WorldWideScience

Sample records for bohrium 263

  1. 33 CFR 117.263 - Banana River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Banana River. 117.263 Section 117.263 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.263 Banana River. (a) The draw of the Mathers...

  2. 47 CFR 87.263 - Frequencies.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequencies. 87.263 Section 87.263... Aeronautical Enroute and Aeronautical Fixed Stations Aeronautical Enroute Stations § 87.263 Frequencies. (a) Domestic VHF service. (1) Frequencies in the 128.8125-132.125 MHz and 136.4875-137.00 MHz bands...

  3. 32 CFR 263.7 - Emergency vehicles.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Emergency vehicles. 263.7 Section 263.7 National... TRAFFIC AND VEHICLE CONTROL ON CERTAIN DEFENSE MAPPING AGENCY SITES § 263.7 Emergency vehicles. No person shall fail or refuse to yield the right-of-way to an emergency vehicle when operating with siren...

  4. 33 CFR 263.20 - Program funding.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Program funding. 263.20 Section 263.20 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS General § 263.20 Program funding. (a) Program budget....

  5. Dicty_cDB: VHI263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHI263 (Link to dictyBase) - - - Contig-U16423-1 VHI263P (Link to Original site) VHI...263F 581 VHI263Z 800 VHI263P 1361 - - Show VHI263 Library VH (Link to library) Clone ID VHI...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VH/VHI2-C/VHI263Q.Seq.d/ Representative seq. ID VHI...263P (Link to Original site) Representative DNA sequence >VHI263 (VHI263Q) /CSM/VH/VHI2-C/VHI...ttvmieekinqitqcithtla tmvvhiikhsphvirliknnksixfn Frame B: efsstrinffkelvilcqleitkiamelp*isqg*pslirvrqlhqtttq

  6. Dicty_cDB: SHF263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHF263 (Link to dictyBase) - - - Contig-U16433-1 SHF263P (Link to Original site) SHF...263F 145 SHF263Z 559 SHF263P 684 - - Show SHF263 Library SH (Link to library) Clone ID SHF... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SH/SHF2-C/SHF263Q.Seq.d/ Representative seq. ID SHF...263P (Link to Original site) Representative DNA sequence >SHF263 (SHF263Q) /CSM/SH/SHF2-C/SHF2...CACTGGTCCAGCTG sequence update 2002.10.25 Translated Amino Acid sequence syhfylfiy*IIIYLLNYYLLSCVNYLPINFNILY

  7. 12 CFR 263.400 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Scope. 263.400 Section 263.400 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES OF PRACTICE FOR HEARINGS Removal, Suspension, and Debarment of Accountants From Performing Audit...

  8. 12 CFR 263.401 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Definitions. 263.401 Section 263.401 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES OF PRACTICE FOR HEARINGS Removal, Suspension, and Debarment of Accountants From Performing Audit...

  9. 12 CFR 26.3 - Prohibitions.

    Science.gov (United States)

    2010-01-01

    ... total assets of $50 million or more. (c) Major assets. A management official of a depository... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Prohibitions. 26.3 Section 26.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS §...

  10. 12 CFR 263.109 - Further proceedings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Further proceedings. 263.109 Section 263.109... Further proceedings. (a) General rule. The determination of a recommended award shall be made by the... proceedings to amplify the record such as an informal conference, oral argument, additional...

  11. Dicty_cDB: SLC263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC263 (Link to dictyBase) - G01082 DDB0233929 Contig-U11371-1 SLC...263P (Link to Original site) SLC263F 621 SLC263Z 574 SLC263P 1195 - - Show SLC263 Library SL (Link to library) Clone ID SLC...Contig-U11371-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-C/SLC...263Q.Seq.d/ Representative seq. ID SLC263P (Link to Original site) Representative DNA sequence >SLC263 (SLC263Q) /CSM/SL/SLC...2-C/SLC263Q.Seq.d/ CTAAATCAATAATAAACAATTAATCAAAAATGACAATCTTTGATAGCGACGAAGAAGAGT TAGTTAC

  12. Dicty_cDB: CHF263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHF263 (Link to dictyBase) - - - Contig-U16366-1 | Contig-U16429-1 CHF...263P (Link to Original site) CHF263F 672 CHF263Z 718 CHF263P 1370 - - Show CHF263 Library CH (Link to library) Clone ID CHF...366-1 | Contig-U16429-1 Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHF2-C/CHF...263Q.Seq.d/ Representative seq. ID CHF263P (Link to Original site) Representative DNA sequence >CHF263 (CHF...263Q) /CSM/CH/CHF2-C/CHF263Q.Seq.d/ ATATAAATTACCTTATTACTTAAAGATGACAACAAATAATCCATTTGATAAAGTAAAGGA

  13. Dicty_cDB: SLE263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLE263 (Link to dictyBase) - - - Contig-U16455-1 SLE263Z (Link... to Original site) - - SLE263Z 486 - - - - Show SLE263 Library SL (Link to library) Clone ID SLE263 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLE2-C/SLE263Q.Seq.d/ Representative seq. ID SLE26...3Z (Link to Original site) Representative DNA sequence >SLE263 (SLE263Q) /CSM/SL/SLE2-C/SLE263Q.Seq.d/ XXXXX...936 0.0 SLG782 (SLG782Q) /CSM/SL/SLG7-D/SLG782Q.Seq.d/ 936 0.0 SLE701 (SLE701Q) /CSM/SL/SLE7-A/SLE701Q.Seq.d/ 936 0.0 SLE555 (SLE

  14. Properties of an $\\alpha$ particle in a Bohrium $270$ Nucleus under the Generalized Symmetric Woods-Saxon Potential

    CERN Document Server

    Lütfüoğlu, B C

    2016-01-01

    The energy eigenvalues and the wave functions of an $\\alpha$ particle in a Bohrium $270$ nucleus were calculated by solving Schr\\"odinger equation for Generalized Symmetric Woods-Saxon potential. Using the energy spectrum by excluding and including the quasi-bound eigenvalues, entropy, internal energy, Helmholtz energy, and specific heat, as functions of reduced temperature were calculated. Stability and emission characteristics are interpreted in terms of the wave and thermodynamic functions. The kinetic energy of a decayed $\\alpha$ particle was calculated using the quasi-bound states, which is found close to the experimental value.

  15. 12 CFR 263.81 - Definitions.

    Science.gov (United States)

    2010-01-01

    ..., 12 U.S.C. 1841(c), and in the Board's Regulation Y (12 CFR 225.2(a)). (b) Capital Adequacy Guidelines... Capital Adequacy Guidelines or as otherwise established under procedures described in § 263.85 of this... PRACTICE FOR HEARINGS Procedures for Issuance and Enforcement of Directives To Maintain Adequate...

  16. 21 CFR 26.3 - Scope.

    Science.gov (United States)

    2010-04-01

    ... PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN... Provisions for Pharmaceutical Good Manufacturing Practices § 26.3 Scope. (a) The provisions of this subpart... inspections and the good manufacturing practices (GMP's) requirements. (c) Appendix B of this subpart...

  17. 27 CFR 26.263 - Determination of tax on beer.

    Science.gov (United States)

    2010-04-01

    ... beer. 26.263 Section 26.263 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Procedure at Port of Entry From the Virgin Islands § 26.263 Determination of tax on beer. If the certificate prescribed in § 26.205 covers beer, the beer tax will be collected on the basis of the number of barrels...

  18. 12 CFR 263.405 - Petition for reinstatement.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Petition for reinstatement. 263.405 Section 263.405 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE... Audit Services § 263.405 Petition for reinstatement. (a) Form of petition. Unless otherwise ordered...

  19. 32 CFR 263.4 - Registration of vehicles.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Registration of vehicles. 263.4 Section 263.4...) MISCELLANEOUS TRAFFIC AND VEHICLE CONTROL ON CERTAIN DEFENSE MAPPING AGENCY SITES § 263.4 Registration of vehicles. (a) Newly assigned or employed individuals who intend to operate a privately-owned vehicle at...

  20. 12 CFR 263.11 - Service of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Service of papers. 263.11 Section 263.11 Banks... OF PRACTICE FOR HEARINGS Uniform Rules of Practice and Procedure § 263.11 Service of papers. (a) By the parties. Except as otherwise provided, a party filing papers shall serve a copy upon the...

  1. 12 CFR 263.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Filing of papers. 263.10 Section 263.10 Banks... OF PRACTICE FOR HEARINGS Uniform Rules of Practice and Procedure § 263.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery...

  2. 26 CFR 1.263A-7 - Changing a method of accounting under section 263A.

    Science.gov (United States)

    2010-04-01

    ... 5, 1997, the rules of § 1.263A-7T contained in the 26 CFR part 1 edition revised as of April 1, 1997... factory to X's warehouse and in storing those goods at the warehouse until their sale to customers. X... regulations thereunder. (ii) Deemed avoidance of this section—(A) Scope. For purposes of this paragraph...

  3. 12 CFR 263.83 - Issuance of capital directives.

    Science.gov (United States)

    2010-01-01

    ... established in the Board's Capital Adequacy Guidelines, or as otherwise established under the procedures... Capital Adequacy Guidelines or the procedures in § 263.85 of this subpart by a certain date; (2) Adhere to... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Issuance of capital directives. 263.83...

  4. 12 CFR 263.105 - Statement of net worth.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Statement of net worth. 263.105 Section 263.105... Statement of net worth. (a) General rule. A statement of net worth shall be filed with the application for an award of fees. The statement shall reflect the net worth of the applicant and all affiliates...

  5. 40 CFR 263.31 - Discharge clean up.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Discharge clean up. 263.31 Section 263.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... up. A transporter must clean up any hazardous waste discharge that occurs during transportation...

  6. 29 CFR 1952.263 - Compliance staffing benchmarks.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Compliance staffing benchmarks. 1952.263 Section 1952.263... Compliance staffing benchmarks. Under the terms of the 1978 Court Order in AFL-CIO v. Marshall, compliance staffing levels (“benchmarks”) necessary for a “fully effective” enforcement program were required for...

  7. 37 CFR 263.3 - Royalty rates and terms.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Royalty rates and terms. 263.3 Section 263.3 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES RATES AND TERMS FOR CERTAIN TRANSMISSIONS AND THE MAKING OF EPHEMERAL REPRODUCTIONS BY...

  8. Microstructure stability: Optimisation of 263 Ni-based superalloy

    Directory of Open Access Journals (Sweden)

    Crozet Coraline

    2014-01-01

    Full Text Available To reduce CO2 emissions on coal-fired power plant, A-ultra supercritical (A-USC power plant whose steam conditions exceed 700 °C are being developed. At these elevated temperatures, the use of Ni-base superalloys becomes necessary. In this context and within the European project NextGenPower, focus is made on commercial Nimonic C-263 as a candidate material for turbine rotors. Nimonic C-263 is known to have low sensitivity to segregation, high workability and high weldability which are major properties for the manufacture of large shafts. Long-term creep strength is also required for this application and unfortunately Nimonic C-263 shows η-phase precipitation after long-time exposure between 700 °C–900 °C which is detrimental for long-term creep properties. The composition of Nimonic C-263 was thus optimised to overcome the formation of η-phase. Trial tests were made in order to study the effect of hardening contribution elements on microstructural and mechanical properties. Then, a 500 mm diameter forged rotor was made from optimised 263 alloy and shows promising properties.

  9. Characteristics of 263K scrapie agent in multiple hamster species.

    Science.gov (United States)

    Meade-White, Kimberly D; Barbian, Kent D; Race, Brent; Favara, Cynthia; Gardner, Don; Taubner, Lara; Porcella, Stephen; Race, Richard

    2009-02-01

    Transmissible spongiform encephalopathy (TSE) diseases are known to cross species barriers, but the pathologic and biochemical changes that occur during transmission are not well understood. To better understand these changes, we infected 6 hamster species with 263K hamster scrapie strain and, after each of 3 successive passages in the new species, analyzed abnormal proteinase K (PK)-resistant prion protein (PrPres) glycoform ratios, PrPres PK sensitivity, incubation periods, and lesion profiles. Unique 263K molecular and biochemical profiles evolved in each of the infected hamster species. Characteristics of 263K in the new hamster species seemed to correlate best with host factors rather than agent strain. Furthermore, 2 polymorphic regions of the prion protein amino acid sequence correlated with profile differences in these TSE-infected hamster species.

  10. 38 CFR 3.263 - Corpus of estate; net worth.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Corpus of estate; net....263 Corpus of estate; net worth. (a) General. The following rules are for application in determining the corpus of estate of a parent where dependency is a factor under § 3.250, and the net worth of...

  11. 12 CFR 263.82 - Establishment of minimum capital levels.

    Science.gov (United States)

    2010-01-01

    ... Maintain Adequate Capital § 263.82 Establishment of minimum capital levels. The Board has established minimum capital levels for state member banks and bank holding companies in its Capital Adequacy... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Establishment of minimum capital levels....

  12. 29 CFR 500.263 - Authority of the Secretary.

    Science.gov (United States)

    2010-07-01

    ... Administrative Law Judge § 500.263 Authority of the Secretary. The Secretary may modify or vacate the Decision and Order of the Administrative Law Judge whenever he concludes that the Decision and Order: (a) Is... not within the scope of the authority of the Administrative Law Judge, (c) Awards attorney fees...

  13. 27 CFR 25.263 - Production of concentrate and reconstitution of beer.

    Science.gov (United States)

    2010-04-01

    ... and reconstitution of beer. 25.263 Section 25.263 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Beer Concentrate § 25.263 Production of concentrate and reconstitution of beer. (a) Operations at brewery. A brewer may concentrate...

  14. 7 CFR 2.63 - Deputy Under Secretary for Research, Education, and Economics.

    Science.gov (United States)

    2010-01-01

    ... Economics. 2.63 Section 2.63 Agriculture Office of the Secretary of Agriculture DELEGATIONS OF AUTHORITY BY... Under Secretary for Research, Education, and Economics § 2.63 Deputy Under Secretary for Research, Education, and Economics. Pursuant to § 2.21(a), subject to reservations in § 2.21(b), and subject to...

  15. 33 CFR 263.24 - Authority for snagging and clearing for flood control (Section 208).

    Science.gov (United States)

    2010-07-01

    ... clearing for flood control (Section 208). 263.24 Section 263.24 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.24 Authority for snagging and clearing for flood control (Section 208). (a)...

  16. 14 CFR 135.263 - Flight time limitations and rest requirements: All certificate holders.

    Science.gov (United States)

    2010-01-01

    ... requirements: All certificate holders. 135.263 Section 135.263 Aeronautics and Space FEDERAL AVIATION... § 135.263 Flight time limitations and rest requirements: All certificate holders. (a) A certificate holder may assign a flight crewmember and a flight crewmember may accept an assignment for flight...

  17. 33 CFR 263.26 - Small beach erosion control project authority (Section 103).

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Shore Protection Policy § 263... shore and beach restoration and protection projects not specifically authorized by Congress,...

  18. Amor: Investigating The Triple Asteroid System 2001 SN263

    Science.gov (United States)

    Jones, T.; Bellerose, Julie; Lee, P.; Prettyman, T.; Lawrence, D.; Smith, P.; Gaffey, M.; Nolan, M.; Goldsten, J.; Thomas, P.; Veverka, J.; Farquhar, R.; Heldmann, J.; Reddy, V.; Williams, B.; Chartres, J.; DeRosee, R.; Dunham, D.

    2010-10-01

    The Amor mission will rendezvous and land at the triple Near-Earth Asteroid system (153591) 2001 SN263 and execute detailed, in-situ science investigations. The spacecraft reaches 2001 SN263 by using a two-year ΔVEGA (ΔV-Earth Gravity Assist) trajectory with a relatively low launch C3 of 33.5 km2/s2. Rendezvous will enable reconnaissance activities including global and regional imaging, shape modeling, system dynamics, and compositional mapping. After landing, Amor will conduct in-situ imaging (panoramic to microscopic scale) and compositional measurements to include elemental abundance. The main objectives are to 1) establish in-situ the long-hypothesized link between C-type asteroids and the primitive carbonaceous chondrite (CC) meteorites, 2) investigate the nature, origin and evolution of C-type asteroids, and 3) investigate the origin and evolution of a multiple asteroid system. The mission also addresses the distribution of volatiles and organic materials, impact hazards, and resources for future exploration. Amor is managed by NASA Ames Research Center in partnership with Orbital Sciences, KinetX, MDA, and Draper with heritage instruments provided by Ball Aerospace, JHU/APL, and Firestar Engineering. The science team brings experience from NEAR, Hayabusa, Deep Impact, Dawn, LCROSS, Kepler, and Mars missions. In this paper, we describe the science, mission design, and main operational challenges of performing in-situ science at this triple asteroid system. Challenges include landing on the asteroid components, thermal environment, short day-night cycles, and the operation of deployed instruments in a low gravity (10^-5 g) environment.

  19. 47 CFR 25.263 - Information sharing requirements for SDARS terrestrial repeater operators.

    Science.gov (United States)

    2010-10-01

    ... terrestrial repeater operators. 25.263 Section 25.263 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... requirements for SDARS terrestrial repeater operators. This section requires SDARS licensees in the 2320-2345 MHz band to share information regarding the location and operation of terrestrial repeaters with...

  20. 12 CFR 263.404 - Notice of removal, suspension, or debarment.

    Science.gov (United States)

    2010-01-01

    ... accountants and firms. An accountant or accounting firm that provides audit services to a banking organization... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Notice of removal, suspension, or debarment. 263.404 Section 263.404 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF...

  1. 27 CFR 44.263 - To commercial vessels and aircraft for consumption as supplies.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To commercial vessels and aircraft for consumption as supplies. 44.263 Section 44.263 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO EXPORTATION...

  2. 29 CFR 779.263 - Excise taxes not at the retail level.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Excise taxes not at the retail level. 779.263 Section 779... Coverage Excise Taxes § 779.263 Excise taxes not at the retail level. There are also a wide variety of taxes levied at the manufacturer's or distributor's level and not at the retail level. It should...

  3. Indirect slumping of D263 glass on Fused Silica mould

    Science.gov (United States)

    Proserpio, Laura; Wen, Mingwu; Breunig, Elias; Burwitz, Vadim; Friedrich, Peter; Madarasz, Emanuel

    2016-07-01

    The Slumped Glass Optic (SGO) group of the Max Planck Institute for Extraterrestrial physics (MPE) is studying the indirect slumping technology for its application to X-ray telescope manufacturing. Several aspects of the technology have been analyzed in the past. During the last months, we concentrated our activities on the slumping of Schott D263 glass on a precise machined Fused Silica mould: The concave mould was produced by the Italian company Media Lario Technologies with the parabola and hyperbola side of the typical Wolter I design in one single piece. Its shape quality was estimated by optical metrology to be around 6 arcsec Half Energy Width (HEW) in double reflection. The application of an anti-sticking Boron Nitride layer was necessary to avoid the adhesion of the glass on the mould during the forming process at high temperatures. The mould has been used for the slumping of seven mirror segments 200 mm long, 100 mm wide, and with thickness of 200 μm or 400 μm. The influence of the holding time at maximum temperature was explored in this first run of tests. The current results of the activities are described in the paper and plans for further investigations are outlined.

  4. 77 FR 42003 - TA-W-81,263, Chartis Global Services, Inc., a Subsidiary of Chartis, Inc., Regional Processing...

    Science.gov (United States)

    2012-07-17

    ... Employment and Training Administration TA-W-81,263, Chartis Global Services, Inc., a Subsidiary of Chartis, Inc., Regional Processing Organization, Regional Service Center, Houston, TX; TA-W-81,263A, Chartis... certification (TA-W-81,263) to add ``Regional Processing Organization'' and to add workers at an...

  5. Hypolipidemic Effects and Safety of Lactobacillus Reuteri 263 in a Hamster Model of Hyperlipidemia

    Directory of Open Access Journals (Sweden)

    Wen-Ching Huang

    2015-05-01

    Full Text Available We aimed to verify the beneficial effects of probiotic strain Lactobacillus reuteri 263 (Lr263 on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD. Male Golden Syrian hamsters were randomly divided into two groups: normal (n = 8, standard diet (control, and experimental (n = 32, a HCD. After a two-week induction followed by a six-week supplementation with Lr263, the 32 hyperlipidemic hamsters were divided into four groups (n = 8 per group to receive vehicle or Lr263 by oral gavage at 2.1, 4.2, or 10.5 × 109 cells/kg/day for 6 weeks, designated the HCD, 1X, 2X and 5X groups, respectively. The efficacy and safety of Lr263 supplementation were evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC, triacylglycerol (TG cholesterol, high-density lipoprotein cholesterol (HDL-C, and low-density lipoprotein cholesterol (LDL-C, LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. Lr263 supplementation dose dependently increased serum HDL-C level and decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. In addition, Lr263 supplementation had few subchronic toxic effects. Lr263 could be a potential agent with a hypolipidemic pharmacological effect.

  6. Moving object detection method using H.263 video coded data for remote surveillance systems

    Science.gov (United States)

    Kohno, Atsushi; Hata, Toshihiko; Ozaki, Minoru

    1998-12-01

    This paper describes a moving object detection method using H.263 coded data. For video surveillance systems, it is necessary to detect unusual states because there are a lot of cameras in the system and video surveillance is tedious in normal states. We examine the information extracted from H.263 coded data and propose a method of detecting alarm events from that information. Our method consists of two steps. In the first step, using motion vector information, a moving object can be detected based on the vector's size and the similarities between the vectors in one frame and the two adjoining frames. In the second step, using DCT coefficients, the detection errors caused by the change of the luminous intensity can be eliminated based on the characteristics of the H.263's DCT coefficients. Thus moving objects are detected by analyzing the motion vectors and DCT coefficients, and we present some experimental results that show the effectiveness of our method.

  7. 40 CFR 52.263 - Priority treatment for buses and carpools-Los Angeles Region.

    Science.gov (United States)

    2010-07-01

    ... § 52.263 Priority treatment for buses and carpools—Los Angeles Region. (a) Definitions: (1) “Carpool” means a vehicle containing three or more persons. (2) “Bus/carpool lane” means a lane on a street or... agencies to which legal authority has been delegated, shall establish the following system of...

  8. A case of de novo duplication of 15q24-q26.3

    Directory of Open Access Journals (Sweden)

    Hye Ran Kim

    2011-06-01

    Full Text Available Distal duplication, or trisomy 15q, is an extremely rare chromosomal disorder characterized by prenatal and postnatal overgrowth, mental retardation, and craniofacial malformations. Additional abnormalities typically include an unusually short neck, malformations of the fingers and toes, scoliosis and skeletal malformations, genital abnormalities, particularly in affected males, and, in some cases, cardiac defects. The range and severity of symptoms and physical findings may vary from case to case, depending upon the length and location of the duplicated portion of chromosome 15q. Most reported cases of duplication of the long arm of chromosome 15 frequently have more than one segmental imbalance resulting from unbalanced translocations involving chromosome 15 and deletions in another chromosome, as well as other structural chromosomal abnormalities. We report a female newborn with a de novo duplication, 15q24- q26.3, showing intrauterine overgrowth, a narrow asymmetric face with down-slanting palpebral fissures, a large, prominent nose, and micrognathia, arachnodactyly, camptodactyly, congenital heart disease, hydronephrosis, and hydroureter. Chromosomal analysis showed a 46,XX,inv(9(p12q13,dup(15(q24q26.3. Array comparative genomic hybridization analysis revealed a gain of 42 clones on 15q24-q26.3. This case represents the only reported patient with a de novo 15q24-q26.3 duplication that did not result from an unbalanced translocation and did not have a concomitant monosomic component in Korea.

  9. 26 CFR 1.263A-2 - Rules relating to property produced by the taxpayer.

    Science.gov (United States)

    2010-04-01

    ... method to elect a historic absorption ratio in determining additional section 263A costs allocable to... recomputation year. (iii) Method of accounting—(A) Adoption and use. The election to use the historic absorption... ratios, the taxpayer must use the same methods of accounting used in computing its historic...

  10. 33 CFR 263.23 - Small flood control project authority (Section 205).

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Small flood control project..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.23 Small flood control project authority (Section 205). (a) Legislative authority. Section 205 of the...

  11. 45 CFR 263.20 - What definitions apply to Individual Development Accounts (IDAs)?

    Science.gov (United States)

    2010-10-01

    ... nonprofit, tax-exempt organization. Qualified expenditures means expenses entailed in a qualified plan... 45 Public Welfare 2 2010-10-01 2010-10-01 false What definitions apply to Individual Development... Development Accounts? § 263.20 What definitions apply to Individual Development Accounts (IDAs)? The...

  12. 12 CFR 263.5 - Authority of the administrative law judge.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Authority of the administrative law judge. 263... Authority of the administrative law judge. (a) General rule. All proceedings governed by this part shall be... administrative law judge shall have all powers necessary to conduct a proceeding in a fair and impartial...

  13. 26 CFR 1.263(c)-1 - Intangible drilling and development costs in the case of oil and gas wells.

    Science.gov (United States)

    2010-04-01

    ... Intangible drilling and development costs in the case of oil and gas wells. For rules relating to the option to deduct as expenses intangible drilling and development costs in the case of oil and gas wells, see... case of oil and gas wells. 1.263(c)-1 Section 1.263(c)-1 Internal Revenue INTERNAL REVENUE...

  14. 40 CFR 421.263 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Effluent limitations guidelines... economically achievable. 421.263 Section 421.263 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS NONFERROUS METALS MANUFACTURING POINT SOURCE CATEGORY...

  15. Composite Laminate With Coefficient of Thermal Expansion Matching D263 Glass

    Science.gov (United States)

    Robinson, David; Rodini, Benjamin

    2012-01-01

    The International X-ray Observatory project seeks to make an X-ray telescope assembly with 14,000 flexible glass segments. The glass used is commercially available SCHOTT D263 glass. Thermal expansion causes the mirror to distort out of alignment. A housing material is needed that has a matching coefficient of thermal expansion (CTE) so that when temperatures change in the X-ray mirror assembly, the glass and housing pieces expand equally, thus reducing or eliminating distortion. Desirable characteristics of this material include a high stiffness/weight ratio, and low density. Some metal alloys show promise in matching the CTE of D263 glass, but their density is high compared to aluminum, and their stiffness/weight ratio is not favorable. A laminate made from carbon fiber reinforced plastic (CFRP) should provide more favorable characteristics, but there has not been any made with the CTE matching D263 Glass. It is common to create CFRP laminates of various CTEs by stacking layers of prepreg material at various angles. However, the CTE of D263 glass is 6.3 ppm/ C at 20 C, which is quite high, and actually unachievable solely with carbon fiber and resin. A composite laminate has been developed that has a coefficient of thermal expansion identical to that of SCHOTT D263 glass. The laminate is made of a combination of T300 carbon fiber, Eglass, and RS3C resin. The laminate has 50% uni-T300 plies and 50% uni-E-glass plies, with each fiber-layer type laid up in a quasi-isotropic laminate for a total of 16 plies. The fiber volume (percent of fiber compared to the resin) controls the CTE to a great extent. Tests have confirmed that a fiber volume around 48% gives a CTE of 6.3 ppm/ C. This is a fairly simple composite laminate, following well established industry procedures. The unique feature of this laminate is a somewhat unusual combination of carbon fiber with E-glass (fiberglass). The advantage is that the resulting CTE comes out to 6.3 ppm/ C at 20 C, which matches D

  16. The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Vogler, Meike, E-mail: mv62@le.ac.uk [MRC Toxicology Unit, University of Leicester, LE1 9HN Leicester (United Kingdom); Dickens, David, E-mail: David.Dickens@liverpool.ac.uk [Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3GL Liverpool (United Kingdom); Dyer, Martin J.S., E-mail: mjsd1@le.ac.uk [MRC Toxicology Unit, University of Leicester, LE1 9HN Leicester (United Kingdom); Owen, Andrew, E-mail: aowen@liverpool.ac.uk [Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3GL Liverpool (United Kingdom); Pirmohamed, Munir, E-mail: munirp@liv.ac.uk [Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, L69 3GL Liverpool (United Kingdom); Cohen, Gerald M., E-mail: gmc2@le.ac.uk [MRC Toxicology Unit, University of Leicester, LE1 9HN Leicester (United Kingdom)

    2011-05-06

    Highlights: {yields} The BCL2-inhibitor ABT-263 is a substrate for P-glycoprotein. {yields} Apoptosis is inhibited by P-glycoprotein expression. {yields} Overexpression of P-glycoprotein may contribute to resistance to ABT-263 or ABT-737. -- Abstract: Inhibition of BCL2 proteins is one of the most promising new approaches to targeted cancer therapy resulting in the induction of apoptosis. Amongst the most specific BCL2-inhibitors identified are ABT-737 and ABT-263. However, targeted therapy is often only effective for a limited amount of time because of the occurrence of drug resistance. In this study, the interaction of BCL2-inhibitors with the drug efflux transporter P-glycoprotein was investigated. Using {sup 3}H labelled ABT-263, we found that cells with high P-glycoprotein activity accumulated less drug. In addition, cells with increased P-glycoprotein expression were more resistant to apoptosis induced by either ABT-737 or ABT-263. Addition of tariquidar or verapamil sensitized the cells to BCL2-inhibitor treatment, resulting in higher apoptosis. Our data suggest that the BCL2-inhibitors ABT-737 and ABT-263 are substrates for P-glycoprotein. Over-expression of P-glycoprotein may be, at least partly, responsible for resistance to these BCL2-inhibitors.

  17. AN ERROR-RESILIENT H.263+ CODING SCHEME FOR VIDEO TRANSMISSION OVER WIRELESS NETWORKS

    Institute of Scientific and Technical Information of China (English)

    Li Jian; Bie Hongxia

    2006-01-01

    Video transmission over wireless networks has received much attention recently for its restricted bandwidth and high bit-error rate. Based on H.263+, by reversing part stream sequences of each Group Of Block (GOB), an error resilient scheme is presented to improve video robustness without additional bandwidth burden. Error patterns are employed to simulate Wideband Code Division Multiple Access(WCDMA) channels to check out error resilience performances. Simulation results show that both subjective and objective qualities of the reconstructed images are improved remarkably. The mean Peak Signal to Noise Ratio (PSNR)is increased by 0.5dB, and the highest increment is 2dB.

  18. Polarimetry diagnostic on OMEGA EP using a 10-ps, 263-nm probe beam.

    Science.gov (United States)

    Davies, A; Haberberger, D; Boni, R; Ivancic, S; Brown, R; Froula, D H

    2014-11-01

    A polarimetry diagnostic was built and characterized for magnetic-field measurements in laser-plasma experiments on the OMEGA EP laser. This diagnostic was built into the existing 4ω (263-nm) probe system that employs a 10-ps laser pulse collected with an f/4 imaging system. The diagnostic measures the rotation of the probe beam's polarization. The polarimeter uses a Wollaston prism to split the probe beam into orthogonal polarization components. Spatially localized intensity variations between images indicate polarization rotation. Magnetic fields can be calculated by combining the polarimetry data with the measured plasma density profile obtained from angular filter refractometry.

  19. Polarimetry diagnostic on OMEGA EP using a 10-ps, 263-nm probe beam

    Energy Technology Data Exchange (ETDEWEB)

    Davies, A., E-mail: adavies@lle.rochester.edu; Haberberger, D.; Boni, R.; Ivancic, S.; Brown, R.; Froula, D. H. [Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623 (United States)

    2014-11-15

    A polarimetry diagnostic was built and characterized for magnetic-field measurements in laser-plasma experiments on the OMEGA EP laser. This diagnostic was built into the existing 4ω (263-nm) probe system that employs a 10-ps laser pulse collected with an f/4 imaging system. The diagnostic measures the rotation of the probe beam's polarization. The polarimeter uses a Wollaston prism to split the probe beam into orthogonal polarization components. Spatially localized intensity variations between images indicate polarization rotation. Magnetic fields can be calculated by combining the polarimetry data with the measured plasma density profile obtained from angular filter refractometry.

  20. 在无线局域网上实现H.263+视频通信%Realization of the H.263+ Video Commrnication on Wirdlesss LAN

    Institute of Scientific and Technical Information of China (English)

    余智

    2002-01-01

    无线视频业务对包交换环境形成了一个巨大的挑战.由于无线信道呈现出有限的容量、高差错率以及时变和不对称传播的特性,视频应用是非常消耗带宽、差错敏感和不能容许延时的.这种情形就迫使无线视频系统去动态地适应网络资源中的变化.在最近几年中,有一些论文研究了无线网络上的视频传输,在IEEE802.11标准中所提出的传输协议的性能,以及在包交换基础结构网络上的实时视频通信.但是,到目前为止还没有报道支持IP多点广播扩展的用于IEEE802.11,特别是WLAN的视频会议系统上的实验性工作.本文描述了Kinesis,一种用于802.11网络的H.263+视频传输系统.Kinesis支持IP多点广播扩展,以及实现了实时的传输协议用来管理同步和QoS问题.我们把注意力集中在系统结构上,把它作为用于分布式和交互式视听应用的一种普通的通信结构.Kinesis已经在不同的工作条件下得到测试,对于H.263+视频序列具有非常出色的结果.

  1. Efficient Video Transcoding from H.263 to H.264/AVC Standard with Enhanced Rate Control

    Directory of Open Access Journals (Sweden)

    Nguyen Viet-Anh

    2006-01-01

    Full Text Available A new video coding standard H.264/AVC has been recently developed and standardized. The standard represents a number of advances in video coding technology in terms of both coding efficiency and flexibility and is expected to replace the existing standards such as H.263 and MPEG-1/2/4 in many possible applications. In this paper we investigate and present efficient syntax transcoding and downsizing transcoding methods from H.263 to H.264/AVC standard. Specifically, we propose an efficient motion vector reestimation scheme using vector median filtering and a fast intraprediction mode selection scheme based on coarse edge information obtained from integer-transform coefficients. Furthermore, an enhanced rate control method based on a quadratic model is proposed for selecting quantization parameters at the sequence and frame levels together with a new frame-layer bit allocation scheme based on the side information in the precoded video. Extensive experiments have been conducted and the results show the efficiency and effectiveness of the proposed methods.

  2. Deformed Potential Energy of 263Db in a Generalized Liquid Drop Model

    Institute of Scientific and Technical Information of China (English)

    陈宝秋; 马中玉; 赵耀林

    2003-01-01

    The macroscopic deformed potential energy for super-heavy nuclei 263 Db,which governs the entrance and alpha decay channels,is determined within a generalized liquid drop model(GLDM).A quasi-molecular shape is as sumed in the GLDM,which includes volume-,surface-,and Coulomb-energies,proximity effects,mass asymmetry,and an accurate nuclear radius.The microscopic single particle energies are derived from a shell model in an axially deformed Woods-Saxon potential with a quasi-molecular shape.The shell correction is calculated by the Strutinsky method.The total deformed potential energy of a nucleus can be calculated by the macro-microscopic method as the summation of the liquid-drop energy and the Strutinsky shell correction.The theory is applied to predict the deformed potential energy of the experiment 22Ne + 241Am → 263Db* → 259Db + 4n,which was performed on the Heavy Ion Accelerator in Lanzhou.It is found that the neck in the quasi-molecular shape is responsible for the deep valley of the fusion barrier due to the shell corrections.In the cold fusion path,the double-hump fusion barrier is predicted by the shell correction and complete fusion events may occur.

  3. A 780-year record of explosive volcanism from DT263 ice core in east Antarctica

    Institute of Scientific and Technical Information of China (English)

    ZHOU Liya; LI Yuansheng; Jihong Cole-da; TAN Dejun; SUN BO; REN Jiawen; WEI Lijia; WANG Henian

    2006-01-01

    Ice cores recovered from polar ice sheet Received and preserved sulfuric acid fallout from explosive volcanic eruptions. DT263 ice core was retrieved from an east Antarctic location. The ice core is dated using a combination of annual layer counting and volcanic time stratigraphic horizon as 780 years (1215-1996 A.D.). The ice core record demonstrates that during the period of approximately 1460-1800 A.D., the accumulation is sharply lower than the levels prior to and after this period. This period coincides with the most recent neoglacial climatic episode, the "Little Ice Age (LIA)", that has been found in numerous Northern Hemisphere proxy and historic records.The non-sea-salt SO2-4 concentrations indicate seventeen volcanic events in DT263 ice core. Compared with those from previous Antarctic ice cores, significant discrepancies are found between these records in relative volcanic flux of several well-known events. The discrepancies among these records may be explained by the differences in surface topography, accumulation rate, snow drift and distribution which highlight the potential impact of local glaciology on ice core volcanic records, analytical techniques used for sulfate measurement, etc. Volcanic eruptions in middle and high southern latitudes affect volcanic records in Antarctic snow more intensively than those in the Iow latitudes.

  4. Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis.

    Science.gov (United States)

    Hilgers, Valérie; Bushati, Natascha; Cohen, Stephen M

    2010-06-15

    miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. Both microRNAs are expressed in the bristle progenitors, and despite a difference in their seed sequence, they share this key common target. In miR-263a and miR-263b deletion mutants, loss of bristles appears to be sporadic, suggesting that the role of the microRNAs may be to ensure robustness of the patterning process by promoting survival of these functionally specified cells. In the context of the retina, this mechanism ensures that the interommatidial bristles are protected during the developmentally programmed wave of cell death that prunes excess cells in order to refine the pattern of the pupal retina.

  5. Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis.

    Directory of Open Access Journals (Sweden)

    Valérie Hilgers

    Full Text Available miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. Both microRNAs are expressed in the bristle progenitors, and despite a difference in their seed sequence, they share this key common target. In miR-263a and miR-263b deletion mutants, loss of bristles appears to be sporadic, suggesting that the role of the microRNAs may be to ensure robustness of the patterning process by promoting survival of these functionally specified cells. In the context of the retina, this mechanism ensures that the interommatidial bristles are protected during the developmentally programmed wave of cell death that prunes excess cells in order to refine the pattern of the pupal retina.

  6. Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach

    Science.gov (United States)

    Nagasundaram, N.; George Priya Doss, C.; Chakraborty, Chiranjib; Karthick, V.; Thirumal Kumar, D.; Balaji, V.; Siva, R.; Lu, Aiping; Ge, Zhang; Zhu, Hailong

    2016-07-01

    Artemisinin resistance in Plasmodium falciparum threatens global efforts in the elimination or eradication of malaria. Several studies have associated mutations in the PfATP6 gene in conjunction with artemisinin resistance, but the underlying molecular mechanism of the resistance remains unexplored. Associated mutations act as a biomarker to measure the artemisinin efficacy. In the proposed work, we have analyzed the binding affinity and efficacy between PfATP6 and artemisinin in the presence of L263D, L263E and L263K mutations. Furthermore, we performed virtual screening to identify potential compounds to inhibit the PfATP6 mutant proteins. In this study, we observed that artemisinin binding affinity with PfATP6 gets affected by L263D, L263E and L263K mutations. This in silico elucidation of artemisinin resistance enhanced the identification of novel compounds (CID: 10595058 and 10625452) which showed good binding affinity and efficacy with L263D, L263E and L263K mutant proteins in molecular docking and molecular dynamics simulations studies. Owing to the high propensity of the parasite to drug resistance the need for new antimalarial drugs will persist until the malarial parasites are eventually eradicated. The two compounds identified in this study can be tested in in vitro and in vivo experiments as possible candidates for the designing of new potential antimalarial drugs.

  7. MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA.

    Science.gov (United States)

    Wei, Xinghua; Zhou, Ping; Lin, Xuanting; Lin, Yurong; Wu, Sifeng; Diao, Pengfei; Xie, Haiqing; Xie, Keji; Tang, Ping

    2014-10-01

    Patients undergoing androgen blockade therapy develop castration-resistant prostate cancer (CRPC), which is associated with Bcl-2 upregulation and results in disease progression and death. In recent years, promising therapeutic agents, such as the BH3-only mimetic ABT-263 and proteasome inhibitors, have been developed and widely evaluated against a broad spectrum of cancer types, including prostate cancer, alone or in combination with other chemotherapeutic agents. In this study, the antitumor efficacy of ABT-263 and MLN2238 were evaluated as single agents and in combination in four CRPC cell lines: PC3, C4-2B, C4-2, and DU145. The viability of the treated cells and markers of apoptosis were assayed. Protein-protein interactions were analyzed by co-immunoprecipitation in drug-treated cells. Lentivirus-mediated short hairpin RNA was used to knockdown Bax, Mcl-1, and NOXA expressions. We found that ABT-263 and MLN2238 alone exhibited a mild cytotoxicity, and in combination, they elicited a synergistic cytotoxic effect in CRPC cells. The cell apoptosis induced by the combination drug treatment was evidenced by enhanced caspase-3 and Poly (ADP-ribose) polymerase (PARP) cleavage, and annexin-V-positive staining was significantly depleted by Bax knockdown. MLN2238 treatment upregulated NOXA and Mcl-1 expression, leading NOXA/Mcl-1 complexes to disassociate Bak from its complexes with Mcl-1 and enhancing ABT263-triggered Bax activation. NOXA knockdown by short hairpin RNA significantly attenuated the cytotoxicity of ABT-263 and MLN2238 co-administration. In conclusion, MLN2238 and ABT-263 synergistically triggered apoptosis in CRPC cells by upregulating NOXA and activating Bax, indicating a promising therapeutic strategy for the treatment of CRPC.

  8. LkHα 262/263: the paradigm of multiplicity vs disk fraction in low-mass stellar systems.

    Science.gov (United States)

    Velasco, S.; Rebolo, R.; Oscoz, A.; Labadie, L.; Pérez-Garrido, A.

    2017-03-01

    The study of multiple systems and their link with the presence of discs around their components is key to understanding the evolution of low-mass pre-main sequence stars. Although there are indications that high-multiplicity systems are much more frequent among very young stars, until now, only a few of these young low-mass stellar systems have been confirmed. Here, we present high spatial resolution i band imaging of the system formed by LkHα 262 and LkHα 263, in the MBM12 cloud. It was obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. The multiple system LkHα 262/263 is composed of four low-mass very young M-type stars and some discs, including an edge-on disc around LkHα 263C. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkHα 263 are co-moving, that there is orbital motion in the AB pair (0.41arcsec separation), and, remarkably, that LkHα 262-263 is a common proper motion system with a less than 1 mas/yr relative motion. According to BT-settl models the mass of each of the five components is close to 0.4 M and the age is in the range 1-2 Myr. We also give marginal evidence of a cooler companion to LkHα 262, at less than 0.15 arcsec, turning LkHα 262-263 into a five-component likely gravitationally bounded system. The presence of discs in some of the components offers an interesting opportunity to investigate the formation and evolution of discs in the early stages of multiple very low-mass systems.

  9. Clinical analysis of primary diseases in 263 late preterm infants%晚期早产儿263例患病情况临床分析

    Institute of Scientific and Technical Information of China (English)

    翁景文; 刘红; 董世霄; 靳绯; 刘靖媛

    2013-01-01

    目的 分析晚期早产儿(late preterm infant,LPI)生后患病及并发症情况,分析需要呼吸支持治疗的围产期高危因素,为防治提供依据.方法 分析263例晚期早产儿临床资料,用Logistic回归分析的方法 筛选需要呼吸支持的晚期早产儿(LPI)的围产期高危因素,并分析常见临床并发症的发生情况.结果 呼吸困难是LPI生后住院治疗的首要病因,原发病以湿肺(24.33%)和败血症(18.63%)为首,其各系统并发症的发病率均较高,以高胆红素血症(17.87%)、低血糖(13.68%)等为主.logistic回归显示双胎、妊高症、剖宫产及生后窒息是LPI需要呼吸支持的危险因素(均P<0.05).结论 LPI生后易发生多种并发症,应注意观察,及时救治.重视围产期异常分娩因素,是降低LPI生后需要呼吸支持的关键.

