analysis). Micro-CT of the condyles was performed to serve as the standard of reference for statistical analysis. Inter-observer agreements for objective (r = 0.83-0.99, P < 0.01) and subjective (κ = 0.67-0.88) analyses were very good. Mean CBT measurements were most accurate, and cortical bone thinning, erosions, surface irregularities and subcortical bone cysts were best depicted on the 3D fast spoiled gradient echo recalled sequence (3D FSPGR). The most reliable MRI sequence to assess the cortical bone of the mandibular condyles on sagittal imaging planes is the 3D FSPGR sequence. MRI may be used to assess the cortical bone of the TMJ. • Depiction of cortical bone is best on 3D FSPGR sequences. • MRI can assess treatment response in patients with TMJ abnormalities.

  10. Simulated radiographic bone and joint modeling from 3D ankle MRI: feasibility and comparison with radiographs and 2D MRI

    Energy Technology Data Exchange (ETDEWEB)

    Nordeck, Shaun M. [University of Texas Southwestern Medical College, Dallas, TX (United States); University of Texas Southwestern Medical Center, Musculoskeletal Radiology, Dallas, TX (United States); Koerper, Conrad E.; Adler, Aaron [University of Texas Southwestern Medical College, Dallas, TX (United States); Malhotra, Vidur; Xi, Yin [University of Texas Southwestern Medical Center, Musculoskeletal Radiology, Dallas, TX (United States); Liu, George T. [University of Texas Southwestern Medical Center, Orthopaedic Surgery, Dallas, TX (United States); Chhabra, Avneesh [University of Texas Southwestern Medical Center, Musculoskeletal Radiology, Dallas, TX (United States); University of Texas Southwestern Medical Center, Orthopaedic Surgery, Dallas, TX (United States)

    2017-05-15

    The purpose of this work is to simulate radiographs from isotropic 3D MRI data, compare relationship of angle and joint space measurements on simulated radiographs with corresponding 2D MRIs and real radiographs (XR), and compare measurement times among the three modalities. Twenty-four consecutive ankles were included, eight males and 16 females, with a mean age of 46 years. Segmented joint models simulating radiographs were created from 3D MRI data sets. Three readers independently performed blinded angle and joint space measurements on the models, corresponding 2D MRIs, and XRs at two time points. Linear mixed models and the intraclass correlation coefficient (ICC) was ascertained, with p values less than 0.05 considered significant. Simulated radiograph models were successfully created in all cases. Good agreement (ICC > 0.65) was noted among all readers across all modalities and among most measurements. Absolute measurement values differed between modalities. Measurement time was significantly greater (p < 0.05) on 2D versus simulated radiographs for most measurements and on XR versus simulated radiographs (p < 0.05) for nearly half the measurements. Simulated radiographs can be successfully generated from 3D MRI data; however, measurements differ. Good inter-reader and moderate-to-good intra-reader reliability was observed and measurements obtained on simulated radiograph models took significantly less time compared to measurements with 2D and generally less time than XR. (orig.)

  11. Volume-based characterization of postocclusion surge.

    Science.gov (United States)

    Zacharias, Jaime; Zacharias, Sergio

    2005-10-01

    To propose an alternative method to characterize postocclusion surge using a collapsible artificial anterior chamber to replace the currently used rigid anterior chamber model. Fundación Oftamológica Los Andes, Santiago, Chile. The distal end of a phacoemulsification handpiece was placed inside a compliant artificial anterior chamber. Digital recordings of chamber pressure, chamber volume, inflow, and outflow were performed during occlusion break of the phacoemulsification tip. The occlusion break profile of 2 different consoles was compared. Occlusion break while using a rigid anterior chamber model produced a simultaneous increase of chamber inflow and outflow. In the rigid chamber model, pressure decreased sharply, reaching negative pressure values. Alternatively, with the collapsible chamber model, a delay was observed in the inflow that occurs to compensate the outflow surge. Also, the chamber pressure drop was smaller in magnitude, never undershooting below atmospheric pressure into negative values. Using 500 mm Hg as vacuum limit, the Infiniti System (Alcon) performed better that the Legacy (Alcon), showing an 18% reduction in peak volume variation. The collapsible anterior chamber model provides a more realistic representation of the postocclusion surge events that occur in the real eye during cataract surgery. Peak volume fluctuation (mL), half volume recovery time(s), and volume fluctuation integral value (mL x s) are proposed as realistic indicators to characterize the postocclusion surge performance. These indicators show that the Infiniti System has a better postocclusion surge behavior than the Legacy System.

  12. Joint Replacement (Finger and Wrist Joints)

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy Joint Replacement Email to a friend * required fields ...

  13. Acromioclavicular joint dislocation: a Dog Bone button fixation alone versus Dog Bone button fixation augmented with acromioclavicular repair-a finite element analysis study.

    Science.gov (United States)

    Sumanont, Sermsak; Nopamassiri, Supachoke; Boonrod, Artit; Apiwatanakul, Punyawat; Boonrod, Arunnit; Phornphutkul, Chanakarn

    2018-03-20

    Suspension suture button fixation was frequently used to treat acromioclavicular joint (ACJ) dislocation. However, there were many studies reporting about complications and residual horizontal instability after fixation. Our study compared the stability of ACJ after fixation between coracoclavicular (CC) fixation alone and CC fixation combined with ACJ repair by using finite element analysis (FEA). A finite element model was created by using CT images from the normal shoulder. The model 1 was CC fixation with suture button alone, and the model 2 was CC fixation with suture button combined with ACJ repair. Three different forces (50, 100, 200 N) applied to the model in three planes; inferior, anterior and posterior direction load to the acromion. The von Mises stress of the implants and deformation at ACJs was recorded. The ACJ repair in the model 2 could reduce the peak stress on the implant after applying the loading forces to the acromion which the ACJ repair could reduce the peak stress of the FiberWire at suture button about 90% when compared to model 1. And, the ACJ repair could reduce the deformation of the ACJ after applying the loading forces to the acromion in both vertical and horizontal planes. This FEA supports that the high-grade injuries of the ACJ should be treated with CC fixation combined with ACJ repair because this technique provides excellent stability in both vertical and horizontal planes and reduces stress to the suture button.

  14. Adaptive mesh refinement for storm surge

    KAUST Repository

    Mandli, Kyle T.; Dawson, Clint N.

    2014-01-01

    An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

  15. Adaptive mesh refinement for storm surge

    KAUST Repository

    Mandli, Kyle T.

    2014-03-01

    An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

  16. Detection of bone erosions in rheumatoid arthritis wrist joints with magnetic resonance imaging, computed tomography and radiography

    DEFF Research Database (Denmark)

    Døhn, Uffe Møller; Ejbjerg, Bo J; Hasselquist, Maria

    2008-01-01

    , specificity and accuracy (concordance) of MRI for detecting erosions were 61%, 93% and 77%, respectively, while the respective values were 24%, 99% and 63% for radiography. The intramodality agreements when measuring erosion volumes were high for both CT and MRI (Spearman correlation coefficients 0.92 and 0...... sensitivity and good specificity and accuracy for detection of erosions in rheumatoid arthritis and healthy wrist bones, while radiography showed very low sensitivity. The tested volumetric method was highly reproducible and correlated to scores of erosions....... measuring volumes of erosions on CT and MRI is reproducible and correlated to semiquantitative assessments (scores) of erosions on CT, MRI and radiography. METHODS: Seventeen patients with rheumatoid arthritis and four healthy control individuals underwent CT, MRI and radiography of one wrist, performed...

  17. Exercising Tactically for Taming Postmeal Glucose Surges.

    Science.gov (United States)

    Chacko, Elsamma

    2016-01-01

    This review seeks to synthesize data on the timing, intensity, and duration of exercise found scattered over some 39 studies spanning 3+ decades into optimal exercise conditions for controlling postmeal glucose surges. The results show that a light aerobic exercise for 60 min or moderate activity for 20-30 min starting 30 min after meal can efficiently blunt the glucose surge, with minimal risk of hypoglycemia. Exercising at other times could lead to glucose elevation caused by counterregulation. Adding a short bout of resistance exercise of moderate intensity (60%-80%  VO2max) to the aerobic activity, 2 or 3 times a week as recommended by the current guidelines, may also help with the lowering of glucose surges. On the other hand, high-intensity exercise (>80%  VO2max) causes wide glucose fluctuations and its feasibility and efficacy for glucose regulation remain to be ascertained. Promoting the kind of physical activity that best counters postmeal hyperglycemia is crucial because hundreds of millions of diabetes patients living in developing countries and in the pockets of poverty in the West must do without medicines, supplies, and special diets. Physical activity is the one tool they may readily utilize to tame postmeal glucose surges. Exercising in this manner does not violate any of the current guidelines, which encourage exercise any time.

  18. Exercising Tactically for Taming Postmeal Glucose Surges

    Directory of Open Access Journals (Sweden)

    Elsamma Chacko

    2016-01-01

    Full Text Available This review seeks to synthesize data on the timing, intensity, and duration of exercise found scattered over some 39 studies spanning 3+ decades into optimal exercise conditions for controlling postmeal glucose surges. The results show that a light aerobic exercise for 60 min or moderate activity for 20–30 min starting 30 min after meal can efficiently blunt the glucose surge, with minimal risk of hypoglycemia. Exercising at other times could lead to glucose elevation caused by counterregulation. Adding a short bout of resistance exercise of moderate intensity (60%–80%  VO2max to the aerobic activity, 2 or 3 times a week as recommended by the current guidelines, may also help with the lowering of glucose surges. On the other hand, high-intensity exercise (>80%  VO2max causes wide glucose fluctuations and its feasibility and efficacy for glucose regulation remain to be ascertained. Promoting the kind of physical activity that best counters postmeal hyperglycemia is crucial because hundreds of millions of diabetes patients living in developing countries and in the pockets of poverty in the West must do without medicines, supplies, and special diets. Physical activity is the one tool they may readily utilize to tame postmeal glucose surges. Exercising in this manner does not violate any of the current guidelines, which encourage exercise any time.

  19. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    is of interest to study compression-system surge to understand its dynamics in order ... Internal problems like compressor going into rotating stall, resulting in loss of ... of water column, was used for mass-flow measurement at the impeller entry.

  20. Positive feedback stabilization of centrifugal compressor surge

    NARCIS (Netherlands)

    Willems, Frank; Heemels, W.P.M.H.; de Jager, Bram; Stoorvogel, Antonie Arij

    Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

  1. Positive feedback stabilization of centrifugal compressor surge

    NARCIS (Netherlands)

    Willems, F.P.T.; Heemels, W.P.M.H.; Jager, de A.G.; Stoorvogel, A.A.

    2002-01-01

    Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

  2. MRI of the temporo-mandibular joint: which sequence is best suited to assess the cortical bone of the mandibular condyle? A cadaveric study using micro-CT as the standard of reference

    International Nuclear Information System (INIS)

    Karlo, Christoph A.; Patcas, Raphael; Signorelli, Luca; Mueller, Lukas; Kau, Thomas; Watzal, Helmut; Kellenberger, Christian J.; Ullrich, Oliver; Luder, Hans-Ulrich

    2012-01-01

    To determine the best suited sagittal MRI sequence out of a standard temporo-mandibular joint (TMJ) imaging protocol for the assessment of the cortical bone of the mandibular condyles of cadaveric specimens using micro-CT as the standard of reference. Sixteen TMJs in 8 human cadaveric heads (mean age, 81 years) were examined by MRI. Upon all sagittal sequences, two observers measured the cortical bone thickness (CBT) of the anterior, superior and posterior portions of the mandibular condyles (i.e. objective analysis), and assessed for the presence of cortical bone thinning, erosions or surface irregularities as well as subcortical bone cysts and anterior osteophytes (i.e. subjective analysis). Micro-CT of the condyles was performed to serve as the standard of reference for statistical analysis. Inter-observer agreements for objective (r = 0.83-0.99, P < 0.01) and subjective (κ = 0.67-0.88) analyses were very good. Mean CBT measurements were most accurate, and cortical bone thinning, erosions, surface irregularities and subcortical bone cysts were best depicted on the 3D fast spoiled gradient echo recalled sequence (3D FSPGR). The most reliable MRI sequence to assess the cortical bone of the mandibular condyles on sagittal imaging planes is the 3D FSPGR sequence. (orig.)

  3. MRI of the temporo-mandibular joint: which sequence is best suited to assess the cortical bone of the mandibular condyle? A cadaveric study using micro-CT as the standard of reference

    Energy Technology Data Exchange (ETDEWEB)

    Karlo, Christoph A. [University Hospital Zurich, Department of Diagnostic and Interventional Radiology, Zurich (Switzerland); University Children' s Hospital Zurich, Department of Diagnostic Imaging, Zurich (Switzerland); Patcas, Raphael; Signorelli, Luca; Mueller, Lukas [University of Zurich, Clinic for Orthodontics and Pediatric Dentistry, Center of Dental Medicine, Zurich (Switzerland); Kau, Thomas; Watzal, Helmut; Kellenberger, Christian J. [University Children' s Hospital Zurich, Department of Diagnostic Imaging, Zurich (Switzerland); Ullrich, Oliver [University of Zurich, Institute of Anatomy, Faculty of Medicine, Zurich (Switzerland); Luder, Hans-Ulrich [University of Zurich, Section of Orofacial Structures and Development, Center of Dental Medicine, Zurich (Switzerland)

    2012-07-15

    To determine the best suited sagittal MRI sequence out of a standard temporo-mandibular joint (TMJ) imaging protocol for the assessment of the cortical bone of the mandibular condyles of cadaveric specimens using micro-CT as the standard of reference. Sixteen TMJs in 8 human cadaveric heads (mean age, 81 years) were examined by MRI. Upon all sagittal sequences, two observers measured the cortical bone thickness (CBT) of the anterior, superior and posterior portions of the mandibular condyles (i.e. objective analysis), and assessed for the presence of cortical bone thinning, erosions or surface irregularities as well as subcortical bone cysts and anterior osteophytes (i.e. subjective analysis). Micro-CT of the condyles was performed to serve as the standard of reference for statistical analysis. Inter-observer agreements for objective (r = 0.83-0.99, P < 0.01) and subjective ({kappa} = 0.67-0.88) analyses were very good. Mean CBT measurements were most accurate, and cortical bone thinning, erosions, surface irregularities and subcortical bone cysts were best depicted on the 3D fast spoiled gradient echo recalled sequence (3D FSPGR). The most reliable MRI sequence to assess the cortical bone of the mandibular condyles on sagittal imaging planes is the 3D FSPGR sequence. (orig.)

  4. Effect of piping systems on surge in centrifugal compressors

    International Nuclear Information System (INIS)

    Tamaki, Hideaki

    2008-01-01

    There is a possibility that the exchange of the piping system may change the surge characteristic of a compressor. The piping system of a plant is not always the same as that of a test site. Then it is important to evaluate the effect of piping systems on surge characteristics in centrifugal compressors. Several turbochargers combined with different piping systems were tested. The lumped parameter model which was simplified to be solved easily was applied for the prediction of surge point. Surge lines were calculated with the linearlized lumped parameter model. The difference between the test and calculated results was within 10 %. Trajectory of surge cycle was also examined by solving the lumped parameter model. Mild surge and deep surge were successfully predicted. This study confirmed that the lumped parameter model was a very useful tool to predict the effect of piping systems on surge characteristics in centrifugal compressors, even though that was a simple model

  5. 48 CFR 252.217-7001 - Surge option.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Surge option. 252.217-7001... Clauses 252.217-7001 Surge option. As prescribed in 217.208-70(b), use the following clause: Surge Option (AUG 1992) (a) General. The Government has the option to— (1) Increase the quantity of supplies or...

  6. Surge flow irrigation under short field conditions in Egypt

    NARCIS (Netherlands)

    Ismail, S.M.; Depeweg, H.; Schultz, E.

    2004-01-01

    Several studies carried out in long furrows have shown that surge flow irrigation offers the potential of increasing the efficiency of irrigation. The effects of surge flow in short fields, such as in Egypt, are still not well known, however. To investigate the effect of surge flow irrigation in

  7. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Smeulers, J.P.M.; Gonzalez Díez, N.; Slot, H.J.

    2012-01-01

    Surge of turbo compressors can cause large almost step like changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. In spite of an anti-surge controller (ASC), at extreme events surge cycles may occur. In order to

  8. Numerical Evaluation of Storm Surge Indices for Public Advisory Purposes

    Science.gov (United States)

    Bass, B.; Bedient, P. B.; Dawson, C.; Proft, J.

    2016-12-01

    After the devastating hurricane season of 2005, shortcomings with the Saffir-Simpson Hurricane Scale's (SSHS) ability to characterize a tropical cyclones potential to generate storm surge became widely apparent. As a result, several alternative surge indices were proposed to replace the SSHS, including Powell and Reinhold's Integrated Kinetic Energy (IKE) factor, Kantha's Hurricane Surge Index (HSI), and Irish and Resio's Surge Scale (SS). Of the previous, the IKE factor is the only surge index to-date that truly captures a tropical cyclones integrated intensity, size, and wind field distribution. However, since the IKE factor was proposed in 2007, an accurate assessment of this surge index has not been performed. This study provides the first quantitative evaluation of the IKEs ability to serve as a predictor of a tropical cyclones potential surge impacts as compared to other alternative surge indices. Using the tightly coupled ADvanced CIRCulation and Simulating WAves Nearshore models, the surge and wave responses of Hurricane Ike (2008) and 78 synthetic tropical cyclones were evaluated against the SSHS, IKE, HSI and SS. Results along the upper TX coast of the Gulf of Mexico demonstrate that the HSI performs best in capturing the peak surge response of a tropical cyclone, while the IKE accounting for winds greater than tropical storm intensity (IKETS) provides the most accurate estimate of a tropical cyclones regional surge impacts. These results demonstrate that the appropriate selection of a surge index ultimately depends on what information is of interest to be conveyed to the public and/or scientific community.

  9. MP Joint Arthritis

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy MP Joint Arthritis Email to a friend * required ...

  10. Observations of Building Performance under Combined Wind and Surge Loading from Hurricane Harvey

    Science.gov (United States)

    Lombardo, F.; Roueche, D. B.; Krupar, R. J.; Smith, D. J.; Soto, M. G.

    2017-12-01

    Hurricane Harvey struck the Texas coastline on August 25, 2017, as a Category 4 hurricane - the first major hurricane to reach the US in twelve years. Wind gusts over 130 mph and storm surge as high as 12.5 ft caused widespread damage to buildings and critical infrastructure in coastal communities including Rockport, Fulton, Port Aransas and Aransas Pass. This study presents the methodology and preliminary observations of a coordinated response effort to document residential building performance under wind and storm surge loading. Over a twelve day survey period the study team assessed the performance of more than 1,000 individual, geo-located residential buildings. Assessments were logged via a smartphone application to facilitate rapid collection and collation of geotagged photographs, building attributes and structural details, and structural damage observations. Detailed assessments were also made of hazard intensity, specifically storm surge heights and both wind speed and direction indicators. Preliminary observations and findings will be presented, showing strong gradients in damage between inland and coastal regions of the affected areas that may be due in part to enhanced individual loading effects of wind and storm surge and potentially joint-hazard loading effects. Contributing factors to the many cases of disproportionate damage observed in close proximity will also be discussed. Ongoing efforts to relate building damage to near-surface hazard measurements (e.g., radar, anemometry) in close proximity will also be described.

  11. Nonlinear chaotic model for predicting storm surges

    Directory of Open Access Journals (Sweden)

    M. Siek

    2010-09-01

    Full Text Available This paper addresses the use of the methods of nonlinear dynamics and chaos theory for building a predictive chaotic model from time series. The chaotic model predictions are made by the adaptive local models based on the dynamical neighbors found in the reconstructed phase space of the observables. We implemented the univariate and multivariate chaotic models with direct and multi-steps prediction techniques and optimized these models using an exhaustive search method. The built models were tested for predicting storm surge dynamics for different stormy conditions in the North Sea, and are compared to neural network models. The results show that the chaotic models can generally provide reliable and accurate short-term storm surge predictions.

  12. Influence of Surge on Extreme Roll Amplitudes

    DEFF Research Database (Denmark)

    Vidic-Perunovic, Jelena; Rognebakke, Olav; Pedersen, Preben Terndrup

    2008-01-01

    Interference of the wave-induced ship surge motion with roll dynamics has been studied. The surge motion has been included in a previously derived hydrodynamic roll prediction model in order to account for the ship speed variation due to the longitudinal incident wave pressure force. Depending...... balanced in order to determine the added thrust term that would represent actions to maintain speed The resulting forward speed variation affects the frequency of encounter and the parametric roll resonant condition is directly influenced by this speed variation. The analysis procedure is demonstrated...... for an example containership sailing mainly in head sea condition and higher sea states. Sensitivity of the results to the added thrust model and vertical motion calculation is discussed....

  13. JOINT INVOLVEMENT IN SYPHILIS

    Directory of Open Access Journals (Sweden)

    T. I. Zlobina

    2016-01-01

    Full Text Available Joint involvement in syphilis has been considered as casuistry in recent years. At the same time, the high incidence of primary syphilis and the notified cases of late neurosyphilis may suggest that joint involvement in this disease is by no means always verified. Traditionally there are two forms of syphilitic arthritis: primary synovial (involving the articular membranes and sac and primary bone (involving the articular bones and cartilages ones. The paper describes the authors' clinical case of the primary bone form of articular syphilis in a 34-year-old man. 

  14. Application of bone scintigraphy

    International Nuclear Information System (INIS)

    Rondain, J.E.S.

    1996-01-01

    Bone scanning has varied applications, particularly in the file of oncology. It is used in the diagnosis and follow-up of patients with cancers that metastatize to the bones (breast, prostate CA), also in primary bone cancers, infections of the bones and joints. In early stages of primary breast CA (stage I and II), the incidence of unsuspected bone metastasis is only 1-5%. On the other hand, bone scans serve as a baseline study if bone mets occur at some later stage. In patients with stage II and III breast CA, the conversion from normal to abnormal bone scans is 15% and 17%, respectively, clearly in favor of a baseline bone scan. For prostate CA, bone scanning should be used in conjunction with PSA level determination. In advanced disease, a bone scan will define the extent of the metastases, show problematic lesions in weight-bearing bones, and even allow us to evaluate response to therapy in follow-up bone scans. In patients with lung CA, a positive bone scan will make surgery of the primary lesion inappropriate. For other cancers, a bone scan maybe used if there are other signs, whether clinical or chemical, indicating bone involvement. In patients with GIT, liver, skin, brain or bladder CA, routine bone scanning may be considered superfluous. For patients with suspected infection, a 3-phase bone scan is more desirable. In patients with septic arthritis, the bones of each side of the joint take up the radiopharmaceutical while in patients with cellulitis without bony involvement, only the first two phases (dynamic and bloodpool images) will be abnormal. Bone scanning is also used in avascular lesions such as Legg-calve-Perthes disease where one will see reduced uptake of Tc99m MDP. The advent of SPECT imaging has greatly increased the sensitivity in diagnosing AVN. (author)

  15. Joint imaging

    International Nuclear Information System (INIS)

    Hengst, W.

    1984-01-01

    Joint imaging is a proven diagnostic procedure which has become indispensable to the detection and treatment of different joint diseases in almost all disciplines. The method is suited for early diagnosis of joint affections both in soft tissue and bone which cannot be detected by X-ray or other procedures. The local activity accumulation depends on the rate of metabolism and is visualized in the scan, which in turn enables the extension and floridity of focal lesions to be evaluated and followed-up. Although joint scans may often give hints to probabilities relevant to differential diagnosis, the method is non-specific and only useful if based on the underlying clinical picture and X-ray finding, if possible. The radiation exposure is very low and does not represent a hazard in cases of adequate assessment of indication. In pregnant women and children the assessment of indication has to be based on very strict principles. The method is suited for out-patient diagnosis and can be applied in all installations equipped with a gamma camera and a technetium generator. (orig.) [de

  16. Coastal emergency managers' preferences for storm surge forecast communication.

    Science.gov (United States)

    Morrow, Betty Hearn; Lazo, Jeffrey K

    2014-01-01

    Storm surge, the most deadly hazard associated with tropical and extratropical cyclones, is the basis for most evacuation decisions by authorities. One factor believed to be associated with evacuation noncompliance is a lack of understanding of storm surge. To address this problem, federal agencies responsible for cyclone forecasts are seeking more effective ways of communicating storm surge threat. To inform this process, they are engaging various partners in the forecast and warning process.This project focuses on emergency managers. Fifty-three emergency managers (EMs) from the Gulf and lower Atlantic coasts were surveyed to elicit their experience with, sources of, and preferences for storm surge information. The emergency managers-who are well seasoned in hurricane response and generally rate the surge risk in their coastal areas above average or extremely high-listed storm surge as their major concern with respect to hurricanes. They reported a general lack of public awareness about surge. Overall they support new ways to convey the potential danger to the public, including the issuance of separate storm surge watches and warnings, and the expression of surge heights using feet above ground level. These EMs would like more maps, graphics, and visual materials for use in communicating with the public. An important concern is the timing of surge forecasts-whether they receive them early enough to be useful in their evacuation decisions.

  17. Characteristic Magnetic Resonance Imaging Findings in Rheumatoid Arthritis of the Temporomandibular Joint: Focus on Abnormal Bone Marrow Signal of the Mandibular Condyle, Pannus, and Lymph Node Swelling in the Parotid Glands.

    Science.gov (United States)

    Hirahara, Naohisa; Kaneda, Takashi; Muraoka, Hirotaka; Fukuda, Taiga; Ito, Kotaro; Kawashima, Yusuke

    2017-04-01

    The purpose of this study was to determine the characteristic magnetic resonance imaging (MRI) findings indicating bone and soft tissue involvement in patients with rheumatoid arthritis (RA) of the temporomandibular joints (TMJs). Twenty-one patients with RA and TMJ pain who underwent MRI examination of the TMJs at the authors' hospital from August 2006 to December 2014 were included in this study. Twenty-two patients with normal TMJs who underwent MRI examination at the authors' hospital from November to December 2014 were included as controls. MRI findings were compared between the 2 groups. MRI findings of RA in the TMJ included 1) abnormal disc position (95.2%), 2) abnormal disc morphology (83.3%), 3) joint effusion (30.9%), 4) osseous changes in the mandibular condyle (83.3%), 5) synovial proliferation (pannus; 85.7%), 6) erosion of the articular eminence and glenoid fossa (9.52%), 7) deformity of the articular eminence and glenoid fossa (16.6%), 8) abnormal bone marrow signal in the mandibular condyle (83.3%), and 9) swelling of lymph nodes in the parotid glands (78.5%). The abnormal bone marrow signal and pannus in the mandibular condyle and lymph node swelling in the parotid glands were markedly more common in patients with RA than in controls. MRI findings of RA of the TMJs were characterized by bone and soft tissue involvement, including abnormal bone marrow signal of the mandibular condyle, pannus, and swelling of lymph nodes in the parotid glands. These characteristic MRI findings could be useful in detecting RA in the TMJ in a clinical situation. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  18. Coastal Storm Surge Analysis: Storm Surge Results. Report 5: Intermediate Submission No. 3

    Science.gov (United States)

    2013-11-01

    Vickery, P., D. Wadhera, A. Cox, V. Cardone , J. Hanson, and B. Blanton. 2012. Coastal storm surge analysis: Storm forcing (Intermediate Submission No...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jeffrey L. Hanson, Michael F. Forte, Brian Blanton

  19. Compressor Surge Control Design Using Linear Matrix Inequality Approach

    OpenAIRE

    Uddin, Nur; Gravdahl, Jan Tommy

    2017-01-01

    A novel design for active compressor surge control system (ASCS) using linear matrix inequality (LMI) approach is presented and including a case study on piston-actuated active compressor surge control system (PAASCS). The non-linear system dynamics of the PAASCS is transformed into linear parameter varying (LPV) system dynamics. The system parameters are varying as a function of the compressor performance curve slope. A compressor surge stabilization problem is then formulated as a LMI probl...

  20. Flow in sodium loop surge tank

    International Nuclear Information System (INIS)

    Matal, O.; Martoch, J.

    1977-01-01

    The alternate liquid flow, the condition of vortex formation, gas entrainment in the discharge and the liquid level characteristics are studied using the models of the vertical and horizontal surge tanks of a sodium circuit with pump and heat exchangers. The conditions for vortex formation are more favourable in the vertical cylindrical tank than in the horizontal tank. The size of the vortex produced in the tank is affected by the initial speed circulation, due as a rule to an unsuitable inlet design. The proposed design considers an inlet below the sodium level using capped perforated pipes. Vortex formation, gas transport to the discharge pipe and turbulences of the liquid in the tank may be prevented by dividing the tank to the discharge and the inlet areas using perforated partitions, and by inserting the discharge cylinder above the discharge pipe outflow. The liquid level in the tank may be calmed by screens or by perforated plates. The adaptation of the surge tank of the sodium circuit will probably eliminate vortex formation and the entrainment of cover gas into the discharge piping and the sodium circuit under nominal conditions. (J.B.)

  1. The use of osteochondral allograft with bone marrow-derived mesenchymal cells and hinge joint distraction in the treatment of post-collapse stage of osteonecrosis of the femoral head.

    Science.gov (United States)

    Gagala, J; Tarczynska, M; Gaweda, K; Matuszewski, L

    2014-09-01

    Osteonecrosis of the femoral head is an entity which occurs mainly in young and active patients aged between 20 and 50. The success of hip joint preserving treatments ranges from 15% to 50% depending on the stage and amount of osteonecrotic lesion. Total hip replacement is indicated in late post-collapse hips but it has unsatisfactory survival because of the wear and osteolysis in young and active patients. Osteochondral allografts have been reported in the treatment of large articular lesions with defects in underlying bone in knee, talus and shoulder. By combining osteoconductive properties of osteochondral allograft with osteogenic abilities of bone marrow-derived mesenchymal cells it has a potential to be an alternative to an autologous graft. The adjunct of hinged joint distraction should minimize stresses in subchondral bone to promote creeping substitution and prevent femoral head collapse. Unlike current treatment modalities, it would provide both structural support and allow bony and articular substitution. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Significance of clinical evaluation of the metacarpophalangeal joint in relation to synovial/bone pathology in rheumatoid and psoriatic arthritis detected by magnetic resonance imaging.

    Science.gov (United States)

    Stone, Millicent A; White, Lawrence M; Gladman, Dafna D; Inman, Robert D; Chaya, Sam; Lax, Matthew; Salonen, David; Weber, Deborah A; Guthrie, Judy A; Pomeroy, Emma; Podbielski, Dominik; Keystone, Edward C

    2009-12-01

    Rheumatologists base many clinical decisions regarding the management of inflammatory joint diseases on joint counts performed at clinic. We investigated the reliability and accuracy of physically examining the metacarpophalangeal (MCP) joints to detect inflammatory synovitis using magnetic resonance imaging (MRI) as the gold standard. MCP joints 2 to 5 in both hands of 5 patients with rheumatoid arthritis (RA) and 5 with psoriatic arthritis (PsA) were assessed by 5 independent examiners for joint-line swelling (visually and by palpation); joint-line tenderness by palpation (tender joint count, TJC) and stress pain; and by MRI (1.5 Tesla superconducting magnet). Interrater reliability was assessed using kappa statistics, and agreement between examination and corresponding MRI assessment was assessed by Fisher's exact tests (p 0.8) and positive predictive value (= 0.8). For PsA, significant associations exist between TJC and MRI synovitis scores (p < 0.01) and stress pain and MRI edema scores (p < 0.04). Assessment of swelling by palpation was not significantly associated with synovitis or edema as determined by MRI in RA or PsA (p = 0.54-1.0). In inflammatory arthritis, disease activity in MCP joints can be reliably assessed at the bedside by examining for joint-line tenderness (TJC) and visual inspection for swelling. Clinical assessment may have to be complemented by other methods for evaluating disease activity in the joint, such as MRI, particularly in patients with PsA.

  3. Surrogate modeling of joint flood risk across coastal watersheds

    Science.gov (United States)

    Bass, Benjamin; Bedient, Philip

    2018-03-01

    This study discusses the development and performance of a rapid prediction system capable of representing the joint rainfall-runoff and storm surge flood response of tropical cyclones (TCs) for probabilistic risk analysis. Due to the computational demand required for accurately representing storm surge with the high-fidelity ADvanced CIRCulation (ADCIRC) hydrodynamic model and its coupling with additional numerical models to represent rainfall-runoff, a surrogate or statistical model was trained to represent the relationship between hurricane wind- and pressure-field characteristics and their peak joint flood response typically determined from physics based numerical models. This builds upon past studies that have only evaluated surrogate models for predicting peak surge, and provides the first system capable of probabilistically representing joint flood levels from TCs. The utility of this joint flood prediction system is then demonstrated by improving upon probabilistic TC flood risk products, which currently account for storm surge but do not take into account TC associated rainfall-runoff. Results demonstrate the source apportionment of rainfall-runoff versus storm surge and highlight that slight increases in flood risk levels may occur due to the interaction between rainfall-runoff and storm surge as compared to the Federal Emergency Management Association's (FEMAs) current practices.

  4. Imaging of low-grade bone infection with a technetium-99m labelled monoclonal anti-NCA-90 Fab' fragment in patients with previous joint surgery

    Energy Technology Data Exchange (ETDEWEB)

    Ivaneeviae, V.; Sandrock, D.; Munz, D.L. [Clinic for Nuclear Medicine, University Hospital Charite, Humboldt University of Berlin (Germany); Perka, C.; Hasart, O. [Orthopaedic Clinic, University Hospital Charite, Humboldt University of Berlin (Germany)

    2002-04-01

    or 7, infection was verified and scintigraphic outcome was accordingly true positive, while the remaining patient was true negative. In conclusion, MN3 Fab' scintigraphy proved to be highly sensitive but not specific in diagnosing low-grade infections of the hip and knee regions in patients with previous joint surgery. The method seems reliable in excluding but not in proving the presence of infection. MN3 Fab' scintigraphy should not be applied in patients with Girdlestone situations. Assessment of infection using the Zimmerli score was more reliable than MN3 Fab' scintigraphy in this group of patients without rheumatoid arthritis as the underlying disease. Considering results from the literature concerning leucocyte scintigraphy, MN3 Fab' scintigraphy may be clinically useful in evaluating low-grade bone infection in THA and TKA patients with Zimmerli scores above 5 and concomitant rheumatoid arthritis or other inflammatory diseases. (orig.)

  5. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... views of bone, they provide little information about muscles, tendons or joints. An MRI may be more useful in identifying bone and joint injuries (e.g., meniscal and ligament tears in the knee, rotator cuff and labrum tears ...

