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Sample records for bnct research program

  1. INEL BNCT Research Program annual report 1994

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  2. INEL BNCT Research Program annual report, 1992

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    Venhuizen, J.R. [ed.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.

  3. INEL BNCT research program: Annual report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented.

  4. INEEL BNCT Research Program Annual Report, CY-2000

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    Venhuizen, James Robert

    2001-03-01

    This report is a summary of the activities conducted in conjunction with the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 2000. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, neutron source design and demonstration, and support the Department of Energy’s (DOE) National BNCT Program goals are the goals of this Program. Contributions from the individual contributors about their projects are included, specifically described are the following, chemistry: analysis of biological samples and an infrared blood-boron analyzer, and physics: progress in the patient treatment planning software, measurement of neutron spectra for the Argentina RA-6 reactor, and recalculation of the Finnish research reactor FiR 1 neutron spectra, BNCT accelerator technology, and modification to the research reactor at Washington State University for an epithermal-neutron beam.

  5. INEL BNCT Program

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    Ackermann, A.L. (ed.)

    1991-08-01

    This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  6. INEL BNCT Research Program Annual Report 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1994-08-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from all the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, boron drug analysis), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented. Results of 21 spontaneous-tumor-bearing dogs that have been treated with boron neutron capture therapy at the Brookhaven National Laboratory are updated. Boron-containing drug purity verification is discussed in some detail. Advances in magnetic resonance imaging of boron in vivo are discussed. Several boron-carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Measurement of the epithermal-neutron flux of the Petten (The Netherlands) High Flux Reactor beam (HFB11B), and comparison to predictions are shown.

  7. INEL BNCT research program, July--August 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-10-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  8. INEL BNCT Research Program, May/June 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-09-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (IBPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  9. INEL BNCT Research Program, March/April 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-09-01

    This report presents summaries for two months of current research for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murino screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronopheoylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  10. INEL BNCT Research Program, September--October 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-12-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotain. carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophonylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  11. INEL BNCT Research Program, January/February 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-04-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  12. INEEL BNCT research program. Annual report, January 1, 1996--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1997-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of {sup 10}B enriched decaborane.

  13. INEL BNCT Research Program, March/April 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-06-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium and boronophenylalanine are described. Treatment protocol development via the large animal (canine) modal studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  14. INEL BNCT Program: Volume 5, No. 9

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.)

    1991-01-01

    This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  15. INEL BNCT Program: Volume 5, No. 9. Bulletin, September 1991

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. [ed.

    1991-12-31

    This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  16. Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research

    Energy Technology Data Exchange (ETDEWEB)

    Subhash Chandra

    2008-05-30

    The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.

  17. INEL BNCT Program: Bulletin, Volume 5, No. 7

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.)

    1991-07-01

    This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for June, 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and animal data charts. Specific highlights include: final-dosage-form BSH samples were analyzed for purity, with the sample from Centronic Ltd the most free from contamination and oxidation products; MRI spectroscopy will be upgraded to provide a potential for boron resolution of 0.75 cm/pixel; neutron and gamma measurements were made for the HFR epithermal neutron beam; the current status of six spontaneous brain-tumor dogs; production of MoAbs against the pituitary CRF receptor; growth of BL6 in low Phe/Tyr medium; an altered synthetic pathway for carboranyl alanine; and encapsulation of {ital i}-B{sub 20}H{sub 18}{sup 2-} into liposomes for baseline murine studies. 2 figs., 4 tabs. (MHB)

  18. A feasibility study of the Tehran research reactor as a neutron source for BNCT.

    Science.gov (United States)

    Kasesaz, Yaser; Khalafi, Hossein; Rahmani, Faezeh; Ezati, Arsalan; Keyvani, Mehdi; Hossnirokh, Ashkan; Shamami, Mehrdad Azizi; Monshizadeh, Mahdi

    2014-08-01

    Investigation on the use of the Tehran Research Reactor (TRR) as a neutron source for Boron Neutron Capture Therapy (BNCT) has been performed by calculating and measuring energy spectrum and the spatial distribution of neutrons in all external irradiation facilities, including six beam tubes, thermal column, and the medical room. Activation methods with multiple foils and a copper wire have been used for the mentioned measurements. The results show that (1) the small diameter and long length beam tubes cannot provide sufficient neutron flux for BNCT; (2) in order to use the medical room, the TRR core should be placed in the open pool position, in this situation the distance between the core and patient position is about 400 cm, so neutron flux cannot be sufficient for BNCT; and (3) the best facility which can be adapted for BNCT application is the thermal column, if all graphite blocks can be removed. The epithermal and fast neutron flux at the beginning of this empty column are 4.12×10(9) and 1.21×10(9) n/cm(2)/s, respectively, which can provide an appropriate neutron beam for BNCT by designing and constructing a proper Beam Shaping Assembly (BSA) structure.

  19. Epithermal neutron beam for BNCT research at the Washington State University TRIGA research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nigg, D.W.; Venhuizen, J.R.; Wheeler, F.J.; Wemple, C.A. [Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID (United States); Tripard, G.E.; Gavin, P.R. [Washington State University, Pullman, WA (United States)

    2000-10-01

    A new epithermal-neutron beam facility for BNCT (Boron Neutron Capture Therapy) research and boronated agent screening in animal models is in the final stages of construction at Washington State University (WSU). A key distinguishing feature of the design is the incorporation of a new, high-efficiency, neutron moderating and filtering material, Fluental, developed by the Technical Research Centre of Finland. An additional key feature is the provision for adjustable filter-moderator thickness to systematically explore the radiobiological consequences of increasing the fast-neutron contamination above the nominal value associated with the baseline system. (author)

  20. BNCT-RTPE: BNCT radiation treatment planning environment

    Energy Technology Data Exchange (ETDEWEB)

    Wessol, D.E.; Wheeler, F.J. [Idaho National Engineering Lab., Idaho Fall, ID (United States); Babcock, R.S. [and others

    1995-11-01

    Several improvements have been developed for the BNCT radiation treatment planning environment (BNCT-Rtpe) during 1994. These improvements have been incorporated into Version 1.0 of BNCT-Rtpe which is currently installed at the INEL, BNL, Japanese Research Center (JRC), and Finland`s Technical Research Center. Platforms supported by this software include Hewlett-Packard (HP), SUN, International Business Machines (IBM), and Silicon Graphics Incorporated (SGI). A draft version of the BNCT-Rtpe user manual is available. Version 1.1 of BNCT-Rtpe is scheduled for release in March 1995. It is anticipated that Version 2.x of BNCT-Rtpe, which includes the nonproprietary NURBS library and data structures, will be released in September 1995.

  1. Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

    Science.gov (United States)

    Sakurai, Yoshinori; Tanaka, Hiroki; Takata, Takushi; Fujimoto, Nozomi; Suzuki, Minoru; Masunaga, Shinichiro; Kinashi, Yuko; Kondo, Natsuko; Narabayashi, Masaru; Nakagawa, Yosuke; Watanabe, Tsubasa; Ono, Koji; Maruhashi, Akira

    2015-07-01

    At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system. The world's first accelerator-based neutron irradiation system for BNCT clinical irradiation was completed at this institute in early 2009, and the clinical trial using this system was started in 2012. A shift of BCNT from special particle therapy to a general one is now in progress. To promote and support this shift, improvements to the irradiation system, as well as its preparation, and improvements in the physical engineering and the medical physics processes, such as dosimetry systems and quality assurance programs, must be considered. The recent advances in BNCT at KURRI are reported here with a focus on physical engineering and medical physics topics.

  2. Design and construction of a thermal neutron beam for BNCT at Tehran Research Reactor.

    Science.gov (United States)

    Kasesaz, Yaser; Khalafi, Hossein; Rahmani, Faezeh; Ezzati, Arsalan; Keyvani, Mehdi; Hossnirokh, Ashkan; Shamami, Mehrdad Azizi; Amini, Sepideh

    2014-12-01

    An irradiation facility has been designed and constructed at Tehran Research Reactor (TRR) for the treatment of shallow tumors using Boron Neutron Capture Therapy (BNCT). TRR has a thermal column which is about 3m in length with a wide square cross section of 1.2×1.2m(2). This facility is filled with removable graphite blocks. The aim of this work is to perform the necessary modifications in the thermal column structure to meet thermal BNCT beam criteria recommended by International Atomic Energy Agency. The main modifications consist of rearranging graphite blocks and reducing the gamma dose rate at the beam exit. Activation foils and TLD700 dosimeter have been used to measure in-air characteristics of the neutron beam. According to the measurements, a thermal flux is 5.6×10(8) (ncm(-2)s(-1)), a cadmium ratio is 186 for gold foils and a gamma dose rate is 0.57Gy h(-1).

  3. Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor; Otimizacao do feixe de irradiacao na instalacao para estudos em BNCT junto ao reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Vinicius Alexandre de

    2014-07-01

    Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)

  4. Design of epithermal neutron beam for clinical BNCT treatment at Slovenian TRIGA research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Maucec, Marko [Jozef Stefan Institute, Reactor Physics Division, Lubljana (Slovenia). E-mail: marko.mauce@ijs.si

    1999-07-01

    The Monte Carlo feasibility study of development of epithermal neutron beam for BNCT clinical trials on Jozef Stefan Institute (JSI) TRIGA reactor is presented. The investigation of the possible use of fission converter for the purpose of enhancement of neutron beam, as well as the set-up of TRIGA reactor core is performed. The optimization of the irradiation facility components is carried out and the configuration with the most favorable cost/performance ratio is proposed. The simulation results prove that a BNCT irradiation facility with performances, comparable to existing beams throughout the world, could be installed in the thermalizing column of the TRIGA reactor, quite suitable for the clinical treatments of human patients. (author)

  5. Optimization of the irradiation beam in the bnct research facility at IEA-R1 reactor

    OpenAIRE

    Vinicius Alexandre de Castro

    2015-01-01

    A Terapia por Captura de Nêutrons pelo Boro (BNCT) é uma técnica radioterapêutica, que visa o tratamento de alguns tipos de câncer, em que sua energia útil é proveniente da reação nuclear promovida pela incidência de nêutrons térmicos no isótopo de 10B. No Brasil existe uma instalação, localizada junto ao canal de irradiação número 3 do Reator de Pesquisas IEA-R1 do IPEN, que foi projetada para o desenvolvimento de pesquisas em BNCT. Para uma aplicação adequada da técnica é necessário que o f...

  6. Optimization of Neutron Spectrum in Northwest Beam Tube of Tehran Research Reactor for BNCT, by MCNP Code

    Energy Technology Data Exchange (ETDEWEB)

    Zamani, M. [National Radiation Protection Department - NRPD, Atomic Energy Organization of Iran - AEOI, Tehran (Iran, Islamic Republic of); End of North Kargar st, Atomic Energy Organization of Iran, P.O. Box: 14155-1339, Tehran (Iran, Islamic Republic of); Kasesaz, Y.; Khalafi, H.; Shayesteh, M. [Radiation Application School, Nuclear Science and Technology Research Institute, AEOI, Tehran (Iran, Islamic Republic of)

    2015-07-01

    In order to gain the neutron spectrum with proper components specification for BNCT, it is necessary to design a Beam Shape Assembling (BSA), include of moderator, collimator, reflector, gamma filter and thermal neutrons filter, in front of the initial radiation beam from the source. According to the result of MCNP4C simulation, the Northwest beam tube has the most optimized neuron flux between three north beam tubes of Tehran Research Reactor (TRR). So, it has been chosen for this purpose. Simulation of the BSA has been done in four above mentioned phases. In each stage, ten best configurations of materials with different length and width were selected as the candidates for the next stage. The last BSA configuration includes of: 78 centimeters of air as an empty space, 40 centimeters of Iron plus 52 centimeters of heavy-water as moderator, 30 centimeters of water or 90 centimeters of Aluminum-Oxide as a reflector, 1 millimeters of lithium (Li) as thermal neutrons filter and finally 3 millimeters of Bismuth (Bi) as a filter of gamma radiation. The result of Calculations shows that if we use this BSA configuration for TRR Northwest beam tube, then the best neutron flux and spectrum will be achieved for BNCT. (authors)

  7. Boron neutron capture therapy (BNCT) for glioblastoma multiforme using the epithermal neutron beam at the Brookhaven Medical Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Capala, J. [Brookhaven National Lab., Upton, NY (United States); Diaz, A.Z.; Chadha, M. [Univ. Hospital, State Univ. of New York, NY (United States)] [and others

    1997-12-31

    The abstract describes evaluation of boron neutron capture therapy (BNCT) for two groups of glioblastoma multiforme patients. From September 1994 to February 1996 15 patients have been treated. In September 1997 another 34 patients were examined. Authors determined a safe starting dose for BNCT using epithermal neutrons and BPA-F. They have also evaluated adverse effects of BNCT at this starting dose. Therapeutic effectiveness of this starting dose has been evaluated. No significant side effects from BPA-F infusion or BNCT treatment were observed in normal brains.

  8. Spectral performance of a composite single-crystal filtered thermal neutron beam for BNCT research at the University of Missouri.

    Science.gov (United States)

    Brockman, J; Nigg, D W; Hawthorne, M F; McKibben, C

    2009-07-01

    Parameter studies, design calculations and initial neutronic performance measurements have been completed for a new thermal neutron beamline to be used for neutron capture therapy cell and small-animal radiobiology studies at the University of Missouri Research Reactor. The beamline features the use of single-crystal silicon and bismuth sections for neutron filtering and for reduction of incident gamma radiation. The calculated and measured thermal neutron fluxes produced at the irradiation location are 9.6 x 10(8) and 8.8 x 10(8)neutrons/cm(2)s, respectively. Calculated and measured cadmium ratios (Au foils) are 217 and 132. These results indicate a well-thermalized neutron spectrum with sufficient thermal neutron flux for a variety of small animal BNCT studies.

  9. Monte Carlo Calculation of Core Reactivity and Fluxes for the Development of the BNCT Neutron Source at the Kyiv Research Reactor

    Science.gov (United States)

    Gritzay, Olena; Kalchenko, Oleksandr; Klimova, Nataliya; Razbudey, Volodymyr; Sanzhur, Andriy; Binney, Stephen

    2005-05-01

    The presented results show our consecutive steps in developing a neutron source with parameters required by Boron Neutron Capture Therapy (BNCT) at the Kyiv Research Reactor (KRR). The main goal of this work was to analyze the influence of installation of different types of uranium converters close to the reactor core on neutron beam characteristics and on level of reactor safety. The general Monte Carlo radiation transport code MCNP, version 4B, has been used for these calculations.

  10. BNCT Technology Development on HANARO Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ki Jung; Park, Kyung Bae; Whang, Seung Ryul; Kim, Myong Seop

    2007-06-15

    So as to establish the biological effects of BNCT in the HANARO Reactor, biological damages in cells and animals with treatment of boron/neutron were investigated. And 124I-BPA animal PET image, analysis technology of the boron contents in the mouse tissues by ICP-AES was established. A Standard clinical protocol, a toxicity evaluation report and an efficacy investigation report of BNCT has been developed. Based on these data, the primary permission of clinical application was acquired through IRB of our hospital. Three cases of pre-clinical experiment for boron distribution and two cases of medium-sized animal simulation experiment using cat with verifying for 2 months after BNCT was performed and so the clinical demonstration with a patient was prepared. Also neutron flux, fast neutron flux and gamma ray dose of BNCT facility were calculated and these data will be utilized good informations for clinical trials and further BNCT research. For the new synthesis of a boron compound, o-carboranyl ethylamine, o-carboranylenepiperidine, o-carboranyl-THIQ and o-carboranyl-s-triazine derivatives were synthesized. Among them, boron uptake in the cancer cell of the triazine derivative was about 25 times than that of BPA and so these three synthesized methods of new boron compounds were patented.

  11. American brain tumor patients treated with BNCT in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Laramore, G.E.; Griffin, B.R.; Spence, A.

    1995-11-01

    The purpose of this work is to establish and maintain a database for patients from the United States who have received BNCT in Japan for malignant gliomas of the brain. This database will serve as a resource for the DOE to aid in decisions relating to BNCT research in the United States, as well as assisting the design and implementation of clinical trials of BNCT for brain cancer patients in this country. The database will also serve as an information resource for patients with brain tumors and their families who are considering this form of therapy.

  12. Boron neutron capture therapy (BNCT) in Finland: technological and physical prospects after 20 years of experiences.

    Science.gov (United States)

    Savolainen, Sauli; Kortesniemi, Mika; Timonen, Marjut; Reijonen, Vappu; Kuusela, Linda; Uusi-Simola, Jouni; Salli, Eero; Koivunoro, Hanna; Seppälä, Tiina; Lönnroth, Nadja; Välimäki, Petteri; Hyvönen, Heini; Kotiluoto, Petri; Serén, Tom; Kuronen, Antti; Heikkinen, Sami; Kosunen, Antti; Auterinen, Iiro

    2013-05-01

    Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy method developed to treat patients with certain malignant tumours. To date, over 300 treatments have been carried out at the Finnish BNCT facility in various on-going and past clinical trials. In this technical review, we discuss our research work in the field of medical physics to form the groundwork for the Finnish BNCT patient treatments, as well as the possibilities to further develop and optimize the method in the future. Accordingly, the following aspects are described: neutron sources, beam dosimetry, treatment planning, boron imaging and determination, and finally the possibilities to detect the efficacy and effects of BNCT on patients.

  13. In-vivo measurements with TLD detectors for BNCT of glioblastoma patients at the high-flux research reactor petten/NL

    Energy Technology Data Exchange (ETDEWEB)

    Finke, E.; Hideghety, K.; Rassow, J.; Sauerwein, W. [Universitaetsklinikum, Essen (Germany); Kessler, C. [Comision Nacional de Energia Atomica, Laboratorio Secundario de Calibracion Dosimetricqa, Buenos Aires (Argentina); Morrissey, J.; Moss, R. [JRC Joint Research Center, Petten (Netherlands); Stecher-Rasmussen, F.; Verhagen, H.W. [NRG (an ECN Kema Company), Petten (Netherlands)

    2000-10-01

    Base of this investigation is an experimental test, which TLD detector material is best suited for indication of a representative dose component for in-vivo measurements at BNCT patients treated with epithermal neutrons of a constant energy spectrum. In-vivo measurements with Thermoluminescence detectors CaF{sub 2}:Tm (TLD 300) were carried out during irradiation of four BNCT-patients. (author)

  14. Characterisation of the TAPIRO BNCT epithermal facility.

    Science.gov (United States)

    Burn, K W; Colli, V; Curzio, G; d'Errico, F; Gambarini, G; Rosi, G; Scolari, L

    2004-01-01

    A collimated epithermal beam for boron neutron capture therapy (BNCT) research has been designed and built at the TAPIRO fast research reactor. A complete experimental characterisation of the radiation field in the irradiation chamber has been performed, to verify agreement with IAEA requirements. Slow neutron fluxes have been measured by means of an activation technique and with thermoluminescent detectors (TLDs). The fast neutron dose has been determined with gel dosemeters, while the fast neutron spectrum has been acquired by means of a neutron spectrometer based on superheated drop detectors. The gamma-dose has been measured with gel dosemeters and TLDs. For an independent verification of the experimental results, fluxes, doses and neutron spectra have been calculated with Monte Carlo simulations using the codes MCNP4B and MCNPX_2.1.5 with the direct statistical approach (DSA). The results obtained confirm that the epithermal beams achievable at TAPIRO are of suitable quality for BNCT purposes.

  15. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

    OpenAIRE

    Akan, Zafer; Demiroglu, Hasan; Avcibasi, Ugur; Oto, Gokhan; Ozdemir, Hulya; Deniz, Sabahattin; Basak, Ali Sadi

    2014-01-01

    Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching fo...

  16. Building of scientific information system for sustainable development of BNCT in Bulgaria.

    Science.gov (United States)

    Mitev, M; Ilieva, K; Apostolov, T

    2009-07-01

    Building a boron neutron capture therapy (BNCT) facility is foreseen within the reconstruction of the Research Reactor IRT (IRT) of the Institute for Nuclear Research and Nuclear Energy of the Bulgaria Academy of Sciences (INRNE). The development of BNCT at IRT plays a very significant role in the plan for sustainable application of the reactor. A centralized scientific information system on BNCT is being built at the INRNE with the purpose to collect and sort new information as knowledge accumulated during more than thirty years history of BNCT. This BNCT information system will help the creation and consolidation of a well informed and interconnected interdisciplinary team of physicists, chemists, biologists, and radio-oncologists for establishing BNCT cancer treatment in Bulgaria. It will strengthen more intensive development of the national network as well as its enlargement to the Balkan region countries. Furthermore, to acquaint the public at large with the opportunity for BNCT cancer treatment will be addressed. Human, social, and economics results due to BNCT for many patients from Balkan region are expected.

  17. Effectiveness of BNCT for recurrent head and neck malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Itsuro E-mail: katoitsu@dent.osaka-u.ac.jp; Ono, Koji; Sakurai, Yoshinori; Ohmae, Masatoshi; Maruhashi, Akira; Imahori, Yoshio; Kirihata, Mitsunori; Nakazawa, Mitsuhiro; Yura, Yoshiaki

    2004-11-01

    Recurrent head and neck malignancies (HNM) are often radio-/chemo-resistant and show extensive growth, necessitating a wide resection including surrounding tissues. To avoid severe impairment of oro-facial structures and functions, it is necessary to explore new treatments for HNM. Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional radiotherapies in principle. We report here, first in the world, six patients with a recurrent HNM who have been treated with BNCT. The BNCT in combination with boronophenylalanine (BPA) and borocaptate sodium (BSH) was performed using the epithermal neutrons with Kyoto University Research Reactor (KUR). The results of BNCT were as follows: (1) {sup 10}B concentration of tumor/normal tissue ratios (T/N ratio) of PET studies were SCC:1.8-4.4, sarcoma:3.1-4.0, parotid tumor:3.5. (2) Relative volume (%) of each tumor to the prior were 6-46%. (3) Remarkable reduction (46-100%) of huge tumor such as 40-675 cm{sup 3} (average: 315 cm{sup 3}), improvement of QOL and very mild side effects were recognized in all cases. These results indicate that BNCT represents a new and promising treatment approach even for a huge or far advanced HNM.

  18. Correlation of clinical outcome to the estimated radiation dose from Boron Neutron Capture Therapy (BNCT)

    Energy Technology Data Exchange (ETDEWEB)

    Chadha, M. [Beth Israel Medical Center, NY (United States). Dept. of Radiation Oncology; Coderre, J.A.; Chanana, A.D. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-12-31

    A phase I/II trial delivering a single fraction of BNCT using p-Boronophenylalanine-Fructose and epithermal neutrons at the the Brookhaven Medical Research Reactor was initiated in September 1994. The primary endpiont of the study was to evaluate the feasibility and safety of a given BNCT dose. The clinical outcome of the disease was a secondary endpoint of the study. The objective of this paper is to evaluate the correlation of the clinical outcome of patients to the estimated radiation dose from BNCT.

  19. Characterisation of the TAPIRO BNCT thermal facility.

    Science.gov (United States)

    Rosi, G; Gambarini, G; Colli, V; Gay, S; Scolari, L; Fiorani, O; Perrone, A; Nava, E; Fasolo, F; Visca, L; Zanini, A

    2004-01-01

    Dosimetry and spectrometry measurements have been carried out in the thermal column of the research fast reactor RSV-TAPIRO (ENEA-Casaccia, Rome) in order to investigate its suitability for irradiation of cells or mice, with a view to research in the interests of boron neutron capture therapy (BNCT). The thermal column consists of a graphite moderator (40 cm thick) containing a lead shield (13 cm thick) in order to shield reactor background. The irradiation volume, inside this structure, has cubic shape (18 x 18 x 18 cm3). Besides measurements of fluence and dose rates in air or in phantom performed with thermoluminescence dosemeters (TLDs) and using the activation technique, dose and fluence profiles have been generated using a method based on gel dosemeters analysed with optical imaging. To check the consistency of the results, spectrometry measurements in the same irradiation volume have been performed by means of bubble detectors.

  20. Treatment Planning Systems for BNCT Requirements and Peculiarities

    CERN Document Server

    Daquino, G G

    2003-01-01

    The main requirements and peculiarities expected from the BNCT-oriented treatment planning system (TPS) are summarized in this paper. The TPS is a software, which can be integrated or composed by several auxiliary programs. It plays important roles inside the whole treatment planning of the patient's organ in BNCT. However, the main goal is the simulation of the irradiation, in order to obtain the optimal configuration, in terms of neutron spectrum, patient positioning and dose distribution in the tumour and healthy tissues. The presence of neutrons increases the level of complexity, because much more nuclear reactions need to be monitored and properly calculated during the simulation of the patient's treatment. To this purposes several 3D geometry reconstruction techniques, generally based on the CT scanning data, are implemented and Monte Carlo codes are normally used. The TPSs are expected to show also the results (basically doses and fluences) in a proper format, such as isocurves (or isosurfaces) along t...

  1. Preliminary modeling of BNCT beam tube on IRT in Sofia.

    Science.gov (United States)

    Belousov, S; Ilieva, K

    2009-07-01

    The technical design of the research reactor IRT in Sofia is in progress. It includes an arrangement for a BNCT facility for tumor treatment. Modeling of geometry and material composition of filter/collimator for the BNCT beam tube on IRT has been carried out following the beam tube configuration of the Massachusetts Institute of Technology Reactor [Harling et al., 2002. The fission converter-based epithermal neutron irradiation facility at the Massachusetts Institute of Technology Reactor. Nucl. Sci. Eng. 140, 223-240.] and taking into account an ability to include the tube into the IRT reactor geometry. The results of neutron and gamma transport calculations performed for the model have shown that the facility will be able to supply an epithermal neutron flux of about 5 x 10(9) n cm(-2)s(-1), with low contamination from fast neutrons and gamma rays that would be among the best facilities currently available. An optimiziation study has been performed for the beam collimator, following similar studies for the TAPIRO research reactor in Italy. [Nava et al., 2005. Monte Carlo optimization of a BNCT facility for treating brain gliomas at the TAPIRO reactor. Radiat. Prot. Dosim. 116 (1-4), 475-481.].

  2. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  3. The Seinhorst Research Program

    NARCIS (Netherlands)

    Schomaker, C.H.; Been, T.H.

    1998-01-01

    We propose the 'Seinhorst Research Program', derived from Seinhorst's empirical philosophy. All theories of the 'Seinhorst Research Program' are developed by searching for recurring regularities (patterns) in a collection of observations, named 'the empirical base'. To prevent 'ghost theories from s

  4. Measurement and simulation of the TRR BNCT beam parameters

    Science.gov (United States)

    Bavarnegin, Elham; Sadremomtaz, Alireza; Khalafi, Hossein; Kasesaz, Yaser; Golshanian, Mohadeseh; Ghods, Hossein; Ezzati, Arsalan; Keyvani, Mehdi; Haddadi, Mohammad

    2016-09-01

    Recently, the configuration of the Tehran Research Reactor (TRR) thermal column has been modified and a proper thermal neutron beam for preclinical Boron Neutron Capture Therapy (BNCT) has been obtained. In this study, simulations and experimental measurements have been carried out to identify the BNCT beam parameters including the beam uniformity, the distribution of the thermal neutron dose, boron dose, gamma dose in a phantom and also the Therapeutic Gain (TG). To do this, the entire TRR structure including the reactor core, pool, the thermal column and beam tubes have been modeled using MCNPX Monte Carlo code. To measure in-phantom dose distribution a special head phantom has been constructed and foil activation techniques and TLD700 dosimeter have been used. The results show that there is enough uniformity in TRR thermal BNCT beam. TG parameter has the maximum value of 5.7 at the depth of 1 cm from the surface of the phantom, confirming that TRR thermal neutron beam has potential for being used in treatment of superficial brain tumors. For the purpose of a clinical trial, more modifications need to be done at the reactor, as, for example design, and construction of a treatment room at the beam exit which is our plan for future. To date, this beam is usable for biological studies and animal trials. There is a relatively good agreement between simulation and measurement especially within a diameter of 10 cm which is the dimension of usual BNCT beam ports. This relatively good agreement enables a more precise prediction of the irradiation conditions needed for future experiments.

  5. Measurement and simulation of the TRR BNCT beam parameters

    Energy Technology Data Exchange (ETDEWEB)

    Bavarnegin, Elham [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Sadremomtaz, Alireza [Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Khalafi, Hossein [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Kasesaz, Yaser, E-mail: ykasesaz@aeoi.org.ir [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Golshanian, Mohadeseh; Ghods, Hossein; Ezzati, Arsalan; Keyvani, Mehdi; Haddadi, Mohammad [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of)

    2016-09-11

    Recently, the configuration of the Tehran Research Reactor (TRR) thermal column has been modified and a proper thermal neutron beam for preclinical Boron Neutron Capture Therapy (BNCT) has been obtained. In this study, simulations and experimental measurements have been carried out to identify the BNCT beam parameters including the beam uniformity, the distribution of the thermal neutron dose, boron dose, gamma dose in a phantom and also the Therapeutic Gain (TG). To do this, the entire TRR structure including the reactor core, pool, the thermal column and beam tubes have been modeled using MCNPX Monte Carlo code. To measure in-phantom dose distribution a special head phantom has been constructed and foil activation techniques and TLD700 dosimeter have been used. The results show that there is enough uniformity in TRR thermal BNCT beam. TG parameter has the maximum value of 5.7 at the depth of 1 cm from the surface of the phantom, confirming that TRR thermal neutron beam has potential for being used in treatment of superficial brain tumors. For the purpose of a clinical trial, more modifications need to be done at the reactor, as, for example design, and construction of a treatment room at the beam exit which is our plan for future. To date, this beam is usable for biological studies and animal trials. There is a relatively good agreement between simulation and measurement especially within a diameter of 10 cm which is the dimension of usual BNCT beam ports. This relatively good agreement enables a more precise prediction of the irradiation conditions needed for future experiments.

  6. Bnct

    Science.gov (United States)

    Rossi, F.; Ono, K.; Suzuki, M.; Tanaka, H.; Morigi, M. P.

    The purpose of this work is to analyze dose distribution inside tissues. To do this, we performed some MCNP simulations using the neutron flux obtained from the Kyoto University Reactor. We have tried to analyze the behavior of neutrons in different types of tissues in relation to their depth. We have found that the value of dose from neutron interaction with 10B depends not only on 10B concentration inside the tissues (a higher concentration produces a higher dose), but also on the tissue density. In fact, tissues with a density considerably different from that of water receive a lower dose. Another dose contribution is given by the presence of 14N inside tissues: this dose contribution is lower compared with the previous one; it is influenced both by the tissue density and the percentage of nitrogen inside the tissue. Finally, the delivered dose decreases very quickly after a depth of about 4 cm, which implies that boron neutron capture therapy is not an effective therapy for the deepest tumors. However, there are some factors that can be taken into account to reach the deepest zone.

  7. Be target development for the accelerator-based SPES-BNCT facility at INFN Legnaro.

    Science.gov (United States)

    Esposito, J; Colautti, P; Fabritsiev, S; Gervash, A; Giniyatulin, R; Lomasov, V N; Makhankov, A; Mazul, I; Pisent, A; Pokrovsky, A; Rumyantsev, M; Tanchuk, V; Tecchio, L

    2009-07-01

    An accelerator-driven thermal neutron source for BNCT, planned to be installed at the INFN Laboratori Nazionali di Legnaro (LNL), is in progress in the framework of the SPES (selective production of exotic species) research program. The most critical element of such a facility is the construction of a reliable neutron converter based on the (9)Be(p,xn) nuclear reaction, working at a high power level (150 kW) and 5 MeV beam energy, due to the SPES driver constraints. Two original, beryllium-based, target concepts have been designed for such a purpose. The present status of the neutron converter, as well as the test results performed so far on prototypes constructed, is reported here.

  8. A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Cruickshank, G.S. [University of Birmingham and University Hospital Birmingham, Birmingham (United Kingdom)], E-mail: garth.cruickshank@uhb.nhs.uk; Ngoga, D.; Detta, A.; Green, S.; James, N.D.; Wojnecki, C.; Doran, J.; Hardie, J.; Chester, M.; Graham, N.; Ghani, Z. [University of Birmingham and University Hospital Birmingham, Birmingham (United Kingdom); Halbert, G.; Elliot, M.; Ford, S. [CR-UK Formulation Unit, University of Strathclyde, Glasgow (United Kingdom); Braithwaite, R.; Sheehan, T.M.T. [Regional Laboratory for Toxicology, Sandwell and West Birmingham Hospitals Trust, Birmingham (United Kingdom); Vickerman, J.; Lockyer, N. [Surface Analysis Research Centre, University of Manchester, Manchester (United Kingdom); Steinfeldt, H.; Croswell, G. [CR-UK Drug Development Office, London (United Kingdom)] (and others)

    2009-07-15

    This paper describes results to-date from a human pharmacokinetic study which began recruitment in December 2007. Results are presented for a single patient recruited in December 2007. A second patient was recruited in July 2008 but detailed data are not available at the time of writing. The trial is an open-label, non-comparative, non-therapeutic study of BPA-mannitol in patients with high-grade glioma, who will be undergoing stereotactic brain biopsy as part of the diagnostic process before definitive treatment. The study investigates the route of infusion (intra-venous (IV) or intra-carotid artery) and in each case will assess the effect of administration of mannitol as a blood-brain barrier disrupter. All cohorts will receive a 2 h infusion of BPA-mannitol, and for some cohorts an additional mannitol bolus will be administered at the beginning of this infusion. Measurements are made by inductively coupled plasma mass spectrometry (ICP-MS) of {sup 10}B concentration in samples of blood, urine, extra-cellular fluid in normal brain (via a dialysis probe), brain tissue around tumour and tumour tissue. Additional analysis of the tumour tissue is performed using secondary ion mass spectrometry (SIMS). The first patient was part of the cohort having intra-venous infusion without mannitol bolus. No serious clinical problems were experienced and the assay results can be compared with available patient data from other BNCT centres. In particular we note that the peak {sup 10}B concentration in blood was 28.1 mg/ml for a total BPA administration of 350 mg/kg which is very consistent with the previous experience with BPA-fructose reported by the Helsinki group.

  9. Cyclotron-based neutron source for BNCT

    Science.gov (United States)

    Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K.; Tanaka, H.; Sakurai, Y.; Maruhashi, A.

    2013-04-01

    Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation & treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8×109 neutrons/cm2/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with 10B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

  10. Cyclotron-based neutron source for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K. [Sumitomo Heavy Industries, Ltd (Japan); Tanaka, H.; Sakurai, Y.; Maruhashi, A. [Kyoto University Research Reactor Institute (Japan)

    2013-04-19

    Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation and treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8 Multiplication-Sign 109 neutrons/cm{sup 2}/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with {sup 10}B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

  11. Acquisition Research Program Homepage

    OpenAIRE

    2015-01-01

    Includes an image of the main page on this date and compressed file containing additional web pages. Established in 2003, Naval Postgraduate School’s (NPS) Acquisition Research Program provides leadership in innovation, creative problem solving and an ongoing dialogue, contributing to the evolution of Department of Defense acquisition strategies.

  12. Marine biosurfaces research program

    Science.gov (United States)

    The Office of Naval Research (ONR) of the U.S. Navy is starting a basic research program to address the initial events that control colonization of surfaces by organisms in marine environments. The program “arises from the Navy's need to understand and ultimately control biofouling and biocorrosion in marine environments,” according to a Navy announcement.The program, “Biological Processes Controlling Surface Modification in the Marine Environment,” will emphasize the application of in situ techniques and modern molecular biological, biochemical, and biophysical approaches; it will also encourage the development of interdisciplinary projects. Specific areas of interest include sensing and response to environmental surface (physiology/physical chemistry), factors controlling movement to and retention at surfaces (behavior/hydrodynamics), genetic regulation of attachment (molecular genetics), and mechanisms of attachment (biochemistry/surface chemistry).

  13. On-line neutron beam monitoring of the Finnish BNCT facility

    Science.gov (United States)

    Tanner, Vesa; Auterinen, Iiro; Helin, Jori; Kosunen, Antti; Savolainen, Sauli

    1999-02-01

    A Boron Neutron Capture Therapy (BNCT) facility has been built at the FiR 1 research reactor of VTT Chemical Technology in Espoo, Finland. The facility is currently undergoing dosimetry characterisation and neutron beam operation research for clinical trials. The healthy tissue tolerance study, which was carried out in the new facility during spring 1998, demonstrated the reliability and user-friendliness of the new on-line beam monitoring system designed and constructed for BNCT by VTT Chemical Technology. The epithermal neutron beam is monitored at a bismuth gamma shield after an aluminiumfluoride-aluminium moderator. The detectors are three pulse mode U 235-fission chambers for epithermal neutron fluence rate and one current mode ionisation chamber for gamma dose rate. By using different detector sensitivities the beam intensity can be measured over a wide range of reactor power levels (0.001-250 kW). The detector signals are monitored on-line with a virtual instrumentation (LabView) based PC-program, which records and displays the actual count rates and total counts of the detectors in the beam. Also reactor in-core power instrumentation and control rod positions can be monitored via another LabView application. The main purpose of the monitoring system is to provide a dosimetric link to the dose in a patient during the treatment, as the fission chamber count rates have been calibrated to the induced thermal neutron fluence rate and to the absorbed dose rate at reference conditions in a tissue substitute phantom.

  14. Sandia Combustion Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, S.C.; Palmer, R.E.; Montana, C.A. (eds.)

    1988-01-01

    During the late 1970s, in response to a national energy crisis, Sandia proposed to the US Department of Energy (DOE) a new, ambitious program in combustion research. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''user facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative-involving US inventories, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions several research projects which have been simulated by working groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship program, supported through the Office of Energy Research, has been instrumental in the success of some of these joint efforts. The remainder of this report presents results of calendar year 1988, separated thematically into eleven categories. Referred journal articles appearing in print during 1988 and selected other publications are included at the end of Section 11. Our traditional'' research activities--combustion chemistry, reacting flows, diagnostics, engine and coal combustion--have been supplemented by a new effort aimed at understanding combustion-related issues in the management of toxic and hazardous materials.

  15. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  16. Jointly Sponsored Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett A. Sondreal; John G. Hendrikson; Thomas A. Erickson

    2009-03-31

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC26-98FT40321 funded through the Office of Fossil Energy and administered at the National Energy Technology Laboratory (NETL) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy & Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying highly efficient, nonpolluting energy systems that meet the nation's requirements for clean fuels, chemicals, and electricity in the 21st century. The EERC in partnership with its nonfederal partners jointly performed 131 JSRP projects for which the total DOE cost share was $22,716,634 (38%) and the nonfederal share was $36,776,573 (62%). Summaries of these projects are presented in this report for six program areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, and (6) advanced materials. The work performed under this agreement addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration; near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources.

  17. Preliminary evaluations of the undesirable patient dose from a BNCT treatment at the ENEA-TAPIRO reactor.

    Science.gov (United States)

    Ferrari, P; Gualdrini, G; Nava, E; Burn, K W

    2007-01-01

    Boron neutron capture therapy (BNCT) is an experimental technique for the treatment of certain kinds of tumors. Research in BNCT is performed utilizing both thermal and epithermal neutron beams. Epithermal neutrons (0.4 eV-10 keV) penetrate more deeply into tissue and are thus used in non-superficial clinical applications such as the brain glioma. In the last few years, the fast reactor TAPIRO (ENEA-Casaccia Rome) has been employed as a neutron source for research into BNCT applications. Recently, an 'epithermal therapeutic column' has been designed and its construction has been completed. The Monte Carlo code MCNPX was employed to optimize the design of the column and to evaluate the dose profiles and the therapeutic parameters in the cranium of the anthropomorphic phantom ADAM. In the same context, some preliminary evaluations of the undesirable doses to the patient were performed with MCNPX. A hermaphrodite phantom derived from ADAM and EVA was employed to evaluate the energy deposition in some organs during a standard BNCT treatment. The total dose consists of the contributions from the primary neutron beam, the neutron interactions with boron and the neutron induced photons generated in the epithermal column structures and in the patient's tissues. The paper summarizes the computational procedure and provides a general dosimetric framework of the patient radiological protection aspects related to a BNCT treatment scenario at the TAPIRO reactor.

  18. A phantom experiment for the evaluation of whole body exposure during BNCT using cyclotron-based epithermal neutron source (C-BENS)

    Energy Technology Data Exchange (ETDEWEB)

    Tsukamoto, T., E-mail: t.tsukamoto@ft5.ecs.kyoto-u.ac.jp [Graduate School of Engineering, Kyoto University, Yoshida Honmachi, Sakyo-ku, Kyoto 606-8501 (Japan); Tanaka, H.; Yoshinaga, H. [Research Reactor Institute, Kyoto University, Asashiro-nishi 2-1010, Kumatori-cho, Osaka 590-0494 (Japan); Mitsumoto, T. [Sumitomo Heavy Industries, Ltd., Osaki 2-1-1, Shinagawa, Tokyo 141-6025 (Japan); Maruhashi, A.; Ono, K.; Sakurai, Y. [Research Reactor Institute, Kyoto University, Asashiro-nishi 2-1010, Kumatori-cho, Osaka 590-0494 (Japan)

    2011-12-15

    At Kyoto University Research Reactor Institute (KURRI), cyclotron-based epithermal neutron source was installed in December 2008, and the supplementary construction works have been performed. As of December 2010, the various irradiation characteristics important for BNCT were mostly evaluated. The whole body exposure during BNCT medical irradiation is one of the important characteristics. In this article, measurements of absorbed dose for thermal and fast neutrons and gamma-ray at ten positions corresponding to important organs are reported.

  19. NSTX Research Program

    Science.gov (United States)

    Peng, Martin; Ono, Masayuki; Kaye, Stan

    1998-11-01

    NSTX (National Spherical Torus Experiment) is currently being built at PPPL to enable experimentation to prove the fusion physics principles of the Spherical Torus (ST) plasmas at the MA level in current. First plasma is scheduled for or before April 1999. A national NSTX Research Team is organized to plan, implement, and begin in May 1999 the experiments. Research topics of interest will encompass noninductive startup of large plasma current; heating and current drive via rf and neutral beam injection; stability and beta limits; transport and fluctuations; and edge and scrape-off layer. The Research Program sets a goal for Phase I to study during the first 12 months plasmas with Ohmic heating alone and with moderate levels of HHFW heating and current drive (up to 4 MW). Coaxial Helicity Injection will be tested for initiating large plasma currents; modern Thomson scattering systems will be implemented. Phases II (first-stability regime) and III (advanced physics regime) would follow with full HHFW, addition of NBI (up to 11 MW in total power), and additional modern diagnostics (e.g., MSE, 2D-3D fluctuations).

  20. National NSTX Research Program

    Science.gov (United States)

    Peng, Y.-K. M. Peng

    1999-11-01

    The national NSTX (National Spherical Torus Experiment) Research Team plans to resume in Summer 1999 Spherical Torus Proof-of-Principle experimentation at the MA level. Research topics of interest will encompass noninductive startup of plasma current; heating and current drive via rf and neutral beam injection; stability and beta limits; transport and fluctuations; and edge and scrape-off layer. The Research Program sets a goal for studying during the 12-month period Ohmic heating plasmas and High Harmonic Fast Wave (HHFW) heating up to ~ 4 MW. Coaxial Helicity Injection will be tested for initiating substantial plasma currents. Modern diagnostics systems, including laser Thomson scattering will be brought online. Plans to investigate the "no-wall" regime with toroidal average beta up to 25% would follow using full HHFW and NBI power up to 11 MW for heating and current drive for up to ~ 5 s, aided by additional modern diagnostics (e.g., MSE, etc.). Database for this regime will be needed for designing Performance Extension tests at the 10-MA level of driven (Q 1) and possibly high-gain (Q 10) ST plasmas.

  1. An Accelerator Neutron Source for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Blue, Thomas, E

    2006-03-14

    The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were 1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, 2) that the patient treatment time be reasonable, 3) that the proton current required to treat patients in reasonable times be technologially achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally 4) that the treatment be safe for the patients.

  2. Component fragility research program

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, N.C.; Mochizuki, G.L.; Holman, G.S. (NCT Engineering, Inc., Lafayette, CA (USA); Lawrence Livermore National Lab., CA (USA))

    1989-11-01

    To demonstrate how high-level'' qualification test data can be used to estimate the ultimate seismic capacity of nuclear power plant equipment, we assessed in detail various electrical components tested by the Pacific Gas Electric Company for its Diablo Canyon plant. As part of our Phase I Component Fragility Research Program, we evaluated seismic fragility for five Diablo Canyon components: medium-voltage (4kV) switchgear; safeguard relay board; emergency light battery pack; potential transformer; and station battery and racks. This report discusses our Phase II fragility evaluation of a single Westinghouse Type W motor control center column, a fan cooler motor controller, and three local starters at the Diablo Canyon nuclear power plant. These components were seismically qualified by means of biaxial random motion tests on a shaker table, and the test response spectra formed the basis for the estimate of the seismic capacity of the components. The seismic capacity of each component is referenced to the zero period acceleration (ZPA) and, in our Phase II study only, to the average spectral acceleration (ASA) of the motion at its base. For the motor control center, the seismic capacity was compared to the capacity of a Westinghouse Five-Star MCC subjected to actual fragility tests by LLNL during the Phase I Component Fragility Research Program, and to generic capacities developed by the Brookhaven National Laboratory for motor control center. Except for the medium-voltage switchgear, all of the components considered in both our Phase I and Phase II evaluations were qualified in their standard commercial configurations or with only relatively minor modifications such as top bracing of cabinets. 8 refs., 67 figs., 7 tabs.

  3. Postoperative treatment of glioblastoma with BNCT at the petten irradiation facility (EORTC protocol 11,961).

    Science.gov (United States)

    Hideghéty, K; Sauerwein, W; Haselsberger, K; Grochulla, F; Fankhauser, H; Moss, R; Huiskamp, R; Gabel, D; de Vries, M

    1999-06-01

    The boron neutron capture therapy is based on the reaction occurring between the isotope 10B and thermal neutrons. A low energy neutron is captured by the nucleus and it disintegrates into two densely ionising particles, Li nucleus and He nucleus (alpha particle), with high biological effectiveness. On the basis of comprehensive preclinical investigations in the frame of the European Collaboration with Na2B12H11SH (BSH), as boron delivery agent, the first European phase I, clinical trial was designed at the only available epithermal beam in Europe, at the High Flux Reactor, Petten, in the Netherlands. The goal of this study is to establish the safe BNCT dose for cranial tumors under defined conditions. BNCT is applied as postoperative radiotherapy in 4 fractions, after removal of the tumor for a group of patients suffering from glioblastoma, who would have no benefit from conventional treatment, but have sufficient life expectancy to detect late radiation morbidity due to BNCT. The starting dose is set at 80% of the dose where neurological effects occurred in preclinical large animal experiments following a single fraction. The radiation dose will be escalated, by constant boron concentration in blood, in 4 steps for cohorts of ten patients, after an observation period of at least 6 months after the end of BNCT of the last patient of a cohort. The adverse events on healthy tissues due to BSH and due to the radiotherapy will be analysed in order to establish the maximal tolerated dose and dose limiting toxicity. Besides of the primary aim of this study the survival will be recorded. The first patient was treated in October 1997, and further four patients have been irradiated to-date. The protocol design proved to be well applicable, establishing the basis for scientific evaluation, for performance of safe patient treatment in a very complex situation and for opening the possibility to perform further clinical research work on BNCT.

  4. Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility (EORTC Protocol 11961)

    Energy Technology Data Exchange (ETDEWEB)

    Hideghety, K.; Sauerwein, W. [Strahlenklinik, Universitaetsklinikum Essen (Germany); Haselsberger, K. [Klinik fuer Neurochirurgie, Graz Univ. (Austria); Grochulla, F. [Klinik fuer Neurochirurgie, Zentralkrankenhaus Bremen (Germany); Frankhauser, H. [Service de Neurochirurgie, CHUV Lausanne (Switzerland); Moss, R. [European Commission Joint Research Centre Petten (Netherlands); Huiskamp, R. [Netherlands Energy Research Foundation, ECN Petten (Netherlands); Gabel, D. [Chemistry Dept., Univ. Bremen (Germany); Vries, M. de [EORTC, New Drug Development Office Amsterdam (Netherlands)

    1999-06-01

    The boron neutron capture therapy is based on the reaction occurring between the isotope {sup 10}B and thermal neutrons. A low energy neutron is captured by the nucleus and it disintegrates into two densely ionising particles, Li nucleus and He nucleus ({alpha} particle), with high biological effectiveness. On the basis of comprehensive preclinical investigations in the frame of the European Collaboration with Na{sub 2}B{sub 12}H{sub 11}SH (BSH), as boron delivery agent, the first European phase I, clinical trial was designed at the only available epithermal beam in Europe, at the High Flux Reactor, Petten, in the Netherland. The goal of this study is to establish the safe BNCT dose for cranial tumors under defined conditions. BNCT is applied as postoperative radiotherapy in 4 fractions, after removal of the tumor for a group of patients suffering from glioblastoma, who would have no benefit from conventional treatment, but have sufficient life expectancy to detect late radiation morbidity due to BNCT. The starting dose is set at 80% of the dose where neurological effects occured in preclinical large animal experiments following a single fraction. The radiation dose will be escalated, by constant boron concentration in blood, in 4 steps for cohorts of ten patients, after an observation period of at least 6 months after the end of BNCT of the last patient of a cohort. The adverse events on healthy tissues due to BSH and due to the radiotherapy will be analysed in order to establish the maximal tolerated dose and dose limiting toxicity. Besides of the primary aim of this study the survival will be recorded. The first patient was treated in October 1997, and further four patients have been irradiated todate. The protocol design proved to be well applicable, establishing the basis for scientific evaluation, for performance of safe patient treatment in a very complex situation and for opening the possibility to perform further clinical research work on BNCT. (orig.)