  10. Experimental tests of a 263 GHz gyrotron for spectroscopic applications and diagnostics of various media

    Energy Technology Data Exchange (ETDEWEB)

    Glyavin, M. Yu., E-mail: glyavin@appl.sci-nnov.ru; Denisov, G. G.; Zapevalov, V. E. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Gycom Ltd., Nizhny Novgorod (Russian Federation); Chirkov, A. V.; Fokin, A. P.; Kholoptsev, V. V.; Kuftin, A. N.; Luchinin, A. G.; Golubyatnikov, G. Yu.; Malygin, V. I.; Morozkin, M. V.; Manuilov, V. N.; Proyavin, M. D.; Sedov, A. S.; Tsvetkov, A. I. [Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod (Russian Federation); Sokolov, E. V.; Tai, E. M. [Gycom Ltd., Nizhny Novgorod (Russian Federation)

    2015-05-15

    A 263 GHz continuous-wave (CW) gyrotron was developed at the IAP RAS for future applications as a microwave power source in Dynamic Nuclear Polarization / Nuclear magnetic resonance (DNP/NMR) spectrometers. A new experimental facility with a computerized control was built to test this and subsequent gyrotrons. We obtained the maximum CW power up to 1 kW in the 15 kV/0.4 A operation regime. The power about 10 W, which is sufficient for many spectroscopic applications, was realized in the low current 14 kV/0.02 A regime. The possibility of frequency tuning by variation of the coolant temperature about 4 MHz/1 °C was demonstrated. The spectral width of the gyrotron radiation was about 10{sup −6}.

  11. Object-Oriented System-on-Network-on-Chip Template and Implementation: H.263 Case Study

    Institute of Scientific and Technical Information of China (English)

    MA Liwei; SUN Yihe

    2008-01-01

    Network-on-chip (NoC) technology enables a new system-on-chip paradigm, the system-on-network-on-chip (SoNoC) paradigm. One of the challenges in designing application-specific networks is modeling the on-chip system behavior and determining on-chip traffic characteristics. A universal object message level model for SoNoC was defined and an object-oriented methodology was developed to imple-ment this model in hardware and software. The model supports "object to core" synthesis and "function in-voking to network" mapping. A case study of an H.263 system verifies the model and methodology. System prototypes are easily built and on-chip traffic can be observed using the SoNoC model to provide real benchmarks for on-chip network design.

  12. SU-E-P-22: AAPM Task Group 263 Tackling Standardization of Nomenclature for Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Matuszak, M; Feng, M [University of Michigan, Ann Arbor, MI (United States); Moran, J [Univ Michigan Medical Center, Ann Arbor, MI (United States); Xiao, Y [Thomas Jefferson University, Philadelphia, PA (United States); Mayo, C; Miller, R [Mayo Clinic, Rochester, MN (United States); Bosch, W [Washington Univ, Saint Louis, MO (United States); Popple, R [Univ Alabama Birmingham, Birmingham, AL (United States); Marks, L [UNC School of Medicine, Chapel Hill, NC (United States); Wu, Q [Duke University Medical Center, Durham, NC (United States); Molineu, A; Martel, M [UT MD Anderson Cancer Center, Houston, TX (United States); Yock, T [Massachusetts General Hospital, Boston, MA (United States); McNutt, T [Johns Hopkins University, Severna Park, MD (United States); Brown, N [Baptist Medical Center, Jacksonville, FL (United States); Purdie, T [Princess Margaret Hospital, Toronto, ON (Canada); Yorke, E [Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Santanam, L [Washington University School of Medicine, St.louis, MO (United States); Gabriel, P [University of Pennsylvania, Philadelphia, PA (United States); Michalski, J [Washington University, Saint Louis, MO (United States); and others

    2015-06-15

    Purpose: There is growing recognition of need for increased clarity and consistency in the nomenclatures used for body and organ structures, DVH metrics, toxicity, dose and volume units, etc. Standardization has multiple benefits; e.g. facilitating data collection for clinical trials, enabling the pooling of data between institutions, making transfers (i.e. hand-offs) between centers safer, and enabling vendors to define “default” settings. Towards this goal, the American Association of Physicists in Medicine (AAPM) formed a task group (TG263) in July of 2014, operating under the Work Group on Clinical Trials to develop consensus statements. Guiding principles derived from the investigation and example nomenclatures will be presented for public feedback. Methods: We formed a multi-institutional and multi-vendor collaborative group of 39 physicists, physicians and others involved in clinical use and electronic transfer of information. Members include individuals from IROC, NRG, IHE-RO, DICOM WG-7, ASTRO and EORTC groups with overlapping interests to maximize the quality of the consensus and increase the likelihood of adoption. Surveys of group and NRG members were used to define current nomenclatures and requirements. Technical requirements of vendor systems and the proposed DICOM standards were examined. Results: There is a marked degree of inter and intra institutional variation in current approaches, resulting from inter-vendor differences in capabilities, clinic specific conceptualizations and inconsistencies. Using a consensus approach, the group defined optimal formats for the naming of targets and normal structures. A formal objective assessment of 13 existing clinically-used software packages show that all had capabilities to accommodate these recommended nomenclatures. Conclusions: A multi-stakeholder effort is making significant steps forward in developing a standard nomenclature that will work across platforms. Our current working list includes > 550

  13. Biological Characterizations of Scrapie 263K Infected Hamster%羊瘙痒因子263K感染金黄地鼠后生物学特性的检测

    Institute of Scientific and Technical Information of China (English)

    鲁云; 赵德明; 杨利峰

    2011-01-01

    本次研究将感染羊瘙痒因子263K的脑匀浆通过颅内接种于金黄地鼠,应用临床特征观察、组织病理学观察、免疫组织化学观察以及Western blotting等技术对该毒株的生物学特性进行检测,分析和探讨其对金黄地鼠有无致病性以及致病特点,并为国内朊病毒的研究建立263K动物模型.结果表明,根据潜伏期及临床症状、组织病理学特征、免疫组织化学特征和Western blotting检测结果等判断,该毒株在金黄地鼠体内所表现的生物学特性与原毒株基本一致,由此也建立了国内该毒株的金黄地鼠动物研究模型,为进一步深入研究朊病毒疾病打下重要的基础.%In this study, we intracerebrally (IC) inoculated scrapie 263K infected hamster brain homogenate into the healthy hamsters of Chinese breed, the biological characteristics of 263K prion strain were identified by the clinical symptoms,the pathological, immunohistochemical and Western blotting characteristics. Then the 263K prion hamster animal model was established, which is significant for us to study the prion disease in the future in China.

  14. 33 CFR 263.27 - Authority for mitigation of shore damage attributable to navigation works (Section 111).

    Science.gov (United States)

    2010-07-01

    ... Shore Protection Policy § 263.27 Authority for mitigation of shore damage attributable to navigation... and hurricane protection projects. (3) Mitigation of shore damages is defined as the construction of... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Authority for mitigation of...

  15. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples

    NARCIS (Netherlands)

    Rodriguez-Rodriguez, L.; Taib, W.R.; Topless, R.; Steer, S.; Gonzalez-Escribano, M.F.; Balsa, A.; Pascual-Salcedo, D.; Gonzalez-Gay, M.A.; Raya, E.; Fernandez-Gutierrez, B.; Gonzalez-Alvaro, I.; Bottini, N.; Witte, T.J.M. de; Viken, M.K.; Coenen, M.J.H.; Riel, P.L. van; Franke, B.; Heijer, M. den; Radstake, T.R.D.J.; Wordsworth, P.; Lie, B.A.; Merriman, T.R.; Martin, J.

    2011-01-01

    OBJECTIVE: Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the influence of this polymorphism on the risk of rheumatoid arthritis (RA). METHODS: RA patients (n = 5,579) were recruited f

  16. 33 CFR 263.25 - Authority for emergency streambank and shoreline protection of public works and nonprofit public...

    Science.gov (United States)

    2010-07-01

    ... streambank and shoreline protection of public works and nonprofit public services (Section 14). 263.25... and shoreline protection of public works and nonprofit public services (Section 14). (a) Legislative... year, for the construction, repair, restoration, and modification of emergency streambank and...

  17. 49 CFR 40.263 - What happens when an employee is unable to provide a sufficient amount of saliva for an alcohol...

    Science.gov (United States)

    2010-10-01

    ... a sufficient amount of saliva for an alcohol screening test? 40.263 Section 40.263 Transportation... sufficient amount of saliva for an alcohol screening test? (a) As the STT, you must take the following steps if an employee is unable to provide sufficient saliva to complete a test on a saliva screening...

  18. Picosecond Laser Shock Peening of Nimonic 263 at 1064 nm and 532 nm Wavelength

    Directory of Open Access Journals (Sweden)

    Sanja Petronic

    2016-02-01

    Full Text Available The paper presents a study on the surface modifications of nickel based superalloy Nimonic 263 induced by laser shock peening (LSP process. The process was performed by Nd3+:Yttrium Aluminium Garnet (YAG picosecond laser using the following parameters: pulse duration 170 ps; repetition rate 10 Hz; pulse numbers of 50, 100 and 200; and wavelength of 1064 nm (with pulse energy of 2 mJ, 10 mJ and 15 mJ and 532 nm (with pulse energy of 25 mJ, 30 mJ and 35 mJ. The following response characteristics were analyzed: modified surface areas obtained by the laser/material interaction were observed by scanning electron microscopy; elemental composition of the modified surface was evaluated by energy-dispersive spectroscopy (EDS; and Vickers microhardness tests were performed. LSP processing at both 1064 nm and 532 nm wavelengths improved the surface structure and microhardness of a material. Surface morphology changes of the irradiated samples were determined and surface roughness was calculated. These investigations are intended to contribute to the study on the level of microstructure and mechanical properties improvements due to LSP process that operate in a picosecond regime. In particular, the effects of laser wavelength on the microstructural and mechanical changes of a material are studied in detail.

  19. The role of particle ripening on the creep acceleration of Nimonic 263 superalloy

    Directory of Open Access Journals (Sweden)

    Angella Giuliano

    2014-01-01

    Full Text Available Physically based constitutive equations need to incorporate the most relevant microstructural features of materials to adequately describe their mechanical behaviour. To accurately model the creep behaviour of precipitation hardened alloys, the value and the evolution of strengthening particle size are important parameters to be taken into account. In the present work, creep tests have been run on virgin and overaged (up to 3500 h at 800 ∘C Nimonic 263, a polycrystalline nickel base superalloy used for combustion chambers of gas turbines. The experimental results suggest that the reinforcing particle evolution is not the main reason for the creep acceleration that seems to be better described by a strain correlated damage, such as the accumulation of mobile dislocations or the grain boundary cavitation. The coarsened microstructure, obtained by overageing the alloy at high temperature before creep testing, mainly influences the initial stage of the creep, resulting in a higher minimum creep rate and a corresponding reduction of the creep resistance.

  20. 新核素~(263)Hs,~(260)Bh及其α衰变链上核素的半衰期%Half-lives of the newly synthesized nuclei in ~(263)Hs and ~(260)Bh α-decay chains

    Institute of Scientific and Technical Information of China (English)

    苏昕宁; 张鸿飞; 左维; 李君清

    2009-01-01

    The tunneling probability of potential barrier of the newly synthesized superheavy nuclei starting from ~(263)Hs and ~(260)Bh was calculated with the Generalized Liquid Drop Model (GLDM) connected with WKB approximation and their half-lives studied. The calculated results that are in agreement with the experimental data show that the α-decay half-lives of superheavy nuclei with the Generalized Liquid Drop Model connecting with WKB approximation can be successfully, applied in the study of superheavy nuclei and describe the α-decay of superheavy nuclei. The results also indicate that the syntheses of new nuclei ~(260)Bh and ~(263)Hs and the measurements of their α-decay half-lives are reliable.%运用推广的液滴模型(GLDM)并结合量子力学中的WKB方法计算了新核素~(263)Hs,~(260)Bh及其α衰变链上各核素的势垒贯穿概率,对该链上各原子核的α衰变半衰期进行了研究.计算结果表明:利用推广的液滴模型结合WKB方法计算出的α衰变半衰期可以很好地符合在超重核区的实验值,验证了推广的液滴模型在超重核区的适用性,能够很好地描述超重核的α衰变.同时,计算表明新核素~(260)Bh和~(263)Hs的合成及其半衰期的测量是可靠的.

  1. Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression

    Directory of Open Access Journals (Sweden)

    Wei-Jen Ting

    2015-10-01

    Full Text Available Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD, and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD. Scholars have suggested that certain probiotics may significantly impact cardiovascular health, particularly certain Lactobacillus species, such as Lactobacillus reuteri GMNL-263 (Lr263 probiotics, which have been shown to reduce obesity and arteriosclerosis in vivo. In the present study, we examined the potential of heat-killed bacteria to attenuate high fat diet (HFD-induced hepatic and cardiac damages and the possible underlying mechanism of the positive effects of heat-killed Lr263 oral supplements. Heat-killed Lr263 treatments (625 and 3125 mg/kg-hamster/day were provided as a daily supplement by oral gavage to HFD-fed hamsters for eight weeks. The results show that heat-killed Lr263 treatments reduce fatty liver syndrome. Moreover, heat-killed Lactobacillus reuteri GMNL-263 supplementation in HFD hamsters also reduced fibrosis in the liver and heart by reducing transforming growth factor β (TGF-β expression levels. In conclusion, heat-killed Lr263 can reduce lipid metabolic stress in HFD hamsters and decrease the risk of fatty liver and cardiovascular disease.

  2. Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam

    Energy Technology Data Exchange (ETDEWEB)

    Froula, D. H.; Boni, R.; Bedzyk, M.; Craxton, R. S.; Ehrne, F.; Ivancic, S.; Jungquist, R.; Shoup, M. J.; Theobald, W.; Weiner, D. [Laboratory for Laser Energetics, University of Rochester, 250 E. River Rd., Rochester, New York 14616 (United States); Kugland, N. L.; Rushford, M. C. [Lawrence Livermore National Laboratory, University of California, P. O. Box 808, Livermore, California 94551 (United States)

    2012-10-15

    A 10-ps, 263-nm (4{omega}) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution ({approx}1 -{mu}m full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10{sup 4} with respect to all wavelengths outside of the 263 {+-} 2 nm measurement range.

  3. Optical diagnostic suite (schlieren, interferometry, and grid image refractometry) on OMEGA EP using a 10-ps, 263-nm probe beam.

    Science.gov (United States)

    Froula, D H; Boni, R; Bedzyk, M; Craxton, R S; Ehrne, F; Ivancic, S; Jungquist, R; Shoup, M J; Theobald, W; Weiner, D; Kugland, N L; Rushford, M C

    2012-10-01

    A 10-ps, 263-nm (4ω) laser is being built to probe plasmas produced on the OMEGA EP [J. H. Kelly, L. J. Waxer, V. Bagnoud, I. A. Begishev, J. Bromage, B. E. Kruschwitz, T. E. Kessler, S. J. Loucks, D. N. Maywar, R. L. McCrory et al., J. Phys. IV France 133, 75-80 (2006)]. A suite of optical diagnostics (schlieren, interferometry, and grid image refractometry) has been designed to diagnose and characterize a wide variety of plasmas. Light scattered by the probe beam is collected by an f/4 catadioptric telescope and a transport system is designed to image with a near-diffraction-limited resolution (~1 - μm full width at half maximum) over a 5-mm field of view to a diagnostic table. The transport system provides a contrast greater than 1 : 10(4) with respect to all wavelengths outside of the 263 ± 2 nm measurement range.

  4. Effect of Machining Parameters on Surface Integrity in Machining Nimonic C-263 Super Alloy Using Whisker-Reinforced Ceramic Insert

    Science.gov (United States)

    Ezilarasan, C.; Senthil kumar, V. S.; Velayudham, A.

    2013-06-01

    Whisker-reinforced ceramic inserts were used to conduct turning trials on nimonic C-263 super alloy to study the effect of different combinations of cutting parameters on surface integrity (roughness, microhardness, and residual stress) by employing energy dispersive spectroscopy, scanning electron microscopy, x-ray diffraction, and Vicker's microhardness test. Abrasion, adhesion and diffusion were found to be the main tool wear mechanisms in turning nimonic C-263 alloy. Based on characterization of surface roughness, a combination of 190 m/min cutting speed and 0.102 mm/rev feed rate was found to be the critical condition for turning nimonic C-263 alloy. Microhardness varied between 550 and 690 HV at the feed rates of 0.102-0.143 mm/rev for a cutting speed of 250 m/min after 9 min of turning. A tensile residual stress of 725-850 MPa on the machined surface was recorded at the preceding combination of cutting parameters. Cutting speed and cutting time had a dominant effect on the magnitude of the residual stress. No evidence of thermal relaxation and reduction in the degree of work hardening was noted during machining at high cutting speed.

  5. Operable Breast Cancer: a Clinical Analysis of 6,263 Cases

    Institute of Scientific and Technical Information of China (English)

    Mingtian Yang; Xi Wang; Jun Tang; Tiehua Rong; Zhifan Huang; Changuang Zeng; Hao Long; Jianhua Fu; Peng Lin; Xin Wang; Siyu Wang

    2005-01-01

    OBJECTIVE In Europe and America breast cancer commonly occurs in women of middle and old age, with a median age of about 57 years. Modified radical mastectomy now called standard radical mastectomy, has taken the place of traditional radical mastectomy. Patients with breast cancer at an early stage commonly receive BCT (breast conservative therapy). The TNM stage (especially the lymph node status) affects the prognosis, and adjuvant therapy can improve survival. In China, only a few reports have been pubIished studying large numbers of breast cancer patients. This study was designed to analyze the clinical features, surgical pattern and treatment outcome of resectable breast cancer, as well as to explore the prognostic factors and the effect of adjuvant therapy, with a goal to improve the level of diagnosis and treatment.METHODS Records of the 6,263 patients with resectable breast cancer who had been admitted into our hospital from June 1964 to June 2003 were analyzed retrospectively.RESULTS Of the 6,263 cases, 98.8% were female. Breast cancer occurred most frequently in patients of ages 40~49 years (41.0%), especially in patients 45~49 years old (25.2%). A breast lump, which occurred in 96.2% of the patients, was the main clinical manifestation. The overall 5- and 10-year survival rates were 75.16% and 40.44%. Of the patients in TNM stages 0-1,Ⅱ, and Ⅲ, the 5-year survival rates were 96.8%, 73.7% and 46.4% respectively and the 10-year survival rates were 78.7%, 64.6% and 33.5% respectively. The 5-, and 10-year survival rates were higher in the lymph node negative group than in the lymph node positive group (80.3% vs. 55.6%, and 59.2% vs. 31.9%, P<0.01). Since the 1980s there was no significant difference in survival rates of patients who received a radical mastectomy compared to a modified radical mastectomy(P>0.05). Of the 73 patients who underwent breast conservative therapy, no local recurrence or metastasis occurred during a maximal follow-up of 17

  6. Distribution and excretion of N-Ilel Thr2-63-desulfatohirudin in rats

    Institute of Scientific and Technical Information of China (English)

    SU Yun-jiang; GUO Zhu-han

    2008-01-01

    Objective To investigate distribution and excretion of N-Ile1Thr2-63-desulfatohirudin (rH) a recombinant hirudin newly developed in China, in rats for its development as a novel anticoagulant agent. Methods ELISA was used to determine the rH concentration in related tissues and body fluids. Tissues were collected at 15, 60 and 180min respectively, after iv administration of rH 1.0 mg·kg-1 to 3 groups of 5 rats, and homogenized. Urine, bile and feces were collected at pre-selected intervals of time after iv dosing 1.0 mg·kg-1 to 3 groups of 5 rats and assayed. Results rH following iv dosing was distributed rapidly, the rH levels in all tissues being found to be the highest at 15 min post-injection, afterwards gradually reduced. The highest concentration of rH was found in blood, the next in lung and heart, the lowest in brain. With 15 min post dose as an example, the rH contents in tissues were ranked in order of plasmalungheart adipose skeletal muscles kidney liver spleen brain. The 12 h-cumulative excretion amount of rH in urine and feces accounted for 0.03% and 0.001% of administered dose, respectively; the 6 h-cumulative excretion amount in bile was 0.02 % of the dose. Conclusions The rH is distributed mainly in blood circulation system with very low content in other tissues. The drug is excreted from urine, feces and bile of rats in extremely minute amount(only 0.051% dose), suggesting that rH undergoes extensive metabolic elimination in rat body.

  7. Investigation and analysis on unmarried adolescents' psychosomatic symptoms among 263 cases of artificial abortion%未婚人工流产女青年263例心理健康状况调查

    Institute of Scientific and Technical Information of China (English)

    宫雯

    2012-01-01

    Objective To investigate the psychosomatic symptoms of 263 unmarried adolescents cases of artificial abortion. Methods Anonymously issued mental symptom checklist 90 (SCL-90) and self-compiled abortion issues related questionnaires survey. The data were analyzed. Results (1) In addition to the coercion and paranoid, the SCL-90 factor scores were higher in 263 cases of research group than that of normal model on average; the difference showed statistical significance between two groups ( P < 0. 05 ) . The somatization, interpersonal relationship, depression, anxiety, fear and hostility and psychotic scores were higher than those of control group, the difference showed statistical significance (P < 0. 05). (2) Abortion-related questionnaire results showed that 76% of unmarried young women can discover the pregnancy but do not understand the hazards of artificial abortion, 23% of young women lack the necessary contraception and reproductive health knowledge. In 263 cases, 20 percent of young unmarried women underwent artificial abortion for two or more times. Artificial abortion has negative impacts on youth unmarried women' psychosomatic symptoms such as self-blame, fear and anxiety. Conclusion Unmarried pregnancy female' s sexual health and safety knowledge level needs to be improved. Actively carry out reproductive health counseling, implement feasible contraceptive measures is the key to reduce adolescent abortion rates and ensure physical and mental health.%目的 探讨未婚人工流产女青年心理健康状况.方法 以匿名方式发放精神症状自评量表(SCL-90)及自编的流产相关问题问卷调查并分析资料.结果 (1)研究组263例的SCL-90各因子除强迫和偏执以外,其余分值均高于全国常模.两者比较,差异有统计学意义(P<0.05);研究组的躯体化、人际关系、抑郁、焦虑、恐惧和敌对性、精神病性分值高于对照组有统计学意义(P<0.05).(2)流产相关问卷结果显示,76%的未

  8. Establishment of a Stable PrPSc Panel from Brain Tissues of Experimental Hamsters with Scrapie Strain 263K

    Institute of Scientific and Technical Information of China (English)

    BAO-YUN ZHANG; CHAN TIAN; JUN HAN; CHEN GAO; QI SHI; JIAN-MING CHEN; HUI-YING JIANG; WEI ZHOU; XIAO-Ping DONG

    2009-01-01

    Objective To establish a stable PrPSc panel from brain tissues of experimental hamsters infected with scrapie agent 263K for evaluating diagnostic techniques of human and animals' prion diseases. Methods Thirty brain tissue samples from hamsters intracerebrally infected with scrapie strain 263K and another 30 samples from normal hamsters were selected to prepare 10%, 1%, and 0.5% brain homogenates, which were aliquoted into stocks. PrPSc in each brain homogenate was determined by proteinase K digestions followed by Western blot assay and partially by immunohistochemistry. Stability and glycoforms of PrPSc were repeatedly detected by PrPSc-specific Western blots in half a year and 3 years later. Results PrPSc signals were observed in all 10% brain homogenates of infected hamsters. Twenty out of 30 stocks and 19 out of 30 stocks were PrPSc positive in 1% and 0.5% brain homogenatesof infected hamsters, respectively. Twenty-seven out of 30 stocks presented three positive bands in 10% brain homogenates, whereas none of 1% and 0.5% homogenates contained 3 bands. The detection of PrPSc-specific signals stored in half a year and 3 years later demonstrated that the ratio of PrPSc positive samples and glycoforms was almost unchanged. All normal hamsters' brain homogenates were PrPSc negative. Conclusion A PrPSc panel of prion disease can be established, which displays reliably stable PrPSc-specific signals and glycoforms.

  9. Scrapie strain 263K can induce spongiform encephalopathy in golden hamster by intragastrical injection%羊瘙痒因子263K经灌胃感染仓鼠动物模型的建立

    Institute of Scientific and Technical Information of China (English)

    张瑾; 陈岚; 肖新莉; 张宝云; 韩俊; 高建梅; 姜慧英; 刘勇; 董小平

    2005-01-01

    目的胃肠感染是大多数动物类传染性海绵状脑病(TSE)传播的最主要途径.建立羊瘙痒因子263K灌胃感染仓鼠动物模型,并研究其发病特征.方法 Scrapie 263K毒株低剂量和高剂量经灌胃途径接种金黄仓鼠,在终末期取脑组织,用HE染色观察病理变化,免疫组化法检测PrPSc的组织沉积特点,Western blot检测PrPSc分子特征.结果低剂量灌胃组仅一只动物发病,高剂量组所有接种动物均发病,潜伏期较颅内注射组明显延长.在脑组织中观察到典型的病理改变;PrPSc免疫组化检测显示弥漫性沉积于脑组织,主要累及脑干、大脑皮层深层、小脑,基本与病理学改变累及的区域一致;Western Blot检测发现感染动物脑提取物出现可抵抗蛋白酶消化的PrPSc条带,与颅内注射组脑组织提取物中PrPSc电泳性状完全一致.结论羊瘙痒因子263K灌胃可成功引起动物发病,与颅内注射比较,潜伏期、神经病理变化和PrPsc沉积均有不同,可能受到感染途径的影响.

  10. Data on the DNA damaging and mutagenic potential of the BH3-mimetics ABT-263/Navitoclax and TW-37.

    Science.gov (United States)

    Green, Maja M; Shekhar, Tanmay M; Hawkins, Christine J

    2016-03-01

    Unfortunately, the mutagenic activities of chemotherapy and radiotherapy can provoke development of therapy-induced malignancies in cancer survivors. Non-mutagenic anti-cancer therapies may be less likely to trigger subsequent malignant neoplasms. Here we present data regarding the DNA damaging and mutagenic potential of two drugs that antagonize proteins within the Bcl-2 family: ABT-263/Navitoclax and TW-37. Our data reveal that concentrations of these agents that stimulated Bax/Bak-dependent signaling provoked little DNA damage and failed to trigger mutations in surviving cells. The data supplied in this article is related to the research work entitled "Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells" [1].

  11. Numerical simulation for determination of limit strains of a cold rolled and solution treated Nimonic C-263 alloy sheet

    Indian Academy of Sciences (India)

    K Ankamma; P V R Ravindra Reddy; S Nagarjuna; G Chandra Mohan Reddy; M Komaraiah; N Eswara Prasad

    2011-06-01

    Nimonic alloys are Ni-base superalloys used for several high temperature applications, notable among them are the components in space vehicles, rocket engines, submarines, nuclear reactors, chemical processing vessels and heat exchange tubing as they exhibit excellent mechanical strength and creep resistance at high temperatures. Hence, evaluation of their formability characteristics is of utmost importance to make them into several useful components. Limit strains or forming limit curve is one of the parameters that indicates the formability, especially the drawability of sheet metal for deep drawing applications. In this paper, the limit strains of Nimonic C-263 alloy is investigated and presented using an explicit finite element code LSDYNA 3D. The material properties and the material model are evaluated by conducting tensile tests. The limit strains obtained from the simulation are verified by the analytical equations developed using vertex theory. The results tally within ±10% error.

  12. Scrapie Agent (Strain 263K can transmit disease via the oral route after persistence in soil over years.

    Directory of Open Access Journals (Sweden)

    Bjoern Seidel

    Full Text Available The persistence of infectious biomolecules in soil constitutes a substantial challenge. This holds particularly true with respect to prions, the causative agents of transmissible spongiform encephalopathies (TSEs such as scrapie, bovine spongiform encephalopathy (BSE, or chronic wasting disease (CWD. Various studies have indicated that prions are able to persist in soil for years without losing their pathogenic activity. Dissemination of prions into the environment can occur from several sources, e.g., infectious placenta or amniotic fluid of sheep. Furthermore, environmental contamination by saliva, excrements or non-sterilized agricultural organic fertilizer is conceivable. Natural transmission of scrapie in the field seems to occur via the alimentary tract in the majority of cases, and scrapie-free sheep flocks can become infected on pastures where outbreaks of scrapie had been observed before. These findings point to a sustained contagion in the environment, and notably the soil. By using outdoor lysimeters, we simulated a contamination of standard soil with hamster-adapted 263K scrapie prions, and analyzed the presence and biological activity of the soil-associated PrP(Sc and infectivity by Western blotting and hamster bioassay, respectively. Our results showed that 263K scrapie agent can persist in soil at least over 29 months. Strikingly, not only the contaminated soil itself retained high levels of infectivity, as evidenced by oral administration to Syrian hamsters, but also feeding of aqueous soil extracts was able to induce disease in the reporter animals. We could also demonstrate that PrP(Sc in soil, extracted after 21 months, provides a catalytically active seed in the protein misfolding cyclic amplification (PMCA reaction. PMCA opens therefore a perspective for considerably improving the detectability of prions in soil samples from the field.

  13. High spatial resolution optical imaging of the multiple T Tauri system LkH{\\alpha} 262/LkH{\\alpha} 263

    CERN Document Server

    Velasco, S; Oscoz, A; Mackay, C; Labadie, L; Garrido, A Pérez; Crass, J; Díaz-Sánchez, A; Femenía, B; González-Escalera, V; King, D L; López, R L; Puga, M; Rodríguez-Ramos, L F; Zuther, J

    2016-01-01

    We report high spatial resolution i' band imaging of the multiple T Tauri system LkH$\\alpha$ 262/LkH$\\alpha$ 263 obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. AOLI images have provided photometry for each of the two components LkH$\\alpha$ 263 A and B (0.41 arcsec separation) and marginal evidence for an unresolved binary or a disc in LkH$\\alpha$ 262. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkH$\\alpha$ 263 are co-moving, that there is orbital motion in the AB pair, and, remarkably, that LkH$\\alpha$ 262-263 is a common proper motion system with less than 1 mas/yr relative motion. We argue that this is a likely five-component gravitationally bounded system. According to BT-settl models the mass of each of the five components is close to 0.4 M$_{\\odot}$ and the age is in the range 1-2 Myr. The presence of discs...

  14. 43 CFR 30.263 - May a surviving spouse reserve a life estate when a tribe exercises its statutory option to...

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false May a surviving spouse reserve a life... Interests Under Special Statutes § 30.263 May a surviving spouse reserve a life estate when a tribe... tribal purchase option is a surviving spouse, the spouse may reserve a life estate in one-half of...

  15. Comparison Study on Clinical and Neuropathological Characteristics of Hamsters Inoculated With Scrapie Strain 263K in Different Challenging Pathways

    Institute of Scientific and Technical Information of China (English)

    JIN ZHANG; XIAO-BO ZHOU; GUI-PING MA; YONG LIU; CAI-MIN XU; XIAO-PING DONG; LAN CHEN; BAO-YUN ZHAN; JUN HAN; XIN-LI XIAO; HAI-YAN TIAN; BIN-LING LI; CHEN GAO; JIAN-MEI GAO

    2004-01-01

    Objective To understand the infectious characteristics of a hamster-adapted scrapie strain 263K with five different routes of infection including intracerebral (i.c.), intraperitoneal (i.p.),intragastrical (i.g.), intracardiac and intramuscular (i. m.) approaches. Methods Hamsters were infected with crude- or fine-prepared brain extracts. The neuropathological changes, PrPSc deposits,and patterns of PK-resistant PrP were analyzed by HE stain, immunohistochemistry (IHC) assay and Western blot. Reactive gliosis and neuron loss were evaluated by glial fibrillary acidic protein (GFAP)and neuron specific enolase (NSE) specific IHC. Results The animals inoculated in i.m. and i.p.ways with crude PrPSc extracts showed clinical signs at the average incubation of 69.2+-2.8 and 65.5±3.9 days. Inoculation in i.c. and intracardiac ways with fine PrPSc extracts (0.00035 g) caused similar,but relative long incubation of around 90 days. Only oneout of eight hamsters challenged ini.g way with low dosage (0.01 g) became ill after a much longer incubation (185 d), while all animals (4/4)with high dosage (0.04 g) developed clinical signs 105 days postinfection. The most remarkable spongiform degeneration and PrPsc deposits were found in brain stem among the five challenge groups generally. The number of GFAP-positive astrocytes increased distinctly in brain stems in all infection groups, while the number of NSE-positive cells decreased significantly in cerebrum, except i.c. group. The patterns of PK-resistant PrP in brains were basically identical among the five infection routes. Conclusion Typical TSE could be induced in hamsters by inoculating strain 263K in the five infection ways. The incubation periods in bioassays depend on infective dosage, administrating pathway and preparation of PrPSc. The neuropathological changes and PrPSc deposits seem to be related with regions and inoculating pathways.

  16. 改良电痉挛治疗精神病的护理%NURSING CARE OF 263 CASES PSYCHOPATHY TREATD WITH MODIFIED ELECTRIC CONVULSION

    Institute of Scientific and Technical Information of China (English)

    苏勉; 王彩琴; 姚小梅

    2006-01-01

    目的探讨改良电痉挛治疗精神病的护理.方法对263例精神病患者行改良电痉挛治疗(841例次)并进行有效的术前、术中、术后护理.结果263例精神病患者经积极治疗和护理,近期疗效良好,无1例出现严重并发症.结论改良电痉挛疗法是一种安全有效的治疗精神病的方法之一,术后的护理至关重要.

  17. Corrective Action Decision Document/Closure Report for Corrective Action Unit 263: Area 25 Building 4839 Leachfield, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-10-01

    This Corrective Action Decision Document/Closure Report (CADD/CR) has been prepared for Corrective Action Unit (CAU) 263, Area 25 Building 4839 Leachfield, in accordance with the Federal Facility Agreement and Consent Order. Corrective Action Unit 263 is located in the southwestern part of the Nevada Test Site in Nevada and includes one Corrective Action Site (CAS), CAS 25-05-04 Leachfield. This CADD/CR identifies and rationalizes the U.S. Department of Energy, Nevada Operations Office's (DOE/NV's) recommendation that no corrective action for CAU 263 is necessary. The Corrective Action Decision Document and Closure Report have been combined into one report because sample data collected during the April 1999 corrective action investigation (CAI) disclosed no evidence of contamination at the site. The purpose of the CAI was to identify the presence and the vertical and lateral extent of contaminants of potential concern (COPCs), specifically volatile organic compounds (VOCs) and semivola tile organic compounds (SVOCs) such as 1,4-dichlorobenzene and p-isopropyl toluene. The subsequent investigation included direct-push environmental soil samples from within the leachfield using a Geoprobe{reg_sign} unit; field screening of soil samples for radiological constituents and VOCs; submittal of environmental and quality control samples for testing for total VOCs, total SVOCs, and gamma spectrometry; and collection of soil samples from both the liquid phase and the underlying sludge of the septic tank contents. The CAI activities determined that: (1) all total VOC and total SVOC results were below the preliminary action levels outlined in the Corrective Action Investigation Plan (CAIP), and (2) radiological results were not distinguishable from background concentrations identified in the CAIP. Therefore, the DOE/NV recommended that no corrective action was required at CAU 263. No use restrictions were required to be placed on the CAU because the investigation

  18. Impact toughness of ternary Al–Zn–Mg alloys in as cast and homogenized condition measured in the temperature range 263–673 K

    Indian Academy of Sciences (India)

    Harish Kundar; Krishna; K Srinivasan

    2000-02-01

    Impact toughness of six Al–Zn–Mg ternary alloys are compared with two Al–Zn binary alloys and one CP aluminium metal at eight different temperatures of 263, 268, 273, 300, 373, 473, 573 and 673 K. The effects of alloying and temperature on toughness have been compared and analysed. The influence of alloying is more pronounced than that of temperature in reducing the toughness.

  19. Microarray based analysis of an inherited terminal 3p26.3 deletion, containing only the CHL1 gene, from a normal father to his two affected children

    Directory of Open Access Journals (Sweden)

    Lerone Margherita

    2011-04-01

    Full Text Available Abstract Background terminal deletions of the distal portion of the short arm of chromosome 3 cause a rare contiguous gene disorder characterized by growth retardation, developmental delay, mental retardation, dysmorphisms, microcephaly and ptosis. The phenotype of individuals with deletions varies from normal to severe. It was suggested that a 1,5 Mb minimal terminal deletion including the two genes CRBN and CNTN4 is sufficient to cause the syndrome. In addition the CHL1 gene, mapping at 3p26.3 distally to CRBN and CNTN4, was proposed as candidate gene for a non specific mental retardation because of its high level of expression in the brain. Methods and Results we describe two affected siblings in which array-CGH analysis disclosed an identical discontinuous terminal 3p26.3 deletion spanning less than 1 Mb. The deletion was transmitted from their normal father and included only the CHL1 gene. The two brothers present microcephaly, light mental retardation, learning and language difficulties but not the typical phenotype manifestations described in 3p- syndrome. Conclusion a terminal 3p26.3 deletion including only the CHL1 gene is a very rare finding previously reported only in one family. The phenotype of the affected individuals in the two families is very similar and the deletion has been inherited from an apparently normal parent. As already described for others recurrent syndromes with variable phenotype, these findings are challenging in genetic counselling because of an evident variable penetrance.

  20. Desempeño del modelo rothc-26.3 a nivel de parcela en México

    Directory of Open Access Journals (Sweden)

    Lucila González Molina

    2016-07-01

    Full Text Available De acuerdo con el Panel Intergubernamental sobre el Cambio Climático (PICC, deben reportarse los almacenes y cambios del carbono orgánico del suelo (COS en el tiempo. El modelo RothC-26.3 (RothC es uno de los más usados en el mundo para estudiar la dinámica del C en diferentes sistemas. Se evaluó el desempeño del RothC en la simulación de los cambios del COS, a nivel de parcela, en experimentos de corta duración. Se evaluaron nueve sitios y los sistemas: agrícola con residuos vegetales (A+R, agrícola sin residuos (A-R, forestales (F, praderas (PR y agostaderos (AGOS. Las parcelas experimentales se ubicaron en los estados de México, Tlaxcala, Michoacán, Guanajuato, Oaxaca, Jalisco y Nuevo León. El RothC se ejecutó (i con el COSinicial, medido en cada punto de muestreo (*CIPUN en parcelas de la Sierra Norte de Oaxaca y, (ii con el COSinicial promedio medido por parcela (*CIPAR en el resto de los sitios. Se midieron y estimaron los parámetros de entrada al modelo, como residuos vegetales y abonos orgánicos. El grado de asociación entre el COS medido y el simulado fue de 0.76 y hasta 1.0 en todos los sitios. La eficiencia del modelo (EF varió entre 0.53 y 0.93, excepto en el Batán, donde se evaluaron sistemas de labranza (EF= −0.60. La r, en ambas formas de simulación, varió entre 0.63 y 0.97, excepto en AGOS; EF en los agrícolas fue de 0.48 a 0.84 y de 0.81 en F *CIPAR. La EF fue insatisfactoria obtenida para los AGOS (*CIPAR y forestales y praderas (*CPUN. Considerando los resultados de los sitios y sistemas y, la forma de simulación *CIPAR, el modelo RothC se puede usar con buena aceptación para simular los cambios de COS a nivel de parcela en los sistemas agrícolas y forestales, mediana en praderas y baja en agostaderos.

  1. Modificación legislativa en materia de seguros en la República de Cuba. Comentarios al Decreto-Ley 263

    OpenAIRE

    Vigil Iduate, Alejandro; Universidad de La Habana

    2009-01-01

    Recién firmado el Decreto-Ley 263, del Contrato de Seguro, el que realiza una modificación sustancial en la legislación cubana al derogar lo establecido en la materia, en el Código Civil y Código de Comercio, y recoge los principios fundamentales del seguro, adecuando la legislación a las nuevas condiciones existentes en la República de Cuba, atemperada a las nuevas concepciones y corrientes doctrinales que refuerzan la función social del seguro. Se impone una primera aproximación a la normat...

  2. Preliminary development plan of the ALR, the laser rangefinder for the ASTER deep space mission to the 2001 SN263 asteroid

    Directory of Open Access Journals (Sweden)

    Antonio Gil Vicente de Brum

    2011-09-01

    Full Text Available The Brazilian deep space mission ASTER, as temporarily named, plans to send a small spacecraft to encounter and investigate the triple asteroid 2001-SN263. The launch is scheduled (initially to occur in 2015, arriving in 2018. The main motivation of the mission is the development of technology and expertise to leverage the national space sector. Within the scientific goals, the investigation of the still unknown asteroid 2001-SN263. The main project guideline is to aggregate the widest possible Brazilian involvement in the platform, the development and operation of subsystems, integration, payload, as well as in the tracking, navigation, guidance and control of the probe. To meet this guideline, among others, the decision for the development of a laser altimeter in Brazil to fly in the mission was taken. This effort is currently coordinated by a group of researchers from the aerospace engineering personnel of UFABC. This article presents the preliminary development plan for the design of this instrument, which was called ALR (ASTER Laser Rangefinder.

  3. Treatment of Scrapie Pathogen 263K With Tetracycline Partially Abolishes Protease-resistant Activity in vitro and Reduces Infectivity in vivo

    Institute of Scientific and Technical Information of China (English)

    YAN-JUN GUO; DE-XIN WANG; XIAO-PING DONG; JUN HAN; HAI-LAN YAO; BAO-YUN ZHANG; JIAN-MEI GAO; JIN ZHANG; XIN-LI XIAO; XIAO-FAN WANG; WEI-QIN ZHAO

    2007-01-01

    Objective To study the possible effect of tetracycline on protease-resistant activity in vitro and infectivity in vivo of a scrapie strain 263K.Methods Scrapie pathogens were incubated with tetracycline at different concentrations for various periods of time and protease-resistant PrP signals were evaluated with proteinase K-treatment and Western blots.The preparations treated with tetracycline were intracerebrally inoculated into golden hamsters and typical TSE manifestations were noted.PrPSc in brain tissues of the infected animals was detected by PrP specific Western blot assays. Results Protease-resistant PrP was significantly reduced in or removed from the preparations treated with tetracycline in a dose-dependant manner.Compared with the control group after incubated for 53.75±0.50 days,the preparations treated with 5 mmol/L and 20 mmol/L tetracycline prolonged the incubation time of 61.5±1.73 and 59.5±0.58 days (P<0.05). Conclusion Treatment of scrapie pathogen 263K with tetracycline reduces or removes its protease-resistant activity in vitro.

  4. Dynamic Analyses of PrP and PrPsc in Brain Tissues of Golden Hamsters Infected With Scraple Strain 263K Revealed Various PrP Forms

    Institute of Scientific and Technical Information of China (English)

    JIAN-MEI GAO; AND XIAO-PING DONG; CHEN GAO; JUN HAN; XIAO-BO ZHOU; XIN-LI XIAO; JIN ZHANG; LAN CHEN; BAO-YUN ZHANG; TAO HONG

    2004-01-01

    Objective To expatiate dynamic changes in hamsters infected with scrapie strain 263K, to observe the presence and aggravation of various forms of PrP and PrPSc during incubation period, and to probe primarily the relationship between the onset of clinic manifestations and the presence of different PrPSc forms. Methods Hamster-adapted scrapie strain 263K was intracerebrally inoculated into hamsters. Different forms of PrP and PrPSc were monitored dynamically by Western blot and immuno-histochemical assays. The presence of scrapie-associated fibril (SAF) was assayedby electron microscopy analysis (EM) and immuno-golden EM. Results PrPSc was initiallydetected in the brain tissues of the animals in 20 days post-inoculation by immunohistochemistry and 40 days with Western blot. Quantitative evaluations revealed that the amounts of PrP and PrPSc inbrain tissues increased along with the incubation. Several high and low molecular masses of PrP wereseen in the brains of the long-life span infected animals. Deglycosylation assays identified that the truncated PrP in the infected brains showed similar glycosylation patterns as the full-length PrP. The presence of short fragments was seemed to relate with the onset of clinical conditions. Conclusion These results indicate that infectious agents exist and accumulate in central nerve system prior to the onset of the illness. Various molecular patterns of PrPSc may indwell in brain tissues during the infection.

