WorldWideScience

Sample records for bohrium 262

  1. From bohrium to copernicium and beyond SHE research at SHIP

    Science.gov (United States)

    Münzenberg, G.

    2015-12-01

    Heavy-element research with SHIP at GSI is reviewed including the discovery of the chemical elements bohrium to copernicium, experimental developments, cold fusion of heavy ions, and the discovery of a shell region around hassium. Elements bohrium and heavier are located beyond the limit of liquid-drop stability. They exist by shell stabilization. A universal, sensitive, and fast method: in-flight separation and identification of single atomic nuclei has been developed with the velocity filter SHIP and the detector system to measure decay sequences of individual atoms. Research with single atomic nuclei including detection methods, identification, and physics results will be discussed. Experiments with actinide targets as well as prospects with NUSTAR at FAIR will be addressed.

  2. 40 CFR 262.30 - Packaging.

    Science.gov (United States)

    2010-07-01

    ... under 49 CFR parts 173, 178, and 179. ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Packaging. 262.30 Section 262.30... APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Pre-Transport Requirements § 262.30 Packaging....

  3. 39 CFR 262.3 - Information.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Information. 262.3 Section 262.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT DEFINITIONS § 262.3 Information. Data combined with the knowledge of its context and having the potential...

  4. 40 CFR 262.207 - Training.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Training. 262.207 Section 262.207... Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.207 Training. An eligible academic entity must provide training to all individuals working in a laboratory at the...

  5. 49 CFR 262.11 - Application process.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Application process. 262.11 Section 262.11 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... IMPROVEMENT PROJECTS § 262.11 Application process. (a) All grant applications for opportunities funded...

  6. 39 CFR 262.5 - Systems (Privacy).

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Systems (Privacy). 262.5 Section 262.5 Postal... DEFINITIONS § 262.5 Systems (Privacy). (a) Privacy Act system of records. A Postal Service system containing... individual. (c) Computer matching program. A “matching program,” as defined in the Privacy Act, 5 U.S.C....

  7. 40 CFR 262.70 - Farmers.

    Science.gov (United States)

    2010-07-01

    ... or other standards in 40 CFR parts 264, 265, 268, or 270 for those wastes provided he triple rinses... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Farmers. 262.70 Section 262.70... APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Farmers § 262.70 Farmers. A farmer disposing of waste...

  8. 40 CFR 262.80 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Applicability. 262.80 Section 262.80 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS... the OECD § 262.80 Applicability. (a) The requirements of this subpart apply to imports and exports...

  9. 40 CFR 262.81 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Definitions. 262.81 Section 262.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS... the OECD § 262.81 Definitions. The following definitions apply to this subpart. (a)...

  10. 40 CFR 262.85 - Contracts.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Contracts. 262.85 Section 262.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS... the OECD § 262.85 Contracts. (a) Transfrontier movements of hazardous wastes subject to amber or...

  11. 40 CFR 262.84 - Tracking document.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Tracking document. 262.84 Section 262.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... Recovery within the OECD § 262.84 Tracking document. (a) All U.S. parties subject to the...

  12. 40 CFR 262.82 - General conditions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false General conditions. 262.82 Section 262.82 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... Recovery within the OECD § 262.82 General conditions. (a) Scope. The level of control for exports...

  13. 49 CFR 195.262 - Pumping equipment.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pumping equipment. 195.262 Section 195.262... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... warn of the presence of hazardous vapors in the pumping station building. (b) The following must...

  14. 42 CFR 422.262 - Beneficiary premiums.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Beneficiary premiums. 422.262 Section 422.262... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Submission of Bids, Premiums, and Related Information and Plan Approval § 422.262 Beneficiary premiums. (a) Determination of MA monthly basic...

  15. Dicty_cDB: SLA262 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA262 (Link to dictyBase) - - - Contig-U16382-1 SLA262Z (Link... to Original site) - - SLA262Z 733 - - - - Show SLA262 Library SL (Link to library) Clone ID SLA262 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA2-C/SLA262Q.Seq.d/ Representative seq. ID SLA26...2Z (Link to Original site) Representative DNA sequence >SLA262 (SLA262Q) /CSM/SL/SLA2-C/SLA262Q.Seq.d/ XXXXX...AACAATTAATAAATATGTTGTATT TTATTTAAACTTATATTATAAAA sequence update 1997. 6. 5 Translated Amino Acid sequence -

  16. 25 CFR 262.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Definitions. 262.2 Section 262.2 Indians BUREAU OF INDIAN... Definitions. As used for purposes of this part: (a) Funerary objects means objects that, as a part of the death rite or ceremony of a culture, are reasonably believed to have been placed with human remains...

  17. 37 CFR 262.1 - General.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false General. 262.1 Section 262.1 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY...), during the period 2003-2004 and in the case of Subscription Services 1998-2004 (the “License Period”)....

  18. 40 CFR 262.43 - Additional reporting.

    Science.gov (United States)

    2010-07-01

    ... require generators to furnish additional reports concerning the quantities and disposition of wastes identified or listed in 40 CFR part 261. ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.43...

  19. 40 CFR 262.50 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... the transportation, treatment, storage and disposal of hazardous waste for shipments between the... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.50 Applicability. This...

  20. Dicty_cDB: CFE262 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF (Link to library) CFE262 (Link to dictyBase) - - - Contig-U16368-1 CFE262P (Link... to Original site) CFE262F 652 CFE262Z 401 CFE262P 1053 - - Show CFE262 Library CF (Link to library) Clone ID CFE262 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16368-1 Original site URL http://dict...HRPPPRPPVDQCRNQHCPHGYSC RVIKGCATCVRDARPPHNLCRGFGCPEGSHCEVLEKHPVCVRNHVPPHPPPPPQICGSVN CGPGYICTIINGHPTCIRGDGYL...VNEHGKCRCVPHRPPPRPPVDQCRNQHCPHGYSC RVIKGCATCVRDARPPHNLCRGFGCPEGSHCEVLEKHPVCVRNHVPPHPPPPPQICGSVN CGPGYICTIING

  1. Properties of an $\\alpha$ particle in a Bohrium $270$ Nucleus under the Generalized Symmetric Woods-Saxon Potential

    CERN Document Server

    Lütfüoğlu, B C

    2016-01-01

    The energy eigenvalues and the wave functions of an $\\alpha$ particle in a Bohrium $270$ nucleus were calculated by solving Schr\\"odinger equation for Generalized Symmetric Woods-Saxon potential. Using the energy spectrum by excluding and including the quasi-bound eigenvalues, entropy, internal energy, Helmholtz energy, and specific heat, as functions of reduced temperature were calculated. Stability and emission characteristics are interpreted in terms of the wave and thermodynamic functions. The kinetic energy of a decayed $\\alpha$ particle was calculated using the quasi-bound states, which is found close to the experimental value.

  2. 21 CFR 26.2 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN... Provisions for Pharmaceutical Good Manufacturing Practices § 26.2 Purpose. The provisions of this subpart... official good manufacturing practices (GMP's) inspection reports after a transitional period aimed...

  3. 49 CFR 262.15 - Environmental assessment.

    Science.gov (United States)

    2010-10-01

    ... Environmental Quality (40 CFR part 1500) and the Advisory Council on Historic Preservation Protection of Historic Properties regulation (36 CFR part 800) will govern FRA's compliance with applicable environmental... 49 Transportation 4 2010-10-01 2010-10-01 false Environmental assessment. 262.15 Section...

  4. 37 CFR 262.5 - Confidential information.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Confidential information. 262... information. (a) Definition. For purposes of this part, “Confidential Information” shall include the statements of account, any information contained therein, including the amount of royalty payments, and...

  5. 40 CFR 262.51 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... waste in accordance with 40 CFR part 262, subpart B, or equivalent State provision, which specifies a treatment, storage, or disposal facility in a receiving country as the facility to which the hazardous waste... to which a hazardous waste is sent for the purpose of treatment, storage or disposal (except...

  6. 40 CFR 262.22 - Number of copies.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Number of copies. 262.22 Section 262...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE The Manifest § 262.22 Number of copies. The manifest consists of at least the number of copies which will provide the generator, each transporter, and the...

  7. 49 CFR 262.17 - Combining grant awards.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Combining grant awards. 262.17 Section 262.17... IMPROVEMENT PROJECTS § 262.17 Combining grant awards. Two or more States, but not political subdivisions of States, may, pursuant to an agreement entered into by the States, combine any part of the...

  8. 40 CFR 262.83 - Notification and consent.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Notification and consent. 262.83 Section 262.83 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... for Recovery within the OECD § 262.83 Notification and consent. (a) Applicability. Consent must...

  9. 40 CFR 262.89 - OECD Waste Lists.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false OECD Waste Lists. 262.89 Section 262.89 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED... Recovery within the OECD § 262.89 OECD Waste Lists. (a) General. For the purposes of this Subpart, a...

  10. 40 CFR 262.86 - Provisions relating to recognized traders.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Provisions relating to recognized traders. 262.86 Section 262.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... Hazardous Waste for Recovery within the OECD § 262.86 Provisions relating to recognized traders. (a)...

  11. 40 CFR 262.87 - Reporting and recordkeeping.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Reporting and recordkeeping. 262.87 Section 262.87 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... for Recovery within the OECD § 262.87 Reporting and recordkeeping. (a) Annual reports. For all...

  12. 40 CFR 262.60 - Imports of hazardous waste.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Imports of hazardous waste. 262.60 Section 262.60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Imports of Hazardous Waste § 262.60...

  13. 31 CFR 26.2 - Availability of project listings.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Availability of project listings. 26.2 Section 26.2 Money and Finance: Treasury Office of the Secretary of the Treasury ENVIRONMENTAL...-8191, not a toll-free call). (2) If a copy is not available from the BIC, members of the public...

  14. 36 CFR 262.11 - Impounding of dogs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Impounding of dogs. 262.11... ENFORCEMENT SUPPORT ACTIVITIES Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National Forest System, which has been closed to dogs running at large, may...

  15. 40 CFR 262.108 - When will this subpart expire?

    Science.gov (United States)

    2010-07-01

    ... Section 262.108 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.108 When will this subpart expire? This subpart...

  16. Integral Field Spectroscopy of HH 262: The Spectral Atlas

    CERN Document Server

    López, R; Sánchez, S F; Gómez, G; Estalella, R; Riera, A

    2008-01-01

    HH 262 is a group of emitting knots displaying an "hour-glass" morphology in the Halpha and [SII] lines, located 3.5' to the northeast of the young stellar object L1551-IRS5, in Taurus. We present new results of the kinematics and physical conditions of HH 262 based on Integral Field Spectroscopy covering a field of 1.5'x3', which includes all the bright knots in HH 262. These data show complex kinematics and significant variations in physical conditions over the mapped region of HH 262 on a spatial scale of <3". A new result derived from the IFS data is the weakness of the [NII] emission (below detection limit in most of the mapped region of HH 262), including the brightest central knots. Our data reinforce the association of HH 262 with the redshifted lobe of the evolved molecular outflow L1551-IRS5. The interaction of this outflow with a younger one, powered by L1551 NE, around the position of HH 262 could give rise to the complex morphology and kinematics of HH 262.

  17. 27 CFR 28.262 - Delay in lading at port.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Delay in lading at port..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Proceedings at Ports of Export § 28.262 Delay in lading at port. If, on arrival of a shipment withdrawn for export without payment of tax or free of...

  18. 40 CFR 98.262 - GHGs to report.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Phosphoric Acid Production § 98.262 GHGs to report. (a) You must report CO2 process emissions from each wet-process phosphoric acid process line. (b) You must report under subpart C of...

  19. 40 CFR 262.213 - Laboratory clean-outs.

    Science.gov (United States)

    2010-07-01

    ... product (listed in 40 CFR part 261, subpart D or exhibiting one or more characteristics in 40 CFR part 261... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Laboratory clean-outs. 262.213 Section....213 Laboratory clean-outs. (a) One time per 12 month period for each laboratory, an eligible...

  20. 40 CFR 262.101 - What is in this subpart?

    Science.gov (United States)

    2010-07-01

    ...-Laboratory Environmental Management Standard § 262.101 What is in this subpart? This subpart provides a framework for a new management system for wastes that are generated in University laboratories. This framework is called the Laboratory Environmental Management Standard. The standard includes some...

  1. 38 CFR 3.262 - Evaluation of income.

    Science.gov (United States)

    2010-07-01

    ... restricted lands as defined in 25 CFR 151.2. (January 1, 1994) (Authority: Sec. 13736, Pub. L. 103-66; 107...)(6)) Editorial Note: For Federal Register citations affecting § 3.262, see the List of CFR Sections...), Program for Local Services (PLS), ACTION Cooperative Volunteers (ACV), Foster Grandparent Program...

  2. 45 CFR 262.0 - What definitions apply to this part?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What definitions apply to this part? 262.0 Section 262.0 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES ACCOUNTABILITY PROVISIONS-GENERAL § 262.0...

  3. 27 CFR 25.262 - Restrictions and conditions on processes of concentration and reconstitution.

    Science.gov (United States)

    2010-04-01

    ... conditions on processes of concentration and reconstitution. 25.262 Section 25.262 Alcohol, Tobacco Products... Concentrate § 25.262 Restrictions and conditions on processes of concentration and reconstitution. (a) Conditions on concentration. A brewer may not employ any process of concentration which separates...

  4. 40 CFR 262.88 - Pre-approval for U.S. Recovery Facilities. [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Pre-approval for U.S. Recovery Facilities. 262.88 Section 262.88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... Hazardous Waste for Recovery within the OECD § 262.88 Pre-approval for U.S. Recovery Facilities....

  5. 40 CFR 262.106 - When must a hazardous waste determination be made?

    Science.gov (United States)

    2010-07-01

    ... determination be made? 262.106 Section 262.106 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.106 When must a hazardous...

  6. 40 CFR 262.107 - Under what circumstances will a university's participation in this environmental management...

    Science.gov (United States)

    2010-07-01

    ... university's participation in this environmental management standard pilot be terminated? 262.107 Section 262... Environmental Management Standard § 262.107 Under what circumstances will a university's participation in this environmental management standard pilot be terminated? (a) EPA retains the right to terminate a......

  7. 40 CFR 262.100 - To what organizations does this subpart apply?

    Science.gov (United States)

    2010-07-01

    ... subpart apply? 262.100 Section 262.100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE University Laboratories XL Project-Laboratory Environmental Management Standard § 262.100 To what organizations does...

  8. 29 CFR 779.262 - Excise taxes at the retail level.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Excise taxes at the retail level. 779.262 Section 779.262... Coverage Excise Taxes § 779.262 Excise taxes at the retail level. (a) Federal excise taxes are imposed at the retail level on highway vehicle fuels other than gasoline under the provisions of 26 U.S.C....

  9. The Beta Problem A Study of Abell 262

    CERN Document Server

    Neill, J D; Craig, W W; Hailey, C J; Misch, A A; Neill, James D.; Brodie, Jean P.; Craig, William W.; Hailey, Charles J.; Misch, Anthony A.

    2001-01-01

    We present an investigation of the dynamical state of the cluster A262. Existing optical line of sight velocities for select cluster galaxies have been augmented by new data obtained with the Automated Multi-Object Spectrograph at Lick Observatory. We find evidence for a virialized early-type population distinct from a late-type population infalling from the Pisces-Perseus supercluster ridge. We also report on a tertiary population of low luminosity galaxies whose velocity dispersion distinguishes them from both the early and late-type galaxies. We supplement our investigation with an analysis of archival X-ray data. A temperature is determined using ASCA GIS data and a gas profile is derived from ROSAT HRI data. The increased statistics of our sample results in a picture of A262 with significant differences from earlier work. A previously proposed solution to the "beta-problem" in A262 in which the gas temperature is significantly higher than the galaxy temperature is shown to result from using too low a vel...

  10. Analysis of cause of 262 dwarfism%儿童矮小262例病因分析

    Institute of Scientific and Technical Information of China (English)

    王晓宁

    2005-01-01

    目的探讨本地区儿童矮小的病因及干预.方法回顾性分析262例身高儿童矮小的身高、骨龄、生长激素水平、甲状腺功能及微量元素等指标.结果 262例儿童矮小中,内分泌异常所致的矮小占首位(38.55%,101/262),其中生长激素缺乏性矮小(GHD)38例,性早熟22例;体质延迟性矮小67例,男女发病比例为2.75;遗传性矮小35例;特发性矮小33例.67例体质延迟性矮小患儿的病因:食欲不振41例,睡眠不足29例,活动过多23例,微量元素缺乏36例.结论内分泌异常仍然是矮小的主要原因.

  11. Anthracycline metabolites from Streptomyces violaceus A262. I. Isolation of antibiotic-blocked mutants from Streptomyces violaceus A262.

    Science.gov (United States)

    Johdo, O; Ishikura, T; Yoshimoto, A; Takeuchi, T

    1991-10-01

    Five mutant (or variant) strains producing new anthracycline antibiotics were derived from Streptomyces violaceus A262 by mutagenesis treatment. Strain SE1-625 showed a limited production of three known beta-rhodomycinone diglycosides while the parent strain produced numerous unidentified beta-rhodomycinone glycosides. Strain SU2-730 was an antibiotic-blocked mutant which produced only epsilon-rhodomycinone glycosides (named epelmycins). Strains SC-7 and SE2-2385 were variants which produced alpha-citromycinone glycosides (named yellamycins) and beta-isorhodomycinone glycosides (named obelmycins), respectively. Strain SE2-2385-A1 produced alpha 2-rhodomycinone glycosides (named alldimycins). Glycosidation-less mutants which accumulated only aglycone were also obtained. Isolation of these mutants or variants and preliminary identification of their anthracycline products are described. PMID:1955394

  12. 40 CFR 262.206 - Labeling and management standards for containers of unwanted material in the laboratory.

    Science.gov (United States)

    2010-07-01

    ... Material for Laboratories Owned by Eligible Academic Entities § 262.206 Labeling and management standards... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Labeling and management standards for containers of unwanted material in the laboratory. 262.206 Section 262.206 Protection of...

  13. Endometrial carcinoma: stage I. A retrospective analysis of 262 patients.

    Science.gov (United States)

    De Palo, G; Kenda, R; Andreola, S; Luciani, L; Musumeci, R; Rilke, F

    1982-08-01

    From 1969 to 1977, 420 patients with endometrial carcinoma were observed and treated at the National Tumor Institute of Milan. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed in 351. After careful clinical and pathologic review, 262 patients were classified as having stage I disease. Further treatment included post-operative radium therapy to the vaginal vault. There were 247 cases with adenocarcinoma, 10 with adenoacanthoma, and 5 with adenosquamous or clear cell carcinoma. Of 257 cases with adenocarcinoma or adenoacanthoma, 63 were grade 1, 161 grade 2, and 33 grade 3. Of the total series, only 41 cases had disease limited to the mucosal surface. The 5-year actuarial survival was 91.4% and the recurrence-free survival was 93.4%. The case material was evaluated according to the risk factors, and results were 1) premenopausal patients had a better prognosis (100% recurrence-free survival versus 92.8% for postmenopausal women, P = .003); 2) length of the uterine cavity was not a significant prognostic factor; 3) myometrial invasion alone was not prognostic but correlated with grade of tumor; 4) the grade of the tumor was an important determinant of recurrence (grade 1 98% recurrence-free survival, grade 2 95%, grade 3 79%). With the described therapy, vaginal recurrences were absent. The recurrences were distant in 20% and local with or without distant metastases in 80%.

  14. 27 CFR 26.262a - Computation of effective tax rate.

    Science.gov (United States)

    2010-04-01

    ... TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.262a Computation of effective tax rate....

  15. 27 CFR 26.262 - Determination of tax on distilled spirits.

    Science.gov (United States)

    2010-04-01

    ... TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Procedure at Port of Entry From the Virgin Islands § 26.262 Determination of tax on...

  16. [Total laparoscopic hysterectomy: retrospective analysis of 262 cases].

    Science.gov (United States)

    Nogueira-Silva, Cristina; Santos-Ribeiro, Samuel; Barata, Sónia; Alho, Conceição; Osório, Filipa; Calhaz-Jorge, Carlos

    2014-01-01

    Introdução: A histerectomia é a cirurgia ginecológica major mais frequentemente realizada nos países desenvolvidos, considerando-se três principais vias de abordagem: vaginal, abdominal e laparoscópica. Apesar de múltiplas vantagens, a histerectomia totalmente laparoscópica tem-se associado a controvérsia relativamente à taxa de complicações.Objectivos: Análise da nossa casuística de histerectomia totalmente laparoscópica e avaliação da taxa de complicações.Material e Métodos: Análise retrospetiva dos processos clínicos das doentes submetidas a histerectomia totalmente laparoscópica no nosso departamento, pela mesma equipa cirúrgica, entre abril de 2009 e março de 2013 (n = 262).Resultados: As doentes tinham em média 48,9 ± 9 anos e 49,2% tinha antecedentes de cirurgia abdomino-pélvica. O índice de massa corporal médio era 26,5 ± 4,5 kg/m2, sendo que 42% eram obesas ou tinham excesso de peso. O tempo operatório médio para realização da histerectomia totalmente laparoscópica foi 77,7 ± 27,5 minutos, diminuindo significativamente com o aumento da experiência da equipa cirúrgica. O peso médio da peça operatória foi 241 ± 168,4g e a duração média do internamento após a cirurgia foi 1,49 ±0,9 dias. A diferença entre a hemoglobina pré e pós-operatória foi 1,5 ± 0,8g/dL. A morbilidade major foi 1,5% (n = 4) e a minor 11,5% (n = 30). Salienta-se um caso de conversão para laparotomia e dois casos de deiscência da cúpula vaginal. Não ocorreu nenhuma lesão urinária ou gastrointestinal grave.Conclusões: Esta série demonstra que, se realizada por uma equipa cirúrgica adequadamente treinada, a histerectomia totalmente laparoscópica é segura e associada a baixa taxa de complicações.

  17. Atomic Mass and NuclearBinding Energy for Uup-262(Ununpentium)

    Science.gov (United States)

    Sukhoruchkin, S. I.; Soroko, Z. N.

    This document is part of the Supplement containing the complete sets of data of Subvolume B `Nuclei with Z = 55 - 100' of Volume 22 `Nuclear Binding Energies and Atomic Masses' of Landolt-Börnstein - Group I `Elementary Particles, Nuclei and Atoms', and additionally including data for nuclei with Z = 101 - 130. It provides atomic mass, mass excess, nuclear binding energy, nucleon separation energies, Q-values, and nucleon residual interaction parameters for atomic nuclei of the isotope Uup-262 (Ununpentium, atomic number Z = 115, mass number A = 262).

  18. 40 CFR 436.262 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Effluent limitations guidelines... technology currently available. 436.262 Section 436.262 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE...

  19. 45 CFR 262.5 - Under what general circumstances will we determine that a State has reasonable cause?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Under what general circumstances will we determine that a State has reasonable cause? 262.5 Section 262.5 Public Welfare Regulations Relating to Public... circumstances will we determine that a State has reasonable cause? (a) We will not impose a penalty against...

  20. 20 CFR 416.262 - Eligibility requirements for special SSI cash benefits.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Eligibility requirements for special SSI cash... Disabling Impairment § 416.262 Eligibility requirements for special SSI cash benefits. You are eligible for special SSI cash benefits if you meet the following requirements— (a) You were eligible to receive...

  1. Catalase C-262T polymorphism and risk of prostate cancer: evidence from meta-analysis.

    Science.gov (United States)

    Hu, Jieping; Feng, Fupeng; Zhu, Shimiao; Sun, Libin; Li, Gang; Jiang, Ning; Shang, Zhiqun; Niu, Yuanjie

    2015-03-10

    Catalase is an important endogenous antioxidant enzyme that detoxifies hydrogen peroxide to oxygen and water, thus limiting the deleterious effects of reactive oxygen species. Several studies investigated the role of the Catalase (CAT) C-262T gene polymorphism on the risk of prostate cancer (PCa), but get conflicting results. We performed a meta-analysis based on five studies, to determine whether Catalase C-262T polymorphism contributes to the risk of prostate cancer using odds ratios (OR) with 95% confidence intervals (CI). On the whole, our evidence indicates that CAT C-262T polymorphism significantly increases PCa risk in the allele comparison model (OR=1.094, 95% CI=1.015-1.178, P=0.018). In the stratified analysis by ethnicity, the same results are found among Caucasians (allele model, OR=1.090, 95% CI=1.009-1.177, P=0.028, dominant model, OR=1.108, 95% CI=1.023-1.201, P=0.012, recessive model, OR=1.379, 95% CI=1.158-1.641, P=0.000, homozygous model, OR=1.429, 95% CI=1.196-1.707, P=0.000, and heterozygote model, OR=1.224, 95% CI=1.020-1.469, P=0.030). In conclusion, this meta-analysis suggests a positive correlation between Catalase C-262T polymorphism and the development of PCa.

  2. 40 CFR 262.103 - What is the scope of the laboratory environmental management standard?

    Science.gov (United States)

    2010-07-01

    ... University Laboratories XL Project-Laboratory Environmental Management Standard § 262.103 What is the scope of the laboratory environmental management standard? The Laboratory Environmental Management Standard... 40 Protection of Environment 25 2010-07-01 2010-07-01 false What is the scope of the...

  3. 40 CFR 262.102 - What special definitions are included in this subpart?

    Science.gov (United States)

    2010-07-01

    ... Laboratories XL Project-Laboratory Environmental Management Standard § 262.102 What special definitions are... Laboratory Waste means a laboratory waste, defined in the Environmental Management Plan as posing significant... Management Plan (EMP) means a written program developed and implemented by the university which sets...

  4. Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

    DEFF Research Database (Denmark)

    Gerlach, Lars Ole; Jakobsen, Janus S; Jensen, Kasper P;

    2003-01-01

    +), Zn(2+), or Ni(2+) into the cyclam rings of the compound. The rank order of the transition metal ions correlated with the calculated binding energy between free acetate and the metal ions coordinated in a cyclam ring. Construction of AMD3100 substituted with only a single Cu(2+) or Ni(2+) ion...... demonstrated that the increase in binding affinity of the metal ion substituted bicyclam is achieved through an enhanced interaction of just one of the ring systems. Mutational analysis of potential metal ion binding residues in the main ligand binding crevice of the CXCR4 receptor showed that although binding...... of the bicyclam is dependent on both Asp(171) and Asp(262), the enhancing effect of the metal ion was selectively eliminated by substitution of Asp(262) located at the extracellular end of TM-VI. It is concluded that the increased binding affinity of the metal ion substituted AMD3100 is obtained through enhanced...

  5. Human catalase gene polymorphism (CAT C-262T) and risk of male infertility.

    Science.gov (United States)

    Sabouhi, S; Salehi, Z; Bahadori, M H; Mahdavi, M

    2015-02-01

    Infertility is the failure of a couple to engender after endeavouring at least one full year of unprotected intercourse. It has been reported that reactive oxygen species contributed to pathogenesis of various disease. To inactivate ROS cells biosynthesise several antioxidant enzymes, one of them is catalase which contributes H2 O2 to H2 O and O2 . This study set out to delineate the association of catalase C-262T polymorphism with idiopathic male infertility. The study included 195 men with idiopathic infertility and 190 healthy volunteers. Genomic DNA was extracted from peripheral blood leucocytes. Genotype and allele frequencies were determined in patients and controls using allele-specific PCR (AS-PCR). The prevalence of genotype frequencies of the CAT CC/CT/TT was 31.79%, 65.12% and 3.07%, respectively, in infertile subjects, as against 24.73%, 55.26% and 20%, respectively, in healthy volunteers. Statistical analysis has emerged significant difference from the comparison of either genotype (P catalase C-262T polymorphism indicates that CAT-262T/T genotype confers less susceptibility to male infertility. Further studies with larger numbers of patients are required for further evaluation and confirmation of our finding.

  6. Corrective Action Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This Corrective Action Plan (CAP) provides selected corrective action alternatives and proposes the closure methodology for Corrective Action Unit (CAU) 262, Area 25 Septic Systems and Underground Discharge Point. CAU 262 is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996. Remediation of CAU 262 is required under the FFACO. CAU 262 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles [mi]) northwest of Las Vegas, Nevada. The nine Corrective Action Sites (CASs) within CAU 262 are located in the Nuclear Rocket Development Station complex. Individual CASs are located in the vicinity of the Reactor Maintenance, Assembly, and Disassembly (R-MAD); Engine Maintenance, Assembly, and Disassembly (E-MAD); and Test Cell C compounds. CAU 262 includes the following CASs as provided in the FFACO (1996); CAS 25-02-06, Underground Storage Tank; CAS 25-04-06, Septic Systems A and B; CAS 25-04-07, Septic System; CAS 25-05-03, Leachfield; CAS 25-05-05, Leachfield; CAS 25-05-06, Leachfield; CAS 25-05-08, Radioactive Leachfield; CAS 25-05-12, Leachfield; and CAS 25-51-01, Dry Well. Figures 2, 3, and 4 show the locations of the R-MAD, the E-MAD, and the Test Cell C CASs, respectively. The facilities within CAU 262 supported nuclear rocket reactor engine testing. Activities associated with the program were performed between 1958 and 1973. However, several other projects used the facilities after 1973. A significant quantity of radioactive and sanitary waste was produced during routine operations. Most of the radioactive waste was managed by disposal in the posted leachfields. Sanitary wastes were disposed in sanitary leachfields. Septic tanks, present at sanitary leachfields (i.e., CAS 25-02-06,2504-06 [Septic Systems A and B], 25-04-07, 25-05-05,25-05-12) allowed solids to settle out of suspension prior to entering the leachfield. Posted leachfields do not contain septic tanks. All CASs located in CAU 262 are

  7. Corrective Action Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    K. B. Campbell

    2002-06-01

    This Corrective Action Plan (CAP) provides selected corrective action alternatives and proposes the closure methodology for Corrective Action Unit (CAU) 262, Area 25 Septic Systems and Underground Discharge Point. CAU 262 is identified in the Federal Facility Agreement and Consent Order (FFACO) of 1996. Remediation of CAU 262 is required under the FFACO. CAU 262 is located in Area 25 of the Nevada Test Site (NTS), approximately 100 kilometers (km) (62 miles [mi]) northwest of Las Vegas, Nevada. The nine Corrective Action Sites (CASs) within CAU 262 are located in the Nuclear Rocket Development Station complex. Individual CASs are located in the vicinity of the Reactor Maintenance, Assembly, and Disassembly (R-MAD); Engine Maintenance, Assembly, and Disassembly (E-MAD); and Test Cell C compounds. CAU 262 includes the following CASs as provided in the FFACO (1996); CAS 25-02-06, Underground Storage Tank; CAS 25-04-06, Septic Systems A and B; CAS 25-04-07, Septic System; CAS 25-05-03, Leachfield; CAS 25-05-05, Leachfield; CAS 25-05-06, Leachfield; CAS 25-05-08, Radioactive Leachfield; CAS 25-05-12, Leachfield; and CAS 25-51-01, Dry Well. Figures 2, 3, and 4 show the locations of the R-MAD, the E-MAD, and the Test Cell C CASs, respectively. The facilities within CAU 262 supported nuclear rocket reactor engine testing. Activities associated with the program were performed between 1958 and 1973. However, several other projects used the facilities after 1973. A significant quantity of radioactive and sanitary waste was produced during routine operations. Most of the radioactive waste was managed by disposal in the posted leachfields. Sanitary wastes were disposed in sanitary leachfields. Septic tanks, present at sanitary leachfields (i.e., CAS 25-02-06,2504-06 [Septic Systems A and B], 25-04-07, 25-05-05,25-05-12) allowed solids to settle out of suspension prior to entering the leachfield. Posted leachfields do not contain septic tanks. All CASs located in CAU 262 are

  8. The X-ray -- radio alignment in the z = 2.2 radio galaxy PKS 1138--262

    CERN Document Server

    Carilli, C L; Pentericci, L; Röttgering, H J A; Miley, G K; Kurk, J D; Van Breugel, W; Breugel, Wil van

    2002-01-01

    We present high resolution X-ray observations of the narrow line radio galaxy PKS 1138-262 at z = 2.156 with the ACIS-S detector on the Chandra observatory. These observations show that the X-ray emission from 1138-262 is dominated by emission from the AGN with a (rest frame) 2 to 10 keV luminosity of 4x10^{45} erg/s. The relative X-ray and radio properties of the AGN in 1138-262 are similar to those seen for the AGN in the archetype powerful radio galaxy Cygnus A. Between 10% and 25% (depending on energy) of the X-ray emission from 1138--262 is spatially extended on scales of 10'' to 20''. The extended X-ray emission is elongated, with a major axis aligned with that of the radio source. While the X-ray and radio emissions are elongated on similar scales and position angles, there is no one-to-one correspondence between the radio and X-ray features in the source. The most likely origin for the extended X-ray emission in 1138-262 is thermal emission from shocked gas, although we cannot rule-out a contribution ...

  9. XMM-Newton observations of 1A 0535+262 in quiescence

    CERN Document Server

    Doroshenko, Victor; Doroshenko, Rozaliya; Caballero, Isabel; Tsygankov, Sergej; Rothschild, Richard

    2013-01-01

    Accretion onto magnetized neutron stars is expected to be centrifugally inhibited at low accretion rates. Several sources, however, are known to pulsate in quiescence at luminosities below the theoretical limit predicted for the onset of the centrifugal barrier. The source 1A 0535+262 is one of them. Here we present the results of an analysis of a ~50 ks long XMM-Newton observation of 1A 0535+262 in quiescence. At the time of the observation, the neutron star was close to apastron, and the source had remained quiet for two orbital cycles. In spite of this, we detected a pulsed X-ray flux of ~3e-11 erg/cm2/s . Several observed properties, including the power spectrum, remained similar to those observed in the outbursts. Particularly, we have found that the frequency of the break detected in the quiescent noise power spectrum follows the same correlation with flux observed when the source is in outburst. This correlation has been associated with the truncation of the accretion disk at the magnetosphere boundary...

  10. The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.

    Science.gov (United States)

    Shen, Yongchun; Li, Diandian; Tian, Panwen; Shen, Konglong; Zhu, Jing; Feng, Mei; Wan, Chun; Yang, Ting; Chen, Lei; Wen, Fuqiang

    2015-04-01

    Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regarding the association between catalase C-262T polymorphism and cancer risk were identified, and data were retrieved and analyzed by using Review Manager 5.0.24 and STATA 12.0. A total of 18 publications with 22 case-control studies, including 9777 cancer patients and 12,223 controls, met the inclusion criteria. Meta-analysis results showed significant association between catalase C-262 T polymorphism and cancer risk (TT vs CT + CC: odds ratio [OR] = 1.17, 95% confidence interval [CI] = 1.03-1.31, P = 0.01). Subgroup analyses stratified by cancer types suggested the catalase C-262T polymorphism was significantly associated with an increased prostate cancer risk (TT vs CT + CC: OR = 1.61, 95% CI = 1.17-2.22, P = 0.004); for subgroup analyses stratified by ethnicity, no associations between this polymorphism and Asians or whites were identified (CT + TT vs CC: OR = 1.11, 95% CI = 0.98-1.26, P = 0.09 for whites; OR = 1.19, 95% CI = 0.78-1.80, P = 0.42 for Asians). In summary, the catalase C-262T polymorphism may be a risk factor for cancer with cancer type-specific effects. Further studies should be performed to confirm these findings.

  11. Signature of Plausible Accreting Supermassive Black Holes in Mrk 261/262 and Mrk 266

    Directory of Open Access Journals (Sweden)

    Gagik Ter-Kazarian

    2013-01-01

    Full Text Available We address the neutrino radiation of plausible accreting supermassive black holes closely linking to the 5 nuclear components of galaxy samples of Mrk 261/262 and Mrk 266. We predict a time delay before neutrino emission of the same scale as the age of the Universe. The ultrahigh energy neutrinos are produced in superdense protomatter medium via simple (quark or pionic reactions or modified URCA processes (G. Gamow was inspired to name the process URCA after the name of a casino in Rio de Janeiro. The resulting neutrino fluxes for quark reactions are ranging from to , where is the opening parameter. For pionic and modified URCA reactions, the fluxes are and , respectively. These fluxes are highly beamed along the plane of accretion disk, peaked at ultrahigh energies, and collimated in smaller opening angle .

  12. 262例肺结核咯血临床分析

    Institute of Scientific and Technical Information of China (English)

    吴友仁

    2014-01-01

    Objective: Analyzing the related factors of pulmonary tuberculosis hemoptysis, and improving the cure rate. Methods: 262 cases of pulmonary tuberculosis hemoptysis patients' age, gender, smoking status, cause and lung imaging and sputum bacteria inspection, onset time, treatment and prognosis were retrospectively analyzed.Results: male along with the pulmonary tuberculosis hemoptysis offen has a history of smoking.Tuberculosis with hemoptysis most commonly develop in young adults. Patients with pulmonary cavity formation prone to haemoptysis;No obvious relationship between sputum bacterium experiment and pulmonary tuberculosis with hemoptysis; Haemoptysis in night with a higher incidence.Conclusion: pulmonary tuberculosis hemoptysis is associated with a variety of factors.Using comprehensive treatment can obtain higher cure rate .%目的:分析肺结核咯血的相关因素,提高救治成功率。方法对我科262例肺结核咯血患者的性别、年龄、吸烟与否、诱因、肺部影像学、痰菌检查、发病时间、治疗以及预后进行回顾性分析。结果肺结核咯血男性居多,且多有吸烟史,好发于青壮年。肺部有空洞形成者易发生咯血;肺结核咯血与痰菌阳性与否无明显关系;夜间咯血发生率较高。结论肺结核咯血与多种因素相关,综合治疗能获得更高的治愈率。

  13. Residue 259 in protein-tyrosine phosphatase PTP1B and PTPα determines the flexibility of glutamine 262

    DEFF Research Database (Denmark)

    Peters, Günther H.j.; Iversen, L.F.; Andersen, H.S.;

    2004-01-01

    (cat). Additionally, in the simulation with the Michaelis-Menten complexes, we found that a glutamine in position 259 induces steric hindrance by pushing the Gln262 side chain further toward the substrate and thereby negatively affecting K-m as indicated by kinetic studies. Detailed analysis of the water structure...

  14. Closure Report for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This Closure Report (CR) documents the activities undertaken to close Corrective Action Unit (CAU) 262: Area 25 Septic Systems and Underground Discharge Point, in accordance with the Federal Facility Agreement and Consent Order (FFACO) of 1996. Site closure was performed in accordance with the Nevada Division of Environmental Protection (NDEP)-approved Corrective Action Plan (CAP) for CAU 262 (U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office [NNSA/NV, 2002a]). CAU 262 is located at the Nevada Test Site (NTS) approximately 105 kilometers (65 miles) northwest of Las Vegas, Nevada. CAU 262 consists of the following nine Corrective Action Sites (CASs) located in Area 25 of the NTS: CAS 25-02-06, Underground Storage tank CAS 25-04-06, Septic Systems A and B CAS 25-04-07, Septic System CAS 25-05-03, Leachfield CAS 25-05-05, Leachfield CAS 25-05-06, Leachfield CAS 25-05-08, Radioactive Leachfield CAS 25-05-12, Leachfield CAS 25-51-01, Dry Well

  15. The Catalase –262C/T Promoter Polymorphism and Diabetic Complications in Caucasians with Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Kátia Gonçalves dos Santos

    2006-01-01

    Full Text Available Catalase is a central antioxidant enzyme constituting the primary defense against oxidative stress. In this study, we investigated whether the functional –262C/T polymorphism in the promoter of catalase gene is associated with the presence of diabetic retinopathy (DR, diabetic nephropathy (DN and ischemic heart disease (IHD in 520 Caucasian-Brazilians with type 2 diabetes. The –262C/T polymorphism was also examined in 100 Caucasian blood donors. Patients underwent a clinical and laboratory evaluation consisting of a questionnaire, physical examination, assessment of diabetic complications and laboratory tests. Genotype analysis was performed using the polymerase chain reaction followed by digestion with restriction enzyme. The genotype and allele frequencies of the –262C/T polymorphism in patients with type 2 diabetes were very similar to those of blood donors (T allele frequency = 0.20 and 0.18, respectively. Likewise, there were no differences in either genotype or allele frequencies between type 2 diabetic patients with or without DR, DN or IHD. Thus, our results do not support the hypothesis that the –262C/T polymorphism is related to the development of DR, DN or IHD in patients with type 2 diabetes. Further studies are necessary to elucidate the role of catalase gene polymorphisms in the pathogenesis of diabetic complications.

  16. New rhodomycin analogs, SS-288A and SS-288B, produced by a Streptomyces violaceus A262 mutant.

    Science.gov (United States)

    Saito, S; Katsuda, Y; Johdo, O; Yoshimoto, A

    1995-01-01

    Two new rhodomycin metabolites, SS-288A and SS-288B, were specifically produced by a blocked mutant obtained from Streptomyces violaceus A262 and were respectively identified as 7,10-di(O-rhodosaminyl-deoxyfucosyl-deoxyfucosyl)-beta -rhodomycinone and -beta-isorhodomycinone. PMID:7765964

  17. Optimum Design of 2.62 GHz Asymmetrical Doherty Power Amplifier%2.62GHz非对称Doherty功率放大器的优化设计

    Institute of Scientific and Technical Information of China (English)

    于利俊; 高建军

    2012-01-01

    The characteristics of asymmetrical Doherty power amplifier ( ADPA) were researched. A higher power LDMOSFET was used and matched with the asymmetrical load-modulate theory in the peak way. For the job above, the average efficiency and peak output power were improved. The memory effect of the power amplifier were researched and several methods were introduced to reduce it. The symmetrical and asymmetrical Doherty Pas were simulated with the advanced design system (ADS) and implemented using 100 W and 140 W LDMOSFETs for verification. For a 2. 62 GHz single carrier W-CDMA signal, the measured average output power of the amplifier is 47. 5 dBm, the measured peak power is 55 dBm, and the measured power added efficiency (PAE) is 41%. After the digital pre-distortion (DPD) calibration, the measured adjacent channel leakage ratio ( ACLR) is lower than -60 dBc. It completely meets the requirements of the system.%对非对称Doherty功率放大器(ADPA)的特性进行了研究.峰管采用更高功率的LDMOS管,用非对称负载调制理论做功率匹配,提高了功率放大器的平均效率和峰值输出功率.对功率放大器记忆效应进行了研究,介绍了多种减小记忆效应的方法.用ADS软件分别仿真了对称和非对称Doherty功率放大器,最后采用了100 W和140 W的LDMOS功率管进行实验验证.测试结果表明:2.62 GHz单载波W-CDMA信号平均输出功率为47.5 dBm,峰值输出功率为55dBm,功率附加效率(PAE)为41%,经数字预失真(DPD)校正后,近端(5 MHz)临信道泄漏比(ACLR)达到- 60 dBc以下,完全达到系统要求的指标.

  18. Laser Argon-40-Argon-39 Age Studies of Dar Al Gani 262 Lunar Meteorite

    Science.gov (United States)

    Fernandes, V. A.; Burgess, R.; Turner, G.

    1999-01-01

    The lunar meteorite Dar al Gani 262 (DAG 262) was found in the Sahara Desert in Libya on March 23,1997. This was the first lunar meteorite found in a desert and is the thirteenth lunar meteorite discovered. DAG 262 is a polymict anorthositic lunar highland breccia. The Ar-40-Ar-39 dating technique has been applied to DAG 262 in an attempt to determine the crystallization age and shock events experienced by this meteorite. Previous studies have indicated that this meteorite may have suffered up to four shock events. Due to the brecciated nature of the rock and the likelihood of multiple shock events, a laser-probe technique has been used to analyze individual components (minerals and clasts) of the meteorite. The sample supplied to us ( about 1.5 g) shows two distinct clast types (1) feldspathic and (2) basaltic, the latter not having been previously described. Plagioclases show fractures and undulatory extinction as the result of shock events. The feldspathic clast has small, round low-Ca pyroxenes distributed within it. Electron-microprobe analyses of feldspar and pyroxene are given. The bulk composition as determined by suggests that the source of this clast is the ferroan-anorthositic suite. The basaltic clast shows a very fine intergranular texture with some larger plagioclase grains. The two clasts are separated by a melt-glass matrix that contains plagioclase with the same chemical composition as those plagioclases within the feldspathic clast. A devitrified mafic-glass spherule of - 150 mm diameter was identified within the matrix as well as other small fragments of possible glass spheres. Some dendritic veins can be observed on the outer part of the section, which formed after breccia lithification. Two laser Ar-40-Ar-39 experiments are being carried out: (1) infrared laser-stepped heating of feldspathic fragments that have been separated from the meteorite; and (2) ultraviolet laser spot fusion (50 micron) of a slice of meteorite (about 1.0 x 0.5 cm

  19. Observations of radio galaxy mrc 1138-262: merging galaxies embedded in a giant Lya halo

    Directory of Open Access Journals (Sweden)

    J. D. Kurk

    2002-01-01

    Full Text Available La radio galaxia MRC 1138-262 a z = 2:16 probablemente es una galaxia de mayor brillo en el c umulo que se encuentra un estado inicial de evoluci on. Aqu presentamos observaciones del luminoso halo de l neas de emisi on y de las componentes estelares de esta radio galaxia. Las im agenes opticas de banda angosta en H muestran un halo mucho m as peque~no con una morfolog a muy diferente al halo Ly . Proponemos un modelo en el que la parte interior del halo est a fotoionizada directamente por iluminaci on del n ucleo activo de la galaxia o por fotones UV de estrellas j ovenes. Lejos del n ucleo ( 25 kpc hay una regi on de emisi on Ly muy aumentada. En esa posici on es probable que la ionizaci on por choques sea importante seg un indica la curvatura del radio jet. La espectroscop a de varias nubes de cont nuo en el halo muestra que, aunque hay diferencias entre las caracter sticas de emisi on y de absorci on de espectros de varias regiones, estas tienen propiedades similares a las galaxias con \\Lyman-break". Esto es evidencia adicional en favor de un escenario en que galaxias masivas se forman jer arquicamente a partir de bloques m as peque~nos.