  5. Clinical Requirements and Accelerator Concepts for BNCT

    Science.gov (United States)

    Ludewigt, Bernhard A.

    1997-05-01

    Accelerator-driven epithermal neutron sources are an attractive alternative to nuclear reactors for Boron Neutron Capture Therapy (BNCT). In BNCT the goal of delivering a sufficient dose to the tumor without exceeding the dose limits of the surrounding normal tissues is achieved by administering a ^10B-containing compound which is selectively taken up in the tumor cells. Subsequent irradiation with epithermal neutrons leads to the release of short ranged (neutron-capture reaction. By carefully shaping the neutron spectrum the background dose, partially due to recoil protons and external gamma radiation, can be minimized and the depth dose distribution optimized. Excellent epithermal neutron beams for BNCT can be produced by bombarding a Li-target with a high current proton beam at energies ranging from the (p,n) reaction threshold to 2.5 MeV and subsequent moderation and filtering of the primary neutrons. In comparison the use of Be-targets and higher proton or deuteron energies, up to 20 MeV, leads to higher neutron yields but also to higher primary neutron energies requiring more moderation and resulting in less desirable neutron spectra. Accelerator options for possible neutron sources include dc-accelerators, RFQs, LINACs and cyclotrons. An electrostatic quadrupole (ESQ) accelerator has been chosen to provide a 2.5 MeV proton beam for the BNCT facility currently being designed at LBNL. An ESQ-accelerator is ideally suited to provide the high beam currents which are desired for producing high quality neutron beams for BNCT treatments. A novel power supply based on the air-coupled transformer concept is under development. It will enable the accelerator to deliver proton beam currents up to about 50 mA. A Li-target has been designed which can handle beam power in excess of 50 kW establishing the practicability of this approach. Monte Carlo simulation studies have shown that at a proton beam current of 20 mA high quality treatments for brain tumors can be delivered

  6. A toolkit for epithermal neutron beam characterisation in BNCT.

    Science.gov (United States)

    Auterinen, Iiro; Serén, Tom; Uusi-Simola, Jouni; Kosunen, Antti; Savolainen, Sauli

    2004-01-01

    Methods for dosimetry of epithermal neutron beams used in boron neutron capture therapy (BNCT) have been developed and utilised within the Finnish BNCT project as well as within a European project for a code of practise for the dosimetry of BNCT. One outcome has been a travelling toolkit for BNCT dosimetry. It consists of activation detectors and ionisation chambers. The free-beam neutron spectrum is measured with a set of activation foils of different isotopes irradiated both in a Cd-capsule and without it. Neutron flux (thermal and epithermal) distribution in phantoms is measured using activation of Mn and Au foils, and Cu wire. Ionisation chamber (IC) measurements are performed both in-free-beam and in-phantom for determination of the neutron and gamma dose components. This toolkit has also been used at other BNCT facilities in Europe, the USA, Argentina and Japan.

  7. Dosimetry and radiobiology at the new RA-3 reactor boron neutron capture therapy (BNCT) facility: application to the treatment of experimental oral cancer.

    Science.gov (United States)

    Pozzi, E; Nigg, D W; Miller, M; Thorp, S I; Heber, E M; Zarza, L; Estryk, G; Monti Hughes, A; Molinari, A J; Garabalino, M; Itoiz, M E; Aromando, R F; Quintana, J; Trivillin, V A; Schwint, A E

    2009-07-01

    The National Atomic Energy Commission of Argentina (CNEA) constructed a novel thermal neutron source for use in boron neutron capture therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The aim of the present study was to perform a dosimetric characterization of the facility and undertake radiobiological studies of BNCT in an experimental model of oral cancer in the hamster cheek pouch. The free-field thermal flux was 7.1 x 10(9) n cm(-2)s(-1) and the fast neutron flux was 2.5 x 10(6) n cm(-2)s(-1), indicating a very well-thermalized neutron field with negligible fast neutron dose. For radiobiological studies it was necessary to shield the body of the hamster from the neutron flux while exposing the everted cheek pouch bearing the tumors. To that end we developed a lithium (enriched to 95% in (6)Li) carbonate enclosure. Groups of tumor-bearing hamsters were submitted to BPA-BNCT, GB-10-BNCT, (GB-10+BPA)-BNCT or beam only treatments. Normal (non-cancerized) hamsters were treated similarly to evaluate normal tissue radiotoxicity. The total physical dose delivered to tumor with the BNCT treatments ranged from 6 to 8.5 Gy. Tumor control at 30 days ranged from 73% to 85%, with no normal tissue radiotoxicity. Significant but reversible mucositis in precancerous tissue surrounding tumors was associated to BPA-BNCT. The therapeutic success of different BNCT protocols in treating experimental oral cancer at this novel facility was unequivocally demonstrated.

  8. Space Technology Research Grants Program

    Data.gov (United States)

    National Aeronautics and Space Administration — The Space Technology Research Grants Program will accelerate the development of "push" technologies to support the future space science and exploration...

  9. Federal Wind Energy Research Program

    Science.gov (United States)

    1991-10-01

    The Office of Program Analysis (OPA) undertook an assessment of 55 research projects sponsored by the Federal Wind Energy Research Program. This report summarizes the results of that review. In accordance with statue and policy guidance, the program's research has targeted the sciences of wind turbine dynamics and the development of advanced components and systems. Wind turbine research has focused on atmospheric fluid dynamics, aerodynamics, and structural dynamics. Rating factors including project scientific and technical merit, appropriateness and level of innovation of the technical approach, quality of the project team, productivity, and probable impact on the program's mission. Each project was also given an overall evaluation supported with written comments.

  10. Progress on the accelerator based SPES-BNCT project at INFN Legnaro

    Science.gov (United States)

    Esposito, J.; Colautti, P.; Pisent, A.; De Nardo, L.; Conte, V.; Moro, D.; Agosteo, S.; Jori, G.; Tinti, R.; Rosi, G.

    2007-02-01

    In the framework of an advanced Exotic Ion Beam facility, named SPES (Study and Production of Exotic Species), that will allow a frontier program both in nuclear and interdisciplinary physics, an intense thermal neutron beam facility, devoted to perform Boron Neutron Capture Therapy (BNCT) experimental treatments on skin melanoma tumor, is currently under construction based on the SPES proton driver. A vast radiobiological investigation in vitro and in vivo has started with the new 10B carriers developed. Special microdosimetric detectors have been constructed to properly measure all the BNCT dose components and their qualities. Both microdosimetric and radiobiological measurements are being performed at the new HYTHOR beam shaping assembly at the Enea-Casaccia TAPIRO reactor.

  11. Carborane-containing metalloporphyrins for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Michiko; Joel, D.D.; Nawrocky, M.M.; Micca, P.L. [and others

    1996-12-31

    For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be possible if ratios of {sup 10}B concentrations in tumor to those in normal tissue (e.g. brain and blood) were at least 5: 1. Given that the only current boron carrier being tested clinically in the U.S., p-boronophenyl-alanine[BPA], yields tumor blood and tumor brain ratios of about 3:1, the criteria for new boronated compounds should be to at least match these ratios and maintain tumor boron concentrations greater than 30 {mu}g B/g. Although previously tested boronated porphyrins have not only matched but surpassed these ratios, it was at a cost of greater toxicity. Chemical and hematological assays of blood analytes; showed marked thrombocytopenia, a decrease to about one-tenth the normal concentration of platelets circulating in the blood, in addition to abnormalities in concentrations of circulating enzymes, that indicated liver toxicity. The physical appearance and behavior of the affected mice were different from those of mice injected with solvent only. Although thrombocytopenia and other toxic effects had disappeared after a few days, previously tested porphyrins would not be safe to infuse into patients for BNCT of potentially hemorrhagic malignant tumors in the brain such as glioblastoma multiforme and metastatic melanoma. We synthesized a different boronated porphyrin, tetracarboranylphenylporphyrin, [TCP] and inserted nickel, copper, or manganese into its coordination center. Biological studies of NiTCP in mice and of CuTCP in rats show that these compounds elicit little or no toxicity when given at potentially therapeutic doses.

  12. NCI: DCTD: Biometric Research Program

    Science.gov (United States)

    The Biometric Research Program (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

  13. Cleveland Clinic Rehabilitation Research Program

    Science.gov (United States)

    2014-10-01

    functional impairments of the arm and hand , effects are weak and invariable. Limited succcess of rehabilitation is speculated to be associated with...Award Number: W81XWH-11-1-0707 TITLE: Cleveland Clinic Rehabilitation Research Program PRINCIPAL INVESTIGATOR: Vernon Lin, MD PhD CONTRACTING...CONTRACT NUMBER Cleveland Clinic Rehabilitation Research Program 5b. GRANT NUMBER W81XWH-11-1-0707 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  14. Ecological Research Division, Marine Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States.

  15. Evaluation of the effective dose during BNCT at TRR thermal column epithermal facility.

    Science.gov (United States)

    Jarahi, Hossein; Kasesaz, Yaser; Saleh-Koutahi, Seyed Mohsen

    2016-04-01

    An epithermal neutron beam has been designed for Boron neutron Capture Therapy (BNCT) at the thermal column of Tehran Research Reactor (TRR) recently. In this paper the whole body effective dose, as well as the equivalent doses of several organs have been calculated in this facility using MCNP4C Monte Carlo code. The effective dose has been calculated by using the absorbed doses determined for each individual organ, taking into account the radiation and tissue weighting factors. The ICRP 110 whole body male phantom has been used as a patient model. It was found that the effective dose during BNCT of a brain tumor is equal to 0.90Sv. This effective dose may induce a 4% secondary cancer risk.

  16. An accelerator-based epithermal photoneutron source for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Nigg, D.W.; Mitchell, H.E.; Harker, Y.D.; Yoon, W.Y. [and others

    1995-11-01

    Therapeutically-useful epithermal-neutron beams for BNCT are currently generated by nuclear reactors. Various accelerator-based neutron sources for BNCT have been proposed and some low intensity prototypes of such sources, generally featuring the use of proton beams and beryllium or lithium targets have been constructed. This paper describes an alternate approach to the realization of a clinically useful accelerator-based source of epithermal neutrons for BNCT that reconciles the often conflicting objectives of target cooling, neutron beam intensity, and neutron beam spectral purity via a two stage photoneutron production process.

  17. Human Research Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Strategically, the HRP conducts research and technology development that: 1) enables the development or modification of Agency-level human health and performance...

  18. Tansmutation Research program

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Paul

    2011-07-31

    Six years of research was conducted for the United States Department of Energy, Office of Nuclear Energy between the years of 2006 through 2011 at the University of Nevada, Las Vegas (UNLV). The results of this research are detailed in the narratives for tasks 1-45. The work performed spanned the range of experimental and modeling efforts. Radiochemistry (separations, waste separation, nuclear fuel, remote sensing, and waste forms) , material fabrication, material characterization, corrosion studies, nuclear criticality, sensors, and modeling comprise the major topics of study during these six years.

  19. Concept of a BNCT line with in-pool fission converter at MARIA reactor in Swierk

    Science.gov (United States)

    Pytel, Krzysztof; Andrzejewski, Krzysztof; Golnik, Natalia; Osko, Jakub

    2009-01-01

    BNCT facility in the Institute of Atomic Energy in Otwock-Swierk is under construction at the horizontal channel H2 of the research reactor MARIA. Measurements of the neutron energy spectrum performed at the front of the H2 experimental channel, have shown that flux of epithermal neutrons (above 10 keV) at the BNCT irradiation port was below 109 n cm-2 s-1 i.e. it was too low to be directly used for the BNCT treatment. Therefore, a fission converter will be placed between the reactor core and the periphery of the graphite reflector of MARIA reactor. The uranium converter will be powered by the densely packed EK-10 fuel elements with 10% enrichment. Preliminary calculations have shown that the total neutron flux in the converter will be about 1013 n cm-2 s-1 and flux of epithermal neutrons at the entrance to the filter/moderator of the beam will be about 2·1013 n cm-2 s-1.

  20. International Arctic Research Programs

    Science.gov (United States)

    1989-07-01

    our re- 27 Demand for multi-disciplinary of the boreal forest zone -, should discuss the feazibility of establishing a mechanism Scientific Cooperation...interactions, very low frequency waves, auroras , and precipitation of energetic particles from the mag- netosphere. Ocean Sciences research has...vestigating the aurora phenomenon, which can have a severe impact on communications, and the dynamics of the upper atmosphere, including the arctic

  1. Fermilab research Program 1976

    Energy Technology Data Exchange (ETDEWEB)

    Lach, J., (Ed.); /Fermilab

    1976-01-01

    This collection of one-page summaries of Fermilab proposals is intended to serve as a way station between the experiment number with its short title and the full proposal. It is not intended to be a review of the Fermilab experimental program. Just as an abstract of a journal article embodies the main points of the article, so these one-page summaries are intended to convey the major points of a proposal. These should include its physics justification, a brief description of the apparatus and the demands that the experiment will make on the Laboratory. Of course these summaries are not intended to take the place of the proposal itself which is the primary document available in the Fermilab library and at SLAC, BNL and CERN. Individual copies should be obtained from the spokesman of the experiment whose name is underlined in these summaries. Summaries for all experiments and pending proposals are included. These comprise approved, unconsidered and deferred proposals. Rejected, withdrawn and inactive proposals are not included. It is the experimenters themselves who are best able to write the summary and in most cases that is what was done. For the early proposals and those cases where repeated cajoling could not produce one from the experimenters, the summary was prepared by a Fermilab staff member and then sent to the spokesman for comment. All proposals submitted before the May 7, 1976 deadline for consideration at the extended summer meeting of our Program Advisory Committee are included. It is not intended that this volume be updated annually but perhaps only reissued when the previous ones becomes hopelessly obsolete.

  2. NASA's computer science research program

    Science.gov (United States)

    Larsen, R. L.

    1983-01-01

    Following a major assessment of NASA's computing technology needs, a new program of computer science research has been initiated by the Agency. The program includes work in concurrent processing, management of large scale scientific databases, software engineering, reliable computing, and artificial intelligence. The program is driven by applications requirements in computational fluid dynamics, image processing, sensor data management, real-time mission control and autonomous systems. It consists of university research, in-house NASA research, and NASA's Research Institute for Advanced Computer Science (RIACS) and Institute for Computer Applications in Science and Engineering (ICASE). The overall goal is to provide the technical foundation within NASA to exploit advancing computing technology in aerospace applications.

  3. Jointly Sponsored Research Program Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2009-03-31

    Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental

  4. Nebraska Prostate Cancer Research Program

    Science.gov (United States)

    2015-10-01

    Annual National Symposium on Prostate Cancer by CCRTD, CAU, March 16-19, 2014. 15. Appendix #15: Peer- reviewed scientific publication with inputs...and  Immunology Y. Tu CU Regulation of G‐Protein‐Coupled  Receptors in Prostate  Cancer     Acknowledgements: DOD CDMRP PCa Research Program PC121645...AWARD NUMBER: W81XWH-13-1-0264 TITLE: Nebraska Prostate Cancer Research Program PRINCIPAL INVESTIGATOR: Ming-Fong Lin, Ph.D

  5. Deployment Related Medical Research Program

    Science.gov (United States)

    2010-12-01

    including face, visual/ocular, and nerve damage; dental ; and auditory systems) Deployment Related Medical Research Program4 DRMRP Research Gaps Together...healing • Approaches to prevention or treatment of bone infections • Methods and technologies for prevention of the formation of bacterial biofilms in...from combat injuries, and biocompatible craniofacial implants for use in craniofacial reconstruction due to combat trauma • Characterization of

  6. Computational dosimetry of a simulated combined standard X-Rays and BNCT treatment

    Energy Technology Data Exchange (ETDEWEB)

    Casal, M.R., E-mail: mcasal@cnea.gov.ar [Instituto de Oncologia ' Angel H. Roffo' , Universidad de Buenos Aires, Av. San Martin 5481, Bs.As. (Argentina)] [Comision Nacional de Energia Atomica, Av. General Paz 1499, San Martin, Buenos Aires (Argentina); Herrera, M.S., E-mail: mariettaherrera@gmail.com [Comision Nacional de Energia Atomica, Av. General Paz 1499, San Martin, Buenos Aires (Argentina)] [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Av. Rivadavia 191, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad de General San Martin, 25 de Mayo and M. de Irigoyen, San Martin (Argentina); Gonzalez, S.J., E-mail: srgonzal@cnea.gov.ar [Comision Nacional de Energia Atomica, Av. General Paz 1499, San Martin, Buenos Aires (Argentina)] [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Av. Rivadavia 191, Buenos Aires (Argentina)

    2011-12-15

    There has been increasing interest in combining Boron Neutron Capture Therapy (BNCT) with standard radiotherapy, either concomitantly or as a BNCT treatment of a recurrent tumor that was previously irradiated with a medical electron linear accelerator (LINAC). In this work we report the simulated dosimetry of treatments combining X-rays and BNCT

  7. Clean Coal Program Research Activities

    Energy Technology Data Exchange (ETDEWEB)

    Larry Baxter; Eric Eddings; Thomas Fletcher; Kerry Kelly; JoAnn Lighty; Ronald Pugmire; Adel Sarofim; Geoffrey Silcox; Phillip Smith; Jeremy Thornock; Jost Wendt; Kevin Whitty

    2009-03-31

    Although remarkable progress has been made in developing technologies for the clean and efficient utilization of coal, the biggest challenge in the utilization of coal is still the protection of the environment. Specifically, electric utilities face increasingly stringent restriction on the emissions of NO{sub x} and SO{sub x}, new mercury emission standards, and mounting pressure for the mitigation of CO{sub 2} emissions, an environmental challenge that is greater than any they have previously faced. The Utah Clean Coal Program addressed issues related to innovations for existing power plants including retrofit technologies for carbon capture and sequestration (CCS) or green field plants with CCS. The Program focused on the following areas: simulation, mercury control, oxycoal combustion, gasification, sequestration, chemical looping combustion, materials investigations and student research experiences. The goal of this program was to begin to integrate the experimental and simulation activities and to partner with NETL researchers to integrate the Program's results with those at NETL, using simulation as the vehicle for integration and innovation. The investigators also committed to training students in coal utilization technology tuned to the environmental constraints that we face in the future; to this end the Program supported approximately 12 graduate students toward the completion of their graduate degree in addition to numerous undergraduate students. With the increased importance of coal for energy independence, training of graduate and undergraduate students in the development of new technologies is critical.

  8. Feasibility of BNCT radiobiological experiments at the HYTHOR facility

    Science.gov (United States)

    Esposito, J.; Ceballos, C.; Soncin, M.; Fabris, C.; Friso, E.; Moro, D.; Colautti, P.; Jori, G.; Rosi, G.; Nava, E.

    2008-06-01

    HYTHOR (HYbrid Thermal spectrum sHifter tapirO Reactor) is a new thermal-neutron irradiation facility, which was installed and became operative in mid 2005 at the TAPIRO (TAratura PIla Rapida potenza 0) fast reactor, in the Casaccia research centre (near Rome) of ENEA (Ente per le Nuove tecnologie Energia ed Ambiente). The facility has been designed for in vivo radiobiological studies. In HYTHOR irradiation cavity, 1-6 mice can be simultaneously irradiated to study skin melanoma treatments with the BNCT (boron neutron capture therapy). The therapeutic effects of HYTHOR radiation field on mouse melanoma has been studied as a preliminary investigation before studying the tumour local control due to boron neutron capture effect after boronated molecule injection. The method to properly irradiate small animals has been precisely defined. Results show that HYTHOR radiation field is by itself effective in reducing the tumour-growth rate. This finding has to be taken into account in studying the effectiveness of new 10B carriers. A method to properly measure the reduction of the tumour-growth rate is reported and discussed.

  9. Dose masking feature for BNCT radiotherapy planning

    Science.gov (United States)

    Cook, Jeremy L.; Wessol, Daniel E.; Wheeler, Floyd J.

    2000-01-01

    A system for displaying an accurate model of isodoses to be used in radiotherapy so that appropriate planning can be performed prior to actual treatment on a patient. The nature of the simulation of the radiotherapy planning for BNCT and Fast Neutron Therapy, etc., requires that the doses be computed in the entire volume. The "entire volume" includes the patient and beam geometries as well as the air spaces in between. Isodoses derived from the computed doses will therefore extend into the air regions between the patient and beam geometries and thus depict the unrealistic possibility that radiation deposition occurs in regions containing no physical media. This problem is solved by computing the doses for the entire geometry and then masking the physical and air regions along with the isodose contours superimposed over the patient image at the corresponding plane. The user is thus able to mask out (remove) the contour lines from the unwanted areas of the image by selecting the appropriate contour masking region from the raster image.

  10. Protocols for BNCT of glioblastoma multiforme at Brookhaven: Practical considerations

    Energy Technology Data Exchange (ETDEWEB)

    Chanana, A.D.; Coderre, J.A.; Joel, D.D.; Slatkin, D.N.

    1996-12-31

    In this report we discuss some issues considered in selecting initial protocols for boron neutron capture therapy (BNCT) of human glioblastoma multiforme. First the tolerance of normal tissues, especially the brain, to the radiation field. Radiation doses limits were based on results with human and animal exposures. Estimates of tumor control doses were based on the results of single-fraction photon therapy and single fraction BNCT both in humans and experimental animals. Of the two boron compounds (BSH and BPA), BPA was chosen since a FDA-sanctioned protocol for distribution in humans was in effect at the time the first BNCT protocols were written and therapy studies in experimental animals had shown it to be more effective than BSH.

  11. Organisation and management of the first clinical trial of BNCT in Europe (EORTC protocol 11961).EORTC BNCT study group.

    Science.gov (United States)

    Sauerwein, W; Moss, R; Rassow, J; Stecher-Rasmussen, F; Hideghéty, K; Wolbers, J G; Sack, H

    1999-06-01

    Boron Neutron Capture Therapy is based on the ability of the isotope 10B to capture thermal neutrons and to disintegrate instantaneously producing high LET particles. The only neutron beam available in Europe for such a treatment is based at the European High Flux Reactor HFR at Petten (The Netherlands). The European Commission, owners of the reactor, decided that the potential benefit of the facility should be opened to all European citizens and therefore insisted on a multinational approach to perform the first clinical trial in Europe on BNCT. This precondition had to be respected as well as the national laws and regulations. Together with the Dutch authorities actions were undertaken to overcome the obvious legal problems. Furthermore, the clinical trial at Petten takes place in a nuclear research reactor, which apart from being conducted in a non-hospital environment, is per se known to be dangerous. It was therefore of the utmost importance that special attention is given to safety, beyond normal rules, and to the training of staff. In itself, the trial is an unusual Phase I study, introducing a new drug with a new irradiation modality, with really an unknown dose-effect relationship. This trial must follow optimal procedures, which underscore the quality and qualified manner of performance.

  12. The new hybrid thermal neutron facility at TAPIRO reactor for BNCT radiobiological experiments.

    Science.gov (United States)

    Esposito, J; Rosi, G; Agosteo, S

    2007-01-01

    A new thermal neutron irradiation facility, devoted to carry out both dosimetric and radiobiological studies on boron carriers, which are being developed in the framework of INFN BNCT project, has been installed at the ENEA Casaccia TAPIRO research fast reactor. The thermal column, based on an original, hybrid, neutron spectrum shifter configuration, has been recently become operative. In spite of its low power (5 kW), the new facility is able to provide a high thermal neutron flux level, uniformly distributed inside the irradiation cavity, with a quite low gamma background. The main features and preliminary benchmark measurements of the Beam-shaping assembly are here presented and discussed.

  13. Cooperative IASCC Research (CIR) Program

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, J.L. [Electric Power Research Inst., Palo Alto, CA (United States). Nuclear Power Group

    1998-03-01

    Irradiation assisted stress corrosion cracking (IASCC) describes intergranular environmental cracking of material exposed to ionizing radiation. The implications of IASCC are significant, both in terms of repair and outage costs as well as the potential for cracking in components that may be extremely difficult to repair or replace. Significant advancements have been made in the understanding of IASCC. However, it is clear that major unknowns persist and must be understood and quantified before the life of a reactor component at risk from IASCC can be predicted or significantly extended. Although individual organizations are continuing to effectively address IASCC, it became apparent that a more direct form of cooperation would be more timely and efficient in addressing the technical issues. Thus in 1995 EPRI formed the Cooperative IASCC Research (CIR) Program. This is a cooperative, jointly funded effort with participants from eight countries providing financial support and technical oversight. The efforts of the CIR Program are directed at the highest priority questions in the areas of material susceptibility, water chemistry and material stress. Major research areas of the Program are: (1) evaluation of IASCC mechanisms, (2) development of methodology for predicting IASCC, and (3) quantification of irradiation effects on metallurgy, mechanics and electrochemistry. Studies to evaluate various IASCC mechanisms include work to better understand the possible roles of radiation-induced segregation (RIS), radiation microstructure, bulk and localized deformation effects, overall effects on strength and ductility, hydrogen and helium effects, and others. Experiments are being conducted to isolate individual effects and determine the relative importance of each in the overall IASCC mechanism. Screening tests will be followed by detailed testing to identify the contribution of each effect over a range of conditions. The paper describes the completed and ongoing work being

  14. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.); Dorn, R.V. III.

    1990-08-01

    This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, noninvasive boron quantitative determination, analytical radiation transport and interaction modeling for BNCT, large animal model studies, neutron source and facility preparation, administration and common support and PBF operations.

  15. 124Sb-Be photo-neutron source for BNCT: Is it possible?

    Science.gov (United States)

    Golshanian, Mohadeseh; Rajabi, Ali Akbar; Kasesaz, Yaser

    2016-11-01

    In this research a computational feasibility study has been done on the use of 124SbBe photo-neutron source for Boron Neutron Capture Therapy (BNCT) using MCNPX Monte Carlo code. For this purpose, a special beam shaping assembly has been designed to provide an appropriate epithermal neutron beam suitable for BNCT. The final result shows that using 150 kCi of 124Sb, the epithermal neutron flux at the designed beam exit is 0.23×109 (n/cm2 s). In-phantom dose analysis indicates that treatment time for a brain tumor is about 40 min which is a reasonable time. This high activity 124Sb could be achieved using three 50 kCi rods of 124Sb which can be produced in a research reactor. It is clear, that as this activity is several hundred times the activity of a typical cobalt radiotherapy source, issues related to handling, safety and security must be addressed.

  16. Experimental and theoretical evaluation of accelerator based epithermal neutron yields for BNCT

    Science.gov (United States)

    Wielopolski, L.; Ludewig, H.; Powell, J. R.; Raparia, D.; Alessi, J. G.; Alburger, D. E.; Zucker, M. S.; Lowenstein, D. I.

    1999-06-01

    At BNL, we have evaluated the beam current required to produce a clinical neutron beam for Boron Neutron Capture Therapy (BNCT) with an epithermal neutron flux of 1012n/cm2/hr. Experiments were carried out on a Van de Graaff accelerator at the Radiological Research Accelerator Facility (RARAF) at Columbia University. A thick Li target was irradiated by protons with energies from 1.8 to 2.5 MeV. The neutron spectra resulting from the 7Li(p,n)7Be reaction, followed by various filter configurations, were determined by measuring pulse height distributions with a gas filled proton recoil spectrometer. These distributions were unfolded into neutron energy spectra using the PSNS code, from which the required beam currents were estimated to be about 5 mA. Results are in good agreement with calculations using the MCNP-4A transport code. In addition comparison was also made between the neutron flux obtained at the Brookhaven Medical Research Reactor (where clinical trials of BNCT are ongoing), and measurements at RARAF, using a 10BF3 detector in a phantom. These results also support the requirement for about 5 mA beam current.

  17. Human Research Program Exploration Medical Capability

    Science.gov (United States)

    Barsten, Kristina

    2010-01-01

    NASA s Human Research Program (HRP) conducts and coordinates research projects that provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Program is divided into 6 major elements, which a) Provide the Program s knowledge and capabilities to conduct research, addressing the human health and performance risks. b) Advance the readiness levels of technology and countermeasures to the point of transfer to the customer programs and organizations. The National Space Biomedical Research Institute (NSBRI) is a partner with the HRP in developing a successful research program. 3

  18. Design of a beam shaping assembly and preliminary modelling of a treatment room for accelerator-based BNCT at CNEA

    Energy Technology Data Exchange (ETDEWEB)

    Burlon, A.A.; Girola, S. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Valda, A.A., E-mail: valda@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina); Minsky, D.M.; Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, Comision Nacional de Energia Atomica, San Martin (Argentina)] [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)] [CONICET, Buenos Aires (Argentina); Sanchez, G. [Escuela de Ciencia y Tecnologia, Universidad Nacional de San Martin, San Martin (Argentina)

    2011-12-15

    This work reports on the characterisation of a neutron beam shaping assembly (BSA) prototype and on the preliminary modelling of a treatment room for BNCT within the framework of a research programme for the development and construction of an accelerator-based BNCT irradiation facility in Buenos Aires, Argentina. The BSA prototype constructed has been characterised by means of MCNP simulations as well as a set of experimental measurements performed at the Tandar accelerator at the National Atomic Energy Commission of Argentina. - Highlights: Black-Right-Pointing-Pointer Characterisation of a neutron beam shaping assembly for accelerator-based BNCT. Black-Right-Pointing-Pointer Measurements: total and epi-cadmium neutron fluxes and beam homogeneity. Black-Right-Pointing-Pointer Calculations: Monte Carlo simulations with the MCNP code. Black-Right-Pointing-Pointer Measured and calculated figure-of-merit parameters in agreement with those of IAEA. Black-Right-Pointing-Pointer Initial MCNP dose calculations for a treatment room to define future design actions.

  19. Joint Assessment of ETRR-2 Research Reactor Operations Program, Capabilities, and Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bissani, M; O' Kelly, D S

    2006-05-08

    A joint assessment meeting was conducted at the Egyptian Atomic Energy Agency (EAEA) followed by a tour of Egyptian Second Research Reactor (ETRR-2) on March 22 and 23, 2006. The purpose of the visit was to evaluate the capabilities of the new research reactor and its operations under Action Sheet 4 between the U.S. DOE and the EAEA, ''Research Reactor Operation'', and Action Sheet 6, ''Technical assistance in The Production of Radioisotopes''. Preliminary Recommendations of the joint assessment are as follows: (1) ETRR-2 utilization should be increased by encouraging frequent and sustained operations. This can be accomplished in part by (a) Improving the supply-chain management for fresh reactor fuel and alleviating the perception that the existing fuel inventory should be conserved due to unreliable fuel supply; and (b) Promulgating a policy for sample irradiation priority that encourages the use of the reactor and does not leave the decision of when to operate entirely at the discretion of reactor operations staff. (2) Each experimental facility in operation or built for a single purpose should be reevaluated to focus on those that most meet the goals of the EAEA strategic business plan. Temporary or long-term elimination of some experimental programs might be necessary to provide more focused utilization. There may be instances of emerging reactor applications for which no experimental facility is yet designed or envisioned. In some cases, an experimental facility may have a more beneficial use than the purpose for which it was originally designed. For example, (a) An effective Boron Neutron Capture Therapy (BNCT) program requires nearby high quality medical facilities. These facilities are not available and are unlikely to be constructed near the Inshas site. Further, the BNCT facility is not correctly designed for advanced research and therapy programs using epithermal neutrons. (b) The ETRR-2 is frequently operated to

  20. Procedural and practical applications of radiation measurements for BNCT at the HFR Petten

    Science.gov (United States)

    Moss, R. L.; Stecher-Rasmussen, F.; Rassow, J.; Morrissey, J.; Voorbraak, W.; Verbakel, W.; Appelman, K.; Daquino, G. G.; Muzi, L.; Wittig, A.; Bourhis-Martin, E.; Sauerwein, W.

    2004-01-01

    Since October 1997, a clinical trial of Boron Neutron Capture Therapy (BNCT) for glioblastoma patients has been in progress at the High Flux Reactor, Petten, the Netherlands. The trial is a European Organisation for Research and Treatment of Cancer (EORTC) protocol (#11 961) and, as such, must be conducted following the highest quality management and procedures, according to good clinical practice and also other internationally accepted codes. The complexity of BNCT involves not only strict international procedures, but also a variety of techniques to measure the different aspects of the irradiation involved when treating the patient. Applications include: free beam measurements using packets of activation foils; in-phantom measurements for beam calibration using ionisation chambers, pn-diodes and activation foils; monitoring of the irradiation beam during patient treatment using fission chambers and GM-counters; boron in blood measurements using prompt gamma ray spectroscopy; radiation protection of the patient and staff using portable radiation dosimeters and personal dosimeters; and in vivo measurements of the boron in the patient using a prompt gamma ray telescope. The procedures and applications of such techniques are presented here, with particular emphasis on the importance of the quality assurance/quality control procedures and its reporting.

  1. Resumption of JRR-4 and characteristics of neutron beam for BNCT.

    Science.gov (United States)

    Nakamura, T; Horiguchi, H; Kishi, T; Motohashi, J; Sasajima, F; Kumada, H

    2011-12-01

    The clinical trials of Boron Neutron Capture Therapy (BNCT) have been conducted using Japan Research Reactor No. 4 (JRR-4) at Japan Atomic Energy Agency (JAEA). On December 28th, 2007, a crack of a graphite reflector in the reactor core was found on the weld of the aluminum cladding. For this reason, specifications of graphite reflectors were renewed; dimensions of the graphite were reduced and gaps of water were increased. All existing graphite reflectors of JRR-4 were replaced by new graphite reflectors. In February 2010 the resumption of JRR-4 was carried out with new graphite reflectors. We measured the characteristics of neutron beam at the JRR-4 Neutron Beam Facility. A cylindrical water phantom of 18.6 cm diameter and 24 cm depth was set in front of the beam port with 1cm gap. TLDs and gold wires were inserted within the phantom when the phantom was irradiated. The results of the measured thermal neutron flux and the gamma dose in water were compared with that of MCNP calculation. The neutron energy spectrum of the calculation model with new reflector had little variation compared to that with old reflector, but intensities of the neutron flux and gamma dose with new reflector were rather smaller than those with old reflector. The calculated results showed the same tendency as that of the experimental results. Therefore, the clinical trials of BNCT in JRR-4 could be restarted.

  2. AERA Research Training Program 1969. Final Report.

    Science.gov (United States)

    Popham, W. James

    This report describes and evaluates a training program for educational researchers conducted prior to and following the 1969 annual meeting of the American Educational Research Association. The report's description of each of the program's 12 specific training sessions, which served a total of 542 educational researchers, includes the following…

  3. Dose factor entry and display tool for BNCT radiotherapy

    Science.gov (United States)

    Wessol, Daniel E.; Wheeler, Floyd J.; Cook, Jeremy L.

    1999-01-01

    A system for use in Boron Neutron Capture Therapy (BNCT) radiotherapy planning where a biological distribution is calculated using a combination of conversion factors and a previously calculated physical distribution. Conversion factors are presented in a graphical spreadsheet so that a planner can easily view and modify the conversion factors. For radiotherapy in multi-component modalities, such as Fast-Neutron and BNCT, it is necessary to combine each conversion factor component to form an effective dose which is used in radiotherapy planning and evaluation. The Dose Factor Entry and Display System is designed to facilitate planner entry of appropriate conversion factors in a straightforward manner for each component. The effective isodose is then immediately computed and displayed over the appropriate background (e.g. digitized image).

  4. Boron concentration measurement system for the Czech BNCT project

    Science.gov (United States)

    Honzátko, J.; Tomandl, I.

    2000-07-01

    In the framework of the Czech Boron Neutron Capture Therapy (BNCT) project a Prompt Gamma Ray Analysis (PGRA) facility for the determination of the boron concentration in biological samples was built at light-water reactor at Řež. The facility utilizes the beam of thermal neutrons from a neutron guide. The pure beam of thermal neutrons and background conditions enables the determination of 1 ppm with the reasonable statistical error 5% within 15 minutes.

  5. Positron emission tomography and [{sup 18}F]BPA: A perspective application to assess tumour extraction of boron in BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Menichetti, L. [Department of PET and Radiopharmaceutical Chemistry, C.N.R. Institute of Clinical Physiology, Pisa (Italy)], E-mail: luca.menichetti@ifc.cnr.it; Cionini, L. [Unit of Radiotherapy, AOUP-University Hospital, Pisa (Italy); Sauerwein, W.A. [Department of Radiation Oncology, University Duisburg-Essen, University Hospital Essen (Germany); Altieri, S. [University of Pavia, Department of Nuclear Physics, Pavia (Italy); Solin, O.; Minn, H. [Turku PET Centre, University of Turku (Finland); Salvadori, P.A. [Department of PET and Radiopharmaceutical Chemistry, C.N.R. Institute of Clinical Physiology, Pisa (Italy)

    2009-07-15

    Positron emission tomography (PET) has become a key imaging tool in clinical practice and biomedical research to quantify and study biochemical processes in vivo. Physiologically active compounds are tagged with positron emitters (e.g. {sup 18}F, {sup 11}C, {sup 124}I) while maintaining their biological properties, and are administered intravenously in tracer amounts (10{sup -9}-10{sup -12} M quantities). The recent physical integration of PET and computed tomography (CT) in hybrid PET/CT scanners allows a combined anatomical and functional imaging: nowadays PET molecular imaging is emerging as powerful pharmacological tool in oncology, neurology and for treatment planning as guidance for radiation therapy. The in vivo pharmacokinetics of boron carrier for BNCT and the quantification of {sup 10}B in living tissue were performed by PET in the late nineties using compartmental models based on PET data. Nowadays PET and PET/CT have been used to address the issue of pharmacokinetic, metabolism and accumulation of BPA in target tissue. The added value of the use of L-[{sup 18}F]FBPA and PET/CT in BNCT is to provide key data on the tumour extraction of {sup 10}B-BPA versus normal tissue and to predict the efficacy of the treatment based on a single-study patient analysis. Due to the complexity of a binary treatment like BNCT, the role of PET/CT is currently to design new criteria for patient enrolment in treatment protocols: the L-[{sup 18}F]BPA/PET methodology could be considered as an important tool in newly designed clinical trials to better estimate the concentration ratio of BPA in the tumour as compared to neighbouring normal tissues. Based on these values for individual patients the decision could be made whether BNCT treatment could be advantageous due to a selective accumulation of BPA in an individual tumour. This approach, applicable in different tumour entities like melanoma, glioblastoma and head and neck malignancies, make this methodology as reliable

  6. Boron Neutron Capture Therapy at the TRIGA Mark II of Pavia, Italy - The BNCT of the diffuse tumours

    Energy Technology Data Exchange (ETDEWEB)

    Altieri, S.; Bortolussi, S.; Stella, S.; Bruschi, P.; Gadan, M.A. [University of Pavia (Italy); INFN - National Institute for Nuclear Physics, of Pavia (Italy)

    2008-10-29

    The selectivity based on the B distribution rather than on the irradiation field makes Boron neutron Capture Therapy (BNCT) a valid option for the treatment of the disseminated tumours. As the range of the high LET particles is shorter than a cell diameter, the normal cells around the tumour are not damaged by the reactions occurring in the tumoral cells. PAVIA 2001: first treatment of multiple hepatic metastases from colon ca by BNCT and auto-transplantation technique: TAOrMINA project. The liver was extracted after BPA infusion, irradiated in the Thermal Column of the Pavia TRIGA Mark II reactor, and re-implanted in the patient. Two patients were treated, demonstrating the feasibility of the therapy and the efficacy in destroying the tumoral nodules sparing the healthy tissues. In the last years, the possibility of applying BNCT to the lung tumours using epithermal collimated neutron beams and without explanting the organ, is being explored. The principal obtained results of the BNCT research are presented, with particular emphasis on the following aspects: a) the project of a new thermal column configuration to make the thermal neutron flux more uniform inside the explanted liver, b) the Monte Carlo study by means of the MCNP code of the thermal neutron flux distribution inside a patient's thorax irradiated with epithermal neutrons, and c) the measurement of the boron concentration in tissues by (n,{alpha}) spectroscopy and neutron autoradiography. The dose distribution in the thorax are simulated using MCNP and the anthropomorphic model ADAM. To have a good thermal flux distribution inside the lung epithermal neutrons must be used, which thermalize crossing the first tissue layers. Thermal neutrons do not penetrate and the obtained uniformity is poor. In the future, the construction of a PGNAA facility using a horizontal channel of the TRIGA Mark II is planned. With this method the B concentration can be measured also in liquid samples (blood, urine) and

  7. Clinical results of BNCT for malignant brain tumors in children

    Energy Technology Data Exchange (ETDEWEB)

    Nakagawa, Yoshinobu [Department of Neurosurgery, Kagawa National Children' s Hospital, Kagawa 765-8501 (Japan)], E-mail: ynakagawa0517@yahoo.co.jp; Kageji, Teruyoshi; Mizobuchi, Yoshifumi [Department of Neurosurgery, University of Tokushima, Tokushima 770-8503 (Japan); Kumada, Hiroaki [Department of Research Reactor, Japan Atomic Energy Research Institute, Ibaragi 319-1195 (Japan); Nakagawa, Yoshiaki [Department of Medical Informatics, Post Graduated School, Kyoto University, Kyoto (Japan)

    2009-07-15

    It is very difficult to treat the patients with malignant brain tumor in children, especially under 3 years, because the conventional irradiation cannot be applied due to the damage of normal brain tissue. However, boron neutron capture therapy (BNCT) has tumor selectivity such that it can make damage only in tumor cells. We evaluated the clinical results and courses in patients with malignant glioma under 15 years. Among 183 patients with brain tumors treated by our group using BSH-based intra-operative BNCT, 23 patients were under 15 years. They included 4 patients under 3 years. There were 3 glioblastomas (GBM), 6 anaplastic astrocytomas(AAS), 7 primitive neuroectodermal tumors (PNET), 6 pontine gliomas and 1 anaplastic ependymoma. All GBM and PNET patients died due to CSF and/or CNS dissemination without local tumor regrowth. All pontine glioma patients died due to regrowth of the tumor. Four of 6 anaplastic astrocytoma and 1 anaplastic ependymoma patients alive without tumor recurrence. BNCT can be applied to malignant brain tumors in children, especially under 3 years instead of conventional radiation. Although it can achieve the local control in the primary site, it cannot prevent CSF dissemination in patients with glioblastoma.

  8. Nebraska Prostate Cancer Research Program

    Science.gov (United States)

    2014-07-01

    2011.  LaTayia Aaron and Joann Powell. (2012). Dioxin exposure enhances nuclear localization of androgen receptor...to be trained in different areas of prostate cancer research. For example, the focus areas or research include Biomarkers , Therapy, Genetics, and...example, the focus areas or research include Biomarkers , Therapy, Genetics, and Tumor Biology as outlined by the laboratory research descriptions in the

  9. Evaluating the BK 21 Program. Research Brief

    Science.gov (United States)

    Seong, Somi; Popper, Steven W.; Goldman, Charles A.; Evans, David K.; Grammich, Clifford A.

    2008-01-01

    The Brain Korea 21 program (BK21), an effort to improve Korean universities and research, has attracted a great deal of attention in Korea, producing the need to understand how well the program is meeting its goals. RAND developed a logic model for identifying program goals and dynamics, suggested quantitative and qualitative evaluation methods,…

  10. Boron neutron capture therapy (BNCT) for liver metastasis: therapeutic efficacy in an experimental model

    Energy Technology Data Exchange (ETDEWEB)

    David W. Nigg

    2012-08-01

    Boron neutron capture therapy (BNCT) was proposed for untreatable colorectal liver metastases. The present study evaluates tumor control and potential radiotoxicity of BNCT in an experimental model of liver metastasis. BDIX rats were inoculated with syngeneic colon cancer cells DHD/K12/TRb. Tumor-bearing animals were divided into three groups: BPA–BNCT, boronophenylalanine (BPA) ? neutron irradiation; Beam only, neutron irradiation; Sham, matched manipulation. The total absorbed dose administered with BPA–BNCT was 13 ± 3 Gy in tumor and 9 ± 2 Gy in healthy liver. Three weeks posttreatment, the tumor surface area post-treatment/pre-treatment ratio was 0.46 ± 0.20 for BPA–BNCT, 2.7 ± 1.8 for Beam only and 4.5 ± 3.1 for Sham. The pre-treatment tumor nodule mass of 48 ± 19 mgfell significantly to 19 ± 16 mg for BPA–BNCT, but rose significantly to 140 ± 106 mg for Beam only and to 346 ± 302 mg for Sham. For both end points, the differences between the BPA–BNCT group and each of the other groups were statistically significant (ANOVA). No clinical, macroscopic or histological normal liver radiotoxicity was observed. It is concluded that BPA– BNCT induced a significant remission of experimental colorectal tumor nodules in liver with no contributory liver toxicity.

  11. Extreme Programming in a Research Environment

    Science.gov (United States)

    Wood, William A.; Kleb, William L.

    2002-01-01

    This article explores the applicability of Extreme Programming in a scientific research context. The cultural environment at a government research center differs from the customer-centric business view. The chief theoretical difficulty lies in defining the customer to developer relationship. Specifically, can Extreme Programming be utilized when the developer and customer are the same person? Eight of Extreme Programming's 12 practices are perceived to be incompatible with the existing research culture. Further, six of the nine 'environments that I know don't do well with XP' apply. A pilot project explores the use of Extreme Programming in scientific research. The applicability issues are addressed and it is concluded that Extreme Programming can function successfully in situations for which it appears to be ill-suited. A strong discipline for mentally separating the customer and developer roles is found to be key for applying Extreme Programming in a field that lacks a clear distinction between the customer and the developer.

  12. Lewis' Educational and Research Collaborative Internship Program

    Science.gov (United States)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  13. The filter/moderator arrangement-optimisation for the boron-neutron capture therapy (BNCT).

    Science.gov (United States)

    Tracz, G; Dabkowski, L; Dworak, D; Pytel, K; Woźnicka, U

    2004-01-01

    The paper presents results of the numerical modelling of the fission-converter-based epithermal neutron source designed for the boron neutron capture therapy (BNCT) facility to be located at the Polish research nuclear reactor MARIA at Swierk. The unique design of the fission converter has been proposed due to a specific geometrical surrounding of the reactor. The filter/moderator arrangement has been optimised to moderate fission neutrons to epithermal energies and to remove both fast neutrons and photons from the therapeutic beam. The selected filter/moderator set-up ensures both high epithermal neutron flux and suitably low level of beam contamination. Photons originating from the reactor core are almost eliminated what is the exceptional advantage of the proposed design. It yields one order of magnitude lower gamma radiation dose than the maximum allowed dose in such a type of therapeutic facility. The MCNP code has been used for the computations.

  14. Neutron collimator design of neutron radiography based on the BNCT facility

    Science.gov (United States)

    Yang, Xiao-Peng; Yu, Bo-Xiang; Li, Yi-Guo; Peng, Dan; Lu, Jin; Zhang, Gao-Long; Zhao, Hang; Zhang, Ai-Wu; Li, Chun-Yang; Liu, Wan-Jin; Hu, Tao; Lü, Jun-Guang

    2014-02-01

    For the research of CCD neutron radiography, a neutron collimator was designed based on the exit of thermal neutron of the Boron Neutron Capture Therapy (BNCT) reactor. Based on the Geant4 simulations, the preliminary choice of the size of the collimator was determined. The materials were selected according to the literature data. Then, a collimator was constructed and tested on site. The results of experiment and simulation show that the thermal neutron flux at the end of the neutron collimator is greater than 1.0×106 n/cm2/s, the maximum collimation ratio (L/D) is 58, the Cd-ratio(Mn) is 160 and the diameter of collimator end is 10 cm. This neutron collimator is considered to be applicable for neutron radiography.

  15. Neutron collimator design of neutron radiography based on the BNCT facility

    CERN Document Server

    Yang, XP; Li, YG; Peng, D; Lu, J; Zhang, GL; Zhao, H; Zhang, AW; Li, CY; Liu, WJ; Hu, T; Lv, JG

    2013-01-01

    For the research of CCD neutron radiography, a neutron collimator was designed based on the exit of thermal neutron of the Boron Neutron Capture Therapy (BNCT) reactor. Based on the Geant4 simulations, the preliminary choice of the size of the collimator was determined. The materials were selected according to the literature data. Then, a collimator was constructed and tested on site. The results of experiment and simulation show that the thermal neutron flux at the end of theneutron collimator is greater than 10^6 n/cm^2/s, the maximum collimation ratio (L/D) is 58, the Cd-ratio(Mn) is 160 and the diameter of collimator end is 10 cm. This neutron collimator is considered to be applicable for neutron radiography.

  16. Environmental research program: FY 1987, annual report

    Energy Technology Data Exchange (ETDEWEB)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups.

  17. Analysis of accelerator based neutron spectra for BNCT using proton recoil spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Wielopolski, L.; Ludewig, H.; Powell, J.R.; Raparia, D.; Alessi, J.G.; Lowenstein, D.I.

    1999-03-01

    Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by {sup 10}B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase 1/2 clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based neutron beam energy spectra, alternative neutron sources are being contemplated for wider implementation of this modality in a hospital environment. For example, accelerator based neutron sources offer the possibility of tailoring the neutron beams, in terms of improved depth-dose distributions, to the individual and offer, with relative ease, the capability of modifying the neutron beam energy and port size. In previous work new concepts for compact accelerator/target configuration were published. In this work, using the Van de Graaff accelerator the authors have explored different materials for filtering and reflecting neutron beams produced by irradiating a thick Li target with 1.8 to 2.5 MeV proton beams. However, since the yield and the maximum neutron energy emerging from the Li-7(p,n)Be-7 reaction increase with increase in the proton beam energy, there is a need for optimization of the proton energy versus filter and shielding requirements to obtain the desired epithermal neutron beam. The MCNP-4A computer code was used for the initial design studies that were verified with benchmark

  18. ANALYSIS OF ACCELERATOR BASED NEUTRON SPECTRA FOR BNCT USING PROTON RECOIL SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    WIELOPOLSKI,L.; LUDEWIG,H.; POWELL,J.R.; RAPARIA,D.; ALESSI,J.G.; LOWENSTEIN,D.I.