  5. Characterization of a balanced complex chromosomal rearrangement carrier ascertained through a fetus with dup15q26.3 and del5p15.33: case report.

    Science.gov (United States)

    Lledo, Belen; Ortiz, Jose Antonio; Morales, Ruth; Manchon, Irene; Galan, Francisco; Bernabeu, Andrea; Bernabeu, Rafael

    2013-09-01

    Complex chromosomal rearrangements (CCRs) are structural aberrations involving more than two chromosomes which rarely appear in individuals with normal phenotypes. These individuals report fertility problems, recurrent miscarriages, or congenital anomalies in newborn offspring as a consequence of either meiotic failure or imbalanced chromosome segregation. A CCR involving chromosomes 5, 15, and 18 was discovered in a phenotypically normal man through a fetus with congenital malformations and partial trisomy of chromosome 15 and monosomy of chromosome 5. Ultrasound examination at 20 weeks of gestation showed severe oligoamnios and hydrothorax. Prenatal cytogenetic analysis and array comparative genomic hybridization (array-CGH) revealed a female fetus with dup15q26.3 and del5p15.33. We diagnosed the CCR using three-color fluorescence in situ hybridization (three-color FISH), and a balanced CCR using array-CGH and FISH was diagnosed in the paternal karyotype. The father is a carrier of a balanced translocation 46,XY,t(5;15;18)(p15.31;q26.3;p11.2). Due to the complexity of these rearrangements the diagnosis is difficult and the reproductive outcome uncertain. Reporting such rare cases is important to enable such information to be used for genetic counseling in similar situations and help estimate the risk of miscarriage or of newborns with congenital abnormalities.

  6. 263名武汉市学龄前儿童膳食结构调查分析%A Survey on Diet Structure of 263 Preschool Children in Wuhan City

    Institute of Scientific and Technical Information of China (English)

    刘毅; 陈婷; 周畅; 李慕君; 蔡华

    2016-01-01

    Objectives To understand diet structure of preschool children in Wuhan City. Methods 2 6 3 children of 3-to 6-year-old in Wuhan City were selected by means of cluster random sampling,and a self-prepared questionnaire was used to learn about children,family,social environment and diet structure and habit and the questionnaire survey was conducted among parents and children respectively.Results The diet structure of preschool children was not scientific,and their top eight favorite foods were yogurt,cake,chocolate,bread,banana,ice cream,apple and milk,the preference rate were 92.78%,92.02%,91.63%,90.1 1%,86.69%,86.31%,86.31% and 84.41% respective-ly.Their least favorite foods were bitter gourd,onion,eggplant,pork liver,celery and lentinus edodes and the prefer-ence rate were 1 9.01%,38.78%,46.39%,50.1 9%,57.79% and 58.94% respectively.For the children of different age group,there was a statistically significant difference in the preference rate to yogurt,eggs,carrot,pear,pork,sea-food,barbecue,pork liver,onion,pickled vegetables,bitter gourd(P <0.05).Girls preferred apple and pear more than boys(P were 0.03 and 0.02),and boys preferred candy,instant noodles and pork liver more than girls(P were 0.01, 0.01 and 0.04 respectively.).Logistic regression analysis showed that parents receiving diet training,family eating habits,mother’s diet structure during pregnancy,complementary food type,children with allergic constitution,and time of watching television were risk factors for children’s loving pork liver,carrot,onion,bitter gourd,drinks,west-ern fast food,seafood and candy.Conclusions At present,preschool children in Wuhan City have problems in diet structure,which should arouse concern from society,family and child health care workers.%目的:了解武汉市学龄前儿童的膳食结构。方法随机整群抽取武汉市263名3~6岁儿童,采用自拟的儿童家庭社会环境与膳食结构及习惯调查问卷,分别对家长及儿童进行问

  7. Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199.

    Directory of Open Access Journals (Sweden)

    Carolina Paola García

    Full Text Available Human embryonic stem cells (hESCs are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by comparing the DNA damage responses triggered by the topoisomerase I inhibitor camptothecin, in hESCs, human induced pluripotent stem cells (hiPSCs and hESCs-derived neuroprogenitors (NP. We observed that upon camptothecin exposure pluripotent stem cells underwent apoptosis more swiftly and at a higher rate than differentiated cells. However, the cellular response encompassing ataxia-telangiectasia mutated kinase activation and p53 phosphorylation both on serine 15 as well as on serine 46 resulted very similar among the aforementioned cell types. Importantly, we observed that hESCs and hiPSCs express lower levels of the anti-apoptotic protein Bcl-2 than NP. To assess whether Bcl-2 abundance could account for this differential response we treated cells with ABT-263, WEHI-539 and ABT-199, small molecules that preferentially target the BH3-binding pocket of Bcl-xL and/or Bcl-2 and reduce their ability to sequester pro-apoptotic factors. We found that in the absence of stress stimuli, NP exhibited a higher sensitivity to ABT- 263 and WEHI-539 than hESCs and hiPSCs. Conversely, all tested cell types appeared to be highly resistant to the Bcl-2 specific inhibitor, ABT-199. However, in all cases we determined that ABT-263 or WEHI-539 treatment exacerbated camptothecin-induced apoptosis. Importantly, similar responses were observed after siRNA-mediated down-regulation of Bcl-xL or Bcl-2. Taken together, our results suggest that Bcl-xL contrary to Bcl-2 contributes to ensure cell survival and also functions as a primary suppressor of DNA double-strand brake induced apoptosis both in pluripotent and derived NP cells. The emerging knowledge of the relative dependence of pluripotent and progenitor cells on Bcl-2 and Bcl-xL activities may help

  8. Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199

    Science.gov (United States)

    Dimopoulos, Nicolás Alexis; Fernandez Espinosa, Damián Darío; Miriuka, Santiago Gabriel; Sevlever, Gustavo Emilio; Romorini, Leonardo; Scassa, María Elida

    2016-01-01

    Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by comparing the DNA damage responses triggered by the topoisomerase I inhibitor camptothecin, in hESCs, human induced pluripotent stem cells (hiPSCs) and hESCs-derived neuroprogenitors (NP). We observed that upon camptothecin exposure pluripotent stem cells underwent apoptosis more swiftly and at a higher rate than differentiated cells. However, the cellular response encompassing ataxia-telangiectasia mutated kinase activation and p53 phosphorylation both on serine 15 as well as on serine 46 resulted very similar among the aforementioned cell types. Importantly, we observed that hESCs and hiPSCs express lower levels of the anti-apoptotic protein Bcl-2 than NP. To assess whether Bcl-2 abundance could account for this differential response we treated cells with ABT-263, WEHI-539 and ABT-199, small molecules that preferentially target the BH3-binding pocket of Bcl-xL and/or Bcl-2 and reduce their ability to sequester pro-apoptotic factors. We found that in the absence of stress stimuli, NP exhibited a higher sensitivity to ABT- 263 and WEHI-539 than hESCs and hiPSCs. Conversely, all tested cell types appeared to be highly resistant to the Bcl-2 specific inhibitor, ABT-199. However, in all cases we determined that ABT-263 or WEHI-539 treatment exacerbated camptothecin-induced apoptosis. Importantly, similar responses were observed after siRNA-mediated down-regulation of Bcl-xL or Bcl-2. Taken together, our results suggest that Bcl-xL contrary to Bcl-2 contributes to ensure cell survival and also functions as a primary suppressor of DNA double-strand brake induced apoptosis both in pluripotent and derived NP cells. The emerging knowledge of the relative dependence of pluripotent and progenitor cells on Bcl-2 and Bcl-xL activities may help to predict

  9. Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2----q26.3.

    Science.gov (United States)

    Astrin, K H; Warner, C A; Yoo, H W; Goodfellow, P J; Tsai, S F; Desnick, R J

    1991-05-01

    Uroporphyrinogen III synthase [UROS; hydroxymethylbilane hydro-lyase (cyclizing), EC 4.2.1.75] is the fourth enzyme in the human heme biosynthetic pathway. The recent isolation of the cDNA encoding human UROS facilitated its chromosomal localization. Human UROS sequences were specifically amplified by the polymerase chain reaction (PCR) from genomic DNA of two independent panels of human-rodent somatic cell hybrids. There was 100% concordance for the presence of the human UROS PCR product and human chromosome 10. For each of the other chromosomes, there was 19%-53% discordance with human UROS. The chromosomal assignment was confirmed by Southern hybridization analysis of DNA from somatic cell hybrids with the full-length UROS cDNA. Using human-rodent hybrids containing different portions of human chromosome 10, we assigned the UROS gene to the region 10q25.2----q26.3.

  10. Automated Microwave Complex on the Basis of a Continuous-Wave Gyrotron with an Operating Frequency of 263 GHz and an Output Power of 1 kW

    Science.gov (United States)

    Glyavin, M. Yu.; Morozkin, M. V.; Tsvetkov, A. I.; Lubyako, L. V.; Golubiatnikov, G. Yu.; Kuftin, A. N.; Zapevalov, V. E.; V. Kholoptsev, V.; Eremeev, A. G.; Sedov, A. S.; Malygin, V. I.; Chirkov, A. V.; Fokin, A. P.; Sokolov, E. V.; Denisov, G. G.

    2016-02-01

    We study experimentally the automated microwave complex for microwave spectroscopy and diagnostics of various media, which was developed at the Institute of Applied Physics of the Russian Academy of Sciences in cooperation with GYCOM Ltd. on the basis of a gyrotron with a frequency of 263 GHz and operated at the first gyrofrequency harmonic. In the process of the experiments, a controllable output power of 0 .1 -1 kW was achieved with an efficiency of up to 17 % in the continuous-wave generation regime. The measured radiation spectrum with a relative width of about 10 -6 and the frequency values measured at various parameters of the device are presented. The results of measuring the parameters of the wave beam, which was formed by a built-in quasioptical converter, as well as the data obtained by measuring the heat loss in the cavity and the vacuum output window are analyzed.

  11. Numerical simulation for the determination of the limit drawing ratio of a cold rolled and solution treated Nimonic C-263 alloy sheet

    Energy Technology Data Exchange (ETDEWEB)

    Ankamma, Kandula; Chandra Mohan Reddy, Gangireddy [Mahatma Gandhi Institute of Technology, Hyderabad (India). Mechanil Engineering Dept.; Rama Ravindra Reddy, Pidugu Venkata [Chaitanya Bharathi Institute of Technology, Hyderabad (India). Mechanical Engineering Dept.; Nagarjuna, Settivari [Defence Metallurgical Research Lab., Hyderabad (India); Komaraiah, Methuku [Malla Reddy College of Engineering and Technology, Secunderabad (India); Eswara Prasad, Namburi [Regional Centre for Military Airworthiness (Materials), Hyderabad (India)

    2011-03-15

    Nimonic alloys are Ni-based superalloys used for several high temperature applications, notable among them are components in space vehicles, rocket engines, submarines, nuclear reactors, chemical processing vessels and heat exchange tubing, as they exhibit excellent mechanical strength and creep resistance at high temperatures. Hence, evaluation of their formability characteristics is of the utmost importance in making them into several useful components. The limit drawing ratio is one of the parameters that indicate the formability, especially the drawability of sheet material for deep drawing applications. In this paper, the limit drawing ratio of Nimonic C-263 alloy is investigated and presented using an explicit finite element code LSDYNA-3D. The material properties and the material model are evaluated through tensile testing. (orig.)

  12. In-plane anisotropy in tensile deformation and its influence on the drawability of Nimonic C–263 alloy sheets

    Indian Academy of Sciences (India)

    K Ankamma; D V V Satyanarayana; G Chandramohan Reddy; M Komaraiah; N Eswara Prasad

    2011-04-01

    An effort has been made to comprehensively evaluate and rationalize the in-plane anisotropy in tensile properties and the effect of aging on the nature of deformation (strain hardening behaviour) and formability characteristics, especially the limit drawing ratio and forming limit diagram. Despite weak crystallographic texture and excellent ductility and high work hardening exponents, the alloy sheets of C-263 exhibit significant extent of in-plane anisotropy in its tensile properties and yield loci. The absolute magnitudes of yield stress and the exact nature of anisotropy that can be predicted from the tensile part of the yield locus need to be employed with caution. This is because when the magnitudes of the yield stresses, obtained from yield locus are more than 5 times higher as compared to the yield and ultimate tensile strength values and the nature and degree of in-plane anisotropy under tensile loading matches with that of only the compressive yield stresses of yield locus. The alloy sheet, due to weak crystallographic texture and relatively high strengths, is found to be far more suitable for structural applications, rather than for deep drawing applications, which was reflected in low limit drawing ratio values (1.34 for CR+ST and 1.23 for peak aged conditions). Further, the study conducted reveals that the safer forming limits in strain space is higher for CR+ST condition; while, the safer forming limits in stress space are higher for peak aged (CR+ST+1073 K/8 h) condition. Finally, detailed studies are outlined to arrive at suitable microstructural and textural characteristics that provide significantly enhanced drawability in the Nimonic C-263 alloy sheets.

  13. 263~373 K温度区间2-氯-3,3,3-三氟丙烯饱和蒸气压的实验研究%Measurement of Saturated Vapor Pressure of 2-Chloro-3,3,3-Trifluoropropene at 263~373 K

    Institute of Scientific and Technical Information of China (English)

    张伟; 杨志强; 吕婧; 吕剑

    2014-01-01

    Saturated vapor pressures of 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf) were measured in a temperature range of 263.15~372.90 K by a static method. A total of 97 experimental points were obtained. The temperature and pressure fluctuation were within 2 mK and 1.2 kPa, respectively. The measured saturated vapor pressures and temperature were correlated by Antoine equation lnP=A-B/(T+C), and the constants of the equation were determined as A=15.119, B=3070.575 and C=7.198. The relative deviations between the calculated results from the Antoine equation and the experimental data are less than ±1%. The average molar evaporation heat of HCFO-1233xf was also estimated at 263.15~372.90 K by Clausius-Clapeyron equation which is 24363.31 J⋅mol-1. The normal boiling point is 285.22 K calculated from the Antoine equation.%采用静态法,测定了2-氯-3,3,3-三氟丙烯(HCFO-1233xf)的饱和蒸气压97个数据点,温度263.15~372.90 K,温度不确定度小于±2 mK,压力不确定度小于±1.2 kPa,并用 Antoine 方程 lnP=A-B/(T+C)进行关联,确定了蒸气压方程的三个参数 A、B、C 的值分别为15.119、3070.575和7.198。Antoine方程计算得到的饱和蒸气压与实验数据吻合较好,相对误差均在±1%以内。通过 Clausius-Clapeyron方程计算得到 HCFO-1233xf 在263.15~372.90 K 的平均摩尔蒸发热为24363.31 J⋅mol-1,通过 Antoine 方程计算得到的常压沸点为285.22 K。

  14. 不同剂量羊瘙痒因子263K颅内感染仓鼠临床终末期脑中GFAP表达的研究%Analyses of the expressions of GFAP in the brain tissues of hamsters infected with various amounts of scrapie strain 263K at terminal stage

    Institute of Scientific and Technical Information of China (English)

    田婵; 张宝云; 石琦; 韩俊; 高晨; 韩露; 董小平

    2008-01-01

    Objective To investigate whether gliosis in the brain tissues of the hamsters infected with various amounts of scrapie strain 263K is correlated with the inoculation doses or the incubation times. Methods The total values of glial fibrillary acidic protein (GFAP) in brains were evaluated by Western Blots and the GFAP-stained cells were detected by immunohistochemistry (IHC). The characteristics of GFAP distributions among various groups were defined by quantitive and statistic analyses. Results Compared with the brain tissues of normal hamsters, remarkably higher total GFAP levels and more GFAP-stained cells were observed in the brain tissues of infected ones, howbeit, no significant difference was addressed among the infected groups. Conclusion Inoculations of various amounts of scrapie strain 263K into experimental hamsters intracerebrally induced the similar patterns of gliosis in the brains at the clinically terminal stage, regardless of infectious doses and incubation times.%目的 研究不同剂量羊瘙痒因子263 K经颅内注射感染仓鼠后,在发病的终末期星形胶质细胞增生程度是否与注射剂量及潜伏期长短有关.方法 以胶质纤维酸性蛋白(glial fibrill aryacidic protein,GFAP)作为星形胶质细胞增生的分子标志物,采用Western Blot和免疫组化方法检测感染仓鼠终末期脑匀浆和脑组织病理切片中的GFAP表达,经定量分析比较各感染剂量组间是否存在差异.结果与正常对照相比,不同剂量感染仓鼠发病终末期脑组织GFAP阳性细胞数量和总GFAP含量均明显升高,但各感染剂量组间无显著差异.结论 不同感染剂量羊瘙痒因子263K经颅内注射感染仓鼠在发病终末期脑中星形胶质细胞的增生程度相似,与感染剂量及潜伏期无关联性.

  15. Fabrication of High Transparency Diamond-Like Carbon Film Coating on D263T Glass at Room Temperature as an Antireflection Layer

    Directory of Open Access Journals (Sweden)

    Chii-Ruey Lin

    2013-01-01

    Full Text Available This study intends to deposit high transmittance diamond-like carbon (DLC thin films on D263T glass substrate at room temperature via a diamond powder target using the radio frequency (RF magnetron sputtering technique. Moreover, various process parameters were used to tune the properties of the thin films by using the Taguchi method. Experimental results show that the content of sp3 bonded carbon decreases in accordance with the effect of the substrate temperature. In addition, the hardness of all as-deposited single-layer DLC films ranges from 13.2 to 22.5 GPa, and the RMS surface roughness was improved significantly with the decrease in sputtering pressure. The water repellent of the deposited DLC films improved significantly with the increase of the sp3 content, and its contact angle was larger than that of the noncoated one by 1.45 times. Furthermore, the refraction index (n of all as-deposited DLC films ranges from 1.95 to 2.1 at λ = 600 nm. These results demonstrate that the thickness increased as the reflectance increased. DLC film under an RF power of 150 W possesses high transmissive ability (>81% and low average reflectance ability (<9.5% in the visible wavelengths (at λ = 400–700 nm.

  16. Pharmacokinetic study with N-Ile1-Thr2-63-desulfato-r-hirudin in rabbits by means of bioassay

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Aim: To study the pharmacokinetic (PK) properties in rabbits treated with N-Ile1-Thr2-63-desulfato-r-hirudin (rH) newly developed in China by means of bioassay in order to provide preclinical experiment basis for its development as a novel anticoagulant agent. Methods: rH plasma concentration was determined using bioassay based on ex vivo antithrombin activity of rH. Normal rabbits received iv rH 4.0, 2.0 and 1.0 mg/kg or sc rH 2.0 mg/kg, respectively. The rabbits with acute severe renal failure were given iv rH 2.0 mg/kg. Results: The bioassay described in this paper met requirements for study of PK in rabbits. The major PK parameters after iv dosing were as follows: t1/2β 58.4~59 min. Vd 0.09~0.12 L/kg, CL 0.0035~0.0040 L/(kg.min);AUC were proportional to the doses, t1/2 and CL did not change significantly with the doses. The sc bioavailability reached 94%. The rabbits suffering from acute severe renal failure presented 11-fold longer t1/2β and 13 -fold greater A UC than normal healthy rabbits.Conclusion: rH exhibited rapid elimination, distribution was only limited to extracellular space and good absorption from sc site.The excretion ofrH by kidneys played a very important role in the elimination of rH. The PK ofrH could be described by the twoand one-compartment model after iv and sc dosing, respectively, and followed linear kinetics.

  17. Biological, chemical and other data collected aboard the THOMAS G. THOMPSON during cruise TN263 in the Coastal Waters of SE Alaska, Gulf of Alaska and North Pacific Ocean from 2011-04-30 to 2011-05-21 (NODC Accession 0117409)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0117409 includes biological, chemical, optical and physical data collected aboard the THOMAS G. THOMPSON during cruise TN263 in the Coastal Waters of...

  18. Analysis of The Expressions of αB-crystallin in The Brain Tissues of Agent 263K-infected Hamsters at Terminal Stage%羊瘙痒因子263K感染仓鼠临床终末期脑中αB-晶体蛋白表达的研究

    Institute of Scientific and Technical Information of China (English)

    王轲; 任科; 燕玉娥; 王荟; 张宝云; 刘勇; 董小平; 张瑾

    2013-01-01

    αB-crystallin is a member of the sHSP (Small heat shock protein) family, which plays an important role in multiple neurodegeneration diseases. To give insight into the possible alternation and the role of αB-crystallin in prion disease, the αB-crystallin levels in the brain tissues of agent 263K-infected hamsters were evaluated. Western blots and IHC revealed that at the terminal stages of the diseases, the levels of αB-crystallin were increased up to 3-fold in the brain tissues of scrapie infected 263K hamsters compared with normal controls. Immunofluorescent assays revealed that the up-regulated αB-crystallin was mainly observed in astrocytes, but not in neurons. The co-localization between αB-crystallin and abnormal deposition of PrPSc in the brain tissues of the scrapie infected hamsters was not observed. The study may provide a foundation for further revealing the potential role of αB-crystallin in prion disease.%αB-晶体蛋白(αB-crystallin)是小热休克蛋白(Small heat shock protein,sHSP)家族的代表成员,已发现与多种神经退行性疾病发生发展密切相关,但至今为止对αB-晶体蛋白在朊病毒病发生发展中可能扮演的角色研究甚少,作用尚不清楚.本研究利用羊瘙痒因子仓鼠敏感株263K感染仓鼠建立的朊病毒实验动物模型,通过免疫印迹(Western blots)和免疫组织化学染色观察到伴随PrPSc在感染终末期动物脑组织中大量沉积,αB-晶体蛋白表达显著上调,比正常对照增高3倍.免疫荧光双染确定其分布的主要细胞类型为星形胶质细胞,神经元中未检测到表达.感染动物中高表达的αB-晶体蛋白与异常沉积的PrPSc无明显共定位.此研究为进一步探讨和揭示αB-晶体蛋白在朊病毒病中可能的作用和分子机制奠定了基础.

  19. 一些化学和物理因素对羊瘙痒因子263K蛋白酶抗性的影响%Effects of Several Chemical and Physical Treatments on the Protease Resistance of Scrapie Strain 263K

    Institute of Scientific and Technical Information of China (English)

    姚海兰; 韩俊; 张宝云; 高建梅; 郭燕军; 张瑾; 肖新莉; 聂凯; 蔡昌学; 董小平

    2004-01-01

    朊病毒(prion)具有超强的理化因素抵抗能力,可抵抗常规物理和化学因子对其感染性的灭活.为了研究不同理化因素对PrPSc蛋白酶抗性的影响,采用不同浓度的NaOH、NaOCl、SDS、温度变化以及3%SDS与温度变化联合处理羊瘙痒因子263K,再经蛋白酶K(Proteinase K,PK)消化,通过Western blot检测观测PrPSc的PK抗性.结果发现,上述几种理化因素对羊瘙痒因子263K的PK抗性有不同程度的破坏作用.NaOH浓度在0.05mol/L以上,NaOCl游离氯含量在0.1%以上,温度在121℃以上都能使PrPSc的PK抗性消失;而1%~5%SDS不能使PrPSc的PK抗性完全消失,3%SDS与温度的联合作用可有效地破坏PK抗性,同时使所需温度降低.还发现,在较低浓度的化学因子或温度的条件下即可出现PK抗性的破坏,而在较高浓度或温度处理时才出现蛋白本身的消失.这些结果提示,与PrPSc感染性的结果相似,PK抗性可受相似浓度或强度的理化因素影响,具有明显的浓度或强度相关性,对判定消除PrPSc的感染性有一定的指导意义.

  20. Heterogeneity of PrP in Brains of Hamsters Infected with Scrapie 263K Strain and the Dynamic Detection by Western blot%羊瘙痒病263K毒株感染的仓鼠脑中PrP分子形式多样性的动态测定

    Institute of Scientific and Technical Information of China (English)

    高建梅; 高晨; 周晓勃; 张瑾; 韩俊; 张宝云; 董小平

    2003-01-01

    正常细胞的朊蛋白(PrPC)代谢和构象的改变是引发动物和人类可传播性海绵状脑病(transmissible spongiform encephalopathies,TSEs)的根本原因.将羊瘙痒病( scrapie)仓鼠适应株263K颅内接种仓鼠, 在接种后的第20、40、50、60、70、80天, 通过Western blot 动态检测仓鼠脑中PrP存在的形式.结果在接种后第40天, 在感染动物脑组织中即检测到 PrPSc分子,比临床症状出现的时间早(平均潜伏期为66.7±1.1天),且无糖基化形式的PrP分子所占百分比在接种后期增加明显.除了标准分子量大小(30kD~35kD)的 PrP分子外,在感染动物脑中存在着高分子量和低分子量形式的PrP分子 .定量分析显示,随着接种潜伏期的延长,不同形式PrP分子的含量也在增加,其中低分子量形式的PrP分子与临床症状的出现密切相关.蛋白去糖基化实验表明,在感染动物脑组织中,除了标准分子量大小的PrP蛋白外,还存在一条更小分子量的PrP条带,而正常动物脑组织仅存在标准大小的Pr P分子.低分子量形式的PrP分子具有与全长PrP分子相类似的糖基化模式.结果提示,scrapie 263K感染的仓鼠脑组织中存在不同分子形式的PrPSc,其PrP分子的代谢可能不同于正常动物.

  1. PrP-res Protein and Neuropathological Analyses of the Brain Tissues from Hamsters Infected with Scrapie 263K%羊瘙痒因子263K毒株感染金黄地鼠后鼠脑组织中检出PrP-res蛋白及其神经病理学研究

    Institute of Scientific and Technical Information of China (English)

    孙宪锋; 董小平; 张宝云; 侯星生; 胥爱源; 赵同兴; 洪涛

    2001-01-01

    Scrapie is a kind of transmissible spongiformencephalopathies(TSE)involving in sheep and goat. To study the characteristics of the infectious agent and the neuropathology, Scrapies agent 263K was inoculated into the brains of the hamsters. 81 to 110 days after inoculation, 89% animals(17/19)appeared typical symptoms of TSE. Neuropathological studies revealed that 59% infected hamsters showed spongiform degeneration and 17% showed amyloid plaques. By immunohistochemistry and proteinase K-digested Western blot, the proteinase-resistant PrP-res proteins were detected in the brain tissues from all the infected animals. The electrophoresis patterns and the evaluated molecular weights of the PrP-res proteins from 17 infected hamsters were all the same, presenting two bands between roughly 25 kD and 31 kD in Western blot assays. Moreover, imprints of fresh brain tissues on slides were tested for PrP-res proteins. It showed similar results as that of routinely used paraffin-embedded slides by immunohistochemistry assays, which implies that this technique might be an effective method to detect PrP-res in the brain biopsies of the patients with CJD. Successful infection of Scrapie agent 263K in hamsters confirmed that baby hamster is an ideal model for TSE agents, with shorter incubation period and higher morbidity. The detecting rate of PrP-res is clearly higher than that of the neuropathological changes in the brain tissues from the infected animals. The electrophoresis patterns of the newly formed PrP-res proteins depend on the inoculated TSE agents, but not the individual animals, suggesting that there might be various “strains" among TSE agents.%羊瘙痒病是累及山羊及绵羊的可传播海绵状脑病。为了观察羊瘙痒因子(Scrapie)的病原特征及病理组织改变特点,将羊瘙痒因子263K毒株颅内接种至金黄地鼠。经过81~110天的潜伏期,89%的动物发病(17/19只)。对发病地鼠的神经病理学检测发现,

  2. Days-lost to training and competition in relation to workload in 263 elite show-jumping horses in four European countries.

    Science.gov (United States)

    Egenvall, A; Tranquille, C A; Lönnell, A C; Bitschnau, C; Oomen, A; Hernlund, E; Montavon, S; Franko, M A; Murray, R C; Weishaupt, M A; Weeren, van R; Roepstorff, L

    2013-11-01

    Orthopaedic, or other, injuries in sports medicine can be quantified using the 'days-lost to training' concept. Both the training regimen and the surface used in training and racing can affect the health of racehorses. Our aim was to associate 'days-lost to training' in elite-level show-jumpers to horse characteristics, training and management strategies, and the time spent working on various training and competition surfaces. We designed a longitudinal study of professional riders in four European countries. Data were recorded using training diaries. Reasons for days-lost were classified into non-acute and acute orthopaedic, medical, hoof-related, and undefined. We produced descriptive statistics of training durations, relative to type of training, surfaces used, and days-lost. We created zero-inflated negative-binomial random-effects models using the overall days-lost as outcome. In the whole dataset, duration variables related to training surfaces were analysed as independent. The Swedish data only were also used to test whether duration variables were related to competition surfaces. Thirty-one riders with 263 horses provided data on 39,028 days at risk. Of these, 2357 (6.0%) were days-lost (55% and 22% of these were due to non-acute and acute orthopaedic injuries, respectively) in 126 horses. In the all-country model, controlling for season, a significant variable was country. Switzerland and the UK had lower incidence-rate ratios (IR) compared to Sweden (IRs 0.2 and 0.03, respectively). Horses with previous orthopaedic problems had almost a doubled IR (1.8) of days-lost due to orthopaedic injury, compared to baseline. If the horse had jumping training more than 1 min per day at risk the IRs were 6.9-7 (compared to less than this amount of time); this was, however, likely an effect of a small baseline. Variation in training was a protective factor with a dose-response relationship; the category with the highest variation had an IR of 0.1. In the Swedish model

  3. 羊瘙痒因子263K经多种途径感染仓鼠的脑外组织PrPSc分子和沉积特点研究%Comperative study of the characteristics of PrPSc molecules and deposits in spinal cords and peripheral tissues of hamsters infected with scrapie strain 263K by different pathways

    Institute of Scientific and Technical Information of China (English)

    张瑾; 陈岚; 肖新莉; 张宝云; 韩俊; 高建梅; 田海燕; 李冰玲; 姜慧英; 马贵平; 刘勇; 董小平

    2005-01-01

    目的比较研究实验仓鼠经不同途径感染羊瘙痒病(Scrapie)毒株263K的终末期病鼠脑外组织内PrPSc分子和沉积特点.方法以Scrapie 263K毒株经颅内、腹腔、心内、肌肉注射及灌胃等途径接种金黄地鼠,在终末期取脑、脊髓、脾、肾、舌、肌肉、小肠回盲部和胃组织,用HE染色观察病理变化,免疫组化法检测PrPSc的组织沉积特点,Western blot检测PrPSc分子特征.结果五种感染方式均可引起动物发病,在脑和脊髓组织中观察到典型的病理改变;PrPSc免疫组化检测显示外周途径感染动物脊髓白质内有大量沿纤维走行的PrPSc沉积,灰质前后角内围绕空泡点状或网状沉积,而颅内感染主要在中央管附近和后角出现大量的点状PrPSc沉积;脾脏、肾、小肠回盲部、胃组织中均观察到点状PrPSc的沉积;WesternBlot检测发现不同感染途径动物脊髓提取物均出现可抵抗蛋白酶消化的PrPSc条带,与脑提取物中PrPSc电泳性状完全一致;外周组织仅在脾脏检测到抵抗蛋白酶消化的PrPSc,但与正常对照比较,各种组织中PrP的总量明显增高,同时呈现与中枢神经组织不同的PrP电泳特征.结论在TSE感染发病过程中,多种组织细胞成分可能参与了TSE感染因子的向中枢神经系统传递过程,PrP蛋白在中枢神经组织和其他外周组织细胞中的翻译后修饰及代谢可能存在着不同的途径.

  4. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells.

    Science.gov (United States)

    Matsumoto, Masaru; Nakajima, Wataru; Seike, Masahiro; Gemma, Akihiko; Tanaka, Nobuyuki

    2016-04-29

    Cisplatin is a highly effective anticancer drug for treatment of various tumors including non-small-cell lung cancer (NSCLC), and is especially useful in cases nonresponsive to molecular-targeted drugs. Accumulating evidence has shown that cisplatin activates the p53-dependent apoptotic pathway, but it also induces apoptosis in p53-mutated cancer cells. Here we demonstrated that DNA-damage inducible proapoptotic BH3 (Bcl-2 homology region 3)-only Bcl-2 family members, Noxa, Puma, Bim and Bid, are not involved in cisplatin-induced apoptosis in human NSCLC cell lines. In contrast, the expression of proapoptotic multidomain Bcl-2-family members, Bak and Bax, was induced by cisplatin in p53-dependent and -independent manners, respectively. Moreover, in wild-type p53-expressing cells, cisplatin mainly used the Bak-dependent apoptotic pathway, but this apoptotic pathway shifted to the Bax-dependent pathway by loss-of-function of p53. Furthermore, both Bak- and Bax-induced apoptosis was enhanced by the antiapoptotic Bcl-2 family member, Bcl-XL knockdown, but not by Mcl-1 knockdown. From this result, we tested the effect of ABT-263 (Navitoclax), the specific inhibitor of Bcl-2 and Bcl-XL, but not Mcl-1, and found that ABT-263 synergistically enhanced cisplatin-induced apoptosis in NSCLC cells in the presence or absence of p53. These results indicate a novel regulatory system in cisplatin-induced NSCLC cell apoptosis, and a candidate efficient combination chemotherapy method against lung cancers.

  5. Development of Scrapie GSH 263K Pathological Prion Proteins Reference Material%金黄地鼠羊瘙痒病病理性朊蛋白标准物质的研制

    Institute of Scientific and Technical Information of China (English)

    刘全国; 马贵平; 李炎鑫; 史喜菊; 李冰玲

    2010-01-01

    选择25只羊痒病金黄地鼠标准毒株GSH 263K临床末期的脑组织,经一系列离心洗涤纯化和蛋白酶K 处理,获得高纯度的病理性朊蛋白.高纯度的病理性朊蛋白经80%甲酸灭活处理和真空离心干燥制备为待检标准物质,待检标准物质均匀性检验和稳定性检验其结果符合国家标准物质技术规范的要求.

  6. 浙江省263对男性HIV抗体阳性配偶间艾滋病传播的相关因素分析%Analysis of related factors for HIV transmission among 263 pairs of male spouses with positive HIV antibodies in Zhejiang province

    Institute of Scientific and Technical Information of China (English)

    陈琳; 潘晓红; 杨介者; 徐云; 王憓; 周欣; 蒋婷婷; 马瞧勤

    2016-01-01

    目的:分析浙江省男性HIV抗体阳性的配偶间HIV传播情况及其相关因素。方法采用横断面研究,于2013年1—7月,以浙江省所有地区新检测发现的男性HIV阳性的单阳家庭(单阳家庭)和男性先感染HIV的双阳家庭(双阳家庭)为研究对象,共纳入单阳家庭210对,双阳家庭53对。对其进行问卷调查,包括基本情况(仅男性)、HIV感染意识、HIV检测意识和检测行为、性关系权利、女性的安全套使用效能、性行为等。采用χ2检验或Fisher确切概率法分析单阳家庭和双阳家庭上述信息的差异,采用多因素二分类非条件logistic回归模型分析男性HIV抗体阳性配偶间HIV传播的相关因素。结果263对研究对象中,男性以30~50岁为主,占57.8%(152例),女性以初中及以下文化程度为主,占79.1%(208例);HIV感染者和艾滋病患者共占41.1%(217例)。单阳家庭中,疾病病程为HIV感染者、发生男男性行为和听说过艾滋病的男性分别占61.9%(130例)、38.3%(80例)和81.9%(172例),均高于双阳家庭[47.2%(25例)、7.5%(4例)和64.2%(34例)](χ2值为3.80、18.33和7.86,P值分别为0.051、0.001和0.005);单阳家庭和双阳家庭中,最近6个月感染过性病的女性占9.3%(19例)和18.9%(10例)(χ2=3.89,P=0.049)。与疾病进程为HIV感染者的男性相比,艾滋病患者的配偶感染HIV的OR(95%CI)值为2.93(1.05~8.21);与感染之前未听说过艾滋病的男性相比,听说过者的配偶感染HIV的OR(95%CI)值为0.13(0.04~0.41);与未发生男男性行为者相比,发生该行为者的配偶传播HIV的OR(95%CI)值为0.14(0.03~0.73);与最近6个月未感染过性病的女性相比,感染过的女性被配偶感染HIV的OR(95%CI)值为4.86(1.23~19.11)。结论浙江省男性HIV抗体阳性家庭中,配偶感染HIV的风险与男性疾病病

  7. Characterization, molecular modeling and antimicrobial activity of metal complexes of tridentate Schiff base derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol.

    Science.gov (United States)

    Adly, Omima M I

    2012-09-01

    Metal complexes of Ni(II), Co(II), Cd(II), VO(IV) and UO(2)(VI) as well as several Cu(II) salts, including Cl(-),NO(3)(-),AcO(-),ClO(4)(-) and SO(4)(-2) with a tridentate O(2)N donor Schiff base ligand (H(2)L), synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 2-aminophenol, were prepared and characterized on the basis of elemental analyses, spectral, magnetic, molar conductance and thermal gravimetric analysis. Square planar, tetrahedral and octahedral geometries have been assigned to the prepared complexes. Molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data, and the changes of bond lengths are linearly correlated with IR data. The antimicrobial activities of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus as Gram positive bacteria, Proteus vulgaris as Gram negative bacteria and Candida albicans as fungus strain, and the results are discussed.

  8. Spectral characterization, molecular modeling and antimicrobial studies on hydrazone metal complexes of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)dione and S-methyl dithiocarbazate.

    Science.gov (United States)

    Taha, Ali; Emara, Adel A A; Mashaly, Mahmoud M; Adly, Omima M I

    2014-09-15

    Metal complexes of copper(II), nickel(II), cobalt(II), oxovanadium(IV), chromium(III) and cadmium(II) with a new bridged ONS dibasic tridentate hydrazone (H2L) derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with S-methyl dithiocarbazate have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, spectral (infrared, electronic, mass, 1H NMR and ESR) studies as well as thermal gravimetric analysis (TGA). The synthesized complexes have dimeric structures with the general formula [ML(NO3)m(H2O)x]2·nH2O·zMeOH, L=dianion of the hydrazone, m=0-1, x=0-2, n=0-4 and z=0-1. The metal complexes exhibited square planar, tetrahedral and octahedral geometrical arrangements, the molar conductivity data indicates that all complexes are neutral. The Coats-Redfern equation was used to calculate the kinetic and thermodynamic parameters for the different thermal decomposition stages of some complexes. Structural parameters of the ligand and its metal complexes have been theoretically computed on the basis of semiempirical PM3 level and the results were correlated with their experimental data. Antibacterial activities of the free ligand and its metal complexes were screened against various organisms.

  9. 某市263名公安干警血尿酸血脂水平测定及脂肪肝患病情况分析

    Institute of Scientific and Technical Information of China (English)

    姚齐龙; 宿萍; 周琼仙; 肖理

    2004-01-01

    目的了解崇州市公安干警血尿酸、血脂水平及无症状脂肪肝患病情况.方法胆固醇(TC)测定采用CHOD-PAP法、甘油三脂(TG)测定GPO-PAP法、血尿酸(UA)测定URO-PAP法.脂肪肝以B超为诊断依据.结果263名公安干警体检中,高脂血症患病率为45.63%,尤以高甘油三脂血症为主占41.06%,高尿酸血症检出率为37.26%,以男性为主.B超检出无症状脂肪肝26例且均为男性,脂肪肝患病率为9.89%.TC、TG、UA及脂肪肝有随年龄而逐渐上升的趋势.结论在公安干警中应加强健康教育、积极进行体育锻炼、提倡平衡膳食,预防心血管疾病的发生.

  10. Characterization, molecular modeling and antimicrobial activity of metal complexes of tridentate Schiff base derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol

    Science.gov (United States)

    Adly, Omima M. I.

    Metal complexes of Ni(II), Co(II), Cd(II), VO(IV) and UO2(VI) as well as several Cu(II) salts, including Cl,NO3-,AcO,ClO4- and SO4-2 with a tridentate O2N donor Schiff base ligand (H2L), synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 2-aminophenol, were prepared and characterized on the basis of elemental analyses, spectral, magnetic, molar conductance and thermal gravimetric analysis. Square planar, tetrahedral and octahedral geometries have been assigned to the prepared complexes. Molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data, and the changes of bond lengths are linearly correlated with IR data. The antimicrobial activities of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus as Gram positive bacteria, Proteus vulgaris as Gram negative bacteria and Candida albicans as fungus strain, and the results are discussed.

  11. Analysis of Copy Number Variations in Patients with Autism Using Cytogenetic and MLPA Techniques: Report of 16p13.1p13.3 and 10q26.3 Duplications

    Science.gov (United States)

    Ghasemi Firouzabadi, Saghar; Vameghi, Roshanak; Kariminejad, Roxana; Darvish, Hossein; Banihashemi, Susan; Firouzkouhi Moghaddam, Mahboubeh; Jamali, Peyman; Farbod Mofidi Tehrani, Hassan; Dehghani, Hossein; Raeisoon, Mohammad Reza; Narooie-Nejad, Mehrnaz; Jamshidi, Javad; Tafakhori, Abbas; Sadabadi, Saeid; Behjati, Farkhondeh

    2016-01-01

    Autism is a common neuropsychiatric disorder affecting 1 in 68 children. Copy number variations (CNVs) are known to be major contributors of autism spectrum disorder (ASD). There are different whole genome or targeted techniques to identify CNVs in the patients including karyotyping, multiplex ligation-dependent probe amplification (MLPA) and array CGH. In this study, we used karyotyping and MLPA to detect CNVs in 50 Iranian patients with autism. GTG banding and 4 different MLPA kits (2 subtelomeric and 2 autism kits) were utilized. To elevate our detection rate, we selected the sporadic patients who had additional clinical features including intellectual disability, seizure, attention deficit hyperactivity disorder, and abnormal head circumference. Two out of 50 patients (4%) showed microscopic chromosome abnormalities and 5 out of 50 (10%) demonstrated copy number gains or losses using MLPA kits. Including one overlapping result between karyotype and MLPA techniques, our overall detection rate was 6 out of 50 (12%). Three out of 6 CNVs were de novo and three others were paternally inherited. Two of CNVs detected by karyotyping and MLPA tests were 16p13.1q13.3 and 10q26.3 duplications, respectively. For these two CNVs genotype and phenotype of the patients were compared with other studies. Although the pathogenicity of cytogenetic results was certain, most of MLPA results needed to be better refined using other more accurate techniques such as array CGH. Our findings suggest that it might be possible to obtain some useful information using MLPA technique but it cannot be used as a single diagnostic tool for the autism. PMID:28357200

  12. Synthesis, molecular modeling, thermal and spectral studies of metal complexes of hydrazone derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and thiosemicarbazide.

    Science.gov (United States)

    Adly, Omima M I

    2011-09-01

    Metal complexes with the general formula [ML(H2O)(CH3OH)x]·nH2O·(CH3OH)y(NO3)z [M=Cu(II), Ni(II), Co(II), VO(IV), Cr(III), Cd(II), Zn(II) or UO2(VI); x=0-2; y=0,1; z=0,1; n=0-2, 6 and L=hydrazone (H2L) derived from condensation of thiosemicarbazide with 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione. The synthesized ligand and its metal complexes have been characterized on the basis of elemental analyses, spectral and magnetic studies as well as thermal gravimetric analysis (TGA). The deprotonated ligand acts as a dibasic tridentate (ONS) via phenolate oxygen, azomethine (CN), and thiolate (C-S) groups. Copper(II) complex exhibits square planar geometry. Nickel(II), chromium(III) and dioxouranium(VI) complexes exhibit octahedral geometry. Cobalt(II), cadmium(II) and zinc(II) complexes showed tetrahedral geometry, whereas oxovanadium(IV) reveals square pyramidal geometry. Thermal analysis are investigated and showed either three or four thermal decomposition steps. Kinetic parameters (Ea, A, ΔH, ΔS and ΔG) of the thermal decomposition stages have been evaluated using Coats-Redfern equations. The molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data such as IR and TGA results.

