WorldWideScience

Sample records for body morphological clinical

  1. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey)

    DEFF Research Database (Denmark)

    Jensen, K; Gluud, C

    1994-01-01

    To aid understanding of markers of disease and predictors of outcome in alcohol-exposed systems, we undertook a literature survey of more than 700 articles to view the morphological characteristics and the clinical and experimental epidemiology of the Mallory body. Mallory bodies are filaments...... suggest a hit-and-run effect of alcohol, whereas other chronic liver diseases show evidence of gradual increase in prevalence of Mallory bodies with severity of hepatic pathology. Mallory bodies in cirrhosis do not imply alcoholic pathogenesis. Obesity, however, is associated with alcoholism and diabetes...

  2. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey).

    Science.gov (United States)

    Jensen, K; Gluud, C

    1994-10-01

    To aid understanding of markers of disease and predictors of outcome in alcohol-exposed systems, we undertook a literature survey of more than 700 articles to view the morphological characteristics and the clinical and experimental epidemiology of the Mallory body. Mallory bodies are filaments of intermediate diameter that contain intermediate filament components (e.g., cytokeratins) observable by conventional light microscopy or immunohistochemical methods, identical in structure regardless of initiating factors or putative pathogenesis. Although three morphological types can be identified under electron microscopy (with fibrillar structure parallel, random or absent), they remain stereotypical manifestations of hepatocyte injury. A summary of the conditions associated with Mallory bodies in the literature and their validity and potential etiological relationships is presented and discussed, including estimates on the combined light microscopic and immunohistochemical prevalences and kinetics. Emphasis is placed on proper confounder control (in particular, alcohol history), which is highly essential but often inadequate. These conditions include (mean prevalence of Mallory bodies in parentheses): Indian childhood cirrhosis (73%), alcoholic hepatitis (65%), alcoholic cirrhosis (51%), Wilson's disease (25%), primary biliary cirrhosis (24%), nonalcoholic cirrhosis (24%), hepatocellular carcinoma (23%), morbid obesity (8%) and intestinal bypass surgery (6%). Studies in alcoholic hepatitis strongly suggest a hit-and-run effect of alcohol, whereas other chronic liver diseases show evidence of gradual increase in prevalence of Mallory bodies with severity of hepatic pathology. Mallory bodies in cirrhosis do not imply alcoholic pathogenesis. Obesity, however, is associated with alcoholism and diabetes, and Mallory bodies are only present in diabetic patients if alcoholism or obesity complicates the condition. In addition, case studies on diseases in which Mallory bodies

  3. Body composition in clinical practice.

    Science.gov (United States)

    Andreoli, Angela; Garaci, Francesco; Cafarelli, Francesco Pio; Guglielmi, Giuseppe

    2016-08-01

    Nutritional status is the results of nutrients intake, absorption and utilization, able to influence physiological and pathological conditions. Nutritional status can be measured for individuals with different techniques, such as CT Body Composition, quantitative Magnetic Resonance Imaging, Ultrasound, Dual-Energy X-Ray Absorptiometry and Bioimpendance. Because obesity is becoming a worldwide epidemic, there is an increasing interest in the study of body composition to monitor conditions and delay in development of obesity-related diseases. The emergence of these evidence demonstrates the need of standard assessment of nutritional status based on body weight changes, playing an important role in several clinical setting, such as in quantitative measurement of tissues and their fluctuations in body composition, in survival rate, in pathologic condition and illnesses. Since body mass index has been shown to be an imprecise measurement of fat-free and fat mass, body cell mass and fluids, providing no information if weight changes, consequently there is the need to find a better way to evaluate body composition, in order to assess fat-free and fat mass with weight gain and loss, and during ageing. Monitoring body composition can be very useful for nutritional and medical interventional. This review is focused on the use of Body Composition in Clinical Practice. PMID:26971404

  4. Body composition in clinical practice.

    Science.gov (United States)

    Andreoli, Angela; Garaci, Francesco; Cafarelli, Francesco Pio; Guglielmi, Giuseppe

    2016-08-01

    Nutritional status is the results of nutrients intake, absorption and utilization, able to influence physiological and pathological conditions. Nutritional status can be measured for individuals with different techniques, such as CT Body Composition, quantitative Magnetic Resonance Imaging, Ultrasound, Dual-Energy X-Ray Absorptiometry and Bioimpendance. Because obesity is becoming a worldwide epidemic, there is an increasing interest in the study of body composition to monitor conditions and delay in development of obesity-related diseases. The emergence of these evidence demonstrates the need of standard assessment of nutritional status based on body weight changes, playing an important role in several clinical setting, such as in quantitative measurement of tissues and their fluctuations in body composition, in survival rate, in pathologic condition and illnesses. Since body mass index has been shown to be an imprecise measurement of fat-free and fat mass, body cell mass and fluids, providing no information if weight changes, consequently there is the need to find a better way to evaluate body composition, in order to assess fat-free and fat mass with weight gain and loss, and during ageing. Monitoring body composition can be very useful for nutritional and medical interventional. This review is focused on the use of Body Composition in Clinical Practice.

  5. Three-dimensional Morphological Analysis for Geological Bodies and Application

    Directory of Open Access Journals (Sweden)

    Yanhong Zou

    2011-06-01

    Full Text Available To address the spatial Morphological analysis of complex geological bodies in stereoscopic quantitative prediction of concealed ore bodies, a three-dimensional morphological analysis method for geological bodies based on 3-dimensional raster model under visualization environment was put forward by combining mathematical morphology with Euclidean distance transform theory. Firstly, the 3-dimensional visualization models for geological bodies were constructed on the basis of the 3-dimensional geological modeling (3DGM technology; Secondly, the algorithm for extracting the surface shape trend of geological body with the 3-dimensional raster model was proposed by using mathematical morphology filtering. By the combination of morphological filtering, global set operation and three-dimensional Euclidean distance transform, the models for the quantitative analysis and hierarchical extraction of the shape undulance were established. Lastly, as a case study, the three-dimensional morphological analysis method was applied in analyzing quantitatively the Xinwuli magmatic body in Fenghuangshan ore field in Tongling, Anhui Province. By means of the calculation model of Euclidean distance field, the quantitative extraction of the shape trend and shape undulance as well as the angle between geological interface and trend surface, as the quantitative indexes of geological ore-controlling factors, were achieved after building the 3D raster models of the magmatic body. The results show that the morphological analysis method is feasible to calculate various morphological parameters of complex geological bodies and extract quantitative indexes of geological ore-controlling factors successfully for stereoscopic quantitative predication of concealed ore bodies.

  6. [Clinical and morphological observation of purulent iliopsoitis].

    Science.gov (United States)

    Корнилова, Ирина В; Совгиря, Светлана Н; Винник, Наталия И; Прилуцкий, Алексей К; Старченко, Иван И

    2016-01-01

    The article describes the modern literary data on classification, etiology, pathogenesis and predisposing factors in the development of purulent iliopsoitis. Where are clinical and morphological analysis of five deaths cases of purulent ileopsoitis. On the basis of these studies found that purulent ileopsoitis that occur in middle and old age, are more common in women, can be either unilateral or bilateral localization. Purulent ileopsoitis arises by forming abscess in the iliopsoas muscle. Primary ileopsoitis arises in connection with injuries gluteal and lumbar region. Secondary ileopsoit developed as a complication of inflammatory and neoplastic processes, with an initial mechanism for the development of the pathological process were necrotic changes in the external iliac lymph nodes. In vivo it is difficult to diagnose, that`s why is necessary to apply a comprehensive study, including clinical data, anamnesis, general clinical and laboratory parameters, instrumental methods. PMID:27487553

  7. Clinical and morphological features of carcinoid tumors

    Directory of Open Access Journals (Sweden)

    Markovskiy V.D.

    2013-01-01

    Full Text Available Carcinoid tumors are rare tumors in practice of doctors of various specialties. These tumors are histological findings in the most cases because they are masked by clinical and morphological features of neoplastic and non-neoplastic diseases. In some cases, carcinoid tumors generally remain undetected due to lack of awareness among physicians about clinical and morphological characteristics of such disease. Believe it is important to recall the features of this tumor. The article presents the literature data and own observations from practice of carcinoid tumor of rare localization: bronchus, colon, mammary gland. In all three of our observations, where cancer was clinically suspected, the diagnosis of carcinoid tumor was made only after histology. Only complications have led to the surgical intervention, and, unfortunately, the diagnosis of carcinoid was made after death. In the latter case carcinoid most likely played an important role in thanatogenesis. Unification of efforts of doctors in various fields will make progress in the diagnosis and treatment of carcinoid tumors, extending the lives of patients suffering from this disorder.

  8. Measurements of body protein for clinical investigation

    International Nuclear Information System (INIS)

    Body protein (nitrogen) is determined by bilaterally irradiating the body with neutrons using Pu-Be sources and measuring the resultant 10.8 MeV gamma rays from the reaction 14N(n,8) 15N. In the authors lab the whole body can be scanned or separate segments of the body can be measured independently. A nitrogen index has been developed based on body size and is used as a predictor of normal total body nitrogen (TBN). They have found that TBN, when normalized to body size in this way, provides a reliable index of protein status which cannot be accurately determined by body weight, anthropometry, or body potassium measurements. Changes in body composition with age were studied by measuring the composition of 56 healthy female volunteers aged 20-80. Measurements were made for K(40K), Ca and N. It was shown that protein and bone mineral decrease with age but that this is not reflected in K or anthropometry measurements. Results of other studies to be presented include: body protein measurements pre and post TPN (total parenteral nutrition), nutritional status of patients on long term CAPD (continuous ambulatory peritoneal dialysis) and changes in body composition as a result of TPN in patients with small cell lung cancer receiving chemotherapy. Clinical results show that indirect measurements of body protein based on weight, potassium, or anthropometry, do not give an accurate measure of body protein. For an accurate measurement, direct measurement of body protein is necessary

  9. Myeloproliferative neoplasms: Morphology and clinical practice.

    Science.gov (United States)

    Barbui, Tiziano; Thiele, Jürgen; Vannucchi, Alessandro M; Tefferi, Ayalew

    2016-06-01

    In myeloproliferative neoplasms (MPNs), controversy persists regarding the usefulness and reproducibility of bone marrow (BM) features. Disagreements concerning the WHO classification are mainly focused on the discrimination between essential thrombocythemia (ET) and prefibrotic/early primary myelofibrosis (prePMF) and prodromal polycythemia vera (PV). Criticism mostly refers to lack of standardization of distinctive BM features precluding correct morphological pattern recognition. The distinction between WHO-defined ET and prePMF is not trivial because outcome is significantly worse in prePMF. Morphology was generally considered to be non-specific for the diagnosis of PV. Recent studies have revealed under-diagnosis of morphologically and biologically consistent PV. PMID:26718907

  10. Refsum disease. Clinical and morphological report on a case.

    Science.gov (United States)

    Savettieri, G; Camarda, R; Galatioto, S; Bonavita, V

    1982-10-01

    An atypical case of Refsum disease is reported together with the peripheral nerve morphological data. The body fluids must be assayed for phytanic acid whenever an atypical chronic peripheral neuropathy is observed.

  11. Thyroid endocrine disruption and external body morphology of Zebrafish

    Science.gov (United States)

    Sharma, Prakash; Grabowski, Timothy B.; Patino, Reynaldo

    2016-01-01

    This study examined the effects thyroid-active compounds during early development on body morphology of Zebrafish (Danio rerio). Three-day postfertilization (dpf) larvae were exposed to goitrogen [methimazole (MZ, 0.15 mM)], combination of MZ (0.15 mM) and thyroxine (T4, 2 nM), T4 (2 nM), or control (reconstituted water) treatments until 33 dpf and subsequently maintained in reconstituted water until 45 dpf. Samples were taken at 33 and 45 dpf for multivariate analysis of geometric distances between selected homologous landmarks placed on digital images of fish, and for histological assessment of thyrocytes. Body mass, standard length, and pectoral fin length were separately measured on remaining fish at 45 dpf. Histological analysis confirmed the hypothyroid effect (increased thyrocyte height) of MZ and rescue effect of T4 co-administration. Geometric distance analysis showed that pectoral and pelvic fins shifted backward along the rostrocaudal axis under hypothyroid conditions at 45 dpf and that T4 co-treatment prevented this shift. Pectoral fin length at 45 dpf was reduced by exposure to MZ and rescued by co-administration of T4, but it was not associated with standard length. Methimazole caused a reduction in body mass and length at 45 dpf that could not be rescued by T4 co-administration, and non-thyroidal effects of MZ on body shape were also recognized at 33 and 45 dpf. Alterations in the length and position of paired fins caused by exposure to thyroid-disrupting chemicals during early development, as shown here for Zebrafish, could affect physical aspects of locomotion and consequently other important organismal functions such as foraging, predator avoidance, and ultimately survival and recruitment into the adult population. Results of this study also suggest the need to include rescue treatments in endocrine disruption studies that rely on goitrogens as reference for thyroid-mediated effects.

  12. [Cystic formations of ovaries in women: clinical and morphological features

    Directory of Open Access Journals (Sweden)

    Sorokina I.V.

    2015-06-01

    Full Text Available Background. Cystic formations of ovaries are an urgent problem of medicine due to the high incidence of these diseases in women, the difficulties of differential diagnosis and a high percentage of diagnostic and tactical mistakes leading to disruption of reproductive function. Objective: to identify the clinical and morphological features of cystic formations of ovaries in women of Kharkiv region on the basis of the analysis of archival material. Methods. The material of this study was archival materials of pathological anatomy department of The Municipal Health Care Institution «Regional Clinical Hospital – The Center of Emergency Medicine and Disaster Medicine» during 2013 y. 354 cases of histological examination of surgical material – deleted fragments of ovaries due to cystic formations or ovaries in complex with uterus and fallopian tubes due to leiomyoma of uterus – were analyzed. The slides, stained with hematoxylin and eosin, were studied on the microscope «Olympus BX-41». Digital data were processed using statistical methods of investigation. Results. 1. It was established that in women of Kharkiv region among all cystic formations of ovaries tumor-like processes (in order of frequency of occurrence – yellow bodies cysts, follicular cysts, simple cysts, endometrial cysts occur 5.5 times more frequently in comparison with tumor processes (in order of frequency of occurrence – dermoid cysts, cystadenomas, cystadenocarcinoma. 2. Tumor and tumor-like cystic formations of ovaries occur 4.6 times more frequently in right ovary in comparison with the left. 3. Tumor and tumor-like cystic formations of ovaries were characterized by a certain age. Tumor-like cystic formations of ovaries were typical for younger women (average age of women – 31.03±0.49 year and tumor cystic formations – for older women (average age of women – 37.70±1.53 years. Among all tumor-like cystic formations of ovaries yellow bodies cysts were typical

  13. Iga nephropathy: clinical-morphologic correlation

    Directory of Open Access Journals (Sweden)

    Basta-Jovanović Gordana M.

    2003-01-01

    Full Text Available IgA nephropathy is glomerular disease caracterized by the presencemorphologic changes as wella as the prognosis is in correlation with of IgA dominant or codominant imunoglobuline deposits in glomer-the amount of proteinuria. The prognosis is better in children. ular mesangium which can be demostrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or mikroskopic, isolated or combined with proteinuria, which can be of nephrotic range. The prognosis o the disease is better if presented with haematuria. Intensity of????.

  14. X-ray morphology of the eburnated vertebral body - diagnostic and differential diagnostic problems

    Energy Technology Data Exchange (ETDEWEB)

    Krug, B.; Lorenz, R.; Steinbrich, W.

    1988-08-01

    1. Numerous diseases may become manifest as eburnated vertebral bodies, and hence the X-ray morphological sign of eburnation is an unspecific one. Isolated characteristics such as the involvement of one or several vertebrae, an intact vertebral space, a broadening of the paravertebral accompanying shadow, and the remaining radiological skeletal status enable narrowing down the differential diagnosis, although anamnesis and clinical findings will supply the main pointers. 2. In primary tumorous eburnations radiotherapy or chemotherapy will render an X-ray morphological assessment of therapeutic success impossible. 3. In primary diagnosis of an eburnated vertebral body it is possible to apply sonography. CT and MR as diagnostic tools step by step to narrow down the differential diagnosis by detecting or excluding pathological abdominal processes such as liver or lymphatic node metastases, paravertebral or intraspinal soft-part dense space-occupying growths or bone infiltration, but it will only rarely be possible to classify the phenomenon properly as being caused by a well-defined process, even if CT and MR are employed.

  15. Evaluation of morphological indices and total body electrical conductivity to assess body composition in big brown bats

    Science.gov (United States)

    Pearce, R.D.; O'Shea, T.J.; Wunder, B.A.

    2008-01-01

    Bat researchers have used both morphological indices and total body electric conductivity (TOBEC) as proxies for body condition in a variety of studies, but have typically not validated these indices against direct measurement of body composition. We quantified body composition (total carcass lipids) to determine if morphological indices were useful predictors of body condition in big brown bats (Eptesicus fuscus). We also evaluated body composition indirectly by TOBEC using EM-SCAN?? technology. The most important predictors of body composition in multiple regression analysis were body mass-to-forearm ratio (partial r2 = 0.82, P < 0.001) followed by TOBEC measurement (partial r2 = 0.08, P < 0.001) and to a minor extent head length (partial r2 = 0.02, P < 0.05). Morphological condition indices alone may be adequate for some studies because of lower cost and effort. Marking bats with passive integrated transponder (PIT) tags affected TOBEC measurements. ?? Museum and Institute of Zoology PAS.

  16. Clinical and morphological characteristics of chronic duodenitis in children

    OpenAIRE

    Tishchenko D.V.; Matveeva O.V.; Chernenkov Yu.V.; Maslyakova G.N.; Bucharskaya A.B.

    2012-01-01

     

    The research goal is to determine clinical, endoscopic and morphological signs of chronic duodenitis in children. Materials and methods: The diagnostic value of molecular markers has been revealed by immunohistochemical research of biopsy. It has been received from endoscopic examination of 32 children aged from 3 to 17 years old with chronic duodenitis. Morphometric investigation of markers expression has been ca...

  17. Clinical and morphological features of hypertrophic cardiomyopathy in Korean patients.

    OpenAIRE

    Park, Y. B.; Lee, W S; Kim, D. K.; Choi, Y. S.; Seo, J. D.; Lee, Y. W.

    1989-01-01

    Thirty three cases of hypertrophic cardiomyopathy (HCMP) were reviewed to estimate the relative frequencies of the subtypes of HCMP and to clarify whether there is any racial difference in clinical and morphological features of HCMP. The diagnosis was made by echocardiography, cardiac catheterization and left ventriculography. Twenty four patients underwent coronary angiogram. Numbers of cases by the types of HCMP were 20 (61%) with asymmetrical septal hypertrophy (ASH), 11 (33%) with apical ...

  18. Immunohistochemical and Morphological Changes in Chipmunk Carotid Body during Hibernaiton

    OpenAIRE

    FUKUHARA, Kohko; YOSHIZAKI, Katsuaki; Wu, Yi; Senoo, Haruki; OHTOMO, Kazuo

    2004-01-01

    Mammalian hibernators experience drastic changes in vital signs such asbody temperature, respiratory rate, and heart rate during hibernation because of periodicarousals during which vital signs return to non-hibernating levels. The carotid body, anarterial chemoreceptor organ regulating respiration, contains several neuroactive substances.However, little is known about changes of neuroactive substances in the carotidbody during hibernation. Immunohistochemical study using antibodies against n...

  19. Three-dimensional morphological analysis method for geologic bodies and its parallel implementation

    Science.gov (United States)

    Mao, Xiancheng; Zhang, Bin; Deng, Hao; Zou, Yanhong; Chen, Jin

    2016-11-01

    It has been found that the spatial locations and distributions of orebodies, especially for certain hydrothermal mineral deposits, are closely related to the shape of intrusive geologic bodies. For complex and large-scale geologic bodies, however, it is challenging to achieve rigorous and quantitative morphological analysis by standard geological surface reconstruction and trend-surface analysis methods. This paper presents a novel, quantitative morphological analysis method for general geologic bodies of closed 2-manifold surface based on mathematical morphology. Through the processes of morphological filtering, set operations and three-dimensional Euclidean distance transform (3D-EDT), the global trend shape, local convex and concave zones as well as degree of surface undulation of a geologic body are extracted respectively. All of the three analysis phases are speeded up via parallel algorithms implemented by using the message passing interface (MPI) standard. The proposed method is tested with a case study of the Xinwuli intrusion with complex shape in Fenghuangshan deposit of the Tongling district, China. The results demonstrate that the method is an effective and efficient way to achieve quantitative morphological analysis, thereby decreasing the time necessary to find the association between morphological parameters of geologic bodies and mineralization.

  20. Surface morphology of chitin highly related with the isolated body part of butterfly (Argynnis pandora).

    Science.gov (United States)

    Kaya, Murat; Bitim, Betül; Mujtaba, Muhammad; Koyuncu, Turgay

    2015-11-01

    This study was conducted to understand the differences in the physicochemical properties of chitin samples isolated from the wings and the other body parts except the wings (OBP) of a butterfly species (Argynnis pandora). The same isolation method was used for obtaining chitin specimens from both types of body parts. The chitin content of the wings (22%) was recorded as being much higher than the OBP (8%). The extracted chitin samples were characterized via FT-IR, TGA, XRD, SEM, and elemental analysis techniques. Results of these characterizations revealed that the chitins from both structures (wings and OBP) were very similar, except for their surface morphologies. SEM results demonstrated one type of surface morphology for the wings and four different surface morphologies for the OBP. Therefore, it can be hypothesized that the surface morphology of the chitin is highly related with the body part.

  1. Morphological changes of carotid bodies in acute respiratory distress syndrome: a morphometric study in humans

    Directory of Open Access Journals (Sweden)

    Vinhaes E.N.G.

    2002-01-01

    Full Text Available Carotid bodies are chemoreceptors sensitive to a fall of partial oxygen pressure in blood (hypoxia. The morphological alterations of these organs in patients with chronic obstructive pulmonary disease (COPD and in people living at high altitude are well known. However, it is not known whether the histological profile of human carotid bodies is changed in acute clinical conditions such as acute respiratory distress syndrome (ARDS. The objective of the present study was to perform a quantitative analysis of the histology of carotid bodies collected from patients who died of ARDS. A morphometric study of carotid bodies collected during routine autopsies was carried out on three groups: patients that died of non-respiratory diseases (controls, N = 8, patients that presented COPD and died of its complications or associated diseases (N = 7, and patients that died of ARDS (N = 7. Morphometric measurements of the volume fraction of clusters of chief cells were performed in five fields on each slide at 40X magnification. The numerical proportion of the four main histological cell types (light, dark, progenitor and sustentacular cells was determined analyzing 10 fields on each slide at 400X magnification. The proportion of dark cells was 0.22 in ARDS patients, 0.12 in controls (P<0.001, and 0.08 in the COPD group. The proportion of light cells was 0.33 (ARDS, 0.44 (controls (P<0.001, and 0.36 (COPD. These findings suggest that chronic and acute hypoxia have different effects on the histology of glomic tissue.

  2. Body Dysmorphic Disorder and Other Clinically Significant Body Image Concerns in Adolescent Psychiatric Inpatients: Prevalence and Clinical Characteristics

    Science.gov (United States)

    Dyl, Jennifer; Kittler, Jennifer; Phillips, Katharine A.; Hunt, Jeffrey I.

    2006-01-01

    Background: This study assessed prevalence and clinical correlates of body dysmorphic disorder (BDD), eating disorders (ED), and other clinically significant body image concerns in 208 consecutively admitted adolescent inpatients. It was hypothesized that adolescents with BDD would have higher levels of depression, anxiety, and suicidality.…

  3. Pelvic morphology, body posture and standing balance characteristics of adolescent able-bodied and idiopathic scoliosis girls.

    Directory of Open Access Journals (Sweden)

    Georgios A Stylianides

    Full Text Available The purpose of this study was to determine how pelvic morphology, body posture, and standing balance variables of scoliotic girls differ from those of able-bodied girls, and to classify neuro-biomechanical variables in terms of a lower number of unobserved variables. Twenty-eight scoliotic and twenty-five non-scoliotic able-bodied girls participated in this study. 3D coordinates of ten anatomic body landmarks were used to describe pelvic morphology and trunk posture using a Flock of Birds system. Standing balance was measured using a force plate to identify the center of pressure (COP, and its anteroposterior (AP and mediolateral (ML displacements. A multivariate analysis of variance (MANOVA was performed to determine differences between the two groups. A factor analysis was used to identify factors that best describe both groups. Statistical differences were identified between the groups for each of the parameter types. While spatial orientation of the pelvis was similar in both groups, five of the eight trunk postural variables of the scoliotic group were significantly different that the able-bodied group. Also, five out of the seven standing balance variables were higher in the scoliotic girls. Approximately 60% of the variation is supported by 4 factors that can be associated with a set of variables; standing balance variables (factor 1, body posture variables (factor 2, and pelvic morphology variables (factors 3 and 4. Pelvic distortion, body posture asymmetry, and standing imbalance are more pronounced in scoliotic girls, when compared to able-bodied girls. These findings may be beneficial when addressing balance and ankle proprioception exercises for the scoliotic population.

  4. Occult Liver Abscess Following Clinically Unsuspected Ingestion of Foreign Bodies

    OpenAIRE

    Tsui, Ban CH; Mossey, J

    1997-01-01

    Two uncommon cases of foreign body (a wooden clothespin and a toothpick) perforation of the gut with associated pyogenic liver abscesses are presented. These cases illustrate the difficulties of preoperative diagnosis. The lack of history of ingestion of foreign bodies, variable clinical presentation of the conditions and radiolucent natures of the foreign bodies all play a role in impeding the diagnosis preoperatively. This report emphasizes the role of ultrasound and computed tomographic sc...

  5. Clinical and radiological diagnostic of foreign bodies in companion birds

    International Nuclear Information System (INIS)

    Sometimes curious foreign bodies placed in the proventriculus/ventriculus of companion birds are causes of single case diseases. Clinical signs include untypical symptoms such as distress, lameness, vomiting and diarrhoe. In cases of heavy metal intoxication, e.g. lead poisoning, CNS-disorders are found. Radiographs taken in a ventro-dorsal and a latero-lateral view show the presence of foreign bodies in suspicion. In most cases of foreign bodies in birds a surgical intervention (Gastrotomy) is indicated

  6. Occult liver abscess following clinically unsuspected ingestion of foreign bodies.

    Science.gov (United States)

    Tsui, B C; Mossey, J

    1997-01-01

    Two uncommon cases of foreign body (a wooden clothespin and a toothpick) perforation of the gur with associated pyogenic liver abscesses are presented. These cases illustrate the difficulties of preoperative diagnosis. The lack of history of ingestion of foreign bodies, variable clinical presentation of the conditions and radiolucent natures of the foreign bodies all play a role in impeding the diagnosis preoperatively. This report emphasizes the role of ultrasound and computed tomographic scan in evaluating similar cases. Any patient with known risk factors for ingestion of foreign body should arouse suspicion and be investigated further. PMID:9286481

  7. A model for estimating body shape biological age based on clinical parameters associated with body composition

    Directory of Open Access Journals (Sweden)

    Bae CY

    2012-12-01

    Full Text Available Chul-Young Bae,1 Young Gon Kang,2 Young-Sung Suh,3 Jee Hye Han,4 Sung-Soo Kim,5 Kyung Won Shim61MediAge Research Center, Seoul, Korea; 2Chaum Power Aging Center, College of Medicine, CHA University, Seoul, Korea; 3Health Promotion Center, Keimyung University Dongsam Medical Center, Daegu, Korea; 4Department of Family Medicine, College of Medicine, Eulji University, Seoul, Korea; 5Department of Family Medicine, College of Medicine, Chungnam National University, Daejeon, Korea; 6Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul, KoreaBackground: To date, no studies have attempted to estimate body shape biological age using clinical parameters associated with body composition for the purposes of examining a person's body shape based on their age.Objective: We examined the relations between clinical parameters associated with body composition and chronological age, and proposed a model for estimating the body shape biological age.Methods: The study was conducted in 243,778 subjects aged between 20 and 90 years who received a general medical checkup at health promotion centers at university and community hospitals in Korea from 2004 to 2011.Results: In men, the clinical parameters with the highest correlation to age included the waist-to-hip ratio (r = 0.786, P < 0.001, hip circumference (r = −0.448, P < 0.001, and height (r = −0.377, P < 0.001. In women, the clinical parameters with the highest correlation to age include the waist-to-hip ratio (r = 0.859, P < 0.001, waist circumference (r = 0.580, P < 0.001, and hip circumference (r = 0.520, P < 0.001. To estimate the optimal body shape biological age based on clinical parameters associated with body composition, we performed a multiple regression analysis. In a model estimating the body shape biological age, the coefficient of determination (R2 was 0.71 in men and 0.76 in women.Conclusion: Our model for estimating body shape biological age

  8. Clinical Usefulness of a New Equation for Estimating Body Fat

    OpenAIRE

    Gomez-Ambrosi, J.; Silva, C.; Catalan, V.; Rodriguez, A.; Galofre, J.C. (Juan Carlos); Escalada, J.; Valenti, V.; F. Rotellar; Romero, S; Ramirez, B; J. Salvador; G. Frühbeck

    2012-01-01

    OBJECTIVE: To assess the predictive capacity of a recently described equation that we have termed CUN-BAE (Clínica Universidad de Navarra-Body Adiposity Estimator) based on BMI, sex, and age for estimating body fat percentage (BF%) and to study its clinical usefulness. RESEARCH DESIGN AND METHODS: We conducted a comparison study of the developed equation with many other anthropometric indices regarding its correlation with actual BF% in a large cohort of 6,510 white subjects from b...

  9. Variations in Transverse Foramina of Cervical Vertebrae: Morphology & Clinical Importance

    Directory of Open Access Journals (Sweden)

    Vaishakhi Gonsai

    2015-12-01

    Full Text Available Background: The purpose of this study is to investigate variations in transverse foramina in the cervical vertebrae and its morphological and clinical importance. Materials and Method : The variations in the number and size of transverse foramina was studied in total 200 human dried cervical vertebrae, which were taken from the Department of Anatomy, B.J.Medical College, Ahmedabad. All the vertebrae were observed for variation in number and size of transverse foramina. Results: Out of 200 cervical vertebrae, complete double transverse foramina were observed in 40 vertebrae (20%, among them unilateral double foramina were found in 31 vertebrae (15.5% and the bilateral double foramina were found in 9 vertebrae (4.5%. Incomplete double transverse foramina were observed in 22 vertebrae (11%, among them unilateral double foramina were found in 16 vertebrae (8% and bilateral double foramina were observed in 6 vertebrae (3%. Conclusion: Complete unilateral double transverse foramina of cervical vertebrae were more common than bilateral. Also unilateral small size transverse foramina of cervical vertebrae were also common. This variation is important for the neurosurgeon during cervical surgery. Under such condition the course of the vertebral artery may be distorted. It is also useful for Radiologist during CT and MRI scan.

  10. Clinical and morphological characteristics of chronic duodenitis in children

    Directory of Open Access Journals (Sweden)

    Tishchenko D.V.

    2012-09-01

    Full Text Available

     

    The research goal is to determine clinical, endoscopic and morphological signs of chronic duodenitis in children. Materials and methods: The diagnostic value of molecular markers has been revealed by immunohistochemical research of biopsy. It has been received from endoscopic examination of 32 children aged from 3 to 17 years old with chronic duodenitis. Morphometric investigation of markers expression has been carried out by means of analyzing system of digital images of Mikrovizor medical uVizo-103. Results: The index of proliferation has been higher in cells of cover epithelium than in glands. The inductor expression of apoptosis Bax has been poorly expressed in both groups of patients. It has been proved that proliferative processes are predominant in this pathology. Conclusion: It has been found out that proliferation of significant activity in the cover epithelium accompanies the development of preatrophic processes in children with chronic duodenitis. The greater degree of regeneration has been marked in crypts.

  11. Body circumferences: clinical implications emerging from a new geometric model

    Directory of Open Access Journals (Sweden)

    Gallagher Dympna

    2008-10-01

    Full Text Available Abstract Background Body volume expands with the positive energy balance associated with the development of adult human obesity and this "growth" is captured by two widely used clinical metrics, waist circumference and body mass index (BMI. Empirical correlations between circumferences, BMI, and related body compartments are frequently reported but fail to provide an important common conceptual foundation that can be related to key clinical observations. A two-phase program was designed to fill this important gap: a geometric model linking body volume with circumferences and BMI was developed and validated in cross-sectional cohorts; and the model was applied to the evaluation of longitudinally monitored subjects during periods of voluntary weight loss. Concepts emerging from the developed model were then used to examine the relations between the evaluated clinical measures and body composition. Methods Two groups of healthy adults (n = 494 and 1499 were included in the cross-sectional model development/testing phase and subjects in two previous weight loss studies were included in the longitudinal model evaluation phase. Five circumferences (arm, waist, hip, thigh, and calf; average of sum, C, height (H, BMI, body volume (V; underwater weighing, and the volumes of major body compartments (whole-body magnetic resonance imaging were measured. Results The evaluation of a humanoid geometric model based a cylinder confirmed that V derived from C and H was highly correlated with measured V [R2 both males and females, 0.97; p 0.5. The scaling of individual circumferences to V/H varied, with waist the highest (V/H~0.6 and calf the lowest (V/H~0.3, indicating that the largest and smallest between-subject "growth" with greater body volume occurs in the abdominal area and lower extremities, respectively. A stepwise linear regression model including all five circumferences2 showed that each contributed independently to V/H. These cross

  12. Variations in leopard cat (Prionailurus bengalensis) skull morphology and body size: sexual and geographic influences.

    Science.gov (United States)

    Sicuro, Fernando L; Oliveira, Luiz Flamarion B

    2015-01-01

    The leopard cat, Prionailurus bengalensis (Kerr, 1792), is one of the most widespread Asian cats, occurring in continental eastern and southeastern Asia. Since 1929, several studies have focused on the morphology, ecology, and taxonomy of leopard cats. Nevertheless, hitherto there has been no agreement on basic aspects of leopard cat biology, such as the presence or absence of sexual dimorphism, morphological skull and body differences between the eleven recognized subspecies, and the biogeography of the different morphotypes. Twenty measurements on 25 adult leopard cat skulls from different Asian localities were analyzed through univariate and multivariate statistical approaches. Skull and external body measurements from studies over the last 77 years were assembled and organized in two categories: full data and summary data. Most of this database comprises small samples, which have never been statistically tested and compared with each other. Full data sets were tested with univariate and multivariate statistical analyses; summary data sets (i.e., means, SDs, and ranges) were analyzed through suitable univariate approaches. The independent analyses of the data from these works confirmed our original results and improved the overview of sexual dimorphism and geographical morphological variation among subspecies. Continental leopard cats have larger skulls and body dimensions. Skulls of Indochinese morphotypes have broader and higher features than those of continental morphotypes, while individuals from the Sunda Islands have skulls with comparatively narrow and low profiles. Cranial sexual dimorphism is present in different degrees among subspecies. Most display subtle sex-related variations in a few skull features. However, in some cases, sexual dimorphism in skull morphology is absent, such as in P. b. sumatranus and P. b. borneoensis. External body measurement comparisons also indicate the low degree of sexual dimorphism. Apart from the gonads, the longer hind

  13. Lobular breast cancer: Clinical, molecular and morphological characteristics.

    Science.gov (United States)

    Christgen, Matthias; Steinemann, Doris; Kühnle, Elna; Länger, Florian; Gluz, Oleg; Harbeck, Nadia; Kreipe, Hans

    2016-07-01

    Infiltrating lobular breast cancer (ILBC) is the most common special breast cancer subtype. This review provides a comprehensive description of ILBC characteristics, including epidemiology, clinical features, molecular genetics and histomorphology. Twenty detailed supplemental data tables guide through primary data of more than 200 original studies. Meta-analyses indicate that ILBC is at least twice as common in the Western world as it is in other geographic regions. ILBC is over-represented in so-called interval carcinomas and in primary metastatic breast cancer. ILBC is also associated higher age, higher pT stage and hormone receptor (ER/PR) positivity. Pathological complete response rates after neoadjuvant chemotherapy are low, ranging between 0% and 11%. Positive resection margins after breast-conserving surgery are comparatively frequent and 17% to 65% of patients undergo a second surgical intervention. Depending on the morphological stringency in the diagnosis of ILBC, lack of E-cadherin expression is observed in 55% to 100% of cases. CDH1/E-cadherin mutation detection rates vary between 12% and 83%. Various additional molecular factors, including PIK3CA, TP53, FOXA1, FGFR1, ZNF703 and BCAR4, have been implicated in ILBC or progression of lobular carcinoma in situ (LCIS) to invasive cancer and are discussed in detail. Eight instructive figure plates recapitulate the histomorphology of ILBC and its variants. Furthermore, we draw attention to rarely addressed histological details, such as two-sided nuclear compression and fat-avoiding growth at the invasion front. Last but not least, we discuss future translational research directions and emphasize the concept of synthetic lethality, which promises new options for targeted ILBC therapy.

  14. Morphology and Dynamics of Lithospheric Body Force Instabilities: Sheets, Drips and In-Between

    Science.gov (United States)

    Beall, A.; Moresi, L. N.

    2014-12-01

    Foundering of the Earth's lithosphere, and consequent energy and mass flux across the upper boundary layer and mantle interface, is driven locally by gravitational body forces. The related instabilities are usually classified as having sheet-like or drip-like morphologies. The former is associated with whole lithosphere (subduction) or delamination type foundering such as suggested for beneath the southern Sierra-Nevada and the Colorado Plateau, the latter to classic Rayleigh-Taylor instability below an upper layer, suggested to have occurred beneath the Tibetan Plateau and North Island, New Zealand. This dichotomy is non-trivial; classification of phenomena into one or the other is often debated and is difficult to infer from observables. The two morphologies are most likely end-members. Here I refine the dynamics driving morphology selection as a function of rheological lamination and boundary layer Rayleigh number in 2D and 3D, using the finite-element particle-in-cell code Underworld. I explore the influence of morphology on mass flux, topography and crustal deformation as well as deviation from classic 2D scalings. Additionally, tectonic displacement interference with instability development is discussed using basic 3D shear-box style models. By quantifying and describing the theoretical instability dynamics which could result in a plausible range of morphological expressions, I aim to build a general framework which can be paired to the discussion involving firstly, the recognition of varied styles of body force instabilities in the modern Earth and rock record and secondly, to what degree pattern selection impacts boundary layer mass and energy flux.

  15. Improving evolvability of morphologies and controllers of developmental soft-bodied robots with novelty search

    Directory of Open Access Journals (Sweden)

    Michał eJoachimczak

    2015-12-01

    Full Text Available Novelty search is an evolutionary search algorithm based on the superficially contradictory idea that abandoning goal focused fitness function altogether can lead to the discovery of higher fitness solutions. In the course of our work, we have created a biologically inspired artificial development system with the purpose of automatically designing complex morphologies and controllers of multicellular, soft-bodied robots. Our goal is to harness the creative potential of in silico evolution so that it can provide us with novel and efficient designs that are free of any preconceived notions a human designer would have. In order to do so, we strive to allow for the evolution of arbitrary morphologies. Using a fitness-driven search algorithm, the system has been shown to be capable of evolving complex multicellular solutions consisting of hundreds of cells that can walk, run and swim, yet the large space of possible designs makes the search expensive and prone to getting stuck in local minima. In this work, we investigate how a developmental approach to the evolution of robotic designs benefits from abandoning objective fitness function. We discover that novelty search produced significantly better performing solutions. We then discuss the key factors of the success in terms of the phenotypic representation for the novelty search, the deceptive landscape for co-designing morphology/brain, and the complex development-based phenotypic encoding.

  16. Vision in semi-aquatic snakes: Intraocular morphology, accommodation, and eye: Body allometry

    Science.gov (United States)

    Plylar, Helen Bond

    Vision in vertebrates generally relies on the refractive power of the cornea and crystalline lens to facilitate vision. Light from the environment enters the eye and is refracted by the cornea and lens onto the retina for production of an image. When an animal with a system designed for air submerges underwater, the refractive power of the cornea is lost. Semi-aquatic animals (e.g., water snakes, turtles, aquatic mammals) must overcome this loss of corneal refractive power through visual accommodation. Accommodation relies on change of the position or shape of the lens to change the focal length of the optical system. Intraocular muscles and fibers facilitate lenticular displacement and deformation. Snakes, in general, are largely unstudied in terms of visual acuity and intraocular morphology. I used light microscopy and scanning electron microscopy to examine differences in eye anatomy between five sympatric colubrid snake species (Nerodia cyclopion, N. fasciata, N. rhombifer, Pantherophis obsoletus, and Thamnophis proximus) from Southeast Louisiana. I discovered previously undescribed structures associated with the lens in semi-aquatic species. Photorefractive methods were used to assess refractive error. While all species overcame the expected hyperopia imposed by submergence, there was interspecific variation in refractive error. To assess scaling of eye size with body size, I measure of eye size, head size, and body size in Nerodia cyclopion and N. fasciata from the SLU Vertebrate Museum. In both species, body size increases at a significantly faster rate than head size and eye size (negative allometry). Small snakes have large eyes relative to body size, and large snakes have relatively small eyes. There were interspecific differences in scaling of eye size with body size, where N. fasciata had larger eye diameter, but N. cyclopion had longer eyes (axial length).

  17. Experimental aflatoxicosis in swine: morphological and clinical pathological results.

    OpenAIRE

    Miller, D M; Stuart, B P; Crowell, W A

    1981-01-01

    The morphological changes in livers of 30 feeder pigs fed diets containing corn contaminated by aflatoxins (0.0 microgram aflatoxins/g feed, 0.4 microgram aflatoxin/g feed, and 0.8 microgram aflatoxin/g feed) were compared with changes in hematology, liver specific serum enzymes, serum proteins, and lymphocyte stimulation indices. Histologically, the livers were classified into five groups. Pigs fed the 0.8 microgram/g diets had the most severe histological lesions of karyomegaly, bile ductu...

  18. Extensor digitorum brevis manus: Its clinical significance and morphology

    Directory of Open Access Journals (Sweden)

    Bolla SR

    2008-12-01

    Full Text Available Anomalous muscles are often a matter of concern to clinicians as they mislead the diagnosis. Knowledge of such variant muscles is important clinically to avoid misdiagnosis. In this report we present an anomalous muscle on the dorsum of hand, extensor digitorum brevis manus an uncommon variation present as a swelling on the dorsum. It is originated from the dorsal wrist capsule within the compartment deep to the extensor retinaculum for the extensor digitorum and inserted into the extensor hood of the index finger, this variant muscle often cause dorsal wrist pain and often confused as ganglion, soft tissue tumor, synovial cyst or tenovaginitis. The presence of such variant muscles on dorsum of hand, their clinical significance and literature has been reviewed.

  19. Relations of the morphological characteristic latent structure and body posture indicators in children aged seven to nine years.

    Science.gov (United States)

    Pausić, Jelena; Cavala, Marijana; Katić, Ratko

    2006-09-01

    With the aim of determining the connection between the indicators of body posture and latent structure of morphological variables in children aged 7 and 8 years, first and second grade of primary school, a set of 17 morphological measures and 12 body posture indicators were longitudinally applied to a sample of 110 boys and 114 girls. The latent structure of morphological variables in both sexes was defined by three factors but at a different order of significance: in boys, the order was longitudinal dimensionality, voluminosity, mass and subcutaneous fat tissue and transverse dimensionality, whereas in girls the order was voluminosity, mass and subcutaneous fat tissue, longitudinal dimensionality and transverse dimensionality. The latent structure of torax body posture indicator was defined by two factors, the status of body posture of the rear part of the thorax, and status of the body posture of the front part of the thorax. The results obtained by canonical correlation analysis between predictive variables, morphological latent structure and criterion variables, latent structure of thorax body posture indicators with two posture indicators of the chest and one of the foot status, showed two important pairs of canonical roots on each measurement, suggesting a significant association between these two sets of parameters.

  20. Clinical value of isotope methods in adrenal morphology investigations

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, W.; Feltynowski, T.; Graban, W. (Akademia Medyczna, Warsaw (Poland))

    1981-01-01

    In the years 1976-1980 in 105 patients 124 adrenal scintigrams were obtained, including 50 in patients with primary hyperaldosteronism syndrome, 27 with Cushings syndrome, 8 after bilateral total adrenalectomy, 4 with adrenal virilizing tumours, 6 with phaeochromocytoma, 10 with normal adrenal function. The results of scintigraphy were compared with those of arteriography, phlebography, computer tomography and postoperative findings. The clinical value of scintigraphy was found to be greatest in cases of adrenocortical disease. In cases of phaeochromocytoma isotope angioscintigraphy is a useful method for localizing the tumour since it makes possible demonstration of the vascular bed of the tumour. A close correlation was demonstrated between the results of scintigraphy and those of computer tomography. In the group of 27 patients treated surgically for adrenocortical disease in 87% of cases an agreement was found between the results of scintigraphy and the result of the operation. For different adrenocortical diseases this per cent was: 77% for Cushings syndrome, 91% for primary hyperaldosteronism, 100% for adrenal virilizing tumours. The study showed that adrenal scintigraphy is a very valuable diagnostic method of high clinical usefulness in adrenocortical diseases.

  1. MORPHOLOGICAL VARIATIONS OF MUSCLE PLANTARIS: ANATOMICAL AND CLINICAL INSIGHT

    Directory of Open Access Journals (Sweden)

    Mohini M Joshi

    2014-10-01

    Full Text Available Background: Plantaris is large muscle in mammals other than primates. Plantaris muscle has long been a subject of much confusion and speculation Evolutionists have speculated on its phylogenetic significance, as a vestigial organ, while surgeons have removed it ‘useless vestige’ to employ its tendon as a spare part for the surgical repair, example tendon transfer operations and reconstruction and as a graft in reconstruction of ligaments etc. In humans it is reduced greatly in size, power, and function and may even be absent. Aim: With this background the aim of the present work is to study morphology, describe the observed variations of the Plantaris muscle, and to discuss the functional significance of Plantaris muscle. Methodology: For the present work 84 limbs available in the department of Anatomy were dissected. The posterior aspect of the knee was dissected using standard surgical equipment and dissection techniques. The Plantaris muscle was isolated and length of fleshy belly and tendon were measured. Any variations in origin, insertion and size were recorded. Result: Mean length of fleshy belly of the Plantaris muscle was 8.39 cm on right side and 8.16 cm on left side. In present study Plantaris muscle was absent 6.66% on right side of the leg; while 12.82 % on left side. In present study variation in insertion of the Plantaris were observed like insertion along medial margin of tendocalcaneus on to calcaneus, in front of tendocalcaneus on to calcaneus, fused to tendocalcaneus and insertion of the Plantaris on deep fascia of leg at the level of ankle. Other variations noted were two bellies of the Plantaris one from lateral supracondylar ridge and other from deep surface of Gastrocnemius, two heads of Plantaris: Both bellies were fused in the lower part producing bipennate arrangement, thin & thick belly of the Plantaris muscle. Variations were also observed in relation to origin that Plantaris muscle originating from deep surface

  2. Cryptosporidium infection in ostriches (Struthio camelus in Brazil: clinical, morphological and molecular studies

    Directory of Open Access Journals (Sweden)

    MMAB Santos

    2005-06-01

    Full Text Available Avian cryptosporidiosis has been reported in more than 30 species of birds. To date, the species infecting birds are C. baileyi, C. galli and C. meleagridis. In this study, the morphological, clinical and molecular characteristics of a Brazilian ostrich isolate of Cryptosporidium are described. The oocysts of this Brazilian isolate are larger and more elongated than those of Cryptosporidium previously reported in ostriches, which were morphologically similar to C. meleagridis. Morphological, biological and molecular analyses demonstrated similarity of this ostrich isolate with C. baileyi, suggesting that there are at least two Cryptosporidium species infecting ostriches; one with molecular, biological and morphological characteristics related to C. baileyi, and another morphologically similar to C. meleagridis.

  3. Whole-Body Clinical Applications of Digital Tomosynthesis.

    Science.gov (United States)

    Machida, Haruhiko; Yuhara, Toshiyuki; Tamura, Mieko; Ishikawa, Takuya; Tate, Etsuko; Ueno, Eiko; Nye, Katelyn; Sabol, John M

    2016-01-01

    With flat-panel detector mammography, radiography, and fluoroscopy systems, digital tomosynthesis (DT) has been recently introduced as an advanced clinical application that removes overlying structures, enhances local tissue separation, and provides depth information about structures of interest by providing high-quality tomographic images. DT images are generated from projection image data, typically using filtered back-projection or iterative reconstruction. These low-dose x-ray projection images are easily and swiftly acquired over a range of angles during a single linear or arc sweep of the x-ray tube assembly. DT is advantageous in a variety of clinical contexts, including breast, chest, head and neck, orthopedic, emergency, and abdominal imaging. Specifically, compared with conventional mammography, radiography, and fluoroscopy, as a result of reduced tissue overlap DT can improve detection of breast cancer, pulmonary nodules, sinonasal mucosal thickening, and bone fractures and delineation of complex anatomic structures such as the ostiomeatal unit, atlantoaxial joint, carpal and tarsal bones, and pancreatobiliary and gastrointestinal tracts. Compared with computed tomography, DT offers reduced radiation exposure, better in-plane resolution to improve assessment of fine bony changes, and less metallic artifact, improving postoperative evaluation of patients with metallic prostheses and osteosynthesis materials. With more flexible patient positioning, DT is also useful for functional, weight-bearing, and stress tests. To optimize patient management, a comprehensive understanding of the clinical applications and limitations of whole-body DT applications is important for improvement of diagnostic quality, workflow, and cost-effectiveness. Online supplemental material is available for this article. (©)RSNA, 2016. PMID:27163590

  4. Clinical and morphological evaluation of tuberculosis peripheral lymphadenopathy

    International Nuclear Information System (INIS)

    Objective: To analyze clinical presentations in patient of tuberculosis peripheral lymphadenopathy. Subjects and Methods: Patients presenting with peripheral lymphadenopathy with the confirmed diagnosis of tuberculosis were included in the study. The diagnosis of tuberculosis was made on finding acid fast bacilli on smear examination and / or histological demonstration of caseating epithelioid cell granulomas in the specimen obtained by fine needle aspiration cytology (FNAC) or excision biopsy. Patients in whom definite diagnosis of tuberculosis was not established on the basis of microscopy or histopathology examination were excluded from the study. History and physical examination findings were recorded on pre-designed proforma. Results: The maximum number of patients (68.75%) was in pediatric age group. The duration of illness was more than a year in 43.75% of the patients. Cervical region was the commonest affected in 70.83% patients. In majority of cases (89.58%) glands were multiple and in 66.7% glands were matted. In 83% cases diagnosis was achieved by FNAC subjected to cytology and acid fast bacilte (AFB) smear examination. Conclusion: In local setting tuberculosis etiology should be strongly suspected in a young patient presenting with peripheral lymphadenopathy, with prolonged duration of illness, and involvement of cervical glands with multiple and matted appearance. FNA is a reliable tool of diagnosis. (author)

  5. Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma.

    Science.gov (United States)

    Skorić, T; Korsić, M; Zarković, K; Plavsić, V; Besenski, N; Breskovac, L; Giljević, Z; Paladino, J

    1999-06-01

    A 41-year-old male presented with progressive visual defects, acromegaly and hyperthyroidism. After clinical evaluation a giant GH/TSH-secreting pituitary adenoma was diagnosed. Administration of the somatostatin analog octreotide at doses of 150 microg s.c. per day inhibited the secretion of both GH and TSH. A three-week treatment with octreotide prior to surgery led to slight visual improvement and CT scan showed some new necrotic areas within the tumor mass. Transcranial surgery was performed. By immunohistochemical analyses of the adenoma tissue GH, prolactin and beta-chorionic gonadotropin were detected; TSH was negative. Electron microscopy revealed an undifferentiated, monomorphous adenoma with morphological features of an acidophil stem cell adenoma such as the presence of misplaced exocytoses, fibrous bodies and mitochondrial gigantism. However, the tumor cells contained small secretory granules (up to 250 nm) accumulated along the cell membrane characteristic of thyrotrope cells. Furthermore, some adenoma cells were fusiform with long cytoplasmic processes resembling thyrotropes. Two months after the operation CT scan revealed a large residual tumor. Serum GH and TSH levels had increased again and the TSH level was even higher than before the treatment. The patient died suddenly, most probably of lethal arrhythmia. Specimens of the adenoma tissue obtained at autopsy confirmed the previous findings with the exception of positive immunostaining for TSH which was found in less than 1% of the adenoma cells. This undifferentiated, monomorphous GH/TSH-secreting pituitary adenoma represents an entity that is unusual both in its ultrastructural features and clinical manifestations suggesting a cytogenesis from an early, undifferentiated stem cell. PMID:10366409

  6. Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma.

    Science.gov (United States)

    Skorić, T; Korsić, M; Zarković, K; Plavsić, V; Besenski, N; Breskovac, L; Giljević, Z; Paladino, J

    1999-06-01

    A 41-year-old male presented with progressive visual defects, acromegaly and hyperthyroidism. After clinical evaluation a giant GH/TSH-secreting pituitary adenoma was diagnosed. Administration of the somatostatin analog octreotide at doses of 150 microg s.c. per day inhibited the secretion of both GH and TSH. A three-week treatment with octreotide prior to surgery led to slight visual improvement and CT scan showed some new necrotic areas within the tumor mass. Transcranial surgery was performed. By immunohistochemical analyses of the adenoma tissue GH, prolactin and beta-chorionic gonadotropin were detected; TSH was negative. Electron microscopy revealed an undifferentiated, monomorphous adenoma with morphological features of an acidophil stem cell adenoma such as the presence of misplaced exocytoses, fibrous bodies and mitochondrial gigantism. However, the tumor cells contained small secretory granules (up to 250 nm) accumulated along the cell membrane characteristic of thyrotrope cells. Furthermore, some adenoma cells were fusiform with long cytoplasmic processes resembling thyrotropes. Two months after the operation CT scan revealed a large residual tumor. Serum GH and TSH levels had increased again and the TSH level was even higher than before the treatment. The patient died suddenly, most probably of lethal arrhythmia. Specimens of the adenoma tissue obtained at autopsy confirmed the previous findings with the exception of positive immunostaining for TSH which was found in less than 1% of the adenoma cells. This undifferentiated, monomorphous GH/TSH-secreting pituitary adenoma represents an entity that is unusual both in its ultrastructural features and clinical manifestations suggesting a cytogenesis from an early, undifferentiated stem cell.

  7. MORPHOLOGICAL STUDY ON LUMBOSACRAL TRANSITIONAL VERTEBRA IN ADULT INDIAN SACRA AND ITS CLINICAL IMPLICATIONS

    Directory of Open Access Journals (Sweden)

    Kosuri Kalyan Chakravarthi

    2013-12-01

    Full Text Available Lumbosacral transitional vertebra (Sacralization is the fusion of 5Th lumber vertebra with the first segment of the sacrum it may be complete or incomplete. In complete sacralization body of the 5Th lumber vertebra completely fuses with the sacrum, where as in incomplete sacralisation shows a well defined joint line between the transverse process and the sacrum. Both forms may be either unilateral or bilateral. Such kind of abnormalities are importance while reporting the X ray, CT and MRI films, during surgical procedures at the Lumbosacral region and making a differential diagnosis for the low back ache patients. Accordingly the present study was designed to evaluate the incidence and morphological study of Sacralization (Lumbosacral transitional vertebra in adult Indian sacra and its clinical significance. This study was carried out on 150 dry human sacra irrespective of age and sex at Mayo Institute of Medical Sciences- Barabanki,-UP, Melaka Manipal Medical College-Manipal University and Department of Anatomy, KMCT Medical College, Manassery-Calicut. It was observed that out of 150 sacra, 57 (38% sacra showed sacralization. Out of 57 sacralized bones, 38 (25.33% bones showed bilateral sacralization, whereas 19 (12.67% bones showed unilateral sacralization. Such Lumbosacral transitional vertebra may increase the ricks of Disc bulge / herniation or pseudarthrosis (nonunions with the ilium, degenerative sclerosis around the false joint, compression of lumber nerve roots, low back pain, and false administration of epidural or intradural anaesthetics in lumbosacral region. Its sound knowledge is not only enlightening for the orthopaedic surgeons, also vital for the clinical anatomists, forensic experts and morphologists

  8. CLINICAL-MORPHOLOGICAL CORRELATIONS IN ADVANCED COLORECTAL CANCER

    Directory of Open Access Journals (Sweden)

    Gh. Bălan

    2011-11-01

    Full Text Available Background: During 2000-2007 we have selected and supervised a lot of 279 cases operated for colorectal cancer in Clinic no.1 Surgery from “St. Spiridon” Hospital. The sex repartition during the entire study period shows the preponderance of male cases (61.29% in comparison to the female cases of 38.7 %. In our study the operated colorectal carcinomas have a higher incidence at patients over 60 years old, 71.67%. There is as well a higher percent for the age group 60-70 years old and 70-80 years old which percent reaches 34.76% respectively 32.97% out of the total number of cases. When comparing the average age of the two analyzed lots there we can notice that the average age of the female patients does not differ significantly from the age of the male patients. The average age of the female patients was of 64,3±8,58 with minimum values of 51 years and maximum of 78 years and the average age of male patients was of 67,9±10,5 with minim of 44 years and maximum of 86 years. The on segments distribution of the colorectal cancer is presented as follows: rectum 108 cases (38,7%, sigmoid 96 cases (34,40%, descendent 19 cases (6,81%, hepatic angle 17 cases (6.09%, transverse 17 cases (6.09%, ascending 12 cases (4,3% % the rest of the localizations being in a smaller number. In the case of males the colorectal cancer is met most often at the level of the rectum (32.74% and the case of females at the level of the sigmoid (41.66%. Regarding the microscopic results they were: well differentiated adenocarcinoma 45.83%, moderate differentiated 43.75% and weak differentiated 10.42%. The Chi-square analysis shows that there is no association between the macroscopic aspects of the tumours and their histological aspect. Analyzing the microscopic aspect according to the location of the tumour there is observed that 86.95% of the tumours that were located at the level of the rectum have a vegetative aspect. There was not observed any link between the gender

  9. Clinical and neuroimage findings of dementia with lewy bodies

    International Nuclear Information System (INIS)

    Dementia with lewy bodies (DLB) is the second common degenerative dementia and has several characteristics including fluctuating cognition, visual hallucination and Parkinsonism. We investigated clinical manifestations and neuroimaging findings in DLB patients. Ten probable DLB patients were included in this study. Brain MRI, Tc-99m HMPAO brain perfusion SPECT and I-123 IPT SPECT were performed. All patients were men and mean age of onset was 64.2 years (range from 54 to 80). All had fluctuating cognition and Parkinsonism, and 8 had visual hallucination. Dementia preceded Parkinsonism in 3 patients. Fluctuation of K-MMSE ranges from 3 to 8 points. Rest tremor was seen in 5 patients. Brain MRI showed cortical atrophy in all patients. Tc-99m brain perfusion SPECT showed hypoperfusion in occipital area as well as fronto-temporo-parietal areas. I-123 IPT SPECT revealed reduced uptake comparable to Parkinson's disease in the striatum. DLB should be first considered as one of possible diagnosis in patients showing dementia in the early stage of Parkinsonism. Hypoperfusion in the occipital area was thought to be a characteristic finding in DLB and to be helpful in differentiating DLB from other degenerative dementias

  10. A Dynamic Imaging Database for 3-D Morphologic Analysis and Clinical Assessment in Diagnostic Radiology

    OpenAIRE

    Niculescu, Gabriela; Toni, Louay; Foran, David J.; Nosher, John L.; DeMarco, J. Kevin

    2002-01-01

    Modern imaging techniques such as MRI and CT have become invaluable clinical and research tools for visualizing internal organs and anatomic structures, non-invasively. We present a dynamic imaging database for performing comparative morphologic studies in diagnostic radiology to facilitate clinical assessment. The prototype system utilizes a double elliptic Fourier transform to characterize shape in three dimensions. A prototype system was used to evaluate neuroanatomy from MR brain scans of...

  11. Clinical outcome and morphologic determinants of mural thrombus in abdominal aortic endografts

    NARCIS (Netherlands)

    N.F. Oliveira (N.); F.M.V. Bastos Gonçalves (Frederico); S.E. Hoeks (Sanne); S. ten Raa (Sander); K.H.J. Ultee (Klaas); E.V. Rouwet (Ellen); J.M. Hendriks (Joke); H.J.M. Verhagen (Hence)

    2015-01-01

    textabstractObjective Endograft mural thrombus has been associated with stent graft or limb thrombosis after endovascular aneurysm repair (EVAR). This study aimed to identify clinical and morphologic determinants of endograft mural thrombus accumulation and its influence on thromboembolic events aft

  12. Verb Morphology as Clinical Marker of Specific Language Impairment: Evidence from First and Second Language Learners

    Science.gov (United States)

    Verhoeven, Ludo; Steenge, Judit; van Balkom, Hans

    2011-01-01

    The goal of this study was to search for verb morphology characteristics as possible clinical markers of SLI in Dutch as a first and second language. We also wanted to find out to what extent bilingual children with SLI are additionally disadvantaged in comparison to monolingual children with SLI, on the one hand, and to typically developing…

  13. A Review of Body Dysmorphic Disorder and Its Presentation in Different Clinical Settings

    OpenAIRE

    Mufaddel, Amir; Osman, Ossama T.; Almugaddam, Fadwa; Jafferany, Mohammad

    2013-01-01

    Objective: Body dysmorphic disorder (BDD) is a relatively common psychiatric disorder characterized by preoccupations with perceived defects in physical appearance. This review aimed to explore epidemiology, clinical features, comorbidities, and treatment options for BDD in different clinical settings.

  14. Modeling a radiotherapy clinical procedure: total body irradiation.

    Science.gov (United States)

    Esteban, Ernesto P; García, Camille; De La Rosa, Verónica

    2010-09-01

    Leukemia, non-Hodgkin's lymphoma, and neuroblastoma patients prior to bone marrow transplants may be subject to a clinical radiotherapy procedure called total body irradiation (TBI). To mimic a TBI procedure, we modified the Jones model of bone marrow radiation cell kinetics by adding mutant and cancerous cell compartments. The modified Jones model is mathematically described by a set of n + 4 differential equations, where n is the number of mutations before a normal cell becomes a cancerous cell. Assuming a standard TBI radiotherapy treatment with a total dose of 1320 cGy fractionated over four days, two cases were considered. In the first, repopulation and sub-lethal repair in the different cell populations were not taken into account (model I). In this case, the proposed modified Jones model could be solved in a closed form. In the second, repopulation and sub-lethal repair were considered, and thus, we found that the modified Jones model could only be solved numerically (model II). After a numerical and graphical analysis, we concluded that the expected results of TBI treatment can be mimicked using model I. Model II can also be used, provided the cancer repopulation factor is less than the normal cell repopulation factor. However, model I has fewer free parameters compared to model II. In either case, our results are in agreement that the standard dose fractionated over four days, with two irradiations each day, provides the needed conditioning treatment prior to bone marrow transplant. Partial support for this research was supplied by the NIH-RISE program, the LSAMP-Puerto Rico program, and the University of Puerto Rico-Humacao.

  15. Relationship Between Beak Morphological Variables and Body Size and Mantle Length of Male and Female Argentine Shortfin Squid (Illex argentinus)

    Institute of Scientific and Technical Information of China (English)

    CHEN Xinjun; LU Huajie; LIU Bilin; FANG Zhou

    2012-01-01

    Beak of cephalopod is an important hard tissue.Understanding the morphology of beak can yield critical information on the role of cephalopods in the ecosystem.The south patagonic stock of the Argentine shortfin squid,Illex argentinus,is not only one of the most important fishing targets,but also one of the most important species in the marine eco-system of the southwest Atlantic.A total of 430 samples of I.argentinus,including 229 females 103-346mm in mantle length (ML) and 201males 140-298mm in ML,were collected from the area off the Exclusive Economic Zone of Argentinean waters by Chinese squid jigging vessels during February to May 2007.The morphology of their beaks was evaluated.The relationships between beak morphological variables and ML differed significantly among males and females.They could be best described by logarithmic functions for females and linear functions for males except for upper wing length (UWL) and lower rostrum length (LRL),which followed exponential functions in their relationships with ML.The results showed the sexual dimorphism in the relationship between ML and beak morphology for the south patagonic stock of I.argentinus.However,no significant difference was found between males and females in the relationships of beak morphological variables (except for UWL) versus body weight (BW),suggesting that the relationship between beak morphological variables and BW can be used for estimating the biomass consumed by their predators.

  16. Analysis of clinical and morphological parameters in patients with vulvar melanoma

    Directory of Open Access Journals (Sweden)

    E. V. Korzhevskaya

    2011-01-01

    Full Text Available The purpose of this study was to estimate the value of and to reveal the specific features of clinical and morphological parameters in pa- tients with vulvar melanoma. The study was based on the data obtained from the analysis of 40 vulvar melanoma patients treated at the N.N. Blokhin Russian Cancer Research Institute in the period January 1980 to December 2010.

  17. ERP in chronic pancreatitis - ductal morphology, relation to exocrine function and pain - clinical value

    International Nuclear Information System (INIS)

    ERP was analyzed in 87 patients with chronic pancreatitis with special reference to its clinical value in management of pain, the dominating symptom in uncomplicated chronic pancreatitis. A significant correlation was found between ductal changes due to pancreatitis and decrease in pancreatic function. However, no association was found between severe pancreatic pain and pancreatic function or pancreatic morphology. The significance of ERP in management of patients with persistent severe pancreatic pain is discussed. (orig.)

  18. Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology

    Science.gov (United States)

    Wu, Pei-Hsun; Hung, Shen-Hsiu; Ren, Tina; Shih, Ie-Ming; Tseng, Yiider

    2011-02-01

    NAC1, a BTB/POZ family member, has been suggested to participate in maintaining the stemness of embryonic stem cells and has been implicated in the pathogenesis of human cancer. In ovarian cancer, NAC1 upregulation is associated with disease aggressiveness and with the development of chemoresistance. Like other BTB/POZ proteins, NAC1 forms discrete nuclear bodies in non-dividing cells. To investigate the biological role of NAC1 nuclear bodies, we characterized the expression dynamics of NAC1 nuclear bodies during different phases of the cell cycle. Fluorescence recovery after photobleaching assays revealed that NAC1 was rapidly exchanged between the nucleoplasm and NAC1 nuclear bodies in interphase cells. The number of NAC1 bodies significantly increased and their size decreased in the S phase as compared to the G0/G1 and G2 phases. NAC1 nuclear bodies disappeared and NAC1 became diffuse during mitosis. NAC1 nuclear bodies reappeared immediately after completion of mitosis. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis.

  19. Allometry and size control: what can studies of body size regulation teach us about the evolution of morphological scaling relationships?

    Science.gov (United States)

    Mirth, Christen K; Anthony Frankino, W; Shingleton, Alexander W

    2016-02-01

    The relationship between organ and body size, known as morphological allometry, has fascinated biologists for over a century because changes in allometry generate the vast diversity of organism shapes. Nevertheless, progress has been limited in understanding the genetic mechanisms that regulate allometries and how these mechanisms evolve. This is perhaps because allometry is measured at the population level, however adult organ and body size depends on genetic background and the developmental environment of individuals. Recent findings have enhanced our understanding of how insects regulate their organ and body sizes in response to environmental conditions, particularly nutritional availability. We argue that merging these developmental insights with a population genetics approach will provide a powerful system for understanding the evolution of allometry. PMID:27436558

  20. From lizard body form to serpentiform morphology: The atlas-axis complex in African cordyliformes and their relatives.

    Science.gov (United States)

    Čerňanský, Andrej

    2016-04-01

    The comparative vertebral morphology of the atlas-axis complex in cordyliforms, xantusiid and several skinks is studied here. These lizards are particularly interesting because of their different ecological adaptations and anti-predation strategies, where conformation ranges from the lizard-like body to a snake-like body. This transition to serpentiform morphology shows several evolutionary patterns in the atlas-axis complex: 1) the zygapophyseal articulations are lost in the early stage of the transition. In contrast to mammals, the atlas is more or less locked to the axis in lepidosaurs, but the absence of zygapophyseal articulation releases this locking for rotation. However despite its serpentiform morphology, Chamaesaura is different, in possessing this articulation; 2) the first intercentrum of Chamaesaura and Tetradactylus africanus (serpentiform grass-swimmers) is fully curved anteriorly, underlying the occipital condyle. While this limits ventral skull rotation beyond a certain angle, it locks the skull, which is a crucial adaptation for a sit-and-wait position in grassland habitats that needs to keep the head stabilized; and 3) in Acontias, most of the atlas articular surface with the occipital condyle is formed by the lateral aspect of the articulation area relative to the area located in the dorsal region of the slightly reduced intercentrum. A similar state occurs in amphisbaenians, most likely reflecting a fossorial lifestyle of the limbless lizards. Although Chamaesaura and Tetradactylus live sympatrically in grasslands, Chamaesaura differs in several ways in atlas-axis complex: for example, aforementioned presence of the atlas-axis zygapophyseal articulation, and long posterodorsal processes. Its occipital condyle protrudes further posteriorly, placing the atlas-axis complex further from the endocranium than in Tetradactylus. Hence, adaptation in the same niche, even among sister clades, can lead to different atlas-axis morphology due to different

  1. Angioimmunoblastic T-Cell lymphoma: A critical analysis of clinical, morphologic and immunophenotypic features

    Directory of Open Access Journals (Sweden)

    Bal Munita

    2010-10-01

    Full Text Available Background: Angioimmunoblastic T-cell lymphoma (AITL, a subtype of peripheral T-cell lymphoma (PTCL, is characterized by unique clinical and biological features. Its diagnosis remains a challenge as clinical presentation as well as pathologic findings are frequently misleading. Material and Methods: We retrospectively analyzed the clinical, morphological and immunophenotypic spectrum of 17 cases of histologically proven AITL. Result: The mean age was 54 years and male to female ratio was 2.4. Common clinical features included generalized lymphadenopathy (60%, hepatomegaly (70%, splenomegaly (50%, anemia (80% and polyclonal hypergammaglobulinemia (100%. Microscopically, three architectural patterns; pattern I (6%, pattern II (41% and pattern III (53% were observed. Bone marrow infiltration was seen in 60% cases and 30% cases revealed plasmacytosis. Absence of follicles, polymorphous infiltrate, extra-follicular follicular dendritic cell (FDC proliferation, high endothelial venules (HEV prominence and neoplastic T-cells were the diagnostic features of AITL. CD10 positivity (47%, clear cells in the background (59% admixture with large size CD20+ B-immunoblasts (35% and bone marrow plasmacytosis (50% were common observations. Conclusion: Awareness of various morphological and immunophenotypic complexities of AITL and distinction from reactive adenopathies and other types of lymphomas that mimic AITL is underscored in this study.

  2. Illusory changes in body size modulate body satisfaction in a way that is related to non-clinical eating disorder psychopathology.

    Directory of Open Access Journals (Sweden)

    Catherine Preston

    Full Text Available Historically, body size overestimation has been linked to abnormal levels of body dissatisfaction found in eating disorders. However, recently this relationship has been called into question. Indeed, despite a link between how we perceive and how we feel about our body seeming intuitive, until now lack of an experimental method to manipulate body size has meant that a causal link, even in healthy participants, has remained elusive. Recent developments in body perception research demonstrate that the perceptual experience of the body can be readily manipulated using multisensory illusions. The current study exploits such illusions to modulate perceived body size in an attempt to influence body satisfaction. Participants were presented with stereoscopic video images of slimmer and wider mannequin bodies viewed through head-mounted displays from first person perspective. Illusory ownership was induced by synchronously stroking the seen mannequin body with the unseen real body. Pre and post-illusion affective and perceptual measures captured changes in perceived body size and body satisfaction. Illusory ownership of a slimmer body resulted in participants perceiving their actual body as slimmer and giving higher ratings of body satisfaction demonstrating a direct link between perceptual and affective body representations. Change in body satisfaction following illusory ownership of a wider body, however, was related to degree of (non-clinical eating disorder psychopathology, which can be linked to fluctuating body representations found in clinical samples. The results suggest that body perception is linked to body satisfaction and may be of importance for eating disorder symptomology.

  3. Illusory changes in body size modulate body satisfaction in a way that is related to non-clinical eating disorder psychopathology.

    Science.gov (United States)

    Preston, Catherine; Ehrsson, H Henrik

    2014-01-01

    Historically, body size overestimation has been linked to abnormal levels of body dissatisfaction found in eating disorders. However, recently this relationship has been called into question. Indeed, despite a link between how we perceive and how we feel about our body seeming intuitive, until now lack of an experimental method to manipulate body size has meant that a causal link, even in healthy participants, has remained elusive. Recent developments in body perception research demonstrate that the perceptual experience of the body can be readily manipulated using multisensory illusions. The current study exploits such illusions to modulate perceived body size in an attempt to influence body satisfaction. Participants were presented with stereoscopic video images of slimmer and wider mannequin bodies viewed through head-mounted displays from first person perspective. Illusory ownership was induced by synchronously stroking the seen mannequin body with the unseen real body. Pre and post-illusion affective and perceptual measures captured changes in perceived body size and body satisfaction. Illusory ownership of a slimmer body resulted in participants perceiving their actual body as slimmer and giving higher ratings of body satisfaction demonstrating a direct link between perceptual and affective body representations. Change in body satisfaction following illusory ownership of a wider body, however, was related to degree of (non-clinical) eating disorder psychopathology, which can be linked to fluctuating body representations found in clinical samples. The results suggest that body perception is linked to body satisfaction and may be of importance for eating disorder symptomology. PMID:24465698

  4. Deformable registration for image-guided spine surgery: preserving rigid body vertebral morphology in free-form transformations

    Science.gov (United States)

    Reaungamornrat, S.; Wang, A. S.; Uneri, A.; Otake, Y.; Zhao, Z.; Khanna, A. J.; Siewerdsen, J. H.

    2014-03-01

    Purpose: Deformable registration of preoperative and intraoperative images facilitates accurate localization of target and critical anatomy in image-guided spine surgery. However, conventional deformable registration fails to preserve the morphology of rigid bone anatomy and can impart distortions that confound high-precision intervention. We propose a constrained registration method that preserves rigid morphology while allowing deformation of surrounding soft tissues. Method: The registration method aligns preoperative 3D CT to intraoperative cone-beam CT (CBCT) using free-form deformation (FFD) with penalties on rigid body motion imposed according to a simple intensity threshold. The penalties enforced 3 properties of a rigid transformation - namely, constraints on affinity (AC), orthogonality (OC), and properness (PC). The method also incorporated an injectivity constraint (IC) to preserve topology. Physical experiments (involving phantoms, an ovine spine, and a human cadaver) as well as digital simulations were performed to evaluate the sensitivity to registration parameters, preservation of rigid body morphology, and overall registration accuracy of constrained FFD in comparison to conventional unconstrained FFD (denoted uFFD) and Demons registration. Result: FFD with orthogonality and injectivity constraints (denoted FFD+OC+IC) demonstrated improved performance compared to uFFD and Demons. Affinity and properness constraints offered little or no additional improvement. The FFD+OC+IC method preserved rigid body morphology at near-ideal values of zero dilatation (D = 0.05, compared to 0.39 and 0.56 for uFFD and Demons, respectively) and shear (S = 0.08, compared to 0.36 and 0.44 for uFFD and Demons, respectively). Target registration error (TRE) was similarly improved for FFD+OC+IC (0.7 mm), compared to 1.4 and 1.8 mm for uFFD and Demons. Results were validated in human cadaver studies using CT and CBCT images, with FFD+OC+IC providing excellent preservation

  5. Anatomy of the cardiac nervous system with clinical and comparative morphological implications.

    Science.gov (United States)

    Kawashima, Tomokazu

    2011-03-01

    Unlike autonomic nervous preservation in other surgeries for improving patient quality of life, autonomic cardiac nervous system (ACNS) preservation has been neglected in cardiovascular surgery because of technical difficulties and other unsolved issues. Because such ACNS preservation in cardiovascular surgery is anticipated in the future, detailed anatomical investigation of the human ACNS is required. Therefore, we have conducted morphological studies of the ACNS from macroscopic, clinical, and evolutionary anatomical viewpoints. In this study, I review detailed anatomical studies of the human ACNS together with their clinical implications. In addition, the evolutionary comparative anatomical significance of primate ACNS is also summarized to help understand and translate the findings of functional experiments to humans. These integrated findings will be the subject of a future study unifying molecular embryological and anatomical findings to clarify cardiac functions based on functional animal experiments, clinical applications such as improving surgery techniques and individual order-made surgery in cardiac surgery, and for future evaluation in regenerative medicine. PMID:21116884

  6. Body composition : methods of measurement, normative values and clinical use

    OpenAIRE

    Genton Graf, Laurence

    2011-01-01

    Measurement of body composition is an important part of nutritional assessment. The low FFM associated with malnutrition has been associated with numerous infectious and noninfectious complications, increasing length of stay, morbidity and mortality. DXA and TBK are reference method for determination of FFM and BCM, but, as these methods are expensive and require extensive technique of the operator, we have focused especially on BIA, an easy, quick, safe and reliable bedside method to measure...