    1998-11-06

    Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by {sup 10}B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase I/II clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based neutron beam energy spectra alternative neutron sources are being contemplated for wider implementation of this modality in a hospital environment. For example, accelerator based neutron sources offer the possibility of tailoring the neutron beams, in terms of improved depth-dose distributions, to the individual and offer, with relative ease, the capability of modifying the neutron beam energy and port size. In previous work new concepts for compact accelerator/target configuration were published. In this work, using the Van de Graaff accelerator the authors have explored different materials for filtering and reflecting neutron beams produced by irradiating a thick Li target with 1.8 to 2.5 MeV proton beams. However, since the yield and the maximum neutron energy emerging from the Li-7(p,n)Be-7 reaction increase with increase in the proton beam energy, there is a need for optimization of the proton energy versus filter and shielding requirements to obtain the desired epithermal neutron beam. The MCNP-4A computer code was used for the initial design studies that were verified with benchmark

  19. Neutron field characterization in the installation for BNCT study in the IEA-R1 reactor; Caracterizacao do campo de neutrons na instalacao para estudo em BNCT no reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro Junior, Valdeci

    2008-07-01

    This work aims to characterize the mixed neutron and gamma field, in the sample irradiation position, in a research installation for Boron Neutron Capture Therapy (BNCT), in the IPEN IEA-R1 reactor. The BNCT technique has been studied as a safe and selective option in the treatment of resistant cancerigenous tumors or considered non-curable by the conventional techniques, for example, the Glioblastoma Multiform - a brain cancerigenous tumor. Neutron flux measurements were carried out: thermal, resonance and fast, as well as neutron and gamma rays doses, in the sample position, using activation foils detectors and thermoluminescent dosimeters. For the determination of the neutron spectrum and intensity, a set of different threshold activation foils and gold foils covered and uncovered with cadmium irradiated in the installation was used, analyzed by a high Pure Germanium semiconductor detector, coupled to an electronic system suitable for gamma spectrometry. The results were processed with the SAND-BP code. The doses due to gamma and neutron rays were determined using thermoluminescent dosimeters TLD 400 and TLD 700 sensitive to gamma and TLD 600, sensitive to neutrons. The TLDs were selected and used for obtaining the calibration curves - dosimeter answer versus dose - from each of the TLD three types, which were necessary to calculate the doses due to neutron and gamma, in the sample position. The radiation field, in the sample irradiation position, was characterized flux for thermal neutrons of 1.39.10{sup 8} {+-} 0,12.10{sup 8} n/cm{sup 2}s the doses due to thermal neutrons are three times higher than those due to gamma radiation and confirm the reproducibility and consistency of the experimental findings obtained. Considering these results, the neutron field and gamma radiation showed to be appropriated for research in BNCT. (author)

  20. Summer Undergraduate Research Program: Environmental studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J. [ed.

    1994-12-31

    The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. The students are offered research topics at the Medical University in the scientific areas of pharmacology and toxicology, epidemiology and risk assessment, environmental microbiology, and marine sciences. Students are also afforded the opportunity to work with faculty at the University of Charleston, SC, on projects with an environmental theme. Ten well-qualified students from colleges and universities throughout the eastern United States were accepted into the program.

  1. Dynamic infrared imaging of cutaneous melanoma and normal skin in patients treated with BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Santa Cruz, G.A. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina)], E-mail: santacr@cnea.gov.ar; Bertotti, J.; Marin, J. [Universidad Favaloro, Solis 453 (1078), Buenos Aires (Argentina); Gonzalez, S.J. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (1033), Buenos Aires (Argentina); Gossio, S. [FCEyN, Pabellon II, Ciudad Universitaria (1428), Buenos Aires (Argentina); Alvarez, D. [Fundacion Favaloro, Av. Belgrano 1746 (1093), Buenos Aires (Argentina); Roth, B.M.C.; Menendez, P. [Instituto de Oncologia Angel H. Roffo, Av. San Martin 5481 (1417), Buenos Aires (Argentina); Pereira, M.D. [Agencia Nacional de Promocion Cientifica y Tecnologica, PAV 22393 (Argentina); Albero, M.; Cubau, L.; Orellano, P. [INVAP S.E., F.P. Moreno 1089 (R8400AMU), S.C. de Bariloche, Rio Negro (Argentina); Liberman, S.J. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina)

    2009-07-15

    We recently initiated a program aimed to investigate the suitability of dynamic infrared imaging for following-up nodular melanoma patients treated with BNCT. The reason that makes infrared imaging attractive is the fact that it constitutes a functional and non-invasive imaging method, providing information on the normal and abnormal physiologic response of the nervous and vascular systems, as well as the local metabolic rate and inflammatory processes that ultimately appear as differences in the skin temperature. An infrared camera, with a focal plane array of 320x240 uncooled ferroelectric detectors is employed, which provides a video stream of the infrared emission in the 7-14 {mu}m wavelength band. A double blackbody is used as reference for absolute temperature calibration. After following a protocol for patient preparation and acclimatization, a basal study is performed. Subsequently, the anatomic region of interest is subjected to a provocation test (a cold stimulus), which induces an autonomic vasoconstriction reflex in normal structures, thus enhancing the thermal contrast due to the differences in the vasculature of the different skin regions. Radiation erythema reactions and melanoma nodules possess typically a faster temperature recovery than healthy, non-irradiated skin. However, some other non-pathological structures are also detectable by infrared imaging, (e.g. scars, vessels, arteriovenous anastomoses and injuries), thus requiring a multi-study comparison in order to discriminate the tumor signal. Besides the superficial nodules, which are readily noticeable by infrared imaging, we have detected thermal signals that are coincident with the location of non-palpable nodules, which are observable by CT and ultrasound. Diffuse regions of fast temperature recovery after a cold stimulus were observed between the third and sixth weeks post-BNCT, concurrent with the clinical manifestation of radiation erythema. The location of the erythematous visible and

  2. Theoretical Particle Physics Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Paz, Gil [Wayne State Univ., Detroit, MI (United States)

    2015-06-23

    This is the final technical report for DOE grant DE-FG02-13ER41997. It contains a brief description of accomplishments: research project that were completed during the period of the grant, research project that were started during the period of the grant, and service to the scientific community. It also lists the publications in the funded period, travel related to the grant, and information about the personal supported by the grant.

  3. The Minnesota Innovation Research Program.

    Science.gov (United States)

    1984-04-01

    P. Alderfer Yale University School of Organization and Management New Haven, Connecticut 06520 Dr. Janet L. Barnes-Farrell Department of Psychology ...a.° . . . .° . . research teams are attached to this report. Of course, these project summaries are tentative and preliminary. However, a review of...research as it progresses over the years. Local and national expert review panels will also be used each year to evaluate and redirect the innovation

  4. University Research Consortium annual review meeting program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators.

  5. Environmental research program. 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    The objective of the Environmental Research Program is to contribute to the understanding of the formation, mitigation, transport, transformation, and ecological effects of energy-related pollutants on the environment. The program is multidisciplinary and includes fundamental and applied research in chemistry, physics, biology, engineering, and ecology. The program undertakes research and development in efficient and environmentally benign combustion, pollution abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group investigates combustion, atmospheric processes, flue-gas chemistry, and ecological systems.

  6. 2016 Research Outreach Program report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Young [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kim, Yangkyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-13

    This paper is the research activity report for 4 weeks in LANL. Under the guidance of Dr. Lee, who performs nuclear physics research at LANSCE, LANL, I studied the Low Energy NZ (LENZ) setup and how to use the LENZ. First, I studied the LENZ chamber and Si detectors, and worked on detector calibrations, using the computer software, ROOT (CERN developed data analysis tool) and EXCEL (Microsoft office software). I also performed the calibration experiments that measure alpha particles emitted from a Th-229 source by using a S1-type detector (Si detector). And with Dr. Lee, we checked the result.

  7. Spectrum shaping of accelerator-based neutron beams for BNCT

    CERN Document Server

    Montagnini, B; Esposito, J; Giusti, V; Mattioda, F; Varone, R

    2002-01-01

    We describe Monte Carlo simulations of three facilities for the production of epithermal neutrons for Boron Neutron Capture Therapy (BNCT) and examine general aspects and problems of designing the spectrum-shaping assemblies to be used with these neutron sources. The first facility is based on an accelerator-driven low-power subcritical reactor, operating as a neutron amplifier. The other two facilities have no amplifier and rely entirely on their primary sources, a D-T fusion reaction device and a conventional 2.5 MeV proton accelerator with a Li target, respectively.

  8. Prostate Cancer Research Training Program

    Science.gov (United States)

    2013-05-01

    evaluate medication safety. Examples of HERCe research include recent publications on breast cancer treatments, complications of chemotherapy for...with specific interest in minimally invasive procedures, new techniques, and outcomes. Dr. Brown initiated many of the laparoscopic and robotic ... surgery as it is one of the main areas of his clinical expertise. Currently, he performs more prostate cancer surgery than any other physician in

  9. Story of a Research Program

    Directory of Open Access Journals (Sweden)

    John Sweller

    2016-02-01

    Full Text Available Lessons Learned There are several general lessons (not generic cognitive skills! that I have learned over an almost half century of research. The main one is that age-old lesson that applies to many facets of life: if you are confident of your ideas, persist.   [Download the PDF and read more . . .

  10. Prostate Cancer Research Training Program

    Science.gov (United States)

    2011-05-01

    Associate, Department of Internal Medicine (319-356-4159) http://www.int- med.uiowa.edu/Divisions/ Cardiology /Directory/Micha elSchultz.html Dr. Schultz’s...Core, DNA Core, Flow Cytometry Core, to name but a few. For research that includes laboratory animals, professional, humane veterinary care is

  11. Integrated Bioenvironmental Hazards Research Program

    Science.gov (United States)

    2004-01-01

    hepatocytes RT- PCR real time polymerase chain reaction SPRITE Summer Pipeline Research Initiative: the Tulane Experience TUHSC Tulane University Health...beta) utilizing RT- PCR ( real Time polymerase chain reaction). In addition, determine gene expression of the above-mentioned genes from preserved

  12. Breast Cancer and the Environment Research Program

    Science.gov (United States)

    The Breast Cancer and the Environment Research Program supports a multidisciplinary network of scientists, clinicians, and community partners to examine the effects of environmental exposures that may predispose a woman to breast cancer throughout her life.

  13. Environmental Research Division's Data Access Program (ERDDAP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ERDDAP (the Environmental Research Division's Data Access Program) is a data server that gives you a simple, consistent way to download subsets of scientific...

  14. Training program attracts work and health researchers

    DEFF Research Database (Denmark)

    Skakon, Janne

    2007-01-01

    Each year in Canada, the costs of disability arising from work-related causes – including workers’ compensation and health-care costs – exceed $6.7 billion. Despite the significant financial and social impacts of worker injury and illness, only a small fraction of Canadian researchers are dedicated...... to examining work disability prevention issues. An innovative program that attracts international students, the Work Disability Prevention Canadian Institutes of Health Research (CIHR) Strategic Training Program, aims to build research capacity in young researchers and to create a strong network that examines...

  15. Localizing Transnational Composition Research and Program Design

    Science.gov (United States)

    Zenger, Amy

    2016-01-01

    As an American-trained compositionist working in the Middle East, Amy Zenger questioned the ways she and others in her position conduct research and construct, revise, or administer composition programs outside of the U.S., particularly when these programs purport to adhere to American models of liberal arts education. Universities and programs…

  16. Human Research Program Integrated Research Plan. Revision A January 2009

    Science.gov (United States)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  17. FY99 Basic Research Program

    Science.gov (United States)

    2016-06-07

    commitment to 6.1 research, utilizing the expertise of faculty, reearch staff, and students in collaborative efforts. Publishing in archival journals and...and recorded. The power spectrums of these results revealed no patterns of harmonics rising above the noise floor for the cracked beams; the...imaging and chemical identification using the NFAR microscope. We expect to study biopolymers and their interactions by Fall 1999. PUBLICATIONS L.T

  18. Cleveland Clinic Rehabilitation Research Program

    Science.gov (United States)

    2015-12-01

    Maxwell-Faraday Equations. (B) Due to the nature of circular MS coils, negligible current is induced from the center of the MS coil, described as the...the patients prior to enrollment. Figure 6. iSCI patients with more functional gains from therapy had increased demyelination in the...Clinical and Translational Science Association’s Clinical Research Unit assistance has helped attenuate any safety threats. B. Publications and

  19. Prostate Cancer Research Training Program

    Science.gov (United States)

    2014-05-01

    Iowa. It is conveniently located on the northern edge of the campus and is served by the free Cambus transportation system. The Mayflower has...and museums (art, natural history, and sports). In addition, there are a large number of restaurants ranging from fast food to fine dining...of Iowa. It is conveniently located on the west campus near the research labs and is served by the free Cambus transportation system. The

  20. GAS INDUSTRY GROUNDWATER RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    James A. Sorensen; John R. Gallagher; Steven B. Hawthorne; Ted R. Aulich

    2000-10-01

    The objective of the research described in this report was to provide data and insights that will enable the natural gas industry to (1) significantly improve the assessment of subsurface glycol-related contamination at sites where it is known or suspected to have occurred and (2) make scientifically valid decisions concerning the management and/or remediation of that contamination. The described research was focused on subsurface transport and fate issues related to triethylene glycol (TEG), diethylene glycol (DEG), and ethylene glycol (EG). TEG and DEG were selected for examination because they are used in a vast majority of gas dehydration units, and EG was chosen because it is currently under regulatory scrutiny as a drinking water pollutant. Because benzene, toluene, ethylbenzene, and xylenes (collectively referred to as BTEX) compounds are often very closely associated with glycols used in dehydration processes, the research necessarily included assessing cocontaminant effects on waste mobility and biodegradation. BTEX hydrocarbons are relatively water-soluble and, because of their toxicity, are of regulatory concern. Although numerous studies have investigated the fate of BTEX, and significant evidence exists to indicate the potential biodegradability of BTEX in both aerobic and anaerobic environments (Kazumi and others, 1997; Krumholz and others, 1996; Lovely and others, 1995; Gibson and Subramanian, 1984), relatively few investigations have convincingly demonstrated in situ biodegradation of these hydrocarbons (Gieg and others, 1999), and less work has been done on investigating the fate of BTEX species in combination with miscible glycols. To achieve the research objectives, laboratory studies were conducted to (1) characterize glycol related dehydration wastes, with emphasis on identification and quantitation of coconstituent organics associated with TEG and EG wastes obtained from dehydration units located in the United States and Canada, (2) evaluate

  1. Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST).

    Science.gov (United States)

    Fujimoto, Takuya; Andoh, Tooru; Sudo, Tamotsu; Fujita, Ikuo; Fukase, Naomasa; Takeuchi, Tamotsu; Sonobe, Hiroshi; Inoue, Masayoshi; Hirose, Tkanori; Sakuma, Toshiko; Moritake, Hiroshi; Sugimoto, Tohru; Kawamoto, Teruya; Fukumori, Yoshinobu; Yamamoto, Satomi; Atagi, Shinji; Sakurai, Yoshinori; Kurosaka, Masahiro; Ono, Koji; Ichikawa, Hideki; Suzuki, Minoru

    2015-12-01

    Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.

  2. Human Research Program: 2010 Annual Report

    Science.gov (United States)

    2010-01-01

    2010 was a year of solid performance for the Human Research Program in spite of major changes in NASA's strategic direction for Human Spaceflight. Last year, the Program completed the final steps in solidifying the management foundation, and in 2010 we achieved exceptional performance from all elements of the research and technology portfolio. We transitioned from creating building blocks to full execution of the management tools for an applied research and technology program. As a team, we continue to deliver the answers and technologies that enable human exploration of space. While the Agency awaits strategic direction for human spaceflight, the Program is well positioned and critically important to helping the Agency achieve its goals.

  3. Professional Practices in Undergraduate Research Programs.

    Science.gov (United States)

    Seeling, Joni M; Choudhary, Madhusudan

    2016-05-01

    The undergraduate research experience (URE) is an important avenue within a college trajectory in which students enhance their critical thinking, learn about the scientific process, and develop the knowledge and values that will guide their future scientific and professional careers. Individual institutions, programs, departments, and faculty administer undergraduate research differently, but each should adhere to a common set of guidelines which govern the research mentoring process. Adherence to standard practices will enhance the research experience for both students and mentors. This article examines standards and guidelines for professional practices involving undergraduate research and scholarship, and will discuss lapses and limitations that students and faculty frequently confront. The growth, support, and proper management of undergraduate research programs (URPs) at primarily undergraduate institutions (PUIs) is important for maintaining a talented pool of young scientists, as students benefit greatly from direct interactions with faculty mentors that predominate at PUIs.

  4. Natural and accelerated bioremediation research program plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE`s Office of Environmental Management (EM). The program builds on OHER`s tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER`s and Office of Energy Research`s (OER`s) commitment to supporting DOE`s environmental management mission and the belief that bioremediation is an important part of the solution to DOE`s environmental problems.

  5. Core Research Program, Year 5

    Science.gov (United States)

    2002-01-01

    Dramatic losses of bone mineral density (BMD) and muscle strength are two of the best documented changes observed in humans after prolonged exposure to microgravity. Recovery of muscle upon return to a 1-G environment is well studied, however, far less is known about the rate and completeness of BMD recovery to pre-flight values. Using the mature tail-suspended adult rat model, this proposal will focus on the temporal course of recovery in tibial bone following a 28-d period of skeletal unloading. Through the study of bone density and muscle strength in the same animal, time-points during recovery from simulated microgravity will be identified when bone is at an elevated risk for fracture. These will occur due to the rapid recovery of muscle strength coupled with a slower recovery of bone, producing a significant mismatch in functional strength of these two tissues. Once the time-point of maximal mismatch is defined, various mechanical and pharmacological interventions will be tested at and around this time-point in attempt to minimize the functional difference of bone and muscle. The outcomes of this research will have high relevance for optimizing the rehabilitation of astronauts upon return to Earth, as well as upon landing on the Martian surface before assuming arduous physical tasks. Further. it will impact significantly on rehabilitation issues common to patients experiencing long periods of limb immobilization or bed rest.

  6. Base Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2008-06-30

    The main objective of the Base Research Program was to conduct both fundamental and applied research that will assist industry in developing, deploying, and commercializing efficient, nonpolluting fossil energy technologies that can compete effectively in meeting the energy requirements of the Nation. In that regard, tasks proposed under the WRI research areas were aligned with DOE objectives of secure and reliable energy; clean power generation; development of hydrogen resources; energy efficiency and development of innovative fuels from low and no-cost sources. The goal of the Base Research Program was to develop innovative technology solutions that will: (1) Increase the production of United States energy resources--coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. This report summarizes the accomplishments of the overall Base Program. This document represents a stand-alone Final Report for the entire Program. It should be noted that an interim report describing the Program achievements was prepared in 2003 covering the progress made under various tasks completed during the first five years of this Program.

  7. 77 FR 46805 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2012-08-06

    ... Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program Policy Directives... Research Program Policy Directive AGENCY: Small Business Administration. ACTION: Final policy directive... Business Innovation Research (SBIR) Policy Directive. The purpose of these amendments is to implement...

  8. Investigation of development and management of treatment planning systems for BNCT at foreign facilities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    A new computational dosimetry system for BNCT: JCDS is developed by JAERI in order to carry out BNCT with epithermal neutron beam at present. The development and management situation of computational dosimetry system, which are developed and are used in BNCT facilities in foreign countries, were investigated in order to accurately grasp functions necessary for preparation of the treatment planning and its future subjects. In present state, 'SERA', which are developed by Idaho National Engineering and Environmental Laboratory (INEEL), is used in many BNCT facilities. Followings are necessary for development and management of the treatment planning system. (1) Reliability confirmation of system performance by verification as comparison examination of calculated value with actual experimental measured value. (2) Confirmation systems such as periodic maintenance for retention of the system quality. (3) The improvement system, which always considered relative merits and demerits with other computational dosimetry system. (4) The development of integrated system with patient setting. (author)

  9. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  10. Japan sets up program for biological research

    Energy Technology Data Exchange (ETDEWEB)

    Lepkowski, W.

    1988-05-16

    Japanese officials have put final touches on plans for a global biological research program, called the Human Frontier Science Program, that they hope will launch their country into a new era of international science. Japan will establish a nongovernmental secretariat for the program and will manage it through an international governing council. Almost all the funding in the countries involved- Japan, the U.S., Canada, and the European Community countries- will be provided by Japan, at least at first. In its present design, the program consists of two thrusts- one in the neurosciences with emphasis on brain function, the other on the chemistry and molecular biology of gene expression. The program in the first year would consist of 30 to 50 direct research grants to researchers working in teams, 100 to 200 postdoctoral fellowships, and 10 to 20 workshops. Young researchers would be favored for funding. The average annual grant size would total $500,000, and postdoctoral awards would average $50,000.

  11. Overview of NRC PRA research program

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-02-01

    The NRC`s research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements.

  12. Environmental Research Program. 1994 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1995-04-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multi-disciplinary and includes fundamental research and development in efficient and environmentally-benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems.

  13. Voxel model in BNCT treatment planning: performance analysis and improvements

    Science.gov (United States)

    González, Sara J.; Carando, Daniel G.; Santa Cruz, Gustavo A.; Zamenhof, Robert G.

    2005-02-01

    In recent years, many efforts have been made to study the performance of treatment planning systems in deriving an accurate dosimetry of the complex radiation fields involved in boron neutron capture therapy (BNCT). The computational model of the patient's anatomy is one of the main factors involved in this subject. This work presents a detailed analysis of the performance of the 1 cm based voxel reconstruction approach. First, a new and improved material assignment algorithm implemented in NCTPlan treatment planning system for BNCT is described. Based on previous works, the performances of the 1 cm based voxel methods used in the MacNCTPlan and NCTPlan treatment planning systems are compared by standard simulation tests. In addition, the NCTPlan voxel model is benchmarked against in-phantom physical dosimetry of the RA-6 reactor of Argentina. This investigation shows the 1 cm resolution to be accurate enough for all reported tests, even in the extreme cases such as a parallelepiped phantom irradiated through one of its sharp edges. This accuracy can be degraded at very shallow depths in which, to improve the estimates, the anatomy images need to be positioned in a suitable way. Rules for this positioning are presented. The skin is considered one of the organs at risk in all BNCT treatments and, in the particular case of cutaneous melanoma of extremities, limits the delivered dose to the patient. Therefore, the performance of the voxel technique is deeply analysed in these shallow regions. A theoretical analysis is carried out to assess the distortion caused by homogenization and material percentage rounding processes. Then, a new strategy for the treatment of surface voxels is proposed and tested using two different irradiation problems. For a parallelepiped phantom perpendicularly irradiated with a 5 keV neutron source, the large thermal neutron fluence deviation present at shallow depths (from 54% at 0 mm depth to 5% at 4 mm depth) is reduced to 2% on average

  14. Hawaii integrated biofuels research program, phase 1

    Science.gov (United States)

    Takahashi, Patrick K.

    1989-10-01

    Hawaii provides a unique environment for production of biomass resources that can be converted into renewable energy products. The purpose of this work is to evaluate the potential of several biomass resources, including sugarcane, eucalyptus, and leucaena, particularly for utilization in thermochemical conversion processes to produce liquid or gaseous transportation fuels. This research program supports ongoing efforts of the Biofuels and Municipal Solid Waste Technology (BMWT) Program of the Department of Energy (DOE) and has goals that are consistent with BMWT. The Hawaii Natural Energy Institute (HNEI) work completed here consists of research activities that support two of the five renewable fuel cycles being pursued by DOE researchers. The results are directly applicable in the American territories throughout the Pacific Basin and the Caribbean, and also to many parts of the United States and worldwide. The Hawaii Integrated Biofuels Research Program is organized into the following six research tasks, which are presented as appendices in report form: Biomass Resource Assessment and System Modeling (Task 1); Bioenergy Tree Research (Task 2); Breeding, Culture, and Selection of Tropical Grasses for Increased Energy Potential (Task 3); Study of Eucalyptus Plantations for Energy Production in Hawaii (Task 4); Fundamental Solvolysis Research (Task 5); and Effects of Feedstock Composition on Pyrolysis Products (Task 6).

  15. TIDBIT - the INEL database of BNCT information and treatment

    Energy Technology Data Exchange (ETDEWEB)

    Mancuso, C.A.

    1995-11-01

    The INEL Database of BNCT Information and Treatment (TIDBIT) has been under development for several years. Late in 1993, a new software development team took over the project and did and assessment of the current implementation status, and determined that the user interface was unsatisfactory for the expected users and that the data structures were out of step with the current state of reality. The team evaluated several tools that would improve the user interface to make the system easier to use. Uniface turned out to be the product of choice. During 1994, TIDBIT got its name, underwent a complete change of appearance, had a major overhaul to the data structures that support the application, and system documentation was begun. A prototype of the system was demonstrated in September 1994.

  16. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  17. Mendelian Genetics: Paradigm, Conjecture, or Research Program.

    Science.gov (United States)

    Oldham, V.; Brouwer, W.

    1984-01-01

    Applies Kuhn's model of the structure of scientific revolutions, Popper's hypothetic-deductive model of science, and Lakatos' methodology of competing research programs to a historical biological episode. Suggests using Kuhn's model (emphasizing the nonrational basis of science) and Popper's model (emphasizing the rational basis of science) in…

  18. Occupational medicine programs for animal research facilities.

    Science.gov (United States)

    Wald, Peter H; Stave, Gregg M

    2003-01-01

    Occupational medicine is a key component of a comprehensive occupational health and safety program in support of laboratory animal research and production facilities. The mission of the department is to maximize employee health and productivity utilizing a population health management approach, which includes measurement and analysis of health benefits utilization. The department works in close cooperation with other institutional health and safety professionals to identify potential risks from exposure to physical, chemical, and biological hazards in the workplace. As soon as exposures are identified, the department is responsible for formulating and providing appropriate medical surveillance programs. Occupational medicine is also responsible for targeted delivery of preventive and wellness services; management of injury, disease, and disability; maintenance of medical information; and other clinic services required by the institution. Recommendations are provided for the organization and content of occupational medicine programs for animal research facilities.

  19. A research program in empirical computer science

    Science.gov (United States)

    Knight, J. C.

    1991-01-01

    During the grant reporting period our primary activities have been to begin preparation for the establishment of a research program in experimental computer science. The focus of research in this program will be safety-critical systems. Many questions that arise in the effort to improve software dependability can only be addressed empirically. For example, there is no way to predict the performance of the various proposed approaches to building fault-tolerant software. Performance models, though valuable, are parameterized and cannot be used to make quantitative predictions without experimental determination of underlying distributions. In the past, experimentation has been able to shed some light on the practical benefits and limitations of software fault tolerance. It is common, also, for experimentation to reveal new questions or new aspects of problems that were previously unknown. A good example is the Consistent Comparison Problem that was revealed by experimentation and subsequently studied in depth. The result was a clear understanding of a previously unknown problem with software fault tolerance. The purpose of a research program in empirical computer science is to perform controlled experiments in the area of real-time, embedded control systems. The goal of the various experiments will be to determine better approaches to the construction of the software for computing systems that have to be relied upon. As such it will validate research concepts from other sources, provide new research results, and facilitate the transition of research results from concepts to practical procedures that can be applied with low risk to NASA flight projects. The target of experimentation will be the production software development activities undertaken by any organization prepared to contribute to the research program. Experimental goals, procedures, data analysis and result reporting will be performed for the most part by the University of Virginia.

  20. Extending the JOVE Program through undergraduate research

    Science.gov (United States)

    Lebo, George R.

    1996-01-01

    The JOVE program was initiated in 1988 to develop NASA-related research capabilities in colleges and universities which had had little or no previous experience with NASA. Any institution which was not currently funded at more than $100 K annually by NASA was eligible. In an open competition six universities were selected for participation in the first year. NASA supplied funds, access to its facilities and data, collaboration with its researchers and a hookup to the internet. In return the university was expected to match NASA's investment by giving its participating faculty members time off of their teaching schedules to perform research during the school year, by waiving it overhead charge and by putting up real funds to match those supplied by NASA. Each school was eligible for three years after which they were expected to seek funds from other sources. Over the span of the program more than 100 colleges and universities have participated. Fifteen have finished their eligiblity. Since one of the strong components of the program was the direct involvement of undergraduate students in active research, it was decided to develop a follow-on program which would provide stipends to undergraduate students at the institutions who had used up their JOVE eligiblity. NASA's desire to transfer its technologies to the private sector now permeates all of its programs. Therefore a Partnering Venture (PAVE) program is now being discussed in which JOVE-like rules will be applied to small companies which do not now do much business with NASA. The JOVE, PAVE, and other summer activities of the author are told here.

  1. Geothermal Reservoir Technology Research Program: Abstracts of selected research projects

    Energy Technology Data Exchange (ETDEWEB)

    Reed, M.J. (ed.)

    1993-03-01

    Research projects are described in the following areas: geothermal exploration, mapping reservoir properties and reservoir monitoring, and well testing, simulation, and predicting reservoir performance. The objectives, technical approach, and project status of each project are presented. The background, research results, and future plans for each project are discussed. The names, addresses, and telephone and telefax numbers are given for the DOE program manager and the principal investigators. (MHR)

  2. Federal Geothermal Research Program Update, FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Joel Lawrence

    2001-08-01

    The Department of Energy's Geothermal Program serves two broad purposes: 1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and 2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  3. DOE (Department of Energy) Epidemiologic Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal.

  4. Human Research Program Integrated Research Plan. Revision C

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  5. Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model.

    Science.gov (United States)

    Garabalino, Marcela A; Heber, Elisa M; Monti Hughes, Andrea; González, Sara J; Molinari, Ana J; Pozzi, Emiliano C C; Nievas, Susana; Itoiz, Maria E; Aromando, Romina F; Nigg, David W; Bauer, William; Trivillin, Verónica A; Schwint, Amanda E

    2013-08-01

    Boron neutron capture therapy (BNCT) is based on selective accumulation of ¹⁰B carriers in tumor followed by neutron irradiation. We previously proved the therapeutic success of BNCT mediated by the boron compounds boronophenylalanine and sodium decahydrodecaborate (GB-10) in the hamster cheek pouch oral cancer model. Based on the clinical relevance of the boron carrier sodium borocaptate (BSH) and the knowledge that the most effective way to optimize BNCT is to improve tumor boron targeting, the specific aim of this study was to perform biodistribution studies of BSH in the hamster cheek pouch oral cancer model and evaluate the feasibility of BNCT mediated by BSH at nuclear reactor RA-3. The general aim of these studies is to contribute to the knowledge of BNCT radiobiology and optimize BNCT for head and neck cancer. Sodium borocaptate (50 mg ¹⁰B/kg) was administered to tumor-bearing hamsters. Groups of 3-5 animals were killed humanely at nine time-points, 3-12 h post-administration. Samples of blood, tumor, precancerous pouch tissue, normal pouch tissue and other clinically relevant normal tissues were processed for boron measurement by optic emission spectroscopy. Tumor boron concentration peaked to therapeutically useful boron concentration values of 24-35 ppm. The boron concentration ratio tumor/normal pouch tissue ranged from 1.1 to 1.8. Pharmacokinetic curves showed that the optimum interval between BSH administration and neutron irradiation was 7-11 h. It is concluded that BNCT mediated by BSH at nuclear reactor RA-3 would be feasible.

  6. The National Geothermal Energy Research Program

    Science.gov (United States)

    Green, R. J.

    1974-01-01

    The continuous demand for energy and the concern for shortages of conventional energy resources have spurred the nation to consider alternate energy resources, such as geothermal. Although significant growth in the one natural steam field located in the United States has occurred, a major effort is now needed if geothermal energy, in its several forms, is to contribute to the nation's energy supplies. From the early informal efforts of an Interagency Panel for Geothermal Energy Research, a 5-year Federal program has evolved whose objective is the rapid development of a commercial industry for the utilization of geothermal resources for electric power production and other products. The Federal program seeks to evaluate the realistic potential of geothermal energy, to support the necessary research and technology needed to demonstrate the economic and environmental feasibility of the several types of geothermal resources, and to address the legal and institutional problems concerned in the stimulation and regulation of this new industry.

  7. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  8. Sandia combustion research program: Annual report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, R.E.; Sanders, B.R.; Ivanetich, C.A. (eds.)

    1988-01-01

    More than a decade ago, in response to a national energy crisis, Sandia proposed to the US Department of Energy a new, ambitious program in combustion research. Our strategy was to apply the rapidly increasing capabilities in lasers and computers to combustion science and technology. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''User Facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative--involving US universities, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions of several research projects which have been stimulated by Working Groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship Program has been instrumental in the success of some of the joint efforts. The remainder of this report presents research results of calendar year 1987, separated thematically into nine categories. Refereed journal articles appearing in print during 1987, along with selected other publications, are included at the end of Section 10. In addition to our ''traditional'' research--chemistry, reacting flow, diagnostics, engine combustion, and coal combustion--you will note continued progress in somewhat recent themes: pulse combustion, high temperature materials, and energetic materials, for example. Moreover, we have just started a small, new effort to understand combustion-related issues in the management of toxic and hazardous materials.

  9. Collaborative Research Program on Seafood Toxins

    Science.gov (United States)

    1988-08-14

    Crystallographic Structures of Saxitoxins Cl and C2 Appendix C: Collaborative Research Program an Seafcod Toxins Progress Report on Ciguatera and Related...radioimmunoassay for PSP were also evalumted. The Hokama stick test for ciguatera toxin was also evaluated. 4. initiate Studies on the Accumulation...tco•d which caie a form of b-mnn poisoning referred to as ciguatera . The respcnsible toxins originate from ll1ular rine algae of the division

  10. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  11. ASRL core research program 2010 - 2011

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-01-15

    This article summarized the core research program of Alberta Sulphur Research Ltd. The high-priority projects are improved liquid sulfur degassing technologies, improved tail gas treatment processes, oxygen consumption in amine systems, formation of hydrogen sulphide (H{sub 2}S) in shale gas reservoirs and during the steam assisted gravity drainage (SAGD) recovery of heavy oil and bitumen, designer hydrocarbon sulfur solvents for sour gas production, determination of the kinetics of H{sub 2}S oxidation in compression systems, H{sub 2}S and sulphur dioxide (SO{sub 2}) solubility in liquid sulfur updating and checking FTIR calibrations, low tonnage sulfur recovery, the effect of BTX on reduction catalysts used in Claus tail gas processing, measurement of acid gas properties at high pressure, catalytic tail gas incineration, and sulfur dust properties. The projects identified as important areas of research are acid gas injection water holding capacity for acid gas mixtures; rate of decomposition of polymeric sulfur; ammonium salt plugging in the Claus Converter Train; re-examination of catalytic partial oxidation for sulfur recovery from low H{sub 2}S content hydrocarbon contaminated acid gas; primary upgrading of oil sands bitumen; prediction of sulfur deposition in sour gas reservoirs; and new extended uses of elemental sulfur. There are two fundamental research programs, which include ongoing research and partial external funding: production of C{sub 3} - C{sub 6} olefins, high octane alkylate, and valuable petrochemicals and computational modeling of catalytic systems. The commercial and specific objectives of each project were described. Two special projects, which aim to take Alberta Sulphur Research Ltd. (ASRL) core research to the commercial demonstration phase, involve injection of SO{sub 2} into disposal reservoirs and above-ground sulfur storage. 1 tab., 22 figs.

  12. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  13. Energy Efficient Industrialized Housing Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    Six area reported progress in the Energy Efficient Industrialized Housing Research Program during FY 1991. As part of Industry Guidance, meetings were held with steering and technical committees in computers, housing design and manufacturing. This task area enables the program to benefit from the expertise of industry representatives and communicate research results directly to them. As part of the Design Process performance specifications were being developed for the future housing system designed last year. These house designs coordinate and optimize predicted and desirable advances in computerized design processes, materials, components, and manufacturing automation to achieve energy efficiency at reduced first cost. Energy design software were being developed for CAD systems, stressed skin insulating core panel manufacturers; and a prototype energy sales tool. A prototype design was to be developed to integrate one or more subsystems with the building skin. As part of the Manufacturing Process we are developing a manufacturing process simulation and data base to help current and new entrants to the industrialized housing industry in assessing the impact of implementing new manufacturing techniques. For Evaluation we are developing testing plans for six units of housing on the UO campus and the stressed skin insulating core house to be constructed in Oregon. The DOW Chemical test structure will be retrofitted with a tile roof and retested to compare to the dome and conventional construction structures. Calibration of the wind tunnel will be completed so that laboratory tests can be conducted to simulate the ventilation cooling efficiency of houses in design. Research utilization and program management were either aspects of this program.

  14. 7 CFR 3406.17 - Program application materials-research.

    Science.gov (United States)

    2010-01-01

    ... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research... 7 Agriculture 15 2010-01-01 2010-01-01 false Program application materials-research....

  15. Ocean Margins Programs, Phase I research summaries

    Energy Technology Data Exchange (ETDEWEB)

    Verity, P. [ed.

    1994-08-01

    During FY 1992, the DOE restructured its regional coastal-ocean programs into a new Ocean Margins Program (OMP), to: Quantify the ecological and biogeochemical processes and mechanisms that affect the cycling, flux, and storage of carbon and other biogenic elements at the land/ocean interface; Define ocean-margin sources and sinks in global biogeochemical cycles, and; Determine whether continental shelves are quantitatively significant in removing carbon dioxide from the atmosphere and isolating it via burial in sediments or export to the interior ocean. Currently, the DOE Ocean Margins Program supports more than 70 principal and co-principal investigators, spanning more than 30 academic institutions. Research funded by the OMP amounted to about $6.9M in FY 1994. This document is a collection of abstracts summarizing the component projects of Phase I of the OMP. This phase included both research and technology development, and comprised projects of both two and three years duration. The attached abstracts describe the goals, methods, measurement scales, strengths and limitations, and status of each project, and level of support. Keywords are provided to index the various projects. The names, addresses, affiliations, and major areas of expertise of the investigators are provided in appendices.

  16. Dryden Flight Research Center Chemical Pharmacy Program

    Science.gov (United States)

    Davis, Bette

    1997-01-01

    The Dryden Flight Research Center (DFRC) Chemical Pharmacy "Crib" is a chemical sharing system which loans chemicals to users, rather than issuing them or having each individual organization or group purchasing the chemicals. This cooperative system of sharing chemicals eliminates multiple ownership of the same chemicals and also eliminates stockpiles. Chemical management duties are eliminated for each of the participating organizations. The chemical storage issues, hazards and responsibilities are eliminated. The system also ensures safe storage of chemicals and proper disposal practices. The purpose of this program is to reduce the total releases and transfers of toxic chemicals. The initial cost of the program to DFRC was $585,000. A savings of $69,000 per year has been estimated for the Center. This savings includes the reduced costs in purchasing, disposal and chemical inventory/storage responsibilities. DFRC has chemicals stored in 47 buildings and at 289 locations. When the program is fully implemented throughout the Center, there will be three chemical locations at this facility. The benefits of this program are the elimination of chemical management duties; elimination of the hazard associated with chemical storage; elimination of stockpiles; assurance of safe storage; assurance of proper disposal practices; assurance of a safer workplace; and more accurate emissions reports.

  17. 76 FR 11765 - Education Research and Special Education Research Grant Programs; Institute of Education Sciences...

    Science.gov (United States)

    2011-03-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Education Research and Special Education Research Grant Programs; Institute of Education Sciences; Overview Information; Education Research and Special Education Research Grant Programs; Notice Inviting...

  18. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  19. Environmental research program. 1995 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1996-06-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multidisciplinary and includes fundamental research and development in efficient and environmentally benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and noncriteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems. Combustion chemistry research emphasizes modeling at microscopic and macroscopic scales. At the microscopic scale, functional sensitivity analysis is used to explore the nature of the potential-to-dynamics relationships for reacting systems. Rate coefficients are estimated using quantum dynamics and path integral approaches. At the macroscopic level, combustion processes are modelled using chemical mechanisms at the appropriate level of detail dictated by the requirements of predicting particular aspects of combustion behavior. Parallel computing has facilitated the efforts to use detailed chemistry in models of turbulent reacting flow to predict minor species concentrations.

  20. Gas Hydrates Research Programs: An International Review

    Energy Technology Data Exchange (ETDEWEB)

    Jorge Gabitto; Maria Barrufet

    2009-12-09

    Gas hydrates sediments have the potential of providing a huge amount of natural gas for human use. Hydrate sediments have been found in many different regions where the required temperature and pressure conditions have been satisfied. Resource exploitation is related to the safe dissociation of the gas hydrate sediments. Basic depressurization techniques and thermal stimulation processes have been tried in pilot efforts to exploit the resource. There is a growing interest in gas hydrates all over the world due to the inevitable decline of oil and gas reserves. Many different countries are interested in this valuable resource. Unsurprisingly, developed countries with limited energy resources have taken the lead in worldwide gas hydrates research and exploration. The goal of this research project is to collect information in order to record and evaluate the relative strengths and goals of the different gas hydrates programs throughout the world. A thorough literature search about gas hydrates research activities has been conducted. The main participants in the research effort have been identified and summaries of their past and present activities reported. An evaluation section discussing present and future research activities has also been included.

  1. PISCES Program: Summary of research, 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-10-01

    This paper discusses the research of the PISCES Program. Topics discussed are: deuterium pumping by C-C composites and graphites; reduced particle recycling from grooved graphite surfaces; surface analysis of graphite tiles exposed in tokamaks; erosion behavior of redeposition layers from tokamaks (tokamakium); high temperature erosion of graphite; collaboration on TFTR probe measurements of implanted D; spectroscopic studies of carbon containing molecules; presheath profile measurements; biased limiter/divertor experiments; particle transport in the CCT tokamak edge plasma; and experimental studies of biased divertors and limiters. 26 refs., 23 figs. (LSP)

  2. Characterisation of an accelerator-based neutron source for BNCT versus beam energy

    CERN Document Server

    Agosteo, S; D'Errico, F; Nath, R; Tinti, R

    2002-01-01

    Neutron capture in sup 1 sup 0 B produces energetic alpha particles that have a high linear energy transfer in tissue. This results in higher cell killing and a higher relative biological effectiveness compared to photons. Using suitably designed boron compounds which preferentially localize in cancerous cells instead of healthy tissues, boron neutron capture therapy (BNCT) has the potential of providing a higher tumor cure rate within minimal toxicity to normal tissues. This clinical approach requires a thermal neutron source, generally a nuclear reactor, with a fluence rate sufficient to deliver tumorcidal doses within a reasonable treatment time (minutes). Thermal neutrons do not penetrate deeply in tissue, therefore BNCT is limited to lesions which are either superficial or otherwise accessible. In this work, we investigate the feasibility of an accelerator-based thermal neutron source for the BNCT of skin melanomas. The source was designed via MCNP Monte Carlo simulations of the thermalization of a fast ...

  3. Design of an epithermal column for BNCT based on D D fusion neutron facility

    Science.gov (United States)

    Durisi, E.; Zanini, A.; Manfredotti, C.; Palamara, F.; Sarotto, M.; Visca, L.; Nastasi, U.

    2007-05-01

    Boron Neutron Capture Therapy (BNCT) is currently performed on patients at nuclear reactors. At the same time the international BNCT community is engaged in the development of alternative facilities for in-hospital treatments. This paper investigates the potential of a novel high-output D-D neutron generator, developed at Lawrence Berkeley National Laboratory (CA, USA), for BNCT. The simulation code MCNP-4C is used to realize an accurate study of the epithermal column in view of the treatment of deep tumours. Different materials and Beam Shaping Assemblies (BSA) are investigated and an optimized configuration is proposed. The neutron beam quality is defined by the standard free beam parameters, calculated averaging over the collimator aperture. The results are discussed and compared with the performances of other facilities.

  4. BNCT of 3 cases of spontaneous head and neck cancer in feline patients

    Energy Technology Data Exchange (ETDEWEB)

    Rao, M.; Trivillin, V.A.; Heber, E.M.; Angeles Cantarelli, Maria de los; Itoiz, M.E.; Nigg, D.W.; Rebagliati, R.J.; Batistoni, Daniel; Schwint, A.E. E-mail: schwint@cnea.gov.ar

    2004-11-01

    Having demonstrated BPA-BNCT induced control of experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa with no damage to normal tissue we explored the feasibility and safety of treating spontaneous head and neck tumors, with particular focus on SCC, of terminal feline patients with low dose BPA-BNCT employing the thermal beam of the RA-1 Reactor within a preclinical context. The biodistribution studies showed that, in all three cases evaluated, BPA delivered absolute boron values to tumor in the range that proved therapeutically useful in the experimental model of SCC. BPA-BNCT studies showed no radiotoxic effects, partial tumor control in terms of impaired growth and partial necrosis, an improvement in clinical condition and prolonged survival beyond the terminal condition of the feline patients at the time of recruitment.

  5. The Boron Neutron Capture Therapy (BNCT) Project at the TRIGA Reactor in Mainz, Germany

    Energy Technology Data Exchange (ETDEWEB)

    Hampel, G.; Grunewald, C.; Schutz, C.; Schmitz, T.; Kratz, J.V. [Nuclear Chemistry, University of Mainz, D-55099 Mainz (Germany); Brochhausen, C.; Kirkpatrick, J. [Department of Pathology, University of Mainz, D-55099 Mainz (Germany); Bortulussi, S.; Altieri, S. [Department of Nuclear and Theoretical Physics University of Pavia, Pavia (Italy); National Institute of Nuclear Physics (INFN) Pavia Section, Pavia (Italy); Kudejova, P. [Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universitaet Muenchen, D-85748 Garching (Germany); Appelman, K.; Moss, R. [Joint Research Centre (JRC) of the European Commission, NL-1755 ZG Petten (Netherlands); Bassler, N. [University of Aarhus, Norde Ringade, DK-8000, Aarhus C (Denmark); Blaickner, M.; Ziegner, M. [Molecular Medicine, Health and Environment Department, AIT Austrian Institute of Technology GmbH (Austria); Sharpe, P.; Palmans, H. [National Physical Laboratory, Teddington TW11 0LW, Middlesex (United Kingdom); Otto, G. [Department of Hepatobiliary, Pancreatic and Transplantation Surgery, University of Mainz, D-55099 Mainz (Germany)

    2011-07-01

    The thermal column of the TRIGA reactor in Mainz is being used very effectively for medical and biological applications. The BNCT (boron neutron capture therapy) project at the University of Mainz is focussed on the treatment of liver tumours, similar to the work performed in Pavia (Italy) a few years ago, where patients with liver metastases were treated by combining BNCT with auto-transplantation of the organ. Here, in Mainz, a preclinical trial has been started on patients suffering from liver metastases of colorectal carcinoma. In vitro experiments and the first animal tests have also been initiated to investigate radiobiological effects of radiation generated during BNCT. For both experiments and the treatment, a reliable dosimetry system is necessary. From work elsewhere, the use of alanine detectors appears to be an appropriate dosimetry technique. (author)

  6. Geothermal Research Program of the US Geological Survey

    Energy Technology Data Exchange (ETDEWEB)

    Duffield, W.A.; Guffanti, M.

    1981-01-01

    The beginning of the Geothermal Research Program, its organization, objectives, fiscal history, accomplishments, and present emphasis. The projects of the Geothermal Research Program are presented along with a list of references.

  7. National Research Council Research Associateships Program with Methane Hydrates Fellowships Program/National Energy Technology Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Basques, Eric O. [National Academy of Sciences, Washington, DC (United States)

    2014-03-20

    This report summarizes work carried out over the period from July 5, 2005-January 31, 2014. The work was carried out by the National Research Council Research Associateships Program of the National Academies, under the US Department of Energy's National Energy Technology Laboratory (NETL) program. This Technical Report consists of a description of activity from 2005 through 2014, broken out within yearly timeframes, for NRC/NETL Associateships researchers at NETL laboratories which includes individual tenure reports from Associates over this time period. The report also includes individual tenure reports from associates over this time period. The report also includes descriptions of program promotion efforts, a breakdown of the review competitions, awards offered, and Associate's activities during their tenure.

  8. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  9. Might iodomethyl-{alpha}-tyrosine be a surrogate for BPA in BNCT?

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.

    1996-12-31

    A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with {sup 10}B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that {sup 10}B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing {sup 18}F-fluoroboronophenylaianine [FBPA] as a positron {sup 18}F (T{sub 1/2} = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of {sup 123}I alpha methyltyrosine as a surrogate for BPA in BNCT.

  10. 30 CFR 402.6 - Water-Resources Research Program.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources Programs §...

  11. Research Experiences in Community College Science Programs

    Science.gov (United States)

    Beauregard, A.

    2011-12-01

    research with my community college students by partnering with a research oceanographer. Through this partnership, students have had access to an active oceanographic researcher through classroom visits, use of data in curriculum, and research/cruise progress updates. With very little research activity currently going on at the community college, this "window" into scientific research is invaluable. Another important aspect of this project is the development of a summer internship program that has allowed four community college students to work directly with an oceanographer in her lab for ten weeks. This connection of community college students with world-class scientists in the field promotes better understanding of research and potentially may encourage more students to major in the sciences. In either approach, the interaction with scientists at different stages of their careers, from undergraduate and graduate students at universities to post docs and research scientists, also provides community college students with the opportunity to gain insight into possible career pathways. For both majors and non-majors, a key outcome of such experiences will be gaining experience in using inquiry and reasoning through the scientific method and becoming comfortable with data and technology.