  13. 12 CFR 263.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... judge's staff who has not engaged in an investigative or prosecutorial role in a proceeding and who may... Corporation (the FDIC), the Office of Thrift Supervision (the OTS), and the National Credit...

  14. 40 CFR 263.10 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Scope. (d) A transporter of hazardous waste subject to the Federal manifesting requirements of 40 CFR... hazardous waste within the United States if the transportation requires a manifest under 40 CFR part 262... water, a transporter who meets all applicable requirements of 49 CFR parts 171 through 179 and...

  15. BDML Metadata: 263 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available CC BY-NC-SA 0.180 eb78ea72-e7d0-45f6-8d94-f3c87dbbc822 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http:/...dpml/Ce_KK_P002.pdpml0.06.xml http://ssbd.qbic.riken.jp/search/eb78ea72-e7d0-45f6-8d94-f3c87dbbc822/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-212 ...

  16. 7 CFR 1822.263 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... PRIMARILY FOR REAL ESTATE PURPOSES RURAL HOUSING LOANS AND GRANTS Rural Housing Site Loan Policies... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... agency of a State or local government. (c) Rural area is open country or rural places as defined in 7...

  17. 33 CFR 263.13 - Program scope.

    Science.gov (United States)

    2010-07-01

    ... accompanied by policy interpretation in subparts B, C and D of this part. (a) Small Flood Control Project Authority. Section 205, Flood Control Act of 1948, as amended (33 U.S.C 701s). (b) Authority for snagging and clearing for flood control. Section 208, Flood Control Act of 1954, as amended (33 U.S.C....

  18. 29 CFR 1910.263 - Bakery equipment.

    Science.gov (United States)

    2010-07-01

    ...) Troughs. Troughs shall be mounted on antifriction bearing casters thus making it possible for the operator... wrappers—(1) Slicers. (i)-(ii) (iii) The cover over the knife head of reciprocating-blade slicers shall be.... (iv) On slicers with endless band knives, each motor shall be equipped with a magnet brake...

  19. Reference: 263 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available idopsis leaves GLB1 expression and PII protein levels were not significantly affected by either the day/nigh...bolism. Physiological characterisation of Arabidopsis mutants affected in the expression of the putative reg

  20. 26 CFR 1.263A-0 - Outline of regulations under section 263A.

    Science.gov (United States)

    2010-04-01

    ...) Engineering and design services. (F) Safety engineering services. (v) Accounting method change. (h) Simplified... equipment. (S) Quality control. (T) Bidding costs. (U) Licensing and franchise costs. (V) Interest....

  1. Detection of PrP(Sc) in 263K GSH Hamster Lymphnodes at Preclinical Stage of Scrapie%在前临床期检测金仓鼠羊痒病淋巴结中病理型朊蛋白PrP(Sc)

    Institute of Scientific and Technical Information of China (English)

    刘全国; 马贵平; 李炎鑫; 史喜菊; 李冰玲; 司培培

    2012-01-01

    Twelve female five-week old GSH hamsters were injected i.p. with a 10% homogenat(e50 μL)of brain from 263K Scrapie. Early at the preclinical stage,the infected hamsters were sacrificed individually by 2,4,6,8,10,12,and 20 weeks after scrapie agent inoculation.Brain,lymph nodes,spleen,kidney,liver,heart and muscle were collected from each animal,then PrPSc was detected by inmmuno-western blot.The results demonstrated that after the improvement of extraction technology,early at the preclinical stage PrPSc was detected in spleen and lymph nodes,but were not detected in kidney,liver,heart and muscle tissues.%12只雌性5周龄金仓鼠腹腔注射50μL羊痒病(SCRAPIE)263K株10%的脑组织匀浆。在临床前期,感染后第2、4、6、8、10、12周和临床末期第20周,金仓鼠被分别处死,取大脑、淋巴组织、脾脏、肾脏、肝脏、心脏和肌肉等组织,进行蛋白质免疫印迹杂交实验检测朊病毒病理型朊蛋白PrPSc。研究结果显示在临床前期,通过改进后的纯化技术,我们能够检测出淋巴组织和脾脏组织中的PrPSc,但是在肾脏、肝脏、心脏和肌肉等组织中仍然没有检测到PrPSc。

  2. Establishment of a prion disease PrPSc panel from the brain tissues of experimental hamsters infected with scrapie agent 263K%朊病毒病实验动物脑组织PrPSc样本库的建立

    Institute of Scientific and Technical Information of China (English)

    张宝云; 田婵; 韩俊; 高晨; 石琦; 姜慧英; 周伟; 董小平

    2008-01-01

    Objective To establish a prion disease PrPSc panel from the brain tissues of experimental hamsters and to address the stability of the panel conserved under the specific condition, for evaluating the diagnostic techniques of human and animal's prion diseases. Methods 30 brain tissues of hamsters infected with scrapie strain 263K intracerebrally and 30 ones of normal hamsters were enrolled in this panel. Each brain sample was prepared to 10%, 1% and 0.5% homogenates and aliquoted into stocks. The presences of PrPSc in each brain sample were evaluated with PrP-specific Western Blots and partially with immunohistochemistry, and the stabihty of PrPSc signals in each sample were repeatedly assessed half a year later and 3 years later. Results PrPSc signals were detected in all stocks of 10% brain homogenates from infected hamsters, 26 out of 30 stocks of 1% homogenates and 19 out of 30 stocks of 0.5 % homogenates. The assessments of PrPSc signals in all samples half-year and three years later demonstrated almost unchanged. All homogenates of brain tissues of normal hamsters were PrPSc negative. Conclusion A prion disease PrPSc panel of the brain tissues, which includes 90 PrPSc positive stocks and PrPSc negative ones, was successfully estabhshed, with a reliable stability of PrPSc signals.%目的 建立朊病毒病实验动物脑组织检测样本库,检测其在特定保存条件下的稳定性,以用于动物和人朊病毒病诊断技术的评估和考核.方法 选用30只经颅内注射感染羊瘙痒因子263K的仓鼠和30只正常仓鼠,每只分别制备10%、1%和0.5%3种浓度的脑组织匀浆,分装冷冻保存.以Western Blot方法 确定脑组织匀浆中PrPSc的存在情况,并分别在建库半年和3年检测PrPSc的稳定性.结果 30只感染仓鼠10%脑组织匀浆全部可检出PrPSc,1%脑组织匀浆有26份为PrPSc阳性,0.5%脑组织匀浆有19份为PrPSc阳性.半年及3年后复检,PrPSc阳性检出率基本不变.所有正常仓鼠脑匀

  3. Dicty_cDB: SHB263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 DT364098 |DT364098.1 JGI_ANNN9278.rev ANNN Pimephales promelas Whole (L) Pimephales promelas cDNA clone A...NNN9278 3', mRNA sequence. 48 0.25 1 DT347978 |DT347978.1 JGI_CAAX10802.fwd CAAX Pimephales promelas testis ...7-8 month adults, males and females pooled (L) Pimephales promelas cDNA clone CAAX10802 5', mRNA sequence. 4...8 0.25 1 DT309975 |DT309975.1 JGI_CAAX1517.fwd CAAX Pimephales promelas testis 7-...8 month adults, males and females pooled (L) Pimephales promelas cDNA clone CAAX1517 5', mRNA sequence. 48 0

  4. 26 CFR 1.263A-11 - Accumulated production expenditures.

    Science.gov (United States)

    2010-04-01

    ... adjusted bases of any assets described in paragraph (d) of this section that are used to produce the unit... extent they would otherwise be taken into account under the taxpayer's method of accounting (e.g., after.... For purposes of determining accumulated production expenditures on any measurement date during...

  5. Dicty_cDB: SSK263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 10 tomato flower buds, anthesis, Cornell University Lycopersicon esculentum cDNA clone cTOD1C15, mRNA sequen...ce. 92 2e-15 2 AI778006 |AI778006.1 EST258885 tomato susceptible, Cornell Lycoper...4 tomato root during/after fruit set, Cornell University Lycopersicon esculentum ...flower buds, anthesis, Cornell University Lycopersicon esculentum cDNA clone cTOD11C15 5' end, mRNA sequence... pennellii cDNA clone cLPP8K18 5' sequence, mRNA sequence. 92 3e-15 2 BG642411 |BG642411.1 EST355887 tomato

  6. Dicty_cDB: VSC263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available . 278 1e-73 BT078708_1( BT078708 |pid:none) Lepeophtheirus salmonis Pacific fo... 274 2e-72 FJ376460_1( FJ376460 |pid:none) Spea hamm...ondii ribosomal protein L... 273 2e-72 ( P41116 ) RecName: Full=60S ribosomal prote

  7. 12 CFR 263.305 - Enforcement of orders.

    Science.gov (United States)

    2010-01-01

    ... section 8(i)(1) of the FDI Act. (b) Failure to comply with order. Pursuant to section 8(i)(2)(A) of the FDI Act, the Board may assess a civil money penalty against any State member bank that violates...

  8. 12 CFR 263.50 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... under section 38 of the FDI Act (12 U.S.C. 1831o); (12) Reclassification of a member bank on grounds of unsafe or unsound condition under section 38(g)(1) of the FDI Act (12 U.S.C. 1831o(g)(1)); (13) Reclassification of a member bank on grounds of unsafe and unsound practice under section 38(g)(1) of the FDI...

  9. 26 CFR 1.263A-10 - Unit of property.

    Science.gov (United States)

    2010-04-01

    ... purposes, personal use purposes, or specified future development as a separate unit of real property). (2... any time which would not qualify as a cessation of production activities under the suspension period.... B, an individual, is in the trade or business of constructing custom-built houses for sale. B owns...

  10. Dicty_cDB: CHK263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available DNA sequence. 50 0.039 1 BF050079 |BF050079.1 As_tgz_22C04_SKPL Ascaris suum adult male testis germinal...9 1 BM278751 |BM278751.1 As_tgz_66H01_SKPL Ascaris suum adult male testis germinal zone from Alan Scott Asca

  11. 12 CFR 263.84 - Enforcement of directive.

    Science.gov (United States)

    2010-01-01

    ... or adhere to a capital adequacy plan as required by such directive, the Board may seek enforcement of the directive, including the capital adequacy plan, in the appropriate United State district court... any subsidiary thereof in adhering to any directive or capital adequacy plan required by the...

  12. 12 CFR 263.402 - Removal, suspension, or debarment.

    Science.gov (United States)

    2010-01-01

    ... accountant from performing audit services for banking organizations that are subject to section 36 of the..., immediately suspend such accountant or firm from performing audit services for banking organizations, if the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Removal, suspension, or debarment....

  13. 12 CFR 263.403 - Automatic removal, suspension, and debarment.

    Science.gov (United States)

    2010-01-01

    ... independent public accountant or accounting firm may not perform audit services for banking organizations if... permission to such accountant or firm to perform audit services for banking organizations. The request shall... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Automatic removal, suspension, and...

  14. 26 CFR 1.263(a)-0 - Table of contents.

    Science.gov (United States)

    2010-04-01

    ... services. (iv) Creation of computer software. (v) Creation of package design. (4) Coordination with other... general. (2) Readily available software. (3) Intangibles acquired from an employee. (4) Examples. (d... pooling. (1) In general. (2) Method of accounting. (3) Adopting or changing to a pooling method....

  15. 26 CFR 1.263A-12 - Production period.

    Science.gov (United States)

    2010-04-01

    ... production activities—(1) In general. The term physical production activities includes any physical activity...) Incidental repairs. Physical activities of an incidental nature that may be treated as repairs under § 1.162... starting with the first measurement period that begins after the first day in which production ceases....

  16. 43 CFR 26.3 - Program purpose and objectives.

    Science.gov (United States)

    2010-10-01

    ...' representatives, the following characteristics: (1) A properly balanced and integrated environmental work-learning... interaction and group learning (e.g., evening cookouts, overnight or weekend camping). (4) An enrollment of sufficient size (not less than 10 enrollees) that will permit social interaction and group learning....

  17. 12 CFR 263.93 - Eligibility to practice.

    Science.gov (United States)

    2010-01-01

    ... debarment pursuant to this subpart may practice before the Board. (b) Accountants. Any accountant who is qualified to practice as a certified public accountant or public accountant and is not currently...

  18. Dicty_cDB: VHF263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 16986 ) Dictyostelium discoideum chromosome 2 map 2234041... 42 0.011 14 ( DD391852 ) Method and nucleic acids for the improve...d treatme... 54 0.013 1 ( DD391578 ) Method and nucleic acids for the improved treatme...

  19. Dicty_cDB: AFB263 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available .. 138 9e-32 AY336797_1( AY336797 |pid:none) Rhipicephalus haemaphysaloides hae... 137 1e-31 AY207373_1( AY207373 |pid:none) Tenebrio... molitor cathepsin L-like ... 135 4e-31 AY332271_1( AY332271 |pid:none) Tenebrio mo

  20. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

    NARCIS (Netherlands)

    Chang, Jianhui; Wang, Yingying; Shao, Lijian; Laberge, Remi-Martin; Demaria, Marco; Campisi, Judith; Janakiraman, Krishnamurthy; Sharpless, Norman E; Ding, Sheng; Feng, Wei; Luo, Yi; Wang, Xiaoyan; Aykin-Burns, Nukhet; Krager, Kimberly; Ponnappan, Usha; Hauer-Jensen, Martin; Meng, Aimin; Zhou, Daohong

    2015-01-01

    Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders, suggesting that SCs play a causative role in certain age-related pathologies. T

  1. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families

    DEFF Research Database (Denmark)

    Kashevarova, Anna A; Nazarenko, Lyudmila P; Schultz-Pedersen, Soren

    2014-01-01

    . The CHL1 and CNTN4 genes, although adjacent to the CNTN6 gene, were not affected in either of these patients. CONCLUSIONS: The protein encoded by CNTN6 is a member of the immunoglobulin superfamily and functions as a cell adhesion molecule that is involved in the formation of axon connections...

  2. 34 CFR 263.5 - What priority is given to certain projects and applicants?

    Science.gov (United States)

    2010-07-01

    ... significant Indian student populations. Note to paragraph (c)(1): In working with various institutions of... eligible applicants that includes a tribal college or university and that designates that tribal college or... teacher. These students would be eligible to participate as long as their training meets the...

  3. 45 CFR 263.0 - What definitions apply to this part?

    Science.gov (United States)

    2010-10-01

    ... projects; (v) Fraud and abuse units; (vi) Procurement activities; (vii) Public relations; (viii) Services related to accounting, litigation, audits, management of property, payroll, and personnel; (ix) Costs...

  4. 12 CFR 263.303 - Filing of safety and soundness compliance plan.

    Science.gov (United States)

    2010-01-01

    ... 38 of the FDI Act (12 U.S.C. 1831o), a cease-and-desist order entered into pursuant to section 8 of the FDI Act, a formal or informal agreement, or a response to a report of examination or report of... capitalized for purposes of section 38 of the FDI Act. For purposes of calculating an increase in...

  5. 34 CFR 263.6 - How does the Secretary evaluate applications for the Professional Development program?

    Science.gov (United States)

    2010-07-01

    ... effective strategies for teaching and student achievement; (2) The likelihood that the proposed project will... to improvements in the achievement of students as measured against rigorous academic standards; and... research and effective practices on how to improve teaching and learning to support student proficiency...

  6. E331 Behavior TP HF RW O3 SHC2.63

    Data.gov (United States)

    U.S. Environmental Protection Agency — Human and animal studies indicate that maternal obesity can negatively impact aspects of metabolism and neurodevelopment in the offspring. Not known, however, is...

  7. 26 CFR 1.263A-3 - Rules relating to property acquired for resale.

    Science.gov (United States)

    2010-04-01

    ... indicate activities outside the area of purchasing (e.g., a marketing representative), such activities must...) Simplified resale method—(1) Introduction. This paragraph (d) provides a simplified method for...

  8. 26 CFR 1.263A-8 - Requirement to capitalize interest.

    Science.gov (United States)

    2010-04-01

    ...) Timber and evergreen trees that are more than 6 years old when severed from the roots, or (ii) Property... include growing crops and plants, mines, wells, and other natural deposits. Growing crops and...

  9. 34 CFR 263.3 - What definitions apply to the Professional Development program?

    Science.gov (United States)

    2010-07-01

    ... near the institution; dependent allowance; and instructional supplies. Full course load means the... minimum, these activities: (1) Mentoring, coaching, and consultation services for the participant...

  10. 26 CFR 1.263A-13 - Oil and gas activities.

    Science.gov (United States)

    2010-04-01

    ... activities (such as building an access road, leveling a site for a drilling rig, or excavating a mud pit) are... the taxpayer cannot establish, at the beginning of the production period of the first well drilled on... of the first well drilled on the property, the taxpayer may either apply the rules of paragraph...

  11. Yeast Interacting Proteins Database: YLR263W, YDR510W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available W SMT3 Ubiquitin-like protein of the SUMO family, conjugated to lysine residues o...MT3 Prey description Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target prot

  12. 26 CFR 1.263A-1 - Uniform capitalization of costs.

    Science.gov (United States)

    2010-04-01

    ... significant factor in making this determination is the relationship between the acquisition or direct... and eating facilities, membership dues, etc. Employee benefit expenses do not, however, include direct... and facilities are temporarily idle when a taxpayer takes them out of service for a finite...

  13. 26 CFR 1.263(a)-4 - Amounts paid to acquire or create intangibles.

    Science.gov (United States)

    2010-04-01

    ... this section; (iii) An amount paid to create or enhance a separate and distinct intangible asset within... on or after the date of publication of the guidance. (3) Separate and distinct intangible asset—(i) Definition. The term separate and distinct intangible asset means a property interest of ascertainable...

  14. 12 CFR 263.85 - Establishment of increased capital level for specific institutions.

    Science.gov (United States)

    2010-01-01

    ... establish a capital level higher than the minimum specified in the Board's Capital Adequacy Guidelines for a... capital levels above those in the Board's Capital Adequacy Guidelines may be necessary and appropriate for... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Establishment of increased capital level...

  15. 33 CFR Appendix B to Part 263 - Application of Multiobjective Planning Framework to Continuing Authorities Program

    Science.gov (United States)

    2010-07-01

    ... study, while more intense efforts at data collection and definition of the problems and associated needs... mind the requirements of the National Environmental Policy Act of 1969 (NEPA) and Section 122,...

  16. Yeast Interacting Proteins Database: YNL263C, YGR172C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ows with this prey as prey (3) Rows with this prey as bait Rows with this prey as bait (0) Literature on bait (YPD) 6 Literature... on prey (YPD) 6 Literature shared by bait and prey 3 Literature

  17. A PREDICTION BASED ALL-ZERO BLOCK DETECTION METHOD FOR H.263

    Institute of Scientific and Technical Information of China (English)

    Tian Dong; Yao Zhiheng; Shen Lansun

    2002-01-01

    In this letter, a novel method based on Temporal and Spatial Prediction (TSP) to detect all-zero DCT coefficients based on temporal and spatial prediction between neighboring blocks is proposed. The presented algorithm uses the knowledge of all-zero block distribution in the previous frame combined with the Sum of Absolute Difference (SAD) of the corresponding macroblock as a criterion. The algorithm almost needs no additional computation, and it shows an excellent overall detection performance in simulations.

  18. A PREDICTION BASED ALL—ZERO BLOCK DETECTION METHOD FOR H.263

    Institute of Scientific and Technical Information of China (English)

    TianDong; YaoZhiheng; 等

    2002-01-01

    In this letter,a novel method based on Temporal and Spatial Prediction(TSP)to detect all-zero DCT coefficients based on temporal and spatial prediction between neighboring blocks is proposed.The presented algorithm uses the knowledge of all-zero block distribution in the previous frame combined with the Sum of Absolute Difference(SAD)of the corresponding macroblock as a criterion .The algorithm almost needs no additional computation ,and it shows an excellent overall detection performance in simulations.

  19. 26 CFR 1.263A-9 - The avoided cost method.

    Science.gov (United States)

    2010-04-01

    ... provision described in § 1.163-8T(m)(7)(ii); (ii) Debt, such as accounts payable and other accrued items..., debt specified in paragraph (a)(4)(ii) of this section (e.g., accounts payable) may be included in... accounts payable traced to unit A $100,000 Noninterest-bearing accounts payable that are not traced to...

  20. SU-E-J-263: Repeatability of SUV and Texture Parameters in Serial PET Studies

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, J; Humm, J; Nehmeh, S; Schoder, H [Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

    2015-06-15

    Purpose: Standardized uptake values (SUV) are standard quantitative PET measures of FDG tumor uptake used,and are used as a tool to monitor response to therapy. Textural analysis is emerging as a new tool for assessing intratumoral heterogeneity which may allow better tissue characterization and improved prediction of response and survival rate.Understanding what variations may be expected in these parameters is key in order to make decisions based on how the change throughout the course of treatment. The aim of this study was to assess repeatability in SUV measures and texture parameters,and establish criteria that differentiate changes associated with treatment rather than statistical variability. Methods: Eighty patients,167 random lesions total,were scanned in a GE Discovery STE PET/CT Scanner. One field-of-view was chosen centered on the largest lesion observed in a clinical whole-body FDG PET.Immediately following,a gated 9 min scan was acquired in list mode,without changing the patient’s position between any scans. Data was replayed into 3 time bins,3 min each,in order to insure equivalent noise characteristics in each replicate.Data was reconstructed into 128×128×47 square matrices.One VOI was drawn over each lesion for each patient and used to segment all 3 replicates. The mean.max and peak SUV were calculated for each VOI and replicate. First-order textural features were also calculated (skewness and kurtosis). Repeatability was calculated as the average standard deviation over the mean for the 3 repeated measurements for each lesion. Results: The average percent error in the SUV max,peak and mean were 3.4%(0– 12.9%),1.9% (0–7.5%),2.8% (0–12.2%),respectively.For skewness and kurtosis they were 10.9% and 17.8%. Conclusion: We have shown that there is a large variation in %error in SUV measures across patients. SUVpeak is the least variable and kurtosis and skewness parameters are less reliable thatn SUVs.Higher order textures are be.

  1. 34 CFR 263.21 - What priority is given to certain projects and applicants?

    Science.gov (United States)

    2010-07-01

    ... Children program. A consortium of eligible entities that meets the requirements of 34 CFR 75.127 through 75..., including family-based preschool programs, emphasizing school readiness and parental skills. (3) College... postsecondary education. (Authority: 20 U.S.C. 7441 and 7473)...

  2. 26 CFR 1.263(e)-1 - Expenditures in connection with certain railroad rolling stock.

    Science.gov (United States)

    2010-04-01

    ... may be aggregated without regard to the unit in the project with respect to which each expenditure is connected, and an amount equal to the aggregate expenditures for the project divided by the number of units... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Expenditures in connection with certain...

  3. 26 CFR 1.263(b)-1 - Expenditures for advertising or promotion of good will.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Expenditures for advertising or promotion of... advertising or promotion of good will. See § 1.162-14 for the rules applicable to a corporation which has elected to capitalize expenditures for advertising or the promotion of good will under the provisions...

  4. 26 CFR 1.263A-4 - Rules for property produced in a farming business.

    Science.gov (United States)

    2010-04-01

    ... make a reasonable contribution to an allocable share of farm expenses. (D) Examples. The following... incurs expenses related to the fig operation of: $50x to harvest the figs and transport them to market... grows apple trees that have a preproductive period greater than 2 years. In addition, Farmer A grows...

  5. NUCLEAR CHEMISTRY: Element 107 Leaves the Table Unturned.

    Science.gov (United States)

    Service, R F

    2000-08-25

    This week, an international team of chemists reported on the first successful analysis of the chemical properties of bohrium, element 107. The results matched predictions, postponing scientists' hopes of seeing interesting deviations from theory among ultraheavy elements.

  6. 用N-263从废钒催化剂中回收钒的工艺研究%Study on Recovery Technology of Vanadium Oxide from Waste Catalyst by Using N-263

    Institute of Scientific and Technical Information of China (English)

    郝喜才; 胡斌杰

    2014-01-01

    研究了将废钒催化剂经过氧化焙烧-水浸-渣碱浸-萃取-沉钒等环节制备V2O5的新工艺.探讨了工艺参数对助剂配方、氧化焙烧、浸钒与萃取影响的规律性,为推广工业生产提供适宜的工艺条件.在此工艺条件下,可以制备出质量达到国标GB3283-87冶金99级标准的V2O5产品,钒回收率达91.2%,具有较好的环境效益、经济效益和社会效益,值得推广.

  7. Comparison of environmental risk factors for esophageal atresia, anorectal malformations, and the combined phenotype in 263 German families.

    Science.gov (United States)

    Zwink, N; Choinitzki, V; Baudisch, F; Hölscher, A; Boemers, T M; Turial, S; Kurz, R; Heydweiller, A; Keppler, K; Müller, A; Bagci, S; Pauly, M; Brokmeier, U; Leutner, A; Degenhardt, P; Schmiedeke, E; Märzheuser, S; Grasshoff-Derr, S; Holland-Cunz, S; Palta, M; Schäfer, M; Ure, B M; Lacher, M; Nöthen, M M; Schumacher, J; Jenetzky, E; Reutter, H

    2016-11-01

    Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) and anorectal malformations (ARM) represent the severe ends of the fore- and hindgut malformation spectra. Previous research suggests that environmental factors are implicated in their etiology. These risk factors might indicate the influence of specific etiological mechanisms on distinct developmental processes (e.g. fore- vs. hindgut malformation). The present study compared environmental factors in patients with isolated EA/TEF, isolated ARM, and the combined phenotype during the periconceptional period and the first trimester of pregnancy in order to investigate the hypothesis that fore- and hindgut malformations involve differing environmental factors. Patients with isolated EA/TEF (n = 98), isolated ARM (n = 123), and the combined phenotype (n = 42) were included. Families were recruited within the context of two German multicenter studies of the genetic and environmental causes of EA/TEF (great consortium) and ARM (CURE-Net). Exposures of interest were ascertained using an epidemiological questionnaire. Chi-square, Fisher's exact, and Mann-Whitney U-tests were used to assess differences between the three phenotypes. Newborns with isolated EA/TEF and the combined phenotype had significantly lower birth weights than newborns with isolated ARM (P = 0.001 and P expectation, and warrants further analysis in large prospective epidemiological studies.

  8. Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263 K scrapie agent.

    Science.gov (United States)

    Choi, S I; Ju, W K; Choi, E K; Kim, J; Lea, H Z; Carp, R I; Wisniewski, H M; Kim, Y S

    1998-09-01

    Scrapie, one of the prion diseases, is a transmissible neurodegenerative disease of sheep and other animals. Clinical symptoms of prion diseases are characterized by a long latent period, followed by progressive ataxia, tremor, and death. To study the induction of neurodegeneration during scrapie infection, we have analyzed the activities of various antioxidant enzymes and mitochondrial enzymes in cerebral cortex, brain stem, and cerebellum of scrapie-infected hamsters. The activity of mitochondrial Mn-superoxide dismutase (SOD) was decreased, while the activities of cytosolic Cu/Zn-SOD and catalase were not altered in infected brains. The activities of glutathione peroxidase and glutathione reductase were increased in scrapie-infected hamsters. The decreased activity of Mn-SOD might result in increasing oxidative stress in the mitochondria of infected brain; this concept is supported by our findings of a high level of lipid peroxidation, and low levels of ATPase and cytochrome c oxidase activity in the infected cerebral mitochondria. In addition, structural abnormalities of mitochondria have been observed in the neurons of hippocampus and cerebral cortex of infected brain. These results suggest that mitochondrial dysfunction caused by oxidative stress gives rise to neurodegeneration in prion disease.

  9. AFSC/RACE/EcoFOCI: 2011 Gulf of Alaska IERP Cruise TN263/1TT11

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A total of 105 stations were occupied. There were two sample grids (southeast Alaska and Yakutat Bay) and two transects in the vicinity of Kayak Island. At each...

  10. Discurso y no ser en Platón (Sofista 260a-263d)

    OpenAIRE

    Marcos de Pinotti, Graciela Elena

    1997-01-01

    El problema de la falsedad enfrentó a Platón con los sofistas de su época e indirectamente con el "padre Parménides", de cuya ontología derivaba la tesis sofística de la imposibilidad de lo falso. Si no hay no ser y es imposible pensarlo o decirlo -argüía el sofista apelando, hábilmente, a la autoridad del fundador del eleatismo- es imposible pensar o decir algo falso, ya que la falsedad no es otra cosa que pensar o decir "lo que no es". A combatir este argumento se consagraron los esfuerzos ...

  11. 45 CFR 263.2 - What kinds of State expenditures count toward meeting a State's basic MOE expenditure requirement?

    Science.gov (United States)

    2010-10-01

    ... AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES EXPENDITURES OF STATE AND FEDERAL TANF FUNDS... separate State programs may count if they are made for the following types of benefits or services: (1...) of the Act including: (i) Nonmedical treatment services for alcohol and drug abuse and some...

  12. 77 FR 263 - Certain Cut-To-Length Carbon-Quality Steel Plate From Italy and Japan: Revocation of Antidumping...

    Science.gov (United States)

    2012-01-04

    ... physical description, and in which the chemistry quantities do not equal or exceed any one of the levels...''), respectively. See Initiation of Five-Year (``Sunset'') Review, 75 FR 67082 (November 1, 2010). As a result of... closed box pass, of a width exceeding 150 mm but not exceeding 1250 mm, and of a nominal or...

  13. A Report of Archaeological Testing at Site 3CT263 Within the Proposed Edmondson Wastewater Pond, Crittendon County, Arkansas

    Science.gov (United States)

    1990-09-01

    and Mixing 15 Vernacular Architecture and Disappearing Structures 15 Site Formation and Preservation Factors 16 Archival and Field Methods 16...period format Paleoindian Period The Paleoindian period (ca. 11,500-9800 B.P I represents the earliest human occupation in the southeastern United...Governor of Louisiana, as a agent to the Chickasaw. In 1797 he moved from Ft. San Fernando de las Barrancas (present day Memphis) to a new fort on the

  14. Features of structures formation on the basis of chitosan derivatives by a prototype of 263 nm laser stereolithograph

    Science.gov (United States)

    Dudova, D. S.; Bardakova, K. N.; Akopova, T. A.; Timashev, P. S.; Minaev, N. V.

    2016-08-01

    We have developed technology of polysaccharides based matrices formation by laser stereolithography (SLA) method using UV range laser radiation. Experimental data on a laser parameters selection of single-layer structures polymerization for compositions based on unsaturated chitosan derivatives with different degree of substitution and with the addition of polyethylene glycol diacrylate is shown.

  15. Days-lost to training and competition in relation to workload in 263 elite show-jumping horses in four European countries

    NARCIS (Netherlands)

    Egenvall, A; Tranquille, C A; Lönnell, A C; Bitschnau, C; Oomen, A; Hernlund, E; Montavon, S; Franko, M A; Murray, R C; Weishaupt, M A; Weeren, van R; Roepstorff, L; van Weeren, René

    2013-01-01

    Orthopaedic, or other, injuries in sports medicine can be quantified using the 'days-lost to training' concept. Both the training regimen and the surface used in training and racing can affect the health of racehorses. Our aim was to associate 'days-lost to training' in elite-level show-jumpers to h

  16. Evaluation of nitrogenous media components by Plackett-Burman statistical design for beta-d-fructofuranosidase production by Saccharomyces sp. strain GVT263.

    Science.gov (United States)

    Venkateshwar, M; Chaitanya, K; Altaf, M D; Hameeda, B; Ghopal Reddy, M

    2009-04-01

    beta-d-Fructofuranosidase (FFase), an important enzyme of the confectionery and fructose syrup industry, is produced by several microorganisms. However, yeasts are the most used source because of their high sucrose fermentation capacity. In this work, production of FFase was carried out in submerged fermentation using a high enzyme-producing yeast strain. Plackett-Burman statistical experimental design was applied to evaluate the fermentation medium components. The effects of 10 nitrogen sources were studied in a 16-run experimental design. Beef extract, yeast extract, N-Z-amine, tryptone, meat extract, and ammonium acetate were found to have significant effects on enzyme production. Among these, yeast extract, N-Z-amine, and ammonium acetate were the most significant. A maximum FFase activity of 299.4 U/mL was obtained after a 24 h fermentation period.

  17. Novel small molecule inhibitors of MDM2/4-p53 interaction, YH264 and its ethyl ester YH263: Preclinical evaluation

    NARCIS (Netherlands)

    Christner, Susan M.; Clausen, Dana M.; Beumer, Jan H.; Parise, Robert A.; Huang, Yi; Dömling, Alexander S.; Eiseman, Julie L.

    2012-01-01

    Introduction: In p53+/+ cells, expression of MDM2/4 leads to turnover of p53 and inhibition of downstream gene transcription decreasing cell cycle arrest or apoptosis. Prevention of MDM2/4-p53 interaction is a promising therapeutic strategy. Two in-house developed small molecule inhibitors of MDM2/4

  18. Investigations on ideal mode of cell disruption in extremely halophilic Actinopolyspora halophila (MTCC 263 for efficient release of glycine betaine and trehalose

    Directory of Open Access Journals (Sweden)

    Jayaranjan R. Kar

    2015-03-01

    Full Text Available Actinopolyspora halophila produces glycine betaine and trehalose intracellularly in considerable quantities. These biomolecules are commercially important as they have applications in food, pharmaceuticals, and agricultural sector. Development of an efficient cell disruption technique is an important step for the release of these biomolecules. In this study, various cell disruption methods such as chemical, enzymatic, physico-mechanical and physical methods were evaluated. Cell disruption by osmotic shock was found to be the best suited method for A. halophila which also has a potential to be industrially scaled up. Cell bursting pressure that is generated during osmotic shock in A. halophila was computed using Morse equation and was found to be π = 238.37 ± 29.54 atm or 2.35 ± 0.29 kPa. In addition, it was found that osmotic shock followed a first order release rate kinetics in A. halophila. The findings can be used for commercially important biomolecules from other halophilic and/or halotolerant microbes.

  19. District of Columbia Charter Schools: Criteria for Awarding School Buildings to Charter Schools Needs Additional Transparency. Report to Congressional Committees. GAO-11-263

    Science.gov (United States)

    Scott, George A.

    2011-01-01

    Almost 40 percent of all public school students in the District of Columbia (D.C. or District) were enrolled in charter schools in the 2010-11 school year. The D.C. School Reform Act established the Public Charter School Board (PCSB) for the purpose of authorizing and overseeing charter schools. Congress required GAO (US Government Accountability…

  20. 26 CFR 1.263(a)-5 - Amounts paid or incurred to facilitate an acquisition of a trade or business, a change in the...

    Science.gov (United States)

    2010-04-01

    ... activities occur. (7) Registrar and transfer agent fees for the maintenance of capital stock records. An... section 162 or 212. Instead, the amount required to be capitalized generally reduces the total premium... issuance of the stock and whether or not the registration is productive of equity capital). Example...

  1. Microduplications of 3p26.3p26.2 containing CRBN gene in patients with intellectual disability and behavior abnormalities.

    Science.gov (United States)

    Papuc, Sorina M; Hackmann, Karl; Andrieux, Joris; Vincent-Delorme, Catherine; Budişteanu, Magdalena; Arghir, Aurora; Schrock, Evelin; Ţuţulan-Cuniţă, Andreea C; Di Donato, Nataliya

    2015-05-01

    We report on the clinical data and molecular cytogenetic findings in three unrelated patients presenting with intellectual disability and behavior abnormalities. An overlapping microduplication involving 3p26.2-26.3 was identified in these patients. All three aberrations were confirmed and proven to be parentally inherited. The sizes of the duplications were different, with a common minimal region of 423,754 bp containing two genes - TRNT1 and CRBN. Here, we hypothesize that the copy number gain of CRBN gene might be responsible for developmental delay/intellectual disability.

  2. Automatic Parallelization of Scientific Application

    DEFF Research Database (Denmark)

    Blum, Troels

    In my PhD work I show that it is possible to run unmodified Python/NumPy code on modern GPUs. This is done by using the Bohrium runtime system to translate the NumPy array operations into an array based bytecode sequence. Executing these byte-codes on two GPUs from different vendors shows great...... performance gains. Scientists working with computer simulations should be allowed to focus on their field of research and not spend excessive amounts of time learning exotic programming models and languages. We have with Bohrium achieved very promising results by starting out with a relatively simple approach....... This has lead to more specialized methods as I have shown with the work done with both specialized, and parametrizied kernels. Both have their benefits and recognizable use cases. We achieved clear performance benefits without any significant negative impact on overall application performance. Even...

  3. Battling memory requirements of array programming through streaming

    DEFF Research Database (Denmark)

    Kristensen, Mads Ruben Burgdorff; Avery, James Emil; Blum, Troels;

    2016-01-01

    A barrier to efficient array programming, for example in Python/NumPy, is that algorithms written as pure array operations completely without loops, while most efficient on small input, can lead to explosions in memory use. The present paper presents a solution to this problem using array streaming......, implemented in the automatic parallelization high-performance framework Bohrium. This makes it possible to use array programming in Python/NumPy code directly, even when the apparent memory requirement exceeds the machine capacity, since the automatic streaming eliminates the temporary memory overhead...... streaming, yielding corresponding improvements in speed and utilization of GPGPU-cores. The streaming-enabled Bohrium effortlessly runs programs on input sizes much beyond sizes that crash on pure NumPy due to exhausting system memory....

  4. 建立企业自己的“263邮局”(一)——操作系统也能提供邮件服务

    Institute of Scientific and Technical Information of China (English)

    王建春

    2003-01-01

    邮件服务在网络里的角色是越来越重要.不管是因特网上还是在局域网内部.大家都已经习惯使用电子邮件来处理日常的工作了.在Windows Server 2003出现之前,想在一台Windows NT Server或者Windows 2000 Server上构建一台邮件服务器是比较麻烦的事情.基本上是Windows NT 4.0 Server+Exchange 5.5 Server或者是Windows 2000

  5. Quality of Student Paper Sources Improves after Individual Consultation with Librarians. A Review of: Reinsfelder, T. L. (2012. Citation analysis as a tool to measure the impact of individual research consultations. College & Research Libraries, 73(3, 263-277.

    Directory of Open Access Journals (Sweden)

    Laura Newton Miller

    2013-06-01

    Full Text Available Objective – To determine whether the quality of sources used for a research paper will improve after a student receives one-on-one instruction with a librarian. To test citation analysis and a rating scale as means for measuring effectiveness of one-on-one consultations.Design – Citation analysis.Setting – Academic library of a large American university.Subjects – Papers from 10 courses were evaluated. In total, 76 students were asked to meet with librarians. Of these, 61 actually participated. Another 36 students from the control group were not asked to meet with a librarian (although 1 partook in a consultation.Methods – Librarians invited faculty to participate in a new service to help improve quality of student research papers. Eligible courses included those with a required research paper component where papers could be evaluated at different times in the project. Faculty instructed students in the class to meet with the librarian after a first draft of a paper was written. Students from seven courses were asked to meet with a librarian. Courses included English Composition (2, Geography (1, Child Development (1, Occupational Therapy (1, Marketing (1 and Women Writers (1. Three courses acted as control groups (all English Composition. After meeting with students to make recommendations, librarians used a rating scale (measuring relevancy, authority, appropriate dates and scope to review the quality of sources in both drafts and final papers.Main Results – One-on-one consultations with a librarian resulted in sources being of a higher quality in the final paper. With the exception of authority, the differences between draft and final paper were statistically significant in all measures (overall quality, relevance, dates and scope. Those in the control group showed no improvement in quality of sources between draft and final paper.Conclusion – Quality of sources in final paper improves after one-on-one consultations with librarians. The use of a rating scale is helpful in objectively measuring quality of sources, although there is potential for subjective interpretation.

  6. El Tribunal General de la UE clarifica el concepto de actos impugnables por los particulares según el artículo 263(4 TFUE: La sentencia “Microban”

    Directory of Open Access Journals (Sweden)

    Luis González Vaqué

    2012-01-01

    Full Text Available The General Court (Fourth Chamber, Extended Composition annulled Commission Decision 2010/169/EU of 19 March 2010 concerning the non-inclusion of 2,4,4’-trichloro-2’-hydroxydiphenyl ether in the Union list of additives which may be used in the manufacture of plastic materials and articles intended to come into contact with foodstuffs under Directive 2002/72/EC. The General Court concluded that the Commission infringed Regulation No 1935/2004 and Directive 2002/72 in adopting a decision not to include an additive solely on the basis of the withdrawal of the initial application for inclusion of triclosan in the positive list, in circumstances where there was no legal basis allowing the adoption of such a decision; and also declared that it could not be held that the contested decision entailed implementing measures: therefore declared that that decision constituted a regulatory act of direct concern to the applicants, which did not entail any implementing measures, so that the plea of inadmissibility raised by the Commission had to be dismissed without it being necessary to consider whether it was of individual concern to the applicants.

  7. Cytokine-induced inside-out activation of FcaR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor

    NARCIS (Netherlands)

    Bracke, M.S.G.M.; Lammers, J.W.J.; Coffer, P.J.; Koenderman, L.

    2002-01-01

    Fc receptors play an important role in leukocyte activation and the modulation of ligand binding ("activation") is a criti-cal point of regulation. Previous studies demonstrated that the Fc receptor for IgA (FcaRI/CD89) is regulated by cytokine stimulation, switching it to a high-binding state. To i

  8. Genome-wide scan of granular corneal dystrophy, type II: confirmation of chromosome 5q31 and identification of new co-segregated loci on chromosome 3q26.3

    OpenAIRE

    Lee, Eun-Ju; Kim, Kwang Joong; Kim, Han-Na; Bok, Jeong; Jung, Sung-Chul; Kim, Eung Kweon; Lee, Jong-Young; Kim, Hyung-Lae

    2011-01-01

    Granular corneal dystrophy, type II (CGD2; Avellino corneal dystrophy) is the most common corneal dystrophy among Koreans, but its pathophysiology is still poorly understood. Many reports showed that even though the causative mutation is the same TGFBI R124H mutation, there are severe and mild phenotypes of the corneal dystrophy. We also observed the phenotype differences in our samples. For this reason, we focused our effort on the identification of unknown genetic factor related to phenotyp...

  9. Spectroscopic, thermal, antimicrobial and molecular modeling studies of mononuclear pentafunctional Schiff base metal chelates derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione

    Science.gov (United States)

    Adly, Omima M. I.; Taha, Ali; Fahmy, Shery A.

    2015-03-01

    A new pentafunctional N3O2 Schiff base, H2L ligand, and its metal chelates with Cu(II), Ni(II), Co(II), VO(IV), Zn(II), Cd(II), Ce(III), Cr(III), Fe(III) and UO2(VI) have been synthesized and characterized by elemental analysis, spectral, molar conductance, magnetic and thermal gravimetric studies. The results showed that the complexes have octahedral geometry except UO2 complex which has pentagonal bipyramidal arrangement. The TGA analyses suggest high stability for most complexes followed by thermal decomposition in different steps. The kinetic and thermodynamic parameters for decomposition steps of metal complexes thermograms have been calculated. Molecular orbital calculations were performed for the ligand and its metal complexes by means of hyperchem 7.52 program on the bases of semiempirical PM3 level and the results were correlated with the experimental data. The antimicrobial activity of the synthesized compounds were tested in vitro against some Gram-positive and Gram-negative bacteria; yeast and fungus strains and the results were discussed in terms of extended Lewis acid-base interactions.