  20. GltX from Clostridium saccharobutylicum NCP262: glutamate synthase or oxidoreductase?

    Science.gov (United States)

    Stutz, Helen E; Reid, Sharon J

    2004-01-01

    A full-length gene encoding a homologue of the small subunit of the glutamate synthase (GOGAT) enzyme was isolated from the anaerobic bacterium, Clostridium saccharobutylicum NCP262, which has been used extensively for the commercial production of solvents. Using a screening system designed to isolate genes involved in electron transport, plasmid pMET13C1 was isolated. Analysis of this plasmid identified a gene (1245 bp) with a predicted approximately 46-kDa product, which was associated with reductive activation of the pro-drug metronidazole. The deduced 414-amino-acid sequence was not typical of electron transport proteins, but rather shared striking homology to the small (beta) subunit of the GOGAT enzyme and other beta subunit-like polypeptides, and was thus designated gltX. Although all the functional domains typical of GOGAT beta subunits were conserved in this GltX protein, certain sequence features were not conserved. Furthermore, it was independently transcribed, did not lie adjacent to a GOGAT large subunit (alpha) domain, and its expression was not regulated by nitrogen conditions. These results provide additional support for current theories on the evolutionary relationships of GOGAT beta subunit domains in bacteria, and suggest that GltX belongs to a more general family of oxidoreductases, which is used in a context other than glutamate biosynthesis to transfer electrons to a currently unknown protein domain. PMID:14732492

  1. Anthracycline metabolites from Streptomyces violaceus A262. III. New anthracycline obelmycins produced by a variant strain SE2-2385.

    Science.gov (United States)

    Johdo, O; Watanabe, Y; Ishikura, T; Yoshimoto, A; Naganawa, H; Sawa, T; Takeuchi, T

    1991-10-01

    New anthracycline antibiotics, designated as obelmycins A, D, E, F and G, were isolated from the culture broth of a variant strain of beta-rhodomycin-producing Streptomyces violaceus A262, identified as beta-isorhodomycinone glycosides and gamma-isorhodomycinone glycosides and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with some known anthracyclines. PMID:1955396

  2. Physical and genetic map of the Clostridium saccharobutylicum (formerly Clostridium acetobutylicum) NCP 262 chromosome.

    Science.gov (United States)

    Keis, S; Sullivan, J T; Jones, D T

    2001-07-01

    A physical and genetic map of the Clostridium saccharobutylicum NCP 262 chromosome was constructed. The order of macrorestriction fragments was determined by analysing fragments generated after single and double digestion with the restriction enzymes BssHII, I-CeuI, Sse8387I, RsrII and SfiI and separation by PFGE. The I-CeuI backbone of C. saccharobutylicum was constructed by indirect end-labelling with rrs- and 3' rrl-specific probes located on either side of the I-CeuI site in the rrn operon, and reciprocal separation of BssHII and I-CeuI digestion products by two-dimensional PFGE. The positions of BssHII fragments on the physical map were determined using a library of linking clones containing BssHII cleavage sites. The size of the circular genome was estimated to be 5.3 Mb with a mean resolution of approximately 140 kb. The chromosome of C. saccharobutylicum contains 12 rrn operons, located on 46% of the chromosome, which are transcribed divergently from the deduced origin of replication. The genetic map was constructed by determining the location of 28 genes involved in house-keeping, heat-shock response, sporulation, electron transfer and acid- and solvent-formation. Comparison of the C. saccharobutylicum genetic map with those of the spore-forming bacteria Bacillus subtilis, Clostridium acetobutylicum, Clostridium perfringens and Clostridium beijerinckii indicated C. saccharobutylicum to be most similar to the latter two Clostridium species, with the order of the genes within the gyrAB and recA loci being conserved. PMID:11429467

  3. Near-infrared observations of the Be/X-ray binary pulsar A0535+262

    Institute of Scientific and Technical Information of China (English)

    Sachindra Naik; Blesson Mathew; D. P. K. Banerjee; N. M. Ashok; Rajeev R. Jaiswal

    2012-01-01

    We present the results obtained from extensive near-infrared (IR) spectro-scopic and photometric observations of the Be/X-ray binary A0535+262/HDE 245770 at different phases of its ~ 111 d orbital period.This observation campaign is part of the monitoring program of selective Be/X-ray binary systems aimed at understanding X-ray and near-IR properties at different orbital phases,especially during the periastron passage of the neutron star.The near-IR observations presented here were carried out using the 1.2 m telescope at the Mt.Abu IR Observatory.Though the source was relatively faint for spectroscopic observations with the 1.2 m telescope,we monitored the source closely during the 2011 February-March giant X-ray outburst to primarily investigate whether any drastic changes in the near-IR JHK spectra took place at the periastron passage.Changes of such a striking nature were expected to be detectable in our spectra.Photometric observations of the Be star show a gradual and systematic fading in the JHK light curves since the onset of the X-ray outburst,which could suggest a mild evacuation/truncation of the circumstellar disk of the Be companion.Near-IR spectroscopy of the object shows that the JHK spectra are dominated by the emission lines of hydrogen Brackett and Paschen series and HeI lines at 1.0830,1.7002 and 2.0585 μm.The presence of all the hydrogen emission lines in the JHK spectra,along with the absence of any significant change in the continuum of the Be companion during X-ray quiescent and X-ray outburst phases,suggests that the near- IR line emitting regions of the disk are not significantly affected during the X-ray outburst.

  4. Abell 262 and RXJ0341: Two Brightest Cluster Galaxies with Line Emission Blanketing a Cool Core

    Science.gov (United States)

    Edwards, Louise O. V.; Heng, Renita

    2014-08-01

    Over the last decade, integral field (IFU) analysis of the brightest cluster galaxies (BCGs) in several cool core clusters has revealed the central regions of these massive old red galaxies to be far from dead. Bright line emission alongside extended X-ray emission links nearby galaxies, is superposed upon vast dust lanes and extends out in long thin filaments from the galaxy core. Yet, to date no unifying picture has come into focus, and the activity across systems is currently seen as a grab-bag of possibile emission line mechanisms. Our primary goal is to work toward a consistent picture for why the BCGs seem are undergoing a renewed level of activity. One problem is most of the current data remains focused on mapping the very core of the BCG, but neglects surrounding galaxies. We propose to discover the full extent of line emission in a complementary pair of BCGs. In Abell 262, an extensive dust patch screens large portions of an otherwise smooth central galaxy, whereas RXJ0341 appears to be a double-core dust free BCG. We will map the full extent of the line emission in order to deduce whether the line emission is a product of local interactions, or the large-scale cluster X-ray gas. The narrow band filter set and large FOV afforded by the the Mayall MOSAIC-1 (MOSA) imager allows us to concurrently conduct an emission line survey of both clusters, locating all line emitting members and beginning a search for the effect of the environment of the different regions (outskirts vs. cluster core) out to the virial radius. We will combine our results with publically available data from 2MASS to determine the upper limits on specific star formation in the BCG and other cluster galaxies within the cluster virial radius.

  5. Physical and genetic map of the Clostridium saccharobutylicum (formerly Clostridium acetobutylicum) NCP 262 chromosome.

    Science.gov (United States)

    Keis, S; Sullivan, J T; Jones, D T

    2001-07-01

    A physical and genetic map of the Clostridium saccharobutylicum NCP 262 chromosome was constructed. The order of macrorestriction fragments was determined by analysing fragments generated after single and double digestion with the restriction enzymes BssHII, I-CeuI, Sse8387I, RsrII and SfiI and separation by PFGE. The I-CeuI backbone of C. saccharobutylicum was constructed by indirect end-labelling with rrs- and 3' rrl-specific probes located on either side of the I-CeuI site in the rrn operon, and reciprocal separation of BssHII and I-CeuI digestion products by two-dimensional PFGE. The positions of BssHII fragments on the physical map were determined using a library of linking clones containing BssHII cleavage sites. The size of the circular genome was estimated to be 5.3 Mb with a mean resolution of approximately 140 kb. The chromosome of C. saccharobutylicum contains 12 rrn operons, located on 46% of the chromosome, which are transcribed divergently from the deduced origin of replication. The genetic map was constructed by determining the location of 28 genes involved in house-keeping, heat-shock response, sporulation, electron transfer and acid- and solvent-formation. Comparison of the C. saccharobutylicum genetic map with those of the spore-forming bacteria Bacillus subtilis, Clostridium acetobutylicum, Clostridium perfringens and Clostridium beijerinckii indicated C. saccharobutylicum to be most similar to the latter two Clostridium species, with the order of the genes within the gyrAB and recA loci being conserved.

  6. Development of an in vivo methylation system for the solventogen Clostridium saccharobutylicum NCP 262 and analysis of two endonuclease mutants.

    Science.gov (United States)

    Lesiak, Justyna Maria; Liebl, Wolfgang; Ehrenreich, Armin

    2014-10-20

    The genome of the biotechnologically important solventogenic Clostridium saccharobutylicum NCP 262 contains two operons coding for genes of presumed type I RM systems belonging to the families A and C. They represent a limiting factor for the development of transformation and conjugation protocols. We established an efficient triparental mating system to transfer DNA to C. saccharobutylicum by conjugation, which includes an in vivo methylation of the donor DNA. Furthermore we describe increased rates of conjugation in knock-out mutants of the restrictase subunits of both RM systems. PMID:25087740

  7. Development of an in vivo methylation system for the solventogen Clostridium saccharobutylicum NCP 262 and analysis of two endonuclease mutants.

    Science.gov (United States)

    Lesiak, Justyna Maria; Liebl, Wolfgang; Ehrenreich, Armin

    2014-10-20

    The genome of the biotechnologically important solventogenic Clostridium saccharobutylicum NCP 262 contains two operons coding for genes of presumed type I RM systems belonging to the families A and C. They represent a limiting factor for the development of transformation and conjugation protocols. We established an efficient triparental mating system to transfer DNA to C. saccharobutylicum by conjugation, which includes an in vivo methylation of the donor DNA. Furthermore we describe increased rates of conjugation in knock-out mutants of the restrictase subunits of both RM systems.

  8. Core drilling of hydco drillholes ONK-PP262 and ONK-PP274 in ONKALO at Olkiluoto 2010

    Energy Technology Data Exchange (ETDEWEB)

    Toropainen, V. [Suomen Malmi Oy, Espoo (Finland)

    2011-10-15

    Suomen Malmi Oy (Smoy) core drilled two drillholes for HYDCO-program in ONKALO at Eurajoki, Olkiluoto in 2010. The drillhole ONK-PP262 was drilled in May 2010 and the drillhole ONK-PP274 in December 2010. The lengths of the drillholes are 25.02 and 23.88 m respectively. The drillholes are 75.7 mm by diameter. The drillholes were drilled in the investigation niche 4 at the access tunnel chainage 3747. The hydraulic DE 130 drilling rig was used. The drilling water was taken from the ONKALO drilling water pipeline and premixed sodium fluorescein was used as a label agent in the drilling water. The drillholes were measured with EMS deviation survey tool. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The main rock types in the drillholes are veined gneiss and pegmatitic granite. The average fracture frequencies in both drill cores are 1.4 pcs/m. The average RQD values in the drillcores are 97.2 % (ONK-PP262) and 98.6 % (ONK-PP274). (orig.)

  9. A procedural manual for measurement of uranium and thorium isotopes utilizing the USGS-Stanford Finnegan Mat 262

    Science.gov (United States)

    Shamp, Donald D.

    2001-01-01

    Over the past several decades investigators have extensively examined the 238U-234U- 230Th systematics of a variety of geologic materials using alpha spectroscopy. Analytical uncertainty for 230Th by alpha spectroscopy has been limited to about 2% (2σ). The advantage of thermal ionization mass spectroscopy (TIMS), introduced by Edwards and co-workers in the late 1980’s is the increased detectability of these isotopes by a factor of ~200, and decreases in the uncertainty for 230Th to about 5‰ (2σ) error. This report is a procedural manual for using the USGS-Stanford Finnegan-Mat 262 TIMS to collect and isolate Uranium and Thorium isotopic ratio data. Chemical separation of Uranium and Thorium from the sample media is accomplished using acid dissolution and then processed using anion exchange resins. The Finnegan-Mat262 Thermal Ionization Mass Spectrometer (TIMS) utilizes a surface ionization technique in which nitrates of Uranium and Thorium are placed on a source filament. Upon heating, positive ion emission occurs. The ions are then accelerated and focused into a beam which passes through a curved magnetic field dispersing the ions by mass. Faraday cups and/or an ion counter capture the ions and allow for quantitative analysis of the various isotopes.

  10. Pavla Models出品的1/72 Me-262战机驾驶舱罩和轮子

    Institute of Scientific and Technical Information of China (English)

    克里斯·史密斯

    2010-01-01

    @@ Me-262战机在历史上是很著名的,关于它的历史文献我特意单独留下了.我刚开始模型制作时就犯了错误.我计划在这架飞机上打桩,因为驾驶舱罩是扭曲的.瞧,真怪!接着就有评论文章列举说有我想要的驾驶舱罩和额外的轮子套件卖.于是我订购了并且收到了回信.可以想象一下当我拿到1/48的Me-262时激动的心情!所以1/72的相关套件也会很不错的.因为IPMS(一个网站)给我送来的那些好东西我都能用上.我迅速登陆Amazon.com,一个星期后,1/72威望的相关套件就被送到我家门口了.

  11. A 91 kb microdeletion at Xq26.2 involving the GPC3 gene in a female fetus with Simpson-Golabi-Behmel syndrome detected by prenatal arrayCGH

    DEFF Research Database (Denmark)

    Ramsing, Mette; Becher, Naja Helene; Christensen, Rikke;

    A 91 kb microdeletion at Xq26.2 involving the GPC3 gene in a female fetus with Simpson-Golabi-Behmel syndrome detected by prenatal arrayCGH......A 91 kb microdeletion at Xq26.2 involving the GPC3 gene in a female fetus with Simpson-Golabi-Behmel syndrome detected by prenatal arrayCGH...

  12. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons.

    Directory of Open Access Journals (Sweden)

    Hamid Y Qureshi

    Full Text Available b-Amyloid peptide accumulation, tau hyperphosphorylation, and synapse loss are characteristic neuropathological symptoms of Alzheimer's disease (AD. Tau hyperphosphorylation is suggested to inhibit the association of tau with microtubules, making microtubules unstable and causing neurodegeneration. The mechanism of tau phosphorylation in AD brain, therefore, is of considerable significance. Although PHF-tau is phosphorylated at over 40 Ser/Thr sites, Ser(262 phosphorylation was shown to mediate b-amyloid neurotoxicity and formation of toxic tau lesions in the brain. In vitro, PKA is one of the kinases that phosphorylates tau at Ser(262, but the mechanism by which it phosphorylates tau in AD brain is not very clear. 14-3-3z is associated with neurofibrillary tangles and is upregulated in AD brain. In this study, we show that 14-3-3z promotes tau phosphorylation at Ser(262 by PKA in differentiating neurons. When overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in Ser(262 phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. More importantly, the level of pre-synaptic protein synaptophysin was significantly reduced. Downregulation of synaptophysin in 14-3-3z overexpressing neurons was mitigated by inhibiting the proteosome, indicating that 14-3-3z promotes proteosomal degradation of synaptophysin. When 14-3-3z overexpressing neurons were treated with the microtubule stabilizing drug taxol, tau Ser(262 phosphorylation decreased and synaptophysin level was restored. Our data demonstrate that overexpression of 14-3-3z accelerates proteosomal turnover of synaptophysin by promoting the destabilization of microtubules. Synaptophysin is involved in synapse formation and neurotransmitter release. Our results suggest that 14-3-3z may cause synaptic pathology by reducing synaptophysin levels in the brains of patients suffering

  13. Observations of radio galaxy MRC 1138-262 merging galaxies embedded in a giant Lyman alpha halo

    CERN Document Server

    Kurk, J D; Miley, G K; Pentericci, L

    2001-01-01

    The radio galaxy MRC 1138-262 at z=2.16 is most likely a brightest cluster galaxy in an early stage of evolution. Here we present observations of the luminous emission line halo and the stellar components of this radio galaxy. Optical narrow band imaging shows a very extended (about 160 kpc) and luminous Lyman alpha halo. Infrared narrow band imaging reveals a much smaller H alpha halo with a very different morphology. We advocate a model in which the inner part of the halo is photoionized by direct AGN illumination or by UV photons from young stars. Far from the nucleus (about 25 kpc), there is a region of greatly enhanced Lyman alpha emission. At this location, it is likely that shock ionization is important as indicated by a bend in the radio jet. Spectroscopy of several continuum clumps in the halo shows that, although there are striking differences between the emission and absorption features of the spectra of various regions, they have properties similar to those of Lyman-break galaxies. This is further...

  14. Anthracycline metabolites from Streptomyces violaceus A262. II. New anthracycline epelmycins produced by a blocked mutant strain SU2-730.

    Science.gov (United States)

    Johdo, O; Watanabe, Y; Ishikura, T; Yoshimoto, A; Naganawa, H; Sawa, T; Takeuchi, T

    1991-10-01

    New anthracycline antibiotics, identified as epsilon-rhodomycinone glycosides, were isolated from the culture broth of a blocked mutant of beta-rhodomycin-producing Streptomyces violaceus A262. They were designated as epelmycins A, B, C, D and E, and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with known anthracycline antibiotics. PMID:1955395

  15. High spatial resolution optical imaging of the multiple T Tauri system LkH{\\alpha} 262/LkH{\\alpha} 263

    CERN Document Server

    Velasco, S; Oscoz, A; Mackay, C; Labadie, L; Garrido, A Pérez; Crass, J; Díaz-Sánchez, A; Femenía, B; González-Escalera, V; King, D L; López, R L; Puga, M; Rodríguez-Ramos, L F; Zuther, J

    2016-01-01

    We report high spatial resolution i' band imaging of the multiple T Tauri system LkH$\\alpha$ 262/LkH$\\alpha$ 263 obtained during the first commissioning period of the Adaptive Optics Lucky Imager (AOLI) at the 4.2 m William Herschel Telescope, using its Lucky Imaging mode. AOLI images have provided photometry for each of the two components LkH$\\alpha$ 263 A and B (0.41 arcsec separation) and marginal evidence for an unresolved binary or a disc in LkH$\\alpha$ 262. The AOLI data combined with previously available and newly obtained optical and infrared imaging show that the three components of LkH$\\alpha$ 263 are co-moving, that there is orbital motion in the AB pair, and, remarkably, that LkH$\\alpha$ 262-263 is a common proper motion system with less than 1 mas/yr relative motion. We argue that this is a likely five-component gravitationally bounded system. According to BT-settl models the mass of each of the five components is close to 0.4 M$_{\\odot}$ and the age is in the range 1-2 Myr. The presence of discs...

  16. Extreme Gas Kinematics in the z=2.2 Powerful Radio Galaxy MRC1138-262: Evidence for Efficient AGN Feedback in the Early Universe?

    Energy Technology Data Exchange (ETDEWEB)

    Nesvadba, N H; Lehnert, M D; Eisenhauer, F; Gilbert, A M; Tecza, M; Abuter, R

    2007-06-26

    To explain the properties of the most massive low-redshift galaxies and the shape of their mass function, recent models of galaxy evolution include strong AGN feedback to complement starburst-driven feedback in massive galaxies. Using the near-infrared integral-field spectrograph SPIFFI on the VLT, we searched for direct evidence for such a feedback in the optical emission line gas around the z = 2.16 powerful radio galaxy MRC1138-262, likely a massive galaxy in formation. The kpc-scale kinematics, with FWHMs and relative velocities {approx}< 2400 km s{sup -1} and nearly spherical spatial distribution, do not resemble large-scale gravitational motion or starburst-driven winds. Order-of-magnitude timescale and energy arguments favor the AGN as the only plausible candidate to accelerate the gas, with a total energy injection of {approx} few x 10{sup 60} ergs or more, necessary to power the outflow, and relatively efficient coupling between radio jet and ISM. Observed outflow properties are in gross agreement with the models, and suggest that AGN winds might have a similar, or perhaps larger, cosmological significance than starburst-driven winds, if MRC1138-262 is indeed archetypal. Moreover, the outflow has the potential to remove significant gas fractions ({approx}< 50%) from a > L* galaxy within a few 10 to 100 Myrs, fast enough to preserve the observed [{alpha}/Fe] overabundance in massive galaxies at low redshift. Using simple arguments, it appears that feedback like that observed in MRC1138-262 may have sufficient energy to inhibit material from infalling into the dark matter halo and thus regulate galaxy growth as required in some recent models of hierarchical structure formation.

  17. Gamma-ray observations of the Be/pulsar binary 1A 0535+262 during a giant X-ray outburst

    CERN Document Server

    Acciari, V A; Araya, M; Arlen, T; Aune, T; Beilicke, M; Benbow, W; Bradbury, S M; Buckley, J H; Bugaev, V; Byrum, K; Cannon, A; Cesarini, A; Ciupik, L; Collins-Hughes, E; Cui, W; Dickherber, R; Duke, C; Falcone, A; Finley, J P; Fortson, L; Furniss, A; Galante, N; Gall, D; Godambe, S; Griffin, S; Guenette, R; Gyuk, G; Hanna, D; Holder, J; Hughes, G; Hui, C M; Humensky, T B; Imran, A; Kaaret, P; Kertzman, M; Krawczynski, H; Krennrich, F; Madhavan, A S; Maier, G; Majumdar, P; McArthur, S; Moriarty, P; Ong, R A; Otte, A N; Pandel, D; Park, N; Perkins, J S; Pohl, M; Prokoph, H; Quinn, J; Ragan, K; Reyes, L C; Reynolds, P T; Roache, E; Rose, H J; Saxon, D B; Sembroski, G H; Senturk, G Demet; Smith, A W; Tešić, G; Theiling, M; Thibadeau, S; Varlotta, A; Vincent, S; Vivier, M; Wakely, S P; Ward, J E; Weekes, T C; Weinstein, A; Weisgarber, T; Weng, S; Williams, D A; Wood, M; Zitzer, B

    2011-01-01

    Giant X-ray outbursts, with luminosities of about $ 10^{37}$ erg s$^{-1}$, are observed roughly every 5 years from the nearby Be/pulsar binary 1A 0535+262. In this article, we present observations of the source with VERITAS at very-high energies (VHE; E$>$100 GeV) triggered by the X-ray outburst in December 2009. The observations started shortly after the onset of the outburst, and they provided comprehensive coverage of the episode, as well as the 111-day binary orbit. No VHE emission is evident at any time. We also examined data from the contemporaneous observations of 1A 0535+262 with the Fermi/LAT at high energy photons (HE; E$>$0.1 GeV) and failed to detect the source at GeV energies. The X-ray continua measured with the Swift/XRT and the RXTE/PCA can be well described by the combination of blackbody and Comptonized emission from thermal electrons. Therefore, the gamma-ray and X-ray observations suggest the absence of a significant population of non-thermal particles in the system. This distinguishes 1A~...

  18. Corrective Action Investigation Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This corrective action investigation plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 262 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 262 consists of nine Corrective Action Sites (CASs): Underground Storage Tank (25-02-06), Septic Systems A and B (25-04-06), Septic System (25-04-07), Leachfield (25-05-03), Leachfield (25-05-05), Leachfield (25-05-06), Radioactive Leachfield (25-05-08), Leachfield (25-05-12), and Dry Well (25-51-01). Situated in Area 25 at the Nevada Test Site (NTS), sites addressed by CAU 262 are located at the Reactor-Maintenance, Assembly, and Disassembly (R-MAD); Test Cell C; and Engine-Maintenance, Assembly, and Disassembly (E-MAD) facilities. The R-MAD, Test Cell C, and E-MAD facilities supported nuclear rocket reactor and engine testing as part of the Nuclear Rocket Development Station. The activities associated with the testing program were conducted between 1958 and 1973. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern (COPCs) for the site include oil/diesel-range total petroleum hydrocarbons, volatile organic compounds, semivolatile organic compounds, polychlorinated biphenyls, Resource Conservation and Recovery Act metals, and gamma-emitting radionuclides, isotopic uranium, isotopic plutonium, strontium-90, and tritium. The scope of the corrective action field investigation at the CAU will include the inspection of portions of the collection systems, sampling the contents of collection system features in situ of leachfield logging materials, surface soil sampling, collection of samples of soil underlying the base of inlet and outfall ends of septic tanks and outfall ends of diversion structures and distribution boxes, collection of soil samples from biased or a combination of

  19. Corrective Action Investigation Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada, Revision No. 1 (9/2001)

    Energy Technology Data Exchange (ETDEWEB)

    NNSA/NV

    2000-07-20

    This corrective action investigation plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 262 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 262 consists of nine Corrective Action Sites (CASs): Underground Storage Tank (25-02-06), Septic Systems A and B (25-04-06), Septic System (25-04-07), Leachfield (25-05-03), Leachfield (25-05-05), Leachfield (25-05-06), Radioactive Leachfield (25-05-08), Leachfield (25-05-12), and Dry Well (25-51-01). Situated in Area 25 at the Nevada Test Site (NTS), sites addressed by CAU 262 are located at the Reactor-Maintenance, Assembly, and Disassembly (R-MAD); Test Cell C; and Engine-Maintenance, Assembly, and Disassembly (E-MAD) facilities. The R-MAD, Test Cell C, and E-MAD facilities supported nuclear rocket reactor and engine testing as part of the Nuclear Rocket Development Station. The activities associated with the testing program were conducted between 1958 and 1973. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern (COPCs) for the site include oil/diesel-range total petroleum hydrocarbons, volatile organic compounds, semivolatile organic compounds, polychlorinated biphenyls, Resource Conservation and Recovery Act metals, and gamma-emitting radionuclides, isotopic uranium, isotopic plutonium, strontium-90, and tritium. The scope of the corrective action field investigation at the CAU will include the inspection of portions of the collection systems, sampling the contents of collection system features in situ of leachfield logging materials, surface soil sampling, collection of samples of soil underlying the base of inlet and outfall ends of septic tanks and outfall ends of diversion structures and distribution boxes, collection of soil samples from biased or a combination of

  20. Corrective Action Investigation Plan for Corrective Action Unit 262: Area 25 Septic Systems and Underground Discharge Point, Nevada Test Site, Nevada, Revision No. 1 (9/2001)

    International Nuclear Information System (INIS)

    This corrective action investigation plan contains the U.S. Department of Energy, Nevada Operations Office's approach to collect data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 262 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 262 consists of nine Corrective Action Sites (CASs): Underground Storage Tank (25-02-06), Septic Systems A and B (25-04-06), Septic System (25-04-07), Leachfield (25-05-03), Leachfield (25-05-05), Leachfield (25-05-06), Radioactive Leachfield (25-05-08), Leachfield (25-05-12), and Dry Well (25-51-01). Situated in Area 25 at the Nevada Test Site (NTS), sites addressed by CAU 262 are located at the Reactor-Maintenance, Assembly, and Disassembly (R-MAD); Test Cell C; and Engine-Maintenance, Assembly, and Disassembly (E-MAD) facilities. The R-MAD, Test Cell C, and E-MAD facilities supported nuclear rocket reactor and engine testing as part of the Nuclear Rocket Development Station. The activities associated with the testing program were conducted between 1958 and 1973. Based on site history collected to support the Data Quality Objectives process, contaminants of potential concern (COPCs) for the site include oil/diesel-range total petroleum hydrocarbons, volatile organic compounds, semivolatile organic compounds, polychlorinated biphenyls, Resource Conservation and Recovery Act metals, and gamma-emitting radionuclides, isotopic uranium, isotopic plutonium, strontium-90, and tritium. The scope of the corrective action field investigation at the CAU will include the inspection of portions of the collection systems, sampling the contents of collection system features in situ of leachfield logging materials, surface soil sampling, collection of samples of soil underlying the base of inlet and outfall ends of septic tanks and outfall ends of diversion structures and distribution boxes, collection of soil samples from biased or a combination of

  1. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

    Science.gov (United States)

    Broderick, Peter; Chen, Bowang; Johnson, David C; Försti, Asta; Vijayakrishnan, Jayaram; Migliorini, Gabriele; Dobbins, Sara E; Holroyd, Amy; Hose, Dirk; Walker, Brian A; Davies, Faith E; Gregory, Walter A; Jackson, Graham H; Irving, Julie A; Pratt, Guy; Fegan, Chris; Fenton, James AL; Neben, Kai; Hoffmann, Per; Nöthen, Markus M; Mühleisen, Thomas W; Eisele, Lewin; Ross, Fiona M; Straka, Christian; Einsele, Hermann; Langer, Christian; Dörner, Elisabeth; Allan, James M; Jauch, Anna; Morgan, Gareth J; Hemminki, Kari; Houlston, Richard S; Goldschmidt, Hartmut

    2016-01-01

    To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 cases and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P=8.70x10-14), 6p21.33 (rs2285803, PSORS1C2; P= 9.67x10-11), 17p11.2 (rs4273077, TNFRSF13B; P=7.67x10-9) and 22q13.1 (rs877529, CBX7; P=7.63x10-16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy and insight into the biological basis of predisposition. PMID:23955597

  2. Mapping Breakpoints of Complex Chromosome Rearrangements Involving a Partial Trisomy 15q23.1-q26.2 Revealed by Next Generation Sequencing and Conventional Techniques.

    Directory of Open Access Journals (Sweden)

    Qiong Pan

    Full Text Available Complex chromosome rearrangements (CCRs, which are rather rare in the whole population, may be associated with aberrant phenotypes. Next-generation sequencing (NGS and conventional techniques, could be used to reveal specific CCRs for better genetic counseling. We report the CCRs of a girl and her mother, which were identified using a combination of NGS and conventional techniques including G-banding, fluorescence in situ hybridization (FISH and PCR. The girl demonstrated CCRs involving chromosomes 3 and 8, while the CCRs of her mother involved chromosomes 3, 5, 8, 11 and 15. HumanCytoSNP-12 Chip analysis identified a 35.4 Mb duplication on chromosome 15q21.3-q26.2 in the proband and a 1.6 Mb microdeletion at chromosome 15q21.3 in her mother. The proband inherited the rearranged chromosomes 3 and 8 from her mother, and the duplicated region on chromosome 15 of the proband was inherited from the mother. Approximately one hundred genes were identified in the 15q21.3-q26.2 duplicated region of the proband. In particular, TPM1, SMAD6, SMAD3, and HCN4 may be associated with her heart defects, and HEXA, KIF7, and IDH2 are responsible for her developmental and mental retardation. In addition, we suggest that a microdeletion on the 15q21.3 region of the mother, which involved TCF2, TCF12, ADMA10 and AQP9, might be associated with mental retardation. We delineate the precise structures of the derivative chromosomes, chromosome duplication origin and possible molecular mechanisms for aberrant phenotypes by combining NGS data with conventional techniques.

  3. Evaluation of automated attenuation-based tube current adaptation for coronary calcium scoring in MDCT in a cohort of 262 patients

    International Nuclear Information System (INIS)

    The aim of our study was to evaluate attenuation-based tube current adaptation in coronary calcium scoring using ECG-gated multi-detector-row CT (MDCT). A total of 262 patients underwent non-enhanced cardiac MDCT. Group 1 was scanned using a standard protocol with 120 kV and 150 mAseff. Groups 2-4 were scanned using an attenuation-based dose-adaptation template (CARE Dose) with different effective reference mAs settings (150, 180, 210 mAseff). Body-mass index (BMI) and CT-dose index values were calculated for each patient. Image noise and subjective image quality were assessed. Regression analysis was performed, and the variation coefficient of image noise was determined. Compared to the standard scan protocol a dose reduction of 31.1% for group 2 and 20.1% for group 3 was observed. Measurement variation of image noise was smaller for the attenuation-based dose adaptation protocols (group 2-4) (16.2-17.1%) compared to the standard scan protocol (32.3%). Regression analysis of groups 2-4 showed better correlation with improved dose usage based on BMI (all P ≤ 0.001). Median image quality was ''excellent'' in groups 2-4 and ''good'' in group 1. Automated attenuation-based tube current adaptation in coronary calcium scoring is technically feasible, can decrease patient dose, and reduces variation in image noise as a sign of improved dose usage. (orig.)

  4. A novel locus for alopecia with mental retardation syndrome (APMR2) maps to chromosome 3q26.2-q26.31.

    Science.gov (United States)

    Wali, A; John, P; Gul, A; Lee, K; Chishti, M S; Ali, G; Hassan, M J; Leal, S M; Ahmad, W

    2006-09-01

    Congenital alopecia may occur either alone or in association with ectodermal and other abnormalities. On the bases of such associations, several different syndromes featuring congenital alopecia can be distinguished. Alopecia with mental retardation syndrome (APMR) is a rare autosomal recessive disorder, clinically characterized by total or partial hair loss and mental retardation. In the present study, a five-generation Pakistani family with multiple affected individuals with APMR was ascertained. Patients in this family exhibited typical features of APMR syndrome. The disease locus was mapped to chromosome 3q26.2-q26.31 by carrying out a genome scan followed by fine mapping. A maximum two-point logarithm of odds (LOD) score of 2.93 at theta=0.0 was obtained at markers D3S3053 and D3S2309. Multipoint linkage analysis resulted in a maximum LOD score of 4.57 with several markers, which supports the linkage. The disease locus was flanked by markers D3S1564 and D3S2427, which corresponds to 9.6-cM region according to the Rutgers combined linkage-physical map of the human genome (build 35) and contains 5.6 Mb. The linkage interval of the APMR locus identified here does not overlap with the one described previously; therefore, this locus has been designated as APMR2.

  5. Microdeletion 15q26.2qter and Microduplication 18q23 in a Patient with Prader-Willi-Like Syndrome: Clinical Findings.

    Science.gov (United States)

    Dello Russo, Patrizia; Demori, Eliana; Sechi, Annalisa; Passon, Nadia; Romagno, Daniela; Gnan, Chiara; Zoratti, Raffaele; Damante, Giuseppe

    2016-01-01

    The small interstitial deletion in the long arm of chromosome 15 causing Prader-Willi/Angelman syndrome is well known, whereas cases that report terminal deletions in 15q in association with the Prader-Willi-like phenotype are very rare. By using GTG-banding analysis, metaphase FISH, MLPA analysis, and genome-wide array CGH, we detected an unbalanced translocation involving a microdeletion of the distal part of 15q and a microduplication of the distal part of 18q. The unbalanced translocation was found in a boy that was referred with clinical suspicion of Prader-Willi syndrome. In the 15q-deleted region, 23 genes have been identified, and 13 of them are included in the OMIM database. Among these, the deleted IGFR1, MEF2A, CHSY1, and TM2D3 genes could contribute to the patient's phenotype. Seven genes are included in the duplicated chromosome segment 18q, but only one (CTDP1) is present in the OMIM database. We suggest that the deleted chromosome segment 15q26.2qter may be responsible for the phenotype of our case and may also be a candidate locus of Prader-Willi-like syndrome. PMID:27160288

  6. Evaluation of the curative effect of hysteroscopy combined with laparoscopy for diagnosis and treatment of 262 cases with female infertility%宫腹腔镜联合手术诊治女性不孕症262例疗效评价

    Institute of Scientific and Technical Information of China (English)

    刘涛

    2012-01-01

    目的:探讨宫腹腔镜联合手术在诊治女性不孕症中的临床价值.方法:回顾性分析2004年1月~ 2010年1月因不孕症接受宫腹腔镜联合手术诊治的患者262例,镜下评估不孕症的病因,观察术后患者输卵管通畅情况和妊娠率.结果:262例不孕症患者中,盆腔病变107例,宫腔病变90例,同时存在盆腔和宫腔病变65例.慢性盆腔炎与盆腔粘连是引起女性不孕症的首位病因,主要引起继发不孕.子宫内膜异位症、多囊卵巢综合征也是引起女性不孕症的重要原因,主要引起原发不孕.术前输卵管通畅率为74.13%,术后输卵管通畅率为91.11%.术后随访1~24月,223例获随访,随访率为85.11%.术后妊娠135例,妊娠率为51.53%,异位妊娠14例(5.34%),流产10例(3.82%).结论:宫腹腔镜联合手术在诊治女性不孕症方面能够优势互补,在诊断的同时给予治疗,漏检率低、创伤小、并发症少,对女性不孕症的诊治有重要的临床价值.%Objective; To explore the clinical value of hysteroscopy combined with laparoscopy for diagnosis and treatment of cases with female infertility. Methods: A total of 262 patients with infertility who underwent hysteroscopy combined with laparoscopy for diagnosis and treatment in the hospital from January 2004 to January 2010 were analyzed retrospectively, the causes of infertility were assessed under hysteroscope combined with laparoscope, the patency of Fallopian tubes and pregnancy rate of the patients after operation were observed. Results; Among 262 patients with infertility, 107 patients were found with pelvic cavity lesions, 90 patients were found with uterine cavity lesions, and 65 patients were found with pelvic cavity lesions combined with uterine cavity lesions. Chronic pelvic inflammatory disease and pelvic adhesion mainly induced secondary infertility, which were the first causes of female infertility. Endometriosis and polycys-tic ovarian syndrome were

  7. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.

    Directory of Open Access Journals (Sweden)

    Kanae Ando

    2016-03-01

    Full Text Available Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD. β-amyloid (Aβ lies upstream of abnormal tau behavior, including detachment from microtubules, phosphorylation at several disease-specific sites, and self-aggregation into toxic tau species in AD brains. To prevent the cascade of events leading to neurodegeneration in AD, it is essential to elucidate the mechanisms underlying the initial events of tau mismetabolism. Currently, however, these mechanisms remain unclear. In this study, using transgenic Drosophila co-expressing human tau and Aβ, we found that tau phosphorylation at AD-related Ser262/356 stabilized microtubule-unbound tau in the early phase of tau mismetabolism, leading to neurodegeneration. Aβ increased the level of tau detached from microtubules, independent of the phosphorylation status at GSK3-targeted SP/TP sites. Such mislocalized tau proteins, especially the less phosphorylated species, were stabilized by phosphorylation at Ser262/356 via PAR-1/MARK. Levels of Ser262 phosphorylation were increased by Aβ42, and blocking this stabilization of tau suppressed Aβ42-mediated augmentation of tau toxicity and an increase in the levels of tau phosphorylation at the SP/TP site Thr231, suggesting that this process may be involved in AD pathogenesis. In contrast to PAR-1/MARK, blocking tau phosphorylation at SP/TP sites by knockdown of Sgg/GSK3 did not reduce tau levels, suppress tau mislocalization to the cytosol, or diminish Aβ-mediated augmentation of tau toxicity. These results suggest that stabilization of microtubule-unbound tau by phosphorylation at Ser262/356 via the PAR-1/MARK may act in the initial steps of tau mismetabolism in AD pathogenesis, and that such tau species may represent a potential therapeutic target for AD.

  8. Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Nanjundan, Meera; Cheng, Kwai Wa; Zhang, Fan; Lahad, John; Kuo, Wen-Lin; Schmandt, Rosemarie; Smith-McCune, Karen; Fishman, David; Gray, Joe W.; Mills, Gordon B.

    2008-07-18

    High-resolution array comparative genomic hybridization of 235 serous epithelial ovarian cancers demonstrated a regional increase at 3q26.2 encompassing SnoN/SkiL, a coregulator of SMAD/TGF{beta} signaling. SnoN RNA transcripts were elevated in {approx}80% of advanced stage serous epithelial ovarian cancers. In both immortalized normal (TIOSE) and ovarian carcinoma cell lines (OVCA), SnoN RNA levels were increased by TGF{beta} stimulation and altered by LY294002 and JNK II inhibitor treatment suggesting that the PI3K and JNK signaling pathways may regulate TGF{beta}-induced increases in SnoN RNA. In TIOSE, SnoN protein levels were reduced 15min post TGF{beta}-stimulation, likely by proteosome-mediated degradation. In contrast, in OVCA, SnoN levels were elevated 3h post-stimulation potentially as a result of inhibition of the proteosome. To elucidate the role of SnoN in ovarian tumorigenesis, we explored the effects of both increasing and decreasing SnoN levels. In both TIOSE and OVCA, SnoN siRNA decreased cell growth between 20 and 50% concurrent with increased p21 levels. In TIOSE, transient expression of SnoN repressed TGF{beta} induction of PAI-1 promoters with little effect on the p21 promoter or resultant cell growth. In contrast to the effects of transient expression, stable expression of SnoN in TIOSE led to growth arrest through induction of senescence. Collectively, these results implicate SnoN levels in multiple roles during ovarian carcinogenesis: promoting cellular proliferation in ovarian cancer cells and as a positive mediator of cell cycle arrest and senescence in non-transformed ovarian epithelial cells.

  9. MOA-2011-BLG-262Lb: A sub-Earth-mass moon orbiting a gas giant primary or a high velocity planetary system in the galactic Bulge

    International Nuclear Information System (INIS)

    We present the first microlensing candidate for a free-floating exoplanet-exomoon system, MOA-2011-BLG-262, with a primary lens mass of M host ∼ 4 Jupiter masses hosting a sub-Earth mass moon. The argument for an exomoon hinges on the system being relatively close to the Sun. The data constrain the product ML πrel where ML is the lens system mass and πrel is the lens-source relative parallax. If the lens system is nearby (large πrel), then ML is small (a few Jupiter masses) and the companion is a sub-Earth-mass exomoon. The best-fit solution has a large lens-source relative proper motion, μrel = 19.6 ± 1.6 mas yr–1, which would rule out a distant lens system unless the source star has an unusually high proper motion. However, data from the OGLE collaboration nearly rule out a high source proper motion, so the exoplanet+exomoon model is the favored interpretation for the best fit model. However, there is an alternate solution that has a lower proper motion and fits the data almost as well. This solution is compatible with a distant (so stellar) host. A Bayesian analysis does not favor the exoplanet+exomoon interpretation, so Occam's razor favors a lens system in the bulge with host and companion masses of Mhost=0.12−0.06+0.19 M⊙ and mcomp=18−10+28 M⊕, at a projected separation of a⊥=0.84−0.14+0.25 AU. The existence of this degeneracy is an unlucky accident, so current microlensing experiments are in principle sensitive to exomoons. In some circumstances, it will be possible to definitively establish the mass of such lens systems through the microlensing parallax effect. Future experiments will be sensitive to less extreme exomoons.

  10. Evaluation of automated attenuation-based tube current adaptation for coronary calcium scoring in MDCT in a cohort of 262 patients

    Energy Technology Data Exchange (ETDEWEB)

    Muehlenbruch, Georg; Hohl, Christian; Das, Marco; Wildberger, Joachim E.; Thomas, Christoph; Guenther, Rolf W. [University Hospital (RWTH) Aachen, Department of Diagnostic Radiology, Aachen (Germany); Suess, Christoph; Klotz, Ernst; Flohr, Thomas [Siemens Medical Solutions, Computed Tomography, Forchheim (Germany); Koos, Ralf [University Hospital (RWTH) Aachen, Department of Cardiology, Aachen (Germany); Mahnken, Andreas H. [RWTH-Aachen University, Applied Medical Engineering, Helmholtz Institute, Aachen (Germany)

    2007-07-15

    The aim of our study was to evaluate attenuation-based tube current adaptation in coronary calcium scoring using ECG-gated multi-detector-row CT (MDCT). A total of 262 patients underwent non-enhanced cardiac MDCT. Group 1 was scanned using a standard protocol with 120 kV and 150 mAs{sub eff}. Groups 2-4 were scanned using an attenuation-based dose-adaptation template (CARE Dose) with different effective reference mAs settings (150, 180, 210 mAs{sub eff}). Body-mass index (BMI) and CT-dose index values were calculated for each patient. Image noise and subjective image quality were assessed. Regression analysis was performed, and the variation coefficient of image noise was determined. Compared to the standard scan protocol a dose reduction of 31.1% for group 2 and 20.1% for group 3 was observed. Measurement variation of image noise was smaller for the attenuation-based dose adaptation protocols (group 2-4) (16.2-17.1%) compared to the standard scan protocol (32.3%). Regression analysis of groups 2-4 showed better correlation with improved dose usage based on BMI (all P {<=} 0.001). Median image quality was ''excellent'' in groups 2-4 and ''good'' in group 1. Automated attenuation-based tube current adaptation in coronary calcium scoring is technically feasible, can decrease patient dose, and reduces variation in image noise as a sign of improved dose usage. (orig.)

  11. CHLOROPHYLL A and PHAEOPIGMENTS profile data collected in the North Atlantic Ocean on the ENDEAVOR cruises EN259, EN262 and others as part of the GB project from 1995-01-11 to 1995-06-16 (NODC Accession 0104395)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0104395 includes profile and biological data collected aboard the ENDEAVOR during cruises EN259, EN262, EN264, EN266 and EN267II in the North...