  12. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  13. A Survey of Campus Coordinators of Undergraduate Research Programs

    Science.gov (United States)

    Hensley, Merinda Kaye; Shreeves, Sarah L.; Davis-Kahl, Stephanie

    2015-01-01

    Interest in supporting undergraduate research programs continues to grow within academic librarianship. This article presents how undergraduate research program coordinators perceive and value library support of their programs. Undergraduate research coordinators from a variety of institutions were surveyed on which elements of libraries and…

  14. 75 FR 15756 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2010-03-30

    ... ADMINISTRATION RIN 3244-AF61 Small Business Innovation Research Program Policy Directive AGENCY: U.S. Small... announces a final amendment to the Small Business Innovation Research (SBIR) Program Policy Directive (PD... the Policy Directive; Small Business Innovation Research Program To: The Directors, Small...

  15. DOE-EERC jointly sponsored research program

    Energy Technology Data Exchange (ETDEWEB)

    Hendrikson, J.G.; Sondreal, E.A.

    1999-09-01

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC21-93MC30098 funded through the Office of Fossil Energy and administered at the Federal Energy Technology Center (FETC) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy and Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying efficient, nonpolluting energy technologies that can compete effectively in meeting market demands for clean fuels, chemical feedstocks, and electricity in the 21st century. The objective of the JSRP was to advance the deployment of advanced technologies for improving energy efficiency and environmental performance through jointly sponsored research on topics that would not be adequately addressed by the private sector alone. Examples of such topics include the barriers to hot-gas cleaning impeding the deployment of high-efficiency power systems and the search for practical means for sequestering CO{sub 2} generated by fossil fuel combustion. The selection of particular research projects was guided by a combination of DOE priorities and market needs, as provided by the requirement for joint venture funding approved both by DOE and the private sector sponsor. The research addressed many different energy resource and related environmental problems, with emphasis directed toward the EERC's historic lead mission in low-rank coals (LRCs), which represent approximately half of the U.S. coal resources in the conterminous states, much larger potential resources in Alaska, and a major part of the energy base in the former U.S.S.R., East Central Europe, and the Pacific Rim. The Base and JSRP agreements were tailored to the growing awareness of critical environmental issues, including water supply and quality, air toxics (e.g., mercury), fine respirable particulate matter (PM{sub 2.5}), and the goal of zero net CO{sub 2} emissions.

  16. FY 1995 research highlights: PNL accomplishments in OER programs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  17. Solar Research Programs at IRSOL, Switzerland

    CERN Document Server

    Ramelli, R; Stenflo, J O; Jetzer, P

    2009-01-01

    The Zurich IMaging POLarimeter (ZIMPOL) developed at ETH Zurich and installed permanently at the Gregory Coude Telescope at Istituto Ricerche Solari Locarno (IRSOL) allows a polarimetric precision down to 10^-5 to be reached. This makes it possible to perform several accurate spectro-polarimetric measurements of scattering polarization and to investigate solar magnetic fields through the signatures of the Hanle and Zeeman effects. The research programs are currently being extended to monochromatic imaging of the Stokes vector with a recently installed Fabry-Perot rapidly tunable filter system with a narrow pass band of about 30mA. The spatial resolution is being improved by the installation of an Adaptive Optics system.

  18. Overview of NASA's Microgravity Materials Research Program

    Science.gov (United States)

    Downey, James Patton; Grugel, Richard

    2012-01-01

    The NASA microgravity materials program is dedicated to conducting microgravity experiments and related modeling efforts that will help us understand the processes associated with the formation of materials. This knowledge will help improve ground based industrial production of such materials. The currently funded investigations include research on the distribution of dopants and formation of defects in semiconductors, transitions between columnar and dendritic grain morphology, coarsening of phase boundaries, competition between thermally and kinetically favored phases, and the formation of glassy vs. crystalline material. NASA microgravity materials science investigators are selected for funding either through a proposal in response to a NASA Research Announcement or by participation in a team proposing to a foreign agency research announcement. In the latter case, a US investigator participating in a successful proposal to a foreign agency can then apply to NASA for funding of an unsolicited proposal. The program relies on cooperation with other aerospace partners from around the world. The ISS facilities used for these investigations are provided primarily by partnering with foreign agencies and in most cases the US investigators are working as a part of a larger team studying a specific area of materials science. The following facilities are to be utilized for the initial investigations. The ESA provided Low Gradient Facility and the Solidification and Quench Inserts to the Materials Research Rack/Materials Science Laboratory are to be used primarily for creating bulk samples that are directionally solidified or quenched from a high temperature melt. The CNES provided DECLIC facility is used to observe morphological development in transparent materials. The ESA provided Electro-Magnetic Levitator (EML) is designed to levitate, melt and then cool samples in order to study nucleation behavior. The facility provides conditions in which nucleation of the solid is

  19. Neutron-photon mixed field dosimetry by TLD-700 glow curve analysis and its implementation in dose monitoring for Boron Neutron Capture Therapy (BNCT) treatments

    Energy Technology Data Exchange (ETDEWEB)

    Boggio, E. F.; Longhino, J. M. [Centro Atomico Bariloche, Departamento de Fisica de Reactores y Radiaciones / CNEA, Av. E. Bustillo Km 9.5, R8402AGP San Carlos de Bariloche (Argentina); Andres, P. A., E-mail: efboggio@cab.cnea.gov.ar [Centro Atomico Bariloche, Division Proteccion Radiologica / CNEA, Av. E. Bustillo Km 9.5, R8402AGP San Carlos de Bariloche (Argentina)

    2015-10-15

    BNCT is a cancerous cells selective, non-conventional radiotherapy modality to treat malignant tumors such as glioblastoma, melanoma and recurrent head and neck cancer. It consists of a two-step procedure: first, the patient is injected with a tumor localizing drug containing a non-radioactive isotope (Boron-10) with high slow neutron capture cross-section. In a second step, the patient is irradiated with neutrons, which are absorbed by the Boron-10 agent with the subsequently nuclear reaction B- 10(n,a)Li-7, thereby resulting in dose at cellular level due to the high-Let particles. The neutron fields suitable for BNCT are characterized by high neutron fluxes and low gamma dose. Determination of each component is not an easy task, especially when the volume of measurement is quite small or inaccessible for a miniature ionization chamber, for example. A method of measuring the photon and slow neutron dose(mainly by N-14 and B-10) from the glow curve (GC) analysis of a single {sup 7}LiF thermoluminescence detector is evaluated. This method was suggested by the group headed by Dr. Grazia Gambarini. The dosemeters used were TLD-600 ({sup 6}LiF:Mg,Ti with 95.6% {sup 6}Li) and TLD-700 ({sup 7}LiF:Mg,Ti with 99.9% {sup 7}LiF) from Harshaw. Photon dose measurement using the GC analysis method with TLD-700 in mixed fields requires the relation of the two main peaks of a TLD-600 GC shape obtained from an exposition to the same neutron field, and a photon calibrated GC with TLD-700. The requirements for slow neutron dose measurements are similar. In order to properly apply the GC analysis method at the Ra-6 Research Reactor BNCT facility, measurements were carried out in a standard water phantom, fully characterized on the BNCT beam by conventional techniques (activation detectors and paired ionization chambers technique). Next, the method was implemented in whole body dose monitoring of a patient undergoing a BNCT treatment, using a Bo MAb (Bottle Manikin Absorption) phantom

  20. Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: combined administration of BSH and BPA.

    Science.gov (United States)

    Garabalino, Marcela A; Heber, Elisa M; Monti Hughes, Andrea; Pozzi, Emiliano C C; Molinari, Ana J; Nigg, David W; Bauer, William; Trivillin, Verónica A; Schwint, Amanda E

    2014-06-01

    Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

  1. Boron neutron capture therapy (BNCT): implications of neutron beam and boron compound characteristics.

    Science.gov (United States)

    Wheeler, F J; Nigg, D W; Capala, J; Watkins, P R; Vroegindeweij, C; Auterinen, I; Seppälä, T; Bleuel, D

    1999-07-01

    The potential efficacy of boron neutron capture therapy (BNCT) for malignant glioma is a significant function of epithermal-neutron beam biophysical characteristics as well as boron compound biodistribution characteristics. Monte Carlo analyses were performed to evaluate the relative significance of these factors on theoretical tumor control using a standard model. The existing, well-characterized epithermal-neutron sources at the Brookhaven Medical Research Reactor (BMRR), the Petten High Flux Reactor (HFR), and the Finnish Research Reactor (FiR-1) were compared. Results for a realistic accelerator design by the E. O. Lawrence Berkeley National Laboratory (LBL) are also compared. Also the characteristics of the compound p-Boronophenylaline Fructose (BPA-F) and a hypothetical next-generation compound were used in a comparison of the BMRR and a hypothetical improved reactor. All components of dose induced by an external epithermal-neutron beam fall off quite rapidly with depth in tissue. Delivery of dose to greater depths is limited by the healthy-tissue tolerance and a reduction in the hydrogen-recoil and incident gamma dose allow for longer irradiation and greater dose at a depth. Dose at depth can also be increased with a beam that has higher neutron energy (without too high a recoil dose) and a more forward peaked angular distribution. Of the existing facilities, the FiR-1 beam has the better quality (lower hydrogen-recoil and incident gamma dose) and a penetrating neutron spectrum and was found to deliver a higher value of Tumor Control Probability (TCP) than other existing beams at shallow depth. The greater forwardness and penetration of the HFR the FiR-1 at greater depths. The hypothetical reactor and accelerator beams outperform at both shallow and greater depths. In all cases, the hypothetical compound provides a significant improvement in efficacy but it is shown that the full benefit of improved compound is not realized until the neutron beam is fully

  2. Multiphysics Analysis of the 2.5 MeV BNCT RFQ Accelerator

    CERN Document Server

    Xiaowen, Zhu; Kun, Zhu

    2016-01-01

    Boron Neutron Capture Therapy (BNCT), is an advanced cancer therapy that destroys the cancer tumors using the well-known Li(p,n)Be . Because of the highly selectively reaction between a boron and a neutron, BNCT is effective for rapidly spreading cancer, invasive carcinoma, such as head and neck cancer, melanoma, malignant brain tumors and so on. The PKU RFQ group proposes an RFQ based neutron source for BNCT application. The 162.5 MHz four-vane RFQ will accelerate 20-mA H+ from 35.0 keV to 2.50 MeV in CW mode, and delivers a neutron yield of 1.73*10^13 n/sec/cm^2. The thermal management will become the most important issues. The detailed multiphysics analysis of the BNCT RFQ will be studied, and the RFQ frequency shift during nominal operating condition is also predicted. The multiphysics analysis is performed by using the CST Multiphysics Model and verified with ANSYS Multiphysics.

  3. The Boron Neutron Capture Therapy (BNCT) Project at the TRIGA Reactor in Mainz, Germany

    DEFF Research Database (Denmark)

    Hampel, G.; Grunewald, C.; Schütz, C.

    2011-01-01

    The thermal column of the TRIGA reactor in Mainz is being used very effectively for medical and biological applications. The BNCT (boron neutron capture therapy) project at the University of Mainz is focussed on the treatment of liver tumours, similar to the work performed at Pavia (Italy) a few...

  4. Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)

    Energy Technology Data Exchange (ETDEWEB)

    Kettenbach, Kathrin; Schieferstein, Hanno; Grunewald, Catrin; Hampel, Gabriele; Schuetz, Christian L. [Mainz Univ. (Germany). Inst. of Nuclear Chemistry; Iffland, Dorothee; Bings, Nicolas H. [Mainz Univ. (Germany). Inst. of Inorganic Chemistry and Analytical Chemistry; Reffert, Laura M. [Hannover Medical School (Germany). Radiopharmaceutical Chemistry; Ross, Tobias L. [Mainz Univ. (Germany). Inst. of Nuclear Chemistry; Hannover Medical School (Germany). Radiopharmaceutical Chemistry

    2015-07-01

    Boron neutron capture therapy (BNCT) employs {sup 10}B-pharmaceuticals administered for the treatment of malignancies, and subsequently irradiated with thermal neutrons. So far, clinical established pharmaceuticals like boron phenylalanine (BPA) or sodium boron mercaptate (BSH) use imperfect (BPA) or passive (BSH) targeting for accumulation at target sites. Due to the need of a selective transportation of boron drugs into cancer cells and sparing healthy tissues, we combined the BNCT approach with the specific and effective folate receptor (FR) targeting concept. The FR is overexpressed on many human carcinomas and provides a selective and specific target for molecular imaging as well as for tumor therapy. We synthesized and characterized a carborane-folate as well as a BSH-folate to study their in vitro characteristics and their potential as new boron-carriers for BNCT. Uptake studies were carried out using human KB cells showing a significant increase of the boron content in cells and demonstrating the successful combination of active FR-targeting and BNCT.

  5. First tomographic image of neutron capture rate in a BNCT facility

    Energy Technology Data Exchange (ETDEWEB)

    Minsky, D.M., E-mail: minsky@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina)] [Conicet, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina)] [Conicet, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Green, S.; Wojnecki, C. [School of Physics and Astronomy, University of Birmingham, B15 2 TT (United Kingdom)] [Department of Medical Physics, University Hospital Birmingham, Birmingham B15 2TH (United Kingdom); Ghani, Z. [Department of Medical Physics, University Hospital Birmingham, Birmingham B15 2TH (United Kingdom)

    2011-12-15

    This work discusses the development of online dosimetry of the boron dose via Single Photon Emission Computed Tomography (SPECT) during a BNCT treatment irradiation. Such a system will allow the online computation of boron dose maps without the large current uncertainties in the assessment of the boron concentration in different tissues. The first tomographic boron dose image with a SPECT prototype is shown.

  6. BNCT dosimetry performed with a mini twin tissue-equivalent proportional counters (TEPC).

    Science.gov (United States)

    Moro, D; Colautti, P; Lollo, M; Esposito, J; Conte, V; De Nardo, L; Ferretti, A; Ceballos, C

    2009-07-01

    The BNCT radiation field is complex because different beam components are mixed, each one having different relative biological effectiveness (RBE). Microdosimetry with tissue-equivalent proportional counters (TEPC) has proven to be an ideal dosimetric technique for mixed radiation fields, because it is able both to measure the absorbed dose and to assess the radiation field relative biological effectiveness with good accuracy. An ideal detector for BNCT should contain two TEPCs, one detector loaded with, while the other one without (10)B in order to record all beam components with a unique measurement. Moreover, such a detector should be of tiny size in order to be able to measure in the intense BNCT radiation fields without significant pile-up effects. TEPCs have been shown to be pretty good dosimeters for mixed radiation fields. In this paper the first mini twin TEPC counter for BNCT is presented, as well as first measurement at the new HYTHOR thermal irradiation facility at TAPIRO nuclear reactor and comparison with related Monte Carlo calculations.

  7. Research undertaken by CAS scientists with support of "973 Program"

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The National Basic Research Program (dubbed as the "973 Program") is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1 997 and is organized and implemented by the Ministry of Science and Technology.

  8. Ecological Research Division Theoretical Ecology Program. [Contains abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-01

    This report presents the goals of the Theoretical Ecology Program and abstracts of research in progress. Abstracts cover both theoretical research that began as part of the terrestrial ecology core program and new projects funded by the theoretical program begun in 1988. Projects have been clustered into four major categories: Ecosystem dynamics; landscape/scaling dynamics; population dynamics; and experiment/sample design.

  9. Bystander effect-induced mutagenicity in HPRT locus of CHO cells following BNCT neutron irradiation: Characteristics of point mutations by sequence analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kinashi, Yuko [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka (Japan)], E-mail: kinashi@rri.kyoto-u.ac.jp; Suzuki, Minoru; Masunaga, Shinichiro; Ono, Koji [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka (Japan)

    2009-07-15

    To investigate bystander mutagenic effects induced by alpha particles during boron neutron capture therapy (BNCT), we mixed cells that were electroporated with borocaptate sodium (BSH), which led to the accumulation of {sup 10}B inside the cells, with cells that did not contain the boron compound. BSH-containing cells were irradiated with {alpha} particles produced by the {sup 10}B(n,{alpha}){sup 7}Li reaction, whereas cells without boron were only affected by the {sup 1}H(n,{gamma}){sup 2}H and {sup 14}N(n,{rho}){sup 14}C reactions. The frequency of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus was examined in Chinese hamster ovary (CHO) cells irradiated with neutrons (Kyoto University Research Reactor: 5 MW). Neutron irradiation of 1:1 mixtures of cells with and without BSH resulted in a survival fraction of 0.1, and the cells that did not contain BSH made up 99.4% of the surviving cell population. Using multiplex polymerase chain reactions (PCRs), molecular structural analysis indicated that most of the mutations induced by the bystander effect were point mutations and that the frequencies of total and partial deletions induced by the bystander effect were lower than those resulting from the {alpha} particles produced by the {sup 10}B(n,{alpha}){sup 7}Li reaction or the neutron beam from the {sup 1}H(n,{gamma}){sup 2}H and {sup 14}N(n,{rho}){sup 14}C reactions. The types of point mutations induced by the BNCT bystander effect were analyzed by cloning and sequencing methods. These mutations were comprised of 65.5% base substitutions, 27.5% deletions, and 7.0% insertions. Sequence analysis of base substitutions showed that transversions and transitions occurred in 64.7% and 35.3% of cases, respectively. G:C{yields}T:A transversion induced by 8-oxo-guanine in DNA occurred in 5.9% of base substitution mutants in the BNCT bystander group. The characteristic mutations seen in this group, induced by BNCT {alpha} particles

  10. Center Independent Research & Developments: JPL IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative projects are sought in the areas of basic research, fundamental research, applied research, development and systems and other concept formulation studies....

  11. A D-D/D-T fusion reaction based neutron generator system for liver tumor BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Koivunoro, H.; Lou, T.P.; Leung, K. N.; Reijonen, J.

    2003-04-02

    Boron-neutron capture therapy (BNCT) is an experimental radiation treatment modality used for highly malignant tumor treatments. Prior to irradiation with low energetic neutrons, a 10B compound is located selectively in the tumor cells. The effect of the treatment is based on the high LET radiation released in the {sup 10}B(n,{alpha}){sup 7}Li reaction with thermal neutrons. BNCT has been used experimentally for brain tumor and melanoma treatments. Lately applications of other severe tumor type treatments have been introduced. Results have shown that liver tumors can also be treated by BNCT. At Lawrence Berkeley National Laboratory, various compact neutron generators based on D-D or D-T fusion reactions are being developed. The earlier theoretical studies of the D-D or D-T fusion reaction based neutron generators have shown that the optimal moderator and reflector configuration for brain tumor BNCT can be created. In this work, the applicability of 2.5 MeV neutrons for liver tumor BNCT application was studied. The optimal neutron energy for external liver treatments is not known. Neutron beams of different energies (1eV < E < 100 keV) were simulated and the dose distribution in the liver was calculated with the MCNP simulation code. In order to obtain the optimal neutron energy spectrum with the D-D neutrons, various moderator designs were performed using MCNP simulations. In this article the neutron spectrum and the optimized beam shaping assembly for liver tumor treatments is presented.

  12. Graduate programs in health administration: faculty academic reputation and faculty research reputation by program location and program reputation.

    Science.gov (United States)

    Nowicki, M

    1995-01-01

    This study used program location and program reputation to describe two important faculty characteristics: academic reputation and research reputation. The study involved 44 graduate programs in health administration representing four program locations: schools of public health, business, medicine/allied health, and graduate/independent. Fourteen programs were identified as ranked programs and the remaining 30 programs were identified as unranked programs. While the study identifies many differences, few are significant, thus adding credence to the argument for diversity in program location and diminishing credence in the argument for program reputation.

  13. Summer Research Program (1992). Graduate Student Research Programs Reports. Armstrong Laboratory. Volume 7

    Science.gov (United States)

    1992-12-28

    Gottlob 15 The Effects of Two Doses of Exogenous Melatonin on Temperature and Rod J. Hughes Subjective Fatigue 16 Assisting Air Force Instructional... Gottlob Department of Psychology Arizona State University Tempe, AZ 85287 Final Report for Summer Research Program Armstrong Laboratory Sponsored by: Air...TASK Lawrence R. Gottlob Department of Psychology Arizona State University In a previous study, it was found that observers could allocate attention to

  14. Situated Research Design and Methodological Choices in Formative Program Evaluation

    Science.gov (United States)

    Supovitz, Jonathan

    2013-01-01

    Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

  15. Directory of research projects, 1991. Planetary geology and geophysics program

    Science.gov (United States)

    Maxwell, Ted A. (Editor)

    1991-01-01

    Information is provided about currently funded scientific research within the Planetary Geology and Geophysics Program. The directory consists of the proposal summary sheet from each proposal funded by the program during fiscal year 1991. Information is provided on the research topic, principal investigator, institution, summary of research objectives, past accomplishments, and proposed investigators.

  16. Directory of research projects: Planetary geology and geophysics program

    Science.gov (United States)

    Holt, Henry (Editor)

    1992-01-01

    Information about currently funded scientific research within the Planetary Geology and Geophysics Program is provided. The directory consists of the proposal summary sheet from each proposal funded under the program during Fiscal Year 1992. The sheets provide information about the research project, including title, principal investigator, institution, summary of research objectives, past accomplishments, and proposed new investigations.

  17. DECONTAMINATION SYSTEMS AND INFORMATION RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Echol E. Cook, Ph.D., PE.

    1998-11-01

    During the five plus years this Cooperative Agreement existed, more than 45 different projects were funded. Most projects were funded for a one year period but there were some, deemed of such quality and importance, funded for multiple years. Approximately 22 external agencies, businesses, and other entities have cooperated with or been funded through the WVU Cooperative Agreement over the five plus years. These external entities received 33% of the funding by this Agreement. The scope of this Agreement encompassed all forms of hazardous waste remediation including radioactive, organic, and inorganic contaminants. All matrices were of interest; generally soil, water, and contaminated structures. Economic, health, and regulatory aspects of technologies were also within the scope of the agreement. The highest priority was given to small businesses funded by the Federal Energy Technology Center (FETC) and Department of Energy (DOE) involved in research and development of innovative remediation processes. These projects were to assist in the removal of barriers to development and commercialization of these new technologies. Studies of existing, underdeveloped technologies, were preferred to fundamental research into remediation technologies. Sound development of completely new technologies was preferred to minor improvements in existing methods. Solid technological improvements in existing technologies or significant cost reduction through innovative redesign were the preferred projects. Development, evaluation, and bench scale testing projects were preferred for the WVU research component. In the effort to fill gaps in current remediation technologies, the worth of the WVU Cooperative Agreement was proven. Two great technologies came out of the program. The Prefabricated Vertical Drain Technology for enhancing soil flushing was developed over the 6-year period and is presently being demonstrated on a 0.10 acre Trichloroethylene contaminated site in Ohio. The Spin

  18. A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba

    Energy Technology Data Exchange (ETDEWEB)

    Aiyama, H. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Nakai, K., E-mail: knakai@Neurosurg-tsukuba.com [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Yamamoto, T. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan)] [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Nariai, T. [Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyouku (Japan); Kumada, H. [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Ishikawa, E. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Isobe, T. [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Endo, K.; Takada, T.; Yoshida, F.; Shibata, Y.; Matsumura, A. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan)

    2011-12-15

    We have evaluated the efficacy and safety of boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor using a new protocol. One of the two patients enrolled in this trial is a man with recurrent glioblastoma and the other is a woman with anaplastic meningioma. Both are still alive and no severe adverse events have been observed. Our findings suggest that NCT will be safe as a palliative therapy for malignant brain tumors. - Highlights: Black-Right-Pointing-Pointer Boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor. Black-Right-Pointing-Pointer Two cases with recurrent glioblastoma and anaplastic meningioma. Black-Right-Pointing-Pointer No severe adverse events have been observed using BNCT. Black-Right-Pointing-Pointer BNCT has a possibility of a safe palliative therapy for malignant brain tumors.

  19. Federal Geothermal Research Program Update - Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Laney, P.T.

    2002-08-31

    This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  20. Heavy Truck Clean Diesel Cooperative Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Milam, David

    2006-12-31

    This report is the final report for the Department of Energy on the Heavy Truck Engine Program (Contract No. DE-FC05-00OR22806) also known as Heavy Truck Clean Diesel (HTCD) Program. Originally, this was scoped to be a $38M project over 5 years, to be 50/50 co-funded by DOE and Caterpillar. The program started in June 2000. During the program the timeline was extended to a sixth year. The program completed in December 2006. The program goal was to develop and demonstrate the technologies required to enable compliance with the 2007 and 2010 (0.2g/bhph NOx, 0.01g/bhph PM) on-highway emission standards for Heavy Duty Trucks in the US with improvements in fuel efficiency compared to today's engines. Thermal efficiency improvement from a baseline of 43% to 50% was targeted.

  1. Decontamination Systems Information and Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Cook, Echol E; Beatty, Tia Maria

    1998-07-01

    The following paragraphs comprise the research efforts during the second quarter of 1998 (April 1 - June 30.) These tasks have been granted a continuation until the end of August 1998. This report represents the last technical quarterly report deliverable for the WVU Cooperative Agreement - Decontamination Systems Information and Research Program. Final draft technical reports will be the next submission. During this period, work was completed on the Injection and Circulation of Potable Water Through PVDs on Task 1.6 - Pilot Scale Demonstration of TCE Flushing Through PVDs at the DOE/RMI Extrusion Plant. The data has been evaluated and representative graphs are presented. The plot of Cumulative Injected Volume vs. Cumulative Week Time show the ability to consistently inject through the two center PVDs at a rate of approximately ten (10) gallons per hour. This injection rate was achieved under a static head that varied from five (5) feet to three (3) feet. The plot of Extracted Flow Rate vs. Cumulative Week Time compares the extraction rate with and without the injection of water. The injection operation was continuous for eight hour periods while the extraction operation was executed over a pulsing schedule. Extraction rates as high as forty-five (45) gallons per hour were achieved in conjunction with injection (a 350% increase over no injection.) The retrieved TCE in the liquid phase varied to a considerable degree depending on the pulsing scheme, indicating a significant amount of stripping (volatilization) took place during the extraction process. A field experiment was conducted to confirm this. A liquid sample was obtained using the same vacuum system used in the pad operation and a second liquid sample was taken by a bailer. Analyzation of TCE concentration showed 99.5% volatilization when the vacuum system was used for extraction. This was also confirmed by data from the air monitoring program which indicated that 92%-99% of the retrieved TCE was being

  2. Integrated reliability program for Scout research vehicle.

    Science.gov (United States)

    Morris, B. V.; Welch, R. C.

    1967-01-01

    Integrated reliability program for Scout launch vehicle in terms of design specification, review functions, malfunction reporting, failed parts analysis, quality control, standardization and certification

  3. Calculation of Absorbed Dose in Target Tissue and Equivalent Dose in Sensitive Tissues of Patients Treated by BNCT Using MCNP4C

    Science.gov (United States)

    Zamani, M.; Kasesaz, Y.; Khalafi, H.; Pooya, S. M. Hosseini

    Boron Neutron Capture Therapy (BNCT) is used for treatment of many diseases, including brain tumors, in many medical centers. In this method, a target area (e.g., head of patient) is irradiated by some optimized and suitable neutron fields such as research nuclear reactors. Aiming at protection of healthy tissues which are located in the vicinity of irradiated tissue, and based on the ALARA principle, it is required to prevent unnecessary exposure of these vital organs. In this study, by using numerical simulation method (MCNP4C Code), the absorbed dose in target tissue and the equiavalent dose in different sensitive tissues of a patiant treated by BNCT, are calculated. For this purpose, we have used the parameters of MIRD Standard Phantom. Equiavelent dose in 11 sensitive organs, located in the vicinity of target, and total equivalent dose in whole body, have been calculated. The results show that the absorbed dose in tumor and normal tissue of brain equal to 30.35 Gy and 0.19 Gy, respectively. Also, total equivalent dose in 11 sensitive organs, other than tumor and normal tissue of brain, is equal to 14 mGy. The maximum equivalent doses in organs, other than brain and tumor, appear to the tissues of lungs and thyroid and are equal to 7.35 mSv and 3.00 mSv, respectively.

  4. U.S. Global Change Research Program Budget Crosscut

    Data.gov (United States)

    Office of Science and Technology Policy, Executive Office of the President — U.S. Global Change Research Program budget authority for Agency activities in which the primary focus is on:Observations, research, and analysis of climate change...

  5. Programs for Use in Teaching Research Methods for Small Computers

    Science.gov (United States)

    Halley, Fred S.

    1975-01-01

    Description of Sociology Library (SOLIB), presented as a package of computer programs designed for smaller computers used in research methods courses and by students performing independent research. (Author/ND)

  6. 76 FR 314 - Sorghum Promotion, Research, and Information Program: Referendum

    Science.gov (United States)

    2011-01-04

    ... Agricultural Marketing Service Sorghum Promotion, Research, and Information Program: Referendum AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of Opportunity to Participate in the Sorghum Promotion, Research, and Information Referendum. SUMMARY: The Agricultural Marketing Service (AMS) is announcing...

  7. Pacific Northwest Laboratory Alaska (ARCTIC) research program

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, W.C.; Eberhardt, L.E.

    1980-03-01

    The current program continues studies of arctic ecosystems begun in 1959 as part of the Cape Thompson Program. Specific ecosystem aspects include studies of the ecology of arctic and red foxes, small mammel and bird population studies, lichen studies, and radiation ecology studies. (ACR)

  8. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  9. Action Research: Effective Marketing Strategies for a Blended University Program

    Science.gov (United States)

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  10. 78 FR 12033 - Programs and Research Projects Affecting the Arctic

    Science.gov (United States)

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office ] ARCTIC RESEARCH COMMISSION Programs and Research Projects Affecting the Arctic Notice is hereby given that the U.S. Arctic Research...) Commissioners and staff reports (4) Discussion and presentations concerning Arctic research activities The...

  11. Preconference Educational Research Training Program in Music Education. Final Report.

    Science.gov (United States)

    Petzold, Robert; And Others

    The 1970 Preconference Educational Research Training Program (RTP) provided three 3-day sessions of intensive research training for a total of 160 music educators from across the country. The primary purpose of the RTP activity was to provide music education researchers and users of research with intensive training in three major areas (1)…

  12. Cooperative research program in coal liquefaction

    Energy Technology Data Exchange (ETDEWEB)

    Huffman, G.P. (ed.)

    1991-01-01

    This Quarterly Report on coal liquefaction research includes discussion in the areas of (1) Iron Based Catalysts for Coal Liquefaction; (2) Exploratory Research on Coal Conversion; (3) Novel Coal Liquefaction Concepts; (4) Novel Catalysts for Coal Liquefaction. (VC)

  13. Network for Translational Research - Cancer Imaging Program

    Science.gov (United States)

    Cooperative agreement (U54) awards to establish Specialized Research Resource Centers that will participate as members of a network of inter-disciplinary, inter-institutional research teams for the purpose of supporting translational research in optical imaging and/or spectroscopy in vivo, with an emphasis on multiple modalities.

  14. 77 FR 40590 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-07-10

    ... Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program; Disability... Rehabilitation Research Projects and Centers Program--Disability and Rehabilitation Research Projects--Burn Model... Rehabilitation Research Projects and Centers Program-- Disability and Rehabilitation Research...

  15. Laboratory Directed Research and Development Program: FY 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    SLAC,

    2016-04-04

    The Department of Energy (DOE) and the SLAC National Accelerator Laboratory (SLAC) encourage innovation, creativity, originality and quality to maintain the Laboratory’s research activities and staff at the forefront of science and technology. To further advance its scientific research capabilities, the Laboratory allocates a portion of its funds for the Laboratory Directed Research and Development (LDRD) program. With DOE guidance, the LDRD program enables SLAC scientists to make rapid and significant contributions that seed new strategies for solving important national science and technology problems. The LDRD program is conducted using existing research facilities.

  16. Lithium target for accelerator based BNCT neutron source: Influence by the proton irradiation on lithium

    Science.gov (United States)

    Fujii, R.; Imahori, Y.; Nakakmura, M.; Takada, M.; Kamada, S.; Hamano, T.; Hoshi, M.; Sato, H.; Itami, J.; Abe, Y.; Fuse, M.

    2012-12-01

    The neutron source for Boron Neutron Capture Therapy (BNCT) is in the transition stage from nuclear reactor to accelerator based neutron source. Generation of low energy neutron can be achieved by 7Li (p, n) 7Be reaction using accelerator based neutron source. Development of small-scale and safe neutron source is within reach. The melting point of lithium that is used for the target is low, and durability is questioned for an extended use at a high current proton beam. In order to test its durability, we have irradiated lithium with proton beam at the same level as the actual current density, and found no deterioration after 3 hours of continuous irradiation. As a result, it is suggested that lithium target can withstand proton irradiation at high current, confirming suitability as accelerator based neutron source for BNCT.

  17. Design of photon converter and photoneutron target for High power electron accelerator based BNCT.

    Science.gov (United States)

    Rahmani, Faezeh; Seifi, Samaneh; Anbaran, Hossein Tavakoli; Ghasemi, Farshad

    2015-12-01

    An electron accelerator, ILU-14, with current of 10 mA and 100 kW in power has been considered as one of the options for neutron source in Boron Neutron Capture Therapy (BNCT). The final design of neutron target has been obtained using MCNPX to optimize the neutron production. Tungsten in strip shape and D2O in cylindrical form have been proposed as the photon converter and the photoneutron target, respectively. In addition calculation of heat deposition in the photon target design has been considered to ensure mechanical stability of target. The results show that about 8.37×10(12) photoneutron/s with average energy of 615 keV can be produced by this neutron source design. In addition, using an appropriate beam shaping assembly an epithermal neutron flux of the order of 1.24×10(8) cm(-2) s(-1) can be obtained for BNCT applications.

  18. Towards the final BSA modeling for the accelerator-driven BNCT facility at INFN LNL

    Energy Technology Data Exchange (ETDEWEB)

    Ceballos, C. [Centro de Aplicaciones Tecnlogicas y Desarrollo Nuclear, 5ta y30, Miramar, Playa, Ciudad Habana (Cuba); Esposito, J., E-mail: juan.esposito@lnl.infn.it [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Agosteo, S. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Colautti, P.; Conte, V.; Moro, D. [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Pola, A. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy)

    2011-12-15

    Some remarkable advances have been made in the last years on the SPES-BNCT project of the Istituto Nazionale di Fisica Nucleare (INFN) towards the development of the accelerator-driven thermal neutron beam facility at the Legnaro National Laboratories (LNL), aimed at the BNCT experimental treatment of extended skin melanoma. The compact neutron source will be produced via the {sup 9}Be(p,xn) reactions using the 5 MeV, 30 mA beam driven by the RFQ accelerator, whose modules construction has been recently completed, into a thick beryllium target prototype already available. The Beam Shaping Assembly (BSA) final modeling, using both neutron converter and the new, detailed, Be(p,xn) neutron yield spectra at 5 MeV energy recently measured at the CN Van de Graaff accelerator at LNL, is summarized here.

  19. Near threshold ⁷Li(p,n) ⁷Be reaction as neutron source for BNCT.

    Science.gov (United States)

    Minsky, D M; Kreiner, A J

    2015-12-01

    (7)Li(p,n)(7)Be is an endothermic reaction and working near its threshold (1.88 MeV) has the advantage of neutron spectra with maximum energies of about 100 keV, considerably lower than at higher beam energies, or than using other neutron-producing reactions or as for the uranium fission spectrum, relevant for BNCT based on nuclear reactors. With this primary energy it is much easier to obtain the energies needed for treating deep seated tumors by BNCT (about 10 keV). This work studies bombarding energies up to 2.05 MeV, different beam incidence angles and the effect of the undesirable gamma production via the (7)Li(p,γp') (7)Li reaction.

  20. Hyaluronic acid as a potential boron carrier for BNCT: Preliminary evaluation.

    Science.gov (United States)

    Zaboronok, A; Yamamoto, T; Nakai, K; Yoshida, F; Uspenskii, S; Selyanin, M; Zelenetskii, A; Matsumura, Akira

    2015-12-01

    Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different biological tissues, has the potential to attach to CD44 receptors on the surface of certain cancer cells, where the receptor is overexpressed compared with normal cells. Boron-hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. BHA with low-viscosity 30 kDa HA could be administered by intravenous injection. The compound showed a certain degree of cytotoxicity and accumulation in C6 rat glioma cells in vitro. Instability of the chelate bonds between boron and HA and/or insufficient specificity of CD44 receptors on C6 cells to BHA could account for the insufficient in vitro accumulation. To ensure the future eligibility of BHA for BNCT experiments, using alternative tumor cell lines and chemically securing the chelate bonds or synthesizing BHA with boron covalently attached to HA might be required.

  1. Designing of the 14 MeV neutron moderator for BNCT

    Institute of Scientific and Technical Information of China (English)

    CHENG Dao-Wen; LU Jing-Bin; YANG Dong; LIU Yu-Min; WANG Hui-Dong; MA Ke-Yan

    2012-01-01

    In boron neutron capture therapy (BNCT),the ratio of the fast neutron flux to the neutron flux in the tumor (RFNT) must be less than 3%.If a D-T neutron generator is used in BNCT,the 14 MeV neutron moderator must be optimized to reduce the RFNT.Based on the neutron moderation theory and the simulation results,tungsten,lead and diamond were used to moderate the 14 MeV neutrons.Satisfying RFNT of less than 3%,the maximum neutron flux in the tumor was achieved with a three-layer moderator comprised of a 3 cm thick tungsten layer,a 14 cm thick lead layer and a 21 cm thick diamond layer.

  2. A feasibility design study on a neutron spectrometer for BNCT with liquid moderator.

    Science.gov (United States)

    Tamaki, S; Sato, F; Murata, I

    2015-12-01

    Neutrons generated by accelerators have various energy spectra. However, only limited methods are available to measure the whole neutron energy spectrum, especially when including the epithermal region that is normally used in BNCT. In the present study, we carried out the design study on a new neutron spectrometer that can measure such a neutron spectrum more accurately, precisely and with higher energy resolution, using an unfolding technique and a liquid moderator.

  3. Treatment planning capability assessment of a beam shaping assembly for accelerator-based BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, M.S., E-mail: herrera@tandar.cnea.gov.ar [Comision Nacional de Energia Atomica, CNEA, Av. Gral. Paz 1499, San Martin (Argentina)] [Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, Av. Rivadavia 191, Buenos Aires (Argentina)] [Universidad Nacional de San Martin, UNSAM, Av. 25 de Mayo y Francia Buenos Aires (Argentina); Gonzalez, S.J. [Comision Nacional de Energia Atomica, CNEA, Av. Gral. Paz 1499, San Martin (Argentina)] [Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, Av. Rivadavia 191, Buenos Aires (Argentina); Burlon, A.A. [Comision Nacional de Energia Atomica, CNEA, Av. Gral. Paz 1499, San Martin (Argentina)] [Universidad Nacional de San Martin, UNSAM, Av. 25 de Mayo y Francia Buenos Aires (Argentina); Minsky, D.M.; Kreiner, A.J. [Comision Nacional de Energia Atomica, CNEA, Av. Gral. Paz 1499, San Martin (Argentina)] [Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET, Av. Rivadavia 191, Buenos Aires (Argentina)] [Universidad Nacional de San Martin, UNSAM, Av. 25 de Mayo y Francia Buenos Aires (Argentina)

    2011-12-15

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) a theoretical study was performed to assess the treatment planning capability of different configurations of an optimized beam shaping assembly for such a facility. In particular this study aims at evaluating treatment plans for a clinical case of Glioblastoma.

  4. Infectious Disease Clinical Research Program (IDCRP)

    Data.gov (United States)

    Federal Laboratory Consortium — Our mission is to conduct infectious disease clinical research of importance to the military through a unique, adaptive, and collaborative network, to inform health...

  5. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  6. Characterisation of an accelerator-based neutron source for BNCT versus beam energy

    Science.gov (United States)

    Agosteo, S.; Curzio, G.; d'Errico, F.; Nath, R.; Tinti, R.

    2002-01-01

    Neutron capture in 10B produces energetic alpha particles that have a high linear energy transfer in tissue. This results in higher cell killing and a higher relative biological effectiveness compared to photons. Using suitably designed boron compounds which preferentially localize in cancerous cells instead of healthy tissues, boron neutron capture therapy (BNCT) has the potential of providing a higher tumor cure rate within minimal toxicity to normal tissues. This clinical approach requires a thermal neutron source, generally a nuclear reactor, with a fluence rate sufficient to deliver tumorcidal doses within a reasonable treatment time (minutes). Thermal neutrons do not penetrate deeply in tissue, therefore BNCT is limited to lesions which are either superficial or otherwise accessible. In this work, we investigate the feasibility of an accelerator-based thermal neutron source for the BNCT of skin melanomas. The source was designed via MCNP Monte Carlo simulations of the thermalization of a fast neutron beam, generated by 7 MeV deuterons impinging on a thick target of beryllium. The neutron field was characterized at several deuteron energies (3.0-6.5 MeV) in an experimental structure installed at the Van De Graaff accelerator of the Laboratori Nazionali di Legnaro, in Italy. Thermal and epithermal neutron fluences were measured with activation techniques and fast neutron spectra were determined with superheated drop detectors (SDD). These neutron spectrometry and dosimetry studies indicated that the fast neutron dose is unacceptably high in the current design. Modifications to the current design to overcome this problem are presented.

  7. In-phantom dosimetry for BNCT with Fricke and normoxic-polymer gels

    Science.gov (United States)

    Gambarini, G.; Agosteo, S.; Carrara, M.; Gay, S.; Mariani, M.; Pirola, L.; Vanossi, E.

    2006-05-01

    Measurements of in-phantom dose distributions and images are important for Boron Neutron Capture Therapy treatment planning. The method for spatial determination of absorbed doses in thermal or epithermal neutron fields, based on Fricke-xylenol-orange-infused gel dosimeters in form of layers, has revealed to be very reliable, as gel layer dosimeters give the possibility of obtaining spatial dose distributions and measurements of each dose contribution in neutron fields, by means of a properly studied procedure. Quite recently, BNCT has been applied to treat liver metastases; in this work the results of in-phantom dosimetry for explanted liver in BNCT treatments are described. Moreover, polyacrylamide gel (PAG) dosimeters in which a polymerization process appears as a consequence of absorbed dose, have been recently tested, because of their characteristic absence of diffusion. In fact, due to the diffusion of ferric ions, Fricke-gel dosimeters require prompt analysis after exposure to avoid spatial information loss. In this work the preliminary results of a study about the reliability of polymer gel in BNCT dosimetry are also discussed. Gel layers have been irradiated in a phantom exposed in the thermal column of the TRIGA MARK II reactor (Pavia). The results obtained with the two kinds of gel dosimeter have been compared.

  8. Effective dose evaluation for BNCT brain tumor treatment based on voxel phantoms.

    Science.gov (United States)

    Wang, Jeng-Ning; Lee, Kuo-Wei; Jiang, Shiang-Huei

    2014-06-01

    For BNCT treatments, in addition to tumor target doses, non-negligible doses will result in all the remaining organs of the body. This work aims to evaluate the effective dose as well as the average absorbed doses of each of organs of patients with brain tumor treated in the BNCT epithermal neutron beam at THOR. The effective doses were evaluated according to the definitions of ICRP Publications 60 and 103 for the reference male and female computational phantoms developed in ICRP Publication 110 by using the MCNP5 Monte Carlo code with the THOR-Y09 beam source. The effective dose acquired in this work was compared with the results of our previous work calculated for an adult hermaphrodite mathematical phantom. It was found that the effective dose for the female voxel phantom is larger than that for the male voxel phantom by a factor of 1.2-1.5 and the effective dose for the voxel phantom is larger than that for the mathematical phantom by a factor of 1.3-1.6. For a typical brain tumor BNCT, the effective dose was calculated to be 1.51Sv and the average absorbed dose for eye lenses was 1.07Gy.

  9. Continuation of a Postdoctoral Research Associateship Program

    Science.gov (United States)

    1998-12-01

    from a professional post: Research Associate Position at Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires...of caffeine on human physical and mental performance (see Research in Progress below), preparation of an invited review article using the novel knee

  10. ANSTO - Program of Research 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO`s scientific and engineering activities is also included. ills.

  11. Fiscal year 1978 program of research

    Energy Technology Data Exchange (ETDEWEB)

    Linville, B. (ed.)

    1978-01-01

    The responsibilities of the Bartlesville Energy Research Center in the areas of advanced research on coal, enhanced oil recovery, drilling and offshore technology, product characterization, enhanced gas recovery, waste oil recycling, and alternative fuels are briefly reviewed and the progress made indicated. (JSR)

  12. Boron neutron capture therapy (BNCT) for the treatment of spontaneous nasal planum squamous cell carcinoma in felines.

    Science.gov (United States)

    Trivillin, Verónica A; Heber, Elisa M; Rao, Monica; Cantarelli, María A; Itoiz, Maria E; Nigg, David W; Calzetta, Osvaldo; Blaumann, Herman; Longhino, Juan; Schwint, Amanda E

    2008-02-01

    Recently, Boron neutron capture therapy (BNCT) was successfully applied to treat experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa, with no damage to normal tissue. It was also shown that treating spontaneous nasal planum SCC in terminal feline patients with low dose BNCT is safe and feasible. In an extension of this work, the present study aimed at evaluation of the response of tumor and dose-limiting normal tissues to potentially therapeutic BNCT doses. Biodistribution studies with (10)B-boronophenylalanine (BPA enriched in (10)B) as a (10)B carrier were performed on three felines that showed advanced nasal planum SCC without any standard therapeutic option. Following the biodistribution studies, BNCT mediated by (10)BPA was done using the thermalized epithermal neutron beam at the RA-6 Nuclear Reactor. Follow-up included clinical evaluation, assessment of macroscopic tumor and normal tissue response and biopsies for histopathological analysis. The treated animals did not show any apparent radiation-induced toxicity. All three animals exhibited partial tumor control and an improvement in clinical condition. Enhanced therapeutic efficacy was associated with a high (10)B content of the tumor and a small tumor size. BNCT is therefore believed to be potentially effective in the treatment of spontaneous SCC. However, improvement in targeting (10)B into all tumor cells and delivering a sufficient dose at a greater depth are still required for the treatment of deep-seated, large tumors. Future studies are needed to evaluate the potential efficacy of the dual mode cellular (e.g. BPA-BNCT) and vascular (e.g. GB-10-BNCT) targeting protocol in a preclinical scenario, employing combinations of (10)B compounds with different properties and complementary uptake mechanisms.

  13. The NASA computer science research program plan

    Science.gov (United States)

    1983-01-01

    A taxonomy of computer science is included, one state of the art of each of the major computer science categories is summarized. A functional breakdown of NASA programs under Aeronautics R and D, space R and T, and institutional support is also included. These areas were assessed against the computer science categories. Concurrent processing, highly reliable computing, and information management are identified.

  14. A Research Program in Computer Technology

    Science.gov (United States)

    1990-12-31

    systlems. The initial program applications included anl autonomous land vehicle. a pilot’s associate. andl a carrier battle group hattle management system...and Internet connectivity (Telnet). The environment provided by thebe jiodes and server-, conceals the fine-grain detail from outside users; users

  15. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    Science.gov (United States)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  16. The second workshop of neutron science research program

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Hideshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Tone, Tatsuzo [eds.

    1997-11-01

    The Japan Atomic Energy Research Institute(JAERI) has been proposing the Neutron Science Research Program to explore a broad range of basic research and the nuclear technology including actinide transmutation with use of powerful spallation neutron sources. For this purpose, the JAERI is conducting the research and development of an intense proton linac, the development of targets, as well as the conceptual design study of experimental facilities required for applications of spallation neutrons and secondary particle beams. The Special Task Force for Neutron Science Initiative was established in May 1996 to promote aggressively and systematically the Neutron Science Research Program. The second workshop on neutron science research program was held at the JAERI Tokai Research Establishment on 13 and 14 March 1997 for the purpose of discussing the results obtained since the first workshop in March 1996. The 27 of the presented papers are indexed individually. (J.P.N.)

  17. Human Genome Program Report. Part 2, 1996 Research Abstracts

    Science.gov (United States)

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  18. Human genome program report. Part 2, 1996 research abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  19. A research Program in Elementary Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Sobel, Henry; Molzon, William; Lankford, Andrew; Taffard, Anyes; Whiteson, Daniel; Kirkby, David

    2013-07-25

    Work is reported in: Neutrino Physics, Cosmic Rays and Elementary Particles; Particle Physics and Charged Lepton Flavor Violation; Research in Collider Physics; Dark Energy Studies with BOSS and LSST.