  7. Clinical and morphological evaluation of snake venom derived fibrin glue on the tendon healing in dogs

    Directory of Open Access Journals (Sweden)

    G. C. Ferraro

    2005-12-01

    Full Text Available The aim of this study was to evaluate the effect of snake venom derived fibrin glue on the healing of the deep digital flexor tendon, during three periods. The tendon of the 2nd digit of 30 thoracic limbs of dogs was partially sectioned for glue application. Biopsies were performed 7, 15, and 30 days post surgery for the clinical and morphological study of tendons. Analysis of the results showed that 73.3% of the tendons showed stump retraction and 16.6% moderate to excessive adherence, which affected sliding. There was a significant difference in the number of inflammatory cells among the three studied periods, being the highest on day 15. The morphological analysis revealed a typical tendon healing process with a lower level of inflammation in the acute phase, facilitating the cicatricial maturation phase. Snake venom derived fibrin glue promotes the healing in dog flexor tendon.

  8. Developmental quantitative genetic analysis of body weights and morphological traits in the turbot, Scophthalmusmaximus

    Institute of Scientific and Technical Information of China (English)

    WANG Xinan; MA Aijun; MA Deyou

    2015-01-01

    In order to elucidate the genetic mechanism of growth traits in turbot during ontogeny, developmental genetic analysis of the body weights, total lengths, standard lengths and body heights of turbots was conducted by mixed genetic models with additive-dominance effects, based on complete diallel crosses with four different strains of Scophthalmus maximus from Denmark, Norway, Britain, and France. Unconditional genetic analysis revealed that the unconditional additive effects for the four traits were more significant than unconditional dominance effects, meanwhile, the alternative expressions were also observed between the additive and dominant effects for body weights, total lengths and standard lengths. Conditional analysis showed that the developmental periods with active gene expression for body weights, total lengths, standard lengths and body heights were 15–18, 15 and 21–24, 15 and 24, and 21 and 27 months of age, respectively. The proportions of unconditional/conditional variances indicated that the narrow-sense heritabilities of body weights, total lengths and standard lengths were all increased systematically. The accumulative effects of genes controlling the four quantitative traits were mainly additive effects, suggesting that the selection is more efficient for the genetic improvement of turbots. The conditional genetic procedure is a useful tool to understand the expression of genes controlling developmental quantitative traits at a specific developmental period (t-1→t) during ontogeny. It is also important to determine the appropriate developmental period (t-1→t) for trait measurement in developmental quantitative genetic analysis in fish.

  9. Length and volume of morphologically normal kidneys in Korean Children: Ultrasound measurement and estimation using body size

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jun Hwee; Kim, Myung Joon; Lim, Sok Hwan; Lee, Mi Jung [Dept. of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Ji Eun [Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2013-08-15

    To evaluate the relationship between anthropometric measurements and renal length and volume measured with ultrasound in Korean children who have morphologically normal kidneys, and to create simple equations to estimate the renal sizes using the anthropometric measurements. We examined 794 Korean children under 18 years of age including a total of 394 boys and 400 girls without renal problems. The maximum renal length (L) (cm), orthogonal anterior-posterior diameter (D) (cm) and width (W) (cm) of each kidney were measured on ultrasound. Kidney volume was calculated as 0.523 x L x D x W (cm{sup 3}). Anthropometric indices including height (cm), weight (kg) and body mass index (m{sup 2}/kg) were collected through a medical record review. We used linear regression analysis to create simple equations to estimate the renal length and the volume with those anthropometric indices that were mostly correlated with the US-measured renal sizes. Renal length showed the strongest significant correlation with patient height (R2, 0.874 and 0.875 for the right and left kidneys, respectively, p < 0.001). Renal volume showed the strongest significant correlation with patient weight (R2, 0.842 and 0.854 for the right and left kidneys, respectively, p < 0.001). The following equations were developed to describe these relationships with an estimated 95% range of renal length and volume (R2, 0.826-0.884, p < 0.001): renal length = 2.383 + 0.045 x Height (± 1.135) and = 2.374 + 0.047 x Height (± 1.173) for the right and left kidneys, respectively; and renal volume 7.941 + 1.246 x Weight (± 15.920) and = 7.303 + 1.532 x Weight (± 18.704) for the right and left kidneys, respectively. Scatter plots between height and renal length and between weight and renal volume have been established from Korean children and simple equations between them have been developed for use in clinical practice.

  10. Ovarian cancer cell line panel (OCCP: clinical importance of in vitro morphological subtypes.

    Directory of Open Access Journals (Sweden)

    Corine M Beaufort

    Full Text Available Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed characterization of in vitro models representing the different histological and molecular ovarian cancer subtypes is critical to enable reliable preclinical testing. There are approximately 100 publicly available ovarian cancer cell lines but their cellular and molecular characteristics are largely undescribed. We have characterized 39 ovarian cancer cell lines under uniform conditions for growth characteristics, mRNA/microRNA expression, exon sequencing, drug response for clinically-relevant therapeutics and collated all available information on the original clinical features and site of origin. We tested for statistical associations between the cellular and molecular features of the lines and clinical features. Of the 39 ovarian cancer cell lines, 14 were assigned as high-grade serous, four serous-type, one low-grade serous and 20 non-serous type. Three morphological subtypes: Epithelial (n = 21, Round (n = 7 and Spindle (n = 12 were identified that showed distinct biological and molecular characteristics, including overexpression of cell movement and migration-associated genes in the Spindle subtype. Comparison with the original clinical data showed association of the spindle-like tumours with metastasis, advanced stage, suboptimal debulking and poor prognosis. In addition, the expression profiles of Spindle, Round and Epithelial morphologies clustered with the previously described C1-stromal, C5-mesenchymal and C4 ovarian subtype expression profiles respectively. Comprehensive profiling of 39 ovarian cancer cell lines under controlled, uniform conditions demonstrates clinically relevant cellular and genomic characteristics. This data provides a rational basis for selecting models to develop

  11. Associations between craniofacial morphology, head posture, and cervical vertebral body fusions in men with sleep apnea

    DEFF Research Database (Denmark)

    Svanholt, Palle; Petri, Niels; Wildschiødtz, Gordon;

    2009-01-01

    INTRODUCTION: The aim of this study was to analyze craniofacial profiles and head posture in patients with obstructive sleep apnea (OSA) subgrouped according to cervical column morphology. METHODS: Seventy-four white men aged 27 to 65 years (mean, 49.0 years) diagnosed with OSA in sleep studies...... dimensions between the groups were assessed by unpaired t tests. RESULTS: No significant differences were seen between groups I and III. Between groups I and II, significant differences were seen in jaw relationship (P

  12. Nodal colloid goiter: clinical and morphological criteria of thyroid autonomy and progressive growth

    Directory of Open Access Journals (Sweden)

    S S Antonova

    2006-03-01

    Full Text Available Goal. To work up clinical and morphological criteria of thyroid authonomy and progressive growth in nodal colloid goiter (NCG. Methods. A group of patients with nodal euthyroid goiter (NEG (40 patients and a group of patients with nodular toxic goiter (NTG (40 patients were formed to compare clinical and morphological criteria of NCG growth to/with development of functional autonomy (FA. All patients were conducted research including physical examination, thyroid palpation, ultrasound, blood level of TSH and T4, scintigraphy, aspiration (needle biopsy, immunocytological and immunohistological reactions and statistics. In the study the method of indirect immunoperoxidase reaction with monoclonal rat/mouse antigens to Ki-67, TSH, galectin-3, Apo-test (“Dako Corporation”, “Novocastra Laboratories Ltd.” was used. Results. 1. In NEG expression of cell proliferation marker Ki-67 for certain rises pro rata to increase of proliferation degree, and in NTG grows according to FA development. 2. Apoptosis expression in NEG decreases according to degree of thyrocytes in a nodule, but in NTG falls pro rata to accumulation of thyroid FA. 3. Positive reaction for TSH in NEG tissue was found in 100%, whereas negative reaction for this receptor in NTG tissue was observed in 81% of all cases. 4. Galectin-3 was expressed in focuses of severe dysplasia of thyroid nodes tissue comparable to galectin-3 expression in the tissue of high-grade differentiated adenocarcinomas. Summary/conclusion. 1. Severe and moderate expression of Ki-67 and mild or negative immunomorphological reaction for Apo-test allows to refer such kinds of nodules to fast-growing/rapid-growing ones. 2. Reliable negative expression TSH receptor in the tissue of NCG is evidence of FA development and is an indication for a treatment of radioactive iodine or for an operation. 3. Galectin-3 probably is an early marker of malignant transformation in thyroid tissue. 4. Having conducted complex

  13. Evaluating the Role of First Polar Body Morphology on Rates of Fertilization and Embryo Development in ICSI Cycles

    Directory of Open Access Journals (Sweden)

    Iman Halvaei

    2011-01-01

    Full Text Available Background: Recent studies have demonstrated that morphology of the first polar body (1st PBis related to oocyte viability, which can be used as a prognostic tool to predict oocyte performanceand pregnancy outcomes in an intracytoplasmic sperm injection (ICSI program. According to somestudies, there is a correlation between oocyte performance and 1st PB morphology, while others havenot reported any correlation. The objective of this study is to evaluate the role of 1st PB morphologyon rates of fertilization and embryo development in ICSI cases.Materials and Methods: In this prospective study morphological characteristics of 470 metaphaseII (MII oocytes were assessed in 80 ICSI cycles. The women were ages 21-42 years (mean 32.6 ±0.2. Their oocytes were retrieved after a hyperstimulation protocol. After denudation, all oocyteswere evaluated for 1st PB morphology. The oocytes were divided into two groups of A (normal 1stPB and B (abnormal fragmented 1st PB. In addition, other abnormalities, such as refractile bodies(RF, wide previtelline space (wPVS, central and general granulation, bull’s eye, vacuole, smoothendoplasmic reticulum cluster (SERc, debris in PVS, shape and dark oocyte were checked. Forverifying of fertilization, about 18-19 hours post-ICSI, oocytes were checked for two-pronuclear.Assessments of embryo quality, development and embryo transfer were done at day two. Chisquare,Fisher’s exact and independent sample t tests were chosen for statistical analysis.Results: Twenty-seven percent of oocytes had fragmented 1st PB, while the remainder was associatedwith other morphological abnormalities. A total of 46.1% and 26.9% of oocytes showed double andmultiple defects, respectively. RF was the most common abnormality observed in group B. Nosignificant differences in women’s’ ages between groups A and B were noted (p=0.3. A total of 179and 107 oocytes (61.5% vs. 59.8% were fertilized in groups A and B, respectively (p=0.7. Therates of

  14. Whole-body MR imaging. Practical issues, clinical applications, and future directions.

    Science.gov (United States)

    Eustace, S J; Walker, R; Blake, M; Yucel, E K

    1999-05-01

    Whole-body MR imaging is in evolution, and although accepting and recognizing limitations, it is likely that both technique and incurred acquisition times will shorten over the next decade. Although the development of dedicated whole-body MR scanners appears to offer the greatest promise for the future, the development of moving table tops, optimized pulse sequences, and advances in gradient technology now facilitate practical whole-body MR imaging using existing clinical systems.

  15. Body composition and morphological assessment of nutritional status in adults: a review of anthropometric variables.

    Science.gov (United States)

    Madden, A M; Smith, S

    2016-02-01

    Evaluation of body composition is an important part of assessing nutritional status and provides prognostically useful data and an opportunity to monitor the effects of nutrition-related disease progression and nutritional intervention. The aim of this narrative review is to critically evaluate body composition methodology in adults, focusing on anthropometric variables. The variables considered include height, weight, body mass index and alternative indices, trunk measurements (waist and hip circumferences and sagittal abdominal diameter) and limb measurements (mid-upper arm and calf circumferences) and skinfold thickness. The importance of adhering to a defined measurement protocol, checking measurement error and the need to interpret measurements using appropriate population-specific cut-off values to identify health risks were highlighted. Selecting the optimum method for assessing body composition using anthropometry depends on the purpose (i.e. evaluating obesity or undernutrition) and requires practitioners to have a good understanding of both practical and theoretical limitations and to be able to interpret the results wisely.

  16. Giant cell tumor of bone: current review of morphological, clinical, radiological, and therapeutic characteristics

    Directory of Open Access Journals (Sweden)

    Georgi P. Georgiev

    2014-09-01

    Full Text Available Giant cell tumor of bone accounts for about 5% of all primary bone tumors in adults and is still one of the most obscure and intensively examined tumors of bone. This largely results from the lack of uniform clinical, radiographic, histological or morphological aspects that allow prediction of recurrence. Classified by the World Health Organization as “an aggressive, potentially malignant lesion”, the giant cell tumor of bone could give lung metastases, could undergo malignant degeneration or could have multicentric localization. It usually develops in long bones but can also occur in unusual locations. The common presenting symptom is increasing pain at the tumor site. Standard treatment ranges from curettage to wide resection, with reports of varying oncological and functional results. The recurrence rate is high during the first 2-3 years after surgery regardless of pre-operative tumor stage. Herein, we discuss the morphological, clinical, radiological, and therapeutic characteristics of this pathologic entity as well as its differential diagnosis. J Clin Exp Invest 2014; 5 (3: 475-485

  17. [Morphological tissue changes after the implantation of elastic lamellar foreign bodies in the experiment].

    Science.gov (United States)

    Maĭborodin, I V; Shevela, A I; Matveeva, V A; Drovosekov, M N; Barannik, M I; Kuznetsova, I V

    2012-01-01

    The reaction of rat tissues was studied using the methods of light microscopy 4, 12, 18 days, 1, 2, 6 and 12 months after hypodermic implantation of polymeric films made of polyhydroxyalkanoates (PHA). It was found that polymer, like any foreign matter in an organism, become immediately covered by fibrin. By day 4, there the deformation and destruction of polymeric films were observed due to fibrin contraction. Further, the foreign body was covered by a connective tissue capsule. Under the action of myofibroblasts, the capsule around PHA contracted, thus further deforming and breaking the polymer. Small particles of polymer were covered by macrophages, after some time the cytoplasm of macrophages fused forming the giant cells of foreign body type. After the prolonged period, small fragments of polymeric films were almost completely degraded by macrophages. Large polymeric fragments that were not deformed or crushed, became encapsulated by fibrous tissue and remained unchanged for long time periods.

  18. Inherited infantile dilated cardiomyopathy in dogs: genetic, clinical, biochemical, and morphologic findings.

    Science.gov (United States)

    Alroy, J; Rush, J E; Freeman, L; Amarendhra Kumar, M S; Karuri, A; Chase, K; Sarkar, S

    2000-11-01

    Dilated cardiomyopathy, a lethal disease characterized by left ventricular dilation and systolic dysfunction, is relatively common in humans and other mammals. Idiopathic dilated cardiomyopathy (IDCM) is a primary myocardial disease of unknown cause and can be a familial disorder. This report describes autosomal recessive IDCM in dogs. It occurs in Portuguese Water Dog (PWD) pups and is manifested by acute, vague clinical signs and sudden death. Affected pups have progressive reduction of fractional shortening that can be demonstrated by echocardiography prior to the development of clinical signs. Furthermore, these pups have low plasma taurine levels when consuming certain diets. Affected pups had dilation of the left ventricle and alterations in the sarcomere appearance, while immunohistochemical and biochemical studies demonstrate an increase in desmin, a cytoskeleton protein. The clinical and morphologic findings of IDCM in PWDs are distinct from those reported in adult IDCM. Finally, the clinical and echocardiographic manifestations were reversible in some pups following oral taurine supplementation for 2 months. These results suggest that IDCM in PWDs is correlated with low plasma taurine levels.

  19. Pronuclear morphology evaluation in in vitro fertilization (IVF / intracytoplasmic sperm injection (ICSI cycles: a retrospective clinical review

    Directory of Open Access Journals (Sweden)

    Nicoli Alessia

    2013-01-01

    Full Text Available Abstract Background The assessment of the embryo quality is crucial to maintain an high pregnancy rate and to reduce the risk of multiple pregnancy. The evaluation of the pronuclear and nucleolar characteristics of human zygote have been proposed as an indicator of embryo development and chromosomal complement. The aim of the current study was to assess the role of pronuclear morphology evaluation in vitro fertilization (IVF / intracytoplasmic sperm injection (ICSI cycles. Methods Retrospective clinical analysis on 755 non-elective transfers of only one embryo (ET. Embryo assessment was performed in days 1 and 2. Clinical and biological data were recorded and analyzed according to embryo and/or pronuclear morphology. Results Both pronuclear and embryo morphology were significantly related to clinical pregnancy and live-birth rates. No significant difference in clinical pregnancy and live-birth rates was detected when the pronuclear and embryo morphology assessments were combined. Embryo morphology and maternal age were the only independent predictors of favorable outcome by logistic regression analysis. Conclusions Pronuclear evaluation is effective to select the best zygotes if ET is performed at day 1, whereas it did not improve the clinical outcomes when combined with embryo morphology evaluation in day 2.

  20. The effect of body position and axial load on spinal canal morphology: an MRI study of central spinal stenosis

    DEFF Research Database (Denmark)

    Madsen, Rasmus; Jensen, Tue Secher; Pope, Malcolm;

    2007-01-01

    STUDY DESIGN: A method comparison study. OBJECTIVE: To investigate the effect of body position and axial load of the lumbar spine on disc height, lumbar lordosis, and dural sac cross-sectional area (DCSA). SUMMARY OF BACKGROUND DATA.: The effects of flexion and extension on spinal canal diameters...... or not. Extensionwas the dominant cause rather than compression in reducing DCSA. Axial load was not considered to have a clinically relevant effect on spinal canal diameters....

  1. Effect of standing posture during whole body vibration training on muscle morphology and function in older adults: A randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Greene David

    2010-10-01

    Full Text Available Abstract Background Whole body vibration (WBV is a novel modality of exercise shown to improve musculoskeletal function. This study aims to examine the effects of standing posture during low magnitude WBV training on muscle function and muscle morphology in older adults. Methods Nineteen men and women (50-80 years were recruited to a three month randomised controlled trial and allocated to one of three groups: WBV with flexed knees (FK, WBV with locked knees (LK, or sham WBV with flexed knees (CON. Exposure was intermittent (1 min WBV:1 min rest for 20 min, three times per week for 13 weeks. Measurements were taken at baseline and at three months. Primary outcomes included upper and lower body muscle function (strength, power and velocity. Secondary outcomes were muscle morphology, balance, habitual and maximal gait velocity, stair climb power, and chair stand performance. Results Sixteen subjects completed the study. Relative (% upper body contraction velocity improved significantly after WBV with FK compared to LK (FK 16.0%, LK -7.6%, CON 4.7, p = 0.01. Relative upper body strength (LK 15.1%, p = 0.02; FK 12.1%, p = 0.04; CON 4.7% increased significantly following WBV compared to control. Absolute (p = 0.05 and relative (p = 0.03 lower leg strength significantly improved with both standing postures (LK 14.4%; FK 10.7%; CON 1.3%. Only the LK group differed significantly from CON in relative leg strength gains (p = 0.02. Potentially clinically meaningful but statistically non-significant improvements in lower leg muscle cross-sectional area (LK 3.7 cm2, FK 2.4 cm2, CON 2.2 cm2 p = 0.13 were observed after WBV with LK compared to the other groups. No significant effects of WBV on any functional performance tests were observed. Conclusions Our results suggest that WBV may improve muscle strength and contraction velocity in some muscle groups in older adults. However, hypothesised differential adaptation to standing posture (FK > LK was observed

  2. Relationships between internal morphology and body mass in the developing, nursling collared peccary, Tayassu tajacu (Tayassuidae).

    Science.gov (United States)

    Lochmiller, R L; Hellgren, E C; Grant, W E

    1985-01-01

    Morphological characteristics that reflect size differences due to dietary conditions are in wide use to assess nutritional status of many wild ungulates. This study was designed to provide baseline information on the development of internal visceral and endocrine structures of nursling collared peccaries (Tayassu tajacu) from birth to six weeks of age (weaning). A high energy-high protein ration was fed ad libitum to lactating females, and absolute and relative mass of selected visceral organ, endocrine, and fat depots were measured in various aged nurslings. Linear measurements were also obtained on components of the gastrointestinal tract. Allometric growth coefficients (b) varied considerably among the various organs and glands examined, ranging from below (brain, b = 0.26) to well above (thymus, b = 1.61) unity.

  3. Malignant PEComa: a case report with emphasis on clinical and morphological criteria

    Directory of Open Access Journals (Sweden)

    Legnini Margherita

    2011-01-01

    Full Text Available Abstract Background Malignant perivascular epitheliod cell tumor (PEComa is a very rare entity composed of distinctive perivascular epitheliod cells with variable immunoreactivity for melanocytic and muscle markers. At present this neoplasm does not have a known normal cellular counterpart and the natural history is often unpredictable. Up to now, few cases of PEComa have been described and treatment modalities are still controversial, particularly in advanced conditions. Case presentation We handled the case of a 42-year-old man with unresectable PEComa of the abdomen. A 7 cm hepatic hypodense lesion between segment V and VIII of the liver and diffuse intraperitoneal nodules of 0,3-3,5 cm along the right subcapsular hepatic region, were documented by a CT scan. Radiological images showed abnormal lymph nodes of the right internal mammary chain and anterior mediastinum. The patient underwent an explorative laparotomy for uncontrolled intrabdominal hemorrhage without a well-defined preoperative tumor diagnosis. At surgery, multiple lobulated nodules containing hemorrhagic fluid on the liver surface, peritoneum and omentum were confirmed. The procedure had a palliative intent and consisted of hemostasis, hematomas evacuation and omentectomy. The diagnosis of PEComa was made after surgery on the basis of morphological and immunohystochemical criteria. Radiological and intra operative findings suggest that the mass has an hepatic origin with diffuse involvement of hepatic capsule and suspensory ligaments. The patient received medical support care with blood and plasma transfusions. In our experience, PEComa was clinically malignant, leading to a fatal outcome 25 days after hospital admission of patient. Conclusions Here we report and discuss the peculiar clinical, radiological and morphological presentation of unresectable PEComa. Although in the majority of the reported series, PEComas show a more better prognosis, our case presents with a

  4. Absolute and allometric relationships between internal morphology and body mass in the adult collared peccary, Tayassu tajacu (Tayassuidae).

    Science.gov (United States)

    Lochmiller, R L; Hellgren, E C; Grant, W E

    1986-01-01

    Selected morphological features of 8 adult male and 8 adult female collared peccaries (Tayassu tajacu) shot from southern Texas during March 1983 are described. A total of 16 adult peccaries with an average body mass of 18.68 +/- 0.61 (SE) Kg was examined. Significant differences between males and females were observed for absolute and relative mass of liver and lungs, and relative heart mass. These visceral organs were heavier among females than males. Significant sex effects were also found for absolute and relative mass of the dorsal scent gland. The dorsal scent gland contributed twice as much to total body mass in males as in females. No sexual dimorphisms of the gastrointestinal tract were noted. Females had a significantly greater portion of total visceral fat deposited around the kidneys than did males. Relative mass of the mandible was significantly greater in males than in females. Adult males had extremely large accessory sex glands. The bulbourethral and seminal vesicle glands comprised 0.27 per cent of the total body mass. Allometric growth coefficients (b) varied among the various organs and glands examined, ranging from below (eyes, b = 0.34) to well above (seminal vesicles, b = 1.87) unity. Growth coefficients of lungs, kidneys, pituitary gland, and thyroid gland during adulthood greatly exceeded respective values in developing nurslings.

  5. Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis

    Institute of Scientific and Technical Information of China (English)

    Bruno Annibale; Edith Lahner; Riccardo Negrini; Flavia Baccini; Cesare Bordi; Bruno Monarca; Gianfranco Delle Fave

    2005-01-01

    AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.

  6. ANALYSIS OF FIBULARIS TERTIUS IN TERMS OF FREQUENCY, MORPHOLOGY, MORPHOMETRYAND CLINICAL SIGNIFICANCE IN NORTH INDIAN CADAVERS

    Directory of Open Access Journals (Sweden)

    Poonam Verma

    2015-12-01

    Full Text Available Introduction: The fibularis tertius muscle has always enjoyed the distinction of being an exclusively human structure and as such it has helped to separate man from the lower animals. Myocutaneous flaps have been progressively used in surgical reconstruction in the lower limb injuries requiring the use of muscles which result in less functional damage as flaps. Aim: Our study is aimed to evaluate frequency, morphology, morphometry and use of the fibularis tertius muscle as flaps in lower limb injuries. Materials and Methods: Sixty lower limbs from formalin preserved cadavers (28 male and 2 female were dissected and evaluated for the following parameters: origin of muscle, distal insertion, nerve supply, frequency, morphology, morphometry and any variation regarding this muscle. Results: The fibularis tertius muscle was detected in all the cases(60 limbs. Origin of allthe cases were found at the interosseous membrane, anterior border of the fibula, and anterior intermuscular septum. Most distal insertions were found at the medial and dorsal sides of base of the 5th metatarsal bone(98.34%. Mean value of muscle belly length was 21 cm and width was 1.9 cm. The mean length of the distal tendon with no muscle fibers up to insertion was 6 cm, and the mean width was 0.5 cm. Conclusions: The fibularis tertius muscle is frequent and has a distinct morphology, making it a feasible option for use as graft. Knowledge of these variations may have useful clinical applications in cases of leg or foot trauma requiring tendoplasty or tendon transfer operations.

  7. Morphological measurements and body indices for Cuban Creole goats and their crossbreds

    Directory of Open Access Journals (Sweden)

    Edilberto Chacón

    2011-08-01

    Full Text Available In this work, linear body measures were taken and production indices calculated for 100 Cuban Creole goats and 100 crossbred goats in order to aid in the characterization of animal genetic resources in Cuba. Low variation was found for all indices of the Creole goats, showing homogeneity between the groups of animals studied. Most of the functional indices are related to the milk biotype which is in agreement the possible origin of the breed from animals of the Iberian Peninsula and Canary Islands. The crossbreds were more varied, mostly due to undesigned disorganized crossing. These data may help in identifying a commercial niche for the breed and contribute to in situ conservation of the Cuban Creole goat.

  8. Clinical, morphological, and molecular characterization of Penicillium canis sp. nov., isolated from a dog with osteomyelitis.

    Science.gov (United States)

    Langlois, Daniel K; Sutton, Deanna A; Swenson, Cheryl L; Bailey, Chris J; Wiederhold, Nathan P; Nelson, Nathan C; Thompson, Elizabeth H; Wickes, Brian L; French, Stephanie; Fu, Jianmin; Vilar-Saavedra, Paulo; Peterson, Stephen W

    2014-07-01

    Infections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid-complexed amphotericin B initially, followed by long-term combination therapy with terbinafine and ketoconazole. A detailed morphological and molecular characterization of the mold was undertaken. Sequence analysis of the internal transcribed spacer revealed the isolate to be closely related to Penicillium menonorum and Penicillium pimiteouiense. Additional sequence analysis of β-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a novel species; the name Penicillium canis sp. nov. is proposed. Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on all media, and a failure to form ascomata distinguish this species from closely related Penicillium species.

  9. Variability of intraductal papillomas of the mammary gland: Clinical, roentgenologic and morphologic investigations

    International Nuclear Information System (INIS)

    The radiodiagnostical method of choice is the galactographic technique. However, a specific X-ray image of the papilloma does not exist. The galactographic technique has to be adapted to the surgical and histologic one. Only by combining these three techniques good results can be achieved. It is not possible to draw conclusions from the colour of the pathologic discharge about the type and character of the pathologic process. Contrary to the findings documented in the literature, we were able to diagnose with our technique not only small tumours, but also tumours situated in the periphery of the lactiferous duct. Because of our investigations it is no longer possible to maintain and keep the strict division of the proliferative changes occurring at the lactiferous duct walls. In this study, the most significant morphologic results are described in detail. In all patients with pathologic discharge of the mammary gland, the so-called papillo-carcinoma was found only in one case. As clinical consequence it has therefore to be demanded that in all women with the symptom of pathologic mamillary discharge first of all the origin of this discharge has to be localised by means of galactography. Only the individual morphologic picture of a proliferative change of the lactiferous duct provides some prognostic value. The prerequisites for such an individual assessment are differentiated roentgenologic, surgical and histological techniques. (orig./MG)

  10. Clinical and Morphological Studies on Spontaneous Cases of Pseudomonas aeruginosa Infections in Birds

    Directory of Open Access Journals (Sweden)

    I Dinev1, S Denev2* and G Beev2

    2013-07-01

    Full Text Available Clinical, pathoanatomical, histological, and bacteriological studies were performed on broiler chickens, growing broiler parents, and growing egg layers, in three different poultry farms, after an outbreak of Pseudomonas aeruginosa infections. The method of contamination of the birds was established. Several local and systemic clinico-morphological forms of spontaneous P. aeruginosa infections in various categories of stock birds were described: cases of P. aeruginosa infection resulting from injection of contaminated vaccines; case of P. aeruginosa infections through contaminated aerosol vaccine and cases of pododermatitis, periarthritis and arthritis in broiler chickens associated with P. aeruginosa infection. In different cases mortality range between 0.5 and 50%. The results showed that apart from embryonic mortality in hatcheries, and septicemic infections in newly hatched chickens, the pathogenicity of P. aeruginosa was associated with localized and systemic lesions in this category, as well as in young and growing birds. On one hand, these results have a theoretical significance, contributing for the confirmation and expansion of the wide array of clinico-morphological forms of P. aeruginosa infections in birds. On the other hand, the knowledge on these forms has a purely practical significance in the diagnostics of P. aeruginosa infections by poultry pathologists and veterinary practitioners.

  11. Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers.

    Science.gov (United States)

    Twedt, D C; Sternlieb, I; Gilbertson, S R

    1979-08-01

    In a study of 90 Bedlington Terriers, 68 had a defect that resulted in the accumulation of toxic excesses of copper in the liver. Concentrations of copper were 5 to 50 times that of clinically normal mongrel dogs. The bulk of this excess copper was sequestered in lysosomes. When copper concentrations exceeded 2,000 micrograms/g dry liver, progressive signs of functional and morphologic disturbance appeared as focal hepatitis, chronic active hepatitis, and ultimately cirrhosis. The disorder, which appears to be inherited, could only be diagnosed by liver biopsy. It was latent for many years in some dogs but led early in life to acute or chronic hepatic disease and death in others. PMID:500453

  12. Carcinoid of the ampulla of Vater: Morphologic features and clinical implications

    Institute of Scientific and Technical Information of China (English)

    George A Poultsides; Wayne AI Frederick

    2006-01-01

    Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size. Therefore,radical excision in the form of pancreaticoduodenectomy is recommended regardless of tumor size. As with other gastrointestinal carcinoid tumors, biological treatment with octreotide analogues can be applied to symptomatic patients. Tumor-targeted radioactive therapy is a newly emerging treatment option. We here report case of a carcinoid tumor of the ampulla of Vater presenting as painless jaundice in a 65-year old man and review the relevant literature, giving special attention to the morphologic features, clinical characteristics, and treatment modalities associated with this disease process.

  13. Clinical and morphological characteristics of chronic uretheroprostatitis associated with chlamydial and mycoplasmal infections

    Directory of Open Access Journals (Sweden)

    Yu. S. Kondratyeva

    2012-01-01

    Full Text Available The purpose of this study was to investigate the clinical symptoms, features of morphological structure of prostate in patients with chronic recurrent prostatitis associated with chlamydial and mycoplasmal infections. 60 male patients were examined. Anamnesis and interview data, results of laboratory and instrumental tests were analyzed. In 73.3% of cases cultural test and PCR allowed to identify M. hominis, U. urealiticum, M. genitalium, C. trachomatis in patients with chronic uretheroprostatitis. Out of 16 patients (26,6% of all examined with chronic recurrent uretheroprostatitis for whom neither chlamidial nor mycoplasmal infection was diagnosed by laboratory tests, for 14 patients (87,5% it was confirmed that patogenic urogenital infectious agents were localized intracellularly. Pathomorphological investigation of prostate bioptates allowed to estimate the type and degree of specific changes in the prostate tissue in cases of recurrent uretheroprostatitis resistant to the therapy and with frequent relapses.

  14. Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology.

    Science.gov (United States)

    Stanek, Jerzy

    2016-06-01

    To assess the usefulness and limitations of placental histology when morphological umbilical cord (UC) abnormality coexists with clinical UC compromise, 5634 consecutive placentas were divided into four groups and statistically compared: group 1-182 placentas from pregnancies with clinical features of UC compromise (variable decelerations, UC entanglement, prolapse, or true knot at delivery); group 2-1355 placentas with abnormal UC morphology or insertion; group 3-152 placentas with at least one phenotype from group 1 and one from group 2; group 4-3945 placentas with no clinical or morphological UC-related phenotypes (control group).Differences were analyzed by ANOVA or χ (2). Of 68 phenotypes studied, 13 clinical and 18 placental phenotypes were statistically significant. In group 1, 2 phenotypes were most common (oligohydramnios and abnormal fetal heart rate tracing). In group 2, 6 phenotypes were most common, including 4 clinical (abnormal umbilical artery Dopplers, nonmacerated stillbirth, multiple pregnancy, and fetal growth restriction) and 2 placental. In group 3, 23 phenotypes were most common, including 7 clinical (gestational hypertension, polyhydramnios, induction of labor, cesarean section, macerated stillbirth, congenital malformations, and abnormal 3rd stage of labor) and 16 placental. The existence of clinical signs of UC compromise alone was associated with the absence of pathomorphological placental abnormalities. However, the coexistence of clinical and abnormal morphological UC phenotypes was statistically significantly associated with placental histological signs of decreased fetal blood flow, hypoxia (acute and chronic post uterine), shallow placental implantation, and/or amnion nodosum. Thus, confirmation of clinical UC compromise should not be expected on placental examination if no morphological UC abnormality or abnormal UC insertion has been found. PMID:26983702

  15. Whole-body magnetic resonance imaging: techniques, clinical indications, and future applications.

    Science.gov (United States)

    Walker, R E; Eustace, S J

    2001-01-01

    This article reviews developments in both pulse sequence design and gradient technology that facilitate rapid imaging of the whole body. It discusses its application in patients with bone marrow neoplasms, including metastases, lymphoma, and myeloma and emphasizes the value of whole-body magnetic resonance imaging in patients with known vertebral lesions to detect other bone lesions that are easier to biopsy. It outlines possible applications in well-defined clinical situations, including pregnancy and unknown primary tumor.

  16. Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

    International Nuclear Information System (INIS)

    To determine the characteristics of femoral condyle insufficiency fracture (FCIF) lesions and their relative associations with the risk of clinical progression. This HIPAA-compliant retrospective study was approved by our Institutional Review Board. Seventy-three patients (age range, 19-95) were included after excluding patients with post-traumatic fractures, bone marrow infarct, osteochondritis dissecans, or underlying tumor. Two board-certified musculoskeletal radiologists classified morphologic findings including lesion diameter, associated bone marrow edema pattern, and associated cartilage/meniscus damage. Electronic medical charts were evaluated for symptoms, risk factors, and longitudinal outcomes, including total knee arthroplasty (TKA). Imaging characteristics were correlated with clinical findings, and comparison of outcome groups was performed using a regression model adjusted for age. The majority of patients with FCIF were women (64.4 %, 47/73), on average 10 years older than men (66.28 ± 15.86 years vs. 56.54 ± 10.39 years, p = 0.005). The most common location for FCIF was the central weight-bearing surface of the medial femoral condyle; overlying full thickness cartilage loss (75.7 %, 53/70) and ipsilateral meniscal injury (94.1 %, 64/68) were frequently associated. Clinical outcomes were variable, with 23.9 % (11/46) requiring TKA. Cartilage WORMS score, adjacent cartilage loss, and contralateral meniscal injury, in addition to decreased knee range of motion at presentation, were significantly associated with progression to TKA (p < 0.05). FCIF are frequently associated with overlying cartilage loss and ipsilateral meniscal injury. The extent of cartilage loss and meniscal damage, in addition to loss of knee range of motion at the time of presentation, are significantly associated with clinical progression. (orig.)

  17. Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome

    Energy Technology Data Exchange (ETDEWEB)

    Plett, Sara K.; Hackney, Lauren A.; Heilmeier, Ursula; Nardo, Lorenzo; Zhang, Chiyuan A.; Link, Thomas M. [Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA (United States); Yu, Aihong [Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA (United States); 4th Medical College of Peking University, Department of Radiology, Beijing Jishuitan Hospital, Beijing (China)

    2015-12-15

    To determine the characteristics of femoral condyle insufficiency fracture (FCIF) lesions and their relative associations with the risk of clinical progression. This HIPAA-compliant retrospective study was approved by our Institutional Review Board. Seventy-three patients (age range, 19-95) were included after excluding patients with post-traumatic fractures, bone marrow infarct, osteochondritis dissecans, or underlying tumor. Two board-certified musculoskeletal radiologists classified morphologic findings including lesion diameter, associated bone marrow edema pattern, and associated cartilage/meniscus damage. Electronic medical charts were evaluated for symptoms, risk factors, and longitudinal outcomes, including total knee arthroplasty (TKA). Imaging characteristics were correlated with clinical findings, and comparison of outcome groups was performed using a regression model adjusted for age. The majority of patients with FCIF were women (64.4 %, 47/73), on average 10 years older than men (66.28 ± 15.86 years vs. 56.54 ± 10.39 years, p = 0.005). The most common location for FCIF was the central weight-bearing surface of the medial femoral condyle; overlying full thickness cartilage loss (75.7 %, 53/70) and ipsilateral meniscal injury (94.1 %, 64/68) were frequently associated. Clinical outcomes were variable, with 23.9 % (11/46) requiring TKA. Cartilage WORMS score, adjacent cartilage loss, and contralateral meniscal injury, in addition to decreased knee range of motion at presentation, were significantly associated with progression to TKA (p < 0.05). FCIF are frequently associated with overlying cartilage loss and ipsilateral meniscal injury. The extent of cartilage loss and meniscal damage, in addition to loss of knee range of motion at the time of presentation, are significantly associated with clinical progression. (orig.)

  18. Body Experience and Mirror Behaviour in Female Eating Disorders Patients and non Clinical Subjects

    Directory of Open Access Journals (Sweden)

    Michel Probst

    2008-12-01

    Full Text Available Recently the attention for mirror exercises in therapies targeted specifically to body experience concerns has increased. This retrospective study will explore the mirror behaviour of anorexia nervosa (AN, bulimia nervosa (BN and non-clinical female subjects (CG and investigate whether mirror avoidance or checking are related to negative body experiences.The group of eating disorders consisted of 560 AN and 314 BN patients. The control group consisted of 1151 female subjects. The Body Attitude Test and the Eating Disorder Inventory subscales drive for thinness and body dissatisfaction were used. To explore the mirror behaviour, one item of the Body Attitude Test ‘I am observing my appearance in the mirror’ was used. Nonparametric analyses (Spearman rho correlations, Kruskal-Wallis and Mann Whitney test were used because of the categorical data.BN patients observed their body more often in the mirror than AN patients and the control subjects do. Age and BMI showed no significant main effect of mirror frequency. The relation between the frequency of mirror behaviour and body experience were significant but low (under .40. AN patients and control subjects with a mirror checking behaviour had a more negative body experience than those with mirror avoidance behaviour. In the BN group, no differences were found.There is support to integrate mirror exercises in a treatment of eating disorder patients. From a clinical point, mirror exercises are preferably combined with a body oriented therapy within a multidimensional cognitive behavioural approach. Recommendations for mirror exercises based on the clinical experience are given.

  19. Stereomicroscopic study of the human tooth caries: clinical and morphological correlations

    Science.gov (United States)

    Oancea, Roxana; Vasile, Liliana; Marchese, Cristian; Sava-Rosianu, Ruxandra

    2012-06-01

    Objectives: Stereomicroscopy allows a three-dimensional study of the images and of laterality at superior quality in comparison with other methods. Those advantages are given by the large examination fields and the wide work distances. The adding of the clinical and morphological data at the results gathered with stereomicroscopy and the stereo micrometry is useful in order to appreciate the deepness and the widening of the carious process, and the necessity to reconsider the therapeutically strategy. Materials and methods: During 2009-2011 the study material was represented by 10 surgically removed impacted third molars, and by 20 premolars extracted for orthodontic purposes, with closed and macroscopically apparently integer surfaces. 13 premolars with different degrees of carious affectation and periodontal lesions, which were surgically extracted without trauma, were also selected. The in situ measurements at the occlusal site were realized through the utilization of a fluorescent laser device - DIAGNOdent. The basic principles in stereomicroscopy stood at the base of the obliquely and circularly coaxial illumination techniques, one with optical alignment adjustment of the optical microscope and mechanical adjustment for the optimal illumination and micrometry. The Olympus Microscope SZ ×7 and an Olympus camera with 2,5 × digital zoom and a 3× optical zoom has been used to study the samples in stereomicroscopy and through polarized light it. Results: The DiagnoDent measured the following data: out of 43 apparently healthy teeth, 18 presented values between 2 and 13 (D1), 13 showed values between 14 and 24 (D2), 12 measured values over 24 (D3). After the histological examination in stereomicroscopy and in the polarized light: 25 teeth were healthy, 10 presented caries extended in dental enamel and 8 presented dentinal caries. Stereomicroscopy has allowed the morphological study, the color absorption, the appreciation of the lesions' deepness and substance

  20. Stock structure of Lake Baikal omul as determined by whole-body morphology

    Science.gov (United States)

    Bronte, Charles R.; Fleischer, G.W.; Maistrenko, S.G.; Pronin, N.M.

    1999-01-01

    In Lake Baikal, three morphotypes of omul Coregonus autumnalis migratorius are recognized; the littoral, pelagic, and deep-water forms. Morphotype assignment is difficult, and similar to that encountered in pelagic and deep-water coregonines in the Laurentian Great Lakes. Principal component analysis revealed separation of all three morphotypes based on caudal peduncle length and depth, length and depth of the body between the dorsal and anal fin, and distance between the pectoral and the pelvic fins. Strong negative loadings were associated with head measurements. Omul of the same morphotype captured at different locations were classified to location of capture using step-wise discriminant function analysis. Jackknife correct classifications ranged from 43 to 78% for littoral omul from five locations, and 45–86% for pelagic omul from four locations. Patterns of location misclassification of littoral omul suggested that the sub-population structure, hence stock affinity, may be influenced by movements and intermixing of individuals among areas that are joined bathymetrically. Pelagic omul were more distinguishable by site and may support a previous hypothesis of a spawning-based rather than a foraging-based sub-population structure. Omul morphotypes may reflect adaptations to both ecological and local environmental conditions, and may have a genetic basis.

  1. Space perception and body morphology: extent of near space scales with arm length.

    Science.gov (United States)

    Longo, Matthew R; Lourenco, Stella F

    2007-02-01

    Numerous studies have found that the near space immediately surrounding the body is represented differently than more distant space. In a previous study, we found a gradual shift in attentional bias (on a line bisection task) between near and far space (Longo and Lourenco in Neuropsychologia 44:977-981, 2006). The present study concerns the possibility that arm length relates systematically to the rate at which this gradual shift between near and far space occurs. Participants bisected lines using a laser pointer at eight distances (within and beyond arm's reach), and the rate of shift was estimated by the slope of the least-squares regression line. A negative correlation was found between the slopes and arm length; participants with longer arms showed a more gradual shift in bias with increasing distance than those with shorter arms. These results suggest that, while near space cannot be considered categorically as that within arm's reach, there is a systematic relation between the extent ("size") of near space and arm length. Arm length may constitute an intrinsic metric for the representation of near space. PMID:17256162

  2. THE CLINICAL AND MORPHOLOGICAL STUDY OF 75 CASES OF ORAL PREMALIGNANT LESIONS

    Directory of Open Access Journals (Sweden)

    Syed Salman

    2015-02-01

    Full Text Available BACKGROUND: Oral cancer is of significant public health importance to India. Oral cancer will remain a major health problem and efforts towards early detection , and prevention will reduce this burden. A premalignant lesion is a disease , syndrome , or finding that , if left untreated , may lead to cancer. OBJECTIVE: To understand the prevalence , clinical and morphological profile of oral premalignant lesions. MATERIALS AND METHODS : Clinical material for present study comp rises 75 cases with oral premalignant lesions. The parame ters studied were types of oral premalignant lesions , age distribution , sex distribution , the local habits of addiction and the sites of involvement. RESULTS : Maximum number of cases was between 21 - 3 0 years of age. The sex incidence was more in males with the ratio of 9:1. Out of total 75 cases , 64% cases were of oral submucous fibrosis , 17.3% cases were of leukoplakia , 8% cases of erythroplakia , 6.6% cases of traumatic dental ulcer and 4% cases of li chen planus. In cases of oral submucous fibrosis , betel nut chewing was the commonest habit (89.5%. In cases of Lichen planus no addictions were found. Buccal mucosa was the commonest site involved in premalignant lesions. CONCLUSION: Premalignant lesions are seen mainly in early adulthood. The number of cases is increased due to adverse oral habits. Its prevalence can be reduced if awareness is created among such patients. This study mandates close cooperation between dentist and ENT surgeons.

  3. Relationships of maternal body size and morphology with egg and clutch size in the diamondback terrapin, Malaclemys terrapin (Testudines: Emydidae)

    Science.gov (United States)

    Kern, Maximilian M.; Guzy, Jacquelyn C.; Lovich, Jeffrey E.; Gibbons, J. Whitfield; Dorcas, Michael E.

    2016-01-01

    Because resources are finite, female animals face trade-offs between the size and number of offspring they are able to produce during a single reproductive event. Optimal egg size (OES) theory predicts that any increase in resources allocated to reproduction should increase clutch size with minimal effects on egg size. Variations of OES predict that egg size should be optimized, although not necessarily constant across a population, because optimality is contingent on maternal phenotypes, such as body size and morphology, and recent environmental conditions. We examined the relationships among body size variables (pelvic aperture width, caudal gap height, and plastron length), clutch size, and egg width of diamondback terrapins from separate but proximate populations at Kiawah Island and Edisto Island, South Carolina. We found that terrapins do not meet some of the predictions of OES theory. Both populations exhibited greater variation in egg size among clutches than within, suggesting an absence of optimization except as it may relate to phenotype/habitat matching. We found that egg size appeared to be constrained by more than just pelvic aperture width in Kiawah terrapins but not in the Edisto population. Terrapins at Edisto appeared to exhibit osteokinesis in the caudal region of their shells, which may aid in the oviposition of large eggs.

  4. Anatomy and cranial functional morphology of the small-bodied dinosaur Fruitadens haagarorum from the Upper Jurassic of the USA.

    Directory of Open Access Journals (Sweden)

    Richard J Butler

    Full Text Available BACKGROUND: Heterodontosaurids are an important but enigmatic and poorly understood early radiation of ornithischian dinosaurs. The late-surviving heterodontosaurid Fruitadens haagarorum from the Late Jurassic (early Tithonian Morrison Formation of the western USA is represented by remains of several small (<1 metre total body length, <1 kg body mass individuals that include well-preserved but incomplete cranial and postcranial material. Fruitadens is hypothesized to represent one of the smallest known ornithischian dinosaurs. METHODOLOGY/PRINCIPAL FINDINGS: We describe the cranial and postcranial anatomy of Fruitadens in detail, providing comparisons to all other known heterodontosaurid taxa. High resolution micro-CT data provides new insights into tooth replacement and the internal anatomy of the tooth-bearing bones. Moreover, we provide a preliminary functional analysis of the skull of late-surviving heterodontosaurids, discuss the implications of Fruitadens for current understanding of heterodontosaurid monophyly, and briefly review the evolution and biogeography of heterodontosaurids. CONCLUSIONS/SIGNIFICANCE: The validity of Fruitadens is supported by multiple unique characters of the dentition and hindlimb as well as a distinct character combination. Fruitadens shares highly distinctive appendicular characters with other heterodontosaurids, strengthening monophyly of the clade on the basis of the postcranium. Mandibular morphology and muscle moment arms suggest that the jaws of late-surviving heterodontosaurids, including Fruitadens, were adapted for rapid biting at large gape angles, contrasting with the jaws of the stratigraphically older Heterodontosaurus, which were better suited for strong jaw adduction at small gapes. The lack of wear facets and plesiomorphic dentition suggest that Fruitadens used orthal jaw movements and employed simple puncture-crushing to process food. In combination with its small body size, these results

  5. Effect of paracetamol (acetaminophen) on body temperature in acute ischemic stroke: a double-blind, randomized phase II clinical trial

    NARCIS (Netherlands)

    D.W.J. Dippel (Diederik); E.J. van Breda (Eric); H.M.A. van Gemert (Maarten); H.B. van der Worp (Bart); R.J. Meijer (Ron); L.J. Kappelle (Jaap); P.J. Koudstaal (Peter Jan)

    2001-01-01

    textabstractBACKGROUND AND PURPOSE: Body temperature is a strong predictor of outcome in acute stroke. However, it is unknown whether antipyretic treatment leads to early and clinically worthwhile reduction of body temperature in patients with acute stroke, especially w

  6. Comparative Analysis of Clinical, Hormonal and Morphological Studies in Patients with Neuroendocrine ACTH-Producing Tumours

    Directory of Open Access Journals (Sweden)

    G. S. Kolesnikova

    2013-01-01

    Full Text Available This paper highlights the problem of neuroendocrine tumours (NETs with clinical symptoms of hypercorticism caused by hypersecretion of adrenocorticotropic hormone (ACTH by tumour cells. In most cases (85%, the tumours were localized in the pituitary gland (Cushing's disease; 15% of the patients had an extrapituitary tumour that manifest as an ectopic ACTH secretion (EAS. Comparative analysis of clinical, hormonal, histological, and immunohistochemical characteristics of pituitary and extrapituitary ACTH-secreting NET was performed. It included 46 patients with CD and 38 ones exhibiting ectopic ACTH secretion (EAS. Results of the study suggest differences between CD and EAS in terms of the severity of clinical manifestations and duration of the disease. Hormonal studies showed that EAS unlike CD was associated with high plasma ACTH and cortisol levels, late-evening salivary cortisol and daily urinary free cortisol, the absence of a 60% or greater reduction of cortisol in the HDDST test, and the presence of a low (less than 2 ACTH gradient in response to desmopressin administration with catheterization of cavernous sinuses. The study of morphofunctional characteristics of the removed NET demonstrated the ability of both pituitary and extrapituitary NETs to express ACTH as well as GH, PRL, LH, and FSH. The angiogenic markers (CD31 and VEGF were detected with equal frequency regardless of the NET localization. The histological structure of all corticotropinomas suggested their benign origin, but extrapituitary NETs were represented by different morphological types with varying malignancy, invasiveness, and metastatic properties. A higher cell proliferation potential (Ki-67 was documented for NET in patients presenting with an ectopic ACTH secretion compared to those having corticotropinomas.

  7. Clinical characteristics of airway foreign bodies in which bronchoscopic removal was difficult

    International Nuclear Information System (INIS)

    Airway foreign bodies may cause suffocation and pneumonia. Therefore, accurate diagnosis and expeditious removal are needed. However, we sometimes experience difficulty in removing foreign bodies from the airway by bronchoscopy. We examined the clinical characteristics of 15 cases of foreign body managed in our institute over the past 19 years, and evaluated characteristic difficulties during bronchoscopic removal. The mean age of cases was 58 years. Four patients had dementia as their underlying disease. Episodes of aspiration occurred in 10 patients. Dental foreign bodies were seen in 9 patients (60%). Chest X-ray films detected foreign bodies in 11 patients (73%), and chest computed tomography identified them in all patients. Alligator forceps and basket forceps were mainly used for removal. Fogarty forceps were also used in combination with the above in 2 patients. The foreign body was removed during the first procedure in 12 patients; however, further procedures were needed (20%) in the remaining 3 patients: using different bronchoscopic techniques, tracheotomy and surgical resection, respectively. The characteristics of these 3 cases were as follows; granulation forming around a sharp foreign body obstructing the bronchus for a prolonged period, inability of the patient to lie still due to dementia, and tracheal stenosis after tracheotomy. Characteristic difficulties during bronchoscopic removal were granulation around the foreign body, inability of the patient to lie still, and tracheal stenosis. When difficulties in bronchoscopic removal are expected, it is necessary to prepare a variety of devices in advance. (author)

  8. Image artifacts from MR-based attenuation correction in clinical, whole-body PET/MRI

    DEFF Research Database (Denmark)

    Keller, Sune H; Holm, Søren; Hansen, Adam E;

    2013-01-01

    Integrated whole-body PET/MRI tomographs have become available. PET/MR imaging has the potential to supplement, or even replace combined PET/CT imaging in selected clinical indications. However, this is true only if methodological pitfalls and image artifacts arising from novel MR-based attenuation...

  9. Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

    NARCIS (Netherlands)

    Karakatsanis, Nicolas A.; Zhou, Yun; Lodge, Martin A.; Casey, Michael E.; Wahl, Richard L.; Zaidi, Habib; Rahmim, Arman

    2015-01-01

    We recently developed a dynamic multi-bed PET data acquisition framework to translate the quantitative benefits of Patlak voxel-wise analysis to the domain of routine clinical whole-body (WB) imaging. The standard Patlak (sPatlak) linear graphical analysis assumes irreversible PET tracer uptake, ign

  10. [Human body meridian spatial decision support system for clinical treatment and teaching of acupuncture and moxibustion].

    Science.gov (United States)

    Wu, Dehua

    2016-01-01

    The spatial position and distribution of human body meridian are expressed limitedly in the decision support system (DSS) of acupuncture and moxibustion at present, which leads to the failure to give the effective quantitative analysis on the spatial range and the difficulty for the decision-maker to provide a realistic spatial decision environment. Focusing on the limit spatial expression in DSS of acupuncture and moxibustion, it was proposed that on the basis of the geographic information system, in association of DSS technology, the design idea was developed on the human body meridian spatial DSS. With the 4-layer service-oriented architecture adopted, the data center integrated development platform was taken as the system development environment. The hierarchical organization was done for the spatial data of human body meridian via the directory tree. The structured query language (SQL) server was used to achieve the unified management of spatial data and attribute data. The technologies of architecture, configuration and plug-in development model were integrated to achieve the data inquiry, buffer analysis and program evaluation of the human body meridian spatial DSS. The research results show that the human body meridian spatial DSS could reflect realistically the spatial characteristics of the spatial position and distribution of human body meridian and met the constantly changeable demand of users. It has the powerful spatial analysis function and assists with the scientific decision in clinical treatment and teaching of acupuncture and moxibustion. It is the new attempt to the informatization research of human body meridian. PMID:26946752

  11. [Human body meridian spatial decision support system for clinical treatment and teaching of acupuncture and moxibustion].

    Science.gov (United States)

    Wu, Dehua

    2016-01-01

    The spatial position and distribution of human body meridian are expressed limitedly in the decision support system (DSS) of acupuncture and moxibustion at present, which leads to the failure to give the effective quantitative analysis on the spatial range and the difficulty for the decision-maker to provide a realistic spatial decision environment. Focusing on the limit spatial expression in DSS of acupuncture and moxibustion, it was proposed that on the basis of the geographic information system, in association of DSS technology, the design idea was developed on the human body meridian spatial DSS. With the 4-layer service-oriented architecture adopted, the data center integrated development platform was taken as the system development environment. The hierarchical organization was done for the spatial data of human body meridian via the directory tree. The structured query language (SQL) server was used to achieve the unified management of spatial data and attribute data. The technologies of architecture, configuration and plug-in development model were integrated to achieve the data inquiry, buffer analysis and program evaluation of the human body meridian spatial DSS. The research results show that the human body meridian spatial DSS could reflect realistically the spatial characteristics of the spatial position and distribution of human body meridian and met the constantly changeable demand of users. It has the powerful spatial analysis function and assists with the scientific decision in clinical treatment and teaching of acupuncture and moxibustion. It is the new attempt to the informatization research of human body meridian.

  12. Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case

    Directory of Open Access Journals (Sweden)

    Arturo González-Robles

    2014-01-01

    Full Text Available Light and transmission electron microscopy observations are reported on the structure and in vitro cytopathic effect of Acanthamoeba griffini trophozoites isolated from a clinical case. Live trophozoites were moderately active with a remarkable pleomorphism which changed from ovoid to quite elongated shapes. When moving, amoebae formed cytoplasmic projections such as wide lamellae and acanthopodia of diverse size and thickness which contain a significant amount of actin. Ultrastructurally, the cytoplasm showed the main organelles found in other free-living amoebae. Coincubation of trophozoites with MDCK cell monolayers resulted in a local damage to target cells after 24 h of interaction, suggesting that the cytopathic effect is contact-dependent. By transmission electron microscopy, amoebae appeared to engulf small portions of the MDCK cells; however, the cells that were not in contact with trophozoites had an unaltered morphology. When epithelial monolayers were incubated with conditioned medium for 24 h, small areas of cell injury were also observed. The phylogenetical analysis as well as the sequencing of the acquired amplified product for the DF3 region of the amoebae isolate confirmed that it belongs to genotype T3, which includes other pathogenic amoebae; besides the activity of two drugs currently used against Acanthamoeba was tested on A. griffini.

  13. Clinical, morphological, and biochemical phenotype of a new case of Ehlers-Danlos syndrome type VIIC.

    Science.gov (United States)

    Fujimoto, A; Wilcox, W R; Cohn, D H

    1997-01-10

    Ehlers-Danlos syndrome (EDS) type VIIC is a newly recognized human disorder which results from failure to remove the amino-terminal propeptide of type I procollagen. Four cases of EDS type VIIC have been reported, and here we describe a fifth case. The propositus was a 1,445 g male infant born at 30 weeks of gestation following premature rupture of membranes. He had wide fontanelles, prominent eyes with swollen eyelids and blue sclerae, anteverted nostrils, micrognathia, umbilical hernia, short stubby fingers, and cutis laxa with hirsutism. At age 3 months, during the repair of the umbilical hernia, he was noted to have unusual skin fragility. Examination of skin by scanning electron microscopy showed frayed collagen fibrils, and transmission electron microscopy showed the hieroglyphic collagen fibril morphology characteristic of the disorder. As reported in other cases, cultured fibroblasts synthesized type I procollagen that was very poorly processed at the amino-terminal propeptide cleavage site. the 5 known cases of human EDS type VIIC characterize a distinct clinical phenotype, making this condition recognizable at birth before manifestation of severe skin fragility. The diagnosis can be confirmed by biochemical studies of type I procollagen synthesis and by electron microscopic examination of skin. PMID:8986271

  14. Morphological, immunophenotypic and clinical characteristics of dogs with lymphocytic - plasmacytic duodenitis

    Directory of Open Access Journals (Sweden)

    Đorđević Milena

    2012-01-01

    Full Text Available The most important morphological feature of the immune response in lymphocytic-plasmacytic duodenitis (LPD in dogs is the presence of a mononuclear infiltrate in the duodenal mucosa. The ethiopatogenesis of this disease is still unknown, nor are known all the immunophenotypic characteristics of the infiltrate cells, which would be of help in the elucidation of the pathogenesis of LPD. The study involved 60 adult dogs of different breeds and both sexes: 54 dogs with symptoms of diarrhea and vomiting that lasted longer than three weeks and six clinically healthy dogs that served as controls. Hematological and biochemical analysis of blood, radiology, ultrasound and endoscopic diagnosis were carried out. Samples of duodenal mucosal biopta were examined by histopathological and immunohistochemical methods. During endoscopic examination, duodenal wall thickening, mucosal edema and hyperemia were observed in 46 dogs. Microscopic studies showed on the epithelial cells of the duodenum degenerative changes, and sometimes desquamation. Most of the intestinal crypts were dilated, irregularly shaped and filled with detritus. On immunohistochemical examination of samples of the duodenum in a number of dogs with LPD a predominant expression of CD3 + T lymphocytes was observed. [Projekat Ministarstva nauke Republike Srbije, br. III 46002

  15. Effect of directional selection for body size on fluctuating asymmetry in certain morphological traits in Drosophila ananassae

    Indian Academy of Sciences (India)

    C Vishalakshi; B N Singh

    2009-06-01

    Variation in the subtle differences between the right and left sides of bilateral characters or fluctuating asymmetry (FA) has been considered as an indicator of an organism’s ability to cope with genetic and environmental stresses during development. However, due to inconsistency in the results of empirical studies, the relationship between FA and stress has been the subject of intense debate. In this study, we investigated whether stress caused by artificial bidirectional selection for body size has any effect on the levels of FA of different morphological traits in Drosophila ananassae. The realised heritability (h2) was higher in low-line females and high-line males, which suggests an asymmetrical response to selection for body size. Further, the levels of FA were compared across 10 generations of selection in different selection lines in both sexes for sternopleural bristle number, wing length, wing-to-thorax ratio, sex combtooth number and ovariole number. The levels of FA differed significantly among generations and selection lines but did not change markedly with directional selection. However, the levels of FA were higher in the G10 generation (at the end of selection) than G0 (at the start of selection) but lower than the G5 generation in different selection lines, suggesting that the levels of FA are not affected by the inbreeding generated during the course of selection. Also, the levels of FA in the hybrids of high and low lines were significantly lower than the parental selection lines, suggesting that FA is influenced by hybridisation. These results are discussed in the framework of the literature available on FA and its relationship with stress.

  16. Foreign body granuloma mimicking recurrent intracranial tumor: a very rare clinical entity.

    Directory of Open Access Journals (Sweden)

    Askin Esen Hasturk

    2013-11-01

    Full Text Available Gelatin sponge, oxidized cellulose and microfibrillar collagen are used to achieve hemostasis during neurosurgical procedures. Hemostatic agents may produce clinically symptomatic, radiologically apparent mass lesions. The differential diagnosis should include the foreign body along with recurrent tumor. We present a case of intracranial hemostatic agents found in a 56-year-old male patient seven years after undergoing a craniotomy for a left posterior parietal convexity meningioma. Preoperative magnetic resonance imaging (MRI suggested the presence of a recurrent tumor. We emphasize that although it is rare, a granuloma due to a foreign body reaction can result in a false image of tumor recurrence.

  17. Soft-Body Muscles for Evolved Virtual Creatures: The Next Step on a Bio-Mimetic Path to Meaningful Morphological Complexity

    DEFF Research Database (Denmark)

    Lessin, Dan; Risi, Sebastian

    2015-01-01

    In the past, evolved virtual creatures (EVCs) have been developed with rigid, segmented bodies, and with soft bodies, but never before with a combination of the two. In nature, however, creatures combining a rigid skeleton and non-rigid muscles are some of the most complex and successful examples......, able to drive a rigid-body skeleton. In this way, we can begin to bridge the gap between articulated and softbodied EVCs, and take the next step on a nature-inspired path to meaningful morphological complexity for evolved virtual creatures....

  18. Effects of intermittent fasting on body composition and clinical health markers in humans.

    Science.gov (United States)

    Tinsley, Grant M; La Bounty, Paul M

    2015-10-01

    Intermittent fasting is a broad term that encompasses a variety of programs that manipulate the timing of eating occasions by utilizing short-term fasts in order to improve body composition and overall health. This review examines studies conducted on intermittent fasting programs to determine if they are effective at improving body composition and clinical health markers associated with disease. Intermittent fasting protocols can be grouped into alternate-day fasting, whole-day fasting, and time-restricted feeding. Alternate-day fasting trials of 3 to 12 weeks in duration appear to be effective at reducing body weight (≈3%-7%), body fat (≈3-5.5 kg), total cholesterol (≈10%-21%), and triglycerides (≈14%-42%) in normal-weight, overweight, and obese humans. Whole-day fasting trials lasting 12 to 24 weeks also reduce body weight (≈3%-9%) and body fat, and favorably improve blood lipids (≈5%-20% reduction in total cholesterol and ≈17%-50% reduction in triglycerides). Research on time-restricted feeding is limited, and clear conclusions cannot be made at present. Future studies should examine long-term effects of intermittent fasting and the potential synergistic effects of combining intermittent fasting with exercise. PMID:26374764

  19. The prevalence of body dysmorphic disorder and its clinical correlates in a VA primary care behavioral health clinic.

    Science.gov (United States)

    Kelly, Megan M; Zhang, Jinxin; Phillips, Katharine A

    2015-07-30

    We examined the prevalence of body dysmorphic disorder (BDD) in a Veterans Affairs (VA) primary care behavioral health clinic. Of 100 Veterans, 11% (95% CI = 6.3-18.6%) had current BDD and 12% (95% CI = 7.0-19.8%) had lifetime BDD. However, only 8.3% of these Veterans had been diagnosed with BDD. BDD was significantly associated with a substantially elevated rate of suicide attempts, major depression, and obsessive-compulsive disorder. This severe disorder appears to be underdiagnosed in VA settings. PMID:25935375

  20. Foreign body aspiration in children: clinical aspects, radiological aspects and bronchoscopic treatment

    International Nuclear Information System (INIS)

    Objective: To describe the clinical manifestations and bronchoscopic treatment of foreign body aspiration in children under 14 years of age, correlating the clinical aspects with the bronchoscopic findings. Methods: A retrospective, descriptive study analyzing data related to children under 14 years of age undergoing bronchoscopy due to clinical suspicion of foreign body aspiration at the State University at Campinas Hospital das Clinicas from January of 2000 to December of 2005. Results: The sample consisted of 69 patients, ranging in age from 8 months to 12 years/7 months (75.4% under 3 years of age), 62.3% of whom were male. The principal complaint was sudden-onset cough (75.4%), auscultation was abnormal in 74%, and dyspnea was observed in 29%. Radiological abnormalities were seen in 88% of the cases. Aspirations were primarily into the right lung (54.8%), and 30.7% of the foreign bodies were of vegetal origin (principally beans and peanuts). In the follow-up period, 29% presented complications (most commonly pneumonia), which were found to be associated with longer aspiration time (p = 0.03). Mechanical ventilation was required in 7 children (10.1%), and multiple bronchoscopies were performed in 5 (7.2%). Conclusions: A history of sudden-onset choking and cough, plus abnormal auscultation and radiological findings, characterizes the profile of foreign body aspiration. In such cases, bronchoscopy is indicated. Longer aspiration time translates to a higher risk of complications. The high prevalence of foreign bodies of vegetal origin underscores the relevance of prevention at children younger than three years of age. (author)

  1. Prevalence of body mass index and body weight cut-off points for in vitro fertilization treatment at U.S. clinics and current clinic weight loss strategy recommendations.

    Science.gov (United States)

    Turner-McGrievy, Gabrielle M; Grant, Breănna L

    2015-09-01

    The goal of this study was to determine how many clinics providing in vitro fertilization (IVF) in the United States require a body mass index (BMI) or body weight cut-off point to determine treatment eligibility. US clinics listed as members on the Society of Assisted Reproduction website in late 2013 were contacted by phone between January and March 2014. Clinic personnel were asked if a BMI or body weight cut-off points was used to determine IVF treatment eligibility and what strategies they recommended for their patients to achieve a healthy body weight. Of the 379 clinics contacted, 347 responded (92% response rate) and 35% (n = 120) reported using a BMI or body weight cut-off points to determine eligibility for IVF treatment. Mean BMI (± SD) cut-off points was 38.4 ± 5.2 kg/m(2) and mean body weight (± SD) cut-off points was 130.2 ± 14.8 kg. Of the clinics using a set cut-off points, half (46%) provided no weight loss recommendations for patients. A sizable portion of US IVF clinics report a required or preferred BMI or body weight cut-off points for treatment. Despite this, most clinics did not provide a recommended program or approach for weight loss with very few clinics reporting an in-house program.

  2. The clinical features of foreign body aspiration into the lower airway in geriatric patients

    Directory of Open Access Journals (Sweden)

    Lin LJ

    2014-09-01

    Full Text Available Lianjun Lin,1 Liping Lv,2,* Yuchuan Wang,1 Xiankui Zha,2 Fei Tang,2 Xinmin Liu1,* 1Geriatric Department, Peking University First Hospital, Beijing, People’s Republic of China; 2Pulmonary Intervention Department, Anhui Chest Hospital, Hefei, People’s Republic of China *These authors contributed equally to this work Purpose: To analyze the clinical features of foreign-body aspiration into the lower airway in geriatric patients. Patients and methods: The clinical data of 17 geriatric patients with foreign-body aspiration were retrospectively analyzed and compared with 26 nongeriatric adult patients. The data were collected from Peking University First Hospital and Anhui Chest Hospital between January 2000 and June 2014.Results: (1 In the geriatric group, the most common symptoms were cough and sputum (15 cases, 88%, dyspnea (six cases, 35%, and hemoptysis (four cases, 24%. Five patients (29% in the geriatric group could supply the history of aspiration on their first visit to doctor, a smaller percentage than in the nongeriatric group (13 cases, 50%. Only three cases in the geriatric group were diagnosed definitely without delay. Another 14 cases were misdiagnosed as pneumonia or lung cancer, and the time of delayed diagnosis ranged from 1 month to 3 years. Complications due to delay in diagnosis included obstructive pneumonitis, atelectasis, lung abscess, and pleural effusion. (2 Chest computed tomography demonstrated the foreign body in three cases (21% in the geriatric group, which was lower than the positive proportion of detection in the nongeriatric group (nine cases, 35%. The most common type of foreign body in the geriatric group was food, such as bone fragments (seven cases, 41% and plants (seven cases, 41%, and the foreign body was most often lodged in the right bronchus tree (eleven cases, 65%, especially the right lower bronchus (seven cases, 41%. Flexible bronchoscopy removed the foreign body successfully in all patients

  3. Clinical and radiographic evaluation of biodegradable bone plates in the treatment of mandibular body fractures

    Directory of Open Access Journals (Sweden)

    Sherin Kamal Elhalawany

    2015-01-01

    Full Text Available Background: Many different systems are available for the treatment of fractures ranging from the heavy compression plates for mandibular reconstruction to low profile plates for mid-facial fixation, and are made either from stainless steel, titanium or vitallium. Recently, biodegradable, self-reinforced polylactide plates and screws have been used for the internal fixation of fractures of the mandible with good results. Aim of this study: This study evaluated clinically the biodegradable bone plates for treatment of mandibular body fracture and to evaluate bone healing during the follow-up period using digital radiography. Materials and Methods : Eight patients had been suffered from mandibular body fractures were treated using Inion CPS TM bioresorbable fixation system and the healing process were followed up using digitised panoramic radiography at first week and after 1, 3 and 6 months. Results: Clinical examination of fractured segments revealed stable fixation across the fracture sites while visual and quantitative assessment of radiograph showed healing process was comparable with results previously reported by titanium bone plates. Conclusion: Open reduction and internal fixation of mandibular fractures using bioresorbable fixation system with a brief period of inter-maxillary fixation have evolved to the point where the physical properties are sufficient to withstand the post-operative loads required for fracture repair of mandibular body fractures. The foreign body reaction is a major material-related problem which requires further studies.

  4. Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.

    Directory of Open Access Journals (Sweden)

    Pika Miklavc

    Full Text Available Leucine-rich repeat kinase 2 (LRRK2 is known to play a role in the pathogenesis of various diseases including Parkinson disease, morbus Crohn, leprosy and cancer. LRRK2 is suggested to be involved in a number of cell biological processes such as vesicular trafficking, transcription, autophagy and lysosomal pathways. Recent histological studies of lungs of LRRK2 knock-out (LRRK2 -/- mice revealed significantly enlarged lamellar bodies (LBs in alveolar type II (ATII epithelial cells. LBs are large, lysosome-related storage organelles for pulmonary surfactant, which is released into the alveolar lumen upon LB exocytosis. In this study we used high-resolution, subcellular live-cell imaging assays to investigate whether similar morphological changes can be observed in primary ATII cells from LRRK2 -/- rats and whether such changes result in altered LB exocytosis. Similarly to the report in mice, ATII cells from LRRK2 -/- rats contained significantly enlarged LBs resulting in a >50% increase in LB volume. Stimulation of ATII cells with ATP elicited LB exocytosis in a significantly increased proportion of cells from LRRK2 -/- animals. LRRK2 -/- cells also displayed increased intracellular Ca(2+ release upon ATP treatment and significant triggering of LB exocytosis. These findings are in line with the strong Ca(2+-dependence of LB fusion activity and suggest that LRRK2 -/- affects exocytic response in ATII cells via modulating intracellular Ca(2+ signaling. Post-fusion regulation of surfactant secretion was unaltered. Actin coating of fused vesicles and subsequent vesicle compression to promote surfactant expulsion were comparable in cells from LRRK2 -/- and wt animals. Surprisingly, surfactant (phospholipid release from LRRK2 -/- cells was reduced following stimulation of LB exocytosis possibly due to impaired LB maturation and surfactant loading of LBs. In summary our results suggest that LRRK2 -/- affects LB size, modulates intracellular Ca(2

  5. [Body dysmorphic disorder: clinical aspects, nosological dimensions and controversies with anorexia nervosa].

    Science.gov (United States)

    Behar, Rosa; Arancibia, Marcelo; Heitzer, Cristóbal; Meza, Nicolás

    2016-05-01

    There is strong evidence about the co-existence of body dysmorphic disorder (BDD) and eating disorders (ED), particularly with anorexia nervosa (AN). An exhaustive review of the specialised literature regarding these disorders was carried out. The results show that their co-occurrence implies a more complex diagnosis and treatment, a more severe clinical symptomatology and a worse prognosis and outcome. Both disorders display common similarities, differences and comorbidities, which allow authors to classify them in different nosological spectra (somatomorphic, anxious, obsessive-compulsive, affective and psychotic). Their crossover involves higher levels of body dissatisfaction and body image distortion, depression, suicidal tendency, personality disorders, substance use/abuse, obsessive-compulsive disorder, social phobia, alexithymia and childhood abuse or neglect background. Treatment including cognitive-behavioral psychotherapy and selective reuptake serotonin inhibitors are effective for both, BDD and ED; nevertheless, plastic surgery could exacerbate BDD. Clinical traits of BDD must be systematically detected in patients suffering from ED and vice versa. PMID:27552014

  6. 3D morphology of the rear foot from MRI data: technical validation and clinical description

    Science.gov (United States)

    Stindel, Eric; Udupa, Jayaram K.; Hirsch, Bruce E.; Odhner, Dewey; Couture, Christine

    1998-06-01

    The purpose of this work is to characterize the 3D morphology of the bones of the rear foot using MR data. This work has two subaims: (1) to study the variability of the various computed architectural measures as a result of the subjectivity and variations in the various processing operations; (2) to study the morphology of the bones included in the peritalar complex. Each image data set utilized in this study consists of 60 longitudinal slices of the foot acquired on a 1.5 T commercial GE MR system. Our description of the rear foot morphology is based mainly on the principal axes, which represent the inertia axes of the bones, as well as on the bone surfaces. We use the live-wire method for segmenting and forming the surfaces of the bones. In the first part of this work, we focus on the dependence of the principal axes system on segmentation and on scan orientation. In the second part, we describe the normal morphology of the rear foot considering the four bones (calcaneus, cuboid, navicular, talus) and compare them to a population from the Upper Pleistocene. We conclude that this non-invasive method can be used in live patients to characterize the bone morphology or as a comparative method to classify population of bones. in spite of the variations involved in the various processing operations.

  7. Whole body vibration for older persons: an open randomized, multicentre, parallel, clinical trial

    Directory of Open Access Journals (Sweden)

    Sitjà-Rabert Mercè

    2011-12-01

    Full Text Available Abstract Background Institutionalized older persons have a poor functional capacity. Including physical exercise in their routine activities decreases their frailty and improves their quality of life. Whole-body vibration (WBV training is a type of exercise that seems beneficial in frail older persons to improve their functional mobility, but the evidence is inconclusive. This trial will compare the results of exercise with WBV and exercise without WBV in improving body balance, muscle performance and fall prevention in institutionalized older persons. Methods/Design An open, multicentre and parallel randomized clinical trial with blinded assessment. 160 nursing home residents aged over 65 years and of both sexes will be identified to participate in the study. Participants will be centrally randomised and allocated to interventions (vibration or exercise group by telephone. The vibration group will perform static/dynamic exercises (balance and resistance training on a vibratory platform (Frequency: 30-35 Hz; Amplitude: 2-4 mm over a six-week training period (3 sessions/week. The exercise group will perform the same exercise protocol but without a vibration stimuli platform. The primary outcome measure is the static/dynamic body balance. Secondary outcomes are muscle strength and, number of new falls. Follow-up measurements will be collected at 6 weeks and at 6 months after randomization. Efficacy will be analysed on an intention-to-treat (ITT basis and 'per protocol'. The effects of the intervention will be evaluated using the "t" test, Mann-Witney test, or Chi-square test, depending on the type of outcome. The final analysis will be performed 6 weeks and 6 months after randomization. Discussion This study will help to clarify whether WBV training improves body balance, gait mobility and muscle strength in frail older persons living in nursing homes. As far as we know, this will be the first study to evaluate the efficacy of WBV for the

  8. Morphology as a key to behavioural flexibility: body shape and swimming variability in the dimorphic crucian carp

    Directory of Open Access Journals (Sweden)

    L. B. Pettersson

    2007-12-01

    Full Text Available Swimming trajectories of length-matched deep-bodied and shallow-bodied crucian carp were quantified in the laboratory using motion analysis software and compared in terms of swimming velocity, turning behaviour and associated coefficients of variation. The mean velocities of the two morphs were similar, but slower than predicted, and there was no difference in turning behaviour. In line with predictions from analysis of power curve steepness, swimming velocities of deep-bodied, high-drag individuals were significantly less variable than shallow-bodied conspecifics, thus indicating an association between body shape behavioural flexibility in terms of swimming variability.

