WorldWideScience

Sample records for bolsters

  1. Zika Connection to Rare Nerve Disorder Bolstered by Study

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161325.html Zika Connection to Rare Nerve Disorder Bolstered by Study ... has developed the strongest evidence to date that Zika virus can cause a rare nerve disorder called ...

  2. Research and Teaching: Think before (and after) You Speak: Practice and Self-Reflection Bolster Oral Communication Skills

    Science.gov (United States)

    Sterling, Eleanor; Bravo, Adriana; Porzecanski, Ana Luz; Burks, Romi L.; Linder, Joshua; Langen, Tom; Fernandez, Denny; Ruby, Douglas; Bynum, Nora

    2016-01-01

    In this study, conservation biology faculty and practitioners from across the United States designed classroom exercises and teaching interventions intended to bolster oral communication skills. Through repeated oral presentation assignments integrated into course requirements, the authors examined individual student learning gains via…

  3. Utilizing intraspecific variation in phenotypic plasticity to bolster agricultural and forest productivity under climate change.

    Science.gov (United States)

    Aspinwall, Michael J; Loik, Michael E; Resco de Dios, Victor; Tjoelker, Mark G; Payton, Paxton R; Tissue, David T

    2015-09-01

    Climate change threatens the ability of agriculture and forestry to meet growing global demands for food, fibre and wood products. Information gathered from genotype-by-environment interactions (G × E), which demonstrate intraspecific variation in phenotypic plasticity (the ability of a genotype to alter its phenotype in response to environmental change), may prove important for bolstering agricultural and forest productivity under climate change. Nonetheless, very few studies have explicitly quantified genotype plasticity-productivity relationships in agriculture or forestry. Here, we conceptualize the importance of intraspecific variation in agricultural and forest species plasticity, and discuss the physiological and genetic factors contributing to intraspecific variation in phenotypic plasticity. Our discussion highlights the need for an integrated understanding of the mechanisms of G × E, more extensive assessments of genotypic responses to climate change under field conditions, and explicit testing of genotype plasticity-productivity relationships. Ultimately, further investigation of intraspecific variation in phenotypic plasticity in agriculture and forestry may prove important for identifying genotypes capable of increasing or sustaining productivity under more extreme climatic conditions.

  4. In the midst of a large measles outbreak, EDs take steps to bolster screening procedures, prevent potential transmissions.

    Science.gov (United States)

    2015-04-01

    A large, multi-state outbreak of measles is prompting EDs around the country to bolster their screening procedures and provide education to staff, most of whom have never seen a measles case. Dozens of people in more than 17 states have been confirmed to have the disease, with most of these cases associated with an outbreak that began at an amusement park in southern California. Measles is extremely contagious, infecting nine out of 10 people exposed to the virus if they are susceptible to the disease. In cases in which a contagious disease is suspected, experts advise emergency providers to protect themselves before proceeding to the traditional vital signs. It's a concept referred to as "vital sign zero." Once a measles case is confirmed, experts say emergency staff should isolate the patient with protection such as an N-95 mask, and inform both the hospital's infection control department and public health authorities.

  5. A Potential of Rail Vehicle Having Bolster with Side Bearers for Improving Curving Performance on Sharp Curves Employing Link-Type Forced Steering Mechanism

    Science.gov (United States)

    Tanifuji, Katsuya; Yaegashi, Naoki; Soma, Hitoshi

    The air spring of bolsterless bogie trucks, which have been widely employed in railway vehicles in recent years, undergoes a large distortion when the vehicles negotiate sharp curves in lines such as subway lines, and this can deteriorate the durability of air springs. Furthermore, bolsterless trucks tend to suffer from increased wheel lateral force around sharp curves with a radius of 100 m or less. In this paper we discuss the application of a link-type forced steering mechanism to bogie trucks with a bolster as a countermeasure against the above-mentioned situation. A numerical simulation is carried out using a MBS software, SIMPACK. As a result, under the condition of reduced longitudinal stiffness in the primary suspension, a bolster truck with the link-type steering mechanism exhibits the potential to suppress the wheel lateral force occurring around sharp curves. Also, the deterioration in running stability due to the application of the steering mechanism can be recovered by adding moderate lateral damping in the secondary suspension. In addition, the obtained wear index shows that the forced steering truck has decreased flange wear resulting from passing through sharp curves.

  6. China to Bolster Oil Stockpiles

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ China is accelerating the build-up of its oil reserves to avoid the economic dislocations the country suffered in 2008 from fluctuations in the world oil price.China will,in addition to the current four strategic petroleum reserve bases,build eight new ones by 2011.The program will increase China's strategic crude reserve capacity to 44.6 million cubic meters,or 281 million barrels.The country will also increase its oil products reserve to 10 million tons by 2011."China's attentiveness to its oil reserve capacity has grown in tandem with its rising dependence on imported oil," said Pan Jiahua,an expert with the Chinese petroleum society.

  7. New TRIUMF bolsters Canadian physics

    CERN Multimedia

    Gwynne, P

    2001-01-01

    Alan Shotter has been appointed director of TRIUMF. The ISAC accelerator there will be used to simulate astrophysical phenomena but the director will also be looking at ways to expand the research programme into other areas (1/2 page).

  8. Landsat helps bolster food security

    Science.gov (United States)

    ,

    2016-08-24

    One of the cruelest, most complex narratives in the world today (2016) is written in the hunger of sub-Saharan Africa. When famine is the only yield from the scorched Earth, survival often depends on a heart-rending calculation—how far is the distant feeding center; how close is the nearest well.

  9. Bolstering the U.S.Middle Class

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Making every attempt to boost the sluggish U.S.economy, U.S.President Barack Obama has pledged incentive programs including tax cuts for the middle class that have "for generations,made our economy the envy of the world." But the program may not be a panacea as income inequality in the United States becomes entrenched.Zhang Monan,a researcher with the State Information Center,discussed this issue in an article recently published in the China Securities Journal.Edited excerpts follow.

  10. 1929 Dünya Ekonomi Krizi Ve Ulusal Ekonomiyi Güçlendirme Mücadelesinde Kadınlar The Impact Of 1929 World Economic Crisis On Turkey And Women In Bolstering National Economy

    Directory of Open Access Journals (Sweden)

    Doğan DUMAN

    2013-07-01

    Full Text Available After the independence war, Turkey went through some radicalpolitical and legal amendments. Despite the worst picture in economy,Turkey obtained significant successes as a result of the exuberance ofthe new Republic. However, the crisis which broke out first in the USAand then spread to the other capitalistic countries and which wasconsidered as the first major global crisis shook and had its deepreverberations in Turkey. The first impact was the devaluation of theTurkish currency. Secondly, the prices in theagriculture field droppedand affected the economy radically.Like many nations in a similar situation, Turkey planned toundergo a new economic policy and initiated a self sustaining policy.Hence, new measures were taken to encourage the nation to consumethe local products and to start saving. As a result, to implement thepolicy to use the local produce and to save as possible, a lot ofcampaigns were launched. Turkish women had a special mission in thisstruggle. Women who started to take their place sociallyandeconomically in the modernization process in Republic, had anactive role to bolster the national economy. This study aims athighlighting the major causes of the crisis, the impact on Turkisheconomy and the place of women in this struggle to overcome the crisis. Bağımsızlık savaşının kazanılmasından sonra Türkiye’de öncelikle köklü siyasal ve hukuksal değişiklikler gerçekleştirildi. Ekonomi alanında devralınan olumsuz tabloya rağmen ise, yeni bir devlet kurmanın verdiği coşkuyla ekonomik alanda da küçümsenmeyecek başarılar elde edildi. Fakat 1920’lerin sonunda önce Amerika Birleşik Devletleri’nde daha sonra diğer büyük kapitalist ülkelerde ortaya çıkan ve kapitalist dünyanın ilk büyük ekonomi krizi olarak nitelendirilen 1929 Dünya Ekonomi Krizi Türkiye’yi de derinden sarstı. Krizin Türkiye’ye ilk yansıması Türk lirasının hızlı bir değer kaybına uğraması şeklinde oldu. Ard

  11. Using Professional Learning Communities to Bolster Comprehension Instruction

    Science.gov (United States)

    Dougherty Stahl, Katherine A.

    2015-01-01

    High-level comprehension instruction is the focus of the Common Core State Standards in English Language Arts. However, it has been a challenge for states to provide the professional development (PD) needed to support teachers' implementation of the CCSS. Professional learning communities (PLC) are a means of providing school-embedded PD to…

  12. Time will tell: resource continuity bolsters ecosystem services.

    Science.gov (United States)

    Schellhorn, Nancy A; Gagic, Vesna; Bommarco, Riccardo

    2015-09-01

    A common suggestion to support ecosystem services to agriculture provided by mobile organisms is to increase the amount of natural and seminatural habitat in the landscape. This might, however, be inefficient, and demands for agricultural products limit the feasibility of converting arable land into natural habitat. To develop more targeted means to promote ecosystem services, we need a solid understanding of the limitations to population growth for service-providing organisms. We propose a research agenda that identifies resource bottlenecks and interruptions over time to key beneficial organisms, emphasising their resulting population dynamics. Targeted measures that secure the continuity of resources throughout the life cycle of service-providing organisms are likely to effectively increase the stock, flow, and stability of ecosystem services.

  13. Survey Says: Using Teacher Feedback to Bolster Evaluation

    Science.gov (United States)

    Wiener, Ross; Lundy, Kasia

    2014-01-01

    Many of the leading private sector organizations have for years embraced a survey approach to improving products, services, and internal policies and processes. Like these successful private sector businesses, school systems can utilize a similar survey-based approach to improving teacher evaluation. Here, the authors provide and outline some…

  14. When Science Replaces Religion: Science as a Secular Authority Bolsters Moral Sensitivity.

    Science.gov (United States)

    Yilmaz, Onurcan; Bahçekapili, Hasan G

    2015-01-01

    Scientific and religious thinking compete with each other on several levels. For example, activating one generally weakens the other. Since priming religion is known to increase moral behaviour and moral sensitivity, priming science might be expected to have the opposite effect. However, it was recently demonstrated that, on the contrary, science priming increases moral sensitivity as well. The present set of studies sought to replicate this effect and test two explanations for it. Study 1 used a sentence unscrambling task for implicitly priming the concept of science but failed to replicate its effect on moral sensitivity, presumably due to a ceiling effect. Study 2 replicated the effect with a new measure of moral sensitivity. Study 3 tested whether science-related words create this effect by activating the idea of secular authority or by activating analytic thinking. It was demonstrated that words related to secular authority, but not words related to analytic thinking, produced a similar increase in moral sensitivity. Religiosity level of the participants did not influence this basic finding. The results are consistent with the hypothesis that science as a secular institution has overtaken some of the functions of religion in modern societies.

  15. 3D map of Universe bolsters case for dark energy and dark matter

    CERN Multimedia

    2003-01-01

    "Astronomers from the Sloan Digital Sky Survey (SDSS) have made the most precise measurement to date of the cosmic clustering of galaxies and dark matter, refining our understanding of the structure and evolution of the Universe" (1 page).

  16. Planning during turmoil: credit challenges and healthcare finance. Interview by Carole J. Bolster.

    Science.gov (United States)

    Bigalke, John T; Goldstein, Lisa; Gourdon, Claudia; Jacobson, Catherine A; Kaufman, Kenneth; Long, Ronald R

    2008-11-01

    The crisis in the financial markets is having a major impact on hospitals' ability to access capital. Providers are seeking longer-term fixed-rate debt rather than shortterm debt. Hospital management teams and their boards need to understand the upside and downside of variable-rate debt and interest rate derivatives.

  17. Make the Case for Coaching: Bolster Support with Evidence That Coaching Makes a Difference

    Science.gov (United States)

    Eisenberg, Ellen; Medrich, Elliott

    2013-01-01

    Policymakers want to see evidence that coaching makes a difference for teachers and students. To this group, making a difference means improving performance on standardized tests. In the current fiscal climate, leaders want to know not only that their investments are based on firm grounds theoretically, but also that instructional coaching works.…

  18. Bolstering the Evidence Base for Integrating Abortion and HIV Care: A Literature Review

    Directory of Open Access Journals (Sweden)

    Ruth Manski

    2012-01-01

    Full Text Available HIV-positive women have abortions at similar rates to their HIV-negative counterparts, yet little is known about clinical outcomes of abortion for HIV-positive women or the best practices for abortion provision. To fill that gap, we conducted a literature review of clinical outcomes of surgical and medication abortion among HIV-positive women. We identified three studies on clinical outcomes of surgical abortion among HIV-positive women; none showed significant differences in infectious complications by HIV status. A review of seven articles on similar gynecological procedures found no differences in complications by HIV status. No studies evaluated medication abortion among HIV-positive women. However, we did find that previously expressed concerns regarding blood loss and vomiting related to medication abortion for HIV-positive women are unwarranted based on our review of data showing that significant blood loss and vomiting are rare and short lived among women. We conclude that although there is limited research that addresses clinical outcomes of abortion for HIV-positive women, existing data suggest that medication and surgical abortion are safe and appropriate. Sexual and reproductive health and HIV integration efforts must include both options to prevent maternal mortality and morbidity and to ensure that HIV-positive women and women at risk of HIV can make informed reproductive decisions.

  19. POWERDRESS and diversified expression of the MIR172 gene family bolster the floral stem cell network.

    Directory of Open Access Journals (Sweden)

    Rae Eden Yumul

    Full Text Available Termination of the stem cells in the floral meristem (also known as floral determinacy is critical for the reproductive success of plants, and the molecular activities regulating floral determinacy are precisely orchestrated during the course of floral development. In Arabidopsis thaliana, regulators of floral determinacy include several transcription factor genes, such as APETALA2 (AP2, AGAMOUS (AG, SUPERMAN (SUP, and CRABSCLAW (CRC, as well as a microRNA (miRNA, miR172, which targets AP2. How the transcription factor and miRNA genes are coordinately regulated to achieve floral determinacy is unknown. A mutation in POWERDRESS (PWR, a previously uncharacterized gene encoding a SANT-domain-containing protein, was isolated in this study as an enhancer of the weakly indeterminate ag-10 allele. PWR was found to promote the transcription of CRC, MIR172a, b, and c and/or enhance Pol II occupancy at their promoters, without affecting MIR172d or e. A mutation in mature miR172d was additionally found to enhance the determinacy defects of ag-10 in an AP2-dependent manner, providing direct evidence that miR172d is functional in repressing AP2 and thereby contributes to floral determinacy. Thus, while PWR promotes floral determinacy by enhancing the expression of three of the five MIR172 members as well as CRC, MIR172d, whose expression is PWR-independent, also functions in floral stem cell termination. Taken together, these findings demonstrate how transcriptional diversification and functional redundancy of a miRNA family along with PWR-mediated co-regulation of miRNA and transcription factor genes contribute to the robustness of the floral determinacy network.

  20. Teaching Managers To Relate: Using Feedback To Bolster Commitment And Morale

    Directory of Open Access Journals (Sweden)

    Donald C. Smith

    2011-07-01

    Full Text Available Every text, indeed all writing in communication, either does or should stress the centrality of feedback in basic and advanced models of communication.  Most work in this area has focused on taking feedback, distilling information and using it to make good decisions.  What is lost in the traditional understanding is that feedback can be used to establish good relations.  A manager’s feedback can enhance employee/manger relationships, strengthen loyalty and commitment, and increase morale. This paper examines how managers can use feedback to make important and genuine connections with their employees; thereby getting the greatest return on human resources. A theory based “do and don’t do” framework is offered.  Establishing any good relationship is simply a matter of knowing what to say, how to say it, when and to whom.  It’s 9:00 a.m.; do you know who your employees are?

  1. Better Patient Care At High-Quality Hospitals May Save Medicare Money And Bolster Episode-Based Payment Models.

    Science.gov (United States)

    Tsai, Thomas C; Greaves, Felix; Zheng, Jie; Orav, E John; Zinner, Michael J; Jha, Ashish K

    2016-09-01

    US policy makers are making efforts to simultaneously improve the quality of and reduce spending on health care through alternative payment models such as bundled payment. Bundled payment models are predicated on the theory that aligning financial incentives for all providers across an episode of care will lower health care spending while improving quality. Whether this is true remains unknown. Using national Medicare fee-for-service claims for the period 2011-12 and data on hospital quality, we evaluated how thirty- and ninety-day episode-based spending were related to two validated measures of surgical quality-patient satisfaction and surgical mortality. We found that patients who had major surgery at high-quality hospitals cost Medicare less than those who had surgery at low-quality institutions, for both thirty- and ninety-day periods. The difference in Medicare spending between low- and high-quality hospitals was driven primarily by postacute care, which accounted for 59.5 percent of the difference in thirty-day episode spending, and readmissions, which accounted for 19.9 percent. These findings suggest that efforts to achieve value through bundled payment should focus on improving care at low-quality hospitals and reducing unnecessary use of postacute care.

  2. Cancer screening and health system resilience: keys to protecting and bolstering preventive services during a financial crisis.

    Science.gov (United States)

    Martin-Moreno, Jose M; Anttila, Ahti; von Karsa, Lawrence; Alfonso-Sanchez, Jose L; Gorgojo, Lydia

    2012-09-01

    The aim of this paper is to elucidate the rationale for sustaining and expanding cost-effective, population-based screening services for breast, cervical and colorectal cancers in the context of the current financial crisis. Our objective is not only to promote optimal delivery of high-quality secondary cancer prevention services, but also to underline the importance of strengthening comprehensive cancer control, and with it, health system response to the complex care challenges posed by all chronic diseases. We focus primarily on issues surrounding planning, organisation, implementation and resources, arguing that given the growing cancer burden, policymakers have ample justification for establishing and expanding population-based programmes that are well-organised, well-resourced and well-executed. In a broader economic context of rescue packages, deficits and cutbacks to government entitlements, health professionals must intensify their advocacy for the protection of vital preventive health services by fighting for quality services with clear benefits for population health outcomes.

  3. WWW.com: A Brief Intervention to Bolster a 5th Grader's Regrouping Skills in Math

    Science.gov (United States)

    Waugh, Matthew; Harrison, Gina L.

    2014-01-01

    This study examined the efficacy of a brief math intervention using cognitive behaviour instruction (CBI) supplemented by a mnemonic cue system for a 5th grade student with math computation and fluency difficulties. Regrouping operations in addition and subtraction were the targeted skills. Curriculum-based measurements were conducted at the end…

  4. Effect of a large gaming neighborhood and a strategy adaptation neighborhood for bolstering network reciprocity in a prisoner's dilemma game

    Science.gov (United States)

    Ogasawara, Takashi; Tanimoto, Jun; Fukuda, Eriko; Hagishima, Aya; Ikegaya, Naoki

    2014-12-01

    In 2 × 2 prisoner's dilemma (PD) games, network reciprocity is one mechanism for adding social viscosity, leading to a cooperative equilibrium. In this paper, we explain how gaming neighborhoods and strategy-adaptation neighborhoods affect network reciprocity independently in spatial PD games. We explore an appropriate range of strategy adaptation neighborhoods as opposed to the conventional method of making the gaming and strategy adaptation neighborhoods coincide to enhance the level of cooperation. In cases of expanding gaming neighborhoods, network reciprocity falls to a low level relative to the conventional setting. In the discussion below, which is based on the results of our simulation, we explore how these enhancements come about. Essentially, varying the range of the neighborhoods influences how cooperative clusters form and expand in the evolutionary process.

  5. A finite element lower extremity and pelvis model for predicting bone injuries due to knee bolster loading

    NARCIS (Netherlands)

    Rooij, L. van; Hoof, J. van; Barbir, A.; Made, R. van der; Slaats, P.M.A.; McCann, M.J.; Ridella, S.A.; Rupp, J.D.

    2004-01-01

    Injuries to the knee-thigh-hip (KTH) complex in frontal motor vehicle crashes are of substantial concern because of their frequency and potential to result in long-term disability. Current frontal impact Anthropometric Test Dummies (ATDs) have been shown to respond differently than human cadavers un

  6. Global representation of threatened amphibians ex situ is bolstered by non-traditional institutions, but gaps remain

    DEFF Research Database (Denmark)

    Biega, A; Greenberg, D.A.; Mooers, A.O.

    2017-01-01

    priority by testing how eight variables relating to extinction risk – International Union for the Conservation of Nature status, habitat specialization, obligate stream breeding, geographic range size, body size and island, high-altitude and tropical endemism – vary between amphibian species held in zoos...... greater overall extinction risk in the near future. We strongly encourage zoos to continue increasing their holdings of amphibian species, but to pay greater attention to these species of particular conservation concern....

  7. Nanotech Bolsters Semiconductor Manufacturing Gradually%纳米技术逐渐成为半导体制造业的支柱

    Institute of Scientific and Technical Information of China (English)

    Alexander E.Braun

    2006-01-01

    从表面看,纳米技术正在不断发展,但发展成效距离其发展目标-取代CMOS技术还相差甚远.由于纳米技术的主要发展方向定位于支持而不是超越当前技术,因此CMOS正在演变为纳米技术的发展平台.

  8. Increasing the Chances of Implementing NGSS by Bolstering High School Teacher Knowledge and Views about Climate Change, a NICE NASA Example

    Science.gov (United States)

    Bleicher, R. E.

    2013-12-01

    Purpose of Presentation This paper will highlight how the results of this initial study foreshadow possibilities of NGSS (NGSS, 2013) playing out in high school classrooms in the near future. Research findings from a three-year NASA-funded project, Promoting Educational Leadership in Climate Science (PEL) will be presented. Objectives and Research Questions PEL aims to increase climate science literacy in high school teachers and students through scientific argumentation using authentic NASA data. This initial study focuses on the following questions: 1. Are teachers increasing their climate science knowledge? 2. Are there changes in teachers' views about climate change? 3. What resources and are provided to assist teachers to develop their students' scientific argumentation skills? Theoretical Framework Because of the changing nature of climate science knowledge and its relevance to societal issues, teachers must be able to understand the basic concepts and remain up-to-date on scientific issues. The need for a more thorough understanding of the concepts of climate change are highlighted by recent studies on the public perceptions and attitudes on the subject (Leiserowitz et al., 2013). Teachers need to understand the difference between skepticism as a characteristic of the nature of science and denial of climate change (Sommervillle & Hasol, 2011). Teachers need to understand the natural and human-induced factors affecting climate, and the potential consequences, and ways to mitigate and adapt to climate change. Generally, when teachers learn about a subject, they demonstrate more self-efficacy to teach about it (Bleicher & Lindgren, 2005). Analytic Strategy Data were analyzed using paired-samples t-tests, independent t -tests, and ANOVA. Latent class analysis was employed to analyze the Six America's Survey data. Correlational studies were conducted to examine possible relationships among variables. Findings in Brief Teachers' content knowledge increased significantly and teachers were more concerned about climate change after participation in PEL. Teachers with higher self-efficacy demonstrated higher climate change science knowledge. Teachers indicated that they felt more confident and were motivated to implement classroom lessons with their students that employed resources rich in NASA climate data and focused on scientific argumentation. References Bleicher, R.E., & Lindgren, J. (2005). Success in learning science and preservice science teaching self-efficacy. Journal of Science Teacher Education. 16, 205-225. Leiserowitz, A., Maibach, E., Roser-Renouf, C., Feinberg, G., & Howe, P.(2013) Climate change in the American mind: Americans' global warming beliefs and attitudes in April, 2013 Yale University and George Mason University. New Haven, CT: Yale Project on Climate Change Communication. Retrieved 7/26/13 from: http://climatechangecommunication.org/sites/default/files/reports/Climate-Beliefs-April-2013.pdf Next Generation Science Standards (NGSS). (2013). Available at http://www.nextgenscience.org/print/121. Somerville, R. C. J. & Hassol, S. J. (2011). Communicating the science of climate change. Physics Today, 64(10), 48-53.

  9. China's New Deal

    Institute of Scientific and Technical Information of China (English)

    LEO ZHANG

    2008-01-01

    @@ The RMB4-trillion stimulus package is a bold move, but the economy still needs attention China unveiled a massive spending package in November to bolster investment and consumption as exports falter amid the global economic slowdown.

  10. A Balanced Approach to Funding Homeland Security

    Science.gov (United States)

    2014-12-01

    Operational Coordination Forensics and Attribution Access Control and Identity Verification Community Resilience Critical Transportation...equipment used during the event, such as bomb robots, x-ray equipment, and ballistic helmets and vests.127 • Operational communications were bolstered

  11. China Institute Proposes Weaker Yuan to Boost Growth

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ China should actively guide the yuan's exchange rate to about 6.93 against the dollar to help maintain economic growth and bolster employment, according to a report by the Ministry of Finance's research institute.

  12. A Time for Flexible Donor Agreements.

    Science.gov (United States)

    Fischer, Gerald B.

    2003-01-01

    Discusses why volatile markets and new donor expectations make now a good time to rework payout rates and gift agreements to bolster financial and strategic performance. Suggests seven options for action. (EV)

  13. 75 FR 48691 - Single Source Cooperative Agreement Award for the World Health Organization (WHO) To Continue...

    Science.gov (United States)

    2010-08-11

    ... light of the threat of an influenza pandemic it was originally designed with the goals of bolstering..., programmatic support, and familiarity with international vaccine production institutions have been and will...

  14. University commercialization policies and their implementation in the Netherlands and the United States

    NARCIS (Netherlands)

    Leisyte, Liudvika

    2011-01-01

    The article explores how the US and Dutch governments have attempted to bolster research commercialization in their respective research systems and discusses the institutionalization of linkages between universities and industrial firms. First, the article shows how the institutional framework condi

  15. Working with numbers and statistics a handbook for journalists

    CERN Document Server

    Livingston, Charles

    2005-01-01

    Working With Numbers and Statistics: A Handbook for Journalists will bolster math skills and improve math confidence for journalists at all skill levels. Authors Charles Livingston and Paul Voakes developed this resource book to improve journalist

  16. Oil Refining Giants to Cut Output

    Institute of Scientific and Technical Information of China (English)

    Zhang Dingmin

    2002-01-01

    @@ China's refined oil product output rose slightly in the first five months of this year on strong demand,but the two biggest domestic producers plan to cut production rates in an attempt to bolster the sluggish price.

  17. 76 FR 31680 - Open Meeting of the President's Council on Jobs and Competitiveness (PCJC)

    Science.gov (United States)

    2011-06-01

    ... initiatives and policies to strengthen the economy, promote and accelerate job growth and bolster America's... the government and business can work together to foster growth and create jobs. The PCJC will...

  18. Disinformation overload.

    Science.gov (United States)

    Wagner, L

    1994-08-01

    Lawmakers and special-interest groups are working with the government as well as private consulting groups to bolster their reform positions with statistics. Experts, however, fear the barrage of healthcare reform research will only add to the public's confusion.

  19. The great escape: the role of self-esteem and self-related cognition in terror management

    OpenAIRE

    2015-01-01

    Integrating terror management theory and objective self-awareness theory, we propose the\\ud existential escape hypothesis, which states that people with low self-esteem should be\\ud especially prone to escaping self-awareness as a distal response to thoughts of death. This is\\ud because they lack the means to bolster the self as a defense, and the propensity to bolster the\\ud self reduces the motivation to escape from self-awareness. Five studies supported this\\ud hypothesis. Individuals low,...

  20. Optimal active redundancy allocation in k-out-of-n system

    OpenAIRE

    Mi, Jie

    1999-01-01

    A k-out-of-n system consisting of n components is one that works if and only if at least k of the n components work. Suppose there are n+r (1 ≤ r ≤ n) components available of which r will be used for active redundancy. From the given n+r components, r components are chosen to be used as active redundancies, and another r components receive active redundancies (i.e. these r components are bolstered). Consider a k-out-of-n system consisting of the r bolstered and the oth...

  1. Globalization Crises, Trade,and Development in Vietnam

    DEFF Research Database (Denmark)

    Abbott, Philip; Tarp, Finn

    that dependence and bolster the domestic economy while continuing to restructure the economy toward greater emphasis on the private sector. Growth, employment and poverty alleviation have been maintained at the expense of renewed inflation, larger budget deficits, and currency depreciation. The ‘stop-go’ nature...

  2. Is Prescott right? Welfare state policies and the incentives to work, learn, and retire

    NARCIS (Netherlands)

    B. Jacobs (Bas)

    2009-01-01

    textabstractThis paper bolsters Prescott's (Fed. Reserve Bank Minneap. Q. Rev. 28(1):2-13, 2004) claim that high taxes are responsible for lackluster labor market performance in Continental European countries. We develop a life-cycle model with endogenous skill formation, endogenous labor supply, an

  3. Assessing Conscientious Personality in Primary Care: An Opportunity for Prevention and Health Promotion

    Science.gov (United States)

    Israel, Salomon; Moffitt, Terrie E.

    2014-01-01

    The articles in this special section bolster the already strong evidence base that personality differences in the trait of conscientiousness predict health. What is now needed is a research agenda for translating documented risk associations between low conscientiousness and poor health into policies and interventions that improve health outcomes…

  4. Examining the Role of Social Network Intervention as an Integral Component of Community-Based, Family-Focused Practice

    Science.gov (United States)

    Cox, Kathleen F.

    2005-01-01

    Social network intervention aimed at bolstering the informal supports of high risk families is recognized as a common element of community-based, family-focused practice models, such as intensive family preservation services (IFPS), multisystemic therapy (MST), and the wraparound process. The empirical research basis for these practice models is…

  5. Evaluation of the Urban Crime Prevention Program. Executive Summary.

    Science.gov (United States)

    Roehl, Janice A.; Cook, Royer F.

    The Urban Crime Prevention Program (UCPP) was designed to combat urban crime through the establishment of 85 innovative neighborhood-based crime prevention projects across nine cities for 18 months. UCPP's main goals were to increase citizen participation in innovative neighborhood crime prevention efforts, to bolster the capabilities of…

  6. Practice Stories in Natural Resource Management Continuing Professional Education: Springboards for Learning

    Science.gov (United States)

    Stummann, Cathy Brown

    2014-01-01

    The use of stories from professional experience in continuing professional education has been on the rise in many fields, often aimed at bolstering capacity through sharing professional knowledge and/or supporting reflective practice. Practice stories are also suggested to be beneficial in supporting professional learning of new concepts. These…

  7. A Delve into the Deployment of eCommerce and Higher Educational Learning

    Science.gov (United States)

    Djoleto, Wilhelmina

    2012-01-01

    Higher Educational Institutions (HEIs) and organisations have made significant investments in eCommerce/eBusiness in efforts to keep up with heightened technology penetration in organisational and institutional fabrics. These efforts have been incorporated in their strategic mission partly, to bolster their reputation. HEIs reputation depends much…

  8. Biodemography of human ageing

    DEFF Research Database (Denmark)

    Vaupel, James W

    2010-01-01

    Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implications for individuals, society and the economy. Remarkably, the rate of deterioration with age seems...

  9. An Inevitable Moment: US Brain Drain

    Science.gov (United States)

    Coppola, Brian P.

    2015-01-01

    In this article, Brian Coppola begins by discussing the 2007 National Academies of Sciences (NAS) publication, "Rising Above the Gathering Storm" which called for for reprioritizing investments because "the world is changing rapidly, and our advantages are no longer unique. Without a renewed effort to bolster the foundations of our…

  10. Leading to High Performance: A Case Study of the Role of the Balanced Scorecard in Improving Urban Secondary Schools

    Science.gov (United States)

    Brown, Pamela C.

    2010-01-01

    The onset of the standards-based movement in education in the early 1980's, bolstered by the passing of the No Child Left Behind Act (NCLBA) of 2002, led many school districts to shift from a culture of regulatory, process-oriented compliance to one that is more results-oriented, primarily based on state-adopted summative assessment targets in…

  11. Apples and Oranges Mean a New Fruit Crop: New Business Plan Competition Model Integrates Economic and Community Development

    Science.gov (United States)

    Feldman, Jacqueline; Oden, Lisa Derby

    2007-01-01

    Mount Wachusett Community College Entrepreneurial Resource Center Business Plan Competition brings together stakeholders across all economic sectors to bolster the regional economy. It also highlights entrepreneurs as a viable career choice. The competition disintegrates existing silos, provides education to all entrants, and gives business…

  12. Strategic Shock: The Collapse of the Soviet Union: 1989

    Science.gov (United States)

    2010-08-01

    dissatisfaction with aggressive foreign policy.13 The resulting changes in domestic attitude bolstered support for retrenchment within key policy circles. So...by 30 percent, and industrial production stood at less than 50 percent of the 1989 level. Unemployment …exceed(ed) 30 percent of the labour force.”37

  13. Increasing Interest in Social Studies: Social Perspective Taking and Self-Efficacy in Stimulating Simulations

    Science.gov (United States)

    Gehlbach, Hunter; Brown, Scott W.; Ioannou, Andri; Boyer, Mark A.; Hudson, Natalie; Niv-Solomon, Anat; Maneggia, Donalyn; Janik, Laura

    2008-01-01

    This study examined the potential of simulations to bolster interest in middle school social studies classrooms. Using a pre-post-design, we examined 305 middle school students (49% female) who participated in the web-based "GlobalEd" simulation. In contrast to the motivation declines middle school students usually experience, participants in this…

  14. Vitality and Ethnolinguistic Attitudes of Acadians, Franco-Ontarians and Francophone Quebecers: Two or Three Solitudes in Canada's Bilingual Belt?

    Science.gov (United States)

    Sioufi, Rana; Bourhis, Richard Y.; Allard, Réal

    2016-01-01

    Do French-Canadian (FC) minorities in New Brunswick and Ontario remain as committed as majority Francophone Quebecers in developing their vitality within Canada's bilingual belt? FCs constitute host communities for interprovincial migrants of FC and English-Canadian (EC) background who can bolster or weaken the vitality of FCs. How FCs and ECs…

  15. Justifying Educational Language Rights

    Science.gov (United States)

    May, Stephen

    2014-01-01

    The author of this chapter observes that post-9/11 there has been a rapid and significant retrenchment of multiculturalism as public policy, particularly within education. This apparent retrenchment of multiculturalism as public policy has been bolstered by parallel arguments for a more "cosmopolitan" approach to education within an…

  16. Aiming High: Exploring the Influence of Implementation Fidelity and Cognitive Demand Levels on Struggling Readers' Literacy Outcomes

    Science.gov (United States)

    Feldman, Jill; Feighan, Kelly; Kirtcheva, Elena; Heereen, Elizabeth

    2012-01-01

    Researchers studied components of a two-year school-wide Striving Readers intervention aimed at bolstering middle school teachers' use of literacy strategies to raise students' reading achievement. Although students of intervention teachers had significantly higher Iowa Test of Basic Skills (ITBS) scores than students of non-participating…

  17. How Military Service Affects Student Veteran Success at Community Colleges

    Science.gov (United States)

    O'Rourke, Patrick C., Jr.

    2013-01-01

    Increasingly more service members are separating from the military as the United States draws down the force and moves towards a post-war era. Tens of thousands of these veterans will leverage their GI Bill tuition and housing benefits in an attempt to access Southern California community colleges and bolster their transition into mainstream…

  18. Smartphone and mobile phone security for the clinician.

    Science.gov (United States)

    Barber, Harry

    2016-08-02

    Smartphones are near ubiquitous and widely used by doctors in discussing patients. In all communication doctors should take steps to protect confidentiality, yet there is a paucity of available information on how clinicians can bolster cyber security and minimize risk when using their mobile phone.

  19. Deconstructing and Developing the Attitudes of Primary School Readers

    Science.gov (United States)

    Ortileb, Evan

    2015-01-01

    Improving student attitudes toward reading remains of particular concern to elementary school teachers. The development of students' demeanour toward reading is as important, if not more so, than skill enhancement. Unless reading attitudes are maintained and even bolstered, content instruction will not always reach the learner, nor will students…

  20. Using the World Wide Web To Teach Francophone Culture.

    Science.gov (United States)

    Beyer, Deborah Berg; Van Ells, Paula Hartwig

    2002-01-01

    Examined use of the World Wide Web to teach Francophone culture. Suggests that bolstering reading comprehension in the foreign language and increased proficiency in navigating the Web are potential secondary benefits gained from the cultural Web-based activities proposed in the study.(Author/VWL)

  1. 77 FR 58299 - National Hispanic-Serving Institutions Week, 2012

    Science.gov (United States)

    2012-09-19

    ... By the President of the United States of America A Proclamation Equipping our children with the..., technology, education, and other fields that will bolster our economic prosperity and foster American... childhood education to combating high school dropout rates--and to supporting those institutions that...

  2. School System (Re)design: Developing Educational Infrastructures to Support School Leadership and Teaching Practice

    Science.gov (United States)

    Hopkins, Megan; Woulfin, Sarah L.

    2015-01-01

    A central challenge for local education agencies (i.e., school districts in the United States) undergoing reform is to design systems that facilitate instructional improvement. At the core of these systems are educational infrastructures that bolster capacity building efforts and support teaching and leadership practices. Our goal for this special…

  3. A World of Competitors: Assessing the US High-Tech Advantage and the Process of Globalisation

    Science.gov (United States)

    Douglass, John Aubrey

    2008-01-01

    Research universities throughout the world are part of a larger effort by countries to bolster science and technological innovation and compete economically. The United States remains highly competitive as a source of high-tech innovation because of a number of market positions, many the results of long-term investments in institutions (such as…

  4. Universities, the US High Tech Advantage, and the Process of Globalization. Research & Occasional Paper Series: CSHE.8.2008

    Science.gov (United States)

    Douglass, John Aubrey

    2008-01-01

    Research universities throughout the world are part of a larger effort by nation-states to bolster science and technological innovation and compete economically. The US remains highly competitive as a source of High Tech (HT) innovation because of a number of market positions, many the result of long term investments in institutions such as…

  5. China’s Energy Insecurity and the South China Sea Dispute

    Science.gov (United States)

    2011-03-24

    action also served to bolster China’s claims over US protectionism , containment, and potential ambitions to control the energy sector by diverting...and coal reserves; however, this has proven insufficient. With globalization, the days of state-proclaimed “neo- isolationism ” or “self-sufficiency

  6. Gaming the System: Culture, Process, and Perspectives Supporting a Game and App Design Curriculum

    Science.gov (United States)

    Herro, Danielle

    2015-01-01

    Games and digital media experiences permeate the lives of youth. Researchers have argued the participatory attributes and cognitive benefits of gaming and media production for more than a decade, relying on socio-cultural theory to bolster their claims. Only recently have large-scale efforts ensued towards moving game play and design into formal…

  7. Biomedical Research and the Animal Rights Movement: A Contrast in Values.

    Science.gov (United States)

    Morrison, Adrian R.

    1993-01-01

    This article explains how animals are used in research in an effort to counteract animal rights literature. Reveals how medical professionals and others trained in scholarship have misquoted the scientific literature to bolster their claims against the utility of animal research. (PR)

  8. Enjoying the Roller Coaster Ride: Directors' Perspectives on Fostering Staff Morale in University Counseling Centers

    Science.gov (United States)

    Eells, Gregory T.; Seals, Tom; Rockett, Jeri; Hayes, Denise

    2005-01-01

    The demand for mental health services in higher education settings continues to increase and places more pressure on staff, highlighting further the importance of good staff morale in these agencies. This task of bolstering staff morale is often placed primarily on the shoulders of counseling center directors. The present article outlines several…

  9. Moving On

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Ningxia bolsters its economic strength by tapping into Arab markets and green industries For centuries,northwest China’s Ningxia Hui Autonomous Region was a prominent fulcrum on the Silk Road,an ancient trade route linking China and the Western world via the Middle East.

  10. Euro-Philiacs, Euro-Sceptics and Europhobics: Higher Education Policy, Values and Institutional Research

    NARCIS (Netherlands)

    Neave, Guy

    2005-01-01

    The European higher education landscape is inhabited by three clans: the Euro-philiac, his wicked twin, the Euro-phobic and most interesting of all, the Euro-sceptic. This unholy trinity has long been with us. Though the recent Euro electoral fiasco has in all probability served to bolster the ranks

  11. The Role of Transnational Feminism in Psychology: Complementary Visions

    Science.gov (United States)

    Grabe, Shelly; Else-Quest, Nicole M.

    2012-01-01

    Denmark and Segovich's (2012), Hyde's (2012), and Marecek's (2012) reflections on the authors' article (Else-Quest & Grabe, 2012) further bolster the need for feminist psychology to investigate gender disparities in power. The authors offer a rejoinder that draws together the commonalities in their various perspectives by putting the study of…

  12. How Wide Is a Squid Eye? Integrating Mathematics into Public Library Programs for the Elementary Grades

    Science.gov (United States)

    Kliman, Marlene; Jaumot-Pascual, Nuria; Martin, Valerie

    2013-01-01

    Although public library programs for the elementary grades offer explorations in a wide range of topics in which mathematics plays a role, are all too rare: Mathematics offerings are typically limited to homework help. Participating in out-of-school activities that embed mathematics in authentic ways bolsters children's skill development,…

  13. Entanglements of Consumption, Cruelty, Privacy, and Fashion: The Social Controversy over Fur.

    Science.gov (United States)

    Olson, Kathryn M.; Goodnight, G. Thomas

    1994-01-01

    Posits a critical approach to the study of contemporary social controversy. Examines objectives to the use of fur as oppositional argument, rhetoric that veers from the goal of persuasion to block conventional associations and refashion communication norms. Shows how pro-fur responses illustrate strategies available to bolster, alter, or abandon…

  14. 75 FR 58277 - National Employer Support of the Guard and Reserve Week, 2010

    Science.gov (United States)

    2010-09-23

    ... Forces. Making up nearly half of our military force, the men and women in the National Guard and Reserve... demands of civilian and military life. During this week, we pay special tribute to the employers of our Guardsmen and Reservists, whose support and flexibility bolster the contributions of these brave men...

  15. CGRP and its receptors provide new insights into migraine pathophysiology

    DEFF Research Database (Denmark)

    Ho, Tony W; Edvinsson, Lars; Goadsby, Peter J

    2010-01-01

    Over the past 300 years, the migraine field has been dominated by two main theories-the vascular theory and the central neuronal theory. The success of vasoconstrictors such as ergotamine and the triptans in treating acute migraine bolstered the vascular theory, but evidence is now emerging...

  16. Locking in on Latin America

    Institute of Scientific and Technical Information of China (English)

    MICHAEL; RICE

    2006-01-01

    China cautious as it sets up generous investment in Latin America The United States is keeping a watchful eye as China bolsters political and economic ties with Latin America. The situation has U.S. political analysts trying to determine just how China s emerging influence

  17. 77 FR 55097 - National Preparedness Month, 2012

    Science.gov (United States)

    2012-09-06

    ..., emergencies and natural disasters have tested the fabric of our country. During National Preparedness Month... recover from natural disasters that have spanned historic drought to devastating wildfires and storms, we... role to play in bolstering our preparedness for disasters of all types--from cyber incidents and...

  18. 3 CFR 8415 - Proclamation 8415 of September 14, 2009. National Employer Support of the Guard and Reserve Week...

    Science.gov (United States)

    2010-01-01

    ... the ultimate sacrifice for our country. They help respond to natural disasters and humanitarian... Armed Forces and helps protect our country. Our Guard and Reserve personnel are training arduously and... support and flexibility, employers across the country bolster the efforts of members of the Guard...

  19. Resistance towards persuasion: differences between non-profit and commercial advertising

    NARCIS (Netherlands)

    Boogaard, C.R.; Fransen, M.L.; Eisend, M.; Langner, T.

    2011-01-01

    In the present research we examined a variety of strategies that consumers may use to resist persuasion towards non-profit and commercial advertising. Based on research by Jacks and Cameron (2003), we investigated seven strategies (i.e., attitude bolstering, counter arguing, negative affect, selecti

  20. The Family, Flexible Work and Social Cohesion at Risk.

    Science.gov (United States)

    Carnoy, Martin

    1999-01-01

    Because of women's increased participation in the labor market, there is an increasing pressure on families. Women are expected to provide stability, focus on child development, and bolster colleagues against unemployment and retraining, whereas society is expected to provide child care facilities and flexible education. (JOW)

  1. Organizational Social Effectiveness: An Annotated Bibliography

    Science.gov (United States)

    2014-01-01

    self-deception indicate a tendency for leaders to bolster their self-image as a leader in a way that is consistent with romanticized leadership. The...Overall, the results suggest that leaders tend to distort their self-images of leadership style to reflect romanticized ideals of leadership and that

  2. One Team, One Fight: The Need for Security Assistance Reform

    Science.gov (United States)

    2012-01-01

    architecture throughout the Cold War utilized security assistance funding to bolster the defenses of regional allies against the spread of fascism and...ceiling on sales that must be approved by Congress, currently at $14 million for major defense articles for nations besides Japan , Australia, New Zealand

  3. Leadership Handbook for the Armor Officer. Volume 2. Headaches, Heartbeats, and Hamstrings: A Guide to Company Level Duties and Functions

    Science.gov (United States)

    1986-01-01

    rctcs 8h reaiztiotathe s ollwi. cors ththsbeucssu o tesi imlrcr mtne !-- ",/,,"-,. bolsters.’.-’ his.. confdene ad.ecouage.h. to.. adhere... Vulcan - Antiaircraft Weapon System w -With wa- Weather I WESS - Weapons Effect Signature Simulator WESTCC14 - US Army Western Command WETS - Weekend

  4. The Aims, Methods, and Effects of Deliberative Civic Education through the National Issues Forums.

    Science.gov (United States)

    Gastil, John; Dillard, James P.

    1999-01-01

    Examines the goals, methods, and effects of four current deliberative civic education programs, with an in-depth analysis of one: the National Issues Forums (NIF). Shows that NIF can bolster participants' political self-efficacy, refine their political judgments, broaden their political conversation networks, and reduce their conversational…

  5. Rethinking US Security Policy for the 1980s. Proceedings of the Annual National Security Affairs Conference (7th) held 21-23 July 1980, Fort McNair, Washington, DC.

    Science.gov (United States)

    1980-01-01

    they revealed American, French, Moroccan , and implicit Saudi (and perhaps Iranian) involvement in the effort to bolster the Mobutu regime in Zaire...de desarmement," Politique Etrangere 44 (1979): 213-248. 8. For recent commentary on European monetary policy, see Benjamin J. Cohen, "Le SME . le

  6. Plant macro- and micronutrient dynamics in a biochar-amended wetland muck

    Science.gov (United States)

    Drainage of Histosols (mucks) in the Florida Everglades Agricultural Area (EAA) has resulted in extensive subsidence. Decreases in profile thickness threatens long-term agricultural sustainability of the EAA. We hypothesized that biochars could bolster sustainability of these mucks by rebuilding th...

  7. Ideology, Materiality, and Counterpublicity: William E. Simon and the Rise of a Conservative Counterintelligentsia

    Science.gov (United States)

    Asen, Robert

    2009-01-01

    As a conceptual term, "counterpublic" serves scholarship best when contributing to a critical-theory project, which means that particular constellations of materiality and ideology may bolster some calls for counterpublicity while gainsaying others. This may be investigated by examining how a text upholds or betrays an advocate's values, seeking…

  8. Rising above the Gathering Storm, Revisited: Rapidly Approaching Category 5

    Science.gov (United States)

    National Academies Press, 2010

    2010-01-01

    In the face of so many daunting near-term challenges, U.S. government and industry are letting the crucial strategic issues of U.S. competitiveness slip below the surface. Five years ago, the National Academies prepared "Rising Above the Gathering Storm," a book that cautioned: "Without a renewed effort to bolster the foundations of…

  9. Patching genes to fight disease

    Energy Technology Data Exchange (ETDEWEB)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  10. SOE Execs:Get Ready For Stock Incentives

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Stock option incentive plan will soon be available to state-owned enterprise executives, but will it lead to greater prosperity or new problems? Atrailblazing new scheme to infuse state-owned enterprises (SOEs) with incentive stock options is underway. It's a plan that may bolster company performance, but it's

  11. Partnership for the Advancement of Information Literacy in a Nursing Program

    Science.gov (United States)

    Beck, Sheila; Blake-Campbell, Barbara; McKay, Devin

    2012-01-01

    Nursing educators know that healthcare stakeholders expect nursing graduates to be able to manage information. Consequently, many nursing education programs are exploring ways of integrating information literacy across the curriculum not only to bolster evidence-based practice, but also to enhance professional development and encourage lifelong…

  12. Rhetoric and Gender in Jane Austen's "Persuasion."

    Science.gov (United States)

    Walzer, Arthur E.

    1995-01-01

    Argues for a reading of Jane Austen's "Persuasion" that undermines Joseph Duffy's reading of the novel as a commentary on shifting social class structures, and which bolsters Nancy Armstrong's reading as a commentary on female voice and the values of the domestic household. Interprets the novel in the light of 18th-century rhetorical…

  13. Does Early Adolescent Sex Cause Depressive Symptoms?

    Science.gov (United States)

    Sabia, Joseph J.

    2006-01-01

    A recent study by the Heritage Foundation (Rector, Johnson, & Noyes, 2003) found evidence of a positive relationship between early sexual intercourse and depressive symptoms. This finding has been used to bolster support for funding abstinence only sex education. However, promoting abstinence will only yield mental health benefits if there is…

  14. 78 FR 66613 - National Diabetes Month, 2013

    Science.gov (United States)

    2013-11-05

    ... treatment. Diabetes can lead to serious complications, including heart disease, stroke, kidney failure, and... Americans to talk to their health care provider about steps they can take to prevent or manage this disease..., advancing work toward improved treatment and care, and bolstering prevention efforts. Thanks to...

  15. The Impact of Motivational Interviewing on Client Experiences of Cognitive Behavioral Therapy for Generalized Anxiety Disorder

    Science.gov (United States)

    Kertes, Angela; Westra, Henny A.; Angus, Lynne; Marcus, Madalyn

    2011-01-01

    Motivational Interviewing (MI) has recently been applied to the treatment of anxiety disorders in an effort to bolster engagement with and response rates to cognitive behavioral therapy (CBT). In a recent randomized control trial, the addition of MI as a pretreatment compared to no pretreatment was found to significantly improve response to CBT…

  16. Sanctuary … and Other Notes from the "NEJHE" Beat …

    Science.gov (United States)

    Harney, John O.

    2016-01-01

    How will higher education fare under a President Donald Trump? According to this author, the campaign's misogyny shouldn't sit well with a student body that is now majority female, its disavowal of climate changes won't impress research universities, and the xenophobia won't help economies and cultures bolstered by foreign enrollment. The number…

  17. Time to Wrap Up Doha

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Completion of the negotiations will bolster confidence in world economic growth The Doha Round of global trade talks, which kicked off in 2001,has lasted for quite some time.Despite huge differences among parties involved in the talks,it is now highly essential to complete

  18. "Process and Intention": A Thirtieth-Year Reflection

    Science.gov (United States)

    Gebhardt, Richard

    2011-01-01

    "Process and Intention: A Bridge from Theory to Classroom" is rooted in a time when intuitive, experience-based awareness that we should "Teach Writing as a Process Not Product" (Murray 3) was bolstered by systematic research into the complexity of writing. Lots of years have passed since those days, so as a reminder, the author mentions five…

  19. Lessons Learned from the Collaborative Writing Process

    Science.gov (United States)

    Bhavsar, Victoria; Ahn, Ruth

    2013-01-01

    We reflect on how to implement the instrumental aspect of collaborative writing in such a way that the developmental aspect of collaborative writing is maximally fostered, based on conditions necessary for socially constructed learning. We discuss four instrumental strategies that bolster mutual ownership of the writing and protect the social…

  20. Getting Students Excited about Learning: Incorporating Digital Tools to Support the Writing Process

    Science.gov (United States)

    Saulsburry, Rachel; Kilpatrick, Jennifer Renée; Wolbers, Kimberly A.; Dostal, Hannah

    2015-01-01

    Technology--in the form of digital tools incorporated into writing instruction--can help teachers motivate and engage young children, and it may be especially critical for students who do everything they can to avoid writing. Technology may bolster student involvement, foster the engagement of reluctant or struggling writers, and support writing…

  1. Mood-Congruent Memory and Natural Mood: New Evidence.

    Science.gov (United States)

    Mayer, John D.; And Others

    1995-01-01

    Presents new evidence that everyday mood does bring about a hypothesized effect on memory, termed mood-congruent memory (MCM). Results of three studies provided evidence for MCM among normal individuals (n=614). Findings support prior studies and bolster notions that mood and memory constantly covary in everyday experience. (RJM)

  2. Case Study: Fuel Cells Provide Combined Heat and Power at Verizon's Garden City Central Office

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-12-01

    This case study describes how Verizon's Central Office in Garden City, NY, installed a 1.4-MW phosphoric acid fuel cell system as an alternative solution to bolster electric reliability, optimize the company's energy use, and reduce costs in an environmentally responsible manner.

  3. Parents' Interactions with Preschoolers during Shared Book Reading: Three Strategies for Promoting Quality Interactions

    Science.gov (United States)

    Han, Jisu; Neuharth-Pritchett, Stacey

    2014-01-01

    Research shows that home environments play a critical role in developing children's early literacy skills. Given the importance of developing early literacy skills to bolster children's chances for subsequent academic success, this article highlights the role of parent-child shared book reading. Summarizing research on different types of…

  4. Cosmic Ray Accelerators in the Large Magellanic Cloud

    CERN Document Server

    Butt, Yousaf M

    2010-01-01

    I point out a correlation between gamma-ray emissivity and the historical star formation rate in the Large Magellanic Cloud ~12.5 Myr ago. This correlation bolsters the view that CRs in the LMC are accelerated by conglomerations of supernova remnants: i.e. superbubbles and supergiant shells.

  5. The Overriding Interest

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Twenty years ago,far-sighted leaders of China and the Association of Southeast Asian Nations(ASEAN)launched a dialogue that deep-ened mutual understanding and trust,and helped forge close cooperation between the two sides.Since then,China and ASEAN have bolstered part-nerships in

  6. A Blended Model: Simultaneously Teaching a Quantitative Course Traditionally, Online, and Remotely

    Science.gov (United States)

    Lightner, Constance A.; Lightner-Laws, Carin A.

    2016-01-01

    As universities seek to bolster enrollment through distance education, faculty are tasked with maintaining comparable teaching/learning standards in traditional, blended, and online courses. Research has shown that there is an achievement gap between students taking courses exclusively offered online versus those enrolled in face-to-face classes.…

  7. Flipping the COIN and Winning: Lessons from Colombia

    Science.gov (United States)

    2009-03-01

    covert support for the murderous paramilitaries. In 2002, surfing a wave of popular discontent with escalating violence and lawlessness, the Colombian...action” program improves child nutrition , bolsters health, and empowers women. In 2002, the program served 150,000 children. They aided nearly 800,000 in

  8. The Spread of Contingent Work in the Knowledge-Based Economy

    Science.gov (United States)

    Szabo, Katalin; Negyesi, Aron

    2005-01-01

    Permanent employment, typical of industrial societies and bolstered by numerous social guaranties, has been declining in the past 2 decades. There has been a steady expansion of various forms of contingent work. The decomposition of traditional work is a logical consequence of the characteristic patterns of the knowledge-based economy. According…

  9. 78 FR 26701 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity and...

    Science.gov (United States)

    2013-05-08

    ... strengthen liquidity risk management at Farm Credit System (System) banks, improve the quality of assets in their liquidity reserves, and bolster the ability of System banks to fund their obligations and continue...-AC54 Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity...

  10. 78 FR 37101 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity and...

    Science.gov (United States)

    2013-06-20

    ... liquidity risk management at Farm Credit System (System) banks, improve the quality of assets in their liquidity reserves, and bolster the ability of System banks to fund their obligation and continue operations... at Farm Credit System (System) banks, improve the quality of assets in their liquidity reserves,...

  11. 76 FR 80817 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity and...

    Science.gov (United States)

    2011-12-27

    ...) banks, improve the quality of assets in the liquidity reserve, and bolster the ability of System banks... banks to pay their obligations and fund their operations by maintaining adequate liquidity to withstand... at all FCS banks; Enhance the marketability of assets that System banks hold in their...

  12. 78 FR 23437 - Funding and Fiscal Affairs, Loan Policies and Operations, and Funding Operations; Liquidity and...

