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Sample records for bnct research program

  1. INEL BNCT Research Program annual report 1994

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included

  2. INEL BNCT Research Program annual report 1994

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  3. INEL BNCT Research Program annual report, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.

  4. INEL BNCT Research Program annual report, 1992

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database

  5. INEL BNCT research program: Annual report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented.

  6. INEL BNCT research program: Annual report, 1995

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented

  7. INEEL BNCT Research Program Annual Report, CY-2000

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, James Robert

    2001-03-01

    This report is a summary of the activities conducted in conjunction with the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 2000. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, neutron source design and demonstration, and support the Department of Energy’s (DOE) National BNCT Program goals are the goals of this Program. Contributions from the individual contributors about their projects are included, specifically described are the following, chemistry: analysis of biological samples and an infrared blood-boron analyzer, and physics: progress in the patient treatment planning software, measurement of neutron spectra for the Argentina RA-6 reactor, and recalculation of the Finnish research reactor FiR 1 neutron spectra, BNCT accelerator technology, and modification to the research reactor at Washington State University for an epithermal-neutron beam.

  8. INEL BNCT research program publications, 1993

    International Nuclear Information System (INIS)

    1994-05-01

    This document is a collection of the published reports describing research supporting the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). These reports have previously appeared in the book: Advances in Neutron Capture Therapy, edited by A. H. Soloway, R. F. Barth, D. E. Carpenter, Plenum Press, 1993. Reports have also appeared in three journals: Angewandte Chemie, Strahlentherapie und Onkologie, and Nuclear Science and Engineering. This individual papers have been indexed separately elsewhere

  9. INEL BNCT Research Program Annual Report 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1994-08-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from all the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, boron drug analysis), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented. Results of 21 spontaneous-tumor-bearing dogs that have been treated with boron neutron capture therapy at the Brookhaven National Laboratory are updated. Boron-containing drug purity verification is discussed in some detail. Advances in magnetic resonance imaging of boron in vivo are discussed. Several boron-carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Measurement of the epithermal-neutron flux of the Petten (The Netherlands) High Flux Reactor beam (HFB11B), and comparison to predictions are shown.

  10. INEL BNCT Program

    International Nuclear Information System (INIS)

    Ackermann, A.L.; Dorn, R.V. III.

    1991-03-01

    This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program for March 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, a milestone summary, and animal data charts

  11. INEL BNCT Program

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.)

    1991-08-01

    This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  12. INEL BNCT Research Program, January/February 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-04-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  13. INEL BNCT Research Program, May/June 1992

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1992-09-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (IBPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed

  14. INEL BNCT Research Program, September--October 1992

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1992-12-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotain. carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophonylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed

  15. INEL BNCT Research Program, September--October 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-12-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotain. carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophonylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  16. INEL BNCT Research Program, January/February 1993

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1993-04-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed

  17. INEL BNCT Research Program, March/April 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1992-09-01

    This report presents summaries for two months of current research for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murino screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronopheoylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.

  18. INEEL BNCT research program. Annual report, January 1, 1996--December 31, 1996

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1997-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of 10 B enriched decaborane

  19. INEEL BNCT research program. Annual report, January 1, 1996--December 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1997-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of {sup 10}B enriched decaborane.

  20. INEL BNCT Research Program, March/April 1993

    International Nuclear Information System (INIS)

    Venhuizen, J.R.

    1993-06-01

    This report presents summaries for two months of current research of the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium and boronophenylalanine are described. Treatment protocol development via the large animal (canine) modal studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed

  1. INEL BNCT Program: Volume 5, No. 9

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.)

    1991-01-01

    This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  2. INEL BNCT Program: Volume 5, No. 9. Bulletin, September 1991

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. [ed.

    1991-12-31

    This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  3. Neutron beams implemented at nuclear research reactors for BNCT

    Science.gov (United States)

    Bavarnegin, E.; Kasesaz, Y.; Wagner, F. M.

    2017-05-01

    This paper presents a survey of neutron beams which were or are in use at 56 Nuclear Research Reactors (NRRs) in order to be used for BNCT, either for treatment or research purposes in aspects of various combinations of materials that were used in their Beam Shaping Assembly (BSA) design, use of fission converters and optimized beam parameters. All our knowledge about BNCT is indebted to researches that have been done in NRRs. The results of about 60 years research in BNCT and also the successes of this method in medical treatment of tumors show that, for the development of BNCT as a routine cancer therapy method, hospital-based neutron sources are needed. Achieving a physical data collection on BNCT neutron beams based on NRRs will be helpful for beam designers in developing a non-reactor based neutron beam.

  4. Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research

    Energy Technology Data Exchange (ETDEWEB)

    Subhash Chandra

    2008-05-30

    The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.

  5. Development of cancer therapy facility of Hanaro and medical research in BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Byung Jin; Kim, M. S.; Kim, M. J.; Park, S. J. [KAERI, Taejon (Korea, Republic of); Lee, C. H.; Kwack, H. S.; Kim, M. S. [Korea Inst. of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, J. K.; Park, S. H.; Shin, C. H. [Hanyang Univ., Seoul (Korea, Republic of)

    2003-05-01

    In order to support the domestic research on the Boron Neutron Capture Therapy(BNCT) which is a promising treatment method for tumor in principle, a neutron irradiation facility and a Prompt Gamma Neutron Activation Analysis (PGNAA) equipment for the boron concentration measurement are developed and installed at Hanaro. Meanwhile basic research has been performed to develop BNCT medical technology using above Hanaro facilities when they are ready. The Hanaro BNCT facility gives almost pure thermal neutron beam, it can be applied to all level of BNCT research from the cell culture and animal study to clinical trials by focussed irradiation, and its use does not cause any interference with other utilization. It can also be used for other purposes such as standard thermal neutron field and a dynamic neutron radiography with excellent features. The PGNAA equipment will be used not only for the boron concentration measurement but also for the general multi-element simultaneous analyses. The medical research for BNCT covers basic research on dose evaluation, boron compound behaviour and new compound development. Technologies for neutron and gamma transport calculation and their measurement, and micro dosimetry are developed. While import of a dose planning program has been pushed, domestic development of the program has been tried. Imaging technologies for boron distribution using SPECT or PET are developed by labeling I-123 or F-18 to BPA. Data for the BPA accumulation into the brain tumor are produced by clinical trials of the technology. A general and versatile method for the synthesis of o-carborane clusters containing of their important biological activities as neurotransmitter, antipsychotic or anticancer is developed. We found three promising compounds of which accumulation into B-16 melanoma cell is about 10 times of BPA.