  9. Striatal Dopamine Transporter Binding Does Not Correlate with Clinical Severity in Dementia with Lewy Bodies

    DEFF Research Database (Denmark)

    Ziebell, Morten; Andersen, Birgitte B; Pinborg, Lars H;

    2013-01-01

    Patients who have dementia with Lewy bodies (DLB) show both clinical and histopathologic overlap with Alzheimer disease patients and Parkinson disease patients. In this study, we correlated the core features of DLB (dementia, parkinsonism, hallucinations, and fluctuations) with striatal dopamine...... transporter (DAT) availability as assessed with SPECT and (123)I-N-(3-iodoprop-2E-enyl)-2-β-carbomethoxy-3β-(4-methylphenyl) nortropane ((123)I-PE2I) in patients with newly diagnosed DLB. METHODS: Two hundred eighty-eight patients were consecutively included in the study as they were referred for diagnostic...

  10. The Mallory body

    DEFF Research Database (Denmark)

    Jensen, K; Gluud, C

    1994-01-01

    To aid understanding of markers of disease and predictors of outcome in alcohol-exposed systems, we undertook a literature survey of more than 700 articles to view the morphological characteristics and the clinical and experimental epidemiology of the Mallory body. Mallory bodies are filaments...... suggest a hit-and-run effect of alcohol, whereas other chronic liver diseases show evidence of gradual increase in prevalence of Mallory bodies with severity of hepatic pathology. Mallory bodies in cirrhosis do not imply alcoholic pathogenesis. Obesity, however, is associated with alcoholism and diabetes...

  11. Clinical and diagnostic methods for evaluation of sharp foreign body syndrome in buffaloes

    Directory of Open Access Journals (Sweden)

    Nasr-Eldin M. Aref

    2013-06-01

    Full Text Available Aim: The present study was designed to evaluate clinically and under laboratory condition the sharp foreign body syndrome (SFBS in buffaloes with special emphasis on the diagnostic value of radiography, ultrasonography and blood gases and acidbase balance. Materials and Methods: 196 buffaloes with a history of anorexia, reduction of milk production and no response to previous medical treatment were included in the present study. These animals were subjected to clinical and radiographical examinations. Positive cases for SFBS were further evaluated by sonography, hemato-biochemical and blood gas and acid base balance analysis.Results: Out of 196 admitted cases, 49 (25% cases were confirmed as SFBS by clinical and radiographical examination. Positive cases were subsequently divided into two main categories (complicated and non complicated according to radiographical and sonographical findings. SFBS with no complication was diagnosed in 16 cases while 33 cases showed various degrees of complication including reticular adhesion (abdominal and diaphragmatic, n= 23, diaphragmatic hernia (n = 6 and traumatic pericarditis (n = 4. Leukocytosis, hyperprotenemia and increased activity of AST and ALT were of additional values in the diagnosis of SFBS. A consistent finding of primary metabolic alkalosis was recorded in all cases except one with advanced traumatic pericarditis that showed metabolic acidosis. Conclusion: While there is no substitution for clinical examination, using of ultrasonography and radiography simultaneously are essential for proper evaluation and differentiation between various sequelae of SFBS in buffaloes. Radiography is an efficient tool for visualization of metallic foreign body while ultrasonography is an excellent device in assessing fibrinous deposits. Hemato-biochemical and blood gases and acid base balance are of additional values in discriminating between various outcomes of SFBS.

  12. Dynamic whole-body PET parametric imaging: I. Concept, acquisition protocol optimization and clinical application

    Science.gov (United States)

    Karakatsanis, Nicolas A.; Lodge, Martin A.; Tahari, Abdel K.; Zhou, Y.; Wahl, Richard L.; Rahmim, Arman

    2013-10-01

    Static whole-body PET/CT, employing the standardized uptake value (SUV), is considered the standard clinical approach to diagnosis and treatment response monitoring for a wide range of oncologic malignancies. Alternative PET protocols involving dynamic acquisition of temporal images have been implemented in the research setting, allowing quantification of tracer dynamics, an important capability for tumor characterization and treatment response monitoring. Nonetheless, dynamic protocols have been confined to single-bed-coverage limiting the axial field-of-view to ˜15-20 cm, and have not been translated to the routine clinical context of whole-body PET imaging for the inspection of disseminated disease. Here, we pursue a transition to dynamic whole-body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging methods. We investigate solutions to address the challenges of: (i) long acquisitions, (ii) small number of dynamic frames per bed, and (iii) non-invasive quantification of kinetics in the plasma. In the present study, a novel dynamic (4D) whole-body PET acquisition protocol of ˜45 min total length is presented, composed of (i) an initial 6 min dynamic PET scan (24 frames) over the heart, followed by (ii) a sequence of multi-pass multi-bed PET scans (six passes × seven bed positions, each scanned for 45 s). Standard Patlak linear graphical analysis modeling was employed, coupled with image-derived plasma input function measurements. Ordinary least squares Patlak estimation was used as the baseline regression method to quantify the physiological parameters of tracer uptake rate Ki and total blood distribution volume V on an individual voxel basis. Extensive Monte Carlo simulation studies, using a wide set of published kinetic FDG parameters and GATE and XCAT platforms, were conducted to optimize the acquisition protocol from a range of ten different clinically

  13. Morphologic Study of Superior Temporal Sulcus-Amygdaloid Body and Lateral Fissure-Amygdaloid Body Surgical Approach by Using Magnetic Resonance Imaging Volume Rendering.

    Science.gov (United States)

    Qu, Yuan; Ren, Bichen; Chang, Xiaoyu; Zhang, Jinnan; Li, Youqiong; Duan, Haobo; Cheng, Kailiang; Wang, Jincheng

    2016-01-01

    In this research, 83 patients were measured by magnetic resonance imaging volume rendering technique. The authors acquired the curve length of the superior temporal sulcus and the lateral fissure on the cerebral hemisphere, the shortest distance from the superior temporal sulcus and the lateral fissure to the center of amygdaloid body separately, the vertical diameter, the transversal diameter, and the anteroposterior diameter of the amygdaloid body and the 2 approach angles between the median sagittal plane and the shortest segment from the superior temporal sulcus to the center of amygdaloid body and the shortest segment from lateral fissure to the center of the amygdaloid body. At the same time, we preliminarily oriented the 2 points of the superior temporal sulcus and the lateral fissure, which are closest to the center of amygdaloid body, aimed at finding out the best entrance points of surgical approach through the superior temporal sulcus and the lateral fissure to the amygdaloid body and reducing the damage to the nerve fibers or blood vessels during the operation. The results indicate that the point at the front side 1/4 of the superior temporal sulcus may be the ideal surgical approach entrance point and the point at the front side 1/3 of the lateral fissure. There is no difference between 2 cerebral hemispheres (P < 0.05).

  14. Prognostic significance of clinical, morphological and molecular-genetic characteristics of larynx cancer, medic rehabilitation, quantitative estimation of the functional impairments extent for the purposes of expert-rehabilitative diagnostics

    Directory of Open Access Journals (Sweden)

    S. B. Shakhsuvaryan

    2016-01-01

    Full Text Available There have been presented a morphological classification and TNM international classification of a larynx cancer, distribution of malignant neoplasms of a given localization by stages considering the TNM parameters. There has been given a clinical characteristic of the disease depending on the process localization. There have been described the peculiarities of diagnostics and treatment as well as clinical, morphological and molecular-genetic prognostic factors. The main tasks and possibilities of medical rehabilitation of a given patients’ contingent have been shown including preservation of the larynx functions by means of reconstructive-restorative operations and the methods of the voice functions restoration after laryngectomia performing as well. There have been established the criteria of the functional impairments manifestation extent evaluation and there has been given stage-by-stage assessment of an extent of the body functions impairment in the larynx cancer in percent.

  15. Body Mass Index in Clinic Attenders: Patient Self-Perception versus Actual Measurements

    Directory of Open Access Journals (Sweden)

    S. Pooransingh

    2014-01-01

    Full Text Available Objectives. The objectives of the study were to measure actual BMI in patients attending chronic disease clinics in health centres and to relate this to the patients’ own perceptions of their body image and the need to lose weight. Study Design. A cross sectional study. Methods. The actual BMIs in patients who attended chronic disease clinics in 14 health centres were measured. All participants were asked to state where they thought they were on a visual body image scale and were also asked if they thought they needed to lose weight. Results. All participants approached agreed to participate (RR 100%. 70% of patients were found to have a raised BMI. Approximately 73% of patients using the visual scale indicated that an overweight or obese BMI was ideal for them. Conclusions. Patients think they are thinner than they actually are, with obvious implications for health and health seeking behaviour. A whole of society approach is needed to change weight status perceptions and improve exercise and dietary behaviour.

  16. Clinical approach to discoloration in body hair in a Rottweiler dog

    Directory of Open Access Journals (Sweden)

    Or M.E.

    2005-01-01

    Full Text Available Micanfin (Biocan-M®, Bioveta is a new veterinary drug used successfully in the treatment and prophylaxis of dermetomycosis in dogs and cats. In this study, leukotrichia was determined after administration of Micanfin and the objective was to determine the diagnosis and treatment protocol of the case. The case was a male Rottweiler dog, aged four, weighing 35 kg, presented with alopecia at a special veterinary clinic. A routine clinical examination, skin scraping, and antibiogram-mycologic examination of the body fluids were performed. A hematological examination and the levels of some serum parameters were determined. At the end of mycologic examinations, while there was no reproduction, it was found that the serum zinc level was very low. It was detected after other laboratory examinations that the case was hypothyroidism. All the body hair, except for a small area locally returned to the original colour, decreased activity reported by the animal owner disappeared at the end of the zinc applications and the treatment performed for the hypothyroidism (Biocan-M®. In conclusion, it was determined that the Micanfin vaccine application had not caused any side effects such as leukotrichia and the case was hypothyroidism.

  17. Clinical and ethical orientations in case of accidental ingestion of foreign body during dental treatment

    Directory of Open Access Journals (Sweden)

    Rhonan Ferreira da Silva

    2010-07-01

    Full Text Available Introduction:The passage of foreign bodies through the oropharynx during dental treatment is an accident that can be avoided in most cases,especially when the dentist adopts preventive measures such as using rubber dam or tying certain objects with dental floss. Objective:To emphasize the importance of avoiding the accident of ingesting foreign bodies during dental treatment and to guide the dentist on how to proceed,clinically and ethically, if the accident occurs.Case report:A minor female patient, unaccompanied,accidentally ingested a bur used for finishing a composite resin restoration during a dental treatment performed in the public service, due to a defect in the high-speed handpiece.The patient and their parents were informed of the accident,and the object was monitored radiographically until its elimination by natural means,with no reports of discomfort.Conclusion:It is the responsibility of the dentist to know and follow the necessary measures to avoid or solve complications from ingesting foreign bodies, since patient’s health and integrity must be protected. In addition, the dentist will also avoid possible ethical and legal demands when fulfilling his responsibilities as a health care professional.

  18. Synchrotron soft X-ray imaging and fluorescence microscopy reveal novel features of asbestos body morphology and composition in human lung tissues

    Directory of Open Access Journals (Sweden)

    Polentarutti Maurizio

    2011-02-01

    Full Text Available Abstract Background Occupational or environmental exposure to asbestos fibres is associated with pleural and parenchymal lung diseases. A histopathologic hallmark of exposure to asbestos is the presence in lung parenchyma of the so-called asbestos bodies. They are the final product of biomineralization processes resulting in deposition of endogenous iron and organic matter (mainly proteins around the inhaled asbestos fibres. For shedding light on the formation mechanisms of asbestos bodies it is of fundamental importance to characterize at the same length scales not only their structural morphology and chemical composition but also to correlate them to the possible alterations in the local composition of the surrounding tissues. Here we report the first correlative morphological and chemical characterization of untreated paraffinated histological lung tissue samples with asbestos bodies by means of soft X-ray imaging and X-Ray Fluorescence (XRF microscopy, which reveals new features in the elemental lateral distribution. Results The X-ray absorption and phase contrast images and the simultaneously monitored XRF maps of tissue samples have revealed the location, distribution and elemental composition of asbestos bodies and associated nanometric structures. The observed specific morphology and differences in the local Si, Fe, O and Mg content provide distinct fingerprints characteristic for the core asbestos fibre and the ferruginous body. The highest Si content is found in the asbestos fibre, while the shell and ferruginous bodies are characterized by strongly increased content of Mg, Fe and O compared to the adjacent tissue. The XRF and SEM-EDX analyses of the extracted asbestos bodies confirmed an enhanced Mg deposition in the organic asbestos coating. Conclusions The present report demonstrates the potential of the advanced synchrotron-based X-ray imaging and microspectroscopy techniques for studying the response of the lung tissue to the

  19. Human thermoregulation and measurement of body temperature in exercise and clinical settings.

    Science.gov (United States)

    Lim, Chin Leong; Byrne, Chris; Lee, Jason Kw

    2008-04-01

    This review discusses human thermoregulation during exercise and the measurement of body temperature in clinical and exercise settings. The thermoregulatory mechanisms play important roles in maintaining physiological homeostasis during rest and physical exercise. Physical exertion poses a challenge to thermoregulation by causing a substantial increase in metabolic heat production. However, within a non-thermolytic range, the thermoregulatory mechanisms are capable of adapting to sustain physiological functions under these conditions. The central nervous system may also rely on hyperthermia to protect the body from "overheating." Hyperthermia may serve as a self-limiting signal that triggers central inhibition of exercise performance when a temperature threshold is achieved. Exposure to sub-lethal heat stress may also confer tolerance against higher doses of heat stress by inducing the production of heat shock proteins, which protect cells against the thermolytic effects of heat. Advances in body temperature measurement also contribute to research in thermoregulation. Current evidence supports the use of oral temperature measurement in the clinical setting, although it may not be as convenient as tympanic temperature measurement using the infrared temperature scanner. Rectal and oesophagus temperatures are widely accepted surrogate measurements of core temperature (Tc), but they cause discomfort and are less likely to be accepted by users. Gastrointestinal temperature measurement using the ingestible temperature sensor provides an acceptable level of accuracy as a surrogate measure of Tc without causing discomfort to the user. This form of Tc measurement also allows Tc to be measured continuously in the field and has gained wider acceptance in the last decade.

  20. Clinical correlation of radiological spinal stenosis after standardization for vertebral body size

    International Nuclear Information System (INIS)

    Aim: To determine the relationship between the degree of radiographic lumbar spinal stenosis, adjusted with an internal control for vertebral body size, and disability from lumbar stenosis. Materials and methods: one hundred and twenty-three consecutive patients with clinical and radiological confirmation of neural impingement secondary to lumbar stenosis were enrolled prospectively. Thecal sac anteroposterior (AP) diameter (TSD) and cross-sectional area (CSA), and vertebral body AP dimension (VBD) were determined. These parameters were then correlated with patients' symptoms using the modified Roland-Morris questionnaire (RMQ) disability score. Results: No statistically significant inverse correlation was found between the TSD and RMQ score (p = 0.433), between the CSA and RMQ score (p = 0.124), or between the TSD:VBD ratio and RMQ score (p = 0.109). There was a significant positive correlation between the CSA:VBD ratio and RMQ score (p = .036), and therefore, there was no statistical support for an inverse relationship between the two. There was a significant difference in mean RMQ scores when the patients were divided into those with CSA greater than or equal to 70 mm2 and those less than 70 mm2, with T = -2.104 and p = 0.038. Conclusion: The degree of radiographic lumbar spinal stenosis, even with the use of an internal control of vertebral body size and standardized disability questionnaires, does not correlate with clinical symptoms. However, patients with more severe stenosis below a CSA critical threshold of 70 mm2, have significantly greater functional disability

  1. Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria.

    Science.gov (United States)

    Gisslinger, H; Jeryczynski, G; Gisslinger, B; Wölfler, A; Burgstaller, S; Buxhofer-Ausch, V; Schalling, M; Krauth, M-T; Schiefer, A-I; Kornauth, C; Simonitsch-Klupp, I; Beham-Schmid, C; Müllauer, L; Thiele, J

    2016-05-01

    Essential thrombocythemia (ET) is currently diagnosed either by the British Committee of Standards in Haematology (BCSH) criteria that are predominantly based on exclusion and not necessarily on bone marrow (BM) morphology, or the World Health Organization (WHO) criteria that require BM examination as essential criterion. We studied the morphological and clinical features in patients diagnosed according either to the BCSH (n=238) or the WHO guidelines (n=232). The BCSH-defined ET cohort was re-evaluated by applying the WHO classification. At presentation, patients of the BCSH group showed significantly higher values of serum lactate dehydrogenase and had palpable splenomegaly more frequently. Following the WHO criteria, the re-evaluation of the BCSH-diagnosed ET cohort displayed a heterogeneous population with 141 (59.2%) ET, 77 (32.4%) prefibrotic primary myelofibrosis (prePMF), 16 (6.7%) polycythemia vera and 4 (1.7%) primary myelofibrosis. Contrasting WHO-confirmed ET, the BCSH cohort revealed a significant worsening of fibrosis-free survival and prognosis. As demonstrated by the clinical data and different outcomes between WHO-diagnosed ET and prePMF, these adverse features were generated by the inadvertent inclusion of prePMF to the BCSH group. Taken together, the diagnosis of ET without a scrutinized examination of BM biopsy specimens will generate a heterogeneous cohort of patients impairing an appropriate clinical management. PMID:26710883

  2. Comorbidity between obsessive-compulsive disorder and body dysmorphic disorder: prevalence, explanatory theories, and clinical characterization

    Directory of Open Access Journals (Sweden)

    Frías Á

    2015-08-01

    Full Text Available Álvaro Frías,1,2 Carol Palma,1,2 Núria Farriols,1,2 Laura González2 1FPCEE Blanquerna, Universitat Ramon Llull, Barcelona, 2Adult Outpatient Mental Health Center, Hospital de Mataró – CSdM, Mataró, Spain Background: With the advent of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, body dysmorphic disorder (BDD has been subsumed into the obsessive-compulsive disorders and related disorders (OCDRD category. Objective: We aimed to determine the empirical evidence regarding the potential relationship between BDD and obsessive-compulsive disorder (OCD based on the prevalence data, etiopathogenic pathways, and clinical characterization of patients with both disorders. Method: A comprehensive search of databases (PubMed and PsycINFO was performed. Published manuscripts between 1985 and May 2015 were identified. Overall, 53 studies fulfilled inclusion criteria. Results: Lifetime comorbidity rates of BDD–OCD are almost three times higher in samples with a primary diagnosis of BDD than those with primary OCD (27.5% vs 10.4%. However, other mental disorders, such as social phobia or major mood depression, are more likely among both types of psychiatric samples. Empirical evidence regarding the etiopathogenic pathways for BDD–OCD comorbidity is still inconclusive, whether concerning common shared features or one disorder as a risk factor for the other. Specifically, current findings concerning third variables show more divergences than similarities when comparing both disorders. Preliminary data on the clinical characterization of the patients with BDD and OCD indicate that the deleterious clinical impact of BDD in OCD patients is greater than vice versa. Conclusion: Despite the recent inclusion of BDD within the OCDRD, data from comparative studies between BDD and OCD need further evidence for supporting this nosological approach. To better define this issue, comparative studies between BDD, OCD, and social phobia

  3. Morphological, immunophenotypic and clinical characteristics of dogs with lymphocytic - plasmacytic duodenitis

    OpenAIRE

    Đorđević Milena; Krstić V.; Krstić N.; Vasiljević Maja; Ilić V.; Vučićević Ivana; Aleksić-Kovačević Sanja

    2012-01-01

    The most important morphological feature of the immune response in lymphocytic-plasmacytic duodenitis (LPD) in dogs is the presence of a mononuclear infiltrate in the duodenal mucosa. The ethiopatogenesis of this disease is still unknown, nor are known all the immunophenotypic characteristics of the infiltrate cells, which would be of help in the elucidation of the pathogenesis of LPD. The study involved 60 adult dogs of different breeds and both sexes: 54 ...

  4. Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial

    Directory of Open Access Journals (Sweden)

    Evans Ellen M

    2012-06-01

    Full Text Available Abstract Limited data on sex differences in body composition changes in response to higher protein diets (PRO compared to higher carbohydrate diets (CARB suggest that a PRO diet helps preserve lean mass (LM in women more so than in men. Objective To compare male and female body composition responses to weight loss diets differing in macronutrient content. Design Twelve month randomized clinical trial with 4mo of weight loss and 8mo weight maintenance. Subjects Overweight (N = 130; 58 male (M, 72 female (F; BMI = 32.5 ± 0.5 kg/m2 middle-aged subjects were randomized to energy-restricted (deficit ~500 kcal/d diets providing protein at 1.6 g.kg-1.d-1 (PRO or 0.8 g.kg-1.d-1 (CARB. LM and fat mass (FM were measured using dual X-ray absorptiometry. Body composition outcomes were tested in a repeated measures ANOVA controlling for sex, diet, time and their two- and three-way interactions at 0, 4, 8 and 12mo. Results When expressed as percent change from baseline, males and females lost similar amounts of weight at 12mo (M:-11.2 ± 7.1 %, F:-9.9 ± 6.0 %, as did diet groups (PRO:-10.7 ± 6.8 %, CARB:-10.1 ± 6.2 %, with no interaction of gender and diet. A similar pattern emerged for fat mass and lean mass, however percent body fat was significantly influenced by both gender (M:-18.0 ± 12.8 %, F:-7.3 ± 8.1 %, p  Conclusion PRO was more effective in reducing percent body fat vs. CARB over 12mo weight loss and maintenance. Men lost percent total body fat and trunk fat more effectively than women. No interactive effects of protein intake and gender are evident.

  5. WHO-defined Classification of Myeloproliferative Neoplasms: Morphological Reproducibility and Clinical Correlations - The Danish Experience

    DEFF Research Database (Denmark)

    Madelung, AB; Stamp, IMH; Nielsen, SL;

    2013-01-01

    We examined inter- and intraobserver reproducibility and concordance between histological diagnosis and independently collected clinical findings in a large series of patients with the major subtypes of myeloproliferative neoplasms (MPNs) and controls. Seven hematopathologists reviewed 272 bone...

  6. Fixation patterns, not clinical diagnosis, predict body size over‐estimation in eating disordered women and healthy controls

    Science.gov (United States)

    Cornelissen, Katri K.; Cornelissen, Piers L.; Hancock, Peter J. B.

    2016-01-01

    ABSTRACT Objective A core feature of anorexia nervosa (AN) is an over‐estimation of body size. Women with AN have a different pattern of eye‐movements when judging bodies, but it is unclear whether this is specific to their diagnosis or whether it is found in anyone over‐estimating body size. Method To address this question, we compared the eye movement patterns from three participant groups while they carried out a body size estimation task: (i) 20 women with recovering/recovered anorexia (rAN) who had concerns about body shape and weight and who over‐estimated body size, (ii) 20 healthy controls who had normative levels of concern about body shape and who estimated body size accurately (iii) 20 healthy controls who had normative levels of concern about body shape but who did over‐estimate body size. Results Comparisons between the three groups showed that: (i) accurate body size estimators tended to look more in the waist region, and this was independent of clinical diagnosis; (ii) there is a pattern of looking at images of bodies, particularly viewing the upper parts of the torso and face, which is specific to participants with rAN but which is independent of accuracy in body size estimation. Discussion Since the over‐estimating controls did not share the same body image concerns that women with rAN report, their over‐estimation cannot be explained by attitudinal concerns about body shape and weight. These results suggest that a distributed fixation pattern is associated with over‐estimation of body size and should be addressed in treatment programs. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:507–518). PMID:26996142

  7. Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives.

    Science.gov (United States)

    Staff, Synnöve; Kujala, Paula; Karhu, Ritva; Rökman, Annika; Ilvesaro, Joanna; Kares, Saara; Isola, Jorma

    2013-09-01

    Formalin fixation preserves tissue morphology at the expense of macromolecule integrity. Freshly frozen samples are the golden standard for DNA and RNA analyses but require laborious deep-freezing and frozen sectioning for morphological studies. Alternative tissue stabilisation methods are therefore needed. We analysed the preservation of nucleic acids, immunohistochemical staining properties and tissue morphology in paraffin-embedded clinical tissue samples fixed with Z7, RCL2, PAXgene, Allprotect and RNAlater. Formalin-fixed and deep-frozen samples were used as controls. Immunohistochemical analyses showed good preservation of antigenicity in all except Allprotect and RNAlater-fixed samples. RNA quality, based on RNA integrity number value by Bioanalyzer, was comparable with freshly frozen samples only in PAXgene-fixed samples. According to quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses, RNA from PAXgene samples yielded results similar to freshly frozen samples. No difference between fixatives was seen in DNA analyses (PCR and real-time PCR). In conclusion, PAXgene seems to be superior to other molecular fixatives and formaldehyde.

  8. Morphological changes of condyles and Helkimo clinical dysfunction index in patients treated with Herbst--orthodontic appliance.

    Science.gov (United States)

    Aidar, Luís Antônio de Arruda; Abrahão, Márcio; Yamashita, Hélio K; Dominguez, Gladys Cristina

    2013-01-01

    This study evaluated the morphological changes in the temporomandibular joint (TMJ) condyles and calculated the Helkimo clinical dysfunction index (CDI) in adolescents with Class II Division 1 malocclusion and mandibular retrognathism treated with the Herbst appliance (phase I) and fixed orthodontic appliances (phase II). Thirty-two consecutive adolescents underwent phase I, and 23 completed phase II. The TMJs were evaluated qualitatively using magnetic resonance imaging (MRI) at the beginning of treatment (T1), during phase I (T2), at the end of phase I (T3) and at the end of phase II (T4). The CDI was calculated at T1, T3 and T4. From T1 to T3 (p=0.326), there were no changes in condyle morphology in 86.0% of the TMJs. From T3 to T4 (p<0.05) and T1 to T4 (p<0.05), changes occurred in 39.1% and 43.4% of the condyles. No significant changes in CDI occurred from T1 to T3, T3 to T4 and T1 to T4 (p=1.000; 86.6%, 76.2% and 76.2% concordance). After phase I, there were practically no changes in condyle morphology. At the end of phase II, a mild flattening was observed in some condyles. It may be concluded that no significant changes occurred in CDI after both treatment phases.

  9. Temporal and morphological differences in post-embryonic differentiation of the mushroom bodies in the brain of workers, queens, and drones of Apis mellifera (Hymenoptera, Apidae).

    Science.gov (United States)

    Roat, Thaisa Cristina; da Cruz Landim, Carminda

    2008-12-01

    The mushroom bodies are structures present in the insect brain described as centers for the neural basis of learning, memory, and other higher functions. Honeybees (Apis mellifera) are insects with a sophisticated system of spatial orientation and possess well-developed learning and memory capabilities, which are associated with neural and brain structures. Thus, the present study aimed to compare the mushroom bodies during post-embryonic development and in newly emerged males, workers, and queens using light and transmission electron microscopy to examine how differential morphological characteristics are established during development. Measurements of structures were also taken in several post-embryonic developmental phases in order to evaluate size differences during the process and in the adult organs. The results show that workers, queens, and males exhibit temporal and size differences during the post-embryonic development of mushroom bodies, probably as adaptations to differences in behavior complexity. The mushroom bodies of workers are precociously formed and are larger than those of queens and drones. Thus, workers have the largest mushroom bodies resulting from differential development during metamorphosis.

  10. A novel method for the measurement of linear body segment parameters during clinical gait analysis.

    Science.gov (United States)

    Geil, Mark D

    2013-09-01

    Clinical gait analysis is a valuable tool for the understanding of motion disorders and treatment outcomes. Most standard models used in gait analysis rely on predefined sets of body segment parameters that must be measured on each individual. Traditionally, these parameters are measured using calipers and tape measures. The process can be time consuming and is prone to several sources of error. This investigation explored a novel method for rapid recording of linear body segment parameters using magnetic-field based digital calipers commonly used for a different purpose in prosthetics and orthotics. The digital method was found to be comparable to traditional in all linear measures and data capture was significantly faster with the digital method, with mean time savings for 10 measurements of 2.5 min. Digital calipers only record linear distances, and were less accurate when diameters were used to approximate limb circumferences. Experience in measuring BSPs is important, as an experienced measurer was significantly faster than a graduate student and showed less difference between methods. Comparing measurement of adults vs. children showed greater differences with adults, and some method-dependence. If the hardware is available, digital caliper measurement of linear BSPs is accurate and rapid.

  11. Morphological variation and mathematical analysis of effects of morphological traits on body-weight of GIFT tilapia after 3 generations of breeding%吉富罗非鱼家系选育3代后形态性状变异及其对体质量的影响

    Institute of Scientific and Technical Information of China (English)

    李灵玲; 董在杰; 苏胜彦; 徐跑; 梁政远; 马良骁; 刘伟; 张建桥

    2012-01-01

    GIFT strain of Nile tilapia (Oreochromis niloticus) played an important role in world fishery. Several researches indicated that the growth performance of GIFT can still be improved. As an important indicator of breeding, body-weight was influenced by many morphological traits, and morphological traits that impact offspring body-weight might be changed after breeding, so comparative analyses of the impacts of morphological traits on body-weight between the offspring and parental generation became necessary. Sixty families of GIFT were introduced into FFRC as the parents (P) in 2006 for further study, three generations of offspring were bred (F1, F2, F3). In order to observe the achievement of breeding, body- weight (Y), body-length (X1), body-thickness (X2) and body-height (X3) of the P and F3 were measured, variation of four morphological traits of P and F3 were analyzed; correlation analysis, path analysis and regression analysis were used to calculate the correlation coefficient, path coefficient and the coefficient of determination, and the multiple regression equations between body-weighty) and morphological traits(X1, X2, X3)were established and analyzed. Results showed that: 1) compared with P, body-weight, body-length and body-thickness of F3 had a significant increase (P<0.01), meanwhile a certain decline in the coefficient of variation (CV) was observed, body size of tilapia of F3 showed a trend of being consistent. Male of F3had increased in some degree, significant increase of 4 traits of the male group was not observed. 2) Trait affected the body-weight most of F3 converted to body-length, which was body-height x body-length in P. 3) The influence of body-length, body-thickness and body-height on body-weight declined more in F3 than that in P. Results above indicated that, breeding made a positive effect on the growth speed of GIFT; for further study we should be more careful in selecting morphological traits, and some other morphological traits which

  12. Tongue diagnosis:relationship between sublingual tongue morphology in three tongue protrusion angles and menstrual clinical symptoms

    Institute of Scientific and Technical Information of China (English)

    Tim Hideaki Tanaka

    2015-01-01

    OBJECTIVE:The morphological and color characteristics of the tongue sublingual veins (SLVs) can manifest differently within the subjects, depending on the way their tongue is curled upward. This study was conducted in order to investigate the clinical relevancy of tongue SLV diagnosis in relation to menstrual clinical symptoms (pain, clots, heavy, and scanty), using three different inspection procedures (IP1, IP2, and IP3). METHODS: Three-hundred and seventy-seven female patients were asked to stick out their tongues in three speciifc ways which were intended to create different tongue protrusion angles. The SLV parameters for thickness (TK), length (LE), color (CL), shape (SP), and nodules (ND) were then evaluated. RESULTS: According to the results of the Waldχ2 test, IP1 provides the best model for pain (R2 = 0.155), IP3 for clots (R2 = 0.437), IP2 for heavy (R2 = 0.268), and scanty (R2 = 0.192). Abnormal SLV diagnostic parameters were most strongly associated with the clinical symptom of clots (R2= 0.492). CONCLUSION: While the study showed the relations between tongue SLV features and menstrual clinical symptoms, as wel it showed that IP2 was the best overal predictor for the symptomatic indexes used in this study, and using one particular SLV inspection procedure may not be sufifcient. The application of a particular inspection method alone may cause under- or over-estimation of SLV abnormalities.

  13. Evolutionary history of Chaetognatha inferred from molecular and morphological data: a case study for body plan simplification

    OpenAIRE

    Gasmi, Samah; Nève, Gabriel; Pech, Nicolas; Tekaya, Saïda; Gilles, André; Perez, Yvan

    2014-01-01

    International audience Background: Chaetognatha are a phylum of marine carnivorous animals which includes more than 130 extant species. The internal systematics of this group have been intensively debated since it was discovered in the 18(th) century. While they can be traced back to the earlier Cambrian, they are an extraordinarily homogeneous phylum at the morphological level - a fascinating characteristic that puzzled many a scientist who has tried to clarify their taxonomy. Recent stud...

  14. Evolutionary history of Chaetognatha inferred from molecular and morphological data: a case study for body plan simplification

    OpenAIRE

    Gasmi, Samah; Nève, Gabriel; Pech, Nicolas; Tekaya, Saïda; Gilles, André; Perez, Yvan

    2014-01-01

    Background Chaetognatha are a phylum of marine carnivorous animals which includes more than 130 extant species. The internal systematics of this group have been intensively debated since it was discovered in the 18th century. While they can be traced back to the earlier Cambrian, they are an extraordinarily homogeneous phylum at the morphological level - a fascinating characteristic that puzzled many a scientist who has tried to clarify their taxonomy. Recent studies which have attempted to r...

  15. Stereotactic Body Radiotherapy for Oligometastasis: Opportunities for Biology to Guide Clinical Management.

    Science.gov (United States)

    Correa, Rohann J M; Salama, Joseph K; Milano, Michael T; Palma, David A

    2016-01-01

    Oligometastasis refers to a state of limited metastatic disease burden, in which surgical or ablative treatment to all known visible metastases holds promise to extend survival or even effect cure. Stereotactic body radiotherapy is a form of radiation treatment capable of delivering a high biologically effective dose of radiation in a highly conformal manner, with a favorable toxicity profile. Enthusiasm for oligometastasis ablation, however, should be counterbalanced against the limited supporting evidence. It remains unknown to what extent (if any) ablation influences survival or quality of life. Rising clinical equipoise necessitates the completion of randomized controlled trials to assess this, several of which are underway. However, a lack of clear identification criteria or biomarkers to define the oligometastatic state hampers optimal patient selection.This narrative review explores the evolutionary origins of oligometastasis, the steps of the metastatic process at which oligometastases may arise, and the biomolecular mediators of this state. It discusses clinical outcomes with treatment of oligometastases, ongoing trials, and areas of basic and translational research that may lead to novel biomarkers. These efforts should provide a clearer, biomolecular definition of oligometastatic disease and aid in the accurate selection of patients for ablative therapies. PMID:27441744

  16. The clinical value of routine whole-body magnetic resonance imaging (MRI) in palliative care

    Energy Technology Data Exchange (ETDEWEB)

    Geitung, Jonn Terje (Department of Radiology, Haraldspass Deaconess (University) Hospital (Norway); Department of Surgical Sciences, University of Bergen (Norway)), Email: jtgeit@online.no; Eikeland, Joakim (Department of Public Health and Primary Health Care, University of Bergen (Norway)); Rosland, Jan Henrik (Department of Public Health and Primary Health Care, University of Bergen (Norway); Sunniva Clinic for Palliative Care, Haraldsplass Deaconess (University) Hospital (Norway))

    2012-03-15

    Background. Whole-body MRI (WBMRI) has become an accessible method for detecting different types of pathologies both in the skeleton and the viscera, which may explain painful conditions, for example tumors and inflammation. Purpose. To assess a possible value of using WBMRI in order to improve palliative care. Material and Methods. Twenty patients (all eligible patients) admitted to the Department for Palliative Care were consecutively included in this study. They underwent a modified WBMRI, with fewer and shorter pulse sequences than in a standard WBMRI, to reduce patient stress. However, the patients' physicians were to exclude patients where little might be obtained and discomfort, distress, and pain could be induced. The treating physicians registered clinical utility directly after receiving the MRI report in a questionnaire. The registration was repeated after ended treatment. Results. Eighty percent had new findings detected, and 40% of the patients had a change in treatment due to the MRI result, mainly changes in analgesics and/or radiation therapy. Conclusion. The WBMRI helped the clinicians to improve treatment and a majority of the patients benefited from this. In eight patients the treatment was changed due to the results. The clinical value (utility) was indicated to be high

  17. Clinical Characteristics and Remedies in 45 Iranians with Carotid Body Tumors

    Directory of Open Access Journals (Sweden)

    Javad Salimi

    2012-05-01

    Full Text Available Carotid body tumors (CBTs are rare, slow-growing tumors that should be considered in evaluating every lateral neck mass. This single center study was performed to define demographic features, clinical characteristics and remedies of Iranian patients with CBT. A retrospective review of prospectively collected data was done on 45 patients with 50 CBTs who have been referred to Sina Hospital, Tehran, Iran, during a 10-year period, were investigated in this study. The demographic characteristics, clinical and pathologic features, imagings, preoperative treatments, surgical approach and complications were analyzed. The study group predominantly consisted of females (82%. Age of diagnosis was 18 to 75 years old. Five patients had bilateral CBT. Family history of CBT was positive in seven patients. Most of CBTs were ≤ 3cm in size. All of the patients presented with a neck mass, mostly without pain (84%. Other symptoms included vertigo 4%, dysphasia 4% and tinnitus 2%. There was no patient with cranial nerve involvement at presentation. The most common imaging helping the diagnosis was color Doppler sonography. Three patients had preoperative embolization. All patients underwent surgery and seven patients had post-operative cranial nerve injury. Nine cases underwent external carotid artery ligation and four ones had external carotid repair. Post operative mortality rate was one patient. This study provides epidemiological data on patients with CBT in Iran, which could be useful for health care workers in prompt diagnosis and appropriate work ups for patient's families in bilateral CBTs.

  18. Worldwide, multicenter study of peristomal geometry and morphology in laryngectomees and its clinical effects

    NARCIS (Netherlands)

    van Kalkeren, Tjouwke A.; van der Houwen, Eduard B.; Duits, Mari Anne E.; Hilgers, Frans J.; Hebe, Ana; Mostafa, Badr E.; Lawson, George; Martinez, Zurine; Woisard, Virginie; Marioni, Gino; Ruske, Dean; Schultz, Philippe; Post, Wendy J.; Verkerke, Gijsbertus J.; van der Laan, Bernard F. A. M.

    2011-01-01

    Background. The purpose of this study was to improve attachment of automatic tracheostoma valves, the knowledge on tracheostoma geometry, and its clinical influences preferred. This article investigates whether the number of removed trachea rings, incision of the sternocleidomastoid muscles, neck di

  19. Allometric body shape changes and morphological differentiation of Shemaya, Alburnus chalcoides (Guldenstadf, 1772, populations in the southern part of Caspian Sea using Elliptic Fourier analysis

    Directory of Open Access Journals (Sweden)

    Mohammad Mohadasi

    2014-09-01

    Full Text Available Study of phenotypic diversity among populations can help better understanding of diversification of species within ecosystems and intraspecific diversification in fishes. A geometric morphometric study was carried out using the Elliptic Fourier analysis to demonstrate the effect of habitat type on morphological features of shemaya (Alburnus chalcoides populations. Populations were sampled from three rivers and one lagoon, from the southern part of Caspian Sea. Significant differences in body shape were found among the populations. Differences in shapes of the riverine populations were minute compared to those of lagoon one in terms of size and shape. Shemaya is an anaderemus fish and its populations have a common origin, therefore, observed differences could be as result of environmental factors. In addition, this study suggest that the amount of curvature i.e. fusiform body shape of this species could be independent form environmental condition.

  20. Irritable bowel syndrome subtypes: clinical and psychological features, body mass index and comorbidities

    Directory of Open Access Journals (Sweden)

    Cristiane Kibune-Nagasako

    2016-02-01

    Full Text Available Background: Irritable bowel syndrome (IBS is classified into subtypes according to bowel habit. Objective: To investigate whether there are differences in clinical features, comorbidities, anxiety, depression and body mass index (BMI among IBS subtypes. Methods: The study group included 113 consecutive patients (mean age: 48 ± 11 years; females: 94 with the diagnosis of IBS. All of them answered a structured questionnaire for demographic and clinical data and underwent upper endoscopy. Anxiety and depression were assessed by the Hospital Anxiety and Depression scale (HAD. Results: The distribution of subtypes was: IBS-diarrhea (IBS-D, 46%; IBS-constipation (IBS-C, 32%, and mixed IBS (IBS-M, 22%. IBS overlap with gastroesophageal reflux disease (GERD, functional dyspepsia, chronic headache and fibromyalgia occurred in 65.5%, 48.7%, 40.7% and 22.1% of patients, respectively. Anxiety and/or depression were found in 81.5%. Comparisons among subgroups showed that bloating was significantly associated with IBS-M compared to IBS-D (odds ratio-OR-5.6. Straining was more likely to be reported by IBS-M (OR 15.3 and IBS-C (OR 12.0 compared to IBS-D patients, while urgency was associated with both IBS-M (OR 19.7 and IBS-D (OR 14.2 compared to IBS-C. In addition, IBS-M patients were more likely to present GERD than IBS-D (OR 6.7 and higher scores for anxiety than IBS-C patients (OR 1.2. BMI values did not differ between IBS-D and IBS-C. Conclusion: IBS-M is characterized by symptoms frequently reported by both IBS-C (straining and IBS-D (urgency, higher levels of anxiety, and high prevalence of comorbidities. These features should be considered in the clinical management of this subgroup.

  1. Volumetric intensity modulated arc therapy for stereotactic body radiosurgery in oligometastatic breast and gynecological cancers: feasibility and clinical results.

    Science.gov (United States)

    Macchia, Gabriella; Deodato, Francesco; Cilla, Savino; Torre, Gabriella; Corrado, Giacomo; Legge, Francesco; Gambacorta, Maria Antonietta; Tagliaferri, Luca; Mignogna, Samantha; Scambia, Giovanni; Valentini, Vincenzo; Morganti, Alessio G; Ferrandina, Gabriella

    2014-11-01

    In the present study, the preliminary results of the first stereotactic body radiosurgery (SRS) experience with volumetric intensity modulated arc therapy (VMAT) in oligometastatic breast and recurrent gynecological tumors (OBRGT) are reported in terms of feasibility, toxicity and efficacy. Patients were treated in a head-first supine treatment position on a customized body frame immobilization shell. SRS-VMAT treatment plans were optimized using the ERGO++ treatment planning system. Response assessment was performed 8-12 weeks after treatment by morphologic imaging modalities, or if feasible, also by functional imaging. Thirty-six lesions in 24 consecutive patients (median age, 63 years; range, 40-81) were treated: 13.9% had primary or metastatic lung lesions, 30.5% had liver metastases, 36.1% had bone lesions, 16.7% had lymph node metastases and 2.8% had a primary vulvar melanoma. The median dose was 18 Gy (BED2 Gy, α/β: 10=50.4 Gy), the minimal dose was 12 Gy (BED2 Gy, α/β: 10=26.4 Gy) and the maximal dose was 28 Gy (BED2 Gy, α/β: 10=106.4 Gy). Seven patients (29.2%) experienced acute toxicity, which however was grade 2 in only 1 case. Moreover, only 3 patients (12.5%) developed late toxicity of which only 1 was grade 2. Objective response rate was 77.7% including 16 lesions achieving complete response (44.4%) and 12 lesions achieving partial response (33.3%). The median duration of follow-up was 15.5 months (range, 6-50). Recurrence/progression within the SRS-VMAT treated field was observed in 6 patients (total lesions=7) with a 2-year inside SRS-VMAT field disease control expressed on a per lesion basis of 69%. Recurrence/progression of disease outside the SRS-VMAT field was documented in 15 patients; the 2-year outside SRS-VMAT field metastasis‑free survival, expressed on a per patient basis, was 35%. Death due to disease was documented in 6 patients and the 2-year overall survival was 58%. Although the maximum tolerated dose was

  2. Squamous cell carcinoma of the tongue: clinical and morphological analysis of 57 cases and correlation with prognosis

    Directory of Open Access Journals (Sweden)

    Marcelo Gadelha Vasconcelos

    2014-10-01

    Full Text Available Introduction: Oral squamous cell carcinoma (OSCC, which represents more than 90% of head and neck malignant neoplasms, has a poor prognosis due to its high frequency of lymph node metastasis and local invasion. Previous studies have investigated parameters related to the biological behavior of OSCC and its correlation with disease outcome (DO. Objective: To evaluate clinical and morphological data in cases of tongue squamous cell carcinoma (TSCC, correlating these findings with prognosis. Material and methods: Fifty-seven specimens of TSCC were obtained from patients undergoing surgical excision at a referral hospital in Natal, Brazil. Clinical data, such as tumor-node-metastasis (TNM stage and DO, were collected from medical records. Hematoxylin and eosin-stained sections were analyzed regarding histological grade of malignancy (HGM, based on the system proposed by Bryne (1998 Results: The majority of patients (38.6% were diagnosed as TNM stage III, and 57.9% developed metastases. Remission of the tumor occurred in 77.2% of the cases. The parameter “metastasis” exhibited a significant association with DO (p = 0 and TNM stage (p = 0.001, thus constituting a good indicator of tumor progression. Correlation of HGM and TNM stage with DO was not evidenced. Nevertheless, statistical analysis showed a significant association between HGM and TNM stage (p = 0.006. Conclusion: TNM clinical staging and HGM, evaluated in association, may be useful to estimate the prognosis of TSCC.

  3. Clinical, endoscopical and morphological efficacy of mesalazine in patients with irritable bowel syndrome

    Directory of Open Access Journals (Sweden)

    Dorofeyev AE

    2011-06-01

    Full Text Available Andrey E Dorofeyev1, Elena A Kiriyan2, Inna V Vasilenko1, Olga A Rassokhina1, Andrey F Elin11National Medical University, Donetsk, Ukraine; 2Gastroenterological Center of Poltava Hospital Clinic, Poltava, UkraineObjectives: The aim of this study was to analyze the clinical efficacy and cytomorphologic changes of colon mucosa following the treatment of patients suffering from irritable bowel syndrome (IBS with mesalazine (5-aminosalicylic acid [5-ASA].Methods: In this controlled, randomized, blind clinical trial, a total of 360 patients with varying subtypes of IBS were randomly treated with 500 mg of mesalazine qid or by standard therapy without mesalazine for a period of 28 days. Pre- and post-treatment pain intensity, pain duration, meteorism, stool abnormalities and endoscopic parameters were monitored, and biopsies or brush biopsies were examined histologically.Results: Treatment of IBS patients with mesalazine significantly reduced intensity and duration of pain in all subtypes of IBS, except for duration of pain in the subtype “undifferentiated”, where the difference was not significant. In addition, in patients with diarrhea type and undifferentiated type of IBS, mesalazine also significantly reduced the abnormal stool pattern. In comparison to the control group, administration of mesalazine reduced the incidence of endoscopic and cytomorphologic changes of the bowel mucosa, including changes in colon mucus, mucus production, cytologic or histologic parameters, epithelial cell degeneration, appearance of leukocytes and macrophages and cell infiltrations.Conclusion: Mesalazine was effective in reducing several symptoms characteristic of IBS. It significantly reduced pain intensity and duration and improved cytohistologic parameters of the bowel mucosa.Keywords: 5-amino salicylic acid, 5-ASA, abdominal pain, irritable bowel syndrome, IBS, meteorism, stool abnormalities

  4. Clinical Characteristics and Management of Late Urinary Symptom Flare Following Stereotactic Body Radiation Therapy for Prostate Cancer

    OpenAIRE

    Woo, Jennifer A; Leonard N Chen; Bhagat, Aditi; Oermann, Eric K; Kim, Joy S; Moures, Rudy; Yung, Thomas; Lei, Siyuan; Collins, Brian T.; Kumar, Deepak; Suy, Simeng; Dritschilo, Anatoly; Lynch, John H.; Sean P Collins

    2014-01-01

    Purpose: Stereotactic body radiation therapy (SBRT) is increasingly utilized as primary treatment for clinically localized prostate cancer. While acute post-SBRT urinary symptoms are well recognized, the late genitourinary toxicity of SBRT has not been fully described. Here, we characterize the clinical features of late urinary symptom flare and recommend conservative symptom management approaches that may alleviate the associated bother. Methods: Between February 2008 and August 2011, 216...

  5. Prevalence of body dysmorphic disorder in patients referred to Razi hospital cosmetic clinic with complaints of cosmetic disorders

    OpenAIRE

    Amirhooshang Ehsani; Yousef Fakour; Fatemeh Gholamali; Leila Mokhtari; Mahbobeh Sadat Hosseini; Najmeh Khosrovanmehr; Pedram Noormohammadpour

    2013-01-01

    Background: Body dysmorphic disorder (BDD) is characterized by a preoccupation with an imagined defect in ones appearance or an exaggeration of a slight physical anomaly. Any part of the appearance may be the focuse of BDD patients. Thus preoccupation with appearance leads to significant damages of social and job functioning. The aim of this study is to determine the prevalence of BDD in patients referred to cosmetic clinic of Razi hospital.Methods: Patients visiting cosmetic clinic of Razi h...

  6. A Novel Glycinate-based Body Wash: Clinical Investigation Into Ultra-mildness, Effective Conditioning, and Improved Consumer Benefits

    OpenAIRE

    Regan, Jamie; Mollica, Leonel-Maximo; Ananthapadmanabhan, K.P.

    2013-01-01

    Objective: To assess the properties of a novel body wash containing the mild surfactant glycinate. Design: Biochemical and clinical assays. Setting: Research laboratories and clinical sites in the United States and Canada. Participants: Women 18 to 65 years of age (cleansing efficacy); male and female subjects 26 to 63 years of age with mild or moderate dryness and erythema (leg-controlled application test); subjects 5 to 65 years of age with mild-to-moderate eczema (eczema compatibility); an...

  7. Morphological features and associated anomalies of schizencephaly in the clinical population: detailed analysis of MR images

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, N. [Department of Radiology, Faculty of Medicine, University of Tokyo (Japan); Department of Radiology, Section of Neuroradiology, University of California San Francisco, CA (United States); Tsutsumi, Y. [Department of Radiology, National Okura Hospital, Tokyo (Japan); Barkovich, A.J. [Department of Radiology, Section of Neuroradiology, University of California San Francisco, CA (United States)

    2002-05-01

    Although they are well documented in autopsy series, the macroscopic features and associated anomalies of schizencephalies have not been described in detail in a large clinical population. To assess the macroscopic findings of schizencephaly and the prevalence of associated findings, we conducted a retrospective MR analysis of a group of patients with schizencephaly. The MR studies of 35 patients with schizencephaly were retrospectively reviewed. The images were examined for the location and size of the schizencephalic cleft, the presence and location of associated polymicrogyria, and the presence, location, and severity of other brain anomalies. A total of 54 schizencephalic clefts were seen in the 35 patients. These clefts were unilateral in 18 (51%) patients and bilateral in 17 (49%) patients; three clefts were identified in two patients. Nine clefts (17%) had fused lips and 45 had separated-lip clefts (83%). Polymicrogyria was present inside 23 clefts (43%), while subependymal heterotopias were present at the cleft orifice in 27 clefts (50%). Polymicrogyria was identified outside the cleft, both adjacent to and remote from the cleft, in 23 patients (66%). Abnormal cerebral white-matter signal intensity was present in seven patients (20%), while white-matter volume diminution was noted in all patients. Ventricular diverticula with mass effect, roofing membranes, remnant floors, and cord-like remnants were present in 12, 1, 11, and 3 patients, respectively. Our results show that the spectrum of macroscopic findings in schizencephaly includes fused-lip and separated-lip clefts, polymicrogyric and non-polymicrogyric cleft linings, cyst-like diverticula and membranous structures, and subependymal heterotopia at the cleft. Concomitant anomalies are polymicrogyria outside the cleft, white-matter diminution, septal and optic pathway anomalies, callosal anomalies and hippocampal anomalies. Unilateral and bilateral clefts occur in a nearly equal frequency in the clinical

  8. Biological Maturation, Body Morphology and Physical Performance in 8-16 Year-Old Obese Girls from Montes Claros – Mg

    Directory of Open Access Journals (Sweden)

    Freitas Alex S.

    2014-12-01

    Full Text Available Measurements of maturity depend on the biological system considered since differences are often found in performance and body size in subjects of the same chronological age. The objective of this study was to identify associations between biological maturation, body morphology and physical performance in girls aged from 8.0 to 15.9 year-old and to verify the bone age in obese girls and compare it with chronological age. For that purpose 2040 (11.9 ± 2.3 years school girls from Montes Claros, participated in this study. Regular anthropometric measures as height and body mass were taken. Triceps, biceps, subscapular, abdominal, suprailiac and calf skinfolds were also registered. Physical performance was assessed trough the test of a standing long jump, handgrip strength and 20 m multistage shuttle run. Maturational status, the average age at menarche and identification of PHV (maturity off set were determined by means of the retrospective method. Girls with the BMI above the 95th percentile got their bone age evaluated through X-ray of the left hand/wrist, in accordance with the FELS method. It was possible to find an average age at menarche of 11.30 ± 0.70, while the average age at PHV was 12.17 ± 0.71 years of age. It was observed that both body composition and physical performance showed a tendency to increase with advancing age. However, when controlling the effect of maturation, despite having higher values in body composition the post-menarche girls group did not show higher levels of physical performance. In all age groups, obese girls showed mean rates of bone age higher than chronologic age (12.25 ± 2.09 and 14.09 ± 2.35, respectively, p=0.000. Chronological age should be used with caution when evaluating obese teenagers as it may underestimate biological age.

  9. Initial Clinical Experience in Multiple Myeloma Staging by Means of Whole-Body Resonance Techniques

    International Nuclear Information System (INIS)

    To develop a magnetic resonance (MR) exploratory technique equivalent to serial bone X-ray, and to compare their precision in the staging of multiple myeloma (MM) patients. Multiple acquisition T1-weights TSE and STIR sequences in the coronal plane were performed. Ten healthy volunteers and 11 multiple myeloma diagnosed patients were included. The visualization of bony structures was particularly noted,with special attention given to those which would normally be included in a serial bone X-ray. In the case of the patients, a comparison was made between diagnostic capacities of the MR sequences. MR highlighters significantly more (p<0.05) bony elements than did the serial bone X-ray. This was greatly due to a sequential displacement of the scanner bed, allowing for field-of-views which were minimally from head to third proximal of the leg. Magnetic resonance detected a significantly higher number (p<0.05) of lesions. It was, in turn, capable of revealing greater lesion extensions, even to the point of implying staging classification changes in 18% of the patients. The utilization of whole-body MR techniques in multiple myeloma patients is feasible and clinically beneficial. MR is both more sensitive and more specific than serial bone X-ray for evaluation of bony lesions in MM. It is currently serving as a valid alternative in a growing numbers of patients. (Author) 10 refs

  10. Psychogenic fever: how psychological stress affects body temperature in the clinical population.

    Science.gov (United States)

    Oka, Takakazu

    2015-01-01

    Psychogenic fever is a stress-related, psychosomatic disease especially seen in young women. Some patients develop extremely high core body temperature (Tc) (up to 41°C) when they are exposed to emotional events, whereas others show persistent low-grade high Tc (37-38°C) during situations of chronic stress. The mechanism for psychogenic fever is not yet fully understood. However, clinical case reports demonstrate that psychogenic fever is not attenuated by antipyretic drugs, but by psychotropic drugs that display anxiolytic and sedative properties, or by resolving patients' difficulties via natural means or psychotherapy. Animal studies have demonstrated that psychological stress increases Tc via mechanisms distinct from infectious fever (which requires proinflammatory mediators) and that the sympathetic nervous system, particularly β3-adrenoceptor-mediated non-shivering thermogenesis in brown adipose tissue, plays an important role in the development of psychological stress-induced hyperthermia. Acute psychological stress induces a transient, monophasic increase in Tc. In contrast, repeated stress induces anticipatory hyperthermia, reduces diurnal changes in Tc, or slightly increases Tc throughout the day. Chronically stressed animals also display an enhanced hyperthermic response to a novel stress, while past fearful experiences induce conditioned hyperthermia to the fear context. The high Tc that psychogenic fever patients develop may be a complex of these diverse kinds of hyperthermic responses. PMID:27227051

  11. Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

    International Nuclear Information System (INIS)

    We recently developed a dynamic multi-bed PET data acquisition framework to translate the quantitative benefits of Patlak voxel-wise analysis to the domain of routine clinical whole-body (WB) imaging. The standard Patlak (sPatlak) linear graphical analysis assumes irreversible PET tracer uptake, ignoring the effect of FDG dephosphorylation, which has been suggested by a number of PET studies. In this work: (i) a non-linear generalized Patlak (gPatlak) model is utilized, including a net efflux rate constant kloss, and (ii) a hybrid (s/g)Patlak (hPatlak) imaging technique is introduced to enhance contrast to noise ratios (CNRs) of uptake rate Ki images. Representative set of kinetic parameter values and the XCAT phantom were employed to generate realistic 4D simulation PET data, and the proposed methods were additionally evaluated on 11 WB dynamic PET patient studies. Quantitative analysis on the simulated Ki images over 2 groups of regions-of-interest (ROIs), with low (ROI A) or high (ROI B) true kloss relative to Ki, suggested superior accuracy for gPatlak. Bias of sPatlak was found to be 16–18% and 20–40% poorer than gPatlak for ROIs A and B, respectively. By contrast, gPatlak exhibited, on average, 10% higher noise than sPatlak. Meanwhile, the bias and noise levels for hPatlak always ranged between the other two methods. In general, hPatlak was seen to outperform all methods in terms of target-to-background ratio (TBR) and CNR for all ROIs. Validation on patient datasets demonstrated clinical feasibility for all Patlak methods, while TBR and CNR evaluations confirmed our simulation findings, and suggested presence of non-negligible kloss reversibility in clinical data. As such, we recommend gPatlak for highly quantitative imaging tasks, while, for tasks emphasizing lesion detectability (e.g. TBR, CNR) over quantification, or for high levels of noise, hPatlak is instead preferred. Finally, gPatlak and hPatlak CNR was systematically higher compared to routine

  12. Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

    Science.gov (United States)

    Karakatsanis, Nicolas A.; Zhou, Yun; Lodge, Martin A.; Casey, Michael E.; Wahl, Richard L.; Zaidi, Habib; Rahmim, Arman

    2015-11-01

    We recently developed a dynamic multi-bed PET data acquisition framework to translate the quantitative benefits of Patlak voxel-wise analysis to the domain of routine clinical whole-body (WB) imaging. The standard Patlak (sPatlak) linear graphical analysis assumes irreversible PET tracer uptake, ignoring the effect of FDG dephosphorylation, which has been suggested by a number of PET studies. In this work: (i) a non-linear generalized Patlak (gPatlak) model is utilized, including a net efflux rate constant kloss, and (ii) a hybrid (s/g)Patlak (hPatlak) imaging technique is introduced to enhance contrast to noise ratios (CNRs) of uptake rate Ki images. Representative set of kinetic parameter values and the XCAT phantom were employed to generate realistic 4D simulation PET data, and the proposed methods were additionally evaluated on 11 WB dynamic PET patient studies. Quantitative analysis on the simulated Ki images over 2 groups of regions-of-interest (ROIs), with low (ROI A) or high (ROI B) true kloss relative to Ki, suggested superior accuracy for gPatlak. Bias of sPatlak was found to be 16-18% and 20-40% poorer than gPatlak for ROIs A and B, respectively. By contrast, gPatlak exhibited, on average, 10% higher noise than sPatlak. Meanwhile, the bias and noise levels for hPatlak always ranged between the other two methods. In general, hPatlak was seen to outperform all methods in terms of target-to-background ratio (TBR) and CNR for all ROIs. Validation on patient datasets demonstrated clinical feasibility for all Patlak methods, while TBR and CNR evaluations confirmed our simulation findings, and suggested presence of non-negligible kloss reversibility in clinical data. As such, we recommend gPatlak for highly quantitative imaging tasks, while, for tasks emphasizing lesion detectability (e.g. TBR, CNR) over quantification, or for high levels of noise, hPatlak is instead preferred. Finally, gPatlak and hPatlak CNR was systematically higher compared to routine SUV

  13. MORPHOLOGY OF THE SPLEEN IN ADULT ALBINO RATS AFTER WHOLE-BODY EXPOSURE TO LOW-LEVEL OF TOLUENE

    Directory of Open Access Journals (Sweden)

    Vladimir N. Voloshin

    2014-06-01

    Full Text Available Background: Spleen is a secondary lymphoid organ that is highly sensitive to different chemicals. Toluene is an aromatic hydrocarbon commonly used as an industrial solvent and can be considered as a potential immunotoxin. Aims and Objects: We aimed to investigate the organometry and histology of spleen from rats exposed to toluene. Materials and Methods: The toxicity of toluene was evaluated in male albino rats (6/group via whole-body exposure. The animals were exposed to target concentrations of 0 (air control and 133 parts per million (ppm of toluene in air for 5 hours/day, 5 days/week, for 2 month. The animals were weighted and decapitated at different time points (one, seven, sixteen, thirty one and sixty one day post-exposure. The weight, length, width and thickness of the spleen were measured. It was studied absolute and relative weight of the spleen. Histological examination of the spleen was made by light microscope. Results: Statistically significant difference between the mean of body weight from the control and experimental animals was observed seven days after last exposure to toluene. Thus, the body weight of animals exposed to toluene was 254.17 g, that was 7.18% (p = 0.048 below control data. The histological findings showed increased area of the white pulp of spleen from rats exposed to toluene had increases compared to that from the control. The numbers of siderophages were higher in the spleen from rats exposed to toluene. The relative area of germinal centre in the structure of the splenic lymph follicles of rats exposed to toluene increased. We found that in the first and second experimental groups of animals the indication was at the level 10.86% and 10.26% respectively. These are 24.11% (p = 0.002 and 26.04% (p <0.001 above control data, respectively. Inhalation exposures to toluene vapor at 133 ppm produces hyperplasia of lymphoid tissue of the rat spleen. Conclusion: Our data demonstrated that whole-body exposures to low

  14. Morphology and Ultrastructure of Brain Tissue and Fat Body from the Flesh Fly, Sarcophaga bullata Parker (Diptera: Sarcophagidae, Envenomated by the Ectoparasitic Wasp Nasonia vitripennis (Walker (Hymenoptera: Pteromalidae

    Directory of Open Access Journals (Sweden)

    David B. Rivers

    2011-01-01

    Full Text Available This study tested the hypothesis that venom from the ectoparasitic wasp Nasonia vitripennis targets brain tissue and fat body from its flesh fly host, Sarcophaga bullata. By 1 h postenvenomation, some brain neurons began to show irregularities in nuclear shape, and though they were predominately euchromatic, there was evidence of heterochromatin formation. Irregularity in the nuclear envelope became more prominent by 3 h after envenomation, as did the condensation of heterochromatin. The severity of ultrastructural changes continued to increase until at least 24 h after parasitoid attack. At this point, cellular swelling and extensive heterochromatic inclusions were evident, multivesicular bodies occurred in the cytoplasm of some cells, and the rough endoplasmic reticulum was dilated in many of the cells. Immunohistochemical staining revealed significant apoptosis in neurons located in brain tissues. By contrast, there was no evidence of any morphological or ultrastructural disturbances in fat body tissues up to 24 h after envenomation, nor did any of the cells display signs of cell death.

  15. Different {sup 18}F-FDG Uptake According to Tumor Location and Morphology of Cholangiocarcinoma and Its Clinical Implication

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Seok; Lee, Yoon Jae; Lim, Seok Tae; Sohn, Myung Hee; Lee, Seung Ok [Chonbuk National University Medical School and Hospital, Jeonju (Korea, Republic of)

    2009-08-15

    {sup 18}F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan has been found to reflect tumor aggressiveness and prognosis in various types of cancer. However, pattern of FDG uptake in biliary malignancies and its clinical significance have not been studied well. The purpose of this study was to assess the additional value of {sup 18}F-FDG PET in differential diagnosis and prognosis of cholangiocarcinoma (CC) according to the tumor location and tumor morphology. From April 2005 to May 2008, eighty two patients (M:F=55:27, age 66.2{+-}9.6 yrs) with CC underwent {sup 18}F-FDG PET. For semiquantitative analysis, the maximum standardized uptake value (SUV{sub max}) was obtained from the primary tumor. The difference of SUV{sub max} according to the tumor location and tumor growth pattern, such as scirrhous type, nodular type, polypoid type were compared. Overall sensitivity of PET scan was 81.7% in CC. SUV{sub max} on PET scan in intrahepatic CC was significantly higher compared to extrahepatic CC. In extrahepatic CC, polypoid type showed significantly higher SUV{sub max} compared to scirrhous type. {sup 18}F-FDG PET may have a significant impact on clinical decision-making and on the management of Intrahepatic cholangiocarcinoma. And it is related to the shape of the tumor and the sensitivity of detection is higher in the mass-forming type than in the scirrhous type.

  16. Vascularization of air sinuses and fat bodies in the head of the Bottlenose dolphin (Tursiops truncatus: morphological implications on physiology

    Directory of Open Access Journals (Sweden)

    Alex eCostidis

    2012-07-01

    Full Text Available AbstractCetaceans have long been considered capable of limiting diving-induced nitrogen absorption and subsequent decompression sickness through a series of behavioral, anatomical, and physiological adaptations. Recent studies however suggest that in some situations these adaptive mechanisms might be overcome, resulting in lethal and sublethal injuries. Perhaps most relevant to this discussion is the finding of intravascular gas and fat emboli in mass-stranded beaked whales. Although the source of the gas emboli has as yet to been ascertained, preliminary findings suggest nitrogen is the primary component. Since nitrogen gas embolus formation in divers is linked to nitrogen saturation, it seems premature to dismiss similar pathogenic mechanisms in breath-hold diving cetaceans. Due to the various anatomical adaptations in cetacean lungs, the pulmonary system is thought of as an unlikely site of significant nitrogen absorption. The accessory sinus system on the ventral head of odontocete cetaceans contains a sizeable volume of air that is exposed to the changing hydrostatic pressures during a dive, and is intimately associated with vasculature potentially capable of absorbing nitrogen through its walls. The source of the fat emboli has also remained elusive. Most mammalian fat deposits are considered poorly-vascularized and therefore unlikely sites of intravascular introduction of lipid, although cetacean blubber may not be as poorly vascularized as previously thought. We present new data on the vasculature of air sinuses and acoustic fat bodies in the head of bottlenose dolphins and compare it to published accounts. We show that the mandibular fat bodies and accessory sinus system are associated with extensive venous plexuses and suggest potential physiological and pathological implications.

  17. Multidetector-row computed tomography in the preoperative diagnosis of intestinal complications caused by clinically unsuspected ingested dietary foreign bodies: a case series emphasizing the use of volume rendering techniques

    Directory of Open Access Journals (Sweden)

    Augusto Cesar Vieira Teixeira

    2013-12-01

    Full Text Available Objective The present study was aimed at describing a case series where a preoperative diagnosis of intestinal complications secondary to accidentally ingested dietary foreign bodies was made by multidetector-row computed tomography (MDCT, with emphasis on complementary findings yielded by volume rendering techniques (VRT and curved multiplanar reconstructions (MPR. Materials and Methods The authors retrospectively assessed five patients with surgically confirmed intestinal complications (perforation and /or obstruction secondary to unsuspected ingested dietary foreign bodies, consecutively assisted in their institution between 2010 and 2012. Demographic, clinical, laboratory and radiological data were analyzed. VRT and curved MPR were subsequently performed. Results Preoperative diagnosis of intestinal complications was originally performed in all cases. In one case the presence of a foreign body was not initially identified as the causal factor, and the use of complementary techniques facilitated its retrospective identification. In all cases these tools allowed a better depiction of the entire foreign bodies on a single image section, contributing to the assessment of their morphology. Conclusion Although the use of complementary techniques has not had a direct impact on diagnostic performance in most cases of this series, they may provide a better depiction of foreign bodies' morphology on a single image section.

  18. Multidetector-row computed tomography in the preoperative diagnosis of intestinal complications caused by clinically unsuspected ingested dietary foreign bodies: a case series emphasizing the use of volume rendering techniques

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Augusto Cesar Vieira; Torres, Ulysses dos Santos; Oliveira, Eduardo Portela de; Gual, Fabiana; Bauab Junior, Tufik, E-mail: usantor@yahoo.com.br [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Hospital de Base. Serv. de Radiologia e Diagnostico por Imagem; Westin, Carlos Eduardo Garcia [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Hospital de Base. Cirurgia Geral; Cardoso, Luciana Vargas [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Hospital de Base. Setor de Tomografia Computadorizada

    2013-11-15

    Objective: the present study was aimed at describing a case series where a preoperative diagnosis of intestinal complications secondary to accidentally ingested dietary foreign bodies was made by multidetector-row computed tomography (MDCT), with emphasis on complementary findings yielded by volume rendering techniques (VRT) and curved multiplanar reconstructions (MPR). Materials and Methods: The authors retrospectively assessed five patients with surgically confirmed intestinal complications (perforation and/or obstruction) secondary to unsuspected ingested dietary foreign bodies, consecutively assisted in their institution between 2010 and 2012. Demographic, clinical, laboratory and radiological data were analyzed. VRT and curved MPR were subsequently performed. Results: preoperative diagnosis of intestinal complications was originally performed in all cases. In one case the presence of a foreign body was not initially identified as the causal factor, and the use of complementary techniques facilitated its retrospective identification. In all cases these tools allowed a better depiction of the entire foreign bodies on a single image section, contributing to the assessment of their morphology. Conclusion: although the use of complementary techniques has not had a direct impact on diagnostic performance in most cases of this series, they may provide a better depiction of foreign bodies' morphology on a single image section. (author)

  19. Multidetector-row computed tomography in the preoperative diagnosis of intestinal complications caused by clinically unsuspected ingested dietary foreign bodies: a case series emphasizing the use of volume rendering techniques

    International Nuclear Information System (INIS)

    Objective: the present study was aimed at describing a case series where a preoperative diagnosis of intestinal complications secondary to accidentally ingested dietary foreign bodies was made by multidetector-row computed tomography (MDCT), with emphasis on complementary findings yielded by volume rendering techniques (VRT) and curved multiplanar reconstructions (MPR). Materials and Methods: The authors retrospectively assessed five patients with surgically confirmed intestinal complications (perforation and/or obstruction) secondary to unsuspected ingested dietary foreign bodies, consecutively assisted in their institution between 2010 and 2012. Demographic, clinical, laboratory and radiological data were analyzed. VRT and curved MPR were subsequently performed. Results: preoperative diagnosis of intestinal complications was originally performed in all cases. In one case the presence of a foreign body was not initially identified as the causal factor, and the use of complementary techniques facilitated its retrospective identification. In all cases these tools allowed a better depiction of the entire foreign bodies on a single image section, contributing to the assessment of their morphology. Conclusion: although the use of complementary techniques has not had a direct impact on diagnostic performance in most cases of this series, they may provide a better depiction of foreign bodies' morphology on a single image section. (author)

  20. Clinical tolerance of total body irradiation and allogeneic bone marrow transplantation

    International Nuclear Information System (INIS)

    Total body irradiation (TBI) followed by bone marrow transplantation (BMT) is well established as a part of the conditioning regimen in high dose therapy. The objective is to report the organ toxicity investigated prospectively in patients who had conditioning regimes including fractionated TBI (FTBI) and chemotherapy. From October 2002 to December 2007 18 patients received FTBI in our institution. There were 11 males and; 7 females with median age of 20 years (range 8-50). The present study includes 11 patients with initial diagnoses; acute lymphoid leukemia (ALL), 4 - acute myeloid leukemia (AML) and 3 - chronic myeloid leukemia (GML). At the time of BMT 11 patients were in complete response, 4 in progression and 3 in chronic phase. TBI was performed on a 60Co unit in alternate prone and supine position. Three patients received nonmyeloablative regimen including 'mini' TBI of 2 Gy followed by allogeneic BMT and 15 received myeloablative regimen of 10-12 Gy FTBI. The dose rate requirement was met for TBI 5-10 cGy/min. A standardized supportive therapy was administered. During the transplantation period on day 0 and +1 of the clinical protocol the realized transplantation of the donor cells pool passed without complications in 16 of the patients and was accompanied by allergic reactions in 2 patients. Induced bone-marrow aplasia was observed in all patients during the post-transplantation period. On day +14 to +24 'entgraftment' was established in 16 patients. In 2 patients till the 35th day after the transplantation no symptoms of the grafting were observed, which imposed reinfusion of donor cells pool. Seven patients developed acute GvHD, 2 patients developed idiopathic pneumonia syndrome, 1 patient developed liver toxicity, 1 - neurological and 1 - cardiovascular toxicity. FTBI is a well tolerated therapeutic regimen in high dose therapy. The observed organ toxicity in the 18 patients in similar to that cited in reference literature. (authors)

  1. Workshop on body composition in basic and clinical research and the emerging technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wielopolski, L.

    2000-12-14

    A special one-day workshop was held to review the status, the need for, and the future role of BNL in the Body Composition Analysis Program (BCAP). Two speakers succinctly outlined the status and future new developments using gamma nuclear resonance technology as it applies to BCAP. Seven speakers from three institutions outlined the continued need for BCAP and presented new clinical applications of BCAP in theirs respective fields of expertise. Extensive increase in the use of surrogate instrumentation, e.g., DXA and BIA, in BCAP was recognized as a significant contributing factor to the growth in BCAP. The growing role of MRI in BCAP was also emphasized. In light of these developments BCAP at BNL, with its specialized In Vivo Neutron Activation (IVNA) facilities, was recognized as a unique user oriented resource that may serve the community hospitals in the area. Three regional large institutions expressed their desire to use these facilities. In addition, IVNA provides direct measure of the human compartments in vivo, thus providing a gold standard for the surrogate methodologies that are in use or to be developed. It was strongly felt that there is a need for a calibration center with a national stature for the different methodologies for in vivo measurements, a role that befits very well a national laboratory. This offers an exquisite justification for DOE to support this orphan technology and to develop BCAP at BNL to, 1, provide a user oriented regional resource, 2, provide a national reference laboratory, and 3, develop new advanced technologies for BCAP.

  2. Phase 1 Clinical Trial of Stereotactic Body Radiation Therapy Concomitant With Neoadjuvant Chemotherapy for Breast Cancer

    International Nuclear Information System (INIS)

    Purpose: Stereotactic body radiation therapy (SBRT) allows stereotactic irradiation of thoracic tumors. It may have a real impact on patients who may not otherwise qualify for breast-conserving surgery. We conducted a phase 1 trial that tested 5 dose levels of SBRT concomitant with neoadjuvant chemotherapy (NACT) before to surgery. The purpose of the current dose escalation study was to determine the maximum tolerable dose of SBRT in the treatment of breast cancer. Methods and Materials: To define toxicity, we performed dermatologic examinations that included clinical examinations by 2 separate physicians and technical evaluations using colorimetry, dermoscopy, and skin ultrasonography. Dermatologic examinations were performed before NACT, 36 and 56 days after the beginning of NACT, and before surgery. Surgery was performed 4 to 8 weeks after the last chemotherapy session. Efficacy, the primary endpoint, was determined by the pathologic complete response (pCR) rate. Results: Maximum tolerable dose was not reached. Only 1 case of dose-limiting toxicity was reported (grade 3 dermatologic toxicity), and SBRT was overall well tolerated. The pCR rate was 36%, with none being observed at the first 2 dose levels, and the highest rate being obtained at dose level 3 (25.5 Gy delivered in 3 fractions). Furthermore, the breast-conserving surgery rate was up to 92% compared with an 8% total mastectomy rate. No surgical complications were reported. Conclusions: This study demonstrates that SBRT can be safely combined with NACT. Regarding the efficacy endpoints, this trial showed promising results in terms of pCR rate (36%) and breast-conserving rate (92%). The findings provide a strong rationale for extending the study into a phase 2 trial. In view of the absence of correlation between dose and pCR, and given that the data from dose level 3 met the statistical requirements, a dose of 25.5 Gy in 3 fractions should be used for the phase 2 trial

  3. Phase 1 Clinical Trial of Stereotactic Body Radiation Therapy Concomitant With Neoadjuvant Chemotherapy for Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Bondiau, Pierre-Yves, E-mail: pierre-yves.bondiau@nice.unicancer.fr [Department of Radiotherapy, Centre Antoine Lacassagne, Nice (France); Courdi, Adel [Department of Radiotherapy, Centre Antoine Lacassagne, Nice (France); Bahadoran, Phillipe [Department of Dermatology, University Hospital of Nice, Nice (France); Chamorey, Emmanuel [Department of Radiotherapy, Centre Antoine Lacassagne, Nice (France); Queille-Roussel, Catherine [Centre de Pharmacologie Clinique Appliquée à la Dermatologie, Nice (France); Lallement, Michel; Birtwisle-Peyrottes, Isabelle; Chapellier, Claire; Pacquelet-Cheli, Sandrine; Ferrero, Jean-Marc [Department of Radiotherapy, Centre Antoine Lacassagne, Nice (France)

    2013-04-01

    Purpose: Stereotactic body radiation therapy (SBRT) allows stereotactic irradiation of thoracic tumors. It may have a real impact on patients who may not otherwise qualify for breast-conserving surgery. We conducted a phase 1 trial that tested 5 dose levels of SBRT concomitant with neoadjuvant chemotherapy (NACT) before to surgery. The purpose of the current dose escalation study was to determine the maximum tolerable dose of SBRT in the treatment of breast cancer. Methods and Materials: To define toxicity, we performed dermatologic examinations that included clinical examinations by 2 separate physicians and technical evaluations using colorimetry, dermoscopy, and skin ultrasonography. Dermatologic examinations were performed before NACT, 36 and 56 days after the beginning of NACT, and before surgery. Surgery was performed 4 to 8 weeks after the last chemotherapy session. Efficacy, the primary endpoint, was determined by the pathologic complete response (pCR) rate. Results: Maximum tolerable dose was not reached. Only 1 case of dose-limiting toxicity was reported (grade 3 dermatologic toxicity), and SBRT was overall well tolerated. The pCR rate was 36%, with none being observed at the first 2 dose levels, and the highest rate being obtained at dose level 3 (25.5 Gy delivered in 3 fractions). Furthermore, the breast-conserving surgery rate was up to 92% compared with an 8% total mastectomy rate. No surgical complications were reported. Conclusions: This study demonstrates that SBRT can be safely combined with NACT. Regarding the efficacy endpoints, this trial showed promising results in terms of pCR rate (36%) and breast-conserving rate (92%). The findings provide a strong rationale for extending the study into a phase 2 trial. In view of the absence of correlation between dose and pCR, and given that the data from dose level 3 met the statistical requirements, a dose of 25.5 Gy in 3 fractions should be used for the phase 2 trial.