  12. MOA-2011-BLG-262Lb: A sub-Earth-mass moon orbiting a gas giant primary or a high velocity planetary system in the galactic Bulge

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, D. P. [Department of Physics, University of Notre Dame, 225 Nieuwland Science Hall, Notre Dame, IN 46556 (United States); Batista, V. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Bond, I. A.; Ling, C. H. [Institute of Natural and Mathematical Sciences, Massey University, Auckland 0745 (New Zealand); Bennett, C. S. [Department of Physics, Massachussets Institute of Technology, Cambridge, MA 02139 (United States); Suzuki, D.; Koshimoto, N. [Department of Earth and Space Science, Osaka University, Osaka 560-0043 (Japan); Beaulieu, J.-P. [UPMC-CNRS, UMR 7095, Institut d' Astrophysique de Paris, 98bis Boulevard Arago, F-75014 Paris (France); Udalski, A. [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Donatowicz, J. [Technische Universität Wien, Wieder Hauptst. 8-10, A-1040 Vienna (Austria); Bozza, V. [Dipartimento di Fisica, Università di Salerno, Via Ponte Don Melillo 132, I-84084 Fisciano (Italy); Abe, F.; Fukunaga, D.; Itow, Y.; Masuda, K.; Matsubara, Y.; Muraki, Y. [Solar-Terrestrial Environment Laboratory, Nagoya University, Nagoya 464-8601 (Japan); Botzler, C. S.; Freeman, M. [Department of Physics, University of Auckland, Private Bag 92-019, Auckland 1001 (New Zealand); Fukui, A., E-mail: bennett@nd.edu [Okayama Astrophysical Observatory, National Astronomical Observatory of Japan, Okayama 719-0232 (Japan); Collaboration: MOA Collaboration; PLANET Collaboration; μFUN Collaboration; OGLE Collaboration; RoboNet Collaboration; and others

    2014-04-20

    We present the first microlensing candidate for a free-floating exoplanet-exomoon system, MOA-2011-BLG-262, with a primary lens mass of M {sub host} ∼ 4 Jupiter masses hosting a sub-Earth mass moon. The argument for an exomoon hinges on the system being relatively close to the Sun. The data constrain the product M{sub L} π{sub rel} where M{sub L} is the lens system mass and π{sub rel} is the lens-source relative parallax. If the lens system is nearby (large π{sub rel}), then M{sub L} is small (a few Jupiter masses) and the companion is a sub-Earth-mass exomoon. The best-fit solution has a large lens-source relative proper motion, μ{sub rel} = 19.6 ± 1.6 mas yr{sup –1}, which would rule out a distant lens system unless the source star has an unusually high proper motion. However, data from the OGLE collaboration nearly rule out a high source proper motion, so the exoplanet+exomoon model is the favored interpretation for the best fit model. However, there is an alternate solution that has a lower proper motion and fits the data almost as well. This solution is compatible with a distant (so stellar) host. A Bayesian analysis does not favor the exoplanet+exomoon interpretation, so Occam's razor favors a lens system in the bulge with host and companion masses of M{sub host}=0.12{sub −0.06}{sup +0.19} M{sub ⊙} and m{sub comp}=18{sub −10}{sup +28} M{sub ⊕}, at a projected separation of a{sub ⊥}=0.84{sub −0.14}{sup +0.25} AU. The existence of this degeneracy is an unlucky accident, so current microlensing experiments are in principle sensitive to exomoons. In some circumstances, it will be possible to definitively establish the mass of such lens systems through the microlensing parallax effect. Future experiments will be sensitive to less extreme exomoons.

  13. Determination of the sensitization of two coatings by steel welding 308l by the EPR-Dl and Astm A-262 practice A techniques; Determinacion de la sensibilizacion de dos revestimientos por soldadura de acero 308L por las tecnicas EPR-DL y ASTM A-262 practica A

    Energy Technology Data Exchange (ETDEWEB)

    Arganis J, C. R.; Zenteno S, J. C.; Robles F, J. L.; Rodriguez M, E.; Vazquez P, A., E-mail: carlos.arganis@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    A stainless steel 308l coating was deposited by the shielded metal arc welding (SMAW) on steel A36 with a thickness of 4.726 mm in three layers. The sensitization was measured with the technique of Electrochemical Potentiodynamic Reactivation of Double-loop (EPR-Dl), using a portable cell and other of conventional window. The standard Astm A-262, practice A was used to verify the sensitization values. Two samples were used, a welding on a plate of 323 x 172 x 76.2 mm and the second welding on the end of a plate of 12.7 mm of thickness and 280 mm of longitude, with a post-welding process with gas tungsten arc welding (GTAW) with electrode ERNiCr{sub 3} and a process SMAW with electrode ENICRFe{sub 3}. The coating on the plate showed low values of sensitization grade (DOS) in all the points, indicating a very quick heat extraction and an inter dendritic structure type step. The second sample presented DOS values that are related with a structure of low sensitization and the influence of the heat of the post-welding process and a structure of recrystallized grains. (Author)

  14. Studies on Antigenic Peptides of Glutathione S-Transferase Sm26/2 of Schistosoma Mansoni%曼氏血吸虫谷胱甘肽S-转移酶Sm26/2的抗原肽研究

    Institute of Scientific and Technical Information of China (English)

    许家喜; 蔡孟深

    1998-01-01

    在计算机辅助下,应用Goldkey和PC-Gene程序,根据新报道的曼氏血吸虫谷胱甘肽S-转移酶Sm26/2的氨基酸序列,进行亲水性、柔韧性、可接近性、电荷分布和二级结构分析,预测出6个抗原肽,并用固相法进行了合成.经Dot-ELISA法测定,其中的2个对抗日本血吸虫免疫球蛋白多克隆抗体(抗-Sj-IgG-PcAb)显示出较好的抗原性,1个对抗血吸虫表膜单克隆抗体(A6McAb)显示出较好的抗原性,可作为抗血吸虫病合成多肽疫苗的候选肽段.

  15. Phase transition and magnetocaloric effect of Ni55.2Mn18.6Ga26.2-xGdx (x=0, 0.05, 0.15) alloys

    Institute of Scientific and Technical Information of China (English)

    BAO; Bo

    2009-01-01

    Phase transition process and magnetic entropy change -ΔS of Ni55.2Mn18.6Ga26.2-xGdx(x=0, 0.05, 0.15) alloys were studied.Ni55.2Mn18.6Ga26.2-xGdx(x=0, 0.05, 0.15) alloys still underwent simultaneous structural and magnetic transitions and transform from ferro-magnetic martensitic phase to paramagnetic austenitic phase during heating. Under a field of 2 T, the maximum magnetic entropy change -ΔSM of Ni55.2Mn18.6Ga26.15Gd0.05 alloy was 7.7 J/kg.K at 317 K during heating and 8.6 J/kg.K at 314 K during cooling while it was 11.8 J/kg.K at 317 K in Ni55.2Mn18.6Ga26.05Gd0.15alloy during heating.

  16. Clinical, Cytogenetic, and Biochemical Analyses of a Family with a t(3;13(q26.2;p11.2: Further Delineation of 3q Duplication Syndrome

    Directory of Open Access Journals (Sweden)

    M. Abreu-González

    2013-01-01

    Full Text Available Chromosomal abnormalities that result in genomic imbalances are a major cause of congenital and developmental anomalies. Partial duplication of chromosome 3q syndrome is a well-described condition, and the phenotypic manifestations include a characteristic facies, microcephaly, hirsutism, synophrys, broad nasal bridge, congenital heart disease, genitourinary disorders, and mental retardation. Approximately 60%–75% of cases are derived from a balanced translocation. We describe a family with a pure typical partial trisomy 3q syndrome derived from a maternal balanced translocation t(3;13(q26.2;p11.2. As the chromosomal rearrangement involves the short arm of an acrocentric chromosome, the phenotype corresponds to a pure trisomy 3q26.2-qter syndrome. There are 4 affected individuals and several carriers among three generations. The report of this family is relevant because there are few cases of pure duplication 3q syndrome reported, and the cases described here contribute to define the phenotype associated with the syndrome. Furthermore, we confirmed that the survival until adulthood is possible. This report also identified the presence of glycosaminoglycans in urine in this family, not related to the chromosomal abnormality or the phenotype.

  17. 262例妊娠期糖代谢异常病例的发病相关因素分析%Related factors of glycomebabolism disorder during pregnancy

    Institute of Scientific and Technical Information of China (English)

    赵娟利; 朱仁祝; 史敏尔; 陈爱娥

    2012-01-01

    Objective To understand the related factors of glycomebabolism disorder during pregnancy in Yuyao. Methods The analysis was conducted on the related factors between 262 cases of abnormal glucose metabolism during pregnancy (case group) and 189 cases (control group), with u test andχ2 test. Results The difference on age between case group and control group was statistical significant. The differences in women aged 29 years. Glycomebabolism disorder occuned in less number in women aged ≥35 and <25 years. Gestational impaired glucose tolerance (GIGT) was more likely to occur in the women with low body mass index (BMI) and GDM was more likely to occur in overweight women. Low education level was the risk factor of glycomebabolism disorder during pregnancy, but the high education level was the protective factor. Glycomebabolism disorder during pregnancy was prone to occur in women with more than once pregnancy/delivery and in those with mild work intensity.%目的 了解浙江省余姚市妊娠期糖代谢异常的相关发病因素.方法 对2009-2011年3月262例妊娠期糖代谢异常病例与189例对照组在相关因素方面进行比较,统计学方法采用u检验、x2检验.结果 病例组与对照组比较年龄均值差异有统计学意义;年龄<25岁与≥35岁经x2检验差异有统计学意义(P<0.05);两组文化程度小学及以下学历与大专及以上学历差异有统计学意义(P<0.05);孕1次和孕3次及以上比较、初产妇与经产妇比较差异有统计学意义(P均<0.01);两组在劳动强度上比较,极轻体力劳动差异有统计学意义(P<0.05);两组在高危因素发生上差异有统计学意义(P<0.05).结论 年龄均值>29岁GDM发生率增高,特别是年龄在≥35岁:<25岁孕妇不易发生糖代谢异常.病例组中妊娠期糖耐量受损组(GIGT)与GDM组比较,低体质指数者更易发生GIGT,而超重者更易发生妊娠期糖尿病.文化程度上,小学及文盲是GDM的高

  18. “The Third Party Mode”:Public Opinion Construction and Guiding Strategy of zaobao. com Case Involving Violence and Terrorism in Xinjiang ---Analysis Based on Knowledge Mining of 262 Reports%联合早报网涉疆暴恐案的舆论构建及引导策略*--基于262篇报道的知识挖掘分析

    Institute of Scientific and Technical Information of China (English)

    吴锋; 季丹

    2016-01-01

    [目的/意义]近年来,新疆是我国反恐斗争的主战场,也是中外舆论博弈的焦点。分析联合早报网涉疆暴恐报道的“第三方模式”,试图探索涉疆暴恐案舆论引导新路径。[方法/过程]选取联合早报网自2009年新疆“7·5事件”爆发至2015年底间发生的所有涉疆暴恐案相关报道262篇,依据构建的指标体系,进行了详细的内容分析和统计分析。[结果/结论]研究表明,联合早报网在涉疆报道中注重平衡,善于讲“两面理”,在坚持客观报道的前提下,给多元利益方发声机会,不规避批评声音;重视舆论领袖的示范效应,引导知名媒体人或专家学者发布解释性报道;善于调动受众参与,及时捕捉受众的信息需求,达到了互动传播的良好效果。%Purpose/Significance] In recent years, Xinjiang has become the main battlefield of violent terrorist activities in mainland China, and the focus of the game between Chinese and foreign public opinions. Of them, there exists a"binary opposition" structure in-volving the violence and terror cases in Xinjiang:one side is Chinese mainland media's supporting framework, the other side is the critical framework represented by western developed countries. This kind of binary structure of public opinion not only interferes with China's anti-terrorist activities, but also has a negative impact on the international community. [ Method/Process] Based on 262 reports in zaobao. com, this study analyses"the third party model", which involves violent terrorist reports in Xinjiang, and explores a new path for the im-proved public opinion guidance. [ Result/Conclusion] The study finds out that related reports of Xinjiang on the Lianhe Zaobao website focus on balanced coverage, being good at reporting from both sides:on the premise of objective reporting, it provides opportunities for multi-interest bodies to utter their voice, without evading the question or

  19. 49 CFR 262.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... rehabilitation; (3) Acquisition of rights-of-way; (4) Relocation assistance, acquisition of replacement housing sites, and acquisition and rehabilitation, relocation, and construction of replacement housing; (5.... Relocation means moving a rail line vertically or laterally to a new location. Vertical relocation refers...

  20. 29 CFR 1910.262 - Textiles.

    Science.gov (United States)

    2010-07-01

    .... (14) Gill box. A gill box is a machine used in the worsted system of manufacturing yarns. Its function... in § 1910.6. (7) Identification of piping systems. Identification of piping systems shall conform to... enclosed hot air dryer, and a beaming end for finding the yarn on the loom beams. (35) Solvent...

  1. 7 CFR 1822.262 - Objective.

    Science.gov (United States)

    2010-01-01

    ... PRIMARILY FOR REAL ESTATE PURPOSES RURAL HOUSING LOANS AND GRANTS Rural Housing Site Loan Policies... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... private nonprofit organizations interested in providing sites for housing, to acquire and develop land...

  2. 40 CFR 262.34 - Accumulation time.

    Science.gov (United States)

    2010-07-01

    ... requirements of subparts I, AA, BB, and CC of 40 CFR part 265; and/or (ii) In tanks and the generator complies with the applicable requirements of subparts J, AA, BB, and CC of 40 CFR part 265 except §§ 265.197(c) and 265.200; and/or (iii) On drip pads and the generator complies with subpart W of 40 CFR part...

  3. 43 CFR 26.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... grant program. Within the Department of Agriculture, the YCC program is administered by the Forest... simple by a State or political subdivision thereof or over which a State or political subdivision thereof... public lands and waters administered by a State or political subdivision thereof under agreement with...

  4. 39 CFR 262.4 - Records.

    Science.gov (United States)

    2010-07-01

    ..., including electronic data, developed or received by the Postal Service in connection with the transaction of... National Archives and Records Administration as having sufficient historical or other value to warrant continued preservation. (All other records are considered temporary and must be scheduled for disposal.)...

  5. 40 CFR 262.58 - International agreements.

    Science.gov (United States)

    2010-07-01

    ... and Mexico are considered OECD member countries only for the purpose of transit. (b) Any person who...) For the purposes of subpart H of this part, Canada and Mexico are considered OECD Member countries... universal waste management standards of 40 CFR Part 273, or subject to State requirements analogous to...

  6. 37 CFR 262.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...) Monies and other consideration (including without limitation customer acquisition fees) from audio or... a different page than the page/location where a potential customer responds to a “buy button” or... the avoidance of doubt, any entity that sells a third-party product, whether or not bearing...

  7. 18 CFR 284.262 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... to transport natural gas under subpart B, C, or G of this part. Projected level of service means the... natural gas sold, transported, or exchanged in an emergency natural gas transaction. Emergency natural gas... OF ENERGY OTHER REGULATIONS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES......

  8. 12 CFR 26.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ...) The term management official does not include: (i) A person whose management functions relate exclusively to the business of retail merchandising or manufacturing; (ii) A person whose management functions... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS §...

  9. 40 CFR 262.41 - Biennial report.

    Science.gov (United States)

    2010-07-01

    ... generator who ships any hazardous waste off-site to a treatment, storage or disposal facility within the... disposal facility within the United States; (5) A description, EPA hazardous waste number (from 40 CFR part... the provisions of 40 CFR parts 270, 264, 265, 266, and 267. Reporting for exports of hazardous...

  10. 40 CFR 262.200 - Definitions for this subpart.

    Science.gov (United States)

    2010-07-01

    .... Formal written affiliation agreement for a non-profit research institute means a written document that... an organization that conducts research as its primary function and files as a non-profit organization... Education. Eligible academic entity means a college or university, or a non-profit research institute...

  11. 30 CFR 206.262 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... either a straight-line depreciation method based on the life of equipment or on the life of the reserves... claim a transportation allowance by reporting it as a separate line entry on the Form MMS-4430. (2) In... reporting it as a separate line entry on the Form MMS-4430. When necessary or appropriate, MMS may direct...

  12. Total laparoscopic hysterectomy : retrospective analysis of 262 cases

    OpenAIRE

    Silva, Cristina Nogueira; Ribeiro, Samuel Santos; Barata, Sónia; Alho, Conceição; Osório, Filipa; Jorge, Carlos Calhaz

    2014-01-01

    Introdução: A histerectomia é a cirurgia ginecológica major mais frequentemente realizada nos países desenvolvidos, considerando- -se três principais vias de abordagem: vaginal, abdominal e laparoscópica. Apesar de múltiplas vantagens, a histerectomia totalmente laparoscópica tem-se associado a controvérsia relativamente à taxa de complicações. Objectivos: Análise da nossa casuística de histerectomia totalmente laparoscópica e avaliação da taxa de complicações. Material e Métodos:...

  13. Dicty_cDB: VFL262 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available QQQQQQQQ QQQQQQQQQQQNPQPQQQXPPPPPPPPQQQQQHQQQQQQQQQQHPTTTXXXTTT--- ---atttttttxxtpttxaxtxaatttnrrmgrtlkngvasy*dixsyxvly*xvxrf...xnxssnhnqqkngshpqkwxckllrhqxlxxlilxsxqvlxk lrxpnxrfliy Homology vs CSM-cDNA Score E Sequences producing sign

  14. Dicty_cDB: SHL262 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available U72236.1 Dictyostelium discoideum ModA (modA) gene, complete cds. 1154 0.0 1 DV771667 |DV771667.1 McClintock5_D06.ab1 Homarus... EST library project Homarus americanus cDNA clone McClintock5_D06.ab1, mRNA sequence. 48 1

  15. Dicty_cDB: VSF262 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ALCES mitochondrial D-loop, complete sequence. 36 0.068 2 BQ507669 |BQ507669.2 EST615084 Generation...sum cDNA clone cSTS20D12 5' sequence, mRNA sequence. 32 0.49 3 BQ507668 |BQ507668.1 EST615083 Generation

  16. 40 CFR 60.262 - Standard for particulate matter.

    Science.gov (United States)

    2010-07-01

    ..., silicomanganese, calcium carbide, ferrochrome silicon, ferromanganese silicon, or silvery iron is being produced... kg/MW-hr (0.99 lb/MW-hr) while silicon metal, ferrosilicon, calcium silicon, or...

  17. 37 CFR 262.6 - Verification of statements of account.

    Science.gov (United States)

    2010-07-01

    ... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES RATES AND TERMS FOR CERTAIN ELIGIBLE... procedure, unless it is finally determined that there was an underpayment of 10% or more, in which case...

  18. 37 CFR 262.7 - Verification of royalty payments.

    Science.gov (United States)

    2010-07-01

    ... COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES RATES AND TERMS FOR CERTAIN ELIGIBLE... underpayment of 10% or more, in which case the Designated Agent shall, in addition to paying the amount of...

  19. 40 CFR 180.262 - Ethoprop; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... Cabbage 0.02 Corn, field, forage 0.02 Corn, field, grain 0.02 Corn, field, stover 0.02 Corn, pop, grain 0.02 Corn, pop, stover 0.02 Corn, sweet, forage 0.02 Corn, sweet, kernel plus cob with husks removed 0.02 Corn, sweet, stover 0.02 Cucumber 0.02 Hop, dried cones 0.02 Peppermint, tops 0.02 Pineapple...

  20. 26 CFR 1.401(a)(26)-2 - Minimum participation rule.

    Science.gov (United States)

    2010-04-01

    ... one qualified separate line of business is treated as a separate plan from the portions of the same... qualified separate line of business). The rule in this paragraph (d)(6) does not apply to a plan that...

  1. 40 CFR 262.105 - What must be included in the laboratory environmental management plan?

    Science.gov (United States)

    2010-07-01

    ... policy, signed by the University's senior management, which must include commitments to regulatory...) Policies and procedures for managing environmental documents and records applicable to this Environmental... identified in the Environmental Management Plan must be informed of relevant policies, procedures or...

  2. 2.62 糖尿病患者胃电图的改变

    Institute of Scientific and Technical Information of China (English)

    张彤彦; 王雁; 丁燕

    2001-01-01

    目的糖尿病是严重危害人类健康的常见多发病,本研究应用胃电图(EGG)对糖尿病胃轻瘫患者和正常人进行检查,以了解糖尿病胃轻瘫患者胃电的改变.方法 1.研究对象:健康志愿者共12例,其中男性6例,女性6例,平均为41 .13±15.31岁.非胰岛素依赖型糖尿病(NIDDM)患者32例,均符合WHO的诊断标准,其中男性16例,女性16例,平均44.91±19.62岁.2. EGG记录方法:3个标准的银-氯化银电极 ,2个放于腹壁相当于胃投影的位置,E1置于剑突与脐连线中点,E2置于E1左侧4cm处,E3为参考电极,置于E2下4cm处.空腹状态记录胃电活动4h.用PC POLYGRAF HR台式高分辨三导胃电监测系统(Synectic Medical LTD瑞典)记录胃电,参数为:胃电频率百分比;平均频率 (PDF);平均振幅(PDP).结果对照组正常节律百分比为59.21±17.20%,胃动过缓为20.03±11. 69%,胃动过速为21.82±11.03%;糖尿病组分别为56.91±19.22%,25.03±11.74%, 18.15±8.66%.2组比较均无显著性差异.糖尿病组平均频率(PDF)为2.21±0.32cpm, 明显低于对照组2.79±0.46cpm(P<0.05);糖尿病组平均振幅(PDP)为1.65±0.36 db,明显低于对照组2.35±0.48db(P<0.05).结论非胰岛素依赖型糖尿病患者出现胃电节律紊乱,同时出现慢波振幅的下降.

  3. Complete Genome Sequence of the Solvent Producer Clostridium saccharobutylicum NCP262 (DSM 13864)

    OpenAIRE

    Poehlein, Anja; Gottschalk, Gerhard; Daniel, Rolf

    2013-01-01

    Clostridium saccharobutylicum was employed for the production of acetone and butanol in South Africa until the 1970s. The genome comprises a single replicon (5,107,814 bp) harboring all the genes necessary for solvent production and the degradation of various organic compounds, such as fructose, cellobiose, sucrose, and mannose.

  4. Complete Genome Sequence of the Solvent Producer Clostridium saccharobutylicum NCP262 (DSM 13864).

    Science.gov (United States)

    Poehlein, Anja; Hartwich, Katrin; Krabben, Preben; Ehrenreich, Armin; Liebl, Wolfgang; Dürre, Peter; Gottschalk, Gerhard; Daniel, Rolf

    2013-01-01

    Clostridium saccharobutylicum was employed for the production of acetone and butanol in South Africa until the 1970s. The genome comprises a single replicon (5,107,814 bp) harboring all the genes necessary for solvent production and the degradation of various organic compounds, such as fructose, cellobiose, sucrose, and mannose. PMID:24285650

  5. 40 CFR 262.21 - Manifest tracking numbers, manifest printing, and obtaining manifests.

    Science.gov (United States)

    2010-07-01

    ... ensure that numbers are tightly controlled and remain unique. In particular, the application must... application must also indicate how the printer will pre-print a unique number on each form (e.g., crash or... (i.e., manufacturer and grade of the manifest paper); (ii) Paper weight of each copy; (iii) Ink...

  6. 26 CFR 1.262-1 - Personal, living, and family expenses.

    Science.gov (United States)

    2010-04-01

    ... property by reason of casualty, etc. (5) Expenses incurred in traveling away from home (which include..., attorney's fees and other costs paid in connection with a divorce, separation, or decree for support are... of the other costs paid in connection with a divorce, legal separation, written separation...

  7. Rapid Coeval Black Hole and Host Galaxy Growth in MRC 1138-262: The Hungry Spider

    CERN Document Server

    Seymour, N; De Breuck, C; Barthel, P; Coia, D; Conversi, L; Dannerbauer, H; Dey, A; Dickinson, M; Drouart, G; Galametz, A; Greve, T R; Haas, M; Hatch, N; Ibar, E; Ivison, R; Jarvis, M; Kovacs, A; Kurk, J; Lehnert, M; Miley, G; Nesvadba, N; Rawlings, J I; Rettura, A; Rottgering, H; Rocca-Volmerange, B; Sanchez-Portal, M; Santos, J S; Stern, D; Stevens, J; Valtchanov, I; Vernet, J; Wylezalek, D

    2012-01-01

    We present a detailed study of the infrared spectral energy distribution of the high-redshift radio galaxy MRC 1138-26 at z = 2.156, also known as the Spiderweb Galaxy. By combining photometry from Spitzer, Herschel and LABOCA we fit the rest-frame 5-300 um emission using a two component, starburst and active galactic nucleus (AGN), model. The total infrared (8 - 1000 um) luminosity of this galaxy is (1.97+/-0.28)x10^13 Lsun with (1.17+/-0.27) and (0.79+/-0.09)x10^13 Lsun due to the AGN and starburst components respectively. The high derived AGN accretion rate of \\sim20% Eddington, and the measured star formation rate (SFR) of 1390pm150 Msun/yr, suggest that this massive system is in a special phase of rapid central black hole and host galaxy growth, likely caused by a gas rich merger in a dense environment. The accretion rate is sufficient to power both the jets and the previously observed large outflow. The high SFR and strong outflow suggest this galaxy could potentially exhaust its fuel for stellar growth...

  8. 37 CFR 262.4 - Terms for making payment of royalty fees and statements of account.

    Science.gov (United States)

    2010-07-01

    ... month in which the Licensee commences to do so. (e) Late payments. A Licensee shall pay a late fee of 0... the month; (2) The name, address, business title, telephone number, facsimile number, electronic...

  9. 36 CFR 262.1 - Rewards in connection with fire or property prosecutions.

    Science.gov (United States)

    2010-07-01

    ... grass upon the lands of the United States within the National Forest System or nearby. (2) Not exceeding... kindled or caused to be kindled a fire on lands of the United States within the National Forest System or... foliage. (b) A reward may be paid to the person or persons giving the information leading to such...

  10. CARPAL TUNNEL SYNDROME. ETIOLOGICAL, CLINICAL AND ELECTROPHYSIOLOGICAL ASPECTS OF 262 CASES

    Institute of Scientific and Technical Information of China (English)

    卢祖能; 汤晓芙

    1995-01-01

    Two hundred and sixty-two patients with carpal turmel syndrome (CTS) were analyzed retrospeetively. Results showed that middia-and older-age women were more apt to have CTS than men, and that the dominant hand was more frequently affected. Hormonal changes, repetitive and forceful movements, awkward positions of hand and wrist, and other factors may be associated with CTS. Typical clinical manifestations include pain and pareathesia in the median nerve territory, worsening at night or in the early morning, and being relieved by shaking the hand. Although the patients may localize the discomfort beyond the territory, sensory changes are variable and not entirely reliable. Conduction abnormalities often appeared selectively in the median nerve distal to the wriat in CTS. If the patient who is clinically suggestive of CTS shows normal conduction with conventional methods, palmar stimulation and inching technique is recommended. The diagnosis of CTS requires confirmation of illness history, symptoms and signs with objective electrodiagnostic tests.

  11. Osseous genioplasty in conjunction with bimaxillary orthognathic surgery: a review of 262 consecutive cases.

    Science.gov (United States)

    Posnick, J C; Choi, E; Chang, R P

    2016-07-01

    The purpose of this study was to evaluate the results of osseous genioplasty with bimaxillary orthognathic surgery. A retrospective consecutive case series of patients treated by a single surgeon between 2004 and 2013 was studied. All underwent Le Fort I, sagittal ramus osteotomies, septoplasty, inferior turbinate reduction, and osseous genioplasty. The outcome variables included the presenting chin dysmorphology, complications, and assessment of morphologic change. A Steiner analysis was completed for each subject's interval cephalogram. Two hundred sixty-two subjects met the inclusion criteria. Their mean age at operation was 25 (range 13-63) years. Chin osteotomy complications included one wound infection (0.4%), and two of the 1572 mandibular anterior teeth at risk sustained a pulpal injury. None of the subjects required revision. For subjects undergoing chin advancement, the mean change was +3.5 (range +3 to +6) mm. A majority also underwent counterclockwise rotation of the mandible (62%). For those undergoing chin lengthening, the mean change was +5 (range +3 to +12mm) mm, and for those undergoing vertical shortening, the mean change was -3.5 (range -3 to -7) mm. Osseous genioplasty is confirmed to be a safe method to reshape the chin. When osseous genioplasty is performed in conjunction with bimaxillary orthognathic surgery, only a modest horizontal change is required to achieve the preferred pogonion projection. PMID:26972157

  12. 40 CFR 262.104 - What are the minimum performance criteria?

    Science.gov (United States)

    2010-07-01

    ... words “laboratory waste” or with the chemical name of the contents. If the container is too small to... requirements for emergency response are: (1) Each University must post notification procedures, location of emergency response equipment to be used by laboratory workers and evacuation procedures; (2)...

  13. 45 CFR 262.4 - What happens if we determine that a State is subject to a penalty?

    Science.gov (United States)

    2010-10-01

    ... Federal loan; meet the basic MOE requirement; meet the Contingency Fund MOE requirement; expend additional... decision upholding the penalty, we will take the penalty and charge interest back to the date that...

  14. 47 CFR 25.262 - Licensing and domestic coordination requirements for 17/24 GHz BSS space stations.

    Science.gov (United States)

    2010-10-01

    ... degree or less from an appendix F location, and may operate at the maximum power flux density limits defined in §§ 25.208(c) and (w) of this part, without coordinating its power flux density levels with... BSS U.S. licensee or permittee that does not comply with the power flux-density limits set forth...

  15. Book Review - Water Resource Economics (MIT Press, Cambridge, 2006, 402 pages (hardback), ISBN 0-262-07267-X)

    OpenAIRE

    Robinson, Jackie

    2008-01-01

    As developed countries reach a state where decisions regarding the supply and distribution of water resources are made in an environment of a ‘mature water economy’, water managers are increasingly turning towards economics to assist them to plan future supply to meet increasing demand. Griffin approaches the management of water resources from a neoclassical economics perspective. In short, economic efficiency and competitive markets dominate the rationale for resource management. Griffin has...

  16. Susceptibility to Ulcerative Colitis and Genetic Polymorphisms of A251G SOD1 and C-262T CAT

    OpenAIRE

    El-Kheshen Gadier; Moeini Maryam; Saadat Mostafa

    2016-01-01

    Background: Reactive oxygen species can attack and damage almost every molecule found in living cells, including proteins, carbohydrates, lipids, and DNA. For this reason, their production is normally tightly controlled. Among the most important defenses against these radicals are the super oxide dismutase (SOD) enzymes and catalase (CAT). In creasing attention has been given to the role of reactive oxygen metabolites in the pathogenesis of ulcerative colitis (UC), which is defined as an idio...

  17. 40 CFR 262.212 - Making the hazardous waste determination at an on-site interim status or permitted treatment...

    Science.gov (United States)

    2010-07-01

    ....212 Making the hazardous waste determination at an on-site interim status or permitted treatment... hazardous waste permit or interim status as soon as it arrives in the on-site treatment, storage or disposal... permitted treatment, storage or disposal facility. (e) If the unwanted material is a hazardous waste,...

  18. 40 CFR 262.210 - Making the hazardous waste determination in the laboratory before the unwanted material is...

    Science.gov (United States)

    2010-07-01

    ... treatment, storage or disposal facility. (d) When hazardous waste is removed from the laboratory: (1) Large... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Making the hazardous waste...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Alternative Requirements for Hazardous...

  19. 37 CFR 262.3 - Royalty fees for public performances of sound recordings and for ephemeral recordings.

    Science.gov (United States)

    2010-07-01

    ... Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT ARBITRATION ROYALTY PANEL RULES AND PROCEDURES... Option—(A) Non-Music Programming. $0.000762 (0.0762¢) per Aggregate Tuning Hour for programming... experience in respect of partial performances. (ii) Aggregate Tuning Hour Option—(A) Non-Music...

  20. Dicty_cDB: Contig-U05481-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available taaaatataanttggntcaataaacttgantcaaagangantaataataataanttat 262 |||||||||||||||||||||||||||||||||||||||||||||...||||||||||||||| Sbjct: 203 antaaaatataanttggntcaataaacttgantcaaagangantaataataataanttat 262 Query: 263 atttt

  1. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    International Nuclear Information System (INIS)

    Several reactions producing odd-Z transactinide compound nuclei were studied with the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus at or near the same excitation energy with similar values of angular momentum via different nuclear reactions. In doing so, it can be determined if there is a preference in entrance channel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's 'Fusion By Diffusion' model is nearly identical for the two reactions. Additionally, because the same compound nucleus is produced, the exit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs; cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrance channel in these paired reactions. Charge equilibration immediately prior to fusion leading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi(52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35 ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki, Siwek-Wilcznska, and Wilczynski's 'Fusion By Diffusion' theory

  2. Odd-Z Transactinide Compound Nucleus Reactions Including the Discovery of 260Bh

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Sarah L. [Univ. of California, Berkeley, CA (United States)

    2008-01-01

    Several reactions producing odd-Z transactinide compound nuclei were studiedwith the 88-Inch Cyclotron and the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory. The goal was to produce the same compound nucleus ator near the same excitation energy with similar values of angular momentum via differentnuclear reactions. In doing so, it can be determined if there is a preference in entrancechannel, because under these experimental conditions the survival portion of Swiatecki, Siwek-Wilcznska, and Wilczynski's"Fusion By Diffusion" model is nearly identical forthe two reactions. Additionally, because the same compound nucleus is produced, theexit channel is the same. Four compound nuclei were examined in this study: 258Db, 262Bh, 266Mt, and 272Rg. These nuclei were produced by using very similar heavy-ion induced-fusion reactions which differ only by one proton in the projectile or target nucleus (e.g.: 50Ti + 209Bi vs. 51V + 208Pb). Peak 1n exit channel cross sections were determined for each reaction in each pair, and three of the four pairs' cross sections were identical within statistical uncertainties. This indicates there is not an obvious preference of entrancechannel in these paired reactions. Charge equilibration immediately prior to fusionleading to a decreased fusion barrier is the likely cause of this phenomenon. In addition to this systematic study, the lightest isotope of element 107, bohrium, was discovered in the 209Bi(52Cr,n) reaction. 260Bh was found to decay by emission of a 10.16 MeV alpha particle with a half-life of 35$+19\\atop{-9}$ ms. The cross section is 59 pb at an excitation energy of 15.0 MeV. The effect of the N = 152 shell is also seen in this isotope's alpha particle energy, the first evidence of such an effect in Bh. All reactions studied are also compared to model predictions by Swiatecki

  3. Corrigendum to "Development of ANFIS model for air quality forecasting and input optimization for reducing the computational cost and time" [Atmos. Environ. 128 (2016) 246-262

    Science.gov (United States)

    Prasad, Kanchan; Gorai, Amit Kumar; Goyal, Pramila

    2016-10-01

    In the paper entitled "Development of ANFIS model for air quality forecasting and input optimization for reducing the computational cost and time" the correlation coefficient values of O3 with the other parameters (shown in Table 4) were mistakenly written from some other results. But, the analyses were done based on the actual results. The actual values are listed in the revised Table 4.

  4. Investigation of xylose and arabinose metabolism in Clostridium acetobutylicum ATCC 824 and Clostridium saccharobutylicum NCP 262.

    OpenAIRE

    Lesiak, Justyna Maria

    2015-01-01

    Xylulose kinase (xylB) and arabinose kinase (araK) mutants of Clostridium acetobutylicum and C. saccharobutylicum were investigated and compared to wild type strains, regarding their abilities to metabolize xylose, arabinose and glucose. To create mutants in C. saccharobutylicum, an effective triparental mating system for DNA transfer was developed, and additionally restrictase mutants were constructed and characterized. Furthermore, growth and gene expression of C. acetobutylicum in continuo...

  5. Design of Production Test IP-262-A-11-FP -- Evaluation of projection fuel elements for use in ribbed process tubes -- Demonstration loading

    Energy Technology Data Exchange (ETDEWEB)

    Hodgson, W.H.; Hall, R.E.

    1959-06-29

    For several years, a major category of fuel element failures has been the side corrosion type, characterized by localized accelerated fuel element jacket corrosion. Since it has been demonstrated {sup 1} that misalignment of fuel elements in a process tube will produce flow patterns and accelerated corrosion, termed ``hot spots``, failure to align the fuel elements in process tubes is considered a contributing factor in the production of side corrosion failures. Preliminary testing of both self-supporting and ``bumper`` fuel elements is underway. Data on the self-supporting fuel elements have demonstrated that the bridge-rail projections have sufficient support strength, do not of themselves create a corrosion problem and in actuality probably eliminate any hot-spot areas. Although one tube of bumper fuel elements in KW Reactor {sup 3} has been discharged, data are not as yet available. Potentially, the most sever corrosion conditions exist during the summer months when reactor inlet temperatures are high. It is desirable then, provided bumper fuel elements limit hot- spot corrosion, to evaluate the bumper concept for large scale use possibly by the summer of 1960. To accomplish this, a demonstration loading of the bumper type fuel elements must be underway by about July, 1959. The purpose of this report is to present the design of a test to evaluate the fabrication process and irradiation performance of fuel elements having projections, which may prevent misalignment in ribbed process tubes and meet the aforementioned goals.

  6. Drayer's syndrome of mental retardation, microcephaly, short stature and absent phalanges is caused by a recurrent deletion of chromosome 15(q26.2 -> qter)

    NARCIS (Netherlands)

    Rump, P.; Dijkhuizen, T.; Sikkema-Raddatz, B.; Lemmink, H. H.; Vos, Y. J.; Verheij, J. B. G. M.; van Ravenswaaij, C. M. A.

    2008-01-01

    We reevaluated a unique family with two sibs who had a presumed autosomal recessively inherited syndrome characterized by mental retardation, microcephaly, short stature and absent phalanges. This family was originally described by Drayer et al. in 1977. Using modern molecular techniques, we demonst

  7. SU-E-J-262: Variability in Texture Analysis of Gynecological Tumors in the Context of An 18F-FDG PET Adaptive Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Nawrocki, J [Duke University Medical Physics Graduate Program, Durham, NC (United States); Chino, J; Das, S; Craciunescu, O [Duke University Medical Center, Durham, NC (United States)

    2015-06-15

    Purpose: This study examines the effect on texture analysis due to variable reconstruction of PET images in the context of an adaptive FDG PET protocol for node positive gynecologic cancer patients. By measuring variability in texture features from baseline and intra-treatment PET-CT, we can isolate unreliable texture features due to large variation. Methods: A subset of seven patients with node positive gynecological cancers visible on PET was selected for this study. Prescribed dose varied between 45–50.4Gy, with a 55–70Gy boost to the PET positive nodes. A baseline and intratreatment (between 30–36Gy) PET-CT were obtained on a Siemens Biograph mCT. Each clinical PET image set was reconstructed 6 times using a TrueX+TOF algorithm with varying iterations and Gaussian filter. Baseline and intra-treatment primary GTVs were segmented using PET Edge (MIM Software Inc., Cleveland, OH), a semi-automatic gradient-based algorithm, on the clinical PET and transferred to the other reconstructed sets. Using an in-house MATLAB program, four 3D texture matrices describing relationships between voxel intensities in the GTV were generated: co-occurrence, run length, size zone, and neighborhood difference. From these, 39 textural features characterizing texture were calculated in addition to SUV histogram features. The percent variability among parameters was first calculated. Each reconstructed texture feature from baseline and intra-treatment per patient was normalized to the clinical baseline scan and compared using the Wilcoxon signed-rank test in order to isolate variations due to reconstruction parameters. Results: For the baseline scans, 13 texture features showed a mean range greater than 10%. For the intra scans, 28 texture features showed a mean range greater than 10%. Comparing baseline to intra scans, 25 texture features showed p <0.05. Conclusion: Variability due to different reconstruction parameters increased with treatment, however, the majority of texture features showed significant changes during treatment independent of reconstruction effects.

  8. 40 CFR Appendix to Part 262 - Uniform Hazardous Waste Manifest and Instructions (EPA Forms 8700-22 and 8700-22A and Their...

    Science.gov (United States)

    2010-07-01

    ... operators of hazardous waste treatment, storage, and disposal facilities to complete this form (FORM 8700-22... treatment, storage, or disposal facilities to use the uniform hazardous waste manifest (EPA Form 8700-22... Group for each waste as identified in 49 CFR 172. Include technical name(s) and reportable...

  9. Automatic Parallelization of Scientific Application

    DEFF Research Database (Denmark)

    Blum, Troels

    performance gains. Scientists working with computer simulations should be allowed to focus on their field of research and not spend excessive amounts of time learning exotic programming models and languages. We have with Bohrium achieved very promising results by starting out with a relatively simple approach...

  10. Successful long-term growth hormone therapy in a girl with haploinsufficiency of the insulin-like growth factor-I receptor due to a terminal 15q26.2-> qter deletion detected by multiplex ligation probe amplification

    NARCIS (Netherlands)

    Walenkamp, Marie J. E.; Keizer-Schrama, Sabine M. P. F. de Muinck; de Mos, Marianne; Kalf, Margot E.; van Duyvenvoorde, Hermine A.; Boot, Annemieke M.; Kant, Sarina G.; White, Stefan J.; Losekoot, Monique; Den Dunnen, Johan T.; Karperien, Marcel; Wit, Jan M.

    2008-01-01

    Context: Microscopically visible heterozygous terminal 15q deletions encompassing the IGF1R gene are rare and usually associated with intrauterine growth retardation and short stature. The incidence of submicroscopic deletions is unknown, as is the effect of GH therapy in this condition. Objective:

  11. Successful long-term growth hormone therapy in a girl with haploinsufficiency of the insulin-like growth factor-I receptor due to a terminal 15q26.2->qter deletion detected by multiplex ligation probe amplification

    NARCIS (Netherlands)

    M.J.E. Walenkamp (Marie); S.M.P.F. de Muinck Keizer-Schrama (Sabine); M. de Mos (Marianne); M.E. Kalf (Margot); H.A. van Duyvenvoorde (Hermine); A.M. Boot (Annemieke); S.G. Kant (Sarina); S.J. White (Stefan); M. Losekoot (Monique); J.T. den Dunnen (Johan); M. Karperien (Marcel); J.M. Wit (Jan)

    2008-01-01

    textabstractContext: Microscopically visible heterozygous terminal 15q deletions encompassing the IGF1R gene are rare and usually associated with intrauterine growth retardation and short stature. The incidence of submicroscopic deletions is unknown, as is the effect of GH therapy in this condition.

  12. Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262): clinical effectiveness systematic review and economic model.

    Science.gov (United States)

    Archer, Rachel; Tappenden, Paul; Ren, Shijie; Martyn-St James, Marrissa; Harvey, Rebecca; Basarir, Hasan; Stevens, John; Carroll, Christopher; Cantrell, Anna; Lobo, Alan; Hoque, Sami

    2016-01-01

    BACKGROUND Ulcerative colitis (UC) is the most common form of inflammatory bowel disease in the UK. UC can have a considerable impact on patients' quality of life. The burden for the NHS is substantial. OBJECTIVES To evaluate the clinical effectiveness and safety of interventions, to evaluate the incremental cost-effectiveness of all interventions and comparators (including medical and surgical options), to estimate the expected net budget impact of each intervention, and to identify key research priorities. DATA SOURCES Peer-reviewed publications, European Public Assessment Reports and manufacturers' submissions. The following databases were searched from inception to December 2013 for clinical effectiveness searches and from inception to January 2014 for cost-effectiveness searches for published and unpublished research evidence: MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library including the Cochrane Systematic Reviews Database, Cochrane Controlled Trials Register, Database of Abstracts of Reviews of Effects, the Health Technology Assessment database and NHS Economic Evaluation Database; ISI Web of Science, including Science Citation Index, and the Conference Proceedings Citation Index-Science and Bioscience Information Service Previews. The US Food and Drug Administration website and the European Medicines Agency website were also searched, as were research registers, conference proceedings and key journals. REVIEW METHODS A systematic review [including network meta-analysis (NMA)] was conducted to evaluate the clinical effectiveness and safety of named interventions. The health economic analysis included a review of published economic evaluations and the development of a de novo model. RESULTS Ten randomised controlled trials were included in the systematic review. The trials suggest that adult patients receiving infliximab (IFX) [Remicade(®), Merck Sharp & Dohme Ltd (MSD)], adalimumab (ADA) (Humira(®), AbbVie) or golimumab (GOL) (Simponi(®), MSD) were more likely to achieve clinical response and remission than those receiving placebo (PBO). Hospitalisation data were limited, but suggested more favourable outcomes for ADA- and IFX-treated patients. Data on the use of surgical intervention were sparse, with a potential benefit for intervention-treated patients. Data were available from one trial to support the use of IFX in paediatric patients. Safety issues identified included serious infections, malignancies and administration site reactions. Based on the NMA, in the induction phase, all biological treatments were associated with statistically significant beneficial effects relative to PBO, with the greatest effect associated with IFX. For patients in response following induction, all treatments except ADA and GOL 100 mg at 32-52 weeks were associated with beneficial effects when compared with PBO, although these were not significant. The greatest effects at 8-32 and 32-52 weeks were associated with 100 mg of GOL and 5 mg/kg of IFX, respectively. For patients in remission following induction, all treatments except ADA at 8-32 weeks and GOL 50 mg at 32-52 weeks were associated with beneficial effects when compared with PBO, although only the effect of ADA at 32-52 weeks was significant. The greatest effects were associated with GOL (at 8-32 weeks) and ADA (at 32-52 weeks). The economic analysis suggests that colectomy is expected to dominate drug therapies, but for some patients, colectomy may not be considered acceptable. In circumstances in which only drug options are considered, IFX and GOL are expected to be ruled out because of dominance, while the incremental cost-effectiveness ratio for ADA versus conventional treatment is approximately £50,300 per QALY gained. LIMITATIONS The health economic model is subject to several limitations: uncertainty associated with extrapolating trial data over a lifetime horizon, the model does not consider explicit sequential pathways of non-biological treatments, and evidence relating to complications of colectomy was identified through consideration of approaches used within previous models rather than a full systematic review. CONCLUSIONS Adult patients receiving IFX, ADA or GOL were more likely to achieve clinical response and remission than those receiving PBO. Further data are required to conclusively demonstrate the effect of interventions on hospitalisation and surgical outcomes. The economic analysis indicates that colectomy is expected to dominate medical treatments for moderate to severe UC. STUDY REGISTRATION This study is registered as PROSPERO CRD42013006883. FUNDING The National Institute for Health Research Health Technology Assessment programme. PMID:27220829

  13. Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100

    DEFF Research Database (Denmark)

    Hatse, S; Princen, K; Gerlach, L O;

    2001-01-01

    that the antagonistic action of AMD3100 against CXCR4--as assessed by the inhibitory effects of the compound on stromal cell-derived factor (SDF-1) binding to its receptor and on SDF-1-induced intracellular calcium signaling, and by displacement of the CXCR4-specific antibody, clone 12G5--was greatly reduced...