  20. Review of Defense Display Research Programs

    Science.gov (United States)

    2001-01-01

    Programs Flat Panel Autostereoscopic N-perspective 3D High Definition DMD Digital Projector Light Piping & Quantum Cavity Displays Solid State Laser...Megapixel Displays • Size Commonality • 67 % Weight Reduction • > 200 sq. in. per Display 20-20 Vision Simulators True 3D , sparse symbols Foldable Display...megapixel 2D and True 3D Display Technology 25M & T3D FY02-FY06 New service thrusts

  1. NASA/ASEE Faculty Fellowship Program: 2003 Research Reports

    Science.gov (United States)

    Kotnour, Tim (Editor); LopezdeCastillo, Eduardo (Editor)

    2003-01-01

    This document is a collection of technical reports on research conducted by the participants in the 2003 NASA/ASEE Faculty Fellowship Program at the John F. Kennedy Space Center (KSC). This was the nineteenth year that a NASA/ASEE program has been conducted at KSC. The 2003 program was administered by the University of Central Florida (UCF) in cooperation with KSC. The program was operated under the auspices of the American Society for Engineering Education (ASEE) and the Education Division, NASA Headquarters, Washington, D.C. The KSC program was one of nine such Aeronautics and Space Research Programs funded by NASA Headquarters in 2003. The basic common objectives of the NASA/ASEE Faculty Fellowship Program are: A) To further the professional knowledge of qualified engineering and science faculty members; B) To stimulate an exchange of ideas between teaching participants and employees of NASA; C) To enrich and refresh the research and teaching activities of participants institutions; D) To contribute to the research objectives of the NASA center. The KSC Faculty Fellows spent ten weeks (May 19 through July 25, 2003) working with NASA scientists and engineers on research of mutual interest to the university faculty member and the NASA colleague. The editors of this document were responsible for selecting appropriately qualified faculty to address some of the many research areas of current interest to NASA/KSC. A separate document reports on the administrative aspects of the 2003 program. The NASA/ASEE program is intended to be a two-year program to allow in-depth research by the university faculty member. In many cases a faculty member has developed a close working relationship with a particular NASA group that had provided funding beyond the two-year limit.

  2. Overview of NASA's space radiation research program.

    Science.gov (United States)

    Schimmerling, Walter

    2003-06-01

    NASA is developing the knowledge required to accurately predict and to efficiently manage radiation risk in space. The strategy employed has three research components: (1) ground-based simulation of space radiation components to develop a science-based understanding of radiation risk; (2) space-based measurements of the radiation environment on planetary surfaces and interplanetary space, as well as use of space platforms to validate predictions; and, (3) implementation of countermeasures to mitigate risk. NASA intends to significantly expand its support of ground-based radiation research in line with completion of the Booster Applications Facility at Brookhaven National Laboratory, expected in summer of 2003. A joint research solicitation with the Department of Energy is under way and other interagency collaborations are being considered. In addition, a Space Radiation Initiative has been submitted by the Administration to Congress that would provide answers to most questions related to the International Space Station within the next 10 years.

  3. University Research Initiative Program for Combat Readiness

    Science.gov (United States)

    1999-05-01

    APPROVED FOR PUBLIC RELEASE 13. ABSTRACT (Maximum 200 words) This research project involves a systematic investigation of novel methods for...maximize the impact on the mosquito vector while minimizing the impact on human health. Molecular systematic and molecular physiological approaches...insect orders ( Lepidoptera , Diptera, Coleoptera, Hemiptera, Hymenoptera). This analysis revealed considerable divergence among the OBPs, but that the

  4. Northeast Cooperative Research Study Fleet (SF) Program Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Northeast Cooperative Research Study Fleet (SF) Program partners with a subset of commercial fishermen to collect high quality, high resolution, haul by haul...

  5. Heavy liquid metals: Research programs at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Y.

    1996-06-01

    The author describes work at PSI on thermohydraulics, thermal shock, and material tests for mechnical properties. In the presentation, the focus is on two main programs. (1) SINQ LBE target: The phase II study program for SINQ is planned. A new LBE loop is being constructed. The study has the following three objectives: (a) Pump study - design work on an electromagnetic pump to be integrated into the target. (b) Heat pipe performance test - the use of heat pipes as an additional component of the target cooling system is being considered, and it may be a way to futher decouple the liquid metal and water coolant loops. (c) Mixed convection experiment - in order to find an optimal configuration of the additional flow guide for window cooling, mixed convection around the window is to be studied. The experiment will be started using water and then with LBE. (2) ESS Mercury target: For ESS target study, the following experimental studies are planned, some of which are exampled by trial experiments. (a) Flow around the window: Flow mapping around the hemi-cylindrical window will be made for optimising the flow channels and structures, (b) Geometry optimisation for minimizing a recirculation zone behind the edge of the flow separator, (c) Flow induced vibration and buckling problem for a optimised structure of the flow separator and (d) Gas-liquid two-phase flow will be studied by starting to establish the new experimental method of measuring various kinds of two-phase flow characteristics.

  6. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Ronald C.

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described. (MOW)

  7. Environmental Biotechnology Research and Development Program 1989-1992

    NARCIS (Netherlands)

    Brinkman J; Rulkens WH; Visscher K

    1989-01-01

    This report is an English translation of the Dutch Research and Development Program on environmental biotechnology 1989-1992. In this program an overview is given of the recent developments in environmental biotechnology. Based on this overview, the possibilities of biotechnology for management

  8. Program Evaluation and Research Designs. NBER Working Paper No. 16016

    Science.gov (United States)

    DiNardo, John; Lee, David S.

    2010-01-01

    This chapter provides a selective review of some contemporary approaches to program evaluation. One motivation for our review is the recent emergence and increasing use of a particular kind of "program" in applied microeconomic research, the so-called Regression Discontinuity (RD) Design of Thistlethwaite and Campbell (1960). We organize our…

  9. The Practice and Promise of Prison Programming. Research Report.

    Science.gov (United States)

    Lawrence, Sarah; Mears, Daniel P.; Dubin, Glenn; Travis, Jeremy

    This study focused on employment-related programs in prison, exploring what the research literature tells about the effectiveness of prison-based education, vocational training, and prison industry on postrelease outcomes. Also studied was the state of practice of such programs and strategic opportunities for improving existing employment-related…

  10. Next Steps for Research and Practice in Career Programming

    Science.gov (United States)

    Hynes, Kathryn

    2012-01-01

    Career programming is a useful framework for thinking about how to support youth development across schools and multiple out-of-school-time contexts. The articles in this issue of "New Directions for Youth Development" highlight the broad research base relevant to career programming from which policy and practice can draw. This concluding article…

  11. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  12. U.S. Nuclear Regulatory Commission natural analogue research program

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, L.A.; Ott, W.R. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process.

  13. The role of research in NRC regulatory programs

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S.A.

    1996-03-01

    This article is the text of the opening remarks by NRC Chairwoman Shirley Jackson to the Reactor Safety Meeting. In her remarks, Dr. Jackson discusses the role of research in NRC regulatory programs and points out by way of example that many of the research programs provide considerable benefit to the industry as well as to the Commission. She then outlines current activities as well as future plans.

  14. 77 FR 20802 - Applications for New Awards; Education Research and Special Education Research Grant Programs...

    Science.gov (United States)

    2012-04-06

    ... Learning Programs and Policies English Learners Postsecondary and Adult Education Education Technology 84... three competitions contained errors: Research on Statistical and Research Methodology in Education (CFDA... Learning Effective Teachers and Effective Teaching Social and Behavioral Context for Academic...

  15. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Maxwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1990-02-01

    This report summarizes three documents: Multiyear Research Plan, Volume I FY 1989 Task Reports, and Volume II Appendices. These documents describe tasks that were undertaken from November 1988 to December 1989, the first year of the project. Those tasks were: (1) the formation of a steering committee, (2) the development of a multiyear research plan, (3) analysis of the US industrialized housing industry, (4) assessment of foreign technology, (5) assessment of industrial applications, (6) analysis of computerized design and evaluation tools, and (7) assessment of energy performance of baseline and advanced industrialized housing concepts. While this document summarizes information developed in each task area, it doesn't review task by task, as Volume I FY 1989 Task Reports does, but rather treats the subject of energy efficient industrialized housing as a whole to give the reader a more coherent view. 7 figs., 9 refs.

  16. Coordinated Research Program in Pulsed Power Physics.

    Science.gov (United States)

    1984-12-20

    fast transition from the low-imped- for HVDC circuit breakers ," Electric Power Research Institute ance reflex mode ("closed" switch) to the much higher...conventional circuit breakers may help to understand the i-Frrimiton of plasma laver along insulator 2-Plasma cooling processes in this type of opening...commerciallv available circuit pI At A7A breakers for long charging times and a fuse for fast opening has been operated successfully [52], [58]. A t

  17. Coordinated Research Program in Pulsed Power Physics.

    Science.gov (United States)

    1987-02-16

    Insulated High Current Ion Source" November 21, 1985 Chemical and Nuclear Engineering University of New Mexico Albuquerque, NM 14. Hriar S. Cabayan...hon tachment rate co efficients." %; in ri. 1 2]. he swtch hambr isAlong with these considerations, ,.L filled with a gas of pressures of I several...nergative differentia. d) Permnent Address Mission Research conductivity [(’ 4] Sur?, a charecipristi 1s Corporation. Albuquerque he Mexico USA

  18. Air Force Engineering Research Initiation Grant Program

    Science.gov (United States)

    1994-06-21

    Wisconsin "Investigation of the Role of Structure in the Dynamic Response of Electrorheological Suspensions" RI-B-92-08 Prof. Yozo Mikata Old Dominion...on a direct output feedback control law. In this study, piezoelectric ceramic elements were used as both actuator and sensor. The rod vibration was... ELECTRORHEOLOGICAL SUSPENSIONS FINAL REPORT Air Force Engineering Research Initiation Grant RI-B-92-07 D. J. Klingenberg Department of Chemical

  19. Coconut Program Area Research Planning and Prioritization

    OpenAIRE

    Aragon, Corazon

    2000-01-01

    The coconut industry is one of the country's major pillars in employment generation and foreign exchange earnings. However, local production problems, the expansion in coconut hectarage of neighboring countries, and recent developments in biotechnology research on other competing crops that have high lauric oil content might affect its long-term sustainability and viability. In a highly liberalized global trade environment, innovation and creativity in the country's coconut industry are neede...

  20. Defense Nanotechnology Research and Development Programs

    Science.gov (United States)

    2005-05-17

    that can be dyed to match specific patterns and woven into uniforms. • An electrospun fiberized adhesive has been developed for fabric laminates...150 by 30 crossbars ). • High moment, magnetic nano-tags have been fabricated that allow DNA fingerprinting without DNA amplification (i.e., the... learned , and DoD guidance is critical to assure both the optimum direction of ongoing research efforts and the optimum leveraging of this knowledge to

  1. National Research Council Resident Research Associateship (NRC-RRA) program

    Science.gov (United States)

    1988-08-01

    Fisico dell’ Universita di Napoli Mostra D’Oltremare Pad. 19 80125 Napoli Italy 8. N/A 9. Tucson, AZ, 6-7 April 1987, NSO Senior Staff Meeting 10. Santa...progress: Fatigue crack growth tests on a nickel-base superalloy at ambient ard elevated temperatures. 15. Summary of research during tenure: FA

  2. Danish Integrated Antimicrobial Resistance Monitoring and Research Program

    Science.gov (United States)

    Heuer, Ole E.; Emborg, Hanne-Dorthe; Bagger-Skjøt, Line; Jensen, Vibeke F.; Rogues, Anne-Marie; Skov, Robert L.; Agersø, Yvonne; Brandt, Christian T.; Seyfarth, Anne Mette; Muller, Arno; Hovgaard, Karin; Ajufo, Justin; Bager, Flemming; Aarestrup, Frank M.; Frimodt-Møller, Niels; Wegener, Henrik C.; Monnet, Dominique L.

    2007-01-01

    Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries. PMID:18217544

  3. Incorporating resident research into the dermatology residency program

    Directory of Open Access Journals (Sweden)

    Wagner RF Jr

    2013-04-01

    Full Text Available Richard F Wagner Jr, Sharon S Raimer, Brent C Kelly Department of Dermatology, The University of Texas Medical Branch, Galveston, Texas, USA Abstract: Programmatic changes for the dermatology residency program at The University of Texas Medical Branch were first introduced in 2005, with the faculty goal incorporating formal dermatology research projects into the 3-year postgraduate training period. This curriculum initially developed as a recommendation for voluntary scholarly project activity by residents, but it evolved into a program requirement for all residents in 2009. Departmental support for this activity includes assignment of a faculty mentor with similar interest about the research topic, financial support from the department for needed supplies, materials, and statistical consultation with the Office of Biostatistics for study design and data analysis, a 2-week elective that provides protected time from clinical activities for the purpose of preparing research for publication and submission to a peer-reviewed medical journal, and a departmental award in recognition for the best resident scholarly project each year. Since the inception of this program, five classes have graduated a total of 16 residents. Ten residents submitted their research studies for peer review and published their scholarly projects in seven dermatology journals through the current academic year. These articles included three prospective investigations, three surveys, one article related to dermatology education, one retrospective chart review, one case series, and one article about dermatopathology. An additional article from a 2012 graduate about dermatology education has also been submitted to a journal. This new program for residents was adapted from our historically successful Dermatology Honors Research Program for medical students at The University of Texas Medical Branch. Our experience with this academic initiative to promote dermatology research by

  4. Online Financial Education Programs: Theory, Research, and Recommendations

    Directory of Open Access Journals (Sweden)

    Jinhee Kim

    2017-03-01

    Full Text Available Technological advances have created unprecedented opportunities for online financial education that can be used to improve financial literacy and money management practices. While online financial education programs have become popular, relevant research and theoretical frameworks have rarely been considered in the development of such programs. This article synthesizes lessons from literature and theories for the development of an effective online financial education program. Drawing from literature on financial literacy education and online education, implications and recommendations for integrating technology into online financial education programs for adults are discussed.

  5. Supporting medical education research quality: the Association of American Medical Colleges' Medical Education Research Certificate program.

    Science.gov (United States)

    Gruppen, Larry D; Yoder, Ernie; Frye, Ann; Perkowski, Linda C; Mavis, Brian

    2011-01-01

    The quality of the medical education research (MER) reported in the literature has been frequently criticized. Numerous reasons have been provided for these shortcomings, including the level of research training and experience of many medical school faculty. The faculty development required to improve MER can take various forms. This article describes the Medical Education Research Certificate (MERC) program, a national faculty development program that focuses exclusively on MER. Sponsored by the Association of American Medical Colleges and led by a committee of established medical education researchers from across the United States, the MERC program is built on a set of 11 interactive workshops offered at various times and places across the United States. MERC participants can customize the program by selecting six workshops from this set to fulfill requirements for certification. This article describes the history, operations, current organization, and evaluation of the program. Key elements of the program's success include alignment of program content and focus with needs identified by prospective users, flexibility in program organization and logistics to fit participant schedules, an emphasis on practical application of MER principles in the context of the participants' activities and interests, consistency in program content and format to ensure standards of quality, and a sustainable financial model. The relationship between the national MERC program and local faculty development initiatives is also described. The success of the MERC program suggests that it may be a possible model for nationally disseminated faculty development programs in other domains.

  6. State Preschool Program Evaluations and Research: Research-to-Policy Resources

    Science.gov (United States)

    Ferguson, Daniel

    2016-01-01

    Many states with preschool programs, as well as other interested organizations and individuals, have undertaken research and evaluation efforts to improve their understanding of state preschool program implementation, results, and impacts. A 2004 review by Gilliam and Zigler examined state efforts to evaluate preschool programs from 1997 to 2003.…

  7. Research and technology operating plan summary: Fiscal year 1975 research and technology program. [space programs, energy technology, and aerospace sciences

    Science.gov (United States)

    1975-01-01

    Summaries are presented of Research and Technology Operating Plans currently in progress throughout NASA. Citations and abstracts of the operating plans are presented along with a subject index, technical monitor index, and responsible NASA organization index. Research programs presented include those carried out in the Office of Aeronautics and Space Technology, Office of Energy Programs, Office of Applications, Office of Space Sciences, Office of Tracking and Data Acquisition, and the Office of Manned Space Flight.

  8. Laboratory Directed Research and Development Program Assessment for FY 2008

    Energy Technology Data Exchange (ETDEWEB)

    Looney, J P; Fox, K J

    2008-03-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary Laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal Year 2008 spending was $531.6 million. There are approximately 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. To be a premier scientific Laboratory, BNL must continuously foster groundbreaking scientific research and renew its research agenda. The competition for LDRD funds stimulates Laboratory scientists to think in new and creative ways, which becomes a major factor in achieving and maintaining research excellence and a means to address National needs within the overall mission of the DOE and BNL. By fostering high-risk, exploratory research, the LDRD program helps

  9. Application of Logic Models in a Large Scientific Research Program

    Science.gov (United States)

    O'Keefe, Christine M.; Head, Richard J.

    2011-01-01

    It is the purpose of this article to discuss the development and application of a logic model in the context of a large scientific research program within the Commonwealth Scientific and Industrial Research Organisation (CSIRO). CSIRO is Australia's national science agency and is a publicly funded part of Australia's innovation system. It conducts…

  10. Overview of the Hemostasis Research Program: Advances and Future Directions

    Science.gov (United States)

    2004-09-01

    advanced to treat such an injury in the field. The hypothesis was that a hemostatic material could be infused into a closed body cavity by a trocar ...Research Program of the US Army Medical Research and Material Command is to reduce the morbidity and mortality resulting from injuries on the

  11. Study of Impacts of Small Business Innovation Research Programs

    Institute of Scientific and Technical Information of China (English)

    CAO Yong-hui

    2008-01-01

    The development and commercialization of new technologies are important to the global economy. In this paper, the author first addresses Small Business Innovation Research (SBIR) background; then, implicitly defines SBIR; finally, I also analyze the intpacts of small business innovation research programs. There are four aspects: entrepreneurial orientation; environmental factors; organizational factors and performance.

  12. TNO Early Research Program 2015-2018 : annual plan 2016

    NARCIS (Netherlands)

    Wapenaar, K.E.D.

    2015-01-01

    The Early Research Program presented here reflects TNO’s vision where to put our innovative research efforts in the coming years, so to be able to maintain and grow strong technology positions and to contribute, together with knowledge partners and stakeholders, to several grand challenges. The majo

  13. TNO Early Research Program 2015-2018 : annual plan 2015

    NARCIS (Netherlands)

    Wapenaar, K.E.D.

    2014-01-01

    The Early Research Program presented here reflects TNO’s vision where to put our innovative research efforts in the coming years, so to be able to maintain and grow strong technology positions and to contribute, together with knowledge partners and stakeholders, to several grand challenges. The majo

  14. NCI Community Oncology Research Program Approved | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |

  15. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Mazwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1989-12-01

    This document describes the research work completed in five areas in fiscal year 1989. (1) The analysis of the US industrialized housing industry includes statistics, definitions, a case study, and a code analysis. (2) The assessment of foreign technology reviews the current status of design, manufacturing, marketing, and installation of industrialized housing primarily in Sweden and Japan. (3) Assessment of industrialization applications reviews housing production by climate zone, has a cost and energy comparison of Swedish and US housing, and discusses future manufacturing processes and emerging components. (4) The state of computer use in the industry is described and a prototype design tool is discussed. (5) Side by side testing of industrialized housing systems is discussed.

  16. Sandia Combustion Research Program: Annual report, 1986

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This report presents research results of the past year, divided thematically into some ten categories. Publications and presentations arising from this work are included in the appendix. Our highlighted accomplishment of the year is the announcement of the discovery and demonstration of the RAPRENOx process. This new mechanism for the elimination of nitrogen oxides from essentially all kinds of combustion exhausts shows promise for commercialization, and may eventually make a significant contribution to our nation's ability to control smog and acid rain. The sections of this volume describe the facility's laser and computer system, laser diagnostics of flames, combustion chemistry, reacting flows, liquid and solid propellant combustion, mathematical models of combustion, high-temperature material interfaces, studies of engine/furnace combustion, coal combustion, and the means of encouraging technology transfer. 182 refs., 170 figs., 12 tabs.

  17. Solar heating and cooling commercialization research program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, D.L.; Tragert, W.; Weir, S.

    1979-11-01

    The Solar Heating and Cooling Commercialization Research Program has addressed a recognized need to accelerate the commercialization of solar products. The development of communication techniques and materials for a target group of heating, ventilating and air-conditioning (HVAC) wholesalers and distributors has been the primary effort. A summary of the program, the approach to the development of the techniques and materials, the conclusions derived from seminar feedback, the development of additional research activities and reports and the recommendations for follow-on activities are presented. The appendices offer detailed information on specific elements of the research effort.

  18. Air Breathing Propulsion Controls and Diagnostics Research at NASA Glenn Under NASA Aeronautics Research Mission Programs

    Science.gov (United States)

    Garg, Sanjay

    2015-01-01

    The Intelligent Control and Autonomy Branch (ICA) at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet the goals of the NASA Aeronautics Research Mission Directorate (ARMD) Programs. These efforts are primarily under the various projects under the Advanced Air Vehicles Program (AAVP), Airspace Operations and Safety Program (AOSP) and Transformative Aeronautics Concepts Program (TAC). The ICA Branch is focused on advancing the state-of-the-art of aero-engine control and diagnostics technologies to help improve aviation safety, increase efficiency, and enable operation with reduced emissions. This paper describes the various ICA research efforts under the NASA Aeronautics Research Mission Programs with a summary of motivation, background, technical approach, and recent accomplishments for each of the research tasks.

  19. Research on teacher education programs: logic model approach.

    Science.gov (United States)

    Newton, Xiaoxia A; Poon, Rebecca C; Nunes, Nicole L; Stone, Elisa M

    2013-02-01

    Teacher education programs in the United States face increasing pressure to demonstrate their effectiveness through pupils' learning gains in classrooms where program graduates teach. The link between teacher candidates' learning in teacher education programs and pupils' learning in K-12 classrooms implicit in the policy discourse suggests a one-to-one correspondence. However, the logical steps leading from what teacher candidates have learned in their programs to what they are doing in classrooms that may contribute to their pupils' learning are anything but straightforward. In this paper, we argue that the logic model approach from scholarship on evaluation can enhance research on teacher education by making explicit the logical links between program processes and intended outcomes. We demonstrate the usefulness of the logic model approach through our own work on designing a longitudinal study that focuses on examining the process and impact of an undergraduate mathematics and science teacher education program.

  20. Federal Geothermal Research Program Update Fiscal Year 1999

    Energy Technology Data Exchange (ETDEWEB)

    2004-02-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal and Wind Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The following mission and goal statements guide the overall activities of the Office of Geothermal and Wind Technologies. This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 1999. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal and Wind Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  1. Setting a research agenda to inform intensive comprehensive aphasia programs.

    Science.gov (United States)

    Hula, William D; Cherney, Leora R; Worrall, Linda E

    2013-01-01

    Research into intensive comprehensive aphasia programs (ICAPs) has yet to show that this service delivery model is efficacious, effective, has cost utility, or can be broadly implemented. This article describes a phased research approach to the study of ICAPs and sets out a research agenda that considers not only the specific issues surrounding ICAPs, but also the phase of the research. Current ICAP research is in the early phases, with dosing and outcome measurement as prime considerations as well as refinement of the best treatment protocol. Later phases of ICAP research are outlined, and the need for larger scale collaborative funded research is recognized. The need for more rapid translation into practice is also acknowledged, and the use of hybrid models of phased research is encouraged within the ICAP research agenda.

  2. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  3. Laboratory Directed Research and Development Program FY2004

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd C.

    2005-03-22

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Goals that are codified in DOE's September 2003 Strategic Plan, with a primary focus on Advancing Scientific Understanding. For that goal, the Fiscal Year (FY) 2004 LDRD projects support every one of the eight strategies described in the plan. In addition, LDRD efforts support the goals of Investing in America's Energy Future (six of the fourteen strategies), Resolving the Environmental Legacy (four of the eight strategies), and Meeting National Security Challenges (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD supports Office of Science strategic plans, including the 20 year Scientific Facilities Plan and the draft Office of Science Strategic Plan. The research also

  4. UNIVERSITY TURBINE SYSTEMS RESEARCH PROGRAM SUMMARY AND DIRECTORY

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence P. Golan; Richard A. Wenglarz

    2004-07-01

    The South Carolina Institute for Energy Studies (SCIES), administratively housed at Clemson University, has participated in the advancement of combustion turbine technology for over a decade. The University Turbine Systems Research Program, previously referred to as the Advanced Gas Turbine Systems Research (AGTSR) program, has been administered by SCIES for the U.S. DOE during the 1992-2003 timeframe. The structure of the program is based on a concept presented to the DOE by Clemson University. Under the supervision of the DOE National Energy Technology Laboratory (NETL), the UTSR consortium brings together the engineering departments at leading U.S. universities and U.S. combustion turbine developers to provide a solid base of knowledge for the future generations of land-based gas turbines. In the UTSR program, an Industrial Review Board (IRB) (Appendix C) of gas turbine companies and related organizations defines needed gas turbine research. SCIES prepares yearly requests for university proposals to address the research needs identified by the IRB organizations. IRB technical representatives evaluate the university proposals and review progress reports from the awarded university projects. To accelerate technology transfer technical workshops are held to provide opportunities for university, industry and government officials to share comments and improve quality and relevancy of the research. To provide educational growth at the Universities, in addition to sponsored research, the UTSR provides faculty and student fellowships. The basis for all activities--research, technology transfer, and education--is the DOE Turbine Program Plan and identification, through UTSR consortium group processes, technology needed to meet Program Goals that can be appropriately researched at Performing Member Universities.

  5. Cationized gelatin-HVJ envelope with sodium borocaptate improved the BNCT efficacy for liver tumors in vivo

    Directory of Open Access Journals (Sweden)

    Ono Koji

    2011-01-01

    Full Text Available Abstract Background Boron neutron capture therapy (BNCT is a cell-selective radiation therapy that uses the alpha particles and lithium nuclei produced by the boron neutron capture reaction. BNCT is a relatively safe tool for treating multiple or diffuse malignant tumors with little injury to normal tissue. The success or failure of BNCT depends upon the 10B compound accumulation within tumor cells and the proximity of the tumor cells to the body surface. To extend the therapeutic use of BNCT from surface tumors to visceral tumors will require 10B compounds that accumulate strongly in tumor cells without significant accumulation in normal cells, and an appropriate delivery method for deeper tissues. Hemagglutinating Virus of Japan Envelope (HVJ-E is used as a vehicle for gene delivery because of its high ability to fuse with cells. However, its strong hemagglutination activity makes HVJ-E unsuitable for systemic administration. In this study, we developed a novel vector for 10B (sodium borocaptate: BSH delivery using HVJ-E and cationized gelatin for treating multiple liver tumors with BNCT without severe adverse events. Methods We developed cationized gelatin conjugate HVJ-E combined with BSH (CG-HVJ-E-BSH, and evaluated its characteristics (toxicity, affinity for tumor cells, accumulation and retention in tumor cells, boron-carrying capacity to multiple liver tumors in vivo, and bio-distribution and effectiveness in BNCT therapy in a murine model of multiple liver tumors. Results CG-HVJ-E reduced hemagglutination activity by half and was significantly less toxic in mice than HVJ-E. Higher 10B concentrations in murine osteosarcoma cells (LM8G5 were achieved with CG-HVJ-E-BSH than with BSH. When administered into mice bearing multiple LM8G5 liver tumors, the tumor/normal liver ratios of CG-HVJ-E-BSH were significantly higher than those of BSH for the first 48 hours (p . In suppressing the spread of tumor cells in mice, BNCT treatment was as

  6. 77 FR 36983 - Processed Raspberry Promotion, Research and Information Program; Request for Extension and...

    Science.gov (United States)

    2012-06-20

    ...-0021] Processed Raspberry Promotion, Research and Information Program; Request for Extension and... approved information collection National Processed Raspberry Promotion, Research, and Information Program... . SUPPLEMENTARY INFORMATION: Title: National Processed Raspberry Promotion, Research, and Information Program....

  7. Monte Carlo based protocol for cell survival and tumour control probability in BNCT

    Science.gov (United States)

    Ye, Sung-Joon

    1999-02-01

    A mathematical model to calculate the theoretical cell survival probability (nominally, the cell survival fraction) is developed to evaluate preclinical treatment conditions for boron neutron capture therapy (BNCT). A treatment condition is characterized by the neutron beam spectra, single or bilateral exposure, and the choice of boron carrier drug (boronophenylalanine (BPA) or boron sulfhydryl hydride (BSH)). The cell survival probability defined from Poisson statistics is expressed with the cell-killing yield, the (n, ) reaction density, and the tolerable neutron fluence. The radiation transport calculation from the neutron source to tumours is carried out using Monte Carlo methods: (i) reactor-based BNCT facility modelling to yield the neutron beam library at an irradiation port; (ii) dosimetry to limit the neutron fluence below a tolerance dose (10.5 Gy-Eq); (iii) calculation of the (n, ) reaction density in tumours. A shallow surface tumour could be effectively treated by single exposure producing an average cell survival probability of - for probable ranges of the cell-killing yield for the two drugs, while a deep tumour will require bilateral exposure to achieve comparable cell kills at depth. With very pure epithermal beams eliminating thermal, low epithermal and fast neutrons, the cell survival can be decreased by factors of 2-10 compared with the unmodified neutron spectrum. A dominant effect of cell-killing yield on tumour cell survival demonstrates the importance of choice of boron carrier drug. However, these calculations do not indicate an unambiguous preference for one drug, due to the large overlap of tumour cell survival in the probable ranges of the cell-killing yield for the two drugs. The cell survival value averaged over a bulky tumour volume is used to predict the overall BNCT therapeutic efficacy, using a simple model of tumour control probability (TCP).

  8. Development of a tandem-electrostatic-quadrupole accelerator facility for BNCT.

    Science.gov (United States)

    Kreiner, A J; Thatar Vento, V; Levinas, P; Bergueiro, J; Di Paolo, H; Burlon, A A; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Minsky, D M; Estrada, L; Hazarabedian, A; Johann, F; Suarez Sandin, J C; Castell, W; Davidson, J; Davidson, M; Giboudot, Y; Repetto, M; Obligado, M; Nery, J P; Huck, H; Igarzabal, M; Fernandez Salares, A

    2009-07-01

    In this work we describe the present status of an ongoing project to develop a tandem-electrostatic-quadrupole (TESQ) accelerator facility for accelerator-based (AB) BNCT at the Atomic Energy Commission of Argentina in Buenos Aires. The project final goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the (7)Li(p,n)(7)Be reaction slightly beyond its resonance at 2.25 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the (7)Li(p,n)(7)Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. An electrostatic machine is the technologically simplest and cheapest solution for optimized AB-BNCT. The machine being designed and constructed is a folded TESQ with a high-voltage terminal at 1.2 MV intended to work in air. Such a machine is conceptually shown to be capable of transporting and accelerating a 30 mA proton beam to 2.4 MeV. The general geometric layout, its associated electrostatic fields, and the acceleration tube are simulated using a 3D finite element procedure. The design and construction of the ESQ modules is discussed and their electrostatic fields are investigated. Beam transport calculations through the accelerator are briefly mentioned. Likewise, work related to neutron production targets, strippers, beam shaping assembly and patient treatment room is briefly described.

  9. Preliminary Design of LEU MNSR for BNCT with Excellent Epithermal Neutron Flux Treatment Beam%高额超热中子束流治疗孔道低浓化BNCT堆初步设计方案

    Institute of Scientific and Technical Information of China (English)

    于涛; 钱金栋; 谢金森

    2012-01-01

    Based on the Miniature Neutron Source Reactor (MNSR) with high enrichment uranium (HEU) fuel and accordance with the requirements of BNCT, the 19.5% of enriched fuel UO2 fuel core for BNCT with epithermal neutron treatment beam was primary designed, the reactor core parameters such as epithermal neutron flux density,epithermal neutron flux unit of fast neutron dose rate,epithermal neutron flux unit photon dose rate of γ,epithermal neutron flux ratio of thermal neutron flux, neutron spectrum were calculated and analyzed. The results show that the design program was an excellent epithermal neutron treatment beam.%根据硼中子俘获治疗( BNCT)中子源的要求,在高浓铀为燃料的微型反应堆(MNSR)的基础上,以富集度19.5%的UO2为燃料,将其堆芯低浓化并且添加水平超热中子束流治疗孔道,开展超热中子束流BNCT堆堆芯低浓化初步设计.计算BNCT堆的超热中子注量率、单位超热中子注量的快中子剂量率、单位超热中子注量的γ光子剂量率、超热中子注量与热中子的注量之比、中子束流能谱等关键参数.结果表明,该设计可以得到优良的超热中子束流.

  10. The SUPER Program: A Research-based Undergraduate Experience

    Science.gov (United States)

    Ernakovich, J. G.; Boone, R. B.; Boot, C. M.; Denef, K.; Lavallee, J. M.; Moore, J. C.; Wallenstein, M. D.

    2014-12-01

    Producing undergraduates capable of broad, independent thinking is one of the grand challenges in science education. Experience-based learning, specifically hands-on research, is one mechanism for increasing students' ability to think critically. With this in mind, we created a two-semester long research program called SUPER (Skills for Undergraduate Participation in Ecological Research) aimed at teaching students to think like scientists and enhancing the student research experience through instruction and active-learning about the scientific method. Our aim was for students to gain knowledge, skills, and experience, and to conduct their own research. In the first semester, we hosted active-learning workshops on "Forming Hypotheses", "Experimental Design", "Collecting and Managing Data", "Analysis of Data", "Communicating to a Scientific Audience", "Reading Literature Effectively", and "Ethical Approaches". Each lesson was taught by different scientists from one of many ecological disciplines so that students were exposed to the variation in approach that scientists have. In the second semester, students paired with a scientific mentor and began doing research. To ensure the continued growth of the undergraduate researcher, we continued the active-learning workshops and the students attended meetings with their mentors. Thus, the students gained technical and cognitive skills in parallel, enabling them to understand both "the how" and "the why" of what they were doing in their research. The program culminated with a research poster session presented by the students. The interest in the program has grown beyond our expectations, and we have now run the program successfully for two years. Many of the students have gone on to campus research jobs, internships and graduate school, and have attributed part of their success in obtaining their positions to their experience with the SUPER program. Although common in other sciences, undergraduate research experiences are

  11. From biological to program efficacy: promoting dialogue among the research, policy, and program communities.

    Science.gov (United States)

    Habicht, Jean-Pierre; Pelto, Gretel H

    2014-01-01

    The biological efficacy of nutritional supplements to complement usual diets in poor populations is well established. This knowledge rests on decades of methodologic research development and, more recently, on codification of methods to compile and interpret results across studies. The challenge now is to develop implementation (delivery) science knowledge and achieve a similar consensus on efficacy criteria for the delivery of these nutrients by public health and other organizations. This requires analysis of the major policy instruments for delivery and well-designed program delivery studies that examine the flow of a nutrient through a program impact pathway. This article discusses the differences between biological and program efficacy, and why elucidating the fidelity of delivery along the program impact pathways is essential for implementing a program efficacy trial and for assessing its internal and external validity. Research on program efficacy is expanding, but there is a lack of adequate frameworks to facilitate the process of harmonizing concepts and vocabulary, which is essential for communication among scientists, policy planners, and program implementers. There is an urgent need to elaborate these frameworks at national and program levels not only for program efficacy studies but also for the broader research agenda to support and improve the science of delivering adequate nutrition to those who need it most.

  12. Atmospheric Sciences Program summaries of research in FY 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    This document describes the activities and products of the Atmospheric Science Program of the Environmental Sciences Division, Office of Health and Environmental Research, Office of Energy Research, in FY 1993. Each description contains the project`s title; three-year funding history; the contract period over which the funding applies; the name(s) of the principal investigator(s); the institution(s) conducting the projects; and the project`s objectives, products, approach, and results to date. Project descriptions are categorized within the report according to program areas: atmospheric chemistry, atmospheric dynamics, and support operations. Within these categories, the descriptions are ordered alphabetically by principal investigator. Each program area is preceded by a brief text that defines the program area, states its goals and objectives, lists principal research questions, and identifies program managers. Appendixes provide the addresses and telephone numbers of the principal investigators and define the acronyms used. This document has been indexed to aid the reader in locating research topics, participants, and research institutions in the text and the project descriptions. Comprehensive subject, principal investigator, and institution indexes are provided at the end of the text for this purpose. The comprehensive subject index includes keywords from the introduction and chapter texts in addition to those from the project descriptions.

  13. Laboratory Directed Research and Development Program FY2011

    Energy Technology Data Exchange (ETDEWEB)

    none, none

    2012-04-27

    Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Themes that are codified in DOE's 2006 Strategic Plan (DOE/CF-0010), with a primary focus on Scientific Discovery and Innovation. For that strategic theme, the Fiscal Year (FY) 2011 LDRD projects support each one of the three goals through multiple strategies described in the plan. In addition, LDRD efforts support the four goals of Energy Security, the two goals of Environmental Responsibility, and Nuclear Security (unclassified fundamental research that supports stockpile safety and nonproliferation programs). Going forward in FY 2012, the LDRD program also supports the Goals codified in the new DOE Strategic Plan of May, 2011. The LDRD program also supports Office of Science strategic plans, including the 20-year Scientific Facilities Plan and the Office of Science Strategic Plan. The research also supports the strategic directions periodically under consideration and review by the Office of Science Program Offices, such as LDRD projects germane to new research facility concepts and new fundamental science directions. Brief summares of projects and accomplishments for the period for each division are included.

  14. Filter/moderator system for a BNCT beam of epithermal neutrons at nuclear reactor MARIA

    Science.gov (United States)

    Tyminska, Katarzyna

    2009-01-01

    Boron Neutron Capture Therapy is a very promising form of cancer therapy, consisting in irradiating a stable isotope of boron (10B) concentrated in tumor cells with a low energy neutron beam. This technique makes it possible to destroy tumor cells, leaving healthy tissues practically unaffected. In order to carry out the therapy in the proper way, the proper range of the neutron beam energy has to be chosen. In this paper we present a filter/moderator system modeled with MCNP code in order to obtain an epithermal neutron beam for BNCT post at MARIA reactor in Swierk.

  15. Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Shirakawa, Makoto [Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba (Japan)], E-mail: m0720347@md.tsukuba.ac.jp; Yamamto, Tetsuya; Nakai, Kei [Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba (Japan); Aburai, Kenichi [Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (Japan); Kawatobi, Sho [Faculty of Pharmaceutical Sciences, Toho University (Japan); Tsurubuchi, Takao; Yamamoto, Yohei [Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba (Japan); Yokoyama, Yuusaku; Okuno, Hiroaki [Faculty of Pharmaceutical Sciences, Toho University (Japan); Matsumura, Akira [Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba (Japan)

    2009-07-15

    We aimed at securing sufficient concentrations of {sup 10}B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron component liposome. It consisted of three different kinds of amino acid derivatives and two fatty acids, and could react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes.

  16. The optimization study of Bonner sphere in the epi-thermal neutron irradiation field for BNCT.

    Science.gov (United States)

    Ueda, H; Tanaka, H; Maruhashi, A; Ono, K; Sakurai, Y

    2011-12-01

    The optimization study on the Bonner sphere in the epi-thermal neutron irradiation field for BNCT was done for the moderator material, moderator size, and activation foils as a neutron detector in the sphere. The saturated activity for the activation foil was obtained from the calculated response, and the effective energy range for each Bonner sphere was determined from the saturated activity. We can see that boric acid solution moderator is suitable for the spectrum measurement of a epi-thermal neutron irradiation field.

  17. A plastic scintillator-based 2D thermal neutron mapping system for use in BNCT studies.

    Science.gov (United States)

    Ghal-Eh, N; Green, S

    2016-06-01

    In this study, a scintillator-based measurement instrument is proposed which is capable of measuring a two-dimensional map of thermal neutrons within a phantom based on the detection of 2.22MeV gamma rays generated via nth+H→D+γ reaction. The proposed instrument locates around a small rectangular water phantom (14cm×15cm×20cm) used in Birmingham BNCT facility. The whole system has been simulated using MCNPX 2.6. The results confirm that the thermal flux peaks somewhere between 2cm and 4cm distance from the system entrance which is in agreement with previous studies.

  18. Applied Science Division annual report, Environmental Research Program FY 1983

    Energy Technology Data Exchange (ETDEWEB)

    Cairns, E.J.; Novakov, T.

    1984-05-01

    The primary concern of the Environmental Research Program is the understanding of pollutant formation, transport, and transformation and the impacts of pollutants on the environment. These impacts include global, regional, and local effects on the atmosphere and hydrosphere, and on certain aspects of human health. This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. During FY 1983, research concentrated on atmospheric physics and chemistry, applied physics and laser spectroscopy, combustion theory and phenomena, environmental effects of oil shale processing, freshwater ecology and acid precipitation, trace element analysis for the investigation of present and historical environmental impacts, and a continuing survey of instrumentation for environmental monitoring.

  19. The collaborative program of research in engineering science

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-01

    MIT and Idaho National Engineering Laboratory are continuing the program of collaborative research on energy-related engineering. The program involves research in the following areas: (1) mathematical modeling of thermal plasma systems, (2) high-temperature gas-particle reactions, (3) metal transfer in gas-metal arc welding, (4) multivariate control of gas-metal arc welding, (5) fundamentals of elastic-plastic fracture, (6) comminution of energy materials, and (7) synthesis and optimization of integrated chemical processes. A key objective of this collaborative program is to serve as a prototype for other university/laboratory collaborative programs. Another important goal is to enhance the transfer of new technology to the industrial sector.

  20. Danish integrated antimicrobial in resistance monitoring and research program

    DEFF Research Database (Denmark)

    Hammerum, Anette Marie; Heuer, Ole Eske; Emborg, Hanne-Dorthe

    2007-01-01

    Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a s...... activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries....... a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research......Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish...

  1. Evaluating the High School Lunar Research Projects Program

    Science.gov (United States)

    Shaner, A. J.; Shupla, C.; Shipp, S.; Allen, J.; Kring, D. A.

    2013-01-01

    The Center for Lunar Science and Exploration (CLSE), a collaboration between the Lunar and Planetary Institute and NASA s Johnson Space Center, is one of seven member teams of the NASA Lunar Science Institute (NLSI). In addition to research and exploration activities, the CLSE team is deeply invested in education and outreach. In support of NASA s and NLSI s objective to train the next generation of scientists, CLSE s High School Lunar Research Projects program is a conduit through which high school students can actively participate in lunar science and learn about pathways into scientific careers. The objectives of the program are to enhance 1) student views of the nature of science; 2) student attitudes toward science and science careers; and 3) student knowledge of lunar science. In its first three years, approximately 168 students and 28 teachers from across the United States have participated in the program. Before beginning their research, students undertake Moon 101, a guided-inquiry activity designed to familiarize them with lunar science and exploration. Following Moon 101, and guided by a lunar scientist mentor, teams choose a research topic, ask their own research question, and design their own research approach to direct their investigation. At the conclusion of their research, teams present their results to a panel of lunar scientists. This panel selects four posters to be presented at the annual Lunar Science Forum held at NASA Ames. The top scoring team travels to the forum to present their research in person.

  2. US Army Research Laboratory Directed Energy Internship Program 2014

    Science.gov (United States)

    2015-11-01

    describing the program and our team’s research topics was posted on ARL’s Internet site and linked from the DEPS site. We also published a free ad in...in the importance of training the future Department of Defense workforce and believe that the Directed Energy Visiting Scholars program provides...pipelining of multi-part designs. Finally, one of the last things that could be accomplished is making the schematic to CAD process easier. This is

  3. Research on the Business English training model within MBA program

    OpenAIRE

    Natalia Yankovskaya; Olga Neklyudova

    2015-01-01

    The paper presents a brief summary of the research on the Business English training model within MBA program students. This study is devoted to the problem of developing a professional foreign language communicative competency of MBA program participants. A particular feature of additional MBA qualification is its international status which presupposes that its graduates (mid-level and top managers) should realize their professional tasks in a foreign language. The analysis of literary ...

  4. NASA/GE Highly-Loaded Turbine Research Program

    Science.gov (United States)

    Giel, Paul W.

    2008-01-01

    An overview of the NASA/GE Highly-Loaded Turbine Research Program at the NASA Glenn Research Center is presented. The program is sponsored by the Subsonic Fixed Wing Project of the Fundamental Aeronautics Program. The goals of the turbine research program are presented along with their relationship to the higher-level program goals. Two turbine research programs are described; the highly-loaded, single-stage high pressure turbine (HPT) and the highly loaded low pressure turbine (LPT). The HPT program is centered on an extremely high pressure ratio single-stage turbine with an engine stage pressure ratio of 5.5. It was designed with a 33% increase in stage loading. It has shown performance levels 2 points better than current engines operating at the higher work level. Some advantages of the turbine include reduced weight and parts count. Optimization of the blade shape to reduce shock losses is described. The LPT program utilizes a four-stage low pressure turbine with an integral first stage vane/transition duct strut; counterrotation; low-solidity blading; fully optimized flowpath including vanes, blades, and endwalls; and a fluidically controlled turbine vane frame/exit guide vane. The implementation of the LPT into GE s and NASA s test facilities is described. A description of NASA s Single Spool Turbine Facility that is currently under renovation is given. The new, upgraded facility is compared to its predecessor. Renovation design requirements are outlined. Facility limits on pressures, temperatures, flow rates, rotational speeds, and power absorption are described. The current renovation status is given.

  5. From Mice to Men: research models of developmental programming

    OpenAIRE

    2013-01-01

    Developmental programming can be defined as a response to a specific challenge to the mammalian organism during a critical developmental time window that alters the trajectory of development with persistent effects on offspring phenotype and predisposition to future illness. We focus on the need for studies in relevant, well-characterized animal models in the context of recent research discoveries on the challenges, mechanisms and outcomes of developmental programming. We discuss commonalitie...

  6. The collaborative program of research in engineering sciences

    Energy Technology Data Exchange (ETDEWEB)

    White, D.C.

    1989-08-01

    Research programs in the following areas are briefly described: High-Temperature Gas-Particle Reactions; Mathematical Modelling of Plasma Systems; Metal Transfer in Gas Metal-Arc Welding; Multivariable Control of Gas Metal-Arc Welding; Synthesis of Heat and Work Integration Systems for Chemical Process Plants; Parity Simulation of Dynamic Processes; Fundamentals of Elastic-Plastic Fracture: Three-Dimensional and Mechanistic Modelling; and Comminution of Energy Materials. Publications from each program are listed.

  7. Research Donor Program Needs Your Help to Advance Cancer and AIDS Research | Poster

    Science.gov (United States)

    NCI at Frederick employees have a unique opportunity to contribute directly to cancer and AIDS research by donating blood, saliva, and other samples through the Research Donor Program (RDP). Donors are compensated for their time, which is typically between 10 and 30 minutes. The RDP, which is administered by Occupational Health Services (OHS), Leidos Biomedical Research, provides samples from healthy donors for use in in vitro research conducted at NCI at Frederick and Fort Detrick. Samples are provided anonymously to researchers.

  8. Laboratory Directed Research and Development Program FY 2006

    Energy Technology Data Exchange (ETDEWEB)

    Hansen (Ed.), Todd

    2007-03-08

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness.

  9. Integrating Research and Education in NSF's Office of Polar Programs

    Science.gov (United States)

    Wharton, R. A.; Crain, R. D.

    2003-12-01

    The National Science Foundation invests in activities that integrate research and education, and that develop reward systems to support teaching, mentoring and outreach. Effective integration of research and education at all levels can infuse learning with the excitement of discovery. It can also ensure that the findings and methods of research are quickly and effectively communicated in a broader context and to a larger audience. This strategy is vital to the accomplishment of NSF's strategic goals of ensuring a world-class science and engineering workforce, new knowledge across the frontiers of science and engineering, and the tools to get the job done efficiently and effectively. The NSF's Office of Polar Programs sponsors educational projects at all levels of learning, making full use of the variety of disciplinary and interdisciplinary studies in the polar regions to attract and invigorate students. An array of efforts from the Arctic and Antarctic scientific communities link research activities with education. There has been an advance from the beneficial but isolated impacts of individual researcher visits to K-12 classrooms to large-scale developments, such as field research experiences for teachers and undergraduate students, online sharing of polar field experiences with rural classrooms, the institution of interdisciplinary graduate research programs through NSF initiatives, and opportunities for minority and underrepresented groups in polar sciences. The NSF's criterion for evaluating proposals based upon the broader impacts of the research activity has strengthened efforts to link research and education, resulting in partnerships and innovations that infuse research into education from kindergarten through postdoctoral studies and reaching out to the general public. In addition, the Office of Polar Programs partners with other directorates at NSF to broaden OPP's efforts and benefit from resources and experience in the Education and Human Resources

  10. Disaster Research Team Building: A Case Study of a Web-based Disaster Research Training Program.

    Science.gov (United States)

    Beaton, Randal D; Johnson, L Clark; Maida, Carl A; Houston, J Brian; Pfefferbaum, Betty

    2012-11-19

    This case study describes the process and outcomes of the Northwest Center for Public Health Practice Child and Family Disaster Research Training (UWDRT) Program housed at the University of Washington, which used web-based distance learning technology. The purposes of this program were to provide training and to establish a regional cadre of researchers and clinicians; to increase disaster mental health research capacity and collaboration; and to improve the scientific rigor of research investigations of disaster mental health in children and families. Despite a number of obstacles encountered in development and implementation, outcomes of this program included increased team member awareness and knowledge of child and family disaster mental health issues; improved disaster and public health instruction and training independent of the UWDRT program; informed local and state disaster response preparedness and response; and contributions to the child and family disaster mental health research literature.

  11. Langley Research Center Metrology Program status for fiscal year 1987

    Science.gov (United States)

    Kern, Frederick A.

    1988-01-01

    The status of the Langley Research Center's metrology program for fiscal year 1987 is presented. The NASA Metrology Information System, which was operational for the entire year, provided the majority of performance data describing work analysis, turnaround time, out-of-tolerance instrument data, and other instrument service data. Calibration system development, equipment replacing and updating, status of last year's planned objectives, and Reference Standard certification requirements are described. The status of the LaRC voltage and resistance measurement assurance program and the agency-wide resistance program are reviewed. Progress on fiscal year 1987 objectives is discussed and fiscal year 1988 objectives are stated.