  4. Build-up material requirements in clinical dosimetry during total body irradiation treatments.

    Science.gov (United States)

    Butson, Martin; Pope, Dane; Haque, Mamoon; Chen, Tom; Song, Guangli; Whitaker, May

    2016-01-01

    Total body irradiation (TBI) treatments are mainly used in a preparative regimen for hematopoietic stem cell (or bone marrow) transplantation. Our standard clinical regimen is a 12 Gy/6 fraction bi-daily technique using 6MV X-rays at a large extended source to surface distance (SSD). This work investigates and quantifies the dose build-up characteristics and thus the requirements for bolus used for in vivo dosimetry for TBI applications. Percentage dose build-up characteristics of photon beams have been investigated at large extended SSDs using ionization chambers and Gafchromic film. Open field measurements at different field sizes and with differing scatter conditions such as the introduction of standard Perspex scattering plates at different distances to the measurement point were made in an effort to determine the required bolus/build-up material required for accurate determination of applied dose. Percentage surface dose values measured for open fields at 300 cm SSD were found to range from 20% up to 65.5% for fields 5 cm × 5 cm to 40 cm × 40 cm, respectively. With the introduction of 1 cm Perspex scattering plates used in TBI treatments, the surface dose values increased up to 83-90% (93-97% at 1 mm depth), depending on the position of the Perspex scattering plate compared to the measurement point. Our work showed that at least 5 mm water equivalent bolus/scatter material should be placed over the EBT3 film for accurate dose assessment for TBI treatments. Results also show that a small but measurable decrease in measured dose occurred with 5 mm water equivalent thick bolus material of areas '3 cm(2). As such, we recommend that 3 cm × 3 cm × 5 mm bolus build-up is the smallest size that should be placed over EBT3 Gafchromic film when used for accurate in vivo dosimetry for TBI applications.

  5. Build-up material requirements in clinical dosimetry during total body irradiation treatments.

    Science.gov (United States)

    Butson, Martin; Pope, Dane; Haque, Mamoon; Chen, Tom; Song, Guangli; Whitaker, May

    2016-01-01

    Total body irradiation (TBI) treatments are mainly used in a preparative regimen for hematopoietic stem cell (or bone marrow) transplantation. Our standard clinical regimen is a 12 Gy/6 fraction bi-daily technique using 6MV X-rays at a large extended source to surface distance (SSD). This work investigates and quantifies the dose build-up characteristics and thus the requirements for bolus used for in vivo dosimetry for TBI applications. Percentage dose build-up characteristics of photon beams have been investigated at large extended SSDs using ionization chambers and Gafchromic film. Open field measurements at different field sizes and with differing scatter conditions such as the introduction of standard Perspex scattering plates at different distances to the measurement point were made in an effort to determine the required bolus/build-up material required for accurate determination of applied dose. Percentage surface dose values measured for open fields at 300 cm SSD were found to range from 20% up to 65.5% for fields 5 cm × 5 cm to 40 cm × 40 cm, respectively. With the introduction of 1 cm Perspex scattering plates used in TBI treatments, the surface dose values increased up to 83-90% (93-97% at 1 mm depth), depending on the position of the Perspex scattering plate compared to the measurement point. Our work showed that at least 5 mm water equivalent bolus/scatter material should be placed over the EBT3 film for accurate dose assessment for TBI treatments. Results also show that a small but measurable decrease in measured dose occurred with 5 mm water equivalent thick bolus material of areas '3 cm(2). As such, we recommend that 3 cm × 3 cm × 5 mm bolus build-up is the smallest size that should be placed over EBT3 Gafchromic film when used for accurate in vivo dosimetry for TBI applications. PMID:27217628

  6. Development of the ciliary body: morphological changes in the distal portion of the optic cup in the human.

    Science.gov (United States)

    Peces-Peña, M D; de la Cuadra-Blanco, C; Vicente, A; Mérida-Velasco, J R

    2013-01-01

    This study seeks to determine the main events that occur in the development of the ciliary body (CB) in the 5-14th week of development. The CB develops from the distal portion of the optic cup (OC) and the neighboring mesenchyme. During the 5th week of development, 4 zones were observed in the distal portion of the OC: in zone 1, the epithelia of the outer and inner layers of the OC came into contact. This contact coincided with the appearance of mainly apical granule pigments. This zone corresponded to the anlage of the epithelial layers of the CB. In zone 2, the cells surrounded the marginal sinus and contained scarce pigment granules and nuclei in the basal position. This zone corresponded to the anlage of the iris. Zone 3 was triangular in shape and its vertex ran towards the marginal sinus and corresponded to common cell progenitors. Zone 4 corresponded to the retinal pigment epithelium anlage and the neural retina anlage. We determined the onset of the stroma and the ciliary muscle anlage at the end of the 7th week. In the 13-14th week, we observed the anlage of the orbicularis ciliaris (pars plana of the CB) and corona ciliaris (pars plicata of the CB), in addition to the anlage of the ciliary muscle. Our study, therefore, establishes a precise timetable of the development of the CB.

  7. Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.

    Science.gov (United States)

    Wendling, Thierry; Tsamandouras, Nikolaos; Dumitras, Swati; Pigeolet, Etienne; Ogungbenro, Kayode; Aarons, Leon

    2016-01-01

    Whole-body physiologically based pharmacokinetic (PBPK) models are increasingly used in drug development for their ability to predict drug concentrations in clinically relevant tissues and to extrapolate across species, experimental conditions and sub-populations. A whole-body PBPK model can be fitted to clinical data using a Bayesian population approach. However, the analysis might be time consuming and numerically unstable if prior information on the model parameters is too vague given the complexity of the system. We suggest an approach where (i) a whole-body PBPK model is formally reduced using a Bayesian proper lumping method to retain the mechanistic interpretation of the system and account for parameter uncertainty, (ii) the simplified model is fitted to clinical data using Markov Chain Monte Carlo techniques and (iii) the optimised reduced PBPK model is used for extrapolation. A previously developed 16-compartment whole-body PBPK model for mavoglurant was reduced to 7 compartments while preserving plasma concentration-time profiles (median and variance) and giving emphasis to the brain (target site) and the liver (elimination site). The reduced model was numerically more stable than the whole-body model for the Bayesian analysis of mavoglurant pharmacokinetic data in healthy adult volunteers. Finally, the reduced yet mechanistic model could easily be scaled from adults to children and predict mavoglurant pharmacokinetics in children aged from 3 to 11 years with similar performance compared with the whole-body model. This study is a first example of the practicality of formal reduction of complex mechanistic models for Bayesian inference in drug development.

  8. Associations of prepartum body condition score with occurrence of clinical endometritis and resumption of postpartum ovarian activity in dairy cattle.

    Science.gov (United States)

    Kadivar, Ali; Ahmadi, Mohammad Rahim; Vatankhah, Mahmood

    2014-01-01

    This study was performed to investigate the effect of periparturient body condition score on the occurrence of clinical endometritis and postpartum resumption of ovarian activity in dairy cows. Eighty-seven lactating Holstein cows, fed with a total mixed ration diet, were included into the study. Body condition scoring (using a 5-point scale with quarter-point divisions) was performed by the same investigator using the visual technique every 2 weeks, from 2 weeks before until 6 weeks after calving. Palpation of the reproductive tract and ultrasonographic assessment of ovaries for detection of corpus luteum using a rectal linear probe was also performed at 2, 4, and 6 weeks after calving. Cows with clinical endometritis had significantly lower body condition score (BCS) than normal cows at all weeks pre- and postcalving, and cows that did not ovulate until 45 days after calving had a significantly lower BCS pre- and postpartum. Cows that did not ovulate until 45 days after calving also lost more BCS from 2 weeks before to 4 weeks after calving. Besides, first ovulation after calving take occurred later in cows with clinical endometritis compared to normal cows (P BCS is a risk factor for postpartum endometritis and delayed cyclicity in dairy cows. BCS loss from dry-off to early lactation and occurrence of clinical endometritis can significantly affect postpartum ovarian activity.

  9. The Aberrant Right Subclavian Artery (Arteria Lusoria): The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    OpenAIRE

    Michał Polguj; Łukasz Chrzanowski; Kasprzak, Jarosław D.; Ludomir Stefańczyk; Mirosław Topol; Agata Majos

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinical...

  10. Clinical Observation on the Effect of Earlobe-Bleeding plus Body Acupuncture in 85 Cases of Common Acne

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Objective: To observe the clinical effect of earlobe-bleeding plus body acupuncture for common acne. Methods: The earlobe-bleeding plus local and body acupuncture based on syndrome differentiation was adopted for 85 cases of common acne. Results: Of the 85 cases treated, 61 were cured, 12 markedly effective, 9 improved, and 3 failed. The total effective rate was 96.47%. Conclusions: The therapy can treat both the Biao-symptom and Ben-root of common acne, short in course and effective in result.

  11. CLINICAL OBSERVATION ON 36 CASES OF SCAPULOHUMERAL PERIARTHRITIS TREATED BY ABDOMINAL ACUPUNCTURE AND BODY-ACUPUNCTURE

    Institute of Scientific and Technical Information of China (English)

    睢明河

    2001-01-01

    Objective: To compare the therapeutic effect of abdominal acupuncture plus body acupuncture and simple body acupuncture in treatment of scapulohumeral periarthritis. Methods: 68 cases of scapulohumeral periarthritis patients were randomly divided into abdominal acupuncture plus body acupuncture (AABA) group (n= 36) and simple body acupuncture (BA) group (n=32). In AABA group, abdominal acupuncture points used were Zhongwan(CV 12), Shangqu (KI 17) (on the healthy side) and Huaroumen-sanjiao (on the affected side); and body acupoints employed were Jianyu (LI 15), Jianliao(TE 14), Binao (LI 14), Quchi (LI 11), Waiguan (TE 5) and Hegu (LI 4) on the affected side. In BA group, the body acupoints used were the same to those mentioned above. The acupuncture needles were retained for 20 min. Acupuncture treatment was given once daily, with 10 sessions being a therapeutic course and the interval between two courses being one week. 2 courses of treatment were conducted altogether. Results: Following 2 courses of treatment, in AABA and BA groups, 6 (16.7%) and 1 (3.1%) cases were cured, 19 (52.8%) and 12 (37.5%) had remarkable improvement, 11 (30.6%) and 17 (53.1%) had improvement, 0 and 2 (6.25%) had no effect respectively. There was a significant difference between two groups in the therapeutic effect (P<0.05) .Conclusion: The therapeutic effect of abdominal acupuncture plus body acupuncture is superior to that of simple body acupuncture in treatment of scapulohumeral periarthritis.

  12. Clinical and morphologic evaluation of Er:YAG laser action at the front of cervical dentinal hypersensitivity

    International Nuclear Information System (INIS)

    This work was achieved in vivo and in vitro to evaluate the efficiency of Er:YAG laser in the cervical dentinal hypersensitivity treatment (HSDC). The Clinical study was achieved in patients with HSDC. The treatment was realized in five sessions: the first for selection, the second for exams (clinic and X-Ray) and trying to remove the etiologic factors that could cause the HSDC. The third and fourth sessions were subjected to the radiation with that protocol: 60 mJ energy ,2 Hz frequency, 6 mm out of focus, under air cooling, 20 seconds each application which the same was repeated four times with one minute breaks, which scanning movements and without using anaesthetics. The fifth was evaluation. The patients were evaluated and registered in a subject scale of pain 0 to 3, in the beginning and end of each session of irradiation, and one month after the last session. The results showed that for the irradiated group occurs significant differences in the beginning of each session and between. For the control group did not occur significant differences in the beginning and after each session, but did show a difference between the sessions. As the control group as the irradiated group, had reduction of sensibility between the session. For the morphologic study nine teeth were selected, 7 molars and 2 pre-molars from operative dentistry discipline. Half of the surface was irradiated with Er:YAG laser, the same protocol used in vivo, and the other half was used as a control without receiving any laser irradiation. Subsequently, specimens were prepared for SEM examinations. The results showed that laser treated surfaces showed a reduction of dentine tubular diameter with partial or total closure of the dentine tubules. For the control group, it was observed bigger amounts smear layer and open dentine tubular. The results obtained indicated that the Er:YAG laser can contribute to the HSDC treatment. (author)

  13. Healthy Minds in Healthy Bodies: Adolescent Clinics and Middle Schools in Collaboration.

    Science.gov (United States)

    Reyes, Augustina H.; Fowler, Michelle

    1999-01-01

    Explores the development of a collaboration between a clinic and an urban middle school in a high-poverty, language minority community in Texas. Considers the need for an adolescent clinic and issues of community support, funding, clinic objectives, and problems. (JPB)

  14. Clinical And Morphological Androgenic Status Characteristics At Children Suffering From Hypospadias And Its Influence On Results Of Surgical Correction

    Directory of Open Access Journals (Sweden)

    F.K. Napolnikov

    2009-09-01

    Full Text Available The goal of this article is to estimate the androgenic status and analyze its influence on the surgical treatment of hypospadias. From 2000 till 2008 there were 209 children under treatment, whose age varied from 8 months till 15 years old (average age — 4,5+ 1,5. 49 patients were subjected to clinical, humoral and morphological study. Preoperational preparation was carried out by testosterone medications. The comparison group consisted of 10 boys with cicatricial phimosis. The patients with the medium and back forms of hypospadias suffered from the androgenic deficit characterized by proximal level of meatus ectopia, diminution of penis length and prostate volume, decrease of blood vessels in deep layers of penis skin. The testosterone pre-operational medication of patients makes possible to improve the results of surgical correction due to blood supply of plastic material. On the basis of recieved data logistically regressive model has been worked out and the prognosis of results has been estimated

  15. Clinical Value of Whole-body Magnetic Resonance Diffusion Weighted Imaging on Detection of Malignant Metastases

    Institute of Scientific and Technical Information of China (English)

    Cheng Li; Zhen-sheng Liu; Xian-mao Du; Ling He; Jian Chen; Wei Wang; Fei Sun; Fang Du; Zhi-gang Luo; Zhen-long Xue; Yi Zhao; Chang-wu Zhou

    2009-01-01

    To evaluate the value of whole-body diffusion weighted imaging (WB-DWI) on detection of malignant metastasis.Methods Forty-six patients with malignant tumors underwent WB-DWI examinations between April 2007 and August 2007 in our hospital. Before WB-DWI examination, the primary cancers of all the patients were confirmed by pathology, and the TNM-stage was assessed with conventional magnetic resonance imaging (MRI) or computed tomography (CT). WB-DWl was performed using short TI inversion recovery echo-planar imaging (STIR-EPI) sequence. Abnormal high signal intensities on WB-DWI were considered as metastases. The results of WB-DWI were compared with other imaging modalities. For the assessment of the diagnostic capability of WB-DWl, WB-DWI were compared with CT for demonstrating mediastinal lymph node metastases and lung metastases, and with conventional MRI for demonstrating metastases in other locations.Results WB-DWI demonstrated 143 focuses, 14 of which were diagnosed to he benign lesions in routine imaging. The number of bone metastases depicted on WB-DWI and routine imaging was 85 and 86; lymph node metastases was 17 and 18; liver metastases was 14 and 14; lung metastases was 4 and 8; and brain metastases was 6 and 8, respectively. WB-DWI failed to detect 12 metastatic lesions including 3 osteoplastic bone metastases, 4 lung metastases, 3 mediastinal lymph node metastases, and 2 brain metastases. Four metastatic lesions including 2 deltopectoral lymph nodes and 2 rib metastases were detected with WB-DWI alone, all of which evolved greatly during clinical follow-up for more than 6 months. WB-DWI had higher detection rates for metastatic lesions in liver, bone, and lymph nodes than those in lung and brain (X2=30, P<0.001).Conclusions WB-DWI could detect most of metastatic lesions that were diagnosed with conventional MRI and CT. The limitations of WB-DWI might be had high false-positive rate and low efficiency in detecting mediastinal lymph node, brain, and

  16. Genetic risk score does not correlate with body mass index of Latina women in a clinical trial.

    Science.gov (United States)

    Coenen, Kimberly R; Karp, Sharon M; Gesell, Sabina B; Dietrich, Mary S; Morgan, Thomas M; Barkin, Shari L

    2011-10-01

    Obesity disproportionately affects Latina women. Common genetic variants are convincingly associated with body mass index (BMI) and may be used to create genetic risk scores (GRS) for obesity that could define genetically influenced forms of obesity and alter response to clinical trial interventions. The objective of this study was (1) to identify the frequency and effect size of common obesity genetic variants in Latina women; (2) to determine the clinical utility of a GRS for obesity with Latina women participating in a community-based clinical trial. DNA from 85 Latina women was genotyped for eight genetic variants previously associated with BMI in Caucasians, but not yet assessed in Latina populations. The main outcome measure was the correlation of GRS (sum of eight risk alleles) with BMI, waist circumference, and percent body fat. A majority (83%) of participants had a BMI ≥25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians. Association of each locus with BMI was lower in Latinas compared to Caucasians with no significant correlations with BMI. We conclude that an eight locus GRS has no clinical utility for explaining obesity or predicting response to intervention in Latina women participating in a clinical trial.

  17. Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma

    OpenAIRE

    Andrew Hendifar; Arsen Osipov; Jasleen Khanuja; Nicholas Nissen; Jason Naziri; Wensha Yang; Quanlin Li; Richard Tuli

    2016-01-01

    Obesity is a known risk factor for PDA and recent reports suggest obesity has a negative impact on clinical outcomes in patients with PDA. Pretreatment body mass index (BMI) and serum albumin (SA) have been shown to be associated with worse overall survival in patients with advanced and metastatic PDA. However, minimal data exists on the impact of BMI and SA on perioperative and long-term clinical outcomes in patients with early-stage resected PDA. Herein, we report on the impact of these var...

  18. Illness, body and relationship: Giovanni Jervis and the field of clinical psychology.

    Science.gov (United States)

    Williams, Riccardo

    2012-01-01

    Unlike most of his contemporaries, Jervis felt it was necessary to give new answers to last century's clinical psychology crisis. He managed to show the relevance that psychological knowledge coming from other sectors (such as philosophy, evolutionary biology, cybernetics, ethology and, nowadays, neuroscience) could have for clinical psychology. He realized that the clinical world was at risk of loosing its cultural models of reference and threatened to break up with the scientific tradition with which it had not been able to establish a profitable dialogue. Jervis' views on mental functioning allowed him to delimit the field of action of clinical psychology. The focus on pathology and existential distress suggested that correct clinical evaluation and diagnosis are at the core of the activity of clinical psychologists. The tension between relational expectations, self-deceptive aspects of identity and the bodily sources of mental life show the dynamic field on which clinical psychology can deploy its transformative action.

  19. Visual Representation of Body Shape in African-American and European American Women: Clinical Considerations

    Science.gov (United States)

    Capers, Patrice L.; Kinsey, Amber W.; Miskell, Edrika L.; Affuso, Olivia

    2016-01-01

    BACKGROUND Body mass index (BMI) has been used widely among clinicians to assess obesity in their patients due to its ease and availability. However, BMI has some diagnostic limitations and other measures related to health risks; in particular, body shape may be of greater relevance to health outcomes. OBJECTIVE The objective of this study was to illustrate the importance of body shape assessments above and beyond BMI and its relationship to health risk among a sample of African-American and European American women. METHODS African-American and European American women aged 19–78 years (n = 552) in Birmingham, Alabama, were recruited and stratified by menopausal status (ie, pre- or postmenopausal). Pictorial body shapes were derived from digital photographs, while body fat distribution defined by android–gynoid ratio (AGR) and body composition were obtained from dual-energy X-ray absorptiometry. RESULTS Images of BMI and age-matched women illustrate variability in fat distribution. Among both menopausal status groups, more than 50% of women had a pear body shape (AGR < 1). An apple body shape was associated with higher odds of having diabetes (unadjusted odds ratio [OR]: 4.1, 95% confidence interval [CI]: 1.9–9.3), hypertension (unadjusted OR: 3.1, 95% CI: 2.0–4.7), and high cholesterol (unadjusted OR: 3.0, 95% CI: 1.8–5.1). CONCLUSION Use of visual cues alongside traditional methods of weight status assessment may help to facilitate weight management conversations between physicians and female patients. However, next steps should include the validation of visual assessments of body shape in women for use by physicians. PMID:27478392

  20. Under-representation of women on governing bodies: women general practitioners on Clinical Commissioning Groups in England.

    Science.gov (United States)

    Segar, Julia

    2015-10-01

    Recently formed Clinical Commissioning Groups in the English National Health Service have important responsibility for commissioning local health and care services. Women are under-represented on the governing bodies of these significant primary care based organizations despite the fact that they constitute almost half of the general practitioner workforce in England. This essay examines some of the reasons for this under-representation including the predominance of women in the salaried and part-time sector of general practice and gendered management styles within the National Health Service. It is argued that the under-representation of women on Clinical Commissioning Group governing bodies matters in terms of social justice, representation of the broader community and role models. PMID:25589088

  1. Non-uniformity of Clinical Head, Head and Neck, and Body Coils in Magnetic Resonance Imaging (MRI

    Directory of Open Access Journals (Sweden)

    Mahmood Nazarpoor

    2014-11-01

    Full Text Available Introduction Signal intensity uniformity in a magnetic resonance (MR image indicates how well the MR imaging (MRI system represents an object. One of the major sources of image non-uniformity in high-field MRI scanners is inhomogeneity of radio-frequency coil. The aim of this study was to investigate non-uniformity in head, head and neck, and body coils and compare the obtained results to determine the best clinical coil for future clinical application. Materials and Methods A phantom was designed to investigate the non-uniformity of coils. All evaluations were carried out using a 1.5 T clinical MRI scanner. T1-weighted inversion recovery sequence (linear phase encoding and turbo fast low angle shot (TurboFLASH images were used to find non-uniformity in the clinical coils. For testing the uniformity of coils, signal intensity profiles in parts of the coronal image of phantom were measured over X and Y axes. Results The results showed that body coil was the most uniform coil of all; in addition, the head and neck coil was more uniform than the head coil. The results also indicated that signal-to-noise ratio (SNR of the head and neck coil was higher than the head and body coils. Moreover, SNR of the head coil was higher than that of the body coil. Conclusion In order to accurately find or apply an image signal intensity for measuring organ blood flow or perfusion, coil non-uniformity corrections are required.

  2. Representativeness and optimal use of body mass index (BMI) in the UK Clinical Practice Research Datalink (CPRD)

    OpenAIRE

    Bhaskaran, K; Forbes, H. J.; Douglas, I.; Leon, D. A.; Smeeth, L

    2013-01-01

    Objectives: To assess the completeness and representativeness of body mass index (BMI) data in the Clinical Practice Research Datalink (CPRD), and determine an optimal strategy for their use. Design: Descriptive study. Setting: Electronic healthcare records from primary care. Participants: A million patient random sample from the UK CPRD primary care database, aged ≥16 years. Primary and secondary outcome measures: BMI completeness in CPRD was evaluated by age, sex and calendar period. CPR...

  3. Is whole-body trauma MDCT justified in patients in good clinical condition but with dangerous trauma mechanism?

    International Nuclear Information System (INIS)

    Background: To assess whether whole body MDCT is justified in patients in good clinical condition yet with dangerous trauma mechanism. Material/Methods:The study included 81 patients who were examined between January and July 2008 with whole-body trauma CT protocol. Inclusion into the study was based on a dangerous trauma mechanism and the possibility of an unbiased calculation of the weighted revised trauma score (RTSw). All examinations were performed with 16 row MDCT scanner located in emergency department. The cut off of the RTSw over 6.0 was used to separate the patients in good clinical condition. The CT examinations and medical records of patients were reviewed to assess the number of significant injuries, the need for emergency surgery and other types of medical treatment, the number of negative CT examinations, the number of patients admitted to hospital, and mortality. Results: 28 life-threatening injuries were found in 21 of 61 patients with RTS over 6.0 (34.4%). Only two of those patients required emergency surgery (laparotomy). CT studies were negative for traumatic injuries in 22 patients from this group (36.0%). Conclusions: Whole-body MDCT may detect injuries in patients in good clinical condition, with some of them demanding medical treatment. Still, further studies are required to balance the advantages of MDCT and potentially harmful effects of radiation dose, especially better triage systems and low-dose protocols are needed

  4. Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial

    OpenAIRE

    Greulich, Timm; Nell, Christoph; Koepke, Janine; Fechtel, Juliane; Franke, Maja; Schmeck, Bernd; Haid, Daniel; Apelt, Sandra; Filipovic, Silke; Kenn, Klaus; Janciauskiene, Sabina; Vogelmeier, Claus; Koczulla, Andreas Rembert

    2014-01-01

    Background Patients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiotherapy in exacerbated hospitalised COPD patients would be safe and would improve exercise capacity and quality of life. Methods 49 hospitalised exacerbated COPD patients were randomized (1:1) to undergo physiotherapy alone or physiotherapy with the addition of whole body vibratio...

  5. Yoga and Mindfulness: Clinical Aspects of an Ancient Mind/Body Practice

    Science.gov (United States)

    Salmon, Paul; Lush, Elizabeth; Jablonski, Megan; Sephton, Sandra E.

    2009-01-01

    The use of Yoga and other complementary healthcare interventions for both clinical and non-clinical populations has increased substantially in recent years. In this context, we describe the implementation of Hatha Yoga in the Mindfulness-Based Stress Reduction (MBSR) program of Kabat-Zinn and colleagues. This is embedded in a more general…

  6. Automatic recognition of disorders, findings, pharmaceuticals and body structures from clinical text: an annotation and machine learning study.

    Science.gov (United States)

    Skeppstedt, Maria; Kvist, Maria; Nilsson, Gunnar H; Dalianis, Hercules

    2014-06-01

    Automatic recognition of clinical entities in the narrative text of health records is useful for constructing applications for documentation of patient care, as well as for secondary usage in the form of medical knowledge extraction. There are a number of named entity recognition studies on English clinical text, but less work has been carried out on clinical text in other languages. This study was performed on Swedish health records, and focused on four entities that are highly relevant for constructing a patient overview and for medical hypothesis generation, namely the entities: Disorder, Finding, Pharmaceutical Drug and Body Structure. The study had two aims: to explore how well named entity recognition methods previously applied to English clinical text perform on similar texts written in Swedish; and to evaluate whether it is meaningful to divide the more general category Medical Problem, which has been used in a number of previous studies, into the two more granular entities, Disorder and Finding. Clinical notes from a Swedish internal medicine emergency unit were annotated for the four selected entity categories, and the inter-annotator agreement between two pairs of annotators was measured, resulting in an average F-score of 0.79 for Disorder, 0.66 for Finding, 0.90 for Pharmaceutical Drug and 0.80 for Body Structure. A subset of the developed corpus was thereafter used for finding suitable features for training a conditional random fields model. Finally, a new model was trained on this subset, using the best features and settings, and its ability to generalise to held-out data was evaluated. This final model obtained an F-score of 0.81 for Disorder, 0.69 for Finding, 0.88 for Pharmaceutical Drug, 0.85 for Body Structure and 0.78 for the combined category Disorder+Finding. The obtained results, which are in line with or slightly lower than those for similar studies on English clinical text, many of them conducted using a larger training data set, show that

  7. Foreign Body Granulomas Induced by Intramuscular Leuprorelin Acetate Injection for Prostate Cancer: Clinical Mimics of Soft Tissue Sarcoma

    Directory of Open Access Journals (Sweden)

    Khin Thway

    2015-01-01

    Full Text Available We describe two cases of florid, foreign body granulomatous reaction occurring in the upper arms of males in their eighth decade, who were undergoing treatment with depot injection of leuprorelin acetate for prostatic carcinoma. These patients presented with rapidly enlarging extremity soft tissue masses and were referred to a tertiary sarcoma center with clinical suspicion of a primary soft tissue neoplasm. The occurrence of injection site granulomas secondary to leuprorelin acetate administration is rarely known outside the urological and dermatological communities, and their recognition is important due to the spectrum of clinical differential diagnoses and potential for diagnostic confusion with metastatic prostatic cancer and primary sarcoma and in order to avoid unnecessary stress and clinical intervention for patients.

  8. Aesthetic skin branding: a novel form of body art with adverse clinical sequela.

    Science.gov (United States)

    Karamanoukian, Raffy; Ukatu, Chidi; Lee, Edward; Hyman, Josh; Sundine, Michael; Kobayashi, Mark; Evans, Gregory R D

    2006-01-01

    Branding is a form of body art wherein third-degree burns are inflicted on the skin to produce permanent scars. This method of scarification is a common practice among many indigenous cultures and has become exceedingly common in western societies. As with other forms of body art, branding is not a manifestation of a psychiatric disorder but, rather, a method of self-expression. The process can be performed through the use of electrocautery, laser, chemicals, freezing, and hot metal. Complications arising from the procedure include acute infection, transmission of blood-borne pathogens, allergic reactions, and sequelae arising from third-degree burns. In addition, skin branding has been shown to be associated with substance abuse and high-risk behaviors among adolescents. The purpose of this article is to present the following case report and review to familiarize clinicians with this dangerous method of body art.

  9. Management of rectal foreign bodies: Description of a new technique and clinical practice guidelines

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A number of techniques have been described to remove rectal foreign bodies. In this report, a novel endoscopic technique using a pneumatic dilatation balloon normally used in achalasia patients is presented. In addition, a systematic review of the literature was performed for non-operative methods to remove foreign bodies from the rectum. These results are summarised, presented as a practical at-a- glance overview and a flow chart is offered to guide the clinician in treatment decisions. The design of the flow chart was based on the aims to treat the patient preferably on an outpatient basis with minimally invasive techniques and if possible under conscious sedation rather than general anaesthesia.

  10. Accumulation of Mutant Neuroserpin Precedes Development of Clinical Symptoms in Familial Encephalopathy with Neuroserpin Inclusion Bodies

    OpenAIRE

    Galliciotti, G; Glatzel, M; Kinter, J.; Kozlov, S V; Cinelli, P.; Rülicke, T; Sonderegger, P.

    2007-01-01

    Intracellular protein deposition due to aggregation caused by conformational alteration is the hallmark of a number of neurodegenerative disorders, including Parkinson's disease, tauopathies, Huntington's disease, and familial encephalopathy with neuroserpin inclusion bodies. The latter is an autosomal dominant disorder caused by point mutations in neuroserpin resulting in its destabilization. Mutant neuroserpin polymerizes and forms intracellular aggregates that eventually lead to neurodegen...

  11. Clinical Application of a Behavioral Model for the Treatment of Body Dysmorphic Disorder

    Science.gov (United States)

    Rabinowitz, Dena; Neziroglu, Fugen; Roberts, Marty

    2007-01-01

    Body dysmorphic disorder (BDD) is characterized by an obsessive concern over a perceived flaw in bodily appearance. If a minor flaw does exist, the patient displays unwarranted distress. This preoccupation typically leads to compulsive behaviors, such as mirror checking or mirror avoiding, camouflaging, and seeking reassurance from others…

  12. Prevalence of Body Dysmorphic Disorder Symptoms and Associated Clinical Features among Australian University Students

    Science.gov (United States)

    Bartsch, Dianna

    2007-01-01

    The current study addressed the frequency of body dysmorphic disorder (BDD) symptoms among university students and investigated the predictors of dysmorphic concern. Six hundred and nineteen Australian university students completed measures assessing BDD, dysmorphic concern, self-esteem, depression, life satisfaction, self-oriented and socially…

  13. CLINICAL ANALYSIS ON SCALP-PLUS BODY-ACUPUNCTURE FOR TREATMENT OF SENILE URINARY INCONTINENCE

    Institute of Scientific and Technical Information of China (English)

    LU Zeqiang

    2002-01-01

    To observe the therapeutic effect of scalp-plus body-acupuncture for treatment of senile urinary incontinence. Methods: A total of 71 urinary incontinence outpatients were randomly divided into treatment group (n = 37)and control group (n= 34). In treatment group, scalp-plus body-acupuncture was conducted once daily, with 10 days being a therapeutic course. Scalp acupoints used were Epangxian Ⅲ (MS 4) and Dingzhongxian (MS 5), while body acupoints used were Guanyuan (CV 4), Shuidao (ST 28), Qichong (ST 30), Yanglingquan (GB 34), Sanyinjiao (SP 6), etc.. The treatment was given once daily, with 10 days being a therapeutic course. In control group, patients were ordered to take Centrofenoxine, ATP, Vitamin E and B12, with ten days being a therapeutic course. Results: After 3 courses of treatment, in treatment group, of the 37 patients, 26 (70.3%) were cured, 6 (16.0%) had marked improvement, 3 (8.1%) had improvement and 2 (5.4%) failed; in control group, of the 34 patients, 14 (41.1% ) were cured, 9 (26.5%) had remarkable improvement, 3 (8.8%) had improvement and 8 (23.5%) failed, showing that the therapeutic effect of the treatment group was significantly superior to that of control group ( P< 0.05). Conclusion:The therapeutic effect of scalp plus body acupuncture is fairly effective in treatment of senile urinary incontinence.

  14. CLINICAL STUDY ON CLIMACTERIC SYNDROME TREATED WITH AURICULAR PLUS BODY ACUPUNCTURE

    Institute of Scientific and Technical Information of China (English)

    徐天舒

    2003-01-01

    Aim: To search for the best therapeutic method for climacteric syndrome. Methods: A total of 190 cases of climacteric syndrome participants were randomly divided into auricular plus body acupuncture group (treatment group, n = 96) and simple body acupuncture group (control group, n = 94). Serum sexual hormone (FSH, LH and E2) and blood lipid (TC, LDL-C, HDL-C and TG) levels were detected before and after treatment. Results: After 30sessions of treatment, the total effective rates of treatment and control groups were 82.29% and 76.02% respectively, with the former being significantly higher than the later ( P < 0.01 ). In comparison with pre-treatment of each group, serum follicle-stimulating hormone (FSH) and luterotropic hormone (LH) levels lowered significantly; serum estradiol (E2) increased remarkably ( P < 0.05 - 0.01 ); serum high-density l ipoprotein-cholesterol (HDL-C) of two groups raised significantly ( P< 0.05- 0.01 ), and Iow-density lipoprotein (LDL)-C of treatment group decreased evidently (P< 0.05). In addition, the improvement of complaints of hot flushes, sweating, paresthesia, insomnia and emotional irritability in treatment group is significantly better than that of control group. Conclusion: Auricular acupuncture combined with body acupuncture has a better therapeutic effect than that of simple body acupuncture in the treatment of climacteric syndrome.

  15. Clinical approach to discoloration in body hair in a Rottweiler dog

    OpenAIRE

    Or M.E.; Kayar A.; Parkan Ç.; Gönül R.; Morkoç T.; Dodurka H.T.

    2005-01-01

    Micanfin (Biocan-M®, Bioveta) is a new veterinary drug used successfully in the treatment and prophylaxis of dermetomycosis in dogs and cats. In this study, leukotrichia was determined after administration of Micanfin and the objective was to determine the diagnosis and treatment protocol of the case. The case was a male Rottweiler dog, aged four, weighing 35 kg, presented with alopecia at a special veterinary clinic. A routine clinical examination, skin scraping, and antibiogram-mycologic ex...

  16. [The Sudeck-Leriche syndrome as a disturbance in distant regions of the body, clinical picture, and histology (author's transl)].

    Science.gov (United States)

    Kirsch, K

    1978-01-01

    On the whole, every Sudeck-Leriche syndrome represents a serious complication. The causal noxae are various in nature. In a large case material during a period of observation extending over 26 years a Sudeck-Leriche syndrome was observed as a disturbance in distant regions of the body only in rare cases, for example after herpes zoster, apoplexy, and confusion of the cervical part of the medulla, with cervical and lumbal root irritations, etc. Histological findings in the case of Sudeck-Leriche syndrome are very rarely presented in literature. Histological investigations by the author carried out on muscle tissue in the case of Sudeck-Leriche syndrome yielded remarkable findings with a transition from functional to morphologically irreversible alterations. These alterations were present both in vessels and muscle fibers. PMID:77594

  17. Clinical Observation on Treatment of 63 Cases of Enuresis by Scalp Acupuncture,Body Acupuncture plus Moxibustion with BOX

    Institute of Scientific and Technical Information of China (English)

    LU Ze-qiang; KUAI Le

    2007-01-01

    To observe the clinical therapeutic effect of scalp acupuncture,body acupuncture plus moxibustion with box in treating enuresis.Methods:Ninety-three patients were divided into treatment group of 63 cases and control group of 30 cases.Scalp acupuncture,body acupuncture plus moxibustion with box were used in treatment group.Routine western medicine therapy was used in control group.Results and Conclusion:The cured rate was 69.8% and the total effective rate was 95.3% in the treatment group and 33.3% and 76.7% in the control group.The therapeutic effect in treatment group was superior to that in control group(P<0.05).

  18. Postmortem whole-body magnetic resonance imaging as an adjunct to autopsy: preliminary clinical experience.

    Science.gov (United States)

    Patriquin, L; Kassarjian, A; Barish, M; Casserley, L; O'Brien, M; Andry, C; Eustace, S

    2001-02-01

    The purpose of this study was to evaluate whole-body magnetic resonance imaging (MRI) of cadavers as an adjunct to autopsy. Eight consecutive patients underwent both whole-body MRI and autopsy [either conventional (six), limited (one), or percutaneous (one)] within 24 hours of death. Comparison was made of major and minor abnormalities and predicted cause of death recorded by independent readers at both MRI and autopsy. Major discrepancies between the recorded primary cause of death at imaging and autopsy occurred in five (5) patients. These included a myocardial infarction found at autopsy alone, bowel infarction and portal venous gas found at MRI alone, and aortic dissection and occipital infarct found at MRI alone in a patient on whom only limited autopsy was performed. Postmortem MRI may represent a useful adjunct to autopsy, particularly in patients in whom autopsy is limited due to patient/family consent, inoculation risks, and ethnic doctrines.

  19. Clinical features of muscle dysmorphia among males with body dysmorphic disorder.

    Science.gov (United States)

    Pope, Courtney G; Pope, Harrison G; Menard, William; Fay, Christina; Olivardia, Roberto; Phillips, Katharine A

    2005-12-01

    Muscle dysmorphia - a pathological preoccupation with muscularity - appears to be a form of body dysmorphic disorder (BDD) with a focus on muscularity. However, little is known about muscle dysmorphia in men with BDD, and no study has compared men with BDD who do and do not report muscle dysmorphia. To explore this issue, we reviewed the histories of 63 men with BDD; we compared those rated as having a history of muscle dysmorphia with those who had BDD but not muscle dysmorphia in several domains. The 14 men with muscle dysmorphia resembled the 49 comparison men in demographic features, BDD severity, delusionality, and number of non-muscle-related body parts of concern. However, those with muscle dysmorphia were more likely to have attempted suicide, had poorer quality of life, and had a higher frequency of any substance use disorder and anabolic steroid abuse. Thus, muscle dysmorphia was associated with greater psychopathology. PMID:17075613

  20. Distribution and pharmacokinetics of methamphetamine in the human body: clinical implications

    Energy Technology Data Exchange (ETDEWEB)

    Volkow, N.D.; Fowler, J.; Volkow, N.D.; Fowler, J.S.; Wang, G.-J.; Shumay, E.; Telang, F.; Thanos, P.; Alexoff, D.

    2010-12-01

    Methamphetamine is one of the most toxic of the drugs of abuse, which may reflect its distribution and accumulation in the body. However no studies have measured methamphetamine's organ distribution in the human body. Positron Emission Tomography (PET) was used in conjunction with [{sup 11}C]d-methamphetamine to measure its whole-body distribution and bioavailability as assessed by peak uptake (% Dose/cc), rate of clearance (time to reach 50% peak-clearance) and accumulation (area under the curve) in healthy participants (9 Caucasians and 10 African Americans). Methamphetamine distributed through most organs. Highest uptake (whole organ) occurred in lungs (22% Dose; weight {approx}1246 g), liver (23%; weight {approx}1677 g) and intermediate in brain (10%; weight {approx}1600 g). Kidneys also showed high uptake (per/cc basis) (7%; weight 305 g). Methamphetamine's clearance was fastest in heart and lungs (7-16 minutes), slowest in brain, liver and stomach (>75 minutes), and intermediate in kidneys, spleen and pancreas (22-50 minutes). Lung accumulation of [{sup 11}C]d-methamphetamine was 30% higher for African Americans than Caucasians (p < 0.05) but did not differ in other organs. The high accumulation of methamphetamine, a potent stimulant drug, in most body organs is likely to contribute to the medical complications associated with methamphetamine abuse. In particular, we speculate that methamphetamine's high pulmonary uptake could render this organ vulnerable to infections (tuberculosis) and pathology (pulmonary hypertension). Our preliminary findings of a higher lung accumulation of methamphetamine in African Americans than Caucasians merits further investigation and questions whether it could contribute to the infrequent use of methamphetamine among African Americans.

  1. Distribution and pharmacokinetics of methamphetamine in the human body: clinical implications

    International Nuclear Information System (INIS)

    Methamphetamine is one of the most toxic of the drugs of abuse, which may reflect its distribution and accumulation in the body. However no studies have measured methamphetamine's organ distribution in the human body. Positron Emission Tomography (PET) was used in conjunction with (11C)d-methamphetamine to measure its whole-body distribution and bioavailability as assessed by peak uptake (% Dose/cc), rate of clearance (time to reach 50% peak-clearance) and accumulation (area under the curve) in healthy participants (9 Caucasians and 10 African Americans). Methamphetamine distributed through most organs. Highest uptake (whole organ) occurred in lungs (22% Dose; weight ∼1246 g), liver (23%; weight ∼1677 g) and intermediate in brain (10%; weight ∼1600 g). Kidneys also showed high uptake (per/cc basis) (7%; weight 305 g). Methamphetamine's clearance was fastest in heart and lungs (7-16 minutes), slowest in brain, liver and stomach (>75 minutes), and intermediate in kidneys, spleen and pancreas (22-50 minutes). Lung accumulation of (11C)d-methamphetamine was 30% higher for African Americans than Caucasians (p < 0.05) but did not differ in other organs. The high accumulation of methamphetamine, a potent stimulant drug, in most body organs is likely to contribute to the medical complications associated with methamphetamine abuse. In particular, we speculate that methamphetamine's high pulmonary uptake could render this organ vulnerable to infections (tuberculosis) and pathology (pulmonary hypertension). Our preliminary findings of a higher lung accumulation of methamphetamine in African Americans than Caucasians merits further investigation and questions whether it could contribute to the infrequent use of methamphetamine among African Americans.

  2. Clinical evaluation of nares-vocal cord distance and its correlation with various external body parameters

    Directory of Open Access Journals (Sweden)

    Bhuwan Sareen

    2015-01-01

    Full Text Available Background and Aims: The optimal visualisation of vocal cords during fibreoptic intubation may be utilised for the nares-vocal cord distance (NVD estimation. The present study was conducted to measure NVD and to correlate with various external body parameters. Methods: This study was conducted on 50 males and 50 females. We measured NVD and analysed its relationship with height, nares to tragus of ear distance (NED, nares to angle of mandible distance (NMD, sternal length (SL, thyro-mental distance (TMD, sterno-mental distance (SMD and arm span (AS. Results: The mean NVD of the males was 18.5 ± 1.5 cm, and that of the females was 15.9 ± 1.1 cm. The relationship between the NVD and body height (males P = 0.001, r = 0.463, females P = 0.000, r = 0.555, SL (males P = 0.000, r = 0.463, females P < 0.000, r = 0.801 or AS (males P = 0.000, r = 0.561, females P = 0.000, r = 0.499 showed a significant correlation but NED, NMD, TMD, SMD did not. After combining male and female groups, (n = 100, the correlation of NVD with external body parameters is as follows SL (r = 0.887, height (r = 0.791, AS (r = 0.769, weight (r = 0.531, SMD (r = 0.466, NED (r = 0.459, NMD (r = 0.391, TMD (r = 0.379. Conclusion: The relationship of NVD to external body parameters had strong correlation in all parameters in the combined group; whereas when gender was taken into consideration NVD correlated significantly only with SL, height and AS.

  3. The relationship between alexithymia, shame, trauma, and body image disorders: investigation over a large clinical sample

    Directory of Open Access Journals (Sweden)

    Franzoni E

    2013-02-01

    Full Text Available Emilio Franzoni,1 Stefano Gualandi,1 Vincenzo Caretti,2 Adriano Schimmenti,3 Elena Di Pietro,1 Gaetano Pellegrini,1 Giuseppe Craparo,3 Arianna Franchi,1 Alberto Verrotti,4 Alessandro Pellicciari11Child Neuropsychiatry Unit, University of Bologna, Italy; 2Department of Psychology, University of Palermo, Italy; 3Faculty of Human and Social Sciences, Kore University of Enna, Enna, Italy; 4Department of Pediatrics, University of Chieti, ItalyBackground: The connections between eating disorders (EDs and alexithymia have not been fully clarified. This study aims to define alexithymia's connections with shame, trauma, dissociation, and body image disorders.Methods: We administered the Dissociative Experience Scale-II, Trauma Symptom Inventory, Experience of Shame Scale, Toronto Alexithymia Scale-20, and Body Uneasiness Test questionnaires to 143 ED subjects. Extensive statistical analyses were performed.Results: The subjects showed higher scores on alexithymia, shame, dissociation, and traumatic feelings scales than the nonclinical population. These aspects are linked with each other in a statistically significant way. Partial correlations highlighted that feelings of shame are correlated to body dissatisfaction, irrespective of trauma or depressed mood. Multiple regression analysis demonstrates that shame (anorexic patients and perceived traumatic conditions (bulimic and ED not otherwise specified are associated with adverse image disorders.Conclusion: Shame seems to hold a central role in the perception of an adverse self-image. Alexithymia may be interpreted as being a consequence of previous unelaborated traumatic experiences and feelings of shame, and it could therefore be conceptualized as a maladaptive–reactive construct.Keywords: eating disorders, trauma, alexithymia, shame, body image

  4. Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Min [Univ. of Ulsan, Seoul (Korea, Republic of). Dept. of Radiation Oncology] (and others)

    2006-12-15

    The aim of this study was to evaluate the treatment outcomes of stereotactic body radiation therapy for treating primary or metastatic thoracic tumors using a stereotactic body frame. Between January 1998 and February 2004, 101 lesions from 91 patients with thoracic tumors were prospectively reviewed. A dose of 10-12 Gy per fraction was given three to four times over consecutive days to a total dose of 30-48 Gy (median 40 Gy). The overall response rate was 82%, with 20 (22%) complete responses and 55 (60%) partial responses. The one- and two-year local progression free survival rates were 90% and 81%, respectively. The patients who received 48 Gy showed a better local tumor control than those who received less than 48 Gy (Fisher exact test; p=0.004). No pulmonary complications greater than a RTOG toxicity criteria grade 2 were observed. The experience of stereotactic body frame based radiation therapy appears to be a safe and promising treatment modality for the local management of primary or metastatic lung tumors. The optimal total dose, fractionation schedule and treatment volume need to be determined after a further follow-up of these results.

  5. Development and clinical application of a length-adjustable water phantom for total body irradiation.

    Science.gov (United States)

    Chen, Zhi-Wei; Yao, Sheng-Yu; Zhang, Tie-Ning; Zhu, Zhen-Hua; Hu, Zhe-Kai; Lu, Xun

    2012-08-01

    A new type of water phantom which would be specialised for the absorbed dose measurement in total body irradiation (TBI) treatment is developed. Ten millimetres of thick Plexiglas plates were arranged to form a square cube with 300 mm of edge length. An appropriate sleeve-type piston was installed on the side wall, and a tabular Plexiglas piston was positioned inside the sleeve. By pushing and pulling the piston, the length of the self-made water phantom could be varied to meet the required patients' physical sizes. To compare the international standard water phantom with the length-adjustable and the Plexiglas phantoms, absorbed dose for 6-MV X ray was measured by an ionisation chamber at different depths in three kinds of phantoms. In 70 cases with TBI, midplane doses were metered using the length-adjustable and the Plexiglas phantoms for simulating human dimensions, and dose validation was synchronously carried out. There were no significant statistical differences, p > 0.05, through statistical processing of data from the international standard water phantom and the self-designed one. There were significant statistical differences, p body width. Obviously, the difference had a positive correlation with the body width. The results proved that the new length-adjustable water phantom is more accurate for simulating human dimensions than Plexiglas phantom.

  6. Illusory changes in body size modulate body satisfaction in a way that is related to non-clinical eating disorder psychopathology.

    OpenAIRE

    Catherine Preston; Henrik Ehrsson, H.

    2014-01-01

    Historically, body size overestimation has been linked to abnormal levels of body dissatisfaction found in eating disorders. However, recently this relationship has been called into question. Indeed, despite a link between how we perceive and how we feel about our body seeming intuitive, until now lack of an experimental method to manipulate body size has meant that a causal link, even in healthy participants, has remained elusive. Recent developments in body perception research demonstrate t...

  7. Review of the Interaction Between Body Composition and Clinical Outcomes in Metastatic Renal Cell Cancer Treated With Targeted Therapies

    OpenAIRE

    Steven M Yip; Heng, Daniel Y. C.; Tang, Patricia A.

    2016-01-01

    Treatment of metastatic renal cell cancer (mRCC) currently focuses on inhibition of the vascular endothelial growth factor pathway and the mammalian target of rapamycin (mTOR) pathway. Obesity confers a higher risk of RCC. However, the influence of obesity on clinical outcomes in mRCC in the era of targeted therapy is less clear. This review focuses on the impact of body composition on targeted therapy outcomes in mRCC. The International Metastatic Renal Cell Carcinoma Database Consortium dat...

  8. Widespread atypical vascular lesions of the skin after whole-body electron beam therapy: expanding the clinical spectrum.

    Science.gov (United States)

    Sinclair, Werner

    2013-02-01

    Atypical vascular lesion of the skin is an uncommon usually benign condition, thus far reported almost exclusively from mammary skin after radiotherapy for carcinoma of the breast. Some clinical and histological overlap exists with early angiosarcoma, which can also occur on irradiated skin. The lesions are divided into vascular and lymphatic types, the first representing a higher risk for development of angiosarcoma and the latter being more common. This article reports a rare case of widespread, progressive, vascular-type atypical vascular lesion after repeated whole-body electron beam irradiation administered as treatment for mycosis fungoides.

  9. Clinical correlations with lewy body pathology in LRRK2-related Parkinson disease

    NARCIS (Netherlands)

    L.V. Kalia (Lorraine V.); A.E. Lang (Anthony E.); L.-N. Hazrati (Lili-Naz); S. Fujioka (Shinsuke); Z.K. Wszolek (Zbigniew); D. Dickson (Dennis); O.A. Ross (Owen); V.M. Deerlin (Vivianna); J.Q. Trojanowski (John); H.I. Hurtig (Howard); R.N. Alcalay (Roy N.); K.S. Marder (Karen S.); L.N. Clark (Lorraine N.); C. Gaig; E. Tolosa; J. Ruiz-Martínez (Javier); J.F. Marti-Masso (Jose F.); I. Ferrer (Isidro); A. López De Munain (Adolfo); S.M. Goldman (Samuel M.); B. Schüle (Birgitt); J.W. Langston (J. William); J.O. Aasly (Jan); M.T. Giordana; V. Bonifati (Vincenzo); A. Puschmann (Andreas); M. Canesi (Margherita); G. Pezzoli (Gianni); A. Maues De Paula (Andre); K. Hasegawa (Kazuko); C. Duyckaerts (Charles); A. Brice (Alexis); A.J. Stoessl (A. Jon); C. Marras (Connie)

    2015-01-01

    textabstractIMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD

  10. Prevalence of body dysmorphic disorder in patients referred to Razi hospital cosmetic clinic with complaints of cosmetic disorders

    Directory of Open Access Journals (Sweden)

    Amirhooshang Ehsani

    2013-06-01

    Full Text Available Background: Body dysmorphic disorder (BDD is characterized by a preoccupation with an imagined defect in ones appearance or an exaggeration of a slight physical anomaly. Any part of the appearance may be the focuse of BDD patients. Thus preoccupation with appearance leads to significant damages of social and job functioning. The aim of this study is to determine the prevalence of BDD in patients referred to cosmetic clinic of Razi hospital.Methods: Patients visiting cosmetic clinic of Razi hospital were selected if they agreed to participate in the study. They were evaluated by Yale brown obsessive compulsive scale modified for body dysmorphic disorder (YBOCS-BDD as well as questionnaires containing demographic characteristics of patients including gender, educational status, marital status, history of reference to psychiatrist or psychologist, other medication, history of cosmetic surgery and rate of satisfaction of cosmetic surgery. YBOCS-BDD questionnaires then processed by educated specialist to determine BDD score of patie-nts. Demographic questionnaires, also analysed to evaluate epidemiologic properties of patients visiting cosmetic clinic of Razi hospital.Results: The prevalence of BDD in current sample was 33.3%. 70.7% of BDD patients were female while 29.3% were male. The commonest age range was 21-50 years (82.8%. 65.5% were educated to level of diploma or lower, while 34.5% had academic degrees. 51.7% were married. 20.7% had history of reference to psychiatrist or psycholo-gist. 17/2% had history of cosmetic surgery with satisfaction ranging from unsatisfied (20% to relative satisfaction (80%. None were fully satisfied.Conclusion: BDD had high prevalence in patients visiting cosmetic clinic of Razi skin hospital. This high rate of prevalence show the necessity of diagnosis of BDD in skin patients and it is critical for them to refer to psychiatrists or psychologists.

  11. Comorbidity between obsessive-compulsive disorder and body dysmorphic disorder: prevalence, explanatory theories, and clinical characterization

    OpenAIRE

    Frías Á; Palma C; Farriols N; González L

    2015-01-01

    Álvaro Frías,1,2 Carol Palma,1,2 Núria Farriols,1,2 Laura González2 1FPCEE Blanquerna, Universitat Ramon Llull, Barcelona, 2Adult Outpatient Mental Health Center, Hospital de Mataró – CSdM, Mataró, Spain Background: With the advent of the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, body dysmorphic disorder (BDD) has been subsumed into the obsessive-compulsive disorders and related disorde...

  12. Clinical features of muscle dysmorphia among males with body dysmorphic disorder

    OpenAIRE

    Pope, Courtney G.; Pope, Harrison G.; Menard, William; Fay, Christina; Olivardia, Roberto; Phillips, Katharine A.

    2005-01-01

    Muscle dysmorphia – a pathological preoccupation with muscularity – appears to be a form of body dysmorphic disorder (BDD) with a focus on muscularity. However, little is known about muscle dysmorphia in men with BDD, and no study has compared men with BDD who do and do not report muscle dysmorphia. To explore this issue, we reviewed the histories of 63 men with BDD; we compared those rated as having a history of muscle dysmorphia with those who had BDD but not muscle dysmorphia in several do...

  13. Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience

    International Nuclear Information System (INIS)

    To implement total body irradiation (TBI) using volumetric modulated arc therapy (VMAT). We applied the Varian RapidArc™ software to calculate and optimize the dose distribution. Emphasis was placed on applying a homogenous dose to the PTV and on reducing the dose to the lungs. From July 2013 to July 2014 seven patients with leukaemia were planned and treated with a VMAT-based TBI-technique with photon energy of 6 MV. The overall planning target volume (PTV), comprising the whole body, had to be split into 8 segments with a subsequent multi-isocentric planning. In a first step a dose optimization of each single segment was performed. In a second step all these elements were calculated in one overall dose-plan, considering particular constraints and weighting factors, to achieve the final total body dose distribution. The quality assurance comprised the verification of the irradiation plans via ArcCheck™ (Sun Nuclear), followed by in vivo dosimetry via dosimeters (MOSFETs) on the patient. The time requirements for treatment planning were high: contouring took 5–6 h, optimization and dose calculation 25–30 h and quality assurance 6–8 h. The couch-time per fraction was 2 h on day one, decreasing to around 1.5 h for the following fractions, including patient information, time for arc positioning, patient positioning verification, mounting of the MOSFETs and irradiation. The mean lung dose was decreased to at least 80 % of the planned total body dose and in the central parts to 50 %. In two cases we additionally pursued a dose reduction of 30 to 50 % in a pre-irradiated brain and in renal insufficiency. All high dose areas were outside the lungs and other OARs. The planned dose was in line with the measured dose via MOSFETs: in the axilla the mean difference between calculated and measured dose was 3.6 % (range 1.1–6.8 %), and for the wrist/hip-inguinal region it was 4.3 % (range 1.1–8.1 %). TBI with VMAT provides the benefit of satisfactory dose

  14. Solenoid coil for mouse-model MRI with a clinical 3-Tesla imager: body imaging

    OpenAIRE

    Hidalgo, S. S.; D. Jirak; S.E. Solis; Rodríguez, A.O.

    2009-01-01

    A solenoid coil was built for magnetic resonance imaging of the mice. A coil prototype composed of 5 turns, with a length of 4 cm and 2.5 cm radius was developed to acquire (whole) body mouse magnetic resonance images at 130 MHz and an insertable gradient coil set. Coil performance was measured using the Q factor for both the loaded and unloaded cases were 161.67 and 178.03, respectively. These Q factors compare very well with those values reported in the literature. The images were acquired ...

  15. Effect of Supragingival Irrigation with Aerosolized 0.5% Hydrogen Peroxide on Clinical Periodontal Parameters, Markers of Systemic Inflammation, and Morphology of Gingival Tissues in Patients with Periodontitis

    Science.gov (United States)

    Žekonis, Gediminas; Žekonis, Jonas; Gleiznys, Alvydas; Noreikienė, Viktorija; Balnytė, Ingrida; Šadzevičienė, Renata; Narbutaitė, Julija

    2016-01-01

    Background Various studies have shown that non-surgical periodontal treatment is correlated with reduction in clinical parameters and plasma levels of inflammatory markers. The aim of this study was to evaluate the effect of long-term weekly supragingival irrigations with aerosolized 0.5% hydrogen peroxide as maintenance therapy followed by non-surgical periodontal treatment on clinical parameters, plasma levels of inflammatory markers, and morphological changes in gingival tissues of patients with periodontitis. Material/Methods In total, 43 patients with chronic periodontitis were randomly allocated to long-term maintenance therapy. The patients’ periodontal status was assessed using clinical parameters of approximal plaque index, modified gingival index, bleeding index, pocket probing depth, and plasma levels of inflammatory markers (high-sensitivity C-reactive protein and white blood cell count) at baseline and after 1, 2, and 3 years. The morphological status of gingival tissues (immediately after supragingival irrigation) was assessed microscopically. Results Complete data were obtained on 34 patients. A highly statistically significant and consistent reduction was observed in all long-term clinical parameters and plasma levels of inflammatory markers. Morphological data showed abundant spherical bubbles in gingival tissues. Conclusions 1. The present study showed that non-surgical periodontal treatment with long-term weekly supragingival irrigations with aerosolized 0.5% hydrogen peroxide improved clinical periodontal status and plasma levels of inflammatory markers and may be a promising method in periodontology. 2. We found that supragingival irrigation with aerosolized 0.5% hydrogen peroxide created large numbers of spherical bubbles in gingival tissues. PMID:27743448

  16. Cozy landscapes in a time of subtleties: Resonance of dance in a body treatment clinic in mental health care

    Directory of Open Access Journals (Sweden)

    Ingrid Bergma da Silva Oliveira

    2013-12-01

    Full Text Available The quest to build cozy landscapes in times of subtleties in mental health care is based on an ethical and poetic choice to build a clinic. This study deals with research aimed at the cartography of a body treatment clinic in mental health that has used various practices in this perspective of coziness and subtleties within a Psychosocial Attendance Center (PSAC - type II in Belém, Para state, Brazil. In the methodological path we have traveled in these practices, we would like to highlight the work with Sacred Circle Dances (SCD in the experience of a Body Work Group involving 14 service users between 2010 and 2012. We resorted to participant observation and records in field notebook to find highlights in the intensity of meetings, especially regarding the experiments with dance. The results showed that, in Sacred Circle Dances, service users battled for their spaces, shared their stories, gave in and demanded, pulling away from any stereotype of passivity, and possible lack of motivation, or victimization In conclusion, SCD subscribe the emancipation of dancers of “expected” acting to the dance, in a territory that comprises dance together and do with others, which enriches experience and sustains differences. SCD in the daily routine of PSACs reaffirm that those centers are not a place of mental illness, but of mental health, where the relief is life and the disorder is only a part of existence. SCD are configured as a potential place of exchange.

  17. Assessment of sarcopenia and changes in body composition after neoadjuvant chemotherapy and associations with clinical outcomes in oesophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yip, Connie [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); National Cancer Centre, Department of Radiation Oncology, Singapore (Singapore); Imaging 2, Level 1, Lambeth Wing, St Thomas' Hospital, London (United Kingdom); Goh, Vicky [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust, London (United Kingdom); Davies, Andrew; Gossage, James; Mason, Robert [Guy' s and St Thomas' NHS Foundation Trust, Department of Upper Gastrointestinal and General Surgery, London (United Kingdom); Mitchell-Hay, Rosalind; Griffin, Nyree [Department of Radiology, Guy' s and St Thomas' NHS Foundation Trust, London (United Kingdom); Hynes, Orla [Department of Dietetics, Guy' s and St Thomas' NHS Foundation Trust, London (United Kingdom); Maisey, Nick; Ross, Paul; Gaya, Andrew [Department of Oncology, Guy' s and St Thomas' NHS Foundation Trust, London (United Kingdom); Landau, David B. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Department of Oncology, Guy' s and St Thomas' NHS Foundation Trust, London (United Kingdom); Cook, Gary J. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom)

    2014-05-15

    Sarcopenia and changes in body composition following neoadjuvant chemotherapy (NAC) may affect clinical outcome. We assessed the associations between CT body composition changes following NAC and outcomes in oesophageal cancer. A total of 35 patients who received NAC followed by oesophagectomy, and underwent CT assessment pre- and post-NAC were included. Fat mass (FM), fat-free mass (FFM), subcutaneous fat to muscle ratio (FMR) and visceral to subcutaneous adipose tissue ratio (VA/SA) were derived from CT. Changes in FM, FFM, FMR, VA/SA and sarcopenia were correlated to chemotherapy dose reductions, postoperative complications, length of hospital stay (LOS), circumferential resection margin (CRM), pathological chemotherapy response, disease-free survival (DFS) and overall survival (OS). Nine (26 %) patients were sarcopenic before NAC and this increased to 15 (43 %) after NAC. Average weight loss was 3.7 % ± 6.4 (SD) in comparison to FM index (-1.2 ± 4.2), FFM index (-4.6 ± 6.8), FMR (-1.2 ± 24.3) and VA/SA (-62.3 ± 12.7). Changes in FM index (p = 0.022), FMR (p = 0.028), VA/SA (p = 0.024) and weight (p = 0.007) were significant univariable factors for CRM status. There was no significant association between changes in body composition and survival. Loss of FM, differential loss of VA/SA and skeletal muscle were associated with risk of CRM positivity. (orig.)

  18. Correlation of glucose metabolism in brain cells and brain morphological changes with clinical typing in children with cerebral palsy

    Institute of Scientific and Technical Information of China (English)

    Qiongxiang Zhai; Huixian Qiao; Jiqing Liu

    2006-01-01

    BACKGROUND:It is widely known that fluorino-18-fluorodeoxyglucose positron emission tomography(18F-FDG PET)is commonly used to evaluate and diagnose epilepsy;however,whether it is beneficial to understand functional metabolism of bra in cells so as to reflect injured site and degree of brain cells or not should be studied further.OBJECTIVE:To evaluate the correlation between glucose metabolism and clinical typling as well as the conelation between active function of brain cells and degree of brain injury among children with cerbral palsy with 18F-FDG PET and MRI and compare the results of them.DESIGN:Case analysis.SETTING:Department of Pediatrics,People's Hospital of Guangdong Province.PARTICIPANTS:A total of 31 children with cerebral palsy were selected from Out-patient Clinic and In-patient Department of People's Hospital of Guangdong Province from July 2001 to August 2004.Based on clinical criteria of cerebral palsy,patients were classified into spasm(n=10),gradual movement(n=4),mixed type(n =13)and ataxia(n=4).There were 18 boys and 13 girls aged from 10 months to 4 years.All of them were met the diagnostic criteria of cerebral palsy and all parents of them were told the facts.Exclusion cdteria:Patients who had cerebral palsy caused by genetic metabolism disease were excluded.METHODS:①All children accepted MRI examination after hospitalization with Philips Acs NT 15T superconductling magnetic resonance scanner.②All children were fasted for 4 hours.And then,PET image of brain was collected based on T+EID type.If obvious hypermetabolism or hypometabolism region successively occurred on two layers, the image was regarded as abnormality. ③Different correlations of various abnormal greups of MRI and vadous types of cerebral palsy with PET image were compared and analyzed with Erusal-Willas rank sum test.MAIN OUTCOME MEASURES:①Results of 18F-FDG PET;②Results of MRI examination;③Correlation of variously abnormal groups of MRI and various types of cerebral

  19. Associations between body mass index, weight control concerns and behaviors, and eating disorder symptoms among non-clinical Chinese adolescents

    Directory of Open Access Journals (Sweden)

    Hu Xiaoqi

    2010-06-01

    Full Text Available Abstract Background Previous research with adolescents has shown associations of body weight, weight control concerns and behaviors with eating disorder symptoms, but it is unclear whether these associations are direct or whether a mediating effect exists. This study was conducted to investigate the prevalence of overweight and obesity, weight control concerns and behaviors, and eating disorder symptoms and to examine the mediating function of weight control concerns and behaviors on the relationship between body mass index (BMI and eating disorder symptoms among non-clinical adolescents in China. Methods A cross-sectional survey among 2019 adolescent girls and 1525 adolescent boys in the 7th, 8th, 10th and 11th grades from seven cities in China was conducted. Information on weight control concerns and behaviors, and eating disorder symptoms (Eating Disorder Inventory-3 were collected from the adolescents using a self-administrated questionnaire. Results Weight control concerns and behaviors, and eating disorder symptoms were prevalent among the study population. A high proportion of adolescents scored at or above the threshold on the eating disorder inventory (EDI subscale such as bulimia, interoceptive deficits, perfectionism, and maturity fears, which indicated eating disorder symptoms. High BMI was significantly associated with high score of drive for thinness, body dissatisfaction, bulimia, low self-esteem, interceptive deficits and maturity fears, so do perceived body weight status. Almost all weight control concerns and behaviors we investigated were significantly associated with high EDI subscale scores. When weight control concerns were added to the model, as shown in the model, the association between BMI and tendency of drive to thinness and bulimia was attenuated but still kept significant. The association between BMI and body dissatisfaction were no further significant. The association of BMI and drive for thinness, body

  20. Clinical significance of the morphological distribution of the vastus medialis insertion for selection of subvastus approach in total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    Huang Baohua; Hou Zhiqi; Chen Yuanming; Qin Jian

    2015-01-01

    Objective To survey and analyze the relationship between the vastus medialis( VM) insertion on the patella and the body projection so as to provide an innovative path to the preoperative evaluation in selecting the subvastus approach in total knee arthroplasty( TKA) . Methods Body-surface projection of the VM patellar insertion was surveyed and the anatomic shape was observed in 20 sides of lower limb specimens. The body-surface projection of the VM patellar insertion was also measured on 80 sides of lower limbs in healthy adults. The distribution results of the VM patellar insertion in the three conditions were compared. Results The ratio of the vastus medialis body length to the patellar length was 40% to 60% in 55. 0% specimens (11 cases). The ratios were (47. 8 ± 15. 1)%, (48. 7 ± 15. 4)% and (46. 7 ± 14. 8)% in the cadaver-surface-observation group, autopsy group and in vivo surface group, respectively. There was no statistical difference (P>0. 05). Conclusions There was no statistical difference in the ratios of the VM patellar insertion length to the patellar length calculated by the observed body-surface-projection values and by the measurements after anatomy. Preoperative evaluation of the body-surface-projection of the VM patellar insertion may play a referential role in the selection of the TKA approach.

  1. Clinical application of glass dosimeter for in vivo dose measurements of total body irradiation treatment technique

    Energy Technology Data Exchange (ETDEWEB)

    Rah, Jeong-Eun; Hwang, Ui-Jung; Jeong, Hojin; Lee, Sang-Yeob; Lee, Doo-Hyun; Shin, Dong Ho; Yoon, Myonggeun; Lee, Se Byeong [Proton Therapy Center, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 410-769 (Korea, Republic of); Lee, Rena [Department of Radiation Oncology, Mokdong Hospital, Ewha Womans University College of Medicine (Korea, Republic of); Park, Sung Yong, E-mail: cool_park@ncc.re.k [Proton Therapy Center, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 410-769 (Korea, Republic of)

    2011-01-15

    The commercially available glass dosimeter (model GD-301) was investigated for its dosimetric characteristics, in order to evaluate its use for in vivo dosimetry. We specifically assessed overall precision of dosimetric dose data in patients who received treatment with the total body irradiation (TBI). Uniformity obtained in this study was within 1.2% (1 SD). The dose-response was linear in the range of 0.5-10 Gy with R of 0.999. Dose rate, SSD, field size, angular and energy dependence were found to be within 3.0%. In vivo skin dosimetry for TBI was performed for 3 patients. For all patients, the glass dosimeter was exposed and measured dose recorded for one fraction in addition to conventional used TLD and MOSFET. Overall uncertainty of the glass dosimeter for in vivo dose measurement was estimated at 2.4% (68.3% confidence level). The measured doses of the glass dosimeter were well within {+-}5.0% of the prescription dose at all sites expect mediastinum of one patient, for which it is within {+-}5.7%. Agreement of measured doses between glass dosimeter and TLD, MOSFET was within {+-}6.3% and {+-}6.6%, respectively. Results show that the glass dosimeter can be used as an accurate and reproducible dosimeter for TBI treatment skin dose measurements. The glass dosimeter is a practical alternative to TLD or MOSFET as an in vivo dosimeter.

  2. Kwabenya shadow shield whole body counter for clinical diagnosis and medical research

    International Nuclear Information System (INIS)

    The construction of a shadow shield whole body counter, using 5.08 cm thick interlocking lead bricks and a 12.7 cm x 10.16 cm NaI(Tl) detector, is described. The final shielding reduced the 100% background, (corresponding to the unshielded detector) to 4.2% in the energy range 1 - 2 MeV. The sensitivity of the counter for the isotopes Iron 59, Cobalt 59, Calcium 47, Sodium 22 and Iodine 131 was 3.5 x 10-3, 4.9 x 10-3, 4.1 x 10-3 and 2.8 x 10-3 microcuries, respectively, using a water phantom for 30-minute scans. The sensitivity for Iron 59 in human subjects was found to be 3.3 x 10-3 microcuries. The redistribution effect on count rates was also studied using point sources placed in wooden phantoms. The maximum longitudinal variation in sensitivity was found to be less than 2%, while the lateral variation had a maximum of approximately 14%. Periodic scanning of three normal Ghanaians for up to a maximum of seven hours after oral administration of Iron 59 showed a maximum variation of activity of 4% approximately, even where two of the subjects had had a meal of rice and chicken one hour after the isotope was administered

  3. Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

    Directory of Open Access Journals (Sweden)

    Osawa Y

    2014-11-01

    Full Text Available Yusuke Osawa,1,2,* Koichiro Azuma,3,* Shogo Tabata,3 Fuminori Katsukawa,2 Hiroyuki Ishida,2 Yuko Oguma,2 Toshihide Kawai,4 Hiroshi Itoh,4 Shigeo Okuda,5 Hideo Matsumoto3 1Japan Society for the Promotion of Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan; 2Sports Medicine Research Center, Keio University, Kanagawa, Japan; 3Institute for Integrated Sports Medicine, School of Medicine, Keio University, Tokyo, Japan; 4Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan; 5Department of Radiology, School of Medicine, Keio University, Tokyo, Japan *Yusuke Osawa and Koichiro Azuma are co-first authors of this article Abstract: It is unclear whether combined leg and arm high-intensity interval training (HIIT improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC and arm-cranking (AC ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7 and the other LC- and AC-HIIT (n=5 twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%±38%; P<0.05 and the LC–AC groups (11%±9%; P<0.05. The CSA of the quadriceps femoris muscles also increased from baseline in both the LC (11%±4%; P<0.05 and the LC–AC groups (5%±5%; P<0.05. In contrast, increases were observed in the CSA of

  4. Reconstruction of Extended and Morphologically Varied Alveolar Ridge Defects with the Titanium Mesh Technique: Clinical and Dental Implants Outcomes.

    Science.gov (United States)

    Lizio, Giuseppe; Mazzone, Noemi; Corinaldesi, Giuseppe; Marchetti, Claudio

    2016-01-01

    A sample of 24 patients with varied morphologic defects were treated with 34 titanium meshes and particulate bone and rehabilitated at least 8 to 9 months thereafter with the placement of 88 implants. Of the 34 meshes, 4 had to be removed before implant placement (11.76% total failure) and 20 were exposed due to soft tissue dehiscence (58.82% of complications): 4 (11.77%) prematurely (within 4 to 6 weeks) and 16 (47.05%) delayed (after 4 to 6 weeks), with no compromise in implant placement. None of the 88 implants was lost (100% implant survival), and 15 demonstrated increased bone loss, yielding a cumulative implant success rate of 82.9%. This technique appears useful in treating extended and morphologically varied alveolar defects. PMID:27560673

  5. Selected clinical chemistry analytes correlate with the pathogenesis of inclusion body hepatitis experimentally induced by fowl aviadenoviruses.

    Science.gov (United States)

    Matos, Miguel; Grafl, Beatrice; Liebhart, Dieter; Schwendenwein, Ilse; Hess, Michael

    2016-10-01

    In the present study, clinical chemistry was applied to assess the pathogenesis and progression of experimentally induced inclusion body hepatitis (IBH). For this, five fowl aviadenovirus (FAdV) strains from recent IBH field outbreaks were used to orally inoculate different groups of day-old specific pathogen-free chickens, which were weighed, sampled and examined during necropsy by sequential killing. Mortalities of 50% and 30% were recorded in two groups between 6 and 9 days post-infection (dpi), along with a decreased weight of 23% and 20%, respectively, compared to the control group. Macroscopical changes were seen in the liver and kidney between 6 and 10 dpi, with no lesions being observed in the other organs. Histological lesions were observed in the liver and pancreas during the same period. Plasma was collected from killed birds of each group at each time point and the following clinical chemistry analytes were investigated: aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH), bile acids, total protein, albumin, uric acid and lipase. Plasma protein profile, AST and GLDH, together with bile acids values paralleled the macroscopical and histopathological lesions in the liver, while plasma lipase activity levels coincided with lesions observed in pancreas. In agreement with the histology and clinical chemistry, viral load in the target organs, liver and pancreas, was highest at 7 dpi. Thus, clinical chemistry was found to be a valuable tool in evaluating and monitoring the progression of IBH in experimentally infected birds, providing a deeper knowledge of the underlying pathophysiological mechanisms of a FAdV infection in chickens.