  6. TU-C-12A-12: Differentiating Bone Lesions and Degenerative Joint Disease in NaF PET/CT Scans Using Machine Learning

    Energy Technology Data Exchange (ETDEWEB)

    Perk, T; Bradshaw, T; Muzahir, S; Jeraj, R [University of Wisconsin, Madison, Wisconsin (United States); Meyer, E [Case Western Reserve University School of Medicine, Cleveland, Ohio (United States)

    2014-06-15

    Purpose: [F-18]NaF PET can be used to image bone metastases; however, tracer uptake in degenerative joint disease (DJD) often appears similar to metastases. This study aims to develop and compare different machine learning algorithms to automatically identify regions of [F-18]NaF scans that correspond to DJD. Methods: 10 metastatic prostate cancer patients received whole body [F-18]NaF PET/CT scans prior to treatment. Image segmentation resulted in 852 ROIs, 69 of which were identified by a nuclear medicine physician as DJD. For all ROIs, various PET and CT textural features were computed. ROIs were divided into training and testing sets used to train eight different machine learning classifiers. Classifiers were evaluated based on receiver operating characteristics area under the curve (AUC), sensitivity, specificity, and positive predictive value (PPV). We also assessed the added value of including CT features in addition to PET features for training classifiers. Results: The training set consisted of 37 DJD ROIs with 475 non-DJD ROIs, and the testing set consisted of 32 DJD ROIs with 308 non-DJD ROIs. Of all classifiers, generalized linear models (GLM), decision forests (DF), and support vector machines (SVM) had the best performance. AUCs of GLM (0.929), DF (0.921), and SVM (0.889) were significantly higher than the other models (p<0.001). GLM and DF, overall, had the best sensitivity, specificity, and PPV, and gave a significantly better performance (p<0.01) than all other models. PET/CT GLM classifiers had higher AUC than just PET or just CT. GLMs built using PET/CT information had superior or comparable sensitivities, specificities and PPVs to just PET or just CT. Conclusion: Machine learning algorithms trained with PET/CT features were able to identify some cases of DJD. GLM outperformed the other classification algorithms. Using PET and CT information together was shown to be superior to using PET or CT features alone. Research supported by the Prostate

  7. TU-C-12A-12: Differentiating Bone Lesions and Degenerative Joint Disease in NaF PET/CT Scans Using Machine Learning

    International Nuclear Information System (INIS)

    Perk, T; Bradshaw, T; Muzahir, S; Jeraj, R; Meyer, E

    2014-01-01

    Purpose: [F-18]NaF PET can be used to image bone metastases; however, tracer uptake in degenerative joint disease (DJD) often appears similar to metastases. This study aims to develop and compare different machine learning algorithms to automatically identify regions of [F-18]NaF scans that correspond to DJD. Methods: 10 metastatic prostate cancer patients received whole body [F-18]NaF PET/CT scans prior to treatment. Image segmentation resulted in 852 ROIs, 69 of which were identified by a nuclear medicine physician as DJD. For all ROIs, various PET and CT textural features were computed. ROIs were divided into training and testing sets used to train eight different machine learning classifiers. Classifiers were evaluated based on receiver operating characteristics area under the curve (AUC), sensitivity, specificity, and positive predictive value (PPV). We also assessed the added value of including CT features in addition to PET features for training classifiers. Results: The training set consisted of 37 DJD ROIs with 475 non-DJD ROIs, and the testing set consisted of 32 DJD ROIs with 308 non-DJD ROIs. Of all classifiers, generalized linear models (GLM), decision forests (DF), and support vector machines (SVM) had the best performance. AUCs of GLM (0.929), DF (0.921), and SVM (0.889) were significantly higher than the other models (p<0.001). GLM and DF, overall, had the best sensitivity, specificity, and PPV, and gave a significantly better performance (p<0.01) than all other models. PET/CT GLM classifiers had higher AUC than just PET or just CT. GLMs built using PET/CT information had superior or comparable sensitivities, specificities and PPVs to just PET or just CT. Conclusion: Machine learning algorithms trained with PET/CT features were able to identify some cases of DJD. GLM outperformed the other classification algorithms. Using PET and CT information together was shown to be superior to using PET or CT features alone. Research supported by the Prostate

  8. A case study of an axillary artery pseudoaneurysm following anterior dislocation of the glenohumeral joint: A rare presentation on plain film radiographs

    International Nuclear Information System (INIS)

    Whittam, Katie; Hardy, Maryann

    2007-01-01

    Axillary pseudoaneurysm is a rare but important complication of anterior glenohumeral joint dislocation. Diagnosis of axillary pseudoaneurysm is predominantly undertaken following clinical examination but where diagnosis is uncertain, Doppler ultrasound is the imaging examination of choice to confirm diagnosis. In this case study, the initial clinical signs of axillary pseudoaneurysm were masked by the presenting trauma and, although findings indicative of pseudoaneurysm were present on late plain film images, they were not immediately recognised. Misdiagnosis or delayed diagnosis of axillary pseudoaneurysm may result in upper limb morbidity or patient mortality. Consequently, the prompt and accurate identification of an axillary pseudoaneurysm on plain film radiographs, although rare, is essential. Yet for inexperienced film readers, correctly identifying an axillary pseudoaneurysm can be difficult due to its apparent similarity to other pathologies. This article will highlight the differences in radiological appearances between a pseudoaneurysm and a gleno-humeral joint effusion to raise radiographer awareness of the risks and clinical signs of an axillary pseudoaneurysm post gleno-humeral joint dislocation and discuss the difficulties encountered in its diagnosis. Finally, this review will evaluate current diagnostic practices in comparison with best practice, as identified in the literature [Fitzgerald JF, Keates J. False aneurysm as a late complication of anterior shoulder dislocation. Ann Surg 1975;6:785-6; Drury JK, Scullion JE. Vascular complications of anterior dislocation of the shoulder. Br J Surg 1980;67(8):579-81. Waxman DL, France MP, Douglas T, Harryman I. Late lateral displacement of the humeral head after closed reduction of dislocation: a sign of vascular injury. J Bone Joint Surg 1996;78(6):907-10

  9. Tide-surge interaction in the English Channel

    Directory of Open Access Journals (Sweden)

    D. Idier

    2012-12-01

    Full Text Available The English Channel is characterised by strong tidal currents and a wide tidal range, such that their influence on surges is expected to be non-negligible. In order to better assess storm surges in this zone, tide-surge interactions are investigated. A preliminary data analysis on hourly surges indicates some preferential times of occurrence of large storm surges at rising tide, especially in Dunkerque. To examine this further, a numerical modelling approach is chosen, based on the 2DH shallow-water model (MARS. The surges are computed both with and without tide interaction. For the two selected events (the November 2007 North Sea and March 2008 Atlantic storms, it appears that the instantaneous tide-surge interaction is seen to be non-negligible in the eastern half of the English Channel, reaching values of 74 cm (i.e. 50% of the same event maximal storm surge in the Dover Strait for the studied cases. This interaction decreases in westerly direction. In the risk-analysis community in France, extreme water levels have been determined assuming skew surges and tide as independent. The same hydrodynamic model is used to investigate this dependence in the English Channel. Simple computations are performed with the same meteorological forcing, while varying the tidal amplitude, and the skew surge differences DSS are analysed. Skew surges appear to be tide-dependent, with negligible values of DSS (<0.05 m over a large portion of the English Channel, although reaching several tens of centimetres in some locations (e.g. the Isle of Wight and Dover Strait.

  10. Imaging findings of charcot joint

    International Nuclear Information System (INIS)

    Meng Quanfei; Zhou Chunxiang; Chen Yingming; Jiang Bo

    2003-01-01

    Objective: To analyze the MRI characters of Charcot joint, and to evaluate the diagnostic value of X-ray, CT, and MRI on Charcot joint. Methods: Eight patients with 8 Charcot joints underwent X-ray, CT, and MR examinations. 6 of them had syringomyelia, 1 patient had injury of the spinal cord, and 1 case had diabetes. All 8 patients had sensory reduction or deficit in the sick extremities. Results: There were two types of Charcot joint, hypertrophic and atrophic. Radiographic and CT features of hypertrophic joint (n=3) showed hyperostotic osteosclerosis and mammoth osteophytes in the sick bones, periarticular ossification, and articular disorganization. Radiographic and CT features of atrophic joint (n=5) showed extensive bone resorption (destruction), periarticular debris, and articular disorganization. Main MRI features of Charcot joint included hydrarthrosis within joint capsule, thickened, loose, and elongated joint capsule with para-joint, peri-diaphysis, and inter-muscular extension in a pseudopodia pattern. The irregular joint capsule wall was presented as mild hypointensity on T 1 WI, slight hyper-intensity on T 2 WI, and was markedly enhanced after Gd-DTPA was administrated, which was considered as a characteristic manifestation of the lesion. Soft tissue mass containing hypo-intense stripes on both T 1 WI and T 2 WI was commonly noted adjacent to the involved joint. Conclusion: X-rays plain film is the first choice for the diagnosis of Charcot joint, and MRI is pretty useful in the diagnosis of Charcot joint

  11. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor; Bone tumor - benign ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  12. Comparison of new bone formation, implant integration, and biocompatibility between RGD-hydroxyapatite and pure hydroxyapatite coating for cementless joint prostheses--an experimental study in rabbits.

    Science.gov (United States)

    Bitschnau, Achim; Alt, Volker; Böhner, Felicitas; Heerich, Katharina Elisabeth; Margesin, Erika; Hartmann, Sonja; Sewing, Andreas; Meyer, Christof; Wenisch, Sabine; Schnettler, Reinhard

    2009-01-01

    This is the first work to report on additional Arginin-Glycin-Aspartat (RGD) coating on precoated hydroxyapatite (HA) surfaces regarding new bone formation, implant bone contact, and biocompatibility compared to pure HA coating and uncoated stainless K-wires. There were 39 rabbits in total with 6 animals for the RGD-HA and HA group for the 4 week time period and 9 animals for each of the 3 implant groups for the 12 week observation. A 2.0 K-wire either with RGD-HA or with pure HA coating or uncoated was placed into the intramedullary canal of the tibia. After 4 and 12 weeks, the tibiae were harvested and three different areas of the tibia were assessed for quantitative and qualitative histology for new bone formation, direct implant bone contact, and formation of multinucleated giant cells. Both RGD-HA and pure HA coating showed statistically higher new bone formation and implant bone contact after 12 weeks than the uncoated K-wire. There were no significant differences between the RGD-HA and the pure HA coating in new bone formation and direct implant bone contact after 4 and 12 weeks. The number of multinucleated giant did not differ significantly between the RGD-HA and HA group after both time points. Overall, no significant effects of an additional RGD coating on HA surfaces were detected in this model after 12 weeks. (c) 2008 Wiley Periodicals, Inc.

  13. Will oscillating wave surge converters survive tsunamis?

    Directory of Open Access Journals (Sweden)

    L. O’Brien

    2015-07-01

    Full Text Available With an increasing emphasis on renewable energy resources, wave power technology is becoming one of the realistic solutions. However, the 2011 tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed, creating large destructive waves. The question posed here is whether an oscillating wave surge converter (OWSC could withstand the force of an incoming tsunami. Several tools are used to provide an answer: an analytical 3D model developed within the framework of linear theory, a numerical model based on the non-linear shallow water equations and empirical formulas. Numerical results show that run-up and draw-down can be amplified under some circumstances, leading to an OWSC lying on dry ground!

  14. Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

    DEFF Research Database (Denmark)

    Atkinson, Sara Marie; Bleil, Janine; Maier, Rene

    2016-01-01

    . Periarticular bone formation was observed from day 10. Induction of new bone formation indicated by enhanced Runx2, collagen X, osteocalcin, MMP2, MMP9, and MMP13 mRNA expression was observed only between days 8 and 11. Anti-RANKL treatment resulted in a modest reduction in paw and ankle swelling...... and bone formation were analyzed by mRNA deep sequencing. Serum concentrations of tartrate-resistant acid phosphatase 5b, carboxy-terminal telopeptide I (CTX-I), matrix metalloproteinase 3 (MMP3), and serum amyloid P component (SAP) were determined by enzyme-linked immunosorbent assay. Anti......-RANKL monoclonal antibody treatment was initiated at the time of immunization. Results: Bone destruction (MMP3 serum levels, cathepsin B activity, and RANKL mRNA) peaked at day 3 after arthritis induction, followed by a peak in cartilage destruction and bone erosion on day 5 after arthritis induction...

  15. Overview and Design Considerations of Storm Surge Barriers

    NARCIS (Netherlands)

    Mooyaart, L.F.; Jonkman, S.N.

    2017-01-01

    The risk of flooding in coastal zones is expected to increase due to sea level rise and economic development. In larger bays, estuaries, and coastal waterways, storm surge barriers can be constructed to temporarily close off these systems during storm surges to provide coastal flood protection.

  16. Using satellite altimetry and tide gauges for storm surge warning

    DEFF Research Database (Denmark)

    Andersen, O. B.; Cheng, Yongcun; Deng, X.

    2014-01-01

    of Australia. For both locations we have tried to investigate the possibilities and limitations of the use of satellite altimetry to capture high frequency signals (surges) using data from the past 20 years. The two regions are chosen to represent extra-tropical and tropical storm surge conditions. We have...

  17. Study of storm surge trends in typhoon-prone coastal areas based on observations and surge-wave coupled simulations

    Science.gov (United States)

    Feng, Xingru; Li, Mingjie; Yin, Baoshu; Yang, Dezhou; Yang, Hongwei

    2018-06-01

    This is a study of the storm surge trends in some of the typhoon-prone coastal areas of China. An unstructured-grid, storm surge-wave-tide coupled model was established for the coastal areas of Zhejiang, Fujian and Guangdong provinces. The coupled model has a high resolution in coastal areas, and the simulated results compared well with the in situ observations and satellite altimeter data. The typhoon-induced storm surges along the coast of the study areas were simulated based on the established coupled model for the past 20 years (1997-2016). The simulated results were used to analyze the trends of the storm surges in the study area. The extreme storm surge trends along the central coast of Fujian Province reached up to 0.06 m/y, significant at the 90% confidence level. The duration of the storm surges greater than 1.0 and 0.7 m had an increasing trend along the coastal area of northern Fujian Province, significant at confidence levels of 70%-91%. The simulated trends of the extreme storm surges were also validated by observations from two tide gauge stations. Further studies show that the correlation coefficient (RTE) between the duration of the storm surge greater than 1 m and the annual ENSO index can reach as high as 0.62, significant at the 99% confidence level. This occurred in a location where the storm surge trend was not significant. For the areas with significant increasing storm surge trends, RTE was small and not significant. This study identified the storm surge trends for the full complex coastline of the study area. These results are useful both for coastal management by the government and for coastal engineering design.

  18. Prosthetic Joint Infections

    Science.gov (United States)

    Aslam, Saima; Darouiche, Rabih O.

    2012-01-01

    Prosthetic joint infections represent a major therapeutic challenge for both healthcare providers and patients. This paper reviews the predisposing factors, pathogenesis, microbiology, diagnosis, treatment and prophylaxis of prosthetic joint infection. The most optimal management strategy should be identified based on a number of considerations including type and duration of infection, antimicrobial susceptibility of the infecting pathogen, condition of infected tissues and bone stock, patient wishes and functional status. PMID:22847032

  19. Harmful effects of lightning surge discharge on communications terminal equipments

    International Nuclear Information System (INIS)

    Liang, Sisi; Xu, Xiaoying; Tao, Zhigang; Dai, Yanling

    2013-01-01

    The interference problem of lightning surges on electronic and telecommunication products were examined, and a series of experiments were conducted to analyze the failure situations to find out the mechanisms of failures caused by the lightning surge. In addition, the ways in which lightning surges damaged equipment were deduced. It was found that failure positions were scattered and appeared in groups, and most of them were ground discharge. Internet access transformer had high withstand-voltage under the lightning pulse, and the lightning surge seldom passed through the internet access transformer. The lightning current can release to the ground via the computer network adapter of the terminal user. The study will help to improve the performance of lightning surge protection circuit and protection level.

  20. Tropical Cyclone Storm Surge Inundation and Velocity Hazard Mapping of the State of Andhra Pradesh (India) using ADCIRC

    Science.gov (United States)

    Brackins, J. T.; Kalyanapu, A. J.

    2017-12-01

    The Northern Indian Ocean Bay of Bengal region, including parts of India, Bangladesh, Myanmar, and Sri Lanka, is the largest bay in the world and is structured in such a manner as to produce the world's largest tropical cyclone (TC) storm surges (SS), with approximately five surge events greater than 5 meters in magnitude each decade. (Needham et al. 2015). Although some studies have been performed to attempt to capture the magnitude and location of historical surges (Shaji et al. 2014) and to model surges in the immediate sense, there is a notable lack of application to the effects on coastal infrastructure in these areas. Given that these areas are some of the most densely populated and least economically able to prepare and recover, it is important to consider the potential effects of storm surge to discover areas where improvements can be made with the limited resources available to these areas. To this end, an ADvanced-CIRCulation (ADCIRC) model (Luettich and Westerink 2004) was created for the Bay of Bengal, using the General Bathymetric Chart of the Oceans (GEBCO 2014) as bathymetric and topographic data, and a combination of the Joint Typhoon Warning Center (JTWC) and India Meteorological Department (IMD) records for storm tracks. For the state of Andhra Pradesh, several major TC events ranging from 1977 to 2014 were selected to be modeled with the goal of creating hazard maps of storm surge inundation and velocity for the state. These hazard maps would be used to identify high-vulnerability areas with the goal of implementing land-use planning and coastal development practices that will aid in ameliorating both the loss of life and economic damages sustained as a result of these TCs.

  1. Roentgenologic study of sesamoid bones

    International Nuclear Information System (INIS)

    Lee, Son Young; Park, Byung Hwan; Kim, Dong Hyuk

    1980-01-01

    A radiological study on sesamoid bones of hands and feet was done in Korea adults who visited the Capital Armed Forces General Hospital Of Korea during last 10 months from Jan. 1, to Oct, 30, 1970. The incidence of presence or absence of sesamoid bones in each possible site and shape and partition were studied in 250 males and 200 females. The results are follow: 1. In hands, two sesamoids are present at metacarpophalangel joint of thumb in all and one at metacarpophalangeal joint of little finger in half, metacarpophalangeal joint of index, interphalangeal joint of thumb. Metacarpophalangeal joint of ring finger were other sites, in order of frequency. 2. In feet, two sesamoid are present at metacarpophalangeal joint of great toe in all, but the incidence at other sites are much lower comparison to hands and the sites are interphalangeal joint of great toe, metacarpophalangeal joint of 5th toe, metacarpophalangeal joint of 2nd toe, and metacarpophalangeal joint of 4th toe in order frequency. 3. In comparison with sexes, the incidence is a little greater in female at every site. 4. In general, the partition line of sesamoid bone is transverse, and fracture line of sesamoid is longitudinal. 5. In comparison with Europeans, the incidence of sesamoid bone at interphalangeal joint of thumb and great toe is about half, and at other sites, except metacaso phalangeal joint of thumb abd great toe, the incidence was smaller in each site.

  2. Storm Surge and Tide Interaction: A Complete Paradigm

    Science.gov (United States)

    Horsburgh, K.

    2014-12-01

    Estimates show that in 2005, in the largest 136 coastal cities, there were 40 million people and 3,000 billion of assets exposed to 1 in 100 year coastal flood events. Mean sea level rise will increase this exposure to 150 million people and 35,000 billion of assets by 2070. Any further change in the statistics of flood frequency or severity would impact severely on economic and social systems. It is therefore crucial to understand the physical drivers of extreme storm surges, and to have confidence in datasets used for extreme sea level statistics. Much previous research has focussed on the process of tide-surge interaction, and it is now widely accepted that the physical basis of tide-surge interaction is that a phase shift of the tidal signal represents the effect of the surge on the tide. The second aspect of interaction is that shallow water momentum considerations imply that differing tidal states should modulate surge generation: wind stress should have greater surge-generating potential on lower tides. We present results from a storm surge model of the European shelf that demonstrate that tidal range does have an effect on the surges generated. The cycle-integrated effects of wind stress (i.e. the skew surge) are greater when tidal range is low. Our results contradict the absence of any such correlation in tide gauge records. This suggests that whilst the modulating effect of the tide on the skew surge (the time-independent difference between peak prediction and observations) is significant, the difference between individual storms is dominant. This implies that forecasting systems must predict salient detail of the most intense storms. A further implication is that flood forecasting models need to simulate tides with acceptable accuracy at all coastal locations. We extend our model analysis to show that the same modulation of storm surges (by tidal conditions) applies to tropical cyclones. We conduct simulations using a mature operational storm surge model

  3. In vitro biomechanical comparison of three different types of single- and double-row arthroscopic rotator cuff repairs: analysis of continuous bone-tendon contact pressure and surface during different simulated joint positions.

    Science.gov (United States)

    Grimberg, Jean; Diop, Amadou; Kalra, Kunal; Charousset, Christophe; Duranthon, Louis-Denis; Maurel, Nathalie

    2010-03-01

    We assessed bone-tendon contact surface and pressure with a continuous and reversible measurement system comparing 3 different double- and single-row techniques of cuff repair with simulation of different joint positions. We reproduced a medium supraspinatus tear in 24 human cadaveric shoulders. For the 12 right shoulders, single-row suture (SRS) and then double-row bridge suture (DRBS) were used. For the 12 left shoulders, DRBS and then double-row cross suture (DRCS) were used. Measurements were performed before, during, and after knot tying and then with different joint positions. There was a significant increase in contact surface with the DRBS technique compared with the SRS technique and with the DRCS technique compared with the SRS or DRBS technique. There was a significant increase in contact pressure with the DRBS technique and DRCS technique compared with the SRS technique but no difference between the DRBS technique and DRCS technique. The DRCS technique seems to be superior to the DRBS and SRS techniques in terms of bone-tendon contact surface and pressure. Copyright 2010 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  4. Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a meta-analysis of randomized controlled trials

    Directory of Open Access Journals (Sweden)

    Kelley George A

    2012-09-01

    Full Text Available Abstract Background Low bone mineral density (BMD and subsequent fractures are a major public health problem in postmenopausal women. The purpose of this study was to use the aggregate data meta-analytic approach to examine the effects of ground (for example, walking and/or joint reaction (for example, strength training exercise on femoral neck (FN and lumbar spine (LS BMD in postmenopausal women. Methods The a priori inclusion criteria were: (1 randomized controlled trials, (2 exercise intervention ≥ 24 weeks, (3 comparative control group, (4 postmenopausal women, (5 participants not regularly active, i.e., less than 150 minutes of moderate intensity (3.0 to 5.9 metabolic equivalents weight bearing endurance activity per week, less than 75 minutes of vigorous intensity (> 6.0 metabolic equivalents weight bearing endurance activity per week, resistance training g was calculated for each FN and LS BMD result and pooled using random-effects models. Z-score alpha values, 95%confidence intervals (CI and number-needed-to-treat (NNT were calculated for pooled results. Heterogeneity was examined using Q and I2. Mixed-effects ANOVA and simple meta-regression were used to examine changes in FN and LS BMD according to selected categorical and continuous variables. Statistical significance was set at an alpha value ≤0.05 and a trend at >0.05 to ≤ 0.10. Results Small, statistically significant exercise minus control group improvements were found for both FN (28 g’s, 1632 participants, g = 0.288, 95% CI = 0.102, 0.474, p = 0.002, Q = 90.5, p I2 = 70.1%, NNT = 6 and LS (28 g’s, 1504 participants, g = 0.179, 95% CI = −0.003, 0.361, p = 0.05, Q = 77.7, p I2 = 65.3%, NNT = 6 BMD. Clinically, it was estimated that the overall changes in FN and LS would reduce the 20-year relative risk of osteoporotic fracture at any site by approximately 11% and 10%, respectively. None of the mixed

  5. Identifying compositional and structural changes in spongy and subchondral bone from the hip joints of patients with osteoarthritis using Raman spectroscopy

    Science.gov (United States)

    Buchwald, Tomasz; Niciejewski, Krzysztof; Kozielski, Marek; Szybowicz, Mirosław; Siatkowski, Marcin; Krauss, Hanna

    2012-01-01

    Raman microspectroscopy was used to examine the biochemical composition and molecular structure of extracellular matrix in spongy and subchondral bone collected from patients with clinical and radiological evidence of idiopathic osteoarthritis of the hip and from patients who underwent a femoral neck fracture, as a result of trauma, without previous clinical and radiological evidence of osteoarthritis. The objectives of the study were to determine the levels of mineralization, carbonate accumulation and collagen quality in bone tissue. The subchondral bone from osteoarthritis patients in comparison with control subject is less mineralized due to a decrease in the hydroxyapatite concentration. However, the extent of carbonate accumulation in the apatite crystal lattice increases, most likely due to deficient mineralization. The alpha helix to random coil band area ratio reveals that collagen matrix in subchondral bone is more ordered in osteoarthritis disease. The hydroxyapatite to collagen, carbonate apatite to hydroxyapatite and alpha helix to random coil band area ratios are not significantly changed in the differently loaded sites of femoral head. The significant differences also are not visible in mineral and organic constituents' content in spongy bone beneath the subchondral bone in osteoarthritis disease.

  6. Neurosteroids, trigger of the LH surge

    Science.gov (United States)

    Kuo, John; Micevych, Paul

    2012-01-01

    Recent experiments from our laboratory are consistent with the idea that hypothalamic astrocytes are critical components of the central nervous system (CNS) mediated estrogen positive feedback mechanism. The “astrocrine hypothesis” maintains that ovarian estradiol rapidly increases free cytoplasmic calcium concentrations ([Ca2+]i) that facilitate progesterone synthesis in astrocytes. This hypothalamic neuroprogesterone along with the elevated estrogen from the ovaries allows for the surge release of gonadotropin-releasing hormone (GnRH) that triggers the pituitary luteinizing hormone (LH) surge. A narrow range of estradiol stimulated progesterone production supports an “off-on-off” mechanism regulating the transition from estrogen negative feedback to estrogen positive feedback, and back again. The rapidity of the [Ca2+]i response and progesterone synthesis support a non-genomic, membrane-initiated signaling mechanism. In hypothalamic astrocytes, membrane-associated estrogen receptors (mERs) signal through transactivation of the metabotropic glutamate receptor type 1a (mGluR1a), implying that astrocytic function is influenced by surrounding glutamatergic nerve terminals. Although other putative mERs, such as mERβ, STX-activated mER-Gαq, and G protein-coupled receptor 30 (GPR30), are present and participate in membrane-mediated signaling, their influence in reproduction is still obscure since female reproduction be it estrogen positive feedback or lordosis behavior requires mERα. The astrocrine hypothesis is also consistent with the well-known sexual dimorphism of estrogen positive feedback. In rodents, only post-pubertal females exhibit this positive feedback. Hypothalamic astrocytes cultured from females, but not males, responded to estradiol by increasing progesterone synthesis. Estrogen autoregulates its own signaling by regulating levels of mERα in the plasma membrane of female astrocytes. In male astrocytes, the estradiol-induced increase in m

  7. Surge dynamics on Bering Glacier, Alaska, in 2008–2011

    Directory of Open Access Journals (Sweden)

    M. Braun

    2012-11-01

    Full Text Available A surge cycle of the Bering Glacier system, Alaska, is examined using observations of surface velocity obtained using synthetic aperture radar (SAR offset tracking, and elevation data obtained from the University of Alaska Fairbanks LiDAR altimetry program. After 13 yr of quiescence, the Bering Glacier system began to surge in May 2008 and had two stages of accelerated flow. During the first stage, flow accelerated progressively for at least 10 months and reached peak observed velocities of ~ 7 m d−1. The second stage likely began in 2010. By 2011 velocities exceeded 9 m d−1 or ~ 18 times quiescent velocities. Fast flow continued into July 2011. Surface morphology indicated slowing by fall 2011; however, it is not entirely clear if the surge is yet over. The quiescent phase was characterized by small-scale acceleration events that increased driving stresses up to 70%. When the surge initiated, synchronous acceleration occurred throughout much of the glacier length. Results suggest that downstream propagation of the surge is closely linked to the evolution of the driving stress during the surge, because driving stress appears to be tied to the amount of resistive stress provided by the bed. In contrast, upstream acceleration and upstream surge propagation is not dependent on driving stress evolution.

  8. Present dynamics and future prognosis of a slowly surging glacier

    Directory of Open Access Journals (Sweden)

    G. E. Flowers

    2011-03-01

    Full Text Available Glacier surges are a well-known example of an internal dynamic oscillation whose occurrence is not a direct response to the external climate forcing, but whose character (i.e. period, amplitude, mechanism may depend on the glacier's environmental or climate setting. We examine the dynamics of a small (∼5 km2 valley glacier in Yukon, Canada, where two previous surges have been photographically documented and an unusually slow surge is currently underway. To characterize the dynamics of the present surge, and to speculate on the future of this glacier, we employ a higher-order flowband model of ice dynamics with a regularized Coulomb-friction sliding law in both diagnostic and prognostic simulations. Diagnostic (force balance calculations capture the measured ice-surface velocity profile only when non-zero basal water pressures are prescribed over the central region of the glacier, coincident with where evidence of the surge has been identified. This leads to sliding accounting for 50–100% of the total surface motion in this region. Prognostic simulations, where the glacier geometry evolves in response to a prescribed surface mass balance, reveal a significant role played by a bedrock ridge beneath the current equilibrium line of the glacier. Ice thickening occurs above the ridge in our simulations, until the net mass balance reaches sufficiently negative values. We suggest that the bedrock ridge may contribute to the propensity for surges in this glacier by promoting the development of the reservoir area during quiescence, and may permit surges to occur under more negative balance conditions than would otherwise be possible. Collectively, these results corroborate our interpretation of the current glacier flow regime as indicative of a slow surge that has been ongoing for some time, and support a relationship between surge incidence or character and the net mass balance. Our results also highlight the importance of glacier bed

  9. Bone scintiscanning updated.

    Science.gov (United States)

    Lentle, B C; Russell, A S; Percy, J S; Scott, J R; Jackson, F I

    1976-03-01

    Use of modern materials and methods has given bone scintiscanning a larger role in clinical medicine, The safety and ready availability of newer agents have led to its greater use in investigating both benign and malignant disease of bone and joint. Present evidence suggests that abnormal accumulation of 99mTc-polyphosphate and its analogues results from ionic deposition at crystal surfaces in immature bone, this process being facilitated by an increase in bone vascularity. There is, also, a component of matrix localization. These factors are in keeping with the concept that abnormal scintiscan sites represent areas of increased osteoblastic activity, although this may be an oversimplification. Increasing evidence shows that the bone scintiscan is more sensitive than conventional radiography in detecting focal disease of bone, and its ability to reflect the immediate status of bone further complements radiographic findings. The main limitation of this method relates to nonspecificity of the results obtained.

  10. China's electric car surge

    International Nuclear Information System (INIS)

    Wang, Yunshi; Sperling, Daniel; Tal, Gil; Fang, Haifeng

    2017-01-01

    China's plug-in electric vehicle (PEV) sales, comprising both battery electric and plug-in hybrid vehicles, surged 343% in 2015, and are expected to reach 2 million by 2020. Two factors are crucial to this sudden transformation: 1) massive central and local government subsidies, and 2) huge non-monetary incentives via exemptions from restrictions on vehicle ownership in Beijing, Shanghai, and elsewhere. Innovative business models and greatly expanded vehicle offerings, especially by local Chinese manufacturers, also helped accelerate PEV sales and infrastructure deployment. However, continued sales growth is threatened by persistent regional protectionism, the unsustainability of these large subsidies, and widely reported cheating by some automakers. We suggest some innovative policies that China might pioneer and transfer elsewhere. - Highlights: • The rapid growth was a result of massive central and local government subsidies. • Exemptions from restrictions on vehicle ownership play even more important role. • A comparative case study of Beijing and Shanghai. • Persistent regional protectionism impedes the development of China's PEV industry. • Focusing on the use of PEVs is a better way to achieve eVMT.

  11. Osteoblastoma crossing the sacro-iliac joint

    Energy Technology Data Exchange (ETDEWEB)

    Whittingham-Jones, Paul; Lehovsky, Jan [Royal National Orthopaedic Hospital, Spinal Surgery, London (United Kingdom); Hughes, Richard; Saifuddin, Asif [Royal National Orthopaedic Hospital, Radiology, London (United Kingdom); Fajinmi, Matilda [Royal National Orthopaedic Hospital, Histopathology, London (United Kingdom)

    2007-03-15

    Osteoblastoma is a rare primary bone tumour which is well-described in the spine and sacrum. We report a case of histologically confirmed osteoblastoma in a 20-year-old male which crossed the sacroiliac joint. This has not previously been described to our knowledge. The imaging features of osteoblastoma and sacroiliac joint involvement by bone tumours are reviewed. (orig.)

  12. A simulation method for lightning surge response of switching power

    International Nuclear Information System (INIS)

    Wei, Ming; Chen, Xiang

    2013-01-01

    In order to meet the need of protection design for lighting surge, a prediction method of lightning electromagnetic pulse (LEMP) response which is based on system identification is presented. Experiments of switching power's surge injection were conducted, and the input and output data were sampled, de-noised and de-trended. In addition, the model of energy coupling transfer function was obtained by system identification method. Simulation results show that the system identification method can predict the surge response of linear circuit well. The method proposed in the paper provided a convenient and effective technology for simulation of lightning effect.

  13. Pressure-surge mitigation methods in fluid-conveying piping

    International Nuclear Information System (INIS)

    Shin, Y.W.; Youngdahl, C.K.; Wiedermann, A.H.

    1991-01-01

    Pressure surges in the heat transport system of nuclear reactor plants can affect the safety and reliability of the plants. Hence the pressure surges must be considered in the design, operation, and maintenance of the plants in order to minimize their occurrence and impacts. The objectives of this paper are to review various methods to control or mitigate the pressure surges, to analyze these methods to gain understanding of the mitigation mechanisms, and examine applicability of the methods to nuclear power plants. 6 refs., 13 figs

  14. [Bone structure in rheumatoid arthritis].

    Science.gov (United States)

    Ono, Kumiko; Ohashi, Satoru; Tanaka, Sakae; Matsumoto, Takuya

    2013-07-01

    In rheumatoid arthritis (RA) , the osteoclast pathway is activated by abnormal immune conditions accompanied by chronic inflammation, resulting in periarticular osteoporosis and local bone destruction around joints. In addition, multiple factors, including reduced physical activity and pharmacotherapies such as steroids, lead to systemic osteoporosis. These conditions cause decreasing bone mineral density and deterioration of bone quality, and expose patients to increased risk of fracture. Understanding the bone structures of RA and evaluating fracture risk are central to the treatment of RA.

  15. Active surge control for variable speed axial compressors.

    Science.gov (United States)

    Lin, Shu; Yang, Chunjie; Wu, Ping; Song, Zhihuan

    2014-09-01

    This paper discusses active surge control in variable speed axial compressors. A compression system equipped with a variable area throttle is investigated. Based on a given compressor model, a fuzzy logic controller is designed for surge control and a proportional speed controller is used for speed control. The fuzzy controller uses measurements of the change of pressure rise as well as the change of mass flow to determine the throttle opening. The presented approach does not require the knowledge of system equilibrium or the surge line. Numerical simulations show promising results. The proposed fuzzy logic controller performs better than a backstepping controller and is capable to suppress surge at different operating points. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Assessment of storm surge disaster potential for the Andaman Islands

    Digital Repository Service at National Institute of Oceanography (India)

    Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

    . Supporting volume 1: math- ematical modelling of cyclone surge and related flooding. In: Cy- clone Damage in Bangladesh. United Nations Centre for Regional Development, pp. 9–37. DHI (Danish Hydraulic Institute), 2002. MIKE 21 Coastal Hydrau- lics...

  17. Storm surge model based on variational data assimilation method

    Directory of Open Access Journals (Sweden)

    Shi-li Huang

    2010-06-01

    Full Text Available By combining computation and observation information, the variational data assimilation method has the ability to eliminate errors caused by the uncertainty of parameters in practical forecasting. It was applied to a storm surge model based on unstructured grids with high spatial resolution meant for improving the forecasting accuracy of the storm surge. By controlling the wind stress drag coefficient, the variation-based model was developed and validated through data assimilation tests in an actual storm surge induced by a typhoon. In the data assimilation tests, the model accurately identified the wind stress drag coefficient and obtained results close to the true state. Then, the actual storm surge induced by Typhoon 0515 was forecast by the developed model, and the results demonstrate its efficiency in practical application.

  18. The joint in psoriatic arthritis.

    Science.gov (United States)

    Mortezavi, Mahta; Thiele, Ralph; Ritchlin, Christopher

    2015-01-01

    Psoriatic arthritis (PsA), a chronic inflammatory joint disease associated with psoriasis, is notable for diversity in disease presentation, course and response to treatment. Equally varied are the types of musculoskeletal involvement which include peripheral and axial joint disease, dactylitis and enthesitis. In this review, we focus on the psoriatic joint and discuss pathways that underlie synovial, cartilage and bone inflammation and highlight key histopathologic features. The pivotal inflammatory mechanisms and pathobiology of PsA parallel findings in other forms of spondyloarthritis but are distinct from disease pathways described in rheumatoid synovitis and bone disease. The diagnosis of PsA from both a clinical and imaging perspective is also discussed.

  19. Bone pathology inpsoriatic arthritis

    Directory of Open Access Journals (Sweden)

    V. V. Badokin

    2007-01-01

    Full Text Available Objective. To study different variants of osteolysis in pts with psoriatic arthritis (PA and to reveal their relationship with other clinico-radiological features of joint damage. Material and methods. 370 pts with definite PA having different variants of joint damage were included. Radiological examination of bones and joints (in some cases large picture frame was performed. Morphological evaluation of synovial biopsies was done in 34 pts with PA and 10 pts with rheumatoid arthritis (RA. Results. Different types of osteolysis were revealed in 80 (21,6% pts. Osteolytic variant of joint damage was present in 29 pts. 33 pts had acral, 48 — intra-articular osteolysis and 16 - true bone atrophy. Frequency and intensity of bone resorption were associated with severity of PA. Acral osteolysis correlated with arthritis of distal interphalangeal joints and onychodystrophy. Intra-articular osteolysis was most often present in distal interphalangeal joints of hands and metacarpophalangeal joints (39,6% and 41,7% respectively. Characteristic feature of PA was combination of prominent resorption with formation of bone ankylosis and periosteal reaction. Ankylosis was present in 33,3% of pts with intra-articular osteolysis and in 60% of pts with combination of different osteolysis variants. Systemic reaction of microcirculation in synovial biopsies was most prominent in osteolytic variant: marked thickening of capillary and venule basal membrane with high level of acid phosphatase, increased capillary and precapillary blood flow with stasis features, vascular lymphocyte and macrophage infiltration, productive vasculitis with annular wall thickening, thrombovasculitis and villi deep layer sclerosis. Conclusion. Different variants of osteolysis show bone involvement in PA. Acral and intra- articular osteolysis association with bone ankylosis and periostitis proves their common pathogenetic entity.