  10. Multibeam collection for M26-3: Multibeam data collected aboard Meteor from 1993-10-28 to 1993-11-20, departing from Unknown Port and returning to Unknown Port

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  11. Gclust Server: 85848 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 85848 CEL_C08H9.5_17535345 Cluster Sequences Related Sequences(263) 502 old-1: Overexpression Longevity...ences Related Sequences(263) Sequence length 502 Representative annotation old-1: Overexpression Longevity

  12. Drug: D08292 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08292 Drug Olaquindox (INN); Olaquindox [veterinary] (TN) C12H13N3O4 263.0906 263....2493 D08292.gif Antiinfective, antibacterial, veterinary Quinoxalin DNA synthesis inhibitor Antiinfectives [

  13. Dicty_cDB: Contig-U03456-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Query: 1 agcaatgtcaccaanctgtattnaatcatantccactngtattattattttnattcancc 60 |||||||...||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 1 agcaatgtcaccaanctgtattnaatcatantccactngtattattattttnattcan...tnaatcatantccactngtattattattttnattcancc 60 ||||||||||||||||||||||||||||||||||||||...|||||||||||||||||||||| Sbjct: 263 agcaatgtcaccaanctgtattnaatcatantccactngtattattattttnattcancc 204 Query: 61

  14. Reference Librarians use Electronic Sources Six Times More than Print Sources to Answer Patrons' Questions. A review of: Bradford, Jane T., Barbara Costello, and Robert Lenholt. “Reference Service in the Digital Age: An Analysis of Sources Used to Answer Reference Questions.” The Journal of Academic Librarianship 31.3 (May 2005: 263-72.

    Directory of Open Access Journals (Sweden)

    Lorie A. Kloda

    2006-06-01

    Full Text Available Objective – To test the hypothesis that electronic sources are used by librarians more often than print sources to answer questions at the reference desk. Design – Use study. Setting – Small, private university in the United States. Subjects – Five full-time and two part‐time librarians working at the reference desk for four months (two months in the fall of 2002, and two months in the spring of 2003. Methods – The study recorded every question asked by library patrons during the two study periods, with the exception of non‐library related directional questions and hardware problems. For each question recorded, librarians, while working solo at the reference desk, paraphrased the question and recorded the source(s used to answer each question. Although questions were recorded regardless of source – in person, via email, or by telephone – the medium in which each question was asked and answered was not recorded. For the first half of the study period (fall 2002 semester, librarians kept manual records that were subsequently transcribed into a spreadsheet by a student assistant. In the second half of the study period (spring 2003 semester, the librarians entered data directly into a spreadsheet. The study’s data monitor (who was also a study participant was responsible for ensuring the integrity of the data and for assigning a category to each source. The source category ‘librarian’ was problematic in that it was unclear whether or not the actual source of the answer was the librarian or a source located by the librarian. After the first half of the study, the procedure was changed to require that a reference librarian was to label a source used to answer a question as ‘librarian’ only if the answer came from a librarian’s own knowledge, and if it did not require consultation of an outside source. Categories were generated on the fly, as the data monitor reviewed the recorded questions and sources. By the end of the study, 23 categories had emerged. While all sources for answers were categorized, questions themselves were not. During the second part of the study, the gender of the patron asking the question at the reference desk was also recorded. Main results –The results for the fall 2002 and spring 2003 semesters were similar. For the entire study period, librarians used a total of 3,487 sources to answer 2,491 questions. Sources fell into 23 different categories. The top 5 categories used to answer reference questions were databases (23.92%, librarians (23.6%, library catalogue (15.03%, internal Web page (12.27%, and reference books (9.38%. The top five categories accounted for 84.2% of all sources used. For 75% of the questions, librarians referred to a single source for an answer. Almost 60% of the sources used to answer questions were electronic. Of the internal Web pages used to answer questions, the library’s online journal title listings accounted for 76%. Reference books were used to answer questions in less than 10% of cases. Less than 2% of the library’s print reference collection (173 of 9,587 titles was consulted to answer reference questions during the study period. The approximate 60:40 ratio of questions asked by female to male patrons corresponded to the university’s student body ratio. Conclusion – The results of this study confirm the researchers’ hypothesis that librarians use electronic sources with greater frequency than they use print sources to answer patrons’ reference questions. The surprising finding in this study is the proportion (approximately one quarter of reference questions answered by the librarians themselves, without the need to consult an outside source, either print or electronic. The study suggests that a large proportion of the reference collection goes unused in answering patrons’ questions and that librarians often answer a question using only a single a source of information. A reshelving study analyzing use of the reference collection is underway to supplement the results of the current study.

  15. Study of Search Engine Transaction Logs Shows Little Change in How Users use Search Engines. A review of: Jansen, Bernard J., and Amanda Spink. “How Are We Searching the World Wide Web? A Comparison of Nine Search Engine Transaction Logs.” Information Processing & Management 42.1 (2006: 248‐263.

    Directory of Open Access Journals (Sweden)

    David Hook

    2006-09-01

    Full Text Available Objective – To examine the interactions between users and search engines, and how they have changed over time. Design – Comparative analysis of search engine transaction logs. Setting – Nine major analyses of search engine transaction logs. Subjects – Nine web search engine studies (4 European, 5 American over a seven‐year period, covering the search engines Excite, Fireball, AltaVista, BWIE and AllTheWeb. Methods – The results from individual studies are compared by year of study for percentages of single query sessions, one term queries, operator (and, or, not, etc. usage and single result page viewing. As well, the authors group the search queries into eleven different topical categories and compare how the breakdown has changed over time. Main Results – Based on the percentage of single query sessions, it does not appear that the complexity of interactions has changed significantly for either the U.S.‐based or the European‐based search engines. As well, there was little change observed in the percentage of one‐term queries over the years of study for either the U.S.‐based or the European‐based search engines. Few users (generally less than 20% use Boolean or other operators in their queries, and these percentages have remained relatively stable. One area of noticeable change is in the percentage of users viewing only one results page, which has increased over the years of study. Based on the studies of the U.S.‐based search engines, the topical categories of ‘People, Place or Things’ and ‘Commerce, Travel, Employment or Economy’ are becoming more popular, while the categories of ‘Sex and Pornography’ and ‘Entertainment or Recreation’ are declining. Conclusions – The percentage of users viewing only one results page increased during the years of the study, while the percentages of single query sessions, oneterm sessions and operator usage remained stable. The increase in single result page viewing implies that users are tending to view fewer results per web query. There was also a significant difference in the percentage of queries using Boolean operators between the US‐based and the European‐based search engines. One of the study’s findings was that results from a study of a particular search engine cannot necessarily be applied to all search engines. Finally, web search topics show a trend towards information or commerce searching rather than entertainment.

  16. 水的过滤和电解净化Kojima,Yukimasa(Sogo Musen Y.K.,Japan)日本公开特许公报JP 2002 59,165 2002,2,263页(日文)

    Institute of Scientific and Technical Information of China (English)

    纪永亮

    2004-01-01

    在封闭区域中的水(如湖水、池塘水)的净化方法是:①通过竹碳滤料;②使过滤后的水不断流动;③用低压银电极电解水;④释放Ag离子浓度大约为60PPB的净化水。这样,不用药剂便可低成本的使水净化。

  17. Statistical Measures Alone Cannot Determine Which Database (BNI, CINAHL, MEDLINE, or EMBASE Is the Most Useful for Searching Undergraduate Nursing Topics. A Review of: Stokes, P., Foster, A., & Urquhart, C. (2009. Beyond relevance and recall: Testing new user-centred measures of database performance. Health Information and Libraries Journal, 26(3, 220-231.

    Directory of Open Access Journals (Sweden)

    Giovanna Badia

    2011-03-01

    Full Text Available Objective – The research project sought to determine which of four databases was the most useful for searching undergraduate nursing topics. Design – Comparative database evaluation. Setting – Nursing and midwifery students at Homerton School of Health Studies (now part of Anglia Ruskin University, Cambridge, United Kingdom, in 2005-2006. Subjects – The subjects were four databases: British Nursing Index (BNI, CINAHL, MEDLINE, and EMBASE.Methods – This was a comparative study using title searches to compare BNI (BritishNursing Index, CINAHL, MEDLINE and EMBASE.According to the authors, this is the first study to compare BNI with other databases. BNI is a database produced by British libraries that indexes the nursing and midwifery literature. It covers over 240 British journals, and includes references to articles from health sciences journals that are relevant to nurses and midwives (British Nursing Index, n.d..The researchers performed keyword searches in the title field of the four databases for the dissertation topics of nine nursing and midwifery students enrolled in undergraduate dissertation modules. The list of titles of journals articles on their topics were given to the students and they were asked to judge the relevancy of the citations. The title searches were evaluated in each of the databases using the following criteria: • precision (the number of relevant results obtained in the database for a search topic, divided by the total number of results obtained in the database search;• recall (the number of relevant results obtained in the database for a search topic, divided by the total number of relevant results obtained on that topic from all four database searches;• novelty (the number of relevant results that were unique in the database search, which was calculated as a percentage of the total number of relevant results found in the database;• originality (the number of unique relevant results obtained in the database for a search topic, which was calculated as a percentage of the total number of unique results found in all four database searches;• availability (the number of relevant full text articles obtained from the database search results, which was calculated as a percentage of the total number of relevant results found in the database;• retrievability (the number of relevant full text articles obtained from the database search results, which was calculated as a percentage of the total number of relevant full text articles found from all four database searches;• effectiveness (the probable odds that a database will obtain relevant search results;• efficiency (the probable odds that a database will obtain both unique and relevant search results; and• accessibility (the probable odds that the full text of the relevant references obtained from the database search are available electronically or in print via the user’s library.Students decided whether the search results were relevant to their topic by using a “yes/no” scale. Only record titles were used to make relevancy judgments.Main Results – Friedman’s Test and odds ratios were used to compare the performance of BNI, CINAHL, MEDLINE, and EMBASE when searching for information about nursing topics.These two statistical measures demonstrated the following:• BNI had the best average score for the precision, availability, effectiveness, and accessibility of search results;• CINAHL scored the highest for the novelty, retrievability, and efficiency of results, and ranked second place for all the other criteria;• MEDLINE excelled in the areas of recall and originality, and ranked second place for novelty and retrievability; and• EMBASE did not obtain the highest, or second highest score, for any of the criteria.Conclusion – According to the authors, these results suggest that none of the databases studied can be considered the most useful for searching undergraduate nursing topics. CINAHL and MEDLINE emerge as consistently good performers, but both databases are needed to find relevant material on a topic.Friedman’s Test clearly differentiated between the databases for the accessibility of search results. Odds ratio testing may assist librarians to make decisions about database purchases. BNI scored the highest for availability of results and CINAHL ranked the highest for retrievability. Statistical measures need to be supplemented with qualitative data about user preferences in order to determine which database is the most useful to our users.

  18. Dicty_cDB: Contig-U08964-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available uery: 826 tgtcgtttanataaatntcaaatgaacgttcanacatctttaatctctggnatctcctct 885 ||||||...|||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 826 tgtcgtttanataaatntcaaatgaacgttcanacatcttta...gcaaatanaaattcaagtanagtattggttnatttacatgaanacgtattggaaagt 323 Query: 826 tgtcgtttanataaatntcaaatgaacgttcanac...atctttaatctctggnatctcctct 885 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 322 tgtcgtttanataaatntcaaatgaacgttc...anacatctttaatctctggnatctcctct 263 Query: 886 gngctctttga

  19. 英文摘要

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Lunch with Warren Buffett setsnewrecord Thepriceofaprivatelunchwithrevered investorWarrenBuffetttoppedlastyear's bidonthefinaldayoftheweeklongcontest, after the winning bidder agreed to pay morethan$2.63million.

  20. Paul Scherrer Institute Scientific Report 1999. Volume I: Particles and Matter

    Energy Technology Data Exchange (ETDEWEB)

    Gobrecht, J.; Gaeggeler, H.; Herlach, D.; Junker, K.; Kettle, P.-R.; Kubik, P.; Zehnder, A. [eds.

    2000-07-01

    lthough originally planned for fundamental research in nuclear physics, the particle beams of pions, muons, protons and neutrons are now used in a large variety of disciplines in both natural science and medicine. The beams at PSI have the world's highest intensities and therefore allow certain experiments to be performed, which would not be possible elsewhere. The highlight of research this year was the first-ever determination of the chemical properties of the superheavy element {sup 107} Bohrium. This was undertaken, by an international team led by H. Gaeggeler of PSI's Laboratory for Radiochemistry. Bohrium was produced by bombarding a Berkelium target with Neon ions from the Injector I cyclotron and six atoms were detected after having passed through an online gas chromatography device. At the Laboratory for Particle Physics the focus has shifted from nuclear physics to elementary particle physics with about a fifty-fifty split between investigations of rare processes or particle decays using the high intensity muon, pion and recently also polarized neutron beams of PSI, and research at the highest energy frontier at CERN (Geneva) and DESY (Hamburg). Important space instrumentation has been contributed by the Laboratory for Astrophysics to the European Space Agency and NASA satellite programmes. The Laboratory for Micro and Nanotechnology continued to focus on research into molecular nanotechnology and SiGeC nanostructures, the latter with the aim of producing silicon based optoelectronics. Progress in 1999 in these topical areas is described in this report. A list of scientific publications in 1999 is also provided.

  1. 76 FR 54741 - Proposed Additions and Deletions

    Science.gov (United States)

    2011-09-02

    ... Logistics Agency Land and Maritime, Columbus, OH. Coverage: C-List for 100% of the requirement of the Department of Defense, as aggregated by the Defense Logistics Agency Land and Maritime, Columbus, OH.... NPA: ASPIRO, Inc., Green Bay, WI. NSN: 8340-00-263-0254. NSN: 8340-00-263-0255. NPA: Community...

  2. Chromosomal evolution of the PKD1 gene family in primates

    Directory of Open Access Journals (Sweden)

    Krawczak Michael

    2009-01-01

    Full Text Available Abstract Correction to Kirsch S, Pasantes J, Wolf A, Bogdanova N, Münch C, Pennekamp P, Krawczak M, Dworniczak B, Schempp W: Chromosomal evolution of the PKD1 gene family in primates. BMC Evolutionary Biology 2008, 8:263 (doi:10.1186/1471-2148-8-263

  3. GETDB: 113744 [GETDB

    Lifescience Database Archive (English)

    Full Text Available . (s.g.) abd. weak thorax - - comment1:C, comment2:63B-C d1 d2 d3 d4 e1 - - Show ...- Also known as - Original Comments comment1:C, comment2:63B-C Disc (Image) d1 d2 d3 d4 Disc (number) 4 Embr

  4. AcEST: DK961188 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 1.5 sp|P47505|Y263_MYCGE Uncharacterized protein MG263 OS=Mycoplasma... 32 1.9 sp|O94441|YPP1_SCHPO Putative cargo...DRFIEGINNIVKRFPEAAYKLNSGWIS 128 >sp|O94441|YPP1_SCHPO Putative cargo-transport protein ypp1 OS=Schizosacchar

  5. Drug: D02303 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02303 Drug Miloxacin (INN); MIL C12H9NO6 263.043 263.203 D02303.gif Veterinary vet...rinary D02303 Miloxacin (INN) CAS: 37065-29-5 PubChem: 7...itor type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor [KO:K02469 K02470 K02621 K02622] Other quinolones Miloxacin; Vete

  6. Dicty_cDB: VSK261 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available XXXXXXXXCCCNAAAAAAAAAAAAAAATAAAAAATAAAAA ATAAAAAAAGCAATTATTAATA sequence update 2001. 3.22 Translated Amino ...Seq.d/ 36 0.067 SSM263 (SSM263Q) /CSM/SS/SSM2-C/SSM263Q.Seq.d/ 36 0.067 own update 2003. 1.10 Homology vs DN...477258.1 603847884F1 CSEQRBN22 Gallus gallus cDNA clone ChEST839h22 5', mRNA sequence. 36 6.7 2 dna update 2... of Sequences: 3019103 Number of Hits to DB: 16,926,333 protein update 2009. 3.26 PSORT - 5' end seq. ID VSK

  7. Quinoa Well Tolerated in Patients with Celiac Disease

    Science.gov (United States)

    ... Quinoa Well Tolerated in Patients with Celiac Disease Quinoa Well Tolerated in Patients with Celiac Disease FOR ... 263-9000 Bethesda, Maryland (January 21, 2014) – Adding quinoa to the gluten-free diet of patients with ...

  8. 76 FR 20892 - Prohibition Against Payment of Interest on Demand Deposits

    Science.gov (United States)

    2011-04-14

    .... Allison, Senior Counsel (202/452-3565), Legal Division, or Joshua S. Louria, Financial Analyst (202/263... Advertising, Banks, Banking, Consumer protection, Reporting and recordkeeping requirements, Truth in...

  9. 76 FR 4084 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Science.gov (United States)

    2011-01-24

    ... for submitting comments. Mail: Rich Malinowski, Southeast Regional Office, NMFS, 263 13th Avenue South... CONTACT: Rich Malinowski, 727-824-5305; fax: 727-824-5308. SUPPLEMENTARY INFORMATION: The reef...

  10. Elementõ polititsheskoi mifologii Tjuttsheva (kommentari k state 1844 g.) / Aleksandr Ospovat

    Index Scriptorium Estoniae

    Ospovat, Aleksandr

    1999-01-01

    Bibl. lk. 259-263. Kokkuvõte inglise k. lk. 321. Kiri ajalehe "Allgemeine Zeitung" (Augsburg) toimetajale Gustav Kolbile (1844, prantsuse k.). Artikli venek. versioon (pealk. "Venemaa ja Saksamaa") publitseeriti ajakirjas Russki arhiv (1873, nr. 10)

  11. Drug: D04755 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Japan [BR:br08301] 2 Agents affecting individual organs 26 Epidermides 263 Suppurative dermatosis agents 2639 Others D04755 Bacitracin - fradiomycin sulfate mixt PubChem: 17398156 ...

  12. 75 FR 78617 - Final Flood Elevation Determinations

    Science.gov (United States)

    2010-12-16

    ... downstream of Martin Hot Spring County. Luther King Boulevard. Approximately 1,300 feet +263 downstream of Martin Luther King Boulevard. Town Creek Approximately 2,300 feet +253 Unincorporated Areas of...

  13. 77 FR 53214 - Announcement of Funding Awards; Service Coordinators in Multifamily Housing Program, Fiscal Year...

    Science.gov (United States)

    2012-08-31

    ... Antioch Haven Homes.. 420 W 63rd St........ Chicago 195 263,033 Ltd. IL Paul G. Stewart Paul G. Stewart... S. James St. and Dover 90 192,703 Dover II LP. & II. 139 Filmore St. OH Sturbridge Green...

  14. Integration of the information problem-solving skill in an educational programme: The effects of learning with authentic tasks.

    NARCIS (Netherlands)

    Brand-Gruwel, Saskia; Wopereis, Iwan

    2008-01-01

    Brand-Gruwel, S., & Wopereis, I. (2006). Integration of the information problem-solving skill in an educational programme: The effects of learning with authentic tasks. Technology, Instruction, Cognition, and Learning, 4, 243-263.

  15. Tenosynovitis

    Science.gov (United States)

    ... of the tendon sheath References Biundo JJ. Bursitis, tendinitis, and other periarticular disorders and sports medicine. In: ... Saunders; 2016:chap 263. Schmidt MJ, Adams SL. Tendinopathy and bursitis. In: Marx JA, Hockberger RS, Walls ...

  16. Genetics Home Reference: amyotrophic lateral sclerosis

    Science.gov (United States)

    ... Lattante S, Ciura S, Rouleau GA, Kabashi E. Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD). Trends Genet. 2015 May;31(5):263-73. ...

  17. 77 FR 63291 - Certain Orange Juice From Brazil: Final Results of Antidumping Duty Administrative Review and...

    Science.gov (United States)

    2012-10-16

    ... respondents in this administrative review (i.e., Fischer S.A. Comercio, Industria, and Agricultura (Fischer... 28, 2011: Percent Manufacturer/Exporter margin Sucocitrico Cutrale, S.A 2.63 Fischer S.A....

  18. 78 FR 59657 - Endangered Species; File No. 17304

    Science.gov (United States)

    2013-09-27

    ... Survey, 3205 College Ave., Davie, Florida, 33314 has been issued a permit to take loggerhead (Caretta..., MD 20910; phone (301)427-8401; fax (301)713-0376; and Southeast Region, NMFS, 263 13th Ave South,...

  19. Effect of radiation-induced substrate defects on microstrip gas chamber gain behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Pallares, A.; Brom, J.M.; Bergdolt, A.M.; Coffin, J.; Eberle, H.; Sigward, M.H. [Institute de Recherches Subatomiques, 67 - Strasbourg (France); Fontaine, J.C. [Universite de Haute Alsace, GRPHE, 61 rue Albert Camus, 68093 Mulhouse Cedex (France); Barthe, S.; Schunck, J.P. [Laboratoire PHASE (UPR 292 du CNRS), 23 rue du Loess, BP 28, 67037 Strasbourg Cedex 2 (France)

    1998-08-01

    The aim of this work was to quantify the influence of radiation-induced substrate defects on microstrip gas chamber (MSGC) gain behaviour. The first part of this paper focuses on radiation effects on a typical MSGC substrate: Desag D263 glass. Defect generation was studied for Desag D263 with pure silica (Suprasil 1) as a reference. We studied the evolution of defect concentration with respect to accumulated doses up to 480 kGy. Annealing studies of defects in Desag D263 were also performed. In the second part, the radiation sensitivity of Desag D263 glass has been linked to the behaviour of the detector under irradiation. Comparative gain measurements were taken before and after substrate irradiation at 10 and 80 kGy the minimal dose received during LHC operation and the dose for which defect density is maximum (respectively). (orig.) 26 refs.

  20. What to Expect During a Colonoscopy

    Medline Plus

    Full Text Available ... Institute Annual Reports Donation Form ACG Visiting Professor Network Clinical Research Funding Opportunities Junior Faculty Development Grants ... available for interviews upon request. Please call the Communications Team at 301-263-9000 or e-mail ...

  1. Data of evolutionary structure change: 1DJ2B-1ADIA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DJ2B-1ADIA 1DJ2 1ADI B A IGSLSQVSGVLGCQWGDEGKGKLVDILAQHFDIVARCQG...LLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADI...5 PHE CA 263 LYS CA 227 TYR CA 251 1ADI... A 1ADIA 1 1ADI A 1ADI

  2. Bryophytes from the area drained by the Peel and Mackenzie Rivers, Yukon and Northwest Territories, Canada

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report is on bryophytes from the area drained by the Peel and Mackenzie rivers in the Yukon territory of Canada. The distribution and general ecology of 263...

  3. Dicty_cDB: Contig-U14141-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tities = 257/263 (97%) Strand = Plus / Plus Query: 11 aatccnaaacctggnccccaatattatccccnancnactttnccnntatttgaa...tccccn 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 aatccna...aacctggnccccaatattatccccnancnactttnccnntatttgaatccccn 70 Query: 71 aangnttttganaaatttganatnganaccntgn...| Sbjct: 131 anttatcnacaanatcnagcagntaaannattaaanaaacaaggntggagntntnataaa 190 Query: 191 aaanatntcncctggnttanaanacatgaagnaccna...aanaaatnccnaangaatttgaa 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| S

  4. Drug: D00213 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available individual organs 26 Epidermides 263 Suppurative dermatosis agents 2634 Antibiotics...ate (JP16); Fusidate sodium (USAN) S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics

  5. Drug: D00290 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ual organs 26 Epidermides 263 Suppurative dermatosis agents 2634 Antibiotics for external use D00290 Demethy...nts against pathologic organisms and parasites 61 Antibiotics 615 Acting mainly on gram-positive bacteria, g

  6. EST Table: FS895931 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS895931 E_FL_ftes_20D04_R_0 10/09/28 48 %/263 aa ref|XP_975194.1| PREDICTED: similar to something about.../309 aa gnl|Amel|GB19080-PA 10/09/10 48 %/263 aa gi|91081571|ref|XP_975194.1| PREDICTED: similar to something about silencing protein 10 [Tribolium castaneum] FS823506 ftes ...

  7. Drug: D07793 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07793 Drug Desvenlafaxine (INN) C16H25NO2 263.1885 263.3752 D07793.gif Antidepress...ynapse CYP inhibition: CYP2D6 [HSA:1565] map07027 Antidepressants map07234 Neurot...S SYSTEM N06 PSYCHOANALEPTICS N06A ANTIDEPRESSANTS N06AX Other antidepressants N06AX23 Desvenlafaxine D07793... Desvenlafaxine (INN) USP drug classification [BR:br08302] Antidepressants SSRIs/

  8. Drug: D08288 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08288 Drug Nortriptyline (INN); Nortrilen (TN) C19H21N 263.1674 263.3767 D08288.gif Antidepress...ant, tricyclic Same as: C07274 ATC code: N06AA10 Tricyclic antidepressants serotonin transporte... Serotonergic synapse Enzyme: CYP2D6 [HSA:1565] Genomic biomarker: CYP2D6 [HSA:1565] map07027 Antidepress... D08288 Nortriptyline (INN) USP drug classification [BR:br08302] Antidepressants Tricyclics Nortriptyline D0

  9. The comparative effect of an addition of a surface term to the Woods-Saxon potential on the thermodynamics of a nucleon

    CERN Document Server

    Lütfüoğlu, B C

    2016-01-01

    In this study, we reveal the difference between Woods-Saxon (WS) and Generalized Symmetric Woods-Saxon (GSWS) potentials in order to describe the physical properties of a nucleon, by means of solving Schr\\"odinger equation for the two potentials. The additional term squeezes the WS potential well, which leads an upward shift in the spectrum, resulting in a more realistic picture. The resulting GSWS potential does not merely accommodate extra quasi bound states, but also has modified bound state spectrum. As an application, we apply the formalism to a real problem, an $\\alpha$ particle confined in Bohrium-$270$ nucleus. The thermodynamic functions Helmholtz energy, entropy, internal energy, specific heat of the system are calculated and compared in both wells. The internal energy and the specific heat capacity increase, as a result of upward shift in the spectrum. The shift of the Helmholtz free energy is a direct consequence of the shift of the spectrum. The entropy decreases because of a decrement in the num...

  10. A critical HA1 neutralizing domain of H5N1 influenza in an optimal conformation induces strong cross-protection.

    Directory of Open Access Journals (Sweden)

    Lanying Du

    Full Text Available The highly pathogenic avian influenza (HPAI H5N1 viruses, especially the laboratory-generated H5N1 mutants, have demonstrated the potential to cross the species barrier and infect mammals and humans. Consequently, the design of an effective and safe anti-H5N1 vaccine is essential. We previously demonstrated that the full-length hemagglutinin 1 (HA1 could induce significant neutralizing antibody response and protection. Here, we intended to identify the critical neutralizing domain (CND in an optimal conformation that can elicit strong cross-neutralizing antibodies and protection against divergent H5N1 strains. We thus constructed six recombinant proteins covering different regions of HA1 of A/Anhui/1/2005(H5N1, each of which was fused with foldon (Fd and Fc of human IgG. We found that the critical fragment fused with Fd/Fc (HA-13-263-Fdc, H5 numbering that could elicit the strongest neutralizing antibody response is located in the N-terminal region of HA1 (residues 13-263, which covers the receptor-binding domain (RBD, residues 112-263. We then constructed three additional recombinants fused with Fd plus His tag (HA-13-263-Fd-His, Fc only (HA-13-263-Fc, and His tag only (HA-13-263-His, respectively. We found that the HA-13-263-Fdc, which formed an oligomeric conformation, induced the strongest neutralizing antibody response and cross-protection against challenges of two tested H5N1 virus strains covering clade 1: A/VietNam/1194/2004 (VN/1194 or clade 2.3.4: A/Shenzhen/406H/06 (SZ/406H, while HA-13-263-Fc dimer and HA-13-263-Fd-His trimer elicited higher neutralizing antibody response and protection than HA-13-263-His monomer. These results suggest that the oligomeric form of the CND containing the RBD can be further developed as an effective and safe vaccine for cross-protection against divergent strains of H5N1 viruses.

  11. Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263, metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.

    Directory of Open Access Journals (Sweden)

    Derek J Nunez

    Full Text Available GPR119 receptor agonists improve glucose metabolism and alter gut hormone profiles in animal models and healthy subjects. We therefore investigated the pharmacology of GSK1292263 (GSK263, a selective GPR119 agonist, in two randomized, placebo-controlled studies that enrolled subjects with type 2 diabetes. Study 1 had drug-naive subjects or subjects who had stopped their diabetic medications, and Study 2 had subjects taking metformin. GSK263 was administered as single (25-800 mg; n = 45 or multiple doses (100-600 mg/day for 14 days; n = 96. Placebo and sitagliptin 100 mg/day were administered as comparators. In Study 1, sitagliptin was co-administered with GSK263 or placebo on Day 14 of dosing. Oral glucose and meal challenges were used to assess the effects on plasma glucose, insulin, C-peptide, glucagon, peptide tyrosine-tyrosine (PYY, glucagon-like peptide-1 (GLP-1 and glucose-dependent insulinotropic peptide (GIP. After 13 days of dosing, GSK263 significantly increased plasma total PYY levels by ∼ five-fold compared with placebo, reaching peak concentrations of ∼ 50 pM after each of the three standardized meals with the 300 mg BID dose. Co-dosing of GSK263 and metformin augmented peak concentrations to ∼ 100 pM at lunchtime. GSK263 had no effect on active or total GLP-1 or GIP, but co-dosing with metformin increased post-prandial total GLP-1, with little effect on active GLP-1. Sitagliptin increased active GLP-1, but caused a profound suppression of total PYY, GLP-1, and GIP when dosed alone or with GSK263. This suppression of peptides was reduced when sitagliptin was co-dosed with metformin. GSK263 had no significant effect on circulating glucose, insulin, C-peptide or glucagon levels. We conclude that GSK263 did not improve glucose control in type 2 diabetics, but it had profound effects on circulating PYY. The gut hormone effects of this GPR119 agonist were modulated when co-dosed with metformin and sitagliptin. Metformin may

  12. FTIR and EXAFS investigations of microstructures of gold solvent extraction:hydrogen bonding between modifier and Au(CN)2—

    Institute of Scientific and Technical Information of China (English)

    GangMa; TiandouHu; 等

    1999-01-01

    The microstructures of loaded organic phases of three quaternary amine solvent extraction systems for gold,which were N263-xylene,N263-tributyl phosphate(TBP)-dodecane and N263-2 -ethylhexanol (isooctanol)-dodecane(N263-trialkylmethylammonium chloride;alkyl=C8-C10),were studied by Fourier transform infrared (FTIR) spectroscopy and extended X-ray abso\\rption fine structure(EXAFS) spectroscopy. According to the EXAFS results,it was found that the gold coordination environment was the same before and after extraction.However,the C≡N stretching vibrations of Au(CN)2-were also found to be different,In order to explain the differences in the IR characteristics of C≡N in the three extraction systems,three microstructure models are proposed.For the N263-xylene system,the model is a simple ion pair.For the other two systems with a modifier(TBP and isooctanol),the models are two supramolecular structues based on hydrogen bonding between the modifier and Au(CN)2-.Some related work such as on the hydration of acetonitrile and the fine structure of C≡N in solid K Au(CN)2 was also performed in order to offer additional supporting evidence for the reliability of the proposed models.

  13. Adaptive optics imaging of the MBM 12 association

    CERN Document Server

    Chauvin, G; Fusco, T; Lagrange, A M; Beuzit, J L; Mouillet, D; Augereau, J C

    2002-01-01

    We report adaptive optics (AO) observations of the young and nearby association MBM 12 obtained with the Canada-France-Hawaii Telescope. Our main observational result is the discovery of six new binary systems, LkHa 264, E 0255+2018, RX J0255.4+2005, S18, MBM 12-10, RX J0255.3+1915, and the confirmation of HD 17332, already known as a binary. We also detected a possible quadruple system. It is composed of the close binary LkHa 263 AB (separation of 0.41 ''), of LkH\\alpha 262 located 15.25 '' from LkHa 263 A, and of LkHa 263 C, located 4.1 '' from LkH\\alpha 263 A. A preliminary study of the binary fraction suggests a binary excess in the MBM 12 association as compared to the field and IC 348. Because of the high binarity rate, previous estimations of spectral types and measurements of IR excesses for several candidate members of MBM 12 have to be revised. LkH\\alpha 263 C is a nebulous object that we interpret as a disk oriented almost perfectly edge-on and seen in scattered light. This object has already been ...

  14. Ion implantation for figure correction of thin X-ray telescope mirror substrates

    Science.gov (United States)

    Chalifoux, Brandon; Wright, Graham; Heilmann, Ralf K.; Schattenburg, Mark L.

    2015-09-01

    Figure correction of X-ray telescope mirrors will be critical for future missions that require high angular resolution and large collecting areas. In this paper, we show that ion implantation offers a method of correcting figure errors by imparting sub-surface in-plane stress in a controllable magnitude and location in Schott D-263 glass, Corning Eagle XG glass, and crystalline silicon substrates. In addition, we can in theory achieve nearly exact corrections in Schott D-263 glass, by controlling the direction of the stress. We show that sufficient stress may be applied to Schott D-263 glass to achieve figure correction in mirrors with simulated initial figure errors. We also report on progress of a system that will be capable of correcting conical shell mirror substrates.

  15. H+CO 2→OH+CO: Yield versus HI photolysls wavelength and OH rotational distributions under single-collision conditions and with CO 2HI complexes

    Science.gov (United States)

    Chen, Y.; Hoffmann, G.; Oh, D.; Wittig, C.

    1989-07-01

    The title reaction was studied under single-collision conditions using 227-285 nm HI photolysis. A large decrease in the OH yield was observed as the photolysis wavelength was increased. Rotational distributions were obtained at 227, 239, 251, 263 and 280 nm. Similar yield versus wavelength data were obtained for CO 2HI complexes (233-263 nm). The OH rotational distribution obtained using 239 nm CO 2HI photolysis differs markedly from its single-collision H+CO 2 counterpart.

  16. Mechanism of gold solvent extraction from aurocyanide solution by quaternary amines: models of extracting species based on hydrogen bonding

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The mechanism of gold solvent extraction from KAu(CN)2 solution was investigated by means of FTIR, EXAFS, ICP and radioactive tracer methods. Two extraction systems were studied, namely N263-tributyl phosphate(TBP)-n-dodecane and N263-iso-octanol-n-dodecane. High-reso- lution FT IR spectroscopy indicated that the CN stretching vibrations of the two extraction systems differred greatly. In order to interpret the significant difference in CN stretching vibrations, two extracting species models are proposed supramolecular structures based on the formation of hydrogen bonds between Au(CN)2- and modifiers such as TBP and iso-octanol.

  17. The DUV Stability of Superlattice-Doped CMOS Detector Arrays

    Science.gov (United States)

    Hoenk, M. E.; Carver, A. G.; Jones, T.; Dickie, M.; Cheng, P.; Greer, H. F.; Nikzad, S.; Sgro, J.; Tsur, S.

    2013-01-01

    JPL and Alacron have recently developed a high performance, DUV camera with a superlattice doped CMOS imaging detector. Supperlattice doped detectors achieve nearly 100% internal quantum efficiency in the deep and far ultraviolet, and a single layer, Al2O3 antireflection coating enables 64% external quantum efficiency at 263nm. In lifetime tests performed at Applied Materials using 263 nm pulsed, solid state and 193 nm pulsed excimer laser, the quantum efficiency and dark current of the JPL/Alacron camera remained stable to better than 1% precision during long-term exposure to several billion laser pulses, with no measurable degradation, no blooming and no image memory at 1000 fps.

  18. Mechanism of gold solvent extraction from aurocyanide solution by quaternary amines: models of extracting species based on hydrogen bonding

    Institute of Scientific and Technical Information of China (English)

    马刚; 闫文飞; 陈景; 严纯华; 高宏成; 周维金; 施鼐; 吴谨光; 徐光宪; 黄昆; 余建民; 崔宁

    2000-01-01

    The mechanism of gold solvent extraction from KAu(CN)2 solution was investigated by means of FTIR, EXAFS, ICP and radioactive tracer methods. Two extraction systems were studied, namely N263-tributyl phosphate(TBP)-n-dodecane and N263-iso-octanol-n-dodecane. High-resolution FT IR spectroscopy indicated that the CN stretching vibrations of the two extraction systems differred greatly. In order to interpret the significant difference in CN stretching vibrations, twoextracting species models are proposed——supramolecular structures based on the formation ofhydrogen bonds between Au(CN)2- and modifiers such as TBP and iso-octanol.

  19. Nationwide German Multicenter Study on the Prevalence of Antibiotic Resistance in Streptococcal Blood Isolates from Neutropenic Patients and Comparative In Vitro Activities of Quinupristin-Dalfopristin and Eight Other Antimicrobials

    OpenAIRE

    Reinert, Ralf René; Von Eiff, Christof; Kresken, Michael; Brauers, Johannes; Hafner, Dieter; Al-Lahham, Adnan; Schorn, Holger; Lütticken, Rudolf; Peters, Georg

    2001-01-01

    In a prospective multicenter study (1996 to 1999), 156 episodes of bacteremic streptococcal infections of neutropenic patients were evaluated. Streptococcus oralis (26.3%), S. pneumoniae (26.3%), S. agalactiae (11.5%), S. mitis (9%), and S. pyogenes (5.8%) were the predominant species. Four strains (2.6%) were found to be intermediately resistant to penicillin. One strain (0.6%) was found to be highly resistant to penicillin (MIC, 8 mg/liter). Reduced susceptibility to penicillin was detected...

  20. Genetic polymorphism of T6235C mutation in 3 non-coding region of CYP1A1 and GSTM1 genes and lung cancer susceptibility in the Mongolian population

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Objective To estimate the relative risk for lung cancer associated with genetic polymorphism of T6235C mutation in 3' non-coding region(MspⅠ)of cytochrome P450 1A1(CYP1A1)and glutathione S-transferase M1(GSTM1)in the Mongolian population in Inner Mongolian Region of China.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and multiplex PCR methods were used to analyze blood samples obtained from 263 case subjects and 263 control subjects to determine their genotypes for CYP1...

  1. Correlation between colorectal cancer and Helicobacter pylori infection%结直肠癌与幽门螺杆菌感染的相关性

    Institute of Scientific and Technical Information of China (English)

    高峰; 张玲

    2015-01-01

    目的 探讨H.pylori感染与结直肠癌之间的关系.方法 选取2008年1月至2014年1月病理确诊为结直肠癌的患者263例,作为结直肠癌组;另选取同期行结肠镜检查显示肠黏膜正常的患者263例,作为对照组.回顾性分析两组的H.pylori感染率,不同病理类型结直肠癌患者的H.pylori感染率,H.pylori感染伴萎缩性胃炎的发生率和H.pylori感染伴肠上皮化生的发生率,比较近端结肠癌和远端结直肠癌的H.pylori感染情况.比较采用卡方检验,并计算OR值及其95%CI.结果 263例结直肠癌患者中,结直肠癌组H.pylori感染率为63.50%(167/263),高于对照组的39.54%(104/263),差异有统计学意义(x2=27.66,OR=2.66,95%CI 1.85~3.83,P<0.01).不同病理类型结直肠癌患者中的H.pylori感染率差异无统计学意义(x2=0.15,P=0.93).结直肠癌患者中H.pylori感染伴萎缩性胃炎的发生率为46.39%(122/263),高于对照组的23.57%(62/263),差异有统计学意义(x2=28.53,OR=2.94,95%CI 1.98~4.36,P<0.01).结直肠癌患者中H.pylori感染伴肠上皮化生的发生率为17.87%(47/263),高于对照组的4.18%(11/263),差异有统计学意义(x2=23.56,OR=5.50,95%CI 2.76~10.95,P<0.01).近端结肠癌和远端结直肠癌的H.pylori感染率差异无统计学意义(x2=1.48,P=0.22).结论 H.pylori感染及其所致的萎缩性胃炎及肠上皮化生与结直肠癌相关.%Objective To explore the correlation between Helicobacter pylori (H.pylori) infection and colorectal cancer.Methods From January 2008 to January 2014,263 patients pathologically diagnosed as colorectal cancer were selected as colorectal cancer group,and at the same period 263 patients with normal colon mucosa under colonoscopy were set as control group.The rates of H.pylori infection,the rates of H.pylori infection in patients with different pathological types of colorectal cancer,the rates of H.pylori infection accompanied with atrophic gastritis and the rates of H

  2. Properties of Group Five and Group Seven transactinium elements

    Energy Technology Data Exchange (ETDEWEB)

    Wilk, Philip A.

    2001-05-01

    The detection and positive identification of the short-lived, low cross section isotopes used in the chemical studies of the heaviest elements are usually accomplished by measuring their alpha-decay, thus the nuclear properties of the heaviest elements must be examined simultaneously with their chemical properties. The isotopes 224 Pa and 266,267 Bh have been studied extensively as an integral part of the investigation of the heaviest members of the groups five and seven of the periodic table. The half-life of 224 Pa was determined to be 855 plus/minus19 ms by measuring its alpha-decay using our rotating wheel, solid state detector system at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. Protactinium was produced by bombardment of a bismuth target. New neutron rich isotopes, 267 Bh and 266 Bh, were produced in bombardments of a 249 Bk target and their decay was observed using the rotating wheel system. The 266 Bh that was produced decays with a half-life of approximately 1 s by emission of alpha particles with an average energy of 9.25 plus/minus 0.03 MeV. 267 Bh was observed to decay with a 17 s half-life by emission of alpha-particles with an average energy of 8.83 plus/minus 0.03 MeV. The chemical behavior of hafnium, Ha (element 105) was investigated using the fast on-line continuous liquid extraction and detection system SISAK-LISSY. Hafnium was not observed in this experiment following transport and extraction. Protactinium was used as on-line test of the apparatus to determine the experimental efficiency of the entire system. Unfortunately, the amount of protactinium observed after the extraction, compared to the amount produced, was extremely small, only 2.5%. The extraction of the protactinium isotope indicated the efficiency of the apparatus was too low to observe the extraction of hafnium. The chemical behavior of oxychloride compounds of bohrium was investigated by isothermal gas adsorption chromatography in a quartz column at 180, 150

  3. An experimental paradigm opening the world of superheavy elements

    Science.gov (United States)

    Armbruster, P.; Münzenberg, Gottfried

    2012-07-01

    The history of the discovery of the six elements Z = 107 ∓ 112, bohrium, hassium, meitnerium, darmstadtium, roentgenium, and copernicium goes back to the early 1960s. An experimental method to separate and identify rare nuclear reaction products, the recoil separation, was developed and optimised for beams of fission products at European research reactors. Chemical elements beyond the then first transactinides ( Z = 104), which owe their stability to the internal structure of atomic nuclei, were predicted theoretically. A big brother of the shell-stabilised nucleus 208Pb, a spherical magic nucleus at Z = 114∓126 and N = 184, might reach lifetimes long enough to be detected. In the seventies, hunting superheavy elements (SHE) was on the agenda of nuclear chemistry. Could the Periodic Table of Elements be extended to Z = 120, and is the order of electrons in the atom still following the laws established for lighter elements? In Germany, the heavy ion accelerator (UNILAC) was built by Christoph Schmelzer and his team at GSI, Darmstadt. SHE and UNILAC met the recoil separators in 1968, and SHIP (Separator for Heavy Ion reaction Products) was ready together with the first UNILAC-beams in 1976. Recoil separation is orders of magnitude more sensitive, selective, and faster than earlier methods used to synthesise elements up to seaborgium, Z = 106. The experimental paradigm we introduced opened the world of SHEs. At SHIP we discovered and investigated the elements Z = 107∓112 in the years 1980-2000. Our laboratory was the world champion during this time. Today our experimental method is used worldwide in the search for SHEs, but the leadership went to the Russian laboratory JINR in Dubna, which extended the Periodic Table by 6 more elements to Z = 118, the candidate for the next rare gas.

  4. Synthesis of the heaviest nuclei in cold fusion reactions

    Science.gov (United States)

    Münzenberg, G.; Morita, K.