  6. Experimental autoimmune encephalomyelitis (EAE): lesion visualization on a 3 tesla Clinical whole-body system after intraperitoneal contrast injection

    Energy Technology Data Exchange (ETDEWEB)

    Heckl, S.; Naegele, T.; Klose, U. [Dept. of Neuroradiology, Medical School, Univ. of Tuebingen (Germany); Herrmann, M.; Gaertner, S.; Weissert, R. [Dept. of Neurology, Medical School, Univ. of Tuebingen (Germany); Schick, F. [Dept. of Radiology, Medical School, Univ. of Tuebingen (Germany); Kueker, W. [Dept. of Neuroradiology, Medical School, Univ. of Tuebingen (Germany); Dept. of Neuroradiology, Radcliffe Infirmary, Oxford, England (United Kingdom)

    2004-11-01

    Purpose: To investigate the intravital visibility of CNS lesions in rats with experimental autoimmune encephalomyelitis (EAE), the animal correlate of multiple sclerosis, using a 3-Tesla (T) wholebody MR system. Materials and Methods: Three healthy Dark Agouti (DA) rats and 16 DA rats with clinical signs of EAE were examined on a 3T whole body-system using a normal wrist coil. In total, 25 examinations were preformed using T2- and T1-weighted images in transverse and sagittal orientation with a slice thickness of 2 mm or 1 mm (voxel size up to 0.2 x 0.2 x 1 mm). Sedation was achieved by intraperitoneal injection of ketamine and xylazine. In addition, T1-weighted images were obtained after the instillation of 1.0 ml of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) (0.5 mmol/ml) into the peritoneal cavity. Results: T2- and T1-weighted images of the brain and spinal cord with high spatial and contrast resolution could be obtained in all animals. The anatomical details of the olfactory bulb glomeruli, cerebellum foliae, ventricles and corpus callosum were clearly visible. The EAE lesions presented as hyperintense area in T2-weighted images and could be demonstrated in all clinically affected animals by MRI and histologically verified. In total, the 16 affected rats had 28 cerebral and 2 spinal cord lesions (range 1 to 4, median 2). Contrast enhancement was noted in 12 animals and ranked as severe in ten and moderate in two cases. No adverse effects were noted due to sedation or intraperitoneal contrast injection. Conclusions: The intravital demonstration of cerebral and spinal cord EAE lesions in rats is possible on a 3T whole-body MR scanner using a normal wrist coil. Intraperitoneal injection of ketamine/xylazine and contrast agent is an easy, safe and effective procedure in rats. (orig.)

  7. Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma.

    Science.gov (United States)

    Hendifar, Andrew; Osipov, Arsen; Khanuja, Jasleen; Nissen, Nicholas; Naziri, Jason; Yang, Wensha; Li, Quanlin; Tuli, Richard

    2016-01-01

    Obesity is a known risk factor for PDA and recent reports suggest obesity has a negative impact on clinical outcomes in patients with PDA. Pretreatment body mass index (BMI) and serum albumin (SA) have been shown to be associated with worse overall survival in patients with advanced and metastatic PDA. However, minimal data exists on the impact of BMI and SA on perioperative and long-term clinical outcomes in patients with early-stage resected PDA. Herein, we report on the impact of these variables on perioperative clinical outcomes, overall survival (OS) and disease free survival (DFS) in patients with resected PDA. With IRB approval, we evaluated 1,545 patients with PDA treated at a single institution from 2007-2013 and identified 106 patients who underwent upfront resection with curative intent. BMI and SA were calculated preoperatively and at the time of last clinical evaluation. Influence of preoperative BMI, SA, change in either variable, and influence of other clinical and pathologic variables on perioperative morbidity and mortality was assessed. The impact of these variables on DFS and OS was assessed with cox regression modeling and ANOVA. Actuarial estimates for DFS and OS were calculated using Kaplan-Meier methods. Median follow up time was 16 months (3-89). Mean age was 68 years. Median survival was 14 months (3-65) and median time to recurrence was 11 months (1-79). Length of hospital stay was associated with BMI (p = .023), change in BMI (p = .003) and SA (p = .004). Post-operative transfusion rate was associated with SA (p = .021). There was a strong correlation between BMI change and positive margin (p = .04) and lymph node status (p = .01). On multivariate analysis, change in SA (p = .03) and node positivity (p = .008) were associated with decreased DFS. Additionally, preoperative SA (p = .023), node positivity (p = .026) and poor differentiation (p = .045) were associated with worse OS on multivariate analysis. Low preoperative SA was associated

  8. Influence of Body Mass Index and Albumin on Perioperative Morbidity and Clinical Outcomes in Resected Pancreatic Adenocarcinoma.

    Directory of Open Access Journals (Sweden)

    Andrew Hendifar

    Full Text Available Obesity is a known risk factor for PDA and recent reports suggest obesity has a negative impact on clinical outcomes in patients with PDA. Pretreatment body mass index (BMI and serum albumin (SA have been shown to be associated with worse overall survival in patients with advanced and metastatic PDA. However, minimal data exists on the impact of BMI and SA on perioperative and long-term clinical outcomes in patients with early-stage resected PDA. Herein, we report on the impact of these variables on perioperative clinical outcomes, overall survival (OS and disease free survival (DFS in patients with resected PDA. With IRB approval, we evaluated 1,545 patients with PDA treated at a single institution from 2007-2013 and identified 106 patients who underwent upfront resection with curative intent. BMI and SA were calculated preoperatively and at the time of last clinical evaluation. Influence of preoperative BMI, SA, change in either variable, and influence of other clinical and pathologic variables on perioperative morbidity and mortality was assessed. The impact of these variables on DFS and OS was assessed with cox regression modeling and ANOVA. Actuarial estimates for DFS and OS were calculated using Kaplan-Meier methods. Median follow up time was 16 months (3-89. Mean age was 68 years. Median survival was 14 months (3-65 and median time to recurrence was 11 months (1-79. Length of hospital stay was associated with BMI (p = .023, change in BMI (p = .003 and SA (p = .004. Post-operative transfusion rate was associated with SA (p = .021. There was a strong correlation between BMI change and positive margin (p = .04 and lymph node status (p = .01. On multivariate analysis, change in SA (p = .03 and node positivity (p = .008 were associated with decreased DFS. Additionally, preoperative SA (p = .023, node positivity (p = .026 and poor differentiation (p = .045 were associated with worse OS on multivariate analysis. Low preoperative SA was

  9. Relationship between whole-body tumor burden, clinical phenotype, and quality of life in patients with neurofibromatosis.

    Science.gov (United States)

    Merker, Vanessa L; Bredella, Miriam A; Cai, Wenli; Kassarjian, Ara; Harris, Gordon J; Muzikansky, Alona; Nguyen, Rosa; Mautner, Victor F; Plotkin, Scott R

    2014-06-01

    Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis share a predisposition to develop multiple nerve sheath tumors. Previous studies have demonstrated that patients with NF1 and NF2 have reduced quality of life (QOL), but no studies have examined the relationship between whole-body tumor burden and QOL in these patients. We administered a QOL questionnaire (the SF-36) and a visual analog pain scale (VAS) to a previously described cohort of adult neurofibromatosis patients undergoing whole-body MRI. One-sample t-tests were used to compare norm-based SF-36 scores to weighted population means. Spearman correlation coefficients and multiple linear regression analyses controlling for demographic and disease-specific clinical variable were used to relate whole-body tumor volume to QOL scales. Two hundred forty-five patients (142 NF1, 53 NF2, 50 schwannomatosis) completed the study. Subjects showed deficits in selected subscales of the SF-36 compared to adjusted general population means. In bivariate analysis, increased tumor volume was significantly associated with pain in schwannomatosis patients, as measured by the SF-36 bodily pain subscale (rho = -0.287, P = 0.04) and VAS (rho = 0.34, P = 0.02). Regression models for NF2 patients showed a positive relationship between tumor burden and increased pain, as measured by the SF-36 (P = 0.008). Patients with NF1, NF2, and schwannomatosis suffer from reduced QOL, although only pain shows a clear relationship to patient's overall tumor burden. These findings suggest that internal tumor volume is not a primary contributor to QOL and emphasize the need for comprehensive treatment approaches that go beyond tumor-focused therapies such as surgery by including psychosocial interventions. PMID:24664633

  10. Alterations in body weight and biochemistry in patient treated with different psychotropic drugs in a clinic in Istanbul

    Directory of Open Access Journals (Sweden)

    Yeltekin Demirel,

    2009-08-01

    Full Text Available Aim Was to compare adult female patients receiving psychiatricdrugs with obese adult females who didn’t receive any drug treatmentwith respect to the alterations in body weight and biochemistry,and find out the contrubution of a team approach for the managementof these alterations.Methods A total of 102 female patients aged mean 40.9±12.4years who had been followed up and treated in the Psychiatry OutpatientClinics in Istanbul University for their psychiatric disordersand were complaining about increased body weight in thetreatment period were included. The controls were composed of261 females aged mean 39.8±13.0 years who had been referred byvarious departments to dietitians due to exogenous obesity but hadno endocrine-metabolic or psychiatric disorders or history of druguse. Initially, antropometric measurements and biochemical testswere performed for all patients.Results In the group receiving psychiatric treatment, the meanbody weight, BMI, waist and hip circumferences, body fat percentage(p<0.001; blood insulin, triglyceride, TSH, fibrinogenand homocysteine levels, and HOMA-IR were found to be higherthan those of the controls (p<0.05, whereas the total protein, albumin,zinc and folate levels were significantly lower (p<0.001.Conclusion The results of this study showed that patients whoneed psychopharmacotherapies were also more susceptible to severalmetabolic and cardiovascular disorders. Therefore, it wouldbe useful if psychiatric patients are treated with a multidisciplinaryteam approach consisting of an endocrinologist, psychiatrist and adietitian specialized in this area to prevent or delay the metabolicdisorders caused by psychiatric disorders and treatments.

  11. Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows

    Science.gov (United States)

    Sharifi, Reza; Hoedemaker, Martina

    2009-01-01

    The objective of this retrospective field study was to associate the type and smell of discharge, the size of the uterus, the ovarian and treatment status, and the time to diagnosis of animals with chronic clinical endometritis (CCE) with the incidence of ovarian cysts and with a marked loss in body condition in German Holstein Friesian cows. Two hundred and sixty-four cows diagnosed with CCE from day 14 to day 42 postpartum participated in this study. In addition, 100 days milk production and the parity of the animals were included in the analysis. With the use of logistic regression, a purulent vaginal discharge (≥ 50% pus), the decision not to treat the animals for CCE and a high 100 days milk production proved to be significant factors for the incidence of ovarian cysts. Additionally, the type of discharge showed interactions with the parity and the smell of the discharge, as more animals with fetid and purulent discharge and more animals in the first lactation with a purulent discharge developed ovarian cysts. A high milk production and the parity showed associations with an excessive body condition score loss. Additionally, more animals with a diagnosis of an oversized uterus in comparison to cows with an early involution experienced a considerable reduction in their nutritional condition. PMID:19934600

  12. Review of the Interaction Between Body Composition and Clinical Outcomes in Metastatic Renal Cell Cancer Treated With Targeted Therapies

    Directory of Open Access Journals (Sweden)

    Steven M Yip

    2016-03-01

    Full Text Available Treatment of metastatic renal cell cancer (mRCC currently focuses on inhibition of the vascular endothelial growth factor pathway and the mammalian target of rapamycin (mTOR pathway. Obesity confers a higher risk of RCC. However, the influence of obesity on clinical outcomes in mRCC in the era of targeted therapy is less clear. This review focuses on the impact of body composition on targeted therapy outcomes in mRCC. The International Metastatic Renal Cell Carcinoma Database Consortium database has the largest series of patients evaluating the impact of body mass index (BMI on outcomes in mRCC patients treated with targeted therapy. Overall survival was significantly improved in overweight patients (BMI ≥ 25 kg/m2, and this observation was externally validated in patients who participated in Pfizer trials. In contrast, sarcopenia is consistently associated with increased toxicity to inhibitors of angiogenesis and mTOR. Strengthening patients with mRCC and sarcopenia, through a structured exercise program and dietary intervention, may improve outcomes in mRCC treated with targeted therapies. At the same time, the paradox of obesity being a risk factor for RCC while offering a better overall survival in response to targeted therapy needs to be further evaluated.

  13. Clinical Feasibility of Using an EPID in cine Mode for Image-Guided Verification of Stereotactic Body Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To introduce a novel method for monitoring tumor location during stereotactic body radiotherapy (SBRT) while the treatment beam is on by using a conventional electronic portal imaging device (EPID). Methods and Materials: In our clinic, selected patients were treated under a phase I institutional review board-approved SBRT protocol for limited hepatic metastases from solid tumors. Before treatment planning multiple gold fiducial markers were implanted on the periphery of the tumor. During treatment the EPID was used in cine mode to collect the exit radiation and produce a sequence of images for each field. An in-house program was developed for calculating the location of the fiducials and their relative distance to the planned locations. Results: Three case studies illustrate the utility of the technique. Patient A exhibited a systematic shift of 4 mm during one of the treatment beams. Patient B showed an inferior drift of the target of approximately 1 cm from the time of setup to the end of the fraction. Patient C had a poor setup on the first day of treatment that was quantified and accounted for on subsequent treatment days. Conclusions: Target localization throughout each treatment beam can be quickly assessed with the presented technique. Treatment monitoring with an EPID in cine mode is shown to be a clinically feasible and useful tool

  14. Improved clinical status, quality of life, and walking capacity in Parkinson's disease after body weight-supported high-intensity locomotor training

    DEFF Research Database (Denmark)

    Rose, Martin Høyer; Løkkegaard, Annemette; Sonne-Holm, Stig;

    2013-01-01

    OBJECTIVE: To evaluate the effect of body weight-supported progressive high-intensity locomotor training in Parkinson's disease (PD) on (1) clinical status; (2) quality of life; and (3) gait capacity. DESIGN: Open-label, fixed sequence crossover study. SETTING: University motor control laboratory......±93 to 637±90m. CONCLUSIONS: Body weight-supported progressive high-intensity locomotor training is feasible and well tolerated by patients with PD. The training improved clinical status, quality of life, and gait capacity significantly....... during treadmill training. The training program contained combinations of (1) running and walking intervals, (2) the use of sudden changes (eg, in body weight support and speed), (3) different types of locomotion (eg, chassé, skipping, and jumps), and (4) sprints at 50 percent body weight. MAIN OUTCOME...

  15. CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part I (Diagnostics

    Directory of Open Access Journals (Sweden)

    O. V. Blagova

    2014-01-01

    Full Text Available PAim. To develop a comprehensive clinical and morphological approach to the nosological diagnosis and treatment of "idiopathic" arrhythmias (IA and the syndrome of dilated cardiomyopathy (DCM.Material and methods. Patients (n=320 with IA (n=190; 117 women, age 45.3±14.8 years and DCM (n=130, 41 women, age 46.9±12.5 years were included in the main group. 51 people (patients with ischemic heart disease; heart valve disease, hypertrophic cardiomyopathy, who underwent open-heart surgery; healthy volunteers were included in the control group. Along with the standard tests evaluation of the level of anti-heart antibodies (185 patients with IA and 122 with DCM, viral serology (166 and 122, multispiral computed tomography (42 and 88, cardiac magnetic resonance imaging (41 and 22, coronary angiography (19 and 54, myocardial biopsy/autopsy (19/0 and 33/9 were performed.Results. According to morphological study infectious-immune myocarditis was found in 78.9% of IA and 66.7% of DCM-patients, arrhythmogenic right ventricular dysplasia in 5.3% and 4.8% of patients, respectively. Other genetic cardiomyopathies, including combination with myocarditis were revealed in other patients. The frequency  of the viral genome detection in the myocardium in IA, DCM and the control group was 17.6%, 66.7% and 77.1%, respectively. However in the control group the incidence of myocarditis and anti-heart antibodies titers were significantly lower, while in the main group a strong correlation between myocarditis and anti-heart antibodies titers was found. The algorithm of noninvasive nosological diagnostics was developed; it allowed to verify diagnosis in 95% of IA patients and 89% DCM patients.Conclusion. Nosological cause of IA and DCM syndrome can be diagnosed in most patients by using an integrated clinical and morphological approach.

  16. CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part I (Diagnostics

    Directory of Open Access Journals (Sweden)

    O. V. Blagova

    2015-09-01

    Full Text Available PAim. To develop a comprehensive clinical and morphological approach to the nosological diagnosis and treatment of "idiopathic" arrhythmias (IA and the syndrome of dilated cardiomyopathy (DCM.Material and methods. Patients (n=320 with IA (n=190; 117 women, age 45.3±14.8 years and DCM (n=130, 41 women, age 46.9±12.5 years were included in the main group. 51 people (patients with ischemic heart disease; heart valve disease, hypertrophic cardiomyopathy, who underwent open-heart surgery; healthy volunteers were included in the control group. Along with the standard tests evaluation of the level of anti-heart antibodies (185 patients with IA and 122 with DCM, viral serology (166 and 122, multispiral computed tomography (42 and 88, cardiac magnetic resonance imaging (41 and 22, coronary angiography (19 and 54, myocardial biopsy/autopsy (19/0 and 33/9 were performed.Results. According to morphological study infectious-immune myocarditis was found in 78.9% of IA and 66.7% of DCM-patients, arrhythmogenic right ventricular dysplasia in 5.3% and 4.8% of patients, respectively. Other genetic cardiomyopathies, including combination with myocarditis were revealed in other patients. The frequency  of the viral genome detection in the myocardium in IA, DCM and the control group was 17.6%, 66.7% and 77.1%, respectively. However in the control group the incidence of myocarditis and anti-heart antibodies titers were significantly lower, while in the main group a strong correlation between myocarditis and anti-heart antibodies titers was found. The algorithm of noninvasive nosological diagnostics was developed; it allowed to verify diagnosis in 95% of IA patients and 89% DCM patients.Conclusion. Nosological cause of IA and DCM syndrome can be diagnosed in most patients by using an integrated clinical and morphological approach.

  17. Variabilidad morfológica y crecimiento corporal de cuatro poblaciones de Crocodylus moreletii en cautiverio Morphological variability and body growth on four populations of Crocodylus moreletii in captivity

    Directory of Open Access Journals (Sweden)

    Ricardo Serna-Lagunes

    2010-12-01

    Full Text Available El objetivo del trabajo fue evaluar la variabilidad morfológica y el crecimiento corporal de 4 poblaciones del cocodrilo de pantano (Crocodylus moreletii que se encuentran en la Unidad de Manejo para la Conservación de la Vida Silvestre Cacahuatal ubicada en el estado de Veracruz, México. Se compararon 4 poblaciones: 2 poblaciones cuyos individuos nacieron en vida silvestre y 2 que nacieron en cautiverio. Los rasgos morfológicos estudiados fueron similares entre poblaciones y entre sexos. Las tasas de crecimiento corporal fueron significativamente diferentes entre poblaciones. Los individuos que nacieron en condiciones naturales crecieron más rápidamente que los nacidos en cautiverio. Se concluye que el cautiverio no parece afectar la expresión morfológica, pero sí la tasa de crecimiento corporal. Estos resultados muestran que diferentes poblaciones de C. moreletii pueden presentar un crecimiento diferencial determinado por las condiciones de cautiverio.The main goal of this study was to evaluate the effect of captivity upon morphological characteristics and body growth rates of the Morelet's crocodile (Crocodylus moreletii. The studied individuals are currently reared in the Management Unit for Wildlife Conservation (Cacahuatal, located at Veracruz, Mexico. Four populations were compared: individuals from 2 of them were born in wild conditions, whereas individuals from the other 2, were born in captivity. Morphology was similar among populations and between sexes. Body growth rates were significantly different among populations, those individuals born in natural conditions grew faster than those born in captivity. We conclude that captivity does not seem to affect the morphological expression of C. moreletii in comparison with a significant effect upon the rate of body growth. These results show that different populations of C. moreletii can exhibit differential body growth patterns depending on the conditions experienced in captivity.

  18. Evaluation of the Clinical Relevance of Body Composition Parameters in Patients with Cancer Metastatic to the Liver Treated with Hepatic Arterial Infusion Chemotherapy

    OpenAIRE

    Parsons, Henrique A.; Apostolia M Tsimberidou; Pontikos, Michael; Fu, Siqing; Hong, David; Wen, Sijin; Baracos, Vickie E; Kurzrock, Razelle

    2012-01-01

    The association between body composition parameters and toxicity associated with hepatic arterial infusion (HAI) chemotherapy regimens has not been analyzed. We analyzed data from patients with advanced cancer and liver metastases treated on a clinical trial of HAI oxaliplatin combination regimen. Patient characteristics, response and toxicities were analyzed in relevance with body composition data from CT images. Forty-eight of 57 patients (mean age 57 years; 60% women) had available CT scan...

  19. Effects of water body morphology on nutrients concentration and phytoplankton biomass%水体形态与浮游植物生物量和营养盐含量的相关性研究

    Institute of Scientific and Technical Information of China (English)

    林喜茂; 赵虎虎; 张海平

    2012-01-01

    Nutrient concentration and phytoplankton biomass in an enclosed water body, Yingdong south lake, Shanghai Chongming island, were monitored from August 2010 to September 2011. The effect of water body morphology on eutrophication was investigated. The results showed that different types of morphology exert dissimilar influence on eutrophication process in waters. In the rive-type water, flow turbulence was relatively weak, which was in favor of phytoplankton growth under a suitable water temperature circumstance. While in the lake-type water body, the relatively strong flow turbulence might inhibit phytoplankton growth. Multivariate statistical analysis showed that the process of the phytoplankton growth and decline might be the main influencing factor of nutrients in these waters. It could be concluded that the morphology of enclosed water had certain effect on nutrient concentration and phytoplankton biomass. Therefore, more attention should be paid on the water body morphology in design and reconstruction of enclosed water bodies to avoid eutrophication problems.%以封闭性水体上海崇明岛赢东村南湖为对象,从2010年8月到2011年9月进行了为期一年的现场观测,分析了2种不同形态水体(线型水体和面型水体)中的营养盐含量和浮游植物生物量,探讨了水体形态对富营养化的影响.结果表明,线型水体的紊动较弱,在水温适宜时更利于浮游植物的生长,而面型水体的紊动相对较强,浮游植物生长受到一定限制;多元统计分析结果进一步表明,在封闭性水体中浮游植物的生消过程可能是引起水体营养盐含量变化的关键因素;封闭性水体的水体形态对浮游植物生物量及营养盐浓度存在较大影响.鉴于此,在进行景观水体规划、设计及城市河道改造时,应该在水体形态的选择上给予更多关注.

  20. CLINICAL APPLICATION OF BODY DIFFUSION WEIGHTED MR IMAGING IN THE DIAGNOSIS AND PREOPERATIVE N STAGING OF CERVICAL CANCER

    Institute of Scientific and Technical Information of China (English)

    Hua-dan Xue; Shuo Li; Fei Sun; Hong-yi Sun; Zheng-yu Jin; Jia-xin Yang; Mei Yu

    2008-01-01

    Objective To evaluate the clinical impact of body diffusion weighted imaging (DWI) on the diagnosis and preoperative N staging of cervical cancer. Methods Twenty-four patients (mean age 37.9 years old) with proved cervical cancer by cervical biopsy and 24 female patients with other suspected pelvic abnormalities received preoperative body DWI scan. Results of body DWI were compared with pathological findings. The apparent diffusion coefficient (ADC) values of normal cervix and different pathological types of cervical cancer were compared. ADC value of normal or inflammatory lymph nodes was also compared with that of metastatic ones. Student's t test was used for statistical analysis. Results There were 5 adenocarcinomas and 19 epitheliomas showed with biopsy results, and DWI showed 21 cervical lesions out of them (87.5%). ADC values of the normal cervix (n = 24), epithelioma (n = 19), and adenocar-cinoma (n = 5)were (1.73 ± 0.31) ×10-3, (0.88 ± 0.22)×1O-3, and (1.08 ± 0.12)×10-3 mm2/s, respectively. Statistical analysis showed significant difference in ADC value between normal cervical tissue and either tumor tissues (both P < 0.01). In patients had lymphadenectomy (n = 24), totally 67 lymph nodes including 16 metastatic lymph nodes were pathologically analyzed, and DWI showed 66 (98.5%) out of them. ADC values of normal/inflammatory and metastatic lymph nodes were (1.07 ± 0.16) ×10-3 and (0.77 ± 0.13)×10-3 mm2/s (P < 0.01). Receiver operating characteristic (ROC) curve of ADC value of metastatic lymph node showed that area under curve was 0.961. Conclusions ADC value in cervical carcinoma is lower than that in normal cervix, and ADC may have predictive value in subtype discrimination. ADC value may improve the preoperative characterization of lymph node metastasis. And at least abdominal and pelvic DWI scan is suggested for N staging evaluation in such patients.

  1. Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals.

    Directory of Open Access Journals (Sweden)

    Leay-Kiaw Er

    Full Text Available Insulin resistance (IR and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG levels or adiposity status for determining their efficiency as independent risk factors for IR.We enrolled 511 Taiwanese individuals for the analysis. The clinical usefulness of various parameters--such as traditional lipid levels and ratios; visceral adiposity indicators, visceral adiposity index (VAI, and lipid accumulation product (LAP; the product of triglyceride (TG and FPG (the TyG index; TyG with adiposity status (TyG-body mass index [BMI] and TyG-waist circumference index [WC]; and adipokine levels and ratios--was analyzed to identify IR.For all lipid ratios, the TG/high-density lipoprotein cholesterol (HDL-C ratio had the highest additional percentage of variation in the homeostasis model assessment of insulin resistance (HOMA-IR; 7.0% in total; for all variables of interest, TyG-BMI and leptin-adiponectin ratio (LAR were strongly associated with HOMA-IR, with 16.6% and 23.2% of variability, respectively. A logistic regression analysis revealed similar patterns. A receiver operating characteristic (ROC curve analysis indicated that TG/HDL-C was a more efficient IR discriminator than other lipid variables or ratios. The area under the ROC curve (AUC for VAI (0.734 and TyG (0.708 was larger than that for TG/HDL-C (0.707. TyG-BMI and LAR had the largest AUC (0.801 and 0.801, respectively.TyG-BMI is a simple, powerful, and clinically useful surrogate marker for early identification of IR.

  2. The Morphologic Profile of HPV-Related Head and Neck Squamous Carcinoma: Implications for Diagnosis, Prognosis, and Clinical Management

    OpenAIRE

    Westra, William H.

    2012-01-01

    Much recent attention has highlighted a subset of head and neck squamous cell carcinomas (HNSCCs) related to the human papillomavirus (HPV) that is characterized by an epidemiologic, demographic, and clinical profile that deviates from the profile of conventional non-HPV-related HNSCC. Lost in the dash to develop and implement diagnostic assays to detect the presence of HPV in HNSCCs is the unpretentious observation that these HPV-HNSCCs are also distinctive with respect to their microscopic ...

  3. NeuroRex: A Clinical Neural Interface Roadmap for EEG-based Brain Machine Interfaces to a Lower Body Robotic Exoskeleton*

    OpenAIRE

    Jose L. Contreras-Vidal; Grossman, Robert G.

    2013-01-01

    In this communication, a translational clinical brain-machine interface (BMI) roadmap for an EEG-based BMI to a robotic exoskeleton (NeuroRex) is presented. This multi-faceted project addresses important engineering and clinical challenges: It addresses the validation of an intelligent, self-balancing, robotic lower-body and trunk exoskeleton (Rex) augmented with EEG-based BMI capabilities to interpret user intent to assist a mobility-impaired person to walk independently. The goal is to impr...

  4. 血涂片细胞形态检查在初诊患者临床诊断中的应用%Blood smear the application of the cell morphology was in clinical diagnosis

    Institute of Scientific and Technical Information of China (English)

    滕瑞军

    2015-01-01

    Objective To study the blood smear cells form to check the application result was in clinical diagnosis. Meth-ods Selecting in June 2013 to May 2014, our hospital 380 cases of patients with both the fever, adopt blood smear cell morpho-logical examination, observation of red blood cells, white blood cells, platelets, smear tail abnormal morphology and abnormal cells. Results 380 patients in the final diagnosis of 136 cases of bacterial infection, blood routine examination is normal, the blood smears neutrophil particles in plasma and enlargement, and poisoning phenomenon; 45 cases of iron-deficiency anaemia, the red blood cells form is differ, the cell body is small, light colored areas significantly increased; Giant cell anemia in 59, ma-ture red blood cells form is differ, the main oval, big cell body; Myelodysplastic syndrome 32 cases, red blood cell sizes, see more huge platelets and polymorphic, abnormal red blood cells; 45 cases of acute leukemia, immature cells, red blood cells. conclusion The blood smear cell morphological examination to observe the platelets, white blood cells and red blood cell mor-phology, preliminarily determine whether patients are blood disease, bacterial infection, anemia, such as simple operation, easy to grasp, was to the patient's clinical diagnosis is of high value.%目的:探讨血涂片细胞形态检查在初诊患者临床诊断中的应用效果。方法选取2013年6月至2014年5月我院收治的初诊发热患者380例,均采用血涂片细胞形态检查,观察红细胞、白细胞、血小板形态、涂片尾部细胞异常形态和异常物。结果380例患者中最终确诊细菌感染136例,血常规检查正常,血涂片检查中性粒细胞浆内颗粒增粗、增多和中毒现象;缺铁性贫血45例,红细胞形态不一,胞体较小,淡染区明显扩大;巨幼细胞性贫血59例,成熟红细胞形态不一,主要呈椭圆形,胞体偏大;骨髓增生异常综合征32例,红

  5. Microskin autografting in the treatment of burns over 70% of total body surface area: 14 years of clinical experience.

    Science.gov (United States)

    Chen, Xu-Lin; Liang, Xun; Sun, Li; Wang, Fei; Liu, Sheng; Wang, Yong-Jie

    2011-09-01

    Despite the fact that early excision and grafting have significantly improved burn outcomes, the management of severely burned patients whose burn size exceeds 70% total body surface area (TBSA) still represents a big challenge for burn surgeons all over the world. During the period of 1997-2010 at our centre, aggressive excision and microskin autografting were performed in 63 severely burned patients. Their burn sizes ranged from 70% to 98% TBSA with a mean of 84.9%. The average full-thickness burn was 66.3% (range, 29-94%). Thirty patients had concomitant inhalation injury. Two to 7 days after burn, these patients underwent aggressive excisions ranging from 25% to 60% TBSA and transplantation of microskin autograft overlaid with allograft. The ratios of donor-site to recipient-site surface area were between 1:6 and 1:18. Signs of epithelialization were shown within 35-55 days. The wound healing rate was 74.9% (176/235), with 51.1% of cases (120/235) healing completely and 23.8% (56/235) improving. Microskin autografting yielded an overall survival rate of 63.5%; only 23 patients died. Our clinical experience in using the microskin autografting for burn coverage suggests that the technique is very effective in covering extensive burns, and that it is particularly useful when graft donor sites are very limited due to its high utilization rate of donor site. The factors affecting the outcome of microskin autografting are discussed herein.

  6. The mitochondrial phylogeny of an ancient lineage of ray-finned fishes (Polypteridae with implications for the evolution of body elongation, pelvic fin loss, and craniofacial morphology in Osteichthyes

    Directory of Open Access Journals (Sweden)

    Brandley Matthew C

    2010-01-01

    Full Text Available Abstract Background The family Polypteridae, commonly known as "bichirs", is a lineage that diverged early in the evolutionary history of Actinopterygii (ray-finned fish, but has been the subject of far less evolutionary study than other members of that clade. Uncovering patterns of morphological change within Polypteridae provides an important opportunity to evaluate if the mechanisms underlying morphological evolution are shared among actinoptyerygians, and in fact, perhaps the entire osteichthyan (bony fish and tetrapods tree of life. However, the greatest impediment to elucidating these patterns is the lack of a well-resolved, highly-supported phylogenetic tree of Polypteridae. In fact, the interrelationships of polypterid species have never been subject to molecular phylogenetic analysis. Here, we infer the first molecular phylogeny of bichirs, including all 12 recognized species and multiple subspecies using Bayesian analyses of 16S and cyt-b mtDNA. We use this mitochondrial phylogeny, ancestral state reconstruction, and geometric morphometrics to test whether patterns of morphological evolution, including the evolution of body elongation, pelvic fin reduction, and craniofacial morphology, are shared throughout the osteichthyan tree of life. Results Our molecular phylogeny reveals 1 a basal divergence between Erpetoichthys and Polypterus, 2 polyphyly of P. endlicheri and P. palmas, and thus 3 the current taxonomy of Polypteridae masks its underlying genetic diversity. Ancestral state reconstructions suggest that pelvic fins were lost independently in Erpetoichthys, and unambiguously estimate multiple independent derivations of body elongation and shortening. Our mitochondrial phylogeny suggested species that have lower jaw protrusion and up-righted orbit are closely related to each other, indicating a single transformation of craniofacial morphology. Conclusion The mitochondrial phylogeny of polypterid fish provides a strongly

  7. Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients.

    Science.gov (United States)

    Yalcinkaya, Ulviye; Doganavsargil, Basak; Sezak, Murat; Kececi, Burcin; Argin, Mehmet; Basdemir, Gulcin; Oztop, Fikri

    2014-12-01

    Osteoid osteoma and osteoblastoma are histologically similar, benign bone-forming tumors. In this retrospective study, we aimed to evaluate the natural history; clinical, pathologic, and radiologic findings; and treatment results in 204 patients between 1959 and 2006 in a single institution. According to the World Health Organization's definition, tumors ≤1 cm in diameter were classified as osteoid osteoma, and those ≥2 cm, as osteoblastoma. For tumors between 1 cm and 2 cm, other criteria, such as the bone involved, the site, the presence of a nidus, and presence of peripheral sclerosis, were used for diagnosis. There were 131 patients with osteoid osteoma (93 male, 38 female) and 73 patients with osteoblastoma (40 male, 33 female). The mean age in the osteoid osteoma and osteoblastoma groups was 16.4 ± 7 and 19.6 ± 9.9 years, respectively. The osteoid osteoma cases were mostly localized in the extremities, whereas the osteoblastoma cases involved the vertebral column and sacrum. The nidus size varied between 0.2 and 1.5 cm in osteoid osteoma cases, and the tumor size range was 1.3-10 cm in the osteoblastoma cases. The pain was encountered in 89% of osteoid osteoma and 45% of osteoblastoma patients. Histopathology was similar in both cases. The treatment of choice was conservative surgery for both diagnoses. In conclusion, osteoblastoma is clinically and radiologically more aggressive than osteoid osteoma.

  8. Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix – Correlation of morphological MRI, biochemical T2 mapping and clinical outcome

    International Nuclear Information System (INIS)

    Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart™II, a second generation matrix-assisted implantation system. Methods: Thirty-one patients were recruited 6–49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. Results: IKDC score significantly correlated with MOCART score (r = −0.39, p = 0.031), inversely correlated with previous interventions (r = −0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). T2 values were significantly lower in patients with longer duration implants (p < 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. Conclusions: Significant improvement with time from BioCart™II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure.

  9. Postsplenectomy sclerosing extramedullary hematopoietic tumor with unexpected good clinical evolution: morphologic, immunohistochemical, and molecular analysis of one case and review of the literature.

    Science.gov (United States)

    Gualco, Gabriela; Ojopi, Elida B P; Chioato, Lucimara; Cordeiro, Danielle Leão; Negretti, Fabio; Bacchi, Carlos E

    2010-05-01

    Sclerosing extramedullary hematopoietic tumor has been described as a rare manifestation of chronic myeloproliferative neoplasm. The lack of knowledge about this entity has caused it to be mistaken for many types of nonhematopoietic and hematopoietic tumors. We present the case of a 71-year-old lady with a long history of primary myelofibrosis, which developed multiple abdominal sclerosing extramedullary hematopoietic tumors with good clinical evolution. Nonchronic myeloid leukemia myeloproliferative neoplasm included a JAK2 mutation as part of the diagnosis algorithm. Particularly, idiopathic myelofibrosis is related with a JAK2 mutation in 50% of the cases with a pejorative prognosis. The absence of JAK2 demonstrated in the paraffin samples of the tumors may be related to the unusual evolution in this particular case. Morphologically differential diagnoses considered in the evaluation of this entity and in our case included sarcomas mainly liposarcoma, anaplastic carcinoma, and Hodgkin lymphoma.

  10. The impacts of aerobic exercise and mind-body exercise (yoga) on neuro-cognition and clinical symptoms in early psychosis : a single-blind randomized controlled clinical trial

    OpenAIRE

    Lin, Jingxia; 林晶霞

    2013-01-01

    Motivation Impairments of attention and memory are detectable in early psychosis, and often result in severe, longstanding functional impairments. Pharmacological interventions for cognitive impairments have been largely unsuccessful. The current study aims to explore the effects of aerobic exercise and mind-body exercise (yoga) on cognitive functioning and clinical symptoms in female patients with early psychosis. The potential neuromechanism underlying the clinical consequences was also...

  11. Relationship between dental morphology, sex, body length and age in Pontoporia blainvillei and Sotalia fluviatilis (Cetacea) in Northern Rio de Janeiro, Brazil Relação entre a morfologia dental, sexo, comprimento do corpo e idade em Pontoporia blainvillei e Sotalia fluviatilis (Cetacea) no Norte do Rio de Janeiro, Brasil

    OpenAIRE

    RAMOS R. M. A.; DI BENEDITTO A. P. M.; LIMA N. R. W.

    2000-01-01

    The relationship between dental morphology, sex, body length and age of small cetaceans can be used to determine ontogeny, sexual dimorphism and geographical variation. The objective of this study was to determine the relationship between dental morphology, sex, body size and age. A total of 91 specimens of P. blainvillei and 80 specimens of S. fluviatilis accidentally captured in fisheries or stranded in northern Rio de Janeiro (21º37'-22º25'S), from September 1988 to November 1996 were anal...

  12. CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part II (Treatment

    Directory of Open Access Journals (Sweden)

    O. V. Blagova

    2014-01-01

    Full Text Available Part I (Diagnostics, was published in the journal “Rational Pharmacotherapy in Cardiology” 2014;10(1:62-72Aim. To develop a comprehensive clinical and morphological approach to the nosological diagnosis and treatment of "idiopathic" arrhythmias (IA and the syndrome of dilated cardiomyopathy (DCM.Material and methods. Patients (n=320 with IA (n=190; 117 women, age 45.3±14.8 years and DCM (n=130, 41 women, age 46.9±12.5 years were included in the main group. 51 people (patients with ischemic heart disease; heart valve disease, hypertrophic cardiomyopathy, who underwent open-heart surgery; healthy volunteers were included in the control group. Along with the standard tests evaluation of the level of anti-heart antibodies (185 patients with IA and 122 with DCM, viral serology (166 and 122, multispiral computed tomography (42 and 88, cardiac magnetic resonance imaging (41 and 22, coronary angiography (19 and 54, myocardial biopsy/autopsy (19/0 and 33/9 were performed.Results. According to morphological study infectious-immune myocarditis was found in 78.9% patients with IA and 66.7% patients with DCM, arrhythmogenic right ventricular dysplasia in 5.3% and 4.8% of patients, respectively. Other genetic cardiomyopathies, including combination with myocarditis were revealed in other patients. The frequency of the viral genome detection in the myocardium in IA, DCM and the control group was 17.6%, 66.7% and 77.1%, respectively. However in the control group the incidence of myocarditis and anti-heart antibodies titers were significantly lower than in the main group, where a strong correlation between myocarditis and anti-heart antibodies titers was found. The algorithm of noninvasive nosological diagnostics was developed; it allowed to verify diagnosis in 95% of IA patients and 89% DCM patientsThe basic therapy (antiviral drugs, corticosteroids, hydroxychloroquine, azathioprine was performed in some patients with myocarditis. Improving of the

  13. CLINICAL AND MORPHOLOGICAL APPROACH TO DIAGNOSIS OF "IDIOPATHIC" ARRHYTHMIAS AND DILATED CARDIOMYOPATHY SYNDROME AS A BASIS FOR DIFFERENTIATED THERAPY. Part II (Treatment

    Directory of Open Access Journals (Sweden)

    O. V. Blagova

    2015-09-01

    Full Text Available Part I (Diagnostics, was published in the journal “Rational Pharmacotherapy in Cardiology” 2014;10(1:62-72Aim. To develop a comprehensive clinical and morphological approach to the nosological diagnosis and treatment of "idiopathic" arrhythmias (IA and the syndrome of dilated cardiomyopathy (DCM.Material and methods. Patients (n=320 with IA (n=190; 117 women, age 45.3±14.8 years and DCM (n=130, 41 women, age 46.9±12.5 years were included in the main group. 51 people (patients with ischemic heart disease; heart valve disease, hypertrophic cardiomyopathy, who underwent open-heart surgery; healthy volunteers were included in the control group. Along with the standard tests evaluation of the level of anti-heart antibodies (185 patients with IA and 122 with DCM, viral serology (166 and 122, multispiral computed tomography (42 and 88, cardiac magnetic resonance imaging (41 and 22, coronary angiography (19 and 54, myocardial biopsy/autopsy (19/0 and 33/9 were performed.Results. According to morphological study infectious-immune myocarditis was found in 78.9% patients with IA and 66.7% patients with DCM, arrhythmogenic right ventricular dysplasia in 5.3% and 4.8% of patients, respectively. Other genetic cardiomyopathies, including combination with myocarditis were revealed in other patients. The frequency of the viral genome detection in the myocardium in IA, DCM and the control group was 17.6%, 66.7% and 77.1%, respectively. However in the control group the incidence of myocarditis and anti-heart antibodies titers were significantly lower than in the main group, where a strong correlation between myocarditis and anti-heart antibodies titers was found. The algorithm of noninvasive nosological diagnostics was developed; it allowed to verify diagnosis in 95% of IA patients and 89% DCM patientsThe basic therapy (antiviral drugs, corticosteroids, hydroxychloroquine, azathioprine was performed in some patients with myocarditis. Improving of the

  14. Impact of Body Mass Index on the Clinical Outcomes after Percutaneous Coronary Intervention in Patients ≥75 Years Old

    Institute of Scientific and Technical Information of China (English)

    Pei-Yuan He; Yue-Jin Yang; Shu-Bin Qiao; Bo Xu; Min Yao; Yong-Jian Wu; Yuan Wu

    2015-01-01

    Background:The impact of body mass index (BMI) on the clinical outcomes after percutaneous coronary intervention (PCI) in patients ≥75 years old remained unclear.Methods:A total of 1098 elderly patients undergoing PCI with stent implantation were recruited.Patients were divided into four groups by the value of BMI:Underweight (<20.0 kg/m2),normal weight (20.0-24.9 kg/m2),overweight (25.0-29.9 kg/m2) and obese (≥30.0 kg/m2).Major clinical outcomes after PCI were compared between the groups.The primary endpoint was defined as in-hospital major adverse cardiovascular events (MACEs),which included death,myocardial infarction (MI) and target vessel revascularization.The secondary endpoint was defined as 1 year death.Logistic regression analysis was performed to adjust for the potential confounders.Results:Totally,1077 elderly patients with available BMIs were included in the analysis.Patients of underweight,normal weight,overweight and obese accounted for 5.6%,45.4%,41.5% and 7.5% of the population,respectively.Underweight patients were more likely to attract ST-segment elevation MI,and get accompanied with anemia or renal dysfunction.Meanwhile,they were less likely to achieve thrombolysis in MI 3 grade flow after PCI,and receive beta-blocker,angiotensin converting enzyme inhibitor or angiotensin receptor blocker after discharge.In underweight,normal weight,overweight and obese patients,in-hospital MACE were 1.7%,2.7%,3.8%,and 3.7% respectively (P =0.68),and 1 year mortality rates were 5.0%,3.9%,5.1% and 3.7% (P =0.80),without significant difference between the groups.Multivariate regression analysis showed that the value of BMI was not associated with in-hospital MACE in patients at 75 years old.Conclusions:The BMI "obese paradox" was not found in patients ≥75 years old.It was suggested that BMI may not be a sensitive predictor of adverse cardiovascular events in elderly patients.

  15. Lower late-life body-mass index is associated with higher cortical amyloid burden in clinically normal elderly

    Science.gov (United States)

    Hsu, David C.; Mormino, Elizabeth C.; Schultz, Aaron P.; Amariglio, Rebecca E.; Donovan, Nancy J.; Rentz, Dorene M.; Johnson, Keith A.; Sperling, Reisa A.; Marshall, Gad A.

    2016-01-01

    Background Lower body-mass index (BMI) in late life has been associated with an increased risk of dementia, and weight loss has been associated with more rapid decline in Alzheimer disease (AD) dementia. Objective To explore the association between BMI and cortical amyloid burden in clinically normal (CN) elderly at risk for AD dementia. Methods Cross-sectional analyses were completed using baseline data from the Harvard Aging Brain Study, consisting of 280 community-dwelling CN older adults aged 62–90. Assessments included medical histories and physical exam, Pittsburgh compound B (PiB) positron emission tomography (PET) amyloid imaging, and apolipoprotein E ɛ4 (APOE4) genotyping. For the primary analysis, a general linear regression model was used to evaluate the association of BMI with PiB retention. Covariates included age, sex, years of education, and APOE4 carrier status. Secondary analyses were performed for BMI subdivisions (normal, overweight, obese), APOE4 carriers, and BMI × APOE4 interaction. Results In the primary analysis, greater PiB retention was associated with lower BMI (β=−0.14, p=0.02). In the secondary analyses, APOE4 carrier status (β=−0.27, p=0.02) and normal BMI (β=−0.25, p=0.01), as opposed to overweight or obese BMI, were associated with greater PiB retention. The BMI × APOE4 interaction was also significant (β=−0.14, p=0.04). Conclusions This finding offers new insight into the role of BMI at the preclinical stage of AD, wherein lower BMI late in life is associated with greater cortical amyloid burden. Future studies are needed to elucidate the mechanism behind this association, especially in those with lower BMI who are APOE4 carriers. PMID:27340843

  16. Turbo STIR magnetic resonance imaging as a whole-body screening tool for metastases in patients with breast carcinoma: preliminary clinical experience.

    Science.gov (United States)

    Walker, R; Kessar, P; Blanchard, R; Dimasi, M; Harper, K; DeCarvalho, V; Yucel, E K; Patriquin, L; Eustace, S

    2000-04-01

    This study was undertaken to assess the utility of whole-body turbo short tau inversion recovery (STIR) magnetic resonance imaging (MRI) to detect metastases to liver, brain, and bone as a single examination in women with breast cancer. Seventeen patients with biopsy-proven breast cancer and suspected metastatic disease attending over a 12-month period referred for both conventional imaging and whole-body MRI were included in the study. Three patients were found to be free of metastases at both conventional and MR imaging. Appendicular or axial skeletal metastases were identified in 11 of 17 patients, with correlation between findings at whole-body MRI and scintigraphy in 15 of the 17 patients. Five patients had evidence of hepatic metastases on whole-body MRI, of which metastases were identified in only three patients at CT despite contrast enhancement. Four patients had brain abnormalities (metastases in three patients, meningioma in one patient) detected on both whole-body and dedicated brain MRI. Preliminary clinical experience suggests that turbo STIR whole-body MRI may represent a convenient and cost-effective method of total body screening for metastases in patients with breast carcinoma.

  17. The Aberrant Right Subclavian Artery (Arteria Lusoria: The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    Directory of Open Access Journals (Sweden)

    Michał Polguj

    2014-01-01

    Full Text Available The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria. If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9±19.4 years for all patients but 54.0±19.6 years and 44.9±18.1 years for female and male subjects, respectively (P=0.0061. The most common symptoms in this group were dysphagia (71.2%, dyspnea (18.7%, retrosternal pain (17.0%, cough (7.6%, and weight loss (5.9%. The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%, Kommerell’s diverticulum (14.9%, aneurysm of the artery itself (12.8%, and a right sided aortic arch (9.2%. In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss.

  18. The Aberrant Right Subclavian Artery (Arteria Lusoria): The Morphological and Clinical Aspects of One of the Most Important Variations—A Systematic Study of 141 Reports

    Science.gov (United States)

    Chrzanowski, Łukasz; Kasprzak, Jarosław D.; Stefańczyk, Ludomir; Topol, Mirosław; Majos, Agata

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9 ± 19.4 years for all patients but 54.0 ± 19.6 years and 44.9 ± 18.1 years for female and male subjects, respectively (P = 0.0061). The most common symptoms in this group were dysphagia (71.2%), dyspnea (18.7%), retrosternal pain (17.0%), cough (7.6%), and weight loss (5.9%). The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%), Kommerell's diverticulum (14.9%), aneurysm of the artery itself (12.8%), and a right sided aortic arch (9.2%). In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss. PMID:25105156

  19. The aberrant right subclavian artery (arteria lusoria): the morphological and clinical aspects of one of the most important variations--a systematic study of 141 reports.

    Science.gov (United States)

    Polguj, Michał; Chrzanowski, Łukasz; Kasprzak, Jarosław D; Stefańczyk, Ludomir; Topol, Mirosław; Majos, Agata

    2014-01-01

    The most important abnormality of the aortic arch is arguably the presence of an aberrant right subclavian artery (arteria lusoria). If this vessel compresses the adjacent structures, several symptoms may be produced. The aim of the study is to present the morphological and clinical aspects of the aberrant right subclavian artery. Three different databases searched for a review of pertinent literature using strictly predetermined criteria. Of 141 cases, 15 were cadaveric and 126 were clinically documented. The gender distribution of the subjects was 55.3% female and 44.7% male. The mean age of the patients at symptoms onset was 49.9 ± 19.4 years for all patients but 54.0 ± 19.6 years and 44.9 ± 18.1 years for female and male subjects, respectively (P = 0.0061). The most common symptoms in this group were dysphagia (71.2%), dyspnea (18.7%), retrosternal pain (17.0%), cough (7.6%), and weight loss (5.9%). The vascular anomalies coexisting with an arteria lusoria were truncus bicaroticus (19.2%), Kommerell's diverticulum (14.9%), aneurysm of the artery itself (12.8%), and a right sided aortic arch (9.2%). In conclusion, compression of adjacent structures by an aberrant right subclavian artery needs to be differentiated from other conditions presenting dysphagia, dyspnea, retrosternal pain, cough, and weight loss. PMID:25105156

  20. Imaging body composition in cancer patients: visceral obesity, sarcopenia and sarcopenic obesity may impact on clinical outcome

    OpenAIRE

    Yip, Connie; Dinkel, Charlotte; Mahajan, Abhishek; Siddique, Musib; Cook, Gary J.R.; Goh, Vicky

    2015-01-01

    Abstract In recent years, there has been increasing interest in the influence of body composition on oncological patient outcomes. Visceral obesity, sarcopenia and sarcopenic obesity have been identified as adverse factors in cancer patients. Imaging quantification of body composition such as lean muscle mass and fat distribution is a potentially valuable tool. This review describes the following imaging techniques that may be used to assess body composition: dual-energy X-ray absorptiometry ...

  1. Correlation between volume and morphological changes in the hippocampal formation in Alzheimer's disease: rounding of the outline of the hippocampal body on coronal MR images

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Michito; Sato, Takamichi [Ohshima Clinic, Department of Radiology, Yamagata (Japan); Kawakatsu, Shinobu [Yamagata University School of Medicine, Department of Psychiatry, Yamagata (Japan); Ohshima, Fumi [Ohshima Clinic, Department of Neurology, Yamagata (Japan)

    2012-10-15

    The aim of this study was to investigate whether the outline of the hippocampal body becomes rounded on coronal magnetic resonance imaging (MRI) as the volume of the hippocampal formation decreases in Alzheimer's disease (AD). Institutional review board approval of the study protocol was obtained, and all subjects provided informed consent for the mini-mental state examination (MMSE) and MRI. The MRI and MMSE were prospectively performed in all 103 subjects (27 men and 76 women; mean age {+-} standard deviation, 77.7 {+-} 7.8 years) who had AD or were concerned about having of dementia and who consulted our institute over 1 year. The subjects included 14 non-dementia cases (MMSE score {>=} 28) and 89 AD cases (MMSE score {<=} 27). The total volume of the bilateral hippocampal formation (VHF) was assessed with a tracing method, and the ratio of the VHF to the intracranial volume (RVHF) and the rounding ratio (RR) of the hippocampal body (mean ratio of its short dimension to the long dimension in the bilateral hippocampal body) were calculated. Using Spearman's correlation coefficient, the correlations between RR and VHF and between RR and RVHF were assessed. Correlation coefficients between RR and VHF and between RR and RVHF were -0.419 (p < 0.01) and -0.418 (p < 0.01), respectively. There was a significant negative correlation between RR and the volume of the hippocampal formation. The outline of the body of the hippocampal formation becomes rounded on coronal images as its volume decreases in AD. (orig.)

  2. IMMUNOLOGICAL AND MORPHOLOGICAL PREDICTORS OF CLINICAL HETEROGENEITY OF PATIENTS WITH GRAVES' DISEASE (BASED ON RESEARCH OF THE THYROID GLAND OPERATIONAL MATERIAL

    Directory of Open Access Journals (Sweden)

    T. V. Saprina

    2015-01-01

    Full Text Available Very little research is devoted to the study of communication systemic immunological changes and local immunological changes in the tissue of the thyroid in autoimmune thyrophaties. The goal of the research was to establish immunologic and morphologic predictors of clinical course and functional outcomes of Graves’s disease (GD.Material and methods. We examined 45 patients with GD (14 men and 31 women aged 18–55 years (47.0 (35.0–53.0 years, matching the following criteria: a verified diagnosis GD, accommodation in Tomsk oblast and the Tomsk not less than 10 years, the patient's consent for the study. The control group included 30 people, with an average age of (45.3 ± 5.6 years and was comparable by age and sex with GD patients. The study included: definition of the standard for GD hormonal and serological profile (free T4, free T3, and TSH, antibodies to TPO, antibodies to the TSH receptor, the cultivation of mononuclear leukocytes in complete culture medium within 24 hours with subsequent determination of interleukins concentrations (IL-2, IL-4, TNF-alpha in culture medium using enzyme-linked immunosorbent assay, determination of the number of blood cells carrying membrane-bound receptors to IL-2, IL-4, TNF-R1 by flow laser cytometry on cytometer BD FACS Canto tmΙΙ (USA using labeled monoclonal antibody, the standard postoperative histological examination of thyroid gland tissue samples and immunohistochemical detection in samples of thyroid tissue receptors to IL-2, IL-4, TNF-alpha.Results. On the basis of the received results it is possible to allocate 2 clinical-immunologic and morphologic cluster of autoimmune hyperthyroidism syndrome in patients with clinical diagnosis of GD. The first includes the formation of 1 and 2 histological options GD (minimally expressed monocytes infiltration, lack of oncocytic transformation of thyroid epithelium, with some clinical characteristics (persistent and pronounced hyperthyroidism, the large

  3. [Multifaceted body. I. The bodies of medicine].

    Science.gov (United States)

    Saraga, M; Bourquin, C; Wykretowicz, H; Stiefel, F

    2015-02-11

    The human body is the object upon which medicine is acting, but also lived reality, image, symbol, representation and the object of elaboration and theory. All these elements which constitute the body influence the way medicine is treating it. In this series of three articles, we address the human body from various perspectives: medical (1), phenomenological (2), psychosomatic and socio-anthropological (3). This first article discusses four distinct types of representation of the body within medicine, each related to a specific epistemology and shaping a distinct kind of clinical legitimacy: the body-object of anatomy, the body-machine of physiology, the cybernetic body of biology, the statistical body of epidemiology.

  4. Multi-temporal image analysis of historical aerial photographs and recent satellite imagery reveals evolution of water body surface area and polygonal terrain morphology in Kobuk Valley National Park, Alaska

    International Nuclear Information System (INIS)

    Multi-temporal image analysis of very-high-resolution historical aerial and recent satellite imagery of the Ahnewetut Wetlands in Kobuk Valley National Park, Alaska, revealed the nature of thaw lake and polygonal terrain evolution over a 54-year period of record comprising two 27-year intervals (1951–1978, 1978–2005). Using active-contouring-based change detection, high-precision orthorectification and co-registration and the normalized difference index, surface area expansion and contraction of 22 shallow water bodies, ranging in size from 0.09 to 179 ha, and the transition of ice-wedge polygons from a low- to a high-centered morphology were quantified. Total surface area decreased by only 0.4% during the first time interval, but decreased by 5.5% during the second time interval. Twelve water bodies (ten lakes and two ponds) were relatively stable with net surface area decreases of ≤10%, including four lakes that gained area during both time intervals, whereas ten water bodies (five lakes and five ponds) had surface area losses in excess of 10%, including two ponds that drained completely. Polygonal terrain remained relatively stable during the first time interval, but transformation of polygons from low- to high-centered was significant during the second time interval. (letter)

  5. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index

    OpenAIRE

    Pikee Saxena; Anupam Prakash; Aruna Nigam; Archana Mishra

    2012-01-01

    Objective : To determine the proportion of polycystic ovarian syndrome (PCOS) patients who have normal body mass index (BMI) and to compare the clinical, hormonal, and metabolic profile between lean and overweight patients of PCOS. Materials and Methods: One hundred consecutive infertile women with PCOS were studied and divided into lean (BMI between 18.5 and 23) and overweight (BMI ≥ 23). Metabolic and hormonal profile (serum FSH, LH, testosterone, prolactin, TSH on days 2-3 of menstrual cyc...

  6. Whole Body Vibration Exercise Protocol versus a Standard Exercise Protocol after ACL Reconstruction: A Clinical Randomized Controlled Trial with Short Term Follow-Up

    Directory of Open Access Journals (Sweden)

    Gereon Berschin

    2014-09-01

    Full Text Available The suitability and effectiveness of whole body vibration (WBV exercise in rehabilitation after injury of the anterior cruciate ligament (ACL was studied using a specially designed WBV protocol. We wanted to test the hypothesis if WBV leads to superior short term results regarding neuromuscular performance (strength and coordination and would be less time consuming than a current standard muscle strengthening protocol. In this prospective randomized controlled clinical trial, forty patients who tore their ACL and underwent subsequent ligament reconstruction were enrolled. Patients were randomized to the whole body vibration (n=20 or standard rehabilitation exercise protocol (n=20. Both protocols started in the 2nd week after surgery. Isometric and isokinetic strength measurements, clinical assessment, Lysholm score, neuromuscular performance were conducted weeks 2, 5, 8 and 11 after surgery. Time spent for rehabilitation exercise was reduced to less than a half in the WBV group. There were no statistically significant differences in terms of clinical assessment, Lysholm score, isokinetic and isometric strength. The WBV group displayed significant better results in the stability test. In conclusion, preliminary data indicate that our whole body vibration muscle exercise protocol seems to be a good alternative to a standard exercise program in ACL-rehabilitation. Despite of its significant reduced time requirement it is at least equally effective compared to a standard rehabilitation protocol.

  7. [Clinical and morphological features of papillary thyroid cancer in children and adolescents in the Republic of Belarus: analysis of 936 post-Chernobyl carcinomas].

    Science.gov (United States)

    Fridman, M V; Man'kovskaia, S V; Kras'ko, O V; Demidchik, Iu E

    2014-01-01

    There is presented clinical and morphological characteristics of post-Chernobyl papillary thyroid cancer in 936 children and adolescents. In general, carcinoma of these patients featured by locally advanced growth - 57.4% (387 of 674 patients with this sign could be assessed), metastases in regional lymph nodes - 73,7% (N1b in 40.7%) and internal organs - 11.1%. The mean duration of follow-up was 12,4 +/- 3,5 years (range 4.3 to 19.6 years) including children 14,6 +/- 2,7 years (range 8.8 to 19.6 years) and adolescents - 10,1 +/- 3,1 years (range 4.3 to 18.8 years). Overall survival for the 20-year period was 96,6% +/- 1,2%. The causes of death were suicide (7), injuries and accidents (5), secondary malignancies (1), somatic diseases (2). Only in two patients the death was related to the main disease - lung metastases. Free-recurrence survival for the cohort of post-Chernobyl carcinomas was 92,7% +/- 1,0%.

  8. Body-jet水动力吸脂系统在自体脂肪颗粒隆乳术中的应用%Clinical Application of Body-jet Hydrodynamic Liposuction System in Breast Augmentation with Autologous Fat Transplantation

    Institute of Scientific and Technical Information of China (English)

    左宗宝; 孙家明; 郭科; 郭能强

    2014-01-01

    Objective To explore the clinical application and postoperative effects of Body-jet hydrodynamic liposuction system in breast augmentation with autologous fat transplantation. Methods From September 2012 to December 2013, 18 cases received breast augmentation with autologous fat transplantation using Body-jet hydrodynamic liposuction system. The autologous fat was collected and purified by Body-jet hydrodynamic liposuction system, then was injected to each layer of breast tissue multi-levelly and multi-dimensionally. The fat dosage of unilateral breast injection ranged from 100-250 mL. Results After 6 to 12 months' follow-up, all 18 cases achieved good results including full-round contour, natural breast shape and soft feeling of palpation. Satisfactory outcome were received without severe complications. Conclusion Body-jet hydrodynamic liposuction technique is safe, effective, easy to operate, and is an ideal method for breast augmentation with autologous fat transplantation.%目的:探讨Body-jet水动力吸脂系统应用于自体脂肪移植隆乳的方法和效果。方法自2012年9月至2013年12月,我们应用Body-jet水动力吸脂系统行自体脂肪注射隆乳术18例。通过Body-jet水动力辅助吸脂系统,收集纯化过滤自体脂肪颗粒,多隧道多层次均匀注射于乳房各层组织中,单侧乳房一次脂肪注射剂量为100~250 mL。结果本组共18例,术后随访6~12个月,术后乳房较术前明显丰满,形态自然,手感柔软,无严重不良并发症,效果较满意。结论 Body-jet水动力吸脂安全、有效,操作方便,是目前较理想的用于自体脂肪移植的方法。

  9. Body Condition Scores and Evaluation of Feeding Habits of Dogs and Cats at a Low Cost Veterinary Clinic and a General Practice

    Directory of Open Access Journals (Sweden)

    Stephanie A. Sapowicz

    2016-01-01

    Full Text Available This study assessed body condition scores (BCS and feeding habits for dogs and cats. Eighty-six cats and 229 dogs (and their owners were enrolled from 2 clinics: a low cost clinic (n=149 and a general practice (n=166. BCS and body weight were recorded. Owners completed a survey which included animal age, sex, and breed; owner demographics; and feeding practices (e.g., diet, rationale for feeding practices. Owners from the low cost clinic had a significantly lower income (P<0.001 and education (P<0.001 compared to those from the general practice. Animals from the low cost clinic were younger (P<0.001 and dogs were less likely to be neutered (P<0.001. Overweight prevalence was 55% overall (P=0.083, with a significantly higher prevalence in the general practice for cats (44% versus 66%; P=0.046, but not for dogs (58% versus 53%; P=0.230. Multivariate analysis showed that only neuter status was significantly associated with BCS (P=0.004. Veterinarians were the most common source of nutritional information, though lack of accurate nutrition knowledge was common among all participants. These findings support the need for enhanced communication about optimal BCS and nutrition regardless of socioeconomic status.

  10. Body Mass Index, Self-Esteem, and Suicide Risk in Clinically Depressed African American and White American Females.

    Science.gov (United States)

    Palmer, Charles James, Jr.

    2003-01-01

    Assessed whether clinically depressed healthy-weight, overweight, and obese females would differ on self-esteem and suicide risk measures. Data on clinically depressed females from an inpatient psychiatric unit indicated that the three groups did not differ significantly on measures of self-esteem and suicide risk, but depressed, obese, white…

  11. Hypofractionated image-guided breath-hold SABR (Stereotactic Ablative Body Radiotherapy of liver metastases – clinical results

    Directory of Open Access Journals (Sweden)

    Boda-Heggemann Judit

    2012-06-01

    Full Text Available Abstract Purpose Stereotactic Ablative Body Radiotherapy (SABR is a non-invasive therapy option for inoperable liver oligometastases. Outcome and toxicity were retrospectively evaluated in a single-institution patient cohort who had undergone ultrasound-guided breath-hold SABR. Patients and methods 19 patients with liver metastases of various primary tumors consecutively treated with SABR (image-guidance with stereotactic ultrasound in combination with computer-controlled breath-hold were analysed regarding overall-survival (OS, progression-free-survival (PFS, progression pattern, local control (LC, acute and late toxicity. Results PTV (planning target volume-size was 108 ± 109cm3 (median 67.4 cm3. BED2 (Biologically effective dose in 2 Gy fraction was 83.3 ± 26.2 Gy (median 78 Gy. Median follow-up and median OS were 12 months. Actuarial 2-year-OS-rate was 31%. Median PFS was 4 months, actuarial 1-year-PFS-rate was 20%. Site of first progression was predominantly distant. Regression of irradiated lesions was observed in 84% (median time to detection of regression was 2 months. Actuarial 6-month-LC-rate was 92%, 1- and 2-years-LC-rate 57%, respectively. BED2 influenced LC. When a cut-off of BED2 = 78 Gy was used, the higher BED2 values resulted in improved local control with a statistical trend to significance (p = 0.0999. Larger PTV-sizes, inversely correlated with applied dose, resulted in lower local control, also with a trend to significance (p-value = 0.08 when a volume cut-off of 67 cm3 was used. No local relapse was observed at PTV-sizes 3 and BED2 > 78 Gy. No acute clinical toxicity > °2 was observed. Late toxicity was also ≤ °2 with the exception of one gastrointestinal bleeding-episode 1 year post-SABR. A statistically significant elevation in the acute phase was observed for alkaline-phosphatase; in the chronic phase for alkaline-phosphatase, bilirubine, cholinesterase and C

  12. Morphological changes of intestinal mucosa in patients with different clinical variants of irritable bowel syndrome using tetracyclic antidepressants and selective serotonin reuptake inhibitor

    Directory of Open Access Journals (Sweden)

    Nagieva S.

    2015-12-01

    Full Text Available Objective. To assess histological changes of colonic mucosa in patients with clinically different types of irritable bowel syndrome (IBS before and after the treatment with tetracyclic antidepressant and selective serotonin reuptake inhibitor. Methods. Adult patients (over 18 years with confirmed diagnosis of IBS were examined. Biopsy specimens were taken from colon during colonoscopy for the next histological examination. One expert gastrointestinal pathologist assessed all tissue samples. We patent semi quantitative assessment of the severity of cell infiltration of colonic mucosa, which could be assessed as inflammatory (neutrophils, immune (lymphocytes, plasma cells, macrophages, or allergic (eosinophils response (0 to 3 degrees. All patients received treatment due to the clinical variant of IBS: 1 IBS-constipation – mirtazapinum 15 mg/night+lactulose 30ml/morning (+30ml/night if needed; 2 IBS-diarrhea – escitalopram 5mg/night+rifaximine 600mg/twice a day; 3 IBS-unspecified – mirtazapinum 15 mg/escitalopram 5mg/ night; 4 IBS-mixed – mirtazapinum 15 mg, lactulose 30ml/morning (+30ml/night if needed / escitalopram 5mg/night+rifaximine 600mg/twice a day. Results. 107 patients were examined, 36 of them had constipation (I group, 35 – diarrhea (II group, 22- unspecified variant (III group and 12 patients had mixed variant of IBS (IV group due to Rome III criteria (2006. 1st degree of lymphocyte infiltration was detected in 100% IBS-constipation patients and in 58,3% IBS-mixed variant (p0.05. No cases of 2nd or 3rd degree of colonic mucosa infiltration were found. Conclusion. After the treatment with tetracyclic antidepressant and selective serotonin reuptake inhibitor we found that the degree of inflammation of colonic mucosa was reduced or disappeared, due to the zero degree of infiltration according to our patented classification. Citation: Nagieva S, Svintsitskyy A, Kuryk O, Korendovych I. [Morphological changes of intestinal mucosa

  13. 抑郁症合并躯体变形障碍的临床特征%CLINICAL FEATURES OF DEPRESSION WITH BODY DYSMORPHIC DISORDER

    Institute of Scientific and Technical Information of China (English)

    程宇

    2015-01-01

    Objective To study the clinical features of depression with body dysmorphic disorder .Meth‐ods A comparative study on the clinical data of 138 patients who had depression with or without body dysmorphic disorder was conducted .Results Of the 17 patients (12 .32% ) with depression and body dysmor‐phic disorder ,the levels of anxiety ,despair ,psychomotor inhibition ,self‐accusation ,self‐guilty and sui‐cidal behavior were found much higher than those in the patients without body dysmorphic disorder .The attack time in patients with body dysmorphic disorder was earlier than that in patientd without body dys‐morphic disorder ,and the combined treatments were frequently used .There existed no significant differ‐ence in onset time and curative effect between the two groups .Conclusion Body dysmorphic disorder is common in patients with depression ,and measures for preventing suicide in patients with body dysmorphic disorder should be taken .%目的:探讨抑郁症合并躯体变形障碍的临床特征。方法对138例抑郁症患者按照合并躯体变形障碍和不合并躯体变形障碍分为两组,对比分析两组患者的临床资料。结果抑郁症合并躯体变形障碍者17例(12.32%),其焦虑、绝望、精神运动性抑制、自责自罪、自杀行为显著高于不合并躯体障碍者,其发病年龄较早,联合用药较多,而起效时间、疗效与不合并躯体变形障碍者无显著性差异。结论躯体变形障碍在抑郁症中并非少见,对伴有躯体变形障碍的抑郁症患者应谨防自杀行为的发生。

  14. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified ''infarct-like myocarditis''

    International Nuclear Information System (INIS)

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with ''infarct-like myocarditis''. 43 patients with clinically verified cases of ''infarct-like myocarditis'' (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with ''infarct-like myocarditis'' had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with ''infarct-like myocarditis'' were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with ''infarct-like myocarditis'', where we found that LGE alone was the

  15. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified ''infarct-like myocarditis''

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Johannes [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Radiology; Rogg, H.J.; Pauschinger, M.; Fessele, K. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology; Bareiter, T.; Baer, I. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Neuroradiology; Loose, R. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Radiology

    2016-04-15

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with ''infarct-like myocarditis''. 43 patients with clinically verified cases of ''infarct-like myocarditis'' (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with ''infarct-like myocarditis'' had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with ''infarct-like myocarditis'' were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with ''infarct-like myocarditis'', where we found that LGE alone was the

  16. Pleural plaques and lung asbestos bodies in the general population: an autoptical and clinical-radiological survey

    Energy Technology Data Exchange (ETDEWEB)

    Rubino, G.F.; Scansetti, G.; Pira, E.; Piolatto, G.; Mollo, F.; Andrion, A.; Colombo, A.; Bertasso, L.

    1980-01-01

    Of 218 necropsies of male subjects, pleural hyaline plaques were detected in 67 (30%). The prevalence of pleural plaques was found to be related to age at death and to history of previous occupational contact with asbestos. The presence of asbestos bodies in lungs was also associated with pleural plaques; however, the reliability of the presence of ferruginous bodies as an indicator of exposure to asbestos is questioned. The role of environmental exposure will be better demonstrated at the end of an investigation on place of residence, which is still in progress. Chest X-rays showed little sensitivity for use in epidemiological surveys.

  17. Comparison between a linear versus a macrocyclic contrast agent for whole body MR angiography in a clinical routine setting

    OpenAIRE

    Rittig Kilian; Tepe Gunnar; Klumpp Bernhard; Döring Jörg; Bretschneider Christiane; Grimm Florian; Fenchel Michael; Kramer Ulrich; Seeger Achim; Seidensticker Peter R; Claussen Claus D; Miller Stephan

    2008-01-01

    Abstract Background Previous experiences of whole body MR angiography are predominantly available in linear 0.5 M gadolinium-containing contrast agents. The aim of this study was to compare image quality on a four-point scale (range 1–4) and diagnostic accuracy of a 1.0 M macrocyclic contrast agent (gadobutrol, n = 80 patients) with a 0.5 M linear contrast agent (gadopentetate dimeglumine, n = 85 patients) on a 1.5 T whole body MR system. Digital subtraction angiography served as standard of ...

  18. Application of Whole-body Vibration: Technical and clinical studies in healthy persons and people with a neurological disorder

    NARCIS (Netherlands)

    J. Bagheri (Javad)

    2013-01-01

    textabstract__Abstract__ The first use of vibration therapy to improve human fimction and muscle performance dates back to ancient Greece, a time when physicians used saws covered in cotton to transfer vibrations to specific parts of the body to improve muscle performance and relieve pain. However,

  19. The diversity between pancreatic head and body/tail cancers:clinical parameters and in vitro models

    Institute of Scientific and Technical Information of China (English)

    Qi Ling; Xiao Xu

    2013-01-01

    BACKGROUND: Pancreatic  ductal  adenocarcinoma  (PDAC) can be divided into head, body and tail cancers according to the anatomy.  Distinctions  in  tissue  composition,  vascularization and innervations have been clearly identified between the head and body/tail of the pancreas both in embryological development and in histopathology. To understand the postulated genotype difference, we present comprehensive information on two PDAC cell lines as typical representatives originating from pancreatic head and body/tail cancers, respectively. DATA SOURCE: In the present review, we compare the difference between pancreatic head and body/tail cancers regarding clinical parameters and introducing an in vitro model. RESULTS: Increasing  evidence  has  shown  that  tumors  at different locations (head vs body/tail) display different clinical presentation (e.g. incidence, symptom), treatment efficiency (e.g. surgery,  chemotherapy)  and  thus  patient  prognosis.  However, the genetic or molecular diversity (e.g. mutations, microRNA) between  the  two  subtypes  of  PDAC  has  not  been  elucidated so  far.  They  present  different  chemo-  and/or  radio-resistance, extracellular  matrix  adhesion  and  invasiveness,  as  well  as genetic profiles. CONCLUSION: Genetic and tumor biological diversity exists in PDAC according to the tumor localization.

  20. Group morphology

    NARCIS (Netherlands)

    Roerdink, Jos B.T.M.

    2000-01-01

    In its original form, mathematical morphology is a theory of binary image transformations which are invariant under the group of Euclidean translations. This paper surveys and extends constructions of morphological operators which are invariant under a more general group TT, such as the motion group

  1. Intracytoplasmic morphologically selected sperm injection results in improved clinical outcomes in couples with previous ICSI failures or male factor infertility: a meta-analysis.

    Science.gov (United States)

    Setti, Amanda S; Braga, Daniela P A F; Figueira, Rita C S; Iaconelli, Assumpto; Borges, Edson

    2014-12-01

    The objective of this study was to perform the first meta-analysis to compare conventional intracytoplasmic sperm injection (ICSI) outcomes and intracytoplasmic morphologically selected sperm injection (IMSI) outcomes in couples with previous ICSI failures (IF) or male factor infertility (MF). A systematic review was performed by searching Medline database to identify articles reporting on the comparison between ICSI and IMSI outcomes in couples with IF or MF. The main outcome measures were the implantation, pregnancy and miscarriage rates. Thirteen studies fulfilled our predetermined criteria. The overall results of meta-analysis for implantation (OR: 2.88; CI: 2.13-3.89), pregnancy (OR: 2.07; CI: 1.22-3.50) and miscarriage rates (OR: 0.31; CI: 0.14-0.67) were in favor of IMSI in couples with IF. Additionally, the overall result of meta-analysis for implantation (OR: 1.56; CI: 1.11-2.18) and pregnancy rate (OR: 1.61; CI: 1.17-2.23) were in favor of IMSI in couples with MF. IMSI increases the odds of implantation by 50% and pregnancy by 60% in couples with MF. In light of improved clinical outcomes, we recommend promoting the IMSI method in couples with MF. Moreover, IMSI results in a 3-fold increase in implantation rate, a 2-fold increase in pregnancy rate and a 70% decrease in miscarriage rate as compared to ICSI in couples with IF, however, as no randomized evidence exists, randomized studies are needed to confirm the IMSI benefits in couples with IF. PMID:25461360

  2. Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.

    Science.gov (United States)

    Kawakami, Ito; Kobayashi, Zen; Arai, Tetsuaki; Yokota, Osamu; Nonaka, Takashi; Aoki, Naoya; Niizato, Kazuhiro; Oshima, Kenichi; Higashi, Shinji; Katsuse, Omi; Hosokawa, Masato; Hasegawa, Masato; Akiyama, Haruhiko

    2016-04-04

    Choreoathetoid involuntary movements are rarely reported in patients with frontotemporal lobar degeneration (FTLD), suggesting their exclusion as a supportive feature in clinical diagnostic criteria for FTLD. Here, we identified three cases of the behavioral variant of frontotemporal dementia (bvFTD) that display chorea with fused in sarcoma (FUS)-positive inclusions (FTLD-FUS) and the basophilic inclusion body disease (BIBD) subtype. We determined the behavioral and cognitive features in this group that were distinct from other FTLD-FUS cases. We also reviewed the clinical records of 72 FTLD cases, and clarified additional clinical features that are predictive of the BIBD pathology. Symptom onset in the three patients with chorea was at 44.0 years of age (±12.0 years), and occurred in the absence of a family history of dementia. The cases were consistent with a clinical form of FTD known as bvFTD, as well as reduced neurological muscle tone in addition to chorea. The three patients showed no or mild parkinsonism, which by contrast, increased substantially in the other FTLD cases until a later stage of disease. The three patients exhibited severe caudate atrophy, which has previously been reported as a histological feature distinguishing FTLD-FUS from FTLD-tau or FTLD-TAR DNA-binding protein 43. Thus, our findings suggest that the clinical feature of choreoathetosis in bvFTD might be associated with FTLD-FUS, and in particular, with the BIBD subtype.