  20. Planning for partnerships: Maximizing surge capacity resources through service learning.

    Science.gov (United States)

    Adams, Lavonne M; Reams, Paula K; Canclini, Sharon B

    2015-01-01

    Infectious disease outbreaks and natural or human-caused disasters can strain the community's surge capacity through sudden demand on healthcare activities. Collaborative partnerships between communities and schools of nursing have the potential to maximize resource availability to meet community needs following a disaster. This article explores how communities can work with schools of nursing to enhance surge capacity through systems thinking, integrated planning, and cooperative efforts.

  1. Experimental Study on Noise Characteristic of Centrifugal Compressor Surge

    OpenAIRE

    Yang, Qichao; Zhao, Yuanyang; SHU, Yue; LI, Xiaosa; LI, Liansheng

    2016-01-01

    The centrifugal air compressor test rig is was designed and established. The experimental study was carried out on the surge characteristics of centrifugal compressor including the pressure in the pipe and the noise characteristics under different rotation speed. The tested results showed that both the suction pressure and discharge pressure fluctuation increase under surge condition and the amplitude of discharge pressure fluctuation is significantly higher than that of suction pressure. In ...

  2. Performance of Surge Arrester Installation to Enhance Protection

    Directory of Open Access Journals (Sweden)

    Mbunwe Muncho Josephine

    2017-01-01

    Full Text Available The effects of abnormal voltages on power system equipment and appliances in the home have raise concern as most of the equipments are very expensive. Each piece of electrical equipment in an electrical system needs to be protected from surges. To prevent damage to electrical equipment, surge protection considerations are paramount to a well designed electrical system. Lightning discharges are able to damage electric and electronic devices that usually have a low protection level and these are influenced by current or voltage pulses with a relatively low energy, which are induced by lightning currents. This calls for proper designed and configuration of surge arresters for protection on the particular appliances. A more efficient non-linear surge arrester, metal oxide varistor (MOV, should be introduced to handle these surges. This paper shows the selection of arresters laying more emphasis on the arresters for residential areas. In addition, application and installation of the arrester will be determined by the selected arrester. This paper selects the lowest rated surge arrester as it provides insulation when the system is under stress. It also selected station class and distribution class of arresters as they act as an open circuit under normal system operation and to bring the system back to its normal operation mode as the transient voltage is suppressed. Thus, reduces the risk of damage, which the protection measures can be characterized, by the reduction value of the economic loss to an acceptable level.

  3. MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage

    DEFF Research Database (Denmark)

    Tan, Yu M; Østergaard, Mikkel; Doyle, Anthony

    2009-01-01

    INTRODUCTION: The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA). METHODS: Twenty-eight patients with erosive PsA were enrolled (median disease duration of 14 years). Using x-rays ...

  4. Transfer of lumbosacral load to iliac bones and legs Part 1: Biomechanics of self-bracing of the sacroiliac joints and its significance for treatment and exercise

    NARCIS (Netherlands)

    C.J. Snijders (Chris); A. Vleeming (Andry); R. Stoeckart (Rob)

    1993-01-01

    textabstractThis study deals primarily with the stability of the base of the spine. The sacroiliac joints are vulnerable to shear loading on account of their predominantly flat surfaces. This raises the question of what mechanisms are brought into action to prevent dislocation of the sacroiliac

  5. Transfer of lumbosacral load to iliac bones and legs Part 2: Loading of the sacroiliac joints when lifting in a stooped posture

    NARCIS (Netherlands)

    C.J. Snijders (Chris); A. Vleeming (Andry); R. Stoeckart (Rob)

    1993-01-01

    textabstractWe developed a biomechanical model of load transfer by the sacroiliac joints in relation to posture. A description is given of two ways in which the transfer of lumbar load to the pelvis in a stooped posture can take place. One way concerns ligament and muscle forces that act on the

  6. Improved PV system reliability results from surge evaluations at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Russell H. Bonn; Sigifredo Gonzalez

    2000-01-01

    Electrical surges on ac and dc inverter power wiring and diagnostic cables have the potential to shorten the lifetime of power electronics. These surges may be caused by either nearby lightning or capacitor switching transients. This paper contains a description of ongoing surge evaluations of PV power electronics and surge mitigation hardware at Sandia

  7. Surge of a Complex Glacier System - The Current Surge of the Bering-Bagley Glacier System, Alaska

    Science.gov (United States)

    Herzfeld, U. C.; McDonald, B.; Trantow, T.; Hale, G.; Stachura, M.; Weltman, A.; Sears, T.

    2013-12-01

    Understanding fast glacier flow and glacial accelerations is important for understanding changes in the cryosphere and ultimately in sea level. Surge-type glaciers are one of four types of fast-flowing glaciers --- the other three being continuously fast-flowing glaciers, fjord glaciers and ice streams --- and the one that has seen the least amount of research. The Bering-Bagley Glacier System, Alaska, the largest glacier system in North America, surged in 2011 and 2012. Velocities decreased towards the end of 2011, while the surge kinematics continued to expand. A new surge phase started in summer and fall 2012. In this paper, we report results from airborne observations collected in September 2011, June/July and September/October 2012 and in 2013. Airborne observations include simultaneously collected laser altimeter data, videographic data, GPS data and photographic data and are complemented by satellite data analysis. Methods range from classic interpretation of imagery to analysis and classification of laser altimeter data and connectionist (neural-net) geostatistical classification of concurrent airborne imagery. Results focus on the characteristics of surge progression in a large and complex glacier system (as opposed to a small glacier with relatively simple geometry). We evaluate changes in surface elevations including mass transfer and sudden drawdowns, crevasse types, accelerations and changes in the supra-glacial and englacial hydrologic system. Supraglacial water in Bering Glacier during Surge, July 2012 Airborne laser altimeter profile across major rift in central Bering Glacier, Sept 2011

  8. Bone tumors

    International Nuclear Information System (INIS)

    Unni, K.K.

    1988-01-01

    This book contains the proceedings on bone tumors. Topics covered include: Bone tumor imaging: Contribution of CT and MRI, staging of bone tumors, perind cell tumors of bone, and metastatic bone disease

  9. Observing Storm Surges from Space: A New Opportunity

    Science.gov (United States)

    Han, Guoqi; Ma, Zhimin; Chen, Dake; de Young, Brad; Chen, Nancy

    2013-04-01

    Coastal tide gauges can be used to monitor variations of a storm surge along the coast, but not in the cross-shelf direction. As a result, the cross-shelf structure of a storm surge has rarely been observed. In this study we focus on Hurricane Igor-induced storm surge off Newfoundland, Canada. Altimetric observations at about 2:30, September 22, 2010 UTC (hours after the passage of Hurricane Igor) reveal prominent cross-shelf variation of sea surface height during the storm passage, including a large nearshore slope and a mid-shelf depression. A significant coastal surge of 1 m derived from satellite altimetry is found to be consistent with tide-gauge measurements at nearby St. John's station. The post-storm sea level variations at St. John's and Argentia are argued to be associated with free equatorward-propagating continental shelf waves (with phase speeds of 11-13 m/s), generated along the northeast Newfoundland coast hours after the storm moved away from St. John's. The cross-shelf e-folding scale of the shelf wave was estimated to be ~100 km. We further show approximate agreement of altimetric and tide-gauge observations in the Gulf of Mexico during Hurricane Katrina (2005) and Isaac (2012). The study for the first time in the literature shows the robustness of satellite altimetry to observe storm surges, complementing tide-gauge observations for the analysis of storm surge characteristics and for the validation and improvement of storm surge models.

  10. Increasing risk of compound flooding from storm surge and rainfall for major US coastal cities

    Science.gov (United States)

    Wahl, Thomas; Jain, Shaleen; Bender, Jens; Meyers, Steven; Luther, Mark

    2016-04-01

    Flood risk is a well-known facet of natural hazards along the US coastline where nearly 40% of the population resides in coastal counties. Given the heavy reliance on the coastal zone for natural resources and economic activity, flood preparedness and safety is a key element of long-term resilience. A clear understanding of the various flood types and changes in the frequency of their occurrence is critical towards reliable estimates of vulnerability and potential impacts in the near-term as well as into the future. When the two main flood drivers for coastal areas storm surge and heavy precipitation occur in tandem the potential for significant flooding is much greater than from either in isolation. Exploring the probability of these 'compound events' and understanding the processes driving them is essential to mitigate the associated high impact risks. For the contiguous US the likelihood of the joint occurrence of the two phenomena is largely unknown. Here we show - using storm surge and precipitation records spanning the last century - that the risk of compound flooding is higher for the US east and Gulf coasts, relative to the west coast. We also show that the number of compound events has increased significantly over the last century along large coastline stretches including many of the major coastal cities. For New York City - as an example - this increase is attributed to a shift towards storm surge weather patterns also favouring high precipitation. Preliminary analyses reveal that these synoptic scale changes are closely linked to large scale and low frequency climate variations. Our results demonstrate the importance of assessing the risk of compound flooding within the design process of coastal and urban infrastructure in a non-stationary framework and to explore the potential effects of climate change on these high impact events.

  11. Radiology of the hand bones. Pt. 1. Inflammative diseases of the joints and rheumatology; Radiologie des Handskeletts. T. 1. Entzuendliche Gelenkserkrankungen und Rheumatologie

    Energy Technology Data Exchange (ETDEWEB)

    Uhl, M. [Freiburg Univ. (Germany). Radiologische Klinik

    1999-05-01

    The contributions in the section on ``advanced training`` reflect the knowledge required of doctors specializing in diagnostic radiology and may also serve as a revision course for medical practicioners. It presents clinically validated information on the following subjects: Rheumatoid arthritis (radiological model) - four classes of radiological signs of arthritis - hydrarthrosis, haemarthrosis and serosynovitis - osteopenia near the joints (where direct signs may not be available until several months or years after the onset of the disease) - `signal cysts` - changes in the limiting lamina (which require careful observation under a magnifying glass) - pannus (an indication of arthritis of the joints) - mutilation - false positions of the joints. [Deutsch] Die Beitraege der Rubrik `Weiterbildung` sollen dem Stand des zur Facharztpruefung fuer den Arzt fuer Diagnostische Radiologie notwendigen Wissens entsprechen und zugleich dem niedergelassenen Facharzt als Repetitorium dienen. Die Rubrik beschraenkt sich auf klinisch gesicherte Aussagen zu den Themen: - Rheumatoide Arthritis (Radiologisches Modell) - Vier Klassen der radiologischen Arthritiszeichen. - Gelenkerguss - `Gelenknahe Osteopenie` (Direktzeichen sind erst Wochen bis Monate bzw. Jahre nach Krankheitsbeginn erkennbar.) - `Signalzysten` - Grenzlamellenveraenderungen (Sorgfaeltige Lupenbetrachtung ist entscheidend.) - Pannus (Beweis fuer eine arthritische Gelenkerkrankung.) - Mutilation - Gelenkfehlstellungen. (orig./AJ)

  12. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... replacement and fracture reductions. look for injury, infection, arthritis , abnormal bone growths and bony changes seen in ... injuries, including fractures, and joint abnormalities, such as arthritis. X-ray equipment is relatively inexpensive and widely ...

  13. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... more useful in identifying bone and joint injuries (e.g., meniscal and ligament tears in the knee, ... or suggestion into the following text box: Comment: E-mail: Area code: Phone no: Thank you! Do ...

  14. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... as spine repair/fusion, joint replacement and fracture reductions. look for injury, infection, arthritis , abnormal bone growths ... the individual patient's condition. Ultrasound imaging, which uses sound waves instead of ionizing radiation to create diagnostic ...

  15. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... taken of the unaffected limb, or of a child's growth plate (where new bone is forming), for ... around joints, and in evaluating the hips of children with congenital problems. top of page This page ...

  16. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... view and assess bone fractures, injuries and joint abnormalities. This exam requires little to no special preparation. ... follow-up exam is done because a potential abnormality needs further evaluation with additional views or a ...

  17. Proposed Strategies for DWPF Melter Off-Gas Surge Control

    International Nuclear Information System (INIS)

    CHOI, ALEXANDERS.

    2004-01-01

    Off-gas surging is inherent to the operation of slurry-fed melters. Although the melter design and the feed chemistry are both known to significantly affect off-gas surging, the frequency and intensity of surges are in essence unpredictable. In typical off-gas surges, both condensable and non condensable flows spike simultaneously. Condensable or steam surges have been observed to occur as the boiling water layer occasionally falls into the crevices of the cold cap or flows over the edges of the cold cap, thereby coming in contact with the melt surface. The resulting steam surges can pressurize the melter considerably and, therefore, are responsible for the bulk of pressure transients that propagate throughout the off-gas system. The non condensable surges occur as the calcine gases that have been accumulating within the cold cap finally build up enough pressure to be released through the temporary openings of the cold cap. The analysis of off-gas data has shown that over 90 of the gas released during a surge is due to steam.1 Therefore, it is essential to have a large inventory of water in the cold cap for any significant pressure spikes to occur. With the Melter 2 vapor space temperature typically running at 720C, the water layer in the cold cap will quickly evaporate once the feeding stops, and the potential for any large pressure spikes should practically cease to exist. The analysis also showed that large pressure spikes well above 2 inches H2O cannot occur under the steam surge scenarios described above. More severe conditions should prevail and one such condition would be that the feed materials form a mound with a growing lake on top, while the melt below remains very fluidic due to its low viscosity, thus resulting in greater movements both in the lateral as well as vertical directions. Once the mound begins to grow, its rate should accelerate, since the heat transfer rate to the upper regions of the cold cap is inversely proportional to the cold cap

  18. Tropical cyclone induced asymmetry of sea level surge and fall and its presentation in a storm surge model with parametric wind fields

    Science.gov (United States)

    Peng, Machuan; Xie, Lian; Pietrafesa, Leonard J.

    The asymmetry of tropical cyclone induced maximum coastal sea level rise (positive surge) and fall (negative surge) is studied using a three-dimensional storm surge model. It is found that the negative surge induced by offshore winds is more sensitive to wind speed and direction changes than the positive surge by onshore winds. As a result, negative surge is inherently more difficult to forecast than positive surge since there is uncertainty in tropical storm wind forecasts. The asymmetry of negative and positive surge under parametric wind forcing is more apparent in shallow water regions. For tropical cyclones with fixed central pressure, the surge asymmetry increases with decreasing storm translation speed. For those with the same translation speed, a weaker tropical cyclone is expected to gain a higher AI (asymmetry index) value though its induced maximum surge and fall are smaller. With fixed RMW (radius of maximum wind), the relationship between central pressure and AI is heterogeneous and depends on the value of RMW. Tropical cyclone's wind inflow angle can also affect surge asymmetry. A set of idealized cases as well as two historic tropical cyclones are used to illustrate the surge asymmetry.

  19. Methodology for surge pressure evaluation in a water injection system

    Energy Technology Data Exchange (ETDEWEB)

    Meliande, Patricia; Nascimento, Elson A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Dept. de Engenharia Civil; Mascarenhas, Flavio C.B. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Hidraulica Computacional; Dandoulakis, Joao P. [SHELL of Brazil, Rio de Janeiro, RJ (Brazil)

    2009-07-01

    Predicting transient effects, known as surge pressures, is of high importance for offshore industry. It involves detailed computer modeling that attempts to simulate the complex interaction between flow line and fluid in order to ensure efficient system integrity. Platform process operators normally raise concerns whether the water injection system is adequately designed or not to be protected against possible surge pressures during sudden valve closure. This report aims to evaluate the surge pressures in Bijupira and Salema water injection systems due to valve closure, through a computer model simulation. Comparisons among the results from empirical formulations are discussed and supplementary analysis for Salema system were performed in order to define the maximum volumetric flow rate for which the design pressure was able to withstand. Maximum surge pressure values of 287.76 bar and 318.58 bar, obtained in Salema and Bijupira respectively, using empirical formulations have surpassed the operating pressure design, while the computer model results have pointed the greatest surge pressure value of 282 bar in Salema system. (author)

  20. Developing models for patient flow and daily surge capacity research.

    Science.gov (United States)

    Asplin, Brent R; Flottemesch, Thomas J; Gordon, Bradley D

    2006-11-01

    Between 1993 and 2003, visits to U.S. emergency departments (EDs) increased by 26%, to a total of 114 million visits annually. At the same time, the number of U.S. EDs decreased by more than 400, and almost 200,000 inpatient hospital beds were taken out of service. In this context, the adequacy of daily surge capacity within the system is clearly an important issue. However, the research agenda on surge capacity thus far has focused primarily on large-scale disasters, such as pandemic influenza or a serious bioterrorism event. The concept of daily surge capacity and its relationship to the broader research agenda on patient flow is a relatively new area of investigation. In this article, the authors begin by describing the overlap between the research agendas on daily surge capacity and patient flow. Next, they propose two models that have potential applications for both daily surge capacity and hospitalwide patient-flow research. Finally, they identify potential research questions that are based on applications of the proposed research models.

  1. Surge recovery techniques for the Tevatron cold compressors

    International Nuclear Information System (INIS)

    Martinez, A.; Klebaner, A.L.; Makara, J.N.; Theilacker, J.C.; Fermilab

    2006-01-01

    The Fermilab Tevatron cryogenic system utilizes high-speed centrifugal cold compressors, made by Ishikawajima-Harima Heavy Industries Co. Ltd. (IHI), for high-energy operations [1]. The compressor is designed to pump 60 g/s of 3.6 K saturated helium vapor at a pressure ratio of 2.8, with an off-design range of 40 to 70 g/s and operating speeds between 40 and 95 krpm. Since initial commissioning in 1993, Tevatron transient conditions such as quench recovery have led to multiple-location machine trips as a result of the cold compressors entering the surge regime. Historically, compressors operating at lower inlet pressures and higher speeds have been especially susceptible to these machine trips and it was not uncommon to have multiple compressor trips during large multiple-house quenches. In order to cope with these events and limit accelerator down time, surge recovery techniques have been implemented in an attempt to prevent the compressors from tripping once the machine entered this surge regime. This paper discusses the different methods of surge recovery that have been employed. Data from tests performed at the Cryogenic Test Facility at Fermilab as well as actual Tevatron operational data were utilized. In order to aid in the determination of the surge region, a full mapping study was undertaken to characterize the entire pressure field of the cold compressor. These techniques were then implemented and tested at several locations in the Tevatron with some success

  2. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors

    International Nuclear Information System (INIS)

    Brien, E.W.; Mirra, J.M.; Luck, J.V. Jr.

    1999-01-01

    In part I, we reviewed the varied clinical presentations, pathogenesis, histologic findings, radiologic findings, and treatment of intramedullary cartilaginous lesions of bone. In this section, we will evaluate our cases and consultations of juxtacortical cartilaginous tumors. Radiographic differential diagnosis includes the numerous juxtacortical lesions particularly osteochondroma, parosteal chondroma, Trevor's disease, trauma (fracture and periostitis ossificans), and the low- and high-grade surface osteosarcomas. By emphasizing pathogenesis in conjunction with radiographic and histologic findings, pitfalls in diagnosis and subsequent treatment can be avoided in such cases. (orig.)

  3. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors

    Energy Technology Data Exchange (ETDEWEB)

    Brien, E.W. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)]|[Musculoskeletal Tumor Service, Orthopaedic Hospital, Los Angeles, CA (United States); Mirra, J.M.; Luck, J.V. Jr. [Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles, CA (United States)

    1999-01-01

    In part I, we reviewed the varied clinical presentations, pathogenesis, histologic findings, radiologic findings, and treatment of intramedullary cartilaginous lesions of bone. In this section, we will evaluate our cases and consultations of juxtacortical cartilaginous tumors. Radiographic differential diagnosis includes the numerous juxtacortical lesions particularly osteochondroma, parosteal chondroma, Trevor`s disease, trauma (fracture and periostitis ossificans), and the low- and high-grade surface osteosarcomas. By emphasizing pathogenesis in conjunction with radiographic and histologic findings, pitfalls in diagnosis and subsequent treatment can be avoided in such cases. (orig.) With 32 figs., 2 tabs., 32 refs.

  4. A numerical storm surge forecast model with Kalman filter

    Institute of Scientific and Technical Information of China (English)

    Yu Fujiang; Zhang Zhanhai; Lin Yihua

    2001-01-01

    Kalman filter data assimilation technique is incorporated into a standard two-dimensional linear storm surge model. Imperfect model equation and imperfect meteorological forcimg are accounted for by adding noise terms to the momentum equations. The deterministic model output is corrected by using the available tidal gauge station data. The stationary Kalman filter algorithm for the model domain is calculated by an iterative procedure using specified information on the inaccuracies in the momentum equations and specified error information for the observations. An application to a real storm surge that occurred in the summer of 1956 in the East China Sea is performed by means of this data assimilation technique. The result shows that Kalman filter is useful for storm surge forecast and hindcast.

  5. Electromagnetic computation methods for lightning surge protection studies

    CERN Document Server

    Baba, Yoshihiro

    2016-01-01

    This book is the first to consolidate current research and to examine the theories of electromagnetic computation methods in relation to lightning surge protection. The authors introduce and compare existing electromagnetic computation methods such as the method of moments (MOM), the partial element equivalent circuit (PEEC), the finite element method (FEM), the transmission-line modeling (TLM) method, and the finite-difference time-domain (FDTD) method. The application of FDTD method to lightning protection studies is a topic that has matured through many practical applications in the past decade, and the authors explain the derivation of Maxwell's equations required by the FDTD, and modeling of various electrical components needed in computing lightning electromagnetic fields and surges with the FDTD method. The book describes the application of FDTD method to current and emerging problems of lightning surge protection of continuously more complex installations, particularly in critical infrastructures of e...

  6. Community health facility preparedness for a cholera surge in Haiti.

    Science.gov (United States)

    Mobula, Linda Meta; Jacquet, Gabrielle A; Weinhauer, Kristin; Alcidas, Gladys; Thomas, Hans-Muller; Burnham, Gilbert

    2013-01-01

    With increasing population displacement and worsening water insecurity after the 2010 earthquake, Haiti experienced a large cholera outbreak. Our goal was to evaluate the strengths and weaknesses of seven community health facilities' ability to respond to a surge in cholera cases. Since 2010, Catholic Relief Services (CRS) with a number of public and private donors has been working with seven health facilities in an effort to reduce morbidity and mortality from cholera infection. In November 2012, CRS through the Centers for Disease Control and Prevention (CDC)'s support, asked the Johns Hopkins Center for Refugee and Disaster Response to conduct a cholera surge simulation tabletop exercise at these health facilities to improve each facility's response in the event of a cholera surge. Using simulation development guidelines from the Pan American Health Organization and others, a simulation scenario script was produced that included situations of differing severity, supply chain, as well as a surge of patients. A total of 119 hospital staff from seven sites participated in the simulation exercise including community health workers, clinicians, managers, pharmacists, cleaners, and security guards. Clinics that had challenges during the simulated clinical care of patients were those that did not appropriately treat all cholera patients according to protocol, particularly those that were vulnerable, those that would need additional staff to properly treat patients during a surge of cholera, and those that required a better inventory of supplies. Simulation-based activities have the potential to identify healthcare delivery system vulnerabilities that are amenable to intervention prior to a cholera surge.

  7. Effect of switching surges on ehv system design

    Energy Technology Data Exchange (ETDEWEB)

    Baril, G A; McGillis, D

    1966-01-01

    The presence of switching surges imposes certain conditions on the design of ehv system and certain resulting requirements in the basic components of these systems. At extra high voltage, it becomes both a practical as well as an economic necessity to limit the magnitude of switching surge overvoltages. This can be accomplished by the installation of suitable terminal equipment, and for the 735 kV system it was found necessary to install permanently connected shunt reactors on the transmission lines and to provide for the installation of closing resistors on the circuit breakers.

  8. Investigation of surge protective devices operation of a wind generator

    International Nuclear Information System (INIS)

    Dimitrov, D.; Vasileva, M.

    2008-01-01

    The interest to the investments in a wind energetics increases in the last years. The wind energetics is the fastest developing direction in the energetics in global scale. The wind energy is more attractive because its prices are lower in comparison of the other technologies for generating energy. The right choice of the surge protective devices has the important meaning on building and exploitation of the wind generators. The aim of this paper is investigation of the surge protective devices operation when they are installation to a wind generator. (authors)

  9. Ten-Year Follow-Up of Desarthrodesis of the Knee Joint 41 Years after Original Arthrodesis for a Bone Tumor

    Directory of Open Access Journals (Sweden)

    Ahmed Hamed Kassem Abdelaal

    2015-01-01

    Full Text Available Introduction. The main indication for knee arthrodesis in tumor surgery is a tumor that requires an extensive resection in which the joint surface cannot be preserved. We report a patient that had knee desarthrodesis 41 years after giant cell tumor resection followed by a knee arthrodesis. This is the longest reported follow-up after desarthrodesis and conversion to total knee arthroplasty (TKA, almost ten years. Case Report. A 71-year-old man with a distal femoral giant cell tumor had undergone a resection of the distal femur and knee arthrodesis using Kuntscher nail in 1962. In July 2003 he experienced gradually increasing pain of his left knee. We performed a desarthrodesis and conversion to TKA in 2005. The postoperative period passed uneventfully as his pain and gait improved, with gradually increasing range of motion (ROM and no infection. He now walks independently, with no brace or contractures. Conclusion. Desarthrodesis of the knee joint and conversion to TKA are a difficult surgical choice with a high complication risk. However, our patient’s life style has improved, he has no pain, and he can ascend and descend stairs more easily. The surgeon has to be very meticulous in selecting a patient for knee arthrodesis and counseling them to realize that their expectations may not be achievable.

  10. Value of bone scintigraphy in psoriasis

    International Nuclear Information System (INIS)

    Nakayama, Chikashi; Nakata, Hajime; Kimoto, Tatsuya; Nakayama, Takashi; Yokomizo, Yu

    1982-01-01

    We performed bone scintigraphy on 16 cases of psoriasis to evaluate its possible value in this disease and obtained the following results: 1) Bone scintigraph was abnormal in 15 of 16 cases and the frequent association of arthritis in psoriasis was confirmed. 2) Abnormal uptake on bone scintigraph was noted in various joints including peripheral joints of extremities, sternoclavicular joint, shoulder and rib. Abnormality of sacroiliac joint or ankle was less frequent than previously reported. 3) Findings of bone scintigraph were not necessarily related with clinical symptoms or laboratory data. Abnormal uptake was also noted in many joints whose X-ray examinations were negative. Bone scintigraphy thus seems to be useful in early detection of arthritis and to become an initial therapeutic indicator of arthritis in psoriasis. (author)

  11. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... be more useful in identifying bone and joint injuries (e.g., meniscal and ligament tears in the knee, rotator cuff and labrum tears in the shoulder) and in imaging of the spine (because both the bones and the spinal cord can be evaluated). MRI can also detect subtle ...

  12. [Biomaterials in bone repair].

    Science.gov (United States)

    Puska, Mervi; Aho, Allan J; Vallittu, Pekka K

    2013-01-01

    In orthopedics, traumatology, and craniofacial surgery, biomaterials should meet the clinical demands of bone that include shape, size and anatomical location of the defect, as well as the physiological load-bearing stresses. Biomaterials are metals, ceramics, plastics or materials of biological origin. In the treatment of large defects, metallic endoprostheses or bone grafts are employed, whereas ceramics in the case of small defects. Plastics are employed on the artificial joint surfaces, in the treatment of vertebral compression fractures, and as biodegradable screws and plates. Porosity, bioactivity, and identical biomechanics to bone are fundamental for achieving a durable, well-bonded, interface between biomaterial and bone. In the case of severe bone treatments, biomaterials should also imply an option to add biologically active substances.

  13. Surge Protection in Low-Voltage AC Power Circuits: An Anthology

    Science.gov (United States)

    Martzloff, F. D.

    2002-10-01

    The papers included in this part of the Anthology provide basic information on the propagation of surges in low-voltage AC power circuits. The subject was approached by a combination of experiments and theoretical considerations. One important distinction is made between voltage surges and current surges. Historically, voltage surges were the initial concern. After the introduction and widespread use of current-diverting surge-protective devices at the point-of-use, the propagation of current surges became a significant factor. The papers included in this part reflect this dual dichotomy of voltage versus current and impedance mismatch effects versus simple circuit theory.

  14. Hospital-Based Coalition to Improve Regional Surge Capacity

    Directory of Open Access Journals (Sweden)

    James M. Learning

    2012-12-01

    Full Text Available Introduction: Surge capacity for optimization of access to hospital beds is a limiting factor in response to catastrophic events. Medical facilities, communication tools, manpower, and resource reserves exist to respond to these events. However, these factors may not be optimally functioning to generate an effective and efficient surge response. The objective was to improve the function of these factors.Methods: Regional healthcare facilities and supporting local emergency response agencies developed a coalition (the Healthcare Facilities Partnership of South Central Pennsylvania; HCFP¬SCPA to increase regional surge capacity and emergency preparedness for healthcare facilities. The coalition focused on 6 objectives: (1 increase awareness of capabilities and assets, (2 develop and pilot test advanced planning and exercising of plans in the region, (3 augment written medical mutual aid agreements, (4 develop and strengthen partnership relationships, (5 ensure National Incident Management System compliance, and (6 develop and test a plan for effective utilization of volunteer healthcare professionals.Results: In comparison to baseline measurements, the coalition improved existing areas covered under all 6 objectives documented during a 24-month evaluation period. Enhanced communications between the hospital coalition, and real-time exercises, were used to provide evidence of improved preparedness for putative mass casualty incidents.Conclusion: The HCFP-SCPA successfully increased preparedness and surge capacity through a partnership of regional healthcare facilities and emergency response agencies.

  15. Surge and selection: power in the refugee resettlement regime

    OpenAIRE

    Annelisa Lindsay

    2017-01-01

    There is an imbalance of power – and a resulting lack of agency for refugees – in the structure of the current resettlement regime. The top-down process of selection also poses ethical dilemmas, as recent surges in resettlement operations show.

  16. Model simulation of storm surge potential for Andaman islands

    Digital Repository Service at National Institute of Oceanography (India)

    Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

    Hydraulics and Oceanography, the Hydrodynamics Module Reference Manual. DHI Water and Environment, Horsholm, Denmark, 58 p. Dube, S.K., Sinha, P C , Rao, A.D., and Rao, G.S., 1985. Numerical modeling of storm surges in the Arabian Sea, Appl. Math Modelling, 9...

  17. Multidimensional Numerical Modeling of Surges Over Initially Dry Land

    National Research Council Canada - National Science Library

    Berger, R

    2004-01-01

    .... The first test case is for a straight flume and the second contains a reservoir and a horseshoe channel section. It is important that the model match the timing of the surge as well as the height In both cases the ADH compared closely with the flume results.

  18. Into the Surge of Network-driven Innovation

    DEFF Research Database (Denmark)

    Østergaard, Claus Møller; Rosenstand, Claus Andreas Foss; Gertsen, Frank

    2013-01-01

    this is examined from the 1880’s up until today. The contribution of the paper is a societal perspective on innovation, where the difference between industrial society and knowledge society leads into the surge of network-driven innovation. Network-driven innovation is unfolded on top of the known cost- driven...

  19. Surge of plasma waves in an inhomogeneous plasma

    International Nuclear Information System (INIS)

    Benhassine, Mohammed

    1985-01-01

    The first part of this research thesis addresses the propagation of waves in a plasma. It presents the equation of propagation of an electromagnetic wave in a plasma without magnetic field, and analyses the propagation in an inhomogeneous medium. The second part addresses the wave-particle interaction: interaction between electrons and an electromagnetic wave, between electrons and an electrostatic wave (trapping), and between electrons and a localised electric field. The third chapter presents the analytic theory of oscillations of a cold plasma (macroscopic equations in Lagrangian coordinates, analytic solution before surge). The next chapter discusses physical interpretations before the wave surge, after the wave surge, and about energy exchange (within or outside of resonance). Numerical simulations and their results are then reported and discussed. The sixth chapter addresses the case of an electrostatic wave surge in a hot plasma. It notably addresses the following aspects: equivalence between the description of moments and the Waterbag model, interaction between non linearity and thermal effects, variation of electric field amplitude with temperature. Results of numerical simulations are presented, and the last part addresses experimental predictions for microwaves-plasma interaction and laser-matter interaction [fr

  20. On the Response of Interleaved Transformer Windings to Surge Voltages

    DEFF Research Database (Denmark)

    Pedersen, A.

    1963-01-01

    The high series capacitance theory for the response of interleaved transformer windings to surge voltages is criticized from the point of view that an increased series capacitance as a result of interleaving is incompatible with the concept of a pure capacitive initial voltage distribution. A new...

  1. Surge ammonium uptake in macroalgae from a coral atoll

    Digital Repository Service at National Institute of Oceanography (India)

    Raikar, V.; Wafar, M.V.M.

    of Phycology 36, 680?685. Crossland, C.J., Hatcher, B.G., Smith, S.V., 1991. Role of coral reefs in global ocean production. Coral Reefs 10, 55-64. Danilo, Dy. T., Yap, H.T., 2001. Surge ammonium uptake of the cultured seaweed, Kappaphycus alvarezii (Doty...

  2. Monitoring Inland Storm Surge and Flooding from Hurricane Rita

    Science.gov (United States)

    McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.

    2006-01-01

    Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

  3. Evaluation of surge transferred overvoltages in distribution transformers

    NARCIS (Netherlands)

    Popov, M.; Sluis, van der L.; Smeets, R.P.P.

    2008-01-01

    The paper presents an analysis of very fast-transient overvoltages that occur because of the capacitive surge transfer from the high-voltage (HV) transformer winding to the low-voltage (LV) transformer winding. The study is done on a 6.6 kV single-phase test transformer. By applying a pulse with a

  4. Tide-surge Interaction Intensified by the Taiwan Strait

    Science.gov (United States)

    Zhang, Wen-Zhou; Shi, Fengyan; Hong, Hua-Sheng; Shang, Shao-Ping; Kirby, James T.

    2010-06-01

    The Taiwan Strait is a long and wide shelf-channel where the hydrodynamics is extremely complex, being characterized by strong tides, and where storm surges frequently occur during the typhoon season. Obvious oscillations due to tide-surge interaction were observed by tide gauges along the northern Fujian coast, the west bank of the Taiwan Strait, during Typhoon Dan (1999). Numerical experiments indicate that nonlinear bottom friction (described by the quadratic formula) is a major factor to predict these oscillations while the nonlinear advective terms and the shallow water effect have little contribution. It is found that the tide-surge interaction in the northern portion of the Taiwan Strait is intensified by the strait. Simulations based on simplified topographies with and without the island of Taiwan show that, in the presence of the island, the channel effect strengthens tidal currents and tends to align the major axes of tidal ellipses along the channel direction. Storm-induced currents are also strengthened by the channel. The pattern of strong tidal currents and storm-induced currents along the channel direction enhances tide-surge interaction via the nonlinear bottom friction, resulting in the obvious oscillations along the northern Fujian coast.

  5. 14 CFR 33.65 - Surge and stall characteristics.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Surge and stall characteristics. 33.65 Section 33.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... stall characteristics. When the engine is operated in accordance with operating instructions required by...

  6. 30 CFR 77.209 - Surge and storage piles.

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Surface... a reclaiming area or in any other area at or near a surge or storage pile where the reclaiming...

  7. Surge control of the electrically driven centrifugal compressor

    NARCIS (Netherlands)

    Boinov, K.O.; Lomonova, E.A.; Vandenput, A.J.A.; Tyagounov, A.

    2006-01-01

    This paper presents a method of the energy efficiency and the operational performance improvement of the electrically driven air compression system. The key innovation of the proposed method-the active surge suppression of the centrifugal compressor by means of the speed control of the electrical

  8. Aging assessment of surge protective devices in nuclear power plants

    International Nuclear Information System (INIS)

    Davis, J.F.; Subudhi, M.; Carroll, D.P.