  6. Nuclear engineering aspects of glioma BNCT research in Italy

    International Nuclear Information System (INIS)

    Curzio, G.; Mazzini, M.

    1998-01-01

    A research project on Boron Neutron Capture Therapy (BNCZ) of gliomas has been set up in Italy, with the participation of Departments of Oncology and Mechanical and Nuclear Construction (DCMN) of the University of Pisa, as well as the Neuroscience and Physics Departments of the Universities of Roma. The specific objective of DCMN Research Unit is the study of the physical-engineering aspects related to BNCT. The paper outlines the research lines in progress at DCMN: Monte Carlo calculations of neutron dose distribution for BNCT treatment planning; measurements of neutron fluxes, spectra and doses by neutron detectors specifically set up; design of modifications to the nuclear reactors of ENEA Casaccia Center. In particular, the paper emphasizes the most original contributions on dosimetric aspects, both from informatic and experimental points of view.(author)

  7. Improvement of neutron irradiation field of research reactors for BNCT

    International Nuclear Information System (INIS)

    Aizawa, Otohiko

    1992-01-01

    The modification of research reactors for an improvement of the irradiation field for BNCT has been investigated in comparison with the field characteristics of the 'old' configuration at the Musashi reactor. The new point of this study is that the evaluation has been done by using an arrangement including both the facility structure and a whole-body phantom, and also by considering the whole-body absorbed dose. (author)

  8. PBF/BNCT [power burst facility/boron neutron capture therapy] program for cancer treatment

    International Nuclear Information System (INIS)

    Dorn, R.V. III.

    1989-06-01

    Highlights of the PBF/BNCT Program during June include progress within the areas of gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; and analytical radiation transport and interaction modeling for BNCT

  9. Feasibility study to develop BNCT facility at the Indonesian research reactor

    International Nuclear Information System (INIS)

    Hastowo, H.

    2001-01-01

    A survey on the Indonesian research reactors and its supporting facilities has been done in order to check the possibility to install BNCT facility. Oncologists from several hospitals have been informing about the BNCT treatment for tumours and they give a positive response to support utilisation of the BNCT facility. Several aspects required to support the BNCT treatment have also been identified and related activities on that matter soon will be initiated. The interim result in our survey indicated that utilisation of the 30 MW Multipurpose reactor would not be possible from the technical point of view. Further study will be concentrated on the TRIGA reactor and an epithermal neutron beam facility at the thermal column of this reactor will be designed for further work. (author)

  10. The Idaho Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program overview

    International Nuclear Information System (INIS)

    Dorn, R.V. III; Griebenow, M.L.; Ackermann, A.L.; Miller, L.G.; Miller, D.L.; Wheeler, F.J.; Bradshaw, K.M.; Wessol, D.E.; Harker, Y.D.; Nigg, D.W.; Randolph, P.D.; Bauer, W.F.; Gavin, P.R.; Richards, T.L.

    1992-01-01

    The Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program has been funded since 1988 to evaluate brain tumor treatment using Na 2 B 12 H 11 SH (borocaptate sodium or BSH) and epithermal neutrons. The PBF/BNCT Program pursues this goal as a comprehensive, multidisciplinary, multiorganizational endeavor applying modern program management techniques. The initial focus was to: (1) establish a representative large animal model and (2) develop the generic analytical and measurement capabilities require to control treatment repeatability and determine critical treatment parameters independent of tumor type and body location. This paper will identify the PBF/BNCT Program elements and summarize the status of some of the developed capabilities

  11. Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor

    International Nuclear Information System (INIS)

    Castro, Vinicius Alexandre de

    2014-01-01

    Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)

  12. Reprint of Application of BNCT to the treatment of HER2+ breast cancer recurrences: Research and developments in Argentina

    International Nuclear Information System (INIS)

    Gadan, M.A.; González, S.J.; Batalla, M.; Olivera, M.S.; Policastro, L.; Sztejnberg, M.L.

    2015-01-01

    In the frame of the Argentine BNCT Project a new research line has been started to study the application of BNCT to the treatment of locoregional recurrences of HER2+ breast cancer subtype. Based on former studies, the strategy considers the use of immunoliposomes as boron carriers nanovehicles to target HER2 overexpressing cells. The essential concerns of the current stage of this proposal are the development of carriers that can improve the efficiency of delivery of boron compounds and the dosimetric assessment of treatment feasibility. For this purpose, an specific pool of clinical cases that can benefit from this application was determined. In this work, we present the proposal and the advances related to the different stages of current research. - Highlights: • A new proposal of BNCT for HER2+ breast cancer treatment is introduced. • The proposal considers development of immunoliposomes as boron carrier nanovehicles. • Locoregional recurrences after treatment were identified as candidates for initial BNCT studies. • First analysis show acceptable neutron flux distributions provided by RA-6 BNCT facility.

  13. Microwave digestion techniques applied to determination of boron by ICP-AES in BNCT program

    International Nuclear Information System (INIS)

    Farias, Silvia S.; Di Santo, Norberto R.; Garavaglia, Ricardo N.; Pucci, Gladys N.; Batistoni, Daniel A.; Schwint, Amanda E.