  3. Lewy Body Dementia Research

    Science.gov (United States)

    ... Research Abstracts Clinical Trials Help end Lewy body dementia now! Donate Research Links Treating Psychosis in Parkinson’s ... The use of antipsychotic medications in Lewy body dementias is a known challenge. Are the medications helpful ...

  4. Clinical application and progress of human body composition measurement methods%人体成分测定方法的临床应用与进展

    Institute of Scientific and Technical Information of China (English)

    闫丹; 阮祥燕

    2011-01-01

    BACKGROUND: Body composition always be partitioned into fat mass and fat-free mass, the qualities and distribution of those two are closely related to the health situation of all human. There is an important relationship between imbalance of body composition and diseases.OBJECTIVE: Overview and contrast the body composition measurement methods. Then give a review about the progress of human body composition measurement methods in clinical application.METHODS: Documents about body composition measurement methods and clinical application were searched from CNKI,PubMed and Elsevier, which published during 1961 to 2010. The progress of human body composition measurement methods in clinical application was summarized.RESULTS AND CONCLUSION: Totally 36 manuscripts were included. The imbalance of body composition is the source of many diseases. The measurement of body composition is related to evaluate the health situation of human. Currently, there are many body composition measurement methods, but each of the methods has its own advantages and defects, at the same time, as more and more new methods are continually appearance.%背景:人体脂肪组织和非脂肪组织的质量及其分布情况与各年龄阶段人群的健康状况密切相关,体成分各组分比例失调是许多疾病发生发展的根源.目的:全面了解目前常用的体成分测量方法,并对各种方法进行对比分析,对体成分的临床应用进展进行概述.方法:电子检索中国期刊全文数据库,PubMed 数据库和Elsevier 数据库1961/2010 收录的体成分测量方法以及临床应用的相关综述和论文报告,并分析其临床应用的研究进展.结果与结论:共纳入体成分测量方法以及临床应用相关文献36 篇.体成分各组分比例失调是许多疾病发生发展的根源,对体成分进行测量关系到对人体健康的评估.目前国际上有许多体成分测量方法,但是由于不同的测量方法都存在着各自

  5. Clinical analysis of 25 cases of intraorbital nonmetallic foreign bodies%眶内非金属异物25例临床分析

    Institute of Scientific and Technical Information of China (English)

    王毅; 李月月; 王巍; 赵海萍; 肖利华

    2011-01-01

    目的 总结眶内非金属异物的临床特征及诊治方法.方法 回顾性系列病例研究.收集2002至2009年经手术证实的眶内非金属异物患者资料25例,总结临床表现、影像学征象、治疗与随访结果.结果 外伤性异物23例,包括:植物性异物11例,玻璃、油脂和石块各3例,塑料笔头2例,爆竹残渣1例.另2例为医源性异物.特征性临床表现为眶周皮肤或结膜瘘道,共11例,发生率为44%,以植物性异物最为多见.CT征象因异物性质不同而各异.植物性异物在外伤早期呈低密度,随时间延长密度逐渐增高,压缩窗宽,异物显示更加清晰.油脂异物表现为与脂肪相近的低密度,石块和玻璃表现为高密度块影.植物性异物在MRI的T1和T2加权像均呈低信号,周围的脓液在T2加权像呈环形高信号影,异物周围的炎性组织强化明显.油脂异物在T1和T2加权像均呈高信号,脂肪抑制显像呈低信号.所有患者均在全身麻醉下接受眶内异物清除术,均经一次手术清除全部异物及周围腐烂组织,感染伤口一期不予缝合.术后半年随访,伤口愈合良好,症状改善,未见与手术相关并发症.结论 眶内非金属异物种类较多,病情复杂各异,处置不当易眶内残留.CT为首选检查方法.正确认识病史及临床表现,运用恰当的手术技巧,彻底清除异物,预后良好.%Objective To evaluate the clinical features,diagnostic methods and treatment of intraorbital nonmetallic foreign body injuries. Methods In a retrospective study,the records of 25 consecutive cases with nonmetallic foreign bodies in the orbit confirmed by surgery were analyzed with special attention to the types of injury,history,clinical manifestations,imaging findings,treatment and follow-up results. Results Among 25 cases with nonmetallic foreign bodies,23 cases were caused by trauma,including 11 cases with wooden bodies,3 cases with glass,grease,or stone,2 cases with plastic pen point

  6. Mathematical morphology

    CERN Document Server

    Najman, Laurent

    2013-01-01

    Mathematical Morphology allows for the analysis and processing of geometrical structures using techniques based on the fields of set theory, lattice theory, topology, and random functions. It is the basis of morphological image processing, and finds applications in fields including digital image processing (DSP), as well as areas for graphs, surface meshes, solids, and other spatial structures. This book presents an up-to-date treatment of mathematical morphology, based on the three pillars that made it an important field of theoretical work and practical application: a solid theoretical foun

  7. Fish Manoeuvres and Morphology

    Science.gov (United States)

    Singh, Kiran; Pedley, Timothy

    2008-11-01

    The extraordinary manoeuvrability observed in many fish is attributed to their inherent flexibility, which might be enhanced by the use of appendages like fins. The aim of this work is to understand the role of morphological adaptations, such as body shape and deployment of median fins, on manoeuvrability and internal body dynamics. The 3d vortex lattice numerical method was employed to analyse the hydrodynamics for arbitrary body planforms of infinitesimal thickness. The internal structure of the body due to the combined skeletal system and soft tissue, is represented as an active Euler-Bernoulli beam, in which the time-dependent bending moment distribution is calculated from body inertia and the hydrodynamic pressure difference across the body. C-turns are the manoeuvre of choice for this work and the response for three different species of fish are examined. Angelfish(Pterophyllum eimekei), pike (Esox sp) and tuna (Thunnus albacares) were chosen for their differences in body profile, median fin use and manoeuvrability. Net direction change and bending moment response to prescribed backbone flexure are calculated and used to interpret the influence of body profile on manoeuvrability and muscle work done. Internal stresses may be computed from anatomical data on muscle fibre distribution and recruitment. To the future, it is intended to extend this work to other typical manoeuvres, such as fast starts for which muscle activation patterns have been measured quite widely.

  8. The link between perception of clinical empathy and nonverbal behavior : The effect of a doctor's gaze and body orientation

    NARCIS (Netherlands)

    Brugel, Sabrina; Postma-Nilsenová, Marie; Tates, Kiek

    2015-01-01

    OBJECTIVES: Clinical empathy is considered to be one of the most important skills for medical professionals. It is primarily conveyed by nonverbal behavior; however, little is known about the importance of different types of cues and their relation to engagement and sincerity as possible correlates

  9. Whole-body MRI screening

    Energy Technology Data Exchange (ETDEWEB)

    Puls, Ralf [HELIOS Klinikum Erfurt (Germany). Inst. of Diagnostic and Interventional Radiology and Neuroradiology; Hosten, Norbert (ed.) [Universitaetsklinikum Greifswald (Germany). Diagnostic Radiology and Neuroradiology

    2014-07-01

    The advent of dedicated whole-body MRI scanners has made it possible to image the human body from head to toe with excellent spatial resolution and with the sensitivity and specificity of conventional MR systems. A comprehensive screening examination by MRI relies on fast image acquisition, and this is now feasible owing to several very recent developments, including multichannel techniques, new surface coil systems, and automatic table movement. The daily analysis of whole-body MRI datasets uncovers many incidental findings, which are discussed by an interdisciplinary advisory board of physicians from all specialties. This book provides a systematic overview of these incidental findings with the aid of approximately 240 high-quality images. The radiologists involved in the project have written chapters on each organ system, presenting a structured compilation of the most common findings, their morphologic appearances on whole-body MRI, and guidance on their clinical management. Chapters on technical and ethical issues are also included. It is hoped that this book will assist other diagnosticians in deciding how to handle the most common incidental findings encountered when performing whole-body MRI.

  10. Whole-body MRI screening

    International Nuclear Information System (INIS)

    The advent of dedicated whole-body MRI scanners has made it possible to image the human body from head to toe with excellent spatial resolution and with the sensitivity and specificity of conventional MR systems. A comprehensive screening examination by MRI relies on fast image acquisition, and this is now feasible owing to several very recent developments, including multichannel techniques, new surface coil systems, and automatic table movement. The daily analysis of whole-body MRI datasets uncovers many incidental findings, which are discussed by an interdisciplinary advisory board of physicians from all specialties. This book provides a systematic overview of these incidental findings with the aid of approximately 240 high-quality images. The radiologists involved in the project have written chapters on each organ system, presenting a structured compilation of the most common findings, their morphologic appearances on whole-body MRI, and guidance on their clinical management. Chapters on technical and ethical issues are also included. It is hoped that this book will assist other diagnosticians in deciding how to handle the most common incidental findings encountered when performing whole-body MRI.

  11. Home and Clinical Cardiovascular Care Center (H4C): a Framework for Integrating Body Sensor Networks and QTRU Cryptography System.

    Science.gov (United States)

    Zakerolhosseini, Ali; Sokouti, Massoud; Pezeshkian, Massoud

    2013-01-01

    Quick responds to heart attack patients before arriving to hospital is a very important factor. In this paper, a combined model of Body Sensor Network and Personal Digital Access using QTRU cipher algorithm in Wifi networks is presented to efficiently overcome these life threatening attacks. The algorithm for optimizing the routing paths between sensor nodes and an algorithm for reducing the power consumption are also applied for achieving the best performance by this model. This system is consumes low power and has encrypting and decrypting processes. It also has an efficient routing path in a fast manner. PMID:24252988

  12. Rehabilitation of anterior cruciate ligament insufficiency in a dancer using the clinical reformer and a balanced body exercise method.

    Science.gov (United States)

    Brown, S E; Clippinger, K

    1996-01-01

    Severe ligamentous knee injuries are uncommon in dance, but partial instability can be disabling. Because of the aesthetics required, use of a brace is not practical. The balanced body approach of exercise and rehabilitation can maximize the physiologic stabilizers of the knee and allow return to dance. While derived from the original principles of Joseph H. Pilates, current practitioners apply modern biomechanical and medical knowledge. The Reformer, a spring loaded exercise device first used by J.H. Pilates, can provide both a simulated environment for dance technique while allowing rest of the injured part and a method of cross training. PMID:24441690

  13. Home and Clinical Cardiovascular Care Center (H4C): a Framework for Integrating Body Sensor Networks and QTRU Cryptography System.

    Science.gov (United States)

    Zakerolhosseini, Ali; Sokouti, Massoud; Pezeshkian, Massoud

    2013-01-01

    Quick responds to heart attack patients before arriving to hospital is a very important factor. In this paper, a combined model of Body Sensor Network and Personal Digital Access using QTRU cipher algorithm in Wifi networks is presented to efficiently overcome these life threatening attacks. The algorithm for optimizing the routing paths between sensor nodes and an algorithm for reducing the power consumption are also applied for achieving the best performance by this model. This system is consumes low power and has encrypting and decrypting processes. It also has an efficient routing path in a fast manner.

  14. 40例儿童呼吸道异物临床分析%Clinical analysis of 40 cases of foreign body in children's airway

    Institute of Scientific and Technical Information of China (English)

    孙黎晓

    2015-01-01

    目的 探讨儿童呼吸道异物的临床特点及其与术前肺部并发症的相关性,为临床治疗提供指导依据.方法 选取40例呼吸道异物患几作为研究对象,根据年龄分为婴儿组、幼儿组、学前组、学龄组;根据异物位置分为甲、乙、丙组;根据异物留存时间,分为Ⅰ、Ⅱ、Ⅲ组.对其临床资料进行回顾性分析,总结其临床特点.结果 幼儿组所占比例最高,显著高于婴儿组、学前组和学龄组患儿,差异均具有统计学意义(P<0.05);植物性异物所占比例最高,显著高于动物性异物、化学合成品异物、金属性异物所占比例(P<0.05);Ⅲ组患者术前的肺部并发症发生率显著高于Ⅰ组和Ⅱ组(P<0.05);丙组术前的肺部并发症发生率显著高于甲组和乙组,差异均具有统计学意义(P<0.05).结论 儿童呼吸道异物并发症发生率与异物类型、异物位置、病程等均有相关性,患几及时就诊有助于预防并发症的发生,植物性异物是导致术前肺部并发症的主要类型,婴幼儿发病以植物性异物居多,学龄期儿童多发生化学合成异物.%Objective To investigate the correlation of foreign body in children' s airway clinical characteristics and preoperative pulmonary complications,and provide guidance for clinical treatment.Methods Forty cases of children with airway foreign body were selected as the research objects.According to the age,all the children were divided into infant group,little children group,pre-school group and school age group.According to the foreign body position were divided into group A,B and C.According to the foreign body retention time,divided into group Ⅰ,Ⅱ and Ⅲ.Retrospective analysised the clinical data and summarize the clinical characteristics.Results Little children group accounts for the proportion to be highest,significantly higher than that of infants group,preschool group and school-age children group,the differences were

  15. The Body as a Site of Gender-Related Distress: Ethical Considerations for Gender Variant Youth in Clinical Settings.

    Science.gov (United States)

    Roen, Katrina

    2016-01-01

    The present article maps out understandings about embodied distress among gender-nonconforming youth. Feminist bioethics and queer-inflected clinical perspectives are used to inform thinking about ethical, nonpathologizing health care in the case of gender-related distress. Specific attention is directed at self-harming among gender variant and trans youth. This is contextualized in relation to the role that self-harm plays for some LGBT youth, where it may be seen as a rite of passage or as reasonable and inevitable way of coping. The particular complexities of self-harm among trans youth seeking clinical intervention are examined. Queer bioethics is proposed as potentially facilitating productive uncertainty with regard to the diverse imagined futures of gender variant and trans youth.

  16. The Body as a Site of Gender-Related Distress: Ethical Considerations for Gender Variant Youth in Clinical Settings.

    Science.gov (United States)

    Roen, Katrina

    2016-01-01

    The present article maps out understandings about embodied distress among gender-nonconforming youth. Feminist bioethics and queer-inflected clinical perspectives are used to inform thinking about ethical, nonpathologizing health care in the case of gender-related distress. Specific attention is directed at self-harming among gender variant and trans youth. This is contextualized in relation to the role that self-harm plays for some LGBT youth, where it may be seen as a rite of passage or as reasonable and inevitable way of coping. The particular complexities of self-harm among trans youth seeking clinical intervention are examined. Queer bioethics is proposed as potentially facilitating productive uncertainty with regard to the diverse imagined futures of gender variant and trans youth. PMID:26644176

  17. Body Image and Body Contouring Procedures.

    Science.gov (United States)

    Sarwer, David B; Polonsky, Heather M

    2016-10-01

    Dissatisfaction with physical appearance and body image is a common psychological phenomena in Western society. Body image dissatisfaction is frequently reported by those who have excess body weight, but also is seen in those of normal body weight. For both groups of individuals, this dissatisfaction impacts self-esteem and quality of life. Furthermore, it is believed to be the motivational catalyst to a range of appearance-enhancing behaviors, including weight loss efforts and physical activity. Body image dissatisfaction is also believed to play a role in the decision to seek the wide range of body contouring procedures offered by aesthetic physicians. Individuals who seek these procedures typically report increased body image dissatisfaction, focus on the feature they wish to alter with treatment, and often experience improvement in body image following treatment. At the same time, extreme body image dissatisfaction is a symptom of a number of recognized psychiatric disorders. These include anorexia nervosa, bulimia nervosa, and body dysmorphic disorder (BDD), all of which can contraindicate aesthetic treatment. This special topic review paper provides an overview of the relationship between body image dissatisfaction and aesthetic procedures designed to improve body contouring. The review specifically focuses on the relationship of body image and body weight, as well as the presentation of body image psychopathology that would contraindicate aesthetic surgery. The overall goal of the paper is to highlight the clinical implications of the existing research and provide suggestions for future research on the psychological aspects of body contouring procedures. PMID:27634782

  18. Body Image and Body Contouring Procedures.

    Science.gov (United States)

    Sarwer, David B; Polonsky, Heather M

    2016-10-01

    Dissatisfaction with physical appearance and body image is a common psychological phenomena in Western society. Body image dissatisfaction is frequently reported by those who have excess body weight, but also is seen in those of normal body weight. For both groups of individuals, this dissatisfaction impacts self-esteem and quality of life. Furthermore, it is believed to be the motivational catalyst to a range of appearance-enhancing behaviors, including weight loss efforts and physical activity. Body image dissatisfaction is also believed to play a role in the decision to seek the wide range of body contouring procedures offered by aesthetic physicians. Individuals who seek these procedures typically report increased body image dissatisfaction, focus on the feature they wish to alter with treatment, and often experience improvement in body image following treatment. At the same time, extreme body image dissatisfaction is a symptom of a number of recognized psychiatric disorders. These include anorexia nervosa, bulimia nervosa, and body dysmorphic disorder (BDD), all of which can contraindicate aesthetic treatment. This special topic review paper provides an overview of the relationship between body image dissatisfaction and aesthetic procedures designed to improve body contouring. The review specifically focuses on the relationship of body image and body weight, as well as the presentation of body image psychopathology that would contraindicate aesthetic surgery. The overall goal of the paper is to highlight the clinical implications of the existing research and provide suggestions for future research on the psychological aspects of body contouring procedures.

  19. Associations between body mass index and molecular subtypes as well as other clinical characteristics of breast cancer in Chinese women

    Directory of Open Access Journals (Sweden)

    Chen FY

    2013-03-01

    Full Text Available Fei-Yu Chen, Hui-Ying Ou, Shou-Man Wang, Yu-Hui Wu, Guo-Jiao Yan, Li-Li Tang Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People's Republic of China Background: Several studies have shown a positive association between body mass index (BMI and the development of hormone receptor-positive breast cancer in postmenopausal women; however, the associations between BMI groups and molecular subtypes have yet to be well defined in premenopausal breast cancer patients. Methods: A total of 2465 female breast cancer patients diagnosed at our institution were recruited for this study. Clinicopathologic information (including age, body height and weight, as well as tumor subtypes and stages was collected; analyses of these characteristics and the associations between them were performed. Results: A total of 1951 cases were included in the study. The mean age was 47.3 years, the majority of patients were of normal weight, premenopausal, had stage 2 cancer, and did not present with positive nodes. The prevalence of the luminal A, luminal B, human epidermal growth factor receptor 2+, and triple-negative subtypes were 57.8%, 11.6%, 6.1%, and 24.5%, respectively. There were significant differences in the clinicopathologic features among BMI groups in premenopausal patients. The case-only odds ratio (OR analysis revealed that normal weight patients tended to have luminal B cancer (OR = 1.4, P = 0.206, and overweight and obese patients tended to have triple-negative cancer in premenopausal patients (OR = 2.8, OR = 3.7, respectively; P < 0.001. Conclusion: In Chinese women, breast cancer came with these characteristics: young mean age (premenopause, luminal A subtype, and the majority of them were within a normal weight range. In premenopausal patients, underweight patients tended to have luminal A, lower human epidermal growth factor receptor 2+ expression, stage 1 and no positive node cancer. However

  20. Symptoms of Lewy Body Dementia

    Science.gov (United States)

    ... Lewy body dementia now! Donate Symptoms Lewy body dementia symptoms and diagnostic criteria Every person with LBD ... an umbrella term for two related clinical diagnoses, dementia with Lewy bodies and Parkinson's disease dementia. The ...

  1. Morfo-histologia do corpo gorduroso perivisceral em adultos de Hedypathes betulinus (Klug, 1825 (Coleoptera, Cerambycidae / Fat body perviceral morphology in adults of Hedypathes betulinus (Klug, 1825 (Coleoptera, Cerambycidae

    Directory of Open Access Journals (Sweden)

    Helio Conte

    2011-12-01

    Full Text Available ResumoNos insetos, o corpo gorduroso pode ser considerado um centro de metabolismo intermediário e também o local de síntese de alguns componentes da hemolinfa. Com objetivo de obter maiores informações sobre essa estrutura, foi realizado um estudo para a sua caracterização morfológica em adultos de Hedypathes betulinus Klug. Os resultados mostram que a estrutura ocorre em duas porções, a primeira, aderida ao trato digestivo e a segunda, associada ao tegumento, denominando-se, corpo gorduroso perivisceral e parietal, respectivamente. Histologicamente o corpo gorduroso apresenta dois tipos celulares, os trofócitos e os enócitos. Os trofócitos apresentam na área citoplasmática, vacúolos, núcleos esféricos, cromatina granular com variações na condensação, e em alguns casos, foram observados núcleos deslocados para a periferia celular. A presença de nucléolos múltiplos em algumas células sugere alta atividade nuclear. Os enócitos foram observados associados aos trofócitos, com núcleos centrais de formato esférico e cromatina de aspecto granular dispersa; os nucléolos apresentaram-se proeminentes em número variável e diferem dos trofócitos pela ausência de vacúolos, citoplasma granular, formato e tamanho das células.AbstractIn insects, the fat body may be considered a center of intermediary metabolism and also the site of synthesis of some components of the hemolymph. Aiming to obtain more knowledge about this structure, a study for characterization of morphological Hedypathes betulinus Klug was carried out. The results show that it takes place in two parts: the first one is adhered to the digestive tract, and the second one, associated with the coat, called the fat body and parietal perivisceral, respectively. Histologically the fat body is composed of two cell types, the trophocytes and the oenocites. The trophocytes present, in its cytoplasmic, vacuoles, spherical nuclei, granular chromatin with variations in

  2. Clinical features and removal strategies of intracranial foreign bodies%颅内异物的临床特点及摘除策略

    Institute of Scientific and Technical Information of China (English)

    张申起; 陈谦学; 陈治标; 郑必全; 田道锋; 蔡强; 彭彬

    2013-01-01

    Objective To investigate clinical features,diagnosis,clearance strategies and prognosis of intracranial foreign bodies.Methods Twenty patients with intracranial foreign bodies were analyzed retrospectively,together with review of the related literatures.Results Twenty patients underwent craniotomy for intracranial foreign body removal under guidance of preoperative CT and X-ray localizations and intraoperative C-arm X-ray machine and ultrasound localizations.A total of 35 foreign bodies were removed.One patient underwent second surgical resection after the incomplete removal due to displacement of intracranial foreign bodies.According to Glasgow outcome score (GOS) at discharge,the outcomes were good (GOS =4-5 points) in 16 patients,poor (GOS =2-3 points) in three and death (GOS =1 point) in one.Conclusions CT and X-ray locations before surgery and C-ann X-ray machine and ultrasound locations in operation avail the removal of foreign bodies by craniotomy.In the meantime,prognosis is satisfactory.%目的 探讨颅内异物的临床特点、诊断、摘除策略及预后. 方法 回顾性分析20例颅内异物患者的临床资料,并结合相关文献进行分析. 结果 20例患者均采用CT及X线片定位联合术中C形臂X线机及超声定位,进行开颅异物取出手术,共取出异物35块,1例因术中异物移位,未能全部摘除,行二次手术摘除.出院时格拉斯哥预后评分(GOS):良好(4~5分)16例,差(2~3分)3例,死亡(1分)1例. 结论 术前采用CT及X线片定位,术中C形臂X线机及超声定位辅助有利于开颅异物取出,患者预后满意.

  3. Interventional management for intra-gastric metallic foreign bodies: clinical analysis of 30 cases%介入法取出胃内金属异物30例

    Institute of Scientific and Technical Information of China (English)

    贺祥; 张和平; 任学群; 靳海英; 张杰; 王长福; 王晓宏; 李长坡; 袁天华

    2013-01-01

    目的 探讨介入治疗胃内金属异物的方法、安全性和疗效.方法 30例胃内金属异物患者,均有经口金属异物吞人史.临床表现有上腹部疼痛不适、纳差、消化不良,精神抑郁,粪便潜血实验阳性.30例患者接受介入治疗,观察患者的医疗费用、手术时间、疗效及并发症.结果 30例患者共32件胃内金属异物经自行制作的圈套器全部安全取出,未出现食管及胃黏膜损伤、出血及其他并发症.结论 介入法取胃内金属异物具有操作简便、创伤小、安全性高、费用低、效果好、并发症少等优点,门诊治疗,不需住院,患者易于接受,是治疗胃内金属异物的理想方法.%Objective To discuss the manipulation, safety and effectiveness of interventional management in treating intra - gastric metallic foreign bodies. Methods A total of 30 patients with intra -gastric metallic foreign bodies were enrolled in this study. All patients were males, aged 22 ~ 54 years with a mean age of 37.8 years. A history of orally-taking metallic foreign body existed in all patients. The clinical manifestations included upper abdominal pain, discomfort, anorexia, indigestion, depression, positive occult blood in stool. Interventional treatment was carried out in all patients. The medical expense, operation time, therapeutic efficacy and complications were recorded, and the results were analyzed. Results A total of 32 pieces of stomach metallic foreign body were successfully removed in 30 patients. Neither injuries of esophageal and gastric mucosa nor bleeding of upper digestive tract occurred. Conclusion Using interven - tional management to remove intra - gastric metallic foreign body has many advantages as this technique is technically - simple, minimally - invasive and highly safe. Besides, this technique carries satisfactory therapeutic effectiveness with less cost and fewer complications. Moreover, the patients need not to stay in hospital, and the

  4. 角膜形态学评价方法及其临床应用的研究进展%Research Advanceson the Morphological Evaluation of Cornea and its Clinical Application

    Institute of Scientific and Technical Information of China (English)

    于荣国

    2013-01-01

    Objective Described in corneal morphology evaluation methods and its clinical application,combined with the advantages and disadvantages of various testing instruments,combined examination,valuation of corneal morphology better.Methods The principle,characteristics of various corneal morphology evaluation instrument and its clinical application are reviewed.Results and Conclusion Valuation and conclusion corneal morphology instruments including keratometer,segment analysis system of corneal topography,Orbscan-II Scheimpflug imaging system and Pentacam anterior and so on,can be more comprehensive valuation of corneal curvature,thickness,irregular,and morphology of aspheric surface.%  目的阐述临床上角膜形态学评价方法及其临床应用进展,结合各种检测仪器的优缺点,进行组合检查,更好地对角膜形态学进行评价。方法本文针对就各种角膜形态学评价仪器的原理、特点及其在临床的应用进行综述。结果与结论角膜形态学评价仪器包括角膜曲率计、角膜地形图、Orbscan-II眼前节分析仪及Pentacam三维眼前节分析系统等,可对角膜曲率、厚度、非规则性、非球面性等形态学进行较为全面的评价。

  5. Clinical effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia: a multicentre randomised controlled trial.

    Science.gov (United States)

    Priebe, Stefan; Savill, Mark; Wykes, Til; Bentall, Richard; Lauber, Christoph; Reininghaus, Ulrich; McCrone, Paul; Mosweu, Iris; Bremner, Stephen; Eldridge, Sandra; Röhricht, Frank

    2016-01-01

    BACKGROUND: The negative symptoms of schizophrenia significantly impact on quality of life and social functioning, and current treatment options are limited. In this study the clinical effectiveness and cost-effectiveness of group body psychotherapy as a treatment for negative symptoms were compared with an active control. DESIGN: A parallel-arm, multisite randomised controlled trial. Randomisation was conducted independently of the research team, using a 1 : 1 computer-generated sequence. Assessors and statisticians were blinded to treatment allocation. Analysis was conducted following the intention-to-treat principle. In the cost-effectiveness analysis, a health and social care perspective was adopted. PARTICIPANTS: ELIGIBILITY CRITERIA: age 18-65 years; diagnosis of schizophrenia with symptoms present at > 6 months; score of ≥ 18 on Positive and Negative Syndrome Scale (PANSS) negative symptoms subscale; no change in medication type in past 6 weeks; willingness to participate; ability to give informed consent; and community outpatient. EXCLUSION CRITERIA: inability to participate in the groups and insufficient command of English. SETTINGS: Participants were recruited from NHS mental health community services in five different Trusts. All groups took place in local community spaces. INTERVENTIONS: Control intervention: a 10-week, 90-minute, 20-session group beginners' Pilates class, run by a qualified Pilates instructor. Treatment intervention: a 10-week, 90-minute, 20-session manualised group body psychotherapy group, run by a qualified dance movement psychotherapist. OUTCOMES: The primary outcome was the PANSS negative symptoms subscale score at end of treatment. Secondary outcomes included measures of psychopathology, functional, social, service use and treatment satisfaction outcomes, both at treatment end and at 6-month follow-up. RESULTS: A total of 275 participants were randomised (140 body psychotherapy group, 135 Pilates group). At the end of

  6. Trends in caesarean section and instrumental deliveries in relation to Body Mass Index: a clinical survey during 1978 - 2001

    Directory of Open Access Journals (Sweden)

    Josefsson Ann

    2010-07-01

    Full Text Available Abstract Background During the last 20 years the rate of CS has increased in Sweden as it has in many other countries. The proportion of pregnant women suffering from a high BMI has also increased rapidly during the same time period. It would therefore be of interest to study both how and if these two observations are related to each other. The aim was therefore to study trends in mode of caesarean section (CS and instrumental deliveries among women in three BMI groups over a time span of almost 25 years with special focus on the observed body weight of pregnant women. Method The design is a retrospective cohort study using medical records of consecutively delivered women at two delivery wards in South East Sweden during the years 1978, 1986, 1992, 1997 and 2001. Results No significant time-trends were found for CS and instrumental delivery within each BMI-group for the time period studied. The proportion of women with BMI ≥ 25 delivered by means of CS or instrumental delivery increased quite dramatically from 1978 to 2001 (χ2 test for trend; p Conclusion Overweight and obese pregnant women constitute a rapidly growing proportion of the total number of CS and instrumental deliveries. Planning and allocation of health resources must be adjusted to this fact and its implications.

  7. Accidental Ingestion of a Foreign Body of Orthodontic Origin - A Review of Risks, Complications and Clinical Recommendations.

    Science.gov (United States)

    Handa, Ashish; Handa, Jasleen Kaur

    2016-01-01

    Ingestion/aspiration episodes of foreign bodies are potential complications in almost all branches of dentistry. Occasionally, orthodontic appliances or small orthodontic components are accidentally swallowed and have caused problems with either the airway or the gastrointestinal tract, especially where the patient is supine or semi-recumbent. Despite their rare occurrence, the morbidity from a single incident and the level of specialized medical care that may be needed on emergency basis to manage such incidents is too high to ignore. Moreover, there is also the related risk of malpractice litigation given the fact that these incidents are preventable and increasing awareness among people. This article attempts to review potential risks and complications of ingestion/aspiration episodes based on relevant literature and describe the type of appliances and their parts most likely to cause problems. Certain recommendations based on best available evidence to minimize the incidence of such events are proposed, and strategies to aid the clinician in the event of such an emergency are also formulated. PMID:27319041

  8. Surgical Protocol and Short-Term Clinical Outcome of Immediate Placement in Molar Extraction Sockets Using a Wide Body Implant

    Directory of Open Access Journals (Sweden)

    Stefan Vandeweghe

    2011-08-01

    Full Text Available Objectives: Implant placement in molar extraction sockets can be difficult due to complex multi-root anatomy and the lack of predictable primary stability. The aim of this study was to evaluate the outcome of an 8 - 9 mm diameter tapered implant, designed to be placed in molar extraction sockets.Material and methods: Patients treated at least 1 year before with a Max® implant (Southern Implants, Irene, South Africa were invited for a clinical examination. Variables collected were surgical and prosthetic protocol, implant dimension and smoking habits. Peri-implant bone level was determined on peri-apical radiographs and compared to baseline, being implant insertion.Results: 98 implants had been placed in 89 patients. One implant had failed. Thirty eight patients representing 47 implants (maxilla 26, mandible 21 were available for clinical examination. Mean bone loss was 0.38 mm (SD 0.48; range - 0.50 – 1.95 after a mean follow-up of 20 months (range 12 - 35. Implant success was 97.9%. Around 30 implants, a bone substitute was used to fill the residual space, but this did not affect the bone loss outcome. Bone loss was only significantly different between maxilla and mandible (0.48 mm vs. 0.27 mm and between the 8 and 9 mm diameter implants (0.23 mm vs. 0.55 mm. A full papilla was present at 71% of the interproximal sites and irrespective of bone loss.Conclusions: The Max® implant demonstrated good primary stability, when placed in molar extraction sockets, with limited bone loss over time.

  9. [Multifaceted body. I. The bodies of medicine].

    Science.gov (United States)

    Saraga, M; Bourquin, C; Wykretowicz, H; Stiefel, F

    2015-02-11

    The human body is the object upon which medicine is acting, but also lived reality, image, symbol, representation and the object of elaboration and theory. All these elements which constitute the body influence the way medicine is treating it. In this series of three articles, we address the human body from various perspectives: medical (1), phenomenological (2), psychosomatic and socio-anthropological (3). This first article discusses four distinct types of representation of the body within medicine, each related to a specific epistemology and shaping a distinct kind of clinical legitimacy: the body-object of anatomy, the body-machine of physiology, the cybernetic body of biology, the statistical body of epidemiology. PMID:25895214

  10. 经皮椎体成形术后再发骨折的临床研究%Clinical Study for New Vertebral Body Fracture After Percutaneous Vertebroplasty

    Institute of Scientific and Technical Information of China (English)

    王智运; 尹庆水; 章凯; 吴文

    2011-01-01

    目的 观察经皮椎体成形术后患者再发椎体骨折的临床特点.探讨其发生机制、疗效及临床意义.方法 回顾分析2004年2月~2009年3月行经皮椎体成形术共342例,其中经诊断并治疗的再发椎体骨折19例.结果 再发椎体压缩性骨折率5.6%.平均年龄70.1岁,男女比例7:12,相邻椎体再发率71.4%,非相邻椎体再发率28.6%,43%再发于术后60 d以内.再次手术后VAS评分显著降低,效果满意.结论 椎体成形术后再发椎体骨折近2/3发生在邻近椎体,再次行椎体成形术可获得较为满意的临床效果.%Objective To investigate the clinical feature of new vertebral body compression fractures afer percutaneous vertebroplasty, including the pathogenesis and curative effect. Methods From February 2004 to March 2009 in our hospital, 342 patients were treated with percutaneous vertebroplasty. A retrospective study showed that new vertebral body compression fractures were found in 19 cases, and all of these cases were retreated with percutaneous vertebroplasty. Results Of 342 patients treated with percutaneous vertebroplasty, 5.6% developed a t oral of 35 new vertebral body fractures. Of the 35 newly documented fractures, average age was 70.1 years old, M-F was 7:12, 71.4% involved vertebrae adjacent to the previously treated vertebral level, 43% of the new fracture occurred within 60 days after treatment of the initial treatment. All of the new fractured vertebral body were retreated with percutaneous vertebroplasty. Conclusion Two-thirds of the re-fractures occur in adjacent vertebral bodies and can be treated with percutaneous vertebroplasty again with satisfied results.

  11. Clinical analysis of 27 cases foreign body in hospital of otorhinolaryngology%耳鼻咽喉医源性异物27例分析

    Institute of Scientific and Technical Information of China (English)

    杨花荣; 刘海楼

    2008-01-01

    目的 探讨耳鼻咽喉医源性异物发生原因及其预防措施.方法 回顾性分析27例耳鼻咽喉医源性异物的临床资料,其中鼻及鼻窦异物13例,耳异物4例,颈部异物3例,食管异物2例,纵隔异物2例,气管异物2例,鼻咽腔异物1例.结果 27例医源性异物除1例纵隔异物及1例颈部金属异物外均顺利取出,其中10例与医务人员发生纠纷,造成不良影响.结论 医源性异物的发生,多与医疗技术操作粗心有关,医者应加强责任心,提高技术水平,杜绝医源性异物的发生.%Objective To discussing the cause and prevention of foreign body in hospital of Otorhinolaryngology.Methods Retrospectively aralyzed the cause and treatment of clinical data of 27 cases foreign body in hospital of Otorhinolaryngology,among which there are 13 csses in nose and nasal sinus,3 cases in cervix,2 in oesophagus,2 in mediastinum,2 in trachea,and 1 case in nose and pharynx antrum.Results Except for one failure of extracting foreign body in mediastinum and one failure of metal body in cervix,other 27 cases are all successful.But there are still 10 disputs between doctors and patients,causing bad influence in hospital.Conclusion To avoid the foreign body in hospital,our medical workers should strengthen our responsibilities,conclude our experience in season,improve our operating skills to prevent such things from happening in our work process.

  12. Quantitative evaluation of correlation of dose and FDG-PET uptake value with clinical chest wall complications in patients with lung cancer treated with stereotactic body radiation therapy.

    Science.gov (United States)

    Algan, O; Confer, M; Algan, S; Matthiesen, C; Herman, T; Ahmad, S; Ali, I

    2015-01-01

    The aim of this study was to investigate quantitatively the dosimetric factors that increase the risk of clinical complications of rib fractures or chest wall pain after stereotactic body radiation therapy (SBRT) to the lung. The correlations of clinical complications with standard-uptake values (SUV) and FDG-PET activity distributions from post-treatment PET-imaging were studied. Mean and maximum doses from treatment plans, FDG-PET activity values on post-SBRT PET scans and the presence of clinical complications were determined in fifteen patients undergoing 16 SBRT treatments for lung cancer. SBRT treatments were delivered in 3 to 5 fractions using 5 to 7 fields to prescription doses in the range from 39.0 to 60.0 Gy. The dose and FDG-PET activity values were extracted from regions of interest in the chest wall that matched anatomically. Quantitative evaluation of the correlation between dose deposition and FDG-PET activity was performed by calculating the Pearson correlation coefficient using pixel-by-pixel analysis of dose and FDG-PET activity maps in selected regions of interest associated with clinical complications. Overall, three of fifteen patients developed rib fractures with chest wall pain, and two patients developed pain symptoms without fracture. The mean dose to the rib cage in patients with fractures was 37.53 Gy compared to 33.35 Gy in patients without fractures. Increased chest wall activity as determined by FDG-uptake was noted in patients who developed rib fractures. Enhanced activity from PET-images correlated strongly with high doses deposited to the chest wall which could be predicted by a linear relationship. The local enhanced activity was associated with the development of clinical complications such as chest wall inflammation and rib fracture. This study demonstrates that rib fractures and chest wall pain can occur after SBRT treatments to the lung and is associated with increased activity on subsequent PET scans. The FDG-PET activity

  13. The stereotactic body radiation therapy: initiation and clinical program; Principe et mise en oeuvre de la radiotherapie en conditions stereotaxiques extracranienne

    Energy Technology Data Exchange (ETDEWEB)

    Gassa, F.; Biston, M.C.; Malet, C.; Lafay, F.; Ayadi, M.; Badel, J.N.; Carrie, C.; Ginestet, C. [Centre de Lutte Contre le Cancer Leon-Berard, Service de Radiotherapie, 69 - Lyon (France)

    2006-11-15

    We fully describe an innovative radiotherapy technique called Stereotactic Body Radiation Therapy (SBRT), and explain how this technique is commonly used for clinical purpose at the anticancer center Leon-Berard (Lyon, France). In this technique, a non-invasive stereotactic body frame is used to locate the tumor site with a great precision. This frame is combined with a system, which enables to track the respiratory motions (Active Breathing Control (ABC) or diaphragmatic compression (DC)) in order to reduce the treatment margins for organ motion due to breathing. Thus, the volume of normal tissues that will be irradiated is considerably reduced. The dosimetry is realized with 3 CT exams performed in treatment conditions. The 3D patient 'repositioning' is done with a volume CT acquisition (kV) combined with orthogonal images (kV and MV). The SBRT requires a system to limit the organ motions. Although the ABC seems to be more fastidious for patient, it would enable to use smaller margins than with DC technique. Nevertheless, the ABC is not compatible with volume CT acquisitions, which considerably improve the patient repositioning. In conclusion, the quality of repositioning and the high level of conformation enable to deliver high equivalent doses (> 100 Gy) in hypo-fractionated mode, without increasing the treatment toxicity. The SBRT employs the last technologic innovations in radio-therapy and is therefore considered as a new efficient tool for solid tumors treatment. (author)

  14. Characterizing adaptive morphological patterns related to habitat use and body mass in Bovidae (Mammalia: Artiodactyla)%牛科(哺乳纲:偶蹄目)动物与生境利用有关的适应形态模式

    Institute of Scientific and Technical Information of China (English)

    Manuel MENDOZA; Paul PALMQVIST

    2006-01-01

    A multivariate analysis of the postcranial skeleton of extant bovids reveals patterns of osteological features indicative of ecological adaptations for habitat use and body size. The morphological patterns that characterize the postcranial anatomy of bovid species from each habitat type were identified with stepwise canonical discriminant analysis and decision trees, a technique based on machine learning. The analyses were carried out using 43 measurements from 110 extant bovid species. The discriminant functions and decision trees obtained allow a perfect discrimination among bovids adapted to open plains, forests and mountainous areas (100 % of correct reclassifications obtained in all comparisons), using sets of variables measured in all major limb bones as well as combinations of variables derived exclusively from single limb elements. Given that the adjusted algorithms involve small sets of postcranial measurements, they can also be applied to noncomplete specimens preserved in archaeological and paleontological assemblages, thus being useful for estimating the locomotor performances of ancient taxa. These algorithms, indicative of ecological adaptations for habitat use, combined with those adjusted with craniodental measurements for estimating the dietary preferences of bovid species, have the potential for characterizing the paleoautecology of extinct taxa and may be used in paleoenvironmental reconstruction. We also analyze if multiple regression equations show higher predictive ability for estimating body mass than simple regression equations, and propose the best algorithms obtained from postcranial morphological variables measured in each single major limb bone [Acta Zoologica Sinica 52 (6): 971-987, 2006].%对广义牛科动物颅后骨骼的多元变量分析揭示了牛科生境利用和体型之间的骨学特征.利用逐步分辨分析方法和一个基于机器学习的决策树方法鉴别了每种生境中牛科动物颅后解剖结构的形态

  15. A Novel Method for Classifying Body Mass Index on the Basis of Speech Signals for Future Clinical Applications: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Bum Ju Lee

    2013-01-01

    Full Text Available Obesity is a serious public health problem because of the risk factors for diseases and psychological problems. The focus of this study is to diagnose the patient BMI (body mass index status without weight and height measurements for the use in future clinical applications. In this paper, we first propose a method for classifying the normal and the overweight using only speech signals. Also, we perform a statistical analysis of the features from speech signals. Based on 1830 subjects, the accuracy and AUC (area under the ROC curve of age- and gender-specific classifications ranged from 60.4 to 73.8% and from 0.628 to 0.738, respectively. We identified several features that were significantly different between normal and overweight subjects (P<0.05. Also, we found compact and discriminatory feature subsets for building models for diagnosing normal or overweight individuals through wrapper-based feature subset selection. Our results showed that predicting BMI status is possible using a combination of speech features, even though significant features are rare and weak in age- and gender-specific groups and that the classification accuracy with feature selection was higher than that without feature selection. Our method has the potential to be used in future clinical applications such as automatic BMI diagnosis in telemedicine or remote healthcare.

  16. El cuerpo como excusa: El diagnostico de la fibromialgia en una consulta de reumatología The body likes excuse: Diagnosing fibromyalgia in a rheumatologic clinic

    Directory of Open Access Journals (Sweden)

    Beatriz Tosal Herrero

    2008-03-01

    Full Text Available Introducción: El proceso de medicalización de la sociedad ha generado una dependencia de la biomedicina para entender, gestionar y legitimar la enfermedad. Como consecuencia surge una nueva forma de considerar los procesos corporales que transforma las identidades y subjetividades de los individuos y los grupos sociales. La enfermedad se concibe y se experimenta en el cuerpo en forma de signos y síntomas. Esta representación de la enfermedad compartida por expertos y enfermos durante el encuentro clínico se convierte en el lenguaje propio de la interacción. Esto ocurre incluso en casos, como el de la fibromialgia, en los que el diagnóstico se produce en ausencia de alteraciones ‘objetivas’ del cuerpo. Metodología: Observación participante, sobre la elaboración y comunicación del diagnóstico de fibromialgia en una consulta de reumatología. Resultados: Se analizan las representaciones sobre el cuerpo y la enfermedad que manejan tanto médicos como enfermos, y la utilización de los síntomas corporales como estrategia de legitimación e interacción durante el encuentro clínico. Conclusión: En la fibromialgia, a pesar de la ausencia de alteraciones biológicas ‘objetivas’, la relación sanitario-paciente se ve mediada por el cuerpo. Este es el lugar en el que se producen las intervenciones terapéuticas y el vehículo de la comunicación entre ambos.Introduction: The process of medicalization of the society has generated a dependence of the biomedicine to understand, to negotiate and to legitimate the illness. As consequence arises, a new form of considering the bodily processes that transforms the identities and the individuals' subjectivities. Persons conceive and experience the illness in the body as signs and symptoms. This representation of the illness shared by experts and patients during the clinical encounter it becomes the characteristic language of the interaction. This even happens in cases, as that of the

  17. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index

    Science.gov (United States)

    Saxena, Pikee; Prakash, Anupam; Nigam, Aruna; Mishra, Archana

    2012-01-01

    Objective: To determine the proportion of polycystic ovarian syndrome (PCOS) patients who have normal body mass index (BMI) and to compare the clinical, hormonal, and metabolic profile between lean and overweight patients of PCOS. Materials and Methods: One hundred consecutive infertile women with PCOS were studied and divided into lean (BMI between 18.5 and 23) and overweight (BMI ≥ 23). Metabolic and hormonal profile (serum FSH, LH, testosterone, prolactin, TSH on days 2–3 of menstrual cycle; serum progesterone premenstrually; serum insulin—fasting and 2 hours postglucose, glucose tolerance test, and fasting serum lipid profile) was performed along with pelvic sonogropahy; and clinical features, viz. waist hip ratio, hirsutism, acne, acanthosis nigricans, and clitoromegaly were recorded. Results: 42% of the PCOS subjects had normal BMI. Average age, hirsutism (80.9% vs. 89.7%), irregular cycles (92.8% vs. 96.6%), acne (9.5% vs. 15.5%), clitoromegaly (2.3% vs. 3.4%), endometrial thickness >4 mm (9.5% vs. 15.5%), and hormonal profile were similar in the lean and overweight PCOS groups. Family history of diabetes (9.5% vs. 24.1%), abnormal glucose tolerance test (GTT) (4.7% vs. 10.3%), deranged lipid profile (14.2% vs. 31%), and 2-hour postprandial insulin levels were higher in the overweight PCOS (P < 0.05). Insulin resistance was observed in 83.3% of lean PCOS but was still lower than 93.1% seen in overweight PCOS (P < 0.05). Conclusion: 42% of the PCOS had normal BMI, but clinical and hormonal profile was similar to PCOS patients with elevated BMI (overweight/obese). However, insulin resistance is observed in 83.3% of lean PCOS. Family history of diabetes, impaired GTT, deranged lipid profile, and insulin resistance were more prevalent in overweight PCOS. PMID:23226650

  18. Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: Feasibility and clinical preliminary results

    International Nuclear Information System (INIS)

    Purpose. To report early clinical experience in stereotactic body radiation therapy (SBRT) delivered using volumetric intensity modulated arc therapy with RapidArc (RA) in patients with primary or metastatic tumours at abdominal sites. Material and methods. Thirty-seven consecutive patients were treated using RA. Of these, 16 had primary or metastatic liver tumours, nine had pancreatic cancer and 12 a nodal metastasis in the retro-peritoneum. Dose prescription varied from 45 to 75 Gy to the Clinical Target Volume in 3 to 6 fractions. The median follow-up was 12 months (6-22). Early local control and toxicity were investigated and reported. Results. Planning objectives on target volumes and organs at risk were met in most cases. Delivery time ranged from 2.8 ± 0.3 to 9.2 ± 2.4 minutes and pre-treatment plan verification resulted in a Gamma Agreement Index from 95.3 ± 3.8 to 98.3 ± 1.7%. At the time of analysis, local control (freedom from progression) at six months, was assessable in 24 of 37 patients and was achieved in 19 patients with a crude rate of 79.2%. Seven patients experienced treatment-related toxicity. Three patients experienced a mild and transient G1 enteritis and two showed a transient G1 liver damage. Two had late toxicity: one developed chronic enteritis causing G1 diarrhoea and G1 abdominal pain and one suffered at three months a G3 gastric bleeding. No patients experienced G4 acute toxicity. Conclusions. SBRT for abdominal targets delivered by means of RA resulted to be feasible with good early clinical results in terms of local control rate and acute toxicity profile. RA allowed to achieve required target coverage as well as to keep within normal tissue dose/volume constraints

  19. Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: Feasibility and clinical preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Scorsetti, Marta; Bignardi, Mario; Alongi, Filippo; Mancosu, Pietro; Navarria, Piera; Castiglioni, Simona; Pentimalli, Sara; Tozzi, Angelo (IRCCS Istituto Clinico Humanitas, Rozzano (Italy)), e-mail: pietro.mancosu@humanitas.it; Fogliata, Antonella; Cozzi, Luca (Oncology Inst. of Southern Switzerland, Bellinzona (Switzerland))

    2011-05-15

    Purpose. To report early clinical experience in stereotactic body radiation therapy (SBRT) delivered using volumetric intensity modulated arc therapy with RapidArc (RA) in patients with primary or metastatic tumours at abdominal sites. Material and methods. Thirty-seven consecutive patients were treated using RA. Of these, 16 had primary or metastatic liver tumours, nine had pancreatic cancer and 12 a nodal metastasis in the retro-peritoneum. Dose prescription varied from 45 to 75 Gy to the Clinical Target Volume in 3 to 6 fractions. The median follow-up was 12 months (6-22). Early local control and toxicity were investigated and reported. Results. Planning objectives on target volumes and organs at risk were met in most cases. Delivery time ranged from 2.8 +- 0.3 to 9.2 +- 2.4 minutes and pre-treatment plan verification resulted in a Gamma Agreement Index from 95.3 +- 3.8 to 98.3 +- 1.7%. At the time of analysis, local control (freedom from progression) at six months, was assessable in 24 of 37 patients and was achieved in 19 patients with a crude rate of 79.2%. Seven patients experienced treatment-related toxicity. Three patients experienced a mild and transient G1 enteritis and two showed a transient G1 liver damage. Two had late toxicity: one developed chronic enteritis causing G1 diarrhoea and G1 abdominal pain and one suffered at three months a G3 gastric bleeding. No patients experienced G4 acute toxicity. Conclusions. SBRT for abdominal targets delivered by means of RA resulted to be feasible with good early clinical results in terms of local control rate and acute toxicity profile. RA allowed to achieve required target coverage as well as to keep within normal tissue dose/volume constraints

  20. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index

    Directory of Open Access Journals (Sweden)

    Pikee Saxena

    2012-01-01

    Full Text Available Objective : To determine the proportion of polycystic ovarian syndrome (PCOS patients who have normal body mass index (BMI and to compare the clinical, hormonal, and metabolic profile between lean and overweight patients of PCOS. Materials and Methods: One hundred consecutive infertile women with PCOS were studied and divided into lean (BMI between 18.5 and 23 and overweight (BMI ≥ 23. Metabolic and hormonal profile (serum FSH, LH, testosterone, prolactin, TSH on days 2-3 of menstrual cycle; serum progesterone premenstrually; serum insulin-fasting and 2 hours postglucose, glucose tolerance test, and fasting serum lipid profile was performed along with pelvic sonogropahy; and clinical features, viz. waist hip ratio, hirsutism, acne, acanthosis nigricans, and clitoromegaly were recorded. Results: 42% of the PCOS subjects had normal BMI. Average age, hirsutism (80.9% vs. 89.7%, irregular cycles (92.8% vs. 96.6%, acne (9.5% vs. 15.5%, clitoromegaly (2.3% vs. 3.4%, endometrial thickness >4 mm (9.5% vs. 15.5%, and hormonal profile were similar in the lean and overweight PCOS groups. Family history of diabetes (9.5% vs. 24.1%, abnormal glucose tolerance test (GTT (4.7% vs. 10.3%, deranged lipid profile (14.2% vs. 31%, and 2-hour postprandial insulin levels were higher in the overweight PCOS (P < 0.05. Insulin resistance was observed in 83.3% of lean PCOS but was still lower than 93.1% seen in overweight PCOS (P < 0.05. Conclusion: 42% of the PCOS had normal BMI, but clinical and hormonal profile was similar to PCOS patients with elevated BMI (overweight/obese. However, insulin resistance is observed in 83.3% of lean PCOS. Family history of diabetes, impaired GTT, deranged lipid profile, and insulin resistance were more prevalent in overweight PCOS.

  1. 中国淡水水体常见束丝藻种类的形态及生理特性研究%MORPHOLOGICAL AND PHYSIOLOGICAL CHARACTERISTICS AND COMMON APHANIZOMENON TYPES IN CHINESE WATER BODIES

    Institute of Scientific and Technical Information of China (English)

    吴忠兴; 曾波; 李仁辉; 宋立荣

    2012-01-01

    our laboratory had shown that three types of Aphanizomenon, A. Flos-aquae, A. Gracile and A. Issatschenkoi, were the most common strains in Chinese freshwater bodies. Due to the limitation of samples and knowledge, however, the physiological characters were not compared in the three-type strains so far. Therefore, in order to further explore their knowledge and investigate the bloom-forming mechanism in Aphanizomenon, in the present study, their morphological and physiological characteristics, including the ratio of length and width in vegetative cell, heterocyst and akinete, growth rate, pigment composition, photosynthetic O2 evolution, and the electron transport rate (ETR), were compared in A. Flos-aquae, A. Gracile and A. Issatschenkoi. The results indicated that some morphological differences were found in the frequency distributions for length/width ratios of vegetative cells, heterocyst, and akinetes. Among them, the most sig nificant difference was found in the akinetes, suggesting that the length/ width ratios of akinetes could be regarded as a taxonomic unit in the genus Aphanizomenon. Moreover, physiological differences were also showed in three types of Aphanizomenon. Compared with the strains of A. Flos-aquae and A. Issatschenkoi, the strains of A. Gracile displayed higher PC contents. However, the strains of A. Gracile showed significantly lower chlorophyll a, carotenoid contents, maximum photosynthesis (Pm), apparent photosynthetic efficiency (a), and maximal electron transport rates (ETRmax) in comparison with the other strains of Aphanizomenon. It suggested that the strain of A. Gracile showed lower competitive abilities in photosynthesis when compared with the strains of A. Flos-aquae and A. Issatschenkoi. In addition, similar physiological features, such as the value of Pm and ETRmax, pigment contents and specific growth rate (μ), were found in A. Flos-aquae and A. Issatschenkoi. These data suggested that the three morphological strains of

  2. 上消化道异物68例临床特点分析%Analysis of Clinical Characteristics of 68 Cases of Upper Gastrointestinal Foreign Bodies

    Institute of Scientific and Technical Information of China (English)

    张帆; 罗志刚; 聂静; 高燕云; 黄敏; 高慧芳

    2013-01-01

      目的探讨上消化道异物的临床特点。方法对2009年9月至2012年8月昆明市第一人民医院进行胃镜下上消化道异物取出的68例患者的临床资料进行回顾性分析。结果68例上消化道异物患者中,男45例66.18%(45/68),女23例33.82%(23/68),平均年龄(42.25±29.42)岁,其中14岁以下占22.51%,14岁到82岁占77.49%;食管异物33.82%(23/68),胃异物55.89%(38/60),十二指肠异物10.29%(7/68)。在所有异物中,碎骨头、铁丝、毒品居前三位,分别占23.53%(16/68),19.12%(13/68),16.18%(11/68)。异物停留时间平均(26.48±12.43)h;64例异物经内镜取出,1例嵌顿于球部,1例下行至空肠,2例手术治疗。结论本地区上消化道异物特点:发病率较高;发病年龄以14岁以下及40岁以上较多;14岁以下异物多为硬币,14岁以上多为食物相关及特殊人群相关异物;异物种类不同,滞留部位不同;大部分异物可经内镜取出,极少患者需外科手术治疗。%  Objective To assess clinical characteristics of Upper gastrointestinal foreign bodies. Methods A retrospective study was conducted in 68 patients with Upper gastrointestinal foreign bodies who were treated under gastroscopein our department from September 2009 to August 2012. Results Among the 68 cases, 45 male cases account for66.18%(45/68) and 23 female cases account for 33.82%(23/68).The average age of the patients was 42.25±29.42. The patients below 14 account for 22.51%;the patients who range in age from 14 to 82 account for77.49%;33.82%(23/68)of the foreign bodies were found in the Esophagus;55.89%(38/60) were found in the stomach10.29%(7/68)were found in theDuodenum.The most frequent foreign bodies were broken bones, Iron wire and drug ,with the percentage being 23.53%(16/68), 19.12%(13/68)and 16.18%(11/68) respectively.The average Residence time of foreign bodies was (26.48±12.43)hours. 64

  3. EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY

    Directory of Open Access Journals (Sweden)

    A. G. Avtandilov

    2015-09-01

    Full Text Available Aim. To study the morphological features of loose fibrous connective tissue (LFCT and myocardial contractility in patients with mitral valve prolapse before and after magnesium orotate course.Material and methods. Patients (n=59 with mitral valve prolapse and the phenotype of undifferentiated connective tissue dysplasia (UCTD were included into the study. A comprehensive morphological analysis of skin biopsy samples was performed to assess morphological and functional changes of LFCT. Standard echocardiography with the assessment of mitral flow was performed in all participants at baseline and after 8 weeks of magnesium orotate intake.Results. According to morphometry increase in proportion of amorphous matrix was found in LFCT sections after 8-week magnesium orotate course compared to baseline (38.6±0.4% and 23.9 ± 0.4%, respectively; p<0.001. According to the echocardiography increase in the end-diastolic (from 4.9±0.04 cm to 5.05±0.03 cm; p<0.05, and the end-sys- tolic (from 2.9±0.04 cm to 3.0±0.03 cm; p<0.01 left ventricular diameters was observed after 8 weeks of treatment as well as improvement of left ventricular diastolic func- tion (E/A raised from 1.42±0.02 to 1.79±0.04; p<0.01.Conclusion. In patients with mitral valve prolapse and UCTD the 8-week magnesium orotate course led to a significant increase in amorphous part of the matrix, improvement of diffusion ability and architectonics of the connective tissue that determines the improvement of flexibility and extensibility.

  4. Clinical implications of the growth-suppressive effects of chlorhexidine at low and high concentrations on human gingival fibroblasts and changes in morphology.

    Science.gov (United States)

    Wyganowska-Swiatkowska, Marzena; Kotwicka, Malgorzata; Urbaniak, Paulina; Nowak, Agnieszka; Skrzypczak-Jankun, Ewa; Jankun, Jerzy

    2016-06-01

    Chlorhexidine (CHX) is considered the gold standard in the antiseptic treatment of the oral cavity, due to its high antibactericidal capability. With the use of CHX mouth-rinse formulations, the bacteriostatic effects are maintained by the adsorption and prolonged release of CHX from oral surfaces. It was believed that antiplaque formation ability and the lack of systemic toxicity of CHX render it an excellent antiseptic in post-surgical dental treatment. However, recent studies have demonstrated that CHX exerts cytotoxic effects on human periodontal tissues, such as gingival fibroblasts and other cells. It also reduces gingival fibroblast adhesion to fibronectin and prevents fibroblast attachment to root surfaces, thus interfering with periodontal regeneration. In this study, using human gingival fibroblasts (HGFs), we investigated effects of CHX on the growth, morphology and proliferation of HGFs. We found that a low concentration (0.002%) of CHX does not interfere with the proliferation and morphology of HGFs. However, a higher concentration (≥0.04%) of CHX inhibits cell proliferation and to a certain extent, affects cell morphology in a time-dependent manner. A decrease in the percentage of cells in the G0/G1 phase and the accumulation of cells in the S phase following treatment with CHX also occurred in a dose-dependent manner. We thus concluded that CHX only at the concentration of 0.002% does not interfere with HGF growth, that is so critical to wound healing. Thus, the application of CHX in the post-surgical antiseptic treatment of the oral cavity should be limited. PMID:27082817

  5. Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma

    Directory of Open Access Journals (Sweden)

    Tang Hanjun

    2011-07-01

    Full Text Available Abstract Purpose To evaluate the clinical efficacy and toxicity of stereotactic body radiation therapy (SBRT using extracranial gamma knife in patients with mainly bulky inoperable early stage non-small cell lung carcinoma (NSCLC. Materials and methods A total of 43 medically inoperable patients with mainly bulky Stage I/II NSCLC received SBRT using gamma knife were reviewed. The fraction dose and the total dose were determined by the radiation oncologist according to patients' general status, tumor location, tumor size and the relationship between tumor and nearby organ at risk (OAR. The total dose of 34~47.5 Gy was prescribed in 4~12 fractions, 3.5~10 Gy per fraction, one fraction per day or every other day. The therapeutic efficacy and toxicity were evaluated. Results The median follow-up was 22 months (range, 3-102 months. The local tumor response rate was 95.35%, with CR 18.60% (8/43 and PR 76.74% (33/43, respectively. The local control rates at 1, 2, 3, 5 years were 77.54%, 53.02%, 39.77%, and 15.46%, respectively, while the 1- and 2-year local control rates were 75% and 60% for tumor ≤3 cm; 84% and 71% for tumor sized 3~5 cm; 55% and 14.6% for tumor sized 5~7 cm; and 45%, 21% in those with tumor size of >7 cm. The overall survival rate at 1, 2, 3, 5 years were 92.04%, 78.04%, 62.76%, 42.61%, respectively. The toxicity of stereotactic radiation therapy was grade 1-2. Clinical stages were significantly important factor in local control of lung tumors (P = 0.000. Both clinical stages (P = 0.015 and chemotherapy (P = 0.042 were significantly important factors in overall survival of lung tumors. Conclusion SBRT is an effective and safe therapy for medically inoperable patients with early stage NSCLC. Clinical stage was the significant prognostic factors for both local tumor control and overall survival. The toxicity is mild. The overall local control for bulky tumors is poor. Tumor size is a poor prognostic factor, and the patients for

  6. Obesidad, morfología corporal y presión arterial en grupos urbanos y rurales de Yucatán Obesity, body morphology, and blood pressure in urban and rural population groups of Yucatan

    Directory of Open Access Journals (Sweden)

    Pedro Arroyo

    2007-08-01

    Full Text Available OBJETIVO: Caracterizar la antropometría y presión arterial de adultos del estado de Yucatán, México. MATERIAL Y MÉTODOS: Se evaluaron diferencias rural-urbanas por grupos sexo-edad en peso, talla, circunferencias de cintura y cadera, y presión arterial en 313 adultos de origen urbano y 271 del rural, de Yucatán. RESULTADOS: No hubo diferencias rural-urbanas en prevalencias de obesidad y sobrepeso, y en hipertensión los urbanos tuvieron valores marginalmente mayores. Se encontró mayor prevalencia rural de cintura anormal sólo en mujeres y hombres jóvenes. La comparación con dos encuestas nacionales y una regional (mixtecos rurales mostró obesidad similar a la notificada en la Encuesta Nacional de Salud 2000 (ENSA y mayor que mixtecos y la informada en la Encuesta Nacional de Enfermedades Crónicas 1993 (ENEC. La prevalencia de cintura anormal fue intermedia entre la indicada en la Encuesta Nacional de Salud y Nutrición 2006 (ENSANUT y mixtecos, y la de hipertensión intermedia entre la notificada en la ENEC y mixtecos. CONCLUSIONES: Las poblaciones maya y mestiza de Yucatán presentaron alta prevalencia de obesidad y cintura anormal que no se acompañaron de prevalencia mayor de hipertensión. Esta observación requiere confirmación.OBJECTIVE: To characterize body morphology and blood pressure of adults of the Mexican state of Yucatan. MATERIAL AND METHODS: Rural-urban differences in weight, height, waist, and hip circumferences, and blood pressure were analyzed in 313 urban and 271 rural subjects. RESULTS: No rural-urban differences in prevalence of obesity and overweight were found. Hypertension was marginally higher in urban subjects. Rural abnormal waist circumference was higher in young men and young women. Comparison with two national surveys and a survey in the aboriginal population (rural mixtecos showed similar prevalence of obesity as ENSA-2000 and higher than mixtecos and ENEC-1993. Abnormal waist circumference was

  7. Metal ion concentrations in body fluids after implantation of hip replacements with metal-on-metal bearing--systematic review of clinical and epidemiological studies.

    Directory of Open Access Journals (Sweden)

    Albrecht Hartmann

    Full Text Available INTRODUCTION: The use of metal-on-metal (MoM total hip arthroplasty (THA increased in the last decades. A release of metal products (i.e. particles, ions, metallo-organic compounds in these implants may cause local and/or systemic adverse reactions. Metal ion concentrations in body fluids are surrogate measures of metal exposure. OBJECTIVE: To systematically summarize and critically appraise published studies concerning metal ion concentrations after MoM THA. METHODS: Systematic review of clinical trials (RCTs and epidemiological studies with assessment of metal ion levels (cobalt, chromium, titanium, nickel, molybdenum in body fluids after implantation of metalliferous hip replacements. Systematic search in PubMed and Embase in January 2012 supplemented by hand search. Standardized abstraction of pre- and postoperative metal ion concentrations stratified by type of bearing (primary explanatory factor, patient characteristics as well as study quality characteristics (secondary explanatory factors. RESULTS: Overall, 104 studies (11 RCTs, 93 epidemiological studies totaling 9.957 patients with measurement of metal ions in body fluids were identified and analyzed. Consistently, median metal ion concentrations were persistently elevated after implantation of MoM-bearings in all investigated mediums (whole blood, serum, plasma, erythrocytes, urine irrespective of patient characteristics and study characteristics. In several studies very high serum cobalt concentrations above 50 µg/L were measured (detection limit typically 0.3 µg/L. Highest metal ion concentrations were observed after treatment with stemmed large-head MoM-implants and hip resurfacing arthroplasty. DISCUSSION: Due to the risk of local and systemic accumulation of metallic products after treatment with MoM-bearing, risk and benefits should be carefully balanced preoperatively. The authors support a proposed "time out" for stemmed large-head MoM-THA and recommend a restricted

  8. Clinical outcomes of video‐assisted thoracic surgery and stereotactic body radiation therapy for early‐stage non‐small cell lung cancer: A meta‐analysis

    Science.gov (United States)

    Ma, Longfei

    2016-01-01

    Background We compared video‐assisted thoracoscopic surgery (VATS) lobectomy and stereotactic body radiation therapy (SABR) to explore clinical outcomes in the treatment of patients with early stage NSCLC. Methods Major medical databases were systematically searched to identify studies on VATS and SBRT published between January 2010 and October 2015. English publications of stage I and II NSCLC with adequate patients and SBRT doses were included. A multivariate random effects model was used to perform meta‐analysis to compare overall survival (OS) and disease‐free survival (DFS) between VATS and SBRT, adjusting for median age and operable patient numbers. Results Thirteen VATS (3436 patients) and 24 SBRT (4433) studies were eligible. The median age and follow‐up duration was 68 years and 42 months for VATS and 74 years and 29.4 months for SBRT patients. After adjusting for the proportion of operable patients and median age, the estimated OS rates at one, two, three, and five years with VATS were 94%, 89%, 84%, and 69% compared with 96%, 94%, 89%, and 82% for SBRT. The estimated DFS rates at one, two, three, and five years with VATS were 97%, 93%, 87%, and 77% compared with 86%, 80%, 73%, and 58% for SBRT. Conclusion Before adjustment, patients treated with SBRT had poorer clinical outcomes compared to those treated with VATS. A substantial difference between median age and operability exists between patients treated with SBRT and VATS. After adjusting for these differences, OS and DFS did not differ significantly between the two techniques. PMID:27385987

  9. Clinical and Dosimetric Predictors of Radiation Pneumonitis in a Large Series of Patients Treated With Stereotactic Body Radiation Therapy to the Lung

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Ryan [University of South Florida School of Medicine, Tampa, Florida (United States); Han Gang [Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida (United States); Sarangkasiri, Siriporn; DeMarco, MaryLou; Turke, Carolyn; Stevens, Craig W. [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States); Dilling, Thomas J., E-mail: Thomas.Dilling@Moffitt.org [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States)

    2013-01-01

    Purpose: To report clinical and dosimetric factors predictive of radiation pneumonitis (RP) in patients receiving lung stereotactic body radiation therapy (SBRT) from a series of 240 patients. Methods and Materials: Of the 297 isocenters treating 263 patients, 240 patients (n=263 isocenters) had evaluable information regarding RP. Age, gender, current smoking status and pack-years, O{sub 2} use, Charlson Comorbidity Index, prior lung radiation therapy (yes/no), dose/fractionation, V{sub 5}, V{sub 13}, V{sub 20}, V{sub prescription}, mean lung dose, planning target volume (PTV), total lung volume, and PTV/lung volume ratio were recorded. Results: Twenty-nine patients (11.0%) developed symptomatic pneumonitis (26 grade 2, 3 grade 3). The mean V{sub 20} was 6.5% (range, 0.4%-20.2%), and the average mean lung dose was 5.03 Gy (0.547-12.2 Gy). In univariable analysis female gender (P=.0257) and Charlson Comorbidity index (P=.0366) were significantly predictive of RP. Among dosimetric parameters, V{sub 5} (P=.0186), V{sub 13} (P=.0438), and V{sub prescription} (where dose = 60 Gy) (P=.0128) were significant. There was only a trend toward significance for V{sub 20} (P=.0610). Planning target volume/normal lung volume ratio was highly significant (P=.0024). In multivariable analysis the clinical factors of female gender, pack-years smoking, and larger gross internal tumor volume and PTV were predictive (P=.0094, .0312, .0364, and .052, respectively), but no dosimetric factors were significant. Conclusions: Rate of symptomatic RP was 11%. Our mean lung dose was <600 cGy in most cases and V20 <10%. In univariable analysis, dosimetric factors were predictive, while tumor size (or tumor/lung volume ratio) played a role in multivariable and univariable and analysis, respectively.

  10. 嗅神经母细胞瘤骨髓转移临床及形态学特征(附1例报告)%The clinical and morphology features of bone marrow metastasis in olfactory neuroblastoma

    Institute of Scientific and Technical Information of China (English)

    梅建刚; 曹红琴; 邵靓婧; 张美娇; 翟勇平; 于亚平

    2012-01-01

    close to the edge, cyloplasmic edge was easy to see the protrusions like prominence shaped; Nucleus was round or oval and hyperchromatic, binucleated and multinucleated tumor cells were visible, nuclear chromalin was finely or coarsely granular evenly dispersed,nucleolus was indistinct or clear and light blue. Bare nuclei were common. Many tumor cells gathered and arranged in radial and annular to form a cell mass, which like rosettes. The tumor cells stained with POX full negative. Conclusion:ONB is a rare neurogenic malignancies, onset occult, when peripheral blood show at least one sery to reduce or can see erythroblasts or immature granulocytesT should consider the possibility of bone marrow metastatic tumors,and timely do bone marrow cyto-morphology examination to confirm the diagnosis and to determine the staging and tumor load,which can provide a reliable basis for clinical treatment and prognosis.

  11. 腰骶移行椎上一节段腰椎的形态学特点及临床意义%Morphological characteristics of the lumbar segment above the lumbosacral transitional vertebrae and its clinic al significance

    Institute of Scientific and Technical Information of China (English)

    杨立辉; 柳伟; 王瑞; 张继宗; 孔晓川; 安立琨; 杜心如

    2011-01-01

    目的 研究腰骶移行椎上一节段腰椎的形态特点,为腰骶移行椎合并腰椎滑脱、不稳症时椎弓根螺钉内固定术提供依据。方法对59例腰骶移行椎上一节段腰椎标本的矢状径、横径,峡部的高度、厚度;椎弓根的纵径、横径;椎板的高度、厚度;脊椎指数及退变情况等进行观测。结果腰骶移行椎上一节段椎体前后径(34.1±2.7)mm,横径(47.5±4.6)mm;峡部高度(12.9±1.6)mm;峡部厚度(9.0±1.2)mm;椎弓根纵径(10.6±2.4)mm,椎弓根横径(14.0±2.4)mm;椎板高度(18.2±2.6)mm,椎板厚度(5.7±1.2)mm。脊椎指数:1∶4.35;81.4%(48例)发生椎体增生,未发现峡部裂。结论腰骶移行椎上一节段腰椎椎体各径线及椎弓根横径较正常L4椎体大,可选择直径稍大的椎弓根螺钉;峡部厚度较正常L4增加;峡部不存在发育薄弱和局部缺损。%Objective To study morphological characteristics of the lumbar segment above the lumbosacral transitional vertebrae, and provide anatomic basis for the clinical treatment in the spondylolisthesis, lumbar disc herniation and pedicle screw fixation. Methods 59 specimens of dry lumbar segment above the lumbosacral transitional vertebrae were anatomically evaluated. The anteroposterior diameter, the transverse diameter, the thickness and height of the vertebral isthmus, the longitudinal diameter and transverse diameter of the vertebral pedicle, the height and thickness of the vertebral lamina, the spine index, and the degeneration state were measured with the caliper and the protractor in all specimens. Results The anteroposterior diameter and transverse diameter of vertebral isthmus were( 34.1 ±2.7 )mm and( 47.5±4.6 )mm respectively. The height of vertebral isthmus was( 12.9±1.6 )mm, and the thickness (9.0±1.2 )mm. The longitudinal and transverse diameters of vertebral pedicle were (10.6±2.4)mm and (14.0±2.4)mm respectively. The height of the lamina was( 18.2±2

  12. 恶性颈动脉体瘤临床治疗及病理分析%Clinical and pathological analysis of malignant carotid body tumor

    Institute of Scientific and Technical Information of China (English)

    张文超; 张仑; 王旭东; 吴延升

    2008-01-01

    目的 探讨恶性颈动脉体瘤的临床特征、病理及预后特点,以及诊断和治疗方法.方法 回顾性总结分析天津医科大学附属肿瘤医院1982年2月至2006年6月50年间收治的9例恶性颈动脉体瘤患者的临床及病理资料.9例均行超声检查,再行数字减影血管造影检查4例,磁共振血管造影检查3例.术前动脉压迫锻炼5例,其余4例肿物较小可触及颈动脉走行者未行压迫锻炼.术式均为动脉体瘤及周围组织扩大切除术,3例阻断颈总动脉,其中1例行人工血管颈动脉重建术,2例结扎颈总动脉.结果 术前诊断"颈动脉体瘤"7例,"转移癌"1例,"颈部肿物待查"1例.8例术后出现颅神经功能障碍,声嘶3例次,舌偏4例次,Horner综合征3例次,口角左偏1例次,呛咳1例次;术中出血50~1800 ml,输血800~1600 ml,无输血并发症;结扎颈动脉者无围手术期死亡及偏瘫等.术后临床及病理诊断恶性颈动脉体瘤9例,有包膜2例,无包膜7例.颈淋巴转移伴肺转移1例.术后放疗2例.随访时间6个月至14年,中位随访时间6年.生存6例,其中伴有间断头晕及呛咳2例;2例死亡,1例死于颈部复发,1例死于肺癌;1例失访.结论 恶性颈动脉体瘤临床少见,常侵犯颈动脉及颅神经,诊断应以病理学特点结合邻近组织侵犯及发生淋巴或远处转移为准;应及早选择手术治疗行广泛切除,发生转移或复发者预后较差,以放疗为主的综合治疗可能有效.%Objective To summarize the clinical, pathological and prognosis character of malignant carotid body tumor and explore its methods of diagnosis and treatment. Methods The data of clinic, pathology, treatment and follow-up of nine patients with malignant carotid body tumor in Tianjin Cancer Hospital from February 1982 to June 2006 were analyzed retrospectively. Results Four Male and five female cases were included ,their average history was 6. 5 years. Shamblin classification: one case was type

  13. Impact of body habitus on quantitative and qualitative image quality in whole-body FDG-PET

    Energy Technology Data Exchange (ETDEWEB)

    Tatsumi, Mitsuaki; Clark, Paul A.; Nakamoto, Yuji; Wahl, Richard L. [Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins Medical Institutions, 601 N. Caroline St., Rm 3223, Baltimore, MD 21287-0817 (United States)

    2003-01-01

    Obtaining consistent high image quality is desirable for clinical positron emission tomography (PET). Body morphology may impact image quality. The purpose of this study was to define the average and the range of body sizes in patients undergoing tumor PET studies in our center and to determine how the body habitus affects the statistical and visual quality of PET images. Height, weight, body surface area (BSA), and body mass index (BMI) were determined in 101 male and 101 female patients (group 1) referred for clinical PET. The summed total counts from three consecutive transaxial slices on non-attenuation-corrected (NAC) 2D fluorine-18 fluorodeoxyglucose (FDG) PET images, which included the largest liver section and no lesions, were determined and compared with body morphology and injected doses (ID) in a representative group of 30 male and 30 female patients (group 2) spanning a range of body morphologies. The visual quality of images was also evaluated using a scoring system by three readers. The average height, weight, and BSA were greater in male than in female patients, but the average BMI was not different between them in group 1. The largest value of weight or BMI was more than four times the smallest value in female patients. The total true counts were best correlated with ID/weight (mCi/kg) in group 2 (r=0.929, P<0.0001). Intermediate to high total counts (930,000 or more) corresponded to ID/weight of 0.22 or higher. The average visual score was positively correlated with the total counts ({rho}=0.63, P<0.0001) and with ID/weight ({rho}=0.68, P<0.0001) on NAC images. The image quality in 22 (84.6%) of 26 patients with intermediate to high total counts was adequate to good, whereas that in 21 (61.8%) of 34 patients with lower total counts was suboptimal. A wide variety of body morphologies was observed in patients referred for clinical FDG-PET tumor studies in our center. The total counts and average image visual score were negatively correlated with

  14. Colite alérgica: características clínicas e morfológicas da mucosa retal em lactentes com enterorragia Allergic colitis: clinical and morphological aspects in infants with rectal bleeding

    Directory of Open Access Journals (Sweden)

    Norys Josefina Diaz

    2002-10-01

    Full Text Available RACIONAL: Recentes estudos indicam a importância do infiltrado eosinofílico na mucosa retal que, juntamente com os dados clínicos, pode servir para estabelecer o diagnóstico de colite alérgica. OBJETIVOS: Descrever, prospectivamente, as características clínicas e a morfologia da mucosa retal em pacientes com enterorragia e suspeita diagnóstica de alergia às proteínas do leite de vaca. MATERIAL E MÉTODOS: Foram estudados 20 pacientes, menores de 6 meses para descrever suas características clínicas e a histologia da mucosa retal que foi comparada com um grupo controle, com suspeita de megacólon congênito. RESULTADOS: A idade média dos pacientes foi 97 ± 47 dias; enterorragia teve início antes dos 120 dias em 85% deles; em vigência de aleitamento materno (40% artificial ou misto (60%. O achado histológico, estatisticamente significativo, foi o infiltrado aumentado de eosinófilos, na mucosa retal, em 18 pacientes. CONCLUSÃO: Pode-se afirmar que esses achados constituem, associados aos dados clínicos, os mais importantes elementos no diagnóstico de colite alérgica, em pacientes menores de 6 meses com enterorragia, que estejam recebendo aleitamento materno e/ou aleitamento artificial.BACKGROUND: Recent studies indicate the importance of eosinophilis infiltrated in the rectal mucous which jointly with the clinical features can serve to establish the diagnostic of allergic colitis. AIM: To describe prospectively, the clinical features and morphological abnormalities of the rectal mucosa in patients with rectal bleeding and clinical diagnosis of cow's milk allergy. METHODS: Clinical features of 20 infants under 6 months of age were described. Morphological findings in rectal mucosa were compared with control group, with suspicion of congenital megacolon. RESULTS: The mean age of the patients was 97 ± 47 days, rectal bleeding started before 120 days in 85% of them; 40% were breastfed, 60% cow's milk formula or both. The most

  15. Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: Clinical implications

    International Nuclear Information System (INIS)

    Purpose: To analyze the patterns of failure, the toxicity profile, and the factors influencing efficacy of stereotactic body radiation (SBRT) for early-stage non-small-cell lung cancer (NSCLC). Methods and materials: A search was based on PubMed electronic databases. All searches were conducted in May, 2009. Results: The local control ranged from 80% to 100% in most studies with adequate isocentric or peripheral biologically effective dose (BED). Recurrences were associated with increased tumor size. The main pattern of failure after SBRT was distant metastasis. Grades 3-5 toxicity occurred mostly in centrally located tumors, and adjuvant chemotherapy may further decrease all recurrences; possibly translating to a survival benefit in large or centrally located tumors where high BED cannot be safely reached. Conclusion: SBRT is an excellent treatment option for early-stage, and mostly medically inoperable, NSCLC. BED at both the isocenter and the tumor periphery is very important for optimal tumor control; higher doses are required for large (≥T2) lesions; SBRT for centrally located tumors can be feasible with a much less aggressive dose regimen than 60-66 Gy/3 fractions and adjacent critical structures excluded from the target volume; chemotherapy may optimize the clinical outcome in large or centrally located lesions.