    1996-01-01

    An assessment was performed to determine the effects of aging on the performance and availability of surge protective devices (SPDs), used in electrical power and control systems in nuclear power plants. Although SPDs have not been classified as safety-related, they are risk-important because they can minimize the initiating event frequencies associated with loss of offsite power and reactor trips. Conversely, their failure due to age might cause some of those initiating events, e.g., through short circuit failure modes, or by allowing deterioration of the safety-related component(s) they are protecting from overvoltages, perhaps preventing a reactor trip, from an open circuit failure mode. From the data evaluated during 1980--1994, it was found that failures of surge arresters and suppressers by short circuits were neither a significant risk nor safety concern, and there were no failures of surge suppressers preventing a reactor trip. Simulations, using the ElectroMagnetic Transients Program (EMTP) were performed to determine the adequacy of high voltage surge arresters

  9. Porous surface modified bioactive bone cement for enhanced bone bonding.

    Directory of Open Access Journals (Sweden)

    Qiang He

    bone cement for prosthetic fixation in total joint replacement.

  10. Distribution of auroral surges in the evening sector

    International Nuclear Information System (INIS)

    Kidd, S.R.; Rostoker, G.

    1991-01-01

    Over the past dacades a large statistical data base has been gathered consisting of both ground-based magnetometer and all-sky camera records from which researchers have inferred the distribution of substorm expansive phase events across the nighttime sector. Almost without exception, the activity distribution has been based on single station data acquired over periods of years. However, to truly establish the occurrence frequency of substorm expansive phase events, it is necessary to view the entire nighttime sector instantaneously in the light of evidence which shows that more than one expansive phase disturbance can be in progress across the broad expanse of the evening sector. In this paper, the authors study the distribution of regions of localized auroral luminosity in the poleward portion of the evening sectorauroral oval using images in the ultraviolet portion of the auroral spectrum acquired by the Viking satellite over 9 months in 1986. They find that auroral surge activity peaks in the hour before local magnetic midnight, with the probability of detecting a surge steadily decreasing to 10% of the probability of finding a surge in the hour prior to midnight as one moves westward towards 1,900 MLT. They show that their conclusion is not dependent on the threshold chosen for surge identification over a reasonable portion of the intensity range covered by the Viking imager. They further show that for the interval of several months near sunspot minimum in 1986 there is better than a 90% chance that no surge will be detected in a 1-hour range of magnetic local time if one were to sample that segment of the auroral oval at any arbitrary time

  11. Assessment of water pipes durability under pressure surge

    Science.gov (United States)

    Pham Ha, Hai; Minh, Lanh Pham Thi; Tang Van, Lam; Bulgakov, Boris; Bazhenova, Soafia

    2017-10-01

    Surge phenomenon occurs on the pipeline by the closing valve or pump suddenly lost power. Due to the complexity of the water hammer simulation, previous researches have only considered water hammer on the single pipe or calculation of some positions on water pipe network, it have not been analysis for all of pipe on the water distribution systems. Simulation of water hammer due to closing valve on water distribution system and the influence level of pressure surge is evaluated at the defects on pipe. Water hammer on water supply pipe network are simulated by Water HAMMER software academic version and the capacity of defects are calculated by SINTAP. SINTAP developed from Brite-Euram projects in Brussels-Belgium with the aim to develop a process for assessing the integrity of the structure for the European industry. Based on the principle of mechanical fault, indicating the size of defects in materials affect the load capacity of the product in the course of work, the process has proposed setting up the diagram to fatigue assessment defect (FAD). The methods are applied for water pipe networks of Lien Chieu district, Da Nang city, Viet Nam, the results show the affected area of wave pressure by closing the valve and thereby assess the greatest pressure surge effect to corroded pipe. The SINTAP standard and finite element mesh analysis at the defect during the occurrence of pressure surge which will accurately assess the bearing capacity of the old pipes. This is one of the bases to predict the leakage locations on the water distribution systems. Amount of water hammer when identified on the water supply networks are decreasing due to local losses at the nodes as well as the friction with pipe wall, so this paper adequately simulate water hammer phenomena applying for actual water distribution systems. The research verified that pipe wall with defect is damaged under the pressure surge value.

  12. Joint ventures

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    Afhandlingen analysere de konkurrenceretlige og selskabsretlige regler som er bestemmende for hvordan et joint venture samarbejde er struktureret......Afhandlingen analysere de konkurrenceretlige og selskabsretlige regler som er bestemmende for hvordan et joint venture samarbejde er struktureret...

  13. [Research of repairing rabbit knee joint cartilage defect by compound material of fibrin glue and decalcified bone matrix (DBM) and chondrocytes].

    Science.gov (United States)

    He, Jie; Yang, Xiang; Yue, Peng-ju; Wang, Guan-yu; Guo, Ting; Zhao, Jian-ning

    2009-07-01

    To investigate the feasibility and effectivity of using compound material of fibrin glue and DBM as scaffolds for cartilage tissue engineering. Chondrocytes isolated from articular cartilage were seeded into prepared scaffolds, after incubation for 4 weeks in vitro. Chondrocytes and fibrin glue and DBM constructs were implanted in the joint cave of rabbit. The specimens were excised at the 4th, 8th, 12th week, examined grossly analyzed by haematoxylin cosine, toluidine blues staining and type II collagen immunohistochemistry reaction. Wakitani score was counted to evaluate the repairing effect. Grossly analysis showed some ivory tissue filled the caves after 4 weeks and the caves were full filled with smooth surface after 12 weeks. The microscope showed a good deal of chondrocytes appeared after 8 weeks and more type II collagen than 4 weeks. Twelve weeks later, cartilage lacuna could be observed. The cells arrangement and the amount of type II collagen both showed the same as the natural one. Complicated material of fibrin glue and DBM as scaffolds can be used as scaffolds for cartilage tissue engineering.

  14. Coracoclavicular joint

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kun Sang; Park, Chan Il; Ahn, Jae Doo; Lim, Chong Won [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1970-10-15

    The coracoclvicular joint, a rear abnormality which may be the cause of pain in the shoulder and limitation of motion of the shoulder joint, is discussed. A case of coracoclvicular joint with shoulder pain was observed in 65 yrs old Korean male.

  15. Bone and Gallium scintigraphy in primary malignant and benign bone tumors of the extremities

    International Nuclear Information System (INIS)

    Sepahdari, S.; Martin, W.B.; Ryan, J.; Simon, M.; Kirchner, P.

    1985-01-01

    A six yer prospective evaluation of 129 patients suspected of having a primary bone tumor included Tc-99m MDP bone scintigraphy followed by Ga-67 imaging at 48-72 hours. Blood pool images were part of bone scintigraphy in nearly half of the patients. Extent and intensity of tracer uptake in tumor and adjacent bone and joints were recorded for each tracer by two observers blind to the diagnosis. Tissue samples obtained in every patient by biopsy or tumor excision after scintigraphy, revealed 72 malignant and 57 benign bone tumors. The bone scan was positive in 95% (69/72) of malignancies. The scintigraphic intensity of benign and malignant lesions was comparable with both Tc-99m MDP and Ga-67. On the other hand, bone scintigraphy showed 72% (52/72) of bone malignancies to have abnormal proximal and distal bone/joint uptake whereas the Ga-67 images revealed this in only 6% (4/65) of malignancies. Benign lesions manifested this enhanced contiguous bone/joint uptake on only 8% (5/55) of bone and 0% of Ga-67 scans. This study concludes positive bone, blood pool, or Ga-67 images have less specificity for malignancy than the presence of increased Tc-99m MDP deposition in a contiguous bone/joint, but negative scintigraphic results strongly favor a benign lesion. Ga-67 was more accurate than Tc-99m MDP in portraying intraosseous extent of malignant tumors; however, this is now preferably done with C.T

  16. Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

    OpenAIRE

    Xue Jin; Xiaoxia Shi; Jintian Gao; Tongbin Xu; Kedong Yin

    2018-01-01

    Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is di...

  17. A Numerical Simulation of Extratropical Storm Surge and Hydrodynamic Response in the Bohai Sea

    OpenAIRE

    Ding, Yumei; Ding, Lei

    2014-01-01

    A hindcast of typical extratropical storm surge occurring in the Bohai Sea in October 2003 is performed using a three-dimensional (3D) Finite Volume Coastal Ocean Model (FVCOM). The storm surge model is forced by 10 m winds obtained from the Weather Research Forecasting (WRF) model simulation. It is shown that the simulated storm surge and tides agree well with the observations. The nonlinear interaction between the surge and astronomical tides, the spatial distribution of the max...

  18. Caisson disease of bone.

    Science.gov (United States)

    Gregg, P J; Walder, D N

    1986-09-01

    Caisson disease of bone, which may affect compressed air workers and divers, is characterized by regions of bone and marrow necrosis that may lead to secondary osteoarthrosis of the hip and shoulder joints. A review of the pathologic, radiologic, and clinical aspects demonstrated uncertainties in the exact etiology. Early diagnosis is often not possible because of the delayed appearance of radiologic abnormalities. Research into these two aspects of this condition was carried out by the Medical Research Council Decompression Sickness Research Team in Newcastle upon Tyne over a ten-year period (1972 to 1982). Because no suitable animal model exists for the study of this condition, bone and marrow necrosis was produced by embolism of bone blood vessels with glass microspheres. With this model, it was shown that the presence of bone and marrow necrosis could be detected by bone scintigraphy using 99mTc-MDP and by measuring changes in serum ferritin concentration at a much earlier stage than was possible by radiography. However, only the former method has proved useful in clinical practice. Investigations into the etiology of caisson disease of bone have shown evidence for an increase in marrow fat cell size resulting from hyperoxia. This phenomenon may play a role in the production and localization of gas bubble emboli, which are thought to be the cause of the bone and marrow necrosis.

  19. Determining Storm Surge Return Periods: The Use of Evidence of Historic Events

    DEFF Research Database (Denmark)

    Madsen, Kristine S.; Sørensen, Carlo Sass; Schmith, Torben

    Storm surges are a major concern for many coastal communities, and rising levels of surges is a key concern in relation to climate change. The sea level of a statistical 100-year or 1000-year storm surge event and similar statistical measures are used for spatial planning and emergency preparedness...

  20. 30 CFR 56.16002 - Bins, hoppers, silos, tanks, and surge piles.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... MINES Materials Storage and Handling § 56.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored, handled or...

  1. 30 CFR 57.16002 - Bins, hoppers, silos, tanks, and surge piles.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... NONMETAL MINES Materials Storage and Handling § 57.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored, handled...

  2. Coastal Storm Surge Analysis: Storm Forcing. Report 3. Intermediate Submission No. 1.3

    Science.gov (United States)

    2013-07-01

    The storm surge study considers both tropical storms and extratropical cyclones for determination of return period storm surge elevations. The...Appendix B: Extratropical Cyclone Selection in Support of FEMA Region III Storm Surge Modeling...stations applied in the storm selection process. ............................................. 56  Table B2. Extratropical cyclones selected from the

  3. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative.

    Science.gov (United States)

    Nelson, Amanda E; Allen, Kelli D; Golightly, Yvonne M; Goode, Adam P; Jordan, Joanne M

    2014-06-01

    Although a number of osteoarthritis (OA) management guidelines exist, uptake has been suboptimal. Our aim was to review and critically evaluate existing OA management guidelines to better understand potential issues and barriers. A systematic review of the literature in MEDLINE published from January 1, 2000 to April 1, 2013 was performed and supplemented by bibliographic reviews, following PRISMA guidelines and a written protocol. Following initial title and abstract screening, 2 authors independently reviewed full-text articles; a third settled disagreements. Two independent reviewers extracted data into a standardized form. Two authors independently assessed guideline quality using the AGREE II instrument; three generated summary recommendations based on the extracted guideline data. Overall, 16 articles were included in the final review. There was broad agreement on recommendations by the various organizations. For non-pharmacologic modalities, education/self-management, exercise, weight loss if overweight, walking aids as indicated, and thermal modalities were widely recommended. For appropriate patients, joint replacement was recommended; arthroscopy with debridement was not recommended for symptomatic knee OA. Pharmacologic modalities most recommended included acetaminophen/paracetamol (first line) and NSAIDs (topical or oral, second line). Intra-articular corticosteroids were generally recommended for hip and knee OA. Controversy remains about the use of acupuncture, knee braces, heel wedges, intra-articular hyaluronans, and glucosamine/chondroitin. The relative agreement on many OA management recommendations across organizations indicates a problem with dissemination and implementation rather than a lack of quality guidelines. Future efforts should focus on optimizing implementation in primary care settings, where the majority of OA care occurs. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Antibacterial glass and glass-biodegradable matrix composites for bone tissue engineering

    OpenAIRE

    Fernandes, João Pedro Silva

    2017-01-01

    Multiple joint and bone diseases affect millions of people worldwide. In fact the Bone and Joint Decade’s association predicted that the percentage of people over 50 years of age affected by bone diseases will double by 2020. Bone diseases commonly require the need for surgical intervention, often involving partial or total bone substitution. Therefore biodegradable biomaterials designed as bone tissue engineered (BTE) devices to be implanted into the human body, function as a ...

  5. Positive modulator of bone morphogenic protein-2

    Science.gov (United States)

    Zamora, Paul O [Gaithersburg, MD; Pena, Louis A [Poquott, NY; Lin, Xinhua [Plainview, NY; Takahashi, Kazuyuki [Germantown, MD

    2009-01-27

    Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

  6. Positive modulator of bone morphogenic protein-2

    Energy Technology Data Exchange (ETDEWEB)

    Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua; Kazuyuki, Takahashi

    2017-06-06

    Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

  7. Distal radioulnar joint injuries

    Directory of Open Access Journals (Sweden)

    Binu P Thomas

    2012-01-01

    Full Text Available Distal radioulnar joint is a trochoid joint relatively new in evolution. Along with proximal radioulnar joint , forearm bones and interosseous membrane, it allows pronosupination and load transmission across the wrist. Injuries around distal radioulnar joint are not uncommon, and are usually associated with distal radius fractures,fractures of the ulnar styloid and with the eponymous Galeazzi or Essex_Lopresti fractures. The injury can be purely involving the soft tissue especially the triangular fibrocartilage or the radioulnar ligaments.The patients usually present with ulnar sided wrist pain, features of instability, or restriction of rotation. Difficulty in carrying loads in the hand is a major constraint for these patients. Thorough clinical examination to localize point of tenderness and appropriate provocative tests help in diagnosis. Radiology and MRI are extremely useful, while arthroscopy is the gold standard for evaluation. The treatment protocols are continuously evolving and range from conservative, arthroscopic to open surgical methods. Isolated dislocation are uncommon. Basal fractures of the ulnar styloid tend to make the joint unstable and may require operative intervention. Chronic instability requires reconstruction of the stabilizing ligaments to avoid onset of arthritis. Prosthetic replacement in arthritis is gaining acceptance in the management of arthritis.

  8. Stiffness of the ligaments of the human wrist joint

    NARCIS (Netherlands)

    Savelberg, H.H.C.M.; Kooloos, J.G.M.; Huiskes, H.W.J.; Kauer, J.M.G.

    1992-01-01

    The stiffnesses of the superficial ligaments of 14 human cadaver wrist joints have been determined. In these experiments the tested, fresh-frozen carpal joints are divided into a number of bone-ligament-bone complexes, which are loaded in a tensile testing machine at a rate of 66% of the ligaments'

  9. Early Diagnosis of Avascular Necrosis of Bone Following Renal Transplantation By Bone Scan

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hyun Ho; Kim, Han Su; Ihn, Chun Gyoo; Kim, Myung Jae [Kyung Hee University College of Medicine, Seoul (Korea, Republic of)

    1982-09-15

    Avascular necrosis of bone has become a well-recognized complication of renal transplantation. While preexisting metabolic bone disease, especially hyperparathyroidism, and metabolic disturbances induced by steroids have been implicated as etiological factors, the pathogenesis is controversial. The diagnosis of avascular necrosis of bone had been based on a history of joint pain and radiographic demonstration of bone necrosis. Recently the bone scan using {sup 99m}Tc-methylene diphosphonate is helpful in determining the early stage of bone necrosis. We report two cases of avascular necrosis of femur head, of which diagnosis was made by the bone scan using {sup 99m}Tc-methylene diphosphonate.

  10. Early Diagnosis of Avascular Necrosis of Bone Following Renal Transplantation By Bone Scan

    International Nuclear Information System (INIS)

    Shin, Hyun Ho; Kim, Han Su; Ihn, Chun Gyoo; Kim, Myung Jae

    1982-01-01

    Avascular necrosis of bone has become a well-recognized complication of renal transplantation. While preexisting metabolic bone disease, especially hyperparathyroidism, and metabolic disturbances induced by steroids have been implicated as etiological factors, the pathogenesis is controversial. The diagnosis of avascular necrosis of bone had been based on a history of joint pain and radiographic demonstration of bone necrosis. Recently the bone scan using 99m Tc-methylene diphosphonate is helpful in determining the early stage of bone necrosis. We report two cases of avascular necrosis of femur head, of which diagnosis was made by the bone scan using 99m Tc-methylene diphosphonate.

  11. Effect of layout on surge line thermal stratification

    International Nuclear Information System (INIS)

    Lai Jianyong; Huang Wei

    2011-01-01

    In order to analyze and evaluate the effect of layout on the thermal stratification for PWR Pressurizer surge line, numerical simulation by Computational Fluid Dynamics (CFD) method is taken on 6 kinds of layout improvement with 2 improvement schemes, i.e., increasing the obliquity of quasi horizontal section and adding a vertical pipe between the quasi horizontal section and next elbow, and the maximum temperature differences of quasi horizontal section of surge line of various layouts under different flowrate are obtained. The comparison shows that, the increasing of the obliquity of quasi horizontal section can mitigate the thermal stratification phenomena but can not eliminate this phenomena, while the adding of a vertical pipe between the quasi horizontal section and next elbow can effectively mitigate and eliminate the thermal stratification phenomena. (authors)

  12. Thermal stratification and fatigue stress analysis for pressurizer surge line

    International Nuclear Information System (INIS)

    Yu Xiaofei; Zhang Yixiong

    2011-01-01

    Thermal stratification of pressurizer surge line induced by the inside fluid results in the global bending moments, local thermal stresses, unexpected displacements and support loadings of the pipe system. In order to avoid a costly three-dimensional computation, a combined 1D/2D technique has been developed and implemented to analyze the thermal stratification and fatigue stress of pressurize surge line of QINSHAN Phase II Extension Nuclear Power Project in this paper, using the computer codes SYSTUS and ROCOCO. According to the mechanical analysis results of stratification, the maximum stress and cumulative usage factor are obtained. The results indicate that the stress and fatigue intensity considering thermal stratification satisfies RCC-M criterion. (authors)

  13. Use of historical information in extreme storm surges frequency analysis

    Science.gov (United States)

    Hamdi, Yasser; Duluc, Claire-Marie; Deville, Yves; Bardet, Lise; Rebour, Vincent

    2013-04-01

    The prevention of storm surge flood risks is critical for protection and design of coastal facilities to very low probabilities of failure. The effective protection requires the use of a statistical analysis approach having a solid theoretical motivation. Relating extreme storm surges to their frequency of occurrence using probability distributions has been a common issue since 1950s. The engineer needs to determine the storm surge of a given return period, i.e., the storm surge quantile or design storm surge. Traditional methods for determining such a quantile have been generally based on data from the systematic record alone. However, the statistical extrapolation, to estimate storm surges corresponding to high return periods, is seriously contaminated by sampling and model uncertainty if data are available for a relatively limited period. This has motivated the development of approaches to enlarge the sample extreme values beyond the systematic period. The nonsystematic data occurred before the systematic period is called historical information. During the last three decades, the value of using historical information as a nonsystematic data in frequency analysis has been recognized by several authors. The basic hypothesis in statistical modeling of historical information is that a perception threshold exists and that during a giving historical period preceding the period of tide gauging, all exceedances of this threshold have been recorded. Historical information prior to the systematic records may arise from high-sea water marks left by extreme surges on the coastal areas. It can also be retrieved from archives, old books, earliest newspapers, damage reports, unpublished written records and interviews with local residents. A plotting position formula, to compute empirical probabilities based on systematic and historical data, is used in this communication paper. The objective of the present work is to examine the potential gain in estimation accuracy with the

  14. THE METHOD OF KNEE JOINT ARTHRODESIS

    Directory of Open Access Journals (Sweden)

    V. G. Fedorov

    2011-01-01

    Full Text Available The usage of bone plastics by cylindrical autotransplant in cases of posttraumatic changes of knee joint is described. Knee joint arthrodesis is supposed to be used as alternate in term of replacement impossibility (for example, high-grade deformity, the age (osteoporosis, concomitant diseases that can lead to complicate operation.

  15. Vitamin K, osteoarthritis, and joint pain

    Science.gov (United States)

    Osteoarthritis is the leading cause of joint pain and lower extremity disability in older adults and there is no known cure. Vitamin K has been implicated on osteoarthritis because vitamin K dependent proteins are present in joint tissues, such as cartilage and bone. In order to function, vitamin K ...

  16. An Osteoinductive Polymer Composite for Cranial and Maxillofacial Bone Repair,

    Science.gov (United States)

    1985-01-01

    a suitable level of anesthesia , a semi-lunar incision was made in the midline from the superior sagittal crest to the middle of the nasal bone. The...internal fixation of Fractures, and as intraosseous bone repair materials. A promising use for these polymers has been as carriers for osteogenic...acids. Oral Surg. 37:142, 1974. 7. Getter, L., Cutright, D.E., Bhaskar, S.N., and Augsburg, J.K. A biodegradable intraosseous apliance in the

  17. The destruction influence of pulse and surge currents on overvoltage protection

    International Nuclear Information System (INIS)

    Glasa, M.; Huettner, L.

    2012-01-01

    This article deals about the influences caused during the active operation process of the surge arrester against the pulse and surge currents. It also refers about a lightning, the characteristic of lightning and about the lightning (surge) currents caused its influence. One parts of the article is focused on a total elimination of surge current energy, and on an ineffective operation, which leads to partially or totally destruction of a protection element. There is a comparison with two basic types of surge arresters (spark gap and varistor based arresters), and theirs re-effectiveness on prescribed level. (Authors)

  18. Assessing and Mitigating Hurricane Storm Surge Risk in a Changing Environment

    Science.gov (United States)

    Lin, N.; Shullman, E.; Xian, S.; Feng, K.

    2017-12-01

    Hurricanes have induced devastating storm surge flooding worldwide. The impacts of these storms may worsen in the coming decades because of rapid coastal development coupled with sea-level rise and possibly increasing storm activity due to climate change. Major advances in coastal flood risk management are urgently needed. We present an integrated dynamic risk analysis for flooding task (iDraft) framework to assess and manage coastal flood risk at the city or regional scale, considering integrated dynamic effects of storm climatology change, sea-level rise, and coastal development. We apply the framework to New York City. First, we combine climate-model projected storm surge climatology and sea-level rise with engineering- and social/economic-model projected coastal exposure and vulnerability to estimate the flood damage risk for the city over the 21st century. We derive temporally-varying risk measures such as the annual expected damage as well as temporally-integrated measures such as the present value of future losses. We also examine the individual and joint contributions to the changing risk of the three dynamic factors (i.e., sea-level rise, storm change, and coastal development). Then, we perform probabilistic cost-benefit analysis for various coastal flood risk mitigation strategies for the city. Specifically, we evaluate previously proposed mitigation measures, including elevating houses on the floodplain and constructing flood barriers at the coast, by comparing their estimated cost and probability distribution of the benefit (i.e., present value of avoided future losses). We also propose new design strategies, including optimal design (e.g., optimal house elevation) and adaptive design (e.g., flood protection levels that are designed to be modified over time in a dynamic and uncertain environment).

  19. Hospitals Capability in Response to Disasters Considering Surge Capacity Approach

    Directory of Open Access Journals (Sweden)

    Gholamreza Khademipour

    2016-01-01

    Full Text Available Background: The man-made and natural disasters have adverse effects with sound, apparent, and unknown consequences. Among various components of disaster management in health sector, the most important role is performed by health-treatment systems, especially hospitals. Therefore, the present study aimed to evaluate the surge capacity of hospitals of Kerman Province in disaster in 2015. Materials and Methods: This is a quantitative study, conducted on private, military, and medical sciences hospitals of Kerman Province. The sampling method was total count and data collection for the research was done by questionnaire. The first section of the questionnaire included demographic information of the studied hospitals and second part examined the hospital capacity in response to disasters in 4 fields of equipment, physical space, human resources, and applied programs. The extracted data were analyzed by descriptive statistics. Results: The mean capability of implementing the surge capacity programs by hospitals of Kerman Province in disasters and in 4 fields of equipment, physical space, human resources, and applied programs was evaluated as 7.33% (weak. The surge capacity capability of state hospitals in disasters was computed as 8% and compared to private hospitals (6.07% had a more suitable condition. Conclusion: Based on the results of study and significance of preparedness of hospitals in response to disasters, it is proposed that managers of studied hospitals take measures to promote the hospital response capacity to disasters based on 4 components of increasing hospital capacity.

  20. Bone Cancer

    Science.gov (United States)

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  1. Bone Diseases

    Science.gov (United States)

    Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly ... childhood and your teens, your body adds new bone faster than it removes old bone. After about ...

  2. Joint Projections of US East Coast Sea Level and Storm Surge

    Science.gov (United States)

    Little, Christopher M.; Horton, Radley M.; Kopp, Robert E.; Oppenheimer, Michael; Vecchi, Gabriel A.; Villarini, Gabriele

    2015-01-01

    Future coastal flood risk will be strongly influenced by sea-level rise (SLR) and changes in the frequency and intensity of tropical cyclones. These two factors are generally considered independently. Here, we assess twenty-first century changes in the coastal hazard for the US East Coast using a flood index (FI) that accounts for changes in flood duration and magnitude driven by SLR and changes in power dissipation index (PDI, an integrated measure of tropical cyclone intensity, frequency and duration). Sea-level rise and PDI are derived from representative concentration pathway (RCP) simulations of 15 atmosphere- ocean general circulation models (AOGCMs). By 2080-2099, projected changes in the FI relative to 1986-2005 are substantial and positively skewed: a 10th-90th percentile range 4-75 times higher for RCP 2.6 and 35-350 times higher for RCP 8.5. High-end Fl projections are driven by three AOGCMs that project the largest increases in SLR, PDI and upper ocean temperatures. Changes in PDI are particularly influential if their intra-model correlation with SLR is included, increasing the RCP 8.5 90th percentile FI by a further 25%. Sea-level rise from other, possibly correlated, climate processes (for example, ice sheet and glacier mass changes) will further increase coastal flood risk and should be accounted for in comprehensive assessments.

  3. Gut microbiome and bone.

    Science.gov (United States)

    Ibáñez, Lidia; Rouleau, Matthieu; Wakkach, Abdelilah; Blin-Wakkach, Claudine

    2018-04-11

    The gut microbiome is now viewed as a tissue that interacts bidirectionally with the gastrointestinal, immune, endocrine and nervous systems, affecting the cellular responses in numerous organs. Evidence is accumulating of gut microbiome involvement in a growing number of pathophysiological processes, many of which are linked to inflammatory responses. More specifically, data acquired over the last decade point to effects of the gut microbiome on bone mass regulation and on the development of bone diseases (such as osteoporosis) and of inflammatory joint diseases characterized by bone loss. Mice lacking a gut microbiome have bone mass alteration that can be reversed by gut recolonization. Changes in the gut microbiome composition have been reported in mice with estrogen-deficiency osteoporosis and have also been found in a few studies in humans. Probiotic therapy decreases bone loss in estrogen-deficient animals. The effect of the gut microbiome on bone tissue involves complex mechanisms including modulation of CD4 + T cell activation, control of osteoclastogenic cytokine production and modifications in hormone levels. This complexity may contribute to explain the discrepancies observed betwwen some studies whose results vary depending on the age, gender, genetic background and treatment duration. Further elucidation of the mechanisms involved is needed. However, the available data hold promise that gut microbiome manipulation may prove of interest in the management of bone diseases. Copyright © 2018 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.

  4. [Subchondral bone in osteoarthritis: a review].

    Science.gov (United States)

    Pang, Jian; Cao, Yue-long; Shi, Yin-yu

    2011-08-01

    Osteoarthritis (OA) is the most prevalent of joint diseases,and its pathology is characterized by the degeneration of cartilage, sclerosis of subchondral bone, and osteophyte formation. Localization of the early lesions of OA has not been clarified, but many researchers have focused on cartilage and have considered that changes in subchondral bone occur subsequently to the degeneration of cartilage. However, a low bone mineral density, particularly in the knee joint with OA, high bone turnover, and efficacy of bone resorption inhibitors for OA have recently been reported, suggesting that subchondral bone plays an important role in the pathogenesis of OA. This review aims to make a conclusion about advancement in research of subchondral bone in osteoarthritis.

  5. Temporomandibular joint

    International Nuclear Information System (INIS)

    Westesson, P.L.; Hatala, M.; Tallents, R.H.; Katzberg, R.W.; Musgrave, M.; Levitt, S.

    1990-01-01

    This paper determines the frequency of MR signs of abnormal temporomandibular joints (TMJs) in asymptomatic volunteers. Forty-two volunteers with 84 clinically normal TMJs were imaged in the sagittal and coronal planes with surface coil MR imaging. Sagittal closed and open and coronal closed views were obtained bilaterally in all volunteers. The images were classified as normal (superior disk position) or abnormal (disk displacement of degenerative joint disease). Eighteen joints in 11 volunteers were abnormal; 12 had disk displacement with reduction and six had disk displacement without reduction, with associated degenerative joint disease in three of the six. Asymptomatic internal derangement and degenerative joint disease occur in about one-fourth of asymptomatic volunteers

  6. [The injection of acrylic bone cement prevents bone collapse in the intercalar bones lacking bony support: an experimental sheep semilunar bone model].

    Science.gov (United States)

    Unsal, Murat; Tetik, Cihangir; Erol, Bülent; Cabukoğlu, Cengiz

    2003-01-01

    In a sheep semilunar bone model, we investigated whether collapse in the intercalar bones lacking bony support could be prevented by the injection of acrylic bone cement. The study included 16 limbs of eight sheep. Preoperatively, anteroposterior and lateral views of the carpal joints in the fore limbs were obtained. The animals were divided into four groups. In group 1 (n=3) no surgical procedure was performed in the right semilunar bones, whereas the periosteum on the contralateral side was elevated (group 2; n=3). The first two groups were left as controls. In Group 3 (n=5) the left semilunar bones were filled with acrylic bone cement following decancellation of the bone, while the right semilunar bones were left decancellated (group 4; n=5). The sheep were monitored for three months. Radiographs of the carpal joints were obtained to evaluate collapse occurrence in the semilunar bones. Thereafter, the animals were sacrificed and the semilunar bones were excised for biomechanical and histological examinations. Osteonecrosis and cartilage damage were sought and resistance to compressive forces was investigated. Radiologically, the extent of collapse was statistically significant in the semilunar bones in group 4 (pbone cement was found to prevent collapse in group 3, with no significant difference being noted between preoperative and postoperative semilunar bone heights (p>0.05). Biomechanically, the least resistance to compressive forces was measured in group 4 (pbone cement prevents collapse in the semilunar bones, without inducing any cartilage damage or osteonecrosis.

  7. Degenerative Joint Diseases and Neuroinflammation.

    Science.gov (United States)

    Fusco, Mariella; Skaper, Stephen D; Coaccioli, Stefano; Varrassi, Giustino; Paladini, Antonella

    2017-04-01

    Rheumatic and joint diseases, as exemplified by osteoarthritis and rheumatoid arthritis, are among the most widespread painful and disabling pathologies across the globe. Given the continuing rise in life expectancy, their prevalence is destined to grow. Osteoarthritis, a degenerative joint disease, is, in particular, on its way to becoming the fourth leading cause of disability worldwide by 2020, with the rising incidence of obesity in addition to age being important factors. It is estimated that 25% of osteoarthritic individuals are unable to perform daily activities. Accompanying osteoarthritis is rheumatoid arthritis, which is a chronic systemic disease that often causes pain and deformity. At least 50% of those affected are unable to remain gainfully employed within 10 years of disease onset. A growing body of evidence now points to inflammation, locally and more systemically, as a promoter of damage to joints and bones, as well as joint-related functional deficits. The pathogenesis underlying joint diseases remains unclear; however, it is currently believed that cross-talk between cartilage and subchondral bone-and loss of balance between these two structures in joint diseases-is a critical element. This view is amplified by the presence of mast cells, whose dysregulation is associated with alterations of junction structures (cartilage, bone, synovia, matrix, nerve endings, and blood vessels). In addition, persistent activation of mast cells facilitates the development of spinal neuroinflammation mediated through their interaction with microglia. Unfortunately, current treatment strategies for rheumatic and articular disease are symptomatic and do little to limit disease progression. Research now should be directed at therapeutic modalities that target osteoarticular structural elements and thereby delaying disease progression and joint replacement. © 2016 World Institute of Pain.

  8. Objective measurement of postocclusion surge during phacoemulsification in human eye-bank eyes.

    Science.gov (United States)

    Georgescu, Dan; Payne, Marielle; Olson, Randall J

    2007-03-01

    To objectively compare the postocclusion vacuum surge among different phacoemulsification machines and devices. Experimental study. Infiniti, Legacy, Millennium, and Sovereign were tested in an eye-bank eye. All the machines were tested with 20-gauge non-ABS tips, 430 mm Hg vacuum pressure, 24 ml/minute aspiration rate, peristaltic pump, and 75 cm bottle height. In addition, Infiniti and Legacy were also tested with 20-gauge bypass tips (ABS), 125 cm bottle height, and 40 ml/minute flow rate. We also tested 19-gauge tips with Infiniti and Sovereign and the venturi pump for Millennium. Significant differences were found between all the machines tested with Millennium peristaltic generating the least and Millennium Venturi the most surge. ABS tips significantly decreased the surge for Legacy but not for Infiniti. Cruise Control (CC) had a significant effect on Sovereign but not on Millennium. Increasing the bottle height decreased surge while increasing the flow increased surge for both Infiniti and Legacy. The 19-gauge tips increased surge for both Infiniti and Sovereign. Surge varied over a range of 40 microm to more than 2 mm. ABS and CC decrease surge, especially when the machine is not functioning near the limits of surge prevention. Certain parameters, such as a 19-gauge tip and high flow, dramatically increased surge, whereas elevating the bottle ameliorates it. Understanding the impact of all these features will help in minimizing the problem.

  9. Risk assessment of storm surge disaster based on numerical models and remote sensing

    Science.gov (United States)

    Liu, Qingrong; Ruan, Chengqing; Zhong, Shan; Li, Jian; Yin, Zhonghui; Lian, Xihu

    2018-06-01

    Storm surge is one of the most serious ocean disasters in the world. Risk assessment of storm surge disaster for coastal areas has important implications for planning economic development and reducing disaster losses. Based on risk assessment theory, this paper uses coastal hydrological observations, a numerical storm surge model and multi-source remote sensing data, proposes methods for valuing hazard and vulnerability for storm surge and builds a storm surge risk assessment model. Storm surges in different recurrence periods are simulated in numerical models and the flooding areas and depth are calculated, which are used for assessing the hazard of storm surge; remote sensing data and GIS technology are used for extraction of coastal key objects and classification of coastal land use are identified, which is used for vulnerability assessment of storm surge disaster. The storm surge risk assessment model is applied for a typical coastal city, and the result shows the reliability and validity of the risk assessment model. The building and application of storm surge risk assessment model provides some basis reference for the city development plan and strengthens disaster prevention and mitigation.

  10. Bone scintigraphy in renal osteopathy

    International Nuclear Information System (INIS)

    Hermann, H.J.; Gahl, G.; Freie Univ. Berlin

    1976-01-01

    25 patients with chronic renal disease are investigated. In 16 cases with conservative treatment the bone scintigram showed pathological uptake according to the creatinine level, mainly in the joints of iliosacrum, hip, knee and ankles. In three patients increased uptake in the skull was found. The bone uptake found by scintigraphy was highly pronounced in the patients treated by dialysis. The most frequently involved regions were the joints of iliocacrum and hip, facial cranium, skull, pelvis and metatarsus. The count-rate ratio of cranium to chest was significantly increased in 6 patients. The investigations 6 months later showed in 4 cases a further increase compared with the first values. Count-rates of the skull were found to be comparable to the highly increased uptake in Paget's disease. Bone scintigraphy is a suitable method to estimate semiquantitatively the bone turnover in renal disease. (orig.) [de

  11. Hybrid vs Adaptive Ensemble Kalman Filtering for Storm Surge Forecasting

    Science.gov (United States)

    Altaf, M. U.; Raboudi, N.; Gharamti, M. E.; Dawson, C.; McCabe, M. F.; Hoteit, I.