    Science.gov (United States)

    2013-04-18

    ... Credit, or System) banks, improve the quality of assets in their liquidity reserves, and bolster the... banks to pay their obligations and fund their operations by maintaining adequate liquidity to withstand... at all FCS banks; Enhance the liquidity of assets that System banks hold in their liquidity...

  13. Pushing the Entrepreneurial Prodigy: Canadian Aboriginal Entrepreneurship Education Initiatives

    Science.gov (United States)

    Pinto, Laura Elizabeth; Blue, Levon Ellen

    2016-01-01

    Globally, neoliberal education policy touts youth entrepreneurship education as a solution for staggering youth unemployment, a means to bolster economically depressed regions, and solution to the ill-defined changing marketplace. Many jurisdictions have emphasized a need for K-12 entrepreneurial education for the general population, and targeted…

  14. Where's the Vision? The Concept of Utopia in Contemporary Educational Theory

    Science.gov (United States)

    Webb, Darren

    2009-01-01

    This paper explores the way in which the concept of utopia is employed within contemporary educational theory. Confronted with the relentless marketisation and managerialisation of education, there is a growing willingness to embrace utopianism as a means of bolstering hope, opening up new possibilities and catalysing change. At the same time,…

  15. Academic Outcomes of Developmental Community College Online and Face-to-Face Classes: The Differences between Male and Female Students

    Science.gov (United States)

    White, Gailynn

    2013-01-01

    Earning a college degree has become a near necessity for men and women to compete in the U.S. workforce today. Despite this necessity, many students graduate from high school without the necessary skills to succeed in college. A large number of those students look to the U.S. community college system to bolster their skills in reading, English,…

  16. LEADERSHIP EFFECTIVENESS IN CROSS-CULTURAL BUSINESS ENVIRONMENT

    OpenAIRE

    GOSTROUSHKO VLADLENA

    2015-01-01

    Businesses are operating in an increasingly global environment, which requires careful consideration of cultural differences when marketing goods and services worldwide. Whether you are dealing with international partners or setting up an office in an overseas location, understanding typical leadership styles in that country can be extremely beneficial to bolstering smooth-running relationships.

  17. The Elementary & Secondary Education Act: New Leaders Recommendations on School Leadership

    Science.gov (United States)

    New Leaders, 2015

    2015-01-01

    This brief outlines a series of proposals for using federal policy to bolster school leadership. The Elementary & Secondary Education Act (ESEA) should highlight the unique role that principals play by targeting funding within the law to build principals' capacity as instructional leaders, culture builders and talent managers. ESEA should also…

  18. Conceptualizing Media Stimuli in Experimental Research: Psychological versus Attribute-Based Definitions

    Science.gov (United States)

    Tao, Chen-Chao; Bucy, Erik P.

    2007-01-01

    This paper argues for a clearer conceptualization of media stimuli in experimental research and identifies 3 issues impeding our understanding of message processing: (a) assumptions bolstered by manipulation checks about homogeneity of response to media stimuli, (b) conflation of 2 different classes of variables--media attributes and psychological…

  19. From Shards to Stained Glass: Crowdsourcing an E-Book

    Science.gov (United States)

    Fontichiaro, Kristin

    2012-01-01

    In this article, the author discusses crowdsourcing an e-book--gathering wide, diverse opinions from the school library community (including academics, practitioners, vendors, and others), and gathering those results in a free e-book. As e-book publishers, school librarians could be active agents, bolstering community energy, creating a forum for…

  20. Crucial Levy Goes down in Cleveland: Loss Could Mean Layoffs, Blow to Superintendent

    Science.gov (United States)

    Gewertz, Catherine

    2005-01-01

    Cleveland voters soundly rejected a levy intended to bolster the school district's finances, a move widely interpreted as a referendum on the performance of its leader, Barbara Byrd-Bennett. Two-thirds of the voters who turned out for the Aug. 2 special election cast their ballots against Issue 3, which would have raised more than $45 million to…

  1. Ecocultural Patterns of Family Engagement among Low-Income Latino Families of Preschool Children

    Science.gov (United States)

    McWayne, Christine M.; Melzi, Gigliana; Limlingan, Maria Cristina; Schick, Adina

    2016-01-01

    For the 5 million low-income Latino children in the United States who are disproportionately impacted by the numerous risk factors associated with poverty, it is essential to identify proximal protective factors that mitigate these risks and bolster the academic and social skills that are foundational to a successful transition into formal…

  2. Cruising to the Expo

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Shanghai’s 2010 World Expo is a golden opportunity to bolster China’s cruise ship industry shanghai’s cruise ship port broke a number of records in 2009.The port saw 182,000 passenger visits via international cruise liners throughout the year,an increase of 73 percent over the year before.

  3. Demanding More: Legal Standards and Best Practices for English Language Learners

    Science.gov (United States)

    Haas, Eric; Gort, Mileidis

    2009-01-01

    In the current english-only programs in California, Arizona, and Massachusetts only a small percentage of students are learning English and subject matter content. This violates the success in practice prong of "Castaneda v. Pickard" (1981). Further, these program failures bolster the claim that these programs also violate castaneda's…

  4. A socioecological approach to improving mammography rates in a tribal community.

    Science.gov (United States)

    English, Kevin C; Fairbanks, Jo; Finster, Carolyn E; Rafelito, Alvin; Luna, Jolene; Kennedy, Marianna

    2008-06-01

    This article highlights the processes and intermediate outcomes of a pilot project to increase mammography rates of women in an American Indian tribe in New Mexico. Using a socioecological framework and principles of community-based participatory research, a community coalition was able to (a) bolster local infrastructure to increase access to mammography services; (b) build public health knowledge and skills among tribal health providers; (c) identify community-specific knowledge, attitudes, and beliefs related to breast cancer; (d) establish interdependent partnerships among community health programs and between the tribe and outside organizations; and (e) adopt local policy initiatives to bolster tribal cancer control. These findings demonstrate the value of targeting a combination of individual, community, and environmental factors, which affect community breast cancer screening rates and incorporating cultural strengths and resources into all facets of a tribal health promotion intervention.

  5. The dynamics of the three-piece-freight truck

    DEFF Research Database (Denmark)

    Xia, Fujie

    2002-01-01

    and dynamical contact relations between wheels and rails, the nonlinear suspensions and the nonlinear dry friction damping. For low speeds of the truck the kinematic and dynamical nonlinearities might be linearized, but the very strongly nonlinear suspensions and the dry friction damping can not be linearized...... body and the side supports on the bolsters the side supports must be modelled as nonlinear dead-band springs. The clearances in the assembly in the wedge damper systems give rise to a relative yaw motion of the bolster with respect to the side frame and a rotation around the truck center line and cause...... a warping. In addition the assembly clearances between the side frame and the adapter both in longitudinal and lateral directions produce another dead-band spring force. The tractive effort on the car body in the longitudinal direction may be left out of consideration in the modelling of the passenger car...

  6. Can My Image Appear on APOD?: How APOD Really Works

    Science.gov (United States)

    Nemiroff, Robert J.; Bonnell, Jerry T.

    2017-01-01

    The Astronomy Picture of the Day (APOD) makes an effort to present and annotate the best astronomical images of our time. How "best" is defined in practice is debatable and will be discussed. However, if your image appears destined to appear in future astronomy textbooks, there is a good chance it will be highlighted on APOD. Perhaps the most ambitious goal of APOD is to bolster astronomy as a globally unifying medium, highlighting that all of humanity shares the night sky. Perhaps the least ambitious goal is to find enough time to prepare a reasonably interesting and error-free APOD for tomorrow. In practice, APOD has been cited by many teachers of astronomy as making educational images easily available to bolster their lectures and give a background understandable to their students. Feedback from teachers is therefore particularly encouraged.

  7. Source Credibility and Persuasion: The Role of Message Position in Self-Validation.

    Science.gov (United States)

    Clark, Jason K; Evans, Abigail T

    2014-05-12

    Highly credible communicators have been found to elicit greater confidence and attitudes that are based more on recipients' thoughts (i.e., self-validation) compared with non-credible sources. However, source credibility may produce different effects on thought confidence and persuasion depending on the position of an advocacy. When messages are proattitudinal, credible sources should initiate self-validation because recipients may be motivated to confirm (bolster) their existing views. Conversely, when appeals are counterattitudinal, recipients may be motivated to defend their opinions and disconfirm information. In these contexts, greater self-validation may emerge when a communicator lacks rather than possesses credibility. When a message was counterattitudinal and contained weak arguments, evidence of self-validation was found with low source credibility (Studies 1 and 2) and among participants high in defense motivation (Study 2). In response to strong, proattitudinal arguments, findings were consistent with high credibility producing self-validation when bolstering motivation was high (Study 3).

  8. Restriction of Variance Interaction Effects and Their Importance for International Business Research

    DEFF Research Database (Denmark)

    Cortina, Jose M.; Köhler, Tine; Nielsen, Bo Bernhard

    2015-01-01

    hypothesis that is very common in international business (IB) research: the restricted variance (RV) hypothesis. Specifically, we describe the nature of an RV interaction and its evidentiary requirements. We also offer several IB examples involving interactions that could have been supported with RV...... arguments. Our hope is that IB researchers can use this paper to bolster their arguments for interaction hypotheses by explaining them in terms of RV....

  9. An Examination of US Policy Toward Iranian Nuclear Proliferation

    Science.gov (United States)

    2007-03-30

    William K. Miller United States Army Colonel Keith Ferrell Project Adviser This SRP is submitted in partial fulfillment of...Middle States Association of Colleges and Schools, 3624 Market Street, Philadelphia, PA 19104, (215) 662-5606. The Commission on Higher Education is an...directly or covertly. The second concerns Iran’s nuclear policy which seeks to bolster its national pride thereby supporting regime stability as well

  10. Prevent: A Fragmented Counter-Terrorism Strategy

    Science.gov (United States)

    2015-05-21

    combat training and military operations overseas. Bolstered with Saudi funding, young British Muslims had the opportunity to travel within three...Mirror Online, “Muslim Worshippers: It’s Madness; Exclusive Army To Scots Cadets: Don’t Wear Uniform near Mosque in Case You Offend ,” Muslims, accessed...and offender management services - and the local community.61 The statutory partners assess individual vulnerability by employing three discreet

  11. Agent-Based Cloud Computing

    OpenAIRE

    Sim, Kwang Mong

    2012-01-01

    Agent-based cloud computing is concerned with the design and development of software agents for bolstering cloud service\\ud discovery, service negotiation, and service composition. The significance of this work is introducing an agent-based paradigm for\\ud constructing software tools and testbeds for cloud resource management. The novel contributions of this work include: 1) developing\\ud Cloudle: an agent-based search engine for cloud service discovery, 2) showing that agent-based negotiatio...

  12. Human Rights and Military Conduct: A Progress Report

    Science.gov (United States)

    2000-01-01

    dilemma involves threats such as drug trafficking, organized crime, and terrorism . In most mature democracies responsibility for dealing with such threats...promoting reform to bolster civilian control and respect for human rights. That dilemma was underscored when Peruvian President Alberto Fujimori re...better guarantees could be assured. Asked whether he feared sanctions and a possible cutoff of aid from the United States, Fujimori replied, “What

  13. Vliv značky na kupní chování spotřebitele

    OpenAIRE

    Aliapulios, Telis

    2017-01-01

    The diploma thesis concerns with influence of Apple brand on consumer buying behavior. The aim of thesis is to qualify the influence of brand on consumer buying behavior on smartphone market. From this conditions will arise the recommendations to Apple company, how is possible to bolster its position on mobile phone market. The theoretical part of thesis place emphasis on description of marketing mix, brand theory and consumer buying behavior. Practical part is based on studied secondary data...

  14. The effects of a combined enforcement and public information campaign on seat belt use.

    OpenAIRE

    1986-01-01

    It is generally agreed that seat belt use is effective in preventing (fatal) driver injuries, and that legislation is an effective measure for increasing their use. Nevertheless, legislation alone rarely proves sufficient to achieve anything near universal usage. Policy makers can reach for a number of measures to bolster seat belt use. This paper presents some of the results of an evaluation of a combined enforcement and public information campaign that was conducted in 1984 in Friesland.

  15. Globalization and health--some issues.

    Science.gov (United States)

    Rowson, M

    2000-01-01

    Globalization is happening. But it appears that it has been associated with a rise in inequalities both between and within nations. Financial and trade liberalization, the main motors of the current phase of globalization, have been introduced with reckless abandon and little thought to the consequences. Future policy advice must bolster the role of the state in defending populations from the excesses of market forces, and there should be rigorous analysis of the health and other social impacts of economic policies.

  16. Tang Liying, GM of Aili Corporation, Talks with WOC

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    AILI Tower is famous in Haikou, Hainan Province, because it was built when the real estate market was at its most depressed. The completion of the Western-style building not only added another edifice to the landscape of this once-isolated island, but served to bolster people’s confidence and strengthen their resolve to build China’s second largest island into a

  17. Strategy: The Logic of War and Peace rev. and enlarged ed. by Edward N. Luttwak Cambridge, MA: The Belknap Press of Harvard University Press, 2001 / Book Review

    OpenAIRE

    Wirtz, James J.

    2003-01-01

    In the 1980s scholars in the ªelds of history and political science rediscovered the work of Carl von Clausewitz, the Prussian philosopher of war. This renewed interest sparked a brief revival of the study of war and strategy (the latter of which encompasses efforts to exploit war’s dialectic to achieve military and political victory). After relying for decades on operations research to minimize the likelihood of nuclear war by bolstering deterrence—an approach that largely eli...

  18. Blast Technologies

    Science.gov (United States)

    2011-06-27

    rollover  VAT: Vertical forces and floor deformation  HIP : Head protection systems Payoff: MABS  State-of-the-art unique piece of test equipment...13 14 15 16 17 Energy Absorbing Seats w/ Restraints Blast Mats and other Interior Treatments Data Recorders and Sensors Methods and Standards... treatments .  Airbag or comparable technologies such as bolsters.  Sensors that can detect and deploy/trigger interior treatments within the timeframe of a

  19. The role of popular territories in participatory budgeting of the cities of Porto Alegre and Rosario

    Directory of Open Access Journals (Sweden)

    Gisela Vanina SIGNORELLI

    2016-05-01

    Full Text Available The cities of Porto Alegre and Rosario have been pioneers in implementing citizen participation policies, Participatory Budgeting (pb being the most symbolic. The aim of this paper is to examine how pb has influenced on the reaffirmation of new centralities and on the bolstering of peripheries of those two cities (1989-2012, analyzing its contribution in terms of social cohesion, through the inclusion of popular sectors.

  20. Current practices and guidelines for clinical next-generation sequencing oncology testing

    Institute of Scientific and Technical Information of China (English)

    Samuel P. Strom

    2016-01-01

    Next-generation sequencing (NGS) has been rapidly integrated into molecular pathology, dramatically increasing the breadth genomic of information available to oncologists and their patients. This review will explore the ways in which this new technology is currently applied to bolster care for patients with solid tumors and hematological malignancies, focusing on practices and guidelines for assessing the technical validity and clinical utility of DNA variants identified during clinical NGS oncology testing.

  1. Female Participation in Formed Police Units: A Report on the Integration of Women in Formed Police Units of Peacekeeping Operations

    Science.gov (United States)

    2012-09-01

    per year have jumped significantly in number and complexity. Numbering in the high teens , these PKOs go well beyond cease-fire monitoring to include...possessing the highest literacy rate in Af- rica, Congo under Belgian colonial rule had never sys- tematically educated its citizens past the age of four- teen ...of women in FPUs could have bolstered the ONUSAL mission. Further, although El Salvador experienced a lower level of sexual or gender-based

  2. The American economist Martin Bronfenbrenner (1914-1997) and the reconstruction of the Japanese economy (1947-1952): (a version for presentation in East Asia)

    OpenAIRE

    Ikeo, Aiko

    2011-01-01

    Martin Bronfenbrenner (1914-1997) was an American economist who was conversant with Japanese counterparts and well informed in Japan's economics and economy. This paper aims to examine how he managed to communicate with Japanese economists when he visited Japan (three times) during the period immediately after the conclusion of the Pacific War (1941-1945). It also discusses his caustic criticism of the monetary expansion policy started by Japanese Finance Minister Tanzan Ishibashi to bolster ...

  3. Scientists taste entrepreneurial life

    Directory of Open Access Journals (Sweden)

    Paula Gould

    2005-11-01

    Full Text Available Financing retirement from university life with the proceeds of a smart invention is undeniably an attractive prospect. Unfortunately, attempts to commercialize academic research can result all too easily in knock-backs and disappointed investors, rather than a generous pension deposit. But, if you pitch the right idea to the right market, money can be made. Not only that, the technology could do a great deal of good, while also bolstering its inventor's curriculum vitae.

  4. Should knowledge of classical dance be essential for medical practitioners?

    Directory of Open Access Journals (Sweden)

    Shovana T Narayan

    2014-07-01

    Full Text Available The medical field is constantly throwing challenges, leading to considerable stress for its practitioners. Medical practitioners are expected to be professional, have up-to-date knowledge and expertise, and the ability to withstand fatigue. Through it all they are expected to remain motivated, respectful and humane, patient and kind, and confident and sensitive. The author demonstrates how learning dance can stimulate creativity, increase motivation and bolster social intelligence in medical practitioners.

  5. Desert Talons: Historical Perspectives and Implications of Air Policing in the Middle East

    Science.gov (United States)

    2009-04-01

    ground. The United States Air Force’s bombing of the Ho Chi Minh Trail in order to control wide swaths of territory and counter the infiltration of...complemented the capabilities of the aircraft with patrols in urban areas (an acknowledged weak spot of air control) gathering local intelligence and providing...occasion, of an impending flood due to a burst dam.48 Show of force sorties enhanced the legitimacy and bolstered the power of the government without

  6. Study protocol: effects of school gardens on children’s physical activity

    OpenAIRE

    Nancy M. Wells; Myers, Beth M; Henderson, Charles R.

    2014-01-01

    Background Childhood obesity is an epidemic. Strategies are needed to promote children’s healthy habits related to diet and physical activity. School gardens have the potential to bolster children’s physical activity and reduce time spent in sedentary activity; however little research has examined the effect of gardens on children’s physical activity. This randomized controlled trial (RCT) examines the effect of school gardens on children’s overall physical activity and sedentary behavior; an...

  7. PAPEL DA EMBRAPA NO DESENVOLVIMENTO DO AGRONEGÓCIO

    OpenAIRE

    Marra, Renner; Geraldo da Silva e Souza; Alves, Eliseu Roberto de Andrade

    2013-01-01

    To describe Embrapa role in the development of the agribusiness it was important to characterize the economic environment that prevailed in the sixties and beginning of the seventies to show that the creation and development of Embrapa was a conscious decision of the federal government to bolster agricultural production and exports to solve food supply deficiencies and balance of pay-ment problems. The mandate of Embrapa was very specific and clear: to generate technology for the adoption of ...

  8. Defending the jurisdiction of the clinical ethicist.

    Science.gov (United States)

    Evans, John H

    2014-01-01

    In this essay I suggest that the bioethics profession's jurisdiction over healthcare ethics consultation is in need of reinforcement. I argue that as the profession becomes more successful, competitors will challenge the profession to justify its ethical claims and ask whose ethics the profession represents. This challenge will come more quickly as the profession tries to influence the ethics of healthcare organizations. I propose a method of bolstering jurisdiction that will make the profession less vulnerable to challenge in the future.

  9. Pathway analysis of whole exome sequence data provides further support for the involvement of histone modification in the aetiology of schizophrenia.

    Science.gov (United States)

    Curtis, David

    2016-10-01

    Weighted burden pathway analysis was applied to whole exome sequence data for 2045 schizophrenic patients and 2045 controls. Overall, there was a statistically significant excess of pathways with more rare, functional variants in cases than in controls. Among the highest ranked were pathways relating to histone modification, as well as neuron differentiation and membrane and vesicle function. This bolsters the evidence from previous studies that histone modification pathways may be important in the aetiology of schizophrenia.

  10. CAES Annual Report FY 2011

    Energy Technology Data Exchange (ETDEWEB)

    Kortny Rolston

    2011-10-01

    The Center for Advanced Energy Studies was created to lead research programs important to the nation, attract students and faculty to the Idaho universities and act as a catalyst for technology-based economic development. CAES is striving to meet those goals by continuing to develop its infrastructure and equipment capabilities, expand its research portfolio and bolster Idaho's energy workforce. This Annual Report details the progress CAES made in FY 2011 toward fulfilling its research, education and economic development missions.

  11. China Struggles to Meet Energy Shortage

    Institute of Scientific and Technical Information of China (English)

    李端奇

    2005-01-01

    China is making plans not only to bolster1 energy production to meet everincreasing domestic needs2 but also to cut down on overall energy use in coming years. Headed by Premier Wen Jiabao, China's cabinet3 unveiled its longer-term energy development plan, in which the heart of the program is to be as energy-efficient and environmentally friendly as possible while pursuing4 economic growth between now and 2020.

  12. Liberia’s Post-War Development: Key Issues and U.S. Assistance

    Science.gov (United States)

    2010-05-25

    non-violence, and safeguarding and promotion of constitutional and civil liberties and rights. She stressed the need for national reconciliation as an...that The situation in and around Liberia’s rubber plantations continued to be of concern. Labour disputes, including over salary and severance...bolster the program planning and management capabilities of the Ministry of Health. Education programs center on teacher training, with a special program

  13. Evaluating the European Defense Force

    Science.gov (United States)

    2002-05-31

    and Haitian Armed Forces ( FADH ) had initiated joint patrolling operations. This caused no small amount of angst among a populace who expected removal...sincerity of US intentions and contributed to demobilizing the FRAPH elements. In one instance a firefight broke out among Marine forces and FADH elements...that helped convince the local populace and 50 later, the rest of the country, that it was not in the US plan to retain and bolster FADH forces.26

  14. The Influence of Concentrative Meditation Training on the Development of Attention Networks during Early Adolescence

    Directory of Open Access Journals (Sweden)

    Shruti eBaijal

    2011-07-01

    Full Text Available We investigate if concentrative meditation training (CMT offered during adolescent development benefits subsystems of attention using a quasi-experimental design. Attentional alerting, orienting, and conflict monitoring were examined using the Attention Network Test (ANT in 13, 14, and 15 yo children who received CMT as part of their school curriculum (CMT Group: N=79 vs. those who received no such training (Control Group: N=76. Alerting and conflict monitoring, but not orienting, differed between the CMT and Control Group. Only conflict monitoring demonstrated age-related improvements, with smaller conflict effect scores in older vs. younger participants. The influence of CMT on this system was similar to the influence of developmental maturity, with smaller conflict effects in the CMT vs. Control group. To examine if CMT might also bolster conflict-triggered upregulation of attentional control, conflict effects were evaluated as a function of previous trial conflict demands (high conflict vs. low conflict. Smaller current trial conflict effects were observed when previous conflict was high vs. low, suggesting that similar to adults, when previous conflict was high (vs. low children in this age-range proactively upregulated control so that subsequent trial performance was benefitted. The magnitude of conflict-triggered control upregulation was not bolstered by CMT but CMT did have an effect for current incongruent trials preceded by congruent trials. Thus, CMT’s influence on attention may be tractable and specific; it may bolster attentional alerting, conflict monitoring and reactive control, but does not appear to improve orienting.

  15. Simplified geometric model for the calculation of neutron yield in an accelerator of 18 MV for radiotherapy; Modelo geometrico simplificado para el calculo del rendimiento de neutrones en un acelerador de 18 MV para radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Paredes G, L.C.; Balcazar G, M. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico); Francois L, J.L. [FI-UNAM, 04510 Mexico D.F. (Mexico); Azorin N, J. [UAM-I, 09340 Mexico D.F. (Mexico)

    2008-07-01

    The results of the neutrons yield in different components of the bolster of an accelerator Varian Clinac 2100C of 18 MV for radiotherapy are presented, which contribute to the radiation of flight of neutrons in the patient and bolster planes. For the calculation of the neutrons yield, a simplified geometric model of spherical cell for the armor-plating of the bolster with Pb and W was used. Its were considered different materials for the Bremsstrahlung production and of neutrons produced through the photonuclear reactions and of electro disintegration, in function of the initial energy of the electron. The theoretical result of the total yield of neutrons is of 1.17x10{sup -3} n/e, considering to the choke in position of closed, in the patient plane with a distance source-surface of 100 cm; of which 15.73% corresponds to the target, 58.72% to the primary collimator, 4.53% to the levelled filter of Fe, 4.87% to the levelled filter of Ta and 16.15% to the closed choke. For an initial energy of the electrons of 18 MeV, a half energy of the neutrons of 2 MeV was obtained. The calculated values for radiation of experimental neutrons flight are inferior to the maxima limit specified in the NCRP-102 and IEC-60601-201.Ed.2.0 reports. The absorbed dose of neutrons determined through the measurements with TLD dosemeters in the isocenter to 100 cm of the target when the choke is closed one, is approximately 3 times greater that the calculated for armor-plating of W and 1.9 times greater than an armor-plating of Pb. (Author)

  16. Applying a Family-Level Economic Strengthening Intervention to Improve Education and Health-Related Outcomes of School-Going AIDS-Orphaned Children: Lessons from a Randomized Experiment in Southern Uganda.

    Science.gov (United States)

    Ssewamala, Fred M; Karimli, Leyla; Torsten, Neilands; Wang, Julia Shu-Huah; Han, Chang-Keun; Ilic, Vilma; Nabunya, Proscovia

    2016-01-01

    Children comprise the largest proportion of the population in sub-Saharan Africa. Of these, millions are orphaned. Orphanhood increases the likelihood of growing up in poverty, dropping out of school, and becoming infected with HIV. Therefore, programs aimed at securing a healthy developmental trajectory for these orphaned children are desperately needed. We conducted a two-arm cluster-randomized controlled trial to evaluate the effectiveness of a family-level economic strengthening intervention with regard to school attendance, school grades, and self-esteem in AIDS-orphaned adolescents aged 12-16 years from 10 public rural primary schools in southern Uganda. Children were randomly assigned to receive usual care (counseling, school uniforms, school lunch, notebooks, and textbooks), "bolstered" with mentorship from a near-peer (control condition, n = 167), or to receive bolstered usual care plus a family-level economic strengthening intervention in the form of a matched Child Savings Account (Suubi-Maka treatment arm, n = 179). The two groups did not differ at baseline, but 24 months later, children in the Suubi-Maka treatment arm reported significantly better educational outcomes, lower levels of hopelessness, and higher levels of self-concept compared to participants in the control condition. Our study contributes to the ongoing debate on how to address the developmental impacts of the increasing numbers of orphaned and vulnerable children and adolescents in sub-Saharan Africa, especially those affected by HIV/AIDS. Our findings indicate that innovative family-level economic strengthening programs, over and above bolstered usual care that includes psychosocial interventions for young people, may have positive developmental impacts related to education, health, and psychosocial functioning.

  17. The influence of concentrative meditation training on the development of attention networks during early adolescence.

    Science.gov (United States)

    Baijal, Shruti; Jha, Amishi P; Kiyonaga, Anastasia; Singh, Richa; Srinivasan, Narayanan

    2011-01-01

    We investigate if concentrative meditation training (CMT) offered during adolescent development benefits subsystems of attention using a quasi-experimental design. Attentional alerting, orienting, and conflict monitoring were examined using the Attention Network Test (ANT) in 13-15 year old children who received CMT as part of their school curriculum (CMT group: N = 79) vs. those who received no such training (control group: N = 76). Alerting and conflict monitoring, but not orienting, differed between the CMT and control group. Only conflict monitoring demonstrated age-related improvements, with smaller conflict effect scores in older vs. younger participants. The influence of CMT on this system was similar to the influence of developmental maturity, with smaller conflict effects in the CMT vs. control group. To examine if CMT might also bolster conflict-triggered upregulation of attentional control, conflict effects were evaluated as a function of previous trial conflict demands (high conflict vs. low conflict). Smaller current-trial conflict effects were observed when previous conflict was high vs. low, suggesting that similar to adults, when previous conflict was high (vs. low) children in this age-range proactively upregulated control so that subsequent trial performance was benefitted. The magnitude of conflict-triggered control upregulation was not bolstered by CMT but CMT did have an effect for current incongruent trials preceded by congruent trials. Thus, CMT's influence on attention may be tractable and specific; it may bolster attentional alerting, conflict monitoring and reactive control, but does not appear to improve orienting.

  18. US-Pakistan Strategic Partnership: A Track II Dialogue, Sixth Iteration

    Science.gov (United States)

    2012-01-01

    and mutual needs must be managed in order for a recovery to take place. The U.S. agrees that there are sub-national groups operating that can undercut...relations can be mended, and strategic gains can be made on the ground. As explained, “there is no point dancing around these issues, [as the strategic...they would prevent a conventional limited war and bolster Pakistani nuclear muscles . As long as India’s military might continues building to punish

  19. Panic disorder: the psychobiology of external treat and introceptive distress.

    Science.gov (United States)

    Stein, Dan J

    2008-01-01

    Panic disorder seems to be mediated by the neuronal circuitry and neurochemical systems that have evolved to respond to external threatening stimuli. Distant threats activate prefrontal cortex (involved in complex planning of avoidance strategies), while immediate threats activate midbrain structures (involved in fast reflexive behaviors). Panic disorder may, however, also involve more specific interoceptive mechanisms. For example, the association between respiratory dysfunction and panic disorder has bolstered a false suffocation alarm hypothesis. Genetic and environmental contributors to panic disorder are beginning to be delineated. Effective pharmacotherapy and psychotherapy are able to normalize the relevant psychobiology.

  20. Improving HCAHPS Scores with Advances in Digital Radiography.

    Science.gov (United States)

    Matthews, Marianne; Cretella, Gregg; Nicholas, William

    2016-01-01

    The imaging department can be instrumental in contributing to a healthcare facility's ability to succeed in this new era of competition. Advances in DR technology can improve patient perceptions in the imaging department by improving efficiencies and outcomes which, in turn, can ultimately bolster overall HCAHPS scores. Specific areas for improved scores by utilization of DR include nurse communication, doctor communication, pain management, and communication about medication. Value based purchasing brought with it a mandate for hospitals to track key metrics, which requires an investment in time, tools, and human resources. However, this mandate also presents hospitals and imaging departments, with an opportunity to leverage those very metrics to better market their facilities.

  1. CERN and the Wigner Research Centre for Physics inaugurate CERN data centre’s extension in Budapest, Hungary

    CERN Multimedia

    Wigner Research Centre for Physics, Hungary

    2013-01-01

    On 13 June 2013 CERN and the Wigner Research Centre for Physics inaugurated the Hungarian data centre in Budapest, marking the completion of the facility hosting the extension for CERN computing resources. About 500 servers, 20,000 computing cores, and 5.5 Petabytes of storage are already operational at the site. The dedicated and redundant 100 Gbit/s circuits connecting the two sites are functional since February 2013 and are among the first transnational links at this distance. The capacity at Wigner will be remotely managed from CERN, substantially extending the capabilities of the Worldwide LHC Computing Grid (WLCG) Tier-0 activities and bolstering CERN’s infrastructure business continuity.

  2. Mediators of adherence among adults with comorbid diabetes and depression: The role of self-efficacy and social support.

    Science.gov (United States)

    Tovar, Elizabeth; Rayens, Mary Kay; Gokun, Yevgeniya; Clark, Michele

    2015-11-01

    Depression and diabetes have been linked in a variety of ways, and the presence of depression in those with diabetes can negatively affect adherence to care recommendations. A sample of 201 participants with Type 2 Diabetes completed a cross-sectional survey that assessed depressive symptoms, adherence, self-efficacy, social support, and personal characteristics. Multiple regression analysis was used to test whether self-efficacy and social support mediate the relationship between depressive symptoms and adherence. The findings suggest complete mediation via self-efficacy and some types of social support. Intervening to bolster self-efficacy and social support may decrease the negative effect of depression on adherence.

  3. Discovering and exploring ubuntu-language in the dialogue between the Dutch Reformed Church and the Uniting Reformed Church in Southern Africa

    Directory of Open Access Journals (Sweden)

    Lieze Meiring

    2015-06-01

    Full Text Available Discussions with members of the Dutch Reformed Church (DRC and the Uniting Reformed Church in Southern Africa (URCSA in Ohrigstad illustrate the possibilities of ubuntu-language in overcoming racism and prejudice. After proposing a number of meanings and values related to ubuntu, this research explores the role of ubuntu-language � and at times the lack thereof � in the concrete relationship between these two faith communities as an expression of recent South African history. Ubuntu-language seems to offer unique outcomes in this relationship in strengthening identity, unleashing vitality, celebrating diversity, awakening solidarity, revealing humanity, bolstering individualism and enhancing Christianity.

  4. Fronteira, fusão, filme: um toque

    Directory of Open Access Journals (Sweden)

    Tunico Amancio

    2010-12-01

    Full Text Available Considered the first co-production between MERCOSUR countries, "The touch of the Oboe", a film by Claudio MacDowell, suffers from some sort of vagueness that shows off the difficulties of a complete commercial and cultural movie exchange between Brazil's neighbor countries. Even bolstered with powerful traditions, the productive associative project of this cinematic realization emblematizes an economical, symbolical and historical imbalance which still prevails among the countries of the Southern Common Market. The text notes some of these tensions, marked by the relationship between cinema and literature.

  5. Comptia Network+ review guide exam N10-006

    CERN Document Server

    Ferguson, Bill

    2015-01-01

    Be prepared for the Network+ exam CompTIA Network+ Review Guide is your ideal study companion for preparing for the CompTIA Network+ exam (N10-006). This concise review is the perfect companion to the CompTIA Network+ Study Guide and the CompTIA Network+ Deluxe Study Guide, with full exam coverage organized by objective for quick review and reinforcement of key topics. Each of the book's five parts is devoted to a specific domain area of the exam, providing a focused review to bolster areas of weak understanding. You get access to the Sybex test engine, which includes two bonus practice tests

  6. A Change for the Better

    DEFF Research Database (Denmark)

    Rozendal, Arjan; Lim, Eric T. K.; Tan, Chee-Wee

    2015-01-01

    argues for effective change management as a means for organizations to realize business-IT alignment. Findings from a grounded theory study revealed that having clear assessment criteria, promoting information exchange, getting managers to act as role models, expanding the involvement and participation...... of employees in decision making as well as drawing on positive collaborative experiences in the past bolster the success of change initiatives for realizing business-IT alignment. Conversely, pursuing partisan interest at the expense of the organization, speaking different professional languages, displaying...

  7. Effects of food-cue exposure on dieting-related goals: a limitation to counteractive-control theory.

    Science.gov (United States)

    Coelho, Jennifer S; Polivy, Janet; Herman, C Peter; Pliner, Patricia

    2008-09-01

    The present study investigated the effects of exposure to a food cue on the self-reported importance of dieting in those with low, medium, and high levels of dietary restraint. The results indicated that exposure to a food cue bolstered dieting-related goals in those who were low in dietary restraint but had no effect on the importance of dieting-related goals for those with medium or high levels of dietary restraint. The results demonstrate that exposure to temptations may differentially affect self-control processes depending on an individuals' level of dietary restraint.

  8. Bias at the racetrack: effects of individual expertise and task importance on predecision reevaluation of alternatives.

    Science.gov (United States)

    Brownstein, Aaron L; Read, Stephen J; Simon, Dan

    2004-07-01

    These studies were designed to test cognitive dissonance theory's assertion that alternatives are not reevaluated before a choice. Participants viewed information about horses in a simulated race and rated each one's chance of winning three times before placing their bet and once after placing it. It was found that ratings of the chosen horse increased within the predecision period as well as after betting. Predecision bolstering occurred even when participants did not expect to bet, and predecision preference increased with task importance and participant expertise. The findings are attributed to maintenance of consistency throughout a cognitive system.

  9. Metathesis access to monocyclic iminocyclitol-based therapeutic agents

    Directory of Open Access Journals (Sweden)

    Albert Demonceau

    2011-05-01

    Full Text Available By focusing on recent developments on natural and non-natural azasugars (iminocyclitols, this review bolsters the case for the role of olefin metathesis reactions (RCM, CM as key transformations in the multistep syntheses of pyrrolidine-, piperidine- and azepane-based iminocyclitols, as important therapeutic agents against a range of common diseases and as tools for studying metabolic disorders. Considerable improvements brought about by introduction of one or more metathesis steps are outlined, with emphasis on the exquisite steric control and atom-economical outcome of the overall process. The comparative performance of several established metathesis catalysts is also highlighted.

  10. On the dynamics of the three-piece-freight truck

    DEFF Research Database (Denmark)

    Xia, Fujie; True, Hans

    2003-01-01

    Although the three-piece-freight truck is a simple design its mathematical model is very complicated. The model is definitely a nonlinear dynamical system, where the nonlinearities arise from the nonlinear kinematic and dynamical contact relations between wheels and rails, the suspensions...... of the adapters. Due to the clearances between the car body and the side supports on the bolster, the side supports must be modelled as nonlinear dead-band springs. The stick-slip action and the play between elements of the truck makes the dynamical model a structure varying system. We present the dynamical...

  11. "We live on earth : rotating systems" : performance by J. Jarosz (PL) done at the Physics on Stage Festival

    CERN Multimedia

    CERN Audiovisual Service

    2000-01-01

    Part of the Physics on Stage Festival (04-10 November 2000). During this event, the national competion winners, science teachers, science communicators, publishers, top scientists and high-level representatives of the ministries and European organisations will brainstorm future solutions to bolster physics' popularity. The programme will also include spectacular demonstrations of new educational tools; the best will be disseminated over the national TV networks and other media to the European public. A the end of the film, Dutch Performance by The Eindhoven Circus of Physics, Prof. De Waele from the Eindhoven University of Technology

  12. Practice stories in natural resource management continuing professional education: springboards for learning

    DEFF Research Database (Denmark)

    Stummann, Cathy Brown

    2014-01-01

    in supporting professional learning of new concepts. These uses of practice stories are not evident in public natural resource management (NRM) continuing professional education. In light of greater public involvement in NRM practice over the last 20 years, however, the use of practice stories could now......The use of stories from professional experience in continuing professional education has been on the rise in many fields, often aimed at bolstering capacity through sharing professional knowledge and/or supporting reflective practice. Practice stories are also suggested to be beneficial...

  13. Holography and hydrodynamics in small systems

    Science.gov (United States)

    Chesler, Paul M.

    2016-12-01

    Using holographic duality, we present results for the off-center collision of Gaussian wave packets in strongly coupled N = 4 supersymmetric Yang-Mills theory. The wave packets are thin along the collision axis and superficially at least resemble Lorentz contracted colliding protons. The collision results in the formation of a droplet of liquid of size R ∼ 1 /Teff where Teff is the effective temperature, which is the characteristic microscopic scale in strongly coupled plasma. These results demonstrate the applicability of hydrodynamics to microscopically small systems and bolster the notion that hydrodynamics can be applied to heavy-light ion collisions as well as proton-proton collisions.

  14. Standing Fast: German Defensive Doctrine on the Russian Front During World War II; Prewar to March 1943,

    Science.gov (United States)

    1986-09-01

    winall ’v hadsupis(sta.wh * ~ ~ -hich Geirma1n sodiers could pad their bi rts and unifoirms against the cuild. Indoo )rs, s ildieri Hc(u d nm ire eas ii... quality of the infantry junior leaders had noticeably declined.’’" , Strongpoints also bolstered the sagging morale and pugnacity of individual...burden of attack, while lower- quality "trench divisions" were trusted only to hold ground in relatively quiet sectors. That the old Imperial German Army

  15. Financial Planning and Financial Instruments: 2013 in Review, 2014 in Prospect

    Directory of Open Access Journals (Sweden)

    Mark Brimble

    2013-09-01

    Full Text Available The Global Financial Crisis (GFC; changes in regulation; issues in public perception and trust have contributed to a troubled 2013 for financial planners. As financial planning and wealth management providers seek to bolster their professional status, the Financial Planning Education Council’s National Curriculum and Accreditation Framework and ASIC’s minimum training requirements are also a space to watch. In prospect, 2014 will offer opportunities and challenges in the form of a changed government; regulatory changes; accreditation challenges and the hope of the recruitment of strong financial planning and wealth management professionals for the future.

  16. Implementation Of 5S Quality Tool In Manufacturing Company A Case Study

    Directory of Open Access Journals (Sweden)

    Vibhor Kakkar

    2015-02-01

    Full Text Available Abstract 5S system is a technique which maintains the quality of working conditions in the organization. Amongst various available Lean resources 5S is a powerful technique that can bolster objectives of the organization to get continuous improvement in performance and productivity. This paper presents the implementation of 5S in a manufacturing company amp 5S rating system was used to audit all changes in the company which enhanced the efficiency of the workers amp ultimately the productivity of the company is enhanced to 91 .

  17. An evolutionary perspective on zinc uptake by human fungal pathogens†

    Science.gov (United States)

    Wilson, Duncan

    2015-01-01

    The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways. PMID:25652414

  18. Architectural quality: innovation, technological research and design

    Directory of Open Access Journals (Sweden)

    Andrea Campioli

    2011-04-01

    Full Text Available Architectural redevelopment and the revival of the construction sector are conditional on the incentivisation and bolstering of innovation processes. Thus the partial declensions that have been attached to these processes over the last few years have seen research and experimentation being tailored to the spectacularisation of shapes or the hidden performance optimisation of materials and components. Genuine improvement in the quality of architecture and its construction in this day and age depends on the abilities of designers to adopt the entire life cycle of buildings as a reference framework and on the willingness of all those working in the construction supply chain to activate virtuous cooperation.

  19. Colliding shockwaves and hydrodynamics in extreme conditions

    CERN Document Server

    Chesler, Paul M

    2015-01-01

    Using numerical holography, we study the collision of a planar sheet of energy with a bounded localized distribution of energy. The collision, which mimics proton-nucleus collisions, produces a localized lump of debris with transverse size $R \\sim 1/T_{\\rm eff}$ with $T_{\\rm eff}$ the effective temperature, and has large gradients and large transverse flow. Nevertheless, the post-collision evolution is well-described by viscous hydrodynamics. Our results bolster the notion that debris produced in proton-nucleus collisions may be modeled using hydrodynamics.

  20. Insights into the Ukrainian Crisis

    Directory of Open Access Journals (Sweden)

    Costel Daniel Arfire

    2014-05-01

    Full Text Available Political crises are increasingly frequent and devastating not only for the population of a state, but also for the international diplomacy. Such an example is the ongoing Ukrainian crisis. Starting from S. Fink‘s life cycle of a crisis and T.W. Coombs‘s crisis response strategies, I will analyse the evolution of the Ukrainian crisis and the crisis response strategies of three major international actors: Vladimir Putin, Barack Obama and Angela Merkel. The findings of my study will prove that the denial strategy prevails in Putin‘s statement, whereas Obama uses the diminish strategy and Merkel focuses on the bolstering strategy.

  1. Anthropogeny and Intellectual Evolution%人类起源与智能进化

    Institute of Scientific and Technical Information of China (English)

    吕宝忠

    2012-01-01

    The long evolutionary way for human can be traced back to about 5 million years ago, in which two "missing links", Ardipi-thecus ramidus and Australopithecus sediba , have been validated. There are two conflicted hypotheses, "out of Africa" and multire-gional origins. At present, the mixture of both hypotheses seems to be more valuable according to Neanderthal and Denisovan genome draft and other data. The ultimate explanation for being human is focused on the culture-making brain, especially in the cerebral hemisphere asymmetry, that bolsters the framework for 4 graded languages and 3 types of world.

  2. An annotated bibliography for the testifying child and adolescent psychiatrist.

    Science.gov (United States)

    Ash, Peter; O'Leary, Paul J

    2011-07-01

    To persuade a fact finder that a forensic opinion has a scientific basis, it is often useful to cite professional literature that supports one's opinions or procedures. If the admissibility of one's opinion is challenged in a Daubert hearing, citing literature is almost always required to support the claim that the expert's opinion relies on scientific facts or proceeds from scientific methodology. This annotated bibliography provides a sampling of articles that may be useful in bolstering testimony. The sample selected here is not comprehensive, but provides examples of literature that may be cited by forensic child and adolescent psychiatric experts.

  3. A neurodynamic model of the attentional blink.

    Science.gov (United States)

    Fragopanagos, Nickolaos; Kockelkoren, Stephanus; Taylor, John G

    2005-08-01

    A brain-based neural model of attention is used to simulate results for the 'attentional blink', observed when a subject is exposed to a rapid stream of stimuli and required to monitor for two successive targets in the stream. The 'blink' occurs when the time between the first and second targets is 200-500 ms, when there is reduced accuracy for report of the second target. The model gives a qualitative explanation of the phenomenon, especially of how attention is bolstered, during the processing to report of a given stimulus, in order to defend reportable information from attack by distracters.

  4. P. W. Botha and the Space Research Corporation: Clandestine Operations and the Rise of a New Order in South Africa.

    Science.gov (United States)

    1986-01-01

    from SRC. The SRC caper brought together the intelligence community, under the direction of the DMI, and ARMSCOR. Anthony Sampson, an expert on...in the SRC caper could have bolstered Vorster’s sagging political fortunes. Unfortunately for Vorster and his hand-picKed successor, the Information...NY: Stein and Day, 19B4) P. 26S. 24. Winter, p. 36. 25. Winter, Pp. 36-37, West, p. 2B6. 26. Winter, Pp. 38, 81. 27. Barbara Carr, Spy in the Sun: The

  5. Life stress, social support, and self-esteem in an elderly population.

    Science.gov (United States)

    Krause, N

    1987-12-01

    Findings in previous studies of the stress-buffering properties of social support have been erratic. This study suggests that at least part of the reason for those inconclusive findings may be that researchers are using oversimplified models of the stress process and limited statistical approaches to assess the effects. The findings in this study indicate that social support (a) helps to reduce the deleterious effects of stress on emotional disorder primarily by bolstering the self-esteem of older adults and (b) affects psychological well-being only indirectly through self-esteem. Two distinct approaches to the statistical estimation of stress-buffering effects are also examined.

  6. Listening above the Din: The Potential of Language in Organizational Research

    Directory of Open Access Journals (Sweden)

    Steven A. Murphy

    2006-06-01

    Full Text Available In this article, the authors critically examine the use of language in organizational research. A literature review of management articles since the 1950s reveals that qualitative research is increasingly using quantitative methods to bolster arguments and argue for increased reliability. The authors found relatively few articles that included any analysis of the language or context embedded in any empirical study. They offer suggestions for the creation of alternative research paradigms that incorporate language and provide a voice to previously muted methods and voices.

  7. Dynamic electromagnetic metamaterials

    Directory of Open Access Journals (Sweden)

    Kebin Fan

    2015-01-01

    Full Text Available Electromagnetic metamaterials are designer materials made from ‘artificial atoms’ which provide unprecedented control over light matter interactions. Metamaterials are fashioned to yield a specific response to the electric and magnetic components of light and have realized a multitude of exotic properties difficult to achieve with natural materials. Having matured over the last decade and a half, researchers now look toward realizing applications of metamaterials. The ability to dynamically control novel responses exhibited by electromagnetic metamaterials would bolster this quest thus ushering in the next revolution in materials.

  8. Differences in academic performance at school depending on handedness: matter for neuropathology?

    Science.gov (United States)

    Williams, S M

    1987-12-01

    Two studies found that left-handed children had significantly poorer academic records than did right-handed children, though the effect was small. Study 1 provided evidence that, for some academic disciplines, the important difference appeared to be between those children whose family history of handedness was concordant with their own handedness and those children whose family history of handedness was discordant with their own handedness. The inclusion of gender in asymmetry research was bolstered by Study 2. When predicting idiosyncrasies in left-handers' cognitive performance, it should be borne in mind that left-handers form a minority group as well as a neurologically distinct one.

  9. New horizons mapping of Europa and Ganymede.

    Science.gov (United States)

    Grundy, W M; Buratti, B J; Cheng, A F; Emery, J P; Lunsford, A; McKinnon, W B; Moore, J M; Newman, S F; Olkin, C B; Reuter, D C; Schenk, P M; Spencer, J R; Stern, S A; Throop, H B; Weaver, H A

    2007-10-12

    The New Horizons spacecraft observed Jupiter's icy satellites Europa and Ganymede during its flyby in February and March 2007 at visible and infrared wavelengths. Infrared spectral images map H2O ice absorption and hydrated contaminants, bolstering the case for an exogenous source of Europa's "non-ice" surface material and filling large gaps in compositional maps of Ganymede's Jupiter-facing hemisphere. Visual wavelength images of Europa extend knowledge of its global pattern of arcuate troughs and show that its surface scatters light more isotropically than other icy satellites.

  10. Joomla! 25 Beginner's Guide

    CERN Document Server

    Tiggeler, Eric

    2012-01-01

    Written with a fast-paced but friendly and engaging approach, this Packt Beginner's guide is designed to be placed alongside the computer as your guide and mentor. Step-by-step tutorials are bolstered by explanations of the reasoning behind what you are doing. You will quickly pick up the necessary skills, tips, and tricks for building a successful Joomla! website. This book is written for beginners to website design. By the end of the book you will have built a complete custom content managed website, and be ready to build any kind of website.

  11. Hope and fatigue in chronic illness: The role of perceived stress.

    Science.gov (United States)

    Hirsch, Jameson K; Sirois, Fuschia M

    2016-04-01

    Fatigue is a debilitating symptom of chronic illness that is deleteriously affected by perceived stress, a process particularly relevant to inflammatory disease. Hopefulness, a goal-based motivational construct, may beneficially influence stress and fatigue, yet little research has examined these associations. We assessed the relation between hope and fatigue, and the mediating effect of stress, in individuals with fibromyalgia, arthritis, and inflammatory bowel disease. Covarying age, sex, and pain, stress partially mediated the association between hope and fatigue; those with greater hope reported less stress and consequent fatigue. Therapeutically, bolstering hope may allow proactive management of stressors, resulting in less fatigue.

  12. Longitudinal analysis of virtual community perceptions of cohesion: The role of cooperation, communication, and competition.

    Science.gov (United States)

    Lyles, Annmarie A; Loomis, Colleen; Mama, Scherezade K; Siddiqi, Sameer; Lee, Rebecca E

    2016-09-14

    Online, virtual group interactions may help adherence to health promotion programs. The purpose of this study was to explore longitudinal relationships among dimensions of group cohesion and group-interaction variables to inform and improve group-based strategies within programs aimed at promoting physical activity in virtual communities. In all, 56 online virtual users completed a group dynamics-based physical activity promotion intervention and assessments of group cohesion and group interaction at baseline and 4 weeks. Friendly competition and cooperation were consistently strong predictors of cohesion. Facilitating a sense of friendly competition and cooperation may increase engagement in physical activity programs by bolstering group cohesion.

  13. Twelve Traditional Chinese Paths to Good Health

    Institute of Scientific and Technical Information of China (English)

    JANE SHAW

    1994-01-01

    THESE 12 traditional Chinese practices were devised by our ancestors to maintain good health and are key to longevity. To bolster your health, try the following: 1. Move your eyes often. Ancient people called this exercise "yunjing" and believed moving the eyes could eliminate cataracts and nebulas and adjust myopia and farsightedness. First move the eyes from left to right and vice versa, then up and down and vice versa, 15 times each direction. Close your eyes tightly for a moment and then open them wide.

  14. Prolene (mesh bulbourethral sling in male incontinence

    Directory of Open Access Journals (Sweden)

    Rakesh Kapoor

    2007-01-01

    Full Text Available Objective : We present our preliminary results of bulbar urethral sling (single bolster in treatment of postprostatectomy urinary incontinence (PPUI. Materials and Methods: From May 2003 to June 2005, six patients with postprostatectomy urinary incontinence (transurethral resection of prostate in five patients and after open prostatectomy in one patient underwent prolene mesh bulbar urethral sling surgery. Preoperative evaluation included physical examination, neurological assessment, stress cystogram and urethrocystoscopy. Urodynamic evaluation was done in all patients for abdominal leak point pressure and ruling out bladder pathology. Results : Urodynamic studies did not demonstrate bladder instability in any patient. Mean abdominal leak point pressure was 43cm of water (range 26-80 cm of water. Mean duration of hospital stay was 3.2 days. Follow-up ranged from 6-22 months. Four patients out of six patients were completely dry till their last follow-up. One patient developed mild stress incontinence after one year of the surgery and required use of one to two pads per day. Mean pad use after surgery was 0.6 pads per day in comparison to mean pad usage of 6.4 pads per day preoperatively. One patient was over-continent after the procedure and required clean intermittent catheterization till last follow-up (six months. Mean cost of the procedure was $ 350+15. Conclusion: Prolene bulbar urethral sling (single bolster is an economically effective option in patients with postprostatectomy urinary incontinence.

  15. Activism as a Heroic Quest for Symbolic Immortality: An Existential Perspective on Collective Action

    Directory of Open Access Journals (Sweden)

    Julia Elad-Strenger

    2016-03-01

    Full Text Available Excellent research exists on the conditions that generate political and social activism. Yet a central issue has remained perplexing: how does the personal need to stand out as unique and heroic interact with the concern for the positive image of the group, and the desire to protect and bolster its status, goals and shared values, in propelling collective action? Inspired by existential theory and research, this paper proposes an existential perspective on activism that identifies the human desire for a sense of meaning and significance as an important motivation underlying individuals' choice to engage in collective action. This study outlines an integrative model of collective action, combining insights from existential psychology with insights from the social identity perspective, to bridge together needs and concerns associated with both personal identity and group identity into a single model of collective action through the concept of death-anxiety buffering mechanisms. This model suggests that collective action is an effective means to satisfy existential needs through bolstering and protecting group interests and values on the one hand, and realizing the activist's heroism project on the other. Suggestions for future research are discussed.

  16. 大功率交流电力机车枕梁簧座焊接工艺优化%Welding Technics Improving to the Spring Pedestal of High - power AC Electric Locomotive

    Institute of Scientific and Technical Information of China (English)

    贺煣; 许立勇; 谷祥帅

    2013-01-01

    This paper presents the product structure ,welding quality requirement ,assembling and welding scheme of the spring pedestal which used in the bolster beam of High - power AC Transmission Electric Locomotive .According to the analysis of the welding fault which caused by manual welding method and robot -welding method ,improved the welding technics and established an effective solution ,finally ensures the welding quality and heightens the manufacture efficiency of the spring pedestal which used in the bolster beam .%  文章介绍了大功率交流传动电力机车枕梁簧座产品结构、焊接质量要求、装配和焊接方案,对焊接缺陷进行了系统分析,制定了有效的解决措施,保证了枕梁簧座的焊接质量,提高了生产效率。

  17. The Concept of Alliance as an Image and Positioning Instrument for Institutions of Higher Learning

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Alcántar Enríquez

    2004-05-01

    Full Text Available The present work provides a foundation for the concept of alliance which includes the ability of this to foster the university’s societal position as based on public perception of the institution. Accordingly, the work briefly addresses the development of the university’s collaboration with the productive sector, and emphasizes the need for institutions of higher learning to consider as well, those social sectors (including the government outside the realm of industry or technological expansion. The study concludes by affirming that alliance can become an effective instrument for promoting the university. It is therefore necessary to research the social perception of the university as a means of bolstering its relevance.

  18. Construal Level and Social Exclusion: Concrete Thinking Impedes Recovery From Social Exclusion.

    Science.gov (United States)

    Pfundmair, Michaela; Lermer, Eva; Frey, Dieter; Aydin, Nilüfer

    2015-01-01

    Social exclusion is a painful experience. Recent research has shown, however, that coping with exclusion can be facilitated by favorable conditions. In the current research, we investigated whether construal level affects recovery from social exclusion. We hypothesized that an abstract vs. concrete mindset would moderate coping with exclusion. Indeed, lower compared to higher concrete thinking (Study 1) and abstract compared to concrete thinking (Study 2) bolstered the basic need of belonging when excluded. Priming of abstract thinking, moreover, increased participants' sense of belonging both in response to exclusion and inclusion relative to no priming (Study 3). Our results are the first to establish a relationship between construal level and social exclusion, thereby suggesting an alleviating "abstraction discount" effect for the consequences of social exclusion.