    1999-01-01

    Recently, boron neutron capture therapy (BNCT) has merged as an interesting option for the treatment of some kind of tumors where established therapies show no success. A molecular boronated species, enriched in 10 B is administrated to the subject; it localizes in malignant tissues depending the kind of tumor and localization. Therefore, a very important fact in BNCT research is the detection of boron at trace or ultra trace levels precisely and accurately. This is extremely necessary as boronated species do localize in tumoral tissue and also localize in liver, kidney, spleen, skin, membranes. By this way, before testing a boronated species, it is mandatory to determine its biodistribution in a statistically meaning population, that is related with managing of a great number of samples. In the other hand, it is necessary to exactly predict when to begin the irradiation and to determine the magnitude of radiation to obtain the desired radiological dose for a specified mean boron concentration. This involves the determination of boron in whole blood, which is related with boron concentration in the tumor object of treatment. The methodology selected for the analysis of boron in whole blood and tissues must join certain characteristics: it must not be dependant of the chemical form of boron, it has to be fast and capable to determine boron accurately and precisely in a wide range of concentrations. The design and validation of experimental models involving animals in BNCT studies and the determination of boron in blood of animals and subjects upon treatment require reliable analytical procedures to determine boron quantitatively in those biologic materials. Inductively coupled plasma-atomic emission spectrometry (ICP-AES) using pneumatic nebulization is one of the most promising methods for boron analysis, but the sample must be liquid and have low solid concentration. In our case, biological tissues and blood, it is mandatory to mineralize and/or dilute samples

  14. Tandem electrostatic accelerators for BNCT

    International Nuclear Information System (INIS)

    Ma, J.C.

    1994-01-01

    The development of boron neutron capture therapy (BNCT) into a viable therapeutic modality will depend, in part, on the availability of suitable neutron sources compatible with installation in a hospital environment. Low-energy accelerator-based intense neutron sources, using electrostatic or radio frequency quadrupole proton accelerators have been suggested for this purpose and are underdevelopment at several laboratories. New advances in tandem electrostatic accelerator technology now allow acceleration of the multi-milliampere proton beams required to produce therapeutic neutron fluxes for BNCT. The relatively compact size, low weight and high power efficiency of these machines make them particularly attractive for installation in a clinical or research facility. The authors will describe the limitations on ion beam current and available neutron flux from tandem accelerators relative to the requirements for BNCT research and therapy. Preliminary designs and shielding requirements for a tandern accelerator-based BNCT research facility will also be presented

  15. The Phase I/II BNCT Trials at the Brookhaven medical research reactor: Critical considerations

    International Nuclear Information System (INIS)

    Diaz, A.Z.

    2001-01-01

    A phase I/II clinical trial of boronophenylalanine-fructose (BPA-F) mediated boron neutron capture therapy (BNCT) for Glioblastoma Multiforme (GBM) was initiated at Brookhaven National Laboratory (BNL) in 1994. Many critical issues were considered during the design of the first of many sequential dose escalation protocols. These critical issues included patient selection criteria, boron delivery agent, dose limits to the normal brain, dose escalation schemes for both neutron exposure and boron dose, and fractionation. As the clinical protocols progressed and evaluation of the tolerance of the central nervous system (CNS) to BPA-mediated BNCT at the BMRR continued new specifications were adopted. Clinical data reflecting the progression of the protocols will be presented to illustrate the steps taken and the reasons behind their adoption. (author)

  16. Boron neutron capture therapy (BNCT) for glioblastoma multiforme using the epithermal neutron beam at the Brookhaven Medical Research Reactor

    International Nuclear Information System (INIS)

    Capala, J.; Diaz, A.Z.; Chadha, M.

    1997-01-01

    The abstract describes evaluation of boron neutron capture therapy (BNCT) for two groups of glioblastoma multiforme patients. From September 1994 to February 1996 15 patients have been treated. In September 1997 another 34 patients were examined. Authors determined a safe starting dose for BNCT using epithermal neutrons and BPA-F. They have also evaluated adverse effects of BNCT at this starting dose. Therapeutic effectiveness of this starting dose has been evaluated. No significant side effects from BPA-F infusion or BNCT treatment were observed in normal brains

  17. Boron neutron capture therapy (BNCT) for glioblastoma multiforme using the epithermal neutron beam at the Brookhaven Medical Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Capala, J. [Brookhaven National Lab., Upton, NY (United States); Diaz, A.Z.; Chadha, M. [Univ. Hospital, State Univ. of New York, NY (United States)] [and others

    1997-12-31

    The abstract describes evaluation of boron neutron capture therapy (BNCT) for two groups of glioblastoma multiforme patients. From September 1994 to February 1996 15 patients have been treated. In September 1997 another 34 patients were examined. Authors determined a safe starting dose for BNCT using epithermal neutrons and BPA-F. They have also evaluated adverse effects of BNCT at this starting dose. Therapeutic effectiveness of this starting dose has been evaluated. No significant side effects from BPA-F infusion or BNCT treatment were observed in normal brains.

  18. Radiation field characterization of a BNCT research facility using Monte Carlo method - code MCNP-4B

    International Nuclear Information System (INIS)

    Hernandez, Antonio Carlos

    2002-01-01

    Boron Neutron Capture Therapy - BNCT - is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an Am Be neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these Becton studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluencyN T = 1,35x10 8 n/cm , a fast neutron dose of 5,86x10 -10 Gy/N T and a gamma ray dose of 8,30x10 -14 Gy/N T . (author)

  19. Accelerator-based BNCT.

    Science.gov (United States)

    Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O

    2014-06-01

    The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. © 2013 Elsevier Ltd. All rights reserved.