    2014-12-01

    Recent storm surge events due to Hurricanes in the Gulf of Mexico have motivated the efforts to accurately forecast water levels. Toward this goal, a parallel architecture has been implemented based on a high resolution storm surge model, ADCIRC. However the accuracy of the model notably depends on the quality and the recentness of the input data (mainly winds and bathymetry), model parameters (e.g. wind and bottom drag coefficients), and the resolution of the model grid. Given all these uncertainties in the system, the challenge is to build an efficient prediction system capable of providing accurate forecasts enough ahead of time for the authorities to evacuate the areas at risk. We have developed an ensemble-based data assimilation system to frequently assimilate available data into the ADCIRC model in order to improve the accuracy of the model. In this contribution we study and analyze the performances of different ensemble Kalman filter methodologies for efficient short-range storm surge forecasting, the aim being to produce the most accurate forecasts at the lowest possible computing time. Using Hurricane Ike meteorological data to force the ADCIRC model over a domain including the Gulf of Mexico coastline, we implement and compare the forecasts of the standard EnKF, the hybrid EnKF and an adaptive EnKF. The last two schemes have been introduced as efficient tools for enhancing the behavior of the EnKF when implemented with small ensembles by exploiting information from a static background covariance matrix. Covariance inflation and localization are implemented in all these filters. Our results suggest that both the hybrid and the adaptive approach provide significantly better forecasts than those resulting from the standard EnKF, even when implemented with much smaller ensembles.

  12. High Resolution Hurricane Storm Surge and Inundation Modeling (Invited)

    Science.gov (United States)

    Luettich, R.; Westerink, J. J.

    2010-12-01

    Coastal counties are home to nearly 60% of the U.S. population and industry that accounts for over 16 million jobs and 10% of the U.S. annual gross domestic product. However, these areas are susceptible to some of the most destructive forces in nature, including tsunamis, floods, and severe storm-related hazards. Since 1900, tropical cyclones making landfall on the US Gulf of Mexico Coast have caused more than 9,000 deaths; nearly 2,000 deaths have occurred during the past half century. Tropical cyclone-related adjusted, annualized losses in the US have risen from 1.3 billion from 1949-1989, to 10.1 billion from 1990-1995, and $35.8 billion per year for the period 2001-2005. The risk associated with living and doing business in the coastal areas that are most susceptible to tropical cyclones is exacerbated by rising sea level and changes in the characteristics of severe storms associated with global climate change. In the five years since hurricane Katrina devastated the northern Gulf of Mexico Coast, considerable progress has been made in the development and utilization of high resolution coupled storm surge and wave models. Recent progress will be presented with the ADCIRC + SWAN storm surge and wave models. These tightly coupled models use a common unstructured grid in the horizontal that is capable of covering large areas while also providing high resolution (i.e., base resolution down to 20m plus smaller subgrid scale features such as sea walls and levees) in areas that are subject to surge and inundation. Hydrodynamic friction and overland winds are adjusted to account for local land cover. The models scale extremely well on modern high performance computers allowing rapid turnaround on large numbers of compute cores. The models have been adopted for FEMA National Flood Insurance Program studies, hurricane protection system design and risk analysis, and quasi-operational forecast systems for several regions of the country. They are also being evaluated as

  13. Coastal Flooding Hazards due to storm surges and subsidence

    DEFF Research Database (Denmark)

    Sørensen, Carlo; Knudsen, Per; Andersen, Ole B.

    Flooding hazard and risk mapping are major topics in low-lying coastal areas before even considering the adverse effects of sea level rise (SLR) due to climate change. While permanent inundation may be a prevalent issue, more often floods related to extreme events (storm surges) have the largest...... damage potential.Challenges are amplified in some areas due to subsidence from natural and/or anthropogenic causes. Subsidence of even a few mm/y may over time greatly impair the safety against flooding of coastal communities and must be accounted for in order to accomplish the economically most viable...

  14. Vulnerability of Coastal Communities from Storm Surge and Flood Disasters

    Science.gov (United States)

    Bathi, Jejal Reddy; Das, Himangshu S.

    2016-01-01

    Disasters in the form of coastal storms and hurricanes can be very destructive. Preparing for anticipated effects of such disasters can help reduce the public health and economic burden. Identifying vulnerable population groups can help prioritize resources for the most needed communities. This paper presents a quantitative framework for vulnerability measurement that incorporates both socioeconomic and flood inundation vulnerability. The approach is demonstrated for three coastal communities in Mississippi with census tracts being the study unit. The vulnerability results are illustrated as thematic maps for easy usage by planners and emergency responders to assist in prioritizing their actions to vulnerable populations during storm surge and flood disasters. PMID:26907313

  15. MRI of the hip joint

    International Nuclear Information System (INIS)

    Czerny, C.; Noebauer-Huhmann, I.M.; Imhof, H.

    2005-01-01

    Magnetic resonance imaging (MRI) is performed to diagnose many pathologic conditions affecting the hip joint. Either conventional MRI (without contrast enhancement of the joint cavity) or MR arthrography is used to detect and most accurately differentiate hip joint pathologies. Conventional MRI is performed in cases of bone marrow edema, necrosis, arthrosis and especially the so-called ''activated arthrosis'', as well as in inflammatory and tumorous entities. MR arthography, which has only recently become available for use, is excellently suited for diagnosing lesions of the acetabular labrum, cartilage lesions, and free articular bodies. This article provides an overview about MRI characteristics and their accuracy of hip joint diseases and the impact on the therapeutic procedure. (orig.)

  16. Multidecadal Scale Detection Time for Potentially Increasing Atlantic Storm Surges in a Warming Climate

    Science.gov (United States)

    Lee, Benjamin Seiyon; Haran, Murali; Keller, Klaus

    2017-10-01

    Storm surges are key drivers of coastal flooding, which generate considerable risks. Strategies to manage these risks can hinge on the ability to (i) project the return periods of extreme storm surges and (ii) detect potential changes in their statistical properties. There are several lines of evidence linking rising global average temperatures and increasingly frequent extreme storm surges. This conclusion is, however, subject to considerable structural uncertainty. This leads to two main questions: What are projections under various plausible statistical models? How long would it take to distinguish among these plausible statistical models? We address these questions by analyzing observed and simulated storm surge data. We find that (1) there is a positive correlation between global mean temperature rise and increasing frequencies of extreme storm surges; (2) there is considerable uncertainty underlying the strength of this relationship; and (3) if the frequency of storm surges is increasing, this increase can be detected within a multidecadal timescale (≈20 years from now).

  17. Bone marrow edema in sports: General concepts

    International Nuclear Information System (INIS)

    Vanhoenacker, F.M.; Snoeckx, A.

    2007-01-01

    This paper will discuss the value of medical imaging in the detection and follow-up of bone marrow edema (BME), resulting from acute and chronic trauma in sports. MR imaging is the only imaging technique that allows direct evaluation of bone marrow edema in sports medicine. The use of fat suppressed T2-weighted or STIR images is particularly appropriate to detect bone marrow edema. The extent of bone marrow edema reflects the biomechanics of trauma. Compressive forces between two bony structures will result in extensive areas of bone marrow edema, whereas distraction forces provoke more subtle areas of bone marrow edema at the insertion of supporting structures of joints. In most clinical situations, a combination of compression and distraction forces is present, causing a complex pattern of bone marrow edema. A meticulous pattern approach of the distribution of these bone marrow changes around a joint can reveal in most instances the underlying mechanism of trauma. This may be helpful to analyze which joint supporting structures may be at risk. In the acute setting, plain radiography and CT scan may have an additional role in the detection of small avulsion fractures occurring at the site of minor areas of bone marrow edema. The clinical significance and natural history of bone marrow edema is still a matter of debate

  18. Bone scintigraphy in psoriasis

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, K.; Thiers, G.; Eissner, D.; Holzmann, H.

    1980-08-01

    Since 1973 bone scintigraphy using sup(99m)Tc-phosphate-complexes was carried out in 382 patients with psoriasis. For comparison with the results of nuclear medicine, roentgenologic and clinical findings a group af 121 patients with psoriasis aged between 11 and 74 years was compared to a group of 42 patients aged between 20 and 49 years without roentgenologic and clinical signs of psoriasis arthritis. We found by means of isotope investigation that an essentially greater part of the bones adjacent to the joints was involved than was expected according to X-ray and clinical findings. In addition, in 205 patients with psoriasis whole-body scintigraphy, using sup(99m)Tc-MDP, was carried out since 1977/78. In 17 patients we found an increased accumulation of activity in the region of extraarticular structures of the skull as well as of the skeletal thorax. According to these results we conclude that in addition to the clinically and roentgenologically defined psoriatic arthritis in patients with psoriasis an osteopathy may exist, which can only be demonstrated by skeletal scintigraphy and which is localized in bones adjacent to the joints but can also be demonstrated in the region of extraarticular bones.

  19. Bone scintigraphy in psoriasis

    International Nuclear Information System (INIS)

    Hahn, K.; Thiers, G.; Eissner, D.; Holzmann, H.; Frankfurt Univ.

    1980-01-01

    Since 1973 bone scintigraphy using sup(99m)Tc-phosphate-complexes was carried out in 382 patients with psoriasis. For comparison with the results of nuclear medicine, roentgenologic and clinical findings a group af 121 patients with psoriasis aged between 11 and 74 years was compared to a group of 42 patients aged between 20 and 49 years without roentgenologic and clinical signs of psoriasis arthritis. We found by means of isotope investigation that an essentially greater part of the bones adjacent to the joints was involved than was expected according to X-ray and clinical findings. In addition, in 205 patients with psoriasis whole-body scintigraphy, using sup(99m)Tc-MDP, was carried out since 1977/78. In 17 patients we found an increased accumulation of activity in the region of extraarticular structures of the skull as well as of the skeletal thorax. According to these results we conclude that in addition to the clinically and roentgenologically defined psoriatic arthritis in patients with psoriasis an osteopathy may exist, which can only be demonstrated by skeletal scintigraphy and which is localized in bones adjacent to the joints but can also be demonstrated in the region of extraarticular bones. (orig.) [de

  20. Joint pain

    Science.gov (United States)

    ... or conditions. It may be linked to arthritis , bursitis , and muscle pain . No matter what causes it, ... Autoimmune diseases such as rheumatoid arthritis and lupus Bursitis Chondromalacia patellae Crystals in the joint: Gout (especially ...

  1. Joint Commission

    Science.gov (United States)

    ... for the latest publication of The Joint Commission Journal on Quality and Patient Safety (JQPS). . How We Work Process improvement program breeds quality culture, empowers staff An article in Quality Progress, June ...

  2. The Use of a Statistical Model of Storm Surge as a Bias Correction for Dynamical Surge Models and its Applicability along the U.S. East Coast

    Directory of Open Access Journals (Sweden)

    Haydee Salmun

    2015-02-01

    Full Text Available The present study extends the applicability of a statistical model for prediction of storm surge originally developed for The Battery, NY in two ways: I. the statistical model is used as a biascorrection for operationally produced dynamical surge forecasts, and II. the statistical model is applied to the region of the east coast of the U.S. susceptible to winter extratropical storms. The statistical prediction is based on a regression relation between the “storm maximum” storm surge and the storm composite significant wave height predicted ata nearby location. The use of the statistical surge prediction as an alternative bias correction for the National Oceanic and Atmospheric Administration (NOAA operational storm surge forecasts is shownhere to be statistically equivalent to the existing bias correctiontechnique and potentially applicable for much longer forecast lead times as well as for storm surge climate prediction. Applying the statistical model to locations along the east coast shows that the regression relation can be “trained” with data from tide gauge measurements and near-shore buoys along the coast from North Carolina to Maine, and that it provides accurate estimates of storm surge.

  3. Bone marrow aspiration

    Science.gov (United States)

    Iliac crest tap; Sternal tap; Leukemia - bone marrow aspiration; Aplastic anemia - bone marrow aspiration; Myelodysplastic syndrome - bone marrow aspiration; Thrombocytopenia - bone marrow aspiration; Myelofibrosis - bone marrow aspiration

  4. Tide-surge interaction along the east coast of the Leizhou Peninsula, South China Sea

    Science.gov (United States)

    Zhang, Heng; Cheng, Weicong; Qiu, Xixi; Feng, Xiangbo; Gong, Wenping

    2017-06-01

    A triply-nested two-dimensional (2D) ocean circulation model along with observed sea level records are used to study tide-surge interaction along the east coast of the Leizhou Peninsula (LP) which is characterized by extensive mudflats, large tidal ranges and a complex coastline. The dependency of surge maxima on the water level and the phase of tide are respectively investigated using two statistical approaches. Results show that tide-surge interaction along the east coast of the LP is significant, where surges peak 3-6 h before or after the nearest high water. The triply-nested 2D ocean circulation model is used to quantify tide-surge interaction in this region and to investigate its physical cause. The largest amplitudes of tide-surge interaction are found in the shallow water region of the Leizhou Bay, with values up to 1 m during typhoon events. Numerical experiments reveal that nonlinear bottom friction is the main contributor to tide-surge interaction, while the contribution of the nonlinear advective effect can be neglected. The shallow water effect enhances the role of nonlinear bottom friction in determining tide-surge modulation, leaving the surge peaks usually occur on the rising or falling tide. It is also found that the relative contribution of local wind and remote wind is different depending on the storm track and storm intensity, which would finally affect the temporal and spatial distribution of tide-surge interaction during typhoon events. These findings confirm the importance of coupling storm surges and tides for the prediction of storm surge events in regions which are characterized by shallow water depths and large tidal ranges.

  5. Characteristics and possibilities of software tool for metal-oxide surge arresters selection

    Directory of Open Access Journals (Sweden)

    Đorđević Dragan

    2012-01-01

    Full Text Available This paper presents a procedure for the selection of metal-oxide surge arresters based on the instructions given in the Siemens and ABB catalogues, respecting their differences and the characteristics and possibilities of the software tool. The software tool was developed during the preparation of a Master's thesis titled, 'Automation of Metal-Oxide Surge Arresters Selection'. An example is presented of the selection of metal-oxide surge arresters using the developed software tool.

  6. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Gesch, Dean B.

    2009-01-01

    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  7. Bones, Muscles, and Joints: The Musculoskeletal System

    Science.gov (United States)

    ... Skeletal muscles are called striated (pronounced: STRY-ay-ted) because they are made up of fibers that ... blood through your body. When we smile and talk, muscles are helping us communicate, and when we ...

  8. Aging changes in the bones - muscles - joints

    Science.gov (United States)

    ... the 40s in women. Lipofuscin (an age-related pigment) and fat are deposited in muscle tissue. The ... changes in body shape Aging changes in hormone production Aging changes in organs, tissues, and cells Aging ...

  9. Occupational diseases of skeleton and bone joints

    International Nuclear Information System (INIS)

    Sokolik, L.I.

    1981-01-01

    The essence of roentgeno-morphological features of locomotor system occupational diseases lies in development of dystrophic, degenerative and necrotic processes. Pathological changes take place during vibration, recoil and strain as well as under the effect of unfavourable microclimate (high humidity, cold), vibration being the most important as compared to other harmful factors. Detailed sanitary-and-hygienic and labour characteristics of working conditions of personnel, subjected to the effect of those factors as well as roentgenological characteristics of locomotor system occupational changes are given [ru

  10. A Comparison of Ensemble Kalman Filters for Storm Surge Assimilation

    KAUST Repository

    Altaf, Muhammad

    2014-08-01

    This study evaluates and compares the performances of several variants of the popular ensembleKalman filter for the assimilation of storm surge data with the advanced circulation (ADCIRC) model. Using meteorological data from Hurricane Ike to force the ADCIRC model on a domain including the Gulf ofMexico coastline, the authors implement and compare the standard stochastic ensembleKalman filter (EnKF) and three deterministic square root EnKFs: the singular evolutive interpolated Kalman (SEIK) filter, the ensemble transform Kalman filter (ETKF), and the ensemble adjustment Kalman filter (EAKF). Covariance inflation and localization are implemented in all of these filters. The results from twin experiments suggest that the square root ensemble filters could lead to very comparable performances with appropriate tuning of inflation and localization, suggesting that practical implementation details are at least as important as the choice of the square root ensemble filter itself. These filters also perform reasonably well with a relatively small ensemble size, whereas the stochastic EnKF requires larger ensemble sizes to provide similar accuracy for forecasts of storm surge.

  11. A Comparison of Ensemble Kalman Filters for Storm Surge Assimilation

    KAUST Repository

    Altaf, Muhammad; Butler, T.; Mayo, T.; Luo, X.; Dawson, C.; Heemink, A. W.; Hoteit, Ibrahim

    2014-01-01

    This study evaluates and compares the performances of several variants of the popular ensembleKalman filter for the assimilation of storm surge data with the advanced circulation (ADCIRC) model. Using meteorological data from Hurricane Ike to force the ADCIRC model on a domain including the Gulf ofMexico coastline, the authors implement and compare the standard stochastic ensembleKalman filter (EnKF) and three deterministic square root EnKFs: the singular evolutive interpolated Kalman (SEIK) filter, the ensemble transform Kalman filter (ETKF), and the ensemble adjustment Kalman filter (EAKF). Covariance inflation and localization are implemented in all of these filters. The results from twin experiments suggest that the square root ensemble filters could lead to very comparable performances with appropriate tuning of inflation and localization, suggesting that practical implementation details are at least as important as the choice of the square root ensemble filter itself. These filters also perform reasonably well with a relatively small ensemble size, whereas the stochastic EnKF requires larger ensemble sizes to provide similar accuracy for forecasts of storm surge.

  12. New technology and tool prepared for communication against storm surges.

    Science.gov (United States)

    Letkiewicz, Beata

    2010-05-01

    The aim of the presentation is description of the new technology and tool prepared for communication, information and issue of warnings against storm surges. The Maritime Branch of the Institute of Meteorology and Water Management is responsible for preparing the forecast as warning, where the end users are Government Officials and Public. The Maritime Branch carry out the project "Strengthening the administrative capacity in order to improve the management of Polish coastal zone environment" (supported by a grant from Norway through the Norwegian Financial Mechanism). The expected final result of the project is web site www.baltyk.pogodynka.pl. One of the activities of the project is - set up of information website www.baltyk.pogodynka.pl, giving public access to the complied data. Information on web site: - meta data - marine data (on-line measurement: sea level, water temperature, salinity, oxygen concentration); - data bases of mathematical model outputs - forecast data (sea level, currents); - ice conditions of the Baltic Sea, - instructions, information materials with information of polish coastal zone. The aim of set up of the portal is development of communication between users of the system, exchange of the knowledge of marine environment and natural hazards such as storm surges, improving the ability of the region in the scope of the data management about the sea environment and the coastal zone.

  13. Influence of a Storm Surge Barrier’s Operation on the Flood Frequency in the Rhine Delta Area

    Directory of Open Access Journals (Sweden)

    Hua Zhong

    2012-05-01

    Full Text Available The Rhine River Delta is crucial to the Dutch economy. The Maeslant barrier was built in 1997 to protect the Rhine estuary, with the city and port of Rotterdam, from storm surges. This research takes a simple approach to quantify the influence of the Maeslant storm surge barrier on design water levels behind the barrier. The dikes in the area are supposed to be able to withstand these levels. Equal Level Curves approach is used to calculate the Rotterdam water levels by using Rhine discharges and sea water levels as input. Their joint probability function generates the occurrence frequency of a certain combination that will lead to a certain high water level in Rotterdam. The results show that the flood frequency in Rotterdam is reduced effectively with the controlled barrier in current and in future scenarios influenced by climate change. In addition, an investigation of the sensitivity of the operational parameters suggests that there is a negligible influence on the high water level frequency when the decision closing water level for the barrier is set higher due to the benefits of navigation (but not exceeding the design safety level 4 m MSL.

  14. SURGTANK, Steam Pressure, Saturation Temperature or Reactor Surge Tank

    International Nuclear Information System (INIS)

    Gorman, D.J.; Gupta, R.K.

    2001-01-01

    1 - Description of problem or function: SURGTANK generates the steam pressure, saturation temperature, and ambient temperature history for a nuclear reactor steam surge tank (pressurizer) in a state of thermodynamic equilibrium subjected to a liquid insurge described by a specified time history of liquid levels. It is capable also of providing the pressure and saturation temperature history, starting from thermodynamic equilibrium conditions, for the same tank subjected to an out-surge described by a time history of liquid levels. Both operations are available for light- or heavy- water nuclear reactor systems. The tank is assumed to have perfect thermal insulation on its outer wall surfaces. 2 - Method of solution: Surge tank geometry and initial liquid level and saturation pressure are provided as input for the out-surge problem, along with the prescribed time-sequence level history. SURGTANK assumes a reduced pressure for the end of the first change in liquid level and determines the associated change of entropy for the closed system. The assumed pressure is adjusted and the associated change in entropy recalculated until a pressure is attained for which no change occurs. This pressure is recorded and used as the beginning pressure for the next level increment. The system is then re-defined to exclude the small amount of liquid which has left the tank, and a solution for the pressure at the end of the second level increment is obtained. The procedure is terminated when the pressure at the end of the final increment has been determined. Surge tank geometry, thermal conductivity, specific heat, and density of tank walls, initial liquid level, and saturation pressure are provided as input for the insurge problem, along with the prescribed time-sequence level history. SURGTANK assumes a slightly in- creased pressure for the end of the first level, the inner tank sur- face is assumed to follow saturation temperature, linearly with time, throughout the interval, and

  15. Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

    Science.gov (United States)

    Shi, Xiaoxia; Xu, Tongbin; Yin, Kedong

    2018-01-01

    Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM) model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation. PMID:29584628

  16. Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups.

    Science.gov (United States)

    Jin, Xue; Shi, Xiaoxia; Gao, Jintian; Xu, Tongbin; Yin, Kedong

    2018-03-27

    Storm surge has become an important factor restricting the economic and social development of China's coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc.), storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM) model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation.

  17. Using Satellite Altimetry to Calibrate the Simulation of Typhoon Seth Storm Surge off Southeast China

    Directory of Open Access Journals (Sweden)

    Xiaohui Li

    2018-04-01

    Full Text Available Satellite altimeters can capture storm surges generated by typhoons and tropical storms, if the satellite flies over at the right time. In this study, we show TOPEX/Poseidon altimeter-observed storm surge features off Southeast China on 10 October 1994 during Typhoon Seth. We then use a three-dimensional, barotropic, finite-volume community ocean model (FVCOM to simulate storm surges. An innovative aspect is that satellite data are used to calibrate the storm surge model to improve model performance, by adjusting model wind forcing fields (the National Center for Environment Prediction (NCEP reanalysis product in reference to the typhoon best-track data. The calibration reduces the along-track root-mean-square (RMS difference between model and altimetric data from 0.15 to 0.10 m. It also reduces the RMS temporal difference from 0.21 to 0.18 m between the model results and independent tide-gauge data at Xiamen. In particular, the calibrated model produces a peak storm surge of 1.01 m at 6:00 10 October 1994 at Xiamen, agreeing with tide-gauge data; while the peak storm surge with the NCEP forcing is 0.71 m only. We further show that the interaction between storm surges and astronomical tides contributes to the peak storm surge by 34% and that the storm surge propagates southwestward as a coastally-trapped Kelvin wave.

  18. Evaluation of Loss Due to Storm Surge Disasters in China Based on Econometric Model Groups

    Directory of Open Access Journals (Sweden)

    Xue Jin

    2018-03-01

    Full Text Available Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evaluation of the loss due to storm surges. Due to the relative dispersion and poor regularity of the natural property data (login center air pressure, maximum wind speed, maximum storm water, super warning water level, etc., storm surge disaster is divided based on eight kinds of storm surge disaster grade division methods combined with storm surge water, hypervigilance tide level, and disaster loss. The storm surge disaster loss measurement model groups consist of eight equations, and six major modules are constructed: storm surge disaster in agricultural loss, fishery loss, human resource loss, engineering facility loss, living facility loss, and direct economic loss. Finally, the support vector machine (SVM model is used to evaluate the loss and the intra-sample prediction. It is indicated that the equations of the model groups can reflect in detail the relationship between the damage of storm surges and other related variables. Based on a comparison of the original value and the predicted value error, the model groups pass the test, providing scientific support and a decision basis for the early layout of disaster prevention and mitigation.

  19. Vulnerability assessment of storm surges in the coastal area of Guangdong Province

    Directory of Open Access Journals (Sweden)

    K. Li

    2011-07-01

    Full Text Available Being bordered by the South China Sea and with long coastline, the coastal zone of Guangdong Province is often under severe risk of storm surges, as one of a few regions in China which is seriously threatened by storm surges. This article systematically analyzes the vulnerability factors of storm surges in the coastal area of Guangdong (from Yangjing to Shanwei. Five vulnerability assessment indicators of hazard-bearing bodies are proposed, which are social economic index, land use index, eco-environmental index, coastal construction index, and disaster-bearing capability index. Then storm surge vulnerability assessment index system in the coastal area of Guangdong is established. Additionally, the international general mode about coastal vulnerability assessment is improved, and the vulnerability evolution model of storm surges in the coastal area of Guangdong is constructed. Using ArcGIS, the vulnerability zoning map of storm surges in the study region is drawn. Results show that there is the highest degree of storm surge vulnerability in Zhuhai, Panyu, and Taishan; second in Zhongshan, Dongguan, Huiyang, and Haifeng; third in Jiangmen, Shanwei, Yangjiang, and Yangdong; fourth in Baoan, Kaiping, and Enping; and lowest in Guangzhou, Shunde, Shenzhen, and Longgang. This study on the risk of storm surges in these coastal cities can guide the land use of coastal cities in the future, and provide scientific advice for the government to prevent and mitigate the storm surge disasters. It has important theoretical and practical significance.

  20. Structure design of water discharge surge tank of nuclear power plant

    International Nuclear Information System (INIS)

    Wang Fang; Hou Shuqiang

    2015-01-01

    Drainage is an important function of water discharge surge tank in nuclear power plant. There is little wall and beam inside the water discharge surge tank due to the requirement of major work, which is different from the general structure. Taking water discharge surge tank of nuclear power plant for example, concerned problems are expatiated in the structure scheme of water discharge surge tank, and important structural components are analyzed. Structural analysis model is established by ANSYS finite element analysis. A comprehensive and numerical analysis is performed for different combinations of structural model, and the internal force of structure is extracted. Finally, suggestions for design of similar structure are proposed. (authors)

  1. The Development of Storm Surge Ensemble Prediction System and Case Study of Typhoon Meranti in 2016

    Science.gov (United States)

    Tsai, Y. L.; Wu, T. R.; Terng, C. T.; Chu, C. H.

    2017-12-01

    Taiwan is under the threat of storm surge and associated inundation, which is located at a potentially severe storm generation zone. The use of ensemble prediction can help forecasters to know the characteristic of storm surge under the uncertainty of track and intensity. In addition, it can help the deterministic forecasting. In this study, the kernel of ensemble prediction system is based on COMCOT-SURGE (COrnell Multi-grid COupled Tsunami Model - Storm Surge). COMCOT-SURGE solves nonlinear shallow water equations in Open Ocean and coastal regions with the nested-grid scheme and adopts wet-dry-cell treatment to calculate potential inundation area. In order to consider tide-surge interaction, the global TPXO 7.1 tide model provides the tidal boundary conditions. After a series of validations and case studies, COMCOT-SURGE has become an official operating system of Central Weather Bureau (CWB) in Taiwan. In this study, the strongest typhoon in 2016, Typhoon Meranti, is chosen as a case study. We adopt twenty ensemble members from CWB WRF Ensemble Prediction System (CWB WEPS), which differs from parameters of microphysics, boundary layer, cumulus, and surface. From box-and-whisker results, maximum observed storm surges were located in the interval of the first and third quartile at more than 70 % gauge locations, e.g. Toucheng, Chengkung, and Jiangjyun. In conclusion, the ensemble prediction can effectively help forecasters to predict storm surge especially under the uncertainty of storm track and intensity

  2. Surge protective device response to steep front transient in low voltage circuit

    Energy Technology Data Exchange (ETDEWEB)

    Marcuz, J.; Binczak, S.; Bilbault, J.M. [Universite de Bourgogne, Dijon (France)], Emails: jerome.marcuz@ laposte.net, stbinc@u-bourgogne.fr, bilbault@u-bourgogne.fr; Girard, F. [ADEE Electronic, Pont de Pany (France)

    2007-07-01

    Surge propagation on cables of electrical or data lines leads to a major protection problem as the number of equipment based on solid-state circuits or microprocessors increases. Sub-microsecond components of real surge waveform has to be taken into account for a proper protection even in the case of surges caused by indirect lightning effects. The response of a model of transient voltage suppressor diode based surge protection device (SPD) to fast front transient is analytically studied, then compared to simulations, including the lines connected to the SPD and to the protected equipment. (author)

  3. Low Bone Density

    Science.gov (United States)

    ... Density Exam/Testing › Low Bone Density Low Bone Density Low bone density is when your bone density ... people with normal bone density. Detecting Low Bone Density A bone density test will determine whether you ...

  4. Bone scintigraphy in two cases of chronic brucellosis

    International Nuclear Information System (INIS)

    Kujat, C.; Neidl, K.; Mueller-Leisse, C.; Berg, D.

    1989-01-01

    As shown in the case reports, bone scintigraphy plays an important part considering the diagnosis of chronic brucellosis, an infectious disease which occurs rarely in Germany. To establish the diagnosis knowledge of symptoms and signs of the disease is necessary. Chronic brucellosis may occur in each organ, ionvolving especially bones and joints. The disease may manifest as spondilytis (especially of the lumbar spine) or arthritis of large joints, sacroiliacal joints or costotransverse joints. Chronic brucellosis has to be considered if a bone scan reveals a typical pattern even without a typical history. (orig.) [de

  5. Adaptation of subchondral bone in osteoarthritis

    DEFF Research Database (Denmark)

    Ding, Ming

    2004-01-01

    Osteoarthritis is a chronic joint disease with pathological changes in the articulating cartilage and all other tissues that occupy the joint. Radin and coworkers have suggested the involvement of subchondral bone in the disease process. However, evidence for an essential role in the etiology has...

  6. Joint hypermobility syndrome and related pain

    Directory of Open Access Journals (Sweden)

    Nilay Sahin

    2016-06-01

    Full Text Available Hypermobility is defined as an abnormally increased range of motion of a joint resulting from the excessive laxity of the soft tissues. This paper is focused on this commonly forgotten cause of several morbidities. The etiology of hypermobility is not very well known. One decade ago, joint hypermobility syndrome was considered as a benign condition, but now it is recognized as a significant contributor to chronic musculoskeletal pain, besides impacting on other organs. Patients with joint hypermobility syndrome often have diffuse, chronic complaints that are inconsistent with the musculoskeletal system. Chronic pain may cause loss of proprioception and so increased sensitivity to microtrauma, premature osteoarthritis de- velopment, soft tissue problems, psychosocial disorders, and neurophysiological deficiencies. Osteoarthritis, pes planus, mechanical low back pain, and soft tissue rheumatisms are frequent musculoskeletal findings as well as subluxations, thoracic outlet syndrome, rectal and uterine prolapses, hernias, and stress incontinence. Joint hypermobility syndrome's treatment is not easy, and nonsteroidal anti-inflammatory drugs are not usually effective or adequate. Proprioceptive and strengthening exercises have been reported to have supportive and therapeutic effects, but we have limited data on this issue. Joint hypermobility syndrome must be accepted as a multisystem connective tissue disorder rather than just joint laxities. As a result; clinicians must be aware of complexities of connective tissue disorders and comorbidities. [Arch Clin Exp Surg 2016; 5(2.000: 105-112

  7. The warm sacroiliac joint. A finding in pelvic abscess

    International Nuclear Information System (INIS)

    Slavin, J.D. Jr.; Epstein, N.; Negrin, J.A.; Spencer, R.P.

    1990-01-01

    Two patients with pain referable to the low back and sacroiliac regions had bone scans with similar findings. In each, one sacroiliac joint was warm (uptake on that side was slightly greater than that in the contralateral area). Ga-67 imaging also demonstrated increased uptake in the same locale. Subsequent CT scanning revealed pelvic abscesses adjacent to the affected joints. Asymmetric uptake of bone imaging agent may have been related to hyperemia and heating of the sacroiliac joint. Rapid defervescence with antibiotics and drainage (and no CT evidence of bone involvement) suggested that osteomyelitis was not involved in these cases

  8. The septic versus nonseptic inflamed joint: MRI characteristics

    International Nuclear Information System (INIS)

    Graif, M.; Schweitzer, M.E.; Deely, D.; Matteucci, T.

    1999-01-01

    Objective. To differentiate the MR features of septic versus nonseptic inflamed joints.Design and patients. Thirty patients were referred for MRI with inflamed joints (19 were subsequently found to be septic and 11 nonseptic). At 1.5 T enhanced MRI five groups of signs related to joint space, synovium, cartilage, bone and peri-articular soft tissue respectively were assessed and compared between the septic and nonseptic groups.Results. The prevalence of MRI findings in septic versus nonseptic joints (respectively) was as follows: effusion (79% vs 82%), fluid outpouching (79% vs 73%), fluid heterogeneity (21% vs 27%), synovial thickening (68% vs 55%), synovial periedema (63% vs 55%), synovial enhancement (94% vs 88%), cartilage loss (53% vs 30%), bone erosions (79% vs 38%), bone erosions enhancement (77% vs 43%), bone marrow edema (74% vs 38%), bone marrow enhancement (67% vs 50%), soft tissue edema (63% vs 78%), soft tissue enhancement (67% vs 71%), periosteal edema (11% vs. 10%). The presence of bone erosions appeared to be an indicator for an infected joint (P=0.072); coexistence of bone marrow edema slightly improves the significance (0.068). A similar trend was obtained when combining bone erosions with either synovial thickening, synovial periedema, bone marrow enhancement or soft tissue edema (P=0.075).Conclusions. The combination of bone erosions with marrow edema is highly suggestive for a septic articulation; the additional coexistence of synovial thickening, synovial edema, soft tissue edema or bone marrow enhancement increases the above level of confidence. Similar to conventional radiography, the single sign that appeared to show a significant trend was the presence of bone erosions. However, no single sign or combination could either be considered pathognomonic or exclude the presence of a joint infection. (orig.)

  9. Bone Disease in Axial Spondyloarthritis.

    Science.gov (United States)

    Van Mechelen, Margot; Gulino, Giulia Rossana; de Vlam, Kurt; Lories, Rik

    2018-05-01

    Axial spondyloarthritis is a chronic inflammatory skeletal disorder with an important burden of disease, affecting the spine and sacroiliac joints and typically presenting in young adults. Ankylosing spondylitis, diagnosed by the presence of structural changes to the skeleton, is the prototype of this disease group. Bone disease in axial spondyloarthritis is a complex phenomenon with the coexistence of bone loss and new bone formation, both contributing to the morbidity of the disease, in addition to pain caused by inflammation. The skeletal structural changes respectively lead to increased fracture risk and to permanent disability caused by ankylosis of the sacroiliac joints and the spine. The mechanism of this new bone formation leading to ankylosis is insufficiently known. The process appears to originate from entheses, specialized structures that provide a transition zone in which tendon and ligaments insert into the underlying bone. Growth factor signaling pathways such as bone morphogenetic proteins, Wnts, and Hedgehogs have been identified as molecular drivers of new bone formation, but the relationship between inflammation and activation of these pathways remains debated. Long-standing control of inflammation appears necessary to avoid ankylosis. Recent evidence and concepts suggest an important role for biomechanical factors in both the onset and progression of the disease. With regard to new bone formation, these processes can be understood as ectopic repair responses secondary to inflammation-induced bone loss and instability. In this review, we discuss the clinical implications of the skeletal changes as well as the underlying molecular mechanisms, the relation between inflammation and new bone formation, and the potential role of biomechanical stress.