    2015-12-01

    Cold fusion of heavy ions paved the way to superheavy elements. It was proposed by Yu.Ts. Oganessian more than forty years ago in 1974 [1,2]. First experiments were carried out at JINR Dubna, starting with the reaction 40Ar + 208Pb → 248Fm* where several hundreds to thousand atoms were produced on one day. The large production rate indicating an enhancement of the fusion cross section, especially for the evaporation of two or three neutrons, proved the concept of cold-fusion with the use of the doubly magic nucleus 208Pb as a target. The Dubna experiments were extended to the transactinide region beyond rutherfordium. The breakthrough came with the separation in-flight. Two different approaches were used: kinematic separation with the velocity filter SHIP [3] at GSI Darmstadt, and with the gasfilled separator GARIS [4,5] at RIKEN. With SHIP the concept of cold fusion of massive nuclear systems was convincingly confirmed by the observation of the one-neutron evaporation channel in the production of 247Rf in an irradiation of 208Pb with 50Ti [6] in 1981 which opened the way to the transactinide region. At SHIP the elements bohrium (107) to copernicium (112) were discovered [7]. A new closed shell region around hassium was found. The RIKEN experiments started in 2002. They confirmed the GSI results and in addition improved the data on structure and production of elements hassium to copernicium significantly. The heaviest element ever created in a cold fusion reaction, Z = 113, was observed at GARIS [8,9].

  5. Use of osteoplastic material to guide bone tissue regeneration deffect.

    Science.gov (United States)

    Machavariani, A; Mazmishvili, K; Grdzelidze, T; Menabde, G; Amiranashvili, I

    2011-12-01

    The goal of research was study of restoration processes in jaw-teeth bone defects by application of osteoplastic materials in the experiment. The experiment was performed over 32 white (6-12 month old) rats; the animals were divided into 2 groups; 16 animals were enrolled in the first group; the section was performed in the edge of lower jaw; the lower jaw body was revealed. Under the effect of the dental drilling machine and the # 1 cooling mean by the fissure bohrium (distilled water) the defect of the dimension of 2x2 mm was created; the defect was washed by 0/9% saline to remove the bone sawdust; the wound was sutured tightly, in layers. The second group of the experiment was staffed with 16 animals (main group); the similar bone defect of the size 2 x 2mm was created on the rat's jaw's body. After washing of modeled defect we inserted osteopathic materials PORESORB-TCP crystals with the size of 0,6-1.0 mm the wound was sutured tightly, in layers. After the 3-rd, 15-th, 30-th and 90-th days from the date of operation there was performed X-ray and morphological examination over the animals in the control as well as the main group. The analysis of the examination performed over the experimental materials showed that in the control group in samples taken at 90th day the defects were not completely restored. In the test group in samples taken at 90th day reparative regeneration is confirmed. This is stimulated by the factor that within the main group's animals the defect regeneration process is supported with the osteoplastic material PORESORB-TCP.

  6. Cardiac arrhythmias

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    2010315 Effects on electrical restitution of given esanolol during cardiopulmonary resuscitation in a swine ventricular fibrillation model. WEI Jie(魏捷),et al. Dept Emerg Med,Renmin Hosp,Wuhan Univ,Wuhan 430060.Chin J Emerg Med 2010;19(3):257-263. Objective To

  7. 77 FR 65256 - IFR Altitudes; Miscellaneous Amendments

    Science.gov (United States)

    2012-10-26

    ... MEA Sec. 95.6001 VICTOR ROUTES--U.S. Sec. 95.6001 VOR FEDERAL AIRWAY V1 Is Amended to Read in Part... FEDERAL AIRWAY V263 Is Amended To Read in Part HUGO, CO VOR/DME *LIMEX, CO FIX **10000 *10000--MRA...

  8. What to Expect During a Colonoscopy

    Medline Plus

    Full Text Available ... Update Newsletter ACG SmartBrief Constitution and Bylaws @ACG Digital Guide ACG Affinity Programs ACG Resources International Affiliate ... available for interviews upon request. Please call the Communications Team at 301-263-9000 or e-mail ...

  9. Changes in Racial Identity among African American College Students Following the Election of Barack Obama

    Science.gov (United States)

    Fuller-Rowell, Thomas E.; Burrow, Anthony L.; Ong, Anthony D.

    2011-01-01

    The current study considered the influence of the 2008 presidential election on the racial identity of African American college students (M[subscript age] = 19.3 years; 26.3% male). The design of the study consisted of 2 components: longitudinal and daily. The longitudinal component assessed 3 dimensions of racial identity (centrality, private…

  10. 77 FR 65773 - Reserve Requirements of Depository Institutions

    Science.gov (United States)

    2012-10-31

    ..., as prescribed by Board regulations, for the purpose of implementing monetary policy. Section 11(a)(2... liabilities and assets from depository institutions to enable the Board to conduct monetary policy. The Board... Monetary Affairs; for users of Telecommunications Device for the Deaf (TDD) only, contact (202/263-...

  11. The Relationship of the Murphy-Meisgeier Type Indicator for Children to Sex, Race, and Fluid-Crystallized Intelligence on the KAIT at Ages 11 to 15.

    Science.gov (United States)

    Kaufman, Alan S.; McLean, James E.

    1994-01-01

    Four typologies assessed by the Murphy-Meisgeier Type Indicator for Children (C. Meisgeier and M. Murphy, 1987) (Extraversion-Introversion, Sensing-Intuition, Thinking-Feeling, Judging-Perceiving) were related to sex, race/ethnic group, intelligence level, and fluid/crystallized IQ discrepancy for 263 adolescents. The Thinking/Feeling index…

  12. 21 CFR 522.460 - Cloprostenol sodium.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Cloprostenol sodium. 522.460 Section 522.460 Food... Cloprostenol sodium. (a)(1) Specifications. Each milliliter of the aqueous solution contains 263 micrograms of cloprostenol sodium (equivalent to 250 micrograms of cloprostenol) in a sodium citrate, anhydrous citric...

  13. IGNEOUS PETROLOGY

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>20090158 Bai Daoyuan (Hunan Institute of Geological Survey, Xiangtan 411100, China); Zhou Liang Genesis and Tectonic Setting of Indosinian Granites in Southeast Hunan Province (Acta Petrologica et Mineralogica, ISSN1000-6524, CN11-1966/P, 26(3), 2007, p.197-212, 8 illus., 3 tables, 77 refs.)

  14. 20 CFR 628.545 - Linkages and coordination.

    Science.gov (United States)

    2010-04-01

    ... the extent practicable, and as permitted by law and regulations, the Governor shall, at the State... sections 263(g) and 265(d) of the Act, the SDA shall establish a cooperative agreement with the appropriate... section, the cooperative agreement shall include: (i) A description of the ways in which the...

  15. Data of evolutionary structure change: 1AIJS-2UWTL [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1AIJS-2UWTL 1AIJ 2UWT S L YQNIFSQVQVRGPADLGMTEDVNLANRSGVGPFSTLLGW...t> 0 1AIJ S 1AIJ...fEVID> 1 1AIJ S 1AIJ...> LEU CA 183 PHE CA 263 1AIJ S 1AIJS VGPFSTLLGWFG

  16. Data of evolutionary structure change: 1DS8L-1AIJM [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DS8L-1AIJM 1DS8 1AIJ L M --------------ALLSFERKYRVPGGTL-------VG...A 245 SER CA 310 ALA CA 263 VAL CA 196 1AIJ... M 1AIJMLEU CA 264 ALA CA 260 LYS CA 280 1AIJ... M 1AIJM YGLSFAAPLKE

  17. Network Correlates of Sexual Health Advice Seeking and Substance Use among Members of the Los Angeles House and Ball Communities

    Science.gov (United States)

    Holloway, Ian W.; Schrager, Sheree M.; Wong, Carolyn F.; Dunlap, Shannon L.; Kipke, Michele D.

    2014-01-01

    House and Ball communities (HBCs), represent a prime context for human immunodeficiency virus prevention with African American young men who have sex with men and transgender persons. This study sought to understand the composition and function of social support and sexual networks of HBC members in Los Angeles, California (N = 263). Participants…

  18. 12 CFR 26.5 - Small market share exemption.

    Science.gov (United States)

    2010-01-01

    ... Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.5 Small market share exemption. (a) Exemption. A management interlock that is prohibited by § 26.3... recent annual Summary of Deposits published by the FDIC for the RMSA or community. (b) Confirmation...

  19. [Identification of Hydrocarbon-Oxidizing Dietzia Bacteria from Petroleum Reservoirs Based on Phenotypic Properties and Analysis of the 16S rRNA and gyrB Genes].

    Science.gov (United States)

    Nazina, T N; Shumkova, E S; Sokolova, D Sh; Babich, T L; Zhurina, M V; Xue, Yan-Fen; Osipov, G A; Poltaraus, A B; Tourova, T P

    2015-01-01

    The taxonomic position of hydrocarbon-oxidizing bacterial strains 263 and 32d isolated from formation water of the Daqing petroleum reservoir (PRC) was determined by polyphasic taxonomy techniques, including analysis of the 16S rRNA and the gyrB genes. The major chemotaxonomic characteristics of both strains, including the IV type cell wall, composition of cell wall fatty acids, mycolic acids, and menaquinones, agreed with those typical of Dietzia strains. The DNA G+C content of strains 263 and 32d were 67.8 and 67.6 mol%, respectively. Phylogenetic analysis of the 16S rRNA gene of strain 32d revealed 99.7% similarity to the gene of D. maris, making it possible to identify strain 32d as belonging to this species. The 16S rRNA gene sequence of strain 263 exhibited 99.7 and 99.9% similarity to those of D. natronolimnaea and D. cercidiphylli YIM65002(T), respectively. Analysis of the gyrB genes of the subterranean isolates and of a number of Dietzia type strains confirmed classiffication of strain 32d as a D. maris strain and of strain 263, as a D. natronolimnaea strain. A conclusion was made concerning higher resolving power of phylogenetic analysis of the gyrB gene compared to the 16S rRNA gene analysis in the case of determination of the species position of Dietzia isolates.

  20. AcEST: DK963392 [AcEST

    Lifescience Database Archive (English)

    Full Text Available =... 32 2.6 sp|P23009|POL2_BPMV RNA2 polyprotein OS=Bean-pod mottle virus (s... 31 3.4 sp|Q6ZM86|GRD2I_DANRE...REK 263 >sp|P23009|POL2_BPMV RNA2 polyprotein OS=Bean-pod mottle virus (strain Ke

  1. Disease: H00372 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ) PMID:3319266 (description, drug) Jezek Z, Khodakevich LN, Wickett JF Smallpox and its post-eradication surveillance. Bull World Hea...lth Organ 65:425-34 (1987) PMID:9795781 (description, env_factor) Ellner PD Smallpox: gone but not forgotten. Infection 26:263-9 (1998) ...

  2. Proceedings of the Annual Seismic Research Symposium (15th) Held in Vail, Colorado on 8-10 September 1993

    Science.gov (United States)

    1993-08-01

    J.L. and Day, S.M. Numerical Simulation of Quarry Blast Sources ............................ 263 McQuarrie , Allan D.R. and Shumway, Robert H...D.R. McQuarrie Robert H. Shumwav Division of Statistics University of California Davis, CA 95616 PHILLIPS LABORATORY Contract F19628-91-K-0033 1

  3. 77 FR 13352 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2012-03-06

    ... 202(b)(1); (B) an affirmative determination of market disruption or threat thereof under section 421(b...., Chicago, IL February 13, 2010. Corporate Resources, Aerotek, Dysis and Tek. 81,254 BT North America... Workforce Carolina. 81,263 Chartis Global Services, Houston, TX February 13, 2010. Inc., Regional...

  4. AcEST: DK961272 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ydroxylase OS=Agastache ... 263 7e-69 tr|Q0QDS3|Q0QDS3_9BORA Cinnamic acid 4-hydroxylase OS=Arnebia eu... 26...GIVLRRRLQLMM 182 >tr|Q0QDS3|Q0QDS3_9BORA Cinnamic acid 4-hydroxylase OS=Arnebia euchroma PE=2 SV=2 Length =

  5. Basic Forward Chaining Construction for Logic Programs

    Science.gov (United States)

    1997-06-01

    Remmel. Nonmonotonic rule systems I. Annals of Mathematics and Artificial Intelligence, 1:241-273, 1990. [MNR92c] W. Marek, A. Nerode, and J.B. Remmel...Nonmonotonic rule systems II. Annals of Mathematics and Artificial Intelligence, 5:229-263, 1992. [MNR92a] W. Marek, A. Nerode, and J. B. Remmel

  6. Optimal selection for BRCA1 and BRCA2 mutation testing using a combination of 'easy to apply' probability models.

    NARCIS (Netherlands)

    Bodmer, D.; Ligtenberg, M.J.L.; Hout, A.H. van der; Gloudemans, S.; Ansink, K.; Oosterwijk-Wakka, J.C.; Hoogerbrugge-van der Linden, N.

    2006-01-01

    To establish an efficient, reliable and easy to apply risk assessment tool to select families with breast and/or ovarian cancer patients for BRCA mutation testing, using available probability models. In a retrospective study of 263 families with breast and/or ovarian cancer patients, the utility of

  7. Optimal selection for BRCA1 and BRCA2 mutation testing using a combination of ' easy to apply ' probability models

    NARCIS (Netherlands)

    Bodmer, D.; Ligtenberg, M. J. L.; van der Hout, A. H.; Gloudemans, S.; Ansink, K.; Oosterwijk, J. C.; Hoogerbrugge, N.

    2006-01-01

    To establish an efficient, reliable and easy to apply risk assessment tool to select families with breast and/or ovarian cancer patients for BRCA mutation testing, using available probability models. In a retrospective study of 263 families with breast and/or ovarian cancer patients, the utility of

  8. 77 FR 29346 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-05-17

    ....S.C. Sec. 263)) and Section 7 of the International Banking Act (12 U.S.C. 3105(c)(2)) and is... small business lending, as well as a more comprehensive picture of differences in lending conditions at... topics of timely interest. The survey helps pinpoint developing trends in bank funding...

  9. Cortical-Cortical Interactions and Sensory Information Processing in Autism

    Science.gov (United States)

    2011-04-01

    Brumberg et al., 1996; Derdikman et al., 2003; Foeller et al., 2005; Wirth and Luscher , 2004). Similarly, imaging studies that have used the OIS have...Motor Research, 18: 263-285. Wirth, C. & Luscher , H.R. (2004). Spatiotemporal evolution of excitation and inhibition in the rat barrel cortex

  10. 5 CFR Appendix A to Part 581 - List of Agents Designated To Accept Legal Process

    Science.gov (United States)

    2010-01-01

    ... employee-obligors employed by the Census Data Preparation Division: Bureau of the Census, Data Preparation..., (206) 526-6057 10. In cases where the name of the operating unit cannot be determined: Director for... Simler Avenue, Big Spring, TX 79720, (915) 263-8304 Federal Correctional Institution, Personnel Office,...

  11. Lewis, Peirce F., 2003: New Orleans: The Making of an Urban Landscape [Reseña bibliográfica

    OpenAIRE

    Cebrián, Juan A.

    2007-01-01

    Es reseña de : Lewis, Peirce F., 2003: New Orleans: The Making of an Urban Landscape, second edition, Santa Fe, New Mexico, Center for American PLACES Inc. in association with the University of Virginia Press, 200 pp.” En Estudios Geográficos, LXVIII, 263, pp. 737-739.

  12. QTL Information Table: 703 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available SR C)Interval RIL Lemont Teqing A RM263 RM221 pha Huang, Z., Yu, T., Su, L., Yu, S.B., Zhang, Z.H., and Zhu, Y.G. (2004). Identificat...ion of chromosome regions associated with seedling vigor in rice. Yi Chuan Xue Bao 31, 596-603. ...

  13. Mindset Change Prerequisite for Academic Excellence: A Case of Four Zimbabwean and South African Universities

    Science.gov (United States)

    Makondo, L.

    2012-01-01

    This article submits that the calibre, attitude and mindset of lecturers/teachers in institutions of Higher Education need drastic improvement and change if academic excellence is to be attainable and sustained in the 21st century. This article builds on the observations by Makondo (2010, 263-276) that most university teaching staff members are…

  14. Which is your favorite hotel lobby in China?

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> We ve set aside this page for our readers to write about their favorite hotel lobby in China. Please fell free to fax your ideas to us at 010-63982126 or email them via apple_chenyu@263.net . The author of the most interesting

  15. Fine Mapping and Evolution of a QTL Region on Cattle Chromosome 3

    Science.gov (United States)

    Donthu, Ravikiran

    2009-01-01

    The goal of my dissertation was to fine map the milk yield and composition quantitative trait loci (QTL) mapped to cattle chromosome 3 (BTA3) by Heyen et al. (1999) and to identify candidate genes affecting these traits. To accomplish this, the region between "BL41" and "TGLA263" was mapped to the cattle genome sequence assembly Btau 3.1 and a…

  16. AcEST: BP912829 [AcEST

    Lifescience Database Archive (English)

    Full Text Available n transcription factor ... 31 4.5 sp|O02751|CFDP2_BOVIN Craniofacial development protein 2 OS=Bos ... 31 4.5...Sbjct: 246 IHLVNMYFNWHYPYFTTL 263 >sp|O02751|CFDP2_BOVIN Craniofacial development protein 2 OS=Bos taurus GN

  17. Drug: D10089 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10089 Drug Amitifadine hydrochloride (USAN) C11H11Cl2N. HCl 263.0035 264.5787 D10089.gif Treatment of depre...ssion serotonin transporter inhibitor [HSA:6532] [KO:K05037]; noradrenalin transpor

  18. Identification and Management of Multiple Threats to Rare and Endangered Plant Species

    Science.gov (United States)

    2013-07-30

    Earthworm effects were 2.63E-05 (not shown). 3.8.3. Carex retroflexa Carex retroflexa is an evergreen sedge and therefore, we used a seasonal matrix...plants, earthworms and a root-weevil on demography of rare understory species (Aristolochia serpentaria, Agrimonia rostellata, Carex retroflexa, and...serpentaria ....................................................................................................... 80 3.6.3. Carex retroflexa

  19. Educators vs. Entrepreneurs: Traits and Bias in the Teaching of SWOT

    Science.gov (United States)

    Clark, Andre

    2011-01-01

    A study of the marks allocated by 10 tutors to 263 students' SWOT (Strengths, Weaknesses, Opportunities, Threats) analyses on a range of business education courses reveals a largely hidden assumption regarding the balance of the four factors. To investigate the significance of this in light of the suggestion in the trait literature that…

  20. Proteomic Prediction of Breast Cancer Risk: A Cohort Study

    Science.gov (United States)

    2009-03-01

    P59910) Testis spermatocyte apoptosis-related gene 6 protein (Testis and spermatogenesis cell rela 263 (Q9HCK0) Zinc finger and BTB domain containing...NY-REN 447 (Q9P0W8) Spermatogenesis associated protein 7 ( Spermatogenesis associated protein HSD3) (HSD-3.1) 448 (P51991) Heterogeneous nuclear

  1. Champagne for the cryogenics teams

    CERN Multimedia

    2005-01-01

    Christmas has come early for the LHC as a complete sector of the cryogenic distribution line has been operating at 10 degrees Kelvin (-263°C) for the past two weeks, just a few degrees above the machine's nominal operating temperature.

  2. Somali Syntax,

    Science.gov (United States)

    1979-01-01

    self - here - flowed - blood hissing or gushing sound (The blood spurted out like a fountain.) (263) arrived -- yesterday Shaley buu y-imi...Ways of Expressing the Meanings Associated with the Degree to Which One Possesses a Quality An overview of these devices is given below in Figure 9

  3. Developmental Dynamics of Emotion and Cognition Processes in Preschoolers

    Science.gov (United States)

    Blankson, A. Nayena; O'Brien, Marion; Leerkes, Esther M.; Marcovitch, Stuart; Calkins, Susan D.; Weaver, Jennifer Miner

    2013-01-01

    Dynamic relations during the preschool years across processes of control and understanding in the domains of emotion and cognition were examined. Participants were 263 children (42% non-White) and their mothers who were seen first when the children were 3 years old and again when they were 4. Results indicated dynamic dependence among the…

  4. Preschool Classroom Processes as Predictors of Children's Cognitive Self-Regulation Skills Development

    Science.gov (United States)

    Fuhs, Mary Wagner; Farran, Dale C.; Nesbitt, Kimberly Turner

    2013-01-01

    This research focuses on the associations between interactive processes of early childhood classrooms and gains in children's cognitive self-regulation (CSR) across the preschool year. Data from 803 children (45.8% female; "M" = 54 months; 39.1% Caucasian, 26.3% African American, 24.6% Hispanic, 9.9% Other) were collected at fall and…

  5. Context effect in assimilation and contrast

    NARCIS (Netherlands)

    Weert, C.M.M. de; Koning, A.R.; Lier, R.J. van

    2005-01-01

    We have systematically studied the change of lightness appearance in an ambiguous visual pattern. Fuchs (1923 Zeitschrift für Psychologie 92 249 - 325) found that differently coloured parts assimilate, whereas Agostini et al (1993 Perception 22 263 - 272) described the opposite effect: contrast betw

  6. Spontaneous Focusing on Quantitative Relations as a Predictor of the Development of Rational Number Conceptual Knowledge

    Science.gov (United States)

    McMullen, Jake; Hannula-Sormunen, Minna M.; Laakkonen, Eero; Lehtinen, Erno

    2016-01-01

    Many people have serious difficulties in understanding rational numbers, limiting their ability to interpret and make use of them in modern daily life. This also leads to later difficulties in learning more advanced mathematical content. In this study, novel tasks are used to measure 263 late primary school students' spontaneous focusing on…

  7. Data of evolutionary structure change: 1OZHB-1UPCB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHB-1UPCB 1OZH 1UPC B B VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL... PRO CA 363 ALA CA 263 MET CA 338 1UPC... B 1UPCB YDYAEDLRPSMLEU CA 420 VAL CA 465 HIS CA 477 1UPC... B 1UPCB

  8. Data of evolutionary structure change: 1OZHB-1UPCA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHB-1UPCA 1OZH 1UPC B A VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...ine> PRO CA 363 ALA CA 263 MET CA 338 1UPC... A 1UPCA YDYAEDLRPSMLEU CA 420 VAL CA 465 HIS CA 477 1UPC... A 1UPCA

  9. Data of evolutionary structure change: 1OZFB-1UPCF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZFB-1UPCF 1OZF 1UPC B F YPVRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDS... 263 ASP CA 266 1UPC F 1UPC... 1UPC F 1UPCF MET CA 302 1UPC F 1UPC...CA 345 LEU CA 430 VAL CA 464 HIS CA 467 1UPC

  10. Data of evolutionary structure change: 1OZHB-1UPCF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHB-1UPCF 1OZH 1UPC B F VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...A 363 ALA CA 263 MET CA 338 1UPC F 1UPCF YDYAEDLRPSM LEU CA 420 VAL CA 465 HIS CA 477 1UPC... F 1UPCF

  11. Data of evolutionary structure change: 1OZHB-1UPCE [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHB-1UPCE 1OZH 1UPC B E VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL...344 PRO CA 363 ALA CA 263 MET CA 338 1UPC... E 1UPCE YDYAEDLRPSM...D> 9 1UPC E 1UPCELEU CA 420 VAL CA 465 HIS CA 477 1UPC

  12. Data of evolutionary structure change: 1OZHB-1UPCD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1OZHB-1UPCD 1OZH 1UPC B D VRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLL.../line> PRO CA 363 ALA CA 263 MET CA 338 1UPC... D 1UPCD YDYAEDLRPSM LEU CA 420 VAL CA 465 HIS CA 477 1UPC... D 1UPCD

  13. 26 CFR 1.45G-1 - Railroad track maintenance credit.

    Science.gov (United States)

    2010-04-01

    ... tangible asset or as an intangible asset. See, for example, § 1.263(a)-4(d)(8), which requires... taxpayer. The basis of the tangible asset or intangible asset includes the capitalized amount of the QRTME... to be capitalized into the qualifying railroad structure or an intangible asset. The adjusted...

  14. The behaviour of aluminium in waters of the Mandovi estuary, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Upadhyay, S.; SenGupta, R.

    , R.S. Gupta/Marine Chemistry51 (1995) 261-276 263 be classified as a tide-dominated coastal plain estu- ary and geomorphologically as a drowned river val- ley formed during the Holocene sea-level rise (Murty et al., 1976). A large part...

  15. The Effect of Unsteady Wakes on Turbine Tip Gap Leakage

    Science.gov (United States)

    2013-05-10

    Turbine 5 Figure 2: The gas turbine thermodynamic system - Cengel and Boles (2002). Figure 3: Turbine blades on a rotor – European...1989. “The measurement and formation of tip clearance loss,” ASME Journal of Turbomachinery, Vol.111, pp. 257–263. Cengel , Y. A. and Boles, M.A

  16. Recommendations Concerning Methods and Media Appropriate to Leadership Training and Education at the US Coast Guard Academy.

    Science.gov (United States)

    1973-05-01

    Four-Factor Tehory of Leadership," Administrative Science Quarterly, 1966, 11, 238-263. Herzberg , Frederick . "The Motivation to Work Among Finnish...conditions of subordinates. They reflect the Herzberg A-9 (1965) hygiene factors, and the conventional military category of "welfare of subordinates

  17. AcEST: BP919962 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TWI2_PHYPA Predicted protein OS=Physcomitrella paten... 46 5e-09 tr|A9TZP1|A9TZP1_PHYPA Glucose-1-phosphate ... = 18/19 (94%) Frame = -2 Query: 58 SDADITISCVPIDDSRASD 2 S ADITISCVP+DDSRASD Sbjct: 245 SGADITISCVPMDDSRASD 263 >tr|A9TZP1|A9TZP

  18. 7 CFR 1822.264 - Eligibility requirements.

    Science.gov (United States)

    2010-01-01

    ... GRANTS PRIMARILY FOR REAL ESTATE PURPOSES RURAL HOUSING LOANS AND GRANTS Rural Housing Site Loan Policies... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... § 1822.263 (a) or (b) which is authorized to provide housing sites on a nonprofit basis. (1) If it is...

  19. 75 FR 35335 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Gulf of Mexico Reef Fish Fishery...

    Science.gov (United States)

    2010-06-22

    ... from Rich Malinowski, NMFS, Southeast Regional Office, 263 13th Avenue South, St. Petersburg, FL 33701; telephone: 727-824-5305. FOR FURTHER INFORMATION CONTACT: Rich Malinowski, telephone: 727-824- 5305, e-mail Rich.Malinowski@noaa.gov . SUPPLEMENTARY INFORMATION: The reef fish fishery of the Gulf is...

  20. 77 FR 39460 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Science.gov (United States)

    2012-07-03

    ... ``Instructions'' for submitting comments. Mail: Rich Malinowski, Southeast Regional Office, NMFS, 263 13th Avenue....gov . FOR FURTHER INFORMATION CONTACT: Rich Malinowski, Southeast Regional Office, NMFS, telephone 727-824-5305; email: rich.malinowski@noaa.gov . SUPPLEMENTARY INFORMATION: The Reef fish fishery of...

  1. 78 FR 14225 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Gulf of Mexico Reef Fish Fishery...

    Science.gov (United States)

    2013-03-05

    ... Malinowski, NMFS, Southeast Regional Office, 263 13th Avenue South, St. Petersburg, FL 33701; telephone: 727-824-5305. FOR FURTHER INFORMATION CONTACT: Rich Malinowski, telephone: 727-824- 5305, or email: Rich.Malinowski@noaa.gov . SUPPLEMENTARY INFORMATION: The reef fish fishery of the Gulf is managed under...

  2. 77 FR 31586 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Science.gov (United States)

    2012-05-29

    ... document identifier: ``FL Sea Grant EFP''. Mail: Rich Malinowski, Southeast Regional Office, NMFS, 263 13th... upon written request to any of the above addresses. FOR FURTHER INFORMATION CONTACT: Rich Malinowski, 727-824-5305; email: rich.malinowski@noaa.gov . SUPPLEMENTARY INFORMATION: The EFP is requested...

  3. Engineered Approaches to In Situ Bioremediation of Chlorinated Solvents: Fundamentals and Field Applications

    Science.gov (United States)

    2000-07-01

    Mark Kemper and Philip Cluxton, Cluxton Instruments, Inc., Martinsville, Ohio Souhail Al- Abed and William Slack, FRX, Inc., Cincinnati, Ohio 263 * These...biodegraded via cometabolism or by direct aerobic bioprocesses ). The lab studies also successfully predicted the need for a significant time period (weeks

  4. THE DETERMINANT REPRESENTATION OF THE GAUGE TRANSFORMATION OPERATORS

    Institute of Scientific and Technical Information of China (English)

    贺劲松; 李翊神; 程艺

    2002-01-01

    The determinant representation of the gauge transformation operators is establised. In this process, the generalized Wronskian determinant is introduced. As a simple application, the auMath. Phys., 149(1992), 263), which involves the generalized Wronskian determinant. Also,some properties of this determinant are given.

  5. AcEST: DK956530 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TH Cysteine proteinase RD21a OS=Arabidopsis t... 195 2e-49 sp|Q94B08|GCP1_ARATH Germination...V YSE +L +AV Sbjct: 238 KNAKVVTIDSYEDVPTYSEESLKKAV 263 >sp|Q94B08|GCP1_ARATH Germination-specific cysteine p

  6. Analysis of the DNDI gene in men with sporadic and familial testicular germ cell tumors

    NARCIS (Netherlands)

    Linger, Rachel; Dudakia, Darshna; Huddart, Robert; Tucker, Kathy; Friedlander, Michael; Phillips, Kelly-Anne; Hogg, David; Jewett, Michael A. S.; Lohynska, Radka; Daugaard, Gedske; Richard, Stephane; Chompret, Agnes; Stoppa-Lyonnet, Dominique; Bonaiti-Pellie, Catherine; Heidenreich, Axel; Albers, Peter; Olah, Edith; Geczi, Lajos; Bodrogi, Istvan; Daly, Peter A.; Guilford, Parry; Fossi, Sophie D.; Heimdal, Ketil; Tjulandin, Sergei A.; Liubchenko, Ludmila; Stoll, Hans; Weber, Walter; Einhorn, Lawrence; McMaster, Mary; Korde, Larissa; Greene, Mark H.; Nathanson, Katherine L.; Cortessis, Victoria; Easton, Douglas F.; Bishop, D. Timothy; Stratton, Michael R.; Rapley, Elizabeth A.

    2008-01-01

    A base substitution in the mouse DndI gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a famil

  7. Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7)

    DEFF Research Database (Denmark)

    Oza, Amit M; Cook, Adrian D; Pfisterer, Jacobus

    2015-01-01

    of the trial. METHODS: ICON7 was an international, phase 3, open-label, randomised trial undertaken at 263 centres in 11 countries across Europe, Canada, Australia and New Zealand. Eligible adult women with newly diagnosed ovarian cancer that was either high-risk early-stage disease (International Federation...

  8. Midway Atoll Site P18 12/4/2002 1-2M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Midway Atoll, site P18 (28.263 N, 177.337 W), between 1 and 2 meters along a permanent transect.

  9. Notification

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    China Today’s now e-mall addresses for each editionare now in operation!So write! Share your views and comments with us,and with fellow subscribers.Dear Readers,Our email address, chinatoday@263.net, is defunct. We now have separateaddresses for each of our editions. They are:

  10. 40 CFR 266.101 - Management prior to burning.

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT FACILITIES Hazardous Waste Burned in Boilers and Industrial Furnaces § 266.101 Management prior to burning. (a) Generators. Generators of hazardous waste that is burned in a boiler or industrial furnace... burned in a boiler or industrial furnace are subject to part 263 of this chapter. (c) Storage...

  11. 77 FR 32183 - Transmission Planning and Cost Allocation by Transmission Owning and Operating Public Utilities

    Science.gov (United States)

    2012-05-31

    ... to Consideration of 195 Transmission Needs Driven by Public Policy Requirements i. Requests for... Clarification..... 235 c. Commission Determination 263 3. Consideration of Transmission Needs Driven by 302... Commission Did Not Show 551 That Existing Rates Are Unjust and Unreasonable 3. Commission Determination 555...

  12. 76 FR 28192 - [NRC-2009-0482

    Science.gov (United States)

    2011-05-16

    ... in a petition for rulemaking (PRM) submitted by Robert Meyer, on behalf of the Professional Reactor... published Notice of Receipt of a PRM filed by Robert Meyer, on behalf of the PROS, and request for public... determined that the issues raised in PRM-26-3 are appropriate for consideration and will consider them in...

  13. Data of evolutionary structure change: 1G9OA-2VPHB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1G9OA-2VPHB 1G9O 2VPH A B RMLPRLCCLEKGPNGYGFHLHGEKGKL-GQYIRLVEPGS...LN CA 361 TYR CA 377 ILE CA 380 ARG CA 263 2VPH B 2VPHB GYDQK...line>GLY CA 300 2VPH B 2VPHB PADLCVPRLNEG

  14. 75 FR 80746 - Interpretation of Rest Requirements

    Science.gov (United States)

    2010-12-23

    ... Federal Aviation Administration 14 CFR Part 135 Interpretation of Rest Requirements AGENCY: Federal... proposes to interpret the application of 14 CFR 135.263 and the rest requirements of Sec. 135.267(d) to... they will not receive the 10 hours of rest required in a 24-hour period by section...

  15. Review of Part 67 Of the Federal Air Regulations and the Medical Certification of Civilian Airmen. Volume 2

    Science.gov (United States)

    1983-01-01

    Myocardial Disease .................................. 242 Pericardial Disease .................................. 25( Valvular Heart Disease ............................... 263...ischemic heart disease, hypertension, valvular heart disease , congenital heart disease, myocardial-pericardial disease, peripheral va3cular disease and...cardiovascular evaluation for pilots with valvular heart disease should include at a minimum echocardiogra•hy, continuous ECG monitoring and treadmill stress

  16. Improved Acquisition for System Sustainment: Availability-Based Importance Framework for Maintenance, Repair, and Overhaul Acquisition

    Science.gov (United States)

    2015-06-30

    reference-dependent theory, wherein consumers evaluate alternatives in terms of gains and losses to a subjective reference point [ Kahneman and Tversky 1979...Verlag. Kahneman , D. and A. Tversky. 1979. Prospect Theory: An Analysis of Decision under Risk. Econometrica, 47(2): 263-291. Kasirian, M. and R

  17. 41 CFR 101-26.301-2 - Issue of used, repaired, and rehabilitated items in serviceable condition.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Issue of used, repaired... and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.3-Procurement of GSA Stock...

  18. Understanding the degree of awareness among medical professionals regarding the ethics of pharmaceutical marketing activities in context of revised medical council of India code of ethics

    Directory of Open Access Journals (Sweden)

    Renuka H. Munshi

    2016-04-01

    Conclusions: Most physicians do maintain a code of ethics with regards to accepting gifts and they felt that inexpensive gifts do not influence clinical judgment. Consultants were of the view that amended MCI code of ethics would not affect their clinical practice significantly. [Int J Basic Clin Pharmacol 2016; 5(2.000: 263-268

  19. FY 2002 Quarterly Report Reporting Period Ending September 30, 2002 Grant No. DE-FG03-01SF22335

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-09-30

    A consensus-based collaborative formed in 1994, the National Wind Coordinating Committee (NWCC) is comprised of representatives from utility, wind, environmental, consumer, regulatory, power marketer, agricultural, tribal, economic development, State and federal government sectors interested in encouraging the prudent acceleration of wind power deployment in the United States. B263

  20. 21 CFR 316.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... Service Act (42 U.S.C. 262-263). (9) Marketing application means an application for approval of a new drug... approval letter of a marketing application for a sponsor of a designated orphan drug, no approval will be... with similar therapeutic intent, such as two live viral vaccines for the same indication, would...

  1. Miguel Prieto Anguita

    OpenAIRE

    Cabañas Bravo, Miguel

    2013-01-01

    Miguel Cabañas Bravo: "Miguel Prieto Anguita". En: Gonzalo Anes (dir.): Diccionario Biográfico Español, tomo XLII; Madrid, Real Academia de la Historia, 2013, pp. 260-263 (ISBN: 978-84-96849-56-3 O.C., 978-84-15069-04-1 vol. XLII)

  2. Variation in Second Language Learners' Strategies among Non-Native English Speakers from Three Language/Culture Backgrounds

    Science.gov (United States)

    Ebsworth, Miriam Eisenstein; Tang, Frank Lixing; Razavi, Nikta; Aiello, Jacqueline

    2014-01-01

    This study explored the effects of cultural and linguistic background, L2 proficiency, and gender on language learning strategies for 263 college-level learners from Chinese, Russian, and Latino backgrounds. Data based on the SILL (Oxford, 2001) revealed that Russian students used significantly more strategies than the Chinese students in three…

  3. EST Table: FY756927 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to Protein SDA1 homolog (Mystery protein 45A) [Tribolium castaneum] gb|EFA00563.1| hypothetical protein T... 50 %/181 aa gnl|Amel|GB18390-PA 11/11/04 44 %/263 aa gi|91078808|ref|XP_970433.1| PREDICTED: similar to Protein SDA1 homolog (Myster

  4. Self-Regulation in Early Adolescence: Relations with Mother-Son Relationship Quality and Maternal Regulatory Support and Antagonism

    Science.gov (United States)

    Moilanen, Kristin L.; Shaw, Daniel S.; Fitzpatrick, Amber

    2010-01-01

    The purpose of the current investigation was to examine relations among maternal regulatory support, maternal antagonism, and mother-son relationship quality in relation to boys' self-regulation during early adolescence. As part of a larger longitudinal study on 263 low-income, ethnically diverse boys, multiple informants and methods were used to…

  5. Interframe hierarchical vector quantization using hashing-based reorganized codebook

    Science.gov (United States)

    Choo, Chang Y.; Cheng, Che H.; Nasrabadi, Nasser M.

    1995-12-01

    Real-time multimedia communication over PSTN (Public Switched Telephone Network) or wireless channel requires video signals to be encoded at the bit rate well below 64 kbits/second. Most of the current works on such very low bit rate video coding are based on H.261 or H.263 scheme. The H.263 encoding scheme, for example, consists mainly of motion estimation and compensation, discrete cosine transform, and run and variable/fixed length coding. Vector quantization (VQ) is an efficient and alternative scheme for coding at very low bit rate. One such VQ code applied to video coding is interframe hierarchical vector quantization (IHVQ). One problem of IHVQ, and VQ in general, is the computational complexity due to codebook search. A number of techniques have been proposed to reduce the search time which include tree-structured VQ, finite-state VQ, cache VQ, and hashing based codebook reorganization. In this paper, we present an IHVQ code with a hashing based scheme to reorganize the codebook so that codebook search time, and thus encoding time, can be significantly reduced. We applied the algorithm to the same test environment as in H.263 and evaluated coding performance. It turned out that the performance of the proposed scheme is significantly better than that of IHVQ without hashed codebook. Also, the performance of the proposed scheme was comparable to and often better than that of the H.263, due mainly to hashing based reorganized codebook.

  6. Data of evolutionary structure change: 1E4WL-1MCEA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E4WL-1MCEA 1E4W 1MCE L A DIQMTQTPSSLSASLGDRVTISCRASQ---DISHYLNWF...DINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC- PSALTQ-PPSASGSLGQSVTI...ain>A 1MCEA CSSYEGSDNFV EE...263 ALA CA 289 1MCE A 1MCEA...in>A 1MCEA SKQSN-NKYAA -

  7. AcEST: DK962770 [AcEST

    Lifescience Database Archive (English)

    Full Text Available pG 1 OS=Rickettsia ... 32 3.5 sp|Q11KP9|KATG_MESSB Catalase-peroxidase OS=Mesorhizobium sp. (s... 31 4.6 sp|...LGG ++ Sbjct: 263 ASVGKFWGVMGAIVGGLLGGFIM 285 >sp|Q11KP9|KATG_MESSB Catalase-peroxidase OS=Mesorhizobium sp.

  8. Anxious Attachment Style and Salivary Cortisol Dysregulation in Healthy Female Children and Adolescents

    Science.gov (United States)

    Oskis, Andrea; Loveday, Catherine; Hucklebridge, Frank; Thorn, Lisa; Clow, Angela

    2011-01-01

    Background: Attachment style has been linked with basal cortisol secretion in healthy adult women. We investigated whether dysregulation in basal cortisol secretion may be evident in younger healthy females. Methods: Sixty healthy females aged 9-18 years (mean 14.16, SD [plus or minus] 2.63 years) participated in the Attachment Style Interview…

  9. Leukocyte count affects expression of reference genes in canine whole blood samples

    NARCIS (Netherlands)

    Piek, C.J.; Brinkhof, B.; Rothuizen, J.; Dekker, A.; Penning, L.C.

    2011-01-01

    Background The dog is frequently used as a model for hematologic human diseases. In this study the suitability of nine potential reference genes for quantitative RT-PCR studies in canine whole blood was investigated. Findings The expression of these genes was measured in whole blood samples of 263 i

  10. Command and Control of the U.S. Tenth Army During the Battle of Okinawa

    Science.gov (United States)

    2009-06-12

    30 Appleman, et al, 498. 31 Nichols and Shaw, 271. 32 Ibid., 261. 33 Ibid., 263. 34 Craig M. Cameron, American Samurai : Myth, Imagination...Annapolis: Naval Institute Press, 1987. Cameron, Craig M. American Samurai : Myth, Imagination, and the Conduct of Battle of the First Marine

  11. The Effectiveness of a Peer-Led HIV/AIDS and STI Health Education Intervention for Prison Inmates in South Africa

    Science.gov (United States)

    Sifunda, Sibusiso; Reddy, Priscilla S.; Braithwaite, Ronald; Stephens, Torrence; Bhengu, Sibusisiwe; Ruiter, Rob A. C.; van den Borne, Bart

    2008-01-01

    This article reports on the effectiveness of the first systematically developed health education intervention for the reduction of risky sexual behavior among soon-to-be-released prisoners in South Africa. Data from three out of four prisons are eligible for data analysis including 263 inmates. Using a nested experimental design, short-term…

  12. 47 CFR 90.531 - Band plan.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Regulations Governing the Licensing and Use of Frequencies in the 763-775 and 793..., 159, 160, 183, 184, 199, 200, 223, 224, 239, 240, 263, 264, 279, 280, 303, 304, 319, 320, 641,...

  13. Participation in Occupational Performance: Reliability and Validity of the Activity Card Sort.

    Science.gov (United States)

    Katz, Noomi; Karpin, Hanah; Lak, Arit; Furman, Tania; Hartman-Maeir, Adina

    2003-01-01

    A study assessed the reliability and validity of the Activity Card Sort (ACS) within different adult groups (n=263): healthy adults, healthy older adults, Alzheimer's caregivers, multiple sclerosis patients, and stroke survivors. Found that the ACS had high internal consistency for daily living and social-cultural activities and a lower…

  14. Drug: D06203 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06203 Drug Transcainide (USAN/INN) C22H35N3O2 373.2729 373.5322 D06203.gif Cardiac depressant [anti-arrhyth...mic] CAS: 88296-62-2 PubChem: 47207861 LigandBox: D06203 NIKKAJI: J263.287J ATOM 27

  15. Epilepsy

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009243 Multicenter randomized,double-blind,placebo-controlled trial of zonisamide as add-on therapy in patients with refractor partial seizures.YU Peimin(虞培敏),et al.Dept Neurol,Huashan Hosp,Fudan Univ,Shanghai 200040.Chin J Neurol,2009;4294):263-267.

  16. Exploring the Local Milky Way: M Dwarfs as Tracers of Galactic Populations

    Science.gov (United States)

    2007-12-01

    determinations of M dwarfs are difficult (Woolf & Wallerstein 2006), proxies of metallicity have been employed (Gizis 1997; Lépine et al. 2003; Burgasser...128, 426 Wielen, R. 1977, A&A, 60, 263 Wilson, O., & Woolley, R. 1970, MNRAS, 148, 463 Woolf, V. M., & Wallerstein , G. 2006, PASP, 118, 218 Yanny, B

  17. 3-D Imaging Using Row-Column-Addressed Arrays With Integrated Apodization

    DEFF Research Database (Denmark)

    Christiansen, Thomas Lehrmann; Rasmussen, Morten Fischer; Bagge, Jan Peter;

    2015-01-01

    This paper demonstrates the fabrication, characterization, and experimental imaging results of a 62+62 element λ/2-pitch row-column-addressed capacitive micromachined ultrasonic transducer (CMUT) array with integrated apodization. A new fabrication process was used to manufacture a 26.3 mm by 26...