  20. Development of An Epi-thermal Neutron Field for Fundamental Researches for BNCT with A DT Neutron Source

    Directory of Open Access Journals (Sweden)

    Osawa Yuta

    2017-01-01

    Full Text Available Boron Neutron Capture Therapy (BNCT is known to be a new promising cancer therapy suppressing influence against normal cells. In Japan, Accelerator Based Neutron Sources (ABNS are being developed for BNCT. For the spread of ABNS based BNCT, we should characterize the neutron field beforehand. For this purpose, we have been developing a low-energy neutron spectrometer based on 3He position sensitive proportional counter. In this study, a new intense epi-thermal neutron field was developed with a DT neutron source for verification of validity of the spectrometer. After the development, the neutron field characteristics were experimentally evaluated by using activation foils. As a result, we confirmed that an epi-thermal neutron field was successfully developed suppressing fast neutrons substantially. Thereafter, the neutron spectrometer was verified experimentally. In the verification, although a measured detection depth distribution agreed well with the calculated distribution by MCNP, the unfolded spectrum was significantly different from the calculated neutron spectrum due to contribution of the side neutron incidence. Therefore, we designed a new neutron collimator consisting of a polyethylene pre-collimator and boron carbide neutron absorber and confirmed numerically that it could suppress the side incident neutrons and shape the neutron flux to be like a pencil beam.

  1. Medical setup of intraoperative BNCT at JRR-4

    Energy Technology Data Exchange (ETDEWEB)

    Akutsu, H.; Yamamoto, T.; Matsumura, A. [Tsukuba Univ., Ibaraki (Japan)] [and others

    2000-10-01

    Since October 1999, we have been performing clinical trials of intraoperative boron neutron capture therapy (IOBNCT) using a mixed thermal-epithermal beam at the Japan Research Reactor No. 4 (JRR-4). For immediate pre-BNCT care, including administration of a boron compound as well as post-BNCT care, a collaborating neurosurgical department of the University of Tsukuba was prepared in the vicinity of JRR-4. Following craniotomy in the treatment room, anesthetized patients were transported into the irradiation room for BNCT. The boron concentration in tissue was measured by the PGA and ICP-AES methods. The long-term follow-up was done at the University of Tsukuba Hospital. IOBNCT is a complex clinical procedure, which requires sophisticated operating team and co-medical staffs and also cooperation with physicist team. IOBNCT is a complex clinical procedure requiring a high level of cooperation among the operating team, co-medical staff, and physicists. For the safe and successful performance of IOBNCT, we have made the program including critical pathway and prepared various equipments for IOBNCT. To ensure the safe and successful performance of IOBNCT, we developed a critical pathway for use during the procedure, and prepared various apparatus for IOBNCT. (author)

  2. BNCT Technology Development on HANARO Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ki Jung; Park, Kyung Bae; Whang, Seung Ryul; Kim, Myong Seop

    2007-06-15

    So as to establish the biological effects of BNCT in the HANARO Reactor, biological damages in cells and animals with treatment of boron/neutron were investigated. And 124I-BPA animal PET image, analysis technology of the boron contents in the mouse tissues by ICP-AES was established. A Standard clinical protocol, a toxicity evaluation report and an efficacy investigation report of BNCT has been developed. Based on these data, the primary permission of clinical application was acquired through IRB of our hospital. Three cases of pre-clinical experiment for boron distribution and two cases of medium-sized animal simulation experiment using cat with verifying for 2 months after BNCT was performed and so the clinical demonstration with a patient was prepared. Also neutron flux, fast neutron flux and gamma ray dose of BNCT facility were calculated and these data will be utilized good informations for clinical trials and further BNCT research. For the new synthesis of a boron compound, o-carboranyl ethylamine, o-carboranylenepiperidine, o-carboranyl-THIQ and o-carboranyl-s-triazine derivatives were synthesized. Among them, boron uptake in the cancer cell of the triazine derivative was about 25 times than that of BPA and so these three synthesized methods of new boron compounds were patented.

  3. BNCT Technology Development on HANARO Reactor

    International Nuclear Information System (INIS)

    Chun, Ki Jung; Park, Kyung Bae; Whang, Seung Ryul; Kim, Myong Seop

    2007-06-01

    So as to establish the biological effects of BNCT in the HANARO Reactor, biological damages in cells and animals with treatment of boron/neutron were investigated. And 124I-BPA animal PET image, analysis technology of the boron contents in the mouse tissues by ICP-AES was established. A Standard clinical protocol, a toxicity evaluation report and an efficacy investigation report of BNCT has been developed. Based on these data, the primary permission of clinical application was acquired through IRB of our hospital. Three cases of pre-clinical experiment for boron distribution and two cases of medium-sized animal simulation experiment using cat with verifying for 2 months after BNCT was performed and so the clinical demonstration with a patient was prepared. Also neutron flux, fast neutron flux and gamma ray dose of BNCT facility were calculated and these data will be utilized good informations for clinical trials and further BNCT research. For the new synthesis of a boron compound, o-carboranyl ethylamine, o-carboranylenepiperidine, o-carboranyl-THIQ and o-carboranyl-s-triazine derivatives were synthesized. Among them, boron uptake in the cancer cell of the triazine derivative was about 25 times than that of BPA and so these three synthesized methods of new boron compounds were patented

  4. The studsvik BNCT project: structure and the proposed protocols

    International Nuclear Information System (INIS)

    Capala, J.; Stenstam, B.H.; Skoeld, K.; Henriksson, R.; Salford, L.; Carlsson, J.

    2000-01-01

    The BNCT facility at Studsvik is now ready for clinical trials. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of all major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia and to assure the quality of the research. Proposed clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro-Oncology Group and, initially, will involve two protocols: Protocol no.1. BNCT for glioblastoma patients who have not received any therapy other than surgery (including stereotactic biopsy only). Protocol no.2. BNCT as a palliative treatment for patients with recurrent glioblastoma following conventional therapies or BNCT. In both protocols, BPA, administered by a 6 hour i.v. infusion, will be used as the boron delivery agent. (author)

  5. BNCT of canine osteosarcoma

    International Nuclear Information System (INIS)

    Mitin, V.N.; Kulakov, V.N.; Khokhlov, V.F.