  16. Food assistance is associated with improved body mass index, food security and attendance at clinic in an HIV program in central Haiti: a prospective observational cohort study

    Directory of Open Access Journals (Sweden)

    Ivers Louise C

    2010-08-01

    Full Text Available Abstract Background Few data are available to guide programmatic solutions to the overlapping problems of undernutrition and HIV infection. We evaluated the impact of food assistance on patient outcomes in a comprehensive HIV program in central Haiti in a prospective observational cohort study. Methods Adults with HIV infection were eligible for monthly food rations if they had any one of: tuberculosis, body mass index (BMI 2, CD4 cell count 3 (in the prior 3 months or severe socio-economic conditions. A total of 600 individuals (300 eligible and 300 ineligible for food assistance were interviewed before rations were distributed, at 6 months and at 12 months. Data collected included demographics, BMI and food insecurity score (range 0 - 20. Results At 6- and 12-month time-points, 488 and 340 subjects were eligible for analysis. Multivariable analysis demonstrated that at 6 months, food security significantly improved in those who received food assistance versus who did not (-3.55 vs -0.16; P Conclusions Food assistance was associated with improved food security, increased BMI, and improved adherence to clinic visits at 6 and 12 months among people living with HIV in Haiti and should be part of routine care where HIV and food insecurity overlap.

  17. Clinical and prognostic significance of bone marrow abnormalities in the appendicular skeleton detected by low-dose whole-body multidetector computed tomography in patients with multiple myeloma

    International Nuclear Information System (INIS)

    Clinical significance of medullary abnormalities in the appendicular skeleton (AS) detected by low-dose whole-body multidetector computed tomography (MDCT) in patients with multiple myeloma (MM) was investigated. A total of 172 patients with monoclonal gammopathy of undetermined significance (MGUS) (n=17), smoldering MM (n=47) and symptomatic MM (n=108) underwent low-dose MDCT. CT values (CTv) of medullary density of AS⩾0 Hounsfield unit (HU) was considered as abnormal. Percentage of medullary abnormalities and the mean CTv of AS in patients with MGUS, smoldering MM and symptomatic MM were 18, 55 and 62% and −44.5 , −20.3 and 11.2 HU, respectively (P<0.001 and P<0.001). Disease progression of MM was independently associated with high CTv on multivariate analysis. In symptomatic MM, the presence of abnormal medullary lesions was associated with increased incidence of high-risk cytogenetic abnormalities (34.4% vs 7.7% P=0.002) and extramedullary disease (10.4% vs 0% P=0.032). It was also an independent poor prognostic predictor (hazard ratio 3.546, P=0.04). This study showed that CTv of AS by MDCT is correlated with disease progression of MM, and the presence of abnormal medullary lesions is a predictor for poor survival

  18. Low incidence of new biochemical and clinical hypogonadism following hypofractionated stereotactic body radiation therapy (SBRT monotherapy for low- to intermediate-risk prostate cancer

    Directory of Open Access Journals (Sweden)

    Pahira John

    2011-03-01

    Full Text Available Abstract Background The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT because of its ability to deliver highly conformal radiation therapy to moving targets. This conformity is achieved via 100s of non-coplanar radiation beams, which could potentially increase transitory testicular irradiation and result in post-therapy hypogonadism. We report on our early experience with CyberKnife SBRT for low- to intermediate-risk prostate cancer patients and assess the rate of inducing biochemical and clinical hypogonadism. Methods Twenty-six patients were treated with hypofractionated SBRT to a dose of 36.25 Gy in 5 fractions. All patients had histologically confirmed low- to intermediate-risk prostate adenocarcinoma (clinical stage ≤ T2b, Gleason score ≤ 7, PSA ≤ 20 ng/ml. PSA and total testosterone levels were obtained pre-treatment, 1 month post-treatment and every 3 months thereafter, for 1 year. Biochemical hypogonadism was defined as a total serum testosterone level below 8 nmol/L. Urinary and gastrointestinal toxicity was assessed using Common Toxicity Criteria v3; quality of life was assessed using the American Urological Association Symptom Score, Sexual Health Inventory for Men and Expanded Prostate Cancer Index Composite questionnaires. Results All 26 patients completed the treatment with a median 15 months (range, 13-19 months follow-up. Median pre-treatment PSA was 5.75 ng/ml (range, 2.3-10.3 ng/ml, and a decrease to a median of 0.7 ng/ml (range, 0.2-1.8 ng/ml was observed by one year post-treatment. The median pre-treatment total serum testosterone level was 13.81 nmol/L (range, 5.55 - 39.87 nmol/L. Post-treatment testosterone levels slowly decreased with the median value at one year follow-up of 10.53 nmol/L, significantly lower than the pre-treatment value (p Conclusions Hypofractionated SBRT offers the radiobiological benefit of a large fraction size and is well-tolerated by

  19. Dosimetric verification and clinical evaluation of a new commercially available Monte Carlo-based dose algorithm for application in stereotactic body radiation therapy (SBRT) treatment planning

    Science.gov (United States)

    Fragoso, Margarida; Wen, Ning; Kumar, Sanath; Liu, Dezhi; Ryu, Samuel; Movsas, Benjamin; Munther, Ajlouni; Chetty, Indrin J.

    2010-08-01

    Modern cancer treatment techniques, such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), have greatly increased the demand for more accurate treatment planning (structure definition, dose calculation, etc) and dose delivery. The ability to use fast and accurate Monte Carlo (MC)-based dose calculations within a commercial treatment planning system (TPS) in the clinical setting is now becoming more of a reality. This study describes the dosimetric verification and initial clinical evaluation of a new commercial MC-based photon beam dose calculation algorithm, within the iPlan v.4.1 TPS (BrainLAB AG, Feldkirchen, Germany). Experimental verification of the MC photon beam model was performed with film and ionization chambers in water phantoms and in heterogeneous solid-water slabs containing bone and lung-equivalent materials for a 6 MV photon beam from a Novalis (BrainLAB) linear accelerator (linac) with a micro-multileaf collimator (m3 MLC). The agreement between calculated and measured dose distributions in the water phantom verification tests was, on average, within 2%/1 mm (high dose/high gradient) and was within ±4%/2 mm in the heterogeneous slab geometries. Example treatment plans in the lung show significant differences between the MC and one-dimensional pencil beam (PB) algorithms within iPlan, especially for small lesions in the lung, where electronic disequilibrium effects are emphasized. Other user-specific features in the iPlan system, such as options to select dose to water or dose to medium, and the mean variance level, have been investigated. Timing results for typical lung treatment plans show the total computation time (including that for processing and I/O) to be less than 10 min for 1-2% mean variance (running on a single PC with 8 Intel Xeon X5355 CPUs, 2.66 GHz). Overall, the iPlan MC algorithm is demonstrated to be an accurate and efficient dose algorithm, incorporating robust tools for MC

  20. 散发性包涵体肌炎临床病理分析%Clinical and pathological features of sporadic inclusion body myositis

    Institute of Scientific and Technical Information of China (English)

    王敏; 笪宇威; 卢岩; 徐敏; 刘璐; 贾建平

    2011-01-01

    Objective To investigate the clinical and pathological features of sporadic inclusion body myositis ( sIBM ) . Methods Clinical manifestations and pathological features of biopsied muscle specimens were summarized and analyzed retrospectively. Muscle specimens were collected from quadriceps femoris and observed by light microscope. Results Both patients developed progressive weakness of quadriceps. Serum creatine kinase levels were mildly. Electromyography showed myogenic changes in one patient and neurogenic changes in another one.cEndomysial inflammation, atrophy of muscle fiber, rimmed vacuoles were found in both patients. Endomysial inflammatory cell infiltrates mostly composed of macrophages and CD8 + cytotoxic/suppressor T lymphocytes. Ubiquitin staining was positive in one patient. Conclusion The clinical and pathological findings of sIBM show that the quadriceps is often involved. The histological examination plays an important role in the diagnosis of sIBM.%目的 探讨散发性包涵体肌炎(sIBM)患者的临床及病理特点.方法 收集2例于2008年至2010年就诊并明确诊断为s1BM的患者临床、病理资料.两例患者均有股四头肌无力和萎缩,1例出现肢体远端无力和上肢无力.2例患者均进行了肌肉活体组织检查标本的组织学、酶组织化学染色和免疫组织化学染色.结果 2例患者肌酶均轻度升高.肌电图检查示1例呈肌源性损害,1例呈神经源性损害.2例患者的骨骼肌主要病理改变都是肌内衣炎细胞浸润、肌纤维萎缩,肌纤维内嗜碱性镶边空泡.免疫组织化学染色提示CD8+淋巴细胞浸润为主,1例患者镶边空泡肌纤维内Ubiquitin 染色阳性.结论 本文2例sIBM以股四头肌损害明显,病情缓慢进展,依靠肌肉活检确定诊断.

  1. Following the Rules Set by Accreditation Agencies and Governing Bodies to Maintain In-Compliance Status: Applying Critical Thinking Skills When Evaluating the Need for Change in the Clinical Laboratory.

    Science.gov (United States)

    Byrne, Karen M; Levy, Kimberly Y; Reese, Erika M

    2016-05-01

    Maintaining an in-compliance clinical laboratory takes continuous awareness and review of standards, regulations, and best practices. A strong quality assurance program and well informed leaders who maintain professional networks can aid in this necessary task. This article will discuss a process that laboratories can follow to interpret, understand, and comply with the rules and standards set by laboratory accreditation bodies. PMID:26945880

  2. Following the Rules Set by Accreditation Agencies and Governing Bodies to Maintain In-Compliance Status: Applying Critical Thinking Skills When Evaluating the Need for Change in the Clinical Laboratory.

    Science.gov (United States)

    Byrne, Karen M; Levy, Kimberly Y; Reese, Erika M

    2016-05-01

    Maintaining an in-compliance clinical laboratory takes continuous awareness and review of standards, regulations, and best practices. A strong quality assurance program and well informed leaders who maintain professional networks can aid in this necessary task. This article will discuss a process that laboratories can follow to interpret, understand, and comply with the rules and standards set by laboratory accreditation bodies.

  3. Prosodic Morphology in Four Chinese Dialects.

    Science.gov (United States)

    Yip, Moira

    1992-01-01

    Yanggu, Anxiang, and Yuanyang diminutives and Cantonese familiar name formation are examined in the light of recent understanding about the role of prosodic categories in phonology and morphology. The results lend strong support to the growing body of research in prosodic morphology, especially the pioneering work of McCarthy and Prince. (52…

  4. Morphological changes of intestinal mucosa in patients with different clinical variants of irritable bowel syndrome using tetracyclic antidepressants and selective serotonin reuptake inhibitor

    OpenAIRE

    Nagieva S.; Svintsitskyy A.; Kuryk O.; Korendovych I.

    2015-01-01

    Objective. To assess histological changes of colonic mucosa in patients with clinically different types of irritable bowel syndrome (IBS) before and after the treatment with tetracyclic antidepressant and selective serotonin reuptake inhibitor. Methods. Adult patients (over 18 years) with confirmed diagnosis of IBS were examined. Biopsy specimens were taken from colon during colonoscopy for the next histological examination. One expert gastrointestinal pathologist assessed all tissue samples....

  5. Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology

    Science.gov (United States)

    Zhu, Yizheng; Terry, Neil G.; Woosley, John T.; Shaheen, Nicholas J.; Wax, Adam

    2011-01-01

    We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nuclei for assessing the health of epithelial tissues. Clinical application is enabled by an endoscopic fiber-optic probe that employs a 2.3-m-long coherent fiber bundle and is compatible with the standard 2.8-mm-diam biopsy channel of a gastroscope. The probe allows for real-time data acquisition by collecting the scattering from multiple angles in parallel, enabled by the Fourier domain approach. The performance of the probe is characterized through measurement of critical parameters. The depth-resolved sizing capability of the system is demonstrated using single- and double-layer microsphere phantoms with subwavelength sizing precision and accuracy achieved. Initial results from a clinical feasibility test are also presented to show in vivo application in the human esophagus.

  6. Genomic and clinical effects associated with a relaxation response mind-body intervention in patients with irritable bowel syndrome and inflammatory bowel disease.

    Directory of Open Access Journals (Sweden)

    Braden Kuo

    Full Text Available Irritable Bowel Syndrome (IBS and Inflammatory Bowel Disease (IBD can profoundly affect quality of life and are influenced by stress and resiliency. The impact of mind-body interventions (MBIs on IBS and IBD patients has not previously been examined.Nineteen IBS and 29 IBD patients were enrolled in a 9-week relaxation response based mind-body group intervention (RR-MBI, focusing on elicitation of the RR and cognitive skill building. Symptom questionnaires and inflammatory markers were assessed pre- and post-intervention, and at short-term follow-up. Peripheral blood transcriptome analysis was performed to identify genomic correlates of the RR-MBI.Pain Catastrophizing Scale scores improved significantly post-intervention for IBD and at short-term follow-up for IBS and IBD. Trait Anxiety scores, IBS Quality of Life, IBS Symptom Severity Index, and IBD Questionnaire scores improved significantly post-intervention and at short-term follow-up for IBS and IBD, respectively. RR-MBI altered expression of more genes in IBD (1059 genes than in IBS (119 genes. In IBD, reduced expression of RR-MBI response genes was most significantly linked to inflammatory response, cell growth, proliferation, and oxidative stress-related pathways. In IBS, cell cycle regulation and DNA damage related gene sets were significantly upregulated after RR-MBI. Interactive network analysis of RR-affected pathways identified TNF, AKT and NF-κB as top focus molecules in IBS, while in IBD kinases (e.g. MAPK, P38 MAPK, inflammation (e.g. VEGF-C, NF-κB and cell cycle and proliferation (e.g. UBC, APP related genes emerged as top focus molecules.In this uncontrolled pilot study, participation in an RR-MBI was associated with improvements in disease-specific measures, trait anxiety, and pain catastrophizing in IBS and IBD patients. Moreover, observed gene expression changes suggest that NF-κB is a target focus molecule in both IBS and IBD-and that its regulation may contribute to

  7. EFFECTS OF LONG-TERM ROUX-EN-Y GASTRIC BYPASS ON BODY WEIGHT AND CLINICAL METABOLIC COMORBIDITIES IN BARIATRIC SURGERY SERVICE OF A UNIVERSITY HOSPITAL

    Science.gov (United States)

    da SILVA, Cátia Ferreira; COHEN, Larissa; SARMENTO, Luciana d'Abreu; ROSA, Felipe Monnerat Marino; ROSADO, Eliane Lopes; CARNEIRO, João Régis Ivar; de SOUZA, Antônio Augusto Peixoto; MAGNO, Fernanda Cristina Carvalho Mattos

    2016-01-01

    ABSTRACT Background: Due to the high failure rate observed in the clinical treatment of morbid obesity an increase in bariatric surgery indications, as an alternative for the control of obesity and comorbidities, is noticeable. Aim: To evaluate the performance of type 2 diabetes mellitus, high blood pressure and dyslipidemia in patients submitted to Roux-en-Y gastric bypass in late follow-up. Methods: Retrospective analysis of 59 patients included in the bariatric surgery program. Anthropometric (height and body weight) and laboratory (LDLc, HDLc, VLDLc, triglyceride -TG - and glucose) data were collected on pre- and postoperative stages, through medical records. Results: Among the patients, 86% were female aged 43±11, of whom 52% had attended high school. The average postoperative time was 7±3 years. During the postoperative period, there were decreases of weight and body mass index, respectively (133±06 kg vs 91±04 kg p<0.05 e 49±74 kg/m2 vs 33±79 kg/m2, p<0.05). In comparison to the preoperative stage, lower concentrations of glucose (101.00±26.99 vs 89,11±15.19, p=0.014), total cholesterol rates (179.00±37,95 vs 167.48±28,50, p=0.016), LDLc (104.30±33.12 vs 91.46±24.58, p=0.016), VLDLc (25.40±11,12 vs 15.68±7.40, p<0.01), and TG (143.35±86.35 vs 82.45±37.39, p<0.01) and higher concentrations of HDLc (43.53±8.23 vs 57.90±15.60, p<0.01) were identified in the postoperative stage. 40% of hypertensive patients were still undergoing high blood pressure treatment during the postoperative stage. There was remission of type 2 diabetes mellitus and dyslipidemia on 81% and 94% of the cases, respectively. Conclusion: Roux-en-Y gastric bypass has proven itself to be an effective long term procedure, promoting weight loss, remission of DM2 and dyslipidemia. PMID:27683769

  8. Unusual Morphological Alteration in Sigmoid Notch: An Insight Through CBCT.

    Science.gov (United States)

    Gupta, Anjali; Kant, Sanchita; Phulambrikar, Tushar; Kode, Manasi; Singh, Siddharth Kumar

    2015-12-01

    The Temporomandibular Joint (TMJ) is a ginglymo-diarthrodial joint known to be the most complex joint in human body. Growth disturbances, owing to genetic influences or trauma during the intrauterine life or during early developmental age may lead to morphological and functional variations in the mandible resulting in developmental anomaly. We report a rare case of altered sigmoid notch morphology on the right side and condylar hypoplasia on the left side, not related to any clear pathological disorder. Cone Beam Computed Tomography (CBCT) was helpful in evaluating this case. This case of unknown aetiology was thoroughly examined; based on clinical and radiographic findings, we suggest that this case is of congenital origin. PMID:26816996

  9. Morphology of Andrias davidianus iridovirus and characterization of its inclusion bodies%大鲵虹彩病毒的形态结构及其包涵体特征

    Institute of Scientific and Technical Information of China (English)

    周小愿; 张星朗; 吉红; 韩亚慧; 贾秋红; 高宏伟

    2015-01-01

    Electron microscope and immunofluorescence microscope were used to observe and study the purified Chinese giant salamanders iridovirus (CGSIV) viral particles and infected EPC cells with CGSIV and visceral tissue samples of sick Chinese giant salamanders.The negatively stained electron micrographs revealed that CGSIV was ball -shape with envelops and about 150 nm in diameter.The electron micrographs of ultra -thin section of infected cells suggested that CGSIV virions showed typically morphological character of iridovirus , which possessed icosahedral symmetry with member envelopes , and CGSIV was composed of the capsid and nucleoid .Its capsid was regular hexagon in shape and (150 ±5) nm(N =30) in diameter, and the thickness of capsid was about 5 nm and the nucleoid was (98 ±18) nm (N =27) in diameter.CGSIV virions were found in lung and kidney of sick Chinese giant salamanders and possessed the similar ultrastructure as that ob -served in electron micrographs of ultra -thin section of infected cells.A large number of red fluorescent signals were detec -ted in CGSIV -infected cells by immunofluorescence assay , which were distributed as patches in cytoplasm .Based on the observation of ultra -thin section of infected EPC cells and fluorescence microscopy images , it was believed that different types of CGSIV inclusion bodies could be found in cytoplasm of the infected cells .%运用电镜和免疫荧光技术,对纯化的大鲵(Andrias davidianus)虹彩病毒粒子、感染病毒的 EPC 细胞以及确诊感染病毒的病鲵组织样品进行观察和分析。结果表明,纯化的大鲵虹彩病毒负染后电镜下显示球形结构,具囊膜,直径约150 nm;感染 EPC 细胞中的病毒颗粒呈典型的正二十面体结构,由核衣壳和核心构成,核衣壳呈正六边形,对角直径为(150±5) nm (N =30),核衣壳厚度约5 nm,核心直径为(98±18) nm (N =27)。在病鲵病变的肺和肾组织中发现

  10. Initial Clinical Experience in Multiple Myeloma Staging by Means of Whole-Body Resonance Techniques; Experiencia clinical inicial en la estadificacion del mieloma multiple mediante tecnicas de resonancia de todo el cuerpo

    Energy Technology Data Exchange (ETDEWEB)

    Gallego, J. I.; Concepcion, L.; Alonso, S.; Sanchez, B.; Manzi, F. [Hospital General Universitario de Alicante. Alicante (Spain)

    2003-07-01

    To develop a magnetic resonance (MR) exploratory technique equivalent to serial bone X-ray, and to compare their precision in the staging of multiple myeloma (MM) patients. Multiple acquisition T1-weights TSE and STIR sequences in the coronal plane were performed. Ten healthy volunteers and 11 multiple myeloma diagnosed patients were included. The visualization of bony structures was particularly noted,with special attention given to those which would normally be included in a serial bone X-ray. In the case of the patients, a comparison was made between diagnostic capacities of the MR sequences. MR highlighters significantly more (p<0.05) bony elements than did the serial bone X-ray. This was greatly due to a sequential displacement of the scanner bed, allowing for field-of-views which were minimally from head to third proximal of the leg. Magnetic resonance detected a significantly higher number (p<0.05) of lesions. It was, in turn, capable of revealing greater lesion extensions, even to the point of implying staging classification changes in 18% of the patients. The utilization of whole-body MR techniques in multiple myeloma patients is feasible and clinically beneficial. MR is both more sensitive and more specific than serial bone X-ray for evaluation of bony lesions in MM. It is currently serving as a valid alternative in a growing numbers of patients. (Author) 10 refs.

  11. A Combination of Gestalt Therapy, Rosen Body Work, and Cranio Sacral Therapy did not help in Chronic Whiplash-Associated Disorders (WAD - Results of a Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt

    2004-01-01

    Full Text Available The chronic state of whiplash-associated disorder (WAD might be understood as a somatization of existential pain. Intervention aimed to improve quality of life (QOL seemed to be a solution for such situations. The basic idea behind the intervention was holistic, restoring quality of life and relationship with self, in order to diminish tension in the locomotion system, especially the neck. A psychosomatic theory for WAD is proposed. Our treatment was a short 2-day course with teachings in philosophy of life, followed by 6 to 10 individual sessions in gestalt psychotherapy and body therapy (Rosen therapy and Cranio Sacral therapy, followed by a 1-day course approximately 2 months later, closing the intervention. Two independent institutions did the intervention and the assessments. In a randomized, clinically controlled setting, 87 chronic WAD patients were included with a median duration of 37 months from their whiplash accidents. One patient never started. Forty-three had the above intervention (female/male = 36/7, ages 22–49, median 37 years and another 43 were assigned to a nontreated control group (female/male = 35/8, ages 1848, median 38. Six had disability pension and 27 had pending medicolegal issues in each group. Effect variables were pain in neck, arm, and/or head; measures of quality of life and daily activities; as well as general physical or mental health. Wilcoxon test for between-groups comparisons with intention-to-treat analyses was conducted; the square curve paradigm testing for immediate improvements of health and quality of life was also used. The groups were comparable at baseline. From the intervention group, 11 dropped out during the intervention (4 of those later joined the follow-up investigation, 22 of the remaining 32 graduated the course, and 35 of the 43 controls did as well. Approximately 3 months later, we found no clinically relevant or significant increase in any effect measure. The above version of a quality

  12. Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

    Science.gov (United States)

    Ferrer-Garcia, Marta; Gutierrez-Maldonado, Jose; Treasure, Janet; Vilalta-Abella, Ferran

    2015-09-01

    Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations. PMID:26095041

  13. A Pilot Clinical Trial to Objectively Assess the Efficacy of Electroacupuncture on Gait in Patients with Parkinson's Disease Using Body Worn Sensors.

    Directory of Open Access Journals (Sweden)

    Hong Lei

    Full Text Available Gait disorder, a key contributor to fall and poor quality of life, represents a major therapeutic challenge in Parkinson's disease (PD. The efficacy of acupuncture for PD remains unclear, largely due to methodological flaws and lack of studies using objective outcome measures.To objectively assess the efficacy of electroacupuncture (EA for gait disorders using body-worn sensor technology in patients with PD.In this randomized pilot study, both the patients and assessors were masked. Fifteen PD patients were randomly assigned to an experimental group (n = 10 or to a control group (n = 5. Outcomes were assessed at baseline and after completion of three weekly EA treatments. Measurements included gait analysis during single-task habitual walking (STHW, dual-task habitual walking (DTHW, single-task fast walking (STFW, dual-task fast walking (DTFW. In addition, Unified Parkinson's Disease Rating Scale (UPDRS, SF-12 health survey, short Falls Efficacy Scale-International (FES-I, and visual analog scale (VAS for pain were utilized.All gait parameters were improved in the experimental group in response to EA treatment. After adjustment by age and BMI, the improvement achieved statistical significant level for gait speed under STHW, STFW, and DTFW (9%-19%, p0.110. The highest correlation between gait parameters and UPRDS scores at baseline was observed between gait speed during STFW and UPDRS II (r = -0.888, p = 0.004. The change in this gait parameter in response to active intervention was positively correlated with baseline UPDRS (r = 0.595, p = 0.057. Finally, comparison of responses to treatment between groups showed significant improvement, prominently in gait speed (effect size 0.32-1.16, p = 0.001.This study provides the objective proof of concept for potential benefits of non-pharmaceutical based EA therapy on enhancing gait in patients with PD.ClinicalTrials.gov NCT02556164.

  14. Craving for Food in Virtual Reality Scenarios in Non-Clinical Sample: Analysis of its Relationship with Body Mass Index and Eating Disorder Symptoms.

    Science.gov (United States)

    Ferrer-Garcia, Marta; Gutierrez-Maldonado, Jose; Treasure, Janet; Vilalta-Abella, Ferran

    2015-09-01

    Virtual reality (VR) technology has been successfully used to study the influence of specific and contextual food-related cues on emotional, cognitive and behavioural responses in patients with eating disorders (ED) and healthy controls. Following this research line, the present study assesses the effect on reported food craving of the type of food (low calorie versus high calorie) and the presence or absence of other people (private versus social context) in VR environments. Relationships between craving and body mass index (BMI) and ED symptoms are also explored. Eighty-seven female students were exposed to four VR scenarios presented in random order: a low-calorie kitchen, a high-calorie kitchen, a low-calorie restaurant and a high-calorie restaurant. After 2 minutes of exposure to each virtual scenario, food craving was assessed. Repeated measures analyses of covariance were conducted to assess changes in food craving following exposure to the different VR environments. Time elapsed since the last meal was introduced as a covariate to control for responses produced by food deprivation. Correlation and hierarchical multiple regression analyses were also conducted to assess the relationship between reported food craving and BMI and ED symptoms. Participants experienced higher levels of food craving after exposure to high-calorie foods (in both the kitchen and restaurant environments) than after exposure to low-calorie foods. Being alone in the kitchen or with friends in the restaurant had no effect on reported craving. Overall, neither BMI nor ED symptoms were related with reported food craving; only in the restaurant with low-calorie food was a significant negative correlation found between BMI and food craving. The results suggest that cue exposure in virtual environments is an effective procedure for inducing food craving in healthy controls and may be useful as a research and therapeutic tool in clinical populations.

  15. Urethrogram-directed Stereotactic Body Radiation Therapy (SBRT for Clinically Localized Prostate Cancer in Patients with Contraindications to Magnetic Resonance Imaging

    Directory of Open Access Journals (Sweden)

    Ima ePaydar

    2015-09-01

    Full Text Available Purpose: Magnetic resonance imaging (MRI-directed stereotactic body radiation therapy (SBRT has been established as a safe and effective treatment for prostate cancer. For patients with contraindications to MRI, CT-urethrogram is an alternative imaging approach to identify the location of the prostatic apex to guide treatment. This study sought to evaluate the safety of urethrogram-directed SBRT for prostate cancer.Methods: Between February 2009 and January 2014, 31 men with clinically localized prostate cancer were treated definitively with urethrogram-directed SBRT with or without supplemental intensity modulated radiation therapy (IMRT at Georgetown University Hospital. SBRT was delivered either as a primary treatment of 35-36.25 Gray (Gy in 5 fractions or as a boost of 19.5 Gy in 3 fractions followed by supplemental conventionally fractionated intensity modulated radiation therapy (45-50.4 Gy. Toxicities were recorded and scored using the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v.4.0.Results: The median patient age was 70 years with a median prostate volume of 38 cc. The median follow-up was 3.7 years. The patients were elderly (Median age = 70, and comorbidities were common (Carlson Comorbidity Index > 2 in 36%. 71% of patients utilized alpha agonists prior to treatment, and 9.7% had prior procedures for benign prostatic hyperplasia (BPH. The 3-year actuarial incidence rates of > Grade 3 GU toxicity and > Grade 2 GI toxicity were 3.2% and 9.7%, respectively. There were no Grade 4 or 5 toxicities.Conclusions: MRI is the preferred imaging modality to guide prostate SBRT treatment. However, urethrogram-directed SBRT is a safe alternative for the treatment of patients with prostate cancer who are unable to undergo MRI.

  16. Clinical outcome of stereotactic body radiotherapy for primary and oligometastatic lung tumors: a single institutional study with almost uniform dose with different five treatment schedules

    International Nuclear Information System (INIS)

    To evaluate clinical outcomes of stereotactic body radiotherapy (SBRT) for localized primary and oligometastatic lung tumors by assessing efficacy and safety of 5 regimens of varying fraction size and number. One-hundred patients with primary lung cancer (n = 69) or oligometastatic lung tumors (n = 31), who underwent SBRT between May 2003 and August 2010, were included. The median age was 75 years (range, 45–88). Of them, 98 were judged to have medically inoperable disease, predominantly due to chronic illness or advanced age. SBRT was performed using 3 coplanar and 3 non-coplanar fixed beams with a standard linear accelerator. Fraction sizes were escalated by 1 Gy, and number of fractions given was decreased by 1 for every 20 included patients. Total target doses were between 50 and 56 Gy, administered as 5–9 fractions. The prescribed dose was defined at the isocenter, and median overall treatment duration was 10 days (range, 5–22). The median follow-up was 51.1 months for survivors. The 3-year local recurrence rates for primary lung cancer and oligometastasis was 6 % and 3 %, respectively. The 3-year local recurrence rates for tumor sizes ≤3 cm and >3 cm were 3 % and 14 %, respectively (p = 0.124). Additionally, other factors (fraction size, total target dose, and BED10) were not significant predictors of local control. Radiation pneumonia (≥ grade 2) was observed in 2 patients. Radiation-induced rib fractures were observed in 22 patients. Other late adverse events of greater than grade 2 were not observed. Within this dataset, we did not observe a dose response in BED10 values between 86.4 and 102.6 Gy. SBRT with doses between 50 and 56 Gy, administered over 5–9 fractions achieved acceptable tumor control without severe complications

  17. Impact of lesion morphology on angiographic and clinical outcomes in patients with chronic total occlusion after recanalization with drug-eluting stents: a multislice computed tomography study

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Tsuyoshi [Toyohashi Heart Center, Toyohashi (Japan); Nagoya City University Graduate School of Medical Sciences, Department of Cardio-Renal Medicine and Hypertension, Nagoya (Japan); Tsuchikane, Etsuo; Nasu, Kenya; Kimura, Masashi; Terashima, Mitsuyasu; Kinoshita, Yoshihisa; Habara, Maoto; Suzuki, Takahiko [Toyohashi Heart Center, Toyohashi (Japan); Suzuki, Yoriyasu; Ehara, Mariko [Nagoya Heart Center, Nagoya (Japan); Ohte, Nobuyuki [Nagoya City University Graduate School of Medical Sciences, Department of Cardio-Renal Medicine and Hypertension, Nagoya (Japan)

    2015-10-15

    The aim of this study was to investigate the multislice computed tomography (MSCT) parameters associated with adverse outcomes after chronic total occlusion percutaneous coronary intervention (CTO-PCI) with drug-eluting stents. A total of 285 patients who underwent MSCT before CTO-PCI were analyzed. Lesion morphology was assessed with MSCT. Angiographic restenosis, reocclusion, and MACE (a composite of cardiac death, myocardial infarction, stent thrombosis, and target lesion revascularization) were analyzed. MACE was observed in 36 patients (13.6 %). Occlusion length was greater (39.5 ± 19.9 mm vs. 22.3 ± 13.7 mm, p < 0.01), minimal vessel area smaller (11.2 ± 5.7 mm{sup 2} vs. 14.5 ± 5.6 mm{sup 2}, p < 0.01), and severe calcification more common (36 % vs. 12 %, p < 0.01) in the MACE group compared to the non-MACE group. We defined occluded length >25.4 mm, minimal vessel area <11.9 mm{sup 2}, which were identified by receiver operating characteristic analysis, and severe calcification as CT-derived risk factors. Angiographic restenosis (60 % vs. 12 % vs. 7 %, p < 0.01), reocclusion (29 % vs. 2 % vs. 2 %, p < 0.01), and MACE (43 % vs. 6 % vs. 3 %, p < 0.01) were more common in patients with 2 or more risk factors than in those with 1 or 0. MSCT characteristics associated with adverse outcomes after CTO-PCI were occlusion length, minimal vessel area, and severe calcification. (orig.)

  18. CLINIC-MORPHOLOGICAL ANALYSIS OF THE APPLICATION OF THE MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW CELLS IN ENDOMYOCARDIAL IMPLANTATION IN A PATIENT WITH SEVERE ISCHEMIC MYOCARDIAL DYSFUNCTION OF THE LEFT VENTRICLE

    Directory of Open Access Journals (Sweden)

    Ye. N. Kliever

    2015-01-01

    Full Text Available Aim. The purpose of this study is to conduct clinic-morphological analysis following intramyocardial administration of a mononuclear fraction of bone marrow stem cells in a CHF patient suffering from ischemic heart disease. In October 2007 the patient underwent surgery, with a mononuclear fraction of bone marrow stem cells implanted with the use of a NOGA system. The patient was then put on a waiting list for heart transplantation. After 2-year follow-up amelioration was observed, LVEF increased from 22 to 27%, LF end systolic volume dropped from 265 ml to 250 ml. All these positive developments indicated the stabilization of hemodynamic indicators and enabled to wait for orthotopic heart transplantation which was performed in December 2009. 

  19. Auricular or body acupuncture: which one is more effective in reducing abdominal fat mass in Iranian men with obesity: a randomized clinical trial

    OpenAIRE

    Darbandi, Mahsa; Darbandi, Sara; Owji, Ali Akbar; Mokarram, Pooneh; Mobarhan, Majid Ghayor; Fardaei, Majid; Zhao, Baxiao; Abdi, Hamid; Nematy, Mohsen; Safarian, Mohammad; Parizadeh, Mohammad Reza; Dabbaghmanesh, Mohammad Hossein; Abbasi, Parisa; FERNS, Gordon

    2014-01-01

    Background The prevalence of abdominal obesity is on the rise worldwide. Previous studies have indicated the higher diagnostic value of body fat distribution pattern compared with general body in abdominal obesity assessments. Several non-pharmacological methods have been suggested for obesity management, of which acupuncture has gained a great deal of research interest with promising results. This study aimed to comparatively evaluate the effects of conventional auricular and body electroacu...

  20. Body image flexibility moderates the association between disordered eating cognition and disordered eating behavior in a non-clinical sample of women: a cross-sectional investigation.

    Science.gov (United States)

    Moore, Makeda; Masuda, Akihiko; Hill, Mary L; Goodnight, Bradley L

    2014-12-01

    Body image flexibility, a regulation process of openly and freely experiencing disordered eating thoughts and body dissatisfaction, has been found to be a buffering factor against disordered eating symptomatology. The present cross-sectional study investigates whether body image flexibility accounts for disordered eating behavior above and beyond disordered eating cognition, mindfulness, and psychological inflexibility in a sample of nonclinical women, and whether body image flexibility moderates the associations between these correlates and disordered eating behavior. Participants were 421 women, age 21±5.3 years old on average, who completed a web-based survey that included the self-report measures of interest. Results demonstrate the incremental effects of body image flexibility on disordered eating behavior above and beyond disordered eating cognition, mindfulness, and psychological inflexibility. Women with greater body image flexibility endorse disordered eating behavior less so than those with lower body image flexibility. Body image flexibility moderates the association between disordered eating cognition and disordered eating behavior; for women with greater body image flexibility, disordered eating cognition is not positively associated with disordered eating behavior.

  1. A technique for measuring total-body nitrogen in clinical investigations using the 14N(n, 2n) 13N reaction

    International Nuclear Information System (INIS)

    The radioactivity induced in subjects by irradiation with 14 MeV neutrons is measured in a Whole-body Radiation Counter and analysed into its separate activities. Total-body nitrogen is estimated from the annihilation spectrum after corrections for interfering reactions and the subject's body build. Total-body potassium is also derived from the spectrum following irradiation but using the contribution from its natural activity. The method is compared with that at another centre which uses the 14N (n, γ) 15N reaction. The procedure is being used to investigate nitrogen metabolism in critically-ill surgical patients and those receiving hyperalimentation. (author)

  2. Clinical and morphological investigations on the incidence of forms of rickets and their association with other pathological states in broiler chickens.

    Science.gov (United States)

    Dinev, I

    2012-04-01

    The purpose of investigations was to determine, by means of pathomorphological methods, the incidence of different rickets forms and their role for the occurrence of other illnesses in broiler chickens in Bulgaria. Clinical, blood biochemical, gross anatomy and histological investigations were carried out in broiler chickens with signs of rickets. The studies were performed in 12 broiler flocks in 4 farms located in different regions of the country. Based on macro- and microscopic lesions, alterations specific for hypocalcaemic rickets were observed in two farms, whereas signs of hypophosphataemic rickets - in the other two. The rickets diagnosis was confirmed by analysis of blood serum calcium, magnesium and inorganic phosphate concentrations. At the age of 30-35 days, various pathological states were observed in the same farms. The presented results suggested that existing problems in studied flocks were associated with an earlier occurrence of rickets.

  3. Severity assessment of pulmonary embolism using dual energy CT - correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure

    Energy Technology Data Exchange (ETDEWEB)

    Thieme, Sven F. [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Institut fuer Klinische Radiologie der LMU Muenchen, Muenchen (Germany); Ashoori, Nima; Bamberg, Fabian; Sommer, Wieland H.; Johnson, Thorsten R.C.; Maxien, Daniel; Helck, Andreas D.; Reiser, Maximilian F.; Nikolaou, Konstantin [Ludwig-Maximilians-Universitaet, Department of Clinical Radiology, Muenchen (Germany); Leuchte, Hanno; Becker, Alexander [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Behr, Juergen [Ludwig-Maximilians-Universitaet, Department of Medicine I, Muenchen (Germany); Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH Ruhr-Universitaet Bochum, Department of Medicine III, Bochum (Germany)

    2012-02-15

    To correlate a Dual Energy (DE)-based visual perfusion defect scoring system with established CT-based and clinical parameters of pulmonary embolism (PE) severity. In 63 PE patients, DE perfusion maps were visually scored for perfusion defects (P-score). Vascular obstruction was quantified using the Mastora score. Both scores were correlated with short-axis diameters of the right and left ventricle, their ratio (RV/LV ratio), width of the pulmonary trunk, a number of clinical parameters and each other. Univariate and multivariate analyses were performed. Times to generate both scores were recorded. After univariate and multivariate analysis, a significant (p < 0.05) correlation with the P-score was shown for the Mastora score (r = 0.65), RV/LV ratio (r = 0.47), width of the pulmonary trunk (r = 0.26), troponin I (r = 0.43) and PaO{sub 2} (r = -0.50). For the left ventricular diameter, only univariate analysis showed a significant correlation. Mastora score correlated significantly with RV/LV ratio (r = 0.36), width of the pulmonary trunk (r = 0.27), PaO{sub 2} (r = -0.41) and troponin I (r = 0.37). Mean time for generating the P-score was significantly shorter than for the Mastora score. A DE-based P-score correlates with a number of parameters of PE severity. It might be easier and faster to perform than some traditional CT scoring methods for vascular obstruction. (orig.)

  4. Imaging assessment and clinical application of body composition in cancer patients%肿瘤患者身体组分的影像学评估和临床应用

    Institute of Scientific and Technical Information of China (English)

    高嫣; 于宗民; 刘正晔; 燕霞; 周福祥

    2016-01-01

    身体组分是评价肿瘤患者营养状况的重要参考指标。本文总结了常用的测量身体组分的方法,归纳了肿瘤患者身体组分评估的临床价值和应用前景。CT和MRI具有较高的组织分辨率和测量准确性,是身体组分评价的金标准。身体组分可以预测患者对治疗的耐受性;基于身体组分的营养评估,如内脏肥胖、肌肉减少症和肌肉减少性肥胖被认为是肿瘤患者的不良预后因素。身体组分有望成为肿瘤治疗副反应和生存的预测因子,但其临床应用还需要大规模临床试验证实和多学科合作。%Body composition is an important reference for evaluating nutritional status of cancer patients. We summarized the various methods of body composition assessment and its clinical applications in oncology. CT and MRI are the current gold standard in body composition evaluation with its high spatial and contrast resolution. Body composition can be used to predict chemotherapy tolerance; Nutrition evaluation based on body composition such as visceral obesity, sarcopenia and sarcopenia obesity are considered to be adverse prognostic factors in cancer patients. Body composition may be a significant predictor of treatment toxicities and prognosis, but its clinical application needs multidisciplinary cooperation and more well-designed prospective clinical trials.

  5. Clinical strategies for pediatric soft-tissue foreign body: Report of 165 cases%165例小儿软组织异物的临床策略

    Institute of Scientific and Technical Information of China (English)

    杨秀军; 邢光富; 李巍; 史常文

    2011-01-01

    Objective To evaluate the past 5 years' clinic experience of diagnosis and treatment of the pediatric soft-tissue foreign body (STFB),and to probe new strategies for its clinical management.Methods Totally 165 consecutive children with small radiopaque STFB were involved.All the children were diagnosed with X-rays.CT (enhanced CT in 9 children)and virtual anatomy imaging (VAI) were performed in 40 children.Percutaneous foreign body forceps removal guided with C-arm video-fluoroscopy was performed and the effect was evaluated.Results The longest dimension of STFB ranged from 1 mm to 40 mm,and the shortest dimension ranged from 1 mm to 5 mm,including scrap-iron,broken iron nails and needles,and glass pieces embedded in soft tissues under surface of the limbs,neck,chest,abdomen and pelvis.Seventy-six (76/165,46.06 %) children received interventional therapy,and 73 were completely cured (73/76,96.05 %),2 were partially cured (2/76,2.63 %),and 1 was failed (1/76,1.32 %).VAI accurately depicted STFB closely to large vessels even associated vascular complication with local large hematomas or pseudoaneurysms,helped to select the treatment methods and the forceps removal roads.Hematoma,infection,neural damages and other serious complications did not occur during and after operation.Conclusion Video-fluoroscopy-guided percutaneous foreign body forceps removal is minimally invasive,safe and effective for small radiopaque STFBs,but may not suitable for the one very close to large blood vessels with or without vascular injuries complications.Preoperative CT VAI is helpful to locate STFB within complicated anatomic structures,selecting optimal intervention pathway and assessing the risk of intervention.%目的分析近5年小儿软组织异物诊疗经验,探讨临床新策略.方法 我院连续诊治≤16岁软组织不透X线异物患儿165例,均经X线平片确认,40例加行CT(9例增强)扫描及仿真局部解剖评价.采用C臂机X线透视引导下经皮异

  6. The limits on trypanosomatid morphological diversity.

    Directory of Open Access Journals (Sweden)

    Richard John Wheeler

    Full Text Available Cell shape is one, often overlooked, way in which protozoan parasites have adapted to a variety of host and vector environments and directional transmissions between these environments. Consequently, different parasite life cycle stages have characteristic morphologies. Trypanosomatid parasites are an excellent example of this in which large morphological variations between species and life cycle stage occur, despite sharing well-conserved cytoskeletal and membranous structures. Here, using previously published reports in the literature of the morphology of 248 isolates of trypanosomatid species from different hosts, we perform a meta-analysis of the occurrence and limits on morphological diversity of different classes of trypanosomatid morphology (trypomastigote, promastigote, etc. in the vertebrate bloodstream and invertebrate gut environments. We identified several limits on cell body length, cell body width and flagellum length diversity which can be interpreted as biomechanical limits on the capacity of the cell to attain particular dimensions. These limits differed for morphologies with and without a laterally attached flagellum which we suggest represent two morphological superclasses, the 'juxtaform' and 'liberform' superclasses. Further limits were identified consistent with a selective pressure from the mechanical properties of the vertebrate bloodstream environment; trypanosomatid size showed limits relative to host erythrocyte dimensions. This is the first comprehensive analysis of the limits of morphological diversity in any protozoan parasite, revealing the morphogenetic constraints and extrinsic selection pressures associated with the full diversity of trypanosomatid morphology.

  7. 稽留流产超声形态学表现及临床应用%Missed Abortion Ultrasound Morphology and Its Clinical Application

    Institute of Scientific and Technical Information of China (English)

    郑敏

    2014-01-01

    目的:探讨稽留流产的超声表现,及时诊断出胚胎、胎儿停止发育或胚胎残留,配合临床及时采取合理治疗措施和治疗中的超声监测,减少产妇的并发症。方法回顾性分析经手术或病理证实的183例稽留流产患者的临床资料及声像图表现。总结其超声特点及超声辅助的治疗方法。结果稽留流产声像表现根据其影像特点分为四型:胚胎停止发育型,孕囊平均直径>2.0cm,囊内可见胚芽存在,未探及原始心管搏动,其中孕囊平均直径<1.0cm者,囊内未见胚芽或仅见卵黄囊存在,经过1~2w观察孕囊不增大者,应考虑胚胎停止发育。枯萎孕卵型,宫腔内孕囊圆而饱满(>8w),内无胎芽或仅见一小胎块[1-2]。胎儿停止发育型,胎儿形态可辨但已去常态,实时超声检查看不到胎心搏动或胎动。杂乱回声型,宫腔内既看不清胎儿也看不清胎盘组织,只见混乱一团结构。所有稽留流产患者均经超声及临床资料证实,治疗均口服米非司酮配伍米索前列醇终止妊娠,3d后复查阴道彩超。其中有57例患者阴道彩超诊断宫腔残留物,采用经腹超声引导下清宫处理。所有患者均建议1w后彩超复查。结论超声对稽留流产的认识具有重要的临床意义,在选择治疗方案指导治疗及治疗后随诊方面起重要作用。%Objective Discussion on ultrasonic manifestation of missed abortion, prompt diagnosis the embryos stop developing or residual embryos, timely take reasonable remedial measures and clinical ultrasound monitoring during treatment, reduction of maternal complications. Methods Retrospective analysis of surgery or pathology of the 183 cases of missed abortion patient's clinical data and imaging performance. Results Characteristics summarized its ultrasound and ultrasound-assisted treatments. Missed abortion video based on its imaging features are grouped into four

  8. Morphological features in children with autism

    NARCIS (Netherlands)

    Özgen, Mihriban Heval

    2008-01-01

    The central research aim in the present thesis was to extend the insight in several aspects of the role of the morphological features in autism. Clinical morphology might be used as a biomarker for ASD to reveal insight into the complexity of the disorder. In Chapter 1 current terminology and classi

  9. 超声诊断胎儿半椎体的临床价值%Ultrasonic diagnosis of fetus half the clinical value of the vertebral bodies

    Institute of Scientific and Technical Information of China (English)

    吴明烨; 张燕

    2015-01-01

    vertebral body,which can make multiple or single vertebral involvement,common for thoracic vertebra,at the same time may be accompanied by missing rib. Conclusion Half vertebral malformation fetus normalize the accuracy of prenatal ultrasound monitoring and MRI are close to,for genetic counseling and provide value reference of eugenic and superior nurture,has important clinical significance.%目的:探讨半椎体畸形胎儿应用产前规范化超声监测与检查的价值。方法入选2012年1月至2014年1月疑似半椎体胎儿孕妇20例,对所有研究对象予以规范化超声产前检查,产前进一步进行疑似椎体异常胎儿MRI检查,对足月娩出新生儿及引产后胎儿进行MR、CT或X线检查。比较产前MRI、超声检查,并比较产后影像学检查情况。结果20例胎儿均为半椎体畸形,单发者7例,其中受累胸椎3例,颈椎1例,骶椎1例,腰椎2例;合并唇裂、左侧异位肾、脑积水各1例;其余4例无其他系统合并畸形;多发者13例,受累颈椎3例,骶椎4例,腰椎1例,胸椎5例,合并神经系统畸形10例,包括无脑儿3例,脊膜膨出3例,脑积水1例,脊柱裂3例,合并泌尿系统畸形7例,包括重复肾1例、肾发育不良3例、肾缺如1例、异位肾2例,合并其他系统畸形3例,部分胎儿同时存在2个或超过2个系统畸形,无其他系统畸形者2例;产前超声诊断准确率为90.0%,产前MRI诊断准确率为95.0%,差异无统计学意义( P ﹥0.05);20例胎儿半椎体超声影像学特征表现为脊柱两侧强回声无法逐一对应,比正常椎体略小的三角形或椭圆形骨性强回声嵌入正常椎体内,可使多个或单一椎体受累,常见为胸椎,同时可伴有肋骨缺失。结论胎儿半椎体畸形进行规范化产前超声监测的准确性与MRI相接近,对于遗传咨询与优生优育提供价值参考,具有重要的临床意义。

  10. The Body as a Pulse

    Directory of Open Access Journals (Sweden)

    Flavia Liberman

    2010-01-01

    Full Text Available The body is the focus of many studies and interventions. Some paradigms conceptualize the body only in relation to its motor-sensory characteristics, while others prioritize its psychological dimensions. With the aim of contributing towards formulating other perspectives within this field, some aspects of Stanley Keleman and Regina Favre's conceptualization of the body are presented here. Starting from clinical situations during seminar groups, we can take the body to be a multifaceted multimedia pulse that is continually [de]constructed through encounters. Together with the author's clinical experiences as an occupational therapist and teacher or undergraduates, these conceptualizations serve as a guide to clinical practice that is thought out, constructed and balanced by the body, using body approaches to promote encounters molded by affections and events, in an attempt to create bodies capable of sustaining the lived intensity of experiences, and which enable self-observation, closeness to other people and production of singularities.

  11. Implicit body representations and the conscious body image

    OpenAIRE

    Longo, M. R.; Haggard, P.

    2012-01-01

    Recent studies have revealed that somatosensory processing relies on a class of implicit body representations showing large distortions of size and shape. The relation between these representations and the conscious body image remains unclear. Dissociations have been reported in the clinical literature on eating disorders between different body image measures, with larger and more consistent distortions found with depictive measures, in which participants compare their body to a visual depict...

  12. Body Hygiene

    Science.gov (United States)

    ... Home Diaper-Changing Steps for Childcare Settings Body Hygiene Dental Hygiene Water Fluoridation Facial Cleanliness Fish Pedicures and ... spread of hygiene-related diseases . Topics for Body Hygiene Facial Cleanliness Dental Hygiene Water Fluoridation Fish Pedicures and Fish Spas ...

  13. Body Image

    Science.gov (United States)

    ... Help your child have a healthy body image Cosmetic surgery Breast surgery Botox Liposuction Varicose or spider veins Body dysmorphic disorder (BDD) Eating disorders Anorexia nervosa Binge eating ... nervosa Cosmetics and your health Depression during and after pregnancy ...

  14. Body Basics

    Science.gov (United States)

    ... about how the body works, what basic human anatomy is, and what happens when parts of the body don't function properly. Blood Bones, Muscles, and Joints Brain and Nervous System Digestive System Endocrine System Eyes Female Reproductive System ...

  15. Body embellishment

    OpenAIRE

    Zellweger, Christoph

    2015-01-01

    The exhibition Body Embellishment explores the most innovative artistic expression in the 21st-century international arenas of body extension, augmentation, and modification, focusing on jewelry, tattoos, nail arts, and fashion. The areas of focus are jewelry, tattoos, nail arts, and fashion. Avant-garde jewelry consciously engages the body by intersecting and expanding the planes of the human form. Tattoos are at once on and in the body. Nail art, from manicures to pedicures, has humble ...

  16. Body Clock

    Institute of Scientific and Technical Information of China (English)

    刘洪毓

    2000-01-01

    Body clocks” are biological methods of controling body activities.Every living thing has one. In humans, a body clock controls normal periods of sleeping and waking. It controls the time swhen you are most likely to feel pain.Eating, sleeping and exercising at about the same time each day will help keep body activities normal. But changes in your life, a new job, for example, destroy the balance and thus cause health problems.

  17. 软组织内非金属异物嵌入伤MRI检出及其临床价值%Clinical value of MR imaging for detection of the non-metal foreign bodies embedded in soft tissues

    Institute of Scientific and Technical Information of China (English)

    章宏; 鲁国卫; 程平章; 孙世介; 胡丽春

    2011-01-01

    目的:探讨软组织内非金属异物嵌入伤MRI检出及其临床价值.方法:对6例患者分别行X线及MRI检查,对照分析MRI影像特征及手术结果.结果:6例患者X线检查均为阴性,MRI发现6处异物(6个)均经手术证实,异物发现率100%.6例异物于T1WI上呈略高信号,T2WI上呈等信号或稍低信号,STIR像上均呈低信号,其周围可见高信号且有环形低信号包绕,其中1例膝关节在T2·W1上亦可见相似信号.结论:MRI检查是诊断软组织内非金属异物有效且可靠的检查方法,并对相邻结构的损伤程度显示清楚,为临床诊断治疗提供有利依据.%Objective: To explore the clinical value of MR imaging for detection of the non-metal foreign bodies em bedded in soft tissues. Methods: The X-ray radiography and MR imaging were performed for six patients with suspicious foreign bodies in soft tissues. The MR imaging characteristics were analyzed in comparison to the surgical results. Results: The six patients were negative on the X-rays,while the MR imaging revealed one foreign body in each patient in this group, and the foreign body detection race by MR imaging was 100%. The foreign bodies in the 6 cases showed slight hyperintensi ty on T1WI and iso- or slightly hypo-inlensity on T2WI. All the foreign bodies showed hypointensity on STIR image with hyperintense changes around and surrounded by a hypointense ring, similar findings were detected on T2·WI in one case with foreign body in the knee. Conclusion:MR imaging is an effective and reliable screening method to detect the non-metal foreign bodies embedded in soft tissues. And it can sensitively demonstrate the damage degree of adjacent structures clearly which provides useful evidence for clinical diagnosis and therapy.

  18. Current Situation and Assessment of the Clinical Study on the Chinese Medicine Body Constitution of Diabetes%糖尿病中医体质的临床研究现状与评价

    Institute of Scientific and Technical Information of China (English)

    李军; 金艳蓉; 曹芸; 李雷

    2013-01-01

    文章对近年来发表的糖尿病中医体质临床研究文献,进行了全面的总结及循证医学的分析与评价.相关的研究显示:糖尿病患者的中医体质多以气虚质、阴虚质及痰湿质为主;不同体质类型之间,其血脂水平、血凝指标、体质指数和年龄可能存在差异;在伴有微血管并发症的糖尿病患者中,其主要体质为气虚质、痰湿质、血瘀质和阳虚质;中医体质干预对血糖、糖化血红蛋白、血脂、血压及体重有一定的效果.由于这些研究在研究设计、统计.方法 学的选择和样本的来源方面都存在缺陷,所以其证据强度不够高.因此,需要更多的设计严谨的临床研究,来明确中医体质在糖尿病防治中的作用.%The overall summarization and the analysis and assessment of the evidence-based medicine were conducted in the paper on the literatures of the clinical study of Chinese medicine body constitution of diabetes. The relevant researches indicated; the common Chinese medicine body constitutions of diabetes patients were qi deficiency,yin deficiency and phlegm damp. Among the different body constitutions,the potential differences happened in blood lipid,clotting index,body mass index and age. For the patients with mi-crovascular complications,the main body constitutions were qi deficiency,phlegm damp,blood stagnation and yang deficiency. The intervention of Chinese medicine body constitution has achieved a certain effect on blood glucose,glycosylated hemoglobin, blood lipid, blood pressure and body weight. Because of the limitations on the research design, statistical methodology and source of sample in these researches, the evidences were not strong enough. Hence,the clinical researches of more precise designs arc; required to determine the role of Chinese medicine body constitution in the prevention and treatment of diabetes.

  19. Prevalence of Cam Morphology in Females with Femoroacetabular Impingement

    Directory of Open Access Journals (Sweden)

    David M Levy

    2015-12-01

    Full Text Available Cam and pincer are two common morphologies responsible for femoroacetabular impingement. Previous literature has reported that cam deformity is predominantly a male morphology, while being significantly less common in females. The purpose of this study was to determine the prevalence of cam morphology in female subjects diagnosed with symptomatic FAI. All females presenting to the senior author’s clinic diagnosed with symptomatic FAI between December 2006 and Cam and pincer are two common morphologies responsible for femoroacetabular impingement. Previous literature has reported that cam deformity is predominantly a male morphology, while being significantly less common in females. Cam morphology is commonly assessed with the alpha angle, measured on radiographs. The purpose of this study was to determine the prevalence of cam morphology utilizing the alpha angle in female subjects diagnosed with symptomatic FAI. All females presenting to the senior author’s clinic diagnosed with symptomatic FAI between December 2006 and January 2013 were retrospectively reviewed. Alpha (α angles were measured on AP (anteroposterior and lateral (Dunn 90°, cross-table lateral, and/or frog-leg lateral plain radiographs by two blinded physicians, and the largest measured angle was used. Using Gosvig et al.’s classification, alpha angle was characterized as (pathologic > 57°, borderline (51-56°, subtle (46-50°, very subtle (43-45°, or normal (≤42°. Three hundred and ninety-one patients (438 hips were analyzed (age 36.2 ± 12.3 years. Among the hips included, 35.6% were normal, 14.6% pathologic, 15.1% borderline, 14.6% subtle, and 20.1% very subtle. There was no correlation between alpha angle and patient age (R = 0.17 or body mass index (BMI (R = 0.05. The intraclass correlation coefficient (ICC for α-angle measurements was 0.84. Sixty-four percent of females in this cohort had an alpha angle > 42°. Subtle cam deformity plays a significant role in

  20. 路易体痴呆33例临床及影像学特点%Clinical features and treatment of dementia with Lewy bodies

    Institute of Scientific and Technical Information of China (English)

    李凌; 王景涛; 张振馨; 崔瑞雪; 袁晶

    2011-01-01

    目的 总结路易体痴呆的临床及影像学特点,探讨早期诊治办法.方法 对2006年 2月至2011年1月于北京协和医院诊断的33例很可能的路易体痴呆患者的临床资料进行回顾性分析.结果 男性25例,确诊时平均病程3.3年.10例患者发病前经历1~10年不等的睡眠障碍、抑郁、焦虑及便秘.首发症状为记忆障碍(52%),帕金森样症状(21%)或二者同时.以记忆障碍首发的患者出现帕金森症状平均时间为17个月.帕金森样症状主要表现为轴性肌张力增高,可在2~3年累及言语、吞咽和行走功能.幻觉(70%)、睡眠障碍(63%)、淡漠(56%)、妄想(52%)是主要精神行为症状,幻觉平均在发病后15个月内出现.半数患者认知障碍进展迅速.轻度患者视空间能力受损显著重于记忆障碍,中重度患者认知功能全面受损.头颅核磁显示海马结构相对保留,PET表现为枕叶代谢减低.乙酰胆碱酯酶抑制剂治疗可以改善患者认知和精神症状.结论 路易体痴呆在发病前期就可出现神经功能异常.幻觉出现早、睡眠障碍发生率高、轴性肌张力增高为主和PET发现枕叶低代谢是有助于和其他痴呆鉴别的临床特征.%Objective To investigate the clinical, neuropsychological, neuroimaging features and treatment of dementia with Lewy bodies (DLB).Methods The clinical, neuropsychological, neuroimaging and therapeutic features of 33 DLB patients were retrospectively analyzed.Results There were 25 males and 8 females.The mean course from onset to diagnosis was 3.3 years.Sleep disorder, depression, anxiety and constipation were present at 1-10 years prior to DLB onset in 10 patients.Memory impairment (52%) and parkinsonism (21%) were initial symptoms.The mean duration from memory impairment to presence of parkinsonism was 17 months.Pattern of extrapyramidal signs showed bilateral, symmetry and axial muscles bias as postural instability and facial impassivity, tremor was less in

  1. Clinical and morphologic evaluation of Er:YAG laser action at the front of cervical dentinal hypersensitivity; Avaliacao clinica e morfologica da acao do laser de Er:YAG frente a hipersensibilidade dentinaria cervical

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, Dalva Maria

    2001-07-01

    This work was achieved in vivo and in vitro to evaluate the efficiency of Er:YAG laser in the cervical dentinal hypersensitivity treatment (HSDC). The Clinical study was achieved in patients with HSDC. The treatment was realized in five sessions: the first for selection, the second for exams (clinic and X-Ray) and trying to remove the etiologic factors that could cause the HSDC. The third and fourth sessions were subjected to the radiation with that protocol: 60 mJ energy ,2 Hz frequency, 6 mm out of focus, under air cooling, 20 seconds each application which the same was repeated four times with one minute breaks, which scanning movements and without using anaesthetics. The fifth was evaluation. The patients were evaluated and registered in a subject scale of pain 0 to 3, in the beginning and end of each session of irradiation, and one month after the last session. The results showed that for the irradiated group occurs significant differences in the beginning of each session and between. For the control group did not occur significant differences in the beginning and after each session, but did show a difference between the sessions. As the control group as the irradiated group, had reduction of sensibility between the session. For the morphologic study nine teeth were selected, 7 molars and 2 pre-molars from operative dentistry discipline. Half of the surface was irradiated with Er:YAG laser, the same protocol used in vivo, and the other half was used as a control without receiving any laser irradiation. Subsequently, specimens were prepared for SEM examinations. The results showed that laser treated surfaces showed a reduction of dentine tubular diameter with partial or total closure of the dentine tubules. For the control group, it was observed bigger amounts smear layer and open dentine tubular. The results obtained indicated that the Er:YAG laser can contribute to the HSDC treatment. (author)

  2. Gamma Knife radiosurgery for cerebral arteriovenous malformations in children/adolescents and adults. Part I: Differences in epidemiologic, morphologic, and clinical characteristics, permanent complications, and bleeding in the latency period

    International Nuclear Information System (INIS)

    Purpose: To compare the epidemiologic, morphologic, and clinical characteristics of 92 children/adolescents (Group A) and 362 adults (Group B) with cerebral arteriovenous malformations (cAVMs) considered suitable for radiosurgery; to correlate radiosurgery-related permanent complication and post-radiosurgery bleeding rates in the 75 children/adolescents and 297 adults available for follow-up. Methods and Materials: Radiosurgery was performed with a model C 201-source Co6 Leksell Gamma Unit (Elekta Instruments, Stockholm, Sweden). Fisher exact two-tailed, Wilcoxon rank-sum, and two-sample binomial exact tests were used for statistical analysis. Results: There were significant differences between the two populations in sex (p = 0.015), clinical presentation (p = 0.001), and location (p = 0.008). The permanent complication rate was lower in younger (1.3%) than in older patients (5.4%), although the difference was not significant (p = 0.213). The postradiosurgery bleeding rate was lower in Group A (1.3%) than in Group B (2.7%) (p = 0.694), with global actuarial bleeding rates of 0.56% per year and 1.15% per year, respectively. Conclusions: The different characteristics of child/adolescent and adult cAVMs suggest that they should be considered two distinct vascular disorders. The similar rates of radiosurgery-related complications and latency period bleeding in the two populations show that gamma knife radiosurgery does not expose young patients to a higher risk of sequelae than that for older patients

  3. Body Dysmorphic Disorder

    Directory of Open Access Journals (Sweden)

    Perihan Cam Ray

    2012-12-01

    Full Text Available Body dysmorphic disorder is a type of mental illness, wherein the affected person is concerned with body image, manifested as excessive concern about and preoccupation with a perceived defect of their physical features. Although it is a common disease and has been defined in the literature over a century, it is not a well known disease. Chronic, treatment resistant and sometimes delusional nature could result in severe functional impairment. The diagnosis and appropriate therapy of disorder are crucial because of increased suicidality and reduction in life quality. In this article the symptoms, etiology, clinical features and treatment of body dysmorphic disorder are briefly reviewed.

  4. Cortical Lewy Body Dementia

    Directory of Open Access Journals (Sweden)

    W. R. G. Gibb

    1990-01-01

    Full Text Available In cortical Lewy body dementia the distribution of Lewy bodies in the nervous system follows that of Parkinson's disease, except for their greater profusion in the cerebral cortex. The cortical tangles and plaques of Alzheimer pathology are often present, the likely explanation being that Alzheimer pathology provokes dementia in many patients. Pure cortical Lewy body dementia without Alzheimer pathology is uncommon. The age of onset reflects that of Parkinson's disease, and clinical features, though not diagnostic, include aphasias, apraxias, agnosias, paranoid delusions and visual hallucinations. Parkinsonism may present before or after the dementia, and survival duration is approximately half that seen in Parkinson's disease without dementia.

  5. A novel point mutation in the translation initiation codon of the pre-pro-vasopressin-neurophysin II gene: Cosegregation with morphological abnormalities and clinical symptoms in autosomal dominant neurohypophyseal diabetes insipidus

    Energy Technology Data Exchange (ETDEWEB)

    Rutishauser, J.; Boeni-Schnetzler, M.; Froesch, E.R.; Wichmann, W.; Huisman, T. [Univ. of Zuerich (Switzerland)] [and others

    1996-01-01

    Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is a rare variant of idiopathic central diabetes insipidus. Several different mutations in the human vasopressin-neurophysin II (AVP-NP II) gene have been described. We studied nine family members from three generations of an ADNDI pedigree at the clinical, morphological, and molecular levels. AVP concentrations were measured during diagnostic fluid restriction tests. Coronal and sagittal high resolution T1-weighted images of the pituitary were obtained from affected and healthy family members. PCR was used to amplify the AVP-NP II precursor gene, and PCR products were directly sequenced. Under maximal osmotic stimulation, AVP serum levels were close to or below the detection limit in affected individuals. Magnetic resonance imaging studies revealed the characteristic hyperintense ({open_quotes}bright spot{close_quotes}) appearance of the posterior pituitary in two healthy family members. This signal was absent in all four ADNDI patients examined. The coding sequences of AVP and its carrier protein, neurophysin II, were normal in all family members examined. Affected individuals showed a novel single base deletion (G 227) in the translation initiation codon of the AVP-NP II signal peptide on one allele. The mutation in the AVP-NP II leader sequence appears to be responsible for the disease in this kindred, possibly by interfering with protein translocation. The absence of the hyperintense posterior pituitary signal in affected individuals could reflect deficient posterior pituitary function. 56 refs., 4 figs., 3 tabs.

  6. Whole-body microvascular permeability of small molecules in man: clinical aspects, basic concepts and limitations of the single injection technique

    DEFF Research Database (Denmark)

    Henriksen, Jens Henrik Sahl

    1985-01-01

    In order to estimate whole-body permeability-surface area (PS) product, the initial slope of the plasma disappearance curve was determined after simultaneous i.v. injection of 24Na+ (mol.wt 24) and 51Cr-EDTA (mol.wt 342). Twelve subjects were studied. Plasma volume (PV) was measured by the indica...

  7. Neuronal ceroid lipofuscinoses: a clinical and morphological study of 17 patients from Southern Brazil Lipofuscinoses ceróides neuronais: estudo clínico e morfológico de 17 pacientes do Sul do Brasil

    Directory of Open Access Journals (Sweden)

    ANA CRISTINA S PUGA

    2000-09-01

    Full Text Available The neuronal ceroid lipofuscinoses (NCL are a group of inherited progressive neurodegenerative disorders with presentation from infancy to adulthood. Three main childhood forms can be established on the basis of age of onset, clinical course, and ultrastructural morphology: infantile (INCL, late infantile (LINCL, and juvenile (JNCL. Several variant subtypes have been described. Genetic and biochemical analysis are helping to better understand, diagnose and classify these disorders. We report on clinical, neurophysiological, neuroradiological, and morphological data from 17 patients with different forms (infantile, late infantile, and juvenile of neuronal ceroid lipofuscinoses (NCL evaluated at Hospital de Clínicas de Porto Alegre, Southern Brazil, during 6 years (1992-1997. Seven cases were infantile; 5 were late infantile; and 5 were juvenile NCL. Gender ratio was male:female, 11:6. Age at presentation varied from 2-24 months for INCL; 2,5 to 5 years for LINCL ; and 4-10 years for the JNCL cases. Seizures (6 patients and psychomotor retardation (1 patient were the initial symptoms in the INCL group. All the patients in the group of LINCL had the usual findings. JNCL patients manifested different initial symptoms, although tending to follow a similar clinical picture within familial cases. Epidemiological data on the prevalence of NCLs in Brazil are not available, we expect this series of cases to contribute to further research in our population.As lipofuscinoses ceroides neuronais (LCN constituem um grupo de desordens neurodegenerativas, progressivas e de origem genética. O início dos sintomas varia desde a infancia até a vida adulta. Três principais formas infantis são estabelecidas com base na idade de início, evolução clínica e morfologia celular, através de microscopia eletrônica: infantil (LCNI, infantil tardia (LCNIT e juvenil (LCNJ. Vários subtipos têm sido descritos. Investigação genética e bioquímica vem

  8. 1990~2010年广州城市河流水体形态演化研究%The Morphological Evolution of River and Water Body in Urban Area of Guangzhou City in 1990-2010

    Institute of Scientific and Technical Information of China (English)

    陈昆仑; 王旭; 李丹; 薛德升

    2013-01-01

    The shapes of urban rivers and water body were deeply affected by the rapid industrialization and urbanization in recent decades in Guangzhou. The article used topographic maps, remote sensing images and related socio-economic data as a basis data to research the space-time evolution of urban rivers and water body and its causes in Guangzhou in the past two decades. The results indicated that: 1) The changes of area of river and water bogy showed a slight increase trend in the first decade and a sharply reduce trend in the last decade, the area increased 9.11 km2 from 1990 to 2000, and reduced 32.37 km2 from 2000 to 2010. The water front length of river and water body showed a continuous reduce trend in the past two decades, the length reduced 26.49 km from 1990 to 2000 and 1 008.19 km from 2000 to 2010. The landscape shape index were 83.49 (1990), 80.19 (2000) and 71.83 (2010), which showed an accelerated decline trend, and indicated that the shape complexity of rivers and water body was decreasing and human intervention was strengthening in study area. 2) There were great differences between the changes of rivers and water body in different regions and periods. The increased parts from 1990 to 2000 mainly located in Baiyun and Luogang District in the outskirts of Guangzhou, because a lot of ponds had been excavated and porcelain clay lodes had been exploited in those areas. In 2000-2010, decrease happened in every district in study area as a common trend. The rate and speed of change in Tianhe District is the biggest in the past two decades, and that coincided with the "East" development direction of Guangzhou. 3) The changes of rivers and water body in study area were mainly affected by human activities. The reduced parts contain the occupation of the built-up areas, and increased parts contain new ponds, porcelain cay pits, new landscape water body and other water body for special uses.%近几十年来的快速工业化和城市化进程深刻地影响了广

  9. Clinical experience of ocular trauma with metallic arrow-headed foreign bodies%眼部弓箭射伤诊治的体会

    Institute of Scientific and Technical Information of China (English)

    林育华

    2011-01-01

    Objective To discuss surgical treatments of patients with orbital foreign bodies. Methods We analyzed 7 cases(7 eyes) of eye injury with arrow-head foreign body.The huge foreign body (arrows)was extracted after soft tissue separation was done or the removal of arrows was together with enucleation. Results Arrows were completely removed in all the patients. No sight-threatening to patients if there was no eyeball injury. The sight was lost in patients with eyeball rupture. Craniocerebral trauma and neurological complications occurred on the basis of the depth of the arrows in the patients' eyes. Conclusion It is rare that arrows are orbital foreign bodies,which should be removed timely by surgery. Computer tomography (CT) examination should done before the operation. The method of operation depends on the eye injury positions and the accompanied eyeball double perforation and craniocerebral trauma.%目的 探讨眼部弓箭射伤的手术治疗方法.方法 7例(7眼)眼部弓箭伤进行分析.7例眼部巨大异物(箭)分别采用分离软组织后拔出和眼球摘除同时拔出异物(箭).结果 7例均完整取出弓箭异物,不伤及眼球者视力完好,眼球破裂者视力丧失,伴颅脑损伤者有神经并发症.结论 眼部弓箭射伤是罕见的眼部巨大异物,需及时手术取出,术前行CT检查,手术的方式根据箭伤及的部位和是否伴有眼球贯通和颅脑伤.

  10. Effects of L- Arginine Supplementation on Antioxidant Status and Body Composition in Obese Patients with Pre-diabetes: A Randomized Controlled Clinical Trial

    OpenAIRE

    Siavash Fazelian; Mostafa Hoseini; Nazli Namazi; Javad Heshmati; Mehdi Sepidar Kish; Maryam Mirfatahi; Ahmad Saedi Some Olia

    2014-01-01

    Purpose: The aim of present study was to determine effects of L-Arginine supplementation on antioxidant status and body composition in obese patients with prediabetes. Methods: A double-blind randomized control trial was performed on 46 (24 men, 22 women) obese patients with prediabetes. They were divided randomly into two groups. Patients in intervention (n = 23) and control group (n=23) received 3 gr/day L-arginine and placebo, respectively for 8 weeks. Anthropometric indices, dietary in...