  19. Dawr al-Sulṭān Zayn al-‘Ābidīn fī Nashr al-Islām fī Sulṭānah al-Tarnātī fī al-Qarn al-Rābī’ ‘Ashr al-Mīlādīyah

    Directory of Open Access Journals (Sweden)

    Bunyamin Marasabessy

    2006-12-01

    Full Text Available This article looks closely at the process of the growth and development of Islam in Malaku, focusing on the role of one of the rulers of Tarnate, Sultan Zainal Abidin, in this process. As the oldest son of the previous ruler, Kolano Marhum, Zainal Abidin was the logical choice to become the 19th Sultan of the Ternate Kingdom; this was bolstered by the fact that he inherited all of his father's good character traits. Zainal Abidin ruled the Kingdom of Ternate from 1468 until1500. The northern area of Maluku (Ternate-Halamahera is a region which is rich in spices. It was this that brought merchants on masse from the Middle East to Maluku. Further to their business activities, the Arab merchants also carried out dakwah activities.Copyright (c 2014 by SDI. All right reserved.DOI: 10.15408/sdi.v13i3.562

  20. The role of professional and team commitment in nurse-physician collaboration: A dual identity model perspective.

    Science.gov (United States)

    Caricati, Luca; Guberti, Monica; Borgognoni, Patrizia; Prandi, Carmen; Spaggiari, Ivana; Vezzani, Emanuela; Iemmi, Marina

    2015-01-01

    Nurse-physician collaboration involves healthcare operators from different professions working together. The dual identity model predicts that nurse-physician interprofessional collaboration could improve if these operators feel they belong to both their professional category and care unit. This study tested this prediction by analyzing the effect of professional and team commitments on interprofessional collaboration between nurses and physicians in a hospital based in Northern Italy. A cross-section questionnaire survey was administered to 270 nurses and 95 physicians. Results indicate that interprofessional collaboration is positively affected by team commitment, while professional commitment had no effect. In accordance with the dual identity model, results indicate that interprofessional collaboration is higher when: (i) both professional and team commitment is high, and (ii) when team commitment is high and professional commitment is low. These results support dual identity model predictions and suggest that interprofessional collaboration can be increased by bolstering both team and professional commitment of nurses and physicians.

  1. MARKET WATCH

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The China Banking Regulatory Commission has kickstarted a pilot program to bolster consumer finance companies. This marks a step forward in the economic shift toward consumptions. In June, China trimmed a record net $25.1 billion in holdings from U.S. Treasury securities on concerns over the value of U.S. dollar assets. Air China Ltd., one of the country’s big three carriers, meanwhile, plans to raise its stake in Cathay Pacific Airways Ltd. to nearly 30 percent. China’s foreign direct investment inflows, at the same time, continued to decline in July, but its long-term prospects remain intact. The China Investment Corp. generated $23.1 billion in net profits last year and its return on registered capital was 6.8 percent.

  2. 酯硬化水玻璃砂工艺和设备的应用%Applications of Process and Device for Ester Cured Sodium Silicate Sand

    Institute of Scientific and Technical Information of China (English)

    许文彪

    2012-01-01

    为根据生产铁路货车摇枕、侧架、车钩等铸钢件的要求,设计建成了酯硬化水玻璃生产线.试生产表明:酯硬化水玻璃工艺和建成的高速造型圈、高速制芯圈和砂再生系统可以满足铸钢件生产的需要.%In accordance with the requirements of the production of railway truck steel castings of bolster, side frame and coupler, a production line of ester-hardened sodium silicate sand was designed and built. Trial production show that the technology of ester-hardened sodium silicate sand and the built high-speed modeling circle, high-speed core-making ring and sand reclamation system can meet the needs of the production of steel castings.

  3. Smartphones in Surgery

    Directory of Open Access Journals (Sweden)

    Ara A. Salibian

    2011-01-01

    Full Text Available Smartphones have the capability of enhancing many aspects of the continuum of surgical care by providing an efficient means of multimedia communication among surgeons and healthcare personnel. The ability for mobile Internet and email access, along with features such as built-in cameras and video calling, allow surgeons to rapidly access, send and receive patient information without being restricted by issues of connectivity. Smartphones create an unrestricted network of data sharing, improving the flexibility of patient consultation, timeliness of preoperative preparation, efficiency of post-operative care and the effectiveness of a surgical team. Furthermore, smartphones provide mobile access to a multitude of surgical resources to bolster continued surgical education. This article presents a review of the current literature on the utilizations of smartphones in surgery, discusses their benefits and limitations, and addresses the possibility of incorporating smartphones into the protocol of surgical care.

  4. Secure versus fragile high self-esteem as a predictor of verbal defensiveness: converging findings across three different markers.

    Science.gov (United States)

    Kernis, Michael H; Lakey, Chad E; Heppner, Whitney L

    2008-06-01

    Why is it that many individuals verbally rationalize and distort self-esteem threatening information? We examined whether such verbal defensiveness (Feldman Barrett, Williams, & Fong, 2002) differs as a function of whether individuals' high self-esteem is secure or fragile. Our findings indicated that individuals whose self-esteem was stable, not contingent, or congruent with high implicit self-esteem exhibited especially low amounts of verbal defensiveness. In contrast, verbal defensiveness was considerably higher when individuals' high self-esteem was unstable, contingent, or paired with discrepant low implicit self-esteem. Discussion centers on why the possession of well-anchored and secure high self-esteem obviates defensiveness directed toward enhancing, maintaining, or bolstering feelings of self-worth.

  5. Tuning them in versus turning them on: how do we interest students in working with older adults?

    Science.gov (United States)

    Gross, Patricia E; Eshbaugh, Elaine M

    2011-01-01

    As a nation, we face a shortage of individuals to serve our aging population. Therefore, the recruitment of undergraduate students into gerontology programs is an important, although challenging task. The purpose of this study was to determine if students who do not choose to major in gerontology do so because they simply are unaware of the opportunities or because they are uninterested. College students who were not gerontology majors (N = 226) were surveyed to determine whether they were aware of a gerontology major at their university, whether they could define gerontology, and their reasons for not pursuing gerontology. Results suggest that a lack of awareness, rather than a lack of interest, may be responsible for the challenges of recruiting college students into the field of gerontology. This implies that the most efficient path to bolstering our gerontology workforce may be to make students aware of the diverse and rewarding career opportunities in the field of aging.

  6. "To Bluff like a Man or Fold like a Girl?" – Gender Biased Deceptive Behavior in Online Poker

    Science.gov (United States)

    Palomäki, Jussi; Yan, Jeff; Modic, David; Laakasuo, Michael

    2016-01-01

    Evolutionary psychology suggests that men are more likely than women to deceive to bolster their status and influence. Also gender perception influences deceptive behavior, which is linked to pervasive gender stereotypes: women are typically viewed as weaker and more gullible than men. We assessed bluffing in an online experiment (N = 502), where participants made decisions to bluff or not in simulated poker tasks against opponents represented by avatars. Participants bluffed on average 6% more frequently at poker tables with female-only avatars than at tables with male-only or gender mixed avatars—a highly significant effect in games involving repeated decisions. Nonetheless, participants did not believe the avatar genders affected their decisions. Males bluffed 13% more frequently than females. Unlike most economic games employed exclusively in research contexts, online poker is played for money by tens of millions of people worldwide. Thus, gender effects in bluffing have significant monetary consequences for poker players. PMID:27383472

  7. Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?

    Science.gov (United States)

    Hemingway, Janet; Shretta, Rima; Wells, Timothy N C; Bell, David; Djimdé, Abdoulaye A; Achee, Nicole; Qi, Gao

    2016-03-01

    Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and prevent malaria, including innovative diagnostics, medicines, vaccines, vector control products, and improved mechanisms for surveillance and response. There are at least 25 projects in the global malaria vaccine pipeline, as well as 47 medicines and 13 vector control products. In addition, there are several next-generation diagnostic tools and reference methods currently in development, with many expected to be introduced in the next decade. The development and adoption of these tools, bolstered by strategies that ensure rapid uptake in target populations, intensified mechanisms for information management, surveillance, and response, and continued financial and political commitment are all essential to achieving global eradication.

  8. DECREASING INDIRECT FISCAL PRESSURE – ESSENTIAL TOOL FOR COMPETITIVENESS ENHANCING OF ROMANIA’S TOURISM SECTOR

    Directory of Open Access Journals (Sweden)

    Maria Loredana POPESCU

    2015-07-01

    Full Text Available Present condition of Romanian economy is (still! bad enough, given the yet existent (aftereffects of world economic and financial crisis, so that this economy badly needs bolstering up in any manner whatsoever; considering this perspective, and Romania’s tourism potential, Romania’s tourism sector can become a hub of/for economic recovery. But, in order to do this, Romania’s policymakers need not lose from sight Romania’s long term objectives, whilst trying to attain (just the short term ones. For the latter’ achievement fiscal policy is a main tool, but if this tool is used in extremis tourism sector will definitely suffer. On the other hand, it is also true fiscal policy, if used wisely, is more than able to be an essential tool with which one can enhance competitiveness of Romania’s tourism sector.

  9. EXPORTS, FOREIGN DIRECT INVESTMENT AND ECONOMIC GROWTH: EMPIRICAL EVIDENCE FROM MALAYSIA (1971-2013

    Directory of Open Access Journals (Sweden)

    Muhammad Haseeb

    2014-01-01

    Full Text Available The main objective of this study is to empirically investigate the relationship between exports, Foreign Direct Investment (FDI and the economic growth in Malaysia. Records of annual time series data from the year 1971 till 2013 have been utilized for this purpose. Upon testing the data for stationarity, the Auto Regressive Distributed Lag (ARDL model has been applied for the purpose of empirical investigation. The empirical results indicate that the productivity factor and externality effect of exports on the non-export sector are found to be statistically, positively significant, with the exports also having a positive impact on the economic growth and FDI of the country. The results support Exports Led Growth (ELG and FDI-Led economic Growth (FLG in Malaysia. The finding further suggests that Malaysia should continuous pursue exports promotion and a liberal investment economic policy in order to maintain and bolster overall economic growth.

  10. From Slash-and-burn to Disk Ploughing: The Land Policy and Tractors Behind Erosion and Forest Pioneer Farming in Southern Xayabury Province (Laos

    Directory of Open Access Journals (Sweden)

    Marc Dufumier

    2013-02-01

    Full Text Available Bordering Thailand, the southern part of Xayabury province is engaged in international trade and has experienced agricultural growth like nowhere else in Laos. The rapid transformation from manual slash-and-burn agriculture to mechanized, chemical-based cropping systems is often cited by Laotian authorities as a model of development. But a careful study of changes underway indicates that the reality is far less encouraging than it would appear at first. If many farmers have indeed bolstered their incomes over the last twenty years, it is no less true that some of the poorest peasants have become increasingly poorer and that the new techniques cause serious erosion, as they have not been able to prevent the expansion of cultivated areas on sloping lands.

  11. Lesbian, Gay, and Bisexual Identity as a Moderator of Relationship Functioning After Sexual Assault.

    Science.gov (United States)

    Gemberling, Tess M; Cramer, Robert J; Miller, Rowland S; Stroud, Caroline H; Noland, Ramona M; Graham, James

    2015-12-01

    Sexual assault is unfortunately common, especially among lesbian, gay, and bisexual (LGB) individuals. Yet, the associations of such victimization have not yet been extensively established in the areas of sexual identity and romantic relationship functioning. Accordingly, the present study examined the associations between lifetime sexual assault, LGB identity, and romantic relationship functioning in a sample of 336 LGB individuals. A history of sexual assault was associated with attachment anxiety and several sexual identity components (i.e., higher levels of acceptance concerns, identity uncertainty, internalized homonegativity, and identity superiority). Furthermore, an association of sexual assault and attachment avoidance was moderated by internalized homonegativity. Finally, a more secure LGB identity was associated with healthier romantic relationship functioning. Collectively, these findings are applicable to services for LGB sexual assault victims, suggesting the incorporation of treatment that bolsters LGB identity and couple functioning. Limitations and future directions are discussed.

  12. Information Literacy on the Web: How College Students Use Visual and Textual Cues to Assess Credibility on Health Websites

    Directory of Open Access Journals (Sweden)

    Katrina L. Pariera

    2012-12-01

    Full Text Available One of the most important literacy skills in today’s information society is the ability to determine the credibility of online information. Users sort through a staggering number of websites while discerning which will provide satisfactory information. In this study, 70 college students assessed the credibility of health websites with a low and high design quality, in either low or high credibility groups. The study’s purpose was to understand if students relied more on textual or visual cues in determining credibility, and to understand if this affected their recall of those cues later. The results indicate that when viewing a high credibility website, high design quality will bolster the credibility perception, but design quality will not compensate for a low credibility website. The recall test also indicated that credibility does impact the participants’ recall of visual and textual cues. Implications are discussed in light of the Elaboration Likelihood Model.

  13. Language exposure facilitates talker learning prior to language comprehension, even in adults.

    Science.gov (United States)

    Orena, Adriel John; Theodore, Rachel M; Polka, Linda

    2015-10-01

    Adults show a native language advantage for talker identification, which has been interpreted as evidence that phonological knowledge mediates talker learning. However, infants also show a native language benefit for talker discrimination, suggesting that sensitivity to linguistic structure due to systematic language exposure promotes talker learning, even in the absence of functional phonological knowledge or language comprehension. We tested this hypothesis by comparing two groups of English-monolingual adults on their ability to learn English and French voices. One group resided in Montréal with regular exposure to spoken French; the other resided in Storrs, Connecticut and did not have French exposure. Montréal residents showed faster learning and better retention for the French voices compared to their Storrs-residing peers. These findings demonstrate that systematic exposure to a foreign language bolsters talker learning in that language, expanding the gradient effect of language experience on talker learning to perceptual learning that precedes sentence comprehension.

  14. Retainment incentives in three rural practice settings: variations in job satisfaction among staff registered nurses.

    Science.gov (United States)

    Stratton, T D; Dunkin, J W; Juhl, N; Geller, J M

    1995-05-01

    Researchers have demonstrated repeatedly the importance of the relationship linking job satisfaction to employee retention. In rural areas of the country, where a persistent maldistribution of nurses continues to hamper health care delivery, the potential benefits of bolstering retention via enhancements in job satisfaction are of utmost utility to administrators and providers alike. Data were gathered from a multistate survey of registered nurses (RNs) practicing in rural hospitals, skilled nursing facilities, and community/public health settings (N = 1,647; response rate = 40.3%). The investigators found that the use of tuition reimbursement corresponded significantly with increased levels of job satisfaction among nurses in all three practice environments, as did day care services for nurses in acute care settings. Also, among hospital-based RNs, level of nursing education was found to be a significant factor in the relationship between tuition reimbursement and job satisfaction, with the highest level occurring among diploma-prepared nurses.

  15. The B P Deepwater Horizon disaster - why it shouldn't happen off Norway; Gulf of Mexico (GoM) oil spill

    Energy Technology Data Exchange (ETDEWEB)

    Stoichevski, William

    2010-07-01

    As Europe holidayed and the Gulf of Mexico (GoM) filled with oil from the blown Macondo well, Norway's Petroleum Inspection Authority (PSA) worked full tilt to bolster drilling safety with lessons from the Deepwater Horizon disaster. Known for approving the high-pressure, high-temperature wells of the Norwegian Sea, the PSA said it was already practicing 'all but five' of 21 new offshore safety recommendations from the office of US Secretary of the Interior Ken Salazar. Indeed, Salazar and the US President's press chief said out loud that America would look to the offshore safety model in Norway, where PSA inspectors horrified by Macondo were getting tougher on drilling and well design. Local oil spill planning was already on the right track. (Author)

  16. Clinical Experience in TCM Treatment of Insomnia

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Insomnia is a sleeping disorder that affects 1 in 10 Americans and around 50% of the seniors. It is often more prevalent in women. Since September 11, 2005 these estimations have increased. Insomnia can affect not only your energy level and mood, but your health as well because sleep helps bolster your immune system. Insomnia is characterized by: 1) difficulty in falling asleep; 2) waking up frequently during the night with difficulty of returning to sleep; 3) waking up too early in the morning; and 4) with unrefreshing sleep, the patient has a low spirit, palpation, poor memory, viscera function disorder. All these seriously affect the patient's life and work. The following is an account of the authors' clinical TCM experience in treating insomnia.

  17. Therapeutic Robotics: A Technology Push: Stroke rehabilitation is being aided by robots that guide movement of shoulders and elbows, wrists, hands, arms and ankles to significantly improve recovery of patients.

    Science.gov (United States)

    Krebs, Hermano Igo; Hogan, Neville

    2006-09-01

    In this paper, we present a retrospective and chronological review of our efforts to revolutionize the way physical medicine is practiced by developing and deploying therapeutic robots. We present a sample of our clinical results with well over 300 stroke patients, both inpatients and outpatients, proving that movement therapy has a measurable and significant impact on recovery following brain injury. Bolstered by this result, we embarked on a two-pronged approach: 1) to determine what constitutes best therapy practice and 2) to develop additional therapeutic robots. We review our robots developed over the past 15 years and their unique characteristics. All are configured both to deliver reproducible therapy but also to measure outcomes with minimal encumbrance, thus providing critical measurement tools to help unravel the key question posed under the first prong: what constitutes "best practice"? We believe that a "gym" of robots like these will become a central feature of physical medicine and the rehabilitation clinic within the next ten years.

  18. Moving From Digitalization to Digitization in Cardiovascular Care: Why Is it Important, and What Could it Mean for Patients and Providers?

    Science.gov (United States)

    Steinhubl, Steven R; Topol, Eric J

    2015-09-29

    So far, the digitization of health care is best exemplified by electronic medical records, which have been far from favorably or uniformly accepted. However, properly implemented digitization can enable better patient outcomes, improve convenience, potentially lower healthcare costs, and possibly lead to much greater physician satisfaction. Precision (also known as personalized or individualized) medicine is frequently discussed today, but, in reality, it is what physicians have attempted to do as best they could for millennia. But now we have new tools that can begin to give us a much more high-definition view of our patients; from affordable and rapid genetic testing to wearable sensors that track a wide range of important physiologic parameters continuously. Although seemingly counterintuitive, the digitization of health care can also markedly improve the physician-patient relationship, allowing more time for human interaction when care is bolstered by digital technologies that better individualize diagnostics and treatments.

  19. Replicating Cardiovascular Condition-Birth Month Associations

    Science.gov (United States)

    Li, Li; Boland, Mary Regina; Miotto, Riccardo; Tatonetti, Nicholas P.; Dudley, Joel T.

    2016-01-01

    Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms. PMID:27624541

  20. Spliced

    DEFF Research Database (Denmark)

    Addison, Courtney Page

    2016-01-01

    Human gene therapy (HGT) aims to cure disease by inserting or editing the DNA of patients with genetic conditions. Since foundational genetic techniques came into use in the 1970s, the field has developed to the point that now three therapies have market approval, and over 1800 clinical trials have...... been initiated. In this article I present a brief history of HGT, showing how the ethical and practical viability of the field was achieved by key scientific and regulatory actors. These parties carefully articulated gene therapy’s scope, limiting it to therapeutic interventions on somatic cells......, and cultivated alliances and divisions that bolstered the field’s legitimacy. At times these measures faltered, and then practitioners and sometimes patients would invoke an ethical imperative, posing gene therapy as the best solution to life and death problems. I suggest that we consider how boundary...

  1. From Awareness to Cultural Agency: EFL Colombian Student Teachers’ Travelling Abroad Experiences

    Directory of Open Access Journals (Sweden)

    John Jairo Viafara González

    2015-01-01

    Full Text Available Colombian English as a foreign language student teachers’ opportunities to grow as educators through international sojourns do not usually subsume the traditional study and residence abroad goal. This was the case for our participants who engaged mainly in working abroad with study being ancillary. Fifty student teachers from two public universities reported how their international sojourn bolstered their intercultural learning. Three different programs, disconnected from participants’ academic institutions, became vehicles for their experiences abroad. Surveys and interviews reveal that participants’ origin, selected programs, and contextual circumstances influenced their intercultural learning. As a result, intercultural development gravitated towards awareness of intercultural patterns, critical reading of culture, and pre-service teachers’ repositioning to build cultural agency. Implications suggest the need to connect traveling abroad programs to undergraduate curricula.

  2. Claudia Quinta (Pro Caelio 34 and an altar to Magna Mater

    Directory of Open Access Journals (Sweden)

    Eleanor Winsor Leach

    2010-11-01

    Full Text Available Among the items of sculpture from the Capitoline collection now housed in the Museum of the Power Station Montemartini is a marble relief altar of the Claudian Period (E. Simon's dating dedicated to the mater deorum and the navis salvia and depicting the arrival of the goddess Cybele at Rome by ship. The dedicator is one Claudia Syntyche and the sculpture alludes to the legends attached to a much honored woman of the Claudian family whom Cicero, in his oration pro Caelio brought on stage in a cameo appearance to bolster his case against the controversial contemporary woman Clodia Metelli as one of the accusers of his client M. Caelius Rufus. This paper will consider questions raised by the iconography of the altar with reference to the development of Claudia's legend in Roman mythology and subsequently ask who was this Claudia the dedicator and why did she choose Magna Mater for her vow?

  3. Commentary on Alcorn & Massé: troubling pedagogy

    Directory of Open Access Journals (Sweden)

    Michael O’Loughlin

    2011-12-01

    Full Text Available Responding to papers by Michelle Massé and Marshall Alcorn, I begin with an argument for the need to recognize ignorance as performative rather than merely as illustrative of student resistance in some pathological sense. I then explore the Lacanian notion that teachers develop imaginary suppositions about the lack in their students, and that these suppositions support rescue fantasies among teachers that are related to bolstering their own unconscious need for narcissistic gratification and love. I conclude by showing how these ideas resonate with my own autobiographical history as a teacher, as well as with key ideas in the two papers under discussion, and I commend both authors for opening up a valuable discussion of teaching as an “impossible profession”.

  4. Intrathoracic glial implants in a child with gliomatosis peritonei.

    Science.gov (United States)

    Lipskar, Aaron M; Rothstein, David H; Soffer, Samuel Z; Edelman, Morris; Glick, Richard D

    2009-09-01

    Glial peritoneal implants, commonly referred to as gliomatosis peritonei, are an occasional feature of ovarian teratomas. They are benign nodules of mature glial tissue and usually do not adversely affect outcome. We present the case of a 12-year-old girl who underwent excision of an immature ovarian teratoma, along with biopsies of multiple glial peritoneal implants. She also had a 2-cm right-sided pleural mass, which turned out to be normal glial tissue that was histologically indistinguishable from the peritoneal glial tissue. Pleural gliomatosis has not been described in the literature. The pathophysiology of gliomatosis peritonei was originally thought to be the direct extrusion or lymphatic spread of glial cells from the associated teratoma, although it has been postulated that the glial implants may instead be the result of pluripotent Mullerian stem cells that undergo metaplasia. This report provides evidence to bolster the metaplastic theory.

  5. Does the processing fluency of a syllabus affect the forecasted grade and course difficulty?

    Science.gov (United States)

    Guenther, R Kim

    2012-06-01

    Processing fluency is known to affect a variety of cognitive assessments, but most research has not examined such effects in the context of a real-life experience. In the first experiment, college students, enrolled in either a statistics or cognitive psychology course, read a course syllabus which varied in the clarity of its font and frequency of its vocabulary. Based on the syllabus, students then forecasted their final course grade and the course's difficulty. Despite methodological similarity to other fluency experiments and adequate statistical power, there were no significant differences in forecasts across fluency conditions. Fluency may be discounted in a task which provides information that affects people's lives. This interpretation was bolstered by a second experiment whose participants were students in a statistics course. These students read the cognitive course's syllabus and forecasted better grades and less difficulty in the cognitive course when the font of the syllabus was more clear than unclear.

  6. Programming iOS 4 Fundamentals of iPhone, iPad, and iPod touch Development

    CERN Document Server

    Neuburg, Matt

    2011-01-01

    Get a solid grounding in all the fundamentals of Cocoa Touch, and avoid problems during iPhone and iPad app development. With Programming iOS 4, you'll dig into Cocoa and learn how to work effectively with Objective-C and Xcode. This book covers iOS 4 in a rigorous, orderly fashion-ideal whether you're approaching iOS for the first time or need a reference to bolster existing skills. Learn Objective-C language details and object-oriented programming conceptsUnderstand the anatomy of an Xcode project and all the stages of its lifecycleGrasp key Cocoa concepts such as relationships between clas

  7. Social media as social capital of LGB individuals in Hong Kong: its relations with group membership, stigma, and mental well-being.

    Science.gov (United States)

    Chong, Eddie S K; Zhang, Yin; Mak, Winnie W S; Pang, Ingrid H Y

    2015-03-01

    Social media are found to facilitate social information exchange among lesbian, gay, and bisexual (LGB) individuals who are subjected to social stigma. This study tested the protective role of LGB-tailored social media uses and gratifications in promoting LGB group membership, which we hypothesized to reduce LGB stigma and enhance mental health among LGB individuals in Hong Kong. Based on a sample of 233 Chinese LGB individuals in Hong Kong, structural equation modeling showed evidence for our hypotheses, χ(df=62)(2)= 88.20, GFI = 0.95, CFI = 0.98, NNFI = 0.98, SRMR = 0.07, RMSEA = 0.04. Community surveillance, identity expression, and emotional support on social media may promote mental health by instilling a sense of group membership and reducing stigma. Social media may build camaraderie and bolster resilience among LGB individuals that may otherwise be difficult in conservative regions.

  8. "To Bluff like a Man or Fold like a Girl?" - Gender Biased Deceptive Behavior in Online Poker.

    Directory of Open Access Journals (Sweden)

    Jussi Palomäki

    Full Text Available Evolutionary psychology suggests that men are more likely than women to deceive to bolster their status and influence. Also gender perception influences deceptive behavior, which is linked to pervasive gender stereotypes: women are typically viewed as weaker and more gullible than men. We assessed bluffing in an online experiment (N = 502, where participants made decisions to bluff or not in simulated poker tasks against opponents represented by avatars. Participants bluffed on average 6% more frequently at poker tables with female-only avatars than at tables with male-only or gender mixed avatars-a highly significant effect in games involving repeated decisions. Nonetheless, participants did not believe the avatar genders affected their decisions. Males bluffed 13% more frequently than females. Unlike most economic games employed exclusively in research contexts, online poker is played for money by tens of millions of people worldwide. Thus, gender effects in bluffing have significant monetary consequences for poker players.

  9. Clean Energy Manufacturing: U.S. Competitiveness and State Policy Strategies (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.

    2014-02-01

    The capital intensive nature of clean energy technologies suggests that manufacturing clean energy equipment has the potential to support state and local economic development efforts. However, manufacturing siting decisions tend to be complex and multi-variable decision processes that require in-depth knowledge of specific markets, the logistical requirements of a given technology, and insight into global clean tech trends. This presentation highlights the potential of manufacturing in supporting economic development opportunities while also providing examples of the financial considerations affecting manufacturing facility siting decisions for wind turbine blades and solar PV. The presentation also includes discussion of other more qualitative drivers of facility siting decisions as gleaned from NREL industry interviews and discusses strategies state and local policymakers may employee to bolster their chances of successfully attracting clean energy manufacturers to their localities.

  10. Applications of Optical Microcavity Resonators in Analytical Chemistry.

    Science.gov (United States)

    Wade, James H; Bailey, Ryan C

    2016-06-12

    Optical resonator sensors are an emerging class of analytical technologies that use recirculating light confined within a microcavity to sensitively measure the surrounding environment. Bolstered by advances in microfabrication, these devices can be configured for a wide variety of chemical or biomolecular sensing applications. We begin with a brief description of optical resonator sensor operation, followed by discussions regarding sensor design, including different geometries, choices of material systems, methods of sensor interrogation, and new approaches to sensor operation. Throughout, key developments are highlighted, including advancements in biosensing and other applications of optical sensors. We discuss the potential of alternative sensing mechanisms and hybrid sensing devices for more sensitive and rapid analyses. We conclude with our perspective on the future of optical microcavity sensors and their promise as versatile detection elements within analytical chemistry.

  11. Steepest descent ballistic deposition of complex shaped particles

    Science.gov (United States)

    Topic, Nikola; Pöschel, Thorsten

    2016-03-01

    We present an efficient event-driven algorithm for sequential ballistic deposition of complex-shaped rigid particles. Each of the particles is constructed from hard spheres (typically 5 … 1000) of variable radii. The sizes and relative positions of the spheres may mutually overlap and can be chosen such that the surface of the resulting particle appears relatively smooth. In the sequential deposition process, by performing steps of rolling and linear motion, the particles move along the steepest descent in a landscape formed by the boundaries and previously deposited particles. The computer time for the simulation of a deposition process depends on the total number of spheres but only weakly on the sizes and shapes of the particles. The proposed algorithm generalizes the Visscher-Bolsterli algorithm [1] which is frequently used for packing of spheres, to non-spherical particles. The proposed event-driven algorithm allows simulations of multi-million particle systems using desktop computers.

  12. October Surprises.

    Science.gov (United States)

    2016-10-01

    Ushered in with the rampage of Hurricane Matthew, later days brightened in this month that has often been harbinger of both good and bad news for Cuba and the world. Hurricane Matthew ripped through Eastern Cuba, devastating the historic town of Baracoa (Cuba's first capital, founded in 1511) and the village of Maisí, where the morning sun first rises over Cuban territory. Wind and flood leveled hundreds of homes, brought down the power grid and destroyed crops. Yet there was no loss of human life, unlike in neighboring Haiti and other countries in Matthew's path, and unlike in Cuba in 1963, when Hurricane Flora caused more than 1200 deaths. In Haiti, efforts of health workers-including hundreds of Haitian graduates from Cuba's Latin American Medical School and 600 Cuban health professionals already there-were bolstered by dozens of specially trained Cuban disaster medical personnel in the wake of the storm.

  13. Economic Conditions affect Support for Prime Minister parties in Scandinavia

    DEFF Research Database (Denmark)

    Larsen, Martin Vinæs

    2016-01-01

    Previous research has not been able to identify a relationship between objective economic indicators and support for governing parties in the Scandinavian countries. This is potentially problematic, as it suggests that political leaders are not held electorally accountable for the economic...... conditions they provide for their electorates. In this article, it is suggested that this null-finding is a result of the particularities of the Scandinavian electoral context, which makes it difficult to identify the effects of the economy on electoral support. To bolster this argument, the relationship...... correlates support for the prime minister's party with economic conditions, there is no relationship; however, if one specifies a statistical model, which takes the Scandinavian context into account, it is possible to identify a statistically significant effect of economic conditions on electoral support...

  14. A Content Analysis of the Image Repair Discourses of OSI Group in China’s Food-safety Scandal

    Institute of Scientific and Technical Information of China (English)

    Ya XIE; Xiaojun YAO

    2016-01-01

    Food safety is one of the top issues for Chinese consumers. In the summer of 2014,Shanghai-based Husi Food Co Ltd was mired in a food-safety scandal. OSI Group responded to this situation by releasing statements and holding China press conference. This study focused on OSI Group’s image repair strategies employed in the scandal in Chinese context. A content analysis revealed that OSI Group’s image repair relied primarily on six strategies: defeasibility( appalled by the event),bolstering( factory in Henan is state-of-art),minimization( it was an isolated event),corrective action( thorough internal investigation),and mortification( sincerely apologized),and attacking the accuser( launched OSI Food Safety Education Campaign). Basically,OSI Group’s mortification without compensation doomed its efforts to failure.Implications for implementing image repair strategies with the combination of crisis types are addressed.

  15. Transformation of a City

    Directory of Open Access Journals (Sweden)

    Trenessa L. Williams

    2016-10-01

    Full Text Available Gentrification changes the landscape and the cultural makeup of a city by increasing property values and changing consumption patterns. Since the late 1980s, gentrification has challenged the residential and small business community of Harlem, New York. Guided by the rent gap theory and the consumption-side theory, the purpose of this case study was to explore how small business leaders can compete with demographical changes brought by gentrification. A purposive sample of 20 Harlem small business owners operating during the city’s gentrification participated in interviews. Interview interpretations were triangulated with government documents and periodicals to bolster the trustworthiness of the final report. These findings may contribute to positive social change by informing the strategies employed by small business owners who are currently facing gentrification.

  16. Managing CSR Globally and Locally

    DEFF Research Database (Denmark)

    L. Brown, Dana; Knudsen, Jette Steen

    Corporate Responsibility (CR) is today an essential component of corporate global strategy. CR can bolster the institutional context for market expansion (Porter and Kramer 2006); fill institutional voids (Tarun, et.al. 2005); or facilitate market entry as a component of non-market strategy (Baron...... 2006). Yet, in fulfilling these functions, CR may need to be highly sensitive to local contexts. How can transnational firms organize CR so as to maximize efficiencies from globalization and to minimize the fragmentation of corporate organizational cultures? Bartlett and Ghoshal (1989) provide...... a framework for analyzing the way that corporations coordinate global and local functions. We build on this framework in a case study of Novo Nordisk and its approach to determining global and local CR policies and procedures with regard to its China and United States subsidiaries. Our findings suggest...

  17. Managing Corporate Responsibility Globally and Locally

    DEFF Research Database (Denmark)

    Brown, Dana; Knudsen, Jette Steen

    2012-01-01

    Corporate Responsibility (CR) is today an essential component of corporate global strategy. CR can bolster the institutional context for market expansion fill institutional voids or facilitate market entry as a component of non-market strategy. Yet, in fulfilling these functions, CR may need...... to be highly sensitive to local contexts. How can transnational firms organize CR so as to maximize efficiencies from globalization and to minimize the fragmentation of corporate organizational cultures? provide a framework for analyzing the way that corporations coordinate global and local functions. We build...... on this framework in a case study of Novo Nordisk and its approach to determining global and local CR policies and procedures with regard to its China and US subsidiaries. Our findings suggest that it is important for companies to define a common set of organizational norms. In addition, CR need to be sensitive...

  18. Expected taste intensity affects response to sweet drinks in primary taste cortex.

    Science.gov (United States)

    Woods, Andrew T; Lloyd, Donna M; Kuenzel, Johanna; Poliakoff, Ellen; Dijksterhuis, Garmt B; Thomas, Anna

    2011-06-11

    Expectations about a food can impact on its taste, but this may represent a perceptual change or a bias in response at the decision-making stage. We hypothesised that expectation of taste intensity should be underpinned by modulation of activity in primary taste cortex. Using functional magnetic resonance imaging, we found that expecting a very sweet drink, but receiving a less sweet drink, enhanced the reported sweetness and bolstered activity in taste cortex, relative to a less sweet drink without this expectation. The activation overlapped with primary taste cortex activation found in 11 recent taste studies. Our findings provide evidence that taste expectation modulates activity in an area consistently reported as primary taste cortex, implying that expectation effects do indeed impact on taste perception.

  19. Nursing Homes That Increased The Proportion Of Medicare Days Achieved Gains In Quality

    Science.gov (United States)

    Lepore, Michael; Leland, Natalie E.

    2017-01-01

    Nursing homes are increasingly serving short-stay rehabilitation residents under Medicare skilled nursing facility coverage, which is substantially more generous than Medicaid coverage for long-stay residents. In relation to increasing short-stay resident care, potential exists for beneficial or detrimental effects on long-stay resident outcomes. We employ panel multivariate regression analyses using facility fixed-effects models to determine how increasing the proportion of Medicare days in nursing homes relates to changes in quality outcomes for long-stay residents. We find increasing the proportion of Medicare days in a nursing home is significantly associated with improved quality outcomes for long-stay residents. Findings reinforce prior research indicating that quality outcomes tend to be superior in nursing homes with greater financial resources. This study bolsters arguments for financial investments in nursing homes, including increases in Medicaid payment rates, to support better care. PMID:26643633

  20. An Account of ... William Cullen: John Thomson and the Making of a Medical Biography.

    Science.gov (United States)

    Shuttleton, David E

    2014-01-01

    John Thomson's An Account of the Life, Lectures and Writings of William Cullen (1832; 1859) remains a primary source for the career of the most influential academic physician in eighteenth-century Scotland and is also a significant work of medical history. But this multi-authored text, begun around 1810 by the academic surgeon, John Thomson, but only completed in 1859 by Dr David Craigie, has its own complex history. This chapter addresses what this history can reveal about the development of medical biography as a literary genre. It argues that the Account is a hybrid work shaped by a complex array of practical, domestic, intellectual, and professional pressures, as Thomson, in seeking to bolster his own career, was caught between the demands of Cullen's children for a traditional "Life" and his own more theoretical and socio-cultural interests.

  1. Analysis of Batik Value Chain in Ethnic Minority Areas--A Case Study of Danzhai County in Guizhou Province

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Based on value chain analysis method,we surveyed and interviewed interest groups of batik industry in Danzhai County.From raw material production,product processing,marketing,organization and management,we discussed the supply chain of batik products in ethnic minority areas,and analyzed favorable factors of batik industry development and obstacles to interest groups developing batik industry.Finally,we put forward corresponding policy suggestions,including strengthening farmers’ ability in batik production section,enhancing capability construction of batik cooperatives and associations,increasing cultural value added of batik products,bolster policy and financial support of government departments,and promoting establishment of cooperative mechanism for handicrafts.

  2. FIPSER: Performance Study of a Readout Concept With Few Digitization Levels for Fast Signals

    CERN Document Server

    Limyansky, Brent; Cressler, John D; Otte, Adam Nepomuk; Taboada, Ignacio; Ulusoy, Cagri

    2016-01-01

    We discuss the performance of a readout system, Fixed Pulse Shape Efficient Readout (FIPSER), to digitize signals from detectors with a fixed pulse shape. In this study we are mainly interested in the readout of fast photon detectors like photomultipliers or Silicon photomultipliers. But the concept can be equally applied to the digitization of other detector signals. FIPSER is based on the flash analog to digital converter (FADC) concept, but has the potential to lower costs and power consumption by using an order of magnitude fewer discrete voltage levels. Performance is bolstered by combining the discretized signal with the knowledge of the underlying pulse shape. Simulated FIPSER data was reconstructed with two independent methods. One using a maximum likelihood method and the other using a modified chisquared test. Both methods show that utilizing 12 discrete voltage levels with a sampling rate of 4 samples per full width half maximum (FWHM) of the pulse achieves an amplitude resolution that is better th...

  3. Invited commentary: Assessment of air pollution and suicide risk.

    Science.gov (United States)

    Guo, Yuming; Barnett, Adrian G

    2015-03-01

    Suicide is a serious public health issue worldwide, with multiple risk factors, such as severe mental illness, alcohol abuse, a painful loss, exposure to violence, or social isolation. Environmental factors, particularly chemical and meteorological variables, have been examined as risk factors for suicide, but less evidence is available on whether air pollution is related to suicide. In this issue of the Journal, Bakian et al. ( publish findings from a study that found a short-term increased risk of suicide associated with increased air pollution. This study bolsters a small body of research linking air pollution exposure to suicide risk. If the association between air pollution and suicide is confirmed, it would broaden the scope of the already large disease burden associated with air pollution.

  4. Using interorganizational partnerships to strengthen public health laboratory systems.

    Science.gov (United States)

    Hsieh, Kristina; Kimsey, Paul; Buehring, Gertrude

    2013-01-01

    Due to the current economic environment, many local and state health departments are faced with budget reductions. Health department administrators and public health laboratory (PHL) directors need to assess strategies to ensure that their PHLs can provide the same level of service with decreased funds. Exploratory case studies of interorganizational partnerships among local PHLs in California were conducted to determine the impact on local PHL testing services and capacity. Our findings suggest that interorganizational forms of cooperation among local PHLs can help bolster laboratory capacity by capturing economies of scale, leveraging scarce resources, and ensuring access to affordable, timely, and quality laboratory testing services. Interorganizational partnerships will help local and state public health departments continue to maintain a strong and robust laboratory system that supports their role in communicable disease surveillance.

  5. Analysis of Various Computer System Monitoring and LCD Projector through the Network TCP/IP

    Directory of Open Access Journals (Sweden)

    Santoso Budijono

    2015-12-01

    Full Text Available Many electronic devices have a network connection facility. Projectors today have network facilities to bolster its customer satisfaction in everyday use. By using a device that can be controlled, the expected availability and reliability of the presentation system (computer and projector can be maintained to keep its condition ready to use for presentation. Nevertheless, there is still a projector device that has no network facilities so that the necessary additional equipment with expensive price. Besides, control equipment in large quantities has problems in timing and the number of technicians in performing controls. This study began with study of literature, from searching for the projectors that has LAN and software to control and finding a number of computer control softwares where the focus is easy to use and affordable. Result of this research is creating a system which contains suggestions of procurement of computer hardware, hardware and software projectors each of which can be controlled centrally from a distance.

  6. In the balance

    DEFF Research Database (Denmark)

    Kluth, Michael Friederich; Pilegaard, Jess

    The present paper seeks to make sense of recent EU naval capability changes by applying neo-realist theory on the EU as an international actor in the global balance of power. The paper compares three different strands of Neo-realist theory by deducting key predictions about the expected defense...... posture of the Union and the expected changes in naval capabilities. The predictions are subsequently held up against recent data on naval military build-up in the EU. The paper argues that the observed patterns are best explained not as bandwagoning with the United States, but as a long-term balancing...... strategy aimed at bolstering the autonomy and international influence of the Union, vis-à-vis other major powers, including the United States....

  7. A life-cycle approach to food and nutrition security in India.

    Science.gov (United States)

    Rai, Rajesh Kumar; Kumar, Sandhya; Sekher, Madhushree; Pritchard, Bill; Rammohan, Anu

    2015-04-01

    India's poor performance on critical food and nutrition security indicators despite substantial economic prosperity has been widely documented. These failings not only hamper national progress, but also contribute significantly to the global undernourished population, particularly children. While the recently passed National Food Security Act 2013 adopts a life-cycle approach to expand coverage of subsidized food grains to the most vulnerable households and address food security, there remains much to be desired in the legislation. Access to adequate food for 1.24 billion people is a multifaceted problem requiring an interconnected set of policy measures to tackle the various factors affecting food and nutrition security in India. In the present opinion paper, we discuss a fivefold strategy that incorporates a life-cycle approach, spanning reproductive health, bolstering citizen participation in existing national programmes, empowering women, advancing agriculture and better monitoring the Public Distribution System in order to fill the gaps in both access and adequacy of food and nutrition.

  8. The people's role in U.S. national health security: past, present, and future.

    Science.gov (United States)

    Schoch-Spana, Monica

    2012-03-01

    Over the past decade, assumptions have been made and unmade about what officials can expect of average people confronting a bioterrorist attack or other major health incident. The reframing of the public in national discourse and doctrine from a panic-stricken mob to a band of hearty survivors is a positive development and more realistic in terms of the empirical record. So, too, is the realization that citizen contributions to national health security encompass not only individual preparedness and volunteerism but also mutual aid and collective deliberation of the tough choices posed by health disasters. In projecting what needs to occur over the next 10 years in biosecurity, 2 priority challenges emerge: retaining the lesson that a public prone to panic, social disorder, and civil unrest is a myth, and building an infrastructure to bolster the public's full contributions to health emergency management.

  9. Panel Resource Management (PRM) Implementation and Effects within Safety Review Panel Settings and Dynamics

    Science.gov (United States)

    Taylor, Robert W.; Nash, Sally K.

    2007-01-01

    While technical training and advanced degree's assure proficiency at specific tasks within engineering disciplines, they fail to address the potential for communication breakdown and decision making errors familiar to multicultural environments where language barriers, intimidating personalities and interdisciplinary misconceptions exist. In an effort to minimize these pitfalls to effective panel review, NASA's lead safety engineers to the ISS Safety Review Panel (SRP), and Payload Safety Review Panel (PSRP) initiated training with their engineers, in conjunction with the panel chairs, and began a Panel Resource Management (PRM) program. The intent of this program focuses on the ability to reduce the barriers inhibiting effective participation from all panel attendees by bolstering participants confidence levels through increased communication skills, situational awareness, debriefing, and a better technical understanding of requirements and systems.

  10. Linking population, fertility, and family planning with adaptation to climate change: perspectives from Ethiopia.

    Science.gov (United States)

    Rovin, Kimberly; Hardee, Karen; Kidanu, Aklilu

    2013-09-01

    Global climate change is felt disproportionately in the world's most economically disadvantaged countries. As adaption to an evolving climate becomes increasingly salient on national and global scales, it is important to assess how people at the local-level are already coping with changes. Understanding local responses to climate change is essential for helping countries to construct strategies to bolster resilience to current and future effects. This qualitative research investigated responses to climate change in Ethiopia; specifically, how communities react to and cope with climate variation, which groups are most vulnerable, and the role of family planning in increasing resilience. Participants were highly aware of changing climate effects, impacts of rapid population growth, and the need for increased access to voluntary family planning. Identification of family planning as an important adaptation strategy supports the inclusion of rights-based voluntary family planning and reproductive health into local and national climate change adaptation plans.

  11. A Change for the Better

    DEFF Research Database (Denmark)

    Rozendal, Arjan; Lim, Eric T. K.; Tan, Chee-Wee

    2015-01-01

    Investments in information technology will only yield dividends whenever technological spending complements corporate objectives, a phenomenon termed as business-IT alignment within extant literature. Synthesizing extant literature on business-IT alignment and organizational change, this paper...... argues for effective change management as a means for organizations to realize business-IT alignment. Findings from a grounded theory study revealed that having clear assessment criteria, promoting information exchange, getting managers to act as role models, expanding the involvement and participation...... of employees in decision making as well as drawing on positive collaborative experiences in the past bolster the success of change initiatives for realizing business-IT alignment. Conversely, pursuing partisan interest at the expense of the organization, speaking different professional languages, displaying...

  12. Results and Status of the T2K and NOvA long-baseline neutrino experiments

    Science.gov (United States)

    Muether, Mathew

    2016-03-01

    The discovery of neutrino oscillations and the resulting implication that neutrinos have mass, recently awarded the Nobel Prize in Physics, has bolstered a world-wide effort to exploit this effect as a handle on the properties of neutrinos. In the decades since the initial discovery of neutrino oscillations, great strides have been made in understanding the nature of these elusive particles, yet important and fundamental questions remain open, such as: How are the neutrino masses ordered? And Do neutrinos and antineutrinos oscillate differently? The current generation of accelerator based long-baseline neutrino oscillation experiments, T2K in Japan and NOvA in the United States, are actively pursuing the answers to these questions. In this talk, I will review the recent results and current status of the T2K and NOvA long-baseline neutrino experiments.

  13. Psychical research and the origins of American psychology

    Science.gov (United States)

    Sommer, Andreas

    2012-01-01

    Largely unacknowledged by historians of the human sciences, late-19th-century psychical researchers were actively involved in the making of fledgling academic psychology. Moreover, with few exceptions historians have failed to discuss the wider implications of the fact that the founder of academic psychology in America, William James, considered himself a psychical researcher and sought to integrate the scientific study of mediumship, telepathy and other controversial topics into the nascent discipline. Analysing the celebrated exposure of the medium Eusapia Palladino by German-born Harvard psychologist Hugo Münsterberg as a representative example, this article discusses strategies employed by psychologists in the United States to expel psychical research from the agenda of scientific psychology. It is argued that the traditional historiography of psychical research, dominated by accounts deeply averse to its very subject matter, has been part of an ongoing form of ‘boundary-work’ to bolster the scientific status of psychology. PMID:23355763

  14. How big are the smallest drops of quark-gluon plasma?

    CERN Document Server

    Chesler, Paul M

    2016-01-01

    Using holographic duality, we present results for both head-on and off-center collisions of Gaussian shock waves in strongly coupled $\\mathcal N = 4$ supersymmetric Yang-Mills theory. The shock waves superficially resemble Lorentz contracted colliding protons. The collisions results in the formation of a plasma whose evolution is well described by viscous hydrodynamics. The size of the produced droplet is $R \\sim 1/T_{\\rm eff}$ where $T_{\\rm eff}$ is the effective temperature, which is the characteristic microscopic scale in strongly coupled plasma. These results demonstrate the applicability of hydrodynamics to microscopically small systems and bolster the notion that hydrodynamics can be applied to heavy-light ion collisions as well as some proton-proton collisions.

  15. Innovation adoption as facilitated by a change-oriented workplace.

    Science.gov (United States)

    Becan, Jennifer E; Knight, Danica K; Flynn, Patrick M

    2012-03-01

    One of the unique contributions of this study is a glimpse into the process by which counselors decide to try new innovations in their clinical work. Data were collected from 421 counseling staff from 71 outpatient treatment programs in 4 U.S. regions. Using hierarchical linear modeling, results reveal that the propensity to adopt workshop-based interventions is facilitated by two important mechanisms: (a) an innovative organization with creative leadership and (b) change-oriented staff attributes (i.e., seeking professional growth, efficacy, adaptability, and influence on others). Innovative leaders and a climate receptive to change also bolster the development of these change-oriented attributes. One implication of these findings is the cascading effect of leaders' support of innovative thinking and action resulting in employees strengthening their own adaptive skills and carrying this innovative thinking into individual adoption.

  16. Changing public perceptions of genetically modified foods

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Bech-Larsen, Tino; Grunert, Klaus G.

    2001-01-01

    . In esperiment 1, attitude change experiments were conducted with consumers from Denmark, Germany, Italy and the UK (N=1650). Different information strategies were tested against a control group for their ability to change consumers' attitudes and their influence on product choice. Results indicate...... that no attitude change occured. Instead, all strategies seemed to bolster pre-existing attitudes, thereby significantly decreasing consumers' preferences for GM products. The effect did not occur when consumers only saw a labeled product example. In experiment 2, we tested the effects of direct experience......Previous research concerning public perception of GM foods indicates that European consumers hold firm negative attitudes to GM foods. These attitudes, however, are not based on risk-benefit evaluations of particular products. Rather, they seem to be a function of general sociopolitical attitudes...

  17. Science and Technology Review January/February 2011

    Energy Technology Data Exchange (ETDEWEB)

    Blobaum, K J

    2010-11-22

    This month's issue has the following articles: (1) World's Most Intense X-Ray Laser Focuses on Livermore Science - Commentary by William H. Goldstein; (2) Groundbreaking Science with the World's Brightest X Rays - Experiments with x rays of unparalleled brightness and extremely short duration aim to reveal new information about atoms and molecules in motion; (3) From Data to Discovery - Ongoing control system enhancements at the National Ignition Facility bolster the understanding of experimental data and keep the system performing at its peak; (4) The Sun in All Its Splendor - Onboard the Solar Dynamics Observatory, Livermore-developed multilayer mirrors are enabling unprecedented full-disk, high-resolution images of the Sun; and (5) Drilling Deep into Plant Veins - A novel combination of imaging techniques is being used to understand the three-dimensional architecture of plant cell walls.

  18. The pulsar planet production process

    Science.gov (United States)

    Phinney, E. S.; Hansen, B. M. S.

    1993-01-01

    Most plausible scenarios for the formation of planets around pulsars end with a disk of gas around the pulsar. The supplicant author then points to the solar system to bolster faith in the miraculous transfiguration of gas into planets. We here investigate this process of transfiguration. We derive analytic sequences of quasi-static disks which give good approximations to exact solutions of the disk diffusion equation with realistic opacity tables. These allow quick and efficient surveys of parameter space. We discuss the outward transfer of mass in accretion disks and the resulting timescale constraints, the effects of illumination by the central source on the disk and dust within it, and the effects of the widely different elemental compositions of the disks in the various scenarios, and their extensions to globular clusters. We point out where significant uncertainties exist in the appropriate grain opacities, and in the effect of illumination and winds from the neutron star.

  19. A pilot feasibility study of a peer-led mindfulness program for medical students

    Science.gov (United States)

    Danilewitz, Marlon; Bradwejn, Jacques; Koszycki, Diana

    2016-01-01

    Background Mindfulness meditation has gained momentum in medical circles for bolstering wellbeing and other facets of professionalism. This study evaluated the feasibility and benefits of a peer-led mindfulness meditation program (MMP) on medical student wellness and professionalism. Method Pre-clerkship students were recruited and randomized to the 8-week MMP or wait-list. Feasibility outcomes included ease of recruitment, program attendance and homework compliance. Other outcomes included self-reported psychological distress, empathy, self-compassion, mindfulness, altruism and program satisfaction. Results The MMP decreased levels of stress and enhanced mindfulness, self-compassion and altruism from baseline to post-study. Changes were not significant for the wait-list condition. Although satisfaction with the MMP was high compliance was suboptimal. Conclusions A peer-led MMP is feasible and may be a promising approach to enhance medical student wellbeing. Further research is needed to explore strategies to improve program compliance in this student population. PMID:27103950

  20. Organized Abuse in Adulthood: Survivor and Professional Perspectives.

    Science.gov (United States)

    Salter, Michael

    2017-02-23

    This paper reports on the preliminary findings of a qualitative study of Australian women disclosing organized abuse in adulthood and the mental health professionals who treat them. Drawing on interviews with survivors and mental health professionals, the paper analyses the fraught relationship between mental health and physical safety for adults subject to organized abuse. The therapeutic progress of adult organized abuse victims can be disrupted by ongoing threats, stalking, and group violence, which in turn reinforces the dissociative responses and pathological attachments that render them vulnerable to revictimization. The paper argues that breaking this cycle requires intervention from multiple agencies, and describes the responses of police, medical services, and child protection services to adult organized abuse from the perspective of survivors and mental health practitioners. Highlighting systemic failures but also opportunities, the paper calls for a coordinated response to organized abuse in adulthood, including inter-agency partnerships to support safety and bolster the efficacy of therapeutic interventions.

  1. Suppression of tritium retention in remote areas of ITER by nonperturbative reactive gas injection.

    Science.gov (United States)

    Tabarés, F L; Ferreira, J A; Ramos, A; van Rooij, G; Westerhout, J; Al, R; Rapp, J; Drenik, A; Mozetic, M

    2010-10-22

    A technique based on reactive gas injection in the afterglow region of the divertor plasma is proposed for the suppression of tritium-carbon codeposits in remote areas of ITER when operated with carbon-based divertor targets. Experiments in a divertor simulator plasma device indicate that a 4  nm/min deposition can be suppressed by addition of 1  Pa·m³ s⁻¹ ammonia flow at 10 cm from the plasma. These results bolster the concept of nonperturbative scavenger injection for tritium inventory control in carbon-based fusion plasma devices, thus paving the way for ITER operation in the active phase under a carbon-dominated, plasma facing component background.

  2. Craig and Kalam Cosmological Argument

    Directory of Open Access Journals (Sweden)

    Gholamhosein Tavacoly

    2011-09-01

    Full Text Available   Among different arguments for the existence of God the Kalam cosmological argument is a very famous one which is elaborated by Professor William lane Craig. Craig claims that the universe began to exist , then he continues to say: everything that begins to exist has a cause and therefore the universe has a cause. But how do we know that the universe began to exist? This premise forms the most important part of Craig’s contention, and he bolsters it by four arguments, the first two are driven from philosophy and the other two, which he prefers to name them “confirmations from sciences” are driven from sciences the first one evokes to big bang theory and the seconds to the second principle of thermodynamic which are respectively adopted from cosmology and physics.   In this essay we are going to survey Craig’s arguments and estimate their value and weight.

  3. Craig and Kalam Cosmological Argument

    Directory of Open Access Journals (Sweden)

    Tavacoli, Gh

    2011-01-01

    Full Text Available Among different arguments for the existence of God the Kalam cosmological argument is a very famous one which is elaborated by Professor William lane Craig. Craig claims that the universe began to exist, then he continues to say: everything that begins to exist has a cause and therefore the universe has a cause. But how do we know that the universe began to exist? This premise forms the most important part of Craig’s contention, and he bolsters it by four arguments, the first two are driven from philosophy and the other two, which he prefers to name them “confirmations from sciences” are driven from sciences; the first one evokes to big bang theory and the seconds to the second principle of thermodynamic which are respectively adopted from cosmology and physics.In this essay we are going to survey Craig’s arguments and estimate their value and weight.