  14. Reply to comment on "A procedure for the estimation of the numerical uncertainty of CFD calculations based on grid refinement studies" (L. Eça and M. Hoekstra, Journal of Computational Physics 262 (2014) 104-130)

    Science.gov (United States)

    Eça, L.; Hoekstra, M.

    2015-11-01

    We have to start by thanking the authors of this comment for their interest in our work. While quality assurance is being consolidated in several business areas, the importance of Verification and Validation (V&V) is still not fully appreciated in the CFD community. More attention for the topic is welcome.

  15. Comment on "A procedure for the estimation of the numerical uncertainty of CFD calculations based on grid refinement studies" (L. Eça and M. Hoekstra, Journal of Computational Physics 262 (2014) 104-130)

    Science.gov (United States)

    Xing, Tao; Stern, Frederick

    2015-11-01

    Eça and Hoekstra [1] proposed a procedure for the estimation of the numerical uncertainty of CFD calculations based on the least squares root (LSR) method. We believe that the LSR method has potential value for providing an extended Richardson-extrapolation solution verification procedure for mixed monotonic and oscillatory or only oscillatory convergent solutions (based on the usual systematic grid-triplet convergence condition R). Current Richardson-extrapolation solution verification procedures [2-7] are restricted to monotonic convergent solutions 0 block diagram, which summarizes the LSR procedure and options, including some of which we are in disagreement. Compared to the grid-triplet and three-step procedure followed by most solution verification methods (convergence condition followed by error and uncertainty estimates), the LSR method follows a four-grid (minimum) and four-step procedure (error estimate, data range parameter Δϕ, FS, and uncertainty estimate).

  16. Dicty_cDB: Contig-U15656-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ent EP1471146. 262 e-134 2 ( BD268208 ) Adenovirus vector, packaging cell line, compositi... 262 e-134 2 ( B...e-134 2 ( CQ947247 ) Sequence 48 from Patent WO2004099422. 262 e-134 2 ( BD268238 ) Adenovirus vector, packaging...211 ) Adenovirus vector, packaging cell line, compositi... 262 e-134 2 ( BD021943 ) Packaging cell systems f

  17. 40 CFR 266.80 - Applicability and requirements.

    Science.gov (United States)

    2010-07-01

    ... § 262.11, and either must comply with 40 CFR part 262, subpart H (if shipping to one of the OECD... requirements in 40 CFR part 262, subpart H (if shipping to one of the OECD countries specified in 40 CFR 262.58... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Applicability and requirements....

  18. Systematic study of Bh isotopes in a relativistic mean field formalism

    International Nuclear Information System (INIS)

    The binding energy, charge radius, and quadrupole deformation parameter for the isotopic chain of the superheavy element bohrium (107Bh), from proton to neutron drip line, are calculated by using an axially deformed relativistic mean field model. The potential energy surfaces for some of the selected nuclei are plotted and the various possible shapes are investigated. The rms radii, density distributions, and two-neutron separation energies are also evaluated and the single-particle energies for some illustrative cases are analyzed to see the magic structures. Furthermore, the α-decay rates are calculated and compared with the available experimental data for the recently observed new isotopes 266,267Bh

  19. Interesses e colaboração do Brasil e dos Estados Unidos com a ditadura de Stroessner (1954-63 - doi: 10.4025/dialogos.v11i1e2.62 Vested interests and collaboration between Brazil and the united states during the dictatorship of Stroessner (1954-63 - doi: 10.4025/dialogos.v11i1e2.62 Intereses y colaboración de Brasil y de EEUU con la dictadura de Stroessner (1954-1963

    Directory of Open Access Journals (Sweden)

    Ceres Moraes

    2010-05-01

    Full Text Available Neste artigo são abordados os interesses e a colaboração norte-americana e brasileira com a ditadura de Stroessner instalada no Paraguai a partir de meados de 1954. Esse regime, que durante cerca de 35 anos submeteu aquele país, foi um dos mais longos e violentos períodos de repressão do Mundo Ocidental contemporâneo. Sob a justificativa de combate ao avanço das idéias comunistas na América do Sul, os Estados Unidos colaboraram para a consolidação e permanência do regime através de ajuda econômica e da assistência técnica e militar, principalmente com a formação e treinamento de militares. O Brasil, que ainda disputava com a Argentina a supremacia regional, apesar de não mais manter a política de alinhamento incondicional com os Estados Unidos, buscava consolidar-se como parceiro preferencial e principal beneficiário de sua política na América do Sul. Na defesa de seus interesses, colaborou com o regime ditatorial de Stroessner tanto no campo econômico como no diplomático, cultural e militar. Ao contribuírem, especialmente, com assistência técnica e ajuda econômica, os Estados Unidos e o Brasil, este último de forma mais efetiva, colaboraram para a consolidação e longa permanência de Stroessner no poder.In this article are treated the interests and North American and Brazilian collaboration with the Stroessner’s dictatorship installed in Paraguay starting from1954. This regime which during about 35 years submitted that country was one of longest and violent periods of repression of the contemporary western world. Under the justification of combat to the progress of communist ideas in the South American, The United States collaborated for the consolidation and permanence of the regime through of economic help, technical assistance and military support, mainly with the formation and training of military, tend many of them studied in School of the Americas, in Panamá. The Brazil that still in this period fought with Argentina for the regional supremacy, in spite of no more to keep the political of alignment unconditional with the United States, looked for to consolidation as preferential partner and mainly beneficiary of itself politics in South America, in defense of their interests contributed with Stroessner so much in the economical field, diplomat, cultural and military. For to contribute, especially, with technical support and economic help the United States and the Brazil in a more efficient way, collaborated for the consolidation and the long permanence of Stroessner in the power.En este artículo son estudiados los intereses y la colaboración de EEUU y de Brasil con la dictadura de Stroessner instalada en Paraguay a partir de mediados de 1954. Este régimen, que sometió a Paraguay durante casi 35 años, fue uno de los más largos y violentos períodos de represión del mundo occidental contemporáneo. Con la justificativa de combatir el avance del comunismo en América del Sur, EEUU colaboró con la consolidación y la permanencia del régimen mediante ayuda económica y asistencia técnico-militar, principalmente a través de la formación y entrenamiento de militares. Brasil, que aún disputaba con Argentina la supremacía regional y a pesar de no mantener más una política de alineamiento incondicional con EEUU, buscaba consolidarse como principal referente y beneficiario de su política con América del Sur. En defensa de sus intereses, colaboró con el régimen dictatorial de Stroessner tnato en lo económico como en lo diplomático, cultural y militar. EEUU y Brasil, al contribuir con asistencia técnica y ayuda económica, colaboraron con la consolidación y la larga permanencia de Stroessner en el poder.

  20. Paul Scherrer Institute Scientific Report 1999. Volume I: Particles and Matter

    International Nuclear Information System (INIS)

    Although originally planned for fundamental research in nuclear physics, the particle beams of pions, muons, protons and neutrons are now used in a large variety of disciplines in both natural science and medicine. The beams at PSI have the world's highest intensities and therefore allow certain experiments to be performed, which would not be possible elsewhere. The highlight of research this year was the first-ever determination of the chemical properties of the superheavy element 107 Bohrium. This was undertaken, by an international team led by H. Gaeggeler of PSI's Laboratory for Radiochemistry. Bohrium was produced by bombarding a Berkelium target with Neon ions from the Injector I cyclotron and six atoms were detected after having passed through an online gas chromatography device. At the Laboratory for Particle Physics the focus has shifted from nuclear physics to elementary particle physics with about a fifty-fifty split between investigations of rare processes or particle decays using the high intensity muon, pion and recently also polarized neutron beams of PSI, and research at the highest energy frontier at CERN (Geneva) and DESY (Hamburg). Important space instrumentation has been contributed by the Laboratory for Astrophysics to the European Space Agency and NASA satellite programmes. The Laboratory for Micro and Nanotechnology continued to focus on research into molecular nanotechnology and SiGeC nanostructures, the latter with the aim of producing silicon based optoelectronics. Progress in 1999 in these topical areas is described in this report. A list of scientific publications in 1999 is also provided

  1. アントラサイクリン抗生物質生産菌Streptomyces violaceus A262及びStreptomyces sp.D788より生合成ブロック変異株の単離と異種間プロトプラスト融合の試み

    OpenAIRE

    Ktsuta, Yoshiaki; SAITO, Shinji; Oyabu, Takeshi; Yoshimoto, Akihiro

    1995-01-01

    ロドマイシン群抗生物質生産菌 Streptomyces violaceus 及びダウノマイシン生産菌Streptomyces sp. D788 の変異処理により、新規生合成中間体を蓄積する生合成ブロック変異株12種を単離した。生成物の薄層クロマグラフィーの結果から、7株は生合成初期段階がブロックされ前駆体アグリコン類を蓄積する変異株、5株はグリコシル化以降の段階でブロックされグリコシド中間体を蓄積する変異株であった。また、両菌種間で生合成ブロック変異の組換えをおこなう目的でプロトプラスト融合による異種間遺伝子組換えを試みたが起こらなかった。...

  2. A High Performance Backend for Array-Oriented Programming on Next-Generation Processing Units

    DEFF Research Database (Denmark)

    Lund, Simon Andreas Frimann

    are analyzed and experimentally tested. Resulting in the design and implementation of Bohrium a runtime-system for transforming, scheduling and executing array-oriented programs. Multiple interfaces for existing languages such as Python, C++, C#, and F# have been built which utilize the backend. A suite......The financial crisis, which started in 2008, spawned the HIPERFIT research center as a preventive measure against future financial crises. The goal of prevention is to be met by improving mathematical models for finance, the verifiable description of them in domain-specific languages...... of benchmarks applications, implemented in these languages, demonstrate the high-level declarative form of the programming model. Performance studies show that the high-level declarative programming model can be used to not only match but also exceed the performance of hand-coded implementations in low...

  3. Paul Scherrer Institute Scientific Report 1999. Volume I: Particles and Matter

    Energy Technology Data Exchange (ETDEWEB)

    Gobrecht, J.; Gaeggeler, H.; Herlach, D.; Junker, K.; Kettle, P.-R.; Kubik, P.; Zehnder, A. [eds.

    2000-07-01

    lthough originally planned for fundamental research in nuclear physics, the particle beams of pions, muons, protons and neutrons are now used in a large variety of disciplines in both natural science and medicine. The beams at PSI have the world's highest intensities and therefore allow certain experiments to be performed, which would not be possible elsewhere. The highlight of research this year was the first-ever determination of the chemical properties of the superheavy element {sup 107} Bohrium. This was undertaken, by an international team led by H. Gaeggeler of PSI's Laboratory for Radiochemistry. Bohrium was produced by bombarding a Berkelium target with Neon ions from the Injector I cyclotron and six atoms were detected after having passed through an online gas chromatography device. At the Laboratory for Particle Physics the focus has shifted from nuclear physics to elementary particle physics with about a fifty-fifty split between investigations of rare processes or particle decays using the high intensity muon, pion and recently also polarized neutron beams of PSI, and research at the highest energy frontier at CERN (Geneva) and DESY (Hamburg). Important space instrumentation has been contributed by the Laboratory for Astrophysics to the European Space Agency and NASA satellite programmes. The Laboratory for Micro and Nanotechnology continued to focus on research into molecular nanotechnology and SiGeC nanostructures, the latter with the aim of producing silicon based optoelectronics. Progress in 1999 in these topical areas is described in this report. A list of scientific publications in 1999 is also provided.

  4. 40 CFR 273.56 - Exports.

    Science.gov (United States)

    2010-07-01

    ... countries specified in 40 CFR 262.58(a)(1) (in which case the transporter is subject to the requirements of 40 CFR part 262, subpart H) may not accept a shipment if the transporter knows the shipment does not... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.56 Section...

  5. Distribution, abundance and ecology of the meiofauna in a tropical estuary along the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ansari, Z.A; Parulekar, A

    stream_size 12 stream_content_type text/plain stream_name Hydrobiologia_262_115.pdf.txt stream_source_info Hydrobiologia_262_115.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  6. 40 CFR 273.3 - Applicability-pesticides.

    Science.gov (United States)

    2010-07-01

    ... collection program. (b) Pesticides not covered under 40 CFR part 273. The requirements of this part do not... are managed by farmers in compliance with 40 CFR 262.70. (40 CFR 262.70 addresses pesticides disposed... label, providing the container is triple rinsed in accordance with 40 CFR 261.7(b)(3)); (2)...

  7. Migrating Art History

    DEFF Research Database (Denmark)

    Ørum, Tania

    2012-01-01

    Review of Hiroko Ikegami, The Great Migrator. Robert Rauschenberg and the Global Rise of American Art. Cambridge Mass., The MIT Press, 2010. 277 pages. ISBN 978-0-262-01425-0.......Review of Hiroko Ikegami, The Great Migrator. Robert Rauschenberg and the Global Rise of American Art. Cambridge Mass., The MIT Press, 2010. 277 pages. ISBN 978-0-262-01425-0....

  8. AcEST: DK954856 [AcEST

    Lifescience Database Archive (English)

    Full Text Available = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDVKCQGCFSITTVFSHSQTVVLCGN 262 MVL NDIDLL+PPAE+EK+KHKLKRLVQSPNS+FMDV...KCQGCF+ITTVFSHSQTVV+CGN Sbjct: 1 MVLQNDIDLLNPPAELEKRKHKLKRLVQSPNSFFMDVKCQGCFNITTVFSHSQTVVVCGN 60 Q...(92%) Frame = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDVKCQGCFSITTVFSHSQTVVLCGN 262 MVL NDIDLLHPP E+EK+KHKLKRLVQSPNS+FMDV...KCQGCF+ITTVFSHSQTVV+CGN Sbjct: 1 MVLQNDIDLLHPPPELEKRKHKLKRLVQSPNSFFMDV... 70/84 (83%), Positives = 79/84 (94%) Frame = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDVKCQGCFSITTVF

  9. Analysis of the Relationship between Antioxidant Enzyme Gene Polymorphisms and Their Activity in Post-Traumatic Gonarthrosis.

    Science.gov (United States)

    Vnukov, V V; Panina, S B; Milyutina, N P; Krolevets, I V; Zabrodin, M A

    2016-05-01

    Analysis of polymorphisms of genes encoding antioxidant enzymes SOD1 (G7958A), SOD2 (T58C), CAT (C-262T), and GSTP1 (Ile105Val) in 93 patients with post-traumatic gonarthrosis showed that GSTP1 Ile105Val polymorphism is often associated with heterozygous mutation in catalase gene CAT C-262T. In gonarthrosis, catalase activity in peripheral blood mononuclear cells in patients with CT genotype of the C-262T locus of CAT gene more than 2-fold surpassed that in CC genotype and more than 50% surpassed the normal. Changes in the balance of activity of antioxidant enzymes can affect viability of mononuclear cells. PMID:27270931

  10. Pettused passidega sunnivad uusi nõudeid kehtestama / Anneli Härmson

    Index Scriptorium Estoniae

    Härmson, Anneli

    2015-01-01

    17. veebruaril vastuvõetud ja 1. jaanuarist 2016 kehtuma hakkavast Euroopa Komisjoni rakendusmäärusest 2015/262/EMÜ, milles sätestatakse hobuslaste identifitseerimise meetodeid käsitlevad eeskirjad

  11. 38 CFR 3.261 - Character of income; exclusions and estates.

    Science.gov (United States)

    2010-07-01

    ... ......do ......do ......do § 3.262(q)(2). (34) The Service Corps of Retired Executives (SCORE) and Active... drug discount card and transitional assistance program (42 U.S.C. 1395w-141(g)(6)) Excluded...

  12. Earth System Governance: Facing the Challenges of Climate Change

    Directory of Open Access Journals (Sweden)

    Susana Camargo Vieira

    2013-01-01

    Full Text Available YOUNG, Oran R. Institutional Dynamics: Emergent Patterns in International Environmental Governance. Cambridge (Massachusets, USA: The MIT Press, 2010. Earth System Governance Series. 225p. (Paperback; alkaline paper. ISBN 978-0-262-51440-8.

  13. Mutations in ANTXR1 Cause GAPO Syndrome

    NARCIS (Netherlands)

    Stranecky, V.; Hoischen, A.; Hartmannova, H.; Zaki, M.S.; Chaudhary, A.; Zudaire, E.; Noskova, L.; Baresova, V.; Pristoupilova, A.; Hodanova, K.; Sovova, J.; Hulkova, H.; Piherova, L.; Hehir-Kwa, J.Y.; Silva, D. De; Senanayake, M.P.; Farrag, S.; Zeman, J.; Martasek, P.; Baxova, A.; Afifi, H.H.; Croix, B. St.; Brunner, H.G.; Temtamy, S.; Kmoch, S.

    2013-01-01

    The genetic cause of GAPO syndrome, a condition characterized by growth retardation, alopecia, pseudoanodontia, and progressive visual impairment, has not previously been identified. We studied four ethnically unrelated affected individuals and identified homozygous nonsense mutations (c.262C>T [

  14. Metrology: Schrödinger's cat beats a quantum limit

    Science.gov (United States)

    Adams, Charles S.

    2016-07-01

    Quantum effects have been used in devices that measure various quantities, but not to measure electric fields. The sensitivity of an electrometer has now been boosted using the phenomenon of quantum superposition. See Letter p.262

  15. Kuidas kirjutatakse ajalugu? / Carlo Ginzburg ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Ginzburg, Carlo

    2007-01-01

    Ülevaade Pisa Euroopa kultuuride professori C. Ginzburg'i teostest. Varem. ilm.: Märgid, jäljed ja tõendid : intervjuu Carlo Ginzburgiga // Ginzburg, Carlo. Juust ja vaglad. - Tallinn, 2000. - Lk. 262-271

  16. Microstructural evolution and response to double-loop reactivation testing of heat-treated PH 13-8 Mo martensitic stainless steel

    International Nuclear Information System (INIS)

    Compared to the austenitic stainless steels, relatively few studies have been reported of the intergranular corrosion suceptibility of martensitic stainless steels, particularly those containing 0.05 corresponds to a ditch structure in ASTM A 262-A (oxalic acid)

  17. ERRATUM Nonlinear aspects of energy dissipation in wood-panel joints

    Institute of Scientific and Technical Information of China (English)

    Sara Casciati

    2007-01-01

    @@ We have found some mistakes in the article by Sara Casciati(2007).The revisions are given below: 1.The last sentence of the first paragraph in p.262 "(Casciati and Faravelli,2007)" should be changed to "(Casciati and Faravelli,1991)".

  18. Genetics Home Reference: Naegeli-Franceschetti-Jadassohn syndrome/dermatopathia pigmentosa reticularis

    Science.gov (United States)

    ... family demonstrating autosomal dominant inheritance. J Am Acad Dermatol. 1992 Feb;26(2 Pt 2):298-301. ... delineation of its clinical manifestations. J Am Acad Dermatol. 1993 Jun;28(6):942-50. Citation on ...

  19. Muscular Dystrophy

    Science.gov (United States)

    ... 1 (DM1) . The International Myotonic Dystrophy Consortium (IDMC). Neurology. Mar 28 2000;54(6):1218-1221. 5. ... Udd B. Distal muscular dystrophies. Handbook of clinical neurology. 2011;101:239-262. 4. Nonaka I. Distal ...

  20. Dicty_cDB: Contig-U04672-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available aaaaaatatttttataatatcttttcatatagttttact 261 Query: 262 tatagcgtcattattaagggcggtatcattttcacttttnnnaanaaanganga...62 tatagcgtcattattaagggcggtatcattttcacttttnnnaanaaangangaaaangt 321 Query: 322 taaagaaactngatggtaatcnattgntt...(5) = 0.0 Identities = 157/180 (87%) Strand = Plus / Plus Query: 307 aaangangaaaangttaaagaaactngatggtaatcnat

  1. UOK 268 Cell Line for Hereditary Leiomyomatosis and Renal Cell Carcinoma | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute’s Urologic Oncology Branch seeks parties to co-develop the UOK 262 immortalized cell line as research tool to study aggressive hereditary leiomyomatosis and renal cell carcinoma (HLRCC)-associated recurring kidney cancer.

  2. EST Table: FY019190 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY019190 rbmov24h07 11/11/04 53 %/262 aa ref|XP_002092422.1| GE14184 [Drosophila ya...kuba] gb|EDW92134.1| GE14184 [Drosophila yakuba] 11/11/04 53 %/262 aa FBpp0259194|DyakGE14184-PA 11/11/04 32...1 11/11/04 51 %/245 aa AGAP003676-PA Protein|2R:41815789:41819862:-1|gene:AGAP003

  3. H.264及相关视频编码标准论述%H.264 and Relevant Video Coding Standards

    Institute of Scientific and Technical Information of China (English)

    吴峰; 张珂; 高远航

    2006-01-01

    @@ 1 H.264的产生 视频压缩国际标准主要有:由ITU-T制定的H.261、H.262、H.263、H.264和由MPEG制定的MPEG-1、MPEG-2、MPEG-4,其中H.262/MPEG-2和H.264/MPEG-4 AVC由ITU-T与MPEG联合制定.

  4. AcEST: DK961254 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 82/86 (95%) Frame = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDVKCQGCFSITTVFSHSQTVVLCGN 262 MVL NDIDLL...+PPAE+EK+KHKLKRLVQSPNS+FMDVKCQGCF+ITTVFSHSQTVV+CGN Sbjct: 1 MVLQNDIDLLNPPAELEKRKHKLKRLVQSPNSFFMDVKCQGCFNITTV...ositives = 78/84 (92%) Frame = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDVKCQGCFSITTVFSHSQTVVLCGN 262... MVL NDIDLLHPP E+EK+KHKLKRLVQSPNS+FMDVKCQGCF+ITTVFSHSQTVV+CGN Sbjct: 1 MVLQNDIDLL...e-37 Identities = 70/84 (83%), Positives = 79/84 (94%) Frame = +2 Query: 83 MVLSNDIDLLHPPAEVEKKKHKLKRLVQSPNSYFMDV

  5. EST Table: AU002723 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AU002723 n0388 10/09/28 98 %/262 aa pdb|2I1J|A Chain A, Moesin From Spodoptera Frugiperda At 2.1 Angstrom...s Resolution pdb|2I1K|A Chain A, Moesin From Spodoptera Frugiperda Reveals The Coiled-Coil Domain At 3.0 Angstr...om Resolution gb|ABK60307.1| moesin [Spodoptera frugiperda] 10/08/28 88 %/262 aa FB

  6. Single and double acceptor-levels of a carbon-hydrogen defect in n-type silicon

    Science.gov (United States)

    Stübner, R.; Scheffler, L.; Kolkovsky, Vl.; Weber, J.

    2016-05-01

    In the present study, we discuss the origin of two dominant deep levels (E42 and E262) observed in n-type Si, which is subjected to hydrogenation by wet chemical etching or a dc H-plasma treatment. Their activation enthalpies determined from Laplace deep level transient spectroscopy measurements are EC-0.06 eV (E42) and EC-0.51 eV (E262). The similar annealing behavior and identical depth profiles of E42 and E262 correlate them with two different charge states of the same defect. E262 is attributed to a single acceptor state due to the absence of the Poole-Frenkel effect and the lack of a capture barrier for electrons. The emission rate of E42 shows a characteristic enhancement with the electric field, which is consistent with the assignment to a double acceptor state. In samples with different carbon and hydrogen content, the depth profiles of E262 can be explained by a defect with one H-atom and one C-atom. From a comparison with earlier calculations [Andersen et al., Phys. Rev. B 66, 235205 (2002)], we attribute E42 to the double acceptor and E262 to the single acceptor state of the CH1AB configuration, where one H atom is directly bound to carbon in the anti-bonding position.

  7. Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.

    Science.gov (United States)

    Ando, Kanae; Oka, Mikiko; Ohtake, Yosuke; Hayashishita, Motoki; Shimizu, Sawako; Hisanaga, Shin-Ichi; Iijima, Koichi M

    2016-09-16

    Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer's disease (AD). AD-related phosphorylation of two tau residues, Ser262 and Ser356, by PAR-1/MARK stabilizes tau in the initial phase of mismetabolism, leading to subsequent phosphorylation events, accumulation, and toxicity. However, the relative contribution of phosphorylation at each of these sites to tau stabilization has not yet been elucidated. In a Drosophila model of human tau toxicity, we found that tau was phosphorylated at Ser262, but not at Ser356, and that blocking Ser262 phosphorylation decreased total tau levels. By contrast, when PAR-1 was co-overexpressed with tau, tau was hyperphosphorylated at both Ser262 and Ser356. Under these conditions, the protein levels of tau were significantly elevated, and prevention of tau phosphorylation at both residues was necessary to completely suppress this elevation. These results suggest that tau phosphorylation at Ser262 plays the predominant role in tau stabilization when PAR-1/MARK activity is normal, whereas Ser356 phosphorylation begins to contribute to this process when PAR-1/MARK activity is abnormally elevated, as in diseased brains. PMID:27520376

  8. AcEST: BP912016 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000012_A10 262 Adiantum capillus-veneris mRNA. clone: YMU001_000012_A10. BP912016 - Show BP912016...is mRNA. clone: YMU001_000012_A10. Accession BP912016 Tissue type prothallium Developmental stage - Contig I...ase search programs, Nucleic Acids Res. 25:3389-3402. Query= BP912016|Adiantum capillus-veneris mRNA, clone:.... 25:3389-3402. Query= BP912016|Adiantum capillus-veneris mRNA, clone: YMU001_000012_A10. (262 letters) Data

  9. Drug: D07256 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D07256 Drug Etoglucid (INN) C12H22O6 262.1416 262.2995 D07256.gif Same as: C19537 A...NOMODULATING AGENTS L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AG Epoxides L01AG01 Etoglucid D07256 Etoglucid... (INN) Antineoplastics [BR:br08308] Alkylating agents Epoxides Etoglucid... [ATC:L01AG01] D07256 Etoglucid (INN) CAS: 1954-28-5 PubChem: 51091594 LigandBox: D07256 NIKKAJI: J54.369A

  10. EST Table: FY039396 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY039396 rbmte20m01 11/11/04 47 %/262 aa ref|XP_974065.1| PREDICTED: similar to Outer dense fiber... protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber protein) (Ce...er protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber protein) (Cenexin) [Tribolium castaneum] FS893448 bmte ... ...nl|Amel|GB14311-PA 11/11/04 47 %/262 aa gi|91078946|ref|XP_974065.1| PREDICTED: similar to Outer dense fib

  11. International measures project for rational energy use (Survey project of the analysis tool of Asian energy consumption efficiency). List of errata; 1998 nendo kokusai energy shiyo gorika nado taisaku jigyo seigohyo. Asia energy shohi koritsuka bunseki tool chosa jigyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The list of errata was prepared for the data book of the international measures project for rational energy use (Survey project of the analysis tool of Asian energy consumption efficiency). Corrected pages of the data book 1 (1990) are as follows: 187-190, 223-226, 259-262, 295- 298, 369-370, 387-388 and 405-406 on Malaysian data. Corrected pages of the data book 2 (1985) are as follows: 102-105 on Chinese data, 154 on common data, and 187-190, 223-226, 259-262, 295-298, 369-370, 387-388 and 405-406 on Malaysian data. (NEDO)

  12. GETDB: 112348 [GETDB

    Lifescience Database Archive (English)

    Full Text Available 112348 Link to Original w[*] P{GawB}NP0820 / FM7c 9D3 Link to DGRC Genome Viewer: 11234...e of Genetics. FM7c Link to clone table - 1 262 Link to cluster table 262 1 Request - AS, cns - sg, cns - - - - - - - - Show 11234...8 DGRC Number 112348 Link to Original Genotype w[*] P{GawB}...NP0820 / FM7c Insertion Site 9D3 Map Viewer Link to DGRC Genome Viewer: 112348 Related Genes spri H-element{

  13. Properties of Group Five and Group Seven transactinium elements

    Energy Technology Data Exchange (ETDEWEB)

    Wilk, Philip A.

    2001-05-01

    The detection and positive identification of the short-lived, low cross section isotopes used in the chemical studies of the heaviest elements are usually accomplished by measuring their alpha-decay, thus the nuclear properties of the heaviest elements must be examined simultaneously with their chemical properties. The isotopes 224 Pa and 266,267 Bh have been studied extensively as an integral part of the investigation of the heaviest members of the groups five and seven of the periodic table. The half-life of 224 Pa was determined to be 855 plus/minus19 ms by measuring its alpha-decay using our rotating wheel, solid state detector system at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron. Protactinium was produced by bombardment of a bismuth target. New neutron rich isotopes, 267 Bh and 266 Bh, were produced in bombardments of a 249 Bk target and their decay was observed using the rotating wheel system. The 266 Bh that was produced decays with a half-life of approximately 1 s by emission of alpha particles with an average energy of 9.25 plus/minus 0.03 MeV. 267 Bh was observed to decay with a 17 s half-life by emission of alpha-particles with an average energy of 8.83 plus/minus 0.03 MeV. The chemical behavior of hafnium, Ha (element 105) was investigated using the fast on-line continuous liquid extraction and detection system SISAK-LISSY. Hafnium was not observed in this experiment following transport and extraction. Protactinium was used as on-line test of the apparatus to determine the experimental efficiency of the entire system. Unfortunately, the amount of protactinium observed after the extraction, compared to the amount produced, was extremely small, only 2.5%. The extraction of the protactinium isotope indicated the efficiency of the apparatus was too low to observe the extraction of hafnium. The chemical behavior of oxychloride compounds of bohrium was investigated by isothermal gas adsorption chromatography in a quartz column at 180, 150

  14. An experimental paradigm opening the world of superheavy elements

    Science.gov (United States)

    Armbruster, P.; Münzenberg, Gottfried

    2012-07-01

    The history of the discovery of the six elements Z = 107 ∓ 112, bohrium, hassium, meitnerium, darmstadtium, roentgenium, and copernicium goes back to the early 1960s. An experimental method to separate and identify rare nuclear reaction products, the recoil separation, was developed and optimised for beams of fission products at European research reactors. Chemical elements beyond the then first transactinides ( Z = 104), which owe their stability to the internal structure of atomic nuclei, were predicted theoretically. A big brother of the shell-stabilised nucleus 208Pb, a spherical magic nucleus at Z = 114∓126 and N = 184, might reach lifetimes long enough to be detected. In the seventies, hunting superheavy elements (SHE) was on the agenda of nuclear chemistry. Could the Periodic Table of Elements be extended to Z = 120, and is the order of electrons in the atom still following the laws established for lighter elements? In Germany, the heavy ion accelerator (UNILAC) was built by Christoph Schmelzer and his team at GSI, Darmstadt. SHE and UNILAC met the recoil separators in 1968, and SHIP (Separator for Heavy Ion reaction Products) was ready together with the first UNILAC-beams in 1976. Recoil separation is orders of magnitude more sensitive, selective, and faster than earlier methods used to synthesise elements up to seaborgium, Z = 106. The experimental paradigm we introduced opened the world of SHEs. At SHIP we discovered and investigated the elements Z = 107∓112 in the years 1980-2000. Our laboratory was the world champion during this time. Today our experimental method is used worldwide in the search for SHEs, but the leadership went to the Russian laboratory JINR in Dubna, which extended the Periodic Table by 6 more elements to Z = 118, the candidate for the next rare gas.

  15. Synthesis of the heaviest nuclei in cold fusion reactions

    Science.gov (United States)

    Münzenberg, G.; Morita, K.

    2015-12-01

    Cold fusion of heavy ions paved the way to superheavy elements. It was proposed by Yu.Ts. Oganessian more than forty years ago in 1974 [1,2]. First experiments were carried out at JINR Dubna, starting with the reaction 40Ar + 208Pb → 248Fm* where several hundreds to thousand atoms were produced on one day. The large production rate indicating an enhancement of the fusion cross section, especially for the evaporation of two or three neutrons, proved the concept of cold-fusion with the use of the doubly magic nucleus 208Pb as a target. The Dubna experiments were extended to the transactinide region beyond rutherfordium. The breakthrough came with the separation in-flight. Two different approaches were used: kinematic separation with the velocity filter SHIP [3] at GSI Darmstadt, and with the gasfilled separator GARIS [4,5] at RIKEN. With SHIP the concept of cold fusion of massive nuclear systems was convincingly confirmed by the observation of the one-neutron evaporation channel in the production of 247Rf in an irradiation of 208Pb with 50Ti [6] in 1981 which opened the way to the transactinide region. At SHIP the elements bohrium (107) to copernicium (112) were discovered [7]. A new closed shell region around hassium was found. The RIKEN experiments started in 2002. They confirmed the GSI results and in addition improved the data on structure and production of elements hassium to copernicium significantly. The heaviest element ever created in a cold fusion reaction, Z = 113, was observed at GARIS [8,9].

  16. Data of evolutionary structure change: 1E4XI-1CF8H [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E4XI-1CF8H 1E4X 1CF8 I H QVQLQQPGAELVKPGPSVKLSCKASGFTFT-NYWMHWVK...EEE EEEEEEEEEE EEEEEEE EEEEEE - 0 1E4X... I 1E4XI...A 262 ASP CA 228 THR CA 300 ARG CA 287 1E4X... I 1E4XI

  17. Classroom Writing Environments and Children's Early Writing Skills: An Observational Study in Head Start Classrooms

    Science.gov (United States)

    Zhang, Chenyi; Hur, Jinhee; Diamond, Karen E.; Powell, Douglas

    2015-01-01

    This study examined the classroom writing environment in 31 Head Start classrooms, and explored the relations between the writing environment, children's (N = 262) name-writing, and children's letter knowledge using pathway analysis. Our analyses showed that Head Start classrooms provided opportunities (i.e., writing materials and teachers'…

  18. An Old Problem with New Directions: Maori Language Revitalisation and the Policy Ideas of Youth

    Science.gov (United States)

    Albury, Nathan John

    2016-01-01

    Legislative changes are afoot in New Zealand that are formalising an ideological shift in policy that decreasingly positions the Maori language a matter of interethnic national identity but increasingly as one for Maori self-determination. The Waitangi Tribunal (WAI262, Waitangi Tribunal, 2011) established that, from here on, Maori language policy…

  19. Data of evolutionary structure change: 1JE6A-2HJKA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1JE6A-2HJKA 1JE6 2HJK A A MEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDR...CA 188 ARG CA 262 ARG CA 318 ALA CA 382 2HJK... A 2HJKA VRFDSDAA...line>LEU CA 215 2HJK A 2HJK... 388 LEU CA 398 GLN CA 301 2HJK

  20. Phonological Skills and Vocabulary Knowledge Mediate Socioeconomic Status Effects in Predicting Reading Outcomes for Chinese Children

    Science.gov (United States)

    Zhang, Yuping; Tardif, Twila; Shu, Hua; Li, Hong; Liu, Hongyun; McBride-Chang, Catherine; Liang, Weilan; Zhang, Zhixiang

    2013-01-01

    This study examined the relations among socioeconomic status (SES), early phonological processing, vocabulary, and reading in 262 children from diverse SES backgrounds followed from ages 4 to 9 in Beijing, China. SES contributed to variations in phonological skills and vocabulary in children's early development. Nonetheless, early phonological and…

  1. 76 FR 47578 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2011-08-05

    ... Register. EIS No. 20110245, Draft EIS, BLM, NV, Sloan Hills Competitive Mineral Material Sales Project... 605-343-1567. Amended Notices EIS No. 20110179, Draft EIS, USFS, CO, Ski Resort Peak 6 Project, To..., Summit County, CO, Comment Period Ends: 08/26/2011, Contact: Jan Cutts 970-262-3451. Revision to...

  2. Some New Inverse-type Hilbert-Pachpatte Integral Inequalities

    Institute of Scientific and Technical Information of China (English)

    Young Ho KIM

    2004-01-01

    In this paper, some new generalizations of inverse type Hilbert-Pachpatte integral inequalities are proved. The results of this paper reduce to those of Pachpatte (1998, J. Math. Anal. Appl.226, 166-179) and Zhao and Debnath (2001, J. Math. Anal. Appl. 262, 411-418).

  3. 39 CFR 261.2 - Authority.

    Science.gov (United States)

    2010-07-01

    .... Included is the authority to issue records management policy and to delegate or take appropriate action if... UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RECORDS AND INFORMATION MANAGEMENT § 261.2... dispose of such property. (b) 39 CFR 262.2 assigns to the Postal Service Records Office, located under...

  4. Gravimetric Analysis of Bismuth in Bismuth Subsalicylate Tablets: A Versatile Quantitative Experiment for Undergraduate Laboratories

    Science.gov (United States)

    Davis, Eric; Cheung, Ken; Pauls, Steve; Dick, Jonathan; Roth, Elijah; Zalewski, Nicole; Veldhuizen, Christopher; Coeler, Joel

    2015-01-01

    In this laboratory experiment, lower- and upper-division students dissolved bismuth subsalicylate tablets in acid and precipitated the resultant Bi[superscript 3+] in solution with sodium phosphate for a gravimetric determination of bismuth subsalicylate in the tablets. With a labeled concentration of 262 mg/tablet, the combined data from three…

  5. 40 CFR 63.4551 - How do I demonstrate initial compliance with the emission limitations?

    Science.gov (United States)

    2010-07-01

    ... initial compliance demonstration for each general use, TPO, automotive lamp, and assembled on-road vehicle... Products” (incorporated by reference, see § 63.14), information from the supplier or manufacturer of the... facility that is regulated as a TSDF under 40 CFR part 262, 264, 265, or 266. The TSDF may be either...

  6. Friendship Conflict, Conflict Responses, and Instability: Unique Links to Anxious and Angry Forms of Rejection Sensitivity

    Science.gov (United States)

    Croft, Carissa D.; Zimmer-Gembeck, Melanie J.

    2014-01-01

    Rejection sensitivity (RS) instigates conflict and prompts maladaptive conflict responses within romantic relationships. We tested whether RS had similar effects within friendships (N = 262, X[subscript age] = 11.7) by investigating whether (a) RS was associated with more frequent conflict, (b) two RS forms prompted different conflict responses,…

  7. Depression in Low-Income Elementary School Children in South Korea: Gender Differences

    Science.gov (United States)

    Lee, Gyungjoo; McCreary, Linda; Kim, Mi Ja; Park, Chang Gi; Jun, Won Hee; Yang, Soo

    2013-01-01

    This study examined depression in low-income elementary school children and identified gender differences in factors that influence depression from an ecological perspective. Participants were 262 first- to sixth-grade children recruited from six Korean community centers. Personal factors were anxiety and self-concept. Environmental factors…

  8. 20 CFR 627.405 - Grant agreement and funding.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Grant agreement and funding. 627.405 Section... agreement and funding. (a)(1) Pursuant to § 627.200 of this part and the Governor/Secretary agreement, each...) Funding. The Secretary shall allot funds to the States in accordance with sections 162, 202, 252, 262,...

  9. Heart failure

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009170 Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure. TANG Yanhong(唐艳红),et al.Dept Cardiol,Renmin Hosp,Wuhan Univ,Wuhan 430060.Chin J Cardiol,2009;37(3):262-267.

  10. 40 CFR 273.33 - Waste management.

    Science.gov (United States)

    2010-07-01

    ... CFR part 261, subpart C. (i) If the electrolyte and/or other solid waste exhibit a characteristic of hazardous waste, it must be managed in compliance with all applicable requirements of 40 CFR parts 260... is subject to 40 CFR part 262. (ii) If the electrolyte or other solid waste is not hazardous,...

  11. 40 CFR 273.52 - Waste management.

    Science.gov (United States)

    2010-07-01

    ... Transportation regulations in 49 CFR part 171 through 180 for transport of any universal waste that meets the definition of hazardous material in 49 CFR 171.8. For purposes of the Department of Transportation... Requirements of the U.S. Environmental Protection Agency specified in 40 CFR part 262. Because universal...

  12. Chronological Age, Cognitions, and Practices in European American Mothers: A Multivariate Study of Parenting

    Science.gov (United States)

    Bornstein, Marc H.; Putnick, Diane L.

    2007-01-01

    The authors studied multiple parenting cognitions and practices in European American mothers (N=262) who ranged from 15 to 47 years of age. All were 1st-time parents of 20-month-old children. Some age effects were 0; others were linear or nonlinear. Nonlinear age effects determined by spline regression showed significant associations to a "knot"…

  13. Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

    DEFF Research Database (Denmark)

    Hatse, Sigrid; Princen, Katrien; Vermeire, Kurt;

    2003-01-01

    The interaction of the CXCR4 antagonist AMD3100 with its target is greatly influenced by specific aspartate residues in the receptor protein, including Asp(171) and Asp(262). We have now found that aspartate-to-asparagine substitutions at these positions differentially affect the binding of four ...

  14. De novo ring chromosome 3: a new case with a mild phenotype.

    Science.gov (United States)

    McKinley, M; Colley, A; Sinclair, P; Donnai, D; Andrews, T

    1991-08-01

    We report an 18 year old female with a de novo ring chromosome 3 found after investigation for short stature. Her karyotype was interpreted as 46,XX, r(3)(p26.2q29). Her phenotype is milder than previously reported cases and illustrates the mild end of the spectrum of the ring chromosome 3 phenotype.

  15. Impact of National Physical Activity and Health Guidelines and Documents on Research on Teaching K-12 Physical Education in U.S.A.

    Science.gov (United States)

    Li, Weidong; Xiang, Ping; Gao, Zan; Shen, Bo; Yin, Zhihua; Kong, Qingtao

    2016-01-01

    Purpose: This study examined the impact of published national physical activity (PA) and health guidelines, documents, and initiatives on the evolution of research on teaching K-12 physical education (PE) in U.S.A. from 1996 to October 2013. Methods: A total of 262 peer-reviewed, data-based journal articles meeting our inclusion and exclusion…

  16. Polychaete community structure of Indian west coast shelf, Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Joydas, T.V.; Jayalakshmy, K.V.; Damodaran, R.

    . Warwick, R. M., Mar. Ecol. Prog. Ser., 1988, 46, 167–170. 4. Ferraro, S. P. and Cole, F. A., Mar. Ecol. Prog. Ser., 1990, 67, 251–262. 5. Gray, J. S., Clarke, K. R., Warwick, R. M. and Hobbs, G., Mar. Ecol. Prog. Ser., 1990, 66, 285–299. 6. Gesteira...

  17. Training Evaluation: Clients' Roles.

    Science.gov (United States)

    Hashim, Junaidah

    2001-01-01

    A study was conducted of 262 training providers in Malaysia, where providers must be government approved. Government regulation, client demands for high quality, and an economic downturn that focused attention on training costs have all influenced evaluation in a positive direction. (SK)

  18. 45 CFR 204.4 - Grant appeals.

    Science.gov (United States)

    2010-10-01

    ... material necessary. (3) If the response to the grantee is adverse to the grantee's position, the response...) Section 222(a) and (b) of the Social Security Amendments of 1972 (Pub. L. 92-603). (2) Section 426 of the Social Security Act (42 U.S.C. 262). (3) Section 707 of the Social Security Act (42 U.S.C. 907)....

  19. 78 FR 35273 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

    Science.gov (United States)

    2013-06-12

    ... new biological products contain data that are adequate to assess the safety and effectiveness of the... and advertisements for biological products as well as for prescription drugs and antibiotics. The... Service Act (42 U.S.C. 262), manufacturers of biological products must submit a license application...

  20. Who Wants to Be a Mentor? An Examination of Attitudinal, Instrumental, and Social Motivational Components

    Science.gov (United States)

    Van Emmerik, Hetty; Baugh, S. Gayle; Euwema, Martin C.