  12. Laboratory directed research and development program, FY 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab) Laboratory Directed Research and Development Program FY 1996 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Berkeley Lab LDRD program is a critical tool for directing the Laboratory`s forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for Berkeley Lab scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances the Laboratory`s core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. Areas eligible for support include: (1) Work in forefront areas of science and technology that enrich Laboratory research and development capability; (2) Advanced study of new hypotheses, new experiments, and innovative approaches to develop new concepts or knowledge; (3) Experiments directed toward proof of principle for initial hypothesis testing or verification; and (4) Conception and preliminary technical analysis to explore possible instrumentation, experimental facilities, or new devices.

  13. Research opportunities in photochemical sciences for the DOE Hydrogen Program

    Energy Technology Data Exchange (ETDEWEB)

    Padro, C.E.G. [National Renewable Energy Laboratory, Golden, CO (United States)

    1996-09-01

    For several decades, interest in hydrogen has ebbed and flowed. With the OPEC oil embargo of the 1970`s and the promise of inexpensive nuclear power, hydrogen research focused on fuel applications. The economics and the realities of nuclear power shifted the emphasis to hydrogen as an energy carrier. Environmental benefits took center stage as scientists and politicians agreed on the potential threat of carbon dioxide emissions to global climate change. The U.S. Department of Energy (DOE) Office of Utility Technologies manages the National Hydrogen Program. In this role, the DOE provides national leadership and acts as a catalyst through partnerships with industry. These partnerships are needed to assist in the transition of sustainable hydrogen systems from a government-supported research and development phase to commercial successes in the marketplace. The outcome of the Program is expected to be the orderly phase-out of fossil fuels as a result of market-driven technology advances, with a least-cost, environmentally benign energy delivery system. The program seeks to maintain its balance of high-risk, long-term research in renewable based technologies that address the environmental benefits, with nearer-term, fossil based technologies that address infrastructure and market issues. National laboratories, universities, and industry are encouraged to participate, cooperate, and collaborate in the program. The U.S. Hydrogen Program is poised to overcome the technical and economic challenges that currently limit the impact of hydrogen on our energy picture, through cooperative research, development, and demonstrations.

  14. Research Reports: 1997 NASA/ASEE Summer Faculty Fellowship Program

    Science.gov (United States)

    Karr, G. R. (Editor); Dowdy, J. (Editor); Freeman, L. M. (Editor)

    1998-01-01

    For the 33rd consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama in Huntsville and MSFC during the period June 2, 1997 through August 8, 1997. Operated under the auspices of the American Society for Engineering Education, the MSFC program was sponsored by the Higher Education Branch, Education Division, NASA Headquarters, Washington, D.C. The basic objectives of the program, which are in the 34th year of operation nationally, are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA centers. The Faculty Fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 1997. The University of Alabama in Huntsville presents the Co-Directors' report on the administrative operations of the program. Further information can be obtained by contacting any of the editors.

  15. Research Reports: 1995 NASA/ASEE Summer Faculty Fellowship Program

    Science.gov (United States)

    Karr, G. R. (Editor); Chappell, C. R. (Editor); Six, F. (Editor); Freeman, L. M. (Editor)

    1996-01-01

    For the 31st consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama in Huntsville and MSFC during the period 15 May 1995 - 4 Aug. 1995. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA centers, was sponsored by the Higher Education Branch, Education Division, NASA Headquarters, Washington, D.C. The basic objectives of the programs, which are in the 32nd year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA centers. The Faculty Fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 1995. The University of Alabama in Huntsville presents the Co-Directors' report on the administrative operations of the program. Further information can be obtained by contacting any of the editors.

  16. Research Reports: 1996 NASA/ASEE Summer Faculty Fellowship Program

    Science.gov (United States)

    Freeman, M. (Editor); Chappell, C. R. (Editor); Six, F. (Editor); Karr, G. R. (Editor)

    1996-01-01

    For the 32nd consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama and MSFC during the period May 28, 1996 through August 2, 1996. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA centers, was sponsored by the Higher Education Branch, Education Division, NASA Headquarters, Washington, D.C. The basic objectives of the programs, which are in the 33rd year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA centers. The Faculty Fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 1996. The University of Alabama presents the Co-Directors' report on the administrative operations of the program. Further information can be obtained by contacting any of the editors.

  17. Animal Models and Bone Histomorphometry: Translational Research for the Human Research Program

    Science.gov (United States)

    Sibonga, Jean D.

    2010-01-01

    This slide presentation reviews the use of animal models to research and inform bone morphology, in particular relating to human research in bone loss as a result of low gravity environments. Reasons for use of animal models as tools for human research programs include: time-efficient, cost-effective, invasive measures, and predictability as some model are predictive for drug effects.

  18. Laboratory Directed Research and Development Program Activities for FY 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Looney,J.P.; Fox, K.

    2009-04-01

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that maintains a primary mission focus the physical sciences, energy sciences, and life sciences, with additional expertise in environmental sciences, energy technologies, and national security. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal year 2008 budget was $531.6 million. There are about 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Developlnent at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. Accordingly, this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2008. BNL expended $12 million during Fiscal Year 2008 in support of 69 projects. The program has two categories, the annual Open Call LDRDs and Strategic LDRDs, which combine to meet the overall objectives of the LDRD Program. Proposals are solicited annually for review and approval concurrent with the next fiscal year, October 1. For the open call for proposals, an LDRD Selection Committee, comprised of the Associate Laboratory Directors (ALDs) for the Scientific Directorates, an equal number of scientists recommended by the Brookhaven Council, plus the Assistant Laboratory Director for Policy and Strategic Planning, review the proposals submitted in response to the solicitation. The Open Can LDRD category emphasizes innovative research concepts

  19. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, James R.

    2002-04-30

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  20. INEEL Advanced Radiotherapy Research Program Annual Report 2001

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, James Robert

    2002-04-01

    This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

  1. Librarian-researcher cooperation with a liaison program

    Energy Technology Data Exchange (ETDEWEB)

    Ekkebus, A.E.

    1985-01-01

    During the four years of the liaison program, changes that have resulted include an increase in levels of library activity especially literature searching (a 60% increase in three years), a willingness by researchers to make their information needs known, and the development of a responsive collection. Surveys of recipients of the literature searches have indicated high satisfaction of the search results. The liaison program encourages communication between the reference librarian and researcher and better enables the library to attain its objective of interpreting and meeting the information needs of its users.

  2. The 2004 NASA Faculty Fellowship Program Research Reports

    Science.gov (United States)

    Pruitt, J. R.; Karr, G.; Freeman, L. M.; Hassan, R.; Day, J. B. (Compiler)

    2005-01-01

    This is the administrative report for the 2004 NASA Faculty Fellowship Program (NFFP) held at the George C. Marshall Space Flight Center (MSFC) for the 40th consecutive year. The NFFP offers science and engineering faculty at U.S. colleges and universities hands-on exposure to NASA s research challenges through summer research residencies and extended research opportunities at participating NASA research Centers. During this program, fellows work closely with NASA colleagues on research challenges important to NASA's strategic enterprises that are of mutual interest to the fellow and the Center. The nominal starting and .nishing dates for the 10-week program were June 1 through August 6, 2004. The program was sponsored by NASA Headquarters, Washington, DC, and operated under contract by The University of Alabama, The University of Alabama in Huntsville, and Alabama A&M University. In addition, promotion and applications are managed by the American Society for Engineering Education (ASEE) and assessment is completed by Universities Space Research Association (USRA). The primary objectives of the NFFP are to: Increase the quality and quantity of research collaborations between NASA and the academic community that contribute to the Agency s space aeronautics and space science mission. Engage faculty from colleges, universities, and community colleges in current NASA research and development. Foster a greater public awareness of NASA science and technology, and therefore facilitate academic and workforce literacy in these areas. Strengthen faculty capabilities to enhance the STEM workforce, advance competition, and infuse mission-related research and technology content into classroom teaching. Increase participation of underrepresented and underserved faculty and institutions in NASA science and technology.

  3. NASA space life sciences research and education support program

    Science.gov (United States)

    Jones, Terri K.

    1995-01-01

    USRA's Division of Space Life Sciences (DSLS) was established in 1983 as the Division of Space Biomedicine to facilitate participation of the university community in biomedical research programs at the NASA Johnson Space Center (JSC). The DSLS is currently housed in the Center for Advanced Space Studies (CASS), sharing quarters with the Division of Educational Programs and the Lunar and Planetary Institute. The DSLS provides visiting scientists for the Johnson Space Center; organizes conferences, workshops, meetings, and seminars; and, through subcontracts with outside institutions, supports NASA-related research at more than 25 such entities. The DSLS has considerable experience providing visiting scientists, experts, and consultants to work in concert with NASA Life Sciences researchers to define research missions and goals and to perform a wide variety of research administration and program management tasks. The basic objectives of this contract have been to stimulate, encourage, and assist research and education in the NASA life sciences. Scientists and experts from a number of academic and research institutions in this country and abroad have been recruited to support NASA's need to find a solution to human physiological problems associated with living and working in space and on extraterrestrial bodies in the solar system.

  4. Program evaluation as community-engaged research: Challenges and solutions

    Directory of Open Access Journals (Sweden)

    Richard Reed

    2015-09-01

    Full Text Available This article reflects on the challenges and opportunities that have arisen in the course of evaluative research into the impact of a number of schools’ engagement programs at Macquarie University, Sydney. It maps out how the research has been conceived and then operationalised as an engaged model of research that includes consultations and collaborations at multiple stages of the research, from conception to dissemination. The article then considers a number of the challenges that have arisen and, in the context of current understanding of best practice in community-engaged research, discusses some of the strategies that were deployed in response to these challenges. By critically examining the limitations of these responses, the article ultimately reinforces the argument that the complexities of engaged research mean that the perfectly engaged research project remains, in most cases, an impossible myth. Instead, community-engaged research should be seen as an approach to research, or an attitude to embed into practice, which ultimately requires embracing a ‘can always do better’ approach to conducting research and a commitment to collaboration and democratic practice that goes beyond the immediate context of the research project. Keywords: Evaluative research, evaluation, community-engaged research, collaboration

  5. Employment of MCNP in the study of TLDS 600 and 700 seeking the implementation of radiation beam characterization of BNCT facility at IEA-R1; Emprego do MCNP no estudo dos TLDS 600 e 700 visando a implementacao da caracterizacao do feixe de irradiacao da instalacao de BNCT do IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Cavalieri, Tassio Antonio

    2013-07-01

    Boron Neutron Capture Therapy, BNCT, is a bimodal radiotherapy procedure for cancer treatment. Its useful energy comes from a nuclear reaction driven by impinging thermal neutron upon Boron 10 atoms. A BNCT research facility has been constructed in IPEN at the IEA-R1 reactor, to develop studies in this area. One of its prime experimental parameter is the beam dosimetry which is nowadays made by using activation foils, for neutron measurements, and TLD 400, for gamma dosimetry. For mixed field dosimetry, the International Commission on Radiation Units and Measurements, ICRU, recommends the use of pair of detectors with distinct responses to the field components. The TLD 600/ TLD 700 pair meets this criteria, as the amount of {sup 6}Li, a nuclide with high thermal neutron cross section, greatly differs in their composition. This work presents a series of experiments and simulations performed in order to implement the mixed field dosimetry based on the use of TLD 600/TLD 700 pair. It also intended to compare this mixed field dosimetric methodology to the one so far used by the BNCT research group of IPEN. The response of all TLDs were studied under irradiations in different irradiation fields and simulations, underwent by MCNP, were run in order to evaluate the dose contribution from each field component. Series of repeated irradiations under pure gamma field and mixed field neutron/gamma field showed differences in the TLD individual responses which led to the adoption of a Normalization Factor. It has allowed to overcome TLD selection. TLD responses due to different field components and spectra were studied. It has shown to be possible to evaluate the relative gamma/neutron fluxes from the relative responses observed in the two Regions of Interest, ROIs, from TLD 600 and TLD 700. It has also been possible to observe the TLD 700 response to neutron, which leads to a gamma dose overestimation when one follows the ICRU recommended mixed field dosimetric procedure. Dose

  6. Laboratory Directed Research and Development Program FY 2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    editor, Todd C Hansen

    2009-02-23

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Themes that are codified in DOE's 2006 Strategic Plan (DOE/CF-0010), with a primary focus on Scientific Discovery and Innovation. For that strategic theme, the Fiscal Year (FY) 2008 LDRD projects support each one of the three goals through multiple strategies described in the plan. In addition, LDRD efforts support the four goals of Energy Security, the two goals of Environmental Responsibility, and Nuclear Security (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD program supports Office of Science strategic plans, including the 20-year Scientific Facilities Plan and the Office of Science Strategic Plan. The research also supports the strategic directions periodically under

  7. [Environmental Hazards Assessment Program annual report, June 1992--June 1993]. Summer undergraduate research program: Environmental studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J. [ed.

    1993-12-01

    The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. Ten students from throughout the midwestern and eastern areas of the country were accepted into the program. These students selected projects in the areas of marine sciences, biostatistics and epidemiology, and toxicology. The research experience for all these students and their mentors was very positive. The seminars were well attended and the students showed their interest in the presentations and environmental sciences as a whole by presenting the speakers with thoughtful and intuitive questions. This report contains the research project written presentations prepared by the student interns.

  8. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT PROGRAM ASSESSMENT FOR FY 2006.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2006-01-01

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's total annual budget has averaged about $460 million. There are about 2,500 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, ''Laboratory Directed Research and Development,'' April 19,2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy National Nuclear Security Administration Laboratories dated June 13,2006. The goals and' objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new

  9. Laboratory Directed Research and Development Program Assessment for FY 2007

    Energy Technology Data Exchange (ETDEWEB)

    Newman,L.; Fox, K.J.

    2007-12-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal Year 2007 spending was $515 million. There are approximately 2,600 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development', April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology ideas, which

  10. 77 FR 33729 - Disability and Rehabilitation Research Projects and Centers Program-National Data and Statistical...

    Science.gov (United States)

    2012-06-07

    ... Disability and Rehabilitation Research Projects and Centers Program--National Data and Statistical Center for... on Disability and Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research Project (DRRP)-- National Data and...

  11. Assess program: Interactive data management systems for airborne research

    Science.gov (United States)

    Munoz, R. M.; Reller, J. O., Jr.

    1974-01-01

    Two data systems were developed for use in airborne research. Both have distributed intelligence and are programmed for interactive support among computers and with human operators. The C-141 system (ADAMS) performs flight planning and telescope control functions in addition to its primary role of data acquisition; the CV-990 system (ADDAS) performs data management functions in support of many research experiments operating concurrently. Each system is arranged for maximum reliability in the first priority function, precision data acquisition.

  12. CAS spearheads R&D program for research facilities

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ China's capacity for indigenous S&T innovation is believed to have been hampered by its lack of home- grown research facilities. To address the problem, a pilot program for the research and development of major S&T facilities has been launched at CAS. The kick-off meeting was held on 28 March in the CAS Technical Institute of Physics and Chemistry in Beijing.

  13. Summer Internship Program at the Monterey Bay Aquarium Research Institute

    Science.gov (United States)

    Matsumoto, G. I.

    2009-12-01

    The Monterey Bay Aquarium Research Institute formally started the Internship Program in 1997. The program is open to undergraduate and graduate students and educators. The purpose of the Program is to provide an opportunity for talented students and teachers to come to MBARI for a certain period of time and to work on a research project under MBARI staff supervision. The interns are selected following a rigorous application procedure, merit review and, in some cases, an interview process. They are from around the world and represent a variety of different backgrounds, experience, and education. They all share a common desire to learn more about the marine environment and to work with MBARI staff. The mission of the Monterey Bay Aquarium Research Institute is to serve as a world center for advanced research and education in ocean science and technology. MBARI strives to achieve this mission through the development of better instruments, systems, and methods for scientific research in the deep ocean. MBARI emphasizes peer relationships between engineers and scientists as a basic principle of its operation. Teams at MBARI use cutting-edge technology to develop equipment, software, and research methods to meet the specific needs of deep-sea research. The focus of the MBARI internship is on the intern’s professional development—learning research techniques and improving communication and collaboration skills. Each intern has an MBARI mentor who will supervise a specific project. Interns will also serve as peer-mentors to other interns. This presentation will provide a brief overview of the history of the program as well as lessons learned. 2009 MBARI SUMMER INTERNS WITH PRESIDENT AND CEO MARCIA MCNUTT

  14. Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, T., E-mail: fujitaku@hp.pref.hyogo.jp [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Andoh, T. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan); Sudo, T. [Section of Translational Research, Hyogo Cancer Center, Akashi 673-0021 (Japan); Fujita, I.; Imabori, M. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Moritake, H. [Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692 (Japan); Sugimoto, T. [Department of Pediatrics, Saiseikai Shigaken Hospital, Ritto 520-3046 (Japan); Sakuma, Y. [Department of Pathology, Hyogo Cancer Center, Akashi 673-0021 (Japan); Takeuchi, T. [Department of Pathology, Kochi Medical School, Nangoku 783-8505 (Japan); Sonobe, H. [Department of Pathology, Chugoku Central Hospital, Fukuyama 720-0001 (Japan); Epstein, Alan L. [Department of Pathology, Keck School of Medicine,University of Southern California, Los Angeles,CA 90033 (United States); Akisue, T. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Kirihata, M. [Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599-8531 (Japan); Kurosaka, M. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fukumori, Y.; Ichikawa, H. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan)

    2011-12-15

    Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also produces melanin; therefore, the uptake of BPA is the key to the application of BNCT to CCS. We describe, for the first time, the high accumulation of boron in CCS and the CCS tumor-bearing animal model generated for BNCT studies.

  15. Development and calculation of an energy dependent normal brain tissue neutron RBE for evaluating neutron fields for BNCT.

    Science.gov (United States)

    Woollard, J E; Blue, T E; Gupta, N; Gahbauer, R A

    2001-06-01

    In Boron Neutron Capture Therapy (BNCT) of malignant brain tumors, the energy dependence of a clinically relevant Relative Biological Effectiveness (RBE) for epithermal neutrons, RBE(En), is important in neutron field design. In the first half of this paper, we present the development of an expression for the energy dependent normal-tissue RBE, RBE(En). We then calculate a reasonable estimate for RBE(En) for adult brain tissue. In the second half of the paper, two separate RBE expressions are developed, one for the RBE of the neutrons that interact in tissue via the 14N(n,p)14C reaction, denoted RBE(N), and one for the RBE of the neutrons which interact in tissue via the 1H(n,n')1H reaction, denoted RBE(H). The absorbed-dose-averaged values of these expressions are calculated for the neutron flux spectrum in phantom for the Brookhaven Medical Research Reactor (BMRR) epithermal neutron beam. The calculated values, [RBE(norm)N] = 3.4 and [RBE(norm)H] = 3.2, are within 6% of being equal, and support the use of equal values for RBEN and RBE(H) by researchers at Brookhaven National Laboratory (BNL). Finally, values of [RBE(norm)N] and [RBE(norm)H], along with the absorbed-dose-averaged RBE for brain, [RBE(norm)b], were calculated as a function of depth along the centerline of an ellipsoidal head phantom using flux spectra calculated for our Accelerator-Based Neutron Source (ABNS). These values remained essentially constant with depth, supporting the use of constant values for RBE, as is done at BNL.

  16. Feasibility of the Utilization of BNCT in the Fast Neutron Therapy Beam at Fermilab

    Science.gov (United States)

    Langen, Katja; Lennox, Arlene J.; Kroc, Thomas K.; DeLuca, Jr., Paul M.

    2000-06-01

    The Neutron Therapy Facility at Fermilab has treated cancer patients since 1976. Since then more than 2,300 patients have been treated and a wealth of clinical information accumulated. The therapeutic neutron beam at Fermilab is produced by bombarding a beryllium target with 66 MeV protons. The resulting continuous neutron spectrum ranges from thermal to 66 MeV in neutron energy. It is clear that this spectrum is not well suited for the treatment of tumors with boron neutron capture therapy (BNCT) only However, since this spectrum contains thermal and epithermal components the authors are investigating whether BNCT can be used in this beam to boost the tumor dose. There are clinical scenarios in which a selective tumor dose boost of 10 - 15% could be clinically significant. For these cases the principal treatment would still be fast neutron therapy but a tumor boost could be used either to deliver a higher dose to the tumor tissue or to reduce the dose to the normal healthy tissue while maintaining the absorbed dose level in the tumor tissue.

  17. Project SunSHINE: A Student Based Solar Research Program

    Science.gov (United States)

    Donahue, R.

    2000-12-01

    Eastchester Middle School (NY) is currently conducting an ongoing, interdisciplinary solar research program entitled Project SunSHINE, for Students Help Investigate Nature in Eastchester. Students are to determine how ultraviolet and visible light levels vary throughout the year at the school's geographic location, and to ascertain if any measured variations correlate to daily weather conditions or sunspot activity. The educational goal is to provide students the opportunity to conduct original and meaningful scientific research, while learning to work collaboratively with peers and teachers in accordance with national mathematics, science and technology standards. Project SunSHINE requires the student researchers to employ a number of technologies to collect and analyze data, including light sensors, astronomical imaging software, an onsite AirWatch Weather Station, Internet access to retrieve daily solar images from the National Solar Observatory's Kitt Peak Vacuum Telescope, and two wide field telescopes for live sunspot observations. The program has been integrated into the science, mathematics, health and computer technology classes. Solar and weather datasets are emailed weekly to physicist Dr. Gil Yanow of the Jet Propulsion Laboratory for inclusion in his global study of light levels. Dr. Yanow credited the Project SunSHINE student researchers last year for the discovery of an inverse relationship between relative humidity and ultraviolet light levels. The Journal News Golden Apple Awards named Project SunSHINE the 1999 New York Wired Applied Technology Award winner. This honor recognizes the year's outstanding educational technology program at both the elementary and secondary level, and included a grant of \\$20,000 to the research program. Teacher training and image processing software for Project SunSHINE has been supplied by The Use of Astronomy in Research Based Science Education (RBSE), a Teacher Enhancement Program funded by the National Science

  18. Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases

    Energy Technology Data Exchange (ETDEWEB)

    Bakeine, G.J. [Department of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste (Italy)], E-mail: jamesbakeine1@yahoo.com; Di Salvo, M. [Department of Nuclear and Theoretical Physics, University of Pavia, Via Bassi 6, Pavia (Italy); Bortolussi, S.; Stella, S. [Department of Nuclear and Theoretical Physics, University of Pavia, Via Bassi 6, Pavia (Italy); National Institute of Nuclear Physics (INFN) Section of Pavia, Via Bassi 6, Pavia (Italy); Bruschi, P. [Department of Nuclear and Theoretical Physics, University of Pavia, Via Bassi 6, Pavia (Italy); Bertolotti, A.; Nano, R. [Department of Animal Biology University of Pavia, Piazza Botta, Pavia (Italy); Clerici, A.; Ferrari, C.; Zonta, C. [Department of Surgery University of Pavia, Piazza Botta, Pavia (Italy); Marchetti, A. [Scientific Research Office, Fondazione San Matteo University Policlinic, Pavia (Italy); Altieri, S. [Department of Nuclear and Theoretical Physics, University of Pavia, Via Bassi 6, Pavia (Italy); National Institute of Nuclear Physics (INFN) Section of Pavia, Via Bassi 6, Pavia (Italy)

    2009-07-15

    In order for boron neutron capture therapy (BNCT) to be eligible for application in lung tumour disease, three fundamental criteria must be fulfilled: there must be selective uptake of boron in the tumour cells with respect to surrounding healthy tissue, biological effectiveness of the radiation therapy and minimal damage or collateral effects of the irradiation on the surrounding tissues. In this study, we evaluated the biological effectiveness of BNCT by in vitro irradiation of rat colon-carcinoma cells previously incubated in boron-enriched medium. One part of these cells was re-cultured in vitro while the other was inoculated via the inferior vena cava to induce pulmonary metastases in a rat model. We observed a post-irradiation in vitro cell viability of 0.05% after 8 days of cell culture. At 4 months follow-up, all animal subjects in the treatment group that received irradiated boron-containing cells were alive. No animal survived beyond 1 month in the control group that received non-treated cells (p<0.001 Kaplan-Meier). These preliminary findings strongly suggest that BNCT has a significant lethal effect on tumour cells and post irradiation surviving cells lose their malignant capabilities in vivo. This radio-therapeutic potential warrants the investigation of in vivo BNCT for lung tumour metastases.

  19. Evaluation of a College Freshman Diversity Research Program in Astronomy

    Science.gov (United States)

    Tremmel, Michael J.; Garner, S. M.; Schmidt, S. J.; Wisniewski, J. P.; Agol, E.

    2014-01-01

    Graduate students in the astronomy department at the University of Washington began the Pre-Major in Astronomy Program (Pre-MAP) after recognizing that underrepresented students in STEM fields are not well retained after their transition from high school. Pre-MAP is a research and mentoring program that begins with a keystone seminar where they learn astronomical research techniques that they apply to research projects conducted in small groups. Students also receive one-on-one mentoring and peer support for the duration of the academic year and beyond. Successful Pre-MAP students have declared astronomy and physics majors, expanded their research projects beyond the fall quarter, presented posters at the UW Undergraduate Research Symposium, and received research fellowships and summer internships. Here we examine the success of the program in attracting underrepresented minorities and in facilitating better STEM retention and academic performance among incoming UW students. We use the University of Washington Student Database to study both the performance of Pre-MAP students and the overall UW student body over the past 8 years. We show that Pre-MAP students are generally more diverse than the overall UW population and also come in with a variety of different math backgrounds, which we show to be an important factor on STEM performance for the overall UW population. We find that that Pre-MAP students are both more academically successful and more likely to graduate in STEM fields than their UW peers, regardless of initial math placement.

  20. Laboratory Directed Research and Development Program FY98

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, T. [ed.; Chartock, M.

    1999-02-05

    The Ernest Orlando Lawrence Berkeley National Laboratory (LBNL or Berkeley Lab) Laboratory Directed Research and Development Program FY 1998 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development (LDRD) program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The LBNL LDRD program is a critical tool for directing the Laboratory's forefront scientific research capabilities toward vital, excellent, and emerging scientific challenges. The program provides the resources for LBNL scientists to make rapid and significant contributions to critical national science and technology problems. The LDRD program also advances LBNL's core competencies, foundations, and scientific capability, and permits exploration of exciting new opportunities. All projects are work in forefront areas of science and technology. Areas eligible for support include the following: Advanced study of hypotheses, concepts, or innovative approaches to scientific or technical problems; Experiments and analyses directed toward ''proof of principle'' or early determination of the utility of new scientific ideas, technical concepts, or devices; and Conception and preliminary technical analyses of experimental facilities or devices.

  1. Qualitative Research in an International Research Program: Maintaining Momentum while Building Capacity in Nurses

    Directory of Open Access Journals (Sweden)

    Judy Mill RN, PhD

    2014-02-01

    Full Text Available Nurses are knowledgeable about issues that affect quality and equity of care and are well qualified to inform policy, yet their expertise is seldom acknowledged and their input infrequently invited. In 2007, a large multidisciplinary team of researchers and decision-makers from Canada and five low- and middle-income countries (Barbados, Jamaica, Uganda, Kenya, and South Africa received funding to implement a participatory action research (PAR program entitled “Strengthening Nurses' Capacity for HIV Policy Development in sub-Saharan Africa and the Caribbean.” The goal of the research program was to explore and promote nurses' involvement in HIV policy development and to improve nursing practice in countries with a high HIV disease burden. A core element of the PAR program was the enhancement of the research capacity, and particularly qualitative capacity, of nurses through the use of mentorship, role-modeling, and the enhancement of institutional support. In this article we: (a describe the PAR program and research team; (b situate the research program by discussing attitudes to qualitative research in the study countries; (c highlight the incremental formal and informal qualitative research capacity building initiatives undertaken as part of this PAR program; (d describe the approaches used to maintain rigor while implementing a complex research program; and (e identify strategies to ensure that capacity building was locally-owned. We conclude with a discussion of challenges and opportunities and provide an informal analysis of the research capacity that was developed within our international team using a PAR approach.

  2. DTRA's Nuclear Explosion Monitoring Research and Development Program

    Science.gov (United States)

    Nichols, J.; Dainty, A.; Phillips, J.

    2001-05-01

    The Defense Threat Reduction Agency (DTRA) has a Program in Basic Research and Development for Nuclear Explosion Technology within the Nuclear Treaties Branch of the Arms Control Technology Division. While the funding justification is Arms Control Treaties (i.e., Comprehensive Nuclear-Test-Ban Treaty, CTBT), the results are made available for any user. Funding for the Program has averaged around \\10m per year recently. By Congressional mandate, the program has disbursed money through competitive, peer-reviewed, Program Research and Development Announcements (PRDAs); there is usually (but not always) a PRDA each year. Typical awards have been for about three years at ~\\100,000 per year, currently there are over 60 contracts in place. In addition to the "typical" awards, there was an initiative 2000 to fund seismic location calibration of the International Monitoring System (IMS) of the CTBT; there are three three-year contracts of ~\\$1,000,000 per year to perform such calibration for Eurasia, and North Africa and the Middle East. Scientifically, four technological areas have been funded, corresponding to the four technologies in the IMS: seismic, infrasound, hydroacoustic, and radionuclide, with the lion's share of the funding going to the seismic area. The scientific focus of the Program for all four technologies is detection of signals, locating their origin, and trying to determine of they are unambiguously natural in origin ("event screening"). Location has been a particular and continuing focus within the Program.

  3. Scientific Merit Review of Directed Research Tasks Within the NASA Human Research Program

    Science.gov (United States)

    Charles, John B.

    2010-01-01

    The Human Research Program is instrumental in developing and delivering research findings, health countermeasures, and human systems technologies for spacecraft. :HRP is subdivided into 6 research entities, or Elements. Each Element is charged with providing the Program with knowledge and capabilities to conduct research to address the human health and performance risks as well as advance the readiness levels of technology and countermeasures. Project: An Element may be further subdivided into Projects, which are defined as an integrated set of tasks undertaken to deliver a product or set of products

  4. Laboratory Directed Research and Development Program FY 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2002-03-15

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. This is the annual report on Laboratory Directed Research and Development (LDRD) program for FY01.

  5. Future Directions for NCI’s Surveillance Research Program

    Science.gov (United States)

    Since the early 1970s, NCI’s SEER program has been an invaluable resource for statistics on cancer in the United States. For the past several years, SEER researchers have been working toward a much broader and comprehensive goal for providing cancer stati

  6. Army’s Cyber Commander Explores NPS Education, Research Programs

    OpenAIRE

    Naval Postgraduate School Public Affairs Office

    2012-01-01

    Lt. Gen. Rhett A. Hernandez, Commanding General of U.S. Army Cyber Command/U.S. 2nd Army, spent two days at the Naval Postgraduate School for an exploratory review of the university's cyber education and research programs, Oct. 1-2.

  7. Hawaii Integrated Biofuels Research Program: Final Subcontract Report, Phase III

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This report is a compilation of studies done to develop an integrated set of strategies for the production of energy from renewable resources in Hawaii. Because of the close coordination between this program and other ongoing DOE research, the work will have broad-based applicability to the entire United States.

  8. Proceedings of the black liquor research program review fifth meeting

    Energy Technology Data Exchange (ETDEWEB)

    1988-09-01

    On June 14--17, 1988 the participants and invited guests of the Cooperative Program in Kraft Recovery gathered in Charleston, South Carolina, to review progress on four major black liquor research programs being executed at the Institute of Paper Chemistry, the University of Maine, the National Bureau of Standards, and the University of Florida. These programs include: (1) Black Liquor Properties; (2) Black Liquor Droplet Formation; (3) Black Liquor Nozzle Evaluation; and (4) Black Liquor Combustion. In addition to the objectives of previous meetings, this meeting made a direct attempt to gather ideas on how to improve our ability to move from new technology concepts to commercial implementation. Also attached is the agenda for the Charleston meeting. The first two days were involved with updates and reviews of the four major black liquor programs. A half day was spent discussing pathways to implementation and developing thoughts on what industry, DOE and academia could do to facilitate commercial implementation of the research results. This publication is a summary of the presentations made in Charleston and the industry responses to the research work. Readers are cautioned that the contents are in-progress updates on the status of the research and do not represent referred technical papers. Any questions regarding the content should be referred to the principal investigators of the project.

  9. Research Program of the TEXONO Collaboration Status and Highlights

    CERN Document Server

    Wong, H T K; Wong, Henry Tsz-King; Li, Jin

    2002-01-01

    This article reviews the research program and efforts for the TEXONO Collaboration among scientists from Taiwan and China. These include reactor-based neutrino physics at the Kuo-Sheng Power Plant in Taiwan as well as various R&D efforts related to the various experimental techniques in neutrino and astro-particle physics.

  10. Research Reports: 2001 NASA/ASEE Summer Faculty Fellowship Program

    Science.gov (United States)

    Karr, G. (Editor); Pruitt, J. (Editor); Nash-Stevenson, S. (Editor); Freeman, L. M. (Editor); Karr, C. L. (Editor)

    2002-01-01

    For the thirty-seventh consecutive year, a NASA/ASEE (American Society for Engineering Education) Summer Faculty Fellowship Program was conducted at Marshall Space Flight Center (MSFC). The program was conducted by The University of Alabama in Huntsville and MSFC during the period May 29 - August 3, 2001. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA Centers, was sponsored by the University Affairs Office, NASA Headquarters, Washington, DC. The basic objectives of the programs, which are in the thirty-seventh year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. The Faculty Fellows spent ten weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 2001.

  11. Observations concerning Research Literature on Neuro-Linguistic Programming.

    Science.gov (United States)

    Einspruch, Eric L.; Forman, Bruce D.

    1985-01-01

    Identifies six categories of design and methodological errors contained in the 39 empirical studies of neurolinguistic programming (NLP) documented through April 1984. Representative reports reflecting each category are discussed. Suggestions are offered for improving the quality of research on NLP. (Author/MCF)

  12. Benefits of Supervised Agricultural Experience Programs: A Synthesis of Research.

    Science.gov (United States)

    Williams, David L.; Dyer, James E.

    1997-01-01

    A review of literature from 1964 to 1993 identified the benefits of supervised agricultural experience (SAE) programs, including agriculture knowledge and positive work attitudes. Classroom, SAE, and Future Farmers of America complemented each other. The research base is state specific and fragmented and lacks cohesiveness. (SK)

  13. The Jornada Basin long term ecological research program

    Science.gov (United States)

    Chihuahuan Desert landscapes exemplify the ecological conditions, vulnerability, and management challenges in arid and semi-arid regions around the world. The goal of the Jornada Basin Long Term Ecological Research program (JRN LTER) established in 1982 is to understand and quantify the key factors ...

  14. NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.

  15. Conclusions, Reflections, and Prospects for Future Research, Policy, and Programming

    Science.gov (United States)

    Clark-Kazak, Christina

    2012-01-01

    This concluding chapter draws together some of the key themes from the contributions and proposes some recommended areas for future research, policy, and programming. It highlights the artificiality of categorization processes related to both migration and childhood that independent child migrants encounter, and problematizes the…

  16. INL Advanced Radiotherapy Research Program Annual Report 2004

    Energy Technology Data Exchange (ETDEWEB)

    James Venhuizen

    2005-06-01

    This report summarizes the activities and major accomplishments for the Idaho National Laboratory Advanced Radiotherapy Research Program for calendar year 2004. Topics covered include boron analysis in biological samples, computational dosimetry and treatment planning software development, medical neutron source development and characterization, and collaborative dosimetry studies at the RA-1 facility in Buenos Aires, Argentina.

  17. Equilibration: Developing the Hard Core of the Piagetian Research Program.

    Science.gov (United States)

    Rowell, J.A.

    1983-01-01

    Argues that the status of the concept of equilibration is classified by considering Piagetian theory as a research program in the sense elaborated in 1974 by Lakatos. A pilot study was made to examine the precision and testability of equilibration in Piaget's 1977 model.(Author/RH)

  18. Federal Geothermal Research Program Update Fiscal Year 2003

    Energy Technology Data Exchange (ETDEWEB)

    2004-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The following mission and goal statements guide the overall activities of the Office. The goals are: (1) Reduce the levelized cost of generating geothermal power to 3-5 cents per kWh by 2007; (2) Double the number of States with geothermal electric power facilities to eight by 2006; and (3) Supply the electrical power or heat energy needs of 7 million homes and businesses in the United States by 2010. This Federal Geothermal Program Research Update reviews the accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2003. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy. balanced strategy for the Geothermal Program.

  19. INEEL Advanced Radiotherapy Research Program Annual Report for 2002

    Energy Technology Data Exchange (ETDEWEB)

    J. R. Venhuizen

    2003-05-01

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  20. INEEL Advanced Radiotherapy Research Program Annual Report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    2003-05-23

    This report summarizes the activities and major accomplishments for the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2002. Topics covered include computational dosimetry and treatment planning software development, medical neutron source development and characterization, and boron analytical chemistry.

  1. Postdoctoral Fellowship Program in Educational Research. Final Report.

    Science.gov (United States)

    Coleman, James S.

    This postdoctoral fellowship program involved the following three phases: 1) systematic instruction in the sociology of complex organizations with particular emphasis on the organizational analysis of schools and schooling; 2) systematic instruction in multivariate regression approaches to non-experimental research with particular emphasis on…

  2. Federal Geothermal Research Program Update Fiscal Year 2002

    Energy Technology Data Exchange (ETDEWEB)

    2003-09-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The goals are: (1) Double the number of States with geothermal electric power facilities to eight by 2006; (2) Reduce the levelized cost of generating geothermal power to 3-5 cents per kWh by 2007; and (3) Supply the electrical power or heat energy needs of 7 million homes and businesses in the United States by 2010. This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2002. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy. balanced strategy for the Geothermal Program.

  3. Laboratory directed research and development program FY 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd; Levy, Karin

    2000-03-08

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. This is the annual report on Laboratory Directed Research and Development (LDRD) program for FY99.

  4. Atmospheric Science Program. Summaries of research in FY 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report provides descriptions for all projects funded by ESD under annual contracts in FY 1994. Each description contains the project`s title; three-year funding history (in thousands of dollars); the contract period over which the funding applies; the name(s) of the principal investigator(s); the institution(s) conducting the projects; and the project`s objectives, products, approach, and results to date (for most projects older than one year). Project descriptions are categorized within the report according to program areas: atmospheric chemistry, atmospheric dynamics, and support operations. Within these categories, the descriptions are ordered alphabetically by principal investigator. Each program area is preceded by a brief text that defines the program area, states it goals and objectives, lists principal research questions, and identifies program managers. Appendixes provide the addresses and telephone numbers of the principal investigators and define the acronyms used.

  5. Legacy of Biomedical Research During the Space Shuttle Program

    Science.gov (United States)

    Hayes, Judith C.

    2011-01-01

    The Space Shuttle Program provided many opportunities to study the role of spaceflight on human life for over 30 years and represented the longest and largest US human spaceflight program. Outcomes of the research were understanding the effect of spaceflight on human physiology and performance, countermeasures, operational protocols, and hardware. The Shuttle flights were relatively short, Biomedical research was conducted on the Space Shuttle using various vehicle resources. Specially constructed pressurized laboratories called Spacelab and SPACEHAB housed many laboratory instruments to accomplish experiments in the Shuttle s large payload bay. In addition to these laboratory flights, nearly every mission had dedicated human life science research experiments conducted in the Shuttle middeck. Most Shuttle astronauts participated in some life sciences research experiments either as test subjects or test operators. While middeck experiments resulted in a low sample per mission compared to many Earth-based studies, this participation allowed investigators to have repetition of tests over the years on successive Shuttle flights. In addition, as a prelude to the International Space Station (ISS), NASA used the Space Shuttle as a platform for assessing future ISS hardware systems and procedures. The purpose of this panel is to provide an understanding of science integration activities required to implement Shuttle research, review biomedical research, characterize countermeasures developed for Shuttle and ISS as well as discuss lessons learned that may support commercial crew endeavors. Panel topics include research integration, cardiovascular physiology, neurosciences, skeletal muscle, and exercise physiology. Learning Objective: The panel provides an overview from the Space Shuttle Program regarding research integration, scientific results, lessons learned from biomedical research and countermeasure development.

  6. Research Mentorship Program (RMP to Enhance the Research Productivity in a Psychiatric Hospital: First Report

    Directory of Open Access Journals (Sweden)

    Zhila Afshar

    2011-12-01

    Full Text Available Background: Despite rapid movement in student research in recent years, there is still little evidence that shows the impact of students' activities on research productivity. In this RMP (Research Mentorship Program, we have tried to create a link between medical students with little experience and the professors in the field of medicine. This research was led by a group of medical students who are highly experienced in research. The aim of this study has been to evaluate the impact of the RMP on research productivity.Methods: The Research Mentorship Program began in July 2009 and the program continued for 6 months. After that initial period, the results were evaluated following another 18 months. Some of the interventions included: introducing the RMP to the students; student meetings of the RMP; meetings with the professors; designing a psychiatric history and mental status examination checklist; and research workshops.Results: In eleven semi years, the research productivity scores were evaluated, including eight semi years before interventions and 3 semi years after it. The results show a significant increase in the research productivity score after the RMP in comparison to the research productivity score before it (P-value=0.047. The mean RPS before the RMP was 16.56±7.30 and the score changed to 28.16±7.94 after the RMP.Conclusions: This study shows that with suitable interventions the student researcher’s have the potential to increase research productivity.

  7. Federal Geothermal Research Program Update Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, J.L.

    2001-08-15

    The Department of Energy's Geothermal Program serves two broad purposes: (1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and (2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  8. NASA's Upper Atmosphere Research Program (UARP) and Atmospheric Chemistry Modeling and Analysis Program (ACMAP): Research Summaries 1997-1999

    Science.gov (United States)

    Kurylo, M. J.; DeCola, P. L.; Kaye, J. A.

    2000-01-01

    Under the mandate contained in the FY 1976 NASA Authorization Act, the National Aeronautics and Space Administration (NASA) has developed and is implementing a comprehensive program of research, technology development, and monitoring of the Earth's upper atmosphere, with emphasis on the upper troposphere and stratosphere. This program aims at expanding our chemical and physical understanding to permit both the quantitative analysis of current perturbations as well as the assessment of possible future changes in this important region of our environment. It is carried out jointly by the Upper Atmosphere Research Program (UARP) and the Atmospheric Chemistry Modeling and Analysis Program (ACMAP), both managed within the Research Division in the Office of Earth Science at NASA. Significant contributions to this effort have also been provided by the Atmospheric Effects of Aviation Project (AEAP) of NASA's Office of Aero-Space Technology. The long-term objectives of the present program are to perform research to: understand the physics, chemistry, and transport processes of the upper troposphere and the stratosphere and their control on the distribution of atmospheric chemical species such as ozone; assess possible perturbations to the composition of the atmosphere caused by human activities and natural phenomena (with a specific emphasis on trace gas geographical distributions, sources, and sinks and the role of trace gases in defining the chemical composition of the upper atmosphere); understand the processes affecting the distributions of radiatively active species in the atmosphere, and the importance of chemical-radiative-dynamical feedbacks on the meteorology and climatology of the stratosphere and troposphere; and understand ozone production, loss, and recovery in an atmosphere with increasing abundances of greenhouse gases. The current report is composed of two parts. Part 1 summarizes the objectives, status, and accomplishments of the research tasks supported

  9. 77 FR 46909 - Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR...

    Science.gov (United States)

    2012-08-06

    ... Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program Policy Directives... Small Business Innovation Research (SBIR) and Small Business Technology Transfer Program (STTR) Policy... Webinars will be conducted by SBA's Office of Investment and Innovation. For additional information,...

  10. Evaluating the High School Lunar Research Projects Program

    Science.gov (United States)

    Shaner, A. J.; Shipp, S. S.; Allen, J.; Kring, D. A.

    2012-12-01

    The Center for Lunar Science and Exploration (CLSE), a collaboration between the Lunar and Planetary Institute and NASA's Johnson Space Center, is one of seven member teams of the NASA Lunar Science Institute (NLSI). In addition to research and exploration activities, the CLSE team is deeply invested in education and outreach. In support of NASA's and NLSI's objective to train the next generation of scientists, CLSE's High School Lunar Research Projects program is a conduit through which high school students can actively participate in lunar science and learn about pathways into scientific careers. The objectives of the program are to enhance 1) student views of the nature of science; 2) student attitudes toward science and science careers; and 3) student knowledge of lunar science. In its first three years, approximately 140 students and 28 teachers from across the United States have participated in the program. Before beginning their research, students undertake Moon 101, a guided-inquiry activity designed to familiarize them with lunar science and exploration. Following Moon 101, and guided by a lunar scientist mentor, teams choose a research topic, ask their own research question, and design their own research approach to direct their investigation. At the conclusion of their research, teams present their results to a panel of lunar scientists. This panel selects four posters to be presented at the annual Lunar Science Forum held at NASA Ames. The top scoring team travels to the forum to present their research. Three instruments have been developed or modified to evaluate the extent to which the High School Lunar Research Projects meets its objectives. These three instruments measure changes in student views of the nature of science, attitudes towards science and science careers, and knowledge of lunar science. Exit surveys for teachers, students, and mentors were also developed to elicit general feedback about the program and its impact. The nature of science

  11. Federal Geothermal Research Program Update Fiscal Year 1998

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.G.

    1999-05-01

    This report reviews the specific objectives, status, and accomplishments of DOE's Geothermal Research Program for Fiscal Year 1998. The Exploration Technology research area focuses on developing instruments and techniques to discover hidden hydrothermal systems and to expose the deep portions of known systems. The Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal and hot dry rock reservoirs. The Drilling Technology projects focus on developing improved, economic drilling and completion technology for geothermal wells. The Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Direct use research covers the direct use of geothermal energy sources for applications in other than electrical production.

  12. Integrated research training program of excellence in radiochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Lapi, Suzanne [Washington Univ., St. Louis, MO (United States)

    2015-09-18

    The overall goal of this “Integrated Research Training Program of Excellence in Radiochemistry” is to provide a rich and deep research experience in state-of-the-art radiochemistry and in the fundamentals of radioisotopic labeling and tracer methodology to develop researchers who are capable of meeting the challenges of designing and preparing radiotracers of broad applicability for monitoring and imaging diverse biological systems and environmental processes. This program was based in the Departments of Radiology and Radiation Oncology at Washington University Medical School and the Department of Chemistry at the University of Illinois at Urbana Champaign, and it was initially directed by Professor Michael J. Welch as Principal Investigator. After his passing in 2012, the program was led by Professor Suzanne E. Lapi. Programmatic content and participant progress was overseen by an Internal Advisory Committee of senior investigators consisting of the PIs, Professor Mach from the Department of Radiology at Washington University and Professor John A. Katzenellenbogen of the Department of Chemistry at the University of Illinois. A small External Advisory Committee to give overall program guidance was also constituted of experts in radiolabeled compounds and in their applications in environmental and plant science.

  13. DOE (Department of Energy) Epidemiologic Research Program: Selected bibliography

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and from the operation of DOE facilities. The program has been divided into seven general areas of activity: the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the genetic aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 380 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliograhpy is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by national laboratory and by year. Multi-authored studies are indicated only once, according to the main supporting laboratory.

  14. USAF Summer Research Program - 1995 Summer Faculty Research Program Final Reports, Volume 5A, Wright Laboratory

    Science.gov (United States)

    1995-12-01

    Summer Faculty Program at WL/MT in addition to those named above. Al Taylor John Cantrell Shirley Henderson Mary Lewis Bill Brown Bob Reifenberg Mickey...Way. TQC towa Nanika-Nipponteki Hinshitsu Kanri. Prentice Hall, Inc. Englewood Cliffs. 1985. Katzenbach , Jon R. and Douglas K. Smith. The Wisdom of...36(3), 301 (1993). [2] A. I. Akinwande, P. P. Ruden, B. L. Goldenberg, D. K. Arch, and John King, Proceedings of 1994 Tri-Service (NASA) Cathode

  15. NSF's Experimental Program to Stimulate Competitive Research (EPSCoR): Subsidizing Academic Research or State Budgets?

    Science.gov (United States)

    Wu, Yonghong

    2009-01-01

    This cross-state empirical study focuses on the National Science Foundation's (NSF) Experimental Program to Stimulate Competitive Research (EPSCoR) and examines its impact on the academic research and development (R&D) expenditures financed by state governments. Based on a panel of 50 states during 1979-2006, the empirical results indicate that…

  16. Research reports: 1990 NASA/ASEE Summer Faculty Fellowship Program

    Science.gov (United States)

    Anderson, Loren A. (Editor); Beymer, Mark A. (Editor)

    1990-01-01

    A collection of technical reports on research conducted by the participants in this program is presented. The topics covered include: human-computer interface software, multimode fiber optic communication links, electrochemical impedance spectroscopy, rocket-triggered lightning, robotics, a flammability study of thin polymeric film materials, a vortex shedding flowmeter, modeling of flow systems, monomethyl hydrazine vapor detection, a rocket noise filter system using digital filters, computer programs, lower body negative pressure, closed ecological systems, and others. Several reports with respect to space shuttle orbiters are presented.

  17. Research in mathematical theory of computation. [computer programming applications

    Science.gov (United States)

    Mccarthy, J.

    1973-01-01

    Research progress in the following areas is reviewed: (1) new version of computer program LCF (logic for computable functions) including a facility to search for proofs automatically; (2) the description of the language PASCAL in terms of both LCF and in first order logic; (3) discussion of LISP semantics in LCF and attempt to prove the correctness of the London compilers in a formal way; (4) design of both special purpose and domain independent proving procedures specifically program correctness in mind; (5) design of languages for describing such proof procedures; and (6) the embedding of ideas in the first order checker.