    2006-01-01

    A dog was diagnosed with osteosarcoma (8x6x5cm) in the right wing of ilium by radiography, radionuclide scintigraphy and histological study of biopsy material. The treatment plan was as follows: γ-therapy in combination with chemotherapy; prevention of hematogenous pulmonary metastases by the transfusion of 130 ml of allogenic marrow from a healthy donor; administration of 11.4g 10 B-boronphenylalanine into the right iliac artery; resection of the right iliac wing with the osteosarcoma lesion; neutron irradiation (MEPhI Reactor) of the bone fragment (dose on healthy osteocytes - 15±4 Gy (W), on tumor - 50±9 Gy (W); reimplantation and fixation of the fragment; three courses of adjuvant chemotherapy. The doses were determined in full-scale calculations of the reactor radiation fields with a model of the bone under the code RADUGA. The 10 B concentration (μg/g) in the bone was: normal tissue - 9±3, tumor - 28±5. In 24 hours post operation the dog was able to walk using the treated limb, and 6 months later it moved freely. The patient has been under observation for 30 months. The results of the research demonstrate complete cure. The use of similar treatment plans improves the therapeutic efficiency of BNCT. (author)

  6. American brain tumor patients treated with BNCT in Japan

    International Nuclear Information System (INIS)

    Laramore, G.E.; Griffin, B.R.; Spence, A.

    1995-01-01

    The purpose of this work is to establish and maintain a database for patients from the United States who have received BNCT in Japan for malignant gliomas of the brain. This database will serve as a resource for the DOE to aid in decisions relating to BNCT research in the United States, as well as assisting the design and implementation of clinical trials of BNCT for brain cancer patients in this country. The database will also serve as an information resource for patients with brain tumors and their families who are considering this form of therapy

  7. Radiation field characterization of a BNCT research facility using Monte Carlo Method - Code MCNP-4B; Caracterizacao do campo de radiacao numa instalacao para pesquisa em BNCT o metodo de Monte Carlo Codigo - MCNP-4B

    Energy Technology Data Exchange (ETDEWEB)

    Hernandes, Antonio Carlos

    2002-07-01

    Boron Neutron Capture Therapy - BNCT- is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an AmBe neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these BNCT studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluency {Nu}{sub {Tau}} = 1,35x10{sup 8} n/cm{sup 2}, a fast neutron dose of 5,86x{sup -1}0 Gy/{Nu}{sub {Tau}} and a gamma ray dose of 8,30x{sup -14} Gy/{Nu}{sub {Tau}}. (author)

  8. Development of cancer therapy facility of HANARO and medical research in BNCT; development of the technique for boron concentration analysis

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hee Dong; Byun, Soo Hyun; Sun, Gwang Min; Kim, Suk Kwon; Kim, In Jung; Park, Chang Su [Seoul National University, Seoul (Korea)

    2002-03-01

    Objective and Necessity of the Project- Development of a boron concentration analysis facility used for BNCT. - Development of the technique for boron concentration analysis. Contents and Scopes of the Project - Construction of the boron concentration analysis facility based on PGAA. Estimation of the neutron beam characteristics. -Establishment of the technique for the boron concentration analysis. - Estimation of the reliability for the boron analysis. Results of the Project -Installation of the boron concentration analysis facility at Hanaro. - Neutron beam characteristics are the sample position (neutron flux : 7.9 x 10{sup 7} n/cm{sup 2}s, Cd-ratio : 266) Technique for the boron concentration analysis. - Boron detection sensitivity and limit (detection sensitivity : 2, 131 cps/mg-B, detection limit : 67 ng for 10,000 sec). 63 refs., 37 figs., 13 tabs. (Author)

  9. In vivo BNCT in experimental and spontaneous tumors at RA-1 reactor

    International Nuclear Information System (INIS)

    Trivillin, Veronica A.; Heber, Elisa M.; Itoiz, Maria E.; Schwint, Amanda E.; Nigg, David W.

    2003-01-01

    Within the search for new applications of Boron Neutron Capture Therapy (BNCT) and the basic research oriented towards the study of BNCT radiobiology to optimize its therapeutic gain, we previously proposed and validated the hamster cheek pouch oral cancer model and showed, for the first time, the success of BNCT to treat oral cancer in an experimental model. The staff of the Ra-1 Reactor (Constituyentes Atomic Center) adapted the thermal beam and physical set-up to perform in vivo BNCT of superficial tumors in small animals. We preformed a preliminary characterization of the thermal beam, performed beam only irradiation of normal and tumor bearing hamsters and in vivo BNCT of experimental oral squamous cell carcinomas in hamsters mediated by boron phenylalanine (BPA) and GB-10 (Na 2 10 B 10 H 10 ). Having demonstrated the absence of radio toxic effects in healthy tissue and a therapeutic effect of in vivo BNCT in hamster cheek pouch tumors employing the Ra-1 thermal beam, we performed a feasibility study of the treatment by BNCT of 3 terminal cases of spontaneous head and neck squamous cell carcinoma in cats following the corresponding biodistribution studies. This was the first treatment of spontaneous tumors by BNCT in our country and the first treatment by BNCT in cats worldwide. This preclinical study in terminal cases showed significant tumor control by BNCT with no damage to normal tissue. (author)

  10. An update on the clinical trial of BNCT at the BMRR

    International Nuclear Information System (INIS)

    Ma, R.; Capala, J.; Chanana, A.D.; Coderre, J.A.; Diaz, A.Z.