    2005-01-01

    Purpose: This study investigates the influence of affective organizational commitment, career aspirations, and networking activities on propensity to mentor (serving as a mentor and desiring to become a mentor). Design/methodology/approach: Data from websurveys of 262 managerial employees of a Dutch bank are analyzed using logistic regression.…

  1. Dicty_cDB: SLD662 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available oideum slug cDNA, clone SLB765. 262 e-128 2 ( DL235728 ) NOVEL COMPOSITIONS AND METHODS FOR CANCER. 50 0.039... 1 ( DD164427 ) NOVEL COMPOSITIONS AND METHODS FOR CANCER. 50 0.039 1 ( AX695647 ) Sequence 1274 from Patent

  2. Educational Arrangements and Social Participation with Peers amongst Children with Disabilities in Regular Schools

    Science.gov (United States)

    Wendelborg, Christian; Tossebro, Jan

    2011-01-01

    The purpose of this study is to examine the relationships between educational arrangements and social participation amongst children with disabilities in regular schools. The analysis is based on data drawn from surveys of parents of children with disabilities, aged 11-13, who attend regular schools in Norway (N = 262). We have explored the…

  3. Ethics Perception: Does Teaching Make a Difference?

    Science.gov (United States)

    Nguyen, Nhung T.; Basuray, M. Tom; Smith, William P.; Kopka, Donald; McCulloh, Donald N.

    2008-01-01

    The present study examined student learning in business ethics, particularly ethical judgment, using R. E. Reidenbach and D. P. Robin's (1990) Multidimensional Ethics Scale (MES). The authors asked 262 undergraduate students to provide ethical judgment rating, first at the beginning of the semester and again at the end of the semester. Students…

  4. Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up

    NARCIS (Netherlands)

    F. Liu; M. Visser (Mijke); D.L. Duffy (David); P.G. Hysi (Pirro); L.C. Jacobs (Leonie); O. Lao Grueso (Oscar); K. Zhong (Kaiyin); S. Walsh (Susan); L. Chaitanya (Lakshmi); A. Wollstein (Andreas); G. Zhu (Gu); G.W. Montgomery (Grant); A.K. Henders (Anjali); M. Mangino (Massimo); D. Glass (Daniel); V. Bataille (Veronique); R.A. Sturm (Richard A.); F. Rivadeneira Ramirez (Fernando); A. Hofman (Albert); W.F.J. van IJcken (Wilfred); A.G. Uitterlinden (André); R.-J.T.S. Palstra (Robert-Jan); T.D. Spector (Timothy); N.G. Martin (Nicholas); T.E.C. Nijsten (Tamar); M.H. Kayser (Manfred)

    2015-01-01

    textabstractIn the International Visible Trait Genetics (VisiGen) Consortium, we investigated the genetics of human skin color by combining a series of genome-wide association studies (GWAS) in a total of 17,262 Europeans with functional follow-up of discovered loci. Our GWAS provide the first genom

  5. Prevalence of Fragilysin Gene in Bacteroides fragilis Isolates from Blood and Other Extraintestinal Samples

    OpenAIRE

    Foulon, Ina; Piérard, Denis; Muyldermans, Gaëtan; Vandoorslaer, Kristof; Soetens, Oriane; Rosseel, Paul; Lauwers, Sabine

    2003-01-01

    Of 166 Bacteroides fragilis isolates, 26.2% of 103 isolates from blood and 20.6% of 63 extraintestinal isolates harbored the fragilysin gene (difference not statistically significant). Clinical characteristics and evolution were comparable in patients with B. fragilis bacteremia with or without this enterotoxin. Fragilysin seems not to be an important virulence factor in B. fragilis disease.

  6. 76 FR 66965 - Treasure Coast Specialty Pharmacy Decision and Order

    Science.gov (United States)

    2011-10-28

    ... Aeronautics Bd., 598 F.2d 250, 262 (DC Cir. 1979), cited in Liddy's Pharmacy, L.L.C., 76 FR 48887, 48896, fn... statements. Id. citing Darrell Risner, DMD, 61 FR 728, 730 (1996); Nicholas A. Sychak, d/b/a Medicap Pharmacy, 65 FR 75959, 75961 (2000); John Stafford Noell, 59 FR 47359, 47361 (1994). . Therefore,...

  7. Regulatory Self-efficacy as a Moderator of Peer Socialization Relating to Italian Adolescents' Alcohol Intoxication

    NARCIS (Netherlands)

    Rabaglietti, E.; Burk, W.J.; Giletta, M.

    2012-01-01

    The present study investigated regulatory self-efficacy (RSE) as a predictor of friendship and adolescent alcohol intoxication and as a moderator of peer socialization processes related to alcohol intoxication. The longitudinal sample included 457 Italian adolescents (262 females and 195 males) rang

  8. Beyond Statistical Methods – Compendium of Statistical Methods for Researchers

    Directory of Open Access Journals (Sweden)

    Ondřej Vozár

    2014-12-01

    Full Text Available Book Review: HENDL, J. Přehled statistických metod: Analýza a metaanalýza dat (Overview of Statistical Methods: Data Analysis and Metaanalysis. 4th extended edition. Prague: Portál, 2012. ISBN 978-80-262-0200-4.

  9. Seizure deterioration in women treated with oxcarbazepine during pregnancy

    DEFF Research Database (Denmark)

    Petrenaite, Vaiva; Sabers, Anne; Hansen-Schwartz, Jacob

    2009-01-01

    Thirteen pregnancies in ten women on oxcarbazepine (OXC) monotherapy and one pregnancy in a woman on OXC and topiramate therapy were retrospectively analyzed. A significant decrease of ratio plasma concentration of 10-monohydroxy derivate (MHD) of oxcarbazepine to dosage was found by 26.2% during...

  10. Home Literacy Environments (HLEs) Provided to Very Young Children

    Science.gov (United States)

    Burgess, Stephen R.

    2011-01-01

    The home literacy environment (HLE) provided to very young children was examined. A parent with a child under 19 months of age (N = 262) completed a series of checklists and surveys designed to assess literacy experiences and opportunities within the home. In general, children were exposed to a wide range of literacy activities and experiences,…

  11. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

    DEFF Research Database (Denmark)

    Thiel, S; Steffensen, R; Christensen, I J;

    2007-01-01

    inflammatory actions. We examined human populations for MASP-2 levels, MASP-2 function and for the presence of mutations in coding exons of MASP2. The MASP-2 levels were lowest in Africans from Zambia (median, 196 ng/ml) followed by Hong Kong Chinese (262 ng/ml), Brazilian Amerindians (290 ng/ml) and Danish...

  12. File list: Oth.EmF.10.AllAg.NIHSLASH3T3 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.EmF.10.AllAg.NIHSLASH3T3 mm9 TFs and others Embryonic fibroblast NIH/3T3 SRX262...SRX262783 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.EmF.10.AllAg.NIHSLASH3T3.bed ...

  13. Development of an Instrument for Assessing Senior High School Students' Preferred and Perceived Laboratory Classroom Environment

    Science.gov (United States)

    Hsiao, Chien-Hua; Wu, Ying-Tien; Lin, Chung-Yen; Wong, Terrence William; Fu, Hsieh-Hai; Yeh, Ting-Kuang; Chang, Chung-Yen

    2014-01-01

    This study aimed to develop an instrument, named the inquiry-based laboratory classroom environment instrument (ILEI), for assessing senior high-school science students' preferred and perceived laboratory environment. A total of 262 second-year students, from a senior-high school in Taiwan, were recruited for this study. Four stages were…

  14. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

    DEFF Research Database (Denmark)

    Mangino, Massimo; Hwang, Shih-Jen; Spector, Timothy D;

    2012-01-01

    Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. ...

  15. Exploring the Impact of Learning Objects in Middle School Mathematics and Science Classrooms: A Formative Analysis

    Science.gov (United States)

    Kay, Robin H.; Knaack, Liesel

    2008-01-01

    The current study offers a formative analysis of the impact of learning objects in middle school mathematics and science classrooms. Five reliable and valid measures of effectiveness were used to examine the impact of learning objects from the perspective of 262 students and 8 teachers (14 classrooms) in science or mathematics. The results…

  16. Epistemological Beliefs, Social Status, and School Preference: An Exploration of Relationships

    Science.gov (United States)

    De Brabander, Cornelis J.; Rozendaal, Jeroen S.

    2007-01-01

    This study explored the relations between epistemological beliefs, social status of parents (n = 262), and school preferences. Epistemological beliefs were measured by 20 bi-polar statements. School preferences were derived from paired comparisons of educational quality of available primary schools. Social status was measured in two dimensions,…

  17. Draft Genome Sequence of Toxigenic Corynebacterium ulcerans Strain 03-8664 Isolated from a Human Throat.

    Science.gov (United States)

    Guimarães, Luis C; Viana, Marcus V C; Benevides, Leandro J; Mariano, Diego C B; Veras, Adonney A O; Sá, Pablo H C; Rocha, Flávia S; Vilas Boas, Priscilla C B; Soares, Siomar C; Barbosa, Maria S; Guiso, Nicole; Badell, Edgar; Azevedo, Vasco; Ramos, Rommel T J; Silva, Artur

    2016-01-01

    Corynebacterium ulcerans is an emergent pathogen infecting wild and domesticated animals worldwide that may serve as reservoirs for zoonotic infections. In this study, we present the draft genome of C. ulcerans strain 03-8664. The draft genome has 2,428,683 bp, 2,262 coding sequences, and 12 rRNA genes.

  18. 77 FR 55429 - Fitness-for-Duty Programs

    Science.gov (United States)

    2012-09-10

    ...), PRM-26-2 (64 FR 67205; December 1, 1999), is included in the Regulatory Basis for this proposed rulemaking. This PRM was partially considered in the March 31, 2008 (73 FR 16965), Fitness for Duty Programs final rule. In this proposed rulemaking, the NRC is considering PRM-26-3 (76 FR 28192; May 16,...

  19. Empathetic Responsiveness, Group Norms, and Prosocial Affiliations in Bullying Roles

    Science.gov (United States)

    Nickerson, Amanda B.; Mele-Taylor, Danielle

    2014-01-01

    In this study, the relationships among gender, empathetic responsiveness, perceived group norms, prosocial affiliations, and bullying roles were examined for 262 fifth- through eighth-grade students (n = 141 males; n = 121 females). According to the Bullying Participant Roles Survey (BPRS), participants were identified as defenders (n = 135;…

  20. 78 FR 53757 - Information Collections Being Submitted for Review and Approval to the Office of Management and...

    Science.gov (United States)

    2013-08-30

    ... a High Definition Television (HDTV) program service and 26.2 to identify a Standard Definition... estimate; ways to enhance the quality, utility, and clarity of the information collected; ways to minimize..., giving the name, address and telephone number of the licensee or his service representative to...

  1. On the biomechanics of stem cell niche formation in the gut--modelling growing organoids

    NARCIS (Netherlands)

    Buske, P.; Przybilla, J.; Loeffler, M.; Sachs, N.; Sato, T.; Clevers, H.; Galle, J.

    2012-01-01

    In vitro culture of intestinal tissue has been attempted for decades. Only recently did Sato et al. [Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) Nature 459, 262-265] succeed in establishing

  2. Medical Management of the Transplant Patient: Long-term Follow-up

    OpenAIRE

    Massin, Edward K.

    1987-01-01

    Of the 165 patients who have undergone cardiac transplantation at the Texas Heart Institute since 1982,* 159 long-term survivors have been followed up for an average of 1 year. Here I report on post-transplant complications in both the short and long terms, giving figures and treatment protocols where applicable. (Texas Heart Institute Journal 1987; 14: 262-267)

  3. Retrospective analysis of main and interaction effects in genetic association studies of human complex traits

    DEFF Research Database (Denmark)

    Tan, Qihua; Christiansen, Lene; Brasch-Andersen, Charlotte;

    2007-01-01

    with that of the case-only model. RESULTS: Results from our simulation study indicate that our retrospective model exhibits high power in capturing even relatively small effect with reasonable sample sizes. Application of our method to data from an association study on the catalase -262C/T promoter polymorphism...

  4. Evaluation of fresh pasta-making properties of extra-strong common wheat (Triticum aestivum L.).

    Science.gov (United States)

    Ito, Miwako; Maruyama-Funatsuki, Wakako; Ikeda, Tatsuya M; Nishio, Zenta; Nagasawa, Koichi; Tabiki, Tadashi; Yamauchi, Hiroaki

    2012-12-01

    The relationship between characterictics of flour of common wheat varieties and fresh pasta-making qualitites was examined, and the fresh pasta-making properties of extra-strong varieties that have extra-strong dough were evaluated. There was a positive correlation between mixing time (PT) and hardness of boiled pasta, indicating that the hardness of boiled pasta was affected by dough properties. Boiled pasta made from extra-strong varieties, Yumechikara, Hokkai 262 and Hokkai 259, was harder than that from other varieties and commercial flour. There was a negative correlation between flour protein content and brightness of boiled pasta. The colors of boiled pasta made from Yumechikara and Hokkai 262 grown under the condition of standard manuring culture were superior to those of boiled pasta made from other varieties. Discoloration of boiled pasta made from Yumechikara grown under the condition of heavy manuring culture was caused by increase of flour protein content. On the other hand, discoloration of boiled pasta made from Hokkai 262 grown under the condition of heavy manuring culture was less than that of boiled pasta made from Yumechikara. These results indicate that pasta made from extra-strong wheat varieties has good hardness and that Hokkai 262 has extraordinary fresh pasta-making properties.

  5. Dicty_cDB: CFH580 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available USDA-FP_116000-262 Immature Ovaries from field collected Flying Dragon Trifoliate Orange Poncirus trifoliata...H10 5', mRNA sequence. 62 3e-05 1 CF420765 |CF420765.1 USDA-FP_118000-768 Immature Ovaries from field collected Flying

  6. 76 FR 48166 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2011-08-08

    ... under section 351 of the Public Health Service Act (42 U.S.C. 262). The guidance addresses several types... situation, the license manufacturer should be kept informed of the types or categories of all products..., recalls, postmarket reporting of the dissemination of advertising and promotional labeling materials...

  7. Regulatory Self-Efficacy as a Moderator of Peer Socialization Relating to Italian Adolescents' Alcohol Intoxication

    Science.gov (United States)

    Rabaglietti, Emanuela; Burk, William J.; Giletta, Matteo

    2012-01-01

    The present study investigated regulatory self-efficacy (RSE) as a predictor of friendship and adolescent alcohol intoxication and as a moderator of peer socialization processes related to alcohol intoxication. The longitudinal sample included 457 Italian adolescents (262 females and 195 males) ranging in age of 14 to 20 years (M = 16.1 years of…

  8. Risk Perception, Rape, and Sexual Revictimization: A Prospective Study of College Women

    Science.gov (United States)

    Messman-Moore, Terri L.; Brown, Amy L.

    2006-01-01

    Risk perception was examined in relation to sexual victimization among 262 college women. Participants were presented with written vignettes that described hypothetical situations with a stranger and with an acquaintance. Participants' hypothetical decision to leave a potentially risky situation with an acquaintance predicted rape and…

  9. Influence of high commitment management on organisational performance: human resource flexibility as a mediator variable

    OpenAIRE

    Beltrán Martín, Inmaculada

    2006-01-01

    Tendencies such as the increasing spread of market globalisation, new technological developments, the reduction of product life cycles and aggressive competition, are generating high levels of environmental changes and uncertainty for organisations of all types (Volberda, 1996; Sanchez, 1997). These circumstances require rapid responses through adaptations of organisational attitudes and capabilities, which lead to innovative management approaches and organisational methods (Bueno, 1996: 262)...

  10. 75 FR 77878 - Determination of Regulatory Review Period for Purposes of Patent Extension; FREESTYLE NAVIGATOR

    Science.gov (United States)

    2010-12-14

    ... NAVIGATOR (U.S. Patent No. 5,262,035) from Abbott Diabetes Care Inc., and the Patent and Trademark Office... Patent Extension; FREESTYLE NAVIGATOR AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY... of Commerce, for the extension of a patent which claims that medical device. ADDRESSES:...

  11. 36 CFR 222.23 - Removal of other horses and burros.

    Science.gov (United States)

    2010-07-01

    ... 36 CFR 261.7 and 262.10. ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Removal of other horses and... AGRICULTURE RANGE MANAGEMENT Management of Wild Free-Roaming Horses and Burros § 222.23 Removal of...

  12. Trends in the Employment of College and University Graduates in Business and Industry. Northwestern Endicott Report, 1984. Thirty-eighth Annual Report.

    Science.gov (United States)

    Lindquist, Victor R.; Endicott, Frank S.

    Results of a 1983 survey on policy and practice in the employment of college graduates in 262 well-known business and industrial firms are presented. The number of companies hiring graduates in nine bachelors-level and five masters-level fields are specified for both 1983 and 1984, along with the number of graduates for each field and salary…

  13. Domain Modeling: NP_066574.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_066574.2 chr2 CRYSTAL STRUCTURE OF A DESIGNED ZINC FINGER PROTEIN BOUND TO DNA c1meyf_ chr2/NP_066574.2.../NP_066574.2_holo_254-335.pdb blast 255K,259C,261E,262C,263G,264K,265A,266F,267F,268D

  14. Experiment list: SRX1177351 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available 5265375,84.9,2.7,262 GSM1866124: ChIPseq GBM 2483 H3K4me1.FL152; Homo sapiens; ChIP-Seq source_name=brain || tissue=Gliobmastoma biop...sy http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachD

  15. Why I don't kill myself : [poems] / Paul-Eerik Rummo

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    2003-01-01

    Autori lühitutvustus lk. 262. Sisu: Why I don't kill myself ; The sky stoops over the earth ; Clinging ; Crooning. Orig.: Miks ma end ära ei tapa ; "Taevas on kummargil üle maa..." ; Kinni hoidmas ; Poolüminal

  16. Cardiovascular System

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    6.1.Heart failure2005329 Early impairment of renal function inchronic heart failure and its clinical significance.JINZhengming(金争鸣),et al.Dept Cardiol,The 1st AffiliHosp,Med Coll,Zhejiang Univ,Hangzhou 310003.Chin J Intern Med 2005;44(4):262-264

  17. Coffee Certification in East Africa: Impact on Farmers, Families and Cooperatives

    Directory of Open Access Journals (Sweden)

    Jason Donovan

    2015-08-01

    Full Text Available Reviewed: Coffee Certification in East Africa: Impact on Farmers, Families and Cooperatives. Edited by Ruerd Ruben and Paul Hoebink. Wageningen, the Netherlands: Wageningen Academic Publishers, 2015. 262 pp. US $ 62.00, € 45.00. ISBN 978-90-8686-255-9.

  18. 75 FR 12230 - Black Oak Energy, L.L.C., EPIC Merchant Energy, LP, SESCO Enterprises, LLC v. PJM Interconnection...

    Science.gov (United States)

    2010-03-15

    .... PJM Interconnection, L.L.C.; Notice of Filing March 8, 2010. Take notice that on March 1, 2010, PJM Interconnection, L.L.C. filed a report of refund pursuant to the Federal Energy Regulatory Commission's..., L.L.C., et al. v. PJM Interconnection, L.L.C., 128 FERC ] 61,262 (2009) (September 17 Order)....

  19. 76 FR 60845 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2011-09-30

    ...-R-263, CMS-R-262, CMS- 10142 and CMS-855(O)] Agency Information Collection Activities: Proposed... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... collection of information, including any of the following subjects: (1) The necessity and utility of...

  20. An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD+-Dependent Glutamate Dehydrogenase

    Directory of Open Access Journals (Sweden)

    Joanna Griffin

    2011-01-01

    Full Text Available Sequence and structure comparisons of various glutamate dehydrogenases (GDH and other nicotinamide nucleotide-dependent dehydrogenases have potentially implicated certain residues in coenzyme binding and discrimination. We have mutated key residues in Clostridium symbiosum NAD+-specific GDH to investigate their contribution to specificity and to enhance acceptance of NADPH. Comparisons with E. coli NADPH-dependent GDH prompted design of mutants F238S, P262S, and F238S/P262S, which were purified and assessed at pH 6.0, 7.0, and 8.0. They showed markedly increased catalytic efficiency with NADPH, especially at pH 8.0 (∼170-fold for P262S and F238S/P262S with relatively small changes for NADH. A positive charge introduced through the D263K mutation also greatly increased catalytic efficiency with NADPH (over 100-fold at pH 8 and slightly decreased activity with NADH. At position 242, “P6” of the “core fingerprint,” where NAD+- and NADP+-dependent enzymes normally have Gly or Ala, respectively, clostridial GDH already has Ala. Replacement with Gly produced negligible shift in coenzyme specificity.

  1. Drug: D09984 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available GSFFLYSR LTVDKSRWQE GNVFSCSVMH EALHNHYTQK SLSLSLGK (Disulfide bridge: 22-95; 148-204; 262-322; 368-426, Dimer...QW KVDNALQSGN SQESVTEQDS KDSTYSLSST LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC (Disulfide bridge: 23-88; 136-196; H135-L216, Dimer

  2. Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans

    DEFF Research Database (Denmark)

    Ghisari, Mandana; Long, Manhai; Bonefeld-Jørgensen, Eva Cecilie

    2013-01-01

    . Objectives. The aim of this study was to determine and compare the genotype and allele frequencies of the cytochrome P450 CYP1A1 Ile462Val (rs1048943), CYP1B1 Leu432Val (rs1056836) and catechol-O-methyltransferase COMT Val158Met (rs4680) in Greenlandic Inuit (n=254) and Europeans (n=262) and explore...

  3. 40 CFR 721.10191 - Amides, coco, N-[3-(dibutylamino)propyl].

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Amides, coco, N- . 721.10191 Section... Substances § 721.10191 Amides, coco, N- . (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as amides, coco, N- (PMN P-06-262; CAS No. 851544-20-2)...

  4. 40 CFR 263.10 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Scope. (d) A transporter of hazardous waste subject to the Federal manifesting requirements of 40 CFR... hazardous waste within the United States if the transportation requires a manifest under 40 CFR part 262... water, a transporter who meets all applicable requirements of 49 CFR parts 171 through 179 and...

  5. EST Table: FS897929 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS897929 E_FL_ftes_29A02_R_0 10/09/28 98 %/262 aa ref|NP_001040163.1| ischemia/reperfusion... inducible protein [Bombyx mori] gb|ABD36179.1| ischemia/reperfusion inducible protein [Bombyx mori

  6. Bank competition with product differentiation under different monetary policy rules

    NARCIS (Netherlands)

    Toolsema-Veldman, Linda

    2001-01-01

    After a theoretical overview of factors which could influence aldermen’s use of information, this paper presents some findings of survey research on 262 aldermen of 140 Dutch municipalities with 20,000 or more inhabitants. The findings of the survey indicate that many respondents considered the outp

  7. Human resource practices in multinational companies in Ireland: a large scale survey

    OpenAIRE

    Gunnigle, Patrick; Lavelle, Jonathan; McDonnell, Anthony; Collings, David; Morley, Michael; Turner, Thomas; Wallace, Joseph

    2007-01-01

    Non-peer-reviewed This report represents the largest and most representative empirical investigation of employment practice in MNCs in Ireland to date. Based on face-to-face interviews with senior HR practitioners in some 262 Irish owned and foreign owned MNCs.

  8. Main: IDE2HVIDS2 [PLACE

    Lifescience Database Archive (English)

    Full Text Available IDE2HVIDS2 S000464 24-April-2005 (last modified) kehi IDE2 (iron-deficiency-respons...ive element 2) found at -262/-236 of barley IDS2 (iron deficiency specific clone 2) gene promoter; See also S000463; iron; root; Hordeum vulgare (barley) TTGAACGGCAAGTTTCACGCTGTCACT ...

  9. AcEST: BP914209 [AcEST

    Lifescience Database Archive (English)

    Full Text Available _PONAB U2-associated protein SR140 OS=Pongo abeli... 50 4e-06 sp|Q5BIS6|NR1H2_BOVIN Oxysterols receptor LXR-...SFDDGDPQTTNLYVG 451 PGS D GDP TTNLY+G Sbjct: 262 PGSHDVGDPSTTNLYLG 278 >sp|Q5BIS6|NR1H2_BOVIN Oxysterols rec

  10. GETDB: 112404 [GETDB

    Lifescience Database Archive (English)

    Full Text Available 112404 jockey{}261 297{}262 929 1 FlyBase Insertion: P{GawB}NP0929 y[*] seems to be fixed 20Oct2007 NT. NP l...9 Chr. 1 Comments FlyBase Insertion: P{GawB}NP0929 y[*] seems to be fixed 20Oct20

  11. Alcohol Use, Acculturative Stress, and Drinking Motivation among International Community College Students

    Science.gov (United States)

    Koyama, Chieko; Belli, Gabriella

    2011-01-01

    Alcohol use, acculturative stress, and drinking motivations of 262 students in English as a second language programs in a U.S. community college were explored. Alcohol consumption was generally low, but differences between two groups with different legal statuses indicate the need to consider subgroups of international students for research…

  12. Evaluation of a Florida coastal golf complex as a local and watershed source of bioavailable contaminants

    Science.gov (United States)

    Lewis, Michael A., Robert L. Quarles, Darrin D. Dantin and James C. Moore. 2004. Evaluation of a Coastal Golf Complex as a Local and Watershed Source of Bioavailable Contaminants. Mar. Pollut. Bull. 48(3-4):254-262. (ERL,GB 1183). Contaminant fate in coastal areas impacte...

  13. 48 CFR Appendix F to Chapter 2 - Material Inspection and Receiving Report

    Science.gov (United States)

    2010-10-01

    .... Authority: 41 U.S.C. 421 and 48 CFR chapter 1. Part 1—Introduction F-101General. This appendix contains... gliders, 1550 target drones HQ Air Force Materiel Command, LGX-AVDO, Area A, Building 262, Room N142,...

  14. Dicty_cDB: Contig-U13268-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2/62 (100%) Strand = Plus / Plus Query: 11 gttgantttggattanattaaaaattancnacnaanna...aattaaanntagntanattttt 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 gttgantttgg...= 50/62 (80%) Strand = Plus / Plus Query: 11 gttgantttggattanattaaaaattancnacnaannaaattaaanntagntanattttt 70...entities = 49/62 (79%) Strand = Plus / Plus Query: 11 gttgantttggattanattaaaaattancnacnaannaaattaaanntagntan... Expect(2) = 3e-11 Identities = 61/61 (100%) Strand = Plus / Minus Query: 12 ttgantt

  15. Magnetic Resonance Imaging of Thoracic Aortic Dissections

    OpenAIRE

    Sax, Steven L.

    1990-01-01

    Magnetic resonance imaging is an excellent noninvasive method for evaluating thoracic aortic dissections. A variety of magnetic resonance scans of aortic dissections are shown, documenting the ability of magnetic resonance to image the true lumen, the false channel, and the intimal septum. Detail is provided on magnetic resonance imaging techniques and findings. (Texas Heart Institute Journal 1990;17:262-70)

  16. 40 CFR 273.70 - Imports.

    Science.gov (United States)

    2010-07-01

    ...) Persons managing universal waste that is imported from an OECD country as specified in 40 CFR 262.58(a)(1... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Imports. 273.70 Section 273.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS...

  17. 40 CFR 266.70 - Applicability and requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Applicability and requirements. 266.70 Section 266.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... to or imported from designated OECD member countries for recovery, subpart H of part 262 and §...

  18. 40 CFR 273.20 - Exports.

    Science.gov (United States)

    2010-07-01

    ... to those OECD countries specified in 40 CFR 262.58(a)(1) (in which case the handler is subject to the... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.20 Section 273.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS...

  19. 40 CFR 273.40 - Exports.

    Science.gov (United States)

    2010-07-01

    ... to those OECD countries specified in 40 CFR 262.58(a)(1) (in which case the handler is subject to the... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.40 Section 273.40 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS...

  20. 75 FR 42363 - Public Health Security and Bioterrorism Preparedness and Response Act of 2002; Biennial Review...

    Science.gov (United States)

    2010-07-21

    ... republished the HHS select agent and toxin list in the Federal Register on October 16, 2008 (73 FR 61363). The... HUMAN SERVICES 42 CFR Part 73 RIN 0920-AA34 Public Health Security and Bioterrorism Preparedness and... Bioterrorism Preparedness and Response Act of 2002 (42 U.S.C. 262a) (the Bioterrorism Act) requires...

  1. Performance evaluation of professional managers by local politicians : survey research in Dutch municipalities

    NARCIS (Netherlands)

    Bogt, Henk J. ter

    2002-01-01

    This paper is concerned with performance evaluation of top professional managers by local politicians. Based on the opinions of a small group of experts and a written survey of 262 aldermen, it examines criteria and performance evaluation styles which are used by aldermen of Dutch municipalities - e

  2. Modeling the interactions of a peptide-major histocompatibility class I ligand with its receptors. I. Recognition by two alpha beta T cell receptors

    DEFF Research Database (Denmark)

    Rognan, D; Stryhn, A; Fugger, L;

    2000-01-01

    A three-dimensional model of the complex between an Influenza Hemagglutinin peptide, Ha255-262, and its restricting element, the mouse major histocompatibility complex (MHC) class I molecule, Kk, was built by homology modeling and subsequently refined by simulated annealing and restrained molecular...

  3. Personality and the long-term outcome of first-episode depression

    DEFF Research Database (Denmark)

    Bukh, Jens D; Andersen, Per K; Kessing, Lars V

    2016-01-01

    or outpatients aged 18-70 years with a validated diagnosis of a single depressive episode according to ICD-10 were assessed by the Structured Clinical Interview for DSM-IV Axis II Personality Disorders and the Eysenck Personality Questionnaire from 2005 through 2007. At 5-year follow-up, 262 patients were...

  4. The Relationship of Motivation and Flow Experience to Academic Procrastination in University Students

    Science.gov (United States)

    Lee, Eunju

    2005-01-01

    In this article, the author examined the relationships of motivation and flow experience to academic procrastination in 262 Korean undergraduate students who completed a questionnaire on procrastination, flow, and motivation. The results indicated that high procrastination was associated with lack of self-determined motivation and low incidence of…

  5. 12 CFR 225.24 - Procedures for other nonbanking proposals.

    Science.gov (United States)

    2010-01-01

    ... notice for the Board's prior approval under § 225.21(a) to engage in or acquire a company engaged in a... of Procedure (12 CFR 262.3). (1) Engaging de novo in listed activities. A bank holding company... and the identity of the company that will conduct the activity. (2) Acquiring company engaged...

  6. 12 CFR 225.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... Regarding Delegation of Authority (12 CFR part 265) and the Board's Rules of Procedure (12 CFR part 262). (b... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Administration. 225.3 Section 225.3 Banks and... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions § 225.3...

  7. Evaluation of pulsatility index and diameter of the jugular vein and superficial body temperature as physiological indices of temperament in weaned beef calves: relationship with serum cortisol concentrations, rectal temp..

    Science.gov (United States)

    The relationship between temperament, pulsatility index and diameter of the jugular vein, and body temperature was assessed in Angus crossbred calves (262±24.9 days old). Temperament scores were used to classify calves as calm (n=31), intermediate (n=32), or temperamental (n=28). Blood samples were ...

  8. File list: ALL.Emb.50.AllAg.Embryonic_limb [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.50.AllAg.Embryonic_limb mm9 All antigens Embryo Embryonic limb SRX804047,SR...262,SRX002661,SRX083266,SRX083272 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Emb.50.AllAg.Embryonic_limb.bed ...

  9. The Role of Life Satisfaction and Parenting Styles in Predicting Delinquent Behaviors among High School Students

    Science.gov (United States)

    Onder, Fulya Cenkseven; Yilmaz, Yasin

    2012-01-01

    The purpose of this study is to determine whether the parenting styles and life satisfaction predict delinquent behaviors frequently or not. Firstly the data were collected from 471 girls and 410 boys, a total of 881 high school students. Then the research was carried out with 502 students showing low (n = 262, 52.2%) and high level of delinquent…

  10. 49 CFR 171.3 - Hazardous waste.

    Science.gov (United States)

    2010-10-01

    ... have identification numbers which must be displayed on hazardous waste manifests. See 40 CFR parts 262...: In 40 CFR part 263, the EPA sets forth requirements for the cleanup of releases of hazardous wastes. ... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous waste. 171.3 Section...

  11. Recensión Libro de Adela Cortina: “Neuroética y neuropolítica; Sugerencias para la educación moral”, Tecnos, Madrid 2011

    Directory of Open Access Journals (Sweden)

    Víctor Páramo Valero

    2011-01-01

    Full Text Available Reseña de Adela Cortina, “Neuroética y neuropolítica; Sugerencias para la educación moral”, Tecnos, Madrid, 2011 (1ª ed. septiembre 2011, 2ª ed. diciembre 2011. 262 págs. ISBN: 978-84-309-5321-9.

  12. Who wants to be a mentor? : An examination of attitudinal, instrumental, and social motivational components

    NARCIS (Netherlands)

    Emmerik, IJ. Hetty van; Baugh, S. Gayle; Euwema, Martin C.

    2005-01-01

    Purpose – This study investigates the influence of affective organizational commitment, career aspirations, and networking activities on propensity to mentor (serving as a mentor and desiring to become a mentor). Design/methodology/approach – Data from websurveys of 262 managerial employees of a Dut

  13. Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

    DEFF Research Database (Denmark)

    Rosenkilde, Mette M; Gerlach, Lars-Ole; Jakobsen, Janus S;

    2004-01-01

    , respectively. Metal ion binding in the cyclam rings of AMD3100 increased its dependence on Asp(262) and provided a tighter molecular map of the binding site, where borderline mutational hits became clear hits for the Zn(II)-loaded analog. The proposed binding site for AMD3100 was confirmed by a gradual build...

  14. The anti-apoptotic MAP kinase pathway is inhibited in NIH3T3 fibroblasts with increased expression of phosphatidylinositol transfer protein β

    NARCIS (Netherlands)

    Schenning, M.; van Tiel, C.M.; Wirtz, K.W.A.; Snoek, G.T.

    2007-01-01

    Mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein ß (PI-TPß, SPIß cells) demonstrate a low rate of proliferation and a high sensitivity towards UV-induced apoptosis when compared with wtNIH3T3 cells. In contrast, SPIßS262A cells overexpressing a mutant PI-TPß that la

  15. 76 FR 28626 - Airworthiness Directives; Lockheed Martin Corporation/Lockheed Martin Aeronautics Company Model...

    Science.gov (United States)

    2011-05-18

    ..., 2010 (75 FR 262). That NPRM proposed to require repetitive inspections for any damage of the lower..., which lists only work-hours and appears to have ignored the material and loss of earnings due to...,000 per airplane, per inspection cycle. We partially agree with the commenter's requests to change...

  16. Therapy and the Aesthetics of the Self

    Science.gov (United States)

    Guilfoyle, Michael

    2016-01-01

    Post-structuralists argue that personal identity is a function of societal power dynamics. This becomes especially problematic for persons recruited into problem-saturated identities. In this paper, inspired by Foucault's call for us to "create ourselves as a work of art" (p. 262), I explore the therapeutic value of an aesthetic approach…

  17. 40 CFR 264.573 - Design and operating requirements.

    Science.gov (United States)

    2010-07-01

    ... the residues are hazardous as per 40 CFR 262.11 and, if so, must manage them under parts 261-268, 270... sealed, coated, or covered with a surface material with a hydraulic conductivity of less than or equal to... below the liner to prevent failure of the liner due to settlement, compression or uplift; and...

  18. 40 CFR 267.116 - What must I do with contaminated equipment, structure, and soils?

    Science.gov (United States)

    2010-07-01

    ... that waste following all applicable requirements of 40 CFR part 262. ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What must I do with contaminated... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT Closure § 267.116 What must I do with contaminated...

  19. Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study

    DEFF Research Database (Denmark)

    Winkel, Rikke Rass; von Euler-Chelpin, My Catarina; Nielsen, Mads;

    2015-01-01

    impact reproducibility has on relative risk estimates of breast cancer. METHODS: This retrospective case-control study included 122 cases and 262 age- and time matched controls (765 breasts) based on a 2007 screening cohort of 14,736 women with negative screening mammograms from Bispebjerg Hospital...

  20. Factors Associated with Service Use among Immigrants in the Child Welfare System

    Science.gov (United States)

    Rajendran, Khushmand; Chemtob, Claude M.

    2010-01-01

    This study investigated child, caregiver, and caseworker factors associated with greater use of family support services by immigrant families in the U.S. child welfare system. Among child factors, higher levels of internalizing behavior problems (Odds Ratio (O.R.) = 3.60), externalizing behavior problems (O.R. = 2.62) and a history of neglect…

  1. Association of human papillomavirus infection with other microbial pathogens in gynecology%人乳头状瘤病毒与妇科其他常见病原微生物感染关系的调查

    Institute of Scientific and Technical Information of China (English)

    郑美云; 赵荷兰; 狄君平; 林干; 林颖; 林曦; 郑敏巧

    2010-01-01

    Objective To Investigate correlation between screening assay of human papillomavirus (HPV) and microbial pathogens in gynecology. Methods Cervical samples were collected to search for HPV, bacteria and yeast infections in gynecologic outpatients. HPV typing was carried out by PCR and sequencing on cervical brush specimens. Chlamydia trachomatis was identified by strand displacement amplification (SDA) and the other microorganisms were detected by conventional methods. All data were analyzed to investigate the correlation among them. Results In this cross-sectional study, among 857 enrolled outpatients, there were 266 cases with positive HPV DNA, and the rate of infection was 31.0%(266/857). HPV genotype showed that thirty-five different HPV types were identified, of which HPV16 was the most prevalent ( 14.5%, 38/262), followed by HPV58 (9.2%, 24/262), HPV53 (8.0%, 21/262)and HPV42 (6.1%, 16/262); while other genotypes were present in less than 5% of HPV positive women.According to the reclassification, the aggregated percentage (high-risk and probably high-risk) of detected HPV was 58.8% ( 154/262), 27.9% (73/262) for low-risk and 13.4% (35/262) for unknown-risk HPV types. Among HPV positive women, cervical brush specimens results showed that more than 60% cases with normal cytology, 3.8% (10/266) with high-grade squamous intraepithelial lesions (HSIL), 29. 7% (79/266) with low-grade squamous intraepithelial lesions (LSIL) and 3.0% (8/266) with atypical squamous cells of undetermined significance (ASCUS), respectively. Statistical analyses revealed there was a significant association between the infected HPV and Chlamydia trachomatis or Ureaplasma urealyticum ( >10000 CCU/ml; all P 0.05 ). Among the cases with bacterial vaginosis, the positive rate of HPV infected was42.6%. Chlamydia trachomatis was one of the high-risk factors for the infection of HPV ( OR = 2.82, 95%CI: 1.74 -4.57). Mycoplasma hominis was isolated only in 2 cases, no patient was infected with

  2. Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L., in in vitro and in vivo assays

    Directory of Open Access Journals (Sweden)

    Teixeira Rosangela de Oliveira

    2003-01-01

    Full Text Available The use of medicinal plants by the general population is an old and still widespread practice, which makes studies of their genotoxicity essential. Psidium guajava L. and Achillea millefolium L. are examples of plants commonly used in popular medicine. P. guajava L. is indicated for diarrhea and also as an antiseptic, while A. millefolium L. is indicated as an analgesic, antispasmodic, digestive, diuretic, antiseptic, astringent, emollient, wound healer and hemorrhoid medication. The aim of this study was to determine the effects of the infusions of these two plant species on chromosomes and the cell cycle. Leaves from the plants were used to prepare infusions, in the same manner as teas, but at two different concentrations. Allium cepa L. root-tip cells (P. guajava L. - 2.62 and 26.2 mg/mL, and A. millefolium L. - 3.5 and 35.0 mg/mL and Wistar rat bone marrow cells (P. guajava L. - 2.62 and 26.2 mg/100g body weight, and A. millefolium L. - 3.5 and 35.0 mg/100g body weight were used as in vivo plant and animal test systems, respectively. Human peripheral blood lymphocytes (P. guajava L. - 0.262 and 2.62 mg/mL culture medium, and A. millefolium L. - 0.35 and 3.5 mg/mL culture medium were used as in vitro test system. The P. guajava L. infusion at the higher concentration caused a statistically significant inhibition of cellular division in the onion root-tip cells, not observed in onion root-tip cells treated with A. millefolium L. No statistically significant alterations were found, as compared to untreated controls, in either the cell cycle or the number of chromosome alterations, after treatments with either plant, in rat cells or in cultured human lymphocytes. These results regarding the cytotoxicity and mutagenicity of these plants provide valuable information about the safety of using them as therapeutic agents.

  3. 七氟醚麻醉对淀粉样前蛋白转基因小鼠认知功能及海马神经元Tau蛋白磷酸化水平的影响%Effect of sevoflurane anesthesia on cognitive function and phosphorylation of tau protein in hippocampal neurons in amyloid precursor protein transgenic mice

    Institute of Scientific and Technical Information of China (English)

    李长生; 刘素芳; 吕帅国

    2014-01-01

    Objective To investigate the effect of sevoflurane anaesthesia on the cognitive function and phosphorylation of tau protein in hippocampal neurons in amyloid precursor protein (APP) transgenic mice.Methods Male APP gene mutation mice,weighing 18-22 g and aged 8-12 weeks,were used in this study.Forty-four APP positive mice were randomly divided into two groups:sevoflurane group (group AS,n =28) and control group (group AC,n =16).And other forty-four APP negative mice were randomly divided into two groups:sevoflurane group (group S,n =28) and control group (group C,n =16).The animals in groups S and AS inhaled 3% sevoflurane for 4 hours.While in groups C and AC,the animals inhaled pure oxygen for 4 hours.Morris water maze was performed 24 hours after sevoflurane or pure oxygen inhalation.The phosphorylation of tau protein at Ser262 and Ser396 sites was detected by Western blotting on 1 day after pure oxygen inhalation in groups AC and C,and on 1,3 and 7 days after sevoflurane inhalation in groups AS and S.Results Compared with group C,the escape latency was significantly prolonged and the duration of staying at the original platform quadrant was shortened in groups S and AC,and the phosphorylation of tau protein at Ser262 site in group S and phosphorylation of tau protein at Ser262 and Ser396 sites in group AS were increased (P < 0.05).Compared with group S,the escape latency was significantly prolonged,the duration of staying at the original platform quadrant was shortened,and the phosphorylation of tau protein at Ser262 and Ser396 sites was increased in group AS (P < 0.05).Compared with group AC,the escape latency was significantly prolonged,the duration of staying at the original platform quadrant was shortened,and the phosphorylation of tau protein at Ser262 and Ser396 sites was increased in group AS (P<0.05).Conclusion Sevoflurane anesthesia can aggravate the impairment of cognitive function in APP positive mice and the increase in the phosphorylation of

  4. On the approximate maximum likelihood estimation for diffusion processes

    CERN Document Server

    Chang, Jinyuan; 10.1214/11-AOS922

    2012-01-01

    The transition density of a diffusion process does not admit an explicit expression in general, which prevents the full maximum likelihood estimation (MLE) based on discretely observed sample paths. A\\"{\\i}t-Sahalia [J. Finance 54 (1999) 1361--1395; Econometrica 70 (2002) 223--262] proposed asymptotic expansions to the transition densities of diffusion processes, which lead to an approximate maximum likelihood estimation (AMLE) for parameters. Built on A\\"{\\i}t-Sahalia's [Econometrica 70 (2002) 223--262; Ann. Statist. 36 (2008) 906--937] proposal and analysis on the AMLE, we establish the consistency and convergence rate of the AMLE, which reveal the roles played by the number of terms used in the asymptotic density expansions and the sampling interval between successive observations. We find conditions under which the AMLE has the same asymptotic distribution as that of the full MLE. A first order approximation to the Fisher information matrix is proposed.

  5. Financial crisis and criminality in Greece: 2008 vs 2011.

    Science.gov (United States)

    Tsouvelas, G; Kontaxakis, V; Giotakos, O; Konstantakopoulos, G; Kontaxaki, M-I; Papaslanis, Th

    2016-01-01

    Α number of previous articles have dealt with the negative impact of the Greek Economic crisis on public health, including significant increases in major depression prevalence and suicide and homicide rates. The mentally ill seem to represent a vulnerable social group, with particular difficulties in this context. The number of compulsory assessments and involuntary admissions was recorded by reviewing patient records in the Department of Psychiatry of the University Hospital of Patras, through years 2006-2013. Compulsory assessments increased from 176 in 2006 to 262 in 2009 and 354 in 2013, representing a 48.86% and 101.13% increase in the first and the fifth year of economic crisis, respectively. The assessments resulted in 160 involuntary admissions in 2006, which escalated to 262 admissions (63.75% rise) in 2013. Even though a rise in involuntary placements could be attributed to other factors as well, it may also partly represent a not so evident side of the Greek economic crisis.