  18. Advanced parallel programming models research and development opportunities.

    Energy Technology Data Exchange (ETDEWEB)

    Wen, Zhaofang.; Brightwell, Ronald Brian

    2004-07-01

    There is currently a large research and development effort within the high-performance computing community on advanced parallel programming models. This research can potentially have an impact on parallel applications, system software, and computing architectures in the next several years. Given Sandia's expertise and unique perspective in these areas, particularly on very large-scale systems, there are many areas in which Sandia can contribute to this effort. This technical report provides a survey of past and present parallel programming model research projects and provides a detailed description of the Partitioned Global Address Space (PGAS) programming model. The PGAS model may offer several improvements over the traditional distributed memory message passing model, which is the dominant model currently being used at Sandia. This technical report discusses these potential benefits and outlines specific areas where Sandia's expertise could contribute to current research activities. In particular, we describe several projects in the areas of high-performance networking, operating systems and parallel runtime systems, compilers, application development, and performance evaluation.

  19. A research agenda for academic petroleum engineering programs. [Final report

    Energy Technology Data Exchange (ETDEWEB)

    Calhoun, J.C. Jr.

    1990-03-31

    The development of a research agenda should be a direct way of portraying the scope of petroleum engineering, of identifying the critical technological issues faced by the profession,of elucidating the gaps between the existing research resources and the needs. and of outlining a program of research through which the petroleum engineering departments can be collectively of maximum service. Such an agenda would be of value to the profession of petroleum engineering, to industry and to government agencies, as well as to the faculty and students of the petroleum engineering departments. The purposes of the activity that led to this report, therefore, were to develop a statement to serve as a beginning research agenda for the petroleum engineering academic community; to bring together representatives of the petroleum engineering academic community to recognize the importance of developing a consensus posture with respect to research; and to provide a document that will assist in portraying to industry, government agencies and others the problems and needs of the petroleum engineering departments for conducting research. Contents of this report include; introduction; the background; the scope of petroleum engineering research; priority research topics and technological issues; non-technological research issues; and conclusions and recommendations.

  20. A research agenda for academic petroleum engineering programs

    Energy Technology Data Exchange (ETDEWEB)

    Calhoun, J.C. Jr.

    1990-03-31

    The development of a research agenda should be a direct way of portraying the scope of petroleum engineering, of identifying the critical technological issues faced by the profession,of elucidating the gaps between the existing research resources and the needs. and of outlining a program of research through which the petroleum engineering departments can be collectively of maximum service. Such an agenda would be of value to the profession of petroleum engineering, to industry and to government agencies, as well as to the faculty and students of the petroleum engineering departments. The purposes of the activity that led to this report, therefore, were to develop a statement to serve as a beginning research agenda for the petroleum engineering academic community; to bring together representatives of the petroleum engineering academic community to recognize the importance of developing a consensus posture with respect to research; and to provide a document that will assist in portraying to industry, government agencies and others the problems and needs of the petroleum engineering departments for conducting research. Contents of this report include; introduction; the background; the scope of petroleum engineering research; priority research topics and technological issues; non-technological research issues; and conclusions and recommendations.

  1. 78 FR 29121 - Strategic Environmental Research and Development Program, Scientific Advisory Board; Notice of...

    Science.gov (United States)

    2013-05-17

    ... of the Secretary Strategic Environmental Research and Development Program, Scientific Advisory Board... open meeting of the Strategic Environmental Research and Development Program, Scientific Advisory Board... 12, 2013 meeting is to review new start research and development projects requesting...

  2. 78 FR 29122 - Strategic Environmental Research and Development Program, Scientific Advisory Board; Notice of...

    Science.gov (United States)

    2013-05-17

    ... of the Secretary Strategic Environmental Research and Development Program, Scientific Advisory Board... open meeting of the Strategic Environmental Research and Development Program, Scientific Advisory Board... 13, 2013 meeting is to review continuing research and development projects requesting...

  3. 76 FR 38134 - Final Priorities; Disability and Rehabilitation Research Projects and Centers Program-Disability...

    Science.gov (United States)

    2011-06-29

    ... Final Priorities; Disability and Rehabilitation Research Projects and Centers Program--Disability...; Disability and Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research Projects (DRRP)--Americans with Disabilities Act (ADA) National Network Regional Centers (formerly...

  4. The use of Grossone in Mathematical Programming and Operations Research

    CERN Document Server

    De Cosmis, Sonia

    2011-01-01

    The concepts of infinity and infinitesimal in mathematics date back to anciens Greek and have always attracted great attention. Very recently, a new methodology has been proposed by Sergeyev for performing calculations with infinite and infinitesimal quantities, by introducing an infinite unit of measure expressed by the numeral grossone. An important characteristic of this novel approach is its attention to numerical aspects. In this paper we will present some possible applications and use of grossone in Operations Research and Mathematical Programming. In particular, we will show how the use of grossone can be beneficial in anti--cycling procedure for the well-known simplex method for solving Linear Programming Problems and in defining exact differentiable Penalty Functions in Nonlinear Programming.

  5. Sourcing Program: To identify outstanding women and ethnic minorities in research and research management

    Energy Technology Data Exchange (ETDEWEB)

    Nissen, S.H.

    1991-08-01

    To meet the challenges of the changing demographics and a projected shortage of technically trained workers in the 21st century, Lawrence Livermore National (LLNL) is increasing its commitment to develop a diverse work force with the abilities to carry out the Laboratory's missions. In addition to the recruitment programs already established at LLNL, a sourcing program to identify outstanding women and minorities in research and research management was initiated in the summer of 1990. A research methodology, time table, selection criteria, and data generation strategy were designed and implemented for this program. Through extensive contacts with R D facilities, women's and minority professional organizations, national research councils, technical professional societies and universities, other sourcing programs were investigated and evaluated and a network of contacts and resources was developed. This report describes the design and implementation of the sourcing program targeting outstanding women and minorities in science and engineering. It details the investigation and evaluation of sourcing programs in other R D facilities and provides information regarding methods and sources used to identify potential candidates. Conclusions and recommendations are presented. 10 refs., 5 tabs.

  6. LABORATORY DIRECTED RESEARCH AND DEVELOPMENT PROGRAM ACTIVITIES FOR FY2002.

    Energy Technology Data Exchange (ETDEWEB)

    FOX,K.J.

    2002-12-31

    Brookhaven National (BNL) Laboratory is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, under contract with the U. S. Department of Energy. BNL's total annual budget has averaged about $450 million. There are about 3,000 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 4 1 3.2A, ''Laboratory Directed Research and Development,'' January 8, 2001, and the LDRD Annual Report guidance, updated February 12, 1999. The LDRD Program obtains its funds through the Laboratory overhead pool and operates under the authority of DOE Order 413.2A. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new ''fundable'' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research ''which could lead to new programs, projects, and directions'' for the Laboratory. As one of the premier scientific laboratories of the DOE, BNL must continuously foster groundbreaking scientific research. At Brookhaven National Laboratory one such method is through its LDRD Program. This discretionary research and development tool is critical in maintaining the scientific excellence and long-term vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community and foster new science and technology

  7. Environmental Systems Research Candidates Program--FY2000 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Piet, Steven James

    2001-01-01

    The Environmental Systems Research Candidates (ESRC) Program, which is scheduled to end September 2001, was established in April 2000 as part of the Environmental Systems Research and Analysis Program at the Idaho National Engineering and Environmental Laboratory (INEEL) to provide key science and technology to meet the clean-up mission of the U.S. Department of Energy Office of Environmental Management, and perform research and development that will help solve current legacy problems and enhance the INEEL’s scientific and technical capability for solving longer-term challenges. This report documents the progress and accomplishments of the ESRC Program from April through September 2000. The ESRC Program consists of 24 tasks subdivided within four research areas: A. Environmental Characterization Science and Technology. This research explores new data acquisition, processing, and interpretation methods that support cleanup and long-term stewardship decisions. B. Subsurface Understanding. This research expands understanding of the biology, chemistry, physics, hydrology, and geology needed to improve models of contamination problems in the earth’s subsurface. C. Environmental Computational Modeling. This research develops INEEL computing capability for modeling subsurface contaminants and contaminated facilities. D. Environmental Systems Science and Technology. This research explores novel processes to treat waste and decontaminate facilities. Our accomplishments during FY 2000 include the following: • We determined, through analysis of samples taken in and around the INEEL site, that mercury emissions from the INEEL calciner have not raised regional off-INEEL mercury contamination levels above normal background. • We have initially demonstrated the use of x-ray fluorescence to image uranium and heavy metal concentrations in soil samples. • We increased our understanding of the subsurface environment; applying mathematical complexity theory to the problem of

  8. Interdisciplinary research and training program in the plant sciences

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, C.P.

    1991-01-01

    This document is the compiled progress reports from the Interdisciplinary Research and Training Program in the Plant Sciences funded through the MSU-DOE Plant Research Laboratory. Fourteen reports are included, covering topics such as the molecular basis of plant/microbe symbiosis, cell wall proteins and assembly, gene expression, stress responses, growth regulator biosynthesis, interaction between nuclear and organelle genomes, sensory transduction and tropisms, intracellular sorting and membrane trafficking, regulation of lipid metabolism, the molecular basis of disease resistance and plant pathogenesis, developmental biology of Cyanobacteria and hormonal involvement in environmental control of plant growth. 132 refs. (MHB)

  9. Status of GEA review of DOE geothermal research program

    Energy Technology Data Exchange (ETDEWEB)

    Wright, P.M.

    1996-12-31

    The Geothermal Energy Association (GEA) will be conducting a series of workshops related to the DOE Research and Development (R&D) program, the first of which will take place tomorrow and the next day. This workshop will be focussing on drilling research and development. The objective of these workshops is to provide information and recommendations to DOE on the R&D needs and priorities of the geothermal industry. As a GEA officer, I will be conducting these workshops and it is something you might guess I am interested in. I have been interested in geothermal R&D for 20 years now.

  10. Laboratory Directed Research and Development Program, FY 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    This report is compiled from annual reports submitted by principal investigators following the close of the 1992 fiscal year. It describes the projects supported and summarizes their accomplishments. It constitutes a part of the Laboratory Directed Research and Development program planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The Divisions that report include: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment and Safety and Health, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics and Structural Biology.

  11. A Summary of the Foundation Research Program, FY 1984.

    Science.gov (United States)

    1986-04-30

    Scattering in a Random Ocean - A Linear Systems Theory Approach 34 DEPARTMENT OF METEOROLOGY 35 Investigation of the Structure and Evolution of. the Coastal... Linear Systems Theory Approach DEPARTMENT OF METEOROLOGY Investigation of the Structure W.J. Shaw 6.1 and Evolution of the Coastal ABL Using an Acoustic... Systems Theory Approach INVESTIGATOR: L. J. Ziomek, Assistant Professor of Electrical and Computer Engineering SPONSOR: NPS Foundation Research Program

  12. The National Shipbuilding Research Program. Process Analysis Via Accuracy Control

    Science.gov (United States)

    1985-08-01

    Process Analysis Via Accuracy Control U.S. DEPARTMENT OF TRANSPORTATION Maritime Administration in cooperation with Todd Pacific Shipyards...AUG 1985 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE The National Shipbuilding Research Program Process Analysis Via...lighting, retraining work- ers, or other such approaches. This product of A/C is called process or method analysis. Process analysis involves a

  13. Fossil Energy Advanced Research and Technology Development Materials Program

    Energy Technology Data Exchange (ETDEWEB)

    Cole, N.C.; Judkins, R.R. (comps.)

    1992-12-01

    Objective of this materials program is to conduct R and D on materials for fossil energy applications with focus on longer-term and generic needs of the various fossil fuel technologies. The projects are organized according to materials research areas: (1) ceramics, (2) new alloys: iron aluminides, advanced austenitics and chromium niobium alloys, and (3) technology development and transfer. Separate abstracts have been prepared.

  14. Defend your research corporate wellness programs make us unwell

    OpenAIRE

    Berinato, S.; Spicer, A

    2015-01-01

    The research: André Spicer, a professor at Cass Business School at City University London, conducted a cultural and historical analysis of ideas about wellness in companies (which he published in a recent book, The Wellness Syndrome, coauthored by Stockholm University’s Carl Cederström). He concluded that corporate wellness programs not only provide low returns on investment but actually backfire, making many employees less healthy and more anxious about their jobs. The challenge: Are “fu...

  15. Research Experience for Undergraduates: an International Program Enhancing Interdisciplinary Learning

    Science.gov (United States)

    Pfiffner, S. M.; Davis, K. L.; Phelps, T. J.; Kieft, T. L.; Gihring, T. M.; Onstott, T. C.; Nthangeni, B.; Piater, L.; van Heerden, E.

    2004-12-01

    This NSF-funded research experience for undergraduates (REU) took place in South Africa, where gold mines provided outstanding field sites to investigate biogeochemical processes in deep subsurface environments. Underrepresented minorities were encouraged to participate. Cross-disciplinary training was a major ambition for this REU Site: Biogeochemical Educational Experiences - South Africa. Students were selected from diverse academic disciplines (biology, chemistry, and geology) to participate in this interdisciplinary research program. Research projects included characterizing microbial communities with molecular and biochemical techniques, cultivating microorganisms, utilizing geochemical and isotopic parameters to constrain nutrient cycling in groundwater, investigating extreme enzymes and examining functional genes. During the REU, students collected biofilms and fissure water emanating from gas-rich boreholes in 2-3 km deep mines and performed laboratory research in teams under joint mentorship of U.S. and South African scientists. Research teams consisted of three to five students with at least one student from each country and at least two of the disciplines represented. Team membership reflected students' ranking of their choices among mentor-proposed projects. The REU encouraged students to increase scientific knowledge across disciplines, improve oral and written communication skills, and explore cultural and international challenges for scientific research in the global community. Each research team presented oral progress reports to the other research teams to provide communication skill development and to provide a forum for data exchange and interpretation among the various disciplines. Oral communication training culminated in a public presentation by each team at a university/industry science symposium. Mentors reviewed students' writing skills as they prepared text on experimental design, research findings, data interpretation, and literature

  16. Laboratory Directed Research and Development Program FY 2007 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2008-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries for all ORNL LDRD research activities supported during FY 2007. The associated FY 2007 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching mission to advance the national, economic, and energy security of the United States and promote scientific and technological innovation in support of that mission. As a national resource, the Laboratory also applies its capabilities and skills to specific needs of other federal agencies and customers through the DOE Work for Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at http://www.ornl.gov/. LDRD is a relatively small but vital DOE program that allows ORNL, as well as other DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating

  17. Laboratory Directed Research and Development Program FY 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2006-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2005 and includes final reports for completed projects and shorter progress reports for projects that were active, but not completed, during this period. The FY 2005 ORNL LDRD Self-Assessment (ORNL/PPA-2006/2) provides financial data about the FY 2005 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the

  18. Laboratory Directed Research and Development Program FY 2004 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2005-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2004 and includes final reports for completed projects and shorter progress reports for projects that were active, but not completed, during this period. The FY 2004 ORNL LDRD Self-Assessment (ORNL/PPA-2005/2) provides financial data about the FY 2004 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the

  19. Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats

    Energy Technology Data Exchange (ETDEWEB)

    Emiliano C. C. Pozzi; Veronica A. Trivilin; Lucas L. Colombo; Andrea Monti Hughes; Silvia I. Thorp; Jorge E. Cardoso; Marcel A. Garabalino; Ana J. Molinari; Elisa M. Heber; Paula Curotto; Marcelo Miller; Maria E. Itoiz; Romina F. Aromando; David W. Nigg; Amanda E. Schwint

    2013-11-01

    Boron neutron capture therapy (BNCT) was proposed for untreatable colorectal liver metastases. Employing an experimental model of liver metastases in rats, we recently demonstrated that BNCT mediated by boronophenylalanine (BPA-BNCT) at 13 Gy prescribed to tumor is therapeutically useful at 3-week follow-up. The aim of the present study was to evaluate dose–response at 5-week follow-up, based on retrospective dose assessment in individual rats. BDIX rats were inoculated with syngeneic colon cancer cells DHD/K12/TRb. Tumor-bearing animals were divided into three groups: BPA-BNCT (n = 19), Beam only (n = 8) and Sham (n = 7) (matched manipulation, no treatment). For each rat, neutron flux was measured in situ and boron content was measured in a pre-irradiation blood sample for retrospective individual dose assessment. For statistical analysis (ANOVA), individual data for the BPA-BNCT group were pooled according to absorbed tumor dose, BPA-BNCT I: 4.5–8.9 Gy and BPA-BNCT II: 9.2–16 Gy. At 5 weeks post-irradiation, the tumor surface area post-treatment/pre-treatment ratio was 12.2 +/- 6.6 for Sham, 7.8 +/- 4.1 for Beam only, 4.4 +/- 5.6 for BPA-BNCT I and 0.45 +/- 0.20 for BPA-BNCT II; tumor nodule weight was 750 +/- 480 mg for Sham, 960 +/- 620 mg for Beam only, 380 +/- 720 mg for BPA-BNCT I and 7.3 +/- 5.9 mg for BPA-BNCT II. The BPA-BNCT II group exhibited statistically significant tumor control with no contributory liver toxicity. Potential threshold doses for tumor response and significant tumor control were established at 6.1 and 9.2 Gy, respectively.

  20. Laboratory Directed Research and Development Program. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new ``fundable`` R&D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  1. From Mice to Men: research models of developmental programming.

    Science.gov (United States)

    Rabadán-Diehl, C; Nathanielsz, P

    2013-02-01

    Developmental programming can be defined as a response to a specific challenge to the mammalian organism during a critical developmental time window that alters the trajectory of development with persistent effects on offspring phenotype and predisposition to future illness. We focus on the need for studies in relevant, well-characterized animal models in the context of recent research discoveries on the challenges, mechanisms and outcomes of developmental programming. We discuss commonalities and differences in general principles of developmental programming as they apply to several species, including humans. The consequences of these differences are discussed. Obesity, metabolic disorders and cardiovascular diseases are associated with the highest percentage of morbidity and mortality worldwide. Although many of the causes are associated with lifestyle, high-energy diets and lack of physical activity, recent evidence has linked developmental programming to the epidemic of metabolic diseases. A better understanding of comparative systems physiology of mother, fetus and neonate using information provided by rapid advances in molecular biology has the potential to improve the lifetime health of future generations by providing better women's health, diagnostic tools and preventative and therapeutic interventions in individuals exposed during their development to programming influences.

  2. [Development of advanced educational programs, including research programs, for undergraduate students in National Universities: the facts in 2010].

    Science.gov (United States)

    Kurosaki, Yuji; Tomioka, Yoshihisa; Santa, Tomofumi; Kitamura, Yoshihisa

    2012-01-01

    This article summarizes detailed facts obtained from the questionnaire conducted in 2010 at about 14 National Universities on the topic of "Research programs and advanced educational programs for undergraduate students". The contents of the questionnaire included: (1) Research programs based on the coalition of university and hospital and/or community pharmacy, other Graduate Schools, such as School of Medicine etc., and the University Hospital, (2) Educational systems for the achievement of research programs and their research outcomes, (3) Research programs based on pharmacist practices, (4) Ongoing advanced educational programs for undergraduate students, taking advantage of the coalition with Graduate School, School of Medicine (and Dentistry), and University Hospital. Some of the advanced educational programs outlined in this questionnaire will be carried out by our group in the coming years and the educational benefits together with associated problems shall as well be clarified. This approach will be informative for the development of the leader-oriented pharmacist programs for the college of Pharmacy.

  3. (9)Be(d,n)(10)B-based neutron sources for BNCT.

    Science.gov (United States)

    Capoulat, M E; Herrera, M S; Minsky, D M; González, S J; Kreiner, A J

    2014-06-01

    In the frame of accelerator-based BNCT, the (9)Be(d,n)(10)B reaction was investigated as a possible source of epithermal neutrons. In order to determine the configuration in terms of bombarding energy, target thickness and Beam Shaping Assembly (BSA) design that results in the best possible beam quality, a systematic optimization study was carried out. From this study, the optimal configuration resulted in tumor doses ≥40Gy-Eq, with a maximum value of 51Gy-Eq at a depth of about 2.7cm, in a 60min treatment. The optimal configuration was considered for the treatment planning assessment of a real Glioblastoma Multiforme case. From this, the resulted dose performances were comparable to those obtained with an optimized (7)Li(p,n)-based neutron source, under identical conditions and subjected to the same clinical protocol.

  4. A novel design of beam shaping assembly to use D-T neutron generator for BNCT.

    Science.gov (United States)

    Kasesaz, Yaser; Karimi, Marjan

    2016-12-01

    In order to use 14.1MeV neutrons produced by d-T neutron generators, two special and novel Beam Shaping Assemblies (BSA), including multi-layer and hexagonal lattice have been suggested and the effect of them has been investigated by MCNP4C Monte Carlo code. The results show that the proposed BSA can provide the qualified epithermal neutron beam for BNCT. The final epithermal neutron flux is about 6e9 n/cm2.s. The final proposed BSA has some different advantages: 1) it consists of usual and well-known materials (Pb, Al, Fluental and Cd); 2) it has a simple geometry; 3) it does not need any additional gamma filter; 4) it can provide high flux of epithermal neutrons. As this type of neutron source is under development in the world, it seems that they can be used clinically in a hospital considering the proposed BSA.

  5. Gel dosimeters as useful dose and thermal-fluence detectors in Boron Neutron Capture Therapy (BNCT)

    Energy Technology Data Exchange (ETDEWEB)

    Gambarini, G.; Valente, M. [Department of Physics of the University and INFN, Via Celoria 16, I-20133 Milan (Italy); Moss, R.L.; Daquino, G.G.; Nievaart, V.A. [Joint Research Centre, Institute for Energy, P.O. Box 2, NL-1755ZG Petten, The Netherlands (Netherlands); Mariani, M.; Vanossi, E. [Department of Nuclear Engineering of Polytechnic, CESNEF, Via Ponzio, 34/3 - I-20133 Milan (Italy); Carrara, M. [Medical Physics Department, National Cancer Institute, Via Venezian 1, I-20131, Milan (Italy)

    2006-07-01

    The dosimetry method based on Fricke-Xylenol-Orange-infused gels in form of layers has shown noticeable potentiality for in-phantom or in-free-beam dose and thermal flux profiling and imaging in the high fluxes of thermal or epithermal neutrons utilised for boron neutron capture therapy (BNCT). Gel-dosimeters in form of layers give the possibility not only of obtaining spatial dose distributions but also of achieving measurements of each dose contribution in neutron fields. The discrimination of the various dose components is achieved by means of pixel-to-pixel manipulations of pairs of images obtained with gel-dosimeters having different isotopic composition. It is possible to place large dosimeters, detecting in such a way large dose images, because the layer geometry of dosimeters avoids sensitive variation of neutron transport due to the gel isotopic composition. Some results obtained after the last improvements of the method are reported. (Author)

  6. Neutron spectra measurement and comparison of the HFR and THOR BNCT beams.

    Science.gov (United States)

    Liu, Yuan-Hao; Nievaart, Sander; Tsai, Pi-En; Liu, Hong-Ming; Moss, Ray; Jiang, Shiang-Huei

    2009-07-01

    This paper aims to measure the spectra of HB11 (high flux reactor, HFR) and the Tsing Hua open-pool reactor (THOR) boron neutron capture therapy (BNCT) beams by multiple activation foils. The self-shielding corrections were made with the aid of MCNP calculations. The initial spectra were adjusted by a sophisticated process named coarse-scaling adjustment using SAND-EX, which can adjust a given coarse-group spectrum into a fine-group structure, i.e. 640 groups, with excellent continuity. The epithermal neutron flux of the THOR beam is about three times of HB11. The thermal neutron flux, boron and gold reaction rates along the central axis of a PMMA phantom are calculated for both adjusted spectra for comparison.

  7. Synthesis of optically active dodecaborate-containing L-amino acids for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Kusaka, Shintaro [Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai (Japan); Hattori, Yoshihide, E-mail: y0shi_hattori@riast.osakafu-u.ac.jp [Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai (Japan); Uehara, Kouki; Asano, Tomoyuki [Stella Pharma Corporation, ORIX Kouraibashi Bldg. 5F 3-2-7 Kouraibashi, Chuo-ku, Osaka (Japan); Tanimori, Shinji; Kirihata, Mitsunori [Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai (Japan)

    2011-12-15

    A convenient and simple synthetic method of dodecaboratethio-L-amino acid, a new class of tumor-seeking boron carrier for BNCT, was accomplished from S-cyanoethylthioundecahydro-closo-dodecaborate (S-cyanoethyl-{sup 10}BSH, [{sup 10}B{sub 12}H{sub 11}]{sup 2-}SCH{sub 2}CH{sub 2}CN) and bromo-L-{alpha}-amino acids by nearly one step S-alkylation. An improved synthesis of S-cyanoethyl-{sup 10}BSH, a key starting compound for S-alkylation, was also performed by Michael addition of {sup 10}BSH with acryronitrile in high yield. Four kinds of new dodecaboratethio-L-amino acids were obtained in optically pure form without the need for any optical resolution.

  8. Laboratory Directed Research and Development Program Activities for FY 2008.

    Energy Technology Data Exchange (ETDEWEB)

    Looney,J.P.; Fox, K.

    2009-04-01

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that maintains a primary mission focus the physical sciences, energy sciences, and life sciences, with additional expertise in environmental sciences, energy technologies, and national security. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal year 2008 budget was $531.6 million. There are about 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Developlnent at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. Accordingly, this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2008. BNL expended $12 million during Fiscal Year 2008 in support of 69 projects. The program has two categories, the annual Open Call LDRDs and Strategic LDRDs, which combine to meet the overall objectives of the LDRD Program. Proposals are solicited annually for review and approval concurrent with the next fiscal year, October 1. For the open call for proposals, an LDRD Selection Committee, comprised of the Associate Laboratory Directors (ALDs) for the Scientific Directorates, an equal number of scientists recommended by the Brookhaven Council, plus the Assistant Laboratory Director for Policy and Strategic Planning, review the proposals submitted in response to the solicitation. The Open Can LDRD category emphasizes innovative research concepts

  9. Laboratory Directed Research and Development Program Activities for FY 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Newman,L.

    2007-12-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal year 2007 budget was $515 million. There are about 2,600 employees, and another 4,500 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development', April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. In accordance this is our Annual Report in which we describe the Purpose, Approach, Technical Progress and Results, and Specific Accomplishments of all LDRD projects that received funding during Fiscal Year 2007. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. We explicitly indicate that research conducted under the LDRD Program should be highly innovative, and an element of high risk as to success is acceptable. In the solicitation for new proposals for Fiscal Year 2007 we especially requested innovative new projects in

  10. US Global Change Research Program Distributed Cost Budget Interagency Funds Transfer from DOE to NSF

    Energy Technology Data Exchange (ETDEWEB)

    Uhle, Maria [National Science Foundation (NSF), Washington, DC (United States)

    2016-09-22

    These funds were transferred from DOE to NSF as DOE's contribution to the U.S. Global Change Research Program in support of 4 internationalnactivities/programs as approved by the U.S. Global Change Research Program on 14 March 2014. The programs are the International Geosphere-Biosphere Programme, the DIVERSITAS programme, and the World Climate Research Program. All program awards ended as of 09-23-2015.

  11. Confirmation of a realistic reactor model for BNCT dosimetry at the TRIGA Mainz

    Energy Technology Data Exchange (ETDEWEB)

    Ziegner, Markus, E-mail: Markus.Ziegner.fl@ait.ac.at [AIT Austrian Institute of Technology GmbH, Vienna A-1220, Austria and Institute of Atomic and Subatomic Physics, Vienna University of Technology, Vienna A-1020 (Austria); Schmitz, Tobias; Hampel, Gabriele [Institut für Kernchemie, Johannes Gutenberg-Universität, Mainz DE-55128 (Germany); Khan, Rustam [Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad PK-44000 (Pakistan); Blaickner, Matthias [AIT Austrian Institute of Technology GmbH, Vienna A-1220 (Austria); Palmans, Hugo [Acoustics and Ionising Radiation Division, National Physical Laboratory, Teddington TW11 0LW, United Kingdom and Medical Physics Group, EBG MedAustron GmbH, Wiener Neustadt A-2700 (Austria); Sharpe, Peter [Acoustics and Ionising Radiation Division, National Physical Laboratory, Teddington TW11 0LW (United Kingdom); Böck, Helmuth [Institute of Atomic and Subatomic Physics, Vienna University of Technology, Vienna A-1020 (Austria)

    2014-11-01

    Purpose: In order to build up a reliable dose monitoring system for boron neutron capture therapy (BNCT) applications at the TRIGA reactor in Mainz, a computer model for the entire reactor was established, simulating the radiation field by means of the Monte Carlo method. The impact of different source definition techniques was compared and the model was validated by experimental fluence and dose determinations. Methods: The depletion calculation code ORIGEN2 was used to compute the burn-up and relevant material composition of each burned fuel element from the day of first reactor operation to its current core. The material composition of the current core was used in a MCNP5 model of the initial core developed earlier. To perform calculations for the region outside the reactor core, the model was expanded to include the thermal column and compared with the previously established ATTILA model. Subsequently, the computational model is simplified in order to reduce the calculation time. Both simulation models are validated by experiments with different setups using alanine dosimetry and gold activation measurements with two different types of phantoms. Results: The MCNP5 simulated neutron spectrum and source strength are found to be in good agreement with the previous ATTILA model whereas the photon production is much lower. Both MCNP5 simulation models predict all experimental dose values with an accuracy of about 5%. The simulations reveal that a Teflon environment favorably reduces the gamma dose component as compared to a polymethyl methacrylate phantom. Conclusions: A computer model for BNCT dosimetry was established, allowing the prediction of dosimetric quantities without further calibration and within a reasonable computation time for clinical applications. The good agreement between the MCNP5 simulations and experiments demonstrates that the ATTILA model overestimates the gamma dose contribution. The detailed model can be used for the planning of structural

  12. Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.

    Science.gov (United States)

    Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O

    2015-12-01

    BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source.

  13. Federal Geothermal Research Program Update - Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Laney

    2005-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermal electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently possible or

  14. Federal Geothermal Research Program Update Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    2005-03-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermal electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently

  15. Laboratory directed research and development program FY 2003

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd

    2004-03-27

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. In FY03, Berkeley Lab was authorized by DOE to establish a funding ceiling for the LDRD program of $15.0 M, which equates to about 3.2% of Berkeley Lab's FY03 projected operating and capital equipment budgets. This funding level was provided to develop new scientific ideas and opportunities and allow the Berkeley Lab Director an opportunity to initiate new directions. Budget constraints limited available resources, however, so only $10.1 M was expended for operating and $0.6 M for capital equipment (2.4% of actual Berkeley Lab FY03 costs). In FY03, scientists submitted 168 proposals, requesting over $24.2 M in operating funding. Eighty-two projects were funded, with awards ranging from $45 K to $500 K. These projects are summarized in Table 1.

  16. Energy Efficient Industrialized Housing Research Program. Annual report, FY 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    Six area reported progress in the Energy Efficient Industrialized Housing Research Program during FY 1991. As part of Industry Guidance, meetings were held with steering and technical committees in computers, housing design and manufacturing. This task area enables the program to benefit from the expertise of industry representatives and communicate research results directly to them. As part of the Design Process performance specifications were being developed for the future housing system designed last year. These house designs coordinate and optimize predicted and desirable advances in computerized design processes, materials, components, and manufacturing automation to achieve energy efficiency at reduced first cost. Energy design software were being developed for CAD systems, stressed skin insulating core panel manufacturers; and a prototype energy sales tool. A prototype design was to be developed to integrate one or more subsystems with the building skin. As part of the Manufacturing Process we are developing a manufacturing process simulation and data base to help current and new entrants to the industrialized housing industry in assessing the impact of implementing new manufacturing techniques. For Evaluation we are developing testing plans for six units of housing on the UO campus and the stressed skin insulating core house to be constructed in Oregon. The DOW Chemical test structure will be retrofitted with a tile roof and retested to compare to the dome and conventional construction structures. Calibration of the wind tunnel will be completed so that laboratory tests can be conducted to simulate the ventilation cooling efficiency of houses in design. Research utilization and program management were either aspects of this program.

  17. A networked research program for aluminum production and transformation

    Science.gov (United States)

    Bui, R. T.; Charette, A.; Fafard, M.; Paray, F.; Soucy, G.; Ajersch, F.; Masounave, J.; Chiesa, F.

    2003-05-01

    In response to increasing needs and new opportunities, a provincewide network of Quebec institutions of higher learning, R&D agencies, and technology users has been set up to carry out research in aluminum production, fabrication, and transformation technologies, and to help channel the expertise and resources into large projects with more efficiency in terms of generating synergy and funding, cutting-edge research, qualified personnel training, and technology transfers. It is a unique experience in collaborative, multipartite, university-based R&D which, in addition to a comprehensive, far-reaching research program, emphasizes the various aspects of dispersed inter-institutional coordination, resource sharing, synergy creation, joint graduate training, diversification of funding, and intellectual property.

  18. Video Use in Social Science Research and Program Evaluation

    Directory of Open Access Journals (Sweden)

    Barbara Rosenstein

    2002-09-01

    Full Text Available In light of technological advances in producing, viewing and storing moving images, it is appropriate to survey the literature concerning the use of moving images in research over the past few decades. A review of the literature shows that the use of video technology for research falls into three areas: observation (including data collection and analysis, a mechanism for giving feedback, and a means for distance learning and consulting via videoconferencing. This article addresses the first two areas — observation and feedback. It begins with a survey of the use of video observation as a tool for research and documentation. A section on feedback, divided into three sections: performance, interaction and situational assessment follows. A separate section is devoted to the use of video for Program Evaluation. The article concludes with a discussion of epistemological methodological issues and the ethics involved in such a technologically advanced medium.

  19. Italia-Netherland PhD Program: the I.O. PhD Research Program.

    Science.gov (United States)

    Bellissima, Valentina; Borghesi, Alessandro; Bozzetti, Valentina; Dessì, Angelica; Fabiano, Adele; Risso, Francesco M; Salvo, Vincenzo; Satriano, Angela; Silvagni, Davide; Varrica, Alessandro; van Bel, Frank; Visser, Gerard H A; Vles, Hans Js; Zimmermann, Luc J I; Gavilanes, Antonio D W; Gazzolo, Diego

    2011-10-01

    In the framework of long-term scientific collaboration among the founder members coming from Holland and Italy there was a growing consensus to activate a philosophical doctorate (PhD) program, involving young Italian researchers in the field of perinatal medicine, neonatology and pediatrics. The aims were to promote excellence in research, offering to young Italian physicians the opportunity to maturate an International research experience leading to PhD degree, and to promote human and technological improvement energies in perinatal, neonatal and pediatrics research. Thus, an official collaboration among the Dutch Universities from Maastricht and Utrecht and the Italian Children's Hospital from Alessandria, has been activated on March 1st 2010, finalized to the PhD program. The experimental phase included the selection of projects and relative candidates after an interview-selection focusing on their scientific attitudes and the availability on their research projects. Candidates' selection started on May 2010 and on September 29th ten projects and candidates have been approved by the scientific commission. Research topics included: perinatal asphyxia, aging and the origin of adulthood neurodegenerative disease, neuroprotective strategies, biochemical pulmonology, intrauterine growth retardation and perinatal teratology. To date, all projects have been approved by local Ethics Committee from the University/Hospital of origin of the candidates. Five manuscripts have been published and/or submitted to international Journals regarding pneumology, perinatal asphyxia and teratology, whilst about 60-70% of data regarding clinical studies have already been collected.

  20. 77 FR 40596 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-07-10

    ... Rehabilitation Research Projects and Centers program published in the Federal Register on April 28, 2006 (71 FR... Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program; Disability... Rehabilitation Research Projects and Centers Program-- Disability and Rehabilitation Research Projects...

  1. Technology Roadmap Research Program for the Steel Industry

    Energy Technology Data Exchange (ETDEWEB)

    Joseph R. Vehec

    2010-12-30

    The steel industry's Technology Roadmap Program (TRP) is a collaborative R&D effort jointly sponsored by the steel industry and the United States Department of Energy. The TRP program was designed to develop new technologies to save energy , increase competitiveness, and improve the environment. TRP ran from July, 1997 to December, 2008, with a total program budget of $38 million dollars. During that period 47 R&D projects were performed by 28 unique research organizations; co-funding was provided by DOE and 60 industry partners. The projects benefited all areas of steelmaking and much know-how was developed and transferred to industry. The American Iron and Steel Institute is the owner of all intellectual property developed under TRP and licenses it at commercial rates to all steelmakers. TRP technologies are in widespread use in the steel industry as participants received royalty-free use of intellectual property in return for taking the risk of funding this research.

  2. Overview of recent activities in the Heat Cycle Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Bliem, C.J.; Mines, G.L.

    1987-01-01

    The Heat Cycle Research Program, which is being conducted for the Department of Energy, has as its objective the development of the technology for effecting the improved utilization of moderate temperature geothermal resources. To meet this objective, the program has as one of its goals to improve the performance of geothermal binary cycles to levels approaching the practicable thermodynamic maximum. In pursuit of this goal, tests are being conducted at the Heat Cycle Research Facility located at the DOE Geothermal Test Facility, East Mesa, California. The current testing involves the investigation of binary power cycle performance utilizing mixtures of non-adjacent hydrocarbons as the working fluids, with supercritical vaporization and in-tube condensation of the working fluid. In addition to the present test program, preparations are being made to investigate the binary cycle performance improvements which can be achieved by allowing supersaturated vapor expansions in the turbine. These efforts are anticipated to verify that through the utilization of these advanced power cycle concepts and allowing the supersaturated turbine expansions, improvements of up to 28% in the net geofluid effectiveness (net watt hours plant output per pound of geofluid) over conventional binary power plants can be achieved. Results presented for the recent testing, including those tests examining the performance of the countercurrent condenser at different tube inclinations, support the assumptions used in projected performance improvements. 3 refs., 9 figs.

  3. Moving research into practice: lessons from the US Agency for Healthcare Research and Quality's IDSRN program

    Directory of Open Access Journals (Sweden)

    Taylor Erin

    2007-03-01

    Full Text Available Abstract Background The U.S. Agency for Healthcare Research and Quality's (AHRQ Integrated Delivery Systems Research Network (IDSRN program was established to foster public-private collaboration between health services researchers and health care delivery systems. Its broad goal was to link researchers and delivery systems to encourage implementation of research into practice. We evaluated the program to address two primary questions: 1 How successful was IDSRN in generating research findings that could be applied in practice? and 2 What factors facilitate or impede such success? Methods We conducted in-person and telephone interviews with AHRQ staff and nine IDSRN partner organizations and their collaborators, reviewed program documents, analyzed projects funded through the program, and developed case studies of four IDSRN projects judged promising in supporting research implementation. Results Participants reported that the IDSRN structure was valuable in creating closer ties between researchers and participating health systems. Of the 50 completed projects studied, 30 had an operational effect or use. Some kinds of projects were more successful than others in influencing operations. If certain conditions were met, a variety of partnership models successfully supported implementation. An internal champion was necessary for partnerships involving researchers based outside the delivery system. Case studies identified several factors important to success: responsiveness of project work to delivery system needs, ongoing funding to support multiple project phases, and development of applied products or tools that helped users see their operational relevance. Factors limiting success included limited project funding, competing demands on potential research users, and failure to reach the appropriate audience. Conclusion Forging stronger partnerships between researchers and delivery systems has the potential to make research more relevant to users

  4. Lessons in collaboration and effective field research from the Appalachian Headwaters Research Experience for Undergraduates Program

    Science.gov (United States)

    Jones, A. L.; Fox, J.; Wilder, M. S.

    2009-12-01

    In the summer of 2009, the authors launched year one of a three-year National Science Foundation-funded Research Experience for Undergraduates entitled "Carbon Storage and Headwater Health in the Appalachian Headwaters." Eight undergraduates selected from a nationally competitive field of more than 60 applicants participated in the ten-week field- and laboratory-based program along with three middle- and high-school teachers. Each student developed and completed an independent research project related to coal mining’s impact on soil organic carbon and sediment transport processes. Specifically, they used isotope ratio mass spectrometry to measure the carbon and nitrogen stable isotopic signature of soils and sediments in the Appalachian headwater landscapes and first order streams of Kentucky's southeastern coalfields. Among the program's innovative features was its fundamentally collaborative nature--which was represented in several ways. First, the background of the three program leaders was very different: an environmental planner with an academic background in land use planning and administration (Jones); a civil engineer trained in biogeochemistry and watershed modeling (Fox); and an environmental educator experienced in both formal and nonformal educator training and certification (Wilder). The program was also a collaboration between a Carnegie 1 research-oriented institution and an undergraduate/ teaching -focused regional comprehensive university. Finally, the participants themselves represented a diversity of disciplines and institutional backgrounds--including biology, geology, chemistry, environmental science and civil engineering. The Research Experience for Teachers component was another innovative program element. The teachers participated in all field and laboratory research activities during the first six weeks, then developed a unit of study for their own classrooms to be implemented during the current school year. In addition to the six

  5. Measurements of gamma dose and thermal neutron fluence in phantoms exposed to a BNCT epithermal beam with TLD-700.

    Science.gov (United States)

    Gambarini, G; Magni, D; Regazzoni, V; Borroni, M; Carrara, M; Pignoli, E; Burian, J; Marek, M; Klupak, V; Viererbl, L

    2014-10-01

    Gamma dose and thermal neutron fluence in a phantom exposed to an epithermal neutron beam for boron neutron capture therapy (BNCT) can be measured by means of a single thermoluminescence dosemeter (TLD-700). The method exploits the shape of the glow curve (GC) and requires the gamma-calibration GC (to obtain gamma dose) and the thermal-neutron-calibration GC (to obtain neutron fluence). The method is applicable for BNCT dosimetry in case of epithermal neutron beams from a reactor because, in most irradiation configurations, thermal neutrons give a not negligible contribution to the TLD-700 GC. The thermal neutron calibration is not simple, because of the impossibility of having thermal neutron fields without gamma contamination, but a calibration method is here proposed, strictly bound to the method itself of dose separation.

  6. Microdosimetric evaluation of the neutron field for BNCT at Kyoto University reactor by using the PHITS code.

    Science.gov (United States)

    Baba, H; Onizuka, Y; Nakao, M; Fukahori, M; Sato, T; Sakurai, Y; Tanaka, H; Endo, S

    2011-02-01

    In this study, microdosimetric energy distributions of secondary charged particles from the (10)B(n,α)(7)Li reaction in boron-neutron capture therapy (BNCT) field were calculated using the Particle and Heavy Ion Transport code System (PHITS). The PHITS simulation was performed to reproduce the geometrical set-up of an experiment that measured the microdosimetric energy distributions at the Kyoto University Reactor where two types of tissue-equivalent proportional counters were used, one with A-150 wall alone and another with a 50-ppm-boron-loaded A-150 wall. It was found that the PHITS code is a useful tool for the simulation of the energy deposited in tissue in BNCT based on the comparisons with experimental results.

  7. Feasibility of sealed D-T neutron generator as neutron source for liver BNCT and its beam shaping assembly.

    Science.gov (United States)

    Liu, Zheng; Li, Gang; Liu, Linmao

    2014-04-01

    This paper involves the feasibility of boron neutron capture therapy (BNCT) for liver tumor with four sealed neutron generators as neutron source. Two generators are placed on each side of the liver. The high energy of these emitted neutrons should be reduced by designing a beam shaping assembly (BSA) to make them useable for BNCT. However, the neutron flux decreases as neutrons pass through different materials of BSA. Therefore, it is essential to find ways to increase the neutron flux. In this paper, the feasibility of using low enrichment uranium as a neutron multiplier is investigated to increase the number of neutrons emitted from D-T neutron generators. The neutron spectrum related to our system has a proper epithermal flux, and the fast and thermal neutron fluxes comply with the IAEA recommended values.

  8. How to Successfully Incorporate Undergraduate Researchers Into a Complex Research Program at a Large Institution.

    Science.gov (United States)

    Weldon, Rebecca B; Reyna, Valerie F

    2015-01-01

    One feature of the Laboratory for Rational Decision Making at Cornell University is the integration of a large number of undergraduate students into a relatively elaborate research program. We describe our thorough screening process, laboratory structure, and our expectations for undergraduate researchers in our lab. We have a structure in place that helps maintain organization and enhance productivity, including scheduled weekly and monthly meetings, and selecting undergraduate and graduate team leaders to lead each research project. We discuss how it is important to encourage students to aim high and have a good attitude toward learning and problem solving. We emphasize that both initiative and teamwork are important in a large research laboratory. We also discuss the importance of giving students responsibility in connection with research projects-our undergraduate researchers engage in data analysis, interpretation of results, and have a high-level understanding of theory.

  9. AB-BNCT beam shaping assembly based on {sup 7}Li(p,n){sup 7}Be reaction optimization

    Energy Technology Data Exchange (ETDEWEB)

    Minsky, D.M., E-mail: minsky@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral Paz 1499 (B1650KNA), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. de Irigoyen 3100 (1650), San Martin (Argentina)] [CONICET, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral Paz 1499 (B1650KNA), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. de Irigoyen 3100 (1650), San Martin (Argentina)] [CONICET, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CNEA, Av. Gral Paz 1499 (B1650KNA), San Martin, Buenos Aires (Argentina)] [Escuela de Ciencia y Tecnologia, UNSAM, M. de Irigoyen 3100 (1650), San Martin (Argentina)

    2011-12-15

    A numerical optimization of a Beam Shaping Assembly (BSA) for Accelerator Based-Boron Neutron Capture Therapy (AB-BNCT) has been performed. The reaction {sup 7}Li(p,n){sup 7}Be has been considered using a proton beam on a lithium fluoride target. Proton energy and the dimensions of a simple BSA geometry have been varied to obtain a set of different configurations. The optimal configuration of this set is shown.

  10. Governmental Research Support Programs and Private Entities in Slovakia

    Directory of Open Access Journals (Sweden)

    Maliková Zuzana

    2015-01-01

    Full Text Available The paper analyses public subsidies aimed to enhance development and innovation in the Slovakian private sector. The paper reviews theoretical approaches of the necessity of public support to research and development activities in order to increase private investment in research and development. An overview of research and development support tools in Slovakia is presented. The analytical part of the work is oriented on a comparative analysis of two granting agencies in Slovakia [Agency for Research and Development (ARD and Agency of Operational Program Research and Development (OPRD]. Special attention is given to direct public financial support. Logit analysis showed a relationship between success of grant applicants and their characteristics. We find that the following have impact on success of the application: Age of the company, amount of the grant required, legal form of the company, and the agency to which the application for grant was submitted. Applicants with legal form Ltd. (limited liability company have a higher chance of receiving grant than other legal forms. The highest chance of success has a request for a grant of up to 500.000 €. According to the results of our analysis, the chance to obtain a grant decreases with each passing year.

  11. United States Air Force Summer Faculty Research Program 1989. Program Technical Report. Volume 3

    Science.gov (United States)

    1989-12-01

    34, Signal ProceSsing (to appear) 3. John 14:6 4. Orwell , George , Animal Farm. 99-20 1989 USAF-UES SUMMER FACULTY RESEARCH PROGRAM Sponsored by the AIR...FL 32901 407\\984-5689 George Coleman Degree: MS Instructor Specialty: Applied Mathematics Elizabeth City St. University Assigned: Armament Laboratory...Federal St. Chicago, IL 60616 312\\567-3405 George Veyera Degree: PhD Assistant Prof. Specialty: Civil Eng. Rhode Island, University of Assigned

  12. Transportable Heavy Duty Emissions Testing Laboratory and Research Program

    Energy Technology Data Exchange (ETDEWEB)

    David Lyons

    2008-03-31

    The objective of this program was to quantify the emissions from heavy-duty vehicles operating on alternative fuels or advanced fuel blends, often with novel engine technology or aftertreatment. In the first year of the program West Virginia University (WVU) researchers determined that a transportable chassis dynamometer emissions measurement approach was required so that fleets of trucks and buses did not need to be ferried across the nation to a fixed facility. A Transportable Heavy-Duty Vehicle Emissions Testing Laboratory (Translab) was designed, constructed and verified. This laboratory consisted of a chassis dynamometer semi-trailer and an analytic trailer housing a full scale exhaust dilution tunnel and sampling system which mimicked closely the system described in the Code of Federal Regulations for engine certification. The Translab was first used to quantify emissions from natural gas and methanol fueled transit buses, and a second Translab unit was constructed to satisfy research demand. Subsequent emissions measurement was performed on trucks and buses using ethanol, Fischer-Tropsch fuel, and biodiesel. A medium-duty chassis dynamometer was also designed and constructed to facilitate research on delivery vehicles in the 10,000 to 20,000lb range. The Translab participated in major programs to evaluate low-sulfur diesel in conjunction with passively regenerating exhaust particulate filtration technology, and substantial reductions in particulate matter were recorded. The researchers also participated in programs to evaluate emissions from advanced natural gas engines with closed loop feedback control. These natural gas engines showed substantially reduced levels of oxides of nitrogen. For all of the trucks and buses characterized, the levels of carbon monoxide, oxides of nitrogen, hydrocarbons, carbon dioxide and particulate matter were quantified, and in many cases non-regulated species such as aldehydes were also sampled. Particle size was also

  13. University of Utah Oil Sand Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Oblad, A.G.; Bunger, J.W.; Dahlstrom, D.A.; Deo, M.D.; Fletcher, J.V.; Hanson, F.V.; Miller, J.D.; Seader, J.D.

    1993-12-31

    An overview of the Oil Sand Research and Development Program at the University of Utah will be presented. It will include resource characterization of the Uinta Basin oils and deposits and bitumens and bitumen-derived liquid recovery and upgrading technology and product utilization. The characterization studies will include the Whiterocks and Asphalt Ridge oil sands. The discussion of recovery and upgrading technologies will include aqueous separation, thermal recovery processes; solvent extraction, and thermal and catalytic upgrading of bitumen and bitumen-derived heavy oils. Product evaluation studies will include jet fuels, diesel fuel, asphalt and specialty chemicals. Plans for the future of the project will be discussed.