  11. More Accurate Definition of Clinical Target Volume Based on the Measurement of Microscopic Extensions of the Primary Tumor Toward the Uterus Body in International Federation of Gynecology and Obstetrics Ib-IIa Squamous Cell Carcinoma of the Cervix

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Wen-Jia [Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Wu, Xiao [Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Xue, Ren-Liang; Lin, Xiang-Ying [Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Kidd, Elizabeth A. [Department of Radiation Oncology, Stanford University, Stanford, California (United States); Yan, Shu-Mei [Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province (China); Zhang, Yao-Hong [Department of Radiation Oncology, Chaozhou Hospital of Chaozhou City, Guangdong Province (China); Zhai, Tian-Tian; Lu, Jia-Yang; Wu, Li-Li; Zhang, Hao [Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Huang, Hai-Hua [Department of Pathology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Chen, Zhi-Jian; Li, De-Rui [Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China); Xie, Liang-Xi, E-mail: xieliangxi1@qq.com [Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Province (China)

    2015-01-01

    Purpose: To more accurately define clinical target volume for cervical cancer radiation treatment planning by evaluating tumor microscopic extension toward the uterus body (METU) in International Federation of Gynecology and Obstetrics stage Ib-IIa squamous cell carcinoma of the cervix (SCCC). Patients and Methods: In this multicenter study, surgical resection specimens from 318 cases of stage Ib-IIa SCCC that underwent radical hysterectomy were included. Patients who had undergone preoperative chemotherapy, radiation, or both were excluded from this study. Microscopic extension of primary tumor toward the uterus body was measured. The association between other pathologic factors and METU was analyzed. Results: Microscopic extension toward the uterus body was not common, with only 12.3% of patients (39 of 318) demonstrating METU. The mean (±SD) distance of METU was 0.32 ± 1.079 mm (range, 0-10 mm). Lymphovascular space invasion was associated with METU distance and occurrence rate. A margin of 5 mm added to gross tumor would adequately cover 99.4% and 99% of the METU in the whole group and in patients with lymphovascular space invasion, respectively. Conclusion: According to our analysis of 318 SCCC specimens for METU, using a 5-mm gross tumor volume to clinical target volume margin in the direction of the uterus should be adequate for International Federation of Gynecology and Obstetrics stage Ib-IIa SCCC. Considering the discrepancy between imaging and pathologic methods in determining gross tumor volume extent, we recommend a safer 10-mm margin in the uterine direction as the standard for clinical practice when using MRI for contouring tumor volume.

  12. More Accurate Definition of Clinical Target Volume Based on the Measurement of Microscopic Extensions of the Primary Tumor Toward the Uterus Body in International Federation of Gynecology and Obstetrics Ib-IIa Squamous Cell Carcinoma of the Cervix

    International Nuclear Information System (INIS)

    Purpose: To more accurately define clinical target volume for cervical cancer radiation treatment planning by evaluating tumor microscopic extension toward the uterus body (METU) in International Federation of Gynecology and Obstetrics stage Ib-IIa squamous cell carcinoma of the cervix (SCCC). Patients and Methods: In this multicenter study, surgical resection specimens from 318 cases of stage Ib-IIa SCCC that underwent radical hysterectomy were included. Patients who had undergone preoperative chemotherapy, radiation, or both were excluded from this study. Microscopic extension of primary tumor toward the uterus body was measured. The association between other pathologic factors and METU was analyzed. Results: Microscopic extension toward the uterus body was not common, with only 12.3% of patients (39 of 318) demonstrating METU. The mean (±SD) distance of METU was 0.32 ± 1.079 mm (range, 0-10 mm). Lymphovascular space invasion was associated with METU distance and occurrence rate. A margin of 5 mm added to gross tumor would adequately cover 99.4% and 99% of the METU in the whole group and in patients with lymphovascular space invasion, respectively. Conclusion: According to our analysis of 318 SCCC specimens for METU, using a 5-mm gross tumor volume to clinical target volume margin in the direction of the uterus should be adequate for International Federation of Gynecology and Obstetrics stage Ib-IIa SCCC. Considering the discrepancy between imaging and pathologic methods in determining gross tumor volume extent, we recommend a safer 10-mm margin in the uterine direction as the standard for clinical practice when using MRI for contouring tumor volume

  13. 'Bad boys'' Bodies

    DEFF Research Database (Denmark)

    Skårderud, Finn; Nygren, Pär; Edlund, Birgitta

    2005-01-01

    Children residing in care (hereafter referred to as childcare residents) are a risk¬group for emotional disturbances and behaviour problems. Based on existing knowledge of risk factors one would also expect this population to be a high-risk group for eating disorders and related body-image...... resident group; few differences between girls in the two samples; and a high frequency of having used anabolic?androgenic steroids among boys in care. Body-image problems among boys have hitherto been given little attention. The results call for increased efforts in describing and detecting patho...... disorders. The objective of this study was to describe pathological eating behaviour, dysfunctional body focusing and psychological symptoms in a sample of childcare residents compared with a non-clinical sample. Sixty-one childcare residents (aged 14?21 years, mean 16.2) and a non-clinical comparison group...

  14. 儿童支气管异物246例临床分析%Clinical analysis of bronchial foreign bodies in 246 children

    Institute of Scientific and Technical Information of China (English)

    马渝燕; 焦安夏; 江沁波; 饶小春; 潘跃娜; 刘玺诚

    2010-01-01

    目的 回顾性研究儿童支气管异物的临床特点以及电子支气管镜在诊断治疗儿童支气管异物中的作用.方法 2000年1月至2009年8月北京儿童医院经支气管镜诊断治疗的支气管异物患儿246例,应用Olympus电子支气管镜,在局部黏膜麻醉下经鼻插入支气管镜逐级观察支气管结构,使用篮状异物钳或齿状异物钳钳取异物.结果 246例患儿中,支气管异物以果仁或果壳类(230例,占93.5%)最为常见,异物嵌顿位置以右下叶支气管开口(98例,占39.8%)为最多.钳取异物手术次数平均为(1.9±1.3)次,一次取出率为58.5%(144例).阻塞于左右主支气管、右中叶和右下叶支气管的异物一次取出率较高,分别为91.1%、60.0%和55.1%.篮状异物钳钳取所需次数(1.4±0.9)明显低于齿状异物钳所需次数(2.1±1.4),差异有统计学意义(P=0.000).结论 儿童支气管异物种类以果仁或果壳类植物性异物为主,阻塞部位以右下支气管为多见.位于左右主支气管异物一次取出率明显高于其他部位.用篮状异物钳钳取异物所需手术次数明显少于使用齿状异物钳.%Objective To analyze the characters of bronchial foreign bodies in children and the utilization of bronchoscope in the treatment of bronchial foreign bodies. Methods A total of 246 children were diagnosed with bronchial foreign bodies at our hospital during January 2000 until August 2009. Under local mucosal anesthesia, a bronchoscope was inserted through nasal cavity into bronchi. After identifying the site of foreign body, grasping forceps was guided through bronchoscope to remove the foreign body from airway. Results Among 246 cases, hard nut and skin of melon seed were found ( n = 230, 93.5% ). The most common site of foreign body was in right lower lobe bronchi ( n =98, 38.9% ). The average operative frequency was 1.9 ± 1.3 and one-time extraction ratio 58.5% ( n = 144). The one-time extraction ratio of patients with foreign

  15. A Czech Morphological Lexicon

    OpenAIRE

    Skoumalova, Hana

    1997-01-01

    In this paper, a treatment of Czech phonological rules in two-level morphology approach is described. First the possible phonological alternations in Czech are listed and then their treatment in a practical application of a Czech morphological lexicon.

  16. Advancement of Molecular Morphology

    Institute of Scientific and Technical Information of China (English)

    顾江

    2004-01-01

    @@ Molecular morphology is a new discipline of medical science that studies morphology at the molecular level. This includes the investigation of occurrence and distribution of proteins, peptides, DNA and RNA sequences at the tissue, cellular, and ultrastructural levels.

  17. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males

    OpenAIRE

    Leutholtz Brian; Redd Liz; Hudson Geoffrey; Buford Thomas; Cooke Matt; Shelmadine Brian; Willoughby Darryn S

    2009-01-01

    Abstract Purpose This study determined the effects of 28 days of heavy resistance exercise combined with the nutritional supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers. Methods Eighteen non-resistance-trained males participated in a resistance training program (3 × 10-RM) 4 times/wk for 28 days while also ingesting 27 g/day of placebo (PL) or NO-Shotgun® (NO) 30 min prior to exercise. Data were analyzed...

  18. R-body-producing bacteria.

    Science.gov (United States)

    Pond, F R; Gibson, I; Lalucat, J; Quackenbush, R L

    1989-03-01

    Until 10 years ago, R bodies were known only as diagnostic features by which endosymbionts of paramecia were identified as kappa particles. They were thought to be limited to the cytoplasm of two species in the Paramecium aurelia species complex. Now, R bodies have been found in free-living bacteria and other Paramecium species. The organisms now known to form R bodies include the cytoplasmic kappa endosymbionts of P. biaurelia and P. tetraurelia, the macronuclear kappa endosymbionts of P. caudatum, Pseudomonas avenae (a free-living plant pathogen), Pseudomonas taeniospiralis (a hydrogen-oxidizing soil microorganism), Rhodospirillum centenum (a photosynthetic bacterium), and a soil bacterium, EPS-5028, which is probably a pseudomonad. R bodies themselves fall into five distinct groups, distinguished by size, the morphology of the R-body ribbons, and the unrolling behavior of wound R bodies. In recent years, the inherent difficulties in studying the organization and assembly of R bodies by the obligate endosymbiont kappa, have been alleviated by cloning and expressing genetic determinants for these R bodies (type 51) in Escherichia coli. Type 51 R-body synthesis requires three low-molecular-mass polypeptides. One of these is modified posttranslationally, giving rise to 12 polypeptide species, which are the major structural subunits of the R body. R bodies are encoded in kappa species by extrachromosomal elements. Type 51 R bodies, produced in Caedibacter taeniospiralis, are encoded by a plasmid, whereas bacteriophage genomes probably control R-body synthesis in other kappa species. However, there is no evidence that either bacteriophages or plasmids are present in P. avenae or P. taeniospiralis. No sequence homology was detected between type 51 R-body-encoding DNA and DNA from any R-body-producing species, except C. varicaedens 1038. The evolutionary relatedness of different types of R bodies remains unknown. PMID:2651865

  19. [Clinical pathology].

    Science.gov (United States)

    Dimitrijević, Jovan

    2006-05-01

    This work describes the basic elements of pathology used in clinical practice. Pathology plays an important role in clinical and scientific work, but only a few areas of pathology will be covered. Although the contribution of oncological and surgical pathology to therapy is the most well known, the cases chosen here will involve infectious pathology, diseases of the kidney and the liver, autoimmune diseases, as well as organ transplantation. Especially important is the description of methods that enable more accurate morphological diagnoses, such as histochemistry, immunohistochemistry, immunofluorescence, and electronic microscopy. Previous experience and joint work with clinical doctors have enabled the definition of significant morphological elements as well as of essential methods of pathohistological diagnosis. Besides, as is often the case, although disease symptoms are difficult to discern and biochemical results do not show significant changes compared to normal values, the results of biopsy come as a surprise to clinical doctors. For example, in virus hepatitis B involving so-called asymptomatic HBsAg carriers, we discovered every morphological form of hepatitis, from minimal lesions to chronic, persistent, and active hepatitis. With hepatitis C, certain morphological lesions point to the etiopathogenesis of this disease and thus help to confirm the diagnosis and to instigate therapy on time. Another significant experience involves kidney biopsies in cases when clinical findings are asymptomatic. Often, in such cases, morphological findings point to glomerulonephritis and glomerulopathy at different stages. Timely and subtle morphological diagnostics offer a more precise explanation for the pathological injury of tissues than other diagnostic methods. In this way, by adopting new methods, the work of pathologists is included more and more in everyday clinical practice. The inclusion of pathologists in a transplantation team makes sure a proper selection of

  20. Distribution-based estimates of minimum clinically important difference in cognition, arm function and lower body function after slow release-fampridine treatment of patients with multiple sclerosis

    DEFF Research Database (Denmark)

    Jensen, H B; Mamoei, Sepehr; Ravnborg, M;

    2016-01-01

    OBJECTIVE: To provide distribution-based estimates of the minimal clinical important difference (MCID) after slow release fampridine treatment on cognition and functional capacity in people with MS (PwMS). METHOD: MCID values were determined after SR-Fampridine treatment in 105 PwMS. Testing...

  1. Whole-body computed tomography

    International Nuclear Information System (INIS)

    The textbook covers all aspects of the modern (spiral) CT methods: The technical principle, evaluation modalities and artefacts, specific diagnostic examinations such as CT angiography, CTAP, CT arthrography, CT-guided biopsy, as well as the principles guiding the analysis of the tomographic images are explained in the initial chapter on fundamentals. Further methodological information is given in the second chapter discussing the various examination strategies, and the value of the material is enhanced by a wealth of diagnostic image reproductions of latest available standard. The chapters devoted to the body organs of interest are arranged by organs and cover information on the normal anatomy, diagnostic examination techniques, contrast agent performance and, as a very important part, the full-detail CT morphology, supplemented by information describing the anatomy, pathophysiology and clinical aspects of relevance to the diagnostic decisions. There are as well many practical hints which readers may find useful in their practical work. Every chapter contains tables summarizing and showing at a glance information on indications, specific examination techniques, including the scan parameters for the spiral CT, and on differential diagnoses. (orig./CB)

  2. Body punk

    DEFF Research Database (Denmark)

    Mogensen, Kevin

    BODYPUNK - A Treatise on male body builders and the meaning of the body in the shadow of an Anti Doping Campaign Based on a qualitative study, the thesis investigates the visual representation of the male bodybuilder found in the national anti doping campaign: ‗ "The hunt has begun" along...... with an analysis of the embodied meaning of men‘s bodybuilding....

  3. Body punk

    DEFF Research Database (Denmark)

    Mogensen, Kevin

    BODYPUNK - A Treatise on male body builders and the meaning of the body in the shadow of an Anti Doping Campaign Based on a qualitative study, the thesis investigates the visual representation of the male bodybuilder found in the national anti doping campaign: ‗ "The hunt has begun" along with an...... analysis of the embodied meaning of men‘s bodybuilding....

  4. Body Language

    Institute of Scientific and Technical Information of China (English)

    JosephDeVeto

    2004-01-01

    When we speak,we use much more than just words. We also communicate with our face. our hands,and even our own body. This Kind of communication ean be called “body language” or “non-verbal eommunieation”. Non-verbal

  5. Body Weight and Body Image

    OpenAIRE

    McFarlane Traci; Olmsted Marion P

    2004-01-01

    Abstract Health Issue Body weight is of physical and psychological importance to Canadian women; it is associated with health status, physical activity, body image, and self-esteem. Although the problems associated with overweight and obesity are indeed serious, there are also problems connected to being underweight. Weight prejudice and the dieting industry intensify body image concerns for Canadian women and can have a major negative impact on self-esteem. Key Findings Women have lower BMIs...

  6. Long term morphological modelling

    DEFF Research Database (Denmark)

    Kristensen, Sten Esbjørn; Deigaard, Rolf; Taaning, Martin;

    2010-01-01

    A morphological modelling concept for long term nearshore morphology is proposed and examples of its application are presented and discussed. The model concept combines parameterised representations of the cross-shore morphology, with a 2DH area model for waves, currents and sediment transport in...

  7. Advancement of Molecular Morphology

    Institute of Scientific and Technical Information of China (English)

    顾江

    2004-01-01

    Molecular morphology is a new discipline of medical science that studies morphology at the molecular level. This includes the investigation of occurrence and distribution of proteins, peptides, DNA and RNA sequences at the tissue, cellular, and uhrastructural levels. Morphology is defined as a field of science investigating the shape,

  8. Clinical value of multi-slice CT in diagnosis of intra-thoracic esophageal injury caused by foreign body%多层螺旋CT诊断胸食管异物损伤的临床价值

    Institute of Scientific and Technical Information of China (English)

    程功文; 魏益平; 王一明; 俞东亮; 江涵; 高华; 徐建军

    2012-01-01

    Objective To investigate the clinical value of MSCT in diagnosis of intra-thoracic esophageal injury caused by foreign body. Methods A total of 22 patients with intra-thoracic esophageal injury caused by foreign body were retrospectively analyzed. All patients underwent MSCT plain scan, 13 of them underwent enhanced scan, and then post-processing techniques were applied. Diagnosis and therapy decision were based on the performance of MSCT and clinical features. Results The coincidence rate was 68. 18% (15/22) and 76. 92% (10/13) of MSCT plain scan and post-processing with treatment results. Combined with clinical characteristics, MSCT accurately diagnosed all injuries. Twenty patients were cured eventually, two patients died. Conclusion MSCT is of great clinical value for the diagnosis of intra-thoracic esophageal in-jury caused by foreign body. Combined with clinical characteristics, MSCT can accurately diagnose and classify intra-thoracic esophageal injury, contributing to the therapy strategy of these lesions.%目的 探讨MSCT诊断胸食管异物损伤的临床价值.方法 22例胸食管异物损伤患者均接受MSCT平扫,其中13例接受增强薄层扫描及后处理成像.依据MSCT特征、结合临床表现决定诊断及治疗方案.结果 MSCT平扫及后处理影像诊断与临床诊断的总符合率分别为68.18%(15/22)和76.92%(10/13),结合临床特征均确诊.22例中,痊愈20例,死亡2例.结论 MSCT是诊断胸食管异物损伤的最具临床价值的影像学方法,结合临床特征可确诊,对制定科学、合理的治疗方案具有指导意义.

  9. Unusual orbital foreign bodies

    Directory of Open Access Journals (Sweden)

    Agarwal P

    1993-01-01

    Full Text Available Retained intraorbital organic foreign bodies, particularly wooden, are commonly encountered in ophthalmologic practice. We treated two children who had sustained such injury while playing. They presented to us with non-healing sinus with purulent discharge. In one of the patients, X-rays and CT scan helped to clinch the diagnosis, whereas in the other patient diagnosis was possible by correlating history with clinical findings. Surgical exploration in both patients helped us to remove the foreign bodies. Surprisingly, both the foreign bodies were 7 cm long wooden pieces. We, however, caution that management of such cases should be conservative and that surgical exploration be done only in case of complication. From our experience, we recommend proper localisation by all possible means, blunt dissection, careful haemostasis coupled with excellent lighting and exposure in the atraumatic removal of intraorbital foreign bodies.

  10. Clinical and biochemical outcomes for additive mesenteric and lower body perfusion during hypothermic circulatory arrest for complex total aortic arch replacement surgery.

    Science.gov (United States)

    Fernandes, P; Cleland, A; Adams, C; Chu, M W A

    2012-11-01

    Surgical repair of transverse aortic arch aneurysms frequently employ hypothermia and antegrade cerebral perfusion as protective strategies during circulatory arrest. However, prolonged mesenteric and lower limb ischemia can lead to significant lactic acidosis and end organ dysfunction, which remains a significant cause of post-operative morbidity and mortality. We report our experience with additive warm mesenteric and lower body perfusion (1-3 L/min, 30°C) in addition to continuous cerebral and myocardial perfusion in 5 patients who underwent total aortic arch replacement with trifurcated head vessel re-implantation and distal elephant trunk reconstruction. Concomitant surgical procedures included re-operations (2), aortic root operations (2), coronary artery bypass (2) and descending thoracic aortic replacement (1). Serum lactate levels demonstrated a rapid decline from a peak 9.9 ± 2.6 post circulatory arrest to 3.4 ± 2.0 in the intensive care unit (ICU). The lowest serum bicarbonate levels were 19.3 ± 3.5 mmol/L, intra-operatively, which normalized to 28.4 ± 2.4 mmol/L on return to the ICU. The lowest pH levels were 7.25 ± 0.10, corrected to 7.43 ± 0.04 on return to the ICU. Mean cardiopulmonary bypass and aortic cross-clamp times were 361 ± 104 and 253 ± 85 minutes, respectively. Mean cerebral and lower body circulatory arrest times were 0 (0) and 50 ± 35 minutes, respectively. The mean time required for systemic rewarming was 95 ± 66 minutes. There were no in-hospital mortalities and no patient experienced any neurological, mesenteric, renal or lower limb ischemic complications. Two patients required mechanical ventilation >24 hours, and one patient returned for reoperation for bleeding. Median intensive care unit and total hospital lengths of stay were 5 and 16 days, respectively. Our results suggest early serum lactate clearance, normalization of acidosis, and metabolic recovery when utilizing a simultaneous cerebral perfusion and warm body

  11. Human body communication performance simulations

    OpenAIRE

    Mufti, H. (Haseeb)

    2016-01-01

    Human Body Communication (HBC) is a novel communication method between devices which use human body as a transmission medium. This idea is mostly based on the concept of wireless biomedical monitoring system. The on-body sensor nodes can monitor vital signs of a human body and use the body as a transmission medium. This technology is convenient for long durations of clinical monitoring with the option of more mobility and freedom for the user. In this thesis, IEEE 802.15.6-2012 phy...

  12. Do generalists and specialists agree on descriptive acne morphology?

    DEFF Research Database (Denmark)

    Yazdanyar, S; Bryld, L E; Heidenheim, M;

    2013-01-01

    BACKGROUND: Acne is a common skin disease, which is treated by many different specialities. Clinical guidelines for treatment are based on the recognition of acne morphology. The assessment of acne morphology is therefore an important element of the proper diagnosis and treatment of acne. OBJECTIVE...... in the distribution of answers. CONCLUSION: GPs described acne morphology recognized clinical hallmarks of severity in acne less well than dermatologists and were far less consistent....

  13. Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.

    Directory of Open Access Journals (Sweden)

    Baoping Zhang

    Full Text Available The adverse effect induced by carbon ion radiation (CIR is still an unavoidable hazard to the treatment object. Thus, evaluation of its adverse effects on the body is a critical problem with respect to radiation therapy. We aimed to investigate the change between the configuration and mechanical properties of erythrocytes induced by radiation and found differences in both the configuration and the mechanical properties with involving in morphological remodeling process. Syrian hamsters were subjected to whole-body irradiation with carbon ion beams (1, 2, 4, and 6 Gy or X-rays (2, 4, 6, and 12 Gy for 3, 14 and 28 days. Erythrocytes in peripheral blood and bone marrow were collected for cytomorphological analysis. The mechanical properties of the erythrocytes were determined using atomic force microscopy, and the expression of the cytoskeletal protein spectrin-α1 was analyzed via western blotting. The results showed that dynamic changes were evident in erythrocytes exposed to different doses of carbon ion beams compared with X-rays and the control (0 Gy. The magnitude of impairment of the cell number and cellular morphology manifested the subtle variation according to the irradiation dose. In particular, the differences in the size, shape and mechanical properties of the erythrocytes were well exhibited. Furthermore, immunoblot data showed that the expression of the cytoskeletal protein spectrin-α1 was changed after irradiation, and there was a common pattern among its substantive characteristics in the irradiated group. Based on these findings, the present study concluded that CIR could induce a change in mechanical properties during morphological remodeling of erythrocytes. According to the unique characteristics of the biomechanical categories, we deduce that changes in cytomorphology and mechanical properties can be measured to evaluate the adverse effects generated by tumor radiotherapy. Additionally, for the first time, the current study

  14. Bog bodies

    DEFF Research Database (Denmark)

    Lynnerup, Niels

    2015-01-01

    the bog bodies have been studied using medical and natural scientific methods, and recently many bog bodies have been re-examined using especially modern, medical imaging techniques. Because of the preservation of soft tissue, especially the skin, it has been possible to determine lesions and trauma...... and shrink, leading to potential pitfalls in paleopathological diagnostics. Bog bodies have in several instances been crucial in determining the last meal, as gut contents may be preserved, and thus augment our knowledge on pre-historic diet by adding to, for example, stable isotope analyses. This article...

  15. 全身弥散加权成像技术进展及其临床应用%Whole-body diffusion-weighted imaging: technical improvement and clinical application

    Institute of Scientific and Technical Information of China (English)

    吴旭; 马常英; 赵霞

    2009-01-01

    Diffusion weighted imaging of entire body is a new promising technique which is feasible to evaluate multi-focal disease. Whole-Body diffusion weighted imaging (WB-DWI) has revealed great potential in the evaluation of both quantitative and qualitative information of the whole body. The technique should be used combined with the other standard sequences such as STIR images. A complete scanning sequence and diffusion weighted imaging (DWI) can be performed in less than 40 min. The feasibility, limitations and the clinical effect of WB-DWI are reviewed.%全身弥散加权成像(WB-DWI)是一种评价全身多发病变的新型影像技术,能对全身病变提供有益的信息,在应用中需要与其他成熟的序列比如STIR相结合.一个完整的扫描序列及合成WB-DWI的总时间在40分钟以内.本文对全身DWI可行性、局限性及初期临床应用效果作如下综述.

  16. SU-C-18C-06: Radiation Dose Reduction in Body Interventional Radiology: Clinical Results Utilizing a New Imaging Acquisition and Processing Platform

    International Nuclear Information System (INIS)

    Purpose: To quantify the patient radiation dose reduction achieved during transarterial chemoembolization (TACE) procedures performed in a body interventional radiology suite equipped with the Philips Allura Clarity imaging acquisition and processing platform, compared to TACE procedures performed in the same suite equipped with the Philips Allura Xper platform. Methods: Total fluoroscopy time, cumulative dose area product, and cumulative air kerma were recorded for the first 25 TACE procedures performed to treat hepatocellular carcinoma (HCC) in a Philips body interventional radiology suite equipped with Philips Allura Clarity. The same data were collected for the prior 85 TACE procedures performed to treat HCC in the same suite equipped with Philips Allura Xper. Mean values from these cohorts were compared using two-tailed t tests. Results: Following installation of the Philips Allura Clarity platform, a 42.8% reduction in mean cumulative dose area product (3033.2 versus 1733.6 mGycm∧2, p < 0.0001) and a 31.2% reduction in mean cumulative air kerma (1445.4 versus 994.2 mGy, p < 0.001) was achieved compared to similar procedures performed in the same suite equipped with the Philips Allura Xper platform. Mean total fluoroscopy time was not significantly different between the two cohorts (1679.3 versus 1791.3 seconds, p = 0.41). Conclusion: This study demonstrates a significant patient radiation dose reduction during TACE procedures performed to treat HCC after a body interventional radiology suite was converted to the Philips Allura Clarity platform from the Philips Allura Xper platform. Future work will focus on evaluation of patient dose reduction in a larger cohort of patients across a broader range of procedures and in specific populations, including obese patients and pediatric patients, and comparison of image quality between the two platforms. Funding for this study was provided by Philips Healthcare, with 5% salary support provided to authors K. Pallav

  17. 全身骨显像诊断肺癌骨转移的临床价值%Clinical value of the whole body bone imaging in diagnosing bone metastasis from lung cancer

    Institute of Scientific and Technical Information of China (English)

    贾莉; 夏正武; 马世兴

    2011-01-01

    Objective: To explore clinical value of the whole body bone imaging in diagnosing bone metastasis from lung cancer, in order to guide staging and treatment of patients with lung cancer. Methods: 126 patients with pathological diagnosis of lung cancer were performed whole body bone imaging, CT and ALP, blood calcium inspection. Probability of bone metastasis from lung cancer of the different pathological type and different clinical stage were counted. The whole body bone imaging and clinical factors of suspicious bone metastasis (including bone pain, alkaline phosphatase, high calcium lev -els, arbitrary or a few) for diagnosis accuracy of bone metastases were statistical compared. Results: The incidence of bone metastasis from lung cancer was 27.8%, and the bone metastases occurrence probability of peripheral lung cancer was higher than central lung cancer (P<0.01), bone metastases occurrence probability of lung adenocarcinoma was higher than lung squamous cell carcinoma (P<0.01), bone metastases occurrence probability of period Ⅲ, IV patients was obviously higher than that of period I , II (P<0.01). The sensitivity (94.3%), specific degrees (84.6%), accuracy (87.3%) of the whole body bone imaging diagnosis of bone metastases from lung cancer were higher than the clinical factors of suspicious bone metas -tasis diagnosis of bone metastases. Conclusion: Whole body bone imaging should be a routine examination in patients with lung cancer. The clinical significance is important to determine stage and treatment of lung cancer.%目的:探讨全身骨显像在诊断肺癌骨转移的临床价值,以便更好地指导肺癌患者的分期及治疗.方法:126例病理确诊为肺癌的患者均行全身骨显像、CT及碱性磷酸酶、血钙检查.统计肺癌患者不同病理类型、不同临床分期发生骨转移的几率,将全身骨显像与可疑骨转移临床因素(包括骨痛、碱性磷酸酶升高、高钙血症中任意一项或几项)诊断骨转移

  18. The Clinical Value of Body Language Communication and Application in Pediatric Nursing Work%肢体语言沟通应用于小儿护理工作的临床价值

    Institute of Scientific and Technical Information of China (English)

    何素平

    2015-01-01

    ObjectiveTo analyze the clinical value of body language communication in nursing work in children.Methods60 pediatric patients in our hospital were selected as the main research object, and were divided into observation group and routine group. On the basis of the observation group to strengthen the body language communication. Comparison of two groups of patients in the treatment of compliance indicators.Results The acceptance rate of the observation group was significantly higher than that of the conventional group, the difference was statisticaly significant (P<0.05). Conclusion On the basis of routine nursing care in pediatric patients, strengthen body language communication, can effectively improve the clinical symptoms of patients, improve patient compliance index.%目的:分析肢体语言沟通应用于小儿护理工作的临床价值。方法选取本院儿科60例小儿患者作为主要的研究对象,分为观察组以及常规组,常规组患者使用常规护理干预。观察组则在上述的基础上强化肢体语言沟通力度。比较两组患者治疗顺应性指标。结果观察组接受率明显高于常规组两组差异显著,具有显著统计学意义(P<0.05)。结论对儿科患者在使用常规护理的基础上强化肢体语言沟通,可以有效的改善患者的临床症状,改善患者顺应性指标。

  19. 初产妇采用分娩球配合自由体位助产的临床经验%Clinical experience of delivery ball with free body position for midwifery of primipara

    Institute of Scientific and Technical Information of China (English)

    唐艳; 冉扬; 张洁

    2015-01-01

    目的:讨论采用分娩球配合自由体位助产作用于初产妇的临床体验。方法:收治初产妇12例,采用分娩球配合自由体位分娩,回顾性分析其临床资料。结果:经过分析,共总结出四个要点,有利于拉近医患关系,增加夫妻之间的感情,提高分娩自我效能以及增加舒适度。结论:对初产妇行分娩球配合自由体位助产,不仅能够大幅度地提高产妇的舒适度和自然分娩信心,还有助于构建和谐的医患关系。%Objective:To explore the clinical experience of delivery ball with free body position for midwifery of primipara. Methods:12 primipara were selected.They were given delivery ball with free body position for midwifery,and clinical data were retrospectively analyzed.Results:Through analysis,we summed up four main points,which were conducive to narrowing the relationship between doctors and patients,increasing the relationship between husband and wife,improving labor efficiency and increasing comfort.Conclusion:Delivery ball with free body position for midwifery was used in primipara,which not only can greatly improve the comfort and natural childbirth confidence,but also help to build a harmonious relationship between doctors and patients.

  20. Clinical evaluation of bone marrow transplantation using total body irradiation and induction chemotherapy. Treatment results during twelve years at our hospital and some problems on the therapy

    Energy Technology Data Exchange (ETDEWEB)

    Kawamura, Toshiki; Koga, Sukehiko; Kikukawa, Kaoru; Okamoto, Masataka; Miyazaki, Hitoshi; Kojima, Hiroshi; Esaki, Kohji [Fujita Health Univ., Toyoake, Aichi (Japan). School of Medicine

    2000-10-01

    We performed sixty patients with hematological malignancies the total body irradiation prior to bone marrow transplantation (TBI-BMT) from 1988 to 2000. We delivered our each patient hyperfractionated TBI consisting of 2 fractions of 3 Gy per day for 2 consecutive days following induction chemotherapy. It proved that TBI-BMT was a valuable treatment method for hematological malignancies which have poor prognosis. About the cumulative survival rate, patients of first remission were better outcome than patients beyond second remission. However, the therapy remained some problems which were the prophylaxis of GVHD for HLA-matched unrelated recipients. And we have to consider a new maintenance procedure to prevent relapse from transplanted donor cell. (author)

  1. Measurement and significance of sperm morphology

    Institute of Scientific and Technical Information of China (English)

    Roelof Menkveld; Cas AG Holleboom; Johann PT Rhemrev

    2011-01-01

    The measurement or evaluation and clinical significance of human sperm morphology has always been and still is a controversial aspect of the semen analysis for the determination of a male's fertility potential.In this review the background of the development of the evaluation criteria for sperm morphology will be discussed.Aspects of criticism on the strict criteria definition and use of the criteria for sperm morphology evaluation will be discussed as well as possible reasons for the decline in normal sperm morphology values and how we can compromise for this phenomenon resulting in the very low normal reference value as published in the 2010 WHO manual for the Examination and Processing of Human Semen.One of the possible solutions may be to give more attention to a limited number of abnormal sperm morphology categories and the inclusion of sperm morphology patterns.It is concluded in this review that if done correctly and with care and with strict application of existing guidelines as outlined in the 2010 WHO manual,sperm morphology measurement still has a very important role to play in the clinical evaluation of male fertility potential.

  2. 恶性肿瘤骨髓转移的形态学检验与临床特点分析%Morphological examination and clinical characteristics analysis of transfer of bone marrow in ma-lignant tumor

    Institute of Scientific and Technical Information of China (English)

    张颜粉

    2016-01-01

    Objective To study the morphological examination and clinical characteristics analy-sis of transfer of bone marrow in malignant tumor. Methods From May 2010 to May 2014, fourty pa-tients with transfer of bone marrow in malignant tumor were selected. Living tissue and bone marrow smears were detected, the clinical characteristics were analyzed. Results Fourty patients with malignant tumors were all taken the examination of smear of bone marrow. There were 34 cases, accounting for 85%. There were 6 cases of bone marrow biopsy, the positive rate was 83. 3%. Among 6 cases of nega-tive smears, 3 cases of bone marrow hyperplasia, but their living tissue hyperplasia was hyperactive, parts of fibrous tissue had hyperplasia. It showed that small sludged blood in puncture needle or may be diluted when pumping, which can influent the smear quality. Among other 3 cases, dry tap appeared be-cause sclerotin was too hard when inserting needles, there was a few number of nucleated cells in the smears. Six negative cases were diagnosed by biopsy whose effects were ideal. Because one specimen was lesser, one case of negative specimen had effects on diagnosis. Conclusions Bone marrow is treated as common transfer parts of malignant tumor clinically. Synchronous double samples of biopsy and bone mar-row smear have higher positive rates, and results have a complementary effect between them.%目的:探讨恶性肿瘤骨髓转移的形态学检验与临床特点。方法选取济源市人民医院血液科2010年5月至2014年5月收治的恶性肿瘤骨髓转移患者40例,均行活组织和骨髓涂片检查,并分析其临床特点。结果40例恶性肿瘤骨髓转移患者均行骨髓涂片检查,阳性34例,占85%。骨髓活组织检查6例,阳性率为83.3%。涂片检查6例阴性中,3例骨髓增生低下,但其活组织增生极度活跃,纤维组织部分增生,表明穿刺针中有小凝血块或抽吸时可能稀释,对涂片质量有影响;另3例在进针时骨质

  3. Body Language

    Institute of Scientific and Technical Information of China (English)

    王芳

    2008-01-01

    @@ For Teachers: The Wordless Language Spoken by Everyone by Pamela Osment An old saying goes:"Actions speak louder than words."That's true according to communication experts.Some studies show that up to 90 percent of communication is nonverbal.Though you might say one thing,your body movements may indicate something entirely different.This nonverbal way of communicating is called body language.The Universal(通用的)Language

  4. [Location of disease: acupoint view from the angle of clinic].

    Science.gov (United States)

    Zhang, Jian-Bin; Zou, Yang-Yang; Hu, Guang-Yong; Wu, Jiu-Long; Bai, Jie-Jing; Zhang, Shu-Jian

    2014-12-01

    Doctor WANG Zhi-zhong in the Southern Song Dynasty proposed the acupoint view of "location of disease", which explained the connotation of acupoints from the angle of clinic. Its meaning included two levels, one level meant pathological change on the body surface, that was the location of acupuncture diagnosis-treatment, and the other one indicated that the body surface which was the reflecting point of pathological change on the distal area or inside the body was the location of acupuncture diagnosis-treatment. The specific connotations of clinical acupoints were: location of pathogenic factors or reflection of pathogenic factors, regularity between acupoints un- der disease and specific organ, morphological differences and positioning variability after acupoints under disease, and acupoints examination, diagnosis and treatment. PMID:25876353

  5. Aspectos clínicos e funcionais do equilíbrio corporal em idosos com vertigem posicional paroxística benigna Clinical and functional aspects of body balance in elderly subjects with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Daniela Patricia Vaz

    2013-04-01

    Full Text Available Vertigem Posicional Paroxística Benigna (VPPB pode alterar o equilíbrio corporal em pacientes idosos. OBJETIVO: Observar os efeitos da manobra de Epley em idosos com VPPB, avaliando os aspectos clínicos e funcionais do equilíbrio corporal. Forma de estudo: clínico e prospectivo. MÉTODO: Após o diagnóstico da doença (teste de DixHallpike, os testes Time Up and Go (TUGT, Clinical test of Sensory Interaction and Balance (CTSIB e o teste de membros inferiores (MMI foram realizados antes e após a manobra de reposicionamento de Epley modificada. RESULTADOS: O gênero feminino foi o mais prevalente e a média etária foi de 70,10 anos (DP = 7,00. Todos os pacientes apresentaram ductolitíase de canal posterior. Os seguintes sintomas melhoraram após a manobra: a instabilidade postural (p = 0,006, náusea e vômito (p = 0,021 e zumbido (p = 0,003. Em relação ao TUGT e o escore do teste de MMII, observou-se diminuição significante do tempo pós-manobra de Epley (p Benign paroxysmal positional vertigo (BPPV may compromise the balance of elderly subjects. OBJECTIVE: To observe the effects of the Epley maneuver in elderly subjects with BPPV and assess clinical and functional aspects of body balance. METHOD: This is a prospective clinical study. Patients diagnosed with BPPV (Dix-Hallpike test were submitted to the Timed Up & Go (TUG test, the Clinical Test of Sensory Interaction and Balance (CTSIB, and lower limb testing before and after they were repositioned using the modified Epley maneuver. RESULTS: Most subjects were females, and the group's mean age was 70.10 years (SD = 7.00. All patients had canalithiasis of the posterior canal. The following symptoms improved after the maneuver: postural instability (p = 0.006, nausea and vomiting (p = 0.021, and tinnitus (p = 0.003. Subjects improved their times significantly in the TUG and lower limb tests after the Epley maneuver (p < 0.001. Patients performed better on the CTSIB after the Epley

  6. Body contact and body language

    DEFF Research Database (Denmark)

    Winther, Helle Dagmar

    2008-01-01

    ­ment psychology and education provide potential for intense personal develop­ment as well as for social and cultural learning processes. This performative research project originates from the research project entitled, Movement Psy­chol­ogy: The Language of the Body and the Psy­chol­ogy of Movement based...... on the Dance Therapy Form Dansergia. The author, who is a practi­tioner-researcher, is methodologically inspir­ed by phenomenology, performative methods and a narrative and auto-ethnographic approach. The project will be presented in an organic, cre­at­ive and performative way. Through a moving dia......Body contact and body language are unique and existential and, although culturally dependent and socially embodied, they are also universal communication forms. For small children all over the world, warm, close and nourishing body contact is fundamental to their embodied experi­ence of themselves...

  7. A prospective study of the early clinical symptoms following a 2 Gy therapeutic whole-body irradiation; Etude prospective de la symptomatologie clinique precoce apres irradiation corporelle totale therapeutique de 2 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Fizazi, K.; Chaillet, M.P.; Fourquet, A.; Jammet, P.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

    1995-10-01

    Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospectively evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16*61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injected intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69%), headache (62%), xerostomia (62%), nausea and vomiting (46%), anorexia (38%), parotid gland pain (23%) and abdominal pain (8%). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irradiation. In particular, absence of fever at the 6{sup th} h after TBI supports the assumption of an estimated exposure dose below 2 Gy. (authors). 23 refs., 2 tabs.

  8. Esophageal Foreign Bodies

    Directory of Open Access Journals (Sweden)

    Ufuk Cobanoglu

    2014-04-01

    Full Text Available Esophageal foreign body aspiration is a common event which can cause serious morbidity and mortality in the children and adult population. For that reason, early diagnosis and treatment are crucial for preventing these life threateining complications. Children most often ingest coins and toys whereas adults commonly tend to have problems with meat and bones. Esophageal foreign bodies are located at the cricopharyngeus muscle level in 70%, the thoracic esophagus in 15% and the gastroesophageal junction in the remaining 15%. Symptoms can vary according to the shape and structure of the ingested object, type of location, patient%u2019s age and complications caused by the foreign body. Delay in treatment, esophageal perforation and an underlying esophageal disease are poor prognostic factors. In treatment, observation, foley catheter, rigid or flexible esophagoscopy and removing the foreign body with a Magill forceps, pushing the foreign body into the stomach, giving intravenous glucagon and surgical treatment methods can be used. Rigid esophagoscopy is an effective and safe procedure for foreign body diagnosis and removal. Improved endoscopic experience and clinical management of thoracic surgeons led to reduced morbidity and mortality in recent years. Most of those emergencies of childhood are preventable. Family education is very important.

  9. Effects of L- Arginine Supplementation on Antioxidant Status and Body Composition in Obese Patients with Pre-diabetes: A Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Siavash Fazelian

    2014-10-01

    Full Text Available Purpose: The aim of present study was to determine effects of L-Arginine supplementation on antioxidant status and body composition in obese patients with prediabetes. Methods: A double-blind randomized control trial was performed on 46 (24 men, 22 women obese patients with prediabetes. They were divided randomly into two groups. Patients in intervention (n = 23 and control group (n=23 received 3 gr/day L-arginine and placebo, respectively for 8 weeks. Anthropometric indices, dietary intake and biochemical measurements ((serum total antioxidant capacity (TAC, Glutathione Peroxidase (GPx and Superoxide Dismutase (SOD were performed at the baseline and after 8-week intervention. Results: The mean age and BMI of participants were 44.29±8.65 years old and 28.14±1.35 kg/m2, respectively. At the end of study, in both intervention and control group, percentage of carbohydrate decreased and %fat intake increased compared to the baseline (P0.05. Among measured biochemical factors, only serum TAC level showed significant differences at the end of study in the intervention group compared to the control group (pv<0.01. Conclusion: 3gr/day L-Arginine supplementation increased TAC level in obese patients with prediabetes.

  10. 颈动脉分叉高度的超声测量及其与体重指数、颈内动脉形态变异的关系%The height of the carotid bifurcation measured by doppler ultrasonography and its relationship with body mass index and morphological variations of the internal carotid arteries

    Institute of Scientific and Technical Information of China (English)

    余琛; 熊建群; 李应华

    2013-01-01

    目的 探讨成人颈动脉分叉高度的超声测量与体重指数、颈内动脉形态变异的关系.方法 联合高、低频超声前瞻性检查728例受试者的双侧颈动脉,按照Wain的方法测量颈动脉分又高度及进行颈内动脉形态分型,分析颈动脉分叉高度与体重指数、颈内动脉形态变异发生率的关系.结果 体重指数≤24时,高位分叉占14.8% (149/1010),>24时占17.5%(78/446),两者差异无统计学意义(P>0.05).在高位分叉组中,颈内动脉形态变异发生率约41.4% (94/227),而正常分叉组中颈内动脉形态变异发生率约27.4% (335/1221,P<0.05),颈内动脉形态变异发生率与分叉高度呈正相关.结论 双侧颈动脉分叉高度与体重指数无显著相关,与形态变异相关.%Objective To explore relationship among the height of carotid bifurcation measured by duplex ultrasonography,body mass index (BMI) and morphological variations of the internal carotid arteries (ICA).Methods 728 subjects were examined by combination of high-and low-frequency ultrasonography.The height of carotid bifurcation was measured and morphological variations of the ICA were classified prospectively according to the criteria by Wain.Relationship among the height of carotid bifurcation,BMI,and morphological variations of the ICA were analyzed statistically.Results High bifurcation (≤ 1.5 cm) was not significantly (P> 0.05)different with BM1 below 24 (14.8%,149/1010)from that with BMI above 24 (17.5%,78/446).The prevalence of morphological variations of the ICA (41.4%,94/227) was significantly higher (P < 0.05) in subjects with high carotid bifurcation than normal subjects (27.4%,335/1221).There was positive correlation between morphological variation of ICA and height of carotid bifurcation.Conclusions There is positive correlation between high carotid bifurcation and morphological variations of the ICA without correlation with BMI.

  11. CLINICAL AND FUNCTIONAL FEATURES OF PANCREAS STATE IN RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    O. O. Basieva

    2000-01-01

    Full Text Available Aim of study: complex pancreas study in rheumatoid arthritis (RA. Material and methods: 120 RA pts were examined clinically Pancreas US-and biochemical study (level of a-amylase and lipase of blood serum by kinetic-calorimetric method was performed in this grouh. Results: 50.8% of pts demonstrated increase of pancreas echo, in 23.3%- widened Wirsung s duct, in 45%- single small focal indurations, more often in the body and cauda pancreatis. Decrease of lipolitic and amylolytic pancreas activity is characteristic for RA, especially in systemic process and long-term disease. Clinical and functional disturbances are connected with morphological changes.

  12. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males

    Directory of Open Access Journals (Sweden)

    Leutholtz Brian

    2009-08-01

    Full Text Available Abstract Purpose This study determined the effects of 28 days of heavy resistance exercise combined with the nutritional supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers. Methods Eighteen non-resistance-trained males participated in a resistance training program (3 × 10-RM 4 times/wk for 28 days while also ingesting 27 g/day of placebo (PL or NO-Shotgun® (NO 30 min prior to exercise. Data were analyzed with separate 2 × 2 ANOVA and t-tests (p Results Total body mass was increased in both groups (p = 0.001, but without any significant increases in total body water (p = 0.77. No significant changes occurred with fat mass (p = 0.62; however fat-free mass did increase with training (p = 0.001, and NO was significantly greater than PL (p = 0.001. Bench press strength for NO was significantly greater than PL (p = 0.003. Myofibrillar protein increased with training (p = 0.001, with NO being significantly greater than PL (p = 0.019. Serum IGF-1 (p = 0.046 and HGF (p = 0.06 were significantly increased with training and for NO HGF was greater than PL (p = 0.002. Muscle phosphorylated c-met was increased with training for both groups (p = 0.019. Total DNA was increased in both groups (p = 0.006, while NO was significantly greater than PL (p = 0.038. For DNA/protein, PL was decreased and NO was not changed (p = 0.014. All of the myogenic regulatory factors were increased with training; however, NO was shown to be significantly greater than PL for Myo-D (p = 0.008 and MRF-4 (p = 0.022. No significant differences were located for any of the whole blood and serum clinical chemistry markers (p > 0.05. Conclusion When combined with heavy resistance training for 28 days, NO-Shotgun® is not associated with any negative side effects, nor does it abnormally impact any of the clinical chemistry markers. Rather, NO-Shotgun® effectively increases muscle strength and mass

  13. 106例骨髓转移癌临床及细胞形态学特点分析%Analysis of clinical and cell morphology features in 106 patients with metastatic carcinoma of bone marrow

    Institute of Scientific and Technical Information of China (English)

    陈朴; 王蓓丽; 郭玮; 潘柏申

    2013-01-01

    Objective To investigate the clinical and cell morphology features of metastatic carcinoma of bone marrow.Methods A total of 106 patients with metastatic carcinoma of bone marrow diagnosed were enrolled.The bone marrow and peripheral blood smear cytological characteristics,blood biochemical parameters and clinical manifestations were retrospectively analyzed.Results Osteodynia was the most common symptom.Hematological abnormalities included anemia and thrombocytopenia.The presences of immature erythrocyte and immature granulocyte in peripheral blood smear were demonstrated in 74% of the patients,and 46% of the patients had a dry pumping phenomenon undergoing bone marrow puncture.Metastatic carcinoma cells could be found as a single or formed group or cluster in the bone marrow smears in all 106 patients.Serum alkaline phosphatase and lactate dehydrogenase levels increased in 67%and 69% of the patients,respectively.Carcinomas of unknown origin accounted for 47%,followed by gastric cancer (14%),breast cancer (11%) and prostate cancer (9%).Conclusions The possibility of metastatic carcinoma of bone marrow should be considered,if the symptoms include unexplained anemia,fever,hcmorrhage and osteodynia,with increasing alkaline phosphatase and lactate dehydrogenase,the presences of immature erythrocyte and immature granulocyte in peripheral blood smear.The bone marrow puncture is a simple and valuable method for the diagnosis of metastatic carcinoma of bone marrow.%目的 探讨骨髓转移癌患者的细胞形态学及临床特征.方法 收集106例确诊的骨髓转移癌患者,对其骨髓象、周围血象、血液生化指标及临床特点进行回顾性分析.结果 临床上最常见症状为骨痛;常见血象异常包括贫血、血小板减少,74%患者周围血出现幼粒细胞、幼红细胞;46%的患者骨髓穿刺时有干抽现象.106例患者髓象中均可找到单个或成团、成簇出现的转移癌细胞.血清碱性磷酸

  14. Body Imaging

    Science.gov (United States)

    2001-01-01

    The high-tech art of digital signal processing (DSP) was pioneered at NASA's Jet Propulsion Laboratory (JPL) in the mid-1960s for use in the Apollo Lunar Landing Program. Designed to computer enhance pictures of the Moon, this technology became the basis for the Landsat Earth resources satellites and subsequently has been incorporated into a broad range of Earthbound medical and diagnostic tools. DSP is employed in advanced body imaging techniques including Computer-Aided Tomography, also known as CT and CATScan, and Magnetic Resonance Imaging (MRI). CT images are collected by irradiating a thin slice of the body with a fan-shaped x-ray beam from a number of directions around the body's perimeter. A tomographic (slice-like) picture is reconstructed from these multiple views by a computer. MRI employs a magnetic field and radio waves, rather than x-rays, to create images.

  15. Morphological aspects of radiation injury

    International Nuclear Information System (INIS)

    The injury to haemopoietic and lymphatic tissues produced by ionizing irradiation in various species of mammals including man is one of the major features of the biological effects of radiation (Bond et al. 1965,' Cottier, 1961). At the moment of injury and for a short time thereafter relatively little morphological evidence of cell damage in bone marrow other than cessation of cell division and DNA synthesis is seen. Within a few hours, however, depending on the level of exposure, major destruction of red bone marrow tissue can occur. In this chapter the histologic changes in bone marrow are summarized for correlation with the functional aspects of the change in the target tissue, particularly its cell renewal features and where possible the remarkable flux or migration of cells through bone marrow and lymphatic tissues. This latter topic of cellular traffic represents the outcome of extensive physiological studies on haemopoiesis and lymphopoiesis by mammalian radiobiologists. The initial injury, the structural changes and the physiological consequences are the first half of the radiation injury sequence. Regeneration also has morphological features of major importance to the understanding of radiation haematology. It is common to discuss radiation effects on biological materials from the point of view of external or internal sources of exposure. In addition exposure rate, whole body or partial body, type and quality of the ionizing source are features that must be taken into account. While these features are extremely important, the simplest approach to understanding histologic effects on the bone marrow is to assume acute penetrating whole-body exposure in the lethal range. With this background the differences related to variations in the conditions of exposure can usually be understood. The individual human or animal organism receiving the exposure must also be considered in the final outcome of the experience because age, sex, nutritional status and presence

  16. Pain Flare Is a Common Adverse Event in Steroid-Naïve Patients After Spine Stereotactic Body Radiation Therapy: A Prospective Clinical Trial

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Andrew [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON (Canada); Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON (Canada); Zeng, Liang; Zhang, Liying; Lochray, Fiona; Korol, Renee; Loblaw, Andrew; Chow, Edward [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON (Canada); Sahgal, Arjun, E-mail: arjun.sahgal@sunnybrook.ca [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON (Canada); Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON (Canada)

    2013-07-15

    Purpose: To determine the incidence of pain flare after spine stereotactic body radiation therapy (SBRT) in steroid-naïve patients and identify predictive factors. Methods and Materials: Forty-one patients were treated with spine SBRT between February 2010 and April 2012. All patients had their pain assessed at baseline, during, and for 10 days after SBRT using the Brief Pain Inventory. All pain medications were recorded daily and narcotics converted to an oral morphine equivalent dose. Pain flare was defined as a 2-point increase in worst pain score as compared with baseline with no decrease in analgesic intake, a 25% increase in analgesic intake as compared with baseline with no decrease in worst pain score, or if corticosteroids were initiated at any point during or after SBRT because of pain. Results: The median age and Karnofsky performance status were 57.5 years (range, 27-80 years) and 80 (range, 50-100), respectively. Eighteen patients were treated with 20-24 Gy in a single fraction, whereas 23 patients were treated with 24-35 Gy in 2-5 fractions. Pain flare was observed in 68.3% of patients (28 of 41), most commonly on day 1 after SBRT (29%, 8 of 28). Multivariate analysis identified a higher Karnofsky performance status (P=.02) and cervical (P=.049) or lumbar (P=.02) locations as significant predictors of pain flare. In those rescued with dexamethasone, a significant decrease in pain scores over time was subsequently observed (P<.0001). Conclusions: Pain flare is a common adverse event after spine SBRT and occurs most commonly the day after treatment completion. Patients should be appropriately consented for this adverse event.

  17. No Clinically Significant Changes in Pulmonary Function Following Stereotactic Body Radiation Therapy for Early- Stage Peripheral Non-Small Cell Lung Cancer: An Analysis of RTOG 0236

    Energy Technology Data Exchange (ETDEWEB)

    Stanic, Sinisa, E-mail: sinisa.stanic@carle.com [Carle Cancer Center and University of Illinois College of Medicine, Urbana, Illinois (United States); Paulus, Rebecca [Radiation Therapy Oncology Group Statistical Center, Philadelphia, Pennsylvania (United States); Timmerman, Robert D. [University of Texas Southwestern, Dallas, Texas (United States); Michalski, Jeff M. [Washington University, St. Louis, Missouri (United States); Barriger, Robert B. [Indiana University, Indianapolis, Indiana (United States); Bezjak, Andrea [Princess Margaret Cancer Center, Toronto, Ontario (Canada); Videtic, Gregory M.M. [Cleveland Clinic Foundation, Cleveland, Ohio (United States); Bradley, Jeffrey [Washington University, St. Louis, Missouri (United States)

    2014-04-01

    Purpose: To investigate pulmonary function test (PFT) results and arterial blood gas changes (complete PFT) following stereotactic body radiation therapy (SBRT) and to see whether baseline PFT correlates with lung toxicity and overall survival in medically inoperable patients receiving SBRT for early stage, peripheral, non-small cell lung cancer (NSCLC). Methods and Materials: During the 2-year follow-up, PFT data were collected for patients with T1-T2N0M0 peripheral NSCLC who received effectively 18 Gy × 3 in a phase 2 North American multicenter study (Radiation Therapy Oncology Group [RTOG] protocol 0236). Pulmonary toxicity was graded by using the RTOG SBRT pulmonary toxicity scale. Paired Wilcoxon signed rank test, logistic regression model, and Kaplan-Meier method were used for statistical analysis. Results: At 2 years, mean percentage predicted forced expiratory volume in the first second and diffusing capacity for carbon monoxide declines were 5.8% and 6.3%, respectively, with minimal changes in arterial blood gases and no significant decline in oxygen saturation. Baseline PFT was not predictive of any pulmonary toxicity following SBRT. Whole-lung V5 (the percentage of normal lung tissue receiving 5 Gy), V10, V20, and mean dose to the whole lung were almost identical between patients who developed pneumonitis and patients who were pneumonitis-free. Poor baseline PFT did not predict decreased overall survival. Patients with poor baseline PFT as the reason for medical inoperability had higher median and overall survival rates than patients with normal baseline PFT values but with cardiac morbidity. Conclusions: Poor baseline PFT did not appear to predict pulmonary toxicity or decreased overall survival after SBRT in this medically inoperable population. Poor baseline PFT alone should not be used to exclude patients with early stage lung cancer from treatment with SBRT.

  18. Body Rainbow

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Phubu did not know how long hehad walked after leaving Baxoi, buthe did know that he was halfwaybetween home and Lhasa. Feelingthe weight of the sack containingPhumo's body on his back, Fhubuhad calmed down from the grief anddesperation. He had just one wish:to carry Phumo to Lhasa. He knewthat Phumo had gone, and her soulwas no longer in this body. But hewas determined to finish the trip, notonly because he had promised so, butalso that he believed that it would beredemption for him.

  19. Marijuana and Body Weight

    OpenAIRE

    Sansone, Randy A.; Sansone, Lori A.

    2014-01-01

    Acute marijuana use is classically associated with snacking behavior (colloquially referred to as “the munchies”). In support of these acute appetite-enhancing effects, several authorities report that marijuana may increase body mass index in patients suffering from human immunodeficiency virus and cancer. However, for these medical conditions, while appetite may be stimulated, some studies indicate that weight gain is not always clinically meaningful. In addition, in a study of cancer patien...

  20. [Neuroanatomy of Isolated Body Lateropulsion].

    Science.gov (United States)

    Nakazato, Yoshihiko; Tamura, Naotoshi; Ikeda, Kei; Tanaka, Ai; Yamamoto, Toshimasa

    2016-03-01

    Axial body lateropulsion, a phenomenon where the body is pulled toward the side of the lesion, with tendency of falling down, is the well-known transient feature of lateral medullary syndrome. In some cases, axial body lateropulsion occurs without vestibular and cerebellar symptoms (isolated body lateropulsion:[iBL]). Patients with iBL have a lesion located in the spinocerebellar tract, descending lateral vestibulospinal tract, vestibulo-thalamic pathway, dentatorubrothalamic pathway, or thalamocortical fascicle. This review deals with the anatomic basis and clinical significance of iBL. PMID:27001775

  1. Aspiração de corpo estranho em crianças: aspectos clínicos, radiológicos e tratamento broncoscópico Foreign body aspiration in children: clinical aspects, radiological aspects and bronchoscopic treatment

    Directory of Open Access Journals (Sweden)

    Andrea de Melo Alexandre Fraga

    2008-02-01

    Full Text Available OBJETIVO: Descrever manifestações clínicas e tratamento broncoscópico da aspiração de corpo estranho em crianças menores de 14 anos de idade, correlacionando com achados broncoscópicos. MÉTODOS: Estudo retrospectivo, descritivo analisando prontuários de todas as crianças menores de 14 anos de idade atendidas no Hospital das Clinicas da Universidade Estadual de Campinas de janeiro de 2000 a dezembro de 2005, submetidas à broncoscopia por suspeita clínica de aspiração de corpo estranho. RESULTADOS: Foram analisados 69 pacientes, com idade entre 8 meses e 12 anos/7 meses (75,4% abaixo de 3 anos, dos quais 62,3% eram do sexo masculino. A principal queixa foi tosse súbita (75,4%. Em 74% dos casos houve alteração de ausculta pulmonar e dispnéia foi observada em 20 crianças (29%. Um total de 88% apresentou alteração radiológica. A aspiração ocorreu predominantemente em pulmão direito (54,8%, com material de origem vegetal, destacando feijão e amendoim (30,7%. Complicações ocorreram em 29% dos pacientes, sendo pneumonia a mais comum, e foram associadas ao tempo maior de aspiração (p = 0,03. Um total de 7 pacientes (10,1% necessitaram ventilação mecânica, e 5 (7,2% foram submetidos a mais de uma broncoscopia. CONCLUSÃO: História clínica com início súbito de engasgo e tosse, anormalidades na ausculta pulmonar e na radiografia de tórax caracterizam o quadro clínico de aspiração e são indicativas de broncoscopia. Quanto maior o tempo de aspiração, maior o risco de complicações. A alta prevalência de corpos estranhos de origem vegetal alerta para a necessidade de programas preventivos dirigidos aos menores de 3 anos.OBJECTIVE: To describe the clinical manifestations and bronchoscopic treatment of foreign body aspiration in children under 14 years of age, correlating the clinical aspects with the bronchoscopic findings. METHODS: A retrospective, descriptive study analyzing data related to children under 14

  2. 角膜浅表铁质异物的临床分期和治疗方法%Clinical phases and treatment of corneal superficial iron foreign bodies

    Institute of Scientific and Technical Information of China (English)

    刘安廷; 丁敬军

    2011-01-01

    Objective To study the clinical phases and treatment of corneal superficial iron foreign bodies (CSIFBs).Methods Designating the phases and treatment according to the clinical manifestations of CSIFBs.Results The clinical phases of CSIFBs could be separated into 4 phases as adherence phase,rusterosion phase,exclusion phase and necrotic tissues residue phase and 2 complications as concurrence inflammations and infection.To remove foreign bodies and rust-eaten ring by different techniques in each phase.Conclusion CSIFBs can be designated phases based on diverse clinical manifestations.Applying different techniques can minimize damage and scarring.It is recommended that the treatment should be postponed to exclusion phase or performed by several times,when there is neither concurrence inflammation nor infection.%目的 探讨角膜浅表铁质异物的临床分期和各期治疗方法.方法 根据角膜浅表铁质异物临床表现进行分期,设计各期的治疗方法.结果 角膜浅表铁质异物可分为粘附期、锈蚀期、排异期和坏死组织残留期等4期以及并发炎症反应和并发感染等2种并发症.各期需采用不同方法摘出异物和锈蚀组织.结论 角膜浅表铁质异物可根据其临床表现分期,再采用相应方法摘出异物,能有效减少损伤和瘢痕形成.建议在未发生角膜虹膜反应和感染者可以考虑延后至排异期治疗或分期摘出,以减少瘢痕形成.

  3. Prediction of clinical outcome after stereotactic body radiotherapy for non-small cell lung cancer using diffusion-weighted MRI and {sup 18}F-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Iizuka, Yusuke [Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Matsuo, Yukinori, E-mail: ymatsuo@kuhp.kyoto-u.ac.jp [Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Umeoka, Shigeaki; Nakamoto, Yuji [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Ueki, Nami; Mizowaki, Takashi [Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Togashi, Kaori [Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto (Japan); Hiraoka, Masahiro [Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto (Japan)

    2014-11-15

    Highlights: • We evaluated DW-MRI and FDG-PET as prognostic factor for NSCLC treated with SBRT. • Lower ADC value was relevant to disease progression after SBRT. • Higher SUV{sub max} was relevant to disease progression after SBRT. • Using both values in combination was a better predictor. - Abstract: Purpose/objectives: To evaluate the use of diffusion-weighted magnetic resonance imaging (DW-MRI) and {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for predicting disease progression (DP) among patients with non-small cell lung carcinoma (NSCLC) treated with stereotactic body radiotherapy (SBRT). Materials/methods: Fifteen patients with histologically confirmed stage I NSCLC who underwent pre-treatment DW-MRI and PET and were treated with SBRT were enrolled. The mean apparent diffusion coefficient (ADC) value and maximum standardised uptake value (SUV{sub max}) were measured at the target lesion and evaluated for correlations with DP. Results: The median pre-treatment ADC value was 1.04 × 10{sup −3} (range 0.83–1.29 × 10{sup −3}) mm{sup 2}/s, and the median pre-treatment SUV{sub max} was 9.9 (range 1.6–30). There was no correlation between the ADC value and SUV{sub max}. The group with the lower ADC value (≤1.05 × 10{sup −3} mm{sup 2}/s) and that with a higher SUV{sub max} (≥7.9) tended to have poor DP, but neither trend was statistically significant (p = 0.09 and 0.32, respectively). The combination of the ADC value and SUV{sub max} was a statistically significant predictor of DP (p = 0.036). Conclusion: A low ADC value on pre-treatment DW-MRI and a high SUV{sub max} may be associated with poor DP in NSCLC patients treated with SBRT. Using both values in combination was a better predictor.

  4. Susceptible Bodies

    DEFF Research Database (Denmark)

    Grünenberg, Kristina

    2014-01-01

    is understood as ‘susceptible bodies’ by acupuncturists and reflexologists, are brought into being through various bodily and narrative practices. From a practitioners’ perspective, these practices potentially influence treatment outcomes and enables the emergence of not just new bodies, but also potentially...

  5. Comparison of Clinical and Laboratory Responses in Sheep and Dogs following Whole-Body Exposures to 250-Kvp X-Rays and Fission-Spectrum Neutrons

    International Nuclear Information System (INIS)

    Fifteen sheep and eight dogs were exposed to 400 rad (air dose) of pulsed fission-spectrum neutrons, and an equal number of sheep and 14 dogs to 400 r (midline air dose) 250 kVp X-rays. Seven additional sheep and four dogs served as un-irradiated controls. Control data were obtained for two weeks preceding the exposures and at frequent and regular intervals after the injury. In sheep, the most consistent clinical change was complete loss of wool by the 51st day post-exposure. The underlying skin was pink in colour closely resembling that of a mild blush sometimes noted in humans. Dogs did not demonstrate loss of hair. Formed blood elements, neutrophils, lymphocytes, and thrombocytes fell rapidly after the radiation in both species. At about post-exposure day 24 recovery in white cell numbers was noted only in the neutron groups. Thrombocyte levels decreased to safe level in both species but somewhat earlier in the dog. Recovery appeared during the third post-exposure week in both species ex posed to neutrons, but not in those given X-rays. Red blood-cell haematocrits showed significant drops in both groups of dogs by the ninth day, but neither group of sheep exhibited significant decrease in haematocrit values. Plasma Fe59 clearance rates were determined in the experimental subjects as a parameter of measurement of haematopoietic function. Prognostic implications of alteration in this parameter of haemapoiesis are discussed. The most significant gross-pathologic changes were confined to the lungs wherein extensive perivascular haemorrhage around the arteries was noted. On microscopic study the area of haemorrhage was observed to be within the advential-connective tissue and periarterial vessels. Thirty-day mortality for dogs was 50% following neutron exposures and 93% after the X-ray insult. In sheep neutrons produced 22% mortality and X-rays 80%. (author)

  6. 21 CFR 900.4 - Standards for accreditation bodies.

    Science.gov (United States)

    2010-04-01

    ... image quality, or upon request by FDA, the accreditation body shall review a facility's clinical images... review by the accreditation body demonstrates that a problem does exist with respect to image quality or... accreditation body shall review clinical images from each facility accredited by the body at least once every...

  7. Effects of simulated weightlessness on Nissl body morphology and GDNF in DRG of male rats%模拟失重对雄性大鼠背根神经节尼氏小体形态和胶质细胞源性神经营养因子的影响

    Institute of Scientific and Technical Information of China (English)

    任宁涛; 崔赓; 张恒; 李洁; 雷伟; 刘宁; 毕龙; 吴子祥; 张然; 张永刚

    2015-01-01

    Objective To investigate the effect of simulated weightlessness on dorsal root ganglia (DRG) and GDNF in rat model. Methods Eighty male Sprague-Dawley rats were randomly divided into HU group (n=40) and normal control (NC) group (n=40). The experiment lasted for 4 weeks, then L5 DRG was excised, toluidine blue staining was used to detect the changes of nissl body morphology, and GDNF was detected using immunohistochemistry method. GDNF protein expression was measured by Western-blot and GDNF mRNA expression was measured by RT-PCR.Results Nissl body staining showed that, compared with NC group, nissl bodies were stained light, smaller and scattering distribution in HU group. Immunohistochemistry revealed that the number of GDNF and IOD value reduced significantly in HU group (P<0.05). Western-blot showed that GDNF protein expression in HU group were significantly lower than NC group (P<0.05). mRNA expression of GDNF decreased significantly in HU group (P<0.05). Conclusion Four weeks of stimulated weightlessness can cause damaged changes in DRG nissl body morphology and reduction of the number, protein expression and mRNA expression of GDNF, which suggests that simulated weightlessness can cause damage changes in rat dorsal root ganglion.%目的:探讨模拟失重对背根神经节(dorsal root ganglia,DRG)及胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)的影响。方法健康雄性SD大鼠80只,随机分为尾部悬吊(HU)组(n=40)和正常对照(NC)组(n=40),4周后处死各组大鼠,取腰5背根神经节,甲苯氨兰染色观察背根神经节内尼氏小体变化,免疫组化观察GDNF的变化, Western-blot方法检测GDNF的蛋白表达,实时PCR检测GDNF mRNA表达情况。结果与NC组相比,HU组尼氏体染色浅,尼氏体变小,弥散分布。免疫组化结果显示,与NC组比较,HU组GDNF量及积分光密度(integral optical density,IOD)值减少(P<0.05)。Western-blot结果

  8. Morphologic alterations after transluminal angioplasty

    International Nuclear Information System (INIS)

    Despite the widespread clinical use of percutaneous transluminal angioplasty, the mechanism by which enlargement of the arterial lumen is achieved by this technique has been poorly understood. In the original description of transluminal angioplasty in 1964, the effectiveness of the procedure was attributed to compression of the atheromatous plaque against a relatively unyielding artery wall. This mechanism was subsequently endorsed in relation to angioplasty using the balloon catheter. The concept of plaque compression or displacement or of herniation of the puttylike athermatous intima into the artery wall was generally accepted by the early pioneers in transluminal angioplasty. This mechanism did not, however, correspond to clinical and morphologic observations that plaques were generally rigid and calcific rather than plastic and could not readily be compressed or deformed. Angiographic observations before and after dilatation have not always been helpful in defining the mechanism since angiography reveals only the lumen contour and does not provide sufficient information concerning the thickness of the arterial wall or the size, configuration, or precise boundaries of plaques. Although direct observation of lesions and associated artery walls immediately after balloon dilatation could provide the necessary information, such data are difficult to obtain since arteries and plaques are rarely directly inspected after dilatation in the living patient. Knowledge of the morphologic consequences of balloon dilatation in human arteries has therefore been obtained mainly from experimental studies of postmortem arteries and corresponding angiographic images and from specimens obtained from amputated limbs or after death

  9. 纽绵蚧跳小蜂在蚧虫体内发育的形态观察(膜翅目:跳小蜂科)%Observation of the Morphology during Development of Encyrtus sasakii (Hymenoptera: Encyrtidae) in the Body of its Host Scale Insect Eulecanium kuwanai

    Institute of Scientific and Technical Information of China (English)

    谢映平; 傅晓虹; 薛皎亮; 张小民; 张艳峰

    2007-01-01

    过解剖皱大球坚蚧Eulecanium kuwanai Kanda雌成虫,对寄生在其内的纽绵蚧跳小蜂Encyrtus sasakii Ishii的各个虫期的形态特征进行了观察比较,并做了显微拍照.结果显示,纽绵蚧跳小蜂一年发生一代,以蛹在寄主体内越冬.除虫体由龄期引起的个体差异外,纽绵蚧跳小蜂的一、二龄幼虫腹部末端都具有长形通气柄,到第三、四龄期其通气柄变为尾囊状构造.成虫期的雌性小蜂中胸小盾片为黄色,前翅淡烟色并有一个暗斑,上密生黑色粗毛;雄性的为黑色,前翅色淡,无暗斑.%Observed and compared the morphological characters of various instars of Encyrtus sasakii Ishii parasitized in Eulecanium kuwanai Kanda. Microphotographs were taken of the bodies. Study shows that: Encyrtus sasakii Ishii reproduces annually and overwinters as pupa in their host. Besides the individual differences resulting from development, the 1st and 2nd instar larvae have long breath pedicles in the end of abdomen, and with the larva molting during development, the exuvia accumulate at the end of the body, form a hollow sac called caudal sac that cover the breath pedicle during 3rd and 4th instar larvae. The scutulis of females are yellow, and foreside of wings is light fumed with a dark blotch covered by dense black thick hairs. While the males are black brown, the wing is light in color without a dark blotch.

  10. Sacralising Bodies

    DEFF Research Database (Denmark)

    Kaur, Ravinder

    2010-01-01

    In post-revolution Iran, the sacred notion of martyrdom has been transformed into a routine act of government – a moral sign of order and state sovereignty. Moving beyond the debates of the secularisation of the sacred and the making sacred of the secular, this article argues that the moment...... of sacralisation is realised through co-production within a social setting when the object of sacralisation is recognised as such by others. In contemporary Iran, however, the moment of sacralising bodies by the state is also the moment of its own subversion as the political-theological field of martyrdom......-sacrifice became central to the mass mobilisation against the monarchy. Once the revolutionary government came into existence, this sacred tradition was regulated to create ‘martyrs’ as a fixed category, in order to consolidate the legacy of the revolution. In this political theatre, the dead body is a site...

  11. Development and pre-clinical evaluation of a real time monitoring and feedback system for deep inspiration breath hold for stereotactic body radiotherapy

    International Nuclear Information System (INIS)

    Full text: Background. Respiration can cause tumour movements in the thoracic region up to 3 cm. Currently, there are several approaches under development and/or evaluation to minimize the internal margin which is generally applied to account for motion effects. One approach is the deep inspiration breath hold (DIBH) technique to immobilize the target and to deliver a beam during breath hold. Such an approach has the additional advantage of an increased lung volume with decreased lung density. However, the application of respiration-controlled delivery in stereotactic body radiotherapy (SBRT) still remains a challenge and the treatment for the optimal therapeutic benefit (TCP/NTCP) is still under evaluation. technique Material and methods The BrainLAB ExacTrac system was used to monitor deep inspiration for patients immobilized in a stereotactic bodyframe. As in the standard procedure for patient positioning using ExacTrac, several markers are placed on the patient's skin, preferably close to the target position and on the sternum. During training sessions the dominant direction of marker movement was determined. Using an in-house developed interface, online information about respiration movements of the thorax (determined form ExacTrac marker) was displayed. Additionally, a patient feedback system was developed to visualize the respiration cycle to the patient and thus to utilize his/her ability for cooperation. The feedback system was tested with 35 patients undergoing SBRT. In a multislice CT study, the underlying hypothesis that targets can be immobilized with high accuracy with a DIBH maneuver and that ExacTrac marker can be used as surrogate was verified for 16 patients. The DIBH reproducibility and stability were determined from multislice CT studies with multiple (4-5) DIBH maneuvers and from various training sessions with patients. In a subsequent treatment planning study, 13 patients with lung lesion undergoing SBRT treatment underwent additional multi

  12. 1.5 T Whole Body Diffusion Weighted-Imaging and Its Clinical Application Value%1.5 T磁共振全身弥撒加权成像的临床应用价值

    Institute of Scientific and Technical Information of China (English)

    张燕; 陈忠明; 蔡望洲

    2015-01-01

    目的:探讨1.5 T磁共振全身弥散加权成像的临床应用价值。方法:收集本院行1.5 T磁共振全身弥散加权成像的自愿者4例、肿瘤患者9例、体检者4例,采用最大密度投影重建法及反窗视图,获得全身薄层弥散加权及其三维图像,并对发现疑有阳性病变的再进行局部常规MRI或CT扫描,对其影像图像进行评价及统计学分析。结果:16例获得清晰的三维图像,图像可评价性为91.1%,其中3例自愿者及2例体检者检查结果为阴性,1例自愿者检出睾丸鞘膜积液,2例体检者均检出囊性病变,8例肿瘤患者均检出转移灶,阳性率约68.8%,对恶性肿瘤的检出率为88.9%;对肿瘤的诊断效果与常规MRI或CT一致性良好,差异无统计学意义(P>0.05)。结论:磁共振全身弥散加权成像具备了探测疾病的敏感性,能基本满足临床体检筛查及诊断,可用于常规体检,且对恶性肿瘤的筛查诊断具有较高的临床应用价值。%Objective:To explore 1.5 T Whole Body Diffusion Weighted-Imaging and its clinical application value.Method:4 volunteers, 9 cancer patients and 4 health examination in our hospital were collected for 1.5 T whole body diffusion weighted imaging of volunteers, with maximum intensity projection method and anti window view, got a total body thin diffusion weighted and 3D images, and found the suspicious positive lesions to bureau of the Ministry of the conventional MRI or CT scanning, analysis and evaluation and statistics on the image.Result:16 cases got clear three-dimensional images, image evaluation was 91.1%, of which 3 volunteers and 2 patients tested negative, 1 cases were detected in testicular hydrocele, 2 cases were cystic lesions, 8 cases of tumor patients with metastasis detection, the positive rate was about 68.8%, the detection of malignant the tumor was 88.9%, the diagnostic effect on tumor and normal MRI or CT consistency was good, no

  13. Evolution of body size in Galapagos marine iguanas

    OpenAIRE

    Wikelski, Martin

    2005-01-01

    Body size is one of the most important traits of organisms and allows predictions of an individual's morphology, physiology, behaviour and life history. However, explaining the evolution of complex traits such as body size is difficult because a plethora of other traits influence body size. Here I review what we know about the evolution of body size in a group of island reptiles and try to generalize about the mechanisms that shape body size. Galapagos marine iguanas occupy all 13 larger isla...

  14. Morphological neural networks

    Energy Technology Data Exchange (ETDEWEB)

    Ritter, G.X.; Sussner, P. [Univ. of Florida, Gainesville, FL (United States)

    1996-12-31

    The theory of artificial neural networks has been successfully applied to a wide variety of pattern recognition problems. In this theory, the first step in computing the next state of a neuron or in performing the next layer neural network computation involves the linear operation of multiplying neural values by their synaptic strengths and adding the results. Thresholding usually follows the linear operation in order to provide for nonlinearity of the network. In this paper we introduce a novel class of neural networks, called morphological</