  6. A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

    Science.gov (United States)

    Jing, Maofeng; Guo, Baodian; Li, Haiyang; Yang, Bo; Wang, Haonan; Kong, Guanghui; Zhao, Yao; Xu, Huawei; Wang, Yan; Ye, Wenwu; Dong, Suomeng; Qiao, Yongli; Tyler, Brett M.; Ma, Wenbo; Wang, Yuanchao

    2016-01-01

    Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes. PMID:27256489

  7. Zoladex plus flutamide vs. orchidectomy for advanced prostatic cancer. Danish Prostatic Cancer Group (DAPROCA)

    DEFF Research Database (Denmark)

    Iversen, P

    1990-01-01

    The study comprised 262 patients with previously untreated advanced carcinoma of the prostate. Patients were randomized either to undergo orchidectomy or to receive combined treatment with Zoladex, 3.6 mg every 4 weeks, plus flutamide, 250 mg t.i.d. At present the median follow-up is 39 months. T......' with Zoladex plus flutamide was not clinically superior to orchidectomy in the treatment of patients with advanced prostatic cancer.......The study comprised 262 patients with previously untreated advanced carcinoma of the prostate. Patients were randomized either to undergo orchidectomy or to receive combined treatment with Zoladex, 3.6 mg every 4 weeks, plus flutamide, 250 mg t.i.d. At present the median follow-up is 39 months. The...

  8. Dissipative soliton resonance in a full polarization-maintaining fiber ring laser at different values of dispersion.

    Science.gov (United States)

    Armas-Rivera, I; Cuadrado-Laborde, C; Carrascosa, A; Kuzin, E A; Beltrán-Pérez, G; Díez, A; Andrés, M V

    2016-05-01

    We investigated the dissipative solitons resonance in an ytterbium-doped fiber ring laser in which all the elements are polarization maintaining (PM). A semiconductor saturable absorber mirror was used as a mode-locker. The cavity included a normal dispersion single-mode fiber (SMF) and an anomalous dispersion photonic crystal fiber. The change of the length of the PM SMF allows the variation of the net-normal dispersion of the cavity in the range from 0.022 ps2 to 0.262 ps2. As the absolute value of the net-normal dispersion increases from 0.022 ps2 to 0.21 ps2, a square-shaped single pulse transformed to a single right-angle trapezoid-shaped pulse, and, at the dispersion of 0.262 ps2, to multiple right-angle trapezoid-shaped pulses, per round-trip. PMID:27137606

  9. Low temperature phase transformations in 4-cyano-4'-pentylbiphenyl (5CB) filled by multiwalled carbon nanotubes

    OpenAIRE

    Lebovka, N.; Melnyk, V.; Mamunya, Ye.; Klishevich, G.; Goncharuk, A.; Pivovarova, N.

    2013-01-01

    The effects of multiwalled carbon nanotubes (NTs) on low-temperature phase transformations in 5CB were studied by means of differential scanning calorimetry (DSC), low-temperature photoluminescence and measurements of electrical conductivity. The concentration of NTs was varied within 0-1% wt. The experimental data, obtained for pure 5CB by DSC and measurements of photoluminescence in the heating mode, evidenced the presence of two crystallization processes at T->229 K and T->262 K, which cor...

  10. Identification and evolutionary genomics of novel LTR retrotransposons in Brassica

    OpenAIRE

    NOUROZ, FAISAL; NOREEN, SHUMAILA; HESLOP-HARRISON, JOHN SEYMOUR

    2015-01-01

    Abstract: Retrotransposons (REs) are the most abundant and diverse elements identified from eukaryotic genomes. Using computational and molecular methods, 262 intact LTR retrotransposons were identified from Brassica genomes by dot plot analysis and data mining. The Copia superfamily was dominant (206 elements) over Gypsy (56), with estimated intact copies of ~1596 Copia and 540 Gypsy and ~7540 Copia and 780 Gypsy from Brassica rapa and Brassica oleracea whole genomes, respectively. Canonical...

  11. Sulfur cycle

    Digital Repository Service at National Institute of Oceanography (India)

    LokaBharathi, P.A.

    Ecological Society Symposium held jointly with the Linnean Society of London. Oxford: Blackwell. Huston MH and Smith T (1987) Plant succession: Life history and competition. American Naturalist 130: 168–198. Sulfur Cycle P A Loka Bharathi, National Institute.... Vegetatio 110: 115–147. Odum EP (1969) The strategy of ecosystem development. Science 164: 262–270. Walker KR and Alberstadt LP(1975) Ecological succession asan aspect of structure in fossil communities. Paleobiology 1: 238–257. Author's personal copy S 4 O...

  12. Valitsuse sotsiaalpoliitika viib pankrotti / Eiki Nestor

    Index Scriptorium Estoniae

    Nestor, Eiki, 1953-

    2002-01-01

    Ilmunud ka: Meie Maa, Koit, Vooremaa 1. aug. lk. 2,6,2, Nädaline 3.august lk. 4, Põhjarannik ; Severnoje Poberezhje 2. august lk. 2, Valgamaalane 3. august lk. 2, Molodjozh Estonii 5. august lk. 3, Hiiu Leht 6. august lk. 2, Järva Teataja 8. august lk. 2, Virumaa Teataja 10. august lk. 11, Võrumaa Teataja 10. august lk. 2. Sotsiaalministeeriumi 2003. a. eelarvekavast. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik

  13. Gestion communale du patrimoine arboré non forestier : aperçu des moyens disponibles

    OpenAIRE

    Paul R.; Toussaint A.; Campanella B.; Empain C.

    2008-01-01

    Urban tree management in walloon municipalities: overview of available means. A survey has been sent in 2006 to the 262 municipalities from Wallonia concerning their green areas management and particularly focused on local arboricultural heritage. The questionnaire was structured by 3 themes: (1) the managed heritage, (2) economical and technical means available for municipalities, (3) available management tools. Fifty-three answers have been gathered which represent 20.2%. This enquiry gives...

  14. Basin-scale partitioning of Greenland ice sheet mass balance components (2007-2011)

    DEFF Research Database (Denmark)

    Andersen, M.L.; Stenseng, Lars; Skourup, Henriette;

    2015-01-01

    of the gate. Using a 1961-1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007-2011 mean D of 515±57 Gtyr-1. We find a 2007-2011 mean total mass balance of -262±21 Gtyr-1, which is equal to a 0.73 mm yr-1 global sea...

  15. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: A randomised, double-blind placebo-controlled study

    OpenAIRE

    Stan Vlaicu; Tubelius Py; Zachrisson Anders

    2005-01-01

    Abstract Background Short term illnesses, usually caused by respiratory or gastrointestinal diseases are disruptive to productivity and there is relatively little focus on preventative measures. This study examined the effect of the probiotic Lactobacillus reuteri protectis (ATCC55730) on its ability to improve work-place healthiness by reducing short term sick-leave caused by respiratory or gastrointestinal infections. Methods 262 employees at TetraPak in Sweden (day-workers and three-shift-...

  16. Karm otsus : kas palgatõus või topeltpalk? / Tõnis Lukas

    Index Scriptorium Estoniae

    Lukas, Tõnis, 1962-

    2003-01-01

    Ilmunud ka: Võrumaa Teataja, Koit, Hiiumaa 13. september lk. 2,6,2, Põhjarannik, Severnoje Poberezhje 12. september lk. 2, Lääne Elu 16. september lk. 4, Meie Maa 17. september lk. 2, Nädaline, Vooremaa 18. september lk. 4,2, Sakala 24. september lk. 2, Hiiu Leht, Pärnu Postimees 30. september lk. 2,15. Riigikogu liige kritiseerib valitsuskoalitsiooni poliitikat, mis ei taga õpetajatele palgatõusu

  17. Otto Speck: Die Ökonomisierung sozialer Qualität. Zur Qualitätsdiskussion in Behindertenhilfe und Sozialer Arbeit. München/Basel: Reinhardt 1999. [...] [Sammelrezension

    OpenAIRE

    Hornstein, Walter

    2000-01-01

    Sammelrezension von: 1. Otto Speck: Die Ökonomisierung sozialer Qualität. Zur Qualitätsdiskussion in Behindertenhilfe und Sozialer Arbeit. München/Basel: Reinhardt 1999. 241 S. 2. Ewald Johannes Brunner/Petra Bauer/Susanne Volkmar (Hrsg.): Soziale Einrichtungen bewerten. Theorie und Praxis der Qualitätssicherung. Freiburg i.Br.: Lambertus 1998. 262 S. 3. Wassilios E. Fthenakis/Martin Textor (Hrsg.): Qualität von Kinderbetreuung. Konzepte, Forschungsergebnisse, internationaler Vergleich. (Jahr...

  18. Hyaluronidase production in Streptococcus milleri in relation to infection.

    OpenAIRE

    Unsworth, P F

    1989-01-01

    One hundred and seven (41%) of 262 isolates of Streptococcus milleri, from human sources, produced hyaluronidase. Hyaluronidase production was commoner in beta haemolytic isolates 32 of 39 (82%), many of which were of Lancefield group F. But hyaluronidase was also found in alpha and non-haemolytic isolates, and in groups A, C, G, and non-groupable isolates. There was a strong association between hyaluronidase production and isolation from known internal abscesses (48/58, 83%) compared with is...

  19. Do Investors See Through Accounting Profitability and Recognize Efficiency? Evidence from Chinese Listed Companies

    OpenAIRE

    Wenjuan Xie

    2013-01-01

    This paper studies the accounting performance measure, profit efficiency and investor valuation of 1,262 Chinese firms listed in Shanghai and Shenzhen Stock Exchanges from 2001 to 2010. Profit efficiency is defined as the ratio of actual profit realized to the optimal profit described by stochastic frontier approach. An estimation of robust ordinary least square model for accounting performance measures (ROA) controlling for industry effect results in negative skewness of the residuals, indic...

  20. Antibiotic Resistance in Animal and Environmental Samples Associated with Small-Scale Poultry Farming in Northwestern Ecuador

    OpenAIRE

    Braykov, Nikolay P.; Eisenberg, Joseph N. S.; Grossman, Marissa; Zhang, Lixin; Vasco, Karla; CEVALLOS, WILLIAM; Muñoz, Diana; Acevedo, Andrés; Moser, Kara A.; Marrs, Carl F.; Foxman, Betsy; Trostle, James; Trueba, Gabriel; Levy, Karen

    2016-01-01

    ABSTRACT The effects of animal agriculture on the spread of antibiotic resistance (AR) are cross-cutting and thus require a multidisciplinary perspective. Here we use ecological, epidemiological, and ethnographic methods to examine populations of Escherichia coli circulating in the production poultry farming environment versus the domestic environment in rural Ecuador, where small-scale poultry production employing nontherapeutic antibiotics is increasingly common. We sampled 262 “production ...

  1. Rehabilitation after anterior cruciate ligament injury influences joint loading during walking but not hopping

    OpenAIRE

    Risberg, May Arna; MOKSNES, HÅVARD; Storevold, Annika; Holm, Inger; Snyder-Mackler, Lynn

    2009-01-01

    Objective: The purpose of this study was to identify changes in clinical outcome and lower extremity biomechanics during walking and hopping in ACL-injured subjects before and after a 20-session neuromuscular and strength training programme. Study design: Pre and post experimental design. Setting: Outpatient clinic, primary care. Patients: 32 subjects with unilateral ACL injury, mean 60 (SD 35) days after injury, with a mean age of 26.2 (5.4) years. Intervention: The rehabilitation programme ...

  2. Thoughts on Structure Adjustment of China's Refining Industry and Recommendations on Improving Economy of Scale

    Institute of Scientific and Technical Information of China (English)

    Cao Xianghong

    2002-01-01

    @@By the end of 1998 China boasted 220 refineries with a totalcrude processing capacity of 262 Mt/a. The average refinerysize at that time was 1.194 Mt/a. Refineries with processingcapacity exceeding 5.0 Mt/a accounted for only 21.26%,while the capacity of single refining units were also smallthat could not conform with the economy of scale. China'srefining industry is faced with a tough task of structureadjustment.   

  3. Thoughts on Structure Adjustment of China's Refining Industry and Recommendations on Improving Economy of Scale

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ By the end of 1998 China boasted 220 refineries with a totalcrude processing capacity of 262 Mt/a. The average refinerysize at that time was 1.194 Mt/a. Refineries with processingcapacity exceeding 5.0 Mt/a accounted for only 21.26%,while the capacity of single refining units were also smallthat could not conform with the economy of scale. China'srefining industry is faced with a tough task of structureadjustment.

  4. Work Engagement and Workaholism: Comparing the Self-Employed and Salaried Employees

    OpenAIRE

    Gorgievski-Duijvesteijn, Marjan; Bakker, Arnold; Schaufeli, Wilmar

    2010-01-01

    textabstractAbstract: This study among a Dutch convenience sample of self-employed individuals (n = 262) and salaried employees (n = 1900) tested to what extent workaholism and work engagement relate to self-reported work performance. After controlling for measurement inequivalence, results of structural equation modelling showed that the self-employed score higher on engagement and working excessively then employees, but not on working compulsively. In addition, work engagement related posit...

  5. Maternal Personality, Parenting Cognitions and Parenting Practices

    OpenAIRE

    Bornstein, Marc H.; Hahn, Chun-Shin; Haynes, O. Maurice

    2011-01-01

    A community sample of 262 European American mothers of firstborn 20-month-olds completed a personality inventory and measures of parenting cognitions (knowledge, self-perceptions, and reports about behavior) and was observed in interaction with their children from which measures of parenting practices (language, sensitivity, affection, and play) were independently coded. Factor analyses of the personality inventory replicated extraction of the Five-Factor model of personality (Openness, Neuro...

  6. EST Table: NM_001126256 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available NM_001126256 Slp 10/09/29 100 %/262 aa ref|NP_001119728.1| hemolymph protein [Bomby...x mori] dbj|BAA02093.1| hemolymph protein [Bombyx mori] 10/09/13 n.h 10/08/29 n.h 10/09/10 n.h 10/09/10 n.h 10/09/10 n.h FS791687 ...

  7. Stock Selection Strategies in Emerging Markets

    OpenAIRE

    Hart, J; Slagter, Erica; van Dijk, Dick

    2001-01-01

    This discussion paper resulted in a publication in 'Emerging Markets Review', 2005, 6, 238-262. See also the publication in the 'Journal of Empirical Finance', 2003, 10, 1-5=132. Recent empirical evidence suggests that value and momentum strategies generate significantexcess returns in emerging markets. We confirm these results and extend them in severaldirections. First, we examine a broader range of stock selection strategies, including strategiesbased on analysts' earnings revisions. We al...

  8. [sup 13]C NMR on C[sub 60] single-crystal. RMN du [sup 13]C sur un monocristal de C[sub 60

    Energy Technology Data Exchange (ETDEWEB)

    Kerkoud, R.; Auban-Senzier, P.; Godard, J.; Jerome, D. (Paris-11 Univ., 91 - Orsay (France). Lab. de Physique des Solides); Lambert, J.M.; Bernier, P. (Montpellier-1 Univ., 34 (France))

    1994-01-01

    The authors report a [sup 13]C NMR study performed on a C[sub 60] single crystal (8% enriched in [sup 13]C) grown by sublimation. Molecular motions are tested by spin-lattice relaxation data and spectral shapes below and above the structural transition at T[sub c] = 262 K. The sharpness of this transition and the long relaxation times at low temperature, compared to previous data on powdered samples, confirm the high purity of the crystal.

  9. Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

    OpenAIRE

    Lin, Ying-Ju; Chang, Jeng-Sheng; Liu, Xiang(Research Center for Hadron and CSR Physics, Lanzhou University and Institute of Modern Physics of CAS, 730000, Lanzhou , China); Tsang, Hsinyi; Lin, Ting-Hsu; Liao, Chiu-Chu; Huang, Shao-Mei; Chien, Wen-Kuei; Chen, Jin-Hua; Wu, Jer-Yuarn; Chen, Chien-Hsiun; Chang, Li-Ching; Lin, Cheng-Wen; Ho, Tsung-Jung; Tsai, Fuu-Jen

    2014-01-01

    Background Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility ...

  10. Association between GRIN3A Gene Polymorphism in Kawasaki Disease and Coronary Artery Aneurysms in Taiwanese Children

    OpenAIRE

    Ying-Ju Lin; Jeng-Sheng Chang; Xiang Liu; Chien-Hui Hung; Ting-Hsu Lin; Shao-Mei Huang; Kuan-Teh Jeang; Chia-Yen Chen; Chiu-Chu Liao; Cheng-Wen Lin; Chih-Ho Lai; Ni Tien; Yu-Ching Lan; Mao-Wang Ho; Wen-Kuei Chien

    2013-01-01

    Kawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A (GRIN3A) in KD, we investigated genetic variations in GRIN3A in a Taiwanese cohort of 262 KD patients (76 with and 186 without CAA compl...

  11. Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline.

    OpenAIRE

    Hall, Sharon M.; Gorecki, Julie A; Victor I. Reus; Humfleet, Gary L.; Muñoz, Ricardo F.

    2007-01-01

    This study assessed the relationship between beliefs about drug assignment and abstinence status in two treatment studies using nortriptyline hydrochloride as an adjunct to smoking cessation. Smokers (N = 345) drawn from two clinical trials were asked at the final follow-up (FFU) at 52 or 64 weeks whether they believed they had received active or placebo drug. Responses were obtained from 262 participants, or 76% of the sample. Biochemically verified abstinence was collected at end of treatme...

  12. Learning Compact Visual Attributes for Large-Scale Image Classification

    OpenAIRE

    Su, Yu; Jurie, Frédéric

    2012-01-01

    International audience Attributes based image classification has received a lot of attention recently, as an interesting tool to share knowledge across different categories or to produce compact signature of images. However, when high classification performance is expected, state-of-the-art results are typically obtained by combining Fisher Vectors (FV) and Spatial Pyramid Matching (SPM), leading to image signatures with dimensionality up to 262,144 [1]. This is a hindrance to large-scale ...

  13. Effect of Fertilization on Soil Fertility and Wheat Yield of Dryland in the Loess Plateau

    Institute of Scientific and Technical Information of China (English)

    HAO Ming-De; FAN Jun; WEI Xiao-Rong; PEN Lin-Fa; LAI Lu

    2005-01-01

    Long-term fertility experiments have become an important tool for investigating the sustainability of cropping systems.Therefore, a long-term (18-year) fertilization experiment was conducted in Changwu County, Shaanxi Province, China,to ascertain the effect of the long-term application of chemical fertilizers and manure on wheat yield and soil fertility in the Loess Plateau, so as to provide a scientific basis for sustainable land management. The experiment consisted of nine fertilizer treatments with three replicates arranged in a completely randomized design: 1) CK (no fertilizer); 2) N (N 120 kg ha-i); 3) P (P 26.2 kg ha-1); 4) NP (N 120, P 26.2 kg ha-1); 5) M (manure 75 t ha-1); 6) NM (N 120 kg ha-1,manure 75 t ha-1); 7) PM (P 26.2 kg ha-1, manure 75 t ha-1); 8) NPM (N 120, P 26.2 kg ha-1, manure 75 t ha-1);and 9) fallow (no fertilizer, no crop). N fertilizer was applied in the form of urea and P was applied as calcium super phosphate. The results showed that precipitation had a large effect on the response of wheat yield to fertilization. Manure (M), NP, PM, NM, and NPM treatments significantly increased (P < 0.05) average yield. In the NP, PM, NM and NPM treatments, the percentage increases in yield due to fertilization were highest in normal years, and lowest in the drought years. Long-term P application enhanced soil available P markedly, and manure applications contributed more to soil fertility than chemical fertilizers alone. Chemical fertilizers applied together with manure distinctly improved soil fertility.The results also showed that the soil nutrient concentration changed mainly in the 0-60 cm layers and fertilization and planting only slightly affected soil nutrients below the 100 cm layers.

  14. Birth Weight, Postnatal Growth, and Age at Menarche

    OpenAIRE

    Terry, Mary Beth; Ferris, Jennifer S.; Tehranifar, Parisa; Wei, Ying; Flom, Julie D.

    2009-01-01

    Larger body size in childhood is correlated with earlier age at menarche; whether birth and infant body size changes are also associated with age at menarche is less clear. The authors contacted female participants enrolled in the New York site of the US National Collaborative Perinatal Project born between 1959 and 1963 (n = 262). This racially and ethnically diverse cohort (38% white, 40% African American, and 22% Puerto Rican) was used to investigate whether maternal (body size, pregnancy ...

  15. Comparison of written reports of mammography, sonography and magnetic resonance mammography for preoperative evaluation of breast lesions, with special emphasis on magnetic resonance mammography

    OpenAIRE

    Malur, Sabine; Wurdinger, Susanne; Moritz, Andreas; Michels, Wolfgang; Schneider, Achim

    2000-01-01

    Patients with abnormal breast findings (n = 413) were examined by mammography, sonography and magnetic resonance (MR) mammography; 185 invasive cancers, 38 carcinoma in situ and 254 benign tumours were confirmed histologically. Sensitivity for mammography was 83.7%, for sonography it was 89.1% and for MR mammography it was 94.6% for invasive cancers. In 42 patients with multifocal invasive cancers, multifocality had been detected by mammography and sonography in 26.2%, and by MR mammography i...

  16. Psychological, Social, and Environmental Factors Associated With Utilization of Senior Centers Among Older Adults in Korea

    OpenAIRE

    Kim, Hyun-Shik; Miyashita, Masashi; Harada, Kazuhiro; PARK, JONG-HWAN; So, Jae-Moo; Nakamura, Yoshio

    2012-01-01

    Objectives The purpose of the study was to examine the relationships among the psychological, social, and environmental factors influencing the utilization of senior centers among older adults in Korea. Methods A questionnaire survey was administered to two types of older adults who lived in Seoul, Korea: 262 older adults who used senior centers (3 places) and 156 older adults who did not use senior centers. Results Our results showed clearly that the utilization of the senior centers in Kore...

  17. STUDY ON OXYTETRACYCLINE RESIDUES IN COW’S MILK SAMPLES COLLECTED IN TETOVO, MACEDONIA FROM 2012 TO 2013

    OpenAIRE

    Kamberi, Mensur; Sulaj, Kapllan

    2014-01-01

    The objective of this study was to determine the oxytetracycline residues in cow’s milk collected in farms of Tetovo in Macedonia. The cow’s milk samples produced in this area are controlled applying qualitative analytical tests for oxitetracycline residues in 262 milk samples through specific ELISA test. After this control positive milk samples were kept in freezing conditions to be analyzed by high performance liquid chromatography (HPLC) method in order to perform qualitative evaluation of...

  18. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.

    OpenAIRE

    SATO, Tsutomu; Kouda, Masanori; HOSHINO, Tsutomu; 佐藤, 努

    2004-01-01

    To provide insight into the catalytic mechanism for the final deprotonation reaction of squalene-hopene cyclase (SHC) from Alicyclobacillus acidocaldarius, mutagenesis experiments were conducted for the following ten residues: Thr41, Glu45, Glu93, Arg127, Trp133, Gln262, Pro263, Tyr267, Phe434 and Phe437. An X-ray analysis of SHC has revealed that two types of water molecules ("front water" and "back waters") were involved around the deprotonation site. The results of these mutagenesis experi...

  19. The CANSURVIVOR Project : meeting post-treatment cancer survivors’ needs

    OpenAIRE

    Ivers, Mary E.; Dooley, Barbara A.; Bates, Ursula

    2009-01-01

    Cancer survivor numbers in Ireland are increasing due to the success of modern treatments. Although most survivors have a good quality of life not all survivors return to 'normal' after treatment. The HSE funded CANSURVIVOR research project has found that many survivors have difficulties and need help to recover and adjust after cancer treatment. Over a number of exploratory studies using interviews, focus groups and a survey of 262 breast, prostate, colorectal and lung cancer survivors, the ...

  20. EST Table: FS896014 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS896014 E_FL_ftes_20I10_R_0 10/09/28 46 %/262 aa ref|XP_974065.1| PREDICTED: similar to Outer dense fiber... protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber pro...DICTED: similar to Outer dense fiber protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber protein) (Cenexin) [Tribolium castaneum] FS893448 ftes ...

  1. Cerebrovascular disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008482 Risk factors for ischemic lacunar stroke associated headache. HU Wei(胡伟), et al. Dept Neurol, Nanjing General Hosp, Nanjing Milit Command, Nanjing 210002. Chin J Nerv Ment Dis 2008;34(5):262-265. Objective To analyze risk factors of stroke-associated headache (SH) and explore its underlying mechanisms. Methods First-ever lacunar infarction patients (n=371) were extracted from Nanjing Stroke Registration Program.

  2. Bezpečnost a ochrana zdraví při práci v podmínkách konkrétního subjektu

    OpenAIRE

    Skopový, Václav

    2013-01-01

    This thesis addresses occupational safety and health. The first part briefly explains the historical development and national policies regarding occupational safety and health in the Czech Republic. A significant part of the thesis analyzes the most important legal regulations that deal with the field of occupational safety and health. In particular law no. 262/2006 Sb. of the Labour Code, which represents the basic piece of legislation that deals with occupational safety and health. Mention ...

  3. Social anxiety disorder in genuine halitosis patients

    OpenAIRE

    Zaitsu Takashi; Ueno Masayuki; Shinada Kayoko; Wright Fredrick A; Kawaguchi Yoko

    2011-01-01

    Abstract Background There is a possibility that genuine halitosis patients' anxiety do not recover after oral malodor treatment due to their social anxiety disorder. The objective of this study was to investigate the influence of social anxiety disorder on the level of anxiety in genuine halitosis patients before and after treatment for oral malodor. Methods The subjects were 262 genuine halitosis patients who visited the Fresh Breath Clinic from March, 2008 to October, 2009. The subjects who...

  4. Multiple Measures of Physical Activity, Dietary Habits and Weight Status in African American and Hispanic or Latina Women

    OpenAIRE

    Lee, Rebecca E; Mama, Scherezade K.; Medina, Ashley V; Reese-Smith, Jacqueline Y; Banda, Jorge A.; Layne, Charles S.; Baxter, Meggin; O’Connor, Daniel P; McNeill, Lorna; Estabrooks, Paul A.

    2011-01-01

    Compared measures of physical activity and dietary habits used in the Health Is Power (HIP) study, and described the associations of physical activity and dietary habits among African American and Hispanic or Latino women, adjusted for weight status. Cross-sectional baseline data were compared for community dwelling, healthy African American (N = 262) and Hispanic or Latina women (N = 148) who participated in HIP. Physical activity was measured using the International Physical Activity Questi...

  5. Four novel algal virus genomes discovered from Yellowstone Lake metagenomes

    OpenAIRE

    Weijia Zhang; Jinglie Zhou; Taigang Liu; Yongxin Yu; Yingjie Pan; Shuling Yan; Yongjie Wang

    2015-01-01

    Phycodnaviruses are algae-infecting large dsDNA viruses that are widely distributed in aquatic environments. Here, partial genomic sequences of four novel algal viruses were assembled from a Yellowstone Lake metagenomic data set. Genomic analyses revealed that three Yellowstone Lake phycodnaviruses (YSLPVs) had genome lengths of 178,262 bp, 171,045 bp, and 171,454 bp, respectively, and were phylogenetically closely related to prasinoviruses (Phycodnaviridae). The fourth (YSLGV), with a genome...

  6. Association of size at birth with adolescent hormone levels, body size and age at menarche: relevance for breast cancer risk

    OpenAIRE

    Opdahl, S.; Nilsen, T I L; Romundstad, P R; Vanky, E; Carlsen, S M; Vatten, L J

    2008-01-01

    Birth size has been positively associated with age at menarche and height in adolescence and adulthood, but the relevant biological mechanisms remain unclear. Among 262 Norwegian term-born singleton girls, birth size measures (weight, length, ponderal index, head circumference and subscapular skin-fold thickness) were analysed in relation to adolescent hormone levels (oestradiol, prolactin, dehydroepiandrosterone sulphate, androstenedione and free testosterone index), age at menarche and adol...

  7. The Multidimensional Prognostic Index (MPI), Based on a Comprehensive Geriatric Assessment, Predicts Short- and Long-Term Mortality in Hospitalized Older Patients with Dementia

    OpenAIRE

    Pilotto, Alberto; Sancarlo, Daniele; Panza, Francesco; Paris, Francesco; D’Onofrio, Grazia; Cascavilla, Leandro; Addante, Filomena; Seripa, Davide; Solfrizzi, Vincenzo; Dallapiccola, Bruno; Franceschi, Marilisa; Ferrucci, Luigi

    2009-01-01

    Aim of this study was to evaluate the usefulness of a Multidimensional Prognostic Index (MPI) based on a Comprehensive Geriatric Assessment (CGA) for predicting mortality risk in older patients with dementia. The present was a retrospective study with a year of follow-up that included 262 patients aged 65 years and older with a diagnosis of dementia. A standardized CGA that included information on clinical, cognitive, functional, and nutritional aspects, as well as comorbidity, medications, a...

  8. Willingness to Express Emotions to Caregiving Spouses

    OpenAIRE

    Monin, Joan K.; Martire, Lynn M.; Schulz, Richard; Clark, Margaret S.

    2009-01-01

    This study examined the association between care-recipients’ willingness to express emotions to spousal caregivers and caregiver’s well-being and support behaviors. Using self-report measures in the context of a larger study, 262 care-recipients with osteoarthritis reported on their willingness to express emotions to caregivers, and caregivers reported on their stress and insensitive responding to care-recipients. Results revealed that care-recipients’ willingness to express happiness was ass...

  9. Erythrocyte and erythrocyte function

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    2005245 Study on genetic diagnosis and prenatal diagnosis of α-thalassemia. LIU Jing-zhong(刘敬忠), et al. Center Gene Diag& Gene Ther, Beijing Chaoyang Hosp,Cap Med Univ,Beijing 100020. Chin J.Hematol ,2005; 26(2): 103-105. Objective: To develop a single-tube multiplex polymerase chain reaction (mPCR) technique to detect three common deletional α-thalassemias (α-Thal)

  10. 25 CFR 101.11 - Interest.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Interest. 101.11 Section 101.11 Indians BUREAU OF INDIAN... § 101.11 Interest. (a) The interest to be charged on loans by the United States shall be at a rate... Act of 1974 (Pub. L. 93-262, 88 Stat. 77). The interest rate shall be determined monthly and shall...

  11. Energy availability and the female athlete triad in elite endurance athletes

    DEFF Research Database (Denmark)

    Melin, Anna Katarina; Tornberg, Å B; Skouby, Sven O.;

    2015-01-01

    women [26.2 ± 5.5 years, body mass index (BMI) 20.6 ± 2.0 kg/m(2) , body fat 20.0 ± 3.0%], exercising 11.4 ± 4.5 h/week, were recruited from national teams and competitive clubs. Protocol included gynecological examination; assessment of bone health; indirect respiratory calorimetry; diet and exercise...

  12. Congenital nystagmus and central hypothyroidism

    OpenAIRE

    Reynaert, Nele; Braat, Elke; de Zegher, Francis

    2015-01-01

    We observed a male newborn with bilateral nystagmus and central hypothyroidism without hypoprolactinemia due to a deletion of chromosome band Xq26.1q26.2, containing FRMD7 and IGSF1. These two loss-of function mutations are known to cause, respectively, congenital nystagmus and the ensemble of central hypothyroidism, hypoprolactinemia and testicular enlargement. These latter two features may not yet be present in early life.

  13. Evaluation of Muscle Strength Among Different Sports Disciplines: Relevance for Improving Sports Performance

    OpenAIRE

    Singh, SC; Chengappa, R; Banerjee, A.

    2002-01-01

    A pilot cross-sectional study among 262 service sportsmen belonging to different sports disciplines was carried out to evaluate various indicators of muscle strength, such as peak torque, peak torque to weight, time to peak torque, maximum power, explosive work etc., using isokinetic testing during flexion and extension of the knee joint in sitting positions at different angles. It was found that peak torque varied significantly among the various sports disciplines depending on the requiremen...

  14. Fluid intake from beverages in Spanish adults: cross-sectional study

    OpenAIRE

    Cíntia Ferreira-Pêgo; Nancy Babio; Juan Miguel Fenández-Alvira; Iris Iglesia; Luis A. Moreno; Jordi Salas-Salvadó

    2014-01-01

    Introduction: Dietary questionnaires usually only assess the intake of drinks that provide calories, but do not accurately evaluate total fluid or water intake. The evaluation of the fluid consumption pattern of a population has been the main objective of only a very few studies. Objective: To evaluate the total fluid intake from different types of beverages in Spanish adults. Methods: A total of 1,262 adults aged 18-70 years were randomly recruited from all Spanish regions. The information a...

  15. Low-dose budesonide treatment reduces severe asthma-related events in patients with infrequent asthma symptoms at baseline

    DEFF Research Database (Denmark)

    Reddel, H. K.; Busse, W. W.; Pedersen, Søren;

    2015-01-01

    .6%), >1-2 for 3040 (42.6%) participants. Time to first SARE was longer for budesonide compared with placebo (hazard ratio: 0.57 [95% CI: 0.41, 0.79] for both 0-2 and >2 groups). SARE rates/1000 person-years over 3 years for budesonide versus placebo were 15.4 vs 23.5, 17.5 vs 26.2, and 20.2 vs 40...

  16. Genetic data for 17 Y-chromosomal STR loci in Macedonians in the Republic of Macedonia.

    Science.gov (United States)

    Jakovski, Zlatko; Nikolova, Ksenija; Jankova-Ajanovska, Renata; Marjanovic, Damir; Pojskic, Naris; Janeska, Biljana

    2011-08-01

    The population data were obtained for the 16 Y chromosomal STR loci included in the AmpFistr(®)Yfiler™ PCR Amplification Kit (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385 a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y-GATA H4, DYS437, DYS438, DYS448) in a sample of 262 unrelated men from the Republic of Macedonia. PMID:21549657

  17. Flourishing Technology Development for China's Petroleum Industry

    Institute of Scientific and Technical Information of China (English)

    Fu Chengde; Liu Bingyi

    1994-01-01

    @@ Glimpse of Science andTechnology With over 40 years of development history, a rather complete package system for petroleum research and development has formed. The system includes geological study, oil and gas exploration as well as petroleum machinery etc. There are 262research institutions in CNPC at three different levels (CNPCheadquarters, oilfields headquarters and subsidiaries of oilfields). About 42 021 personnel are directly involved in research and development.

  18. Domain Modeling: NP_060741.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_060741.3 chr2 Crystal Structure of Threonine Synthase from Escherichia coli c1vb3a_ chr2/NP_060741.3.../NP_060741.3_holo_12-441.pdb blast 112F,113K,140G,141T,142S,143G,144D,145T,146G,199D,220L,221N,222S,223I,227R,231Q,262A,313A,321N KPA 0 ...

  19. Cloning and surface expression of Pseudomonas aeruginosa O antigen in Escherichia coli.

    OpenAIRE

    Goldberg, J B; Hatano, K; Meluleni, G S; Pier, G B

    1992-01-01

    As a step toward developing recombinant oral vaccines, we have explored the feasibility of expression of O polysaccharide antigens from Pseudomonas aeruginosa by Escherichia coli. We cloned in E. coli HB101 a 26.2-kilobase DNA fragment from P. aeruginosa strain PA103 that specifies the production of the O polysaccharide of Fisher immunotype 2 (IT-2) strains. The recombinant organism incorporated the P. aeruginosa IT-2 O polysaccharide onto the core of the E. coli lipopolysaccharide (LPS). Tra...

  20. Probabilities and energies to obtain the counting efficiency of electron-capture nuclides, KLMN model

    International Nuclear Information System (INIS)

    An intelligent computer program has been developed to obtain the mathematical formulae to compute the probabilities and reduced energies of the different atomic rearrangement pathways following electron-capture decay. Creation and annihilation operators for Auger and X processes have been introduced. Taking into account the symmetries associated with each process, 262 different pathways were obtained. This model allows us to obtain the influence of the M-electron-capture in the counting efficiency when the atomic number of the nuclide is high

  1. Patient characteristics affecting attendance at general outpatient clinics.

    OpenAIRE

    McClure, R J; Newell, S J; Edwards, S

    1996-01-01

    A study was carried out to identify the characteristics of children who do not attend appointments at general outpatient clinics. Over six months, 359 children who had an appointment at a general clinic were studied using a questionnaire given to parents (74% response rate) and by inspection of case notes. Based on their first appointment in the study period, children were divided into 'attenders' (n = 262) and 'non-attenders' (n = 97) for analysis. Non-attenders were significantly more likel...

  2. Disability and motorcycle taxi drivers in Cartagena, Colombia

    OpenAIRE

    Yaneth Herazo B; Regina Domínguez A; Sandra Olarte B; Liliseth Quitian C

    2011-01-01

    Objective: to estimate the functional dependency as a measure of disability in a group of motorcycle taxi drivers from Cartagena, Colombia. Methods: a retrospective descriptive study in which researchers reviewed 1123 files of motorcycle taxi drivers involved in traffic accidents in Cartagena during 2006. The level of functional dependence regarding performance of some basic activities of daily life was determined for 262 subjects using the Barthel scale. Furthermore, data analysis was carr...

  3. Use of Social Media in Facilitating Health Care Research Among Nursing and Allied Health Undergraduates in Sri Lanka.

    Science.gov (United States)

    Silva, S N

    2016-01-01

    A mentoring program was designed to promote conduction, completion and dissemination of undergraduate research among Nursing and Allied Health students in Sri Lanka. Several social media platforms were used; mainly the Facebook, YouTube and Google Hangouts. Knowledge sharing, interaction and collaboration were promoted. Student motivation was also done. Research presentation skills and applying for conferences was also facilitated. Over 90% of the participated 262 students completed a research project and close to 50% presented them both locally and internationally. PMID:27332276

  4. 糖尿病周围神经痛发病机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    徐湘; 许岚

    2011-01-01

    @@ 糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病常见并发症之一,在糖尿病患者中发病率约20%,占糖尿病神经病变的50%[1],其中糖尿病周围神经痛(painful diabetic peripheral neuropathy,PDN)发病率13%~26%[2].

  5. Evaluation of the antigenic relatedness and cross-protective immunity of the neuraminidase between human influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus.

    Science.gov (United States)

    Lu, Xiuhua; Liu, Feng; Zeng, Hui; Sheu, Tiffany; Achenbach, Jenna E; Veguilla, Vic; Gubareva, Larisa V; Garten, Rebecca; Smith, Catherine; Yang, Hua; Stevens, James; Xu, Xiyan; Katz, Jacqueline M; Tumpey, Terrence M

    2014-04-01

    To determine the genetic and antigenic relatedness as well as the cross-protective immunity of human H1N1 and avian H5N1 influenza virus neuraminidase (NA), we immunized rabbits with either a baculovirus-expressed recombinant NA from A/Beijing/262/95 (BJ/262) H1N1 or A/Hong Kong/483/97 (HK/483) H5N1 virus. Cross-reactive antibody responses were evaluated by multiple serological assays and cross-protection against H5N1 virus challenge was evaluated in mice. In a neuraminidase inhibition (NI) test, the antisera exhibited substantial inhibition of NA activity of the homologous virus, but failed to inhibit the NA activity of heterologous virus. However, these antisera exhibited low levels of cross-reactivity measured by plaque size reduction, replication inhibition, single radial hemolysis, and ELISA assays. Passive immunization with HK/483 NA-specific antisera significantly reduced virus replication and disease, and afforded almost complete protection against lethal homologous virus challenge in mice. However, passive immunization with BJ/262 (H1N1) NA-specific antisera was ineffective at providing cross-protection against lethal H5N1 virus challenge and only slightly reduced weight loss. Substantial amino acid variation among the NA antigenic sites was observed between BJ/262 and HK/483 virus, which was consistent with the lack of cross-reactive NI activity by the antibody and limited cross-protective immunity in mice. These results show a strong correlation between the lack of cross-protective immunity and low structural similarities of NA from a human seasonal H1N1 virus and an avian H5N1 influenza virus.

  6. Uji Resistensi Beberapa Kultivar Plasma Nutfah Karet (Hevea brasiliensis Muell Arg) Terhadap Penyakit Gugur Daun (Corynespora cassiicola (Berk. & Curt.) Wei) Di Lapangan

    OpenAIRE

    Tari Elvalianda

    2009-01-01

    Penelitian ini dilaksanakan di Pusat Penelitian Perkebunan Sungei Putih dari bulan September 2006 sampai bulan Maret 2007. Tujuan penelitian ini adalah untuk mendapatkan kultivar karet yang tahan terhadap penyakit gugur daun (Corynespora cassiicola). Penelitian menggunakan Rancangan Acak Kelompok ( RAK ) Faktorial dengan 60 perlakuan kombinasi dan 2 ulangan. Kultivar plasma nutfah yang digunakan adalah PN No. 262, PN No. 266, PN No. 386, PN No. 389, PN No. 398, PN No. 803...

  7. Differentiation of Pancreatic Cancer and Chronic Pancreatitis Using Computer-Aided Diagnosis of Endoscopic Ultrasound (EUS) Images: A Diagnostic Test

    OpenAIRE

    Maoling Zhu; Can Xu; Jianguo Yu; Yijun Wu; Chunguang Li; Minmin Zhang; Zhendong Jin; Zhaoshen Li

    2013-01-01

    BACKGROUND: Differentiating pancreatic cancer (PC) from normal tissue by computer-aided diagnosis of EUS images were quite useful. The current study was designed to investigate the feasibility of using computer-aided diagnostic (CAD) techniques to extract EUS image parameters for the differential diagnosis of PC and chronic pancreatitis (CP). METHODOLOGY/PRINCIPAL FINDINGS: This study recruited 262 patients with PC and 126 patients with CP. Typical EUS images were selected from the sample set...

  8. Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study

    OpenAIRE

    Lindqvist, Ebba K; Goldin, Lynn R.; Landgren, Ola; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Turesson, Ingemar; Wahlin, Anders; Björkholm, Magnus; Kristinsson, Sigurdur Y.

    2011-01-01

    The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditi...

  9. OPPORTUNITY OF GOODWILL DEPRECIATION IN EMERGING MARKETS

    OpenAIRE

    Radu-Daniel LOGHIN

    2015-01-01

    In order to influence the decisions of the users of financial situations, the financial data concerning the commercial fund must be communicated in an opportune manner. Information like depreciation and amortization must comprise the changes from the competitive environment of the enterprise. The work aims at developing such a model for the evaluation of the opportunity of decision of the commercial fund at the level of 262 bursary titles from the emergent markets, showing that this decision ...

  10. The Fact Book 1994-95. A Statistical Handbook.

    Science.gov (United States)

    Maryland State Dept. of Education, Baltimore.

    This handbook presents statistics about the public and private schools of Maryland. In 1994 there were 790,938 public school students and 156,582 nonpublic school students in the state, representing a 13.2% increase in public schools over 5 years and a 17% growth in the nonpublic schools. There were 1,262 public schools in 1994-95 and 1,024…

  11. Gender and age differences in prevalence and incidence of child sexual abuse in Croatia

    OpenAIRE

    Ajduković, Marina; Sušac, Nika; Rajter, Miroslav

    2013-01-01

    Aim To examine age and gender differences in the prevalence and incidence of child sexual abuse, the level of acquaintance of the child and the perpetrator, and correlations between experiencing family violence and sexual abuse on a nationally representative sample of 11, 13, and 16 years old children. Method A probabilistic stratified cluster sample included 2.62% of the overall population of children aged 11 (n = 1223), 13 (n = 1188), and 16 (n = 1233) from 40 primar...

  12. Imunohistochemistry: detection of microcystin in tilápia exposed to Microcystis aeruginosa (Cyanobacteria) extract/
    Imunoistoquímica: detecção de microcistina em tilápia exposta ao extrato de Microcystis aeruginosa (Cyanobacteria)

    OpenAIRE

    Ken-ichi Harada; Satoshi Nagata; Tomoaki Tsutsumi; Ossamu Kawamura; Eiko Nakagawa Itano; Ilce Mara Syllos Colus; Maria do Carmo Bittencourt-Oliveira; Ana Paula Frederico Rodrigues Loureiro Bracarense; Camilla Guiotti de Pádua; Aniê Ieda Francabandiera; Ana Paula Millet; Elisabete Hiromi Hashimoto; Márcia Kamogae; Yoshio Ueno; Elisa Yoko Hirooka

    2007-01-01

    The deterioration of the water quality due to aquaculture is associated with eutrophication, with bloom of cyanobacteria. Microcystis aeruginosa is distinguished as main producer of microcystins (MCs), group of hepatotoxins with tumor promoter potential. In the present work immunohistochemical method for detection of MC in tilápia (Oreochromis niloticus), fish submitted to intraperitoneal injection (i.p.) or immersion in extract of M. aeruginosa BCCBUSP 262 was developed, using monoclonal ant...

  13. Characterizing the Solvated Structure of Photoexcited [Os(terpy)2]2+ with X-ray Transient Absorption Spectroscopy and DFT Calculations

    DEFF Research Database (Denmark)

    Zhang, Xiaoyi; Pápai, Mátyás Imre; Møller, Klaus Braagaard;

    2016-01-01

    ,2':6',2″-terpyridine) solvated in methanol. From the EXAFS analysis, the structural changes can be characterized by a slight overall expansion of the first coordination shell [OsN6]. DFT calculations supports the XTA results. They also provide additional information about the nature of the molecular orbitals...... that contribute to the optical spectrum (with TD-DFT) and the near-edge region of the X-ray spectra....