  4. Determinants of Scale Efficiency in the Brazilian Third-Party Logistics Industry from 2001 to 2009

    Directory of Open Access Journals (Sweden)

    Peter F. Wanke

    2012-01-01

    Full Text Available This article investigates the Brazilian third-party logistics (3PL sector which, increasingly competitive, offers clients a wide variety of services/information technologies in the quest to bolster efficiency. The main research objective is to determine which variables significantly impact 3PLs scale efficiency by applying two-stage DEA (Data Envelopment Analysis. Based on an unbalanced panel model, data from the annual study published by Revista Tecnologística (years 2001–2009 were analyzed. Results corroborate evidence in the literature that coordination mechanisms in the supply chain, supported by the availability of real time information and inventory synchronization, favor a more rational allocation of resources (inputs to client demands (outputs.

  5. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, Jo A.; Jochems, Caroline [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Gulley, James L. [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Schlom, Jeffrey, E-mail: js141c@nih.gov; Tsang, Kwong Y. [Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States)

    2012-12-11

    Active immunotherapy is dependent on the ability of the immune system to recognize and respond to tumors. Despite overwhelming evidence to support a cell-mediated immune response to prostate cancer, it is insufficient to eradicate the disease. This is likely due to a high level of suppression at the tumor site from a variety of sources, including immunosuppressive cells. Immune cells entering the tumor microenvironment may be inhibited directly by the tumor, stromal cells or other immune cells that have been induced to adopt a suppressive phenotype. The resurgence of interest in immunotherapy following the approval of sipuleucel-T and ipilimumab by the Food and Drug Administration has brought about new strategies for overcoming tumor-mediated suppression and bolstering anti-tumor responses. Improved understanding of the immune response to prostate cancer can lead to new combination therapies, such as the use of vaccine with small molecule and checkpoint inhibitors or other immunotherapies.

  6. [Health education in schools in Argentina: an art contest as a motivating activity].

    Science.gov (United States)

    Darnaud, Raquel; Dato, María Isabel

    2009-02-01

    The purpose of this study was to plan health education efforts that integrate the health and education sectors. From March to November 2004, an art contest was held for 7th-9th grade students in 109 schools in 11 of Argentina's provinces. The contest allowed improvements in knowledge to be measured and adjustments to be made to the curriculum. The students created works of art featuring tuberculosis. To evaluate knowledge acquired, two provinces were chosen at random. Student knowledge had increased from 67.2% to 96.4%. The administrators and teachers testified to the usefulness of the materials developed. These results show that when the efforts of health and education sectors are coordinated and the appropriate materials are leveraged, the efforts of educators can be substantially bolstered.

  7. Zr and Sn substituted (Na0.5Bi0.5)TiO3 -based solid solutions

    Science.gov (United States)

    Ishchuk, V. M.; Gusakova, L. G.; Kisel, N. G.; Kuzenko, D. V.; Spiridonov, N. A.; Sobolev, V. L.

    2016-02-01

    The paper attempts to investigate the phase formation of a Zr- and Sn-substituted [(Na0.5Bi0.5)0.80Ba0.20](Ti1-yBy)O3 system during its solid state synthesis. The synthesis was found to be a multi-step process associated with the formation of a number of intermediate phases which however depended on the compositions and sintering temperatures. Single phase solid solutions were obtained when the sintering temperature was increased to 1000 °C-1100 °C. Increase in the concentration of substituting ions, on the one hand, tends to linearly increase the crystal cell size whereas the tolerance factor, on the other hand, gets reduced bolstering the stability of anti-ferroelectric phase as compared to that of ferroelectric phase’.

  8. Great expectations: autism spectrum disorder and induced pluripotent stem cell technologies.

    Science.gov (United States)

    Liu, Emily Yang; Scott, Christopher Thomas

    2014-04-01

    New applications of iPSC technology to research on complex idiopathic conditions raise several important ethical and social considerations for potential research participants and their families. In this short review, we examine these issues through the lens of emerging research on autism spectrum disorder (ASD). We begin by describing the current state of iPSC technology in research on ASD. Then we discuss how the social history of and current controversies in autism research combined with the emergence of autism-specific iPSC biobanks indicate an urgent need for researchers to clearly communicate the limitations and possibilities of iPSC research to ensure research participants have the ability to provide fully informed, voluntary consent. We conclude by offering recommendations to bolster informed consent for research involving iPSC biobanks, both in the specific context of ASD and more broadly.

  9. Considering an affect regulation framework for examining the association between body dissatisfaction and positive body image in Black older adolescent females: does body mass index matter?

    Science.gov (United States)

    Webb, Jennifer B; Butler-Ajibade, Phoebe; Robinson, Seronda A

    2014-09-01

    The present study provided an initial evaluation of an affect regulation model describing the association between body dissatisfaction and two contemporary measures of positive body image among 247 Black college-bound older adolescent females. We further tested whether possessing a higher body mass index (BMI) would strengthen these associations. Self-reported height and weight were used to calculate BMI. Respondents also completed a culturally-sensitive figure rating scale along with assessments of body appreciation and body image flexibility. Results indicated a robust positive association between the two measures of positive body image; BMI was the strongest predictor of both body appreciation and body image flexibility with body size discrepancy (current minus ideal) contributing incremental variance to both models tested. Implications for improving our understanding of the association between positive and negative body image and bolstering positive body image to promote health-protective behaviors among Black young women at this developmental juncture are discussed.

  10. "Abomination"--life as a Bible belt gay.

    Science.gov (United States)

    Barton, Bernadette

    2010-01-01

    Drawing on observation, autoethnography, and audio-taped interviews, this article explores the religious backgrounds and experiences of Bible Belt gays. In the Bible Belt, Christianity is not confined to Sunday worship. Christian crosses, messages, paraphernalia, music, news, and attitudes permeate everyday settings. Consequently, Christian fundamentalist dogma about homosexuality-that homosexuals are bad, diseased, perverse, sinful, other, and inferior-is cumulatively bolstered within a variety of other social institutions and environments in the Bible Belt. Of the 46 lesbians and gay men interviewed for this study (age 18-74 years), most describe living through spirit-crushing experiences of isolation, abuse, and self-loathing. This article argues that the geographic region of the Bible Belt intersects with religious-based homophobia. Informants explained that negative social attitudes about homosexuality caused a range of harmful consequences in their lives including the fear of going to hell, depression, low self-esteem, and feelings of worthlessness.

  11. Historical time in the age of big data: Cultural psychology, historical change, and the Google Books Ngram Viewer.

    Science.gov (United States)

    Pettit, Michael

    2016-05-01

    Launched in 2010, the Google Books Ngram Viewer offers a novel means of tracing cultural change over time. This digital tool offers exciting possibilities for cultural psychology by rendering questions about variation across historical time more quantitative. Psychologists have begun to use the viewer to bolster theories about a historical shift in the United States from a more collectivist to individualist form of selfhood and society. I raise 4 methodological cautions about the Ngram Viewer's use among psychologists: (a) the extent to which print culture can be taken to represent culture as a whole, (b) the difference between viewing the past in terms of trends versus events, (c) assumptions about the stability of a word's meaning over time, and (d) inconsistencies in the scales and ranges used to measure change over time. The aim is to foster discussion about the standards of evidence needed for incorporating historical big data into empirical research.

  12. Shifting liberal and conservative attitudes using moral foundations theory.

    Science.gov (United States)

    Day, Martin V; Fiske, Susan T; Downing, Emily L; Trail, Thomas E

    2014-12-01

    People's social and political opinions are grounded in their moral concerns about right and wrong. We examine whether five moral foundations--harm, fairness, ingroup, authority, and purity--can influence political attitudes of liberals and conservatives across a variety of issues. Framing issues using moral foundations may change political attitudes in at least two possible ways: (a) Entrenching: Relevant moral foundations will strengthen existing political attitudes when framing pro-attitudinal issues (e.g., conservatives exposed to a free-market economic stance) and (b) Persuasion: Mere presence of relevant moral foundations may also alter political attitudes in counter-attitudinal directions (e.g., conservatives exposed to an economic regulation stance). Studies 1 and 2 support the entrenching hypothesis. Relevant moral foundation-based frames bolstered political attitudes for conservatives (Study 1) and liberals (Study 2). Only Study 2 partially supports the persuasion hypothesis. Conservative-relevant moral frames of liberal issues increased conservatives' liberal attitudes.

  13. The Interaction of Language-Specific and Universal Factors During the Acquisition of Morphophonemic Alternations With Exceptions.

    Science.gov (United States)

    Baer-Henney, Dinah; Kügler, Frank; van de Vijver, Ruben

    2015-09-01

    Using the artificial language paradigm, we studied the acquisition of morphophonemic alternations with exceptions by 160 German adult learners. We tested the acquisition of two types of alternations in two regularity conditions while additionally varying length of training. In the first alternation, a vowel harmony, backness of the stem vowel determines backness of the suffix. This process is grounded in substance (phonetic motivation), and this universal phonetic factor bolsters learning a generalization. In the second alternation, tenseness of the stem vowel determines backness of the suffix vowel. This process is not based in substance, but it reflects a phonotactic property of German and our participants benefit from this language-specific factor. We found that learners use both cues, while substantive bias surfaces mainly in the most unstable situation. We show that language-specific and universal factors interact in learning.

  14. Immunotherapy: Shifting the Balance of Cell-Mediated Immunity and Suppression in Human Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Jeffrey Schlom

    2012-12-01

    Full Text Available Active immunotherapy is dependent on the ability of the immune system to recognize and respond to tumors. Despite overwhelming evidence to support a cell-mediated immune response to prostate cancer, it is insufficient to eradicate the disease. This is likely due to a high level of suppression at the tumor site from a variety of sources, including immunosuppressive cells. Immune cells entering the tumor microenvironment may be inhibited directly by the tumor, stromal cells or other immune cells that have been induced to adopt a suppressive phenotype. The resurgence of interest in immunotherapy following the approval of sipuleucel-T and ipilimumab by the Food and Drug Administration has brought about new strategies for overcoming tumor-mediated suppression and bolstering anti-tumor responses. Improved understanding of the immune response to prostate cancer can lead to new combination therapies, such as the use of vaccine with small molecule and checkpoint inhibitors or other immunotherapies.

  15. Curtis's cephaloscope: deafness and the making of surgical authority in London, 1816-1845.

    Science.gov (United States)

    Virdi-Dhesi, Jaipreet

    2013-01-01

    Aural surgery is a branch of nineteenth-century medicine and surgery providing specialized treatment for ear diseases. During the 1830s, faced with a "popular prejudice" against the curability of deafness as well as intraprofessional rivalries and continuous accusations of quackery, aurists found their surgical authority questioned and their field's value threatened. In an attempt to bolster aural surgery's reputation, in 1841, the aurist John Harrison Curtis (1778-1856) introduced his new diagnostic instrument, the cephaloscope, which could not only improve diagnosis but also provide approaches for regulating aural knowledge, thus strengthening aural surgery's authority. This article examines the motives underlying Curtis's introduction of the cephaloscope and the meanings it held for the occupational group at large.

  16. How to shape positive relationships in medical practices and hospitals.

    Science.gov (United States)

    Sotile, W M; Sotile, M O

    1999-01-01

    Managing workplace conflict is one of the most important, stressful, and time-consuming tasks faced by today's medical leaders. Poorly managed workplace conflict can alienate patients, demoralize staff, increase turnover, damage relationships with valued referral sources and third party carriers concerned about patient satisfaction, and lead medical practices to costly "corporate divorces." Physician executives cannot solve the problems caused by disruptive doctors simply by bolstering their own conflict management skills or by policing offenders. The larger contexts within which inappropriate workplace behavior occurs must also be assessed and addressed. The true leadership challenge is to intervene in ways that help to foster a "culture" of appropriate interpersonal dynamics throughout your organization. This requires learning to think and to intervene systematically.

  17. Bilingualism increases neural response consistency and attentional control: evidence for sensory and cognitive coupling.

    Science.gov (United States)

    Krizman, Jennifer; Skoe, Erika; Marian, Viorica; Kraus, Nina

    2014-01-01

    Auditory processing is presumed to be influenced by cognitive processes - including attentional control - in a top-down manner. In bilinguals, activation of both languages during daily communication hones inhibitory skills, which subsequently bolster attentional control. We hypothesize that the heightened attentional demands of bilingual communication strengthens connections between cognitive (i.e., attentional control) and auditory processing, leading to greater across-trial consistency in the auditory evoked response (i.e., neural consistency) in bilinguals. To assess this, we collected passively-elicited auditory evoked responses to the syllable [da] in adolescent Spanish-English bilinguals and English monolinguals and separately obtained measures of attentional control and language ability. Bilinguals demonstrated enhanced attentional control and more consistent brainstem and cortical responses. In bilinguals, but not monolinguals, brainstem consistency tracked with language proficiency and attentional control. We interpret these enhancements in neural consistency as the outcome of strengthened attentional control that emerged from experience communicating in two languages.

  18. Stakeholders in Action

    DEFF Research Database (Denmark)

    of stakeholders and stakeholder roles, which may pave the way for dedicated management and communication strategies to enhance and bolster relationships. This volume follows in the footsteps of the many researchers who have studied and explored the field; however, as opposed to much current literature, which...... often takes a primarily theoretical approach to the study of stakeholders and stakeholder management, the chapters in this book are first and foremost focused on the practical aspects of the field. Thus, through seven separate case studies, the book discusses how stakeholders are constructed implicitly...... and explicitly in corporate and institutional texts, investigating the possible consequences of these constructions for the communication and engagement between stakeholders and organisations....

  19. Phased Retrofits in Existing Homes in Florida Phase II: Shallow Plus Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, K. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Parker, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Martin, E. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Chasar, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Amos, B. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States)

    2016-12-01

    Originally published in February 2016, this revision contains an added section called 'Evaluation of Complete Central System Replacement with Inverter-Driven Heat Pump,' which presents the designs and energy savings evaluations of two different schemes wherein inverter-driven systems replaced a home's existing central system. Analyses for three additional retrofit measures were bolstered by longer-term data; these are described in the sections on supplemental mini-split heat pumps (MSHPs), smart thermostats, and heat pump clothes dryers. The sections on supplemental MSHPs and smart thermostats were also enhanced with larger sample sizes and projections of weather-normalized annual energy savings. Finally, peak system hour energy demand-reduction predictions are provided for all retrofit measures where meaningful impacts could be drawn.

  20. Determinants of Job Satisfaction and Turnover Intent in Home Health Workers: The Role of Job Demands and Resources.

    Science.gov (United States)

    Jang, Yuri; Lee, Ahyoung A; Zadrozny, Michelle; Bae, Sung-Heui; Kim, Miyong T; Marti, Nathan C

    2017-01-01

    Based on the job demands-resources (JD-R) model, this study explored the impact of job demands (physical injury and racial/ethnic discrimination) and resources (self-confidence in job performance and recognition by supervisor/organization/society) on home health workers' employee outcomes (job satisfaction and turnover intent). Using data from the National Home Health Aide Survey (N = 3,354), multivariate models of job satisfaction and turnover intent were explored. In both models, the negative impact of demands (physical injury and racial/ethnic discrimination) and the positive impact of resources (self-confidence in job performance and recognition by supervisor and organization) were observed. The overall findings suggest that physical injury and discrimination should be prioritized in prevention and intervention efforts to improve home health workers' safety and well-being. Attention also needs to be paid to ways to bolster work-related efficacy and to promote an organizational culture of appreciation and respect.

  1. The Individuals With Disabilities Education Act (IDEA) for Children With Special Educational Needs.

    Science.gov (United States)

    Lipkin, Paul H; Okamoto, Jeffrey

    2015-12-01

    The pediatric health care provider has a critical role in supporting the health and well-being of children and adolescents in all settings, including early intervention (EI), preschool, and school environments. It is estimated that 15% of children in the United States have a disability. The Individuals with Disabilities Education Act entitles every affected child in the United States from infancy to young adulthood to a free appropriate public education through EI and special education services. These services bolster development and learning of children with various disabilities. This clinical report provides the pediatric health care provider with a summary of key components of the most recent version of this law. Guidance is also provided to ensure that every child in need receives the EI and special education services to which he or she is entitled.

  2. Full-thickness skin grafting in nasal reconstruction.

    Science.gov (United States)

    Weathers, William M; Bhadkamkar, Mohin; Wolfswinkel, Erik M; Thornton, James F

    2013-05-01

    Skin grafting in nasal reconstruction, long used by dermatologists, can provide superior results and can well be the "go to" procedure for nasal reconstruction. The upper two-thirds of the nose is composed of both flattened, featureless and often thin skin that is well recreated with defect-only full-thickness grafting. Skin grafting for the lower third of the nose has been practiced for years by dermatologists; over the last 4 to 5 years, it has been embraced by plastic surgeons. The patient and donor site selection is critical. Meticulous attention to graft selection, utilization of a no-touch technique during graft harvest and placement of surgical bolsters with through-and-through tacking sutures are essential to ensure 100% graft take and a successful aesthetic result.

  3. Emerging trends in social media and plastic surgery.

    Science.gov (United States)

    Gould, Daniel J; Leland, Hyuma A; Ho, Adelyn L; Patel, Ketan M

    2016-12-01

    Social media has increasingly changed the landscape of medicine and surgery and is rapidly expanding its influence in most peoples' lives. The average person spends nearly 2 hours per day using social media, consuming information about everything from family updates to entertainment news to presidential elections. The concentration of consumers on social media platforms has resulted in direct medicine and medical products marketing to consumers. Similarly, social media is increasingly becoming a platform for interaction between physicians and potential patients. Some physicians have taken this opportunity to better educate patients, while allowing patients to learn more about their surgeons online. These tools can increase internet traffic online to bonafide internet sites, as well as bolster marketing for many hospitals, hospital systems, and individual doctors. It can also serve to increase knowledge about procedures and conditions through direct outreach to patients. Social media is a powerful tool which needs to be utilized wisely to avoid pitfalls.

  4. A novel way to treat skin tears.

    Science.gov (United States)

    Moradian, Scott; Klapper, Andrew M

    2016-04-01

    Skin tears are one of the most commonly treated wounds in the elderly population. In their most basic form, they are essentially traumatic random pattern flaps. We postulate that the injured blood flow to these skin flaps should be ignored and the tissue should be treated as a skin graft. A case report is presented of an 86-year-old female with an 8 × 3·5 cm skin tear to her right upper extremity after a hip fracture. In addition to conventional wound closure strips re-approximating the tissues, a disposable negative pressure wound therapy device was placed to act as bolster. Upon its removal on day 5, the opposed skin tear tissue was found to be 100% viable. We therefore propose that this update may be an improvement over classical skin tear treatments and should be followed up with a case series.

  5. To discover or to create: metaphors and the true self.

    Science.gov (United States)

    Schlegel, Rebecca J; Vess, Matthew; Arndt, Jamie

    2012-08-01

    Three studies examined how endorsement of self-discovery and self-creation metaphors influences belief in the true self and its use as meaning source. It was hypothesized that discovery metaphors contribute to belief in the true self and bolster the relationship between true self-knowledge and meaning. Study 1 supported the hypothesis that discovery is positively associated with belief in the true self among a sample of college students (N = 311). Studies 2 and 3 extended the analysis by showing that the discovery metaphor also facilitates perceptions of meaning and the use of the true self specifically as a source of meaning in a second sample of college students (N = 75) as well as an adult sample of university employees (N = 173). Implications for understanding what enables the true self to infuse life with meaning, as well as an individual differences approach to metaphoric cognition, are discussed.

  6. The Relationship Between Psychopathology and a Hierarchical Model of Normal Personality Traits: Evidence From a Psychiatric Patient Sample.

    Science.gov (United States)

    Uliaszek, Amanda A; Al-Dajani, Nadia; Bagby, R Michael

    2015-12-01

    Shifts in the conceptualization of psychopathology have favored a dimensional approach, with the five-factor model (FFM) playing a prominent role in this research. However, reservations about the utility of the FFM in differentiating disorders have risen. In the current investigation, a "bottom-up" analytical method was used to ascertain the hierarchical structure of personality, with investigation of the specificity of the traits in categorizing diagnostic categories across an expanded array of psychiatric disorders. Following earlier investigations, which used a hierarchical structural approach, this study presents new results relating to the differentiation of several forms of psychopathology not included in these earlier analyses--bipolar disorder, psychotic disorders, problem gambling, posttraumatic stress disorder, and somatoform disorders--across distinct levels of a personality hierarchy based on the FFM. These results bolster the argument for the use of FFM personality traits in characterizing and differentiating psychiatric diagnostic groups.

  7. How a new 'public plan' could affect hospitals' finances and private insurance premiums.

    Science.gov (United States)

    Dobson, Allen; DaVanzo, Joan E; El-Gamil, Audrey M; Berger, Gregory

    2009-01-01

    Two key health reform bills in the House of Representatives and Senate include the option of a "public plan" as an additional source of health coverage. At least initially, the plan would primarily be structured to cover many of the uninsured and those who now have individual coverage. Because it is possible, and perhaps even likely, that this new public payer would pay less than private payers for the same services, such a plan could negatively affect hospital margins. Hospitals may attempt to recoup losses by shifting costs to private payers. We outline the financial pressures that hospitals and private payers could experience under various assumptions. High uninsured enrollment in a public plan would bolster hospital margins; however, this effect is reversed if the privately insured enter a public plan in large proportions, potentially stressing the hospital industry and increasing private insurance premiums.

  8. Anatomical basis of dimple creation - A new technique: Our experience of 100 cases

    Directory of Open Access Journals (Sweden)

    A R Lari

    2012-01-01

    Full Text Available Background: Cheek dimples are usually considered as an attractive feature of facial beauty. Unfortunately, not all beautiful girls have dimples. Literature on dimple creation surgery is sparse. Aims: We used a new and simple technique for dimple creation, passing a transcutaneous bolster stitch after scraping off the dermis of all mucomuscular attachments. Our aim was to analyse the positive and negative findings of this technique. Materials and Methods: We used this procedure in creation of 100 dimples under local anaesthesia as a daycare procedure and analysed the results. Results and Conclusion: This procedure is safe, reliable and easily reproducible. As no tissue is excised, chances of bleeding and haematoma formation are negligible. With this procedure, the patient satisfaction rate is very high, and patients seen long time after surgery continue to be pleased with their surgically created dimples.

  9. Closed incision management with negative pressure wound therapy (CIM): biomechanics.

    Science.gov (United States)

    Wilkes, Robert Peyton; Kilpad, Deepak V; Zhao, Yabin; Kazala, Richard; McNulty, Amy

    2012-03-01

    A novel closed incision management with negative pressure wound therapy (CIM) has been developed for convenient use with closed incisions that has the potential to be beneficial for patients at risk for postoperative complications. Incisions are typically under lateral tension. This study explored the biomechanical mechanisms by which integrity of the incisional closure is enhanced by CIM. CIM was hypothesized to affect local stresses around closed incisions in a beneficial manner. Finite element analyses (FEA) indicated that application of CIM decreased the lateral stresses ~50% around the incision and changed the direction of the stresses to a distribution that is typical of intact tissue. Bench evaluations corroborated findings that CIM significantly increased the force required to disrupt the closed incision by ~50% as compared with closure alone. In conclusion, using 2 FEAs and bench modeling, CIM was shown to reduce and normalize tissue stresses and bolster appositional forces at the incision.

  10. Halogen Bonding Promotes Higher Dye-Sensitized Solar Cell Photovoltages.

    Science.gov (United States)

    Simon, Sarah J C; Parlane, Fraser G L; Swords, Wesley B; Kellett, Cameron W; Du, Chuan; Lam, Brian; Dean, Rebecca K; Hu, Ke; Meyer, Gerald J; Berlinguette, Curtis P

    2016-08-24

    We report here an enhancement in photovoltage for dye-sensitized solar cells (DSSCs) where halogen-bonding interactions exist between a nucleophilic electrolyte species (I(-)) and a photo-oxidized dye immobilized on a TiO2 surface. The triarylamine-based dyes under investigation showed larger rate constants for dye regeneration (kreg) by the nucleophilic electrolyte species when heavier halogen substituents were positioned on the dye. The open-circuit voltages (VOC) tracked these kreg values. This analysis of a homologous series of dyes that differ only in the identity of two halogen substituents provides compelling evidence that the DSSC photovoltage is sensitive to kreg. This study also provides the first direct evidence that halogen-bonding interactions between the dye and the electrolyte can bolster DSSC performance.

  11. The theological paraphrasing of history: The Exodus tradition in the Wisdom of Solomon

    Directory of Open Access Journals (Sweden)

    Hendrik L. Bosman

    2012-11-01

    Full Text Available This study of the reinterpretation of the exodus tradition in the Wisdom of Solomon investigated the possibility that the reinterpretation entailed the alignment of history and wisdom. To come to grips with this alignment, attention had to be paid to its Greco-Roman context, whilst also taking into consideration the literary and theological structure of the Wisdom of Solomon, as well as its rhetoric and genre. In a theologically creative manner, Wisdom (as divine personification and history (as memories of salvation during the Exodus were combined in the Wisdom of Solomon to convince the Jews in the diaspora that justice would prevail – not only in this life but also thereafter. By means of poetic imagery, rhetorical skill, historical reinterpretation and imaginative wisdom theology, religious identity were not only bolstered to resist a dominant Greco-Roman culture but also to develop a positive view of creation according to the values of wisdom exemplified by the reinterpreted Exodus traditions.

  12. Linking Europa's plume activity to tides, tectonics, and liquid water

    CERN Document Server

    Rhoden, Alyssa R; Roth, Lorenz; Retherford, Kurt

    2015-01-01

    Much of the geologic activity preserved on Europa's icy surface has been attributed to tidal deformation, mainly due to Europa's eccentric orbit. Although the surface is geologically young (30 - 80 Myr), there is little information as to whether tidally-driven surface processes are ongoing. However, a recent detection of water vapor near Europa's south pole suggests that it may be geologically active. Initial observations indicated that Europa's plume eruptions are time-variable and may be linked to its tidal cycle. Saturn's moon, Enceladus, which shares many similar traits with Europa, displays tidally-modulated plume eruptions, which bolstered this interpretation. However, additional observations of Europa at the same time in its orbit failed to yield a plume detection, casting doubt on the tidal control hypothesis. The purpose of this study is to analyze the timing of plume eruptions within the context of Europa's tidal cycle to determine whether such a link exists and examine the inferred similarities and...

  13. Advanced Supersonic Nozzle Concepts: Experimental Flow Visualization Results Paired With LES

    Science.gov (United States)

    Berry, Matthew; Magstadt, Andrew; Stack, Cory; Gaitonde, Datta; Glauser, Mark; Syracuse University Team; The Ohio State University Team

    2015-11-01

    Advanced supersonic nozzle concepts are currently under investigation, utilizing multiple bypass streams and airframe integration to bolster performance and efficiency. This work focuses on the parametric study of a supersonic, multi-stream jet with aft deck. The single plane of symmetry, rectangular nozzle, displays very complex and unique flow characteristics. Flow visualization techniques in the form of PIV and schlieren capture flow features at various deck lengths and Mach numbers. LES is compared to the experimental results to both validate the computational model and identify limitations of the simulation. By comparing experimental results to LES, this study will help create a foundation of knowledge for advanced nozzle designs in future aircraft. SBIR Phase II with Spectral Energies, LLC under direction of Barry Kiel.

  14. Learning by Doing

    DEFF Research Database (Denmark)

    Liu, Fei; Xiao, Bo Sophia; Lim, Eric T. K.

    2016-01-01

    Information search is becoming increasingly demanding due to the booming of Consumer Generated Content (CGC) in online environment. This has led to growing scholarly interest in designing search features to accommodate diverse user preferences. Drawing on the Theory of Affordance Informativity, we...... advance ostensive informativity and performative informativity as focal mechanisms for search features to convey actions afforded to users. We further put forth a typology of search features that is grounded in both dimensions of search affordance informativities. Next, we construct a research framework...... that depicts how search affordance informativity bolsters information search performance. By conducting a field experiment on our custom-made online restaurant review website, we discovered that performative informativity increases search result anticipation and reduces search costs whereas ostensive...

  15. Astrophysical, Geochemical, Geophysical and Biological Limits on Planet Habitability

    Science.gov (United States)

    Lineweaver, C.

    2014-03-01

    For life forms like us, the most important feature of the Earth is its habitability. Understanding habitability and using that knowledge to locate the nearest habitable planet may be crucial for our survival as a species. Over the past decade, expectations that the universe could be filled with habitable planets have been bolstered by the increasingly large overlap between terrestrial environments known to harbor life and the variety of environments on newly detected rocky exoplanets. The inhabited and uninhabited regions on Earth tell us that temperature and the presence of water are the main constraints that can be used in a habitability classification scheme for rocky planets. Our compilation and review of recent exoplanet detections suggests that the fraction of stars with planets is ~ 100%, and that the fraction with rocky planets may be comparably large. We review extensions to the circumstellar habitable zone including an abiogenesis habitable zone and the galactic habitable zone.

  16. Organizational Maturity in Competitive Intelligence – The Case of a Brazilian Financial Institution

    Directory of Open Access Journals (Sweden)

    Leonel Cezar Rodrigues

    2014-04-01

    Full Text Available This study aims at characterizing and identifying the degree of maturity in Competitive Intelligence (CI of a financial organization from a developing country, abyding by a maturity model in the literature. To do this research, the chosen method was the case study. Data were collected among 4 distinct áreas of the organization: Marketing, Physical Security; International Relations; and Risk management.  Main results indicate that two áreas show maturity in CI, level 1 – Informal. The othe two show degree of maturity in CI, level 2 – Formal. Conclusions of the study support coherence of criteria and elements that bolster the logic of the selected model and the decentralized structure of CI in the studied organization, showing, in an yet intuitive way, to hold an advanced CI operating model.

  17. Translational PK/PD modeling to increase probability of success in drug discovery and early development.

    Science.gov (United States)

    Lavé, Thierry; Caruso, Antonello; Parrott, Neil; Walz, Antje

    In this review we present ways in which translational PK/PD modeling can address opportunities to enhance probability of success in drug discovery and early development. This is achieved by impacting efficacy and safety-driven attrition rates, through increased focus on the quantitative understanding and modeling of translational PK/PD. Application of the proposed principles early in the discovery and development phases is anticipated to bolster confidence of successfully evaluating proof of mechanism in humans and ultimately improve Phase II success. The present review is centered on the application of predictive modeling and simulation approaches during drug discovery and early development, and more specifically of mechanism-based PK/PD modeling. Case studies are presented, focused on the relevance of M&S contributions to real-world questions and the impact on decision making.

  18. Perceived control qualifies the effects of threat on prejudice.

    Science.gov (United States)

    Greenaway, Katharine H; Louis, Winnifred R; Hornsey, Matthew J; Jones, Janelle M

    2014-09-01

    People sometimes show a tendency to lash out in a prejudiced manner when they feel threatened. This research shows that the relationship between threat and prejudice is moderated by people's levels of perceived control: Threat leads to prejudice only when people feel concurrently low in control. In two studies, terrorist threat was associated with heightened prejudice among people who were low in perceived control over the threat (Study 1; N = 87) or over their lives in general (Study 2; N = 2,394), but was not associated with prejudice among people who were high in perceived control. Study 3 (N = 139) replicated this finding experimentally in the context of the Global Financial Crisis. The research identifies control as an important ingredient in threatening contexts that, if bolstered, can reduce general tendencies to lash out under threat.

  19. Are effects of emotion expression on trait impressions mediated by babyfaceness? Evidence from connectionist modeling.

    Science.gov (United States)

    Zebrowitz, Leslie A; Kikuchi, Masako; Fellous, Jean-Marc

    2007-05-01

    Two studies provided evidence that bolsters the Marsh, Adams, and Kleck hypothesis that the morphology of certain emotion expressions reflects an evolved adaptation to mimic babies or mature adults. Study 1 found differences in emotion expressions' resemblance to babies using objective indices of babyfaceness provided by connectionist models that are impervious to overlapping cultural stereotypes about babies and the emotions. Study 2 not only replicated parallels between impressions of certain emotions and babies versus adults but also showed that objective indices of babyfaceness partially mediated impressions of the emotion expressions. babyface effects were independent of strong effects of attractiveness, and babyfaceness did not mediate impressions of happy expressions, to which the evolutionary hypothesis would not apply.

  20. Modeling of nanotoxicity molecular interactions of nanomaterials with bionanomachines

    CERN Document Server

    Zhou, Ruhong

    2015-01-01

    This book provides a comprehensive overview of the fundamentals of nanotoxicity modeling and its implications for the development of novel nanomedicines. It lays out the fundamentals of nanotoxicity modeling for an array of nanomaterial systems, ranging from carbon-based nanoparticles to noble metals, metal oxides, and quantum dots. The author illustrates how molecular (classical mechanics) and atomic (quantum mechanics) modeling approaches can be applied to bolster our understanding of many important aspects of this critical nanotoxicity issue. Each chapter is organized by types of nanomaterials for practicality, making this an ideal book for senior undergraduate students, graduate students, and researchers in nanotechnology, chemistry, physics, molecular biology, and computer science. It is also of interest to academic and industry professionals who work on nanodrug delivery and related biomedical applications, and aids readers in their biocompatibility assessment efforts in the coming age of nanotechnology...

  1. Land use and management change under climate change adaptation and mitigation strategies: a U.S. case study

    Science.gov (United States)

    Mu, Jianhong E.; Wein, Anne; McCarl, Bruce

    2015-01-01

    We examine the effects of crop management adaptation and climate mitigation strategies on land use and land management, plus on related environmental and economic outcomes. We find that crop management adaptation (e.g. crop mix, new species) increases Greenhouse gas (GHG) emissions by 1.7 % under a more severe climate projection while a carbon price reduces total forest and agriculture GHG annual flux by 15 % and 9 %, respectively. This shows that trade-offs are likely between mitigation and adaptation. Climate change coupled with crop management adaptation has small and mostly negative effects on welfare; mitigation, which is implemented as a carbon price starting at $15 per metric ton carbon dioxide (CO2) equivalent with a 5 % annual increase rate, bolsters welfare carbon payments. When both crop management adaptation and carbon price are implemented the effects of the latter dominates.

  2. Fitting in or opting out: A review of key social-psychological factors influencing a sense of belonging for women in physics

    Science.gov (United States)

    Lewis, Karyn L.; Stout, Jane G.; Pollock, Steven J.; Finkelstein, Noah D.; Ito, Tiffany A.

    2016-12-01

    [This paper is part of the Focused Collection on Gender in Physics.] A number of cultural, social, environmental, and biological factors have been suggested to explain women's relatively lower representation in physics and other science, technology, engineering, and math (STEM) fields. Given its persistence, the causes of gender disparities are likely to be complex and multiply determined. In this review paper, we discuss how a sense of belonging relates to women's interest, persistence, and achievement in physics. We explore what it means to "fit in" and belong in academic contexts, the situational and interpersonal antecedents to belonging, and the consequences of a lack of belonging. We review the empirical evidence for the efficacy of interventions designed to bolster a sense of belonging. Based on these interventions we conclude the paper with a number of practical recommendations to affirm women's sense of belonging and create more welcoming and inclusive physics environments for all students.

  3. Will the new Australian health privacy law provide adequate protection?

    Science.gov (United States)

    Bomba, David; Hallit, George

    2002-01-01

    Amendments to the original Privacy Act (1988) come at a key point in time, as a national medical record system looms on the Australian horizon. Changes to The Privacy Act have the potential to define a level of information privacy prior to the implementation of such a system. We have therefore collected expert opinions on the ability of the Health Privacy Guidelines (enacted in December 2001 under The Privacy Act and hereafter more specifically known as Health Privacy Legislation) to ensure the privacy and security of patient information. We conclude that the legislation is flawed in its capacity to withstand an increasingly corporatised health sector. Deficiencies in consent requirements, together with feeble enforcement capabilities, mean The Legislation cannot effectively ensure that personally identifiable information will not end up in corporate third party hands. To significantly bolster the new legislation, we argue that it should be supplemented with explicit health data legislation and privacy auditing.

  4. A Cosmic Ray Resolution to the Superbubble Energy-Crisis

    CERN Document Server

    Butt, Yousaf M

    2008-01-01

    Superbubbles (SBs) are amongst the greatest injectors of energy into the Galaxy, and have been proposed to be the acceleration site of Galactic cosmic rays. They are thought to be powered by the fast stellar winds and powerful supernova explosions of massive stars in dense stellar clusters and associations. Observations of the SB 'DEM L192' in the neighboring Large Magellenic Cloud (LMC) galaxy show that it contains only about one-third the energy injected by its constituent stars via fast stellar winds and supernovae. It is not yet understood where the excess energy is going, thus, the so-called 'energy crisis'. We show here that it is very likely that a significant fraction of the unaccounted for energy is being taken up in accelerating cosmic rays, thus bolstering the argument for the SB origin of cosmic rays.

  5. BACK IN TOWN

    Institute of Scientific and Technical Information of China (English)

    Wu Chunsi

    2012-01-01

    The United States has shifted its focus to the Asia-Pacific.This momentous move has sparked a heated debate in the Chinese media and academic community on a number of critical issues:Is the Obama administration's new AsiaPacific strategy in opposition to China? What will be the implications of this strategy? And how will China and the United States interact with each other in the Asia-Pacific region?New strategy After a decade focused on events in the Middle East,the United States has recently bolstered its presence in the Asia-Pacific,though many U.S.scholars argue the United States has never left the region.

  6. First detection of Agrilus planipennis in Connecticut made by monitoring Cerceris fumipennis (Crabronidae colonies

    Directory of Open Access Journals (Sweden)

    Claire Rutledge

    2013-04-01

    Full Text Available Smoky winged beetle bandits, Cerceris fumipennis Say, digger wasps in the family Hymenoptera: Crabronidae: Cercerini, provision their underground nests with adult metallic wood-boring beetles (Coleoptera: Buprestidae. Researchers, as well as engaged community volunteers, in several states have monitored female wasps returning to their nests as a means to detect invasive buprestid species. In this paper, we report the first detection of emerald ash borer (Agrilus planipennis Fairemore, an invasive beetle responsible for killing millions of ash trees in North America, in Connecticut by C. fumipennis and discuss its relationship to A. planipennis survey efforts by other modalities in the state. We also report detections of A. planipennis by C. fumipennis in Illinois, New York and Ontario; all of which were made after it was known the beetle was in the area. These findings support the use of C. fumipennis as a biomonitoring tool and bolster the use of engaged volunteers.

  7. Application of Proteomics and Lipid Studies in Environmental Biotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Mukhopadhyay, Aindrila

    2008-08-12

    The overview of changes in protein levels or states in response to a growth condition, stress, mutation or metabolic engineering is invaluable in understanding the physiology of a microbial system. The lipid profile of the cell is similarly a valuable diagnostic of the cellular response and health, especially in context of survival in a fluctuating environment. To obtain comprehensive cellular models, post-transcriptional cell wide surveys at the levels of proteins and lipids are required. Both these fields have been greatly bolstered by the development of high throughput methods using mass spectrometry. Multiple strategies now exist for the identification of proteins, and numerous workflows to quantify protein abundance have also been developed. Cellular profiling such as these allows us to assess the potential of a microbial system for environmental applications such as bioremediation and bio-energy.

  8. Use your words!

    Science.gov (United States)

    Shapiro, Theodore

    2004-01-01

    "Use your words!" is a phrase admonishing preschoolers to divert their action-proneness to thought and language. Freud's injunction against acting out had a similar aim, placing control over drives in the domain of "inner language." The twenty-first-century psychoanalyst continues to employ models that depend on mentalization viewed from two angles-neural inhibition and social discourse. Psychoanalysts bolster their position by borrowing from the basic scientific work in each area. The recent focus on enactments, intersubjectivity, and social constructivism is reconsidered from an historical vantage point, as is the work that seeks to reconcile recent findings in neuroimaging and cognitive neuroscience. Freud's vision included a holistic hope that a comprehensive science of human beings might be achieved by understanding derived from biological inquiry and the artifacts of social and cultural narratives. The author's experience in both domains is recounted, and a new reconciliation of disparate approaches is offered in linguistic complementarity.

  9. Rapid control of male typical behaviors by brain-derived estrogens.

    Science.gov (United States)

    Cornil, Charlotte A; Ball, Gregory F; Balthazart, Jacques

    2012-10-01

    Beside their genomic mode of action, estrogens also activate a variety of cellular signaling pathways through non-genomic mechanisms. Until recently, little was known regarding the functional significance of such actions in males and the mechanisms that control local estrogen concentration with a spatial and time resolution compatible with these non-genomic actions had rarely been examined. Here, we review evidence that estrogens rapidly modulate a variety of behaviors in male vertebrates. Then, we present in vitro work supporting the existence of a control mechanism of local brain estrogen synthesis by aromatase along with in vivo evidence that rapid changes in aromatase activity also occur in a region-specific manner in response to changes in the social or environmental context. Finally, we suggest that the brain estrogen provision may also play a significant role in females. Together these data bolster the hypothesis that brain-derived estrogens should be considered as neuromodulators.

  10. Driving Their Way Out

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    China joined a worldwide effort to salvage its economy from being shattered by the devastating financial turmoil. Since the very beginning of this year, it has been working out a string of revitalization plans to bolster the nation’s backbone industries, including autos, iron and steel, shipbuilding, petrochemical, textile, equipment manufacturing, electronic and IT, nonferrous metals and light industries. By a rough estimation, those heavyweights jointly produce one third of China’s gross domestic product (GDP), create 80 percent of all added value of the industrial sector, and account for 35 percent of the nation’s tax revenue. In this issue, Beijing Review analyzes four of those plans, offering our readers a quick glimpse of how China intends to revive its flagging economy.

  11. Adaptationism fails to resolve Fermi's paradox

    Directory of Open Access Journals (Sweden)

    Ćirković Milan M.

    2005-01-01

    Full Text Available One of the most interesting problems in the nascent discipline of astrobiology is more than half-century old Fermi's paradox: why, considering extraordinary young age of Earth and the Solar System in the Galactic context, don't we perceive much older intelligent communities or signposts of their activity? In spite of a vigorous research activity in recent years, especially bolstered by successes of astrobiology in finding extrasolar planets and extremophiles, this problem (also known as the "Great Silence" or "astrosociological" paradox remains as open as ever. In a previous paper, we have discussed a particular evolutionary solution suggested by Karl Schroeder based on the currently dominant evolutionary doctrine of adaptationism. Here, we extend that discussion with emphasis on the problems such a solution is bound to face, and conclude that it is ultimately quite unlikely. .

  12. Gallinacin and Fowlicidin: Two Promising Antimicrobial Peptides in ChickensAND#8212;A Review

    Directory of Open Access Journals (Sweden)

    C. S. Mukhopadhyaya

    2010-12-01

    Full Text Available Antimicrobial peptides (AMP which have been identified in almost all groups of organisms, are the small cationic molecules that recognize the pathogen associated molecular patterns of the microbes. In chicken two main AMPs that play significant roles in bolstering the innate immunity are gallinacins and fowlicidins, which are the functional analogues of the mammalian beta-defensins and cathelicidins. Gallinacin identifies the Gram negative bacteria while fowlicidin exerts broad spectral activity. The basic mechanism of action is by far similar in both groups of AMPs. The ‘docking sites’ of these antimicrobial peptides includes the “lipid A” moiety of lipo polysaccharides, lipo-teichoic acids, anionic membrane phospholipids on bacterial surfaces. These AMPs block the DNA replication and protein synthesis in bacteria causing death of the microbe. Researchers have identified reproducible molecular markers of those peptides for selection of disease resistant stock of chickens. [Vet. World 2010; 3(6.000: 297-300

  13. DYNAMICS OF FREIGHT CARS ON BOGIES MODEL 18-1711 WITH DIFFERENT WEDGE DE-SIGNS OF SPRING SUSPENSION

    Directory of Open Access Journals (Sweden)

    N. B. Mankevych

    2014-01-01

    Full Text Available Purpose. To analyze the results of the study of dynamic parameters of a gondola car, model 12-1704-04 with axle load 23.5 ton in bogies, models 18-1750 and two gondola cars, model 12-1905 with axial load of 25 ton, one of which is equipped with bogies, model 18-1711 with friction wedges of spring suspension with spatial form with increased angle to the horizontal line of intersection of the contact surfaces between the wedge and bolster, the other gondola car, model 12-1905 is equipped with bogies of the same model on which the friction wedges fitted with a flat form of contact surface. It has an angle of inclination like a wedge of bogie, model 18-100. On the basis of the obtained results to draw conclusions about the feasibility of unification design bogie bolster, model 18-1711 with bogie, model 18-100 by contact surfaces with elements of spring suspension. Methodology. Research on dynamic performance of cars was performed during running dynamic tests of specimens of freight cars in experimental train consisting of two locomotives, a laboratory, and three gondola cars of the above mentioned models. Findings. Main results of dynamic studies are presented as graphs of indicators on the speed of the train and the experimental evidence that the freight gondola cars on bogies, model 18-1711 with flat-shaped wedges, in most cases are better than the others. Originality. Research results of cars on bogies, model 18-1711 were obtained. They let assess the dependence of the dynamic performance of the car from the design of the friction wedges of spring suspension. Practical value. Cast parts of bogie, model 18-1711 with 25 ton axle load can be used as a replacement of defective parts of bogie, model 18-100 and its analogs.

  14. U-2 with fictitious NASA markings to support CIA cover story for pilot Gary Powers, shot down over S

    Science.gov (United States)

    1960-01-01

    After Francis Gary Powers was shot down over the Soviet Union during a CIA spy flight on 1 May 1960, NASA issued a press release with a cover story about a U-2 conducting weather research that may have strayed off course after the pilot 'reported difficulties with his oxygen equipment.' To bolster the cover-up, a U-2 was quickly painted in NASA markings, with a fictitious NASA serial number, and put on display for the news media at the NASA Flight Research Center at Edwards Air Force Base on 6 May 1960. The next day, Soviet Premier Nikita Kruschev exposed the cover-up by revealing that the pilot had been captured, and espionage equipment had been recovered from the wreckage. 7 May 1956 - NACA Director Dr. Hugh L. Dryden issues a press release stating that U-2 aircraft are conducting weather research for NACA with Air Force support from Watertown, Nevada. 22 May 1956 - A second press release is issued with cover story for U-2 aircraft operating overseas. 1 May 1960 - Francis Gary Powers is shot down near Sverdlovsk. 6 May 1960 - U-2 with fictitious NASA serial number and NASA markings is shown to news media to bolster cover story of NASA weather research flights with U-2. 7 May 1960 - Soviet Premier Kruschev announces capture and confession of Powers. 1960 - Dr. Hugh L. Dryden tells senate committee that some 200 U-2 flights carrying NASA weather instrumentation have taken place since 1956. 2 April 1971 - NASA receives two U-2C aircraft for high-altitude research.

  15. A feature selection approach for identification of signature genes from SAGE data

    Directory of Open Access Journals (Sweden)

    Silva Paulo JS

    2007-05-01

    Full Text Available Abstract Background One goal of gene expression profiling is to identify signature genes that robustly distinguish different types or grades of tumors. Several tumor classifiers based on expression profiling have been proposed using microarray technique. Due to important differences in the probabilistic models of microarray and SAGE technologies, it is important to develop suitable techniques to select specific genes from SAGE measurements. Results A new framework to select specific genes that distinguish different biological states based on the analysis of SAGE data is proposed. The new framework applies the bolstered error for the identification of strong genes that separate the biological states in a feature space defined by the gene expression of a training set. Credibility intervals defined from a probabilistic model of SAGE measurements are used to identify the genes that distinguish the different states with more reliability among all gene groups selected by the strong genes method. A score taking into account the credibility and the bolstered error values in order to rank the groups of considered genes is proposed. Results obtained using SAGE data from gliomas are presented, thus corroborating the introduced methodology. Conclusion The model representing counting data, such as SAGE, provides additional statistical information that allows a more robust analysis. The additional statistical information provided by the probabilistic model is incorporated in the methodology described in the paper. The introduced method is suitable to identify signature genes that lead to a good separation of the biological states using SAGE and may be adapted for other counting methods such as Massive Parallel Signature Sequencing (MPSS or the recent Sequencing-By-Synthesis (SBS technique. Some of such genes identified by the proposed method may be useful to generate classifiers.

  16. Bounded agency in humanitarian settings: a qualitative study of adherence to antiretroviral therapy among refugees situated in Kenya and Malaysia.

    Science.gov (United States)

    Mendelsohn, Joshua B; Rhodes, Tim; Spiegel, Paul; Schilperoord, Marian; Burton, John Wagacha; Balasundaram, Susheela; Wong, Chunting; Ross, David A

    2014-11-01

    HIV-positive refugees confront a variety of challenges in accessing and adhering to antiretroviral therapy (ART) and attaining durable viral suppression; however, there is little understanding of what these challenges are, how they are navigated, or how they may differ across humanitarian settings. We sought to document and examine accounts of the threats, barriers and facilitators experienced in relation to HIV treatment and care and to conduct comparisons across settings. We conducted semi-structured interviews among a purposive sample of 14 refugees attending a public, urban HIV clinic in Kuala Lumpur, Malaysia (July-September 2010), and 12 refugees attending a camp-based HIV clinic in Kakuma, Kenya (February-March 2011). We used framework methods and between-case comparison to analyze and interpret the data, identifying social and environmental factors that influenced adherence. The multiple issues that threatened adherence to antiretroviral therapy or precipitated actual adherence lapses clustered into three themes: "migration", "insecurity", and "resilience". The migration theme included issues related to crossing borders and integrating into treatment systems upon arrival in a host country. Challenges related to crossing borders were reported in both settings, but threats pertaining to integration into, and navigation of, a new health system were exclusive to the Malaysian setting. The insecurity theme included food insecurity, which was most commonly reported in the Kenyan setting; health systems insecurity, reported in both settings; and emotional insecurity, which was most common in the Kenyan setting. Resilient processes were reported in both settings. We drew on the concept of "bounded agency" to argue that, despite evidence of personal and community resilience, these processes were sometimes insufficient for overcoming social and environmental barriers to adherence. In general, interventions might aim to bolster individuals' range of action with

  17. Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures

    Directory of Open Access Journals (Sweden)

    Antonio Augusto Velasco e Cruz

    2015-12-01

    Full Text Available ABSTRACT Purpose: To describe the use of a lid crease incision for upper eyelid margin rotation in cicatricial entropion combining internal traction on the anterior lamella, tarsotomy, and tarsal overlap without external sutures. Methods: Surgical description: The main steps of the procedure consisted of exposure of the entire tarsal plate up to the eyelashes followed by tarsotomy through the conjunctiva. A double-armed 6.0 polyglactin suture was then passed through the distal tarsal fragment to the marginal section of the orbicularis oculi muscle. As the sutures were tied, the distal tarsus advanced over the marginal section, and traction was exerted on the marginal strip of the orbicularis muscle. There were no bolsters or external knots. The pretarsal skin-muscle flap was closed with a 6.0 plain gut suture. Results: We used this procedure at a tertiary hospital in Saudi Arabia from 2013 to 2014. Sixty upper lids of 40 patients (23 women and 17 men were operated on, with an age range of 44-99 years [mean ± standard deviation (SD = 70.9 ± 13.01 years]. Bilateral surgery was performed on 21 patients. Follow-up ranged from 1 to 12 months (mean 3.0 ± 2.71 months. Forty percent of the patients (24 lids had more than 3 months' follow-up. The postoperative lid margin position was good in all cases. Trichiasis (two lashes was observed in only one patient with unilateral entropion on the medial aspect of the operated lid. Conclusions: The upper lid margin can be effectively rotated through a lid crease incision with internal sutures. The technique combines the main mechanisms of the Wies and Trabut approaches and avoids the use of bolsters or external sutures, which require a second consultation to be removed. Some other lid problems, such as ptosis, retraction, or dermatochalasis, can be concomitantly addressed during the procedure.

  18. The Australian Hydrogen and Fuel Cells Education Program

    Energy Technology Data Exchange (ETDEWEB)

    Luigi Bonadio [Senior Consultant Luigi Bonadio and Associates (Australia)

    2006-07-01

    The next generation of engineers and scientists will face great technical, economic and political challenges to satisfy increasing demands for a secure, reliable and affordable global energy system that maintains and enhances current standards of living. The Australian Hydrogen and Fuel Cells Education Program aims to bolster the quality and relevance of primary and secondary school teaching in emerging areas of science, technology and environmental/sustainability studies using hydrogen, in its capacity as a versatile energy carrier, as the educational basis for teacher and student learning. Critical advances in specific areas of hydrogen production, distribution, storage and end-use technologies arise when students are engaged to develop and apply a broad range of disciplinary and interdisciplinary knowledge and practical skills. A comprehensive hydrogen and fuel cell technology teaching module will be developed to complement existing fuels and energy curricula across Australian schools. The pilot program will be delivered via the collaboration of nine trial schools, a broad range of technical and pedagogy experts and representatives of professional bodies and industry. The program features essential and extensive teacher consultation, a professional learning and development course, industry site visits and a dedicated research and evaluation study. This initiative aims to bolster teacher literacy and student participation in the design, construction and operation of various hydrogen and fuel cell devices and extended activities. Students will reflect on and formally present their learning experiences via several dedicated fora including an awards ceremony where outstanding performance of leading schools, teachers and student groups within the cluster will be acknowledged. (authors)

  19. Free digital artery flap: an ideal flap for large finger defects in situations where local flaps are precluded.

    Science.gov (United States)

    Wong, Chin-Ho; Teoh, Lam-Chuan; Lee, Jonathan Y-L; Yam, Andrew K-T; Khoo, David B-A; Yong, Fok-Chuan

    2008-03-01

    The heterodigital arterialized flap is increasingly accepted as a flap of choice for reconstruction of large finger wounds. However, in situations where the adjacent fingers sustained concomitant injuries, the use of this flap as a local flap is precluded. This paper describes our experience with the free digital artery flap as an evolution of the heterodigital arterialized flap. Four patients with large finger wounds were reconstructed with free digital artery flap. Our indications for digital artery free flap were concomitant injuries to adjacent fingers that precluded their use as donor sites. The arterial supply of the flap was from the digital artery and the venous drainage was from the dominant dorsal vein of the finger. The flap was harvested from the ulnar side of the finger. The digital nerve was left in situ to minimize donor morbidity. The donor site was covered with a full-thickness skin graft and secured with bolster dressings. Early intensive mobilization was implemented for all patients. All flaps survived. No venous congestion was noted and primary healing was achieved in all flaps. In addition to providing well-vascularized tissue for coverage of vital structures, the digital artery was also used as a flow-through flap for finger revascularization in one patient. Donor-site morbidity was minimal, with all fingers retaining protective pulp sensation and the distal and proximal interphalangeal joints retaining full ranges of motion. In conclusion, the free digital artery flap is a versatile flap that is ideal for coverage of large-sized finger defects in situations where local flaps are unavailable. Donor-site morbidity can be minimized by preservation of the digital nerve, firmly securing the skin graft with bolster dressings, and early mobilization of the donor finger.

  20. Development of a simplified finite element model of the 50th percentile male occupant lower extremity.

    Science.gov (United States)

    Schwartz, Doron; Moreno, Daniel P; Stitzel, Joel D; Gayzik, F Scott

    2014-01-01

    A simplified lower extremity model was developed using the geometry from the Global Human Body Models Consortium (GHBMC) 50th percentile male occupant model v4.1.1 (M50) as a base. This simplified model contains 31.4x103 elements and has structures that represent bone (assumed rigid) and soft tissue. This element total is substantially reduced compared to 117.7x103 elements in the original M50 lower extremity. The purpose of this simplified computational model is to output rapid kinematic and kinetic data when detailed structural response or injury prediction data is not required. The development process included evaluating the effects of element size, material properties, and contact definitions on total run time and response. Two simulations were performed to analyze this model; a 4.9 m/s knee bolster impact and a 6.9 m/s lateral knee impact using LS-DYNA R6.1.1. The 40 ms knee bolster impact and lateral knee impact tests required 5 and 7 minutes to run, respectively on 4 cores. The original detailed M50 lower extremity model required 94 and 112 minutes to run the same boundary conditions, on the same hardware, representing a reduction in run time of on average 94%. A quantitative comparison was made by comparing the peak force of the impacts between the two models. This simplified leg model will become a component in a simplified full body model of the seated, 50th percentile male occupant. The significantly reduced run time will be valuable for parametric studies with a full body finite element model.