    1999-01-01

    Boron neutron capture therapy (BNCT) was proposed more than six decades ago. It is a binary treatment modality that requires selective delivery of a 10 B-labeled compound to a tumor and slow neutron irradiation of the tumor-bearing tissues. In order to improve the penetration of the neutron beam, an epithermal neutron beam was developed at the Brookhaven Medical Research Reactor (BMRR). This epithermal neutron beam can deliver relatively high thermal neutron fluence at depth without severe skin damage. Boronophenylalanine-fructose (BPA-F), a nontoxic boron carrier, was found to preferentially accumulate in tumor cells following intravenous infusion in patients with GBM. In preclinical BNCT studies in rats bearing 9L gliosarcoma, BPA-mediated BNCT was shown to be more efficacious than photon irradiation. In 1994, improvements in the neutron beam and in the understanding of the radiobiology of BPA-mediated BNCT led to the initiation of BNCT trials for human GBM at BMRR using BPA-F and epithermal neutrons. The primary objective of the phase I/II clinical trial of BPA-mediated BNCT at BMRR is to evaluate the safety of the BPA-F-mediated BNCT using epithermal neutrons in patients with GBM at a series of escalating BNCT doses. An incidental objective is to evaluate the therapeutic effectiveness of BNCT at each dose level. For each dose escalation group, the average brain dose (ABD) is escalated, as well as the minimum tumor dose. In summary, the BNCT procedure employed in the phase I/II clinical trial of BPA-F-mediated BNCT for GBM at BNL was found to be safe in all patients. The palliation afforded by a single session of BNCT compares favorably with palliation provided by fractionated photon therapy and adjuvant chemotherapy. If no evidence of radiation-induced brain toxicity is found in the current protocol, BNCT radiation dose will be further escalated

  11. Radiation field characterization of a BNCT research facility using Monte Carlo method - code MCNP-4B; Caracterizacao do campo de radiacao numa instalacao para pesquisa em BNCT utilizando o metodo de Monte Carlo - codigo MCNP-4B

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez, Antonio Carlos

    2002-07-01

    Boron Neutron Capture Therapy - BNCT - is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an Am Be neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these Becton studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluencyN{sub T} = 1,35x10{sup 8} n/cm , a fast neutron dose of 5,86x10{sup -10} Gy/N{sub T} and a gamma ray dose of 8,30x10{sup -14} Gy/N{sub T}. (author)

  12. SERA -- An advanced treatment planning system for neutron therapy and BNCT

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wemple, C.A.; Wessol, D.E.; Wheeler, F.J.; Albright, C.; Cohen, M.; Frandsen, M.; Harkin, G.; Rossmeier, M.

    1999-01-01

    Detailed treatment planning calculations on a patient-specific basis are required for boron neutron capture therapy (BNCT). Two integrated treatment planning systems developed specifically for BNCT have been in clinical use in the United States over the past few years. The MacNCTPLAN BNCT treatment planning system is used in the clinical BNCT trials that are underway at the Massachusetts Institute of Technology. A second system, BNCT rtpe (BNCT radiation therapy planning environment), developed independently by the Idaho national Engineering and Environmental Laboratory (INEEL) in collaboration with Montana State University (MSU), is used for treatment planning in the current series of BNCT clinical trials for glioblastoma at Brookhaven National Laboratory (BNL). This latter system is also licensed for use at several other BNCT research facilities worldwide. Although the currently available BNCT planning systems have served their purpose well, they suffer from somewhat long computation times (2 to 3 CPU-hours or more per field) relative to standard photon therapy planning software. This is largely due to the need for explicit three-dimensional solutions to the relevant transport equations. The simplifying approximations that work well for photon transport computations are not generally applicable to neutron transport computations. Greater computational speeds for BNCT treatment planning must therefore generally be achieved through the application of improved numerical techniques rather than by simplification of the governing equations. Recent efforts at INEEL and MSU have been directed toward this goal. This has resulted in a new paradigm for this type of calculation and the subsequent creation of the new simulation environment for radiotherapy applications (SERA) treatment planning system for BNCT. SERA is currently in initial clinical testing in connection with the trials at BNL, and it is expected to replace the present BNCT rtpe system upon general release

  13. Proceedings of neutron irradiation technical meeting on BNCT

    International Nuclear Information System (INIS)

    2000-10-01

    The 'Neutron Irradiation Technical Meeting for Boron Neutron Capture Therapy (BNCT)' was held on March 13, 2000 at Tokai Research Establishment. The Meeting is aimed to introduce the neutron beam facility for medical irradiation at JRR-4 to Japanese researchers widely, as well as providing an opportunity for young researchers, engineers, medical representatives such surgeons and doctors of pharmacology to present their research activities and to exchange valuable information. JAERI researcher presented the performance and the irradiation technology in the JRR-4 neutron beam facility, while external researchers made various and beneficial presentations containing such accelerator-based BNCT, spectrum-shifter, biological effect, pharmacological development and so on. In this meeting, a special lecture titled 'The Dawn of BNCT and Its Development.' was given by MD, Prof. Takashi Minobe, an executive director of Japan Foundation for Emergency Medicine. The 11 of the presented papers are indexed individually. (J.P.N.)

  14. Proceedings of neutron irradiation technical meeting on BNCT

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    The 'Neutron Irradiation Technical Meeting for Boron Neutron Capture Therapy (BNCT)' was held on March 13, 2000 at Tokai Research Establishment. The Meeting is aimed to introduce the neutron beam facility for medical irradiation at JRR-4 to Japanese researchers widely, as well as providing an opportunity for young researchers, engineers, medical representatives such surgeons and doctors of pharmacology to present their research activities and to exchange valuable information. JAERI researcher presented the performance and the irradiation technology in the JRR-4 neutron beam facility, while external researchers made various and beneficial presentations containing such accelerator-based BNCT, spectrum-shifter, biological effect, pharmacological development and so on. In this meeting, a special lecture titled 'The Dawn of BNCT and Its Development.' was given by MD, Prof. Takashi Minobe, an executive director of Japan Foundation for Emergency Medicine. The 11 of the presented papers are indexed individually. (J.P.N.)

  15. Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

    OpenAIRE

    Akan, Zafer; Demiroglu, Hasan; Avcibasi, Ugur; Oto, Gokhan; Ozdemir, Hulya; Deniz, Sabahattin; Basak, Ali Sadi

    2014-01-01

    Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching fo...