  10. Dependence between sea surge, river flow and precipitation in south and west Britain

    Directory of Open Access Journals (Sweden)

    C. Svensson

    2004-01-01

    Full Text Available Estuaries around Great Britain may be at heightened risk of flooding because of the simultaneous occurrence of extreme sea surge and river flow, both of which may be caused by mid-latitude cyclones. A measure especially suited for extremes was employed to estimate dependence between river flow and sea surge. To assist in the interpretation of why flow-surge dependence occurs in some areas and not in others, the dependence between precipitation and surge and between precipitation and river flow was also studied. Case studies of the meteorological situations leading to high surges and/or river flows were also carried out. The present study concerns catchments draining to the south and west coasts of Great Britain. Statistically significant dependence between river flow and daily maximum sea surge may be found at catchments spread along most of this coastline. However, higher dependence is generally found in catchments in hilly areas with a southerly to westerly aspect. Here, precipitation in south-westerly airflow, which is generally the quadrant of prevailing winds, will be enhanced orographically as the first higher ground is encountered. The sloping catchments may respond quickly to the abundant rainfall and the flow peak may arrive in the estuary on the same day as a large sea surge is produced by the winds and low atmospheric pressure associated with the cyclone. There are three regions where flow-surge dependence is strong: the western part of the English south coast, southern Wales and around the Solway Firth. To reduce the influence of tide-surge interaction on the dependence analysis, the dependence between river flow and daily maximum surge occurring at high tide was estimated. The general pattern of areas with higher dependence is similar to that using the daily maximum surge. The dependence between river flow and daily maximum sea surge is often strongest when surge and flow occur on the same day. The west coast from Wales and

  11. Comparison of two recent storm surge events based on results of field surveys

    Science.gov (United States)

    Nakamura, Ryota; Shibayama, Tomoya; Mikami, Takahito; Esteban, Miguel; Takagi, Hiroshi; Maell, Martin; Iwamoto, Takumu

    2017-10-01

    This paper compares two different types of storm surge disaster based on field surveys. Two cases: a severe storm surge flood with its height of over 5 m due to Typhoon Haiyan (2013) in Philippine, and inundation of storm surge around Nemuro city in Hokkaido of Japan with its maximum surge height of 2.8 m caused by extra-tropical cyclone are taken as examples. For the case of the Typhoon Haiyan, buildings located in coastal region were severely affected due to a rapidly increase in ocean surface. The non-engineering buildings were partially or completely destroyed due to their debris transported to an inner bay region. In fact, several previous reports indicated two unique features, bore-like wave and remarkably high speed currents. These characteristics of the storm surge may contribute to a wide-spread corruption for the buildings around the affected region. Furthermore, in the region where the surge height was nearly 3 m, the wooden houses were completely or partially destroyed. On the other hand, in Nemuro city, a degree of suffering in human and facility caused by the storm surge is minor. There was almost no partially destroyed residential houses even though the height of storm surge reached nearly 2.8 m. An observation in the tide station in Nemuro indicated that this was a usual type of storm surge, which showed a gradual increase of sea level height in several hours without possessing the unique characteristics like Typhoon Haiyan. As a result, not only the height of storm surge but also the robustness of the buildings and characteristics of storm surge, such as bore like wave and strong currents, determined the existent of devastation in coastal regions.

  12. Surge of Bering Glacier and Bagley Ice Field: Parameterization of surge characteristics based on automated analysis of crevasse image data and laser altimeter data

    Science.gov (United States)

    Stachura, M.; Herzfeld, U. C.; McDonald, B.; Weltman, A.; Hale, G.; Trantow, T.

    2012-12-01

    The dynamical processes that occur during the surge of a large, complex glacier system are far from being understood. The aim of this paper is to derive a parameterization of surge characteristics that captures the principle processes and can serve as the basis for a dynamic surge model. Innovative mathematical methods are introduced that facilitate derivation of such a parameterization from remote-sensing observations. Methods include automated geostatistical characterization and connectionist-geostatistical classification of dynamic provinces and deformation states, using the vehicle of crevasse patterns. These methods are applied to analyze satellite and airborne image and laser altimeter data collected during the current surge of Bering Glacier and Bagley Ice Field, Alaska.

  13. Pre-swirl mechanism in front of a centrifugal compressor: effects on surge line and on unsteady phenomena in surge area

    Directory of Open Access Journals (Sweden)

    Danlos Amélie

    2017-01-01

    Full Text Available Using a pre-swirl mechanism upstream an impeller of a compressor allows to modify its characteristics curve, while weakly damaging its efficiency. Another consequence of the pre-swirl is to push back the surge line limit and to increase the operation zone towards the low flow rate limits. A centrifugal compressor has been modified in order to add a swirl generator device upstream the impeller. The incidence values of blades can vary from 0° (no pre-swirl to ±90°. The variation of the stator blades incidence has several main consequences: to allow a flow rate adjustment with a good efficiency conservation, to increase the angular velocity with a constant shaft power, to produce a displacement of the surge line limit. In this paper, the results of experimental studies are presented to analyze the surge line and the intensity of unsteady phenomena when the compressor works in its surge area.

  14. Joint Intentionality

    Directory of Open Access Journals (Sweden)

    Koreň Ladislav

    2016-03-01

    Full Text Available According to the shared intentionality hypothesis proposed by Michael Tomasello, two cognitive upgrades – joint and collective intentionality, respectively – make human thinking unique. Joint intentionality, in particular, is a mindset supposed to account for our early, species-specific capacity to participate in collaborative activities involving two (or a few agents. In order to elucidate such activities and their proximate cognitive-motivational mechanism, Tomasello draws on philosophical accounts of shared intentionality. I argue that his deference to such cognitively demanding accounts of shared intentional activities is problematic if his theoretical ambition is in part to show that and how early (prelinguistic and precultural capacities for joint action contribute to the development of higher cognitive capacities.

  15. Bone Cancer: Questions and Answers

    Science.gov (United States)

    ... upper arm ( 1 ). Chondrosarcoma , which begins in cartilaginous tissue. Cartilage pads the ends of bones and lines the joints. Chondrosarcoma occurs most often in the pelvis (located between the hip ... in soft tissue (muscle, fat, fibrous tissue, blood vessels , or other ...

  16. Bone X-Ray (Radiography)

    Medline Plus

    Full Text Available ... x-rays. top of page What does the equipment look like? The equipment typically used for bone x-rays consists of ... and joint abnormalities, such as arthritis. X-ray equipment is relatively inexpensive and widely available in emergency ...

  17. Bone tumors

    International Nuclear Information System (INIS)

    Moylan, D.J.; Yelovich, R.M.

    1991-01-01

    Primary bone malignancies are relatively rare with less than 4,000 new cases per year. Multiple myeloma (more correctly a hematologic malignancy) accounts for 40%; osteosarcomas, 28%; chondrosarcomas, 13%; fibrosarcomas arising in bone, 4%; and Ewing's sarcoma, 7%. The authors discuss various treatments for bone tumors, including radiotherapy, chemotherapy and surgery

  18. Clinical Effect of Tendon-regulation and Bone-setting Manipulation Combined with Facilitated Stretching in Treatment of Old Ankle Joint Sprain: An Analysis of 30 Cases%理筋正骨手法联合易化牵伸术治疗陈旧性踝关节扭伤30例

    Institute of Scientific and Technical Information of China (English)

    王波; 陈朝晖; 程露露; 张文娣

    2017-01-01

    Objective To investigate the clinical effect of tendon-regulation and bone-setting manipulation combined with facilitated stretching in the treatment of old ankle joint sprain.Methods A total of 60 patients with old ankle joint sprain were randomly divided into treatment group and control group using a randomized controlled design, with 30 patients in each group.The patients in the treatment group were given tendon-regulation and bone-setting manipulation combined with facilitated stretching, and those in the control group were given electromagnetic radiation and acupuncture.The Baird-Jackson ankle joint function score, Visual Analogue Scale (VAS) score, and tenderness score were compared after two courses of treatment.Results Both groups had significant improvements in the VAS score, Baird-Jackson ankle joint function score, and tenderness score after treatment, and the treatment group had significantly better improvements than the control group (P<0.05).Conclusion In patients with old ankle joint sprain, tendon-regulation and bone-setting manipulation combined with facilitated stretching can improve their symptoms and clinical outcome.%目的 观察中医理筋正骨手法联合易化牵伸术治疗陈旧性踝关节扭伤的疗效.方法 采用随机对照的方法,将60例陈旧性踝关节扭伤患者随机分为治疗组和对照组,每组30例,治疗组采用理筋正骨手法联合易化牵伸术治疗,对照组采用电磁波治疗仪照射和针刺治疗,治疗2个疗程后分别比较患者Baird-Jackson踝关节功能评分、疼痛视觉模拟评分(visual analogue scale,VAS)以及压痛程度评分的差异.结果 治疗后2组患者VAS评分、压痛程度评分、Baird-Jackson踝关节功能评分较本组治疗前显著改善(P<0.05),且治疗组各评价指标改善程度显著大于对照组(P<0.05).结论 理筋正骨手法联合易化牵伸术可以改善陈旧性踝关节扭伤患者症状,提高临床疗效.

  19. Vital signs : all gauges register a lasting surge in activity

    International Nuclear Information System (INIS)

    Lunan, D.

    2000-01-01

    The petroleum and natural gas industry is currently in the midst of a surge in activity with respect to land sales and metres drilled just to meet the demand, particularly for natural gas. Land sale activity is considered to be a key indicator for forecasting drilling activity. Drilling activity is also up since producers are trying to find new reserves to meet future years of forecasted strong demand growth, particularly from the United States. In one year, since June 1999, the average price paid for oil and gas rights rose nearly 80 per cent to just under $300 per hectare. Lease and licence bonus payments were also up from $27 million to $72.1 million. The surge in drilling activity has resulted in all basins reporting at least modest improvements. In the Western Canadian Sedimentary Basin, completions in Alberta for the first half of year 2000 were up 10 per cent with gas wells ahead of oil completions by a two-to-one margin. Exploration drilling is down compared to development drilling because of immediate demand expectations. Overall, industry drilled about 1.6 million metres of hole through the first half of year 2000, up from just over 5 million metres last year. More attention is being given to deeper gas plays. Total expenditures are forecasted to exceed the $30 billion mark, up from $26.3 billion last year and surpassing the $28 billion spent during Canada's big drilling boom in 1997. With crude oil prices holding up and gas prices running to record levels due to strong demand and low storage reserves, revenues this year will jump to nearly $42 billion from about $32.5 billion in 1999. The following industry charts for the first half of year 2000 were included: (1) well depths, (2) success ratios of well completions, (3) Canadian petroleum production, (4) Canadian exploration and production revenues and expenditures, and (5) land sale summaries. 5 tabs., 1 fig

  20. The application of magnetic resonance imaging in temporomandibular joint pathology

    International Nuclear Information System (INIS)

    Ehmedov, E.T.; Qahramanov, E.T.

    2007-01-01

    The diseases and damages of temporomandibular joint have compleceted diagnostic unlike other bone-joint pathologies. In 2005 for the first time in history it was implemented the magnetic resonance imaging in diagnostics of patients with with temporomandibular joints pathology. The current researches are in place till today. Being the golden standart the application of magnetic resonance tomography has a great role in differential diagnostics of the chronic arthritis, sclerosanse, deformanse arthrosis and arthrosis with internal derancement. This method guaranteed the correct valuation of the bone, disc and muscle structures of the joint and therefore brought full clearance into the problem

  1. Role of cold surge and MJO on rainfall enhancement over indonesia during east asian winter monsoon

    Science.gov (United States)

    Fauzi, R. R.; Hidayat, R.

    2018-05-01

    Intensity of precipitation in Indonesia is influenced by convection and propagation of southwest wind. Objective of this study is to analyze the relationship between cold surge and the phenomenon of intra-seasonal climate variability Madden-julian Oscillation (MJO) for affecting precipitation in Indonesia. The data used for identifying the occurrence of cold surge are meridional wind speed data from the ERA-Interim. In addition, this study also used RMM1 and RMM2 index data from Bureau of Meteorology (BOM) for identifying MJO events. The results showed that during East Asian Winter Monsoon (EAWM) in 15 years (2000-2015), there are 362 cold surge events, 186 MJO events, and 113 cold surge events were associated with MJO events. The spread of cold surge can penetrate to equator and brought mass of water vapor that causes dominant precipitation in the Indonesian Sea up to 50-75% from climatological precipitation during EAWM. The MJO convection activity that moves from west to east also increases precipitation, but the distribution of rainfall is wider than cold surge, especially in Eastern Indonesia. MJO and cold surge simultaneously can increase rainfall over 100-150% in any Indonesian region that affected by MJO and cold surge events. The mechanism of heavy rainfall is illustrated by high activity of moisture transport in areas such as Java Sea and coastal areas of Indonesia.

  2. Role of exogenous estrogen in initiation of estrus and induction of an LH surge

    Science.gov (United States)

    Among cattle the LH surge that causes ovulation occurs shortly after the onset of a spontaneous estrus. In addition an injection of 100 'g of GnRH can induce an LH surge capable of inducing ovulation. We hypothesized that different preovulatory estradiol profiles would result in different ovulator...

  3. Storm surge in the Bay of Bengal and Arabian Sea: The problem and its prediction

    Digital Repository Service at National Institute of Oceanography (India)

    Dube, S.K.; Rao, A.D.; Sinha, P.C.; Murty, T.S.; Bahulayan, N.

    to annual economic losses in these countries. Thus, the real time monitoring and warning of storm surge is of great concern for this region. The goal of this paper is to provide an overview of major aspects of the storm surge problem in the Bay of Bengal...

  4. Numerical modelling of tides and storm surges in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Sindhu, B.

    were done. A storm surge model was developed to simulate total water levels and derived surges caused by low pressure systems identified during the past 27 years (1974-2000) in the Bay of Bengal. Study also estimated the return levels of extreme sea...

  5. Data Assimilation within the Advanced Circulation (ADCIRC) Modeling Framework for Hurricane Storm Surge Forecasting

    KAUST Repository

    Butler, T.; Altaf, Muhammad; Dawson, C.; Hoteit, Ibrahim; Luo, X.; Mayo, T.

    2012-01-01

    levels, and wave heights—during these extreme events. This type of data, if available in real time, could be used in a data assimilation framework to improve hurricane storm surge forecasts. In this paper a data assimilation methodology for storm surge

  6. Effect of Tide Elevation on Extratropical Storm Surge in Northwest Europe

    Science.gov (United States)

    Keshtpoor, M.; Carnacina, I.; Yablonsky, R. M.

    2016-12-01

    Extratropical cyclones (ETCs) are the major storm surge-generating meteorological events in northwest Europe. The total water level increase induced by these ETCs is significantly influenced by the local tidal range, which exceeds 8 meters along the southwestern UK coastline. In particular, a surge-generating ETC during high tide may put coastal assets and infrastructure in risk. Also, during low tide, the risk of surge induced by extreme ETC events is diminished. Here, the effect of tidal elevation on storm surge is investigated at 196 tide gauges in northwest Europe. A numerical, hydrodynamic model was developed using Delft3D-FM framework to simulate the coastal hydrodynamics during ETCs. Then, 1750 historical events were simulated to investigate the pattern of coastal inundation. Results suggest that in areas with a large tidal range ( 8 meters) and during the time period surrounding high or low tide, the pattern of coastal hydrodynamics is governed by tide and not storm surge. This result is most evident near the English Channel and Bristol Channel, where low frequency maximum water levels are observed when storm surge is combined with high tide. In contrast, near the tidal phase reversal, coastal hydrodynamics responds primarily to the storm surge, and low frequency maximum water elevation largely depends on the surge. In the areas with a small tidal range, ETC strength determines the pattern of coastal inundation.

  7. Artificial Neural Network forecasting of storm surge water levels at major estuarine ports to supplement national tide-surge models and improve port resilience planning

    Science.gov (United States)

    French, Jon; Mawdsley, Robert; Fujiyama, Taku; Achuthan, Kamal

    2017-04-01

    Effective prediction of tidal storm surge is of considerable importance for operators of major ports, since much of their infrastructure is necessarily located close to sea level. Storm surge inundation can damage critical elements of this infrastructure and significantly disrupt port operations and downstream supply chains. The risk of surge inundation is typically approached using extreme value analysis, while short-term forecasting generally relies on coastal shelf-scale tide and surge models. However, extreme value analysis does not provide information on the duration of a surge event and can be sensitive to the assumptions made and the historic data available. Also, whilst regional tide and surge models perform well along open coasts, their fairly coarse spatial resolution means that they do not always provide accurate predictions for estuarine ports. As part of a NERC Environmental Risks to Infrastructure Innovation Programme project, we have developed a tool that is specifically designed to forecast the North Sea storm surges on major ports along the east coast of the UK. Of particular interest is the Port of Immingham, Humber estuary, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. A tidal surge in December 2013, with an estimated return period of 760 years, partly flooded the port, damaged infrastructure and disrupted operations for several weeks. This and other recent surge events highlight the need for additional tools to supplement the national UK Storm Tide Warning Service. Port operators are also keen to have access to less computationally expensive forecasting tools for scenario planning and to improve their resilience to actual events. In this paper, we demonstrate the potential of machine learning methods based on Artificial Neural Networks (ANNs) to generate accurate short-term forecasts of extreme water levels at estuarine North Sea ports such as Immingham. An ANN is

  8. Patterns of magnetic resonance imaging bone erosion in rheumatoid arthritis--which bones are most frequently involved and show the most change?

    DEFF Research Database (Denmark)

    Ostergaard, Mikkel; Møller Døhn, Uffe; Duer-Jensen, Anne

    2011-01-01

    To investigate by magnetic resonance imaging (MRI) which bones in wrists and metacarpophalangeal (MCP) joints most frequently show bone erosions, and which most frequently demonstrate erosive progression, in early and established rheumatoid arthritis (RA).......To investigate by magnetic resonance imaging (MRI) which bones in wrists and metacarpophalangeal (MCP) joints most frequently show bone erosions, and which most frequently demonstrate erosive progression, in early and established rheumatoid arthritis (RA)....

  9. Osseous temporomandibular joint abnormalities in rheumatic disease

    International Nuclear Information System (INIS)

    Larheim, T.A.; Kolbenstvedt, A.; Rikshospitalet, Oslo

    1990-01-01

    Computed tomography (CT) of the temporomandibular joint (TMJ) was compared with hypocycloidal tomography in 30 joints of 15 adults with rheumatic disease. CT included 1.5 mm thick axial scans (at 1.0 mm intervals) with reformatted oblique sagittal and oblique coronal sections. Multisection (at 2.0 mm intervals) tomography included oblique sagittal and occasionally, oblique coronal sections. CT demonstrated bone abnormalities in 21 and tomography in 20 joints, indicating high agreement between the imaging modalities regarding number of abnormal TMJs. Bone structures were, however, better visualized by multiplanar CT due to superior contrast and spatial resolution particularly in the most lateral and medial parts of the joint, indicating superiority of CT for depicting subtle bony TMJ abnormalities in patients with rheumatic disease. (orig.)

  10. Distal radioulnar joint: functional anatomy, including pathomechanics.

    Science.gov (United States)

    Haugstvedt, J R; Langer, M F; Berger, R A

    2017-05-01

    The distal radioulnar joint allows the human to rotate the forearm to place the hand in a desired position to perform different tasks, without interfering with the grasping function of the hand. The ulna is the stable part of the forearm around which the radius rotates; the stability of the distal radioulnar joint is provided by the interaction between ligaments, muscles and bones. The stabilizing structures are the triangular fibrocartilage complex, the ulnocarpal ligament complex, the extensor carpi ulnaris tendon and tendon sheath, the pronator quadratus, the interosseous membrane and ligament, the bone itself and the joint capsule. The purpose of this review article is to present and illustrate the current understanding of the functional anatomy and pathomechanics of this joint.

  11. Scintigraphic presentation of hip joint synovial chondromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Zwas, S T; Friedman, B; Nerubay, J

    1988-09-01

    A case of hip joint synovial chondromatosis with an unusual scintigraphic pattern is described. This pattern was suggestive of a hip joint destructive reactive articular process or late manifestations of avascular necrosis of the femoral head. Concurrent radiographs were normal, as were laboratory investigations. Follow-up radiographs six months later showed radiolucencies and erosive bone changes in the diseased joint. Surgical and histopathological findings revealed well developed hip synovial chondromatosis (HSC) with thickened synovium and large, loose, cartilaginous bodies occupying and widening the tightened joint space, with destructive secondary juxta articular pressure and bone erosions. This and other scintigraphic patterns in HSC, and the differential diagnosis of the findings in patients with painful hip presentations are discussed.

  12. Joint purpose?

    DEFF Research Database (Denmark)

    Pristed Nielsen, Helene

    2013-01-01

    Starting from Crenshaw´s point that antiracism often fails to interrogate patriarchy and that feminism often reproduces racist practices (1991: 1252), this paper asks: What are the theoretical reasons for believing that feminism and anti-racism can be regarded as fighting for the joint purpose...

  13. Quantification of Sediment Transport During Glacier Surges and its Impact on Landform Architecture

    DEFF Research Database (Denmark)

    Kjær, Kurt H.; Schomacker, Anders; Korsgaard, Niels Jákup

    ) for 1945, prior to the last surge in 1964, and for 2003 in order to assess the effect of the surge on the sediment architecture in the forefield. The pre- and post-surge DEMs allow direct quantification of the sediment volumes that were re-distributed in the forefield by the surging ice mass in 1964...... or glaciofluvial outwash fans. Mapping of the sediment thickness in the glacier forefield shows higher accumulation along ice marginal positions related to wedge formation during extremely rapid ice flow. Fast flow was sustained by overpressurized water causing sediment-bedrock decoupling beneath a thick sediment...... architecture occurs distal to the 1810 ice margin, where the 1890 surge advanced over hitherto undeformed sediments. Proximal to the 1810 ice margin, the landscape have been transgressed by either one or two glaciers (in 1890 and 1964). The most complex landscape architecture is found proximal to the 1964 ice...

  14. Progression of the 2011-2012 Surge of Bering Glacier and Bagley Ice Field, Alaska

    Science.gov (United States)

    Herzfeld, U. C.; McDonald, B.; Stachura, M.; Hale, R.; Trantow, T.; Weltman, A.; Chen, P.

    2012-12-01

    Bering Glacier, Alaska, started a surge in late spring 2011. The surge reached the ice front in May 2011 and extended into Bagley Ice Field by summer 2011. New surge-related crevassing was observed in July 2012. We collected aerial observations, including systematic videographic and photographic imagery, GPS data and laser altimeter data in September 2011 and in July 2012. In this talk, an analysis of surge progression and comparison to the early, mature and late stages of the 1993-1995 surge of Bering Glacier and Bagley Ice Field will be presented. A suite of approaches will be used to this end: Analysis of elevation changes based on CryoSat data, 2009 and 2010 IceBridge data and 2011 and 2012 laser altimeter data collected by our group, geostatistical classification of crevasse types based on imagery, classification of laser altimeter data and analysis of high-resolution satellite imagery (Worldview and GEOS).

  15. Hurricane storm surge and amphibian communities in coastal wetlands of northwestern Florida

    Science.gov (United States)

    Gunzburger, M.S.; Hughes, W.B.; Barichivich, W.J.; Staiger, J.S.

    2010-01-01

    Isolated wetlands in the Southeastern United States are dynamic habitats subject to fluctuating environmental conditions. Wetlands located near marine environments are subject to alterations in water chemistry due to storm surge during hurricanes. The objective of our study was to evaluate the effect of storm surge overwash on wetland amphibian communities. Thirty-two wetlands in northwestern Florida were sampled over a 45-month period to assess amphibian species richness and water chemistry. During this study, seven wetlands were overwashed by storm surge from Hurricane Dennis which made landfall 10 July 2005 in the Florida panhandle. This event allowed us to evaluate the effect of storm surge overwash on water chemistry and amphibian communities of the wetlands. Specific conductance across all wetlands was low pre-storm (marine habitats are resistant to the effects of storm surge overwash. ?? 2010 Springer Science+Business Media B.V.

  16. Condition Assessment of Metal Oxide Surge Arrester Based on Multi-Layer SVM Classifier

    Directory of Open Access Journals (Sweden)

    M Khodsuz

    2015-12-01

    Full Text Available This paper introduces the indicators for surge arrester condition assessment based on the leakage current analysis. Maximum amplitude of fundamental harmonic of the resistive leakage current, maximum amplitude of third harmonic of the resistive leakage current and maximum amplitude of fundamental harmonic of the capacitive leakage current were used as indicators for surge arrester condition monitoring. Also, the effects of operating voltage fluctuation, third harmonic of voltage, overvoltage and surge arrester aging on these indicators were studied. Then, obtained data are applied to the multi-layer support vector machine for recognizing of surge arrester conditions. Obtained results show that introduced indicators have the high ability for evaluation of surge arrester conditions.

  17. Bone banking.

    Science.gov (United States)

    Howard, W

    1999-04-01

    The use of human organs and tissues for transplantation in Australia has increased significantly over the past 30 years. In 1997, the Australian Coordinating Committee on Organ Registries and Donation (ACCORD) reported a total number of 190 organ donors, 636 corneal donors and 1509 bone donors Australia wide. Of the 1509 bone donations, 143 came from cadaveric sources and 1366 were made by living donors. Bone transplantation is not as widely recognised as solid organ or corneal transplantation. Due to improved technology and surgical skills, the demand for bone transplantation has increased markedly. This Clinical Update will provide an overview of the physiological aspects of bone transplantation and explore bone banking, a key step in the complex and critical process of bone transplantation.

  18. Storm surge and wave simulations in the Gulf of Mexico using a consistent drag relation for atmospheric and storm surge models

    Directory of Open Access Journals (Sweden)

    D. Vatvani

    2012-07-01

    Full Text Available To simulate winds and water levels, numerical weather prediction (NWP and storm surge models generally use the traditional bulk relation for wind stress, which is characterized by a wind drag coefficient. A still commonly used drag coefficient in those models, some of them were developed in the past, is based on a relation, according to which the magnitude of the coefficient is either constant or increases monotonically with increasing surface wind speed (Bender, 2007; Kim et al., 2008; Kohno and Higaki, 2006. The NWP and surge models are often tuned independently from each other in order to obtain good results. Observations have indicated that the magnitude of the drag coefficient levels off at a wind speed of about 30 m s−1, and then decreases with further increase of the wind speed. Above a wind speed of approximately 30 m s−1, the stress above the air-sea interface starts to saturate. To represent the reducing and levelling off of the drag coefficient, the original Charnock drag formulation has been extended with a correction term.

    In line with the above, the Delft3D storm surge model is tested using both Charnock's and improved Makin's wind drag parameterization to evaluate the improvements on the storm surge model results, with and without inclusion of the wave effects. The effect of waves on storm surge is included by simultaneously simulating waves with the SWAN model on identical model grids in a coupled mode. However, the results presented here will focus on the storm surge results that include the wave effects.

    The runs were carried out in the Gulf of Mexico for Katrina and Ivan hurricane events. The storm surge model was initially forced with H*wind data (Powell et al., 2010 to test the effect of the Makin's wind drag parameterization on the storm surge model separately. The computed wind, water levels and waves are subsequently compared with observation data. Based on the good

  19. Regional Risk Assessment for the analysis of the risks related to storm surge extreme events in the coastal area of the North Adriatic Sea.

    Science.gov (United States)

    Rizzi, Jonathan; Torresan, Silvia; Gallina, Valentina; Critto, Andrea; Marcomini, Antonio

    2013-04-01

    stations located in the North Adriatic coastal areas from 1989 to 2011. These data, together with the sea-level rise scenarios for the considered future timeframe, represent the input for the application of the Joint Probability method (Pugh and Vassie, 1979), which allows the evaluation of the maximum height of extreme storm surge events with different return period and the number of extreme events per year. The methodology uses Geographic Information Systems to manage, process, analyse, and visualize data and employs Multi-Criteria Decision Analysis to integrate stakeholders preferences and experts judgments into the analysis in order to obtain a total risk index in the considered region. The final outputs are represented by GIS-based risk maps which allow the communication of the potential consequences of extreme storm surge to decision makers and stakeholders. Moreover, they can support the establishment of relative priorities for intervention through the identification of suitable areas for human settlements, infrastructures and economic activities. Finally the produced output can represent a basis for definition of storm surge hazard and storm surge risk management plans according to the Floods Directive. The preliminary results of the RRA application in the CLIMDAT project will be here presented and discussed.

  20. Transient Pressure Surges Due to Pipe Movement in an Oil Well Surpressions transitoires dues au mouvement des colonnes de tubes dans les puits.

    Directory of Open Access Journals (Sweden)

    Lubinski A.

    2006-11-01

    Full Text Available A pressure surge which could cause lost circulation, results from running a stand of drill pipe or a joint of casing into a hole. Similarly, a negative pressure surge, which could cause a blowout, results from pulling pipe from a hole. In past investigations, pressure surges were calculated on the basis of steady state flow. It is shown in this paper that this led to erroneous results. In thls investigation, pressure surges are calculated on the basis of transient wave propagation phenomena. A computer program was developed to that effect. Results are presented in :the first part of the paper, and the mathematics in the second. La descente d'une longueur de tiges ou d'un tube de casing dans le trou provoque une surpression pouvant entraîner des pertes de circulation. De même, la remontée des tiges provoque une surpression négative pouvant entraîner une éruption. Au cours des précédentes recherches, les surpressions étaient calculées pour des débits en régime permanent. Il est montré dans cet étude que les résultats ainsi obtenus ne sont pas exacts. Dans cette recherche, les calculs des surpressions sont basés sur le phénomène de propagation transitoire des ondes. Un programme de calcul sur ordinateur a été développé à cet effet. Les résultats sont présentés dans la première partie de cet article et les calculs font l'objet de la deuxième partie.

  1. Potential Hydrodynamic Loads on Coastal Bridges in the Greater New York Area due to Extreme Storm Surge and Wave

    Science.gov (United States)

    2018-04-18

    This project makes a computer modeling study on vulnerability of coastal bridges in New York City (NYC) metropolitan region to storm surges and waves. Prediction is made for potential surges and waves in the region and consequent hydrodynamic load an...

  2. Remoção da cartilagem articular associada ou não a implante homógeno ou enxerto autógeno de osso esponjoso em cães submetidos à artrodese atlantoaxial Joint cartilage removal associated or not to homologous implant or autologous cancellous bone graft in dogs submitted to atlantoaxial arthrodesis

    Directory of Open Access Journals (Sweden)

    Rafael Festugatto

    2013-03-01

    Full Text Available O objetivo deste estudo foi avaliar o grau de fusão articular e formação óssea na articulação atlantoaxial de cães submetidos à artrodese após a remoção da cartilagem articular associada ou não ao implante homógeno ou enxerto autógeno de osso esponjoso. Foram utilizados 12 cães, adultos, distribuídos aleatoriamente em três grupos iguais. Grupo I (GI: realizada apenas a remoção da cartilagem articular e imobilização articular com pinos e resina acrílica. Grupo II (GII: feita a remoção da cartilagem articular e imobilização da articulação, seguida da colocação e modelagem do implante ósseo esponjoso homógeno entre as superfícies articulares. Grupo III (GIII: foi realizado o mesmo procedimento do GII, mais o enxerto ósseo esponjoso autógeno no local determinado. Realizaram-se exames radiográficos em todos os animais aos 30, 60 e 90 dias de pós-operatório (PO. Aos 90 dias de PO foi feita a eutanásia para o emprego do teste de palpação manual, avaliação tomográfica e histopatológica. Para análise estatística da associação entre o grau de fusão articular, aplicou-se o Teste Qui-quadrado de independência. Os resultados dos testes foram avaliados pela significância exata e considerados significantes a 5% (PThe aim of this study was to evaluate the degree of joint fusion and bone formation in dogs undergoing atlantoaxial arthrodesis after removal of articular cartilage associated or not to implant homogenous or autogenous cancellous bone. Twelve dogs, weighing between 8 and 12kg were randomly divided into three groups. Group I (GI performed only the removal of joint cartilage and joint immobilization with acrylic resin and pins. Group II (GII: after removel of joint cartilage and articular immobilization was performed modeling and placement of homogenous cancellous bone at the given location. The volume of homograft placed in the joint was measured using a precision balance and all animals received the

  3. Bone scintigraphy and osteo-articular tuberculosis in transplant patients: a study of 50 bone scans

    International Nuclear Information System (INIS)

    Coulaud, J.P.; Mechali, D.; Morau, G.

    1982-01-01

    Bone scintigraphy with 99 m technecium labelled phosphorus compounds was achieved in 50 west Africans migrant workers in Paris. Bone and joint tuberculosis was assumed in 20 cases. In 5 of these 20 cases, bone scan, but not X-ray, showed abnormalities, and in 4, bone scan disclosed more localisations than X-rays. In 7 cases, yet, bone scan was normal, with major osteolytic X-rays lesions in 3 cases, minor in 2 cases, and isolated cold abcesses in two more cases: these means 7 false-negative results. Among the 30 other cases, 29 were considered as mechanical vertebral pathology, and 1 sacro-iliitis Brucellosis. Bone scan was normal in 28 cases the 2 others are unexplained false-positive. Although non-specific and not completely reliable, we think that bone-scanning is useful in bone-tuberculosis check-up, especially to obtain early diagnosis and detect multifocal localisations [fr

  4. Bone scintigraphy and osteo-articular tuberculosis in transplant patients: a study of 50 bone scans

    Energy Technology Data Exchange (ETDEWEB)

    Coulaud, J.P.; Mechali, D.; Morau, G. (Hopital Claude-Bernard, Paris (France))

    1982-01-01

    Bone scintigraphy with 99 m technecium labelled phosphorus compounds was achieved in 50 west Africans migrant workers in Paris. Bone and joint tuberculosis was assumed in 20 cases. In 5 of these 20 cases, bone scan, but not X-ray, showed abnormalities, and in 4, bone scan disclosed more localisations than X-rays. In 7 cases, yet, bone scan was normal, with major osteolytic X-rays lesions in 3 cases, minor in 2 cases, and isolated cold abcesses in two more cases: these means 7 false-negative results. Among the 30 other cases, 29 were considered as mechanical vertebral pathology, and 1 sacro-iliitis Brucellosis. Bone scan was normal in 28 cases the 2 others are unexplained false-positive. Although non-specific and not completely reliable, we think that bone-scanning is useful in bone-tuberculosis check-up, especially to obtain early diagnosis and detect multifocal localisations.

  5. Applications and limitations of quantitative sacroiliac joint scintigraphy

    International Nuclear Information System (INIS)

    Goldberg, R.P.; Genant, H.K.; Shimshak, R.; Shames, D.

    1978-01-01

    Evaluation of sacroiliac joint pathology by quantitative analysis of radionuclide bone scanning has been advocated as a useful technique. We have examined this technique in 61 patients and controls. The procedure was useful in detecting early sacroilitis but was of limited value in patients with advanced sacroiliac joint findings radiographically. False positive values were found in patients with metabolic bone disease or structural abnormalities in the low back. Normative data must be determined for each laboratory

  6. Observed characteristics of tide-surge interaction along the east coast of India and the head of Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Antony, C.; Unnikrishnan, A.S.

    before the high tide. Application of a simple model shows the observed surge peak distribution at Hiron Point can be explained in terms of phase alteration of tide due to surge and surge modulation by tide. The degree of interaction tends to increase...

  7. Sterilisation of allograft cortical bone using gamma irradiation: effect on strength and material ultrastructure

    International Nuclear Information System (INIS)

    Price, R.; Walters, M.

    1996-01-01

    Full text: The use of allograft bone in revision joint and limb salvage surgery is widespread and increasing (Buck B.E. et al, Clin Orthop 303: 8-17, 1994). To reduce the risk of disease transmission from donor graft contamination (particularly HIV and hepatitis) sterilisation is practiced worldwide. Gamma (γ)-irradiation using a dose of 1.5 - 2.5 Mrads is common. However, γ-irradiation is known to reduce bone strength, though the extent and mechanisms are controversial (eg Bright RW et al, Trans Orthop Res Soc 3: 210, 1978). We measured the effect of γ-irradiation on bone strength and properties reflecting bone material ultrastructure. Diaphyseal bone was obtained from the femur of a 47 year-old male would-be donor with suspicious hepatitis serology. Beams of cortical bone (long axes parallel to the femur) were cut using a low speed diamond saw bathed in Ringer's solution. Four groups were irradiated with γ-rays (0, 1.5, 2.5 and 5.0±0.5[SD] Mrads). Blinded investigations were performed: Ultimate stress (Ult Stress, N= 16 replicates in each dose group). Each beam was loaded at its midpoint at a rate of 25 mm/min until failure, while its ends were supported 40 mms apart. Ult stress was calculated from 3-point bending theory using the load vs displacement curve and the cross-sectional area of the break (Power RA et al, submitted to J Bone and Joint Surg). Differential scanning calorimetry (DSC) was performed over the range -15 to +5 deg C. Samples were demineralized and small (7-10 mg) blocks were cut and sealed in stainless steel calorimetry capsules. The enthalpy (reflecting the normalised free water content) was calculated from the sample mass plus area under the heat capacity curve. Pyridinoline collagen (acid-insoluble) crosslinks (Pyrid, N=10) (Randall D et al, JBone and Min Res, 1996, in press) were determined from 5-mm 3 demineralised, freeze dried samples. Small and medium angle X-ray diffraction (XRD, N=5). Demineralised bone was sliced into thin

  8. Bone development

    DEFF Research Database (Denmark)

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.