  18. A Century of Change: The Evolution of School Library Resources, 1915-2015

    Science.gov (United States)

    Lamb, Annette

    2015-01-01

    School libraries have been in existence since at least the eighth century. However, it wasn't until the twentieth century that the school library was seen primarily as "a source of enrichment for the curriculum, and a means of developing reading and study habits in the pupils" (Clyde 1981, 263). While the formats available and tools for…

  19. High-Quality Draft Genome Sequence of Kallotenue papyrolyticum JKG1T Reveals Broad Heterotrophic Capacity Focused on Carbohydrate and Amino Acid Metabolism.

    Science.gov (United States)

    Hedlund, Brian P; Murugapiran, Senthil K; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T B K; Ngan, Chew Yee; Daum, Chris; Duffy, Kecia; Shapiro, Nicole; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Williams, Amanda J; Cole, Jessica K; Dodsworth, Jeremy A; Woyke, Tanja

    2015-12-03

    The draft genome of Kallotenue papyrolyticum JKG1(T), a member of the order Kallotenuales, class Chloroflexia, consists of 4,475,263 bp in 4 contigs and encodes 4,010 predicted genes, 49 tRNA-encoding genes, and 3 rRNA operons. The genome is consistent with a heterotrophic lifestyle including catabolism of polysaccharides and amino acids.

  20. Effects of the content and language integrated learning approach to EFL teaching: A comparative study

    NARCIS (Netherlands)

    Goris, J.A.; Denessen, E.J.P.G.; Verhoeven, L.T.W.

    2013-01-01

    This study investigates the effects of English-medium CLIL on EFL proficiency in three European countries. Seven mainstream grammar schools spread across The Netherlands, Germany, and Italy participated with a total of 263 pupils aged 12 to 16. Several language skills were measured by means of writt

  1. The United States Air Force Academy’s First Twenty-Five Years, Some Perceptions.

    Science.gov (United States)

    1979-01-01

    263 (Introduction to Life Science), Life Sci 431-432 ( Microbiology I & II), and Life Sci 461-462 (Developmental Anatomy I & II). II Lt Col John R...The Ecuador -Peru Dispute; and (with Robin Higham) A Short History of Warfare. .-. ? 170 Dean of the Faculty sponsored by the National Archives to

  2. Domain Modeling: NP_066574.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_066574.2 chr2 CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA c1meyf_ chr2/NP_066574....2/NP_066574.2_holo_254-335.pdb blast 255K,259C,261E,262C,263G,264K,265A,266F,267F,268D

  3. AcEST: DK947711 [AcEST

    Lifescience Database Archive (English)

    Full Text Available on-ATPase regulat... 39 0.008 sp|P03331|GAG_FRSF5 Gag polyprotein OS=Friend spleen focus-formi... 32 1.3 sp|...LERIV 263 >sp|P03331|GAG_FRSF5 Gag polyprotein OS=Friend spleen focus-forming virus (isolate 502) GN=gag PE=

  4. QTL Information Table: 586 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSS-2 Physiological trait Sterility spikelet fertility SSR C)Interval F2 CPSLO17 W2...07-2 A RM301 RM263 pha Wang, C., Zhu, C., Zhai, H., and Wan, J. (2005). Mapping segregation distortion loci and quantitative trait

  5. Domain Modeling: NP_057507.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_057507.2 chr14 Aart, a six finger zinc finger designed to recognize ANN triplets... c2i13b_ chr14/NP_057507.2/NP_057507.2_holo_27-178.pdb psi-blast 254R,256A,257T,258P,259T,260P,263A,265P,276

  6. La dimensión humana de la formación sacerdotal. Aproximación histórica, aspectos canónicos y estrategias formativas. [Reseña

    OpenAIRE

    Pellitero, R.

    2003-01-01

    Reseña de José SAN JOSË PRISCO, La dimensión humana de la formación sacerdotal. Aproximación histórica, aspectos canónicos y estrategias formativas, Universidad Pontificia de Salamanca, Salamanca 2002, 263pp., 17*23,ISBN 84-7299-525-9

  7. Setting the Theater: US Sustainment Operations in the Pacific during World War II

    Science.gov (United States)

    2016-05-26

    57 Eccles, Logistics in the National Defense, 32. 58 Leighton and Coakley, Global Logistics and Strategy , 179. 59 Ibid...60 Leighton and Coakley, Global Logistics and Strategy , 182. 61 James R. Masterson, US Army Transportation in...Transportation Corps (Fort Eustis, VA: US Army Transportation Center, 1994), 263. 77 Leighton and Coakley, Global Logistics and Strategy , 391. 78

  8. pi-dimerization of pleiadiene radical cations at low temperatures revealed by UV-vis spectroelectrochemistry and quantum theory

    NARCIS (Netherlands)

    van het Goor, Layo; van Duijnen, Piet Th.; Koper, Carola; Jenneskens, Leonardus W.; Havenith, Remco W. A.; Hartl, Frantisek

    2011-01-01

    One-electron oxidation of the non-alternant polycyclic aromatic hydrocarbon pleiadiene and related cyclohepta[c,d]pyrene and cyclohepta[c,d]fluoranthene in THF produces corresponding radical cations detectable in the temperature range of 293-263 K only on the subsecond time scale of cyclic voltammet

  9. EST Table: FS765182 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available arbonic anhydrase [Bombyx mori] gb|ABD36210.1| erythrocyte carbonic anhydrase [Bombyx mori] 10/09/08 57 %/263 aa FBpp0080116|CAH...1-PA 10/08/28 33 %/219 aa R01E6.3a#CE29433#WBGene00000282#locus:cah-4#carbonic anhydrase

  10. Prevalence of Demodex spp among alcohol-dependent patients

    Directory of Open Access Journals (Sweden)

    Mehmet Hanifi Kokacya

    2016-06-01

    Conclusion: Demodex spp. are more common in alcohol-dependent patients due conditions of reduced self-care and immunosuppression. Demodex parasites should be considered in alcohol-dependent patients with skin lesions, especially on the face, and should to be treated if needed. [Cukurova Med J 2016; 41(2.000: 259-263

  11. Dissemination and implementation of "Aging Well and Healthily": A health-education and exercise program for older adults

    NARCIS (Netherlands)

    Westhoff, M.H.; Hopman-Rock, M.

    2002-01-01

    The article describes the dissemination and implementation of the Aging Well and Healthily (AWH) program in the Netherlands. In the period 1997-1999 this process was monitored by means of telephone interviews with 263 participants, 28 peer educators, and 13 organizers. The program participants were

  12. Ideal Police Oversight and Review: The Next Piece of the Community Policing Puzzle

    Science.gov (United States)

    2015-12-01

    Massachusetts MD Maryland MI Michigan NACOLE National Association for Civilian Oversight of Law Enforcement NC North Carolina NPMSRP National Police...National Association for Civilian Oversight of Law Enforcement.” 28 Perez, Common Sense about Police Review , 262–263. 9 Benjamin Jones of the Los...67 Alan Hunt, request for information response, Greensboro, North Carolina , Complaint Review Committee, April 27, 2015

  13. Advanced Technologies in Safe and Efficient Operating Rooms

    Science.gov (United States)

    2009-10-01

    such as robotic surgery and Natural Orifice Translumenal Endoscopic Surgery (NOTES). Such expansion, while both notable and necessary, should not...Nguan, C., Girvan, A., & Luke, P.P. (2008). Robotic surgery versus laparoscopy: A comparison between two robotic systems and laparoscopy...Journal of Robotic Surgery , 1, 263-268. Rasmussen, J. (1986). Information processing and human- machine interaction: An approach to cognitive

  14. Human Resource Models: An Overview.

    Science.gov (United States)

    1982-11-01

    AD A077 834 Problems," 18 pp., Dec 1978, AD A063 761 PP 261 PP 244 ille, Carlos L.; ZvlJac, David J. and Ross, John, "Franck- Sherman, Allan and...A077 835 * foroence Testing)." 403 pp., Jun 1979, AD A075 226 PP 263 PP 246 Robinson, Kathy I., "Using Commercial Taiers and Container- Brechling, Frenk

  15. Introduction of Women into Titan II Missile Operations.

    Science.gov (United States)

    1981-03-01

    areas (weapons system orientation: mnaintenance management. electronics principles , and technical publications. facility systems and missile Sfstents...Management. Electronics Principles . Technical Publications 97.00 2.63 94.04 5.27 2.31 Facility Systems 92.25 4.61 93.2) 5.80 -.62 Missile Systems 96.67 2.90

  16. The Rupture Test Characteristics of Six Precision-Cast and Three Wrought Alloys at 1700 and 1800 deg F

    Science.gov (United States)

    1945-11-01

    IIIm- III ImImIa— ?%. 38 loox (a) OriginalMicrostructure. I’JACA ARR No. ., Aqu~ Regla in Glycerineetch - Vickershardness201. Fracture- lOOX [b) 516...ruptureat 1700° Funder 7000 psi. Aqua Regla in GlycePlneetch - Vickershardnesa263. FIGURE41.- MICROSTRUCTURESOF WROOGHTs816 ALLOY WATER QUENCHED FROM 2300

  17. Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis

    NARCIS (Netherlands)

    Diaz-Gallo, Lina-Marcela; Espino-Paisán, Laura; Fransen, Karin; Gómez-García, María; van Sommeren, Suzanne; Cardeña, Carlos; Rodrigo, Luis; Mendoza, Juan Luis; Taxonera, Carlos; Nieto, Antonio; Alcain, Guillermo; Cueto, Ignacio; López-Nevot, Miguel A; Bottini, Nunzio; Barclay, Murray L; Crusius, J Bart; van Bodegraven, Adriaan A; Wijmenga, Cisca; Ponsioen, Cyriel Y; Gearry, Richard B; Roberts, Rebecca L; Weersma, Rinse K; Urcelay, Elena; Merriman, Tony R; Alizadeh, Behrooz Z; Martin, Javier

    2011-01-01

    BACKGROUND: The PTPN22 gene is an important risk factor for human autoimmunity. The aim of this study was to evaluate for the first time the role of the R263Q PTPN22 polymorphism in ulcerative colitis (UC) and Crohn's disease (CD), and to reevaluate the association of the R620W PTPN22 polymorphism w

  18. Differential Association of Two PTPN22 Coding Variants with Crohn's Disease and Ulcerative Colitis

    NARCIS (Netherlands)

    Diaz-Gallo, Lina-Marcela; Espino-Paisan, Laura; Fransen, Karin; Gomez-Garcia, Maria; van Sommeren, Suzanne; Cardena, Carlos; Rodrigo, Luis; Mendoza, Juan Luis; Taxonera, Carlos; Nieto, Antonio; Alcain, Guillermo; Cueto, Ignacio; Lopez-Nevot, Miguel A.; Bottini, Nunzio; Barclay, Murray L.; Crusius, J. Bart; van Bodegraven, Adriaan A.; Wijmenga, Cisca; Ponsioen, Cyriel Y.; Gearry, Richard B.; Roberts, Rebecca L.; Weersma, Rinse K.; Urcelay, Elena; Merriman, Tony R.; Alizadeh, Behrooz Z.; Martin, Javier

    2011-01-01

    Background: The PTPN22 gene is an important risk factor for human autoimmunity. The aim of this study was to evaluate for the first time the role of the R263Q PTPN22 polymorphism in ulcerative colitis (UC) and Crohn's disease (CD), and to reevaluate the association of the R620W PTPN22 polymorphism w

  19. 78 FR 59779 - Regulations Y and YY: Application of the Revised Capital Framework to the Capital Plan and Stress...

    Science.gov (United States)

    2013-09-30

    ... consolidated assets as reported by a bank holding company on its Consolidated Financial Statements for Bank..., Deputy Associate Director, (202) 263-4833, Constance Horsley, Manager, (202) 452-5239, or Ann McKeehan, Senior Supervisory Financial Analyst, (202) 973-6903, Division of Banking Supervision and...

  20. Effects of a Summer Mathematics Intervention for Low-Income Children: A Randomized Experiment

    Science.gov (United States)

    Lynch, Kathleen; Kim, James S.

    2017-01-01

    Prior research suggests that summer learning loss among low-income children contributes to income-based gaps in achievement and educational attainment. We present results from a randomized experiment of a summer mathematics program conducted in a large, high-poverty urban public school district. Children in the third to ninth grade (N = 263) were…

  1. Complexity and Automation Displays of Air Traffic Control: Literature Review and Analysis

    Science.gov (United States)

    2005-04-01

    described with Eucilidian geometry (Bieri, At- kins, Briar , Leoman, Miller, & Tripodi, 1966). In a similar fashion, Crokett (1965) used the con- cept...complexity-simplicity and predictive behavior. Journal of Abnormal and Social Psychology, 51, 263-268. Bieri, J., Atkins, A., Briar , S., Leoman, R. L

  2. Symposium on the Interface: Computing Science and Statistics (20th). Theme: Computationally Intensive Methods in Statistics Held in Reston, Virginia on April 20-23, 1988

    Science.gov (United States)

    1988-08-20

    John ". Hsieh, University of Toronto 3 This caper develops a precise method for constructing period life tables through estimation of death density...Falls Church VA 22041 Madison WI 53706 (703) 756-1818 (608) 263-3871 1 Ryan Barbara Statistics Department Ryan Thomas A. Stanford University Minitab

  3. Perceived Social Support and Locus of Control as the Predictors of Vocational Outcome Expectations

    Science.gov (United States)

    Isik, Erkan

    2013-01-01

    The purpose of this study was to examine the relationships of vocational outcome expectation to social support which is an environmental factor and locus of control which is a personal factor. With this purpose, using Social Cognitive Career Theory as the theoretical framework, 263 undergraduate students completed Vocational Outcome Expectations…

  4. Molecular Biogeochemistry of Modern and Ancient Marine Microbes

    Science.gov (United States)

    2010-02-01

    Oscillatoria neglecta Nostoc sp. Planktothrix agardhii Trichodesmium havanum Microcystis aeruginosa Leptolyngbya boryana Uncultured Synechocystis sp. Euglena ...Second, euglenids Euglena gracilis (Anding et al. 1971) and Astasia longa (Rohmer & Brandt 1973) and heterolobosea (Naegleria sp.; Raederstorff...Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. Eur. J. Biochem. 24, 259–263. (doi

  5. 75 FR 5925 - Proposed Flood Elevation Determinations

    Science.gov (United States)

    2010-02-05

    ... 2,300 None +260 Unincorporated Areas of feet downstream of Hot Spring County. Martin Luther King Boulevard. Approximately 1,300 None +263 feet downstream of Martin Luther King Boulevard. Town Creek... SECURITY Federal Emergency Management Agency 44 CFR Part 67 Proposed Flood Elevation Determinations...

  6. Data of evolutionary structure change: 1DJ2B-1ADIB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DJ2B-1ADIB 1DJ2 1ADI B B IGSLSQVSGVLGCQWGDEGKGKLVDILAQHFDIVARCQG...LLSEACPLILDYHVALDNAREKARGAKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKETFAEKLKEVMEYHNFQLVNYYKAEAVDYQKVLDDTMAVADI...LY CA 195 PHE CA 263 LYS CA 227 TYR CA 251 1ADI B 1ADIB 1 1ADI B 1ADI

  7. My Intelligence May Be More Malleable than Yours: The Revised Implicit Theories of Intelligence (Self-Theory) Scale Is a Better Predictor of Achievement, Motivation, and Student Disengagement

    Science.gov (United States)

    De Castella, Krista; Byrne, Donald

    2015-01-01

    The belief that intelligence is malleable has important consequences for achievement and motivation (Blackwell et al. "Child Development," v78, p246-263. 2007; Dweck, 1999; Robins & Pals, "Self and Identity," v1, p313-336, 2002). However, believing that it is possible to improve intelligence does not necessarily mean…

  8. The Best and the Rest: Revisiting the Norm of Normality of Individual Performance

    Science.gov (United States)

    O'Boyle, Ernest, Jr.; Aguinis, Herman

    2012-01-01

    We revisit a long-held assumption in human resource management, organizational behavior, and industrial and organizational psychology that individual performance follows a Gaussian (normal) distribution. We conducted 5 studies involving 198 samples including 633,263 researchers, entertainers, politicians, and amateur and professional athletes.…

  9. Explanatory Parent-Child Conversation Predominates at an Evolution Exhibit

    Science.gov (United States)

    Tare, Medha; French, Jason; Frazier, Brandy N.; Diamond, Judy; Evans, E. Margaret

    2011-01-01

    To investigate how parents support children's learning at an exhibit on evolution, the conversations of 12 families were recorded, transcribed, and coded (6,263 utterances). Children (mean age 9.6 years) and parents visited Explore Evolution, which conveyed current research about the evolution of seven organisms. Families were engaged with the…

  10. Preschool-Aged Children's Understanding of Gratitude: Relations with Emotion and Mental State Knowledge

    Science.gov (United States)

    Nelson, Jackie A.; de Lucca Freitas, Lia Beatriz; O'Brien, Marion; Calkins, Susan D.; Leerkes, Esther M.; Marcovitch, Stuart

    2013-01-01

    Developmental precursors to children's early understanding of gratitude were examined. A diverse group of 263 children was tested for emotion and mental state knowledge at ages 3 and 4, and their understanding of gratitude was measured at age 5. Children varied widely in their understanding of gratitude, but most understood some aspects of…

  11. 75 FR 67395 - Iron Construction Castings From Brazil, Canada, and China; Determinations

    Science.gov (United States)

    2010-11-02

    ... COMMISSION [Investigation Nos. 701-TA-249 and 731-TA-262, 263, and 265 (Third Review)] Iron Construction... countervailing duty order on heavy iron construction castings from Brazil, the antidumping duty order on heavy iron construction castings from Canada, and the antidumping duty orders on iron construction...

  12. Elaboración de referencias regionales sobre el crecimiento ponderal correspondiente a cada edad para los países donde la malaria es endémica a fin de optimizar la dosificación basada en la edad de los medicamentos contra la malaria

    NARCIS (Netherlands)

    Hayes, Daniel J.; van Buuren, Stef; ter Kuile, Feiko O.; Stasinopoulos, D. Mikis; Rigby, Robert A.; Terlouw, Dianne J.

    2015-01-01

    Methods: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than

  13. Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials = Développer des références régionales de croissance pour le rapport poids/âge dans les pays où le paludisme est endémique, afin d’optimiser la posologie des médicaments antipaludiques en fonction de l’âge = Elaboración de referencias regionales sobre el crecimiento ponderal correspondiente a cada edad para los países donde la malaria es endémica a fin de optimizar la dosificación basada en la edad de los medicamentos contra la malaria

    NARCIS (Netherlands)

    Hayes, D.J.; Buuren, S. van; Kuile, F.O. ter; Stasinopoulos, D.M.; Rigby, R.A.; Terlouw, D.J.

    2015-01-01

    Methods: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than

  14. Novel arenavirus, Zambia.

    Science.gov (United States)

    Ishii, Akihiro; Thomas, Yuka; Moonga, Ladslav; Nakamura, Ichiro; Ohnuma, Aiko; Hang'ombe, Bernard; Takada, Ayato; Mweene, Aaron; Sawa, Hirofumi

    2011-10-01

    To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA-positive rodents (Mastomys natalensis) among 263 captured. Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus-related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses.

  15. Novel Arenavirus, Zambia

    OpenAIRE

    Ishii, Akihiro; Thomas, Yuka; Moonga, Ladslav; Nakamura, Ichiro; OHNUMA, Aiko; Hang’ombe, Bernard; Takada, Ayato; MWEENE, Aaron; Sawa, Hirofumi

    2011-01-01

    To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA–positive rodents (Mastomys natalensis) among 263 captured. Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus–related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses.

  16. AcEST: BP913044 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 263|NEST_RAT Nestin OS=Rattus norvegicus GN=Nes PE=1 SV=2 31 3.4 sp|P18636|MBHL_RHILV Uptake hydrogenase lar...ge subunit OS=Rhizobi... 30 7.5 sp|P12636|MBHL_BRAJA Uptake hydrogenase large sub

  17. H v Council: Another Court breakthrough in the Common Foreign and Security Policy

    DEFF Research Database (Denmark)

    Butler, Graham

    2016-01-01

    , Tanzania (Case C-263/14) and H v. Council (Case C-455/14 P) address different questions, and with a third, Rosneft (Case C-72/15), being delivered later in the year. This sequence of judgments demonstrates the fluidity of CFSP dynamics. In this blog post, analysis will focus on the H v. Council judgment...

  18. The Development of Attentional Networks: Cross-Sectional Findings from a Life Span Sample

    Science.gov (United States)

    Waszak, Florian; Li, Shu-Chen; Hommel, Bernhard

    2010-01-01

    Using a population-based sample of 263 individuals ranging from 6 to 89 years of age, we investigated the gains and losses in the abilities to (a) use exogenous cues to shift attention covertly and (b) ignore conflicting information across the life span. The participants' ability to shift visual attention was tested by a typical Posner-type…

  19. Information Management: A Selective Bibliography

    Science.gov (United States)

    1986-07-01

    AND POLICY 24:1-169, 1985 "Automated Legislative Information Systems: A New Tool for Legal Research." S.B. Kauffman. LAW LIBRARY JOURNAL 76:233-263...Spring 1983 "A Brief History of Computer-Assisted Legal Research (OBAR Project)." William C. Harrington. LAW LIBRARY JOURNAL 77:543-556, Summer 1985 "A

  20. Inoculation of Scrapie with the Self-Assembling RADA-Peptide Disrupts Prion Accumulation and Extends Hamster Survival

    Science.gov (United States)

    Intercerebral inoculation of 263K Scrapie brain homogenate (PrPsc) with a self-assembling RADA-peptide (RADA) significantly delayed disease onset and increased hamster survival. Time of survival was dependent on the dose of RADA and pre-incubation with PrPsc prior to inoculation. RADA treatment resu...

  1. Synthesis and Physical Behavior of Ion-Containing, Segmented and Random Copolymer Elastomers

    Science.gov (United States)

    1987-01-01

    1970). 15. G. Popov and G. Schwarchula, Plast. U. Kautch., 26, 263(1979). 16. P. Guyot, J. C. Favier, H. Uytterhoeven, M. Fontanille , and P. Sigwalt...Polmr, 2L2, 1724(1981). 17. P. Guyot, J. C. Favier, N. Fontanille , and P. Sigwalt, Polymer, 23, 73(1982). 70 18. R. P. Foss, H. W. Jacobson, and W. H

  2. InterPro search result: AK069984 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK069984 J023036N01 IPR008921 DNA polymerase III clamp loader subunit, C-terminal s...uperfamily SSF48019 DNA polymerase III clamp loader subunits, C-terminal domain T263-354 2.8e-22 ...

  3. A Study of Alternative Approaches to Produce Obscuring Smoke with JP-8 in Vehicle Engine Exhaust Smoke Systems (VEESS)

    Science.gov (United States)

    1989-12-01

    values and Johnson-Grayson for the enthalpies. In the CHEMCAD II run, Soave- Redlich - Kwong models were used for both K-values and enthalpies. The...263 6a. NAME OF PERFORMING ORGANIZATION 6b. OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION Belvoir Fuels and Lubricants (If applicable ) Research

  4. Nanoscience: Single-molecule instant replay

    Science.gov (United States)

    Camillone, Nicholas

    2016-11-01

    A nanoscale imaging method that uses ultrashort light pulses to initiate and follow the motion of a single molecule adsorbed on a solid surface opens a window onto the physical and chemical dynamics of molecules on surfaces. See Letter p.263

  5. Do Hours Spent Viewing Television at Ages 3 and 4 Predict Vocabulary and Executive Functioning at Age 5?

    Science.gov (United States)

    Blankson, A. Nayena; O'Brien, Marion; Leerkes, Esther M.; Calkins, Susan D.; Marcovitch, Stuart D.

    2015-01-01

    We examined the impact of television viewing at ages 3 and 4 on vocabulary and at age 5 on executive functioning in the context of home learning environment and parental scaffolding. Children (N = 263) were seen in the lab when they were 3 years old and then again at ages 4 and 5. Parents completed measures assessing child television viewing and…

  6. Drug: D01073 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available organs 26 Epidermides 263 Suppurative dermatosis agents 2634 Antibiotics for external use D01073 Clindamycin... phosphate (JP16/USP) 6 Agents against pathologic organisms and parasites 61 Antibiotics...WITH CORTICOSTEROIDS G01AA Antibiotics G01AA10 Clindamycin D01073 Clindamycin phosphate (JP16/USP) J ANTIINF

  7. Drug: D01063 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ntamicin sulfate (JP16/USP) 2 Agents affecting individual organs 26 Epidermides 263 Suppurative dermatosis agents 2634 Antibiotics...ents against pathologic organisms and parasites 61 Antibiotics 613 Acting mainly on gram-positive and gram-n...in sulfate (JP16/USP) S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics

  8. Novel Cellulase Screening and Optimal Production from the Wood Decaying Xylariaceae: Daldinia Species.

    Science.gov (United States)

    Ng, I-Son; Chen, Po Ting; Ju, Yu-Ming; Tsai, Shau-Wei

    2010-10-21

    The highest cellulases production from Daldinia caldariorum 263 (D-263) was found among Daldinia eschscholzii and Daldinia childiae. Three cellulases, one xylanase and one β-glucosidase of the molecular weights 55, 43, 34, 30, and 105 kDa, respectively, were determined by zymographic sodium dodecyl sulfate polyacrylamide gel electrophoresis. From the N-terminal sequencing, the major cellulase CelA belonging to glycosyl hydrolase family 5 was determined. By following an orthogonal experiment design (L9), factors affecting the cultivation of D. caldariorum 263 are ranked as medium composition > temperature > pH ≥ FP (%). The optimum cultivation conditions for obtaining the best FPase (600 mU/ml) at 72 h are 150 rpm, 35 °C, pH 7, 0.2% soy peptone and 0.5% α-cellulose in minimal requirement medium. In comparison with Trichoderma reesei (ATCC26921) secreting 1,135 mU/ml of FPase after 6 days cultivation at pH 5, D. caldariorum 263 grew faster at 35 °C and produced the maximum FPase within 3 days at pH 7.

  9. Prostate Specific Expression of Maspin in a Transgenic Mouse Model: Implications in Prostate Carcinogenesis

    Science.gov (United States)

    2004-05-01

    metastasis talined by H&E. Arre•os ludicate tumor ells. expressing C2N-Maspin tumor cells had significant increase of apoptosis than that of C2N control... activity in human mammary epithelial cells [see comments]. Science, 263: 526-529, 1994. 5. Zhang, M., Maass, N., Magit, D., and Sager, R. Transactivation

  10. 75 FR 35330 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Comprehensive Ecosystem-Based...

    Science.gov (United States)

    2010-06-22

    ... while minimizing the effects on traditional fishing in the Deepwater Coral HAPCs. Additionally, the... Assessment/Fishery Impact Statement may be obtained from Karla Gore, Southeast Regional Office, NMFS, 263... 1: The Deepwater Shrimp Advisory Panel (AP) unanimously agreed on the alternative (Alternative...

  11. GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.

    Science.gov (United States)

    Negahdar, Maria; Aukrust, Ingvild; Johansson, Bente B; Molnes, Janne; Molven, Anders; Matschinsky, Franz M; Søvik, Oddmund; Kulkarni, Rohit N; Flatmark, Torgeir; Njølstad, Pål Rasmus; Bjørkhaug, Lise

    2012-11-01

    GCK-MODY, dominantly inherited mild fasting hyperglycemia, has been associated with >600 different mutations in the glucokinase (GK)-encoding gene (GCK). When expressed as recombinant pancreatic proteins, some mutations result in enzymes with normal/near-normal catalytic properties. The molecular mechanism(s) of GCK-MODY due to these mutations has remained elusive. Here, we aimed to explore the molecular mechanisms for two such catalytically 'normal' GCK mutations (S263P and G264S) in the F260-L270 loop of GK. When stably overexpressed in HEK293 cells and MIN6 β-cells, the S263P- and G264S-encoded mutations generated misfolded proteins with an increased rate of degradation (S263P>G264S) by the protein quality control machinery, and a propensity to self-associate (G264S>S263P) and form dimers (SDS resistant) and aggregates (partly Triton X-100 insoluble), as determined by pulse-chase experiments and subcellular fractionation. Thus, the GCK-MODY mutations S263P and G264S lead to protein misfolding causing destabilization, cellular dimerization/aggregation and enhanced rate of degradation. In silico predicted conformational changes of the F260-L270 loop structure are considered to mediate the dimerization of both mutant proteins by a domain swapping mechanism. Thus, similar properties may represent the molecular mechanisms for additional unexplained GCK-MODY mutations, and may also contribute to the disease mechanism in other previously characterized GCK-MODY inactivating mutations.

  12. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Sarah L. [Univ. of California, Berkeley, CA (United States)

    2008-01-01

    Several reactions producing odd-Z transactinide compound nuclei were studiedwith the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus ator near the same excitation energy with similar values of angular momentum via differentnuclear reactions. In doing so, it can be determined if there is a preference in entrancechannel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's"Fusion By Diffusion" model is nearly identical forthe two reactions. Additionally, because the same compound nucleus is produced, theexit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs' cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrancechannel in these paired reactions. Charge equilibration immediately prior to fusionleading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi(52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35$+19\\atop{-9}$ ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki

  13. Research of Video Phone Terminal Based on Trimedia Platform%基于Trimedia平台的可视电话终端研究

    Institute of Scientific and Technical Information of China (English)

    赵海涛; 蔡万景

    2009-01-01

    This paper introduces the H.324 criterion established by ITU-T and the Trimedia phtform manufactured by Philips for multi-media application, researchs a blue print optimizing H.263 based on TM1300 chipsets and the controling arithmetic of video coding,and designs a video phone terminal system based on a Trimedia phtform.%介绍了ITU-T制订的H.324框架标准和Philips公司新近推出的针对多媒体应用的Tfimedia开发平台,研究了基于TM1300芯片的H.263优化方法和视频编码中的码率控制算法,设计实现了基于Trimedia平台的可视电话终端系统.

  14. Update of monotherapy trials with the new anti-androgen, Casodex (ICI 176,334). International Casodex Investigators

    DEFF Research Database (Denmark)

    Iversen, P

    1994-01-01

    Casodex (ICI 176,334) is a non-steroidal anti-androgen, which has a half-life compatible with once-daily oral dosing. In an open, phase II study on 267 patients given Casodex, 50 mg/day, an overall objective response (i.e. partial regression) was seen in 55.5% of patients (146 of 263) with a furt......Casodex (ICI 176,334) is a non-steroidal anti-androgen, which has a half-life compatible with once-daily oral dosing. In an open, phase II study on 267 patients given Casodex, 50 mg/day, an overall objective response (i.e. partial regression) was seen in 55.5% of patients (146 of 263...

  15. Korduv pisivargus ja süstemaatiline vargus. Riigikohtu kriminaalkolleegiumi otsus asjas 3-1-1-36-07 / Jaan Sootak

    Index Scriptorium Estoniae

    Sootak, Jaan, 1948-

    2008-01-01

    Kommentaar Riigikohtu lahendile 3-1-1-36-07 (Ivailo Siimani kaitsja vandeadvokaadi vanemabi Andres Veski ja Margo Küti kaitsja vandeadvokaat Anu Pärteli kassatsioonid Tartu Ringkonnakohtu 13. veebruari 2007. a kohtuotsuse peale kriminaalasjas Ivailo Siimani süüdistuses KarS § 199 lg 2 p-de 4, 7 ja 8; § 263 p-de 1 ja 4 järgi ning Margo Küti süüdistuses KarS § 200 lg 2 p 7, § 199 lg 2 p-de 4, 7, 8, § 263 p-de 1, 2, 3 ja § 25 lg-te 1 ja 2 ning § 209 lg 2 p 1 järgi)

  16. Identificação e quantificação das antocianinas do fruto do açaizeiro (Euterpe oleracea Mart Identification and quantification of the anthocyanins from the fruit of açai (Euterpe oleracea Mart

    Directory of Open Access Journals (Sweden)

    Florinda O. BOBBIO

    2000-12-01

    Full Text Available Do extrato aquoso, congelado e liofilizado dos frutos do açaizeiro, foram extraídas as antocianinas e após purificação e separação das duas principais frações as mesmas foram identificadas usando métodos químicos, espectroscópicos e CLAE. As antocianinas foram identificadas como cianidina-3- arabinosídeo e cianidina-3-arabinosil-arabinosídeo. O teor de antocianinas totais no caso do fruto do açaizeiro foi determinado e o valor encontrado foi de 263mg/100g casca.From the liophylized commercialy frozen extract of the fruit of Euterpes oleracea (açaí two anthocyanins were isolated and identified as cianidin-3-arabinoside and cyanidin-3-arabinosylarabinoside. The percentage of total anthocyanins in the peels of the fruits was 263 mg/100g peel.

  17. "Parasitic Contamination of Vegetables from Farms and Markets in Tehran"

    Directory of Open Access Journals (Sweden)

    MJ Gharavi

    2002-09-01

    Full Text Available Because of endemic parasitological infectious diseases in Iran and contaminated vegetables, as one of the most important ways of contamination, carried out a parasitical study on 263 vegetable samples from 44 farms in the suburbs of Tehran city, and also 166 vegetables samples from 20 green grocery markets in the same city. From 263 samples of farms 147 cases (65% of contamination were recorded, of which 43 cases (16/5% of human pathogenic parasites were isolated. In this study various techniques were used such as: Baermann funnel, centrifuging of plants and soil, temporal precipitation procedure and so on. Ova and parasites such as Ascaris lumbricoides, Trichuris trichiura, Trichostrongylus sp. Toxocara sp. Larvae of Nematodes, protozoa cysts like Amoeba sp. Giardia lamblia and some flagellatae were seen. The highest percent of contamination was detected in leek and parsley and the lowest one was detected in tarragon. The results show that vegetables could be a potential source of parasitic infection.

  18. AcEST: BP912029 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000012_C02 263 Adiantum capillus-veneris mRNA. clone: YMU001_000012_C02. BP9120...29 CL2240Contig1 Show BP912029 Clone id YMU001_000012_C02 Library YMU01 Length 263 Definition Adiantum ca...pillus-veneris mRNA. clone: YMU001_000012_C02. Accession BP912029 Tissue type prothallium Developmental stag...ein database search programs, Nucleic Acids Res. 25:3389-3402. Query= BP912029|Adiantum capillus-veneris mRN... database search programs, Nucleic Acids Res. 25:3389-3402. Query= BP912029|Adiantum capillus-veneris mRNA,

  19. Dicty_cDB: SLB693 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB693 (Link to dictyBase) - - - Contig-U16455-1 SLB693Z (Link... to Original site) - - SLB693Z 615 - - - - Show SLB693 Library SL (Link to library) Clone ID SLB693 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB6-D/SLB693Q.Seq.d/ Representative seq. ID SLB69...3Z (Link to Original site) Representative DNA sequence >SLB693 (SLB693Q) /CSM/SL/SLB6-D/SLB693Q.Seq.d/ XXXXX...gation factor ... 263 3e-69 AY582829_1( AY582829 |pid:none) Acanthamoeba culbertsoni ef1a gene... 263 4e-69

  20. Memory-Optimized Software Synthesis from Dataflow Program Graphs with Large Size Data Samples

    Directory of Open Access Journals (Sweden)

    Hyunok Oh

    2003-05-01

    Full Text Available In multimedia and graphics applications, data samples of nonprimitive type require significant amount of buffer memory. This paper addresses the problem of minimizing the buffer memory requirement for such applications in embedded software synthesis from graphical dataflow programs based on the synchronous dataflow (SDF model with the given execution order of nodes. We propose a memory minimization technique that separates global memory buffers from local pointer buffers: the global buffers store live data samples and the local buffers store the pointers to the global buffer entries. The proposed algorithm reduces 67% memory for a JPEG encoder, 40% for an H.263 encoder compared with unshared versions, and 22% compared with the previous sharing algorithm for the H.263 encoder. Through extensive buffer sharing optimization, we believe that automatic software synthesis from dataflow program graphs achieves the comparable code quality with the manually optimized code in terms of memory requirement.

  1. 漫漫平台路 竞技对战平台的过去、现状及未来

    Institute of Scientific and Technical Information of China (English)

    Byron

    2006-01-01

    大约在98年的时候,国内的星际争霸用户去北方的263战网和南方的湖南战网开始了最初的网络对战,99年,更多的战网如雨后春笋一般层出不穷,但263和湖南提供了更稳定的服务,再加上游戏的发展和网络的普及,它们分立南北,逐渐演变成国内最火爆的星际战网。

  2. Evaluating the effectiveness of SW-only video coding for real-time video transmission over low-rate wireless networks

    Science.gov (United States)

    Bartolini, Franco; Pasquini, Cristina; Piva, Alessandro

    2001-04-01

    The recent development of video compression algorithms allowed the diffusion of systems for the transmission of video sequences over data networks. However, the transmission over error prone mobile communication channels is yet an open issue. In this paper, a system developed for the real time transmission of H263 video coded sequences over TETRA mobile networks is presented. TETRA is an open digital trunked radio standard defined by the European Telecommunications Standardization Institute developed for professional mobile radio users, providing full integration of voice and data services. Experimental tests demonstrate that, in spite of the low frame rate allowed by the SW only implementation of the decoder and by the low channel rate a video compression technique such as that complying with the H263 standard, is still preferable to a simpler but less effective frame based compression system.

  3. Black carbon and organic carbon emissions from wildfires in Mexico

    OpenAIRE

    XÓCHITL CRUZ NÚÑEZ; LOURDES VILLERS RUIZ; CARLOS GAY GARCÍA

    2014-01-01

    In Mexico, approximately 7650 wildfires occur annually, affecting 263 115 hectares of land. In addition to their impact on land degradation, wildfires cause deforestation, damage to ecosystems and promote land use change; apart from being the source of emissions of toxic substances to the environment (i.e., hydrogen cya - nide, black carbon and organic carbon). Black carbon is a short-lived greenhouse pollutant that also promotes snow and ice melting and decreased rainfall; it has an estimate...

  4. Longitudinal Associations between Children’s Understanding of Emotions and Theory of Mind

    OpenAIRE

    O’Brien, Marion; Weaver, Jennifer Miner; Nelson, Jackie A.; Calkins, Susan; Leerkes, Esther; Marcovitch, Stuart

    2011-01-01

    Theory of mind competence and knowledge of emotions were studied longitudinally in a sample of preschoolers aged 3 (n =263) and 4 (n =244) years. Children were assessed using standard measures of theory of mind and emotion knowledge. Three competing hypotheses were tested regarding the developmental associations between children’s theory of mind abilities and their knowledge of emotions. First, that an understanding of emotion develops early and informs children’s understanding of others’ thi...

  5. Ploidy of Bovine Nuclear Transfer Blastocysts Blastomere Donors

    DEFF Research Database (Denmark)

    Booth, P J; VIUFF, D; THOMSEN, P D;

    2000-01-01

    .2 (mean SD) nuclei/embryo were examined. Of these 16, 7 embryos (43.8 were potentially abnormal because in these, 1.1 1.4 5.3 7.5 26.3 30.4 and 66.2% % of the nuclei had a chromosome composition deviating from the diploid condition, indicating a wide degree of variation between embryos. These errors...

  6. The total chromatic number of regular graphs of high degree

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The total chromatic number χT (G) of a graph G is the minimum number of colors needed to color the edges and the vertices of G so that incident or adjacent elements have distinct colors. We show that if G is a regular graph and d(G) 32 |V (G)| + 263 , where d(G) denotes the degree of a vertex in G, then χT (G) d(G) + 2.

  7. Rapid Mission Assurance Assessment via Sociotechnical Modeling and Simulation

    Science.gov (United States)

    2015-05-01

    Bull , McDermott, & Choi, 1994). Howard’s dissertation (1997) has an extensive review of taxonomy attempts including the use of “results Categories...creators. Creators execute the hard and expensive scientific efforts of proof of possible; copyists execute the efforts for reproduction and imitation...E., Bull , A. R., McDermott, J. P., & Choi, W. S. (1994). A taxonomy of computer program security flaws. ACM Computing Surveys (CSUR), 26(3), 211

  8. Dynamics and Controls in Maglev Systems

    Science.gov (United States)

    1992-09-01

    and Alscher, H. 1986. "The Magnetic Train Transrapid 06," Proc. Int. Conf. Maglev and Linear Drives, May 14-16, 1986, Vancouver, B.C., Canada, Publ. by...AD-A263 087 ANL-92/43It Il~l Iif IIt[11 Materials and Components Dynamics and Controls Technology Division Materials and Components in Maglev ...Argonne, Illinois 60439 Distribution Category: All Transportation Systems Reports (UC-330) Dynamics and Controls in Maglev Systems by Y. Cai and S. S

  9. Behavior and Attitudes under Crisis Conditions: Selected Issues and Findings.

    Science.gov (United States)

    1984-02-01

    263-280 (1971). Ajzen , Icek , Russell K. Daroch, Martin Fishbein, and John A. Hornik, "Looking Backward Revisited: A Reply to Deutscher," American...Personality and Social Psychology, 27, 41-57 (1973). Ajzen , Icek and Martin Fishbein, Belief, Attitude, Intention and Behavior: An Introduction to...Theory and Research, Addison-Wesley Publishing Company, Reading, Massachusetts (1975). Ajzen , Icek and Martin Fishbein, "Factors Influencing Intention

  10. Extraction and recovery technique for myxozoan parasites from the Piaractus mesopotamicus kidney embedded in paraffin

    OpenAIRE

    Manrique, Wilson G. [UNESP; Figueiredo,Mayra A P; Claudiano, Gustavo S.; Martins,Mauricio L.; Moraes, Flávio R.

    2013-01-01

    http://dx.doi.org/10.5007/2175-7925.2013v26n4p263Tissues fixed and embedded in paraffin for histopathological studies keep their cell characteristics. There are several protocols for extracting genetic material from tissue embedded in paraffin, but there is no protocol for material aimed at the direct identification of parasites. The lack of techniques which describe the recovery of parasites from tissue embedded in paraffin has led us to test a technique for recovering myxosporean parasites ...

  11. Domain Modeling: NP_060012.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_060012.3 chr1 ADR1 DNA-BINDING DOMAIN FROM SACCHAROMYCES CEREVISIAE, NMR, 25 STR...UCTURES c2adra_ chr1/NP_060012.3/NP_060012.3_holo_242-299.pdb psi-blast 244A,246A,247M,249R,263D,275A,277G,278D,280I,296M,297N _ZN 0 ...