  16. BNCT irradiation facility at the JRR-4

    International Nuclear Information System (INIS)

    Torii, Y.; Kishi, T.; Kumada, H.; Yamamoto, K.; Sakurai, F.; Takayanagi, M.

    2000-01-01

    The JRR--4 was modified for fuel enrichment reducing and reactor equipment renewal. And also a medical irradiation facility for the Boron Neutron Capture Therapy (BNCT) was installed at the JRR--4 in that time. The medical irradiation facility has been composed of a heavy water tank, a collimator and an irradiation room. The heavy water tank has four layers of heavy water for spectrum shifter and 75cm-thickness aluminum for the shield of fast neutron. The collimator is for collimating thermal neutron and epithermal neutron using polyethylene with lithium-fluoride and shielding gamma ray by bismuth. The irradiation room has sufficient space at exit side of the beam, to accommodate a large working area for setting the patient. Both of the medical treatment room and the patient-monitoring area were prepared adjacent to the irradiation room. The medical irradiation facility in the JRR-4 is designed to permit selection of neutron energies from thermal neutron to epithermal neutron by changing the thickness of heavy water layers. Therefore it is available to continue the same kind of BNCT with thermal neutron used to perform in the JRR-2, as well as to commence the research and development of BNCT with epithermal neutron, which will make the brain tumor treatment possible at a deep part of brain. The full power operation of the JRR-4 was resumed with LEU fuel in October 1998 and currently performing some experiments to measure the neutron fluxes and physical doses for determinate characterization of the medical irradiation facility. The first medical irradiation for BNCT was carried out on 25th October 1999. The patient was treated by Tsukuba University group using thermal neutron beam included epi-thermal neutrons. (author)

  17. BNCT irradiation facility at the JRR-4

    Energy Technology Data Exchange (ETDEWEB)

    Torii, Y.; Kishi, T.; Kumada, H.; Yamamoto, K.; Sakurai, F.; Takayanagi, M. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2000-10-01

    The JRR--4 was modified for fuel enrichment reducing and reactor equipment renewal. And also a medical irradiation facility for the Boron Neutron Capture Therapy (BNCT) was installed at the JRR--4 in that time. The medical irradiation facility has been composed of a heavy water tank, a collimator and an irradiation room. The heavy water tank has four layers of heavy water for spectrum shifter and 75cm-thickness aluminum for the shield of fast neutron. The collimator is for collimating thermal neutron and epithermal neutron using polyethylene with lithium-fluoride and shielding gamma ray by bismuth. The irradiation room has sufficient space at exit side of the beam, to accommodate a large working area for setting the patient. Both of the medical treatment room and the patient-monitoring area were prepared adjacent to the irradiation room. The medical irradiation facility in the JRR-4 is designed to permit selection of neutron energies from thermal neutron to epithermal neutron by changing the thickness of heavy water layers. Therefore it is available to continue the same kind of BNCT with thermal neutron used to perform in the JRR-2, as well as to commence the research and development of BNCT with epithermal neutron, which will make the brain tumor treatment possible at a deep part of brain. The full power operation of the JRR-4 was resumed with LEU fuel in October 1998 and currently performing some experiments to measure the neutron fluxes and physical doses for determinate characterization of the medical irradiation facility. The first medical irradiation for BNCT was carried out on 25th October 1999. The patient was treated by Tsukuba University group using thermal neutron beam included epi-thermal neutrons. (author)

  18. Building of scientific information system for sustainable development of BNCT in Bulgaria

    International Nuclear Information System (INIS)

    Mitev, M.; Ilieva, K.; Apostolov, T.

    2009-01-01

    Building a boron neutron capture therapy (BNCT) facility is foreseen within the reconstruction of the Research Reactor IRT (IRT) of the Institute for Nuclear Research and Nuclear Energy of the Bulgaria Academy of Sciences (INRNE). The development of BNCT at IRT plays a very significant role in the plan for sustainable application of the reactor. A centralized scientific information system on BNCT is being built at the INRNE with the purpose to collect and sort new information as knowledge accumulated during more than thirty years history of BNCT. This BNCT information system will help the creation and consolidation of a well informed and interconnected interdisciplinary team of physicists, chemists, biologists, and radio-oncologists for establishing BNCT cancer treatment in Bulgaria. It will strengthen more intensive development of the national network as well as its enlargement to the Balkan region countries. Furthermore, to acquaint the public at large with the opportunity for BNCT cancer treatment will be addressed. Human, social, and economics results due to BNCT for many patients from Balkan region are expected.

  19. Correlation of clinical outcome to the estimated radiation dose from Boron Neutron Capture Therapy (BNCT)

    Energy Technology Data Exchange (ETDEWEB)

    Chadha, M. [Beth Israel Medical Center, NY (United States). Dept. of Radiation Oncology; Coderre, J.A.; Chanana, A.D. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-12-31

    A phase I/II trial delivering a single fraction of BNCT using p-Boronophenylalanine-Fructose and epithermal neutrons at the the Brookhaven Medical Research Reactor was initiated in September 1994. The primary endpiont of the study was to evaluate the feasibility and safety of a given BNCT dose. The clinical outcome of the disease was a secondary endpoint of the study. The objective of this paper is to evaluate the correlation of the clinical outcome of patients to the estimated radiation dose from BNCT.

  20. Correlation of clinical outcome to the estimated radiation dose from Boron Neutron Capture Therapy (BNCT)

    International Nuclear Information System (INIS)

    Chadha, M.