  1. Fiscal and Macroeconomic Effects of Colombia`s Pension Reform Fiscal and Macroeconomic Effects of Colombia`s Pension Reform

    Directory of Open Access Journals (Sweden)

    Klaus Schmidt-Hebbel

    1997-03-01

    Full Text Available In 1994 Colombia started replacing its state-run and pay-as-you-go (PAYG pension system by a privately-run and fully-funded scheme. Numerical simulations for the government's reform transition reveal implicit PAYG debt levels and corresponding reform transition deficits that are high relative to other countries, considering that Colombia's old pension system was characterized by low coverage, low system maturity, and a young population.Simulation results show that output could increase by 10% due to higher future saving caused by financing the pension deficit by a fiscal contraction -but this would occur only in the very long term. Sooner and possibly larger gains could be reaped from higher employment and production in formal sectors, and the development of capital markets spurred by the reform. In addition, Colombia's new pension systemthat includes a redistributive pillar targeted at the poor -is potentially more equitable than the old scheme, To reap these efficiency and equity bellefits, however, the Colombian government would have to adopt complementary reforms. They include giving the private fully-funded pension pillar a commanding role, supporting the development of capital markets, and bolstering formal-sector employment by the reduction of deadweight tax burden of non-pension programs that are currently financed by payroll taxes on labor. In 1994 Colombia started replacing its state-run and pay-as-you-go (PAYG pension system by a privately-run and fully-funded scheme. Numerical simulations for the government's reform transition reveal implicit PAYG debt levels and corresponding reform transition deficits that are high relative to other countries, considering that Colombia's old pension system was characterized by low coverage, low system maturity, and a young population.Simulation results show that output could increase by 10% due to higher future saving caused by financing the pension deficit by a fiscal contraction -but this would

  2. 基于美国ASME标准的重载货车车体焊缝疲劳寿命预测%Fatigue life prediction for weld line in heavy freight carbody based on ASME standard

    Institute of Scientific and Technical Information of China (English)

    谢素明; 周晓坤; 李向伟; 李晓峰

    2012-01-01

    为寻求在设计阶段能较准确地预测重载货车车体焊缝的疲劳寿命评估方法,基于各种标准提供的分析方法对转炉616装甲钢T型焊接接头进行疲劳评估,通过与试验的对比表明,美国ASME标准中的等效结构应力法更能准确预测焊缝的疲劳寿命。为提高某重载运煤敞车车体焊缝的疲劳寿命,建立了包括焊缝在内的敞车车体有限元模型,基于等效结构应力法和AAR标准中的载荷谱,预测了车体关键焊缝的疲劳寿命,其薄弱部位与车体实际发生疲劳裂纹部位基本吻合,依据焊缝的结构应力分布规律的特点,提出的枕梁改进结构可使车体关键焊缝疲劳寿命提高1.7倍。%Aiming at finding a more exact method to predict weld line fatigue life in heavy freight carbody during design phase, the fatigue life of armor steel 616 Tee joint is analyzed by various standards. Comparing analysis results and experimental results,the equivalent structural stress method offered by ASME standard is of high accuracy and obvious advantage. A finite element model of a heavy freight carbody including key weld lines is built, fatigue life prediction for these weld lines is performed by means of the equivalent structural stress method and load spectrum of AAR,and weld line of more shorter fatigue life is basically coincident with that in-service carbody. The improved structure of bolsters is to be put forward on the basis of structural stress analysis at weld lines, and fatigue life of the bolsters weld line is increased by 1.7 times.

  3. Variability of ischiofemoral space dimensions with changes in hip flexion: an MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Adam C.; Howe, Benjamin M. [Mayo Clinic College of Medicine, Department of Radiology, Rochester, MN (United States); Hollman, John H.; Finnoff, Jonathan T. [Mayo Clinic College of Medicine, Department of Physical Medicine and Rehabilitation, Rochester, MN (United States)

    2017-01-15

    The primary aim of this study was to determine if ischiofemoral space (IFS) dimensions vary with changes in hip flexion as a result of placing a bolster behind the knees during magnetic resonance imaging (MRI). A secondary aim was to determine if IFS dimensions vary between supine and prone hip neutral positions. The study employed a prospective design. Sports medicine center within a tertiary care institution. Five male and five female adult subjects (age mean = 29.2, range = 23-35; body mass index [BMI] mean = 23.5, range = 19.5-26.6) were recruited to participate in the study. An axial, T1-weighted MRI sequence of the pelvis was obtained of each subject in a supine position with their hips in neutral and flexed positions, and in a prone position with their hips in neutral position. Supine hip flexion was induced by placing a standard, 9-cm-diameter MRI knee bolster under the subject's knees. The order of image acquisition (supine hip neutral, supine hip flexed, prone hip neutral) was randomized. The IFS dimensions were then measured on a separate workstation. The investigator performing the IFS measurements was blinded to the subject position for each image. The main outcome measurements were the IFS dimensions acquired with MRI. The mean IFS dimensions in the prone position were 28.25 mm (SD 5.91 mm, standard error mean 1.32 mm). In the supine hip neutral position, the IFS dimensions were 25.1 (SD 5.6) mm. The mean difference between the two positions of 3.15 (3.6) mm was statistically significant (95 % CI of the difference = 1.4 to 4.8 mm, t{sub 19} = 3.911, p =.001). The mean IFS dimensions in the hip flexed position were 36.9 (SD 5.7) mm. The mean difference between the two supine positions of 11.8 (4.1) mm was statistically significant (95 % CI of the difference = 9.9 to 13.7 mm, t{sub 19} = 12.716, p <.001). Our findings demonstrate that the IFS measurements obtained with MRI are dependent upon patient positioning with respect to hip flexion and

  4. Study of spherical alidade%球形照准架系统的研究

    Institute of Scientific and Technical Information of China (English)

    杨立保

    2012-01-01

    T model frame and U model frame are the common structure for alidade photoelectric theodolite.However, structure of alidade has changed as the application of photoelectric theodolite.In the marine environment, theodolite need to have the ability of the anti—salt, anti—corrosion, anti—moisture etc.Spherical structure can fully satisfy all these needs of theodolite.This paper presents the spherical alidade which is in the form of a spherical four—way and the arc - bol-ster structure, This paper introduces a sighting frame structure firstly.Detailed is made for aspects of division form of spherical four—way and finite element analysis.The structure of an arc—bolster is designed.Then a spherical four—way framework suitable for horizontal shafting is obtained. The maximum static deformation of the spherical four—way frame-work is 3.3μm when bearing 40kg load.The pointing accuracy of the horizontal shafting is less than 2" .The analysis and the test verify that the horizontal shafting with spherical four—way framework is stable and reliable%常见的地平式光电经纬仪的照准架分U型和T型两种结构,但是随着光电经纬仪应用领域的不断扩大,照准架的结构形式发生了很大变化.比如在海洋环境条件下,需要仪器具有防盐雾、防腐蚀、防潮湿的能力,由于球形结构恰好适应了这一需求.因此本文提出了一种球形四通结合弧形立柱结构的照准架形式.本文首先介绍了照准架的结构形式,然后对球形四通进行分割设计并进行有限元受力分析.独创性的设计了弧形立柱的结构.得到一个球形照准架,在40kg负载的情况下最大变形3.3μm,轴系精度小于2″,完全满足指标要求.

  5. Computer Studies Of The Isleworth And Louvre Mona Lisas

    Science.gov (United States)

    Asmus, John F.

    1989-07-01

    One of the most pervasive problems in the scholarship of classical paintings is that of authenticity. Traditionally, the attribution of a work of art rests on the subjective opinion of an art historian bolstered by scientific data pertaining to the types and possibly the ages of the materials of the artwork. To expand the range of technical information that may be applied to the painting authentication problem, the methods of computer image processing (IP) have been employed to compare the techniques in two paintings. One is the Mona Lisa del Gioconda by Leonardo da Vinci. The other is known as the Isleworth Mona Lisa and has also been attributed to Leonardo by a few scholars. Computer IP was used to compare statistical and geometrical features of the two paintings. It emerged that the Isleworth work is not a copy of the Louvre painting but does have numerous similarities in composition and execution. These findings lend support to the theory that the Louvre Mona Lisa may be a portrait of Costanza by Leonardo that had been thought lost.

  6. Point-of-Care Diagnostics in Low-Resource Settings and Their Impact on Care in the Age of the Noncommunicable and Chronic Disease Epidemic.

    Science.gov (United States)

    Weigl, Bernhard H; Neogi, Tina; McGuire, Helen

    2014-06-01

    The emergence of point-of-care (POC) diagnostics specifically designed for low-resource settings coupled with the rapid increase in need for routine care of patients with chronic diseases should prompt reconsideration of how health care can be delivered most beneficially and cost-effectively in developing countries. Bolstering support for primary care to provide rapid and appropriate integrated acute and chronic care treatment may be a possible solution. POC diagnostics can empower local and primary care providers and enable them to make better clinical decisions. This article explores the opportunity for POC diagnostics to strengthen primary care and chronic disease diagnosis and management in a low-resource setting (LRS) to deliver appropriate, consistent, and integrated care. We analyze the requirements of resource-appropriate chronic disease care, the characteristics of POC diagnostics in LRS versus the developed world, the many roles of diagnostics in the care continuum in LRS, and the process and economics of developing LRS-compatible POC diagnostics.

  7. Do Smallholder, Mixed Crop-Livestock Livelihoods Encourage Sustainable Agricultural Practices? A Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Thomas K. Rudel

    2016-02-01

    Full Text Available As calls for bolstering ecosystem services from croplands have grown more insistent during the past two decades, the search for ways to foster these agriculture-sustaining services has become more urgent. In this context we examine by means of a meta-analysis the argument, proposed by Robert McC. Netting, that small-scale, mixed crop-livestock farming, a common livelihood among poor rural peoples, leads to environmentally sustainable agricultural practices. As predicted, mixed crop-livestock farms exhibit more sustainable practices, but, contrary to predictions, a small scale of operation does not predict sustainability. Many smallholders on mixed crop-livestock farms use sustainable practices, but other smallholders practice a degrading, input-scarce agriculture. Some large farm operators use soil-conserving, minimum-tillage techniques while other large operators ignore soil-conserving techniques and practice an industrialized, high chemical input agriculture. The strength and pervasiveness of the link in the data between mixed crop-livestock farming and sustainable agricultural practices argues for agricultural policies that promote mixed crop-livestock livelihoods.

  8. Inner Structure of Starless Core L694--2 Derived from Millimeter-Wave Interferometry

    CERN Document Server

    Harvey, D W A; Myers, P C; Tafalla, M; Harvey, Daniel W.A.; Wilner, David J.; Myers, Philip C.; Tafalla, Mario

    2003-01-01

    We study the density structure of candidate contracting starless core L694-2 using 1.3 mm dust continuum observations from the IRAM Plateau de Bure Interferometer and the Berkeley-Illinois-Maryland Array, probing spatial scales from 10000-500 AU. The long baseline PdBI observations detect no emission, and limit the contamination from a compact component F_c < 2.7 mJy. This limit corresponds to a very small disk mass, M_disk < 5e-4 M_sun x (60 K / T_disk), and bolsters the ``starless'' interpretation of the core. The shorter baseline BIMA data are compared to density models using a physically motivated temperature distribution with a central minimum. This analysis provides clear evidence for a turn-over from the steep outer density profile observed in dust extinction to much more shallow behavior in the inner regions (<7500 AU). The best fit Bonnor-Ebert, Plummer-like, broken power law, and end-on cylinder models produce very similar flattened profiles and cannot be distinguished. We quantify the sens...

  9. Neuromorphic atomic switch networks.

    Directory of Open Access Journals (Sweden)

    Audrius V Avizienis

    Full Text Available Efforts to emulate the formidable information processing capabilities of the brain through neuromorphic engineering have been bolstered by recent progress in the fabrication of nonlinear, nanoscale circuit elements that exhibit synapse-like operational characteristics. However, conventional fabrication techniques are unable to efficiently generate structures with the highly complex interconnectivity found in biological neuronal networks. Here we demonstrate the physical realization of a self-assembled neuromorphic device which implements basic concepts of systems neuroscience through a hardware-based platform comprised of over a billion interconnected atomic-switch inorganic synapses embedded in a complex network of silver nanowires. Observations of network activation and passive harmonic generation demonstrate a collective response to input stimulus in agreement with recent theoretical predictions. Further, emergent behaviors unique to the complex network of atomic switches and akin to brain function are observed, namely spatially distributed memory, recurrent dynamics and the activation of feedforward subnetworks. These devices display the functional characteristics required for implementing unconventional, biologically and neurally inspired computational methodologies in a synthetic experimental system.

  10. Gravitational anomalies and one dimensional behaviour of black holes

    CERN Document Server

    Majhi, Bibhas Ranjan

    2015-01-01

    It has been pointed out by Bekenstein and Mayo that the behavior of the Black hole's entropy or information flow is similar to that through one-dimensional channel. Here I analyse the same issue with the use of gravitational anomalies. The rate of the entropy change ($\\dot{S}$) and the power ($P$) of the Hawking emission are calculated from the relevant components of the anomalous stress-tensor under the Unruh vacuum condition. I show that the dependence of $\\dot{S}$ on power is $\\dot{S}\\propto P^{1/2}$ which is identical to that for the information flow in one dimensional system. This is established by using the ($1+1$) dimensional gravitational anomalies first. Then the fact is further bolstered by considering the ($1+3$) dimensional gravitational anomalies. It is found that in the former case, the proportionality constant is exactly identical to one dimensional situation, known as Pendry's formula, while in later situation its value decreases.

  11. Smart Growth and the Challenge of Nimby: Multifamily Dwellings and their Association with Single-Family House Selling Prices in Tallahasse, Florida, USA

    Directory of Open Access Journals (Sweden)

    Huston GIBSON

    2013-06-01

    Full Text Available Citizens protest development when they consider it undesirable. One type of development commonly perceived as undesirable by single-family home owners is proximate multifamily housing, often considered a cause of property devaluation. This study assesses multifamily housing, by typology, and its monetary association with proximate single-family housing prices. The research design is a cross-sectional study using multivariate regression. The unit of analysis is the detached single-family dwelling. The study population is a sample taken from all arms-length owner-occupied, primary residence, detached single-family property transactions recorded in Tallahassee-Leon County, Florida, USA, during 2008. The key findings show no statistically significant negative associations between multifamily housing and single-family property selling prices in the sample; in fact, the two were positively correlated. These findings address single-family homeowner concerns about proximate multifamily housing and should bolster the political feasibility of Smart Growth policy, which recommends denser urban infill.

  12. Men as Allies Against Sexism

    Directory of Open Access Journals (Sweden)

    Sezgin Cihangir

    2014-06-01

    Full Text Available Sexism is often expressed in subtle and ambiguous ways, causing targets to doubt their own capabilities or to show stereotype-confirming behavior. This research examines whether the self-confidence and stereotype (dis-confirming behavior of targets of sexism can be bolstered when other male versus female sources suggest that sexism may have played a role. Both Study 1 (N = 78 and Study 2 (N = 90 show that a suggestion of sexism has more beneficial effects when it is made by male sources than when it is made by female sources. When males suggested that sexism had taken place, targets reported more self-confidence (less self-handicapping and higher personal performance state self-esteem and showed less stereotype confirmation (less self-stereotyping and better task performance than when sexism was suggested by a female source. Study 2 additionally revealed that targets are more likely to file a complaint when men suggest that sexism took place than when this same suggestion was made by women. These results indicate that men can constitute important allies against sexism if they speak out when sexist treatment takes place.

  13. The Alliance Negotiation Scale: A psychometric investigation.

    Science.gov (United States)

    Doran, Jennifer M; Safran, Jeremy D; Muran, J Christopher

    2016-08-01

    This study investigates the utility and psychometric properties of a new measure of psychotherapy process, the Alliance Negotiation Scale (ANS; Doran, Safran, Waizmann, Bolger, & Muran, 2012). The ANS was designed to operationalize the theoretical construct of negotiation (Safran & Muran, 2000), and to extend our current understanding of the working alliance concept (Bordin, 1979). The ANS was also intended to improve upon existing measures such as the Working Alliance Inventory (WAI; Horvath & Greenberg, 1986, 1989) and its short form (WAI-S; Tracey & Kokotovic, 1989) by expanding the emphasis on negative therapy process. The present study investigates the psychometric validity of the ANS test scores and interpretation-including confirming its original factor structure and evaluating its internal consistency and construct validity. Construct validity was examined through the ANS' convergence and divergence with several existing scales that measure theoretically related constructs. The results bolster and extend previous findings about the psychometric integrity of the ANS, and begin to illuminate the relationship between negotiation and other important variables in psychotherapy research. (PsycINFO Database Record

  14. Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.

    Science.gov (United States)

    Jiang, T T; Chaturvedi, V; Ertelt, J M; Xin, L; Clark, D R; Kinder, J M; Way, S S

    2015-07-01

    Commensal enteric bacteria maintain systemic immune responsiveness that protects against disseminated or localized infection in extra-intestinal tissues caused by pathogenic microbes. However, as shifts in infection susceptibility after commensal bacteria eradication have primarily been probed using viruses, the broader applicability to other pathogen types remains undefined. In sharp contrast to diminished antiviral immunity, we show commensal bacteria eradication bolsters protection against disseminated Candida albicans fungal infection. Enhanced antifungal immunity reflects more robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, and their mobilization into infected tissues among antibiotic-treated compared with commensal bacteria-replete control mice. Reciprocally, depletion of neutrophils from expanded levels or intestinal lipopolysaccharide reconstitution overrides the antifungal protective benefits conferred by commensal bacteria eradication. This discordance in antifungal compared with antiviral immunity highlights intrinsic differences in how commensal bacteria control responsiveness for specific immune cell subsets, because pathogen-specific CD8(+) T cells that protect against viruses were suppressed similarly after C. albicans and influenza A virus infection. Thus, positive calibration of antiviral immunity by commensal bacteria is counterbalanced by restrained activation of other immune components that confer antifungal immunity.

  15. The potential of crowdsourcing and mobile technology to support flood disaster risk reduction

    Science.gov (United States)

    See, Linda; McCallum, Ian; Liu, Wei; Mechler, Reinhard; Keating, Adriana; Hochrainer-Stigler, Stefan; Mochizuki, Junko; Fritz, Steffen; Dugar, Sumit; Arestegui, Michael; Szoenyi, Michael; Laso-Bayas, Juan-Carlos; Burek, Peter; French, Adam; Moorthy, Inian

    2016-04-01

    The last decade has seen a rise in citizen science and crowdsourcing for carrying out a variety of tasks across a number of different fields, most notably the collection of data such as the identification of species (e.g. eBird and iNaturalist) and the classification of images (e.g. Galaxy Zoo and Geo-Wiki). Combining human computing with the proliferation of mobile technology has resulted in vast amounts of geo-located data that have considerable value across multiple domains including flood disaster risk reduction. Crowdsourcing technologies, in the form of online mapping, are now being utilized to great effect in post-disaster mapping and relief efforts, e.g. the activities of Humanitarian OpenStreetMap, complementing official channels of relief (e.g. Haiti, Nepal and New York). Disaster event monitoring efforts have been further complemented with the use of social media (e.g. twitter for earthquakes, flood monitoring, and fire detection). Much of the activity in this area has focused on ex-post emergency management while there is considerable potential for utilizing crowdsourcing and mobile technology for vulnerability assessment, early warning and to bolster resilience to flood events. This paper examines the use of crowdsourcing and mobile technology for measuring and monitoring flood hazards, exposure to floods, and vulnerability, drawing upon examples from the literature and ongoing projects on flooding and food security at IIASA.

  16. MEDICAL BRIGADES, GLOBAL HEALTH AND THE UNITED NATIONS: MILLENNIUM DEVELOPMENT GOALS AND DEVELOPING NATIONS.

    Science.gov (United States)

    Portman, Mark T; Martin, Edward J

    2015-01-01

    Recently, recommendations have been made that global health initiatives change their focus from disease specific intervention to bolstering health systems and general health care. The aim of this is to ultimately increase access to primary care, clean water, education, hygiene, and prevent malnutrition, among other goals. While many major global health initiatives have followed this trend, so have many smaller scale programs including short-term medical brigades. Despite a trending increase in the number of privately run short-term medical brigades, until recently, little research has been done on the potential positive and negative effects that can arise from such programs. Now, guidelines have been initiated to create well-structured programs. When followed, these smaller scale initiatives can be successful in helping increase access to healthcare, sustainably strengthening communities in terms of general health. While recent legislation in the United States has addressed domestic policy in the Patient Protection Affordable Care Act of 2010 (ACA), the ACA should also consider some of the basic "sustainable" policies being implemented by international health care providers.

  17. Learning from Pulsating Stars: Progress over the Last Century (Abstract)

    Science.gov (United States)

    Smith, H.

    2016-12-01

    (Abstract only) Scarcely more than a century has elapsed since it began to be widely accepted that pulsation plays an important role in the variability of stars. During that century pulsating stars have been used as tools to explore a variety of astrophysical questions, including the determination of distances to other galaxies, the testing of timescales of evolution through the HR diagram, and the identification of the ages and star formation histories of stellar populations. Among the significant early milestones along this investigative path are Henrietta Leavitt's discovery of a relation between the periods and luminosities of Cepheids, Harlow Shapley's proposal that all Cepheids are pulsating stars, and Arthur Stanley Eddington's use of the observed period change of d Cephei to constrain its power source. Today our explorations of pulsating stars are bolstered by long observational histories of brighter variables, surveys involving unprecedentedly large numbers of stars, and improved theoretical analyses. This talk will review aspects of the history and our current understanding of pulsating stars, paying particular attention to RR Lyrae, d Scuti, and Cepheid variables. Observations by AAVSO members have provided insight into several questions regarding the behavior of these stars.

  18. Biofidelity Evaluation of a Prototype Hybrid III 6 Year-Old ATD Lower Extremity.

    Science.gov (United States)

    Boucher, Laura C; Bing, Julie; Bolte, John H

    2016-09-01

    Incomplete instrumentation and a lack of biofidelity in the extremities of the 6 year-old anthropomorphic test device (ATD) pose challenges when studying regions of the body known to interact with the vehicle interior. This study sought to compare a prototype Hybrid III 6 year-old ATD leg (ATD-LE), with a more biofidelic ankle and tibia load cell, to previously collected child volunteer data and to the current Hybrid III 6 year-old ATD (HIII). Anthropometry, range of motion (ROM), and stiffness measurements were taken, along with a dynamic evaluation of the ATD-LE using knee-bolster airbag (KBA) test scenarios. Anthropometry values were similar in eight of twelve measurements. Total ankle ROM was improved in the ATD-LE with no bumper compared to the HIII. The highest tibia moments and tibia index values were recorded in KBA scenarios when the toes were positioned in contact with the dashboard prior to airbag deployment, forcing the ankle into axial loading and dorsiflexion. While improvements in the biofidelity of the ATD-LE are still necessary, the results of this study are encouraging. Continued advancement of the 6 year-old ATD ankle is necessary to provide a tool to directly study the behavior of the leg during a motor vehicle crash.

  19. Science Alive!: Connecting with Elementary Students through Science Exploration

    Directory of Open Access Journals (Sweden)

    Aarti Raja

    2016-05-01

    Full Text Available A novel program called Science Alive! was developed by undergraduate faculty members, K–12 school teachers, and undergraduate students to enrich science, technology, engineering, and mathematics (STEM literacy at community schools located near the university. The ultimate goal of the program is to bolster the scientific knowledge and appreciation of local area students and community members and serve as a model for similar programs. Through the program, we observed that elementary school students made gains toward learning their grade-level science curricula after a hands-on learning experience and had fun doing these hands-on activities. Through the program, undergraduate students, working with graduate students and alumni, build scientific learning modules using explanatory handouts and creative activities as classroom exercises. This helps better integrate scientific education through a collaborative, hands-on learning program. Results showed that elementary school students made the highest learning gains in their performance on higher-level questions related to both forces and matter as a result of the hands-on learning modules. Additionally, college students enjoyed the hands-on activities, would consider volunteering their time at such future events, and saw the service learning program as a benefit to their professional development through community building and discipline-specific service. The science modules were developed according to grade-level curricular standards and can be used year after year to teach or explain a scientific topic to elementary school students via a hands-on learning approach.

  20. Regulatory and institutional developments in the Ontario wine and grape industry

    Directory of Open Access Journals (Sweden)

    Carew R

    2012-09-01

    Full Text Available Richard Carew,1 Wojciech J Florkowski21Agriculture and Agri-Food Canada, Pacific Agri-Food Research Centre, Summerland, BC, Canada; 2Department of Agricultural and Applied Economics, University of Georgia, Griffin, GA, USAAbstract: The Ontario wine industry has undergone major transformative changes over the last two decades. These have corresponded to the implementation period of the Ontario Vintners Quality Alliance (VQA Act in 1999 and the launch of the Winery Strategic Plan, "Poised for Greatness," in 2002. While the Ontario wine regions have gained significant recognition in the production of premium quality wines, the industry is still dominated by a few large wine companies that produce the bulk of blended or "International Canadian Blends" (ICB, and multiple small/mid-sized firms that produce principally VQA wines. This paper analyzes how winery regulations, industry changes, institutions, and innovation have impacted the domestic production, consumption, and international trade, of premium quality wines. The results of the study highlight the regional economic impact of the wine industry in the Niagara region, the success of small/mid-sized boutique wineries producing premium quality wines for the domestic market, and the physical challenges required to improve domestic VQA wine retail distribution and bolster the international trade of wine exports. Domestic success has been attributed to the combination of natural endowments, entrepreneurial talent, established quality standards, and the adoption of improved viticulture practices.Keywords: Ontario, wine, quality standards

  1. Reappraisal of nuclear quadrupole moments of atomic halogens via relativistic coupled cluster linear response theory for the ionization process.

    Science.gov (United States)

    Chaudhuri, Rajat K; Chattopadhyay, Sudip; Mahapatra, Uttam Sinha

    2013-11-27

    The coupled cluster based linear response theory (CCLRT) with four-component relativistic spinors is employed to compute the electric field gradients (EFG) of (35)Cl, (79)Br, and (127)I nuclei. The EFGs resulting from these calculations are combined with experimental nuclear quadrupole coupling constants (NQCC) to determine the nuclear quadrupole moments (NQM), Q of the halide nuclei. Our estimated NQMs [(35)Cl = -81.12 mb, (79)Br = 307.98 mb, and (127)I = -688.22 mb] agree well with the new atomic values [(35)Cl = -81.1(1.2), (79)Br = 302(5), and (127)I = -680(10) mb] obtained via Fock space multireference coupled cluster method with the Dirac-Coulomb-Breit Hamiltonian. Although our estimated Q((79)Br) value deviates from the accepted reference value of 313(3) mb, it agrees well with the recently recommended value, Q((79)Br) = 308.7(20) mb. Good agreement with current reference data indicates the accuracy of the proposed value for these halogen nuclei and lends credence to the results obtained via CCLRT approach. The electron affinities yielded by this method with no extra cost are also in good agreement with experimental values, which bolster our belief that the NQMs values for halogen nuclei derived here are reliable.

  2. Spectroscopy of Young Planetary Mass Candidates with Disks

    CERN Document Server

    Jayawardhana, R; Jayawardhana, Ray; Ivanov, Valentin D.

    2006-01-01

    It is now well established that many young brown dwarfs exhibit characteristics similar to classical T Tauri stars, including infrared excess from disks and emission lines related to accretion. Whether the same holds true for even lower mass objects, namely those near and below the Deuterium-burning limit, is an important question. Here we present optical spectra of six isolated planetary mass candidates in Chamaeleon II, Lupus I and Ophiuchus star-forming regions, recently identified by Allers and collaborators to harbor substantial mid-infrared excesses. Our spectra, from ESO's Very Large Telescope and New Technology Telescope, show that four of the targets have spectral types in the ~M9-L1 range, and three of those also exhibit H_alpha. Their luminosities are consistent with masses of ~5-15 M_{Jupiter} according to models of Chabrier, Baraffe and co-workers, thus placing these four objects among the lowest mass brown dwarfs known to be surrounded by circum-sub-stellar disks. Our findings bolster the idea t...

  3. Precision measures of the primordial abundance of deuterium

    CERN Document Server

    Cooke, Ryan; Jorgenson, Regina A; Murphy, Michael T; Steidel, Charles C

    2013-01-01

    We report the discovery of deuterium absorption in the very metal-poor ([Fe/H] = -2.87) damped Lyman-alpha system at z_abs = 3.06726 towards the QSO SDSS J1358+6522. On the basis of 13 resolved D I absorption lines and the damping wings of the H I Lyman alpha transition, we have obtained a new, precise measure of the primordial abundance of deuterium. Furthermore, to bolster the present statistics of precision D/H measures, we have reanalyzed all of the known deuterium absorption-line systems that satisfy a set of strict criteria. We have adopted a blind analysis strategy (to remove human bias), and developed a software package that is specifically designed for precision D/H abundance measurements. For this reanalyzed sample of systems, we obtain a weighted mean of (D/H)_p = (2.53 +/- 0.04) x 10^-5, corresponding to a Universal baryon density 100 Omega_b h^2 = 2.202 +/- 0.045 for the standard model of Big Bang Nucleosynthesis. By combining our measure of (D/H)_p with observations of the cosmic microwave backg...

  4. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Le Saux, Claude Jourdan; Davy, Philip; Brampton, Christopher; Ahuja, Seema S; Fauce, Steven; Shivshankar, Pooja; Nguyen, Hieu; Ramaseshan, Mahesh; Tressler, Robert; Pirot, Zhu; Harley, Calvin B; Allsopp, Richard

    2013-01-01

    The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a novel mouse model, we tested the potential of GRN510 to limit fibrosis induced by bleomycin in mTERT heterozygous mice. Treatment with GRN510 at 10 mg/kg/day activated telomerase 2-4 fold both in hematopoietic progenitors ex vivo and in bone marrow and lung tissue in vivo, respectively. Telomerase activation was countered by co-treatment with Imetelstat (GRN163L), a potent telomerase inhibitor. In this model of bleomycin-induced fibrosis, treatment with GRN510 suppressed the development of fibrosis and accumulation of senescent cells in the lung via a mechanism dependent upon telomerase activation. Treatment of small airway epithelial cells (SAEC) or lung fibroblasts ex vivo with GRN510 revealed telomerase activating and replicative lifespan promoting effects only in the SAEC, suggesting that the mechanism accounting for the protective effects of GRN510 against induced lung fibrosis involves specific types of lung cells. Together, these results support the use of small molecule activators of telomerase in therapies to treat idiopathic pulmonary fibrosis.

  5. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

    Directory of Open Access Journals (Sweden)

    Claude Jourdan Le Saux

    Full Text Available The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo and in vivo. Using a novel mouse model, we tested the potential of GRN510 to limit fibrosis induced by bleomycin in mTERT heterozygous mice. Treatment with GRN510 at 10 mg/kg/day activated telomerase 2-4 fold both in hematopoietic progenitors ex vivo and in bone marrow and lung tissue in vivo, respectively. Telomerase activation was countered by co-treatment with Imetelstat (GRN163L, a potent telomerase inhibitor. In this model of bleomycin-induced fibrosis, treatment with GRN510 suppressed the development of fibrosis and accumulation of senescent cells in the lung via a mechanism dependent upon telomerase activation. Treatment of small airway epithelial cells (SAEC or lung fibroblasts ex vivo with GRN510 revealed telomerase activating and replicative lifespan promoting effects only in the SAEC, suggesting that the mechanism accounting for the protective effects of GRN510 against induced lung fibrosis involves specific types of lung cells. Together, these results support the use of small molecule activators of telomerase in therapies to treat idiopathic pulmonary fibrosis.

  6. Two highly similar LAEDDTNAQKT and LTDKIGTEI epitopes in G glycoprotein may be useful for effective epitope based vaccine design against pathogenic Henipavirus.

    Science.gov (United States)

    Parvege, Md Masud; Rahman, Monzilur; Nibir, Yead Morshed; Hossain, Mohammad Shahnoor

    2016-04-01

    Nipah virus and Hendra virus, two members of the genus Henipavirus, are newly emerging zoonotic pathogens which cause acute respiratory illness and severe encephalitis in human. Lack of the effective antiviral therapy endorses the urgency for the development of vaccine against these deadly viruses. In this study, we employed various computational approaches to identify epitopes which has the potential for vaccine development. By analyzing the immune parameters of the conserved sequences of G glycoprotein using various databases and bioinformatics tools, we identified two potential epitopes which may be used as peptide vaccines. Using different B cell epitope prediction servers, four highly similar B cell epitopes were identified. Immunoinformatics analyses revealed that LAEDDTNAQKT is a highly flexible and accessible B-cell epitope to antibody. Highly similar putative CTL epitopes were analyzed for their binding with the HLA-C 12*03 molecule. Docking simulation assay revealed that LTDKIGTEI has significantly lower binding energy, which bolstered its potential as epitope-based vaccine design. Finally, cytotoxicity analysis has also justified their potential as promising epitope-based vaccine candidate. In sum, our computational analysis indicates that either LAEDDTNAQKT or LTDKIGTEI epitope holds a promise for the development of universal vaccine against all kinds of pathogenic Henipavirus. Further in vivo and in vitro studies are necessary to validate the obtained findings.

  7. Biogas energy from family-sized digesters in Uganda. Critical factors and policy implications

    Energy Technology Data Exchange (ETDEWEB)

    Walekhwa, Peter N.; Mugisha, Johnny [Department of Agricultural Economics and Agribusiness, Makerere University, P.O. Box 7062, Kampala (Uganda); Drake, Lars [Swedish Chemicals Agency, P.O. Box 2, SE-172 13, Sundbyberg (Sweden)

    2009-07-15

    Dependence on fossil energy sources is increasingly becoming unsustainable due to ecological and environmental problems and rapid depletion. Biogas energy could augment these conventional energy sources but despite its advantages and favourable conditions for its production, biogas energy use in Uganda remains low due to technical, economic and socio-cultural impediments. Based on primary data on households in Central and Eastern Uganda and the use of logistic regression, this study analyses factors affecting the adoption of biogas energy in Uganda. The empirical results suggest that the probability of a household adopting biogas technology increases with decreasing age of head of household, increasing household income, increasing number of cattle owned, increasing household size, male head of household and increasing cost of traditional fuels. In contrast, the likelihood of adoption decreases with increasing remoteness of household location and increasing household land area. Policy options and recommendations including educational and awareness campaigns on biogas benefits and successes, the provision of financial and non-financial incentives to households and establishment of an institutional framework could bolster wider biogas energy acceptance in Uganda. (author)

  8. Biogas energy from family-sized digesters in Uganda: Critical factors and policy implications

    Energy Technology Data Exchange (ETDEWEB)

    Walekhwa, Peter N. [Department of Agricultural Economics and Agribusiness, Makerere University, P.O. Box 7062, Kampala (Uganda)], E-mail: Peter.Walekhwa@mv.slu.se; Mugisha, Johnny [Department of Agricultural Economics and Agribusiness, Makerere University, P.O. Box 7062, Kampala (Uganda); Drake, Lars [Swedish Chemicals Agency, P.O. Box 2, SE-172 13, Sundbyberg (Sweden)

    2009-07-15

    Dependence on fossil energy sources is increasingly becoming unsustainable due to ecological and environmental problems and rapid depletion. Biogas energy could augment these conventional energy sources but despite its advantages and favourable conditions for its production, biogas energy use in Uganda remains low due to technical, economic and socio-cultural impediments. Based on primary data on households in Central and Eastern Uganda and the use of logistic regression, this study analyses factors affecting the adoption of biogas energy in Uganda. The empirical results suggest that the probability of a household adopting biogas technology increases with decreasing age of head of household, increasing household income, increasing number of cattle owned, increasing household size, male head of household and increasing cost of traditional fuels. In contrast, the likelihood of adoption decreases with increasing remoteness of household location and increasing household land area. Policy options and recommendations including educational and awareness campaigns on biogas benefits and successes, the provision of financial and non-financial incentives to households and establishment of an institutional framework could bolster wider biogas energy acceptance in Uganda.

  9. Peripheral Visual Cues: Their Fate in Processing and Effects on Attention and Temporal-Order Perception

    Science.gov (United States)

    Tünnermann, Jan; Scharlau, Ingrid

    2016-01-01

    Peripheral visual cues lead to large shifts in psychometric distributions of temporal-order judgments. In one view, such shifts are attributed to attention speeding up processing of the cued stimulus, so-called prior entry. However, sometimes these shifts are so large that it is unlikely that they are caused by attention alone. Here we tested the prevalent alternative explanation that the cue is sometimes confused with the target on a perceptual level, bolstering the shift of the psychometric function. We applied a novel model of cued temporal-order judgments, derived from Bundesen's Theory of Visual Attention. We found that cue–target confusions indeed contribute to shifting psychometric functions. However, cue-induced changes in the processing rates of the target stimuli play an important role, too. At smaller cueing intervals, the cue increased the processing speed of the target. At larger intervals, inhibition of return was predominant. Earlier studies of cued TOJs were insensitive to these effects because in psychometric distributions they are concealed by the conjoint effects of cue–target confusions and processing rate changes.

  10. Golden Jubilee Photos: Four giants break new ground

    CERN Multimedia

    2004-01-01

    The four LHC experiments are on an unprecedented scale. The detectors will record particle collisions far more powerful than those at any other particle accelerator. One of the detectors, ATLAS, will be the largest-volume particle detector ever, a cylinder 45 metres long and 25 metres high. And the collaborations are a step beyond LHC's predecessor, LEP, involving even more people from more countries. Together, these four experiments promise to open a door to new realms of physics. CMS and ATLAS are both general-purpose detectors, whose major quarry include the Higgs particle, which could give other particles their mass, and supersymmetric particles, which would bolster theories beyond the Standard Model. A major technical challenge for CMS has been acquiring 61 000 large, precision-grown crystals, denser than iron, for catching high-energy photons and electrons (1st bottom photo). ATLAS includes the world's largest superconducting magnets (2nd bottom photo), eight coils arranged into a large barrel shape t...

  11. A New Spin on Photoemission Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Jozwiak, Chris [Univ. of California, Berkeley, CA (United States)

    2008-12-01

    The electronic spin degree of freedom is of general fundamental importance to all matter. Understanding its complex roles and behavior in the solid state, particularly in highly correlated and magnetic materials, has grown increasingly desirable as technology demands advanced devices and materials based on ever stricter comprehension and control of the electron spin. However, direct and efficient spin dependent probes of electronic structure are currently lacking. Angle Resolved Photoemission Spectroscopy (ARPES) has become one of the most successful experimental tools for elucidating solid state electronic structures, bolstered by-continual breakthroughs in efficient instrumentation. In contrast, spin-resolved photoemission spectroscopy has lagged behind due to a lack of similar instrumental advances. The power of photoemission spectroscopy and the pertinence of electronic spin in the current research climate combine to make breakthroughs in Spin and Angle Resolved Photoemission Spectroscopy (SARPES) a high priority . This thesis details the development of a unique instrument for efficient SARPES and represents a radical departure from conventional methods. A custom designed spin polarimeter based on low energy exchange scattering is developed, with projected efficiency gains of two orders of magnitude over current state-of-the-art polarimeters. For energy analysis, the popular hemispherical analyzer is eschewed for a custom Time-of-Flight (TOF) analyzer offering an additional order of magnitude gain in efficiency. The combined instrument signifies the breakthrough needed to perform the high resolution SARPES experiments necessary for untangling the complex spin-dependent electronic structures central to today's condensed matter physics.

  12. Beyond traditional scientific training: The importance of community and empowerment for women in ecology and evolutionary biology

    Directory of Open Access Journals (Sweden)

    M. Claire Horner-Devine

    2016-10-01

    Full Text Available While the biological sciences have achieved gender parity in the undergraduate and graduate career stages, this is not the case at the faculty level. The WEBS (Women Evolving the Biological Sciences symposia go beyond traditional scientific training and professional development to address factors critical to women’s persistence in faculty careers: community and empowerment. Through a series of panel discussions, personal reflections and skills workshops, WEBS creates a community-based professional development experience and a space for participants to grapple with central issues affecting their scientific careers. Longitudinal qualitative survey data suggest that WEBS bolsters the participants’ confidence and empowerment, in addition to providing concrete skills for addressing a range of issues necessary to navigating scientific careers, leading to increased career satisfaction and career self-efficacy (i.e., the belief in one’s capacity to pursue their chosen career. These results highlight the importance and need for programs and opportunities for women in STEM that go beyond training in scientific skills and traditional professional development to include those that create a sense of community and empowerment.

  13. Career Choice and Longevity in U.S. Psychiatric-Mental Health Nurses.

    Science.gov (United States)

    Alexander, Robbi K; Diefenbeck, Cynthia A; Brown, Carlton G

    2015-06-01

    The demand for mental health services in the United States taxes the existing care continuum and is projected to increase as federal initiatives such as the Affordable Care Act and mental health parity improve access to, and coverage for, mental health services. Quality health care providers, such as psychiatric-mental health nurses, are needed to bolster the mental health system. Prior research has focused on the unpopularity of psychiatric nursing as a career choice for nursing students. The purpose of this study is to understand how seasoned psychiatric nurses came to choose and remain in the specialty; descriptive phenomenology is used. In a face-to-face interview, eight registered nurses described their experiences with psychiatric nursing as a student, their entry into psychiatric nursing, and factors related to their longevity in the specialty. Giorgi's Existential Phenomenological Research Method was employed to analyze the interview data. Three themes emerged related to career choice: Interest Developed Prior to or While in Nursing School, Personal Relevance, and Validation of Potential. Three themes emerged related to retention: Overcoming Stereotypes to Develop Career Pride, Positive Team Dynamics, and Remaining Hopeful. Nurse educators play an important role in identifying talent, validating capability, enhancing interest, and increasing students' confidence to pursue a psychiatric nursing career, while nursing administrators and clinical specialists play a key role in retention. Findings also stimulate pertinent questions surrounding the long-term viability of the psychiatric-mental health nursing specialty.

  14. Random subspaces in quantum information theory

    Science.gov (United States)

    Hayden, Patrick

    2005-03-01

    The selection of random unitary transformations plays a role in quantum information theory analogous to the role of random hash functions in classical information theory. Recent applications have included protocols achieving the quantum channel capacity and methods for extending superdense coding from bits to qubits. In addition, the corresponding random subspaces have proved useful for studying the structure of bipartite and multipartite entanglement. In quantum information theory, we're fond of saying that Hilbert space is a big place, the implication being that there's room for the unexpected to occur. The goal of this talk is to further bolster this homespun wisdowm. I'm going to present a number of results in quantum information theory that stem from the initially counterintuitive geometry of high-dimensional vector spaces, where subspaces with highly extremal properties are the norm rather than the exception. Peter Shor has shown, for example, that randomly selected subspaces can be used to send quantum information through a noisy quantum channel at the highest possible rate, that is, the quantum channel capacity. More recently, Debbie Leung, Andreas Winter and I demonstrated that a randomly chosen subspace of a bipartite quantum system will likely contain nothing but nearly maximally entangled states, even if the subspace is nearly as large as the original system in qubit terms. This observation has implications for communication, especially superdense coding.

  15. Adapting to change in healthcare: aligning strategic intent and operational capacity.

    Science.gov (United States)

    Ford, Randal; Boss, R Wayne; Angermeier, Ingo; Townson, Charles D; Jennings, Thomas A

    2004-01-01

    The concept of a stakeholder is commonplace in a business context. Participative- democratic communication refers to those organization-wide principles and practices that "represent" many relevant stakeholders in the decision making of work-related activities. One case in point is as follows: In May 2000, the Spartanburg Regional Healthcare System board of directors forced its CEO to resign, ending his 6-year tenure and the heated controversy of the previous 2 months. The former CEO focused primarily on strategic growth to the detriment of operations. Through participative-democratic practices, the interim CEO mended the damaged relations between the hospital administration, the community, and employee stakeholders in surfacing conflict to bolster operational efficiency. The current CEO attended to building stakeholder relationships and trust as a way to wed strategic growth and the organization's capacity to maintain it. Top executive managers and directly involved community political leaders helped in developing the participative-democratic communication principles set forth in this article. These core principles are (a) creating the space for new communicative interaction, (b) safeguarding a credible and open process, and (c) reclaiming suppressed views.

  16. Imaging electrostatically confined Dirac fermions in graphene quantum dots

    Science.gov (United States)

    Lee, Juwon; Wong, Dillon; Velasco, Jairo, Jr.; Rodriguez-Nieva, Joaquin F.; Kahn, Salman; Tsai, Hsin-Zon; Taniguchi, Takashi; Watanabe, Kenji; Zettl, Alex; Wang, Feng; Levitov, Leonid S.; Crommie, Michael F.

    2016-11-01

    Electrostatic confinement of charge carriers in graphene is governed by Klein tunnelling, a relativistic quantum process in which particle-hole transmutation leads to unusual anisotropic transmission at p-n junction boundaries. Reflection and transmission at these boundaries affect the quantum interference of electronic waves, enabling the formation of novel quasi-bound states. Here we report the use of scanning tunnelling microscopy to map the electronic structure of Dirac fermions confined in quantum dots defined by circular graphene p-n junctions. The quantum dots were fabricated using a technique involving local manipulation of defect charge within the insulating substrate beneath a graphene monolayer. Inside such graphene quantum dots we observe resonances due to quasi-bound states and directly visualize the quantum interference patterns arising from these states. Outside the quantum dots Dirac fermions exhibit Friedel oscillation-like behaviour. Bolstered by a theoretical model describing relativistic particles in a harmonic oscillator potential, our findings yield insights into the spatial behaviour of electrostatically confined Dirac fermions.

  17. Inside the whale: the structure and dynamics of the isolated Cetus dwarf spheroidal

    CERN Document Server

    Lewis, G F; Chapman, S C; McConnachie, A; Irwin, M J; Tolstoy, E; Tanvir, N R

    2006-01-01

    This paper presents a study of the Cetus dwarf, an isolated dwarf galaxy within the Local Group. A matched-filter analysis of the INT/WFC imaging of this system reveals no evidence for significant tidal debris that could have been torn from the galaxy, bolstering the hypothesis that Cetus has never significantly interacted with either the Milky Way or M31. Additionally, Keck/Deimos spectroscopic observations identify this galaxy as a distinct kinematic population possessing a systematic velocity of $-87\\pm2{\\rm km\\ s^{-1}}$ and with a velocity dispersion of $17\\pm2{\\rm km s^{-1}}$; while tentative, these data also suggest that Cetus possesses a moderate rotational velocity of $\\sim8{\\rm km s^{-1}}$. The population is confirmed to be relatively metal-poor, consistent with ${\\rm [Fe/H]\\sim-1.9}$, and, assuming virial equilibrium, implies that the Cetus dwarf galaxy possesses a $M/L\\sim70$. It appears, therefore, that Cetus may represent a primordial dwarf galaxy, retaining the kinematic and structural propertie...

  18. Erich Regener and the maximum in ionisation of the atmosphere

    CERN Document Server

    Carlson, P

    2014-01-01

    In the 1930s the German physicist Erich Regener (1881-1955) did important work on the measurement of the rate of production of ionisation deep under-water and in the atmosphere. He discovered, along with one of his students, Georg Pfotzer, the altitude at which the production of ionisation in the atmosphere reaches a maximum, often, but misleadingly, called the Pfotzer maximum. Regener was one of the first to estimate the energy density of cosmic rays, an estimate that was used by Baade and Zwicky to bolster their postulate that supernovae might be their source. Yet Regener's name is less recognised by present-day cosmic ray physicists than it should be largely because in 1937 he was forced to take early retirement by the National Socialists as his wife had Jewish ancestors. In this paper we briefly review his work on cosmic rays and recommend an alternative naming of the ionisation maximum. The influence that Regener had on the field through his son, his son-in-law, his grandsons and his students and through...

  19. Exploratory study of the feasibility and utility of the colored eco-genetic relationship map (CEGRM) in women at high genetic risk of developing breast cancer.

    Science.gov (United States)

    Peters, June A; Kenen, Regina; Giusti, Ruthann; Loud, Jennifer; Weissman, Nancy; Greene, Mark H

    2004-10-15

    We report here the results of an exploratory feasibility study of the colored eco-genetic relationship map (CEGRM), a novel, recently-developed psychosocial assessment tool, which incorporates features of the genetic pedigree, family systems genogram, and ecomap. The CEGRM presents a simple, concise, visual representation of the social interaction domains of information, services, and emotional support through the application of color-coded symbols to the genetic pedigree. The interactive process of completing the CEGRM was designed to facilitate contemporary genetic counseling goals of: (a) understanding the client in the context of her/his social milieu; (b) bolstering client self-awareness and insight; (c) fostering active client participation and mutuality in the counseling interaction; (d) eliciting illuminating social narratives; and (e) addressing outstanding emotional issues. Twenty women participating in a breast imaging study of women from families with BRCA1/2 mutations completed and evaluated various aspects of the CEGRM. We found that efficient construction of the CEGRM was feasible, and that compliance was excellent. Participants developed insights into their social milieu through observing the visual pattern of relationships illustrated by the CEGRM. The process of co-constructing the CEGRM fostered the participant's active involvement in the session, marked by mutuality and increased empathy. In this clinical research context, the participants felt free to share poignant stories about their friends and families. Further studies are planned to refine the CEGRM and to examine its utility in cancer genetics research.

  20. Interventions to enhance the spiritual aspects of dying.

    Science.gov (United States)

    Chochinov, Harvey Max; Cann, Beverley J

    2005-01-01

    In recent years, medical and allied health publications have begun to address various topics on spirituality. Scholars have posited numerous definitions of spirituality and wrestled with the notion of spiritual pain and suffering. Researchers have examined the relationship between spirituality and health and explored, among other topics, patients' perceptions of their spiritual needs, particularly at the end of life. This paper summarizes salient evidence pertaining to spirituality, dying patients, their health care providers, and family or informal caregivers. We examine the challenging issue of how to define spirituality, and provide a brief overview of the state of evidence addressing interventions that may enhance or bolster spiritual aspects of dying. There are many pressing questions that need to be addressed within the context of spiritual issues and end-of-life care. Efforts to understand more fully the constructs of spiritual well-being, transcendence, hope, meaning, and dignity, and to correlate them with variables and outcomes such as quality of life, pain control, coping with loss, and acceptance are warranted. Researchers should also frame these issues from both faith-based and secular perspectives, differing professional viewpoints, and in diverse cultural settings. In addition, longitudinal studies will enable patients' changing experiences and needs to be assessed over time. Research addressing spiritual dimensions of personhood offers an opportunity to expand the horizons of contemporary palliative care, thereby decreasing suffering and enhancing the quality of time remaining to those who are nearing death.

  1. Problematic alcohol use among individuals with HIV: relations with everyday memory functioning and HIV symptom severity.

    Science.gov (United States)

    Heinz, Adrienne J; Fogler, Kethera A; Newcomb, Michael E; Trafton, Jodie A; Bonn-Miller, Marcel O

    2014-07-01

    Problematic alcohol use has been shown to negatively impact cognitive functions germane to achieving optimal HIV health outcomes. The present study, a secondary data analysis, examined the impact of problematic alcohol use on aspects of everyday memory functioning in a sample of 172 HIV-infected individuals (22 % female; Mage = 48.37 years, SD = 8.64; 39 % Black/non-Hispanic). Additionally, we tested whether self-reported memory functioning explained the relation between problematic alcohol use and HIV symptom severity. Results indicated that problematic patterns of alcohol use were associated with lower total memory functioning, retrieval (e.g., recall-difficulty) and memory for activity (e.g., what you did yesterday) and greater HIV symptom severity. Memory functioning mediated the relation between problematic alcohol use and HIV symptom severity. However, the direction of this relation was unclear as HIV symptom severity also mediated the relation between problematic alcohol use and memory functioning. Findings highlight the importance of integrated care for HIV and alcohol use disorders and suggest that routine alcohol and cognitive screenings may bolster health outcomes among this vulnerable population.

  2. Strategies and attributes of highly productive scholars and contributors to the school psychology literature: recommendations for increasing scholarly productivity.

    Science.gov (United States)

    Martínez, Rebecca S; Floyd, Randy G; Erichsen, Luke W

    2011-12-01

    In all academic fields, there are scholars who contribute to the research literature at exceptionally high levels. The goal of the current study was to discover what school psychology researchers with remarkably high levels of journal publication do to be so productive. In Study 1, 94 highly productive school psychology scholars were identified from past research, and 51 (39 men, 12 women) submitted individual, short-answer responses to a 5-item questionnaire regarding their research strategies. A constant comparative approach was employed to sort and code individual sentiments (N=479) into categories. Seven broad categories of counsel for increasing productivity emerged: (a) research and publication practices and strategies, (b) collaboration, mentoring and building relationships, (c) navigating the peer-review process, (d) strategies to bolster writing productivity and excellence, (e) personal character traits that foster productivity, (f) preparation before entering the professoriate, and (g) other noteworthy sentiments. Results are discussed in terms of nine recommendations for scholars and graduate students who wish to increase their productivity. In Study 2, five of the most productive scholars (1 woman, 4 men) participated in a semi-structured interview about their high levels of productivity. Interviews were recorded, transcribed, and analyzed, and a case analysis approach employed to profile each scholar. Study limitations and suggestions for future research are discussed.

  3. FIPSER: Performance study of a readout concept with few digitization levels for fast signals

    Science.gov (United States)

    Limyansky, B.; Reese, R.; Cressler, J. D.; Otte, A. N.; Taboada, I.; Ulusoy, C.

    2016-11-01

    We discuss the performance of a readout system, Fixed Pulse Shape Efficient Readout (FIPSER), to digitize signals from detectors with a fixed pulse shape. In this study we are mainly interested in the readout of fast photon detectors like photomultipliers or Silicon photomultipliers. But the concept can be equally applied to the digitization of other detector signals. FIPSER is based on the flash analog to digital converter (FADC) concept, but has the potential to lower costs and power consumption by using an order of magnitude fewer discrete voltage levels. Performance is bolstered by combining the discretized signal with the knowledge of the underlying pulse shape. Simulated FIPSER data was reconstructed with two independent methods. One using a maximum likelihood method and the other using a modified χ2 test. Both methods show that utilizing 12 discrete voltage levels with a sampling rate of 4 samples per full width half maximum (FWHM) of the pulse achieves an amplitude resolution that is better than the Poisson limit for photon-counting experiments. The time resolution achieved in this configuration ranges between 0.02 and 0.16 FWHM and depends on the pulse amplitude. In a situation where the waveform is composed of two consecutive pulses the pulses can be separated if they are at least 0.05-0.30 FWHM apart with an amplitude resolution that is better than 20%.

  4. Impact of a Gender-Transformative HIV and Antiviolence Program on Gender Ideologies and Masculinities in Two Rural, South African Communities.

    Science.gov (United States)

    Dworkin, Shari L; Hatcher, Abigail M; Colvin, Chris; Peacock, Dean

    2013-06-01

    "One Man Can" (OMC) is a rights-based gender equality and health program implemented by Sonke Gender Justice Network (Sonke) in South Africa. The program seeks to reduce the spread and impact of HIV and AIDS and reduce violence against women and men. To understand how OMC workshops impact masculinities, gender norms, and perceptions of women's rights, an academic/non-governmental organization (NGO) partnership was carried out with the University of Cape Town, the University of California at San Francisco, and Sonke. Sixty qualitative, in-depth interviews were carried out with men who had completed OMC workshops and who were recruited from Sonke's partner organizations that were focused on gender and/or health-related services. Men were recruited who were over age 18 and who participated in OMC workshops in Limpopo and Eastern Cape Provinces, South Africa. Results reveal how men reconfigured notions of hegemonic masculinity both in terms of beliefs and practices in relationships, households, and in terms of women's rights. In the conclusions, we consider the ways in which the OMC program extends public health research focused on masculinities, violence, and HIV/AIDS. We then critically assess the ways in which health researchers and practitioners can bolster men's engagement within programs focused on gender equality and health.