    2007-01-01

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram.......01). Furthermore, AKG administration induced significantly higher bone mineral density of the cortical bone by 7.1% (P

  9. Predicting Typhoon Induced Storm Surges Using the Operational Ocean Forecast System

    Directory of Open Access Journals (Sweden)

    Sung Hyup You

    2010-01-01

    Full Text Available This study was performed to compare storm surges simulated by the operational storm surges/tide forecast system (STORM : Storm surges/Tide Operational Model of the Korea Meteorological Administration (KMA with observations from 30 coastal tidal stations during nine typhoons that occurred between 2005 and 2007. The results (bias showed that for cases of overestimation (or underestimation, storm surges tended to be overestimated (as well as underestimated at all coastal stations. The maximum positive bias was approximately 6.92 cm for Typhoon Ewiniar (2006, while the maximum negative bias was approximately -12.06 cm for Typhoon Khanun (2005. The maximum and minimum root mean square errors (RMSEs were 14.61 and 6.78 cm, which occurred for Typhoons Khanun (2005 and Usagi (2007, respectively. For all nine typhoons, total averaged RMSE was approximately 10.2 cm. Large differences between modeled and observed storm surges occurred in two cases. In the first, a very weak typhoon, such as Typhoon Khanun (2005, caused low storm surges. In the other, exemplified by Typhoon Nari (2007, there were errors in the predicted typhoon strength used as input data for the storm surge model.

  10. Simulating Storm Surge Impacts with a Coupled Atmosphere-Inundation Model with Varying Meteorological Forcing

    Directory of Open Access Journals (Sweden)

    Alexandra N. Ramos Valle

    2018-04-01

    Full Text Available Storm surge events have the potential to cause devastating damage to coastal communities. The magnitude of their impacts highlights the need for increased accuracy and real-time forecasting and predictability of storm surge. In this study, we assess two meteorological forcing configurations to hindcast the storm surge of Hurricane Sandy, and ultimately support the improvement of storm surge forecasts. The Weather Research and Forecasting (WRF model is coupled to the ADvanced CIRCulation Model (ADCIRC to determine water elevations. We perform four coupled simulations and compare storm surge estimates resulting from the use of a parametric vortex model and a full-physics atmospheric model. One simulation is forced with track-based meteorological data calculated from WRF, while three simulations are forced with the full wind and pressure field outputs from WRF simulations of varying resolutions. Experiments were compared to an ADCIRC simulation forced by National Hurricane Center best track data, as well as to station observations. Our results indicated that given accurate meteorological best track data, a parametric vortex model can accurately forecast maximum water elevations, improving upon the use of a full-physics coupled atmospheric-surge model. In the absence of a best track, atmospheric forcing in the form of full wind and pressure field from a high-resolution atmospheric model simulation prove reliable for storm surge forecasting.

  11. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Valued eMachines Customer

    attachment for the gluteus maximus, adductor magnus, adductor brevis, vastus muscles, and the short head of the biceps ... secondary bone tumours and repetitive stress. Injury mechanism and age ... energy injuries are known to occur commonly in the elderly and are due to falls and usually have a local or general factor ...

  12. Joint Operation Planning

    National Research Council Canada - National Science Library

    2006-01-01

    .... It sets forth joint doctrine to govern the joint operation planning activities and performance of the Armed Forces of the United States in joint operations, and provides the joint doctrinal basis...

  13. Surge analysis of the MAGLEV coil for propulsion and guidance; Jiki fujoshiki tetsudo ni okeru suitei annaiyo coil no surge kaiseki

    Energy Technology Data Exchange (ETDEWEB)

    Ema, S [Numazu College of Technology, Shizuoka (Japan)

    1995-11-20

    The MAGLEV (magnetically levitated train) is now well along in development testing in Japan. MAGLEV is unlike conventional railways, so various problems lie in the technology of MAGLEV. One of them is surge analysis of the MAGLEV coil for propulsion and guidance (`coil for propulsion` for short). The coil for propulsion is installed on each side of the outdoor guideway. Thus, the power system of MAGLEV is always exposed to lightning and circuit switching. Accordingly, it is very important to do a rational insulation plan to prevent damage when surges enter the coils. In view of this situation I performed experiments using the mini model coils and clarified impulse voltage distribution at the end of each coil and simulated the surge characteristics by giving the inverted L equivalent circuit to the coil for propulsion. As a result, the measured values and calculated values were almost equal in the surge characteristics. Further, the surge characteristics of the Miyazaki test track and the future MAGLEV were examined. 10 refs., 17 figs., 1 tab.

  14. Radiology of disorders of the sacroiliac joints

    International Nuclear Information System (INIS)

    Resnik, C.S.; Resnick, D.

    1985-01-01

    Many disorders can lead to radiological abnormalities of the sacroiliac joints. Some present a characteristic appearance, while others may be diagnosed by analyzing both the appearance and the distribution of findings. Computed tomography provides excellent visualization of the sacroiliac joints and can be helpful in the evaluation of articular disorders as well as pelvic trauma and neoplasms. Radionuclide scanning of bone can also be used to evaluate the sacroiliac joints, particularly if the two sides are compared with the assistance of computer-generated activity counts. This article describes the radiological features of these various disorders that often allow an exact diagnosis to be made

  15. Contributions of Severe Burn and Disuse to Bone Structure and Strength in Rats

    Science.gov (United States)

    2013-01-01

    hydroxyapatite phantom to ensure CT value Hounsfeld Units consistency. Each bone was imaged at 80 kVp, 80 μA, and at a resolution level producing isotropic 25 μm...Surg Res 2003;114:172-8. [16] Klein GL, Herndon DN, Goodman WG, Langman CB, Phillips WA, Dickson IR , et al. Histomorphometric and biochemical

  16. Developing an early warning system for storm surge inundation in the Philippines

    Science.gov (United States)

    Tablazon, J.; Caro, C. V.; Lagmay, A. M. F.; Briones, J. B. L.; Dasallas, L.; Lapidez, J. P.; Santiago, J.; Suarez, J. K.; Ladiero, C.; Gonzalo, L. A.; Mungcal, M. T. F.; Malano, V.

    2014-10-01

    A storm surge is the sudden rise of sea water generated by an approaching storm, over and above the astronomical tides. This event imposes a major threat in the Philippine coastal areas, as manifested by Typhoon Haiyan on 8 November 2013 where more than 6000 people lost their lives. It has become evident that the need to develop an early warning system for storm surges is of utmost importance. To provide forecasts of the possible storm surge heights of an approaching typhoon, the Nationwide Operational Assessment of Hazards under the Department of Science and Technology (DOST-Project NOAH) simulated historical tropical cyclones that entered the Philippine Area of Responsibility. Bathymetric data, storm track, central atmospheric pressure, and maximum wind speed were used as parameters for the Japan Meteorological Agency Storm Surge Model. The researchers calculated the frequency distribution of maximum storm surge heights of all typhoons under a specific Public Storm Warning Signal (PSWS) that passed through a particular coastal area. This determines the storm surge height corresponding to a given probability of occurrence. The storm surge heights from the model were added to the maximum astronomical tide data from WXTide software. The team then created maps of probable area inundation and flood levels of storm surges along coastal areas for a specific PSWS using the results of the frequency distribution. These maps were developed from the time series data of the storm tide at 10 min intervals of all observation points in the Philippines. This information will be beneficial in developing early warnings systems, static maps, disaster mitigation and preparedness plans, vulnerability assessments, risk-sensitive land use plans, shoreline defense efforts, and coastal protection measures. Moreover, these will support the local government units' mandate to raise public awareness, disseminate information about storm surge hazards, and implement appropriate counter

  17. The third oil price surge. What's different this time?

    International Nuclear Information System (INIS)

    Kesicki, Fabian

    2010-01-01

    The period from 2003 to 2008 was marked by an oil price increase comparable to the two oil price crises in the 1970s. This paper looks in detail at the situation of the oil price crises 30 years ago and compares them along various aspects on the demand and supply side with the recent price increase to identify similarities and differences. While both oil price crises in 1973 and 1979/1980 were ultimately caused by supply actions of members of the Organisation of Petroleum Exporting Countries (OPEC), all three oil price crises were preceded by high demand growth. Other aspects that favoured a high oil price in all three cases were low investments in new oil fields, as a consequence low spare capacity, and a weak US dollar. In addition, the recent oil price surge has been characterised by a high global refinery utilisation and refineries that did not adapt fast enough to the rising demand for lighter oil products. Moreover, broader geopolitical uncertainties, combined with risks associated with the oil trade helped push the oil price into a triple-digit zone. Speculation played only a limited and temporary role in accelerating price movements during the recent price increase. (author)

  18. Smart Ultrasound Remote Guidance Experiment (SURGE) Preliminary Findings

    Science.gov (United States)

    Hurst, Victor; Dulchavsky, Scott; Garcia, Kathleen; Sargsyan, Ashot; Ebert, Doug

    2009-01-01

    To date, diagnostic quality ultrasound images were obtained aboard the International Space Station (ISS) using the ultrasound of the Human Research Facility (HRF) rack in the Laboratory module. Through the Advanced Diagnostic Ultrasound in Microgravity (ADUM) and the Braslet-M Occlusion Cuffs (BRASLET SDTO) studies, non-expert ultrasound operators aboard the ISS have performed cardiac, thoracic, abdominal, vascular, ocular, and musculoskeletal ultrasound assessments using remote guidance from ground-based ultrasound experts. With exploration class missions to the lunar and Martian surfaces on the horizon, crew medical officers will necessarily need to operate with greater autonomy given communication delays (round trip times of up to 5 seconds for the Moon and 90 minutes for Mars) and longer periods of communication blackouts (due to orbital constraints of communication assets). The SURGE project explored the feasibility and training requirements of having non-expert ultrasound operators perform autonomous ultrasound assessments in a simulated exploration mission outpost. The project aimed to identify experience, training, and human factors requirements for crew medical officers to perform autonomous ultrasonography. All of these aims pertained to the following risks from the NASA Bioastronautics Road Map: 1) Risk 18: Major Illness and Trauna; 2) Risk 20) Ambulatory Care; 3) Risk 22: Medical Informatics, Technologies, and Support Systems; and 4) Risk 23: Medical Skill Training and Maintenance.

  19. Lightning and surge protection of large ground facilities

    Science.gov (United States)

    Stringfellow, Michael F.

    1988-04-01

    The vulnerability of large ground facilities to direct lightning strikes and to lightning-induced overvoltages on the power distribution, telephone and data communication lines are discussed. Advanced electrogeometric modeling is used for the calculation of direct strikes to overhead power lines, buildings, vehicles and objects within the facility. Possible modes of damage, injury and loss are discussed. Some appropriate protection methods for overhead power lines, structures, vehicles and aircraft are suggested. Methods to mitigate the effects of transients on overhead and underground power systems as well as within buildings and other structures are recommended. The specification and location of low-voltage surge suppressors for the protection of vulnerable hardware such as computers, telecommunication equipment and radar installations are considered. The advantages and disadvantages of commonly used grounding techniques, such as single point, multiple and isolated grounds are compared. An example is given of the expected distribution of lightning flashes to a large airport, its buildings, structures and facilities, as well as to vehicles on the ground.

  20. The Danger of Deja Vu: Why the Iraq Surge is Not a Lesson for Afghanistan

    Science.gov (United States)

    2010-01-01

    JAN 2010 2. REPORT TYPE 3. DATES COVERED 00-12-2009 to 00-01-2010 4. TITLE AND SUBTITLE The danger of deja vu . Why the Iraq surge is not a lesson...of five brigade combat teams — eerily mim- icked the surge number for Iraq. And there was more déjà vu when our senior civilian and military leaders...Department. PERSPECTIVES The danger of déjà vu Why the Iraq surge is not a lesson for Afghanistan BY COL. CHARLES D. ALLEN (RET.) The thing we take hold of

  1. Introduction to skeletal radiology and bone growth

    International Nuclear Information System (INIS)

    Rogers, L.F.

    1987-01-01

    Radiographic examination is the key to the diagnosis of many skeletal abnormalities. It is essential that each bone be examined in its entirety, including the cortex, medullary canal (cancellous bone or spongiosa), and articular ends. The position and alignment of joints are determined. In children, the epiphysis and epiphyseal line or physis must be observed. The adjacent soft tissues are examined. Obliteration of normal soft-tissue lines and the presence of a joint effusion are of particular importance. When disease is present, it is important to determine whether the process is limited to a single bone or joint or whether multiple bones or joints are involved. The distribution of disease is also a consideration. The presence and type of bone destruction and bone production, the appearance of the edges or borders of the lesion, and the presence or absence of cortical expansion and periosteal reaction are also noted. The radiographic findings are then correlated with the clinical history and the age and sex of the patient to arrive at a logical diagnosis. The diagnosis may be firm in some instances; in other cases, a differential diagnosis is offered since the exact diagnosis cannot be determined

  2. Broken bone

    Science.gov (United States)

    ... Drugs & Supplements Videos & Tools Español You Are Here: Home → Medical Encyclopedia → Broken bone URL of this page: //medlineplus.gov/ency/ ... following steps to reduce your risk of a broken bone: Wear protective ... pads. Create a safe home for young children. Place a gate at stairways ...

  3. Biochemical Markers of Joint Tissue Turnover

    DEFF Research Database (Denmark)

    Bay-Jensen, Anne-Christine; Sondergaard, Bodil Cecilie; Christiansen, Claus

    2009-01-01

    available for the study of tissue turnover in each of the three compartments of the articular joint, that is the bone, the cartilage, and the synovium. Finally, we provide some perspective to future developments in biomarker discovery and discuss the potential impact such technologies could have on the drug...

  4. Management of Aromatase Inhibitor-Associated Bone Loss (AIBL in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG

    Directory of Open Access Journals (Sweden)

    Peyman Hadji

    2017-06-01

    Conclusions: In all patients initiating AI treatment, fracture risk should be assessed and recommendation with regard to exercise and calcium/vitamin D supplementation given. Bone-directed therapy should be given to all patients with a T-score−1.5 SD and no risk factors should be managed based on BMD loss during the first year and the local guidelines for postmenopausal osteoporosis. Compliance should be regularly assessed as well as BMD on treatment after 12 - 24 months. Furthermore, because of the decreased incidence of bone recurrence and breast cancer specific mortality, adjuvant bisphosphonates are recommended for all postmenopausal women at significant risk of disease recurrence.

  5. Bone densitometry

    DEFF Research Database (Denmark)

    Ravn, Pernille; Alexandersen, P; Møllgaard, A

    1999-01-01

    The bisphosphonates have been introduced as alternatives to hormone replacement therapy (HRT) for the treatment and prevention of postmenopausal osteoporosis. The expected increasing application in at clinical practice demands cost-effective and easily handled methods to monitor the effect on bone....... The weak response at the distal forearm during antiresorptive treatment has restricted the use of bone densitometry at this region. We describe a new model for bone densitometry at the distal forearm, by which the response obtained is comparable to the response in other regions where bone densitometry...... is much more expensive and technically complicated. By computerized iteration of single X-ray absorptiometry forearm scans we defined a region with 65% trabecular bone. The region was analyzed in randomized, double-masked, placebo- controlled trials: a 2-year trial with alendronate (n = 69), a 1-year...

  6. How many joints does the 5th toe have? A review of 606 patients of 655 foot radiographs.

    LENUS (Irish Health Repository)

    Moulton, Lawrence Stephen

    2012-12-01

    It is a common understanding that the fifth toe has three bones with two interphalangeal joints. However, our experience shows that a significant number have only two phalanges with one interphalangeal joint.

  7. The effect of bone marrow aspirate, bone graft and collagen composites on fixation of bone implants

    DEFF Research Database (Denmark)

    Babiker, Hassan; Ding, Ming; Overgaard, Søren

    2007-01-01

     Introduction: Replacement of extensive local bone loss especially in revision joint arthroplasties is a significant clinical challenge. Autogenous and allogenic cancellous bone grafts have been the gold standard in reconstructive orthopaedic surgery, but it is well known that there is morbidity...... associated with harvesting of autogenous bone graft and limitations in the quantity of bone available. Disadvantages of allograft include the risk of bacterial or viral contamination and non union as well as the potential risk of disease transmission. Alternative options are attractive and continue...... to be sought. Hydroxyapatite and collagen composites have the potential in mimicking and replacing skeletal bones. Aim: This study attempted to determine the effect of hydroxyapatite/collagen composites in the fixation of bone implants. The composites used in this study is produced by Institute of Science...

  8. Identification of Storm Surge Vulnerable Areas in the Philippines Through Simulations of Typhoon Haiyan-Induced Storm Surge Using Tracks of Historical Tropical Cyclones

    Science.gov (United States)

    Lapidez, John Phillip; Suarez, John Kenneth; Tablazon, Judd; Dasallas, Lea; Gonzalo, Lia Anne; Santiago, Joy; Cabacaba, Krichi May; Ramos, Michael Marie Angelo; Mahar Francisco Lagmay, Alfredo; Malano, Vicente

    2014-05-01

    Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR) 07 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the typhoon's storm surge and strong winds. Storm surges up to a height of 7 meters were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards, the flagship disaster mitigation program of the Department of Science and Technology, Government of the Philippines, to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948-2013. DOST-Project NOAH used the Japan Meteorological Agency (JMA) Storm Surge Model, a numerical code that simulates and predicts storm surges spawned by tropical cyclones. Input parameters for the storm surge model include bathymetric data, storm track, central atmospheric pressure, and maximum wind speed. The simulations were made using Haiyan's pressure and wind speed as the forcing parameters. The simulated storm surge height values were added to the maximum tide level obtained from WXTide, software that contains a catalogue of worldwide astronomical tides, to come up with storm tide levels. The resulting water level was used as input to FLO-2D to generate the storm tide inundation maps. One product of this study is a list of the most vulnerable coastal areas that can be used as basis for choosing priority sites for further studies to implement appropriate site-specific solutions. Another product is the storm tide inundation maps that the local government units can use to develop a Risk-Sensitive Land Use Plan for identifying appropriate areas to build residential buildings

  9. Life Estimation of Hip Joint Prosthesis

    Science.gov (United States)

    Desai, C.; Hirani, H.; Chawla, A.

    2015-07-01

    Hip joint is one of the largest weight-bearing structures in the human body. In the event of a failure of the natural hip joint, it is replaced with an artificial hip joint, known as hip joint prosthesis. The design of hip joint prosthesis must be such so as to resist fatigue failure of hip joint stem as well as bone cement, and minimize wear caused by sliding present between its head and socket. In the present paper an attempt is made to consider both fatigue and wear effects simultaneously in estimating functional-life of the hip joint prosthesis. The finite element modeling of hip joint prosthesis using HyperMesh™ (version 9) has been reported. The static analysis (load due to the dead weight of the body) and dynamic analysis (load due to walking cycle) have been described. Fatigue life is estimated by using the S-N curve of individual materials. To account for progressive wear of hip joint prosthesis, Archard's wear law, modifications in socket geometry and dynamic analysis have been used in a sequential manner. Using such sequential programming reduction in peak stress has been observed with increase in wear. Finally life is estimated on the basis of socket wear.

  10. Criteria for the Identification of Pyroclastic Surge Deposits on Mars: Insight from Hunt's Hole, New Mexico

    Science.gov (United States)

    Edgar, L. A.; Grotzinger, J. P.; Southard, J. B.; Ewing, R. C.; Lamb, M. P.

    2012-03-01

    We combine field observations, Terrestrial Laser Scanning (TLS), and hydrodynamic considerations to understand pyroclastic surge deposits at Hunt’s Hole, New Mexico, and provide criteria for their identification on Mars.

  11. Three-Dimensional Numerical Analysis of Compound Lining in Complex Underground Surge-Shaft Structure

    Directory of Open Access Journals (Sweden)

    Juntao Chen

    2015-01-01

    Full Text Available The mechanical behavior of lining structure of deep-embedded cylinder surge shaft with multifork tunnel is analyzed using three-dimensional nonlinear FEM. With the elastic-plastic constitutive relations of rock mass imported and the implicit bolt element and distributed concrete cracking model adopted, a computing method of complex surge shaft is presented for the simulation of underground excavations and concrete lining cracks. In order to reflect the interaction and initial gap between rock mass and concrete lining, a three-dimensional nonlinear interface element is adopted, which can take into account both the normal and tangential characteristics. By an actual engineering computation, the distortion characteristics and stress distribution rules of the dimensional multifork surge-shaft lining structure under different behavior are revealed. The results verify the rationality and feasibility of this computation model and method and provide a new idea and reference for the complex surge-shaft design and construction.

  12. ISSN 2073 ISSN 2073-9990 East Cent. Afr. J. surg. (Online) 9990 ...

    African Journals Online (AJOL)

    Prof Kakande

    Afr. J. surg. ..... September/October 2003. 3. Hardin R, Stevenson M, Downie W, Wilson G. Assessment of clinical competence using objective ... Michael J. Griesser, Matthew C. Beran, David C. Flanigan, Michael Quackenbush, DO, Corey Van ...

  13. Evaluation of Ferrite Chip Beads as Surge Current Limiters in Circuits with Tantalum Capacitors

    Science.gov (United States)

    Teverovsky, Alexander

    2014-01-01

    Limiting resistors are currently required to be connected in series with tantalum capacitors to reduce the risk of surge current failures. However, application of limiting resistors decreases substantially the efficiency of the power supply systems. An ideal surge current limiting device should have a negligible resistance for DC currents and high resistance at frequencies corresponding to transients in tantalum capacitors. This work evaluates the possibility of using chip ferrite beads (FB) as such devices. Twelve types of small size FBs from three manufacturers were used to evaluate their robustness under soldering stresses and at high surge current spikes associated with transients in tantalum capacitors. Results show that FBs are capable to withstand current pulses that are substantially greater than the specified current limits. However, due to a sharp decrease of impedance with current, FBs do not reduce surge currents to the required level that can be achieved with regular resistors.

  14. MAGNETIC-RECONNECTION GENERATED SHOCK WAVES AS A DRIVER OF SOLAR SURGES

    International Nuclear Information System (INIS)

    Yang, Heesu; Chae, Jongchul; Park, Hyungmin; Song, Dong-uk; Cho, Kyuhyoun; Lim, Eun-Kyung; Lee, Kyoung-sun

    2014-01-01

    We found that a surge consists of multiple shock features. In our high-spatiotemporal spectroscopic observation of the surge, each shock is identified with the sudden appearance of an absorption feature at the blue wings of the Ca II 8542 Å line and Hα line that gradually shifts to the red wings. The shock features overlap with one another with the time interval of 110 s, which is much shorter than the duration of each shock feature, 300-400 s. This finding suggests that the multiple shocks might not have originated from a train of sinusoidal waves generated by oscillations and flows in the photosphere. As we found the signature of the magnetic flux cancelations at the base of the surge, we conclude that the multiple shock waves in charge of the surge were generated by the magnetic reconnection that occurred in the low atmosphere in association with the flux cancelation

  15. Sea, Lake, and Overland Surge from Hurricanes (SLOSH) Inundation for Categories 2 and 4

    Data.gov (United States)

    U.S. Environmental Protection Agency — The file geodatabase (fgdb) contains the Sea, Lake, and Overland Surge from Hurricanes (SLOSH) Maximum of Maximums (MOM) model for hurricane categories 2 and 4. The...

  16. Control of Surge in Centrifugal Compressors by Active Magnetic Bearings Theory and Implementation

    CERN Document Server

    Yoon, Se Young; Allaire, Paul E

    2013-01-01

    Control of Surge in Centrifugal Compressors by Active Magnetic Bearings sets out the fundamentals of integrating the active magnetic bearing (AMB) rotor suspension technology in compressor systems, and describes how this relatively new bearing technology can be employed in the active control of compressor surge. The authors provide a self-contained and comprehensive review of rotordynamics and the fundamentals of the AMB technology. The active stabilization of compressor surge employing AMBs in a machine is fully explored, from the modeling of the instability and the design of feedback controllers, to the implementation and experimental testing of the control algorithms in a specially-constructed, industrial-size centrifugal compression system. The results of these tests demonstrate the great potential of the new surge control method developed in this text. This book will be useful for engineers in industries that involve turbocompressors and magnetic bearings, as well as for researchers and graduate students...

  17. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L

    2005-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  18. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L

    2004-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  19. Real-Time Forecasting System of Winds, Waves and Surge in Tropical Cyclones

    National Research Council Canada - National Science Library

    Graber, Hans C; Donelan, Mark A; Brown, Michael G; Slinn, Donald N; Hagen, Scott C; Thompson, Donald R; Jensen, Robert E; Black, Peter G; Powell, Mark D; Guiney, John L; Cardone, Vincent J; Cox, Andrew T; Augustus, Ellsworth H; Colonnese, Christopher P

    2003-01-01

    The long-term goal of this partnership is to establish an operational forecasting system of the wind field and resulting waves and surge impacting the coastline during the approach and landfall of tropical cyclones...

  20. 正骨手法结合正骨散外用治疗陈旧性踝关节扭伤的疗效观察%Bone-setting manipulation combined with Zhenggu powder treatment of chronic ankle joint sprain of curative effect observation

    Institute of Scientific and Technical Information of China (English)

    张红川; 王法利

    2014-01-01

    目的:探讨和分析应用正骨手法结合正骨散治疗陈旧性踝关节扭伤的疗效。方法自2011年6月~2012年5月,采用正骨手法结合正骨散外用治疗陈旧性踝关节共38例,男20例,女18例。年龄21~55岁,平均38岁,病程平均63天。按照Baird-Jackson踝关节评分,治疗3周后比较患者的治疗前后踝关节功能评分。结果38例患者治疗前Baird-Jackson踝关节评分为64.36±4.26,经手法结合正骨散治疗后评分为90.22±5.13,治疗前后存在显著性差异(P<0.01)。结论正骨手法结合正骨散外用是治疗陈旧性踝关节扭伤的一种有效的方法。%Abastract:ObjectiveTo discussion and analysis of the application of Bone-setting manipulation combined with Zhenggu powder in the treatment of chronic ankle joint sprain effect.Methods From 2011 June to 2012 May, with Bone-setting manipulation combined with Zhenggu powder for the treatment of chronic ankle in 38 cases, male 20 cases, female 18 cases. The age ranged from 21 to 55 years old, average 38 years old, average duration was 63 days. According to Baird-Jackson ankle function score, ankle joint function score were compared before and after treatment and 3 weeks after treatment. Results In 38 cases of patients before treatment ,Baird-Jackson ankle function score was 64.36 ± 4.26, by manipulation combined with Zhenggu powder after treatment was 90.22 ± 5.13 .Before and after treatment, there were significant differences(P<0.01). Conclusion Bone-setting manipulation combined with Zhenggu powder is an effective method for treatment of chronic ankle joint sprain.

  1. Study of a Novel Oscillating Surge Wave Energy Converter: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Tom, Nathan M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Choiniere, Michael [University of Maine; Thiagarajan, Krish P. [University of Maine

    2017-08-01

    This study investigates the performance of an oscillating surge wave energy converter (OSWEC) that utilizes adjustable geometry as a means of controlling the hydrodynamic coefficients, a concept originally proposed by [1]. The body of the device consists of a bottom-hinged solid rectangular frame with five horizontal flaps spanning the interior of the frame. The flaps can rotate independently about their center of rotation within the frame like a large window shutter. Changing the orientation of the flaps alters the hydrodynamic coefficients and natural frequency of the device as well as the ability to shed or absorb structural loads accordingly. This ability may allow the device to operate in a wider range of sea states than other current wave energy converter designs. This paper presents and compares the results of numerical simulations and experimental testing of the OSWEC's response to regular waves with all five of the horizontal fin configurations sharing the same orientation of 0 degrees (fully closed interior) and 90 degrees (fully open). The numerical simulations were performed using WAMIT, which calculates hydrodynamic coefficients using a boundary element method code to solve the linear potential flow problem, and WEC-Sim, a MATLAB-based tool that simulates multibody devices in the time domain by solving the governing equations of motion. A 1:14 scale model of the device was built for experimental evaluation in an 8-m-long, 1-m wide wave tank, which supports a water depth of 0.7 m. The OSWEC motion in different wave conditions was measured with displacement sensors while nonlinear wave-structure interaction effects like slamming and overtopping were captured using a high-speed camera and used to understand differences between the simulation and experiments.

  2. Reference Model 5 (RM5): Oscillating Surge Wave Energy Converter

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Y. H. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jenne, D. S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Thresher, R. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Copping, A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Geerlofs, S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hanna, L. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-01-01

    This report is an addendum to SAND2013-9040: Methodology for Design and Economic Analysis of Marine Energy Conversion (MEC) Technologies. This report describes an Oscillating Water Column Wave Energy Converter (OSWEC) reference model design in a complementary manner to Reference Models 1-4 contained in the above report. A conceptual design for a taut moored oscillating surge wave energy converter was developed. The design had an annual electrical power of 108 kilowatts (kW), rated power of 360 kW, and intended deployment at water depths between 50 m and 100 m. The study includes structural analysis, power output estimation, a hydraulic power conversion chain system, and mooring designs. The results were used to estimate device capital cost and annual operation and maintenance costs. The device performance and costs were used for the economic analysis, following the methodology presented in SAND2013-9040 that included costs for designing, manufacturing, deploying, and operating commercial-scale MEC arrays up to 100 devices. The levelized cost of energy estimated for the Reference Model 5 OSWEC, presented in this report, was for a single device and arrays of 10, 50, and 100 units, and it enabled the economic analysis to account for cost reductions associated with economies of scale. The baseline commercial levelized cost of energy estimate for the Reference Model 5 device in an array comprised of 10 units is $1.44/kilowatt-hour (kWh), and the value drops to approximately $0.69/kWh for an array of 100 units.

  3. [Temporo-mandibular joint. Morpho-functional considerations].

    Science.gov (United States)

    Scutariu, M D; Indrei, Anca

    2004-01-01

    The temporo-mandibular joint is distinguished from most other synovial joints of the body by two features: 1. the two jointed components carry teeth whose position and occlusion introduce a very strong influence on the movements of the temporo-mandibular joint and 2. its articular surfaces are not covered by hyaline cartilage, but by a dense, fibrous tissue. This paper describes the parts of the temporo-mandibular joint: the articular surfaces (the condylar process of the mandible and the glenoid part of the temporal bone), the fibrocartilaginous disc which is interposed between the mandibular and the temporal surface, the fibrous capsule of the temporo-mandibular joint and the ligaments of this joint. All these parts present a very strong adaptation at the important functions of the temporo-mandibular joint.

  4. Data Assimilation within the Advanced Circulation (ADCIRC) Modeling Framework for Hurricane Storm Surge Forecasting

    KAUST Repository

    Butler, T.

    2012-07-01

    Accurate, real-time forecasting of coastal inundation due to hurricanes and tropical storms is a challenging computational problem requiring high-fidelity forward models of currents and water levels driven by hurricane-force winds. Despite best efforts in computational modeling there will always be uncertainty in storm surge forecasts. In recent years, there has been significant instrumentation located along the coastal United States for the purpose of collecting data—specifically wind, water levels, and wave heights—during these extreme events. This type of data, if available in real time, could be used in a data assimilation framework to improve hurricane storm surge forecasts. In this paper a data assimilation methodology for storm surge forecasting based on the use of ensemble Kalman filters and the advanced circulation (ADCIRC) storm surge model is described. The singular evolutive interpolated Kalman (SEIK) filter has been shown to be effective at producing accurate results for ocean models using small ensemble sizes initialized by an empirical orthogonal function analysis. The SEIK filter is applied to the ADCIRC model to improve storm surge forecasting, particularly in capturing maximum water levels (high water marks) and the timing of the surge. Two test cases of data obtained from hindcast studies of Hurricanes Ike and Katrina are presented. It is shown that a modified SEIK filter with an inflation factor improves the accuracy of coarse-resolution forecasts of storm surge resulting from hurricanes. Furthermore, the SEIK filter requires only modest computational resources to obtain more accurate forecasts of storm surge in a constrained time window where forecasters must interact with emergency responders.

  5. Alternate Care Sites for the Management of Medical Surge in Disasters

    Science.gov (United States)

    2013-12-01

    care facilities are in place  Plan for community based surge hospital bed surge capacity is in place  A 50-bed nursing subunit—per 50,000...attempt to assess the preparedness of the hospital system, HHS/ASPR commissioned The Center for Biosecurity of UPMC to examine various responses to...catastrophic health efforts. The 11 report The Next Challenge in Healthcare Preparedness: Catastrophic Health Events (Center for Biosecurity of UPMC

  6. Radiological analyses of France Telecom surge arresters. Study performed for the CGT FAPT Cantal

    International Nuclear Information System (INIS)

    2010-02-01

    This document reports the radiological characterization of various versions of surge arresters used in the past to protect telephone lines against over-voltages. These equipment, which use various radioactive materials, were assessed by gamma radiation flow measurements, alpha-beta-gamma count rate measurements, dose rate measurements, gamma spectrometry analyses, tritium emanation test, radon 222 emanation test, smearing. Recommendations are formulated to manage radioactive surge arresters which are still being operated

  7. The Effect of Coastal Development on Storm Surge Flooding in Biscayne Bay, Florida, USA (Invited)

    Science.gov (United States)

    Zhang, K.; Liu, H.; Li, Y.

    2013-12-01

    Barrier islands and associated bays along the Atlantic and Gulf Coasts are a favorite place for both living and visiting. Many of them are vulnerable to storm surge flooding because of low elevations and constantly being subjected to the impacts of storms. The population increase and urban development along the barrier coast have altered the shoreline configuration, resulting in a dramatic change in the coastal flooding pattern in some areas. Here we present such a case based on numerical simulations of storm surge flooding caused by the1926 hurricane in the densely populated area surrounding Biscayne Bay in Miami, Florida. The construction of harbor and navigation channels, and the development of real estate and the roads connecting islands along Biscayne Bay have changed the geometry of Biscayne Bay since 1910s. Storm surge simulations show that the Port of Miami and Dodge Island constructed by human after 1950 play an important role in changing storm surge inundation pattern along Biscayne Bay. Dodge Island enhances storm surge and increases inundation in the area south of the island, especially at the mouth of Miami River (Downtown of Miami), and reduces storm surge flooding in the area north of the island, especially in Miami Beach. If the Hurricane Miami of 1926 happened today, the flooding area would be reduced by 55% and 20% in the Miami Beach and North Miami areas, respectively. Consequently, it would prevent 400 million of property and 10 thousand people from surge flooding according to 2010 U.S census and 2007 property tax data. Meanwhile, storm water would penetrate further inland south of Dodge Island and increase the flooding area by 25% in the Miami River and Downtown Miami areas. As a result, 200 million of property and five thousand people would be impacted by storm surge.

  8. Bone healing and bone substitutes.

    Science.gov (United States)

    Costantino, Peter D; Hiltzik, David; Govindaraj, Satish; Moche, Jason

    2002-02-01

    With the advent of new biomaterials and surgical techniques, the reconstructive surgeon has a wider range of treatment modalities for the rehabilitation and reconstruction of craniofacial skeletal deformities than ever before. These innovative substances act as true bone graft substitutes, thereby allowing the surgeon to avoid the use of autogenous bone grafts and their associated donor site morbidity. Surgeons have long been interested in producing a composite graft that can heal faster by induction, incorporate with surrounding tissues, and be remodeled to resemble native bone. Currently, there are a host of bone graft substitutes available that vary in both their composition and properties. Craniomaxillofacial surgeons must therefore become comfortable with numerous biomaterials to best tailor the treatment for each patient individually. Ongoing investigations into the next phase of tissue engineering will continue to bring us closer to the ability to regenerate or replace bone.