  12. Africa’s Evolving Infosystems: A Pathway to Security and Stability

    Science.gov (United States)

    2011-03-01

    one million megabytes equals a terabyte. Put differently, 1,048,576 (1,0242) megabytes = 1 terabyte. 67 Amartya Sen , Poverty and Famines: An Essay...on Entitlements and Deprivation (Oxford: Oxford University Press, 1981); see also Amartya Sen , “Development: Which Way Now?” The Economic Journal 93...no. 372 (December 1983). 68 Jean Drèze and Amartya Sen , The Political Economy of Hunger (Oxford: Clar- endon Press, 1990), 263. There are echoes of

  13. Medical Surveillance Monthly Report (MSMR). Volume 7, Number 4, April 2001

    Science.gov (United States)

    2001-04-01

    Peritonsillar abscess 38 8.4 Complications due to certain procedures 53 5.8 Chronic disease of tonsils and adenoids 38 8.4 Sprains and strains of knee and leg...16,091 (59) 11,635 (56) 431 (71) Kidney stones 12,352 (66) 5,176 (67) 1,260 (42) Nephritis and nephrosis 3,598 (82) 1,263 (90) 446 (69) Benign prostatic

  14. Military Handbook: Electrostatic Discharge Control Handbook for Protection of Electrical and Electronic Parts, Assemblies and Equipment (Excluding Electrically Initiated Explosive Devices (Metric)

    Science.gov (United States)

    2007-11-02

    dispersive X- ray analysis of two of the oxide rupture sites showed aluminum (alloyed gate 46 MIL-HDBK-263B APPENDIX C metallization) in one case and...device is very effective for various CMOS processes ranging from 2 um abrupt junctions to 1 Am lightly doped drain ( LDD ) junctions with silicided...the ease of evenly dispersing the active ingredients across the surfaces being treated. Surfactants, for static electricity control, consist of

  15. International Conference on Defects in Semiconductors (19th), ICDS-19, Held in Aveiro, Portugal on 21-25 July 1997, Part 1

    Science.gov (United States)

    1998-01-23

    new Cultural and Congress Centre in Aveiro, Portugal. Here 263 delegates presented new data on defects in semiconductors, surveyed current knowlege... Turismo Rota da Luz Caves Säo Joäo Caves Alianca We also acknowledge the support in the form of staff time and facilities given to the conference by the...Scientific Research (1997 and 1998) on Kiban-B from the Ministry of Education, Science and Culture , Japan. References. 1. T.S. Plaskett, Trans. Metall. Soc

  16. Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

    Science.gov (United States)

    Trivellin, G.; Daly, A.F.; Faucz, F.R.; Yuan, B.; Rostomyan, L.; Larco, D.O.; Schernthaner-Reiter, M.H.; Szarek, E.; Leal, L.F.; Caberg, J.-H.; Castermans, E.; Villa, C.; Dimopoulos, A.; Chittiboina, P.; Xekouki, P.; Shah, N.; Metzger, D.; Lysy, P.A.; Ferrante, E.; Strebkova, N.; Mazerkina, N.; Zatelli, M.C.; Lodish, M.; Horvath, A.; de Alexandre, R. Bertollo; Manning, A.D.; Levy, I.; Keil, M.F.; de la Luz Sierra, M.; Palmeira, L.; Coppieters, W.; Georges, M.; Naves, L.A.; Jamar, M.; Bours, V.; Wu, T.J.; Choong, C.S.; Bertherat, J.; Chanson, P.; Kamenický, P.; Farrell, W.E.; Barlier, A.; Quezado, M.; Bjelobaba, I.; Stojilkovic, S.S.; Wess, J.; Costanzi, S.; Liu, P.; Lupski, J.R.; Beckers, A.; Stratakis, C.A.

    2015-01-01

    BACKGROUND Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. RESULTS We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein–coupled receptor, was overexpressed in patients’ pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone–producing cells. CONCLUSIONS We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.) PMID:25470569

  17. Organizational Linkages: Understanding the Productivity Paradox,

    Science.gov (United States)

    1994-01-01

    that the number of discriminable subfactors for this component is a manageable num- ber, and that it would be quite possible to build a systematic...e.g., Brewer and Kramer, 1985; Tajfel , 1982). They may have little opportunity or eagerness to learn from others on the team, which will impede the ex...similarity effects on frequency of interaction in a class of naval recruits. Sociometry 39:263-269. Tajfel , H. 1982 Social psychology of intergroup relations

  18. Association between 8-oxo-7,8-dihydroguanine excretion and risk of lung cancer in a prospective study

    DEFF Research Database (Denmark)

    Loft, Steffen; Svoboda, Peter; Kawai, Kazuaki

    2011-01-01

    in a population-based cohort of 25,717 men and 27,972 women aged 50-64 years with 3-7 years follow-up. We included 260 cases with lung cancer and a subcohort of 263 individuals matched on sex, age, and smoking duration for comparison. Urine collected at entry was analysed for 8-oxoGua by HPLC with electrochemical...

  19. Checklist of butterflies (Insecta: Lepidoptera) from Serra do Intendente State Park - Minas Gerais, Brazil

    Science.gov (United States)

    Nery, Izabella; Carvalho, Natalia

    2014-01-01

    Abstract In order to contribute to the butterflies’ biodiversity knowledge at Serra do Intendente State Park - Minas Gerais, a study based on collections using Van Someren-Rydon traps and active search was performed. In this study, a total of 395 butterflies were collected, of which 327 were identified to species or morphospecies. 263 specimens were collected by the traps and 64 were collected using entomological hand-nets; 43 genera and 60 species were collected and identified. PMID:25535482

  20. 77 FR 18651 - Qualifying Urban Areas for the 2010 Census

    Science.gov (United States)

    2012-03-27

    ...*.. 58,875 Lexington-Fayette, KY 290,263 Lima, OH 72,852 Lincoln, NE 258,719 Little Rock, AR 431,388... Marcos, TX 52,826 Santa Barbara, CA 195,861 Santa Clarita, CA 258,653 Santa Cruz, CA 163,703 Santa Fe, NM 89,284 Santa Maria, CA 130,447 Santa Rosa, CA 308,231 Sarasota--Bradenton, FL 643,260...

  1. Domain Modeling: NP_002011.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_002011.2 chr5 Crystal structure of the exctracellular domain of the receptor tyr...osine kinase, Kit p2ec8a_ chr5/NP_002011.2/NP_002011.2_holo_26-549.pdb psi-blast 149N,150R,151K,152D,227N,263T,311K,313N,314N,315G,318R,320R,340G,343L,380S,381P NAG 0 ...

  2. Endogenous 6-Hydroxymelatonin Excretion and Subsequent Risk of Breast Cancer: A Prospective Study

    Science.gov (United States)

    2008-03-01

    a group of 29 older women 40 to 70 years old was found to correlate well – however, whether smoking may have differentially affected these findings...generalized estimating equation approach. Biometrics 1988;44(4):1049-1060. 24. Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I...overnight and 24 hour collection to measure urinary catecholamines. J Clin Epidemiol 1995;48(2):263-7. 39. Janicki-Deverts D, Zilles K, Cohen S, Baum

  3. Introduction pages

    OpenAIRE

    2015-01-01

    Introduction Pages and Table of Contents Research ArticlesInsulin Requirements in Relation to Insulin Pump Indications in Type 1 DiabetesPDFGabriela GHIMPEŢEANU, Silvia Ş. IANCU, Gabriela ROMAN, Anca M. ALIONESCU259-263Comparative Antibacterial Efficacy of Vitellaria paradoxa (Shea Butter Tree) Extracts Against Some Clinical Bacterial IsolatesPDFKamoldeen Abiodun AJIJOLAKEWU, Fola Jose AWARUN264-268A Murine Effort Model for Studying the Influence of Trichinella on Muscular Activity of MicePDF...

  4. GENERAL GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>20071601 Yin Yanhong (Qingdao Institute of Marine Geology, Qingdao 266071, China); Sun Jiashi Discovery of Qingdao Iron Meteorite and Its Chemical Composition and Mineralogy (Marine Geology & Quaternary Geology, ISSN0256-1492, CN37-1117/P, 26(3), 2006, p.121-124, 3 illus., 2 tables, 9 refs.)Key words: iron meteorites, Shandong Province The Qingdao iron meteorite was found in May, 2004.

  5. Choosing a Moral Framework for the War on Terror

    Science.gov (United States)

    2002-06-01

    41 Jay M. Feinman , Law 101: Everything You Need to Know About the American Legal System (New York: Oxford University Press, 2000), 263. 19 States...enforcement investigation procedure, and the adversary system.51 Feinman notes that the burden is upon the state in the criminal justice system: “All...investigators. After the Khobar towers bombing in 1996, for example, the Saudi Arabian 51 Feinman , 301

  6. `One Church, One People, One Emperor’ - Strategic Challenges for the Serbian Orthodox Church in Post-Milosevic Serbian Society

    Science.gov (United States)

    2006-06-01

    Easte 11 Variou cultura nationa the inte of universal rights, fits well with civic nationalism, rather than ethnic nationalism. thodox Church have...Church but to the majority of Serbs as well. The dream of returning Kosovo to Serbia fits into the doctrine of collective rights by asserting a...not to imply th continue to be many more fits and starts in the process. 263 The Croatian Catholic bishops did not attend this conference, though

  7. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

    OpenAIRE

    Kascsak, R J; Rubenstein, R; Merz, P A; Carp, R I; Robakis, N. K.; Wisniewski, H M; Diringer, H

    1986-01-01

    Scrapie-associated fibrils (SAFs) are abnormal filamentous structures that are uniquely associated with unconventional slow virus diseases. The antigenic relationships of SAFs from animals infected with four biologically distinct scrapie strains were investigated by using antisera raised to purified SAF proteins. Rabbit antisera were raised to SAFs isolated from mice infected with the ME7 scrapie strain and to SAFs isolated from hamsters infected with the 263K scrapie strain. A strong antigen...

  8. Innovating Petroleum Processing Technology to Push on Development of China's Petroleum Refining Industry

    Institute of Scientific and Technical Information of China (English)

    Hou Fusheng

    2002-01-01

    @@ 1 Introduction The petroleum processing industry of China has been developing very fast. By the end of 1999 the total crude processing capacity of China reached 263 Mt/a, and 182 million tons of crude oils were processed in 1999. The annual average GDP growth in China is projected to be 7% during the "Tenth Five-Year Plan" period, while the corresponding growth in consumption of petroleum products is forecast to reach 4.7%.

  9. 基于远程医疗的视频通信系统%A Video Communication System for Telemedecine

    Institute of Scientific and Technical Information of China (English)

    刘立庄; 王凯; 周秦武; 卞正中

    2002-01-01

    对基于互联网的点对点视频通信系统做了深入的研究,进行了实际应用系统设计.并按照ITU-TH263协议及相关标准实现了基于低比特流的视频数据压缩编码技术.

  10. Federal R&D Funding Shows Strong Recent Rise But Little Real Growth in FY 1978. Science Resources Studies Highlights, October 17, 1977.

    Science.gov (United States)

    National Science Foundation, Washington, DC. Div. of Science Resources Studies.

    This document reports results of a review of estimated 1977 federal research and development (R&D) funding and requested 1978 federal R&D funding. Highlights include: 1978 estimated R&D total is $26.3 billion, an increase of 7.6% over 1977; average annual R&D growth rate for the period 1974-78 has risen to 10.9% compared to 1.5%…

  11. AcEST: DK951376 [AcEST

    Lifescience Database Archive (English)

    Full Text Available terized RING finger protein C2F3.16... 134 6e-31 sp|Q6CIK2|HOT13_KLULA Helper of Tim protein 13 OS=Kluyverom...in beta-1 OS=Pongo abelii GN=ITGB1 PE... 33 1.7 sp|P36078|HOT13_YEAST Helper of T...+ N H C+ Sbjct: 253 PISVFNTHRCI 263 >sp|Q6CIK2|HOT13_KLULA Helper of Tim protein

  12. "Locus standi" of European regions with legislative powers

    OpenAIRE

    Bruno Martín Baumeister

    2011-01-01

    This contribution offers a response to two questions: firstly, what forms ofappeal does a region with legislative powers have to challenge Communitylegislation?; secondly, what does the call for of a privileged action for annulmentconsist of for certain regions in agreement with Art. 263.2 TFUE / 230.2TCE? This contribution presents (1) the concept of region with legislativepowers, (2) the most frequent petitum of the actions used for the infringementof regional powers, (3) the internal coord...

  13. Speckle Interferometry at the U.S. Naval Observatory. 19th

    Science.gov (United States)

    2013-09-01

    decades ago. Before these measures are published they will need to be confirmed in a new observ- ing season to account for any other errors such as pointing...for subsequent observing seasons . These 2553 measures were grouped into 1584 mean relative positions, including 11 confirmations of double stars with...designation, but instead is designated CHR 263 (CHR = Center for High Angular Resolution Astronomy ). This anonymous binary was observed in 1982 with the

  14. Leading Preparedness for Local Fire Agencies

    Science.gov (United States)

    2014-12-01

    York City fire in 1835, the Chicago fire in 1871, and the 1906 San Francisco Earthquake drove an ad-hoc approach to emergency management over the...management system approach. The first is from ASIS International. ASIS is a member organization comprised of security practitioners from the public and...The ASIS standard, ASIS SPC.1-2009 Organizational Resilience, describes itself as a management system standard.263 The second approved standard is

  15. Ploidy of Bovine Nuclear Transfer Blastocysts Blastomere Donors

    DEFF Research Database (Denmark)

    Booth, P J; VIUFF, D; THOMSEN, P D;

    2000-01-01

    comprised mainly triploid (8.2 6 10.3 [0–26.3]: SD [range]) and tetraploid (10.6 6 19.9 [0–54.9]) nuclei with other ploidy com- binations accounting for only 0.9 6 2.1 [0–2.1]% of deviant nuclei. The proportion of com- pletely normal nuclear transfer embryos was no less than those produced by in vitro...

  16. The U.S. Personnel Recovery Architecture under Chief of Mission Responsibility: Department of State and Department of Defense Coordination

    Science.gov (United States)

    2013-05-22

    Tamaulipas (see figure 15). After the storm, Mexico’s Secretariat of National Defense (SEDENA) deployed 800 troops from the 8th Military Zone to... Tamaulipas under Plan DN-III-E to help aid operations (López Acosta 2012). Prior to landfall, the troops enforced mandatory evacuations of residents of...the affected areas. In 72 Tamaulipas , 263,000 people were affected by Hurricane Alix, and 2,260 homes were flooded. Additionally, 80,000 were

  17. Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada.

    OpenAIRE

    Martineau, Daniel; Lemberger, Karin; Dallaire, André; Labelle, Philippe; Lipscomb, Thomas P; Michel, Pascal; Mikaelian, Igor

    2002-01-01

    A population of approximately 650 beluga (Delphinapterus leucas) inhabits a short segment of the St. Lawrence estuary (SLE). Over 17 years (1983-1999), we have examined 129 (or 49%) of 263 SLE beluga carcasses reported stranded. The major primary causes of death were respiratory and gastrointestinal infections with metazoan parasites (22%), cancer (18%), and bacterial, viral, and protozoan infections (17%). We observed cancer in 27% of examined adult animals found dead, a percentage similar t...

  18. Health Care in Mexico: Is U.S. Partnership/Intervention an Advisable Course of Action?

    Science.gov (United States)

    2011-10-26

    Seguro Social, Last modified on July 15, 2011, http://www.imss.gob.mx/en/institute. html (accessed 4 September 2011). 3 access.2 The IMSS, by its...http:// hosted.law.wisc.edu /wilj/issues/26/3/kinney.pdf, 948 (accessed 4 September 2011). 3 Instituto Mexicano del Seguro Social, Last modified on...more focused on the medical procedures and less on the associated hygiene practices. Moving on from the Ohio University study, an increasingly popular

  19. In Search of an Effective in vivo Reactivator for Organophosphorus Nerve Agent-Inhibited Acetylcholinesterase in the Central Nervous System

    Science.gov (United States)

    2012-01-01

    Berends, D.M.W. Elskamp, L.A. Kepner, E. Meeter and R.P.L.S. Visser, The prophylactic value of oximes against organophosphate poisoning , In: SIPRI...new antidote drug combination (Atropine-HI-6-prodiazepam) for treatment of organophosphate poisoning , Eur. J. Pharm. Sci., 9(2000), 259–263. [9] J...Clement, Efficacy of pro-PAM (N-methyl-1,6-dihydropyridine-2- carbaldoxime hydrochloride) as a prophylaxis against organophosphate poisoning

  20. Tertiary Oximes on Brain Acetylcholinesterase and Central Excitatory Effects of Nerve Agents

    Science.gov (United States)

    2012-01-01

    quences of Organophosphate Poisoning in the CNS, Transworld Research Network: Kerala, India, pp. 111-133. 18. Shih T-M, Skovira JW, O’Donnell, JC and...Benschop HP, De Jong LRA, Vink JAJ, et al. 1976. The prophylactic value of oximes against organophosphate poisoning . In: SIPRI, Medical Protection...for treatment of organophosphate poisoning , Eur. J. Pharm. Sci. 9: 259–263. 24. Vallejo-Freire AA. 1951. A simple technique for repeated collection

  1. Checklist of butterflies (Insecta: Lepidoptera from Serra do Intendente State Park - Minas Gerais, Brazil

    Directory of Open Access Journals (Sweden)

    Izabella Nery

    2014-11-01

    Full Text Available In order to contribute to the butterflies’ biodiversity knowledge at Serra do Intendente State Park - Minas Gerais, a study based on collections using Van Someren-Rydon traps and active search was performed. In this study, a total of 395 butterflies were collected, of which 327 were identified to species or morphospecies. 263 specimens were collected by the traps and 64 were collected using entomological hand-nets; 43 genera and 60 species were collected and identified.

  2. Air University Library Index to Military Periodicals. January - March 1994. Volume 45, Number 1

    Science.gov (United States)

    1994-03-01

    E~e 2 no 10(11.r Fare Jowurnl laakwaatid 131 so?7 (Fab Rusia sf p26-3 󈨢) p25 AIRPLANES. TANKER - Russia Saeypivieeay James D. Teig...i Aimed For e...States A n SLas DEFENSE INDUSTRY AND TRADE Std and FIuMc~ rGqsA~ nog I(Ik9.. Rusia Saet iy h number (avoiin serious SAUDI ARABIA DOCTRINE - Armed Forme

  3. microRNAs: Novel Breast Cancer Susceptibility Factors in Caucasian and African American Women

    Science.gov (United States)

    2012-06-01

    informed consent and to query participants on a number of potential risk factors, including medical history, family history of cancer, diet , physical...0.07) 0.99 (0.03) 0.07 Count (%) Count (%) Count (%) Count (%) Menopausal status 0.14 0.17 Premenopausal 337 (61.6) 263 (57.0) 235...associated with breast cancer risk (Table 2), but there were no associations in EA women for any haplotypes. Stratified analysis by menopausal

  4. Gestational diabetes mellitus diagnosed in different periods of gestation and neonatal outcome

    Directory of Open Access Journals (Sweden)

    Aqueela Ayaz

    2009-01-01

    Full Text Available Objective: To evaluate the maternal and neonatal out-comes in women diagnosed as gestational diabetes mel-litus (GDM in different periods of pregnancy.Materials and Methods: This descriptive observational study was carried out from 1st January 2007 to 31th De-cember 2007 in the department of Obstetrics and Gyne-cology of a 1300 bedded tertiary care hospital "Bahawal Victoria Hospital" in Bahawalpur, Pakistan. Seventy six pregnant women met the inclusion criteria of diabetes diagnosed on the basis of the Oral glucose tolerance test (OGTT according to the National Diabetic Data Group. The study subjects were divided on the basis of gestational age at the first time diagnosis of GDM in the current pregnancy into group A (gestational age 13-23 weeks, group B (24-30 weeks and group C (31-36 weeks.Results: Out of total study subjects, 19 (25% were di-agnosed as GDM between 13-23 weeks of gestation (early-onset, 25 (32.9% between 24-30 weeks while 32 (42.1% diagnosed in the gestational age of 31-35 weeks (late-onset. Pregnancy-induced hypertension 5 (26.3%, polyhydramnios 5 (26.3% and insulin treat-ment 13 (68.4% were higher in women with earlier GDM diagnosis (p<0.05. APGAR score at 5-min below seven was seen in 3 (15.8%, large for gestational age in 5 (26.3%, respiratory distress in 6 (31.5% and pre-term delivery in 5 (26.3% of the early GDM group. These complications were seen more frequently in the early group compared with late-onset GDM group (p<0.05. Conclusion: Earlier diagnosis of GDM was seem to be associated with less favorable newborn outcome.

  5. Academic Culture: A student’s guide

    Directory of Open Access Journals (Sweden)

    Maria Simms

    2006-04-01

    By JEAN BRICK National Centre for English Language Teaching and Research (NCELTR 2006, Sydney, ISBN 978 74138 135 (pbk ISBN 1 74138 135 5 (pbk 263 pages Jean Brick’s book is an excellent guide to academic culture and skills for students and academics alike. Although she describes the book as being about academic culture it is much more than that. I found it to be a comprehensive, useful and very readable guide to English for a variety of academic purposes.

  6. Drug: D10063 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10063 Drug Cenderitide (USAN) C158H263N49O50S3 3742.8706 3745.2721 GLSKGCFGLK LDRI...traction Target-based classification of drugs [BR:br08310] Enzymes Lyases guanylate cyclase A [HSA:4881] [KO:K12323] Cenderitide D100...63 Cenderitide (USAN) guanylate cyclase B [HSA:4882] [KO:K12324] Cenderitide D10063 Cenderitide (USAN) PubChem: 135626783 ...

  7. A Literature Review of the Bacterium Klebsiella spp.: Grays Harbor and Chehalis River Improvements to Navigation Environmental Studies,

    Science.gov (United States)

    1981-04-01

    Taxonomy of Klebsiella pneumoniae isolated from pulp/paper mill wastewater . Environmental Protection Agency, 660/2-75-024. Knittel, M. D. 1975...AD-AI 263 CORPS OF ENGINEERS SEATTLE WASH SEATTLE DISTRICT F/6 13/2 L.ITERATURE REVIEW OF THE BACTERIUM KLEBSIELLA SPP.I BRAYS HAR--ETC(Ul...UNCLASSIFIED N Ehhmmmhhh TA GRAYS HARBOR AND CHEHALIS RIVER IMPROVEMENTS TO NAVIGATIO ENVIRONMENTAL STUDIES A LITERATURE REVIEW OF THE BACTERIUM KLEBSIELLA SPP

  8. A New Video Coding Method Based on Improving Detail Regions

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Moving Pictures Expert Group (MPEG) and H.263 standard coding method is widely used in video compression. However, the visual quality of detail regions such as eyes and mouth is not content in people at the decoder, as far as the conference telephone or videophone is concerned. A new coding method based on improving detail regions is presented in this paper. Experimental results show that this method can improve the visual quality at the decoder.

  9. Optimization of Simulation-Based Training Systems: Model Description, Implementation, and Evaluation

    Science.gov (United States)

    1990-06-01

    results for the $3 million FMS ..... ............. .. 263 29. Training-device selection module results for the weapon system trainer ........... .. 264 30...tasks ......... .. 275 34. Dimensions and levels of fidelity for a turret maintenance trainer ............. ... 278 LIST OF FIGURES Figure 1. Example...Taskcs01 for Instructional _______Cue ______ 0__ Fq’o~eturesResponse 1A I Analyze Tasks %Requirements 018 TaskfrFieiy0-m Learning fo ielt asl

  10. 双正交DCT在视频编码中的实现%Implementation of BinDCT in Video Encoding

    Institute of Scientific and Technical Information of China (English)

    霍晋堂; 阳华

    2002-01-01

    采用仅有移位和加法操作的提升步长的双正交DCT变换来实现H.263视频压缩编码中的DCT变换.双正交DCT能快速有效地实现整数到整数的变换,在C6201定点DSP中,双正交DCT的编码速度与DCT相比有很大提高.

  11. AcEST: BP914062 [AcEST

    Lifescience Database Archive (English)

    Full Text Available chr19 scaffold_66, whole genom... 44 0.003 tr|Q9LVQ4|Q9LVQ4_ARATH Myosin heavy chain-like OS=Arabidopsis th... 43 0.009 tr|Q4PS...KAGMEESAKKSLALKNE 263 >tr|Q4PSB2|Q4PSB2_ARATH Putative uncharacterized protein OS=Arabidopsis thaliana GN=At

  12. Remarkable Activation of the Complement System and Aberrant Neuronal Localization of the Membrane Attack Complex in the Brain Tissues of Scrapie-Infected Rodents.

    Science.gov (United States)

    Lv, Yan; Chen, Cao; Zhang, Bao-Yun; Xiao, Kang; Wang, Jing; Chen, Li-Na; Sun, Jing; Gao, Chen; Shi, Qi; Dong, Xiao-Ping

    2015-12-01

    As an integral part of the innate immunity, the complement system has been reported to involve in the pathogenesis of prion diseases (PrD). However, the states of expression and activity of complement proteins in experimental models of scrapie infection are still not fully understood. Herein, the state of complement activation, the presence, and distribution as well as localization of C3 and membrane attack complex (MAC) in the brains of several scrapie-infected rodents were comparatively assessed through various methodologies. Our data illustrated a significant increase in the total complement activity (CH50, U/ml) in several scrapie-infected rodent brains at the terminal stage and a time-dependent upregulation of C1q in 263K-infected hamsters during the incubation period, intimating the sustained and progressive activation of the classical pathway during PrD progression. Confocal microscopy revealed robust activation of C3 and its localization to various central nervous system (CNS) cells with differential morphology in the brain tissues of both 263K-infected hamsters and 139A-infected C57BL/6 mice at disease end stages. Dynamic analyses of MAC in the brains of 263K-infected hamsters and 139A-infected C57BL/6 mice demonstrated remarkably time-dependent deposition during the incubation period, which may highlight a persistently activated terminal complement components. Moreover, immunofluorescent assays (IFAs) showed that MAC-specific signals appeared to overlap with morphologically abnormal neurons rather than proliferative astrocytes or activated microglia throughout the CNS of both 263K-infected hamsters and 139A-infected C57BL/6 mice. Overall, these results indicate that the activation of the complement system and the subsequent localization of the complement components to neurons may be a hallmark during prion infection, which ultimately contribute to the neurodegeneration in PrD.

  13. Rethinking National Security

    Science.gov (United States)

    1990-10-01

    1989. (U 162 .H29 1989) Hanrieder. Wolfram F., ed. Global Peace and Security: Trend# and Challone . Boulder: Westvlew, 1987. (JX 1952 .G0538 1987...41. Haley. P. Iduard. and Jack Merritt. Nuclear Itratefl, &M Cotl. sA hs Lalut. Boulder: Uestview, 19868. (U 263 .1765 1988) Halloran. Bernard F.. ed...press, Stanford University, 1987. (UA 23 .W38934 1987) Weinberg, Alvin Martin, and Jack N. Barkenbus. Stratojlc Defenses adn AM Con New York: Paragon

  14. Department of Defense, General/Flag Officer, Worldwide Roster

    Science.gov (United States)

    1998-06-01

    USN 9707 970627 3 GENERAL/FLAG OFFICER WORLDWIDE ROSTER DATE DATE OF DUTY TITLE NAME RANK SERVICE ASSIGNED RANK DEP DIR J-8 CARTWRIGHT JAMES E BG* USMC...SIGNAL BRIGADE - SPARTANBURG,SC COMMANDER (RC) SIMPSON DARWIN H BG ARNG 9603 970303 263RD AIR DEFENSE ARTILLERY BRIGADE - ANDERSON,SC COMMANDER (RC...N ................. 27 CARSKADON BRUCE M ................. 28 CARTWRIGHT JAMES E ................ 04 CASCIANO JOHN P ................... 27 CASE

  15. Socioeconomic status as determinant of risk factors for overweight in adolescents

    OpenAIRE

    Fernandes, Rômulo Araújo; Christofaro,Diego Giulliano Destro; Cardoso, Jefferson Rosa; Ronque,Enio Ricardo Vaz; Freitas Júnior,Ismael Forte; Kawaguti, Sandra Satie; Moraes,Augusto César Ferreira de; Oliveira,Arli Ramos de

    2011-01-01

    OBJECTIVES: To analyze risk factors for overweight among adolescents grouped in three different socioeconomic levels. METHODS: This cross-sectional study included 1779 adolescents aged 11 to 17 years, grouped according to socioeconomic status (low, middle, and high). Parents reported their own anthropometric data and the adolescents had their anthropometric data taken by trained researchers, and completed three questionnaires. RESULTS: The prevalence of overweight was 16.7%, 23.8%, and 26.3% ...

  16. Dicty_cDB: Contig-U06833-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 ( CZ509053 ) GMW2-63N3a.b1 GMW2 Glycine max genomic, genomic s... 44 5.8 1 ( EE299190 ) SA_RG0_22c06_SP6 Dogfish Shark..... 44 5.8 1 ( EC945442 ) WIN0534.C21_N01 Cab Sauv flower, leaf and root no... 44 5.8 1 ( DV498868 ) Sa_em0_09p16_5prime Dogfish Shark

  17. Running Head: Texas State Children’s Health Insurance Program. Proposed Solutions for the Continuance of the Texas State Children’s Health Insurance Program

    Science.gov (United States)

    2009-04-01

    150 percent of the FPL, they are not subject to what is called an asset test. An asset test is used to figure out the level of countable assets...26.3 billion. The cost for uninsured children who received uncompensated care that year was $3.6 billion (Hadley & Holahan , 2004). Federal Funding...expansion program as well as a stand alone SCHIP program called CHIP (Kaiser State Health Facts [KSHF], http://www.statehealthfacts.org/chfs.jsp?rgn

  18. JPRS Report, Science & Technology, USSR: Chemistry.

    Science.gov (United States)

    2007-11-02

    with 15-40% water were in some cases stabilized with emulsifying agent, such as OP-7, yielding products with a shelf - life of 6-8 months. Two fuels...Ammonia From Nitrogen and Hydrogen Under Influence of Catalysts Based on Potassium Salts of Transition Metal Carbonyl Hydrides and Metallic Potassium ...Dissolution of Argon in Tetraethylammonium Iodide Solutions in 1,2-Ethanediol at 263-343 K (D.P. Kuz’min, G.A. Krestov; IZVESTIYA VYSSHIKH UCHEBNYKH

  19. Benchmark Design and Installation: A synthesis of Existing Information.

    Science.gov (United States)

    1987-07-01

    U.S. CUSTOMARY TO METRIC (SI) UNITS OF MEASUREMENT These conversion factors include all the significant digits given in the conversion tables in the...structures Table 85 Splks, nails Tables 2,63 T9. 0 1 - In trees, posts, poles Fig. 39 0 - In roads, pavements Fig. 39, Table 33 0 libro than 10 ft dee... Digital data base maps Reinforced con- crete (Fig. B5) Geodetic surveys Same as digital See detail data base maps below monumentat ion . . : ** No

  20. Medical Surveillance Monthly Report (MSMR). Volume 18, Number 07, July 2011

    Science.gov (United States)

    2011-07-01

    syndromes 342 7.1 2.3 109 704 Diseases hair & follicles 263 23.4 5.8 65 794 Nonspec abn reslts fctn study 478 10.0 2.3 108 473 Chronic sinusitis 327 29.1...their duties. Interventions should be targeted to those at high occupational risk; in the U.S. military, these groups include service members in

  1. Notice of Modification

    Institute of Scientific and Technical Information of China (English)

    Dapeng Yang

    2010-01-01

    @@ Dear readers, In the paper "An Anthropomorphic Robot Hand Developed Based on Underactuated Mechanism and Controlled by EMG Signals", Journal of Bionic Engineering, 2009, 6, 255-263, by Dapeng Yang et al., we adopted an experi-mental method already developed by the DLR (German Aerospace Center). Unfortunately, we did not cite their main works properly at that time. We sincerely apologize for this mistake to Dr. Cas'tellini, Dr. van der Smagt and other coauthors.

  2. OM85. Basic Properties of Optical Materials Summaries of Papers.

    Science.gov (United States)

    1985-05-01

    Optical Properties of Solids (Academic, New York, 1972) Ch.3. 7. D.B. Tanner, A.J...12, (1973). 6. T. Fleisch and R. Abermann, Thin Solid FilffF-42, 255-263 (1977). 7. F. Wooten, Optical Properties of Solids (Academic Press, New York...resolve cp structure. Such mea- surements are still lacking for many common semiconducting materials. REFERENCES 1. D.E. Aspnes, in Optical Properties of Solids :

  3. Effects of Trade Restrictions on Imports of Steel.

    Science.gov (United States)

    1980-11-01

    tfiki.i l ittipi i art to ik ri i hi t In part btcatse tiC thfe ii icts oIi ctitsuimite latas . domtiestic kictitlind tesponds toi ittiil ksl Iss - os m...410 Pp Man 1960 PP 292 ADl A08, CAO, Th...n. Ai. Jamas A, "Tihe Trateport Propotioen pp 263 of Itiierv Goo Mixltes to Applied Me~ elt Robitnson. Kathy

  4. Reducing the Cognitive Workload While Operating in Complex Sensory Environments

    Science.gov (United States)

    2007-11-02

    1998), video surveillance and monitoring (Lipton et al., 1998b), and analysis of video streams obtained from airborne observers ( Cohen and Medioni, 1998...networks in real-time car detection and tracking applications. Pattern Recognition Letters, 17:335–343. Cohen , I. and Medioni, G. (1998). Detection and...Object recognition based on human saccadic behaviour. Pattern Analysis and Applications, 2:251–263. Koller, D., Daniilidis, K., and Nagel , H.-H. (1993a

  5. Drug: D02830 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02830 Drug Alovudine (USAN/INN) C10H13FN2O4 244.0859 244.2196 D02830.gif Antiviral...526-93-6 PubChem: 17396987 LigandBox: D02830 NIKKAJI: J263.916E ATOM 17 1 C1y C 23.2400 -23.3100 2 O2x O 22.

  6. Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects.

    Science.gov (United States)

    Daly, Adrian F; Yuan, Bo; Fina, Frederic; Caberg, Jean-Hubert; Trivellin, Giampaolo; Rostomyan, Liliya; de Herder, Wouter W; Naves, Luciana A; Metzger, Daniel; Cuny, Thomas; Rabl, Wolfgang; Shah, Nalini; Jaffrain-Rea, Marie-Lise; Zatelli, Maria Chiara; Faucz, Fabio R; Castermans, Emilie; Nanni-Metellus, Isabelle; Lodish, Maya; Muhammad, Ammar; Palmeira, Leonor; Potorac, Iulia; Mantovani, Giovanna; Neggers, Sebastian J; Klein, Marc; Barlier, Anne; Liu, Pengfei; Ouafik, L'Houcine; Bours, Vincent; Lupski, James R; Stratakis, Constantine A; Beckers, Albert

    2016-04-01

    Somatic mosaicism has been implicated as a causative mechanism in a number of genetic and genomic disorders. X-linked acrogigantism (XLAG) syndrome is a recently characterized genomic form of pediatric gigantism due to aggressive pituitary tumors that is caused by submicroscopic chromosome Xq26.3 duplications that include GPR101 We studied XLAG syndrome patients (n= 18) to determine if somatic mosaicism contributed to the genomic pathophysiology. Eighteen subjects with XLAG syndrome caused by Xq26.3 duplications were identified using high-definition array comparative genomic hybridization (HD-aCGH). We noted that males with XLAG had a decreased log2ratio (LR) compared with expected values, suggesting potential mosaicism, whereas females showed no such decrease. Compared with familial male XLAG cases, sporadic males had more marked evidence for mosaicism, with levels of Xq26.3 duplication between 16.1 and 53.8%. These characteristics were replicated using a novel, personalized breakpoint junction-specific quantification droplet digital polymerase chain reaction (ddPCR) technique. Using a separate ddPCR technique, we studied the feasibility of identifying XLAG syndrome cases in a distinct patient population of 64 unrelated subjects with acromegaly/gigantism, and identified one female gigantism patient who had had increased copy number variation (CNV) threshold for GPR101 that was subsequently diagnosed as having XLAG syndrome on HD-aCGH. Employing a combination of HD-aCGH and novel ddPCR approaches, we have demonstrated, for the first time, that XLAG syndrome can be caused by variable degrees of somatic mosaicism for duplications at chromosome Xq26.3. Somatic mosaicism was shown to occur in sporadic males but not in females with XLAG syndrome, although the clinical characteristics of the disease were similarly severe in both sexes.

  7. The Existence of Smooth Densities for the Prediction, Filtering and Smoothing Problems

    Science.gov (United States)

    1990-12-20

    d’une equation differentielle stochastique avec semi-martingale directrice discontinue, Sem. dc Probabilit~s XIX. Lecture notes in Math. 1123...Proceedings of Internatiional Coinference. Kyoto. 1976 Wiley. 1978, 195-263. (1l] 1P A Meyer, Hlot d’une equation differentielle stochaistiquc...smoothing and, prediction problems. Stochastic flows are also used to derive minimum principles in stochastic control, and new equations for the

  8. Abdominal obesity has the highest impact on metabolic profile in an overweight African population

    DEFF Research Database (Denmark)

    Handlos, L. N.; Witte, D. R.; Mwaniki, D. L.

    2012-01-01

    ), abdominal subcutaneous adipose tissue, arm fat area and arm muscle area) separately as independent variables were carried out. Results: Mean age of study participants was 42.1 years (SD = 9.6) and 26.5% of the participants were men. The median BMI was 28.6 kg/m2 (Q1 = 26.3; Q3 = 31.3). Of the six...

  9. Estimating Instantaneous Energetic Cost During Gait Adaptation

    Science.gov (United States)

    2014-08-31

    ViaSys, IL, USA) 85   and all walking was performed on an instrumented treadmill (FIT, Bertec Corporation, MA, USA). To 86   habituate subjects to...subjects’ preferred step frequency at each speed, defined as the average step frequency during the 95   final 3-minutes of walking in the habituation ...different prosthetic 413   components. Gait & Posture 16: 255–263, 2002. 414   26. Simon D. Kalman filtering. Embedded Systems Programming 14: 72–79, 2001

  10. Broad Detection Range Rhenium Diselenide Photodetector Enhanced by (3-Aminopropyl)Triethoxysilane and Triphenylphosphine Treatment.

    Science.gov (United States)

    Jo, Seo-Hyeon; Park, Hyung-Youl; Kang, Dong-Ho; Shim, Jaewoo; Jeon, Jaeho; Choi, Seunghyuk; Kim, Minwoo; Park, Yongkook; Lee, Jaehyeong; Song, Young Jae; Lee, Sungjoo; Park, Jin-Hong

    2016-08-01

    The effects of triphenylphosphine and (3-aminopropyl)triethoxysilane on a rhenium diselenide (ReSe2 ) photodetector are systematically studied by comparing with conventional MoS2 devices. This study demonstrates a very high performance ReSe2 photodetector with high photoresponsivity (1.18 × 10(6) A W(-1) ), fast photoswitching speed (rising/decaying time: 58/263 ms), and broad photodetection range (possible above 1064 nm).

  11. Survivability Using Controlled Security Services

    Science.gov (United States)

    2005-06-01

    still on-going, while others (Entrust and Rainbow) terminated because of the worsened economy in early 2001. Both Verisign and Microsoft were happy to...CRYPTO 89, Lecture Notes in Computer Science, vol. 435, Springer, Berlin, 1990, pp. 263–277. [15] E. Sperner, Ein satz uber untermenge einer endlichen...Communications of the ACM, 21(2):120--126, 1978. [13] E. Sperner. Ein satz uber untermenge einer endlichen menge. Math Z., 27, pages 544--548, 1928. 139

  12. Statutory Interpretation: General Principles and Recent Trends

    Science.gov (United States)

    2006-03-30

    278 U.S. 41, 48 (1928) (Justice Holmes for Court). 14 Karl Llewellyn, Remarks on the Theory of Appellate Decision and the Rules or Canons About How...Statutes Are To Be Construed, 3 VAND. L. REV. 395 (1950). 15 Landgraf v. USI Film Products, 511 U.S. 244, 263-64 (1994) (traditional presumption against...when application would be tantamount to a formalistic disregard of congressional intent.”12 Canons of construction are basically context-dependent

  13. Preparation and Characterization of the Binary Group 13 Azides M(N3)3 and M(N3)3’CH3CN (M = Ga, In, TI), [Ga(N3)5](2-), and [M(N3)6](3-) (M = In, TI) (Preprint)

    Science.gov (United States)

    2011-05-24

    semiconductor and optoelectronic applications. Although most of these efforts were devoted to gallium azides, aluminium and indium azides were also...their usefulness for semiconductor and optoelectronic applications. Although most of these efforts were devoted to gallium azides,[20,21] aluminium and...4253 -1471 44 H(22) 3736 3825 -1326 52 H(23) 4209 3248 -466 58 H(24) 3087 3112 263 54 H(26) 3906 4945 5420 37 H(27) 5618 5178 5700 46 H(28) 6061

  14. Antifreeze protein modulates cell survival during cryopreservation: mediation through influence on ice crystal growth.

    OpenAIRE

    Carpenter, J F; Hansen, T N

    1992-01-01

    Antifreeze proteins (AFPs) are extremely efficient at inhibiting ice recrystallization in frozen solutions. Knight and Duman [Knight, C. A. & Duman, J. G. (1986) Cryobiology 23, 256-263] have proposed that this may be an important function of the proteins in freeze-tolerant organisms. We have tested this proposal in vitro by characterizing the influence of AFP on the recovery of cryopreserved cells, which often can survive cooling and yet subsequently be damaged by ice crystal growth during w...

  15. Responses to Gamma-Aminobutyric Acid of Rat Visual Cortical Neurons in Tissue Slices

    Science.gov (United States)

    1986-04-01

    Neurol. 234: 242-263. Peters, A. and Proskauer, c. C. (1980) Synaptic relationships between a multipolar stellate cell and a pyramidal neuron in rat...APR 1986 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Responses to Gamma-Aminobutyric Acid of Rat Visual Cortical Neurons in...AIR FORCE MEDICAL CENTER Title of Thesis: Responses to Gamma-Aminobutyric Acid of Rat Visual Cortical Neurons in Tissue Slices Name of Candidate

  16. Methodological Considerations in the Design of Large Scale Systems Engineering Processes.

    Science.gov (United States)

    1981-02-01

    Tversky, A., "Prospect Theory : An Analysis of Decision Under Risk", Econometrica, vol. 47, March 1979, pp. 263-291. Inhelder, B. and Piaget , J., The...concerned with the mathematical and behavioral theory of systems. This we will call systems science and operations research. Also, it says that we...will be con- cerned with a combination of these theories . We will denote the effort to obtain this combination systems methodology and design. Finally

  17. The study of the character strengths in children: Relations with the psychological well-being, social desirability and personality

    OpenAIRE

    Aldana Sol Grinhauz

    2015-01-01

    This study aimed to verify the existence of associations between character strengths, psychological welfare, social desirability and personality in children of 10 to12 years old. 518 children (254 boys and 263 girls) between 10 and 12 years old and attending public and private schools in the City of Buenos Aires (Argentina) participated on this study. The following were administered: a socio–demographic survey; a survey to assess the PERMA ́s access to welfare theory five elements, the Virtue...

  18. Human Eating Behavior: Preferences. Consumption Patterns, and Biorhythms

    Science.gov (United States)

    1978-06-01

    fMCDC) CWD(DD(DD(ZD(D 145 Frijole Salad C) Q )(DDZaD (I)DDCD aCD)XQ®DCDDCD® 146 Burritos C) C)DM MZ M (DC)CD WDC)DCX )MWMMMZCD 147 Chocolate Cookies C) C...Hominy Grits 263 Cucumber & Onion Salad 192 ID NAME 46 Caesar Dressing 149 Rice Pilaf 351 Minestrone Soup 145 Frijole Salad 271 Pork Hocks 210

  19. Beliefs about Thought Probability: Evidence for Persistent Errors in Mindreading and Links to Executive Control

    Science.gov (United States)

    Lagattuta, Kristin Hansen; Sayfan, Liat; Harvey, Christina

    2014-01-01

    Four- to 10-year-olds' and adults' (N = 263) ability to inhibit privileged knowledge and simulate a naïve perspective were examined. Participants viewed pictures that were then occluded aside from a small ambiguous part. They offered suggestions for how a naïve person might interpret the hidden pictures, as well as rated the probability…

  20. Drug: D02122 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ics for external use D02122 Tetracycline hydrochloride (JP16/USP) 27 Dental preparations 276 Antibiotics... 2760 Antibiotics D02122 Tetracycline hydrochloride (JP16/USP) 6 Agents against patholo...gic organisms and parasites 61 Antibiotics 615 Acting mainly on gram-positive bac...) S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics S01AA09 Tetracycline D02122 T...02122 Tetracycline hydrochloride (JP16/USP) 26 Epidermides 263 Suppurative dermatosis agents 2634 Antibiot