  5. TOPICAL REVIEW: Stem cells engineering for cell-based therapy

    Science.gov (United States)

    Taupin, Philippe

    2007-09-01

    Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.

  6. Patterns and biases in climate change research on amphibians and reptiles: a systematic review

    Science.gov (United States)

    2016-01-01

    Climate change probably has severe impacts on animal populations, but demonstrating a causal link can be difficult because of potential influences by additional factors. Assessing global impacts of climate change effects may also be hampered by narrow taxonomic and geographical research foci. We review studies on the effects of climate change on populations of amphibians and reptiles to assess climate change effects and potential biases associated with the body of work that has been conducted within the last decade. We use data from 104 studies regarding the effect of climate on 313 species, from 464 species–study combinations. Climate change effects were reported in 65% of studies. Climate change was identified as causing population declines or range restrictions in half of the cases. The probability of identifying an effect of climate change varied among regions, taxa and research methods. Climatic effects were equally prevalent in studies exclusively investigating climate factors (more than 50% of studies) and in studies including additional factors, thus bolstering confidence in the results of studies exclusively examining effects of climate change. Our analyses reveal biases with respect to geography, taxonomy and research question, making global conclusions impossible. Additional research should focus on under-represented regions, taxa and questions. Conservation and climate policy should consider the documented harm climate change causes reptiles and amphibians. PMID:27703684

  7. Constraining the last 7 billion years of galaxy evolution in semi-analytic models

    CERN Document Server

    Mutch, Simon J; Croton, Darren J

    2012-01-01

    We investigate the ability of the Croton et al. (2006) semi-analytic model to reproduce the evolution of observed galaxies across the final 7 billion years of cosmic history. Using Monte-Carlo Markov Chain techniques we explore the available parameter space to produce a model which attempts to achieve a statistically accurate fit to the observed stellar mass function at z=0 and z~0.8, as well as the local black hole-bulge relation. We find that in order to be successful we are required to push supernova feedback efficiencies to extreme limits which are, in some cases, unjustified by current observations. This leads us to the conclusion that the current model may be incomplete. Using the posterior probability distributions provided by our fitting, as well as the qualitative details of our produced stellar mass functions, we suggest that any future model improvements must act to preferentially bolster star formation efficiency in the most massive halos at high redshift.

  8. search.bioPreprint: a discovery tool for cutting edge, preprint biomedical research articles.

    Science.gov (United States)

    Iwema, Carrie L; LaDue, John; Zack, Angela; Chattopadhyay, Ansuman

    2016-01-01

    The time it takes for a completed manuscript to be published traditionally can be extremely lengthy. Article publication delay, which occurs in part due to constraints associated with peer review, can prevent the timely dissemination of critical and actionable data associated with new information on rare diseases or developing health concerns such as Zika virus. Preprint servers are open access online repositories housing preprint research articles that enable authors (1) to make their research immediately and freely available and (2) to receive commentary and peer review prior to journal submission. There is a growing movement of preprint advocates aiming to change the current journal publication and peer review system, proposing that preprints catalyze biomedical discovery, support career advancement, and improve scientific communication. While the number of articles submitted to and hosted by preprint servers are gradually increasing, there has been no simple way to identify biomedical research published in a preprint format, as they are not typically indexed and are only discoverable by directly searching the specific preprint server websites. To address this issue, we created a search engine that quickly compiles preprints from disparate host repositories and provides a one-stop search solution. Additionally, we developed a web application that bolsters the discovery of preprints by enabling each and every word or phrase appearing on any web site to be integrated with articles from preprint servers. This tool, search.bioPreprint, is publicly available at http://www.hsls.pitt.edu/resources/preprint.

  9. Radioxenon spiked air.

    Science.gov (United States)

    Watrous, Matthew G; Delmore, James E; Hague, Robert K; Houghton, Tracy P; Jenson, Douglas D; Mann, Nick R

    2015-12-01

    Four of the radioactive xenon isotopes ((131m)Xe, (133m)Xe, (133)Xe and (135)Xe) with half-lives ranging from 9 h to 12 days are produced from nuclear fission and can be detected from days to weeks following their production and release. Being inert gases, they are readily transported through the atmosphere. Sources for release of radioactive xenon isotopes include operating nuclear reactors via leaks in fuel rods, medical isotope production facilities, and nuclear weapons' detonations. They are not normally released from fuel reprocessing due to the short half-lives. The Comprehensive Nuclear-Test-Ban Treaty has led to creation of the International Monitoring System. The International Monitoring System, when fully implemented, will consist of one component with 40 stations monitoring radioactive xenon around the globe. Monitoring these radioactive xenon isotopes is important to the Comprehensive Nuclear-Test-Ban Treaty in determining whether a seismically detected event is or is not a nuclear detonation. A variety of radioactive xenon quality control check standards, quantitatively spiked into various gas matrices, could be used to demonstrate that these stations are operating on the same basis in order to bolster defensibility of data across the International Monitoring System. This paper focuses on Idaho National Laboratory's capability to produce three of the xenon isotopes in pure form and the use of the four xenon isotopes in various combinations to produce radioactive xenon spiked air samples that could be subsequently distributed to participating facilities.

  10. Of Stars and Harlow Shapley

    Science.gov (United States)

    Palmeri, J.

    2016-01-01

    For much of the twentieth century, the astronomer and longtime director of the Harvard College Observatory, Harlow Shapley (1885-1972), embodied the public face of astronomy. From the 1920s through the 1960s he introduced millions to the wonders of the night sky. His compelling vision of humanity's place in the universe and moving message about cosmic connections inspired many who had never looked through a telescope, visited a planetarium, or taken an astronomy class. He encouraged readers and audiences to learn more about astronomy and other sciences. Over the course of a long career, Shapley not only bolstered the image of astronomy, but also the role of the astronomer as a public intellectual and spokesperson for science. Shapley's early years on the newspaper beat honed his storytelling, and he then put these skills to use as a promoter and fundraiser for astronomy and science at Harvard. He used a variety of means to convey his message beyond the observatory, including radio talks, lectures, magazine articles, television appearances, and popular books. He also narrated an award-winning animated film based on one of his most widely read books, Of Stars and Men. Through words, voice, and visuals, Shapley offered the world an eloquent perspective on the cosmos and a timely message about the significance of science for society. In this paper I focus on how Shapley conveyed the meaning and value of astronomical inquiry, and I explore audience reception of the messages and images he used to popularize astronomy.

  11. Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.

    Science.gov (United States)

    Lee, Jaewon; Jo, Dong-Gyu; Park, Daeui; Chung, Hae Young; Mattson, Mark P

    2014-07-01

    During the past 5 decades, it has been widely promulgated that the chemicals in plants that are good for health act as direct scavengers of free radicals. Here we review evidence that favors a different hypothesis for the health benefits of plant consumption, namely, that some phytochemicals exert disease-preventive and therapeutic actions by engaging one or more adaptive cellular response pathways in cells. The evolutionary basis for the latter mechanism is grounded in the fact that plants produce natural antifeedant/noxious chemicals that discourage insects and other organisms from eating them. However, in the amounts typically consumed by humans, the phytochemicals activate one or more conserved adaptive cellular stress response pathways and thereby enhance the ability of cells to resist injury and disease. Examplesof such pathways include those involving the transcription factors nuclear factor erythroid 2-related factor 2, nuclear factor-κB, hypoxia-inducible factor 1α, peroxisome proliferator-activated receptor γ, and forkhead box subgroup O, as well as the production and action of trophic factors and hormones. Translational research to develop interventions that target these pathways may lead to new classes of therapeutic agents that act by stimulating adaptive stress response pathways to bolster endogenous defenses against tissue injury and disease. Because neurons are particularly sensitive to potentially noxious phytochemicals, we focus on the nervous system but also include findings from other cell types in which actions of phytochemicals on specific signal transduction pathways have been more thoroughly studied.

  12. Exploiting dimensionality and defect mitigation to create tunable microwave dielectrics

    Science.gov (United States)

    Lee, Che-Hui; Orloff, Nathan D.; Birol, Turan; Zhu, Ye; Goian, Veronica; Rocas, Eduard; Haislmaier, Ryan; Vlahos, Eftihia; Mundy, Julia A.; Kourkoutis, Lena F.; Nie, Yuefeng; Biegalski, Michael D.; Zhang, Jingshu; Bernhagen, Margitta; Benedek, Nicole A.; Kim, Yongsam; Brock, Joel D.; Uecker, Reinhard; Xi, X. X.; Gopalan, Venkatraman; Nuzhnyy, Dmitry; Kamba, Stanislav; Muller, David A.; Takeuchi, Ichiro; Booth, James C.; Fennie, Craig J.; Schlom, Darrell G.

    2013-10-01

    The miniaturization and integration of frequency-agile microwave circuits--relevant to electronically tunable filters, antennas, resonators and phase shifters--with microelectronics offers tantalizing device possibilities, yet requires thin films whose dielectric constant at gigahertz frequencies can be tuned by applying a quasi-static electric field. Appropriate systems such as BaxSr1-xTiO3 have a paraelectric-ferroelectric transition just below ambient temperature, providing high tunability. Unfortunately, such films suffer significant losses arising from defects. Recognizing that progress is stymied by dielectric loss, we start with a system with exceptionally low loss--Srn+1TinO3n+1 phases--in which (SrO)2 crystallographic shear planes provide an alternative to the formation of point defects for accommodating non-stoichiometry. Here we report the experimental realization of a highly tunable ground state arising from the emergence of a local ferroelectric instability in biaxially strained Srn+1TinO3n+1 phases with n>=3 at frequencies up to 125GHz. In contrast to traditional methods of modifying ferroelectrics--doping or strain--in this unique system an increase in the separation between the (SrO)2 planes, which can be achieved by changing n, bolsters the local ferroelectric instability. This new control parameter, n, can be exploited to achieve a figure of merit at room temperature that rivals all known tunable microwave dielectrics.

  13. U-2 Spy Plane With Fictitious NASA Markings

    Science.gov (United States)

    1960-01-01

    After Francis Gary Powers was shot down over the Soviet Union during a CIA spy flight on May 1. 1960, NASA issued a press release with a cover story about a U-2 conducting weather research that may have strayed off course after the pilot reported difficulties with his oxygen equipment. To bolster the cover-up, a U-2 was quickly painted in NASA markings, with a fictitious NASA serial number, and put on display for the news media at the NASA Flight Research Center at Edwards Air Force Base on May 6, 1960. The U-2 cover story in 1956 was that it was an NACA plane to conduct high-altitude weather research. But various observers doubted this story from the beginning. Certainly the Soviets did not believe it once the aircraft began overflying their territory. The NASA cover story quickly blew up in the agency's face when both Gary Powers and aircraft wreckage were displayed by the Soviet Union, proving that it was a reconnaissance aircraft. This caused embarrassment for several top NASA officials.

  14. HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1.

    Science.gov (United States)

    Qian, Shuiming; Zhong, Xuehua; Yu, Lianbo; Ding, Biao; de Haan, Peter; Boris-Lawrie, Kathleen

    2009-01-13

    The RNA silencing pathway is an intracellular innate response to virus infections and retro-transposons. Many plant viruses counter this host restriction by RNA silencing suppressor (RSS) activity of a double-stranded RNA-binding protein, e.g., tomato bushy stunt virus P19. Here, we demonstrate P19 and HIV-1 Tat function across the plant and animal kingdoms and suppress a common step in RNA silencing that is downstream of small RNA maturation. Our experiments reveal that RNA silencing in HIV-1 infected human cells severely attenuates the translational output of the unspliced HIV-1 gag mRNA, and possibly all HIV-1 transcripts. The attenuation in gag mRNA translation is exacerbated by K51A substitution in the Tat double-stranded RNA-binding domain. Tat, plant virus RSS, or Dicer downregulation rescues robust gag translation and bolsters HIV-1 virion production. The reversal of HIV-1 translation repression by plant RSS supports the recent finding in Arabidopsis that plant miRNAs operate by translational inhibition. Our results identify common features between RNA silencing suppression of plant and animal viruses. We suggest that RNA silencing-mediated translation repression plays a strategic role in determining the viral set-point in a newly HIV-1-infected patient.

  15. Pseudo-De Novo Assembly and Analysis of Unmapped Genome Sequence Reads in Wild Zebrafish Reveal Novel Gene Content.

    Science.gov (United States)

    Faber-Hammond, Joshua J; Brown, Kim H

    2016-04-01

    Zebrafish represents the third vertebrate with an officially completed genome, yet it remains incomplete with additions and corrections continuing with the current release, GRCz10, having 13% of zebrafish cDNA sequences unmapped. This disparity may result from population differences, given that the genome reference was generated from clonal individuals with limited genetic diversity. This is supported by the recent analysis of a single wild zebrafish, which identified over 5.2 million SNPs and 1.6 million in/dels in the previous genome build, zv9. Re-examination of this sequence data set indicated that 13.8% of quality sequence reads failed to align to GRCz10. Using a novel bioinformatics de novo assembly pipeline on these unmappable reads, we identified 1,514,491 novel contigs covering ∼224 Mb of genomic sequence. Among these, 1083 contigs were found to contain a potential gene coding sequence. RNA-seq data comparison confirmed that 362 contigs contained a transcribed DNA sequence, suggesting that a large amount of functional genomic sequence remains unannotated in the zebrafish reference genome. By utilizing the bioinformatics pipeline developed in this study, the zebrafish genome will be bolstered as a model for human disease research. Adaptation of the pipeline described here also offers a cost-efficient and effective method to identify and map novel genetic content across any genome and will ultimately aid in the completion of additional genomes for a broad range of species.

  16. Differences in psychiatric symptoms and barriers to mental health care between volunteer and career firefighters.

    Science.gov (United States)

    Stanley, Ian H; Boffa, Joseph W; Hom, Melanie A; Kimbrel, Nathan A; Joiner, Thomas E

    2017-01-01

    Firefighters are at increased risk for mental health problems. However, little is known about differences in psychiatric symptoms between volunteer and career firefighters. This study aimed to (1) describe differences in psychiatric symptoms and barriers to mental health care between U.S. firefighters in volunteer-only and career-only departments; and (2) determine if greater self-reported structural barriers to mental health care (e.g., cost, availability of resources) explain the differences in psychiatric symptom levels. Overall, 525 current U.S. firefighters participated. Analyses of covariance and logistic regression analyses were used to evaluate group differences between volunteer (n=204) and career (n=321) firefighters, adjusting for demographic and occupational characteristics. Volunteer firefighters reported significantly elevated levels of depression, posttraumatic stress, and suicidal symptoms compared to career firefighters. Career firefighters reported relatively elevated levels of problematic alcohol use. Volunteer firefighters additionally reported greater structural barriers to mental health care (e.g., cost, availability of resources), and these barriers accounted for the differences in mental health variables between volunteer and career firefighters. Findings suggest that volunteer firefighters report elevated psychiatric symptoms compared to career firefighters and greater structural barriers to mental health treatment may explain this link. Increased efforts are needed to develop firefighter-specific interventions and bolster mental health service utilization.

  17. Cooling the Planet: Opportunities for Deployment of Superefficient Room Air Conditioners

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Nihar [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Waide, Paul [Navigant Consulting Inc., Chicago, IL (United States); Phadke, Amol [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-04-01

    This report presents the results of an analysis, commissioned by the U.S. Department of Energy, of Air Conditioner (AC) efficiency in support of the Super-efficient Equipment and Appliance Deployment (SEAD) initiative.1 The International Energy Studies group at Lawrence Berkeley National Laboratory in collaboration with Navigant Consulting Inc. performed the analysis. SEAD aims to transform the global market by increasing the penetration of highly efficient equipment and appliances. SEAD partners work together in voluntary activities to: (1) “raise the efficiency ceiling” by pulling superefficient appliances and equipment into the market through cooperation on measures like incentives, procurement, awards, and research and development (R&D) investments; (2) “raise the efficiency floor” by working together to bolster national or regional policies like minimum efficiency standards; and (3) “strengthen the efficiency foundations” of programs by coordinating technical work to support these activities.2 The objective of this analysis is to provide the background technical information necessary to improve the efficiency of ACs and to provide a foundation for the activities of SEAD participating countries. We find that even the best currently available technology offers large efficiency improvement opportunities (35% to 50% reduction in energy consumption from the market average) in most SEAD countries. The cost effective efficiency improvements range from 20% to 30% reduction in energy consumption based on a consumer perspective.

  18. Bringing Back the Social Affordances of the Paper Memo to Aerospace Systems Engineering Work

    Science.gov (United States)

    Davidoff, Scott; Holloway, Alexandra

    2014-01-01

    Model-based systems engineering (MBSE) is a relatively new field that brings together the interdisciplinary study of technological components of a project (systems engineering) with a model-based ontology to express the hierarchical and behavioral relationships between the components (computational modeling). Despite the compelling promises of the benefits of MBSE, such as improved communication and productivity due to an underlying language and data model, we observed hesitation to its adoption at the NASA Jet Propulsion Laboratory. To investigate, we conducted a six-month ethnographic field investigation and needs validation with 19 systems engineers. This paper contributes our observations of a generational shift in one of JPL's core technologies. We report on a cultural misunderstanding between communities of practice that bolsters the existing technology drag. Given the high cost of failure, we springboard our observations into a design hypothesis - an intervention that blends the social affordances of the narrative-based work flow with the rich technological advantages of explicit data references and relationships of the model-based approach. We provide a design rationale, and the results of our evaluation.

  19. Flowing with the changing needs of hydrogeology instruction

    Science.gov (United States)

    Gleeson, T.; Allen, D. M.; Ferguson, G.

    2012-01-01

    Hydrogeology is now taught in a broad spectrum of departments and institutions to students with diverse backgrounds. Successful instruction in hydrogeology thus requires a variety of pedagogical approaches depending on desired learning outcomes and the diverse background of students. We review the pedagogical literature in hydrogeology to highlight recent advances and analyze a 2005 survey of 68 hydrogeology instructors. The literature and survey results suggest there are ~15 topics that are considered crucial by most hydrogeologists and >100 other topics that are considered crucial by some hydrogeologists. The crucial topics focus on properties of aquifers and fundamentals of groundwater flow, and should likely be part of all undergraduate hydrogeology courses. Other topics can supplement and support these crucial topics, depending on desired learning outcomes. Classroom settings continue to provide a venue for emphasizing fundamental knowledge. However, recent pedagogical advances are biased towards field and laboratory instruction with a goal of bolstering experiential learning. Field methods build on the fundamentals taught in the classroom and emphasize the collection of data, data uncertainty, and the development of vocational skills. Laboratory and computer-based exercises similarly build on theory, and offer an opportunity for data analysis and integration. The literature suggests curricula at all levels should ideally balance field, laboratory, and classroom pedagogy into an iterative and integrative whole. An integrated approach leads to greater student motivation and advancement of theoretical and vocational knowledge.

  20. Teaching hydrogeology: a review of current practice

    Science.gov (United States)

    Gleeson, T.; Allen, D. M.; Ferguson, G.

    2012-07-01

    Hydrogeology is now taught in a broad spectrum of departments and institutions to students with diverse backgrounds. Successful instruction in hydrogeology thus requires a variety of pedagogical approaches depending on desired learning outcomes and the background of students. We review the pedagogical literature in hydrogeology to highlight recent advances and analyze a 2005 survey among 68 hydrogeology instructors. The literature and survey results suggest there are only ~ 15 topics that are considered crucial by most hydrogeologists and > 100 other topics that are considered crucial by some hydrogeologists. The crucial topics focus on properties of aquifers and fundamentals of groundwater flow, and should likely be part of all undergraduate hydrogeology courses. Other topics can supplement and support these crucial topics, depending on desired learning outcomes. Classroom settings continue to provide a venue for emphasizing fundamental knowledge. However, recent pedagogical advances are biased towards field and laboratory instruction with a goal of bolstering experiential learning. Field methods build on the fundamentals taught in the classroom and emphasize the collection of data, data uncertainty, and the development of vocational skills. Laboratory and computer-based exercises similarly build on theory, and offer an opportunity for data analysis and integration. The literature suggests curricula at all levels should ideally balance field, laboratory, and classroom pedagogy into an iterative and integrative whole. An integrated, iterative and balanced approach leads to greater student motivation and advancement of theoretical and vocational knowledge.

  1. Presynaptic α₂-adrenoceptors control the inhibitory action of presynaptic CB₁ cannabinoid receptors on prefrontocortical norepinephrine release in the rat.

    Science.gov (United States)

    Richter, Hardy; Teixeira, Filipe M; Ferreira, Samira G; Kittel, Ágnes; Köfalvi, Attila; Sperlágh, Beáta

    2012-10-01

    Endocannabinoids play a crucial neuromodulator role in both physiological and pathological states in various brain regions including the prefrontal cortex (PFC). We examined, whether presynaptic cannabinoid receptors are involved in the modulation of basal and electrical field stimulation-evoked [³H]norepinephrine ([³H]NE) release from rat PFC slices. WIN55,212-2, a nonselective CB₁ receptor (CB₁R) agonist, inhibited the electrical stimulation-evoked efflux of [³H]NE in a concentration-dependent fashion, which was antagonized by the CB₁R antagonist/inverse agonist, AM251 (1 μM). Idazoxan, a selective α₂-adrenoceptor antagonist, augmented the evoked [³H]NE release. In the presence of idazoxan, the effect of WIN55,212-2 was exacerbated or attenuated, depending on the applied concentration and stimulation frequency. Moreover their combined, but not individual application elicited a depressive-like phenomenon in the forced-swim test. These data were bolstered with fluorescent and confocal microscopy analysis, which revealed that CB₁R immunoreactivity co-localized with dopamine-β-hydroxylase positive (i.e. noradrenergic) fibers and the inhibitory α(2A) adrenergic autoreceptors (α(2A)R) in the PFC. Furthermore, idazoxan triggered a decrease in CB₁R density in the PFC, suggesting that high extracellular level of norepinephrine downregulates CB₁Rs.

  2. The Benefits of Volunteering as an Oral and Maxillofacial Surgery Educator.

    Science.gov (United States)

    Nix, Ned L; Beck, Lynn G; Rodriguez, Tobias E

    2016-07-01

    A faculty shortage crisis exists in oral and maxillofacial surgery (OMS) education affecting dental students, OMS residents, and OMS full-time faculty. This report was designed to help nonacademic OMS practitioners better understand the problem and appreciate the potential benefits of volunteering as a part-time faculty member. Volunteer part-time faculty can help bolster the efforts of the faculty leaders (full-time and part-time) by taking on some of the dental student and/or resident educational responsibilities. They can also help free up some of the full-time faculty members' time to allow them to complete the scholarly activities required of full-time academicians. Volunteer part-time faculty can greatly benefit from their involvement in dental education. Exposure to faculty leaders and dental students and residents can be educationally enriching and stimulating for volunteer part-time faculty. Students and residents will benefit from learning the differing approaches to patient management that volunteer part-time faculty can provide. In addition, volunteer part-time faculty can have a scope of practice or practice emphasis that differs from and complements that of the faculty leaders. Finally, residents can also benefit from exposure to private practice management strategies that volunteer part-time faculty share. The present report explores how all parties can benefit from OMS faculty volunteerism.

  3. Psychological treatments for gambling disorder

    Directory of Open Access Journals (Sweden)

    Rash CJ

    2014-10-01

    Full Text Available Carla J Rash, Nancy M Petry Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA Abstract: This review discusses the research evidence for psychological treatment of gambling disorder. Several treatment options for gamblers have been explored, ranging from self-help and peer support, to brief and motivational interventions, to more intensive therapy approaches. Involvement in peer support programs seems to be optimal when combined with professional treatment; however, engagement and retention in peer support is limited. Self-directed interventions appear to benefit some gamblers; however, the involvement of therapist support, either in person or by telephone, may bolster these effects and such support need not be extensive. These self-directed options reduce the barriers associated with treatment-seeking, and may reach a wider range of gamblers than professionally delivered treatments alone. Brief and motivational approaches similarly may extend treatment options to more gamblers, namely at-risk and problem gamblers and those not seeking treatment. Of more extensive therapies, no consistent benefit of one approach emerges, although cognitive–behavioral interventions have been most often applied. Overall, several treatments have been developed for gambling disorder and results are promising, but variability in findings suggests a need for further systematic evaluation. Keywords: gambling treatment, cognitive behavioral treatment, brief interventions, pathological gambling, problem gambling, behavioral addictions

  4. Where does fitness fit in theories of perception?

    Science.gov (United States)

    Anderson, Barton L

    2015-12-01

    Interface theory asserts that neither our perceptual experience of the world nor the scientific constructs used to describe the world are veridical. The primary argument used to uphold this claim is that (1) evolution is driven by a process of natural selection that favors fitness over veridicality, and (2) payoffs do not vary monotonically with truth. I argue that both the arguments used to bolster this claim and the conclusions derived from it are flawed. Interface theory assumes that perception evolved to directly track fitness but fails to consider the role of adaptation on ontogenetic time scales. I argue that the ubiquity of nonmonotonic payoff functions requires that (1) perception tracks "truth" for species that adapt on ontogenetic time scales and (2) that perception should be distinct from utility. These conditions are required to pursue an adaptive strategy to mitigate homeostatic imbalances. I also discuss issues with the interface metaphor, the particular formulation of veridicality that is considered, and the relationship of interface theory to the history of ideas on these topics.

  5. Viewpoint: physician, know thyself: the professional culture of medicine as a framework for teaching cultural competence.

    Science.gov (United States)

    Boutin-Foster, Carla; Foster, Jordan C; Konopasek, Lyuba

    2008-01-01

    The need for physicians who are well equipped to treat patients of diverse social and cultural backgrounds is evident. To this end, cultural competence education programs in medical schools have proliferated. Although these programs differ in duration, setting, and content, their intentions are the same: to bolster knowledge, promote positive attitudes, and teach appropriate skills in cultural competence. However, to advance the current state of cultural competence curricula, a number of challenges have to be addressed. One challenge is overcoming learner resistance, a problem that is encountered when attempting to convey the importance of cultural competence to students who view it as a "soft science." There is also the challenge of avoiding the perpetuation of stereotypes and labeling groups as "others" in the process of teaching cultural competence. An additional challenge is that few cultural competence curricula are specifically designed to foster an awareness of the student's own cultural background. The authors propose the professional culture of medicine as a framework to cultural competence education that may help mitigate these challenges. Rather than focusing on patients as the "other" group, this framework explores the customs, languages, and beliefs systems that are shared by physicians, thus defining medicine as a culture. Focusing on the physician's culture may help to broaden students' concept of culture and may sensitize them to the importance of cultural competence. The authors conclude with suggestions on how students can explore the professional culture of medicine through the exploration of films, role-playing, and the use of written narratives.

  6. Mutualism Disruption Threatens Global Plant Biodiversity: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    Clare E Aslan

    Full Text Available As global environmental change accelerates, biodiversity losses can disrupt interspecific interactions. Extinctions of mutualist partners can create "widow" species, which may face reduced ecological fitness. Hypothetically, such mutualism disruptions could have cascading effects on biodiversity by causing additional species coextinctions. However, the scope of this problem - the magnitude of biodiversity that may lose mutualist partners and the consequences of these losses - remains unknown.We conducted a systematic review and synthesis of data from a broad range of sources to estimate the threat posed by vertebrate extinctions to the global biodiversity of vertebrate-dispersed and -pollinated plants. Though enormous research gaps persist, our analysis identified Africa, Asia, the Caribbean, and global oceanic islands as geographic regions at particular risk of disruption of these mutualisms; within these regions, percentages of plant species likely affected range from 2.1-4.5%. Widowed plants are likely to experience reproductive declines of 40-58%, potentially threatening their persistence in the context of other global change stresses.Our systematic approach demonstrates that thousands of species may be impacted by disruption in one class of mutualisms, but extinctions will likely disrupt other mutualisms, as well. Although uncertainty is high, there is evidence that mutualism disruption directly threatens significant biodiversity in some geographic regions. Conservation measures with explicit focus on mutualistic functions could be necessary to bolster populations of widowed species and maintain ecosystem functions.

  7. Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines

    Directory of Open Access Journals (Sweden)

    Marc Mansour

    2011-08-01

    Full Text Available Chemotherapy has been a mainstay in cancer treatment for many years. Despite some success, the cure rate with chemotherapy remains unsatisfactory in some types of cancers, and severe side effects from these treatments are a concern. Recently, understanding of the dynamic interplay between the tumor and immune system has led to the development of novel immunotherapies, including cancer vaccines. Cancer vaccines have many advantageous features, but their use has been hampered by poor immunogenicity. Many developments have increased their potency in pre-clinical models, but cancer vaccines continue to have a poor clinical track record. In part, this could be due to an inability to effectively overcome tumor-induced immune suppression. It had been generally assumed that immune-stimulatory cancer vaccines could not be used in combination with immunosuppressive chemotherapies, but recent evidence has challenged this dogma. Chemotherapies could be used to condition the immune system and tumor to create an environment where cancer vaccines have a better chance of success. Other types of immunotherapies could also be used to modulate the immune system. This review will discuss how immune modulation by chemotherapy or immunotherapy could be used to bolster the effects of cancer vaccines and discuss the advantages and disadvantages of these treatments.

  8. Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.

    Science.gov (United States)

    Janes, K; Symons-Liguori, A M; Jacobson, K A; Salvemini, D

    2016-04-01

    Chronic pain negatively impacts the quality of life in a variety of patient populations. The current therapeutic repertoire is inadequate in managing patient pain and warrants the development of new therapeutics. Adenosine and its four cognate receptors (A1 , A2A , A2B and A3 ) have important roles in physiological and pathophysiological states, including chronic pain. Preclinical and clinical studies have revealed that while adenosine and agonists of the A1 and A2A receptors have antinociceptive properties, their therapeutic utility is limited by adverse cardiovascular side effects. In contrast, our understanding of the A3 receptor is only in its infancy, but exciting preclinical observations of A3 receptor antinociception, which have been bolstered by clinical trials of A3 receptor agonists in other disease states, suggest pain relief without cardiovascular side effects and with sufficient tolerability. Our goal herein is to briefly discuss adenosine and its receptors in the context of pathological pain and to consider the current data regarding A3 receptor-mediated antinociception. We will highlight recent findings regarding the impact of the A3 receptor on pain pathways and examine the current state of selective A3 receptor agonists used for these studies. The adenosine-to-A3 receptor pathway represents an important endogenous system that can be targeted to provide safe, effective pain relief from chronic pain.

  9. Identification and Characterisation CRN Effectors in Phytophthora capsici Shows Modularity and Functional Diversity

    Science.gov (United States)

    Stam, Remco; Jupe, Julietta; Howden, Andrew J. M.; Morris, Jenny A.; Boevink, Petra C.; Hedley, Pete E.; Huitema, Edgar

    2013-01-01

    Phytophthora species secrete a large array of effectors during infection of their host plants. The Crinkler (CRN) gene family encodes a ubiquitous but understudied class of effectors with possible but as of yet unknown roles in infection. To appreciate CRN effector function in Phytophthora, we devised a simple Crn gene identification and annotation pipeline to improve effector prediction rates. We predicted 84 full-length CRN coding genes and assessed CRN effector domain diversity in sequenced Oomycete genomes. These analyses revealed evidence of CRN domain innovation in Phytophthora and expansion in the Peronosporales. We performed gene expression analyses to validate and define two classes of CRN effectors, each possibly contributing to infection at different stages. CRN localisation studies revealed that P. capsici CRN effector domains target the nucleus and accumulate in specific sub-nuclear compartments. Phenotypic analyses showed that few CRN domains induce necrosis when expressed in planta and that one cell death inducing effector, enhances P. capsici virulence on Nicotiana benthamiana. These results suggest that the CRN protein family form an important class of intracellular effectors that target the host nucleus during infection. These results combined with domain expansion in hemi-biotrophic and necrotrophic pathogens, suggests specific contributions to pathogen lifestyles. This work will bolster CRN identification efforts in other sequenced oomycete species and set the stage for future functional studies towards understanding CRN effector functions. PMID:23536880

  10. Placentation in mammals once grouped as insectivores.

    Science.gov (United States)

    Carter, Anthony M; Enders, Allen C

    2010-01-01

    Interest in insectivoran grade mammals has been reawakened by taxonomic changes that place tenrecs and golden moles in a new order and separate hedgehogs from moles, shrews and solenodons. This survey of their placentation shows there is great variation even within families. As an example three subfamilies of tenrec have been examined. The interhemal region is cellular hemomonochorial in Echinops and Microgale but endotheliochorial in Micropotamogale. Golden moles, which are placed in the same order, have hemodichorial placentation. Many insectivores have complex arrangements for histotrophic nutrition involving columnar trophoblast cells. These range from areolae in moles through complexly folded hemophagous regions in tenrecs to the trophoblastic annulus in shrews. Of these placental characters, few offer support to current phylogenies. However, the case for placing hedgehogs and gymnures in a separate order (Erinaceomorpha) is bolstered by the presence of interstitial implantation, amniogenesis by cavitation, a hemochorial barrier and a prominent spongy zone; these features do not occur in shrews, moles or solenodons (Soricomorpha). Three insectivoran grade mammals deserve close attention as they have been selected for genome sequencing. One of these, the European hedgehog (Erinaceus europaeus), has not been studied with current methodology and renewed investigation of this or the closely related genus Atelerix should be a priority.

  11. Slip-Sliding on a Yellow Brick Road: Stabilization Efforts in Afghanistan

    Directory of Open Access Journals (Sweden)

    Vanda Felbab-Brown

    2012-11-01

    Full Text Available The ongoing transition process in Afghanistan will deliver three shocks in the coming few years: foreign forces will complete the handover of security responsibility to their Afghan counterparts, aid volumes and international spending in the country will decrease and, lastly, the political dispensation will be upended by presidential elections in which President Hamid Karzai is not supposed to run again. These challenges are mounting at a time when, due to inconsistent international approaches and a lack of appreciation for the Afghan context, Afghanistan is dealing with rising insecurity, dysfunctional governance, rampant corruption, and ethnic factionalization within the society and the domestic security forces. Based upon a review of the security sector, governance, social and economic conditions, regional relations and negotiation efforts with the insurgents, this article finds that fundamental questions about the efficacy of stabilization efforts in Afghanistan continue to lack clear answers. Regardless, significant room for improvement – both in policy and execution – appears to exist. It remains to be seen whether, as many Afghans fear, a civil war will engulf Afghanistan once again in the post-transition period or whether the international community will take those steps – re-energizing governance reform efforts, maintaining financial support and continuing to strengthen the Afghan army and police – which could help to bolster stability.

  12. Electrocardiogram-assisted blood pressure estimation.

    Science.gov (United States)

    Ahmad, Saif; Chen, Silu; Soueidan, Karen; Batkin, Izmail; Bolic, Miodrag; Dajani, Hilmi; Groza, Voicu

    2012-03-01

    Accurate automatic noninvasive assessment of blood pressure (BP) presents a challenge due to conditions like arrhythmias, obesity, and postural changes that tend to obfuscate arterial amplitude pulsations sensed by the cuff. Researchers tried to overcome this challenge by analyzing oscillometric pulses with the aid of a higher fidelity signal-the electrocardiogram (ECG). Moreover, pulse transit time (PTT) was employed to provide an additional method for BP estimation. However, these methods were not fully developed, suitably integrated, or tested. To address these issues, we present a novel method whereby ECG-assisted oscillometric and PTT (measured between ECG R-peaks and maximum slope of arterial pulse peaks) analyses are seamlessly integrated into the oscillometric BP measurement paradigm. The method bolsters oscillometric analysis (amplitude modulation) with more reliable ECG R-peaks provides a complementary measure with PTT analysis (temporal modulation) and fuses this information for robust BP estimation. We have integrated this technology into a prototype that comprises a BP cuff with an embedded conductive fabric ECG electrode, associated hardware, and algorithms. A pilot study has been undertaken on ten healthy subjects (150 recordings) to validate the performance of our prototype against United States Food and Drug Administration approved Omron oscillometric monitor (HEM-790IT). Our prototype achieves mean absolute difference of less than 5 mmHg and grade A as per the British Hypertension Society protocol for estimating BP, with the reference Omron monitor.

  13. The clinical translation gap in child health exercise research: a call for disruptive innovation.

    Science.gov (United States)

    Ashish, Naveen; Bamman, Marcas M; Cerny, Frank J; Cooper, Dan M; D'Hemecourt, Pierre; Eisenmann, Joey C; Ericson, Dawn; Fahey, John; Falk, Bareket; Gabriel, Davera; Kahn, Michael G; Kemper, Han C G; Leu, Szu-Yun; Liem, Robert I; McMurray, Robert; Nixon, Patricia A; Olin, J Tod; Pianosi, Paolo T; Purucker, Mary; Radom-Aizik, Shlomit; Taylor, Amy

    2015-02-01

    In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.

  14. TAT and HA2 facilitate cellular uptake of gold nanoparticles but do not lead to cytosolic localisation.

    Science.gov (United States)

    Cesbron, Yann; Shaheen, Umbreen; Free, Paul; Lévy, Raphaël

    2015-01-01

    The methods currently available to deliver functional labels and drugs to the cell cytosol are inefficient and this constitutes a major obstacle to cell biology (delivery of sensors and imaging probes) and therapy (drug access to the cell internal machinery). As cell membranes are impermeable to most molecular cargos, viral peptides have been used to bolster their internalisation through endocytosis and help their release to the cytosol by bursting the endosomal vesicles. However, conflicting results have been reported on the extent of the cytosolic delivery achieved. To evaluate their potential, we used gold nanoparticles as model cargos and systematically assessed how the functionalisation of their surface by either or both of the viral peptides TAT and HA2 influenced their intracellular delivery. We evaluated the number of gold nanoparticles present in cells after internalisation using photothermal microscopy and their subcellular localisation by electron microscopy. While their uptake increased when the TAT and/or HA2 viral peptides were present on their surface, we did not observe a significant cytosolic delivery of the gold nanoparticles.

  15. 西方制造商售后服务战略研究述评%A Literature Review on After-Sales Strategies for Manufacturers in Western Countries

    Institute of Scientific and Technical Information of China (English)

    张辉

    2012-01-01

    Integrating literatures in marketing management,operation management,and logistics,this paper reviews and discusses the driving forces of an after-sales strategy,after-sales service portfolios design,pricing and distributing after-sales services and corresponding organizational changes bolstering the strategy,in hope that it can guide the manufacturers in China to formulate and implement the strategy.Last,this paper also illuminates the paths leading to future research.%综合营销管理、运营管理和物流管理等多个学科的研究成果,从售后服务战略的动因,售后服务组合设计、定价、渠道、制造商组织变革几个方面对西方现有研究成果进行了回顾和评述,以期对我国制造商售后服务战略的制定与实施有所启示。最后,还对未来研究进行了展望。

  16. Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans.

    Science.gov (United States)

    Zhao, Li; Wit, Janneke; Svetec, Nicolas; Begun, David J

    2015-05-01

    Gene expression variation within species is relatively common, however, the role of natural selection in the maintenance of this variation is poorly understood. Here we investigate low and high latitude populations of Drosophila melanogaster and its sister species, D. simulans, to determine whether the two species show similar patterns of population differentiation, consistent with a role for spatially varying selection in maintaining gene expression variation. We compared at two temperatures the whole male transcriptome of D. melanogaster and D. simulans sampled from Panama City (Panama) and Maine (USA). We observed a significant excess of genes exhibiting differential expression in both species, consistent with parallel adaptation to heterogeneous environments. Moreover, the majority of genes showing parallel expression differentiation showed the same direction of differential expression in the two species and the magnitudes of expression differences between high and low latitude populations were correlated across species, further bolstering the conclusion that parallelism for expression phenotypes results from spatially varying selection. However, the species also exhibited important differences in expression phenotypes. For example, the genomic extent of genotype × environment interaction was much more common in D. melanogaster. Highly differentiated SNPs between low and high latitudes were enriched in the 3' UTRs and CDS of the geographically differently expressed genes in both species, consistent with an important role for cis-acting variants in driving local adaptation for expression-related phenotypes.

  17. The connection between dietary phosphorus, cardiovascular disease, and mortality: where we stand and what we need to know.

    Science.gov (United States)

    Gutiérrez, Orlando M

    2013-11-01

    Disorders of phosphorus metabolism are independent risk factors for cardiovascular disease. Because excess dietary phosphorus intake is common in the general population and plays a central role in disturbances in phosphorus homeostasis, these findings have fueled interest in restricting phosphorus intake as a potential therapy for improving cardiovascular outcomes. Although experimental and observational data support this possibility, current limitations in the assessment of dietary phosphorus consumption in free-living populations and the lack of reliable biomarkers of the effects of dietary phosphorus on cardiovascular health pose major barriers to the design and conduct of trials assessing the efficacy of phosphorus restriction in improving cardiovascular health. Fibroblast growth factor 23 and Klotho are novel mediators of phosphorus metabolism that are tightly linked to dietary phosphorus intake and show promise as integrated biomarkers of phosphorus excess and its long-term health consequences. Advances in the understanding of how these hormones are associated with diet and phosphorus metabolism will likely bolster future efforts to assess the true health consequences of excess phosphorus intake and whether restricting phosphorus intake has salutary effects on cardiovascular health.

  18. Biased evaluation and persistence in gambling.

    Science.gov (United States)

    Gilovich, T

    1983-06-01

    Perhaps the most striking aspect of gambling behavior is that people continue to gamble despite persistent failure. One reason for this persistence may be that gamblers evaluate outcomes in a biased manner. Specifically, gamblers may tend to accept wins at face value but explain away or discount losses. Experiment 1 tested this hypothesis by recording subjects' explanations of the outcomes of their bets on professional football games. The results supported the hypothesis: Subjects spent more time explaining their losses than their wins. A content analysis of these explanations revealed that subjects tended to discount their losses but "bolster" their wins Finally, subjects remembered their losses better during a recall test 3 weeks later. Experiments 2 and 3 extended this analysis by demonstrating that a manipulation of the salience or existence of a critical "fluke" play in a sporting event had a greater impact on the subsequent expectations of those who had bet on the losing team than of those who had bet on the winning team. Both the implications and the possible mechanisms underlying these biases are discussed.

  19. [Influence of voice and hearing changes in the quality of life of active elderly individuals].

    Science.gov (United States)

    Chiossi, Julia Santos Costa; Roque, Francelise Pivetta; Goulart, Bárbara Niegia Garcia de; Chiari, Brasilia Maria

    2014-08-01

    This article seeks to verify the self-rated impact of voice and hearing changes of active elderly individuals in their daily lives, and the influence of this self-rating on quality of life. A cross-sectional study was conducted with 72 elderly individuals of an Open University for Senior Citizens in the state of São Paulo. The questionnaires applied were HHIE-S; VHI and WHOQoL-Old. The Pearson correlation coefficient was used adopting a p-level significance value of life was perceived by 45.8%, and moderate or severe voice handicap by 9.7% of the elderly individuals. The self-rating of hearing impact on daily life was correlated with the voice handicap index. Quality of life was negatively affected by the increase in self-rating of hearing and voice difficulties in daily life. The sample profile is typical of successful aging with the acceptance of aging changes and consequently less impact on daily lives than expected. The findings suggest that there is an impact of voice and hearing handicap on quality of life, although it has revealed high indices, bolstering the characteristic of adaptation of the sample to aging. The results justify the need for improving actions of self-care and empowerment for the elderly.

  20. From road to lab to math: the co-evolution of technological, regulatory, and organizational innovations for automotive crash testing.

    Science.gov (United States)

    Leonardi, Paul M

    2010-04-01

    Today, in the midst of economic crisis, senior executives at US automakers and influential industry analysts frequently reflect on the progression that safety testing has taken from the crude trials done on the road, to controlled laboratory experiments, and to today's complex math-based simulation models. They use stories of this seemingly linear and natural sequence to justify further investment in simulation technologies. The analysis presented in this paper shows that change in the structures of automakers' organizations co-evolved with regulations specifying who was at fault in vehicle impacts, how vehicles should be built to withstand the force of an impact, and how testing should be done to assure that vehicles met those requirements. Changes in the regulatory environment were bolstered by new theories about crash test dynamics and changing technologies with which to test those theories. Thus, as new technological and regulatory innovations co-evolved with innovations in organizational structuring, ideas about how to best conduct crash tests shifted and catalyzed new cycles of technological, regulatory, and organizational innovation. However, this co-evolutionary story tells us that the move from road to lab to math was not natural or linear as today's managerial rhetoric would have us believe. Rather, the logic of math-based simulation was the result of technological, regulatory and organizational changes that created an industry-wide ideology that supported the move toward math while making it appear natural within the shifting structure of the industry.

  1. Effects of terrestrial buffer zones on amphibians on golf courses.

    Directory of Open Access Journals (Sweden)

    Holly J Puglis

    Full Text Available A major cause of amphibian declines worldwide is habitat destruction or alteration. Public green spaces, such as golf courses and parks, could serve as safe havens to curb the effects of habitat loss if managed in ways to bolster local amphibian communities. We reared larval Blanchard's cricket frogs (Acris blanchardi and green frogs (Rana clamitans in golf course ponds with and without 1 m terrestrial buffer zones, and released marked cricket frog metamorphs at the golf course ponds they were reared in. Larval survival of both species was affected by the presence of a buffer zone, with increased survival for cricket frogs and decreased survival for green frogs when reared in ponds with buffer zones. No marked cricket frog juveniles were recovered at any golf course pond in the following year, suggesting that most animals died or migrated. In a separate study, we released cricket frogs in a terrestrial pen and allowed them to choose between mown and unmown grass. Cricket frogs had a greater probability of using unmown versus mown grass. Our results suggest that incorporating buffer zones around ponds can offer suitable habitat for some amphibian species and can improve the quality of the aquatic environment for some sensitive local amphibians.

  2. Effects of terrestrial buffer zones on amphibians on golf courses.

    Science.gov (United States)

    Puglis, Holly J; Boone, Michelle D

    2012-01-01

    A major cause of amphibian declines worldwide is habitat destruction or alteration. Public green spaces, such as golf courses and parks, could serve as safe havens to curb the effects of habitat loss if managed in ways to bolster local amphibian communities. We reared larval Blanchard's cricket frogs (Acris blanchardi) and green frogs (Rana clamitans) in golf course ponds with and without 1 m terrestrial buffer zones, and released marked cricket frog metamorphs at the golf course ponds they were reared in. Larval survival of both species was affected by the presence of a buffer zone, with increased survival for cricket frogs and decreased survival for green frogs when reared in ponds with buffer zones. No marked cricket frog juveniles were recovered at any golf course pond in the following year, suggesting that most animals died or migrated. In a separate study, we released cricket frogs in a terrestrial pen and allowed them to choose between mown and unmown grass. Cricket frogs had a greater probability of using unmown versus mown grass. Our results suggest that incorporating buffer zones around ponds can offer suitable habitat for some amphibian species and can improve the quality of the aquatic environment for some sensitive local amphibians.

  3. Single-Site Zeolite-Anchored Organoiridium Carbonyl Complexes: Characterization of Structure and Reactivity by Spectroscopy and Computational Chemistry.

    Science.gov (United States)

    Martinez-Macias, Claudia; Chen, Mingyang; Dixon, David A; Gates, Bruce C

    2015-08-10

    A family of HY zeolite-supported cationic organoiridium carbonyl complexes was formed by reaction of Ir(CO)2 (acac) (acac=acetylacetonate) to form supported Ir(CO)2 complexes, which were treated at 298 K and 1 atm with flowing gas-phase reactants, including C2 H4 , H2 , (12) CO, (13) CO, and D2 O. Mass spectrometry was used to identify effluent gases, and infrared and X-ray absorption spectroscopies were used to characterize the supported species, with the results bolstered by DFT calculations. Because the support is crystalline and presents a nearly uniform array of bonding sites for the iridium species, these were characterized by a high degree of uniformity, which allowed a precise determination of the species involved in the replacement, for example, of one CO ligand of each Ir(CO)2 complex with ethylene. The supported species include the following: Ir(CO)2 , Ir(CO)(C2 H4)2 , Ir(CO)(C2 H4), Ir(CO)(C2 H5), and (tentatively) Ir(CO)(H). The data determine a reaction network involving all of these species.

  4. Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.

    Science.gov (United States)

    Madan, Babita; Patel, Mehul B; Zhang, Jiandong; Bunte, Ralph M; Rudemiller, Nathan P; Griffiths, Robert; Virshup, David M; Crowley, Steven D

    2016-05-01

    Activated Wnt signaling is critical in the pathogenesis of renal fibrosis, a final common pathway for most forms of chronic kidney disease. Therapeutic intervention by inhibition of individual Wnts or downstream Wnt/β-catenin signaling has been proposed, but these approaches do not interrupt the functions of all Wnts nor block non-canonical Wnt signaling pathways. Alternatively, an orally bioavailable small molecule, Wnt-C59, blocks the catalytic activity of the Wnt-acyl transferase porcupine, and thereby prevents secretion of all Wnt isoforms. We found that inhibiting porcupine dramatically attenuates kidney fibrosis in the murine unilateral ureteral obstruction model. Wnt-C59 treatment similarly blunts collagen mRNA expression in the obstructed kidney. Consistent with its actions to broadly arrest Wnt signaling, porcupine inhibition reduces expression of Wnt target genes and bolsters nuclear exclusion of β-catenin in the kidney following ureteral obstruction. Importantly, prevention of Wnt secretion by Wnt-C59 blunts expression of inflammatory cytokines in the obstructed kidney that otherwise provoke a positive feedback loop of Wnt expression in collagen-producing fibroblasts and epithelial cells. Thus, therapeutic targeting of porcupine abrogates kidney fibrosis not only by overcoming the redundancy of individual Wnt isoforms but also by preventing upstream cytokine-induced Wnt generation. These findings reveal a novel therapeutic maneuver to protect the kidney from fibrosis by interrupting a pathogenic crosstalk loop between locally generated inflammatory cytokines and the Wnt/β-catenin signaling pathway.

  5. Measuring pilot workload in a moving-base simulator. I Asynchronous secondary choice-reaction task

    Science.gov (United States)

    Kantowitz, B. H.; Hart, S. G.; Bortolussi, M. R.

    1983-01-01

    The de facto method for measuring airplane pilot workload is based upon subjective ratings. While researchers agree that such subjective data should be bolstered by using objective behavioral measures, results to date have been mixed. No clear objective technique has surfaced as the metric of choice. It is believed that this difficulty is in part due to neglect of theoretical work in psychology that predicts some of the difficulties that are inherent in a futile search for 'the one and only' best secondary task to measure workload. An initial study that used both subjective ratings and an asynchronous choice-reaction secondary task was conducted to determine if such a secondary task could indeed meet the methodological constraints imposed by current theories of attention. Two variants of a flight scenario were combined with two levels of the secondary task. Appropriate single-task control conditions were also included. Results give grounds for cautious optimism but indicate that future research should use synchronous secondary tasks where possible.

  6. Jordanian Preservice Primary Teachers' Perceptions of Mentoring in Science Teaching

    Science.gov (United States)

    Abed, Osama H.; Abd-El-Khalick, Fouad

    2015-03-01

    Quality mentoring is fundamental to preservice teacher education because of its potential to help student and novice teachers develop the academic and pedagogical knowledge and skills germane to successful induction into the profession. This study focused on Jordanian preservice primary teachers' perceptions of their mentoring experiences as these pertain to science teaching. The Mentoring for Effective Primary Science Teaching instrument was administered to 147 senior preservice primary teachers in a university in Jordan. The results indicated that the greater majority of participants did not experience effective mentoring toward creating a supportive and reflexive environment that would bolster their confidence in teaching science; further their understanding of primary science curriculum, and associated aims and school policies; help with developing their pedagogical knowledge; and/or furnish them with specific and targeted feedback and guidance to help improve their science teaching. Substantially more participants indicated that their mentors modeled what they perceived to be effective science teaching. The study argues for the need for science-specific mentoring for preservice primary teachers, and suggests a possible pathway for achieving such a model starting with those in-service primary teachers-much like those identified by participants in the present study-who are already effective in their science teaching.

  7. Livestock policy and trade issues in SADC.

    Science.gov (United States)

    Hulman, B

    2009-03-01

    As from 2001, the Southern African Development Community (SADC) has embarked on a course to deepen regional integration through restructuring. Under the new structure SADC has centralised the coordination of its activities to the Secretariat in Gaborone. The former Sector Coordinating Units have been merged into four directorates, one of which is the Food, Agriculture and Natural Resources (FANR) Directorate, which comprises, amongst others, the Livestock Development Unit (LDU). The LDU, under the aegis of the FANR, formulates policies for regional livestock development in order to respond to the objectives of the Regional Indicative Strategic Development Plan (RISDP), and which are mainly to: Contribute to improved food security, Promote wealth creation, Enhance rural livelihood, Enhance livestock as a tradable and consumable commodity. Following the launch of the SADC Economic Partnership Agreement (EPA) negotiations, the eight SADC EPA member states identified sanitary and phytosanitary and technical barriers to trade to be major trade barriers for access to international markets, especially the EU market where standards are normally set beyond international standards. SADC has already brought some of the issues related to beef exports to the OIE Regional Commission for Africa as SADC member states feel that a few of the present requirements do not have a scientific basis. The paper discusses the process that the LDU follows in the formulation of policies and strategies in regional livestock development with the objective of bolstering intra and extra regional trade in livestock and livestock products.

  8. Lower Cross-Braced Truck and Swing Motion Truck Have Different Effect on Freight Car Dynamics Performance

    Directory of Open Access Journals (Sweden)

    Chao Chen

    2013-01-01

    Full Text Available There are two major types of trucks for freight car in Chinese railroad. One is the lower cross-braced truck; the other is the swing motion truck. To evaluate the different performance, diamond resistant rigidity of the lower cross-braced truck and the lateral stiffness of the swing motion truck are analyzed. To simulate the dynamics performance of the swing motion truck, an equivalent lateral stiffness is calculated. Then it is modeled as a lateral spring between side frames and bolstered to simulate the swing. After that, two typical freight cars’ models which use the two types of trucks are built in SIMPACK. The L/V Ratio and Wheel Load Reduction Ratio are chosen for evaluating running safety of the freight car. The simulation results are compared and they prove that the impact force between wheel and rail when the car passing curve can be reduced effectively as the swing motion truck has a better lateral flexible. Therefore, it has a lower L/V ratio under the same running and loading condition. However, the swing leads a larger lateral displacement of the car-body, so the gravity center of loaded car has a larger lateral displacement than the car with lower cross-braced truck; which results to a larger Wheel Load Reduction Ratio.  

  9. Estudos da linguagem e mente corporificada: uma nova proposta gramatical Studies of language and embodied mind: a new grammar approach

    Directory of Open Access Journals (Sweden)

    Ricardo Yamashita Santos

    2011-01-01

    Full Text Available Podemos dizer que Descartes fundamentou a filosofia moderna com uma proposta universal do entendimento mundano. Dissociando as experiências corpóreas de nossa matéria pensante - mente, conseguiríamos captar a verdadeira essência de tudo por meio de um pensamento racional e objetivo. A ideia de mente corporificada, traduzida aqui pelos moldes de Lakoff e Johnson (1980, quebra com a dicotomia do filósofo e com diversas outras tradições enraizadas em nossa cultura ocidental. Nosso objetivo neste artigo é o de amparar a nova proposta teórica de mente corporificada e pensar um novo modelo gramatical que evidencie a corporalidade da mente.We can say that Descartes founded the modern philosophy with an universal proposal of the mundane understanding. Dissociating the bodily experience from our thinking matter - mind, we could capture the true essence of everything through rational and objective thought. The idea of the embodied mind, translated here by Lakoff and Johnson's theories (1980, breaks Descartes' dichotomy and various other traditions rooted in our Western culture. Our goals in this paper is to bolster the new theoretical proposition of embodied mind and think about a new grammatical model that highlights the embodiment of mind.