  9. Storm surge evolution and its relationship to climate oscillations at Duck, NC

    Science.gov (United States)

    Munroe, Robert; Curtis, Scott

    2017-07-01

    Coastal communities experience increased vulnerability during storm surge events through the risk of damage to coastal infrastructure, erosion/deposition, and the endangerment of human life. Policy and planning measures attempt to avoid or mitigate storm surge consequences through building codes and setbacks, beach stabilization, insurance rates, and coastal zoning. The coastal emergency management community and public react and respond on shorter time scales, through temporary protection, emergency stockpiling, and evacuation. This study utilizes time series analysis, the Kolmogorov-Smirnov (K-S) test, Pearson's correlation, and the generalized extreme value (GEV) theorem to make the connection between climate oscillation indices and storm surge characteristics intra-seasonally to inter-annually. Results indicate that an El Niño (+ENSO), negative phase of the NAO, and positive phase of the PNA pattern all support longer duration and hence more powerful surge events, especially in winter. Increased surge duration increases the likelihood of extensive erosion, inland inundation, among other undesirable effects of the surge hazard.

  10. The value of wetlands in protecting southeast louisiana from hurricane storm surges.

    Science.gov (United States)

    Barbier, Edward B; Georgiou, Ioannis Y; Enchelmeyer, Brian; Reed, Denise J

    2013-01-01

    The Indian Ocean tsunami in 2004 and Hurricanes Katrina and Rita in 2005 have spurred global interest in the role of coastal wetlands and vegetation in reducing storm surge and flood damages. Evidence that coastal wetlands reduce storm surge and attenuate waves is often cited in support of restoring Gulf Coast wetlands to protect coastal communities and property from hurricane damage. Yet interdisciplinary studies combining hydrodynamic and economic analysis to explore this relationship for temperate marshes in the Gulf are lacking. By combining hydrodynamic analysis of simulated hurricane storm surges and economic valuation of expected property damages, we show that the presence of coastal marshes and their vegetation has a demonstrable effect on reducing storm surge levels, thus generating significant values in terms of protecting property in southeast Louisiana. Simulations for four storms along a sea to land transect show that surge levels decline with wetland continuity and vegetation roughness. Regressions confirm that wetland continuity and vegetation along the transect are effective in reducing storm surge levels. A 0.1 increase in wetland continuity per meter reduces property damages for the average affected area analyzed in southeast Louisiana, which includes New Orleans, by $99-$133, and a 0.001 increase in vegetation roughness decreases damages by $24-$43. These reduced damages are equivalent to saving 3 to 5 and 1 to 2 properties per storm for the average area, respectively.

  11. Cortisol Interferes with the Estradiol-Induced Surge of Luteinizing Hormone in the Ewe1

    Science.gov (United States)

    Wagenmaker, Elizabeth R.; Breen, Kellie M.; Oakley, Amy E.; Pierce, Bree N.; Tilbrook, Alan J.; Turner, Anne I.; Karsch, Fred J.

    2008-01-01

    Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep were treated sequentially with progesterone and estradiol to create artificial estrous cycles. Cortisol or vehicle (saline) was infused from 2 h before the estradiol stimulus through the time of the anticipated LH surge in the artificial follicular phase of two successive cycles. The plasma cortisol increment produced by infusion was ∼1.5 times greater than maximal concentrations seen during infusion of endotoxin, which is a model of immune/inflammatory stress. In experiment 1, half of the ewes received vehicle in the first cycle and cortisol in the second; the others were treated in reverse order. All ewes responded with an LH surge. Cortisol delayed the LH surge and reduced its amplitude, but both effects were observed only in the second cycle. Experiment 2 was modified to provide better control for a cycle effect. Four treatment sequences were tested (cycle 1-cycle 2): vehicle-vehicle, cortisol-cortisol, vehicle-cortisol, cortisol-vehicle. Again, cortisol delayed but did not block the LH surge, and this delay occurred in both cycles. Thus, an elevation in plasma cortisol can interfere with the positive feedback action of estradiol by delaying and attenuating the LH surge. PMID:19056703

  12. Probabilistic hurricane-induced storm surge hazard assessment in Guadeloupe, Lesser Antilles

    Science.gov (United States)

    Krien, Y.; Dudon, B.; Roger, J.; Zahibo, N.

    2015-08-01

    Current storm surge hazard maps in the French West Indies are essentially based on simple statistical methods using limited historical data and early low-resolution models which do not take the effect of waves into account. In this paper, we infer new 100-year and 1000-year surge levels in Guadeloupe from the numerical modelling of storm surges induced by a large set of synthetic events that are in statistical agreement with features of historical hurricanes in the North Atlantic Basin between 1980 and 2011. Computations are performed using the wave-current coupled model ADCIRC-SWAN with high grid resolutions (up to 40-60 m) in the coastal and wave dissipation areas. This model is validated against observations during past events such as hurricane HUGO (1989). Results are generally found to be in reasonable agreement with past studies in areas where surge is essentially wind-driven, but found to differ significantly in coastal regions where the transfer of momentum from waves to the water column constitutes a non-negligible part of the total surge. The methodology, which can be applied to other islands in the Lesser Antilles, allows storm surge level maps to be obtained that can be of major interest for coastal planners and decision makers in terms of risk management.

  13. Modeling Flood Inundation Induced by River Flow and Storm Surges over a River Basin

    Directory of Open Access Journals (Sweden)

    Wei-Bo Chen

    2014-10-01

    Full Text Available Low-lying coastal regions and their populations are at risk during storm surge events and high freshwater discharges from upriver. An integrated storm surge and flood inundation modeling system was used to simulate storm surge and inundation in the Tsengwen River basin and the adjacent coastal area in southern Taiwan. A three-dimensional hydrodynamic model with an unstructured grid was used, which was driven by the tidal elevation at the open boundaries and freshwater discharge at the upriver boundary. The model was validated against the observed water levels for three typhoon events. The simulation results for the model were in reasonable agreement with the observational data. The model was then applied to investigate the effects of a storm surge, freshwater discharge, and a storm surge combined with freshwater discharge during an extreme typhoon event. The super Typhoon Haiyan (2013 was artificially shifted to hit Taiwan: the modeling results showed that the inundation area and depth would cause severe overbank flow and coastal flooding for a 200 year return period flow. A high-resolution grid model is essential for the accurate simulation of storm surges and inundation.

  14. Fluid-structure interaction analysis for pressurizer surge line subjected to thermal stratification

    International Nuclear Information System (INIS)

    Kang, Dong Gu; Jhung, Myung Jo; Chang, Soon Heung

    2011-01-01

    Research highlights: → Temperature of surge line due to stratified flow is defined using CFD analysis. → Fluid-structure interaction analysis is performed to investigate the response characteristics due to thermal stress. → Fatigue usage factors due to thermal stratification are relatively low. → Simplifying temperature distribution in surge line is not always conservative. - Abstract: Serious mechanical damages such as cracks and plastic deformations due to excessive thermal stress caused by thermal stratification have been experienced in several nuclear power plants. In particular, the thermal stratification in the pressurizer surge line has been addressed as one of the significant safety and technical issues. In this study, a detailed unsteady computational fluid dynamics (CFD) analysis involving conjugate heat transfer analysis is performed to obtain the transient temperature distributions in the wall of the pressurizer surge line subjected to stratified internal flows either during out-surge or in-surge operation. The thermal loads from CFD calculations are transferred to the structural analysis code which is employed for the thermal stress analysis to investigate the response characteristics, and the fatigue analysis is ultimately performed. In addition, the thermal stress and fatigue analysis results obtained by applying the realistic temperature distributions from CFD calculations are compared with those by assuming the simplified temperature distributions to identify some requirements for a realistic and conservative thermal stress analysis from a safety point of view.

  15. The insulation coordination and surge arrester design for HTS cable system in Icheon substation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hansang, E-mail: Hansang80@korea.ac.kr [School of Railway and Electrical Engineering, Kyungil University, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 712-701 (Korea, Republic of); Yoon, Dong-Hee [Department of New and Renewable Energy, Kyungil University, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 712-701 (Korea, Republic of); Lee, Seung-Ryul [Korea Electrotechnology Research Institute, Naeson-dong, Uiwang-si, Gyeonggi-do 437-080 (Korea, Republic of); Yang, Byeong-Mo [Korea Electric Power Research Institute, Munji-dong, Yuseong-gu, Daejeon 305-760 (Korea, Republic of); Jang, Gilsoo, E-mail: gjang@korea.ac.kr [School of Electrical Engineering, Korea University, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-713 (Korea, Republic of)

    2013-01-15

    Highlights: ► It is necessary to study lightning response of the HTS cable. ► The analytic model has been developed for the HTS cable in the Icheon substation. ► Well-designed surge arrester has been verified through PSCAD/EMTDC simulations. -- Abstract: This paper proposes an insulation coordination and surge arrester design for HTS (High-Temperature Superconducting) cable system in Icheon substation in Korea. In the aspect of the economic analysis, since the HTS cable is very expensive, the insulation coordination to prevent the dielectric breakdown caused by the lightning surge should be considered carefully. Also, in the aspect of the power system reliability, since the HTS cable has much more capacity compared than conventional power cables and the ripple effect from the HTS cable failure may lead to the wide area blackout, an intensive study for insulation coordination from lightning surge is one of the most important considerations. In this paper, the insulation coordination for lightning surge is verified using HTS cable and power equipment models and the design of the proper surge arrester is proposed.

  16. Effect of Hydraulic Accumulator on Pressure Surge of a Hydrostatic Transmission System

    Science.gov (United States)

    Kumar, Ajit; Das, Jayanta; Dasgupta, Kabir; Barnwal, Manish Kumar

    2018-04-01

    Hydraulic power system is generally used in off-road vehicles for power transmission such as Heavy Earth Moving Machineries (HEMM). Their energy efficiency and unsubstantial failure becomes an extensive subject of analysis. Various arrangements in the system are compassed along with the utilization of some appropriate components. Application of a hydraulic accumulator is one among them. Benefits of accumulator is its multi-purpose usages like energy saving and pressure surge damping. This paper deals with the control of pressure surges in the hydraulic system and energy saving from the surges by using accumulator. For this purpose, the simulation of the hydraulic system is done in MATLAB/SimulinkR environment and an external disturbance is introduced to generate the pressure surge. The surge absorptivity of the accumulator is studied for different sizes at different pre-charged conditions of the accumulator. The discharge characteristics of different sized accumulators are also analyzed in this paper. It is observed that the ability to absorb the surge and stabilize the system is high in the smaller capacity accumulator. However the energy delivery time of larger sized accumulator is high.

  17. Modeling and simulation of storm surge on Staten Island to understand inundation mitigation strategies

    Science.gov (United States)

    Kress, Michael E.; Benimoff, Alan I.; Fritz, William J.; Thatcher, Cindy A.; Blanton, Brian O.; Dzedzits, Eugene

    2016-01-01

    Hurricane Sandy made landfall on October 29, 2012, near Brigantine, New Jersey, and had a transformative impact on Staten Island and the New York Metropolitan area. Of the 43 New York City fatalities, 23 occurred on Staten Island. The borough, with a population of approximately 500,000, experienced some of the most devastating impacts of the storm. Since Hurricane Sandy, protective dunes have been constructed on the southeast shore of Staten Island. ADCIRC+SWAN model simulations run on The City University of New York's Cray XE6M, housed at the College of Staten Island, using updated topographic data show that the coast of Staten Island is still susceptible to tidal surge similar to those generated by Hurricane Sandy. Sandy hindcast simulations of storm surges focusing on Staten Island are in good agreement with observed storm tide measurements. Model results calculated from fine-scaled and coarse-scaled computational grids demonstrate that finer grids better resolve small differences in the topography of critical hydraulic control structures, which affect storm surge inundation levels. The storm surge simulations, based on post-storm topography obtained from high-resolution lidar, provide much-needed information to understand Staten Island's changing vulnerability to storm surge inundation. The results of fine-scale storm surge simulations can be used to inform efforts to improve resiliency to future storms. For example, protective barriers contain planned gaps in the dunes to provide for beach access that may inadvertently increase the vulnerability of the area.

  18. Three-dimensional geometric analysis of felid limb bone allometry.

    Directory of Open Access Journals (Sweden)

    Michael Doube

    Full Text Available Studies of bone allometry typically use simple measurements taken in a small number of locations per bone; often the midshaft diameter or joint surface area is compared to body mass or bone length. However, bones must fulfil multiple roles simultaneously with minimum cost to the animal while meeting the structural requirements imposed by behaviour and locomotion, and not exceeding its capacity for adaptation and repair. We use entire bone volumes from the forelimbs and hindlimbs of Felidae (cats to investigate regional complexities in bone allometry.Computed tomographic (CT images (16435 slices in 116 stacks were made of 9 limb bones from each of 13 individuals of 9 feline species ranging in size from domestic cat (Felis catus to tiger (Panthera tigris. Eleven geometric parameters were calculated for every CT slice and scaling exponents calculated at 5% increments along the entire length of each bone. Three-dimensional moments of inertia were calculated for each bone volume, and spherical radii were measured in the glenoid cavity, humeral head and femoral head. Allometry of the midshaft, moments of inertia and joint radii were determined. Allometry was highly variable and related to local bone function, with joint surfaces and muscle attachment sites generally showing stronger positive allometry than the midshaft.Examining whole bones revealed that bone allometry is strongly affected by regional variations in bone function, presumably through mechanical effects on bone modelling. Bone's phenotypic plasticity may be an advantage during rapid evolutionary divergence by allowing exploitation of the full size range that a morphotype can occupy. Felids show bone allometry rather than postural change across their size range, unlike similar-sized animals.

  19. Identification of storm surge vulnerable areas in the Philippines through the simulation of Typhoon Haiyan-induced storm surge levels over historical storm tracks

    Science.gov (United States)

    Lapidez, J. P.; Tablazon, J.; Dasallas, L.; Gonzalo, L. A.; Cabacaba, K. M.; Ramos, M. M. A.; Suarez, J. K.; Santiago, J.; Lagmay, A. M. F.; Malano, V.

    2015-07-01

    Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR) on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH) which is the flagship disaster mitigation program of the Department of Science and Technology (DOST) of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948-2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

  20. Identification of storm surge vulnerable areas in the Philippines through the simulation of Typhoon Haiyan-induced storm surge levels over historical storm tracks

    Directory of Open Access Journals (Sweden)

    J. P. Lapidez

    2015-07-01

    Full Text Available Super Typhoon Haiyan entered the Philippine Area of Responsibility (PAR on 7 November 2013, causing tremendous damage to infrastructure and loss of lives mainly due to the storm surge and strong winds. Storm surges up to a height of 7 m were reported in the hardest hit areas. The threat imposed by this kind of natural calamity compelled researchers of the Nationwide Operational Assessment of Hazards (Project NOAH which is the flagship disaster mitigation program of the Department of Science and Technology (DOST of the Philippine government to undertake a study to determine the vulnerability of all Philippine coastal communities to storm surges of the same magnitude as those generated by Haiyan. This study calculates the maximum probable storm surge height for every coastal locality by running simulations of Haiyan-type conditions but with tracks of tropical cyclones that entered PAR from 1948–2013. One product of this study is a list of the 30 most vulnerable coastal areas that can be used as a basis for choosing priority sites for further studies to implement appropriate site-specific solutions for flood risk management. Another product is the storm tide inundation maps that the local government units can use to develop a risk-sensitive land use plan for identifying appropriate areas to build residential buildings, evacuation sites, and other critical facilities and lifelines. The maps can also be used to develop a disaster response plan and evacuation scheme.

  1. Expression of CGRP in the temporomandibular joint

    International Nuclear Information System (INIS)

    Caviedes Bucheli, Javier; Medina Buitrago, Diana Marcela

    2002-01-01

    The presence and content of calcitonin gene-related peptide (CGRP) is evaluated in the hyperplastic retrodiscal tissue of the temporomandibular joint in patients with joint degenerative disease by radioimmunoassay. Study population has included 8 female patients in pre-menopausic status, without to be pregnant, without to be lactating for a year and with diagnostic of joint degenerative disease (osteoarthrosis). Pain levels are registered with visual analog scale, where 0 is absence of pain and 16 acute pain. A bone degeneration is classified as mild, moderate and severe, according to findings of nuclear magnetic resonance. The 15 retrodiscal hyperplastic tissue samples are taken from patients undergoing to open surgery of temporomandibular joint. The specimens were placed in plastic blocks with freezing medium and are stored at -70 degrees celsius until neuropeptide extraction by radioimmunoassay with kit for CGRP. A directly proportional relationship is established between the degree of bone degeneration and neuropeptide expression and between the osteoarthrosis classification with analogue visual scale. Findings have shown definitive correlation between pain levels and expression of neuropeptide. CGRP is expressed in the retrodiscal tissue of temporomandibular joint in human with joint degenerative disease and is directly related with levels osteoarthrosis and pain [es

  2. Can symptomatic acromioclavicular joints be differentiated from asymptomatic acromioclavicular joints on 3-T MR imaging?

    Science.gov (United States)

    Choo, Hye Jung; Lee, Sun Joo; Kim, Jung Han; Cha, Seong Sook; Park, Young Mi; Park, Ji Sung; Lee, Jun Woo; Oh, Minkyung

    2013-04-01

    To evaluate retrospectively whether symptomatic acromioclavicular joints can be differentiated from asymptomatic acromioclavicular joints on 3-T MR imaging. This study included 146 patients who underwent physical examination of acromioclavicular joints and 3-T MR imaging of the shoulder. Among them, 67 patients showing positive results on physical examination were assigned to the symptomatic group, whereas 79 showing negative results were assigned to the asymptomatic group. The following MR findings were compared between the symptomatic and asymptomatic groups: presence of osteophytes, articular surface irregularity, subchondral cysts, acromioclavicular joint fluid, subacromial fluid, subacromial bony spurs, joint capsular distension, bone edema, intraarticular enhancement, periarticular enhancement, superior and inferior joint capsular distension degree, and joint capsular thickness. The patients were subsequently divided into groups based on age (younger, older) and the method of MR arthrography (direct MR arthrography, indirect MR arthrography), and all the MR findings in each subgroup were reanalyzed. The meaningful cutoff value of each significant continuous variable was calculated using receiver operating characteristic analysis. The degree of superior capsular distension was the only significant MR finding of symptomatic acromioclavicular joints and its meaningful cutoff value was 2.1mm. After subgroup analyses, this variable was significant in the older age group and indirect MR arthrography group. On 3-T MR imaging, the degree of superior joint capsular distension might be a predictable MR finding in the diagnosis of symptomatic acromioclavicular joints. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Bone Biopsy

    Science.gov (United States)

    ... several inches long with a hollow core to capture the bone specimen. The CT scanner is typically ... IV), ultrasound machine and devices that monitor your heart beat and blood pressure. top of page How ...

  4. Bone pain

    DEFF Research Database (Denmark)

    Frost, Charlotte Ørsted; Hansen, Rikke Rie; Heegaard, Anne-Marie

    2016-01-01

    Skeletal conditions are common causes of chronic pain and there is an unmet medical need for improved treatment options. Bone pain is currently managed with disease modifying agents and/or analgesics depending on the condition. Disease modifying agents affect the underlying pathophysiology...... of the disease and reduce as a secondary effect bone pain. Antiresorptive and anabolic agents, such as bisphosphonates and intermittent parathyroid hormone (1-34), respectively, have proven effective as pain relieving agents. Cathepsin K inhibitors and anti-sclerostin antibodies hold, due to their disease...... modifying effects, promise of a pain relieving effect. NSAIDs and opioids are widely employed in the treatment of bone pain. However, recent preclinical findings demonstrating a unique neuronal innervation of bone tissue and sprouting of sensory nerve fibers open for new treatment possibilities....

  5. Bone sarcomas

    International Nuclear Information System (INIS)

    Mudry, P.

    2008-01-01

    Bone sarcomas are malignancies with peak incidence in adolescents and young adults. The most frequent are osteosarcoma and Ewing sarcoma/PNET, in an older adults are seen chondrosarcomas, other ones are rare. In general, biology of sarcomas is closely related to pediatric malignancies with fast growth, local aggressiveness, tendency to early hematogenic dissemination and chemo sensitivity. Diagnostics and treatment of bone sarcomas should be done in well experienced centres due to low incidence and broad issue of this topic. An interdisciplinary approach and staff education is essential in due care of patients with bone sarcoma. If these criteria are achieved, the cure rate is contemporary at 65 - 70 %, while some subpopulation of patients has chance for cure up to 90 %. Osteosarcoma and Ewing sarcoma/PNET are discussed below as types of most frequent bone sarcoma. (author)

  6. Paget's Disease of Bone and Osteoarthritis: Different Yet Related

    Science.gov (United States)

    ... a condition that causes changes in cartilage, the elastic tissue that cushions the joints. Healthy cartilage allows bones to glide over one another, while absorbing energy from the shock of physical movement. In osteoarthritis, the surface layer ...

  7. Selection of gonadotrophin surge attenuating factor phage antibodies by bioassay.

    Science.gov (United States)

    Sorsa-Leslie, Tarja; Mason, Helen D; Harris, William J; Fowler, Paul A

    2005-09-26

    We aimed to combine the generation of "artificial" antibodies with a rat pituitary bioassay as a new strategy to overcome 20 years of difficulties in the purification of gonadotrophin surge-attenuating factor (GnSAF). A synthetic single-chain antibody (Tomlinson J) phage display library was bio-panned with partially purified GnSAF produced by cultured human granulosa/luteal cells. The initial screening with a simple binding immunoassay resulted in 8 clones that were further screened using our in-vitro rat monolayer bioassay for GnSAF. Initially the antibodies were screened as pooled phage forms and subsequently as individual, soluble, single-chain antibody (scAbs) forms. Then, in order to improve the stability of the scAbs for immunopurification purposes, and to widen the range of labelled secondary antibodies available, these were engineered into full-length human immunoglobulins. The immunoglobulin with the highest affinity for GnSAF and a previously described rat anti-GnSAF polyclonal antiserum was then used to immunopurify bioactive GnSAF protein. The two purified preparations were electrophoresed on 1-D gels and on 7 cm 2-D gels (pH 4-7). The candidate GnSAF protein bands and spots were then excised for peptide mass mapping. Three of the scAbs recognised GnSAF bioactivity and subsequently one clone of the purified scAb-derived immunoglobulin demonstrated high affinity for GnSAF bioactivity, also binding the molecule in such as way as to block its bioactivity. When used for repeated immunopurification cycles and then Western blot, this antibody enabled the isolation of a GnSAF-bioactive protein band at around 66 kDa. Similar results were achieved using the rat anti-GnSAF polyclonal antiserum. The main candidate molecules identified from the immunopurified material by excision of 2-D gel protein spots was human serum albumin precursor and variants. This study demonstrates that the combination of bioassay and phage display technologies is a powerful tool in the

  8. Development of Low Surge Vacuum Contact with Te

    Energy Technology Data Exchange (ETDEWEB)

    Kim, B. S.; Lee, H. W.; Woo, B. C.; Kim, B. G. [Korea Electrotechnology Research Institute, Changwon (Korea, Republic of)

    1996-12-01

    The purpose of this study is to develop of low surge Te contact for vacuum circuit breaker. The vacuum circuit breaker have various advantages such that it is free from maintenance, does not bring about public pollution, is excellent in its current breaking property, and so forth, on account of which the extent of its application has become broadened rapidly. For the characteristics of the contact material for the vacuum circuit breaker to satisfy, there may be enumerated: (1)large current breaking capacity; (2)high voltage withstand; (3)small contact resistance; (4)small melt-adhesive force; (5)low chopping current value; (6)good workability; (7)sufficient mechanical strength; and so forth. In this study we used cobalt for based refractory material having high melting temperature and intermetallic material between tellurium and silver to reduce chopping current. The contact materials were produced in accordance with the powder metallurgy using the method of infiltration. Production of the contact material was carried out in such a method that cobalt powder having average particle size of 50{mu}m, pre sintered in H{sub 2} atmosphere, 900 degree C , 2 hour. Ag ingot and Te(Se) were alloyed using high frequency furnaced in vacuum. And then Ag-Te(Se) alloy was infiltrated to Co skeleton in H{sub 2} atmosphere, 1000 degree C , 1 hour. The melting of the alloy to be infiltrated was carried out in a vacuum sealed quartz tube and be analysed by X-ray diffraction, scanning electron microscope, optical microscope and energy dispersive energy spectrometer. In the alloying of silver and tellurium, tellurium does not exist in single element but Ag{sub 2}Te intermetallic compound. And In Ag and Se, Se does not exist in single element but Ag{sub 2}Se intermetallic compound. We also produced the test vacuum interruptor to evaluate the electrode properties in vacuum atmosphere. The electrical properties of Co-(Ag-Se) electrode have better value than that of Co-(Ag-Te) electrode

  9. Question mark ears, temporo-mandibular joint malformation and hypotonia: auriculo-condylar syndrome or a distinct entity?

    Science.gov (United States)

    Priolo, M; Lerone, M; Rosaia, L; Calcagno, E P; Sadeghi, A K; Ghezzi, F; Ravazzolo, R; Silengo, M

    2000-10-01

    We report a boy with prominent, peculiarly malformed ears, abnormality of the ramus of the mandible and hypotonia. An isolated peculiar bilateral ear deformity named 'question mark ear' has been delineated in plastic reconstruction surgery reviews [Cosman et al., 1970 Plast Reconstr Surg 46:454-457; Cosman (1984) Plast Reconstr Surg 73:572-576; Takato et al. (1989) Ann Plast Surg 22:69-73; Brodovsky (1997) Plast Reconstr Surg 100:1254-1257; Park (1998) Plast Reconstr Surg 101:1620-1623; Al-Quattan (1998) Plast Reconstr Surg 102:439-441] and a similar deformity of the ear and changes in the temporo-mandibular joint and condyle has been described by Jampol et al. [(1998) Am J Med Genet 75:449-452] and by Guion-Almeida et al. [(1999) Am J Med Genet 86:130-133]. The present case may be the third description of this malformation complex with additional clinical features characterized by hypotonia and mild developmental delay, or possibly a new distinct entity.

  10. Combined bilateral idiopathic necrosis of the humerus and femur heads: Bone scan, X-ray, CT, and MRI findings

    International Nuclear Information System (INIS)

    Piepenburg, R.; Hahn, K.; Doll, G.; Grimm, J.

    1992-01-01

    Untreated aseptic bone necroses close to a joint commonly leads to severe secondary arthrosis and destruction of the joint within a short time. Therefore, only a diagnosis in an early stage of the disease offers the chance of a successful joint- preserving therapy. In cases of clinically suspected aseptic bone necrosis but still negative or doubtful X-ray findings, bone scans or MRI are reliable methods of verifying the diagnosis. (orig./MG) [de

  11. Runoff-generated debris flows: observations and modeling of surge initiation, magnitude, and frequency

    Science.gov (United States)

    Kean, Jason W.; McCoy, Scott W.; Tucker, Gregory E.; Staley, Dennis M.; Coe, Jeffrey A.

    2013-01-01

    Runoff during intense rainstorms plays a major role in generating debris flows in many alpine areas and burned steeplands. Yet compared to debris flow initiation from shallow landslides, the mechanics by which runoff generates a debris flow are less understood. To better understand debris flow initiation by surface water runoff, we monitored flow stage and rainfall associated with debris flows in the headwaters of two small catchments: a bedrock-dominated alpine basin in central Colorado (0.06 km2) and a recently burned area in southern California (0.01 km2). We also obtained video footage of debris flow initiation and flow dynamics from three cameras at the Colorado site. Stage observations at both sites display distinct patterns in debris flow surge characteristics relative to rainfall intensity (I). We observe small, quasiperiodic surges at low I; large, quasiperiodic surges at intermediate I; and a single large surge followed by small-amplitude fluctuations about a more steady high flow at high I. Video observations of surge formation lead us to the hypothesis that these flow patterns are controlled by upstream variations in channel slope, in which low-gradient sections act as “sediment capacitors,” temporarily storing incoming bed load transported by water flow and periodically releasing the accumulated sediment as a debris flow surge. To explore this hypothesis, we develop a simple one-dimensional morphodynamic model of a sediment capacitor that consists of a system of coupled equations for water flow, bed load transport, slope stability, and mass flow. This model reproduces the essential patterns in surge magnitude and frequency with rainfall intensity observed at the two field sites and provides a new framework for predicting the runoff threshold for debris flow initiation in a burned or alpine setting.

  12. Joint Instability and Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Darryl Blalock

    2015-01-01

    Full Text Available Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA. Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  13. Joint instability and osteoarthritis.

    Science.gov (United States)

    Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

    2015-01-01

    Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  14. Bone--bone marrow interactions

    International Nuclear Information System (INIS)

    Patt, H.M.

    1976-01-01

    Within medullary cavities, blood formation tends to be concentrated near bone surfaces and this raises interesting questions about hematopoietic consequences of radionuclide fixation in osseous tissue. Thus, it may be important, on the one hand, to consider the medullary radiation dose distribution as well as total marrow dose from bone-bound radioelements and, on the other, to inquire about possible hematopoietic implications of radiation damage to endosteal surfaces per se. The reasons for this are discussed

  15. Avascular Necrosis of Bone after Renal Transplantation - Prevalence and Usefulness of Bone SPECT -

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yun Young; Yang, Seoung Oh; Ryuu, Jin Sook; Moon, Dae Hyuk; Lee, Hee Kyung [Asan Medical Center, University of Ulsan, Seoul (Korea, Republic of)

    1995-09-15

    Avascular necrosis(AVN) of bone can be resulted from various causes that disturb vascular supply to bone tissue, including steroid therapy after renal transplantation. In this study, we determine the prevalence of the avascular necrosis of bone after renal transplantation and compare the role of the bone scan, SPECT and MRI. In 301 patients with transplanted kidney, the prevalence of avascular necrosis was determined clinically. Site of bone necrosis was evaluated by clinical symptom, bone scan, SPECT and MRI. Bone scan was done in all patients with AVN. Bone SPECT and MRI were done in six cases; and MRI was done in two cases. The prevalence of AVN was 3.3% (10/301), and the site of AVN was 16 femoral heads in 10 patients (bilateral: 60%) and bilateral calcaneal tuberosity in one patient. Bone scan showed typical AVN (cold area with surrounding hot uptake) in 13 lesions, only hot uptake in three lesions (including two calcaneal tuberosities), decreased uptake in one lesion, and normal in one lesion. Decreased uptake and normal lesion showed an equivocal cold area without surrounding hot uptake on SPECT. A symptomatic patient with positive bone SPECT showed normal finding on MRI. The prevalence of AVN of bone after renal transplantation was 3.3%, and whole body bone scan showed multiple bone involvement. Two symptomatic hip joints without definite lesion on whole body bone scan or MRI showed cold defect on SPECT. Therefore, we conclude that bone SPECT should be performed in a symptomatic patient with negative bone scan or MRI in case with high risk of AVN after renal transplantation.

  16. Avascular Necrosis of Bone after Renal Transplantation - Prevalence and Usefulness of Bone SPECT -

    International Nuclear Information System (INIS)

    Choi, Yun Young; Yang, Seoung Oh; Ryuu, Jin Sook; Moon, Dae Hyuk; Lee, Hee Kyung

    1995-01-01

    Avascular necrosis(AVN) of bone can be resulted from various causes that disturb vascular supply to bone tissue, including steroid therapy after renal transplantation. In this study, we determine the prevalence of the avascular necrosis of bone after renal transplantation and compare the role of the bone scan, SPECT and MRI. In 301 patients with transplanted kidney, the prevalence of avascular necrosis was determined clinically. Site of bone necrosis was evaluated by clinical symptom, bone scan, SPECT and MRI. Bone scan was done in all patients with AVN. Bone SPECT and MRI were done in six cases; and MRI was done in two cases. The prevalence of AVN was 3.3% (10/301), and the site of AVN was 16 femoral heads in 10 patients (bilateral: 60%) and bilateral calcaneal tuberosity in one patient. Bone scan showed typical AVN (cold area with surrounding hot uptake) in 13 lesions, only hot uptake in three lesions (including two calcaneal tuberosities), decreased uptake in one lesion, and normal in one lesion. Decreased uptake and normal lesion showed an equivocal cold area without surrounding hot uptake on SPECT. A symptomatic patient with positive bone SPECT showed normal finding on MRI. The prevalence of AVN of bone after renal transplantation was 3.3%, and whole body bone scan showed multiple bone involvement. Two symptomatic hip joints without definite lesion on whole body bone scan or MRI showed cold defect on SPECT. Therefore, we conclude that bone SPECT should be performed in a symptomatic patient with negative bone scan or MRI in case with high risk of AVN after renal transplantation.

  17. [Mechanical behavior of the subchondral bone in the experimentally induced osteoarthritis].

    Science.gov (United States)

    Miyanaga, Y

    1979-06-01

    In order to evaluate the role of the subchondral bone (cancellous bone) in the development and progression of the joint degeneration, osteoarthritis of the knee joint was produced experimentally in the rabbits and viscoelasticity and strength of the subchondral bone from the femoral medial condyle have been investigated along with the pathological, histological study of the joint. The viscoelastic spectrometer and the Instron type testing machine were used. As the first change after operation, osteophyte formation around the joint margin has been observed before the initiation of the degeneration of articular cartilage and there is a possibility that mechanical properties of subchondral bone such as high deformability and low elasticity to the mechanism of osteophyte formation. Subchondral bone softening with marked increase of ultimate strain and phase lag, marked decrease of compressive elastic modulus and ultimate stress precedes or occurs concurrently with the degeneration of the articular cartilage. These facts indicate the relationship between the mechanical properties of the subchondral bone and joint degeneration. Once the joint degeneration starts, degeneration continues progressively while the subchondral bone tends to become brittle. These changes may be considered as a kind of functional adaptation to the damage or denudation of articular cartilage. It is postulated that some architectural changes of the subchondral bone may provide alterations of the mechanical properties. Biomechanical roles of the subchondral bone is suggested as one of the factors in the joint degeneration.

  18. Minimally invasive arthrodesis for chronic sacroiliac joint dysfunction using the SImmetry SI Joint Fusion system.

    Science.gov (United States)

    Miller, Larry E; Block, Jon E

    2014-01-01

    Chronic sacroiliac (SI) joint-related low back pain (LBP) is a common, yet under-diagnosed and undertreated condition due to difficulties in accurate diagnosis and highly variable treatment practices. In patients with debilitating SI-related LBP for at least 6 months duration who have failed conservative management, arthrodesis is a viable option. The SImmetry(®) SI Joint Fusion System is a novel therapy for SI joint fusion, not just fixation, which utilizes a minimally invasive surgical approach, instrumented fixation for immediate stability, and joint preparation with bone grafting for a secure construct in the long term. The purpose of this report is to describe the minimally invasive SI Joint Fusion System, including patient selection criteria, implant characteristics, surgical technique, postoperative recovery, and biomechanical testing results. Advantages and limitations of this system will be discussed.

  19. Methodological problems of sacroiliac joint scintigraphy

    International Nuclear Information System (INIS)

    Schoerner, W.; Haubold, U.

    1981-01-01

    Bone scintigraphy of the sacroiliac joints and the lumbar spine was performed in 35 patients with ankylosing spondylitis and 30 control subjects. The scans were evaluated by qualitative and quantitative assessment. The sacroiliac/sacrum ratio (index ISG/sacrum), the sacroiliac/lumbar spine ratio (index ISG/LWS), and the left sacroiliac joint/right sacroiliac joint ratio (index li. ISG/re. ISG) were calculated. The visual interpretation of colour scans proved to be unreliable. The index ISG/sacrum was more sensitive than the index ISG/LWS. The index li. ISG/re. ISG was helpful as an additional criterion. When digital sacroiliac joint scintigraphy is well standardized it can be considered as a useful technique in early diagnosis of ankylosing spondylitis. (orig.) [de

  20. Improvement of Performance Range of Centrifugal Compressors Gas by Surge Line Modification Using Active Controller Based on Fuzzy Logic

    Directory of Open Access Journals (Sweden)

    Pezhman Mohammadi

    2012-04-01

    Full Text Available In this work, surge of prevention is a critical problem in oil and gas industries, particularly when return gas flow or gas flow reduces in transportation of gas pipelines. This paper is illustrated new results about surge control of centrifugal compressors .surge phenomenon is flow unsteady state in compressors which causes damages seriously in compressor construction. Furthermore, it also demonstrates in comparison with anti surge control ،active surge control expands stability range.Active surge control which based on fuzzy logic،is the main idea that used in this investigation. Using fuzzy controller causes an improvement in compressor's condition and increase performance range of the compressor, in addition to prevention of any instability in compressor. The simulation results is also satisfactory.