  14. New records of three species of nematodes in Cerdocyon thous from the Brazilian Pantanal wetlands.

    Science.gov (United States)

    Gomes, Ana Paula Nascimento; Olifiers, Natalie; Santos, Michele Maria Dos; Simões, Raquel de Oliveira; Maldonado Júnior, Arnaldo

    2015-01-01

    We report the occurrence of nematodes collected from the gut of roadkilled crab-eating foxes (two adult males and one juvenile female), Cerdocyon thous (Linnaeus, 1766), found on the BR 262 highway in Mato Grosso do Sul state, Brazil in 2011. Three helminth species were identified: Ancylostoma buckleyi, Pterygodermatites (Multipectines) pluripectinata, and Ascaridia galli. These nematodes are reported for the first time to infect C. thous from the Brazilian Pantanal wetlands, thereby expanding their geographical distribution. PMID:26444063

  15. Entre o Demasiado Literal e o Excessivamente Literário: Potencialidades e Limites do Tacto Háptico

    Directory of Open Access Journals (Sweden)

    Marques, Diogo

    2016-03-01

    Full Text Available Review of Matthew FULKERSON, The First Sense. A Philosophical Study of the Human Touch.Cambridge, M.A. & London: The MIT Press, 2014, 236 pp. ISBN 978-0-262-01996-5 Review of Alberto GALLACE & Charles SPENCE, In Touch with the FUTURE: the sense of touch from cognitive neuroscience to virtual reality. Oxford: Oxford University Press, 2014, 480 pp. ISBN 978-0-19-964446-9

  16. High Precision Thermal Ionization Mass Spectrometric Dating of Corals and Its Application to Paleo—Environmental Study

    Institute of Scientific and Technical Information of China (English)

    王兆荣; 张兆峰; 等

    2001-01-01

    Global change has become a hot spot in Quaternary geology,and high-precision,high-sensitivity dating is also an urgent problem which needs to be solved.This paper presents some achievements in U-servies dating of marine corals by thermal ionization mass spectrometry (TIMS) and its application to the study of paleo-environments.Recently,coral samples were determined for their ages on a MAT-262 mass spectrometer and satisfactory results have been obtained.

  17. High Precision Thermal Ionization Mass Spectrometric Dating of Corals and Its Application to Paleo-Environmental Study

    Institute of Scientific and Technical Information of China (English)

    王兆荣; 张兆峰; 彭子成; 马志邦

    2001-01-01

    Global change has become a hot spot in Quaternary geology, and high-precision,high-sensitivity dating is also an urgent problem which needs to be solved. This paper presents some achievements in U-series dating of marine corals by thermal ionization mass spectrometry (TIMS) and its application to the study of paleo-environments. Recently, coral samples were determined for their ages on a MAT-262 mass spectrometer and satisfactory results have been obtained.

  18. Genome-Wide Study of Pseudomonas aeruginosa Outer Membrane Protein Immunogenicity Using Self-Assembling Protein Microarrays▿ †

    OpenAIRE

    Montor, Wagner R.; Huang, Jin; Hu, Yanhui; Hainsworth, Eugenie; Lynch, Susan; Kronish, Jeannine-Weiner; Ordonez, Claudia L.; Logvinenko, Tanya; Lory, Stephen; LaBaer, Joshua

    2009-01-01

    Pseudomonas aeruginosa is responsible for potentially life-threatening infections in individuals with compromised defense mechanisms and those with cystic fibrosis. P. aeruginosa infection is notable for the appearance of a humoral response to some known antigens, such as flagellin C, elastase, alkaline protease, and others. Although a number of immunogenic proteins are known, no effective vaccine has been approved yet. Here, we report a comprehensive study of all 262 outer membrane and expor...

  19. Knowledge, Attitudes and Practices Relevant to Malaria Control in Remote Island Populations of Manus, Papua New Guinea

    OpenAIRE

    Ataka, Yuji; Inaoka, Tsukasa; Ohtsuka, Ryutaro

    2011-01-01

    A community-based cross-sectional survey of 262 participants in four island communities of Manus, Papua New Guinea was conducted using a structured questionnaire to examine possible factors of malaria prevalence, including education experiences, knowledge, attitudes, and preventive behaviors, in relation to antimalarial antibody titers. Bivariate and multivariate analyses revealed that micro-environmental conditions caused inter-community differences in malaria prevalence. Ninety-nine percent...

  20. Long-range charge transfer in biopolymers

    Science.gov (United States)

    Astakhova, T. Yu; Likhachev, V. N.; Vinogradov, G. A.

    2012-11-01

    The results of theoretical and experimental studies on the charge transfer in biopolymers, namely, DNA and peptides, are presented. Conditions that ensure the efficient long-range charge transport (by several tens of nanometres) are considered. The known theoretical models of charge transfer mechanisms are discussed and the scopes of their application are analyzed. Attention is focused on the charge transport by the polaron mechanism. The bibliography includes 262 references.

  1. The strong enhancer element in the immediate early region of the human cytomegalovirus genome

    OpenAIRE

    Boshart, Michael; Weber, Frank; Rüger, Rüdiger; Dorsch-Häsler, Karoline; Jahn, Gerhard; Stoerker, Jay; Schaffner, Walter; Fleckenstein, Bernhard

    1985-01-01

    The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-like recombinant viruses , each containing HCMV DNA fragments that were substituting for the missing SV40 enhancer. The two inserts , 341 and 262 bp in length , are overlapping segments of genuine viral DNA representing ...

  2. Screening and monitoring of auto-immune thyroid disease (AITD) during early pregnancy in Shenzhen city

    International Nuclear Information System (INIS)

    Objective: To screen the incidence of AITD in early pregnant women and provide necessary intervention. Methods: Serum TSH (with CLIA) and TPO-Ab (with RIA) levels were measured in 262 pregnant women during 12-20 wks gestation. FT3 and FT4 levels were further determined in the following subjects: (1) TSH 2.8-5.5μIU/ml with positive TPO-Ab (n=7) (2) TSH > 5.5 μIU/ml with positive (n=5) or negative (n=2) TPO-Ab and (3) TSH4 levels were low-normal. We believed that early intervention was desirable and LT4 were administered. In all the seven women with TSH levels above 5.5μIU/ml (TPO-Ab positive in 5 of them), the FT4 levels were lower than normal and would be designated as subclinical hypothyroidism. LT4 treatment was given. Besides, 2 subjects with TPO-Ab positive and TSH levels below 0.35μIU/ml had high FT3 and FT4 levels and received propyl thiouracil treatment as cases of subclinical hyperthyroidism. Therefore, intervention was implemented in 16 cases altogether. Conclusion: In this study, the incidence of AITD in 262 early pregnant women was 3.44% (9/262, 7 subclinical hypothyroidism and 2 subclinical hyperthyroidism). General screening for AITD during early pregnancy seems to be desirable. (authors)

  3. Evidence of multiple reassortment events of feline-to-human rotaviruses based on a rare human G3P[9] rotavirus isolated from a patient with acute gastroenteritis.

    Science.gov (United States)

    Nguyen, Tinh Huu; Than, Van Thai; Thanh, Hien Dang; Kim, Wonyong

    2016-06-01

    A rare human/feline-like rotavirus G3P[9] strain, CAU14-1-262, from a 2-year-old girl with severe gastroenteritis was isolated and sequenced. The 11 gene segments of the CAU14-1-262 strain possessed a novel genotype constellation, G3-P[9]-I3-R3-C3-M3-A3-N3-T1-E3-H6, which was identified for the first time. Phylogenetic analysis of this strain identified the following genome origins: VP7, VP4, VP6, VP1-VP3, NSP1, NSP2, and NSP4 genes possessed an AU-1-like genotype 3 constellation with high sequence identity to those of the feline and human/feline-like rotaviruses; NSP5 possessed a H6 lineage, with highest sequence identity to the human/feline-like E2541 strain; and the NSP3 gene possessed a Wa-like genotype 1 constellation with high sequence identity to those of the of human rotaviruses. These results provided evidence of multiple reassortment events in G3P[9] rotavirus CAU14-1-262 and possibility of feline-to-human interspecies transmission. PMID:27260811

  4. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    Science.gov (United States)

    2016-07-15

    Acute Biphenotypic Leukemia; Acute Erythroid Leukemia in Remission; Acute Leukemia in Remission; Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Acute Myeloid Leukemia in Remission; Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1; Acute Myeloid Leukemia With Inv(3)(q21q26.2); RPN1-EVI1; Acute Myeloid Leukemia With Multilineage Dysplasia; Acute Myeloid Leukemia With t(6;9)(p23;q34); DEK-NUP214; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Complete Remission; B Acute Lymphoblastic Leukemia With t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1); B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1; Burkitt Lymphoma; Childhood Acute Lymphoblastic Leukemia in Complete Remission; DS Stage II Plasma Cell Myeloma; DS Stage III Plasma Cell Myeloma; Myelodysplastic Syndrome; Recurrent Anaplastic Large Cell Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Hodgkin Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma; Secondary Acute Myeloid Leukemia; T Lymphoblastic Lymphoma

  5. Lactobacillus sicerae sp. nov., a lactic acid bacterium isolated from Spanish natural cider.

    Science.gov (United States)

    Puertas, Ana Isabel; Arahal, David R; Ibarburu, Idoia; Elizaquível, Patricia; Aznar, Rosa; Dueñas, M Teresa

    2014-09-01

    Strains CUPV261(T) and CUPV262 were isolated from ropy natural ciders of the Basque Country, Spain, in 2007. Cells are Gram-stain positive, non-spore-forming, motile rods, facultative anaerobes and catalase-negative. The strains are obligately homofermentative (final product dl-lactate) and produce exopolysaccharides from sucrose. Phylogenetic analysis based on 16S rRNA gene sequences revealed that the highest similarity to both isolates corresponded to the type strain of Lactobacillus vini (99.1 %), followed by Lactobacillus satsumensis (96.4 %), and Lactobacillus oeni (96.2 %), and for all other established species, 16S rRNA gene sequence similarities were below 96 %. The species delineation of strains CUPV261(T) and CUPV262 was evaluated through RAPD fingerprinting. In addition, a random partial genome pyrosequencing approach was performed on strain CUPV261(T) in order to compare it with the genome sequence of Lactobacillus vini DSM 20605(T) and calculate indexes of average nucleotide identity (ANI) between them. Results permit the conclusion that strains CUPV261(T) and CUPV262 represent a novel species of the genus Lactobacillus, for which the name Lactobacillus sicerae sp. nov. is proposed. The type strain is CUPV261(T) ( = CECT 8227(T) = KCTC 21012(T)).

  6. 大孔吸附树脂精制栀子黄色素的梯度洗脱和拐点控制%The Gardenia Yellow Refined through the Grads Elution and the Inflection Point Control of the Macropore Absorption Resin

    Institute of Scientific and Technical Information of China (English)

    廖湘萍; 林英; 李世杰; 肖传英

    2009-01-01

    Four macropore resins were selected for gardenia yellow refining by absorption and elution to remove impure matter. The water elution turn point and lower degree ethenol elution turn point were studied and controlled. Combined with reverse grads elution technology,the gardenia yellow product had refined with A_(325nm)/A_(440nm)=0.187,A_(238nm)/A_(440nm)=0,A_(262nm)/A_(440nm)= 0.220. The product recovery of refining was higher than 90%.%筛选了应用较广的4种大孔吸附树脂YW、NKA、D3520、HPD-100A进行栀子黄色素的吸附分离精制,研究了精制过程中水和低度乙醇洗脱除杂的拐点控制,结合采用反梯度洗脱工艺,得到栀子黄色素产品分别在440nm、325nm和262nm有吸收峰,计算其吸光度比值A_(325nm)/A_(440nm)=0.187,A_(283nm)/A_(440nm)=0.000,A_(262nm)/A_(440nm)=0.220,产品精制回收率皆可超过90%.

  7. Recombination of an intrachromosomal paracentric insertion of chromosome 3

    Energy Technology Data Exchange (ETDEWEB)

    Best, R.G.; Burnett, W.J.; Brock, J.K. [Univ. of South Carolina School of Medicine, Columbia, SC (United States)] [and others

    1994-09-01

    Cytogenetic studies were initiated on a newborn female due to multiple congenital anomalies including microcephaly, clinodactyly, abnormal positioning of hands, left facial palsy, heart defect, sacral dimple, and facial dysmorphic features. Facial features were described as low set rotated ears, nystagmus, and a small, flattened nose. A structural rearrangement of the long arm of chromosome 3 was observed with a complex banding pattern. Study of parental chromosomes revealed a normal male pattern for the father, and an intrachromosomal insertion on the long arm of chromosome 3 for the mother described as 46,XX,dir ins(3)(q21q23q26.2). Further characterization of the proband`s structurally abnormal chromosome 3 revealed a karyotype best described as: 46,XX,rec(3),dupq23{r_arrow}q26.2::q21{r_arrow}q23,dir ins(3)(q21q23q26.2), which is a partial duplication of both the inserted segment as well as the intervening segment between the inserted segment and the insertion site. This would appear to be the result of a three-strand double cross-over within the insertion loop. Molecular cytogenetic studies are presently underway to further elucidate chromosome structure of the proband and her mother.

  8. Optical and near-IR spectroscopy of candidate red galaxies in two z~2.5 proto-clusters

    CERN Document Server

    Doherty, Michelle; De Breuck, Carlos; Ly, Chun; Kodama, Tadayuki; Kurk, Jaron; Seymour, Nick; Vernet, Joel; Stern, Daniel; Venemans, Bram; Kajisawa, Masaru; Tanaka, Ichi

    2009-01-01

    We present a spectroscopic campaign to follow-up red colour-selected candidate massive galaxies in two high redshift proto-clusters surrounding radio galaxies. We observed a total of 57 galaxies in the field of MRC0943-242 (z=2.93) and 33 in the field of PKS1138-262 (z=2.16) with a mix of optical and near-infrared multi-object spectroscopy. We confirm two red galaxies in the field of PKS1138-262 at the redshift of the radio galaxy. Based on an analysis of their spectral energy distributions, and their derived star formation rates from the H-alpha and 24um flux, one object belongs to the class of dust-obscured star-forming red galaxies, while the other is evolved with little ongoing star formation. This result represents the first red and mainly passively evolving galaxy to be confirmed as companion galaxies in a z>2 proto-cluster. Both red galaxies in PKS1138-262 are massive, of the order of 4-6x10^11 M_Sol. They lie along a Colour-Magnitude relation which implies that they formed the bulk of their stellar po...

  9. P70 S6 kinase mediates tau phosphorylation and synthesis

    DEFF Research Database (Denmark)

    Pei, Jin-Jing; An, Wen-Lin; Zhou, Xin-Wen;

    2006-01-01

    of total S6 and tau but not global proteins in SH-SY5Y cells. The requirement of p70S6K activation was confirmed in the SH-SY5Y cells that overexpress wild-type htau40. Level of p-p70S6K (T421/S424) was only significantly correlated with p-tau at S262, S214, and T212, but not T212/S214, in Alzheimer......Currently, we found that the 70-kDa p70 S6 kinase (p70S6K) directly phosphorylates tau at S262, S214, and T212 sites in vitro. By immunoprecipitation, p-p70S6K (T421/S424) showed a close association with p-tau (S262 and S396/404). Zinc-induced p70S6K activation could only upregulate translation......'s disease (AD) brains. These suggested that p70S6K might contribute to tau related pathologies in AD brains....

  10. Novel splice, missense, and nonsense mutations in the fumarylacetoacetase gene causing tyrosinemia type I

    Energy Technology Data Exchange (ETDEWEB)

    Rootwelt, H.; Kvittingen, E.A. [Univ. of Oslo (Norway); Berger, R. [Wilhelmina Kinderziekenhuis, Utrecht (Netherlands); Gray, G.; Kelly, D.A. [Children`s Hospital, Birmingham (United Kingdom); Coskun, T. [Hacettepe Univ., Ankara (Turkey)

    1994-10-01

    In six unrelated patients with hereditary tyrosinemia type 1 (HT1), three different disease-causing mutations were found by DNA sequencing. Two Pakistani patients, with acute and intermediate forms of HT1, were homozygous for a G{sup 192} {yields} T mutation in the last nucleotide of exon 2. This caused aberrant splicing with partial intron 2 retention and premature termination. Three Turkish patients with chronic and intermediate forms of HT1 were homozygous for an A{sup 698} {yields} T mutation substituting aspartic acid 233 with valine. A Norwegian patient with an intermediate clinical phenotype was heterozygous for G{sup 786} {yields} A, introducing a TGA stop codon for Trp262 (W262X). Site-directed mutagenesis and expression in a rabbit reticulocyte lysate system demonstrated that the nonsense and missense mutations abolished fumarylacetoacetase activity and gave reduced amounts of a truncated and a full-length protein, respectively. Simple tests were established to identify the three mutations by restriction digestion of PCR-amplified genomic DNA. Among 30 additional HT1 patients investigated, 2 were found to be homozygous and 1 heterozygous for G{sup 192} {yields} T. Two other patients were homozygous and one was heterozygous for W262X. 21 refs., 4 figs.

  11. Molecular Epidemiologic Study of VacA Genotypes of Helicobacter Pylori in Zhejiang Province%浙江省幽门螺杆菌cagA、vacA基因型的流行病学研究

    Institute of Scientific and Technical Information of China (English)

    林朗; 杨恩; 张红河; 杨宁敏

    2008-01-01

    目的 调查浙江地区幽门螺杆菌(helicobacter pylori,Hp)基因型的分布及其与临床疾病的关系.方法 采用特异引物聚合酶链反应(PCR)分析262株幽门螺杆菌的vacA基因多态性分布特点,并对其进行初步统计分析.结果 浙江8个地区分离培养的Hp菌株262株,VacA m1b基因型占27.10%(71/262);VacA m2基因型占64.89%(170/262);VacA m1b-m2基因型占4.20%(11/262);不同地区间VacA s区基因型和VacA m区基因型分布差异无统计学意义(P>0.05).慢性胃炎分离株中VacA m1b基因型占26.47%(27/102);VacA m2基因型占66.67%(68/102);VacA m1bm2基因型占2.94%(3/102).消化性溃疡分离株中VacA m1b基因型占29.41%(40/136);VacA m2基因型占61.76%(84/136);VacA m1bm2基因型占3.68%(5/136).胃癌分离株中VacA m1b基因型占16.67%(4/24);VacA m2基因型占75.00%(18/24);VacA m1bm2基因型占4.17%(1/24).不同临床疾病间VacA m区基因型分布差异无统计学意义(P>0.05).结论 浙江8个地区Hp菌株的优势基因型为cagA+、vacAs1/m2,vacA的s区和m区的分布与分布个体的临床类型无关.

  12. Effects of Nitrogen Application Rate on Yield and Nitrogen Utilization of Winter Wheat under Straw Returning Condition in Guanzhong Irrigation Area%关中灌区秸秆还田条件下施氮量对冬小麦产量及氮素利用的影响

    Institute of Scientific and Technical Information of China (English)

    沈海军; 祝飞华; 顾炽明; 郑险峰; 张向茹; 李有兵; 刘淼

    2012-01-01

    A field experiment with five treatments was conducted to study the nitrogen fertilization application rate of winter wheat in Guanzhong area under the straw returning condition, and winter wheat variety Xinong 979 served as material. The yield and the component factors of winter wheat, the nitrogen utilization rate, the contents of the nitrate nitrogen in the soil and the content of wheat protein under the different treatments were determined. With the amount of nitrogen fertilizer increasing, the grain yield of the wheat, biomass, 1 OOOgrain mass and the spike number per hectare climbed up and then declined. Grain yield, biomass and spike number per hectare reached its maximum under the treatment of N262.5, however, the maximum of 1 000-grain mass reached its maximum under the treatment of N175. Nitrogen recovery efficiency and nitrogen fertilizer use efficiency decreased along with the increase of the nitrogen application rate, while the nitrogen harvest index showed the tendency by increasing then declining and reached the largest under the treatment of N175. Compared to the N0 treatment, the accumulation of nitrate nitrogen in soil in the treatments N262.5 and N350 improved significantly after wheat harvest. The content of wheat protein increased significantly with the increasing of N applied in the range of 0 - 262. 5 kg/hm2. The optimum application rates of N fertilizer should be in the range of 175 - 262. 5 kg/hm2 considering the local technology level and the climate.%以西农979为供试材料,在秸秆还田条件下设置5个不同的冬小麦施氮水平进行田间试验,分析不同处理下冬小麦产量及产量构成因素、收获后土壤硝态氮以及冬小麦籽粒蛋白质含量.在秸秆还田条件下随施氮量的增加,冬小麦籽粒产量、生物学产量、有效穗数和千粒质量均呈先增后降趋势,籽粒产量、生物产量和公顷穗数在N262.5达到最大,千粒质量在N175达到最大.氮

  13. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices

    Institute of Scientific and Technical Information of China (English)

    Jiang FANG; Rong LIU; Qing TIAN; Xiao-ping HONG; Shao-hui WANG; Fu-yuan CAO; Xi-ping PAN; Jian-zhi WANG

    2007-01-01

    Aim:This study was to investigate the effect of dehydroevodiamine (DHED) on Alzheimer's disease (AD)-like tan hyperphosphorylation induced by calyculin A (CA),an inhibitor of protein phosphatase (PP)-2A and PP-1,and the involvement of PP-2A in metabolically competent rat brain slices. Methods:Rat brain slices were pre-incubated at 33 ℃ in the presence (10,100,and 200 μmol/L,respectively)or absence of DHED for 1 h. Then,CA 0.1 μmol/L was added and the slices were treated for another 2 h. Western blotting and/or immunohistochemistry were used to measure the phosphorylation level of tau and PP-2A. Results:CA treatment could remarkably increase the immunoreactivity of pS262 and decrease the staining of Tan-1,representing tau hyperphosphorylation at Ser262 (pS262) and Ser198/199/202 (Tau-1,as the antibody reacts with unphosphorylated tau,therefore,decreased staining represents increased phosphorylation). Pre-incubation of the brain slices with DHED could efficiently attenuate the CA-induced tan hyperphosphorylation at the above AD-related sites. Additionally,DHED also decreased the basal phosphorylation level of tan at Ser396,although CA failed to induce tan hyperphosphorylation at this site. Furthermore,CA treatment induced an increased level of Tyr307-phosphorylated PP-2A,which represents inactivation of the phosphatase,whereas DHED arrested the elevation of the inhibitory modification of PP-2A. Conclusion:DHED can attenuate CA-induced tau hyperphosphorylation at multiple AD-related sites in metabolically active rat brain slices. The underlying mechanism may involve a decreased inhibitory phosphorylation of PP-2A at Tyr307.AcknowledgementsWe thank Dr Khalid IQBAL,Dr Inge GRUNDKE-IQBAL,Dr Cheng-xin GONG,and Dr Fei LIU at New York State Institute for Basic Research for technical support.

  14. Role of secondary austenite on corrosion and stress corrosion cracking of sensitized duplex stainless steel weldments

    International Nuclear Information System (INIS)

    The role of secondary austenite on corrosion and stress corrosion cracking in high temperature water for sensitized duplex stainless steel weldment was investigated using transmission electron microscopy and fractography. Pitting potential measurements, 10% oxalic acid tests (ASTM A262A), Strauss tests (ASTM A262E) and Huey tests (ASTM A262C) were carried out for the corrosion assessment. For stress corrosion cracking, the slow strain rate testing (SSRT) was carried out at 562K with 8 ppm dissolved oxygen under 8 MPa at a strain rate of 4.17x10-6s-1. Volume fraction of γphase decreased with increasing peak temperature and the grain size of the γphase increased with increasing peak temperature. The amount of precipitation of Cr2N at the grain boundary and in the grain increased with increasing peak temperature. The region around Cr2N showed intergranular corrosion. For the sensitization at 923K for 72ks, σphase precipitated and secondary γphases (named γ* phase) appeared between primary γphase and σphase. The γ* phases were predominantly corroded and the pitting potentials were low. Stress corrosion cracking in high temperature water hardly occurred for the solution-treated specimen. The reduction in area of the specimen sensitized at 923K for 72ks was much lower than that of the solution-treated specimens and decreased with decreasing peak temperature, because the γ* phases near the M23C6 and σphase were predominantly corroded and dissolved. (author)

  15. Study on Alzheimer's disease model

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It is well known that the main brain lesion in Alzheimer's disease (AD) brain is neurofibrillary tangles (NFT) and senile plaques (SP). The amount of NFT is positively correlated with clinical degree of dementia in AD. It is also well studied that the major component of NFT is abnormally hyperphosphorylated microtubule associated protein tau that is caused by an imbalance of protein kinase and protein phosphatase (PP). To reconstitute a specific AD model based on the above hypothesis, we have injected separately calcium calmodulin dependent protein kinase (CaMKKII) activator, bradykinin and PP-2B inhibitor, cyclosporin A into rat hippocampus in the present study. The results showed that the injection of bradykinin caused learning and memory deficient in rats as well as Alzheimer-like tau phosphorylation, including Ser-262/356, Thr-231/235 and Ser-396/404. On the other hand, the injection of cyclosporin A induced the same phosphorylation sites as above except Ser-262/356, however, it did not mimic rat behavior abnormality as bradykinin injection did. The data suggested that activating of CaMKII and the phosphorylation of Ser-262/356 at tau might responsible for the lesion of learning and memory in our model rats. We also incubated PP-2A and PP-1 inhibitor, okadaic acid with human neuroblastoma cell line (SH-SY5Y), and found that (1) inhibition of above PPs induced Alzheimer-like phosphorylation and accumulation of neurofilaments, and Alzheimer-like microtubule disruption, (2) melatonin showed certain protection of the cell from okadaic acid toxicity. The data obtained from this study is significant in AD specific model study.

  16. Rearrangement reaction of the hydroxyl group of ω-hydroxy-alkyltriphenyl phosphonium bromides

    Institute of Scientific and Technical Information of China (English)

    何美玉; 袁谷; 贺晓然

    2000-01-01

    No molecular ion peak from the Electron Impact Ionization of eight ω-hydroxyalkyltriphenyl phosphonium bromides (Ph3P+ (CH2)nOHBr, n = 2-6, 8--10) can be found, except a part of some relative powerful fragment ions can be observed only. Each c ompound forms a very characteristic ion (O= PPh3- 1)+ atm/z 277throughhydryl rearrangement reaction. The intensity of this ion is closely related with the size of the carbon chain of hydroxyalkyl and with temperature of ion source and temperature of sample probe. The above rearrangement reaction and the reaction to form ion at m/ z 262 take place simultaneonsly, thus leading to strong competition.At n =2, ion at m/z 277 is the most powerful and becomes continuously the base peak. At n = 3 and n = 4, the intensity of ion at m/z 262 reaches the maximum, and is always the base peak, and the relative abundance of m/z 277 is only around 2%. At n = 5, 6, 8, 9, 10, m/z 277 becomes base peak when the temperature of probe is below 300°C. But, when the temperature increases from 300°C to 350°C, m/z 262 suddenly becomes the base peak, which is not in direct proportional relation with the size of carbon chain. It is proved by MIKES and accurate mass that ion at m/z 277 produces a fragment ion (O= PPh2-2)+ at m/z 199 with the loss of the neutral benzene molecule.

  17. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

    Science.gov (United States)

    Kong, Leopold; Torrents de la Peña, Alba; Deller, Marc C; Garces, Fernando; Sliepen, Kwinten; Hua, Yuanzi; Stanfield, Robyn L; Sanders, Rogier W; Wilson, Ian A

    2015-10-01

    The HIV-1 envelope gp160 glycoprotein (Env) is a trimer of gp120 and gp41 heterodimers that mediates cell entry and is the primary target of the humoral immune response. Broadly neutralizing antibodies (bNAbs) to HIV-1 have revealed multiple epitopes or sites of vulnerability, but mapping of most of these sites is incomplete owing to a paucity of structural information on the full epitope in the context of the Env trimer. Here, a crystal structure of the soluble BG505 SOSIP gp140 trimer at 4.6 Å resolution with the bNAbs 8ANC195 and PGT128 reveals additional interactions in comparison to previous antibody-gp120 structures. For 8ANC195, in addition to previously documented interactions with gp120, a substantial interface with gp41 is now elucidated that includes extensive interactions with the N637 glycan. Surprisingly, removal of the N637 glycan did not impact 8ANC195 affinity, suggesting that the antibody has evolved to accommodate this glycan without loss of binding energy. PGT128 indirectly affects the N262 glycan by a domino effect, in which PGT128 binds to the N301 glycan, which in turn interacts with and repositions the N262 glycan, thereby illustrating the important role of neighboring glycans on epitope conformation and stability. Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding. These complete epitopes of two broadly neutralizing antibodies on the Env trimer can now be exploited for HIV-1 vaccine design. PMID:26457433

  18. Post-Closure Inspection Letter Report for Corrective Action Units on the Nevada National Security Site

    Energy Technology Data Exchange (ETDEWEB)

    Boehleke, R. F.

    2014-05-06

    This letter serves as the post-closure inspection letter report for Corrective Action Units (CAUs) on the Nevada National Security Site for calendar year 2013. The inspections identified maintenance and repair is required at the following sites: sign and/or fence repair is necessary at CAUs 113, 137, 139, 140, 143, 262, 370, 371, 372, 374, 476, 478, 529, 542, and 560; animal burrows were identified at CAU 547; and erosion was identified at CAUs 366, 367, 383, 551, and 574. In addition, the following use restrictions were removed during 2013 and will no longer be inspected in 2014: 165, 357, and 528.

  19. Estudio de la flora de comunidades ruderales antropogénicas en la IX Región de la Araucanía, Chile

    OpenAIRE

    Ramírez García, Carlos; San Martín Padovani, Cristina; Ojeda, Pedro

    1999-01-01

    Se estudió la flora ruderal de cuatro formaciones vegetales antropogénicas (matorrales de Pica-Pica, praderas, lagunas y arroyos con vegetación palustre y acuática) en la zona ubicada al poniente de la ciudad de Temuco (IX Región de la Araucanía, Chile). La lista de especies presentes se obtuvo de la primera columna de una tabla de vegetación formada por 403 censos, que fueron levantados con la metodología fitosociológica del Sur de Europa. Se encontró un total de 262 especies vegetales, con ...

  20. Measurement of nutritional status in oncological patients by mini nutritional assessment%微型营养评定法在恶性肿瘤病人中的应用

    Institute of Scientific and Technical Information of China (English)

    朱步东; 赵启成; 黄晓蕾; 刘淑俊; 张联

    2002-01-01

    为探讨微型营养评定法(MNA)在恶性肿瘤病人的营养状况评价中的价值,测定262例恶性肿瘤病人的MNA总分、身高、体重、年龄、体力状况、血液血红蛋白量(Hb)、红细胞数(RBC)、血清白蛋白浓度(Alb)、血清前白蛋白浓度(PA).计算实际体重/健康时平时体重比(UBW%).根据MNA总分评价病人营养状况:营养不良组(MNA总分<17);营养不良危险组(MNA总分介于17~23.5);营养良好组(MNA总分≥24).结果显示:MNA总分与UBW%、Alb、PA、BMI值呈显著相关(r=0.501~0.724,P=0.000).MNA与UBW%、BMI、PA、Alb方法评价病人的营养状况有良好的一致性,符合率分别为82%、76%、71%、68%.根据MNA方法评价全组病人,营养不良者占31.7%(83/262例),营养不良危险者占25.9%(68/262例),营养良好者占42.4%(111/262例);营养不良与营养不良危险的发生率无显著性差异;老年与非老年患者营养不良发生率无明显差异.胃癌、肝癌的营养不良发生率明显高于肺癌(P=0.001).体力状况越差(ECOG分级越高)、营养不良发生率越高.贫血患者营养不良发生率明显高于非贫血者.感染患者营养不良发生率明显高于非感染者.结果提示,MNA对于恶性肿瘤患者具有良好的营养评价作用.胃癌和肝癌患者的营养不良发生率较高.

  1. Using GeoGebra as an Expressive Modeling Tool: Discovering theAnatomy of the Cycloid’s Parametric Equation

    OpenAIRE

    Muharrem Aktumen; Tolga Kabaka

    2010-01-01

    In Greek geometry, curves were defined as objects, which are geometric and static. For example, a parabola is defined as the intersection of a cone and plane like other conics, which are first introduced by Apollonius of Perga (262 BC – 190 BC). Alternatively, 17th century European mathematicians have preferred to define the curves as the trajectory of a moving point. In his Dialogue Concerning Two New Science of 1638, Galileo found the trajectory of a canon ball. Assuming a vacuum, the traje...

  2. Basic research for nuclear energy. y Study on the nuclear materials technology

    Energy Technology Data Exchange (ETDEWEB)

    Kuk, I. H.; Lee, H. S.; Jeong, Y. H.; Sung, K. W.; Han, J. H.; Lee, J. T.; Lee, H. K.; Kim, S. J.; Kang, H. S.; An, D. H.; Kim, K. R.; Park, S. D.; Han, C. H.; Jung, M. K.; Oh, Y. J.; Kim, K. H.; Kim, S. H.; Back, J. H.; Kim, C. H.; Lim, K. S.; Kim, Y. Y.; Na, J. W.; Ku, J. H.; Lee, D. H.

    1996-12-01

    A study on the nuclear materials technologies which are necessary to establish the base for alloy development was performed. - The feasibility study on the application of Zircaloy scrap waste for hydrogen storage - The development of metal hydride battery for energy storage system - The establishment of transmission electron microscopy database for nuclear materials - The basic technology for the development of cladding materials for high burnup - The water chemistry technology for secondary system pH control and the photocatalysis technology for decomposition and removal of organics. - Improvement of primary component integrity of PWR by Zinc injection. (author). 175 refs., 58 tabs., 262 figs.

  3. Basic research for nuclear energy. y Study on the nuclear materials technology

    International Nuclear Information System (INIS)

    A study on the nuclear materials technologies which are necessary to establish the base for alloy development was performed. - The feasibility study on the application of Zircaloy scrap waste for hydrogen storage - The development of metal hydride battery for energy storage system - The establishment of transmission electron microscopy database for nuclear materials - The basic technology for the development of cladding materials for high burnup - The water chemistry technology for secondary system pH control and the photocatalysis technology for decomposition and removal of organics. - Improvement of primary component integrity of PWR by Zinc injection. (author). 175 refs., 58 tabs., 262 figs

  4. La inútil añoranza de la normalidad

    Directory of Open Access Journals (Sweden)

    Margarita Valencia

    2014-02-01

    Full Text Available Litchis de Madagascar. Aquiles Cuervo. Editorial Elfin de la noche. Buenos Aires, 2011, 91 págs. El ruido de las cosas al caer. Juan Gabriel Vásquez. Premio Alfaguara de novela 2011. Alfaguara. Bogotá. 2011, 259 págs. Tres ataúdes blancos. Antonio Ungar. Premio Herralde de Novela. Editorial Anagrama. Barcelona. 2010, 259 págs. Suicídame. Andrés Arias. Ediciones B. Bogotá, 2010, 261 págs. C.M. no récord. Juan Álvarez. Alfaguara. Bogotá, 2010, 262 págs.

  5. Avaliação da Sobrevivência e do Desenvolvimento Psicomotor em Ex-Recém- Nascidos de Muito Baixo Peso com Idade Igual ou Superior a 3 Anos (Evolução ao Longo de Onze Anos)

    OpenAIRE

    Simões, A. P.; Nunes, A.; Melo, e, F.S.; Paz, I.; Santos, C.; Bispo, M.A.; Palminha, J.M.

    2014-01-01

    Objectivos: Estudo da sobrevivência do Recém Nascido de Muito Baixo Peso (RNMBP) ao longo de 11 anos (1987 a 1997) e avaliação do desenvolvimento psicomotor das crianças com idade igual ou superior a três anos de idade, nascidas em dois períodos diferentes, com práticas diferentes no seu cuidar.Metodologia: Determinou-se a taxa de sobrevivência de 262 e 159 RNMBP nascidos, respectivamente, entre 1987-1993 (período A) e 1994 -1997 (período B). Avaliou-se o desenvolvimento psicomotor de 67 cria...

  6. Application of patent BR102013018500-0 in well type ionization chambers

    International Nuclear Information System (INIS)

    The definition of the radioactive sample position in a well type ionization chamber is the largest source of uncertainty in the measurement of quantity activity. The determination of this parameter in two activimeter helped to improve their accuracies, from 2.62 and 2.59% to 3.87 and 1.74%, with and without the use of the positioning device, concluding, that with their use has reached an uncertainty of U = 0.2276 and 0.2677 % (k = 2) 95.45%. (author)

  7. Renewable energy projects in the Dominican Republic

    Energy Technology Data Exchange (ETDEWEB)

    Viani, B.

    1997-12-01

    This paper describes a US/Dominican Republic program to develop renewable energy projects in the country. The objective is to demonstrate the commercial viability of renewable energy generation projects, primarily small-scale wind and hydropower. Preliminary studies are completed for three micro-hydro projects with a total capacity of 262 kWe, and two small wind power projects for water pumping. In addition wind resource assessment is ongoing, and professional training and technical assistance to potential investors is ongoing. Projects goals include not less than ten small firms actively involved in installation of such systems by September 1998.

  8. Complete Genome Sequences of Lytic Bacteriophages of Xanthomonas arboricola pv. juglandis.

    Science.gov (United States)

    Retamales, Julio; Vasquez, Ignacio; Santos, Leonardo; Segovia, Cristopher; Ayala, Manuel; Alvarado, Romina; Nuñez, Pablo; Santander, Javier

    2016-06-02

    Three bacteriophages, f20-Xaj, f29-Xaj, and f30-Xaj, with lytic activity against Xanthomonas arboricola pv. juglandis were isolated from walnut trees (VIII Bío Bío Region, Chile). These lytic bacteriophages have double-stranded DNA (dsDNA) genomes of 43,851 bp, 41,865 bp, and 44,262 bp, respectively. These are the first described bacteriophages with lytic activity against X. arboricola pv. juglandis that can be utilized as biocontrol agents.

  9. Posttraumatic Stress Disorder After Bereavement: Early Psychological Sequelae of Losing a Close Relative Due to Terminal Cancer

    DEFF Research Database (Denmark)

    Kristensen, T. E.; Elklit, A.; Karstoft, K. I.

    2012-01-01

    Very few studies have investigated posttraumatic stress disorder (PTSD) as a consequence of bereavement from terminal illness. Therefore, knowledge on the traumatizing effects of bereavement and risk factors for traumatization from bereavement is rather sparse. This study investigated prevalence...... clinical PTSD and an additional 26.2% reached a subclinical PTSD level. Negative affectivity, social support, and locus of control in relation to the loss predicted 57% of the variance in PTSD severity. A focus on these risk factors in early assessment after bereavement will help identify subjects at risk...... for developing PTSD as a result of bereavement....

  10. A nuclear juvenile hormone-binding protein from larvae of Manduca sexta: a putative receptor for the metamorphic action of juvenile hormone.

    OpenAIRE

    Palli, S R; Touhara, K; Charles, J.P; Bonning, B.C.; Atkinson, J K; Trowell, S C; Hiruma, K.; Goodman, W G; Kyriakides, T; Prestwich, G. D.

    1994-01-01

    A 29-kDa nuclear juvenile hormone (JH)-binding protein from the epidermis of Manduca sexta larvae was purified by using the photoaffinity analog for JH II ([3H]epoxyhomofarnesyldiazoacetate) and partially sequenced. A 1.1-kb cDNA was isolated by using degenerate oligonucleotide primers for PCR based on these sequences. The cDNA encoded a 262-amino acid protein that showed no similarity with other known proteins, except for short stretches of the interphotoreceptor retinoid-binding protein, rh...

  11. Psychometric properties of the Brand Personality Scale: evidence from a business school.

    Science.gov (United States)

    Caruana, Albert; Pitt, Leyland F; Berthon, Pierre; Berthon, J-P

    2007-06-01

    The Brand Personality Scale has received considerable attention and has been frequently used and cited in the branding literature. This paper describes an investigation of the psychometric characteristics of the Brand Personality Scale in a business school context where umbrella branding is used. A sample (N=262) of students attending the MBA program of a major business school in eastern USA completed the scale. Results indicate problems with the scale's dimensionality, poor reliability, convergent and nomological validity of the Ruggedness dimension, and lack of support for discriminant validity. Managerial and research implications and limitations are noted.

  12. 某含钽铌花岗岩成岩成矿温度的研究

    Institute of Scientific and Technical Information of China (English)

    卢焕章

    1975-01-01

    Formation temperatures are obtained for a tantalum-niobium-bearing granite(512-530℃),the feldspar-quartz zone(495℃),the quartz zone(483℃)in the pegmatoid and wolframite-quartz vein(262-273℃,no pressure corection has been made through studies of fluid inclusions in quartz,wolframite,Mn-rich columbite microlite and other minerals,The results demonstrate that petrogenesis and metallogenesis of this district are a protracted,multistage process.

  13. Analysis of dominant lactic acid bacteria from artisanal raw milk cheeses produced on the mountain Stara Planina, Serbia

    Directory of Open Access Journals (Sweden)

    Begovic Jelena

    2011-01-01

    Full Text Available Traditional Serbian cheese production has a long history and generates products with rich flavor profiles. To enable the industrial manufacture of these home-made Serbian cheeses, the lactic acid bacteria present in them needs to be characterized. Five fresh white cheeses made from raw cow’s milk without commercial starter cultures were collected from households on the mountain Stara Planina, Serbia. According to phenotypical and molecular analysis, 262 isolated Lwere found to belong to Lactococcus, Lactobacillus, Streptococcus, Leuconostoc or Enterococcus. The unique bacterial composition of each cheese indicates that the preservation of household industry is the way to maintain production of distinct cheeses.

  14. Estimation of effective dose in patients from barite examinations of the digestive system in Malaga (Spain)

    International Nuclear Information System (INIS)

    The purpose of this research is to present dose reference values of patients in complex explorations. A plane ionization camera was used to obtain the values of the dose-area product (Gy/Square cm). By means of the method described in the NRPB R-262 report, the effective dose values have been determined for each projection used (mSV). The product values of the dose-area and effective dose have been obtained for oesophagogrammes; for oesophago-gastro-duodenal studies; for intestinal transitions; for enteroclisis and for opaque enemas

  15. Expression in Saccharomyces cerevisiae of human interferon-alpha directed by the TRP1 5' region.

    OpenAIRE

    Dobson, M J; Tuite, M F; Mellor, J; Roberts, N A; King, R M; Burke, D. C.; Kingsman, A J; Kingsman, S M

    1983-01-01

    The complete 5' flanking region of the yeast TRP1 gene encoding N-(5'-phosphoribosyl)- anthranilate isomerase, a nonabundant protein, has been cloned and the nucleotide sequence data has been extended from -102 to -440. The CT block--CAAG structure common to all efficiently expressed yeast genes is altered in the 5' region of TRP1 and a sequence postulated to be involved in general amino acid regulation is absent. There are two possible TATA boxes at -224 and -262. TRP1, in common with HIS3, ...

  16. G.Th.A. Calkoen, Onder studenten. Leidse aanstaande medici en de metamorfose van de geneeskunde in de negentiende eeuw (1838-1888; G.Th.A. Calkoen, Hector Treub (1856-1920; H.J. Klasen, De chirurgische wondbehandeling in het pre-Lister tijdperk

    Directory of Open Access Journals (Sweden)

    Stephan Snelders

    2014-05-01

    Full Text Available G.Th.A. Calkoen, Onder studenten. Leidse aanstaande medici en de metamorfose van de geneeskunde in de negentiende eeuw (1838-1888 (Dissertatie Leiden 2012; Leiden: Ginkgo, 2012, 732 pp., ISBN 978 90 71256 20 2; G.Th.A. Calkoen, Hector Treub (1856-1920 (Leiden: Ginkgo, 2013, 36 pp., ISBN 978 90 71256 23 3; H.J. Klasen, De chirurgische wondbehandeling in het pre-Lister tijdperk (1750-1850 (Rotterdam: Erasmus Publishing, 2013, 262 pp., ISBN 978 90 5235 216 9

  17. Ganymede's Shadow

    Science.gov (United States)

    2007-01-01

    The New Horizons Long Range Reconnaissance Imager (LORRI) took this photo of Jupiter at 20:42:01 UTC on January 9, 2007, when the spacecraft was 80 million kilometers (49.6 million miles) from the giant planet. The volcanic moon Io is to the left of the planet; the shadow of the icy moon Ganymede moves across Jupiter's northern hemisphere. Ganymede's average orbit distance from Jupiter is about 1 million kilometers (620,000 miles); Io's is 422,000 kilometers (262,000 miles). Both Io and Ganymede are larger than Earth's moon; Ganymede is larger than the planet Mercury.

  18. The impact of socioeconomic status across early life on age at menarche among a racially diverse population of girls

    OpenAIRE

    James-Todd, Tamarra; Tehranifar, Parisa; Rich-Edwards, Janet Wilson; Titievsky, Lina; Terry, Mary Beth

    2010-01-01

    Purpose We sought to evaluate the association between childhood socioeconomic status (SES) at two time points and age at menarche in a multiracial sample of U.S. girls. Methods Our study population consisted of a cohort of female participants enrolled at birth at the New York site of the Collaborative Perinatal Project, who were born during the period 1959–1963 (n = 262). SES at birth, at age 7, and change between birth and age 7 were measured prospectively through an index score ...