  10. When what you have is who you are: self-uncertainty leads individualists to see themselves in their possessions.

    Science.gov (United States)

    Morrison, Kimberly Rios; Johnson, Camille S

    2011-05-01

    Four studies tested whether uncertainty about the self-concept can motivate people, particularly individualists who define themselves in terms of their personal traits and characteristics, to perceive their material possessions as extensions of themselves (i.e., as self-expressive). In Study 1, European American participants rated their favorite pair of blue jeans as more self-expressive after being induced to feel self-uncertain, whereas Asian American participants did not. In Study 2, participants who scored high on a measure of individualism rated their cars as more self-expressive following a self-uncertainty manipulation. In Study 3, individualists (but not collectivists) rated their favorite possessions as more self-expressive after being subject to self-uncertainty; a manipulation of self-irrelevant uncertainty did not produce these results. In Study 4, thinking about a self-expressive (relative to utilitarian) possession bolstered self-certainty among individualists, but not collectivists. Implications for research on culture, the self-concept, and possessions are discussed.

  11. A Dynamic Community of Discovery: Planning, Learning, and Change

    Directory of Open Access Journals (Sweden)

    Michelle Gordon

    2011-01-01

    Full Text Available Ryerson University’s Prior Learning and Competency Evaluation and Documentation (PLACED program is funded by the Government of Ontario to engage internationally educated professionals (IEPs, employers, and regulatory/occupational bodies in the use of competency-based practices. In 2008, the authors created a self-assessment tool for IEPs that would build a portfolio reflecting an individual’s knowledge and skills while introducing him or her to aspects of the Canadian workplace and labour market. The authors felt that this tool would be useful to assist IEPs in considering their career options and wanted to create an online workshop that would provide flexibility to users whose priorities were most likely work and family obligations. This short project description will capture a why the self-assessment tool was developed; (b how we fostered participants’ self-efficacy; c how we used Blackboard; (d what the participants gained from the workshop; and (e how the workshop has evolved based on facilitators’ observations, participants’ feedback, and an external organization’s request for customizing the workshop. In working together to design the online workshop, IEPs’ Self-Assessment and Planning, we focused on two main concepts: self-assessment and career planning. With that in mind, we set out in the workshop to bolster self-discovery, self-efficacy, individualized research skills, action planning, and ongoing professional development. The learning platform was Blackboard, which is used across Ryerson University in both classroom and online learning.

  12. Influence of MnO2 decorated Fe nano cauliflowers on microwave absorption and impedance matching of polyvinylbutyral (PVB) matrix

    Science.gov (United States)

    Bora, Pritom J.; Porwal, Mayuri; Vinoy, K. J.; Ramamurthy, Praveen C.; Madras, Giridhar

    2016-09-01

    In this work, a promising, polyvinyl butryl (PVB)-MnO2 decorated Fe composite was synthesised and microwave absorption properties were studied for the most important frequency ranges i.e., X-band (8.2-12.4 GHz) and Ku-band (12.4-18 GHz). The microwave absorption of Fe nano cauliflower structure can be enhanced by MnO2 nanofiber coating. 10 wt% Fe-MnO2 nano cauliflower loaded PVB composite films (2 mm thick) shows an appreciable increase in microwave absorption properties. In X-band, the reflection loss (RL) of this composite decreases almost linearly to -7.5 dB, whereas in the Ku-band the minimum RL was found to be -15.7 dB at 14.7 GHz. Here it was observed that impedance matching is the primarily important factor responsible for enhanced microwave absorption. Further, enhancement of EM attenuation constant (α), dielectrics, scattering attenuation also bolsters the obtained results. This polymer composite can be considered as a novel microwave absorbing coating material.

  13. “Recovering our Stories”: A Small Act of Resistance

    Directory of Open Access Journals (Sweden)

    Lucy Costa

    2012-10-01

    Full Text Available This paper describes a community event organized in response to the appropriation and overreliance on the psychiatric patient “personal story” within mental health organizations. The sharing of experiences through stories by individuals who self-identify as having “lived experience” has been central to the history of organizing for change in and outside of the psychiatric system. However, in the last decade, personal stories have increasingly been used by the psychiatric system to bolster research, education, and fundraising interests. We explore how personal stories from consumer/survivors have been harnessed by mental health organizations to further their interests and in so doing have shifted these narrations from “agents of change” towards one of “disability tourism” or “patient porn.” We mark the ethical dilemmas of narrative cooptation and consumption, and query how stories of resistance can be reclaimed not as personal recovery narratives but rather as a tool for socio-political change.

  14. Stabilization of memory States by stochastic facilitating synapses.

    Science.gov (United States)

    Miller, Paul

    2013-12-06

    Bistability within a small neural circuit can arise through an appropriate strength of excitatory recurrent feedback. The stability of a state of neural activity, measured by the mean dwelling time before a noise-induced transition to another state, depends on the neural firing-rate curves, the net strength of excitatory feedback, the statistics of spike times, and increases exponentially with the number of equivalent neurons in the circuit. Here, we show that such stability is greatly enhanced by synaptic facilitation and reduced by synaptic depression. We take into account the alteration in times of synaptic vesicle release, by calculating distributions of inter-release intervals of a synapse, which differ from the distribution of its incoming interspike intervals when the synapse is dynamic. In particular, release intervals produced by a Poisson spike train have a coefficient of variation greater than one when synapses are probabilistic and facilitating, whereas the coefficient of variation is less than one when synapses are depressing. However, in spite of the increased variability in postsynaptic input produced by facilitating synapses, their dominant effect is reduced synaptic efficacy at low input rates compared to high rates, which increases the curvature of neural input-output functions, leading to wider regions of bistability in parameter space and enhanced lifetimes of memory states. Our results are based on analytic methods with approximate formulae and bolstered by simulations of both Poisson processes and of circuits of noisy spiking model neurons.

  15. System-Level Testing of the Advanced Stirling Radioisotope Generator Engineering Hardware

    Science.gov (United States)

    Chan, Jack; Wiser, Jack; Brown, Greg; Florin, Dominic; Oriti, Salvatore M.

    2014-01-01

    To support future NASA deep space missions, a radioisotope power system utilizing Stirling power conversion technology was under development. This development effort was performed under the joint sponsorship of the Department of Energy and NASA, until its termination at the end of 2013 due to budget constraints. The higher conversion efficiency of the Stirling cycle compared with that of the Radioisotope Thermoelectric Generators (RTGs) used in previous missions (Viking, Pioneer, Voyager, Galileo, Ulysses, Cassini, Pluto New Horizons and Mars Science Laboratory) offers the advantage of a four-fold reduction in Pu-238 fuel, thereby extending its limited domestic supply. As part of closeout activities, system-level testing of flight-like Advanced Stirling Convertors (ASCs) with a flight-like ASC Controller Unit (ACU) was performed in February 2014. This hardware is the most representative of the flight design tested to date. The test fully demonstrates the following ACU and system functionality: system startup; ASC control and operation at nominal and worst-case operating conditions; power rectification; DC output power management throughout nominal and out-of-range host voltage levels; ACU fault management, and system command / telemetry via MIL-STD 1553 bus. This testing shows the viability of such a system for future deep space missions and bolsters confidence in the maturity of the flight design.

  16. Atacama Cosmology Telescope: Extragalactic Sources at 148 GHz in the 2008 Survey

    CERN Document Server

    Marriage, T A; Lin, Y -T; Marsden, D; Nolta, M R; Partridge, B; Ade, P A R; Aguirre, P; Amiri, M; Appel, J W; Barrientos, L F; Battistelli, E S; Bond, J R; Brown, B; Burger, B; Chervenak, J; Das, S; Devlin, M J; Dicker, S R; Doriese, W B; Dunkley, J; Dunner, R; Essinger-Hileman, T; Fisher, R P; Fowler, J W; Hajian, A; Halpern, M; Hasselfield, M; Hernandez-Monteagudo, C; Hilton, G C; Hilton, M; Hincks, A D; Hlozek, R; Huffenberger, K M; Hughes, D H; Hughes, J P; Infante, L; Irwin, K D; Kaul, M; Klein, J; Kosowsky, A; Lau, J M; Limon, M; Lupton, R H; Martocci, K; Mauskopf, P; Menanteau, F; Moodley, K; Moseley, H; Netterfield, C B; Niemack, M D; Page, L A; Parker, L; Quintana, H; Reid, B; Sehgal, N; Sherwin, B D; Sievers, J; Spergel, D N; Staggs, S T; Swetz, D S; Switzer, E R; Thornton, R; Trac, H; Tucker, C; Warne, R; Wilson, G; Wollack, E; Zhao, Y

    2010-01-01

    We report on extragalactic sources detected in a 455 square-degree map of the southern sky made with data at a frequency of 148 GHz from the Atacama Cosmology Telescope 2008 observing season. We provide a catalog of 157 sources with flux densities spanning two orders of magnitude: from 15 to 1500 mJy. Comparison to other catalogs shows that 98% of the ACT detections correspond to sources detected at lower radio frequencies. Three of the sources appear to be associated with the brightest cluster galaxies of low redshift X-ray selected galaxy clusters. Estimates of the radio to mm-wave spectral indices and differential counts of the sources further bolster the hypothesis that they are nearly all radio sources, and that their emission is not dominated by re-emission from warm dust. In a bright (>50 mJy) 148 GHz-selected sample with complete cross-identifications from the Australia Telescope 20 GHz survey, we observe an average steepening of the spectra between 5, 20, and 148 GHz with median spectral indices of $...

  17. In Search of the jüdische Typus: A Proposed Benchmark to Test the Genetic Basis of Jewishness Challenges Notions of “Jewish Biomarkers”

    Science.gov (United States)

    Elhaik, Eran

    2016-01-01

    The debate as to whether Jewishness is a biological trait inherent from an “authentic” “Jewish type” (jüdische Typus) ancestor or a system of beliefs has been raging for over two centuries. While the accumulated biological and anthropological evidence support the latter argument, recent genetic findings, bolstered by the direct-to-consumer genetic industry, purport to identify Jews or quantify one’s Jewishness from genomic data. To test the merit of claims that Jews and non-Jews are genetically distinguishable, we propose a benchmark where genomic data of Jews and non-Jews are hybridized over two generations and the observed and predicted Jewishness of the terminal offspring according to either the Orthodox religious law (Halacha) or the Israeli Law of Return are compared. Members of academia, the public, and 23andMe were invited to use the benchmark to test claims that Jews are genetically distinct from non-Jews. Here, we report the findings from these trials. We also compare the genomic similarity of ∼300 individuals from nearly thirty Afro-Eurasian Jewish communities to a simulated jüdische Typus population. The results are discussed in light of modern trends in the genetics of Jews and related fields and provide a tentative answer to the ageless question “who is a Jew?” PMID:27547215

  18. A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid.

    Science.gov (United States)

    Whitlock, Jarred M; Hartzell, H Criss

    2016-03-01

    Since their first descriptions, ion channels have been conceived as proteinaceous conduits that facilitate the passage of ionic cargo between segregated environments. This concept is reinforced by crystallographic structures of cation channels depicting ion conductance pathways completely lined by protein. Although lipids are sometimes present in fenestrations near the pore or may be involved in channel gating, there is little or no evidence that lipids inhabit the ion conduction pathway. Indeed, the presence of lipid acyl chains in the conductance pathway would curse the design of the channel's aqueous pore. Here, we make a speculative proposal that anion channels in the TMEM16/ANO superfamily have ion conductance pathways composed partly of lipids. Our reasoning is based on the idea that TMEM16 ion channels evolved from a kind of lipid transporter that scrambles lipids between leaflets of the membrane bilayer and the modeled structural similarity between TMEM16 lipid scramblases and TMEM16 anion channels. This novel view of the TMEM16 pore offers explanation for the biophysical and pharmacological oddness of TMEM16A. We build upon the recent X-ray structure of nhTMEM16 and develop models of both TMEM16 ion channels and lipid scramblases to bolster our proposal. It is our hope that this model of the TMEM16 pore will foster innovative investigation into TMEM16 function.

  19. Human embryonic stem cell therapies for neurodegenerative diseases.

    Science.gov (United States)

    Tomaskovic-Crook, Eva; Crook, Jeremy M

    2011-06-01

    There is a renewed enthusiasm for the clinical translation of human embryonic stem (hES) cells. This is abetted by putative clinically-compliant strategies for hES cell maintenance and directed differentiation, greater understanding of and accessibility to cells through formal cell registries and centralized cell banking for distribution, the revised US government policy on funding hES cell research, and paradoxically the discovery of induced pluripotent stem (iPS) cells. Additionally, as we consider the constraints (practical and fiscal) of delivering cell therapies for global healthcare, the more efficient and economical application of allogeneic vs autologous treatments will bolster the clinical entry of hES cell derivatives. Neurodegenerative disorders such as Parkinson's disease are primary candidates for hES cell therapy, although there are significant hurdles to be overcome. The present review considers key advances and challenges to translating hES cells into novel therapies for neurodegenerative diseases, with special consideration given to Parkinson's disease and Alzheimer's disease. Importantly, despite the focus on degenerative brain disorders and hES cells, many of the issues canvassed by this review are relevant to systemic application of hES cells and other pluripotent stem cells such as iPS cells.

  20. Green shopping

    DEFF Research Database (Denmark)

    Thøgersen, John

    2011-01-01

    Findings suggesting that consumers buy “green” products, such as organic foods, for selfish reasons are usually accepted at face value. In this article, the author argues that the evidence backing this claim is questionable and that it reflects post hoc rationalizations and self-presentation bias...... at least start to buy these products for unselfish reasons (the common good). However, after having done so, they seem to bolster their beliefs about private benefits to preserve a self-image of being a competent and rational person.......Findings suggesting that consumers buy “green” products, such as organic foods, for selfish reasons are usually accepted at face value. In this article, the author argues that the evidence backing this claim is questionable and that it reflects post hoc rationalizations and self-presentation biases...... on behalf of respondents. Knowing that one has incurred substantial personal costs by contributing to a worthy cause can create an uneasiness that one is motivated to relieve, especially when one is uncertain about the ultimate impact of this contribution. A possible coping strategy is to adjust one...

  1. A Review of the Water and Energy Sectors and the Use of a Nexus Approach in Abu Dhabi.

    Science.gov (United States)

    Paul, Parneet; Al Tenaiji, Ameena Kulaib; Braimah, Nuhu

    2016-03-25

    Rapid population increase coupled with urbanization and industrialization has resulted in shortages of water in the Middle East. This situation is further exacerbated by global climate change due to greenhouse gas emissions. Recent research advocates that solutions to the global water security and scarcity crisis must involve water-energy nexus approaches. This means adopting policies and strategies that harmonize these inter-related sectors to minimize environmental impact while maximizing human benefit. In the case of Abu Dhabi, when designing and locating oil/gas refineries and associated power generation facilities, previous relevant decisions were based on simple economic and geographical grounds, such as nearness to oil rigs, pipelines, existing industries and port facilities, etc. The subsequent design and location of water abstraction and treatment works operated by the waste heat from these refining and/or power generation processes was catered for as an afterthought, meaning that there is now a mismatch between the water and energy supplies and demands. This review study was carried out to show how Abu Dhabi is trying now to integrate its water-energy sectors using a nexus approach so that future water/power infrastructure is designed optimally and operated in harmony, especially in regard to future demand. Based upon this review work, some recommendations are made for designers and policy makers alike to bolster the nexus approach that Abu Dhabi is pursuing.

  2. Regulatory T Cells in Colorectal Cancer: From Biology to Prognostic Relevance

    Directory of Open Access Journals (Sweden)

    Dimitrios Mougiakakos

    2011-03-01

    Full Text Available Regulatory T cells (Tregs were initially described as "suppressive" lymphocytes in the 1980s. However, it took almost 20 years until the concept of Treg-mediated immune control in its present form was finally established. Tregs are obligatory for self-tolerance and defects within their population lead to severe autoimmune disorders. On the other hand Tregs may promote tolerance for tumor antigens and even hamper efforts to overcome it. Intratumoral and systemic accumulation of Tregs has been observed in various types of cancer and is often linked to worse disease course and outcome. Increase of circulating Tregs, as well as their presence in mesenteric lymph nodes and tumor tissue of patients with colorectal cancer de facto suggests a strong involvement of Tregs in the antitumor control. This review will focus on the Treg biology in view of colorectal cancer, means of Treg accumulation and the controversies regarding their prognostic significance. In addition, a concise overview will be given on how Tregs and their function can be targeted in cancer patients in order to bolster an inherent immune response and/or increase the efficacy of immunotherapeutic approaches.

  3. Dinosaur Peptides Suggest Mechanisms of Protein Survival

    Energy Technology Data Exchange (ETDEWEB)

    San Antonio, James D.; Schweitzer, Mary H.; Jensen, Shane T.; Kalluri, Raghu; Buckley, Michael; Orgel, Joseph P.R.O. (Harvard-Med); (IIT); (NCSU); (UPENN); (Manchester); (Orthovita)

    2011-09-16

    Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected by the close packing of collagen molecules, and contained few acidic amino acids. Four peptides mapped to collagen regions crucial for cell-collagen interactions and tissue development. Dinosaur peptides were not represented in more exposed parts of the collagen fibril or regions mediating intermolecular cross-linking. Thus functionally significant regions of collagen fibrils that are physically shielded within the fibril may be preferentially preserved in fossils. These results show empirically that structure-function relationships at the molecular level could contribute to selective preservation in fossilized vertebrate remains across geological time, suggest a 'preservation motif', and bolster current concepts linking collagen structure to biological function. This non-random distribution supports the hypothesis that the peptides are produced by the extinct organisms and suggests a chemical mechanism for survival.

  4. Genetic Variability and Phylogenetic Relationships within Trypanosoma cruzi I Isolated in Colombia Based on Miniexon Gene Sequences

    Directory of Open Access Journals (Sweden)

    Claudia Herrera

    2009-01-01

    Full Text Available Phylogenetic studies of Trypanosoma cruzi have identified the existence of two groups: T. cruzi I and T. cruzi II. There are aspects that still remain unknown about the genetic variability within the T. cruzi I group. Given its epidemiological importance, it is necessary to have a better understanding of T. cruzi transmission cycles. Our purpose was to corroborate the existence of haplotypes within the T. cruzi I group and to describe the genetic variability and phylogenetic relationships, based on single nucleotide polymorphisms (SNPs found in the miniexon gene intergenic region, for the isolates from different hosts and epidemiological transmission cycles in Colombian regions. 31 T. cruzi isolates were molecularly characterized. Phylogenetic relationships within T. cruzi I isolates showed four haplotype groups (Ia–Id, associated with their transmission cycle. In previous studies, we reported that haplotype Ia is mainly associated with the domestic cycle and domiciliated Rhodnius prolixus. Haplotype Ib is associated with the domestic cycle and peridomestic cycle, haplotype Ic is closely related with the peridomestic cycle, and haplotype Id is strongly associated with the sylvatic cycle. The phylogenetic methodologies applied in this study are tools that bolster the associations among isolates and thus shed light on Chagas disease epidemiology.

  5. Scientific Legitimation of the European Union’s Competence Development Policy

    Directory of Open Access Journals (Sweden)

    Rosario Sergio Maniscalco

    2012-01-01

    Full Text Available This study provides an accessible account of the policy making process of the European Union in the arena of adult skills and competence development. In particular, the way skill standards for adult learners is designed in the EU official statements is investigated, analyzing the developments in the European Union’s adult education policies since the Lisbon process was launched in order to verify to what extent they are evidence-based and legitimated through scientific research and specific ex-ante studies. In fact, because of the ageing work force in Europe, but also in the light of the recent economic downturns and the increased labor market’s flexibility and dynamics, many governments have tried to foster the involvement and participation of adults in lifelong learning paths for them to suit the transformations of the knowledge-based societies and be active and competitive even in older ages. This empirical paper is based on literature review and content analysis of the relevant policy documents and official EU statements. The main findings show how, beyond declared purposes and political slogans, the way the EU is shaping the adult learners’ upskilling significantly appears to aim at the substantial bolstering of basic and digital skills in order to cope with the knowledge economy rather than giving emphasis to more comprehensive sets of competences for lifelong learning and active ageing, which are going to be needed more than ever in the years to come.

  6. Large-Scale Evaluation of Association Between Pheromone Trap Captures and Cotton Boll Infestation for Pink Bollworm (Lepidoptera: Gelechiidae).

    Science.gov (United States)

    Carrière, Yves; Antilla, Larry; Liesner, Leighton; Tabashnik, Bruce E

    2017-03-16

    Although transgenic cotton producing insecticidal proteins from Bacillus thuringiensis (Bt) is a cornerstone for pink bollworm control in some countries, integrated pest management remains important for bolstering sustainability of Bt cotton and is critical for controlling pink bollworm where Bt cotton is not available or where this pest has evolved resistance to Bt cotton. Here, we used data on moth captures in gossyplure-baited pheromone traps and boll infestations for 163 Bt and 152 non-Bt cotton fields from Arizona to evaluate accuracy of chemical control decisions relying on moth trapping data and capacity of Bt cotton to suppress survival of offspring produced by moths. Assuming an economic injury level of 12% boll infestation, the accuracy of decisions based on moth captures corresponding to economic thresholds of 6%, 8%, and 10% boll infestation increased from 44.7% to 67.1%. The association between moth captures and boll infestation was positive and significant for non-Bt cotton fields but was not significant for Bt cotton fields. Although chemical control decisions based on trapping data were only moderately accurate, pheromone traps could still be valuable for determining when moth populations are high enough to trigger boll sampling to more rigorously evaluate the need for insecticide sprays.

  7. The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

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    S. Michal eJazwinski

    2012-05-01

    Full Text Available Mitochondrial dysfunction activates intracellular signaling pathways that impact yeast longevity, and the best known of these pathways is the retrograde response. More recently, similar responses have been discerned in other systems, from invertebrates to human cells. However, the identity of the signal transducers is either unknown or apparently diverse, contrasting with the well-established signaling module of the yeast retrograde response. On the other hand, it has become equally clear that several other pathways and processes interact with the retrograde response, embedding it in a network responsive to a variety of cellular states. An examination of this network supports the notion that the master regulator NFkB aggregated a variety of mitochondria-related cellular responses at some point in evolution and has become the retrograde transcription factor. This has significant consequences for how we view some of the deficits associated with aging, such as inflammation. The support for NFkB as the retrograde response transcription factor is not only based on functional analyses. It is bolstered by the fact that NFkB can regulate Myc-Max, which is activated in human cells with dysfunctional mitochondria and impacts cellular metabolism. Myc-Max is homologous to the yeast retrograde response transcription factor Rtg1-Rtg3. Further research will be needed to disentangle the pro-aging from the anti-aging effects of NFkB. Interestingly, this is also a challenge for the complete understanding of the yeast retrograde response.

  8. Critical Consciousness and Schooling: The Impact of the Community as a Classroom Program on Academic Indicators

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    D. Gavin Luter

    2017-02-01

    Full Text Available The present study investigates the extent to which a program guided by the principles of critical pedagogy, which seeks to develop critical consciousness, is associated with the improved academic performance of students attending a low-performance middle-school in Buffalo, New York. The students were enrolled in an in-school academic support program called the Community as Classroom, which used critical project-based learning to show students how to improve neighborhood conditions. The study found that the Community as Classroom program bolstered student engagement as reflected in improved attendance, on-time-arrival at school, and reduced suspensions. Although class grades did not improve, standardized scores, particularly in Math and Science, dramatically improved for these students from the lowest scoring categories. We suspect that given increased student engagement and dramatically improved standardized test scores, teacher bias might be the cause of no improvements in class grades. We conclude that critical pedagogy, which leads to increased critical consciousness, is a tool that can lead to improved academic performance of students. Such a pedagogy, we argue, should be more widely used in public schools, with a particular emphasis on their deployment in Community Schools.

  9. Peru Water Resources: Integrating NASA Earth Observations into Water Resource Planning and Management in Perus La Libertad Region

    Science.gov (United States)

    Padgett-Vasquez, Steve; Steentofte, Catherine; Holbrook, Abigail

    2014-01-01

    Developing countries often struggle with providing water security and sanitation services to their populations. An important aspect of improving security and sanitation is developing a comprehensive understanding of the country's water budget. Water For People, a non-profit organization dedicated to providing clean drinking water, is working with the Peruvian government to develop a water budget for the La Libertad region of Peru which includes the creation of an extensive watershed management plan. Currently, the data archive of the necessary variables to create the water management plan is extremely limited. Implementing NASA Earth observations has bolstered the dataset being used by Water For People, and the METRIC (Mapping EvapoTranspiration at High Resolution and Internalized Calibration) model has allowed for the estimation of the evapotranspiration values for the region. Landsat 8 imagery and the DEM (Digital Elevation Model) from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) sensor onboard Terra were used to derive the land cover information, and were used in conjunction with local weather data of Cascas from Peru's National Meteorological and Hydrological Service (SENAMHI). Python was used to combine input variables and METRIC model calculations to approximate the evapotranspiration values for the Ochape sub-basin of the Chicama River watershed. Once calculated, the evapotranspiration values and methodology were shared Water For People to help supplement their decision support tools in the La Libertad region of Peru and potentially apply the methodology in other areas of need.

  10. Hand-rearing, release and survival of African penguin chicks abandoned before independence by moulting parents.

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    Richard B Sherley

    Full Text Available The African penguin Spheniscus demersus has an 'Endangered' conservation status and a decreasing population. Following abandonment, 841 African penguin chicks in 2006 and 481 in 2007 were admitted to SANCCOB (Southern African Foundation for the Conservation of Coastal Birds for hand-rearing from colonies in the Western Cape, South Africa, after large numbers of breeding adults commenced moult with chicks still in the nest. Of those admitted, 91% and 73% respectively were released into the wild. There were veterinary concerns about avian malaria, airsacculitis and pneumonia, feather-loss and pododermatitis (bumblefoot. Post-release juvenile (0.32, s.e.  = 0.08 and adult (0.76, s.e.  = 0.10 survival rates were similar to African penguin chicks reared after oil spills and to recent survival rates recorded for naturally-reared birds. By December 2012, 12 birds had bred, six at their colony of origin, and the apparent recruitment rate was 0.11 (s.e.  = 0.03. Hand-rearing of abandoned penguin chicks is recommended as a conservation tool to limit mortality and to bolster the population at specific colonies. The feasibility of conservation translocations for the creation of new colonies for this species using hand-reared chicks warrants investigation. Any such programme would be predicated on adequate disease surveillance programmes established to minimise the risk of disease introduction to wild birds.

  11. search.bioPreprint: a discovery tool for cutting edge, preprint biomedical research articles [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Carrie L. Iwema

    2016-07-01

    Full Text Available The time it takes for a completed manuscript to be published traditionally can be extremely lengthy. Article publication delay, which occurs in part due to constraints associated with peer review, can prevent the timely dissemination of critical and actionable data associated with new information on rare diseases or developing health concerns such as Zika virus. Preprint servers are open access online repositories housing preprint research articles that enable authors (1 to make their research immediately and freely available and (2 to receive commentary and peer review prior to journal submission. There is a growing movement of preprint advocates aiming to change the current journal publication and peer review system, proposing that preprints catalyze biomedical discovery, support career advancement, and improve scientific communication. While the number of articles submitted to and hosted by preprint servers are gradually increasing, there has been no simple way to identify biomedical research published in a preprint format, as they are not typically indexed and are only discoverable by directly searching the specific preprint server websites. To address this issue, we created a search engine that quickly compiles preprints from disparate host repositories and provides a one-stop search solution. Additionally, we developed a web application that bolsters the discovery of preprints by enabling each and every word or phrase appearing on any web site to be integrated with articles from preprint servers. This tool, search.bioPreprint, is publicly available at http://www.hsls.pitt.edu/resources/preprint.

  12. For telehealth to succeed, privacy and security risks must be identified and addressed.

    Science.gov (United States)

    Hall, Joseph L; McGraw, Deven

    2014-02-01

    The success of telehealth could be undermined if serious privacy and security risks are not addressed. For example, sensors that are located in a patient's home or that interface with the patient's body to detect safety issues or medical emergencies may inadvertently transmit sensitive information about household activities. Similarly, routine data transmissions from an app or medical device, such as an insulin pump, may be shared with third-party advertisers. Without adequate security and privacy protections for underlying telehealth data and systems, providers and patients will lack trust in the use of telehealth solutions. Although some federal and state guidelines for telehealth security and privacy have been established, many gaps remain. No federal agency currently has authority to enact privacy and security requirements to cover the telehealth ecosystem. This article examines privacy risks and security threats to telehealth applications and summarizes the extent to which technical controls and federal law adequately address these risks. We argue for a comprehensive federal regulatory framework for telehealth, developed and enforced by a single federal entity, the Federal Trade Commission, to bolster trust and fully realize the benefits of telehealth.

  13. Towards Teaching Chemistry as a Language

    Science.gov (United States)

    Laszlo, Pierre

    2013-07-01

    This paper presents views on the teaching of chemistry and directions for its further development. A detailed critical analysis is offered for the inadequacy of much of the current teaching, weighed that it is by a conventional, traditional and, as it turns out, rather outdated sense of the material to be covered. The ambient meta-discourse on the nature of chemistry is unduly dominated by the physicalist assumption, believing chemistry to be reducible to physics, which I hold to be unrefutable and thus parascientific. This all-too-tenuous link is countered with a parallel, bolstered by a slew of examples and analogies, between chemistry and linguistics: it is both more legitimate, in terms of the supporting evidence, considerably more effective than a physicalist approach. Chemical teaching needs to hybridize the bottom-up and the top-down communication vectors between the students and their teacher. It can only benefit from infusion of a strong dose of history. Chemistry ought to be taught in like manner to a language, on the dual evidence of the existence of an iconic chemical language, of formulas and equations; and of chemical science being language-like and a combinatorial art.

  14. Current ADC Linker Chemistry.

    Science.gov (United States)

    Jain, Nareshkumar; Smith, Sean W; Ghone, Sanjeevani; Tomczuk, Bruce

    2015-11-01

    The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures. Of the 34 disclosed structures, 24 of them use a linkage to the thiol of cysteines on the monoclonal antibody. The remaining 10 candidates utilize chemistry to surface lysines of the antibody. Due to the inherent heterogeneity of conjugation to the multiple lysines or cysteines found in mAbs, significant research efforts are now being directed toward the production of discrete, homogeneous ADC products, via site-specific conjugation. These site-specific conjugations may involve genetic engineering of the mAb to introduce discrete, available cysteines or non-natural amino acids with an orthogonally-reactive functional group handle such as an aldehyde, ketone, azido, or alkynyl tag. These site-specific approaches not only increase the homogeneity of ADCs but also enable novel bio-orthogonal chemistries that utilize reactive moieties other than thiol or amine. This broadens the diversity of linkers that can be utilized which will lead to better linker design in future generations of ADCs.

  15. Alcohol discrimination and preferences in two species of nectar-feeding primate

    Science.gov (United States)

    Brown, Michael B.; Dominy, Nathaniel J.

    2016-01-01

    Recent reports suggest that dietary ethanol, or alcohol, is a supplemental source of calories for some primates. For example, slow lorises (Nycticebus coucang) consume fermented nectars with a mean alcohol concentration of 0.6% (range: 0.0–3.8%). A similar behaviour is hypothesized for aye-ayes (Daubentonia madagascariensis) based on a single point mutation (A294V) in the gene that encodes alcohol dehydrogenase class IV (ADH4), the first enzyme to catabolize alcohol during digestion. The mutation increases catalytic efficiency 40-fold and may confer a selective advantage to aye-ayes that consume the nectar of Ravenala madagascariensis. It is uncertain, however, whether alcohol exists in this nectar or whether alcohol is preferred or merely tolerated by nectarivorous primates. Here, we report the results of a multiple-choice food preference experiment with two aye-ayes and a slow loris. We conducted observer-blind trials with randomized, serial dilutions of ethanol (0–5%) in a standard array of nectar-simulating sucrose solutions. We found that both species can discriminate varying concentrations of alcohol; and further, that both species prefer the highest available concentrations. These results bolster the hypothesized adaptive function of the A294V mutation in ADH4, and a connection with fermented foods, both in aye-ayes and the last common ancestor of African apes and humans. PMID:27493777

  16. Implementing Qualitative Data Management Plans to Ensure Ethical Standards in Multi-Partner Centers.

    Science.gov (United States)

    Hardy, Lisa J; Hughes, Amy; Hulen, Elizabeth; Schwartz, Anna L

    2016-04-01

    Thorough data management is crucial for the protection of people who participate in research and the ability for researchers to share results with the public. The impact of inadequate adherence to data management is particularly evident in small field sites and among vulnerable populations partoicipating in Community-Based Participatory Research (CBPR). CBPR presents exciting opportunities for multimedia and multi-sectoral dissemination of research results and policy change, especially concerning the impact of research on health equity for underrepresented populations. In this article, we discuss how we defined data boundaries and protections to adhere to ethical standards while also prioritizing data dissemination while using CBPR with American Indians in Arizona. Although complex partnerships can introduce additional risks to data oversight, data management practices can also increase opportunities for wide-reaching dissemination. We hope to contribute to the literature on data sharing in multi-partnership projects to bolster the impact of dissemination while also protecting participants and populations who chose to collaborate in research and policy practices.

  17. Migration selection, protection, and acculturation in health: a binational perspective on older adults.

    Science.gov (United States)

    Riosmena, Fernando; Wong, Rebeca; Palloni, Alberto

    2013-06-01

    In this article, we test for four potential explanations of the Hispanic Health Paradox (HHP): the "salmon bias," emigration selection, and sociocultural protection originating in either destination or sending country. To reduce biases related to attrition by return migration typical of most U.S.-based surveys, we combine data from the Mexican Health and Aging Study in Mexico and the U.S. National Health Interview Survey to compare self-reported diabetes, hypertension, current smoking, obesity, and self-rated health among Mexican-born men ages 50 and older according to their previous U.S. migration experience, and U.S.-born Mexican Americans and non-Hispanic whites. We also use height, a measure of health during childhood, to bolster some of our tests. We find an immigrant advantage relative to non-Hispanic whites in hypertension and, to a lesser extent, obesity. We find evidence consistent with emigration selection and the salmon bias in height, hypertension, and self-rated health among immigrants with less than 15 years of experience in the United States; we do not find conclusive evidence consistent with sociocultural protection mechanisms. Finally, we illustrate that although ignoring return migrants when testing for the HHP and its mechanisms, as well as for the association between U.S. experience and health, exaggerates these associations, they are not fully driven by return migration-related attrition.

  18. Magnetohydrodynamic Fast Shocks and Their Relation to Solar Energetic Particle Event Intensities

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    Kan Liou

    2013-01-01

    Full Text Available Gradual solar energetic particles (SEPs are associated with interplanetary (IP shock driven by coronal mass ejections. Testing theories/models that are built around shock acceleration mechanisms is difficult due to the complexity of SEP fluxes acquired by single-point measurements. To circumvent this, we correlate fast-forward shock Mach numbers derived from a 1.5D magnetohydrodynamics simulation with the intensity of solar energetic oxygen (O and helium-4 (4He particles acquired by instruments aboard the ACE spacecraft during a series of coronal mass ejections in 2003 (October 28 - 31. A good correlation at the 5% significance level is found for O and 4He with energy (E > ~10 MeV n-1, with the peak correlation coefficient r = 0.82 for O (E = 63.8 - 89.8 MeV n-1 and r = 0.77 for 4He (E = 18.0 - 29.4 MeV n-1, respectively, for hourly averaged data. This result not only bolsters the causal relationship between IP fast shocks and SEPs, but also suggests that the Mach number of IP shocks is one of the major controlling parameters for the intensity of SEPs measured in the near-Earth space.

  19. Win-win for wind and wildlife: a vision to facilitate sustainable development.

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    Joseph M Kiesecker

    Full Text Available Wind energy offers the potential to reduce carbon emissions while increasing energy independence and bolstering economic development. However, wind energy has a larger land footprint per Gigawatt (GW than most other forms of energy production, making appropriate siting and mitigation particularly important. Species that require large unfragmented habitats and those known to avoid vertical structures are particularly at risk from wind development. Developing energy on disturbed lands rather than placing new developments within large and intact habitats would reduce cumulative impacts to wildlife. The U.S. Department of Energy estimates that it will take 241 GW of terrestrial based wind development on approximately 5 million hectares to reach 20% electricity production for the U.S. by 2030. We estimate there are ∼7,700 GW of potential wind energy available across the U.S., with ∼3,500 GW on disturbed lands. In addition, a disturbance-focused development strategy would avert the development of ∼2.3 million hectares of undisturbed lands while generating the same amount of energy as development based solely on maximizing wind potential. Wind subsidies targeted at favoring low-impact developments and creating avoidance and mitigation requirements that raise the costs for projects impacting sensitive lands could improve public value for both wind energy and biodiversity conservation.

  20. Win-Win for Wind and Wildlife: A Vision to Facilitate Sustainable Development

    Science.gov (United States)

    Kiesecker, Joseph M.; Evans, Jeffrey S.; Fargione, Joe; Doherty, Kevin; Foresman, Kerry R.; Kunz, Thomas H.; Naugle, Dave; Nibbelink, Nathan P.; Niemuth, Neal D.

    2011-01-01

    Wind energy offers the potential to reduce carbon emissions while increasing energy independence and bolstering economic development. However, wind energy has a larger land footprint per Gigawatt (GW) than most other forms of energy production, making appropriate siting and mitigation particularly important. Species that require large unfragmented habitats and those known to avoid vertical structures are particularly at risk from wind development. Developing energy on disturbed lands rather than placing new developments within large and intact habitats would reduce cumulative impacts to wildlife. The U.S. Department of Energy estimates that it will take 241 GW of terrestrial based wind development on approximately 5 million hectares to reach 20% electricity production for the U.S. by 2030. We estimate there are ∼7,700 GW of potential wind energy available across the U.S., with ∼3,500 GW on disturbed lands. In addition, a disturbance-focused development strategy would avert the development of ∼2.3 million hectares of undisturbed lands while generating the same amount of energy as development based solely on maximizing wind potential. Wind subsidies targeted at favoring low-impact developments and creating avoidance and mitigation requirements that raise the costs for projects impacting sensitive lands could improve public value for both wind energy and biodiversity conservation. PMID:21533285

  1. Challenging the win-win discourse on conservation and development: analyzing support for marine protected areas

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    Tomas Chaigneau

    2016-03-01

    Full Text Available Conservation designations such as protected areas are increasing in numbers around the world, yet it is widely reported that many are failing to reach their objectives. They are frequently promoted as opportunities for win-win outcomes that can both protect biodiversity and lead to economic benefits for affected communities. This win-win view characterizes the dominant discourse surrounding many protected areas. Although this discourse and the arguments derived from it may lead to initial acceptance of conservation interventions, this study shows how it does not necessarily result in compliance and positive attitudes toward specific protected areas. Consequently, the discourse has important implications not just for making the case for protected area implementation, but also for the likelihood of protected areas reaching their objectives. We explain how the win-win discourse influences support for marine protected areas (MPAs and, ultimately, their success. Using data from focus groups, questionnaires, and in-depth interviews at three MPA sites in the Philippines, we identified three reasons why the win-win discourse can negatively influence prolonged support for MPAs: dashed expectations, inequity, and temptation. Through an understanding of these issues, it becomes possible to suggest improvements that can be made pre-MPA implementation that can lead to prolonged support of MPAs. A focus on less tangible and economic MPA benefits, aligning MPA goals with cultural and social values, and higher levels of transparency when describing MPA outcomes are all ways in which prolonged support of MPAs can be bolstered.

  2. Urbanization, housing and environment: Megacities of Africa

    Directory of Open Access Journals (Sweden)

    Olusola Oladapo Makinde

    2012-12-01

    Full Text Available This paper takes a look at urbanization, housing and environment in Africa megacities; it enumerates the problems caused by the continued influx of migrant into cities, and state the government, private and public organization effort in solving these challenges. It found out that with proper management, the chilling prospect of a serious deterioration in quality of life could be averted. The report noted that continuing migration from rural to urban areas will expand the number of megacities, and it concedes that megacities are often plagued by environmental deterioration, inadequate housing, traffic congestion, social alienation slums, crime and homelessness. Etc. The paper, observed that megacities are important to a country's economic development, and also provide residents with a satisfying quality of life, if properly managed. The report looked for ways of solving the problems to a significant degree and observed that nearly in all cases, the gaps between demand and supply are management related, and recommends ways of improving the quality of citizen life by provision of adequate and quality housing, reduction in land costs, healthy environment, clean water and sanitation services, security within the city, employment opportunity, bolstering urban farming, and improving public transportation and make sure that the megacities are beneficial to the environment as well as to the national economy. The paper admits that the solutions are far from easy. It is difficult to predict what will happen if there are shortfalls in the financing of megacity growth and management.

  3. Segmentation of Textures Defined on Flat vs. Layered Surfaces using Neural Networks: Comparison of 2D vs. 3D Representations.

    Science.gov (United States)

    Oh, Sejong; Choe, Yoonsuck

    2007-08-01

    Texture boundary detection (or segmentation) is an important capability in human vision. Usually, texture segmentation is viewed as a 2D problem, as the definition of the problem itself assumes a 2D substrate. However, an interesting hypothesis emerges when we ask a question regarding the nature of textures: What are textures, and why did the ability to discriminate texture evolve or develop? A possible answer to this question is that textures naturally define physically distinct (i.e., occluded) surfaces. Hence, we can hypothesize that 2D texture segmentation may be an outgrowth of the ability to discriminate surfaces in 3D. In this paper, we conducted computational experiments with artificial neural networks to investigate the relative difficulty of learning to segment textures defined on flat 2D surfaces vs. those in 3D configurations where the boundaries are defined by occluding surfaces and their change over time due to the observer's motion. It turns out that learning is faster and more accurate in 3D, very much in line with our expectation. Furthermore, our results showed that the neural network's learned ability to segment texture in 3D transfers well into 2D texture segmentation, bolstering our initial hypothesis, and providing insights on the possible developmental origin of 2D texture segmentation function in human vision.

  4. Cognitive empathy contributes to poor social functioning in schizophrenia: Evidence from a new self-report measure of cognitive and affective empathy.

    Science.gov (United States)

    Michaels, Tania M; Horan, William P; Ginger, Emily J; Martinovich, Zoran; Pinkham, Amy E; Smith, Matthew J

    2014-12-30

    Cognitive empathy impairments have been linked to poor social functioning in schizophrenia. However, prior studies primarily used self-reported empathy measures developed decades ago that are not well-aligned with contemporary models of empathy. We evaluated empathy and its relationship to social functioning in schizophrenia using the recently developed Questionnaire of Cognitive and Affective Empathy (QCAE). Schizophrenia (n=52) and healthy comparison (n=37) subjects completed the QCAE, Interpersonal Reactivity Index (IRI), and measures of neurocognition, symptoms, and social functioning. Between-group differences on the QCAE, and relationships between QCAE and IRI subscales, neurocognition, symptoms, and social functioning were examined. The schizophrenia group reported significantly lower cognitive empathy than comparison subjects, which was driven by low online simulation scores. Cognitive empathy explained significant variance in social functioning after accounting for neurocognition and symptoms. Group differences for affective empathy were variable; the schizophrenia group reported similar proximal responsivity, but elevated emotion contagion relative to comparison subjects. These findings bolster support for the presence and functional significance of impaired cognitive empathy in schizophrenia using a contemporary measure of empathy. Emerging evidence that some aspects of affective empathy may be unimpaired or hyper-responsive in schizophrenia and implications for the assessment and treatment of empathy in schizophrenia are discussed.

  5. A Review of the Water and Energy Sectors and the Use of a Nexus Approach in Abu Dhabi

    Science.gov (United States)

    Paul, Parneet; Al Tenaiji, Ameena Kulaib; Braimah, Nuhu

    2016-01-01

    Rapid population increase coupled with urbanization and industrialization has resulted in shortages of water in the Middle East. This situation is further exacerbated by global climate change due to greenhouse gas emissions. Recent research advocates that solutions to the global water security and scarcity crisis must involve water–energy nexus approaches. This means adopting policies and strategies that harmonize these inter-related sectors to minimize environmental impact while maximizing human benefit. In the case of Abu Dhabi, when designing and locating oil/gas refineries and associated power generation facilities, previous relevant decisions were based on simple economic and geographical grounds, such as nearness to oil rigs, pipelines, existing industries and port facilities, etc. The subsequent design and location of water abstraction and treatment works operated by the waste heat from these refining and/or power generation processes was catered for as an afterthought, meaning that there is now a mismatch between the water and energy supplies and demands. This review study was carried out to show how Abu Dhabi is trying now to integrate its water–energy sectors using a nexus approach so that future water/power infrastructure is designed optimally and operated in harmony, especially in regard to future demand. Based upon this review work, some recommendations are made for designers and policy makers alike to bolster the nexus approach that Abu Dhabi is pursuing. PMID:27023583

  6. Post-Conflict History Education in Finland, South Africa and Bosnia-Herzegovina

    Directory of Open Access Journals (Sweden)

    Sirkka Ahonen

    2013-08-01

    Full Text Available A post-conflict society tends to get locked in a history war. As the practice of history in its broad sense is a moral craft, representations of guilt and victimhood prevail in social memory. The representations are often bolstered by mythical references, wherefore deconstruction of myths is expected from history education for the purposes of post-conflict reconciliation. This article deals with the post-conflict uses of history in Finland, South Africa and Bosnia-Herzegovina. The three cases constitute examples of a class war, a race conflict and an ethno-religious armed clash. The memory politics and history curricula differ between the cases. Their comparison indicates, how far an imposition of one ´truth´, a dialogue of two ´truths´ and segregation of different memory communities are feasible strategies of post-conflict history education. The article suggests that history lessons can be an asset instead of a liability in the pursuit of reconciliation.

  7. The Technological Expansion of Sociability: Virtual Communities as Imagined Communities

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    Camelia Grădinaru

    2016-07-01

    Full Text Available The reception of Benedict Anderson’s ideas was very fruitful in many disciplines, and his work provided key concepts that can now throw a clarifying light in some blurry matters. The expression “imagined community” has known a remarkable proliferation, a situation that led to both the formation of a research direction and to the perpetuation of a cliché. In this respect, my article pointed out some suggestive characteristics of virtual communities, explaining why the imagined community is a valuable subject for the theorists of new media. The impossibility to know in person all the members of a big community is just one factor that determines its imagined face. Moreover, the set of values and inner presuppositions that guide the members are important bricks in the construction of community. In my opinion, the virtual community is imagined as a multi-layered experience (technological, conversational, relational etc.. The dynamic of a virtual community contains the tension amongst these layers and the degree of its imagined side depends on multiple factors. In order to illustrate these aspects, I gave a brief example by analysing a Romanian virtual community, using the triad common language – temporality – high centers. In spite of its limitations, the perspectives offered by this concept are still useful for understanding the nature of online communities. Thus, the imagined community is a valuable set of beliefs and practices that underlie and bolster the effective meaning and functioning of the virtual communities.

  8. Private Equity Capital in a Less Developed Economy: Evidence, Issues and Perspectives

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    Melusi Mpofu

    2015-10-01

    Full Text Available This study investigates the structure of the private equity industry and issues that impact on its development and growth in Zimbabwe. Studies conducted internationally have unequivocally demonstrated the importance of private equity investments in assisting firms at start/growth phase and decline phase. However there is a dearth of literature on how these financial intermediaries assist in unlocking firm value from an emerging markets perspective. The study uses the document analysis and an exploratory research paradigms to achieve the stated objectives. The study finds that the venture capital industry in Zimbabwe mimics similar industries in other countries except that it is constrained by market liquidity. Lack of regulation and viable business sectors coupled with excessive risks in the political economy narrows the scope of private equity operations. Several issues impacting on the development of the private equity industry are identified and evaluated. The study has policy implications for the development of regulatory framework to bolster the growth of the private equity industry in emerging market economies. This study provides new evidence and policy suggestions on the operations of the private equity industry in a liquidity constrained and less developed economy.

  9. A Review of Technology-Based Youth and Family-Focused Interventions.

    Science.gov (United States)

    MacDonell, Kathleen Watson; Prinz, Ronald J

    2016-10-27

    In the past 10 years, mental and behavioral health has seen a proliferation of technology-based interventions in the form of online and other computer-delivered programs. This paper focuses on technology-based treatment and preventive interventions aimed at benefitting children and adolescents via either involving the parents and families, or only the youth. The review considered only technology-based interventions that had at least one published study with a randomized controlled trial design. Questions being addressed included: (1) What are the technology-based interventions in the mental/behavioral health area that have been systematically evaluated in published studies? (2) What are the common and unique characteristics of these interventions and their application with respect to sample characteristics, target problems, and technology characteristics (platforms, structures, elements, and communication formats)? and (3) Which intervention approaches and strategies have accrued the greatest evidence? The review identified 30 technology-based psychosocial interventions for children and families, 19 of which were parent or family-focused (32 studies) and 11 of which were youth-focused (in 13 studies). For the parent/family-focused interventions, greatest promise was found in those that addressed either youth behavioral problems or depressive/anxious symptoms, as well as more general bolstering of parenting efficacy. The youth-focused interventions showed some promise in reducing depressive/anxious symptoms. Advantages and disadvantages of the technology-based approaches were considered, and areas for future research and development were discussed.

  10. Worldwide Engagement for Sustainable Energy Strategies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-01

    Almost 40 years after the Agency’s founding, the IEA responsibility for ensuring access to global oil supplies is still a core mandate. Yet over the course of its history, the IEA’s responsibilities have expanded along with both the international energy economy and conceptions of energy security itself. Our mission to promote secure and sustainable energy provision spans the energy mix. At the same time, a changing global energy map means that the industrialised nations of the world no longer dominate energy consumption. The IEA must work in close co-operation with partner countries and organisations worldwide to achieve its three core objectives: energy security, economic prosperity, and environmental sustainability. Working toward international commitments to reduce greenhouse gas emissions that cause global climate change; facilitating energy technology exchange, innovation and deployment; improving modern energy access to the billions of people who are without it; bolstering both cleanliness and security through energy efficiency; and promoting flexible and functioning energy markets – these efforts complement our traditional core responsibilities of mitigating the effects of supply disruptions and improving statistical transparency.

  11. Explaining participation of private forest owners in economic incentives. Case studies in Europe

    DEFF Research Database (Denmark)

    Górriz, E.; Mäntymaa, E.; Petucco, C.;

    2014-01-01

    Taking part in the implementation of a voluntary policy instrument for land use management implies motivational requirements of the targeted landowner. Increasing knowledge on the potential economic, managerial and attitudinal factors helps design incentives in accordance and facilitates an effec......Taking part in the implementation of a voluntary policy instrument for land use management implies motivational requirements of the targeted landowner. Increasing knowledge on the potential economic, managerial and attitudinal factors helps design incentives in accordance and facilitates...... an effective performance. We analyzed surveys and interviews addressed to private forest owners, at country or regional level in five European countries. Participation rates for different schemes aimed at enhancing the provision of ecosystem services were contrasted with a range of landowners’ socio-economic...... objectives or the land management measures they promote. It demonstrates that the design of mechanisms bolstering synergies between current landowners’ practices and expectations to those demanded by externals have more likelihood of success than those implying drastic management changes. On the other hand...

  12. Improved prediction of antibody VL-VH orientation.

    Science.gov (United States)

    Marze, Nicholas A; Lyskov, Sergey; Gray, Jeffrey J

    2016-10-01

    Antibodies are important immune molecules with high commercial value and therapeutic interest because of their ability to bind diverse antigens. Computational prediction of antibody structure can quickly reveal valuable information about the nature of these antigen-binding interactions, but only if the models are of sufficient quality. To achieve high model quality during complementarity-determining region (CDR) structural prediction, one must account for the VL-VH orientation. We developed a novel four-metric VL-VH orientation coordinate frame. Additionally, we extended the CDR grafting protocol in RosettaAntibody with a new method that diversifies VL-VH orientation by using 10 VL-VH orientation templates rather than a single one. We tested the multiple-template grafting protocol on two datasets of known antibody crystal structures. During the template-grafting phase, the new protocol improved the fraction of accurate VL-VH orientation predictions from only 26% (12/46) to 72% (33/46) of targets. After the full RosettaAntibody protocol, including CDR H3 remodeling and VL-VH re-orientation, the new protocol produced more candidate structures with accurate VL-VH orientation than the standard protocol in 43/46 targets (93%). The improved ability to predict VL-VH orientation will bolster predictions of other parts of the paratope, including the conformation of CDR H3, a grand challenge of antibody homology modeling.

  13. The study of perceived stress, coping strategy and self-efficacy of Chinese undergraduate nursing students in clinical practice.

    Science.gov (United States)

    Zhao, Fang-Fang; Lei, Xiao-Ling; He, Wei; Gu, Yan-Hong; Li, Dong-Wen

    2015-08-01

    The aim of the study was to explore the coping strategy and the effects of self-efficacy of Chinese undergraduate nursing students when they face the stress in clinical practice. Convenience sampling was used to recruit undergraduate nursing students in Mainland China who have practiced 3 months in hospitals in their final college year. Self-report questionnaires including demographics, Perceived Stress Scale, coping behaviour inventory and Generalized Self-Efficacy Scale were collected. The results showed that during clinical practice, assignments and workload were the most common stress to students; transference was the most frequently used coping strategy by students. Self-efficacy not only had a positive main effect in predicting the frequency of use of staying optimistic and problem solving strategies but also moderated the effects of stress from taking care of patients on transference strategy, as well as stress from assignments and workload on problem solving strategy. It is essential to bolster the students' self-efficacy to reduce stress and adopt positively the coping strategies during clinical practice.

  14. A Bridge to the Stars: A Model High School-to-College Pipeline to Improve Diversity in STEM

    Science.gov (United States)

    McIntosh, Daniel H.; Jennings, Derrick H.

    2017-01-01

    Increasing participation by historically underrepresented Americans in the STEM workforce remains a national priority. Existing strategies have failed to increase diversity especially in the physical sciences despite federal mandates. To meet this urgent challenge, it is imperative to immediately identify and support the expansion of effective high school-to-college STEM pipelines. A Bridge to the Stars (ABttS) is a creative and tested pipeline designed to steadily increase the numbers of disadvantaged 15-21 year-olds pursuing and completing 4-year STEM degrees. This unique program offers extended engagement in astronomy, arguably the most accessible window to science, through a 3-tier STEM immersion program of innovative learning (in a freshman science course), authentic research training (in a freshman science lab), and supportive near-peer mentoring at U.Missouri-Kansas City, an urban research university. Each tier of the ABttS pipeline by itself has the potential to broaden student aspirations for careers as technological innovators or STEM educators. Students who elect to transition through multiple tiers will substantially reinforce their successes with STEM activities, and significantly bolster their self-esteem necessary to personally manifest STEM aspirations. We will summarize the impact of this program after 5 years, and share our latest improvements. The long-term mission of ABttS is to see urban educational institutions across the U.S. adopt similar pipelines in all STEM disciplines built on the ABttS model.

  15. Evaluation of Urban Spaces from the Perspective of Universal Design Principles: The Case of Konya/Turkey

    Directory of Open Access Journals (Sweden)

    H. Filiz Alkan Meshur

    2016-08-01

    Full Text Available During the process of accessing services provided within urban interior and outer spaces the elderly and disabled individuals encounter with a myriad of problems due to the limitations posed by structured environments. This limitation hinders elderly and disabled individuals from mobility without assistance, which in turn negatively affects their full participation to urban and social life. Rearrangement of urban spaces to meet the needs of elderly and disabled individuals would correspondingly bolster life quality of the entire range of users. Within the scope of present research, as mandated by universal design principles to stick to plans and designs approaches inclusive for all users, it is aimed to conduct evaluations on the use of urban outer spaces situated within Konya city center. In the hypothetical and theoretical part of this paper, the perception of disability throughout historical process has been examined from a sociological perspective. In addition, concept of universal design, its principles and gravity have also been elaborated. In the part dealing with the case study, outer spaces within Konya city center have been analyzed with respect to universal design principles and a range of suggestions have been developed.