  14. Research Program towards Observation of Neutrino-Nucleus Coherent Scattering

    CERN Document Server

    Wong, H T

    2006-01-01

    The article describes the research program pursued by the TEXONO Collaboration towards an experiment to observe coherent scattering between neutrinos and the nucleus at the power reactor. The motivations of studying this process are surveyed. In particular, a threshold of 100-200 eV has been achieved with an ultra-low-energy germanium detector prototype. This detection capability at low energy can also be adapted to conduct searches of Cold Dark Matter in the low-mass region as well as to enhance the sensitivities in the study of neutrino magnetic moments.

  15. Laboratory Directed Research and Development Program. FY 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory`s core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology. (GHH)

  16. Subsystem fragility: Seismic Safety Margins Research Program (Phase I)

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, R. P.; Campbell, R. D.; Hardy, G.; Banon, H.

    1981-10-01

    Seismic fragility levels of safety related equipment are developed for use in a seismic oriented Probabilistic Risk Assessment (PRA) being conducted as part of the Seismic Safety Margins Research Program (SSMRP). The Zion Nuclear Power Plant is being utilized as a reference plant and fragility descriptions are developed for specific and generic safety related equipment groups in Zion. Both equipment fragilities and equipment responses are defined in probabilistic terms to be used as input to the SSMRP event tree/fault tree models of the Zion systems. 65 refs., 14 figs., 11 tabs.

  17. Considerations for boron neutron capture therapy studies; Consideracoes sobre o estudo da BNCT (terapia de captura neutronica por boro)

    Energy Technology Data Exchange (ETDEWEB)

    Faria Gaspar, P. de

    1994-12-31

    Radiotherapy is indispensable as a mean to eradicate deeply or infiltrating tumor tissue that can not be removed surgically. Therefore, it is not selective and may also kill the surrounding health tissue. The principle of BNCT (Boron Neutron Capture Therapy) consist in targeting a tumor selectively with a boron-10 compound. This nuclide has a large capture cross section for thermal neutrons and the nuclear reaction and the delivered energy in locus will selective the tumor. Since its initial proposal in 1963 BNCT has made much progress, however it is not used in a routine treatment. In this work it was approached some complex procedures, as the obtention of selective boron compounds, the adequate set up of neutron beams, the biodistribution, the in vivo and in vitro studies, and also human patients treatments. This work provide fundamentals about BNCT to professional of different areas of knowledge since it comprises multidisciplinary study. It includes appendixes for the ones not related to the field for a better comprehension of the many aspects involved. It is also presented a glossary containing technical and basic aspects involved. It is also presented a glossary containing technical and basic terms referred in the work. (author). 174 refs, 1 fig, 12 apps.

  18. Hawaii Student / Teacher Astronomy Research (HI STAR) Program

    Science.gov (United States)

    Nassir, Michael A.; Kadooka, M.

    2007-05-01

    How do we encourage more students to pursue science, technology, engineering and mathematics (STEM) careers? We are using astronomy to engage rural, at-risk and/or Native Hawaiian students living on other islands with a passion for science. Our workshops on Molokai, Maui, and the Big Island of Hawaii have been unique by including both students and teachers as learners. Participants, as young as 5th-graders, are exposed to the physics principles underlying basic astronomy concepts, including laws of motion, gravitation, orbits, optics, and the EM spectrum. The workshop builds toward research skills such as blink-comparison, astrometry, and photometry of CCD images using commercially available software. Ultimately, students and teachers have an opportunity to use the professional grade 2.0-m LCOGT telescope located atop Haleakala on Maui for observational research. Lessons learned and future plans for a 2007 summer workshop will be shared. This program is supported by a NASA IDEAS EPO Grant.

  19. Programming Cloud Resource Orchestration Framework: Operations and Research Challenges

    CERN Document Server

    Ranjan, Rajiv

    2012-01-01

    The emergence of cloud computing over the past five years is potentially one of the breakthrough advances in the history of computing. It delivers hardware and software resources as virtualization-enabled services and in which administrators are free from the burden of worrying about the low level implementation or system administration details. Although cloud computing offers considerable opportunities for the users (e.g. application developers, governments, new startups, administrators, consultants, scientists, business analyst, etc.) such as no up-front investment, lowering operating cost, and infinite scalability, it has many unique research challenges that need to be carefully addressed in the future. In this paper, we present a survey on key cloud computing concepts, resource abstractions, and programming operations for orchestrating resources and associated research challenges, wherever applicable.

  20. Water Resources Research Grant Program project descriptions, fiscal year 1986

    Science.gov (United States)

    ,

    1986-01-01

    Information is presented on the 43 projects funded by the United States Geological Survey 's Water Resources Grant Program in fiscal year 1986. The report gives the grant number; project title; performing organization; principal investigator(s); dates; and a project description which includes (1) identification of the water related problems and problem-solution approach, (2) contribution to problem solution, (3) objectives, (4) approach, and (5) result users. The 43 projects include 14 in the area of groundwater management, 6 in surface-water management, 2 in systems-operating/planning, 3 in irrigation management, 8 in desalination/reuse, 6 in economic/institutional studies, and 4 in climate variability. The reports contain tables showing (1) funding according to research topic, (2) projects funded to type of submitting organization, (3) proposals received, research topic, and funding levels, and (4) submitting organization. A comparison is given to fiscal year 1985 in each case. (USGS)

  1. 75 FR 27789 - Proposed Collection; Comment Request; Application for the Pharmacology Research Associate Program

    Science.gov (United States)

    2010-05-18

    ... Collection; Comment Request; Application for the Pharmacology Research Associate Program SUMMARY: In... projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed Collection: Title: Application for the Pharmacology Research Associate Program. Type of...

  2. 10 CFR 605.5 - The Office of Energy Research Financial Assistance Program.

    Science.gov (United States)

    2010-01-01

    ... Program. (a) DOE may issue, under the Office of Energy Research Financial Assistance Program, 10 CFR part... Management (3) Fusion Energy (4) Health and Environmental Research (5) High Energy and Nuclear Physics...

  3. A New Approach to Commercialization of NASA's Human Research Program Technologies Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I SBIR proposal describes, "A New Approach to Commercialization of NASA's Human Research Program Technologies." NASA has a powerful research...

  4. EURATOM VI Framework Research and Training Program; VI Programa Marco de Investigacion y Formacion de Euratom

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, A.; Brincones, M.; Calvo, J. F.; Butrageno, J. L.

    2002-07-01

    Under the Euratom Treaty, research is implemented in the EU through multi-annual research programs called framework programs. last June, the European Council approved the Sixth Euratom Framework Program (2002-2006), drawn up in consultation with specialists from the Nuclear Security Council. The new program. (Author)

  5. Research Problems in Data Curation: Outcomes from the Data Curation Education in Research Centers Program

    Science.gov (United States)

    Palmer, C. L.; Mayernik, M. S.; Weber, N.; Baker, K. S.; Kelly, K.; Marlino, M. R.; Thompson, C. A.

    2013-12-01

    The need for data curation is being recognized in numerous institutional settings as national research funding agencies extend data archiving mandates to cover more types of research grants. Data curation, however, is not only a practical challenge. It presents many conceptual and theoretical challenges that must be investigated to design appropriate technical systems, social practices and institutions, policies, and services. This presentation reports on outcomes from an investigation of research problems in data curation conducted as part of the Data Curation Education in Research Centers (DCERC) program. DCERC is developing a new model for educating data professionals to contribute to scientific research. The program is organized around foundational courses and field experiences in research and data centers for both master's and doctoral students. The initiative is led by the Graduate School of Library and Information Science at the University of Illinois at Urbana-Champaign, in collaboration with the School of Information Sciences at the University of Tennessee, and library and data professionals at the National Center for Atmospheric Research (NCAR). At the doctoral level DCERC is educating future faculty and researchers in data curation and establishing a research agenda to advance the field. The doctoral seminar, Research Problems in Data Curation, was developed and taught in 2012 by the DCERC principal investigator and two doctoral fellows at the University of Illinois. It was designed to define the problem space of data curation, examine relevant concepts and theories related to both technical and social perspectives, and articulate research questions that are either unexplored or under theorized in the current literature. There was a particular emphasis on the Earth and environmental sciences, with guest speakers brought in from NCAR, National Snow and Ice Data Center (NSIDC), and Rensselaer Polytechnic Institute. Through the assignments, students

  6. Role of research reactors for nuclear power program in Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Soentono, S.; Arbie, B. [National Atomic Energy Agency, Batan (Indonesia)

    1994-12-31

    The main objectives of nuclear development program in Indonesia are to master nuclear science and technology, as well as to utilise peaceful uses of nuclear know-how, aiming at stepwisely socioeconomic development. A Triga Mark II, previously of 250 kW, reactor in Bandung has been in operation since 1965 and its design power has been increased to 1000 kW in 1972. Using core grid of the Triga 250 kW, BATAN designed and constructed the Kartini Reactor in Yogyakarta which started its operation in 1979. Both of these Triga reactors have served a wide spectrum of utilisation, such as training of manpower in nuclear engineering as well as radiochemistry, isotope production and beam research activities in solid state physics. In order to support the nuclear power development program in general and to suffice the reactor experiments further, simultaneously meeting the ever increasing demand for radioisotope, the third reactor, a multipurpose reactor of 30 MW called GA. Siwabessy (RSG-GAS) has been in operation since 1987 at Serpong near Jakarta. Each of these reactors has strong cooperation with Universities, namely the Bandung Institute of Technology at Bandung, the Gadjah Mada University at Yogyakarta, and the Indonesia University at Jakarta and has facilitated the man power development required. The role of these reactors, especially the multipurpose GA. Siwabessy reactor, as essential tools in nuclear power program are described including the experience gained during preproject, construction and commissioning, as well as through their operation, maintenance and utilisation.

  7. What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?

    Science.gov (United States)

    Allen, D A; Beynon, T D

    2000-05-01

    With a growing interest in the use of accelerator-based epithermal neutron sources for BNCT programs, in particular those based upon the 7Li(p,n)7Be reaction, there is a need to address the question of "what is the best proton energy to use?" This paper considers this question by using radiation transport calculations to investigate a range of proton energies from 2.15 to 3.5 MeV and a range of moderator sizes. This study has moved away completely from the use of empty therapy beam parameters and instead defines the beam quality and optimizes the moderator design using widely accepted in-phantom treatment planning figures of merit. It is concluded that up to a proton energy of about 2.8 MeV there is no observed variation in the achievable therapy beam quality, but a price is paid in terms of treatment time for not choosing the upper limit of this range. For higher proton energies, the beam quality falls, but with no improvement in treatment time for optimum configurations.

  8. The use of numerical programs in research and academic institutions

    Science.gov (United States)

    Scupi, A. A.

    2016-08-01

    This paper is conceived on the idea that numerical programs using computer models of physical processes can be used both for scientific research and academic teaching to study different phenomena. Computational Fluid Dynamics (CFD) is used today on a large scale in research and academic institutions. CFD development is not limited to computer simulations of fluid flow phenomena. Analytical solutions for most fluid dynamics problems are already available for ideal or simplified situations for different situations. CFD is based on the Navier- Stokes (N-S) equations characterizing the flow of a single phase of any liquid. For multiphase flows the integrated N-S equations are complemented with equations of the Volume of Fluid Model (VOF) and with energy equations. Different turbulent models were used in the paper, each one of them with practical engineering applications: the flow around aerodynamic surfaces used as unconventional propulsion system, multiphase flows in a settling chamber and pneumatic transport systems, heat transfer in a heat exchanger etc. Some of them numerical results were validated by experimental results. Numerical programs are also used in academic institutions where certain aspects of various phenomena are presented to students (Bachelor, Master and PhD) for a better understanding of the phenomenon itself.

  9. Army/NASA small turboshaft engine digital controls research program

    Science.gov (United States)

    Sellers, J. F.; Baez, A. N.

    1981-01-01

    The emphasis of a program to conduct digital controls research for small turboshaft engines is on engine test evaluation of advanced control logic using a flexible microprocessor based digital control system designed specifically for research on advanced control logic. Control software is stored in programmable memory. New control algorithms may be stored in a floppy disk and loaded directly into memory. This feature facilitates comparative evaluation of different advanced control modes. The central processor in the digital control is an Intel 8086 16 bit microprocessor. Control software is programmed in assembly language. Software checkout is accomplished prior to engine test by connecting the digital control to a real time hybrid computer simulation of the engine. The engine currently installed in the facility has a hydromechanical control modified to allow electrohydraulic fuel metering and VG actuation by the digital control. Simulation results are presented which show that the modern control reduces the transient rotor speed droop caused by unanticipated load changes such as cyclic pitch or wind gust transients.

  10. Status of reduced enrichment programs for research reactors in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Kanda, Keiji; Nishihara, Hedeaki [Kyoto Univ., Osaka (Japan); Shirai, Eiji; Oyamada, Rokuro; Sanokawa, Konomo [Japan Atomic Energy Research Institute, Tokyo (Japan)

    1997-08-01

    The reduced enrichment programs for the JRR-2, JRR-3, JRR-4 and JMTR of Japan Atomic Energy Research Institute (JAERI), and the KUR of Kyoto University Research Reactor Institute (KURRI) have been partially completed and are mostly still in progress under the Joint Study Programs with Argonne National Laboratory (ANL). The JMTR and JRR-2 have been already converted to use MEU aluminide fuels in 1986 and 1987, respectively. The operation of the upgraded JRR-3(JRR-3M) has started in March 1990 with the LEU aluminide fuels. Since May 1992, the two elements have been inserted in the KUR. The safety review application for the full core conversion to use LEU silicide in the JMTR was approved in February 1992 and the conversion has been done in January 1994. The Japanese Government approved a cancellation of the KUHFR Project in February 1991, and in April 1994 the U.S. Government gave an approval to utilize HEU in the KUR instead of the KUHFR. Therefore, the KUR will be operated with HEU fuel until 2001. Since March 1994, Kyoto University is continuing negotiation with UKAEA Dounreay on spent fuel reprocessing and blending down of recovered uranium, in addition to that with USDOE.

  11. Developing laboratory research techniques for an ongoing research program in a high school classroom

    Science.gov (United States)

    Adornato, Philip

    Incorporating research into a high school classroom is an excellent way to teach students fundamental concepts in science. One program that incorporates this approach is the Waksman Student Scholar Program (WSSP), which allows high school students, teachers and Rutgers professors to work side by side on an ongoing molecular biology research program. Students in the program first isolated plasmid clones from bacteria that contain cDNA fragments of genes from the Brine Shrimp Artemia franciscana. They then determined the size of the DNA by performing molecular biology experiments. Students then analyzed the DNA sequence and after review from WSSP staff and high school teachers, the student's sequences were published in the National Center for Biotechnology Information (NCBI) database. This was often the last step in the project the students performed. However, if the project were being conducted in a research lab instead of a high school, the cDNA clone would often be further analyzed. In the past, safety, convenience, and affordability have limited the availability of these experiments in a high school setting. Although additional bioinformatic experiments could easily be performed in the high school, there is a strong need for additional "wet lab" experiments to keep the students engaged and motivated to work on the project. I have worked on developing three experimental modules that can be performed in a high school setting. These experiments were tested with the students and teachers of the WSSP. This work will expand the scope of experiments that can be performed in a high school environment.

  12. Polymer matrix composites research: A survey of federally sponsored programs

    Energy Technology Data Exchange (ETDEWEB)

    1990-06-01

    This report identifies research conducted by agencies of the federal government other than the Department of Energy (DOE) in the area of advanced polymer matrix composites (PMCs). DOE commissioned the report to avoid duplicating other agencies' efforts in planning its own research program for PMCs. PMC materials consist of high-strength, short or continuous fibers fused together by an organic matrix. Compared to traditional structural metals, PMCs provide greater strength and stiffness, reduced weight and increased heat resistance. The key contributors to PMC research identified by the survey are the Department of Defense (DOD), the National Aeronautics and Space Administration (NASA), the National Science Foundation (NSF), and the Department of Transportation (DOT). The survey identified a total of 778 projects. More than half of the total projects identified emphasize materials research with a goal toward developing materials with improved performance. Although an almost equal number of identified materials projects focus on thermosets and thermoplastics receive more attention because of their increased impact resistance and their easy formability and re-formability. Slightly more than one third of projects identified target structures research. Only 15 percent of the projects identified focus on manufacturing techniques, despite the need for efficient, economical methods manufacturing products constructed of PMCs--techniques required for PMCs to gain widespread acceptance. Three issues to be addressed concerning PMCs research are economy of use, improvements in processing, and education and training. Five target technologies have been identified that could benefit greatly from increased use of PMCs: aircraft fuselages, automobile frames, high-speed machinery, electronic packaging, and construction.

  13. Microbial enhanced oil recovery and wettability research program

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, C.P.; Bala, G.A.; Duvall, M.L.

    1991-07-01

    This report covers research results for the microbial enhanced oil recovery (MEOR) and wettability research program conducted by EG G Idaho, Inc. at the Idaho National Engineering Laboratory (INEL). The isolation and characterization of microbial species collected from various locations including target oil field environments is underway to develop more effective oil recovery systems for specific applications. The wettability research is a multi-year collaborative effort with the New Mexico Petroleum Recovery Research Center (NMPRRC), to evaluate reservoir wettability and its effects on oil recovery. Results from the wettability research will be applied to determine if alteration of wettability is a significant contributing mechanism for MEOR systems. Eight facultatively anaerobic surfactant producing isolates able to function in the reservoir conditions of the Minnelusa A Sands of the Powder River Basin in Wyoming were isolated from naturally occurring oil-laden environments. Isolates were characterized according to morphology, thermostability, halotolerance, growth substrates, affinity to crude oil/brine interfaces, degradative effects on crude oils, and biochemical profiles. Research at the INEL has focused on the elucidation of microbial mechanisms by which crude oil may be recovered from a reservoir and the chemical and physical properties of the reservoir that may impact the effectiveness of MEOR. Bacillus licheniformis JF-2 (ATCC 39307) has been used as a benchmark organism to quantify MEOR of medium weight crude oils (17.5 to 38.1{degrees}API) the capacity for oil recovery of Bacillus licheniformis JF-2 utilizing a sucrose-based nutrient has been elucidated using Berea sandstone cores. Spacial distribution of cells after microbial flooding has been analyzed with scanning electron microscopy. Also the effect of microbial surfactants on the interfacial tensions (IFT) of aqueous/crude oil systems has been measured. 87 refs., 60 figs., 15 tabs.

  14. Infrared Submillimeter and Radio Astronomy Research and Analysis Program

    Science.gov (United States)

    Traub, Wesley A.

    2000-01-01

    This program entitled "Infrared Submillimeter and Radio Astronomy Research and Analysis Program" with NASA-Ames Research Center (ARC) was proposed by the Smithsonian Astrophysical Observatory (SAO) to cover three years. Due to funding constraints only the first year installment of $18,436 was funded, but this funding was spread out over two years to try to maximize the benefit to the program. During the tenure of this contact, the investigators at the SAO, Drs. Wesley A. Traub and Nathaniel P. Carleton, worked with the investigators at ARC, Drs. Jesse Bregman and Fred Wittebom, on the following three main areas: 1. Rapid scanning SAO and ARC collaborated on purchasing and constructing a Rapid Scan Platform for the delay arm of the Infrared-Optical Telescope Array (IOTA) interferometer on Mt. Hopkins, Arizona. The Rapid Scan Platform was tested and improved by the addition of stiffening plates which eliminated a very small but noticeable bending of the metal platform at the micro-meter level. 2. Star tracking Bregman and Wittebom conducted a study of the IOTA CCD-based star tracker system, by constructing a device to simulate star motion having a specified frequency and amplitude of motion, and by examining the response of the tracker to this simulated star input. 3. Fringe tracking. ARC, and in particular Dr. Robert Mah, developed a fringe-packet tracking algorithm, based on data that Bregman and Witteborn obtained on IOTA. The algorithm was tested in the laboratory at ARC, and found to work well for both strong and weak fringes.

  15. Carbon Dioxide Effects Research and Assessment Program: Proceedings of the carbon dioxide and climate research program conference

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, L E [ed.

    1980-12-01

    Papers presented at the Carbon Dioxide and Climate Research Program Conference are included in this volume. Topics discussed are: the carbon cycle; modeling the carbon system; climatic response due to increased CO2; climate modeling; the use of paleoclimatic data in understanding climate change; attitudes and implications of CO2; social responses to the CO2 problem; a scenario for atmospheric CO2 to 2025; marine photosynthesis and the global carbon cycle; and the role of tropical forests in the carbon balance of the world. Separate abstracts of nine papers have been prepared for inclusion in the Energy Data Base. (RJC)

  16. Commercial Building Energy Asset Rating Program -- Market Research

    Energy Technology Data Exchange (ETDEWEB)

    McCabe, Molly J.; Wang, Na

    2012-04-19

    Under contract to Pacific Northwest National Laboratory, HaydenTanner, LLC conducted an in-depth analysis of the potential market value of a commercial building energy asset rating program for the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy. The market research objectives were to: (1) Evaluate market interest and need for a program and tool to offer asset rating and rapidly identify potential energy efficiency measures for the commercial building sector. (2) Identify key input variables and asset rating outputs that would facilitate increased investment in energy efficiency. (3) Assess best practices and lessons learned from existing national and international energy rating programs. (4) Identify core messaging to motivate owners, investors, financiers, and others in the real estate sector to adopt a voluntary asset rating program and, as a consequence, deploy high-performance strategies and technologies across new and existing buildings. (5) Identify leverage factors and incentives that facilitate increased investment in these buildings. To meet these objectives, work consisted of a review of the relevant literature, examination of existing and emergent asset and operational rating systems, interviews with industry stakeholders, and an evaluation of the value implication of an asset label on asset valuation. This report documents the analysis methodology and findings, conclusion, and recommendations. Its intent is to support and inform the DOE Office of Energy Efficiency and Renewable Energy on the market need and potential value impacts of an asset labeling and diagnostic tool to encourage high-performance new buildings and building efficiency retrofit projects.

  17. A experimental research program on chirality at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Markert, Christina [Univ. of Texas, Austin, TX (United States)

    2016-09-01

    Heavy-ion collisions provide a unique opportunity to investigate the fundamental laws of physics of the strong force. The extreme conditions created by the collisions within a finite volume are akin to the properties of the deconfined partonic state which existed very shortly after the Big Bang and just prior to visible matter formation in the Universe. In this state massless quarks and gluons (partons) are ``quasi free" particles, the so-called Quark Gluon Plasma (QGP). By following the expansion and cooling of this state, we will map out the process of nucleonic matter formation, which occurs during the phase transition. The fundamental properties of this early partonic phase of matter are not well understood, but they are essential for confirming QCD (Quantum Chromo-Dynamics) and the Standard Model. The specific topic, chiral symmetry restoration, has been called ``the remaining puzzle of QCD.'' This puzzle can only be studied in the dense partonic medium generated in heavy-ion collisions. The research objectives of this proposal are the development and application of new analysis strategies to study chirality and the properties of the medium above the QGP phase transition using hadronic resonances detected with the ALICE experiment at the Large Hadron Collider (LHC) at the CERN research laboratory in Switzerland. This grant funded a new effort at the University of Texas at Austin (UT Austin) to investigate the Quark Gluon Plasma (QGP) at the highest possible energy of 2.76 TeV per nucleon at the Large Hadron Collider (LHC) at CERN via the ALICE experiment. The findings added to our knowledge of the dynamical evolution and the properties of the hot, dense matter produced in heavy-ion collisions, and provided a deeper understanding of multi-hadron interactions in these extreme nuclear matter systems. Our group contributed as well to the hardware and software for the ALICE USA-funded Calorimeter Detector (EMCal). The LHC research program and its

  18. A experimental research program on chirality at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Markert, Christina [Univ. of Texas, Austin, TX (United States)

    2016-09-01

    Heavy-ion collisions provide a unique opportunity to investigate the fundamental laws of physics of the strong force. The extreme conditions created by the collisions within a finite volume are akin to the properties of the deconfined partonic state which existed very shortly after the Big Bang and just prior to visible matter formation in the Universe. In this state massless quarks and gluons (partons) are ``quasi free" particles, the so-called Quark Gluon Plasma (QGP). By following the expansion and cooling of this state, we will map out the process of nucleonic matter formation, which occurs during the phase transition. The fundamental properties of this early partonic phase of matter are not well understood, but they are essential for confirming QCD (Quantum Chromo-Dynamics) and the Standard Model. The specific topic, chiral symmetry restoration, has been called ``the remaining puzzle of QCD.'' This puzzle can only be studied in the dense partonic medium generated in heavy-ion collisions. The research objectives of this proposal are the development and application of new analysis strategies to study chirality and the properties of the medium above the QGP phase transition using hadronic resonances detected with the ALICE experiment at the Large Hadron Collider (LHC) at the CERN research laboratory in Switzerland. This grant funded a new effort at the University of Texas at Austin (UT Austin) to investigate the Quark Gluon Plasma (QGP) at the highest possible energy of 2.76 TeV per nucleon at the Large Hadron Collider (LHC) at CERN via the ALICE experiment. The findings added to our knowledge of the dynamical evolution and the properties of the hot, dense matter produced in heavy-ion collisions and provided a deeper understanding of multi-hadron interactions in these extreme nuclear matter systems. Our group contributed as well to the hardware and software for the ALICE USA funded Calorimeter Detector (EMCal). The LHC research program and its

  19. 47 CFR 101.405 - Adherence to program of research and development.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Adherence to program of research and... AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Developmental Authorizations § 101.405 Adherence to program of research and development. The program of research and development, as stated by...

  20. MCTP Summer Research Internship Program. Research Presentation Day: Experience Mathematics and Science in the Real World

    Science.gov (United States)

    1996-01-01

    This paper presents the summaries of the MCTP Summer Research Internship Program. Technological areas discussed include: Mathematical curriculum development for real world problems; Rain effects on air-water gas exchange; multi-ring impact basins on mars; developing an interactive multimedia educational cd-rom on remote sensing; a pilot of an activity for for the globe program; fossils in maryland; developing children's programming for the american horticultural society at river farm; children's learning, educational programs of the national park service; a study of climate and student satisfaction in two summer programs for disadvantaged students interested in careers in mathematics and science; the maryland governor's academy, integrating technology into the classroom; stream sampling with the maryland biological stream survey (MBSS); the imaging system inspection software technology, the preparation and detection of nominal and faulted steel ingots; event-based science, the development of real-world science units; correlation between anxiety and past experiences; environmental education through summer nature camp; enhancing learning opportunities at the Salisbury zoo; plant growth experiment, a module for the middle school classroom; the effects of proxisome proliferators in Japanese medaka embryos; development of a chapter on birth control and contraceptive methodologies as part of an interactive computer-based education module on hiv and aids; excretion of gentamicin in toadfish and goldfish; the renaissance summer program; and Are field trips important to the regional math science center?

  1. Annual program analysis of the NASA Space Life Sciences Research and Education Support Program

    Science.gov (United States)

    1994-01-01

    The basic objectives of this contract are to stimulate, encourage, and assist research and education in NASA life sciences. Scientists and experts from a number of academic and research institutions in this country and abroad are recruited to support NASA's need to find a solution to human physiological problems associated with living and working in space and on extraterrestrial bodies in the solar system. To fulfill the contract objectives, a cadre of staff and visiting scientists, consultants, experts, and subcontractors has been assembled into a unique organization dedicated to the space life sciences. This organization, USRA's Division of Space Life Sciences, provides an academic atmosphere, provides an organizational focal point for science and educational activities, and serves as a forum for the participation of eminent scientists in the biomedical programs of NASA. The purpose of this report is to demonstrate adherence to the requirement of Contract NAS9-18440 for a written review and analysis of the productivity and success of the program. In addition, this report makes recommendations for future activities and conditions to further enhance the objectives of the program and provides a self-assessment of the cost performance of the contract.

  2. 2016 Fermilab Laboratory Directed Research & Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wester, W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2016-05-25

    Fermilab is executing Laboratory Directed Research and Development (LDRD) as outlined by order DOE O 413.2B in order to enhance and realize the mission of the laboratory in a manner that also supports the laboratory’s strategic objectives and the mission of the Department of Energy. LDRD funds enable scientific creativity, allow for exploration of “high risk, high payoff” research, and allow for the demonstration of new ideas, technical concepts, and devices. LDRD also has an objective of maintaining and enhancing the scientific and technical vitality of Fermilab. LDRD is able to fund employee-initiated proposals that address the current strategic objectives and better position Fermilab for future mission needs. The request for such funds is made in consideration of the investment needs, affordability, and directives from DOE and Congress. Review procedures of the proposals will insure that those proposals which most address the strategic goals of the DOE and the Laboratory or which best position Fermilab for the future will be recommended to the Laboratory Director who has responsibility for approval. The execution of each approved project will be the responsibility of the Principal Investigator, PI, who will follow existing Laboratory guidelines to ensure compliance with safety, environmental, and quality assurance practices. A Laboratory Director-appointed LDRD Coordinator will work with Committees, Laboratory Management, other Fermilab Staff, and the PI’s to oversee the implementation of policies and procedures of LDRD and provide the management and execution of this Annual Program Plan. FY16 represents third fiscal year in which LDRD has existed at Fermilab. The number of preliminary proposals (117) submitted in response to the LDRD Call for Proposals indicates very strong interest of the program within the Fermilab community. The first two Calls have resulted in thirteen active LDRD projects – and it is expected that between five and seven new

  3. Energy and environment annual report 1974. [Environmental Research programs

    Energy Technology Data Exchange (ETDEWEB)

    Blumstein, C. (ed.)

    1974-01-01

    Research in the Division's environmental science program includes air pollution, water pollution, and the effects of pollutants on man and natural ecosystems. Work has focused on the chemistry and physics of particle surfaces. Using the technique of electron spectroscopy for chemical analysis (ESCA), surface reactions of sulfur and nitrogen compounds have been studied, and results include the identification of new chemical forms of nitrogen on particle surfaces and evidence for the importance of particle surfaces in the catalysis of sulfur dioxide to sulfuric acid. The Division's work in water pollution has been devoted to the study of trace metals in the estuarine environment, especially in San Francisco Bay. Studies on the effect of dredging operations on trace metals in the Mare Island ship channel and on the distribution of cadmium in Bay sediments have been performed. Research has also been conducted on the distribution of trace elements between bound states on suspended particles and in solution in Bay waters. Research is being conducted on a variety of problems relating to effects of pollutants. Biological studies seeking to discover effects of specific environmental insults such as oxidants at the cellular level have been done, and epidemiological studies have been initiated on the impacts of trace metals on human health. Theoretical studies in an attempt to develop a basis for assessing the stability of ecological systems are also being undertaken.

  4. An overview of the Nuclear Materials Focus Area research program

    Energy Technology Data Exchange (ETDEWEB)

    ROBERSON,GARY D.; POLANSKY,GARY F.; OSBORNE,KEN K.; RANDALL,VIRGINIA

    2000-02-25

    The Nuclear Material Focus Area (NMFA) is responsible for providing comprehensive needs identification, integration of technology research and development activities, and technology deployment for stabilization, packaging, and interim storage of surplus nuclear materials within the DOE complex. The NMFA was chartered in April 1999 by the Office of Science and Technology (OST), an organizational component of the US Department of Energy's (DOE) Office of Environmental Management (EM). OST manages a national program to conduct basic and applied research, and technology development, demonstration, and deployment assistance that is essential to completing a timely and cost-effective cleanup of the DOE nuclear weapons complex. DOE/EM provides environmental research results, as well as cleanup technologies and systems, to meet high-priority end-user needs, reduce EM's major cost centers and technological risks, and accelerate technology deployments. The NMFA represents the segment of EM that focuses on technological solutions for re-using, transforming, and disposing excess nuclear materials and is jointly managed by the DOE Albuquerque Operations Office and the DOE Idaho Operations Office.

  5. Next Generation Nuclear Plant Materials Research and Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    G.O. Hayner; R.L. Bratton; R.N. Wright

    2005-09-01

    The U.S Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design will be a graphite moderated, helium-cooled, prismatic or pebble-bed, thermal neutron spectrum reactor that will produce electricity and hydrogen in a state-of-the-art thermodynamically efficient manner. The NGNP will use very high burn-up, low-enriched uranium, TRISO-coated fuel and have a projected plant design service life of 60 years. The VHTR concept is considered to be the nearest-term reactor design that has the capability to efficiently produce hydrogen. The plant size, reactor thermal power, and core configuration will ensure passive decay heat removal without fuel damage or radioactive material releases during accidents. The NGNP Project is envisioned to demonstrate the following: (1) A full-scale prototype VHTR by about 2021; (2) High-temperature Brayton Cycle electric power production at full scale with a focus on economic performance; (3) Nuclear-assisted production of hydrogen (with about 10% of the heat) with a focus on economic performance; and (4) By test, the exceptional safety capabilities of the advanced gas-cooled reactors. Further, the NGNP program will: (1) Obtain a Nuclear Regulatory Commission (NRC) License to construct and operate the NGNP, this process will provide a basis for future performance based, risk-informed licensing; and (2) Support the development, testing, and prototyping of hydrogen infrastructures. The NGNP Materials Research and Development (R&D) Program is responsible for performing R&D on likely NGNP materials in support of the NGNP design, licensing, and construction activities. The NGNP Materials R&D Program includes the following elements: (1) Developing a specific approach, program plan and other project management tools for

  6. Aeronautics Research Mission Directorate Integrated Systems Research Program (ISRP) and UAS Integration in the NAS Project

    Science.gov (United States)

    Wolfe, Jean

    2010-01-01

    Program Goal: Conduct research at an integrated system-level on promising concepts and technologies and explore, assess, or demonstrate the benefits in a relevant environment.Criteria for selection of projects for Integrated Systems Research: a) Technology has attained enough maturity in the foundational research program that they merit more in-depth evaluation at an integrated system level in a relevant environment. b) Technologies which systems analysis indicates have the most potential for contributing to the simultaneous attainment of goals. c) Technologies identified through stakeholder input as having potential for simultaneous attainment of goals. d) Research not being done by other government agencies and appropriate for NASA to conduct. e) Budget augmentation. Environmentally Responsible Aviation (ERA) Project Explore and assess new vehicle concepts and enabling technologies through system-level experimentation to simultaneously reduce fuel burn, noise, and emissions Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project Contribute capabilities that reduce technical barriers related to the safety and operational challenges associated with enabling routine UAS access to the NAS Innovative Concepts for Green Aviation (ICGA) Project Spur innovation by offering research opportunities to the broader aeronautics community through peer-reviewed proposals, with a focus on making aviation more eco-friendly. Establish incentive prizes similar to the Centennial Challenges and sponsor innovation demonstrations of selected technologies that show promise of reducing aviation s impact on the environment

  7. Human Research Program 2010 Chair Standing Review Panel Meeting

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    The 13 Human Research Program (HRP) Standing Review Panel (SRP) Chairs, and in some cases one or two additional panel members (see section XIV, roster) referred to as the Chair (+1) SRP throughout this document, met at the NASA Johnson Space Center (JSC) on December 7, 2010 to allow the HRP Elements and Projects to report on their progress over the past year, their current status, and their plans for the upcoming year based on NASA's current goals and objectives for human space exploration. A large focus of the meeting was also used to discuss integration across the HRP scientific disciplines based on a recommendation from the 2009 HRP SRP review. During the one-day meeting, each of the HRP Elements and Projects presented the changes they made to the HRP Integrated Research Plan (IRP Rev. B) over the last year, and what their top three areas of integration are between other HRP Elements/Projects. The Chair (+1) SRP spent sufficient time addressing the panel charge, either as a group or in a separate closed session, and the Chair (+1) SRP and the HRP presenters and observers, in most cases, had sufficient time to discuss during and after the presentations. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, prior to the close of the meeting on December 7, 2010. Overall, the Chair (+1) SRP concluded that most of the HRP Elements/Projects did a commendable job during the past year in addressing integration across the HRP scientific disciplines with the available resources. The Chair (+1) SRP agreed that the idea of integration between HRP Elements/Projects is noble, but believes all parties involved should have the same definition of integration, in order to be successful. The Chair (+1) SRP also believes that a key to successful integration is communication among the HRP Elements/Projects which may present a challenge. The Chair (+1) SRP recommends that the HRP have a workshop on program integration (with HRP Element

  8. Earth resources programs at the Langley Research Center. Part 1: Advanced Applications Flight Experiments (AAFE) and microwave remote sensing program

    Science.gov (United States)

    Parker, R. N.

    1972-01-01

    The earth resources activity is comprised of two basic programs as follows: advanced applications flight experiments, and microwave remote sensing. The two programs are in various stages of implementation, extending from experimental investigations within both the AAFE program and the microwave remote sensing program, to multidisciplinary studies and planning. The purpose of this paper is simply to identify the main thrust of the Langley Research Center activity in earth resources.

  9. The Multi-Disciplinary Graduate Program in Educational Research. Final Report, Part VII; Evaluation of the Multi-Disciplinary Program in Educational Research.

    Science.gov (United States)

    Lazarsfeld, Paul F., Ed.

    In the Multi-Disciplinary Graduate Program in Educational Research, graduate students at the doctoral level were participants. This program required exposure to other disciplines, to various approaches to problem definition, to various methodologies, concepts, and research techniques. It was expected that the students had gained experiences and…

  10. Equipment fragility data base. Seismic Safety Margins Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Cover, L.E.

    1983-01-10

    Part of the effort of the Seismic Safety Margins Research Program (SSMRP) has been directed at generating a fragility data base for equipment used in control and safety systems in commercial nuclear power plants. Component fragility data have been compiled in various forms, depending on their content, intended use, and level of reduction. The data are stored in a relational data base on the LLNL CEC 7600 computers; this provides easy accessibility for LLNL computer users. This report describes the present structure of the data base and presents its contents through the use of tables. This report is a revision of an earlier one of the same name and numbers (NUREG/CR-2680) and (UCRL-53038). Additional data have been included and the presentation has been revised to enhance its usability.

  11. 75 FR 41392 - Sorghum Promotion and Research Program: Procedures for the Conduct of Referenda

    Science.gov (United States)

    2010-07-16

    ... Agricultural Marketing Service 7 CFR Part 1221 Sorghum Promotion and Research Program: Procedures for the... Commodity Promotion, Research, and Information Act of 1996 (Act) authorizes a program of promotion, research, and information to be developed through the promulgation of the Sorghum Promotion, Research,...

  12. Integrating Health Research into Disaster Response: The New NIH Disaster Research Response Program.

    Science.gov (United States)

    Miller, Aubrey; Yeskey, Kevin; Garantziotis, Stavros; Arnesen, Stacey; Bennett, April; O'Fallon, Liam; Thompson, Claudia; Reinlib, Les; Masten, Scott; Remington, James; Love, Cindy; Ramsey, Steve; Rosselli, Richard; Galluzzo, Betsy; Lee, Joy; Kwok, Richard; Hughes, Joseph

    2016-07-04

    The need for high quality and timely disaster research has been a topic of great discussion over the past several years. Recent high profile incidents have exposed gaps in knowledge about the health impacts of disasters or the benefits of specific interventions-such was the case with the 2010 Gulf Oil Spill and recent events associated with lead-contaminated drinking water in Flint, Michigan, and the evolving health crisis related to Zika virus disease. Our inability to perform timely research to inform the community about health and safety risks or address specific concerns further heightens anxiety and distrust. Since nearly all disasters, whether natural or man-made, have an environmental health component, it is critical that specialized research tools and trained researchers be readily available to evaluate complex exposures and health effects, especially for vulnerable sub-populations such as the elderly, children, pregnant women, and those with socioeconomic and environmental disparities. In response, the National Institute of Environmental Health Science has initiated a Disaster Research Response Program to create new tools, protocols, networks of researchers, training exercises, and outreach involving diverse groups of stakeholders to help overcome the challenges of disaster research and to improve our ability to collect vital information to reduce the adverse health impacts and improve future preparedness.

  13. Integrating Health Research into Disaster Response: The New NIH Disaster Research Response Program

    Directory of Open Access Journals (Sweden)

    Aubrey Miller

    2016-07-01

    Full Text Available The need for high quality and timely disaster research has been a topic of great discussion over the past several years. Recent high profile incidents have exposed gaps in knowledge about the health impacts of disasters or the benefits of specific interventions—such was the case with the 2010 Gulf Oil Spill and recent events associated with lead-contaminated drinking water in Flint, Michigan, and the evolving health crisis related to Zika virus disease. Our inability to perform timely research to inform the community about health and safety risks or address specific concerns further heightens anxiety and distrust. Since nearly all disasters, whether natural or man-made, have an environmental health component, it is critical that specialized research tools and trained researchers be readily available to evaluate complex exposures and health effects, especially for vulnerable sub-populations such as the elderly, children, pregnant women, and those with socioeconomic and environmental disparities. In response, the National Institute of Environmental Health Science has initiated a Disaster Research Response Program to create new tools, protocols, networks of researchers, training exercises, and outreach involving diverse groups of stakeholders to help overcome the challenges of disaster research and to improve our ability to collect vital information to reduce the adverse health impacts and improve future preparedness.

  14. Integrating Health Research into Disaster Response: The New NIH Disaster Research Response Program

    Science.gov (United States)

    Miller, Aubrey; Yeskey, Kevin; Garantziotis, Stavros; Arnesen, Stacey; Bennett, April; O’Fallon, Liam; Thompson, Claudia; Reinlib, Les; Masten, Scott; Remington, James; Love, Cindy; Ramsey, Steve; Rosselli, Richard; Galluzzo, Betsy; Lee, Joy; Kwok, Richard; Hughes, Joseph

    2016-01-01

    The need for high quality and timely disaster research has been a topic of great discussion over the past several years. Recent high profile incidents have exposed gaps in knowledge about the health impacts of disasters or the benefits of specific interventions—such was the case with the 2010 Gulf Oil Spill and recent events associated with lead-contaminated drinking water in Flint, Michigan, and the evolving health crisis related to Zika virus disease. Our inability to perform timely research to inform the community about health and safety risks or address specific concerns further heightens anxiety and distrust. Since nearly all disasters, whether natural or man-made, have an environmental health component, it is critical that specialized research tools and trained researchers be readily available to evaluate complex exposures and health effects, especially for vulnerable sub-populations such as the elderly, children, pregnant women, and those with socioeconomic and environmental disparities. In response, the National Institute of Environmental Health Science has initiated a Disaster Research Response Program to create new tools, protocols, networks of researchers, training exercises, and outreach involving diverse groups of stakeholders to help overcome the challenges of disaster research and to improve our ability to collect vital information to reduce the adverse health impacts and improve future preparedness. PMID:27384574

  15. A design study for an accelerator-based epithermal neutron beam for BNCT.

    Science.gov (United States)

    Allen, D A; Beynon, T D

    1995-05-01

    An achievable design concept for a boron neutron capture therapy (BNCT) facility, based on a high-current, low-energy proton accelerator, is described. Neutrons are produced within a thick natural lithium target, under bombardment from protons with an initial energy between 2.5 and 3.0 MeV. The proton current will be up to 10 mA. After gamma-ray filtering, the neutrons are partially moderated to epithermal energies within a heavy-water moderator, poisoned with 6Li to remove thermal neutrons. Monte Carlo modelling has been used to predict system performance in terms of neutron fluence rate and neutron and gamma-ray dose at the patient position. The relationship between the system performance and key parameters, such as proton energy, moderator depth and 6Li concentration, has been investigated. With a proton current of 10 mA, the facility is capable of providing a therapy beam with a useful neutron fluence rate of 10(9) cm-2 s-1 and a neutron dose per unit fluence of less than 6 x 10(-13) Gy cm2, with a gamma-ray contamination of the therapy beam of about 10(-13) Gy cm2.

  16. Dose calculation and in-phantom measurement in BNCT using response matrix method.

    Science.gov (United States)

    Rahmani, Faezeh; Shahriari, Majid

    2011-12-01

    In-phantom measurement of physical dose distribution is very important for Boron Neutron Capture Therapy (BNCT) planning validation. If any changes take place in therapeutic neutron beam due to the beam shaping assembly (BSA) change, the dose will be changed so another group of simulations should be carried out for dose calculation. To avoid this time consuming procedure and speed up the dose calculation to help patients not wait for a long time, response matrix method was used. This procedure was performed for neutron beam of the optimized BSA as a reference beam. These calculations were carried out using the MCNPX, Monte Carlo code. The calculated beam parameters were measured for a SNYDER head phantom placed 10 cm away from beam the exit of the BSA. The head phantom can be assumed as a linear system and neutron beam and dose distribution can be assumed as an input and a response of this system (head phantom), respectively. Neutron spectrum energy was digitized into 27 groups. Dose response of each group was calculated. Summation of these dose responses is equal to a total dose of the whole neutron/gamma spectrum. Response matrix is the double dimension matrix (energy/dose) in which each parameter represents a depth-dose resulted from specific energy. If the spectrum is changed, response of each energy group may be differed. By considering response matrix and energy vector, dose response can be calculated. This method was tested for some BSA, and calculations show statistical errors less than 10%.

  17. BDTPS The BNCT Treatment Planning System jointly developed at DIMNP and JRC/IE

    CERN Document Server

    Daquino, G G; Mazzini, M; Moss, R; Muzi, L; International Workshop on "Neutron Capture Therapy: State of the art"

    2003-01-01

    The idea to couple the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the new methodology set-up at DIMNP of University of Pisa, in collaboration with the JRC of Petten (NL). The methodology has been implemented in the new TPS, called BDTPS (Boron Distribution Treatment Planning System), which takes into account the actual boron distribution in the patient brain, while the standard TPS assumes a uniform boron distribution, absolutely far from the reality. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The new TPS, based on the Monte Carlo technique, has been validated comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designed, as calculated by the BDTPS and by the standard TPS SERA. An evident SERA overestimation of the thermal neutron flux, as well as the boron dose, has been detect...

  18. An optimized neutron-beam shaping assembly for accelerator-based BNCT.

    Science.gov (United States)

    Burlon, A A; Kreiner, A J; Valda, A A; Minsky, D M

    2004-11-01

    Different materials and proton beam energies have been studied in order to search for an optimized neutron production target and beam shaping assembly for accelerator-based BNCT. The solution proposed in this work consists of successive stacks of Al, polytetrafluoroethylene, commercially known as Teflon, and LiF as moderator and neutron absorber, and Pb as reflector. This assembly is easy to build and its cost is relatively low. An exhaustive Monte Carlo simulation study has been performed evaluating the doses delivered to a Snyder model head phantom by a neutron production Li-metal target based on the (7)Li(p,n)(7)Be reaction for proton bombarding energies of 1.92, 2.0, 2.3 and 2.5 MeV. Three moderator thicknesses have been studied and the figures of merit show the advantage of irradiating with near-resonance-energy protons (2.3 MeV) because of the relatively high neutron yield at this energy, which at the same time keeps the fast neutron healthy tissue dose limited and leads to the lowest treatment times. A moderator of 34 cm length has shown the best performance among the studied cases.

  19. An optimized neutron-beam shaping assembly for accelerator-based BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Burlon, A.A. E-mail: burlon@tandar.cnea.gov.ar; Kreiner, A.J.; Valda, A.A.; Minsky, D.M

    2004-11-01

    Different materials and proton beam energies have been studied in order to search for an optimized neutron production target and beam shaping assembly for accelerator-based BNCT. The solution proposed in this work consists of successive stacks of Al, polytetrafluoroethylene, commercially known as Teflon[reg ], and LiF as moderator and neutron absorber, and Pb as reflector. This assembly is easy to build and its cost is relatively low. An exhaustive Monte Carlo simulation study has been performed evaluating the doses delivered to a Snyder model head phantom by a neutron production Li-metal target based on the {sup 7}Li(p,n){sup 7}Be reaction for proton bombarding energies of 1.92, 2.0, 2.3 and 2.5 MeV. Three moderator thicknesses have been studied and the figures of merit show the advantage of irradiating with near-resonance-energy protons (2.3 MeV) because of the relatively high neutron yield at this energy, which at the same time keeps the fast neutron healthy tissue dose limited and leads to the lowest treatment times. A moderator of 34 cm length has shown the best performance among the studied cases.

  20. Spectromicroscopy of boron for the optimization of boron neutron capture therapy (BNCT) for cancer

    Science.gov (United States)

    Gilbert, B.; Redondo, J.; Baudat, P.-A.; Lorusso, G. F.; Andres, R.; Van Meir, E. G.; Brunet, J.-F.; Hamou, M.-F.; Suda, T.; Mercanti, Delio; Ciotti, M. Teresa; Droubay, T. C.; Tonner, B. P.; Perfetti, P.; Margaritondo, M.; DeStasio, Gelsomina

    1998-10-01

    We used synchrotron spectromicroscopy to study the microscopic distribution of boron in rat brain tumour and healthy tissue in the field of boron neutron capture therapy (BNCT). The success of this experimental cancer therapy depends on the preferential uptake of ? in tumour cells after injection of a boron compound (in our case ?, or BSH). With the Mephisto (microscope à emission de photoélectrons par illumination synchrotronique de type onduleur) spectromicroscope, high-magnification imaging and chemical analysis was performed on brain tissue sections from a rat carrying an implanted brain tumour and the results were compared with inductively coupled plasma-atomic emission spectroscopy (ICP-AES) detection of boron in bulk tissue. Boron was found to have been taken up more favourably by regions of tumour rather than healthy tissue, but the resulting boron distribution in the tumour was inhomogeneous. The results demonstrate that Mephisto can perform microchemical analysis of tissue sections, detect and localize the presence of boron with submicron spatial resolution. The application of this technique to boron in brain tissue can therefore be used to evaluate the current efforts to optimize BNC therapy.