  19. Dicty_cDB: Contig-U12270-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available quences producing significant alignments: (bits) Value N ( C90879 ) Dictyostelium discoideum slug cDNA, clon...e SSJ262. 226 2e-82 5 ( AU038542 ) Dictyostelium discoideum slug cDNA, clone SSH848. 242 3e-79 3 ( C93805 ) ...Dictyostelium discoideum slug cDNA, clone SSL738. 242 3e-79 3 ( AU038033 ) Dictyostelium discoideum slug cDN...A, clone SSH182. 244 5e-77 3 ( C92024 ) Dictyostelium discoideum slug cDNA, clone... SSC175. 242 9e-77 3 ( C89806 ) Dictyostelium discoideum slug cDNA, clone SSG177. 226 1e-75 4 ( AU037712 ) D

  20. Application of patent BR102013018500-0 in well type ionization chambers

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, C.H.S.; Peixoto, J.G.P., E-mail: chenriques2@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The definition of the radioactive sample position in a well type ionization chamber is the largest source of uncertainty in the measurement of quantity activity. The determination of this parameter in two activimeter helped to improve their accuracies, from 2.62 and 2.59% to 3.87 and 1.74%, with and without the use of the positioning device, concluding, that with their use has reached an uncertainty of U = 0.2276 and 0.2677 % (k = 2) 95.45%. (author)

  1. Effects of sulphur dioxide on southern bean mosaic and maize dwarf mosaic

    Energy Technology Data Exchange (ETDEWEB)

    Laurence, J.A.; Aluisio, A.L.; Weinstein, L.H.; McCune, D.C.

    1981-01-01

    Sub-acute doses of sulphur dioxide (SO/sub 2/) (either 262 or 524 ..mu..g m/sup -3/) for 5-10 days caused small but consistent increases in the titre of southern bean mosaic virus (SBMV) in Bountiful bean and maize dwarf mosaic virus (MDMV) in maize. Exposure to SO/sub 2/ also increased infection and intensified symptoms caused by MDMV. Sulphur uptake by the host plant was not affected by either virus; however, pre- and post-inoculation exposures of bean plants to SO/sub 2/ resulted in greater than additive effects on sulphur uptake.

  2. Estudo das freqüências dos principais fatores de risco para acidente vascular cerebral isquêmico em idosos Study of the main risk factors frequencies for ischemic cerebrovascular disease in elderly patients

    OpenAIRE

    Sueli Luciano Pires; Rubens José Gagliardi; Milton Luiz Gorzoni

    2004-01-01

    Foram estudados retrospectivamente 262 pacientes com diagnóstico clínico de acidente vascular cerebral isquêmico (AVCi) permanente, com idade igual ou superior a 60 anos, selecionados dos 1015 registros da Liga de Aterosclerose da Clínica Neurológica da ISCMSP, de 1990 a 2002. O estudo focalizou as freqüências dos fatores de risco modificáveis para AVCi nesta população idosa, considerando-se sexo e faixa etária dos pacientes. Os resultados evidenciaram que a hipertenção arterial sistêmica é s...

  3. Determining the impact of low-cost housing development on nearby property prices using discrete choice analysis

    OpenAIRE

    du Preez, M; M.C. Sale

    2012-01-01

    This paper presents an application of the conditional logit model to a small, Nelson Mandela Bay neighbourhood housing data set, with the objective of determining the impact of proximity to a low-cost housing development on nearby property prices. The results of this pilot study show that the average household in the neighbourhood of Walmer is willing to pay between R27 262 and R195 564 to be located 86m further away from an existing low—cost housing development. In addition to this, the pr...

  4. A simple calibration of a whole-body counter for the measurement of total body potassium in humans

    International Nuclear Information System (INIS)

    A simple calibration procedure for the Inshas whole body counter for evaluating total body potassium has been adopted. More than 120 Egyptian employees in the Nuclear Research Center (N.R.C.) were studied for their total body potassium (TBK). The potassium values were found to have an average of 2.85±0.57 g K kg-1 body weight for males and 2.62±0.52 g K kg-1 for females, which are higher than the recommended value given for reference man by ICRP. The TBK varied directly with body build index and is slightly sex dependent (Author)

  5. Potassium body burdens in occupational users of egyptian nuclear research center

    International Nuclear Information System (INIS)

    A simple calibration procedure for inshas whole body counter for evaluating total potassium have been adopted. More than 120 egyptian employee in the nuclear research center (N. R. C.) were studied for their total body potassium (TBK). The potassium values were found to have an average of 2.85 gm k kg-1 body weight for males and 2.62 gm k kg-1 for females, which is higher than the recommended value given for reference man by ICRP. The TBK varied directly with body build index and is slightly dependent.7 figs., 1 tab

  6. Noncyclic geometric phase for neutrino oscillation

    CERN Document Server

    Wang, X B; Liu, Y; Oh, C H; Wang, Xiang-Bin; Liu, Yong

    2001-01-01

    We provide explicit formulae for the noncyclic geometric phases or Pancharatnam phases of neutrino oscillations. Since Pancharatnam phase is a generalization of the Berry phase, our results generalize the previous findings for Berry phase in a recent paper [Phys. Lett. B, 466 (1999) 262]. Unlike the Berry phase, the noncyclic geometric phase offers distinctive advantage in terms of measurement and prediction. In particular, for three-flavor mixing, our explicit formula offers an alternative means of determining the CP-violating phase. Our results can also be extended easily to explore geometric phase associated with neutron-antineutron oscillations.

  7. Chronic complaints after simple sutured repair for umbilical or epigastric hernias may be related to recurrence

    DEFF Research Database (Denmark)

    Westen, Mikkel; Christoffersen, Mette W; Jorgensen, Lars N;

    2014-01-01

    hernias. METHODS: A retrospective cohort study with a 5-year questionnaire and clinical follow-up was conducted. Patients undergoing primary elective, open non-mesh umbilical or epigastric sutured hernia repair were included. Patients completed a structured questionnaire regarding chronic complaints...... during work and leisure activities using a verbal rating scale. The primary outcome was chronic complaints. RESULTS: A total of 295 patients were included for analysis after a median of 5.0-year (range 2.8-8.0) follow-up period. Follow-up results were achieved from 262 of the included patients (90...

  8. Long-term results of Danish Prostatic Cancer Group trial 86. Goserelin acetate plus flutamide versus orchiectomy in advanced prostate cancer

    DEFF Research Database (Denmark)

    Iversen, P; Rasmussen, F; Klarskov, Peter;

    1993-01-01

    In a multicenter trial conducted by the Danish Prostatic Cancer Group, 264 patients with advanced prostate cancer were randomized either to undergo bilateral orchiectomy or to receive combination treatment with goserelin acetate and flutamide. This report is an update of that study, covering...... of goserelin and flutamide was not clinically superior to bilateral orchiectomy in the treatment of advanced prostate cancer....... a median follow-up for survival of 57 months. Of 262 patients who were evaluated, 208 have died. As noted in earlier analyses of this study, no differences in time to progression and cause-specific and overall survival could be identified between the two treatment groups. In conclusion, the combination...

  9. AcEST: BP921778 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000154_A09 262 Adiantum capillus-veneris mRNA. clone: YMU001_000154_A09. BP921778 - Show BP92177...is mRNA. clone: YMU001_000154_A09. Accession BP921778 Tissue type prothallium Developmental stage - Contig I...BLAST: a new generation of protein database search programs, Nucleic Acids Res. 25:3389-3402. Query= BP92177...s, Nucleic Acids Res. 25:3389-3402. Query= BP921778|Adiantum capillus-veneris mRNA, clone: YMU001_000154_A09

  10. Hemoglobin affinity and structure in high-altitude and sea-level carnivores from Peru.

    Science.gov (United States)

    León-Velarde, F; de Muizon, C; Palacios, J A; Clark, D; Monge, C

    1996-04-01

    We compared hemoglobin affinity (P50) and structure of high altitude (HA) carnivores with populations of the same species or genus living at sea level (SL). P50 was measured in cats, pumas and foxes. It differed in animals occupying both niches. SL: cat 29.3 torr, puma 36.3 torr, fox 26.2 torr; HA: cat 22.5 torr, puma 31.1 torr, fox 18.5 torr. Heme and globins were fractionated by HPLC. Puma and fox hemoglobins also showed structural differences. P50 is lower in genotypically HA-adapted species studied and can differentiate SL and HA populations of the same species.

  11. Application of patent BR102013018500-0 in well type ionization chambers

    Science.gov (United States)

    Sousa, C. H. S.; Peixoto, J. G. P.

    2016-07-01

    The definition of the radioactive sample position in a well type ionization chamber is the largest source of uncertainty in the measurement of quantity activity. The determination of this parameter in two activimeters helped to improve their accuracies, from 2.62 and 2.59% to 3.87 and 1.74%, with and without the use of the positioning device, concluding, that with their use has reached an uncertainty of U =2276 and 0.2677% (k = 2) 95.45%.

  12. Radioimmunoassay of serum β2-microglobulin in donor's blood

    International Nuclear Information System (INIS)

    Serum β2-microglobulin (β2-MG) was tested by radioimmunoassay in 149 donors' and 54 healthy volunteers' blood. The results were 203 +- 33.0 nmol/l and 176 +- 26.2 nmol/l, respectively. There was significant difference statistically between them (P2-MG content. In order to increase the quality of donated blood and to keep the health of blood donor, it is suggested that the high content of serum β2-MG is the indicator of too frequent blood donating. The results also showed that the content of β2-MG in donor's blood is not a normal reference value

  13. EST Table: BY931919 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY931919 E_EL_ovS0_27A11_R_0 11/12/09 n.h 10/09/28 38 %/260 aa ref|XP_001123029.1| ...ifera] 10/08/29 40 %/260 aa FBpp0168843|DmojGI19626-PA 10/08/28 low homology 10/09/10 34 %/262 aa AGAP009046...-PA Protein|3R:24679530:24681041:1|gene:AGAP009046 10/09/10 38 %/260 aa gnl|Amel|GB19...sociated protein 18 homolog (WD repeat protein l(2)k07824) [Tribolium castaneum] BY931919 ovS0 ...

  14. Avoidant coping and PTSD symptoms related to domestic violence exposure: a longitudinal study.

    Science.gov (United States)

    Krause, Elizabeth D; Kaltman, Stacey; Goodman, Lisa A; Dutton, Mary Ann

    2008-02-01

    The impact of avoidant coping on level of PTSD symptoms over 1 year was examined among 262 women exposed to intimate partner violence (IPV) within the past month. Covariates included childhood sexual abuse (CSA), IPV severity, perceived and formal social support, and revictimization. Using longitudinal hierarchical multiple regression, avoidant coping was found associated with PTSD symptoms at 1-year follow-up, controlling for initial symptoms and covariates. Revictimization also had long-term consequences beyond Time 1 symptoms. Reducing avoidant coping and increasing survivors' safety may assist in breaking a cycle of problematic coping and psychological distress. PMID:18302182

  15. Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum.

    OpenAIRE

    Inselburg, J; Bzik, D J; Li, W B; Green, K M; Kansopon, J; Hahm, B K; Bathurst, I C; Barr, P J; Rossan, R N

    1991-01-01

    We describe the vaccination of Panamanian monkeys (Aotus sp.) with two recombinant blood stage antigens that each contain a portion of the N-terminal region of the SERA (serine repeat antigen) protein of the malaria parasite Plasmodium falciparum. We immunized with either a 262-amino-acid SERA fragment (SERA I) that contains amino acids 24 to 285 of the 989-amino-acid protein or a 483-amino-acid SERA fragment (SERA N) that contains amino acids 24 to 506 as part of a fusion protein with human ...

  16. Valorization of raspberry seed cake by flash and slow pyrolysis: Product yield and characterization of the liquid and solid fraction

    OpenAIRE

    Smets, Koen; Schreurs, Sonja; Carleer, Robert; Yperman, Jan

    2014-01-01

    The valorization of raspberry seed cake by flash and slow pyrolysis is investigated in this study. During flash pyrolysis, temperature significantly affects the yield and properties of the products. The highest liquid yield (53.6 wt%) is found at 450 degrees C. This liquid has a water content (26.2 wt%), a HHV (18.6 MJ/kg) and a pH-value (3.2) that are comparable to those of pyrolysis liquids produced by flash pyrolysis of lignocellulosic biomass. In terms of added-value chemicals, levoglucos...

  17. Dengue Specific Immunoglobulin A Antibody is Present in Urine and Associated with Disease Severity

    OpenAIRE

    Hui Zhao; Shuang Qiu; Wen-Xin Hong; Ke-Yu Song; Jian Wang; Hui-Qin Yang; Yong-Qiang Deng; Shun-Ya Zhu; Fu-Chun Zhang; Cheng-Feng Qin

    2016-01-01

    The kinetics of dengue virus (DENV)-specific IgA antibody in urine and the potential correlation with disease severity remain elusive. In this study, 262 serial urine samples from 78 laboratory-confirmed patients were assayed by a commercial immunoglobulin A (IgA) kit against DENV. All cases were classified into dengue fever (DF) and severe dengue (SD) according to the 2009 WHO/TDR guideline. The total positive rate of IgA in urine was 59%. DENV-specific IgA was detected in urine from day 2 t...

  18. Results of Hg speciation testing on tank 39 and 1Q16 tank 50 samples

    Energy Technology Data Exchange (ETDEWEB)

    Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-03-07

    The Savannah River National Laboratory (SRNL) was tasked with preparing and shipping samples for Hg speciation by Eurofins Frontier Global Sciences, Inc. in Seattle, WA on behalf of the Savannah River Remediation (SRR) Mercury Task Team.i,ii The seventeenth shipment of samples was designated to include two Tank 39 samples and the 1Q16 Tank 50 Quarterly WAC sample. The surface Tank 39 sample was pulled at 262.1” from the tank bottom, and the depth Tank 39 sample was pulled at 95” from the tank bottom. The 1Q16 Tank 50 WAC sample was drawn from the 1-L variable depth sample received by SRNL.

  19. Electron probe analysis, X-ray mapping, and electron energy-loss spectroscopy of calcium, magnesium, and monovalent ions in log-phase and in dividing Escherichia coli B cells.

    OpenAIRE

    Chang, C. F.; Shuman, H; Somlyo, A P

    1986-01-01

    The elemental composition of individual cells of rapidly frozen and cryosectioned Escherichia coli B was measured with electron optical microanalytic methods. The Ca content was high (26.2 mmol/kg) in a 10-nm-wide region of the cell envelope. Amounts of cytoplasmic Ca in actively dividing cells were significantly higher (32.6 mmol/kg [dry weight]) than in the log-phase (1.5 mmol/kg) cells. Cellular Mg was 205 mmol/kg (dry weight) and it was uniformly distributed throughout the cell. Cells was...

  20. Etudes de l'oxydation de phénol et crésols par l'oxydation électrochimique avancée en milieu homogène. Application au traitement d'effluent de l'industrie aéronautique

    OpenAIRE

    Pimentel, Marcio

    2008-01-01

    Oxidation of phenol and cresols in aqueous media by electro-Fenton process using carbon felt cathode has been studied. The absolute rate constant of phenol and o-cresol degradation by hydroxyl radicals were obtained in acid medium (2.5 < pH < 3.0), being respectively equal to (2.62  0.23) x 109 M-1 s-1 and (3.70  0.19) x 109 M-1 s-1. The salts of iron, cobalt, manganese and copper were used to provide the metal cations as catalyst of Fenton reaction to produce hydroxyl radicals. 10-4 M of s...

  1. Book Reviews

    OpenAIRE

    Redactie KITLV

    1982-01-01

    -Hoffmann Léon-Francois, J. Michael Dash, Literature and ideology in Haiti 1915-1961. London and Basingstoke: The MacMillan Press, 1981. xv + 213 pp. -Gabriel Debien, Sidney W. mINTZ, Esclave = facteur de production: l'économie politique de l'esclavage. Paris: Dunod, 1981. xvii + 271 pp. -Franklin W. Knight, Bridget Brereton, A history of modern Trinidad, 1783-1962. Kingston, Port-of-Spain, London: Heinemann Educational Books Ltd., 1981. x + 262 pp. -Donald J. Waters, Walter Rodney, A history...

  2. Disease: H00887 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00887 Lipoprotein glomerulopathy Lipoprotein glomerulopathy is a rare hereditary d...490634 (description, gene) Sam R, Wu H, Yue L, Mazzone T, Schwartz MM, Arruda JA, Dunea G, Singh AK Lipoprotein glomerulo...-48 (2006) PMID:16431249 (description, gene) Saito T, Matsunaga A, Oikawa S Impact of lipoprotein glomerul...V, Elisaf M Lipoprotein glomerulopathy. Curr Opin Lipidol 22:262-9 (2011) PMID:16...isease APOE [HSA:348] [KO:K04524] MeSH: C567089 OMIM: 611771 PMID:21464714 (description, gene) Tsimihodimos

  3. Influence of Temperature and Time on Nutrient Release Patterns of Osmocote Plusâ ¢, Nutricoteâ ¢, and Polyonâ ¢ Controlled-Release Fertilizers

    OpenAIRE

    Husby, Chad Eric

    2000-01-01

    Polymer-coated controlled-release fertilizers (PCFs) are the most widely used class of fertilizers in the production of container-grown nursery plants. Nutrient release from PCFs is primarily influenced by temperature. The objective of this study was to determine the influences of temperature and time on the nutrient release patterns of three PCFs (each with a rated longevity of 8-9 months), each using a different coating technology: Osmocote Plusâ ¢ 15N-3.93P-9.96K, Polyonâ ¢ 18N-2.62P-9....

  4. High-Precision Measurement of the 19Ne Half-Life and Implications for Right-Handed Weak Currents

    CERN Document Server

    Triambak, S; Sumithrarachchi, C S; Hackman, G; Ball, G C; Garrett, P E; Svensson, C E; Cross, D S; Garnsworthy, A B; Kshetri, R; Orce, J N; Pearson, M R; Tardiff, E R; Al-Falou, H; Austin, R A E; Churchman, R; Djongolov, M K; D'Entremont, R; Kierans, C; Milovanovic, L; O'Hagan, S; Reeve, S; Sjue, S K L; Williams, S J

    2012-01-01

    We report a precise determination of the 19Ne half-life to be $T_{1/2} = 17.262 \\pm 0.007$ s. This result disagrees with the most recent precision measurements and is important for placing bounds on predicted right-handed interactions that are absent in the current Standard Model. We are able to identify and disentangle two competing systematic effects that influence the accuracy of such measurements. Our findings prompt a reassessment of results from previous high-precision lifetime measurements that used similar equipment and methods.

  5. The Importance of Three-Body Interactions in Molecular Dynamics Simulations of Water with the Fragment Molecular Orbital Method

    Energy Technology Data Exchange (ETDEWEB)

    Pruitt, Spencer R.; Nakata, Hiroya; Nagata, Takeshi; Mayes, Maricris; Alexeev, Yuri; Fletcher, Graham D.; Fedorov, Dmitri G; Kitaura, Kazuo; Gordon, M

    2016-04-12

    The analytic first derivative with respect to nuclear coordinates is formulated and implemented in the framework of the three-body fragment molecular orbital (FMO) method. The gradient has been derived and implemented for restricted Hartree-Fock, second-order Møller-Plesset perturbation, and density functional theories. The importance of the three-body fully analytic gradient is illustrated through the failure of the two-body FMO method during molecular dynamics simulations of a small water cluster. The parallel implementation of the fragment molecular orbital method, its parallel efficiency, and its scalability on the Blue Gene/Q architecture up to 262,144 CPU cores, are also discussed.

  6. 学龄前儿童屈光不正性弱视治疗的临床观察%Clinical observation on treating preschoolers refractive amblyopia

    Institute of Scientific and Technical Information of China (English)

    李丽

    2012-01-01

      目的:探讨不同类型屈光矫正对学龄前弱视儿童治疗的临床观察.方法:对262例儿童弱视资料整理,屈光不正性弱视102例,屈光参差性弱视42例,斜视性弱视38例,所有儿童均采用散瞳后配戴矫正眼镜,3~6个月复查1次,根据视力、眼位、弱视类型等情况每半年到1年重新验光调整眼镜.结果:本组共262例,其中屈光参差性弱视基本治愈率38.78%,近视性弱视治愈率50.28%,散光性弱视和远视性弱视治愈率85.62%和87.38%.结论:不同类型的屈光矫正,治疗效果对弱视儿童疗效差异很大,与弱视的程度、配戴达到最佳视力的配镜度数有重要关系.%  Objective: To investigate the clinical observation of treating preschool children with amblyopia by different type of refractive. Methods: Sorted out 262 cases of children amblyopia information,102 cases of refractive amblyopia,42 cases of anisometropic amblyopia,38 cases of strabismic amblyopia, all children wear corrective glasses,3~6 months to review once, According to the vision, eye position, and the type of amblyopia, every six months to a year to re-optometry adjust glasses. Results:262 cases in the group, the anisometropic amblyopia basic cure rate was 38.78%,50.28% of the myopic amblyopia, the astigmatism, amblyopia and hyperopia amblyopia cure rate was 85.62% and 87.38%. Conclusion: The effect of different types of refractive and therapeutic on children with amblyopia great differences efficacy, that has important relationship between the degree of amblyopia and the best vision glasses degrees.

  7. Satisfaction with activity and participation in patients with stroke

    OpenAIRE

    Bouffioulx, Edouard

    2011-01-01

    Stroke is the most common cause of severe adult disability in the western world (Greenwood et al. 2009) and a major health problem all over the world (Kendall et al. 2007; Proot et al. 2002; Wade et al. 1987; Yu-Ying et al. 2002). In Belgium, the incidence of stroke is estimated at 2.62 per 1000 persons (Buntinx et al. 2002). Stroke may affect the social roles of the patient and it is therefore important to take into account the concept of social participation and the environmental and person...

  8. Perceived parenting and social support: can they predict academic achievement in Argentinean college students?

    OpenAIRE

    de la Iglesia G; Freiberg Hoffmann A; Fernández Liporace M

    2014-01-01

    Guadalupe de la Iglesia,1,2 Agustin Freiberg Hoffmann,2 Mercedes Fernández Liporace1,2 1National Council of Scientific and Technical Research (CONICET), 2University of Buenos Aires, Buenos Aires, Argentina Abstract: The aim of this study was to test the ability to predict academic achievement through the perception of parenting and social support in a sample of 354 Argentinean college students. Their mean age was 23.50 years (standard deviation =2.62 years) and most of them (83.3%...

  9. Response of C57Bl/6 mice to a carbohydrate-free diet

    OpenAIRE

    Borghjid Saihan; Feinman Richard

    2012-01-01

    Abstract High fat feeding in rodents generally leads to obesity and insulin resistance whereas in humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect of poor regulation of glucose and insulin. A previous study of C57Bl/6 mice (Kennedy AR, et al.: Am J Physiol Endocrinol Metab (2007) 262 E1724-1739) appeared to show the kind of beneficial effects of calorie restriction that is seen in humans but that diet was unusually low in protein (5%). In the cu...

  10. Songs for funerals and intercession. A collection of polyphony for the confraternity of St Barbara at the Corbie Abbey, Amiens, Bibliothèque Centrale Louis Aragon, MS 162 D. Edited by Peter Woetmann Christoffersen. Volume 1

    DEFF Research Database (Denmark)

    Christoffersen, Peter Woetmann

    2015-01-01

    deliverate moves to ensure local support for the building project. The MS offers music whose sound may compare with contemporary art music in fullness and solemnity, but monks who were neither able to read modern mensural notation nor improvise simple polyphony could perform it. Their competence in singing...... organized in a linear form as two PDF books in A4/Letter format: Volume 1 – Introduction and appendices (96 pp.), volume 2 – Edition of the manuscript with the commentary, lists of sources and bibliography (262 pp.)....

  11. Repression of the Escherichia coli modABCD (molybdate transport) operon by ModE.

    OpenAIRE

    Grunden, A M; Ray, R M; Rosentel, J K; Healy, F. G.; Shanmugam, K. T.

    1996-01-01

    The modABC gene products constitute the molybdate-specific transport system in Escherichia coli. Another operon coding for two proteins which diverges from the modABCD operon has been identified. The first gene of this operon codes for a 262-amino-acid protein, designated ModE (28 kDa), and the second genes codes for a 490-amino-acid protein. ModF (54 kDa). The role of ModF has not yet been determined; however, mutations in modE depressed modABCD transcription even in the presence of molybdat...

  12. 78 FR 76787 - Position Limits for Derivatives

    Science.gov (United States)

    2013-12-19

    ... 15,262 14,964 1,600 1,500 CME Milk Class III (DA). 2011 55,567 57,490 3,300 3,400 3,400 2012 47,378 47,064 3,100 3,100 CME Feeder Cattle (FC).. 2011 44,611 43,730 3,000 3,000 3,000 2012 44,984 43,651 3...,400 CME Live Cattle (LC).... 2011 433,581 440,229 12,800 12,900 12,900 2012 409,501 417,037 12,200...

  13. Chromosomal localization of murine and human oligodendrocyte-specific protein genes

    Energy Technology Data Exchange (ETDEWEB)

    Bronstein, J.M.; Wu, S.; Korenberg, J.R. [UCLA School of Medicine, Los Angeles, CA (United States)] [and others

    1996-06-01

    Oligodendrocyte-specific protein (OSP) is a recently described protein present only in myelin of the central nervous system. Several inherited disorders of myelin are caused by mutations in myelin genes but the etiology of many remain unknown. We mapped the location of the mouse OSP gene to the proximal region of chromosome 3 using two sets of multilocus crosses and to human chromosome 3 using somatic cell hybrids. Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions. 24 refs., 2 figs.

  14. High risk of peripheral arterial disease in the United Kingdom: 2-year results of a prospective registry.

    Science.gov (United States)

    Stansby, Gerard; Mister, Rebecca; Fowkes, Gerry; Roughton, Michael; Nugara, Fiona; Brittenden, Julie; Bradbury, Andrew; Ashley, Simon; Shearman, Cliff; Hannon, Ray; Flather, Marcus

    2011-02-01

    We report a prospective 2-year, multicenter study of patients presenting with intermittent claudication (IC; ankle brachial blood pressure index, ABPI ≤ 0.9). Mean age of the 473 patients enrolled was 68 years, 20% were diabetics, 30% had prior symptomatic coronary heart disease (CHD), 7% had prior stroke, and 39% were current smokers. At baseline, 26.2% of patients had BP ≤ 140/85 mm Hg or lower and at 2 years this figure was 32.5% (P = .01). Current smokers had fallen to 27% (from 39%) at 2 years (P ABPI. PMID:21220371

  15. High-Resolution Dating of Stalagmites and Reconstruction of Paleo-Environments

    Institute of Scientific and Technical Information of China (English)

    王兆荣; 袁道先; 林玉石; 张美良; 周杰; 刘卫国

    2001-01-01

    The discovery of abrupt paleo-climate change events and the prediction of environ mental changes in the future time have raised an urgent request for high-resolution paleo-envi rormental records. This paper reviews the progress made in chronology and paleo-environment of stalagmites from karst caves in China and presents some of the results of TIMS-U-series dat ing of stalagmites composed of secondary carbonates, taken from the Dongge, Longquan and Yamen karst caves in Libo County and the Qixing karst cave in Duyun, Guizhou Province, on a MAT-262 mass spectrometer.

  16. The (Impossibilit y of Time Travel: Haiti ’s Pre- and Post-Earthquake Futures

    Directory of Open Access Journals (Sweden)

    Landon Yarrington

    2012-12-01

    Full Text Available Review of:Travesty in Haiti: A True Account of Christian Missions, Orphanages, Fraud, Food Aid and Drug Trafficking [second edition]. Timothy T. Schwartz. Charleston SC: Booksurge, 2010. xlvii + 262 pp. (Paper US$ 15.99Haiti in the Balance: Why Foreign Aid Has Failed and What We Can Do About It. Terry Buss . Washington DC: Brookings Institute Press, 2008. xvi + 230 pp. (Paper US$ 28.95Backpacks Full of Hope: The UN Mission in Haiti. Eduardo Aldunate. Waterloo ON: Wilfrid Laurier University Press, 2010. xx + 230 pp. (Paper US$ 34.95

  17. An Unexplained 10 Degree - 40 Degree Shift in the Location of Some Diverse Neutral Atom Data at 1 AU

    CERN Document Server

    Collier, M; Simpson, D; Roberts, A; Szabo, A P; Fuselier, S; Wurz, P; Lee, M A; Tsurutani, B T; Collier, Michael R.; Moore, Thomas E.; Simpson, David; Roberts, Aaron; Szabo, Adam; Fuselier, Stephen; Wurz, Peter; Lee, Martin A.; Tsurutani, Bruce T.

    2003-01-01

    Four different data sets pertaining to the neutral atom environment at 1 AU are presented and discussed. These data sets include neutral solar wind and interstellar neutral atom data from IMAGE/LENA, energetic hydrogen atom data from SOHO/HSTOF and plasma wave data from the magnetometer on ISEE-3. Surprisingly, these data sets are centered between 262 degrees and 292 degrees ecliptic longitude, about 10 degrees - 40 degrees from the upstream interstellar neutral flow direction at 254 degrees resulting from the motion of the Sun relative to the local interstellar cloud. Some possible explanations for this offset, none of which is completely satisfactory, are discussed.

  18. 大英图书馆设在西约克郡的新楼即将开工

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    据英国AJPLUS网站报道,大英图书馆位于西约克郡波士顿温泉的新楼即将开工。由Atkins设计的这座建筑将容纳700多万本书籍和期刊。这些书籍存放在低氧环境下.“高密度、全自动化的书架”总长约262公里。

  19. Effect of substitution of corn for molasses in diet on growth performance, nutrient digestibility, blood characteristics, fecal noxious gas emission, and meat quality in finishing pigs

    OpenAIRE

    Shanmugam Sureshkumar; Sang In Lee; Doo Seok Nam; In Ho Kim

    2016-01-01

    ABSTRACT The objective of this experiment was to evaluate the effect of molasses as a substitute for corn in diet on growth performance, nutrient digestibility, blood characteristics, fecal noxious gas emission, and meat quality in finishing pigs. A total of 120 [(Landrace × Yorkshire) × Duroc] pigs with an average initial body weight (BW) of 54.21±2.62 kg were used in this experiment. Pigs were randomly assigned to 1 of the 3 dietary treatments on the basis of BW and sex (10 replicate pens p...

  20. Validity of Self-reported Birth Weight by Adult Women: Sociodemographic Influences and Implications for Life-Course Studies

    OpenAIRE

    Tehranifar, Parisa; Liao, Yuyan; Flom, Julie D.; Terry, Mary Beth

    2009-01-01

    Life-course epidemiologic studies frequently obtain data on perinatal and childhood factors through adult self-report. Data from a prospective US birth cohort of 262 women, born between 1959 and 1963 (average age at adult follow-up, 41.8 years), were used to assess the validity of self-reported birth weight category by sociodemographic characteristics. The effect of reporting error on the associations of birth weight with childhood and adult body mass index was evaluated by comparing the esti...

  1. PELATIHAN PENGENDALIAN VEKTOR DEMAM BERDARAH DENGUE DI KABUPATEN SUKOHARJO

    Directory of Open Access Journals (Sweden)

    Wiwik Trapsilowati

    2015-01-01

    Full Text Available AbstrakPartisipasi masyarakat melalui peran kader PSN membutuhkan pengetahuan dan keterampilan yang cukup. Penelitian ini dilakukan dengan memberikan pelatihan bagi kader PSN dengan tujuan untuk menilai peningkatan pengetahuan dan keterampilan kader PSN tentang DBD. Penelitian ini merupakan penelitian operasional dengan responden seluruh kader PSN yang ditunjuk oleh RT/RW setempat. Analisis data dilakukan dengan uji beda antara sebelum dan sesudah intervensi.Hasil penelitian menunjukkan rata-rata nilai pengetahuan kader PSN tentang DBD mengalami peningkatan yang signifikan dibandingkan sebelum intervensi dengan nilai t sebesar -13,543 dengan nilai signifikansi pada dua sisi (2-tailed sebesar 0,000 (p<0,05. Penilaian keterampilan dalam pemantauan jentik di daerah perlakuan pada evaluasi ke-3 menunjukkan perbedaan yang signifikan dengan nilai t hitung: -10,597 dan t tabel = 2,262 dan Sig (2-tailed = 0,000 (p<0,05 dan di daerah kontrol menunjukkan tidak ada beda dengan t hitung = 1,639 dan t tabel = 2,262, dan Sig (2-tailed sebesar 0,182 (p>0,05. Terjadinya penurunan nilai keterampilan kader PSN dalam pemantauan jentik perlu dilakukan penyegaran kembali secara berkala untuk pengendalian DBD khususnya yang dapat dilakukan oleh masyarakat.Kata Kunci : Pelatihan, Kader PSN, DBDAbstractCommunity participation through role PSN cadres needs sufficient knowledge and skills. This study conducted training for PSN cadres with the goal to assess the improvement of knowledge and skills of PSN cadres about dengue. This was operational research with total sampling of PSN cadres designated by the RT/RW. Data analysis was performed by premises difference test between before and after intervention. The results showed an average value of knowledge about dengue PSN cadre has increased significantly compared to before the intervention with t values: -13.543 with significance values  on the two sides (2-tailed: 0.000 (p<0.05. Assessment skills in monitoring larvae in

  2. Fluid Consumption by Mexican Women during Pregnancy and First Semester of Lactation

    OpenAIRE

    Homero Martinez

    2014-01-01

    The objective of this study was to describe daily fluid consumption in a sample of pregnant or lactating adult women. Women between 18 and 45 years of age, residents of Mexico City, stratified by socioeconomic status were asked to register their total fluid intake during 7 consecutive days. A total of 153 pregnant and 155 lactating women were recruited. On average, they drank 2.62 L/day and 2.75 L/day, respectively. Forty-one percent of pregnant women drank less than the recommended 2.3 L flu...

  3. Physical activity and physical fitness profiles of South African women

    OpenAIRE

    Smit, Madelein; Strydom, Gert Lukas; Wilders, Cilas Jacobus

    2011-01-01

    The purpose of this study was to determine the leisure time physical activity (LTPA) participation and physical fitness (PF) levels of South African women of the various ethnic groups. Individuals between the ages of 30 and 60 years (=41.0; ±=4.6) who were part of a cross-sectional non-randomized availability population who voluntarily participated, were used in this study. The group that formed part of the physical activity survey included 3273 subjects (Asian =262; black=1357; coloured=239;...

  4. Child Physical Abuse and concurrence of other types of Child Abuse : associations with health and risk behaviors

    OpenAIRE

    Annerbäck, Eva-Maria; Sahlqvist, L.; Svedin, Carl Göran; Wingren, Gun; Gustafsson, Per

    2012-01-01

    Objective: To examine the associations between child physical abuse and health problems/risk-taking behaviors among teen-agers. Further to evaluate concurrence of other types of abuse and how these alone and in addition to child physical abuse were associated with bad health status and risk-taking behaviors. Methods: A population-based survey was carried out in 2008 among all the pupils in two different grades (15 respectively 17 years old) in Södermanland County, Sweden (N=7 262). The respon...

  5. Dicty_cDB: Contig-U15372-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available art point 1124214 End point 1123961 Strand (PLUS/MINUS) MINUS Number of clones 1 ...54 Score = 262 bits (132), Expect = 2e-70 Identities = 135/135 (100%) Strand = Plus / Plus Query: 120 taaact... Expect = 4e-04 Identities = 23/24 (95%) Strand = Plus / Plus Query: 200 aataataataataatatantacaa 223 ||||||...Expect = 5.9 Identities = 14/14 (100%) Strand = Plus / Plus Query: 202 taataataataata 215 |||||||||||||| Sbj...9 Score = 40.1 bits (20), Expect = 0.002 Identities = 20/20 (100%) Strand = Plus

  6. Microbiological burden on the surfaces of Explorer 33 spacecraft.

    Science.gov (United States)

    Powers, E M

    1967-09-01

    The Explorer XXXIII Spacecraft (Anchored Interplanetary Monitoring Platform, or AIMP) was decontaminated to prevent gross contamination of the moon with terrestrial microorganisms. Assay of the total spacecraft surface before and after decontamination showed that the decontamination procedure reduced the viable microbiological burden from 1.40 x 10(6) to 3.60 x 10(4). However, assembly of parts which were not decontaminated for engineering reasons or were not assembled under cleanroom conditions increased the viable microbial burden at the time of launch to 2.62 x 10(5).

  7. 全国高校精品课程管理、制作及共享研讨会在京召开

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009年3月25日-26日,由全国高等学校教育技术协作委员会(CETA)和全国计算机辅助教育学会(CBE)联合主办的全国高校精品课程管理、制作及共享研讨会在北京香山饭店隆重召开。来自全国近138所高校的262位教师参加了这次研讨会。

  8. Níveis de retinol e carotenóides séricos e intercorrências gestacionais em puérperas Vitamin A serum and gestational intercurrences in postpartum women

    OpenAIRE

    Luciana Ferreira Campos; Cláudia Saunders; Andréa Ramalho; Mirian Martins Gomes; Elizabeth Accioly

    2008-01-01

    OBJETIVO: Investigar a associação entre intercorrências gestacionais e níveis de retinol e carotenóides em puérperas atendidas em maternidade pública do Rio de Janeiro. MÉTODOS: A amostra foi constituída por 262 puérperas atendidas na Maternidade Escola da Universidade Federal do Rio de Janeiro. O estado nutricional antropométrico foi avaliado pelo do índice de massa corporal pré-gestacional e pelo ganho ponderal gestacional, e foram coletadas informações sobre intercorrências gestacionais no...

  9. Influence of Thiamethoxam + Difenoconazol + Fludioxonil and time of conservation on rice seed germination.

    OpenAIRE

    Rafael Meneses; Jorge García de la Osa; Manuel Delgado Rigo

    2010-01-01

    Seed treatment has become of a great importance on principal crops, especially on intensive cropping, where sanitary protection is necessary from the days just after germination up to advanced growth stages of the crop. This experiment was carried out at the Entomology Laboratory of “Sur del Jibaro” Rice Experimental Station, Sancti Spiritus, Cuba, from July 28, 2009. Seed treatment with formulation of Thiamethoxam (262.5 g a.i./l) + Difeconazol (25 g a.i./l) + Fludioxonil (25 g a.i./l), equa...

  10. La matematica in pratica. Curricolo, performance e materialità nell'insegnamento e nell'apprendimento della matematica

    OpenAIRE

    POZZI, ALESSIA

    2013-01-01

    Questo lavoro è frutto di un’etnografia multisituata (Marcus, 1995) svolta nell’a.s. 2010-2011 in cinque istituti secondari di secondo grado di Roma ed all’interno dell’organizzazione che fa riferimento al progetto delle Olimpiadi della Matematica. Le Olimpiadi della Matematica sono un progetto volto alla valorizzazione delle “eccellenze” in matematica in base al decreto legislativo n. 262 del dicembre 2007, promosso dal Ministero dell’istruzione, dell’Università e della Ricerca, organizza...

  11. AcEST: DK952119 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 06 Definition sp|P98106|LYAM3_RAT P-selectin OS=Rattus norvegicus Align length 49 Score (bit) 31.6 E-value 4...262|YFP5_SCHPO Putative uncharacterized hydrolase C7D4.05 ... 30 9.1 >sp|P98106|LYAM3_RAT P-selectin OS=Ratt.........................................done Score E Sequences producing significant alignments: (bits) Value sp|P98106|LYAM3_RAT P-sel...ectin OS=Rattus norvegicus GN=Selp PE=2... 32 4.1 sp|O14

  12. 75 FR 65551 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

    Science.gov (United States)

    2010-10-25

    .../10 143,826,944 100,826,944 10/01/12 11/01/11 00-03-C-02-BIL, Billings, MT 09/16/10 5,163,262 3,278,253 10/01/05 04/01/04 05-04-C-01-BIL, Billings, MT 09/16/10 3,300,000 3,285,586 05/01/07 04/01/07 05... Hebert, Manager, Financial Analysis and Passenger Facility Charge Branch. BILLING CODE 4910-13-M...

  13. Ethanol production from wet oxidized corn straw by simultaneous saccharification and fermentation

    DEFF Research Database (Denmark)

    Zhang, Q.; Yin, Y.; Thygesen, Anders;

    2010-01-01

    In order to find out the appropriate process for ethanol production from corn straw, alkaline wet-oxidation pretreatment (195°C, 15 min, Na2CO3 2 g/L, O2 1200 kPa) and simultaneous saccharification and fermentation (SSF) were adopted to produce ethanol. The results showed that 90% of cellulose...... was obtained. The estimated total ethanol production was 262.7 kg/t raw material by assuming the consumption of both C-6 and C-5. No obvious inhibition effect occurred during SSF. These offered experiment evidences for ethanol production from corn straw....

  14. Stochastic growth logistic model with aftereffect for batch fermentation process

    Energy Technology Data Exchange (ETDEWEB)

    Rosli, Norhayati; Ayoubi, Tawfiqullah [Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Pahang (Malaysia); Bahar, Arifah; Rahman, Haliza Abdul [Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia); Salleh, Madihah Md [Department of Biotechnology Industry, Faculty of Biosciences and Bioengineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor (Malaysia)

    2014-06-19

    In this paper, the stochastic growth logistic model with aftereffect for the cell growth of C. acetobutylicum P262 and Luedeking-Piret equations for solvent production in batch fermentation system is introduced. The parameters values of the mathematical models are estimated via Levenberg-Marquardt optimization method of non-linear least squares. We apply Milstein scheme for solving the stochastic models numerically. The effciency of mathematical models is measured by comparing the simulated result and the experimental data of the microbial growth and solvent production in batch system. Low values of Root Mean-Square Error (RMSE) of stochastic models with aftereffect indicate good fits.

  15. Effects of a Pre-workout Supplement on Lean Mass, Muscular Performance, Subjective Workout Experience and Biomarkers of Safety

    OpenAIRE

    Kedia, A. William; Hofheins, Jennifer E; Habowski, Scott M; Ferrando, Arny A.; Gothard, M. David; Lopez, Hector L

    2014-01-01

    In this prospective, randomized, double-blind, trial conducted in two parts, we examined the effects of a multi-ingredient pre-exercise workout supplement blend of creatine, betaine and a dendrobium extract (MMP) on safety, performance, and body composition in healthy men and women undergoing a supervised program of resistance exercise. Part 1 was an acute hemodynamic safety study wherein forty young, healthy men and women (26.2 ± 5.3 years, 70.4 ± 3.3 inches, 83.7 ± 14.9 kg, 26.0 ± 3.2 kg●m-...

  16. Utilization of wild apricot kernel press cake for extraction of protein isolate

    OpenAIRE

    Sharma, P. C.; Tilakratne, B. M. K. S.; Gupta, Anil

    2010-01-01

    The kernels of apricot (Prunus armeniaca) stones are utilized for extraction of oil. The press cake left after extraction of oil was evaluated for preparation of protein isolate for its use in food supplementation. The apricot kernels contained 45–50% oil, 23.6–26.2% protein, 4.2% ash, 5.42% crude fibre, 8.2% carbohydrates and 90 mg HCN/100 g kernels, while press cake obtained after oil extraction contained 34.5% crude protein, which can be utilized for preparation of protein isolates. The me...

  17. Large-scale 100 % wood conversion with low-NO{sub x} values

    Energy Technology Data Exchange (ETDEWEB)

    Henry, Xavier; Mercier, Frederic [Laborelec s.c.r.l., Linkebeek (Belgium); Cavezzale, Paolo [Termokimik Corporation, Milan (Italy)

    2013-07-01

    The Max Green project in Rodenhuize, Belgium comprises conversion of the Rodenhuize unit 4 from coal combustion (262 MWe) into 100 % wood pellets combustion. With this conversion, the emission limit could only be achieved by secondary measured for reducing NO{sub x} requiring installation of a DENOX system. The SCR as part of the Max Green Project was realised successfully as a result of a specific design based on a dedicated research programme, the excellent cooperation between customer and contractor and the good management of the interfaces between boiler and SCR. (orig.)

  18. Revealing the Asymmetry of the Wind of the Variable Wolf-Rayet Star WR1 (HD4004) Through Spectropolarization

    OpenAIRE

    St-Louis, Nicole

    2013-01-01

    In this paper, high quality spectropolarimetric observations of the Wolf-Rayet (WR) Star WR1 (HD4004) obtained with ESPaDOnS at CFHT are presented. All major emission lines present in the spectrum show depolarization in the relative Stokes parameters Q/I and U/I. From the behaviour of the amount of line depolarization as a function of line strength, the intrinsic continuum light polarization of WR1 is estimated to be P/I=0.443 \\pm 0.028 % with an angle of \\theta=-26.2^o. Although such a level...

  19. 12  mJ kW-class ultrafast fiber laser system using multidimensional coherent pulse addition.

    Science.gov (United States)

    Kienel, Marco; Müller, Michael; Klenke, Arno; Limpert, Jens; Tünnermann, Andreas

    2016-07-15

    An ultrafast fiber-chirped-pulse amplification system using a combination of spatial and temporal coherent pulse combination is presented. By distributing the amplification among eight amplifier channels and four pulse replicas, up to 12 mJ pulse energy with 700 W average power and 262 fs pulse duration have been obtained with a system efficiency of 78% and excellent beam quality. To the best of our knowledge, this is the highest energy achieved by an ultrafast fiber-based laser system to date. PMID:27420531

  20. 集成电路%Integrated Circuits

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    具有点测光功能的CMOS图像传感器;6通道编码器模块;内置VCXO的高性能时钟发生器;集成滑动条或滚轮的触摸传感器;262K QQVGA CSTN液晶显示驱动器;高度集成的200V立体声驱动器;串行数字接口时钟恢复器;……