  16. A dual-systems perspective on addiction: contributions from neuroimaging and cognitive training.

    Science.gov (United States)

    McClure, Samuel M; Bickel, Warren K

    2014-10-01

    Dual-systems theories explain lapses in self-control in terms of a conflict between automatic and deliberative modes of behavioral control. Numerous studies have now tested whether the brain areas that control behavior are organized in a manner consistent with dual-systems models. Brain regions directly associated with the mesolimbic dopamine system, the nucleus accumbens and ventromedial prefrontal cortex in particular, capture some of the features assumed by automatic processing. Regions in the lateral prefrontal cortex are more closely linked to deliberative processing and the exertion of self-control in the suppression of impulses. While identifying these regions crudely supports dual-systems theories, important modifications to what constitutes automatic and deliberative behavioral control are also suggested. Experiments have identified various means by which automatic processes may be sculpted. Additional work decomposes deliberative processes into component functions such as generalized working memory, reappraisal of emotional stimuli, and prospection. The importance of deconstructing dual-systems models into specific cognitive processes is clear for understanding and treating addiction. We discuss intervention possibilities suggested by recent research, and focus in particular on cognitive training approaches to bolster deliberative control processes that may aid quit attempts.

  17. Toward ubiquitous environmental gas sensors-capitalizing on the promise of graphene.

    Science.gov (United States)

    Ratinac, Kyle R; Yang, Wenrong; Ringer, Simon P; Braet, Filip

    2010-02-15

    Atomically thin sheets of carbon known as "graphene" have captured the imagination of much of the scientific world during the past few years. Although these single sheets of graphite were under our noses for years-within technologies ranging from the humble pencil, which has been around since at least 1565 (Petroski, H. The Pencil: A History of Design and Circumstance; Alfred A. Knopf: New York, 1993), to modern nuclear reactors-graphene was merely considered as part of graphite's crystal structure until 2004, when Novoselov, Geim, and colleagues (Science 2004, 306, 666-669) first presented some of the surprising electrical properties of graphene layers they had isolated by mechanically peeling sheets off graphite crystals. Today, graphene's unique electronic structures and properties, bolstered by other intriguing properties discovered in the intervening years, threaten the dominance of carbon nanotubes, a more mature allotrope of carbon, in potential applications from electronics to sensors. In this review, we will consider the promise of graphene for producing small-scale gas sensors for environmental monitoring.

  18. A Very Large Array Search for Intermediate-Mass Black Holes in Globular Clusters in M81

    CERN Document Server

    Wrobel, J M; Middleton, M J

    2016-01-01

    Nantais et al. used the Hubble Space Telescope to localize probable globular clusters (GCs) in M81, a spiral galaxy at a distance of 3.63 Mpc. Theory predicts that GCs can host intermediate-mass black holes (IMBHs) with masses M_BH \\sim 100 - 100,000 M_sun. Finding IMBHs in GCs could validate a formation channel for seed BHs in the early universe, bolster gravitational-wave predictions for space missions, and test scaling relations between stellar systems and the central BHs they host. We used the NRAO Karl G. Jansky Very Large Array (VLA) to search for the radiative signatures of IMBH accretion from 206 probable GCs in a mosaic of M81. The observing wavelength was 5.5 cm and the spatial resolution was 1.5 arcsec (26.4 pc). None of the individual GCs are detected, nor are weighted-mean image stacks of the 206 GCs and the 49 massive GCs with stellar masses M_star \\gtrsim 200,000 M_sun. We apply a semi-empirical model to predict the mass of an IMBH that, if undergoing accretion in the long-lived hard X-ray stat...

  19. How do medical device manufacturers' websites frame the value of health innovation? An empirical ethics analysis of five Canadian innovations.

    Science.gov (United States)

    Lehoux, P; Hivon, M; Williams-Jones, B; Miller, F A; Urbach, D R

    2012-02-01

    While every health care system stakeholder would seem to be concerned with obtaining the greatest value from a given technology, there is often a disconnect in the perception of value between a technology's promoters and those responsible for the ultimate decision as to whether or not to pay for it. Adopting an empirical ethics approach, this paper examines how five Canadian medical device manufacturers, via their websites, frame the corporate "value proposition" of their innovation and seek to respond to what they consider the key expectations of their customers. Our analysis shows that the manufacturers' framing strategies combine claims that relate to valuable socio-technical goals and features such as prevention, efficiency, sense of security, real-time feedback, ease of use and flexibility, all elements that likely resonate with a large spectrum of health care system stakeholders. The websites do not describe, however, how the innovations may impact health care delivery and tend to obfuscate the decisional trade-offs these innovations represent from a health care system perspective. Such framing strategies, we argue, tend to bolster physicians' and patients' expectations and provide a large set of stakeholders with powerful rhetorical tools that may influence the health policy arena. Because these strategies are difficult to counter given the paucity of evidence and its limited use in policymaking, establishing sound collective health care priorities will require solid critiques of how certain kinds of medical devices may provide a better (i.e., more valuable) response to health care needs when compared to others.

  20. Origins of food crops connect countries worldwide

    Science.gov (United States)

    Achicanoy, Harold A.; Bjorkman, Anne D.; Navarro-Racines, Carlos; Guarino, Luigi; Flores-Palacios, Ximena; Engels, Johannes M. M.; Wiersema, John H.; Dempewolf, Hannes; Sotelo, Steven; Ramírez-Villegas, Julian; Castañeda-Álvarez, Nora P.; Fowler, Cary; Jarvis, Andy; Rieseberg, Loren H.; Struik, Paul C.

    2016-01-01

    Research into the origins of food plants has led to the recognition that specific geographical regions around the world have been of particular importance to the development of agricultural crops. Yet the relative contributions of these different regions in the context of current food systems have not been quantified. Here we determine the origins (‘primary regions of diversity’) of the crops comprising the food supplies and agricultural production of countries worldwide. We estimate the degree to which countries use crops from regions of diversity other than their own (‘foreign crops’), and quantify changes in this usage over the past 50 years. Countries are highly interconnected with regard to primary regions of diversity of the crops they cultivate and/or consume. Foreign crops are extensively used in food supplies (68.7% of national food supplies as a global mean are derived from foreign crops) and production systems (69.3% of crops grown are foreign). Foreign crop usage has increased significantly over the past 50 years, including in countries with high indigenous crop diversity. The results provide a novel perspective on the ongoing globalization of food systems worldwide, and bolster evidence for the importance of international collaboration on genetic resource conservation and exchange.

  1. The Struggle of the Russian Intelligentsia for the Spiritual Development of Caucasus Krai (the 19th Century

    Directory of Open Access Journals (Sweden)

    Hope O. Blejh

    2015-03-01

    Full Text Available This article features new little-known materials. Through the example of some of the more prominent representatives of the Russian scientific and creative intelligentsia, the author analyzes certain awareness-raising views on cultural building in the region. The author reveals in a survey/abstract form that interest in the Caucasus had been exhibited by the entire frontline Russian intelligentsia in the persons of its best representatives: A.S. Pushkin, M.Yu. Lermontov, A.S. Griboyedov, L.N. Tolstoy, A.P. Belyayev, A.A. Bestuzhev-Marlinsky, I.G. Burtsov, N.N. Muraviev, P.A. Mukhanov, V.D. Sukhorukov, V.S. Tolstoy, and many others. It has been proven that the ideas of compassion for common people were the basis for the creative work of the Russian general public and were shared by Caucasian thinkers (Adil-Girey, G. Dzasokhov, Kazen-Bek, Khan-Girey, and many others as well, whose works were published in Russian and Caucasian periodicals. This facilitated the boosting of the national self-consciousness of the mountaineer ethnoses and bolstering mutual friendship between them and great Russian people.

  2. The Energy Box

    Energy Technology Data Exchange (ETDEWEB)

    Friedmann, S J; Homer-Dixon, T

    2004-07-12

    Only Nixon could go to China. And maybe only petroleum industry CEOs can spur action on global climate change. Here's Lord Browne, head of BP, in a recent issue of Foreign Affairs magazine: 'Global temperatures have risen by about 0.6 degrees Celsius since the nineteenth century. Other measures of climate bolster the theory that the world is getting warmer. . . . [The] trend is undoubtedly due in large part to substantial increases in carbon dioxide (CO2) emissions from human activity.' But should we do something about this trend? Browne is unequivocal. In a speech to the Council on Foreign Relations at about the same time his article appeared, he declared: 'It would be too great a risk to stand by, do nothing, and to wait so long that when the impact on the climate really does begin to be felt, you have to take action which is so disruptive as to cause serious damage to the world's economy. There is a very strong case for precautionary action.'

  3. Response of female beetles to LIDAR derived topographic variables in Eastern boreal mixedwood forests (Coleoptera, Carabidae).

    Science.gov (United States)

    Work, Timothy T; Onge, Benoit St; Jacobs, J M

    2011-01-01

    Biodiversity monitoring is increasingly being bolstered with high resolution data derived from remote sensing such as LIDAR (Light Detection and Ranging). We derived a series of topographical variables, including slope, azimuth, ground curvature and flow accumulation from LIDAR images and compared these to captures of female carabids in pitfall traps in Eastern boreal mixedwood forests. We developed a series of species-specific logistic models predicting the proportion of females for eight dominant species, including Agonum retractum, Calathus ingratus, Platynus decentis, Pterostichus adstrictus, Pterostichus coracinus, Pterostichus pensylvanicus, Sphaeroderus nitidicollis and Synuchus impunctatus. We used these models to test three hypotheses related to how the modest topography in boreal forests could influence the availability of microhabitats and possibly potential sites for oviposition and larval development. In general, topographic features such as north facing slopes and high flow accumulation were important predictors of the proportion of females. Models derived from larger scale topography, such as hillsides or small watersheds on the order of ¼-1 ha were better predictors of the proportion of females than were models derived from finer scale topography such as hummocks and small depressions. We conclude that topography likely influences the distribution of carabids based on hydrological mechanisms rather than factors related to temperature. We further suggest based on the scale of responses that these hydrological mechanisms may be linked to the attenuation of past disturbances by wildfire and the propensity of unburned forest patches and fire skips.

  4. Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines

    Energy Technology Data Exchange (ETDEWEB)

    Weir, Genevieve M. [Suite 411, 1344 Summer St., Immunovaccine Inc., Halifax, NS, B3H 0A8 (Canada); Room 11-L1, Sir Charles Tupper Building, Department of Microbiology & Immunology, Dalhousie University, 5850 College St, Halifax, NS, B3H 1X5 (Canada); Liwski, Robert S. [Room 11-L1, Sir Charles Tupper Building, Department of Microbiology & Immunology, Dalhousie University, 5850 College St, Halifax, NS, B3H 1X5 (Canada); Room 206E, Dr. D. J. Mackenzie Building, Department of Pathology, Dalhousie University, 5788 University Avenue, Halifax, NS, B3H 2Y9 (Canada); Mansour, Marc [Suite 411, 1344 Summer St., Immunovaccine Inc., Halifax, NS, B3H 0A8 (Canada)

    2011-08-05

    Chemotherapy has been a mainstay in cancer treatment for many years. Despite some success, the cure rate with chemotherapy remains unsatisfactory in some types of cancers, and severe side effects from these treatments are a concern. Recently, understanding of the dynamic interplay between the tumor and immune system has led to the development of novel immunotherapies, including cancer vaccines. Cancer vaccines have many advantageous features, but their use has been hampered by poor immunogenicity. Many developments have increased their potency in pre-clinical models, but cancer vaccines continue to have a poor clinical track record. In part, this could be due to an inability to effectively overcome tumor-induced immune suppression. It had been generally assumed that immune-stimulatory cancer vaccines could not be used in combination with immunosuppressive chemotherapies, but recent evidence has challenged this dogma. Chemotherapies could be used to condition the immune system and tumor to create an environment where cancer vaccines have a better chance of success. Other types of immunotherapies could also be used to modulate the immune system. This review will discuss how immune modulation by chemotherapy or immunotherapy could be used to bolster the effects of cancer vaccines and discuss the advantages and disadvantages of these treatments.

  5. Towards new business models for R&D for novel antibiotics.

    Science.gov (United States)

    So, A D; Gupta, N; Brahmachari, S K; Chopra, I; Munos, B; Nathan, C; Outterson, K; Paccaud, J P; Payne, D J; Peeling, R W; Spigelman, M; Weigelt, J

    2011-04-01

    In the face of a growing global burden of resistance to existing antibiotics, a combination of scientific and economic challenges has posed significant barriers to the development of novel antibacterials over the past few decades. Yet the bottlenecks at each stage of the pharmaceutical value chain-from discovery to post-marketing-present opportunities to reengineer an innovation pipeline that has fallen short. The upstream hurdles to lead identification and optimization may be eased with greater multi-sectoral collaboration, a growing array of alternatives to high-throughput screening, and the application of open source approaches. Product development partnerships and South-South innovation platforms have shown promise in bolstering the R&D efforts to tackle neglected diseases. Strategies that delink product sales from the firms' return on investment can help ensure that the twin goals of innovation and access are met. To effect these changes, both public and private sector stakeholders must show greater commitment to an R&D agenda that will address this problem, not only for industrialized countries but also globally.

  6. Transmission and epidemiology of zoonotic protozoal diseases of companion animals.

    Science.gov (United States)

    Esch, Kevin J; Petersen, Christine A

    2013-01-01

    Over 77 million dogs and 93 million cats share our households in the United States. Multiple studies have demonstrated the importance of pets in their owners' physical and mental health. Given the large number of companion animals in the United States and the proximity and bond of these animals with their owners, understanding and preventing the diseases that these companions bring with them are of paramount importance. Zoonotic protozoal parasites, including toxoplasmosis, Chagas' disease, babesiosis, giardiasis, and leishmaniasis, can cause insidious infections, with asymptomatic animals being capable of transmitting disease. Giardia and Toxoplasma gondii, endemic to the United States, have high prevalences in companion animals. Leishmania and Trypanosoma cruzi are found regionally within the United States. These diseases have lower prevalences but are significant sources of human disease globally and are expanding their companion animal distribution. Thankfully, healthy individuals in the United States are protected by intact immune systems and bolstered by good nutrition, sanitation, and hygiene. Immunocompromised individuals, including the growing number of obese and/or diabetic people, are at a much higher risk of developing zoonoses. Awareness of these often neglected diseases in all health communities is important for protecting pets and owners. To provide this awareness, this review is focused on zoonotic protozoal mechanisms of virulence, epidemiology, and the transmission of pathogens of consequence to pet owners in the United States.

  7. Computational biology and bioinformatics in Nigeria.

    Science.gov (United States)

    Fatumo, Segun A; Adoga, Moses P; Ojo, Opeolu O; Oluwagbemi, Olugbenga; Adeoye, Tolulope; Ewejobi, Itunuoluwa; Adebiyi, Marion; Adebiyi, Ezekiel; Bewaji, Clement; Nashiru, Oyekanmi

    2014-04-01

    Over the past few decades, major advances in the field of molecular biology, coupled with advances in genomic technologies, have led to an explosive growth in the biological data generated by the scientific community. The critical need to process and analyze such a deluge of data and turn it into useful knowledge has caused bioinformatics to gain prominence and importance. Bioinformatics is an interdisciplinary research area that applies techniques, methodologies, and tools in computer and information science to solve biological problems. In Nigeria, bioinformatics has recently played a vital role in the advancement of biological sciences. As a developing country, the importance of bioinformatics is rapidly gaining acceptance, and bioinformatics groups comprised of biologists, computer scientists, and computer engineers are being constituted at Nigerian universities and research institutes. In this article, we present an overview of bioinformatics education and research in Nigeria. We also discuss professional societies and academic and research institutions that play central roles in advancing the discipline in Nigeria. Finally, we propose strategies that can bolster bioinformatics education and support from policy makers in Nigeria, with potential positive implications for other developing countries.

  8. Gender dichotomization at the level of ingroup identity: what it is, and why men use it more than women.

    Science.gov (United States)

    Bosson, Jennifer K; Michniewicz, Kenneth S

    2013-09-01

    In 5 studies (N = 756), we show that men's relative to women's gender ingroup identities are characterized by greater levels of gender dichotomization, a tendency to distance masculine from feminine traits. We demonstrate further that men's gender dichotomization is motivated, in part, by a need to eschew femininity from their ingroup identity to bolster a precarious gender status. Studies 1-3 establish and replicate the basic effect, and rule out alternative explanations (positivity, projection, status striving) for men's tendency to dichotomize more than women. Studies 4 and 5 demonstrate the motivated nature of gender dichotomization by establishing that men, but not women, dichotomize more strenuously when reminded of the precariousness of their gender status, and report stronger motivation to restore their gender status upon learning that their ingroup is becoming less dichotomized. Across 3 studies, strength of identification with their gender group moderates men's dichotomization tendencies. Discussion considers the implications of these findings for understanding the precarious nature of manhood and identifies practical applications of gender dichotomization in the interpersonal realm.

  9. Structural community factors and sub-optimal engagement in HIV care among low-income women in the Deep South of the USA.

    Science.gov (United States)

    Walcott, Melonie; Kempf, Mirjam-Colette; Merlin, Jessica S; Turan, Janet M

    2016-01-01

    This study describes the ways in which poverty and other structural factors create a risk environment for sub-optimal engagement in HIV care among low-income women living with HIV in the Southern USA, contributing to existing health disparities. We conducted a qualitative study in 2012, involving in-depth interviews with 14 stakeholders (service providers and representatives of community-based organisations) and 7 focus-group discussions with 46 women living with HIV (89% African American). A thematic approach in the context of the social ecological model guided data analysis. Data were coded and analysed using NVivo qualitative software. The findings suggested that structural community factors, such as poverty, poor employment opportunities, limited access to healthcare resources, stigma, transportation challenges and access to illicit substances, may work independently and in synergy to impact women's health seeking behaviour and decision-making, thereby influencing their ability to engage in HIV care. Interventions designed to improve engagement in HIV care should address structural factors to bolster low-income women's ability to engage in care.

  10. ASTEROSEISMOLOGY OF THE SOLAR ANALOGS 16 Cyg A AND B FROM KEPLER OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Metcalfe, T. S.; Dogan, G. [High Altitude Observatory, NCAR, P.O. Box 3000, Boulder, CO 80307 (United States); Chaplin, W. J.; Garcia, R. A.; Basu, S.; Deheuvels, S.; Miglio, A. [Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106 (United States); Appourchaux, T. [Institut d' Astrophysique Spatiale, Univ Paris-Sud, UMR8617, CNRS, Batiment 121, 91405 Orsay Cedex (France); Brandao, I. [Centro de Astrofisica and Faculdade de Ciencias, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Creevey, O. L.; Salabert, D. [Laboratoire Lagrange, UMR7293, Observatoire de la Cote d' Azur, Universite de Nice Sophia-Antipolis, CNRS, BP 4229, 06304 Nice Cedex 4 (France); Eggenberger, P. [Observatoire de Geneve, Universite de Geneve, 51 Ch. des Maillettes, CH-1290 Sauverny (Switzerland); Karoff, C. [Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C (Denmark); Stello, D.; Benomar, O. [Sydney Institute for Astronomy (SIfA), School of Physics, University of Sydney, NSW 2006 (Australia); Y Latin-Small-Letter-Dotless-I ld Latin-Small-Letter-Dotless-I z, M.; Celik, Z. [Department of Astronomy and Space Sciences, Ege University, Bornova, 35100 Izmir (Turkey); Antia, H. M. [Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005 (India); Howe, R. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Regulo, C. [Instituto de Astrofisica de Canarias, 38205 La Laguna, Tenerife (Spain); and others

    2012-03-20

    The evolved solar-type stars 16 Cyg A and B have long been studied as solar analogs, yielding a glimpse into the future of our own Sun. The orbital period of the binary system is too long to provide meaningful dynamical constraints on the stellar properties, but asteroseismology can help because the stars are among the brightest in the Kepler field. We present an analysis of three months of nearly uninterrupted photometry of 16 Cyg A and B from the Kepler space telescope. We extract a total of 46 and 41 oscillation frequencies for the two components, respectively, including a clear detection of octupole (l = 3) modes in both stars. We derive the properties of each star independently using the Asteroseismic Modeling Portal, fitting the individual oscillation frequencies and other observational constraints simultaneously. We evaluate the systematic uncertainties from an ensemble of results generated by a variety of stellar evolution codes and fitting methods. The optimal models derived by fitting each component individually yield a common age (t = 6.8 {+-} 0.4 Gyr) and initial composition (Z{sub i} = 0.024 {+-} 0.002, Y{sub i} = 0.25 {+-} 0.01) within the uncertainties, as expected for the components of a binary system, bolstering our confidence in the reliability of asteroseismic techniques. The longer data sets that will ultimately become available will allow future studies of differential rotation, convection zone depths, and long-term changes due to stellar activity cycles.

  11. Adding to the HIV Prevention Portfolio – the Achievement of Structural Changes by 13 Connect to Protect® Coalitions

    Science.gov (United States)

    Chutuape, Kate S.; Muyeed, Adaline Z.; Willard, Nancy; Greenberg, Lauren; Ellen, Jonathan M.

    2015-01-01

    Opportunities to control risk factors that contribute to HIV transmission and acquisition extend far beyond individuals and include addressing social and structural determinants of HIV risk, such as inadequate housing, poor access to healthcare and economic insecurity. The infrastructure within communities, including the policies and practices that guide institutions and organizations, should be considered crucial targets for change. This paper examines the extent to which 13 community coalitions across the U.S. and Puerto Rico were able to achieve “structural change” objectives (i.e., new or modified practices or policies) as an intermediate step toward the long-term goal of reducing HIV risk among adolescents and young adults (12-24 years old). The study resulted in the completion of 245 objectives with 70% categorized as structural in nature. Coalitions targeted social services, education and government as primary community sectors to adopt structural changes. A median of 12 key actors and six new key actors contributed to accomplishing structural changes. Structural change objectives required a median of seven months to complete. The structural changes achieved offer new ideas for community health educators and practitioners seeking to bolster their HIV prevention agenda. PMID:25632407

  12. Patterns and biases in climate change research on amphibians and reptiles: a systematic review.

    Science.gov (United States)

    Winter, Maiken; Fiedler, Wolfgang; Hochachka, Wesley M; Koehncke, Arnulf; Meiri, Shai; De la Riva, Ignacio

    2016-09-01

    Climate change probably has severe impacts on animal populations, but demonstrating a causal link can be difficult because of potential influences by additional factors. Assessing global impacts of climate change effects may also be hampered by narrow taxonomic and geographical research foci. We review studies on the effects of climate change on populations of amphibians and reptiles to assess climate change effects and potential biases associated with the body of work that has been conducted within the last decade. We use data from 104 studies regarding the effect of climate on 313 species, from 464 species-study combinations. Climate change effects were reported in 65% of studies. Climate change was identified as causing population declines or range restrictions in half of the cases. The probability of identifying an effect of climate change varied among regions, taxa and research methods. Climatic effects were equally prevalent in studies exclusively investigating climate factors (more than 50% of studies) and in studies including additional factors, thus bolstering confidence in the results of studies exclusively examining effects of climate change. Our analyses reveal biases with respect to geography, taxonomy and research question, making global conclusions impossible. Additional research should focus on under-represented regions, taxa and questions. Conservation and climate policy should consider the documented harm climate change causes reptiles and amphibians.

  13. The Sensitization of French Observatory Directors to Astronomical Heritage

    Science.gov (United States)

    Le Guet Tully, Françoise; Davoigneau, Jean

    2012-09-01

    An inventory of the heritage of historical astronomical observatories was launched in the mid 1990s as part of a collaboration between the Ministry of Research and the Ministry of Culture. This has produced a significant body of knowledge not only on astronomical instruments, but also on the specificities of astronomical sites and on the architecture of observatories. Other major results of this operation are (i) the development of numerous works on the institutional history of observatories and (ii), at the request of a few directors, the protection as "historical monuments" of some buildings and of collections of instruments. Given that knowledge about astronomical heritage is a prerequisite for proper conservation and intelligent outreach, and given also that the protection of such heritage (as historical monuments) is a major asset that bolsters its cultural value, the long term sustainability of such heritage depends on political decisions and the search for financial support. We shall describe the complex administrative situation of French observatories and outline the various actions undertaken recently to sensitize their directors to astronomical heritage issues.

  14. [Reform in mental health services--from whence and to where].

    Science.gov (United States)

    Haver, Eitan; Shani, Mordechai; Kotler, Moshe; Fast, Dov; Elizur, Avner; Baruch, Yehuda

    2005-05-01

    For years the subject of mental health has been neglected in Israel, and reform of mental health services is now of paramount importance. Psychiatric medicine has altered considerably over the years, and emphasis is shifting from treatment in mental health institutions to treatment at the community level. This transition is the result of the awakening of groups in our society advocating civil rights for the mentally ill and their integration into the community. This process is also bolstered by the advent of new anti-psychotic drugs. However, the social and medical infrastructure set up to deal with these issues has been found lacking. Over the past few years the Minister of Health has appointed a number of committees to address this issue, and they have all recommended extensive reform of mental health services in Israel. The recommendations handed down by the committees are for: (1) Restructure of mental health services, with emphasis on community services and gradual reduction of psychiatric beds; (2) Allocation of additional funding specifically ear-marked for the mentally challenged, enabling transfer of stabilized patients out of the hospital setting and often lengthy and unnecessary hospitalization, into community rehabilitation centers; (3) Transfer of responsibility for health insurance for mentally ill people from the State to the Health Funds, enabling integration of psychiatric treatment into the general treatment framework. The reform has already been initiated. This body of work will review the stages, processes and the difficulties that preceded the reform.

  15. Transfer from research/academia to clinical/regulated.

    Science.gov (United States)

    Chowdhury, Ferdousi; Williams, Anthony

    2016-10-01

    We focus here on how the interface in academia has adapted in their approach to assessing the PDs of biological agents to better understand mechanisms at an early stage. This understanding enables drugs to be modified early and to be reassessed before progressing to late stage trials. We discuss how these efforts are now being bolstered by a network of consortia involving industry, academia and regulatory bodies, to bring together resources, knowledge and a harmonization in bioanalytical techniques. We highlight how the regulatory guidance still lags behind the rapid advancement in biologicals and associated analytical techniques, especially in immunotherapies and immunological bioassays. Despite this, new collaborative groups are working together to deliver robust and accurate results essential for identifying the most promising drugs to progress from early phase academic research to late phase industry based trials. We show how the relationship between academia and not-for-profit organizations with large pharma and emerging biotech companies has shifted toward a more collaborative effort in bringing new therapies to the forefront.

  16. Identification and Characterisation CRN Effectors in Phytophthora capsici Shows Modularity and Functional Diversity.

    Directory of Open Access Journals (Sweden)

    Remco Stam

    Full Text Available Phytophthora species secrete a large array of effectors during infection of their host plants. The Crinkler (CRN gene family encodes a ubiquitous but understudied class of effectors with possible but as of yet unknown roles in infection. To appreciate CRN effector function in Phytophthora, we devised a simple Crn gene identification and annotation pipeline to improve effector prediction rates. We predicted 84 full-length CRN coding genes and assessed CRN effector domain diversity in sequenced Oomycete genomes. These analyses revealed evidence of CRN domain innovation in Phytophthora and expansion in the Peronosporales. We performed gene expression analyses to validate and define two classes of CRN effectors, each possibly contributing to infection at different stages. CRN localisation studies revealed that P. capsici CRN effector domains target the nucleus and accumulate in specific sub-nuclear compartments. Phenotypic analyses showed that few CRN domains induce necrosis when expressed in planta and that one cell death inducing effector, enhances P. capsici virulence on Nicotiana benthamiana. These results suggest that the CRN protein family form an important class of intracellular effectors that target the host nucleus during infection. These results combined with domain expansion in hemi-biotrophic and necrotrophic pathogens, suggests specific contributions to pathogen lifestyles. This work will bolster CRN identification efforts in other sequenced oomycete species and set the stage for future functional studies towards understanding CRN effector functions.

  17. Conservative treatment of neuromuscular scoliosis in adult tetraplegia: a case report.

    Science.gov (United States)

    Hastings, Jennifer D; Dickson, Julie; Tracy, Linsey; Baniewich, Christine; Levine, Cedar

    2014-12-01

    We report successful correction of new onset neuromuscular scoliosis without spinal surgery in a man who is 30-years post-American Spinal Injury Association Impairment Scale grade A C6 injury with new onset of left neuromuscular scoliosis (Cobb angle 45°) after a motor vehicle collision. Interventions included nightly low-load prolonged stretching (LLPS) (4h left side lying over bolster), a series of 6 botulinum toxin injections (BTIs) at 3-month intervals, and progressive seating adjustments to counteract the spinal curvature. Monthly seating adjustments included rear quadrant wedging, lateral supports, and hip blocking to promote erect and symmetrical posture. A normative Cobb angle (5°) was achieved after 8 months of treatment. Improvements in alignment were demonstrated in physical examination outcome measures at the final session and follow-up. LLPS, seating adjustments, and paraspinal BTI are nonsurgical options for treating neuromuscular scoliosis in adults with tetraplegia. Further studies are necessary to determine optimum protocols and examine generalizability of these treatment methods.

  18. Making the innovation case in Open Access scholary communication

    CERN Document Server

    CERN. Geneva

    2005-01-01

    It seems almost unnecessary to have to elaborate additional reasons for the adoption of Open Access scholarly communication (OA sc) as manifested through Open Access journals and self-archiving practices. To those active within the OA arena, the case has been convincingly made, and current arguments merely need to be disseminated beyond the Library and Information Science (LIS) sphere. However, it is my contention that a convincing argument for OA sc needs to be launched from the Science Policy perspective if any government mandated pro-OA policy changes are to be effected. This paper, then, is an attempt at taking the OA discussion beyond the LIS arena and into the realm of Science and Innovation Policy. Using Innovation Theory as its theoretical framework, it is argued that Open Access scholarly communication can only serve to bolster Innovation Systems, be they national, regional, or sectoral. The case of South Africa is taken as an illustrative example, though the case can and will be generalised to beyon...

  19. Testing Capital Asset Pricing Model: Empirical Evidences from Indian Equity Market

    Directory of Open Access Journals (Sweden)

    Kapil CHOUDHARY

    2010-11-01

    Full Text Available The present study examines the Capital Asset Pricing Model (CAPM for the Indian stock market using monthly stock returns from 278 companies of BSE 500 Index listed on the Bombay stock exchange for the period of January 1996 to December 2009. The findings of this study are not substantiating the theory’s basic result that higher risk (beta is associated with higher levels of return. The model does explain, however, excess returns and thus lends support to the linear structure of the CAPM equation. The theory’s prediction for the intercept is that it should equal zero and the slope should equal the excess returns on the market portfolio. The results of the study lead to negate the above hypotheses and offer evidence against the CAPM. The tests conducted to examine the nonlinearity of the relationship between return and betas bolster the hypothesis that the expected return-beta relationship is linear. Additionally, this study investigates whether the CAPM adequately captures all-important determinants of returns including the residual variance of stocks. The results exhibit that residual risk has no effect on the expected returns of portfolios.

  20. Harnessing heterologous and endogenous CRISPR-Cas machineries for efficient markerless genome editing in Clostridium.

    Science.gov (United States)

    Pyne, Michael E; Bruder, Mark R; Moo-Young, Murray; Chung, Duane A; Chou, C Perry

    2016-05-09

    Application of CRISPR-Cas9 systems has revolutionized genome editing across all domains of life. Here we report implementation of the heterologous Type II CRISPR-Cas9 system in Clostridium pasteurianum for markerless genome editing. Since 74% of species harbor CRISPR-Cas loci in Clostridium, we also explored the prospect of co-opting host-encoded CRISPR-Cas machinery for genome editing. Motivation for this work was bolstered from the observation that plasmids expressing heterologous cas9 result in poor transformation of Clostridium. To address this barrier and establish proof-of-concept, we focus on characterization and exploitation of the C. pasteurianum Type I-B CRISPR-Cas system. In silico spacer analysis and in vivo interference assays revealed three protospacer adjacent motif (PAM) sequences required for site-specific nucleolytic attack. Introduction of a synthetic CRISPR array and cpaAIR gene deletion template yielded an editing efficiency of 100%. In contrast, the heterologous Type II CRISPR-Cas9 system generated only 25% of the total yield of edited cells, suggesting that native machinery provides a superior foundation for genome editing by precluding expression of cas9 in trans. To broaden our approach, we also identified putative PAM sequences in three key species of Clostridium. This is the first report of genome editing through harnessing native CRISPR-Cas machinery in Clostridium.

  1. Regulatory T Cells in Colorectal Cancer: From Biology to Prognostic Relevance

    Energy Technology Data Exchange (ETDEWEB)

    Mougiakakos, Dimitrios [Department of Oncology and Pathology, Immune and Gene Therapy Unit, Cancer Centre Karolinska, CCK R8:01, 17176 Stockholm (Sweden)

    2011-03-29

    Regulatory T cells (Tregs) were initially described as “suppressive” lymphocytes in the 1980s. However, it took almost 20 years until the concept of Treg-mediated immune control in its present form was finally established. Tregs are obligatory for self-tolerance and defects within their population lead to severe autoimmune disorders. On the other hand Tregs may promote tolerance for tumor antigens and even hamper efforts to overcome it. Intratumoral and systemic accumulation of Tregs has been observed in various types of cancer and is often linked to worse disease course and outcome. Increase of circulating Tregs, as well as their presence in mesenteric lymph nodes and tumor tissue of patients with colorectal cancer de facto suggests a strong involvement of Tregs in the antitumor control. This review will focus on the Treg biology in view of colorectal cancer, means of Treg accumulation and the controversies regarding their prognostic significance. In addition, a concise overview will be given on how Tregs and their function can be targeted in cancer patients in order to bolster an inherent immune response and/or increase the efficacy of immunotherapeutic approaches.

  2. Incomplete Markets and Imperfect Institutions: Some Challenges Posed by Trust for Contemporary Health Care and Health Policy.

    Science.gov (United States)

    Schlesinger, Mark; Gray, Bradford H

    2016-08-01

    As contemporary health policy promotes evidence-based practices using targeted incentives, policy makers may lose track of vital aspects of care that are difficult to measure. For more than a half century, scholars have recognized that these latter aspects play a crucial role in high-quality care and equitable health system performance but depend on the potentially frail reed of providers' trustworthiness: that is, their commitment to facets and outcomes of care not easily assessed by external parties. More recently, early experience with pay for performance in health settings suggests that enhancing financial rewards for the measurable undermines providers' commitment to the unmeasurable, degrading the trustworthiness of their practices. Reformers have looked to revised professional norms or reorganized practice arrangements to bolster the intrinsic motivations required for trustworthiness. We suggest here that these responses are likely to prove inadequate. We propose that they be complemented by a renewed policy-making commitment to nonprofit ownership among health care providers, insurers, and integrated delivery systems. We identify some of the concerns raised in the past with ownership-based policies and propose a set of responses. If these are pursued in combination, they hold the promise of a sustainable ownership-based policy reform for the United States.

  3. Exploring the Role of Self-Esteem and Parenting Patterns on Alcohol Use and Abuse Among Adolescents

    Science.gov (United States)

    Glozah, Franklin N.

    2014-01-01

    The type of parental child-rearing practices used by parents and guardians substantially influence children’s self-esteem and consequently their decision to engage in alcohol use, its abuse. The aim of this study was to explore the role of self-esteem and parenting patterns on alcohol use and abuse among adolescents. Three hundred and sixteen boys and girls in Senior High Schools completed self-report questionnaires assessing self-esteem, parenting patterns and alcohol use and abuse. The results showed that while girls reported lesser self-esteem than boys, boys reported higher levels of alcohol use and abuse than girls. Also, authoritative parenting pattern had a positive effect on self-esteem and a negative effect on alcohol use. On the other hand, authoritarian and permissive parenting patterns had negative effects on self-esteem and positive effects on alcohol use, with slight variations. These results provide valuable information regarding strategies aimed at fostering parent-child relationship and rapport with the ultimate aim of bolstering the self-esteem of adolescents to subsequently eschew insalubrious behaviour, particularly alcohol use and abuse. PMID:26973951

  4. Peace Journalism through the Lense of Conflict Theory: Analysis and Practice

    Directory of Open Access Journals (Sweden)

    Samuel Peleg

    2006-10-01

    Full Text Available Peace Journalism is a bold attempt to redefine and reconstruct the role of journalists who cover conflicts. As a new arena of knowledge, Peace Journalism draws upon several theories and disciplines to enrich its validity and applicability. A major source which peace journalism can rely on to bolster its analytical as well as its normative rigor is conflict theory. This article demonstrates how several insights from conflict theory can advance the lucidity of peace journalism and render it a powerful tool in the hands of reporters and their readers to realize the futility of conflict and to bring about its resolution. More specifically, the article introduces the notion of the media as a third party to a conflict. The third party is the facilitator of communication, the mediator or the arbitrator between the two rivaling sides. It is our contention that Peace Journalism as a third side can best enhance prospects for resolution and reconciliation by changing the norms and habits of reporting conflicts. This is succinctly illustrated in three case studies of protracted conflicts, which are described through the lenses of conflict theory. By contrasting regular newspaper coverage with peace journalism coverage, the merits of the latter are revealed.

  5. Optimizing Health Care Coalitions: Conceptual Frameworks and a Research Agenda.

    Science.gov (United States)

    Hupert, Nathaniel; Biala, Karen; Holland, Tara; Baehr, Avi; Hasan, Aisha; Harvey, Melissa

    2015-12-01

    The US health care system has maintained an objective of preparedness for natural or manmade catastrophic events as part of its larger charge to deliver health services for the American population. In 2002, support for hospital-based preparedness activities was bolstered by the creation of the National Bioterrorism Hospital Preparedness Program, now called the Hospital Preparedness Program, in the US Department of Health and Human Services. Since 2012, this program has promoted linking health care facilities into health care coalitions that build key preparedness and emergency response capabilities. Recognizing that well-functioning health care coalitions can have a positive impact on the health outcomes of the populations they serve, this article informs efforts to optimize health care coalition activity. We first review the landscape of health care coalitions in the United States. Then, using principles from supply chain management and high-reliability organization theory, we present 2 frameworks extending beyond the Office of the Assistant Secretary for Preparedness and Response's current guidance in a way that may help health care coalition leaders gain conceptual insight into how different enterprises achieve similar ends relevant to emergency response. We conclude with a proposed research agenda to advance understanding of how coalitions can contribute to the day-to-day functioning of health care systems and disaster preparedness.

  6. Financial Bubbles, Real Estate Bubbles, Derivative Bubbles, and the Financial and Economic Crisis

    Science.gov (United States)

    Sornette, Didier; Woodard, Ryan

    The financial crisis of 2008, which started with an initially well-defined epicenter focused on mortgage backed securities (MBS), has been cascading into a global economic recession, whose increasing severity and uncertain duration has led and is continuing to lead to massive losses and damage for billions of people. Heavy central bank interventions and government spending programs have been launched worldwide and especially in the USA and Europe, with the hope to unfreeze credit and bolster consumption. Here, we present evidence and articulate a general framework that allows one to diagnose the fundamental cause of the unfolding financial and economic crisis: the accumulation of several bubbles and their interplay and mutual reinforcement have led to an illusion of a "perpetual money machine" allowing financial institutions to extract wealth from an unsustainable artificial process. Taking stock of this diagnostic, we conclude that many of the interventions to address the so-called liquidity crisis and to encourage more consumption are ill-advised and even dangerous, given that precautionary reserves were not accumulated in the "good times" but that huge liabilities were. The most "interesting" present times constitute unique opportunities but also great challenges, for which we offer a few recommendations.

  7. Optimal Site Selection of Electric Vehicle Charging Stations Based on a Cloud Model and the PROMETHEE Method

    Directory of Open Access Journals (Sweden)

    Yunna Wu

    2016-03-01

    Full Text Available The task of site selection for electric vehicle charging stations (EVCS is hugely important from the perspective of harmonious and sustainable development. However, flaws and inadequacies in the currently used multi-criteria decision making methods could result in inaccurate and irrational decision results. First of all, the uncertainty of the information cannot be described integrally in the evaluation of the EVCS site selection. Secondly, rigorous consideration of the mutual influence between the various criteria is lacking, which is mainly evidenced in two aspects: one is ignoring the correlation, and the other is the unconscionable measurements. Last but not least, the ranking method adopted in previous studies is not very appropriate for evaluating the EVCS site selection problem. As a result of the above analysis, a Preference Ranking Organization Method for Enrichment Evaluations (PROMETHEE method-based decision system combined with the cloud model is proposed in this paper for EVCS site selection. Firstly, the use of the PROMETHEE method can bolster the confidence and visibility for decision makers. Secondly, the cloud model is recommended to describe the fuzziness and randomness of linguistic terms integrally and accurately. Finally, the Analytical Network Process (ANP method is adopted to measure the correlation of the indicators with a greatly simplified calculation of the parameters and the steps required.

  8. Chronic neglect and aggression/delinquency: A longitudinal examination.

    Science.gov (United States)

    Logan-Greene, Patricia; Semanchin Jones, Annette

    2015-07-01

    Neglect is the most common form of maltreatment in the United States, yet its impact on development remains understudied, especially for chronic neglect. Chronic neglect is also one of the most costly burdens on child welfare systems. This study examines the effects of chronic neglect, including two subtypes (Failure to Provide and Lack of Supervision) on adolescent aggression and delinquency using a diverse longitudinal sample of youth. Chronic neglect and chronic failure to provide (ages 0-12) predicted aggression/delinquency (age 14) even after controlling for the effects of other maltreatment (ages 0-12). Chronic lack of supervision, however, did not. Gender significantly moderated these effects, suggesting that males are more likely to respond to neglect by becoming aggressive/delinquent. Finally, social problems (age 12) partially mediated for boys, and fully mediated for girls, the connections between chronic neglect and aggression/delinquency, bolstering theorizing that neglect impairs social functioning broadly. Implications include the need for further research on chronic neglect, especially in providing guidance for child welfare systems. Interventions for chronically neglected youth should include social skill development.

  9. Ensuring Resilience of Natural Resources under Exposure to Extreme Climate Events

    Directory of Open Access Journals (Sweden)

    Brent Jacobs

    2016-06-01

    Full Text Available Natural resources directly support rural livelihoods and underpin much of the wealth of rural and regional Australia. Climate change manifesting as increasing frequency and or severity of extreme weather events poses a threat to sustainable management of natural resources because the recurrence of events may exceed the resilience of natural systems or the coping capacity of social systems. We report the findings of a series of participatory workshops with communities in eight discrete landscapes in South East New South Wales, Australia. The workshops focused on how natural resource management (NRM is considered in the Prevent-Prepare-Respond-Recover emergency management cycle. We found that NRM is generally considered only in relation to the protection of life and property and not for the intrinsic value of ecosystem services that support communities. We make three recommendations to improve NRM under extreme climate events. Firstly, the support to communities offered by emergency management agencies could be bolstered by guidance material co-produced with government NR agencies. Secondly, financial assistance from government should specifically target the restoration and maintenance of green infrastructure to avoid loss of social-ecological resilience. Thirdly, action by natural resource dependent communities should be encouraged and supported to better protect ecosystem services in preparation for future extreme events.

  10. THE APPLICATION OF RADAR IN THE UDF DURING WORLD WAR II

    Directory of Open Access Journals (Sweden)

    T.C.B. Vlok

    2012-02-01

    Full Text Available Throughout the history of large decisive campaigns and wars, and more so when opposing forces are clearly defined, appearing on a massive scale, conventional weapons and methods of warfare are produced in enormous quantities, to be used by every able-bodied person available; this because every war holds the threat that a state of attrition will be reached when superiority in numbers will tip the scales. To bolster morale, to minimise what is indeed a fateful attitude, a great deal of effort and energy is devoted to developing the secret weapon, the one that will more than restore the balance. Such were in their time: ballistae, the short sword, bows and arrows, gunpowder, breech loading rifles, machine guns, submarines, aerial bombs, tanks, and poison gas. The World War II crop was roughly: Blitzkrieg, radar, V.-type bombs and the atomic bomb. Great leaps ahead like these, in advance of current practice, were the fruits of labour by devoted and untrammelled "Backroom Boys". They produced the strategic ideas and material which were then handed over to the combat forces to exploit tactically. With a strong element of secrecy and national security ever-present, it was invariably necessary to create new units in the field for such exploitation, rather than to extend the functions of existing organisations. It is against this background that the development of radar in the South African Armed Forces must be seen.

  11. A need analysis of technical writing skill of engineering students in India

    Directory of Open Access Journals (Sweden)

    Evangeline JCK

    2016-01-01

    Full Text Available The development of Science and Technology has bolstered the use of English Language around the world. The purpose of teaching English to non-native speakers of English is to help them in communicating, and more precisely sharing knowledge and information with speakers of other languages. In the field of higher education, the learners need English for Academic purposes (EAP and learn to use it later for occupational purposes (EOP. Students who had their primary education in English, manage to cope up with this way of the world; whereas students from sub-standard schools or vernacular medium of instruction, many times find it very difficult to cope up with the trend. This paper analyses the need to teach technical writing as a course to students of technical education in order to make them competent in academics and later in their work place. A few sample technical writing papers have been assessed and added to substantiate the need for educating students in technical writing skill. A review of literature and available ESP courses have been done to analyse the present strategies in teaching writing. A course was designed and tried to improve technical writing skill of students of higher education.

  12. Influence of ethnocentrism and neo-phobia on ethnic food consumption in Spain.

    Science.gov (United States)

    Camarena, Dena M; Sanjuán, Ana I; Philippidis, George

    2011-08-01

    Over the last decade, a strong upsurge in Spanish immigration has fostered a thriving ethnic food market. To examine indigenous consumer predilections toward ethnic foods, a carefully designed choice experiment is employed, with particular focus on ethnocentricity and food neo-phobia traits on potential purchase decisions. Employing a two level nested logit model, consumers choose to accept/reject ethnic foods, with a positive response met by a further series of different ethnic cuisine and consumption scenario alternatives. Bivariate tests reveal that higher ethnocentric and neo-phobic segments possess common socio-demographic characteristics, whilst neo-phobia plays a significantly stronger role in determining the probability of rejection. Further tests reveal culturally similar Mexican food as the preferred ethnic food across all consumption scenarios. Moreover, the 'restaurant' is the favoured format of consumption, whilst there is evidence of a strong association between specific ethnic food types and consumption formats. The implications of our research suggest that in the short to medium turn, price is a strong strategic variable, whilst marketing strategies must successfully isolate and exploit specific 'ethnic food/consumption scenario' mixes. Finally, stronger messages emphasizing quality and convenience factors are seen as key to bolstering the underrepresented 'home preparation' ethnic food market in Spain.

  13. Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.

    Science.gov (United States)

    Vrablik, Tracy L; Petyuk, Vladislav A; Larson, Emily M; Smith, Richard D; Watts, Jennifer L

    2015-10-01

    Lipid droplets are cytoplasmic organelles that store neutral lipids for membrane synthesis and energy reserves. In this study, we characterized the lipid and protein composition of purified Caenorhabditis elegans lipid droplets. These lipid droplets are composed mainly of triacylglycerols, surrounded by a phospholipid monolayer composed primarily of phosphatidylcholine and phosphatidylethanolamine. The fatty acid composition of the triacylglycerols is rich in fatty acid species obtained from the dietary Escherichia coli, including cyclopropane fatty acids and cis-vaccenic acid. Unlike other organisms, C. elegans lipid droplets contain very little cholesterol or cholesterol esters. Comparison of the lipid droplet proteomes of wild type and high-fat daf-2 mutant strains shows a very similar proteome in both strains, except that the most abundant protein in the C. elegans lipid droplet proteome, MDT-28, is relatively less abundant in lipid droplets isolated from daf-2 mutants. Functional analysis of lipid droplet proteins identified in our proteomic studies indicated an enrichment of proteins required for growth and fat homeostasis in C. elegans. Finally, we confirmed the localization of one of the newly identified lipid droplet proteins, ACS-4. We found that ACS-4 localizes to the surface of lipid droplets in the C. elegans intestine and skin. This study bolsters C. elegans as a model to study the dynamics and functions of lipid droplets in a multicellular organism.

  14. Tumor infiltrating lymphocytes in ovarian cancer.

    Science.gov (United States)

    Santoiemma, Phillip P; Powell, Daniel J

    2015-01-01

    The accumulation of tumor infiltrating lymphocytes (TILs) in ovarian cancer is prognostic for increased survival while increases in immunosuppressive regulatory T-cells (Tregs) are associated with poor outcomes. Approaches that bolster tumor-reactive TILs may limit tumor progression. However, identifying tumor-reactive TILs in ovarian cancer has been challenging, though adoptive TIL therapy in patients has been encouraging. Other forms of TIL immunomodulation remain under investigation including Treg depletion, antibody-based checkpoint modification, activation and amplification using dendritic cells, antigen presenting cells or IL-2 cytokine culture, adjuvant cytokine injections, and gene-engineered T-cells. Many approaches to TIL manipulation inhibit ovarian cancer progression in preclinical or clinical studies as monotherapy. Here, we review the impact of TILs in ovarian cancer and attempts to mobilize TILs to halt tumor progression. We conclude that effective TIL therapy for ovarian cancer is at the brink of translation and optimal TIL activity may require combined methodologies to deliver clinically-relevant treatment.

  15. Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

    Directory of Open Access Journals (Sweden)

    Manish Jaiswal

    2015-07-01

    Full Text Available Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration--defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin trafficking. In an unbiased forward genetic screen designed to isolate mutations that cause photoreceptor degeneration, we identified mutations in a nuclear-encoded mitochondrial gene, ppr, a homolog of human LRPPRC. We found that ppr is required for protection against light-induced degeneration. Its function is essential to maintain membrane depolarization of the photoreceptors upon repetitive light exposure, and an impaired phototransduction cascade in ppr mutants results in excessive Rhodopsin1 endocytosis. Moreover, loss of ppr results in a reduction in mitochondrial RNAs, reduced electron transport chain activity, and reduced ATP levels. Oxidative stress, however, is not induced. We propose that the reduced ATP level in ppr mutants underlies the phototransduction defect, leading to increased Rhodopsin1 endocytosis during light exposure, causing photoreceptor degeneration independent of oxidative stress. This hypothesis is bolstered by characterization of two other genes isolated in the screen, pyruvate dehydrogenase and citrate synthase. Their loss also causes a light-induced degeneration, excessive Rhodopsin1 endocytosis and reduced ATP without concurrent oxidative stress, unlike many other mutations in mitochondrial genes that are associated with elevated oxidative stress and light-independent photoreceptor demise.

  16. The Christian ethics of socio-economic development promoted by the Catholic Social Teaching

    Directory of Open Access Journals (Sweden)

    Tony E. Persico

    2011-11-01

    Full Text Available This paper highlights the relationship between economic scienceand Christian moral in order to analyze the idea of socio-economic development promoted by the Catholic Social Teaching (CST. In the first period leading up to the Second Vatican Council (1891-1962, from Pope Leo XIII to Pope John XXIII, the idea of development was connected both to technical and industrial progress, and to the universal values of justice, charity, and truth,which national communities were asked to follow. During the Conciliar period (1962-1979, the concept of development assumes a social and economic dimension, and so it becomes one of the main pillars of Catholic Social Teaching, which introduces the earliest definition of integral human development. Ultimately, in the post-Conciliar phase (1979-2009 including Benedict XVI’s pontificate, the idea of integral human development reaches its maturity by incorporating the complexity of real-world economic interactions. Finally, this paper shows how the ethics bolstered by the Catholic Social Teaching is characterized by two distinct but complementary lines of thought: moral rules for both political action, and for socio-economic issues.

  17. Early experience shapes amygdala sensitivity to race: an international adoption design.

    Science.gov (United States)

    Telzer, Eva H; Flannery, Jessica; Shapiro, Mor; Humphreys, Kathryn L; Goff, Bonnie; Gabard-Durman, Laurel; Gee, Dylan D; Tottenham, Nim

    2013-08-14

    In the current study, we investigated how complete infant deprivation to out-group race impacts behavioral and neural sensitivity to race. Although monkey models have successfully achieved complete face deprivation in early life, this is typically impossible in human studies. We overcame this barrier by examining youths with exclusively homogenous racial experience in early postnatal development. These were youths raised in orphanage care in either East Asia or Eastern Europe as infants and later adopted by American families. The use of international adoption bolsters confidence of infant exposure to race (e.g., to solely Asian faces or European faces). Participants completed an emotional matching task during functional MRI. Our findings show that deprivation to other-race faces in infancy disrupts recognition of emotion and results in heightened amygdala response to out-group faces. Greater early deprivation (i.e., later age of adoption) is associated with greater biases to race. These data demonstrate how early social deprivation to race shapes amygdala function later in life and provides support that early postnatal development may represent a sensitive period for race perception.

  18. Then I started thinking: A qualitative study of innovative projects by secondary students in STEM disciplines

    Science.gov (United States)

    Haggerty, Rebecca

    This qualitative bounded case study examined the self-described motivations of 14 finalists in an international science fair, eight male and six female, between the ages of 15 and 19, from Spain, Ukraine, India, Singapore, Australia, Canada, and the United States. The study used semi-structured interviews and document review to explore participant motivation for undertaking complex research in math and science. Participants reported being highly motivated to pursue their projects, which they found intrinsically interesting and valuable. They enjoyed the benefits that ensued from their science fair activities, including prizes and acclaim, social camaraderie, a satisfying sense of accomplishment and independence, and access to well-known and established practitioners in the field. Female participants experienced a comfortable gender balance in science fairs. Prosocial motivations, and the opportunity to have a positive impact on the world, emerged from the findings as important factors in stimulating the creativity of many participants as well as in bolstering their persistence. Participants showed adaptive patterns of attributions as well as high self-efficacy. They successfully strategized to overcome setbacks, and drew upon their available resources of family, school, and community support to develop and sustain their interest.

  19. CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting B cells.

    Directory of Open Access Journals (Sweden)

    Shweta Jain

    Full Text Available Conventionally, signaling through BCR initiates sequence of events necessary for activation and differentiation of B cells. We report an alternative approach, independent of BCR, for stimulating resting B (RB cells, by involving TLR-2 and CD40--molecules crucial for innate and adaptive immunity. CD40 triggering of TLR-2 stimulated RB cells significantly augments their activation, proliferation and differentiation. It also substantially ameliorates the calcium flux, antigen uptake capacity and ability of B cells to activate T cells. The survival of RB cells was improved and it increases the number of cells expressing activation induced deaminase (AID, signifying class switch recombination (CSR. Further, we also observed increased activation rate and decreased threshold period required for optimum stimulation of RB cells. These results corroborate well with microarray gene expression data. This study provides novel insights into coordination between the molecules of innate and adaptive immunity in activating B cells, in a BCR independent manner. This strategy can be exploited to design vaccines to bolster B cell activation and antigen presenting efficiency, leading to faster and better immune response.

  20. Does Business Model Affect CSR Involvement? A Survey of Polish Manufacturing and Service Companies

    Directory of Open Access Journals (Sweden)

    Marzanna Katarzyna Witek-Hajduk

    2016-02-01

    Full Text Available The study explores links between types of business models used by companies and their involvement in CSR. As the main part of our conceptual framework we used a business model taxonomy developed by Dudzik and Witek-Hajduk, which identifies five types of models: traditionalists, market players, contractors, distributors, and integrators. From shared characteristics of the business model profiles, we proposed that market players and integrators will show significantly higher levels of involvement in CSR than the three other classes of companies. Among other things, both market players and integrators relied strongly on building own brand value and fostering harmonious supply channel relations, which served as a rationale for our hypothesis. The data for the study were obtained through a combined CATI and CAWI survey on a group of 385 managers of medium and large enterprises. The sample was representative for the three Polish industries of chemical manufacturing, food production, and retailing. Statistical methods included confirmatory factor analysis and one-way ANOVA with contrasts and post hoc tests. The findings supported our hypothesis, showing that market players and integrators were indeed more engaged in CSR than other groups of firms. This may suggest that managers in control of these companies could bolster the integrity of their business models by increasing CSR involvement. Another important contribution of the study was to propose and validate a versatile scale for assessing CSR involvement, which showed measurement invariance for all involved industries.