    1996-01-01

    A phase I/II trial delivering a single fraction of BNCT using p-Boronophenylalanine-Fructose and epithermal neutrons at the the Brookhaven Medical Research Reactor was initiated in September 1994. The primary endpiont of the study was to evaluate the feasibility and safety of a given BNCT dose. The clinical outcome of the disease was a secondary endpoint of the study. The objective of this paper is to evaluate the correlation of the clinical outcome of patients to the estimated radiation dose from BNCT

  1. Successful BNCT for patients with cutaneous and mucosal melanomas. Report of 4 cases

    International Nuclear Information System (INIS)

    Morita, Norimasa; Hiratsuka, Junichi; Kuwabara, Chiaki; Aihara, Teruhito; Harada, Tamotsu; Imajo, Yoshinari; Ono, Koji; Fukuda, Hiroshi; Kumada, Hiroaki

    2006-01-01

    Since 2003 we have conducted BNCT clinical trials on melanomas at the Kyoto University Research Reactor (KUR) and Japan Research Reactor No.4 (JRR-4). We report 4 patients given BNCT for malignant melanomas: 2 with superficial spreading types on the heel, 1 with mucosal melanoma in the nasal cavity, and 1 with a melanoma on the vulva and in the vagina. The two cutaneous melanomas and the nasal cavity mucosal melanoma showed a complete response (CR) by 6 months after BNCT. The residual melanoma showed a partial response (PR) by 3 months after treatment and no regrowth since then. Although two patients experienced normal-tissue damage that exceeded the tolerance level, all the participants were cured within a few months of treatment. BNCT was shown to be a promising treatment for mucosal, as well as for cutaneous, melanomas. (author)

  2. Energy research program 85

    International Nuclear Information System (INIS)

    1985-01-01

    The energy research program 85 (EFP-85) is prepared by the Danish Ministry of Energy in order to continue the extension of the Danish energy research and development started through the former Trade Ministry's programs EM-1 (1976) and EM-2 (1978), and Ministry of Energy's programs EFP-80, EFP-81, EFP-82, EFP-83, and EFP-84. The new program is a continuation of the activities in the period 1985-87 with a total budget of 110 mio. DKK. The program gives a brief description of background, principles, organization and financing, and a detailed description of each research area. (ln)

  3. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  4. BNCT with linac, feasibility study

    International Nuclear Information System (INIS)

    Alfuraih, A.; Ma, A.; Spyrou, N.M.; Awotwi-Pratt, Joseph

    2006-01-01

    High energy photon beams from Medical Linear Accelerators (linacs) which are used in radiotherapy produce undesirable neutrons, beside the clinically useful electron and photon beams. Neutrons are produced from the photonuclear reaction (γ,n) of high energy photons with high Z-materials which compose the accelerator head. In this paper the possible use of these undesirable neutrons for BNCT is investigated, making use of high energy linacs already installed in hospitals, primarily for high energy electron and photon therapy and applying them in the context of BNCT. The photoneutron components emitted by the accelerator is the source for Monte Carlo simulations of the interactions that take place within the head of a voxel-based phantom. The neutron flux across the phantom head is calculated using different moderator arrangements and different techniques in the aim of increasing the thermal neutron flux at the targeted site. Also, we shall test different configurations of the linac head to maximize the exposure of high-Z materials to the photon beam, including the removal of the flattening filter, so as to boost the photoneutron production in the linac head. Experimental work will be conducted in hospitals to validate the Monte Carlo simulations. To make use of linacs for BNCT will be advantageous in the sense that the setting in a hospital department is much more acceptable by the public than a reactor installation. This will mean less complications regarding patient positioning and movement with respect to the beams, additional patient transportation and management will be more cost effective. (author)

  5. Piping research program plan

    International Nuclear Information System (INIS)

    1988-09-01

    This document presents the piping research program plan for the Structural and Seismic Engineering Branch and the Materials Engineering Branch of the Division of Engineering, Office of Nuclear Regulatory Research. The plan describes the research to be performed in the areas of piping design criteria, environmentally assisted cracking, pipe fracture, and leak detection and leak rate estimation. The piping research program addresses the regulatory issues regarding piping design and piping integrity facing the NRC today and in the foreseeable future. The plan discusses the regulatory issues and needs for the research, the objectives, key aspects, and schedule for each research project, or group of projects focussing of a specific topic, and, finally, the integration of the research areas into the regulatory process is described. The plan presents a snap-shot of the piping research program as it exists today. However, the program plan will change as the regulatory issues and needs change. Consequently, this document will be revised on a bi-annual basis to reflect the changes in the piping research program. (author)

  6. Synthesis and in-vivo detection of boronated compounds for use in BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Kabalka, G.W.

    1992-01-01

    The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The UT-DOE program is unique in that it has access to both state-of-the-art whole-body and microscopy MRI instruments.

  7. Measurement and simulation of the TRR BNCT beam parameters

    Energy Technology Data Exchange (ETDEWEB)

    Bavarnegin, Elham [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Sadremomtaz, Alireza [Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Khalafi, Hossein [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Kasesaz, Yaser, E-mail: ykasesaz@aeoi.org.ir [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Golshanian, Mohadeseh; Ghods, Hossein; Ezzati, Arsalan; Keyvani, Mehdi; Haddadi, Mohammad [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of)

    2016-09-11

    Recently, the configuration of the Tehran Research Reactor (TRR) thermal column has been modified and a proper thermal neutron beam for preclinical Boron Neutron Capture Therapy (BNCT) has been obtained. In this study, simulations and experimental measurements have been carried out to identify the BNCT beam parameters including the beam uniformity, the distribution of the thermal neutron dose, boron dose, gamma dose in a phantom and also the Therapeutic Gain (TG). To do this, the entire TRR structure including the reactor core, pool, the thermal column and beam tubes have been modeled using MCNPX Monte Carlo code. To measure in-phantom dose distribution a special head phantom has been constructed and foil activation techniques and TLD700 dosimeter have been used. The results show that there is enough uniformity in TRR thermal BNCT beam. TG parameter has the maximum value of 5.7 at the depth of 1 cm from the surface of the phantom, confirming that TRR thermal neutron beam has potential for being used in treatment of superficial brain tumors. For the purpose of a clinical trial, more modifications need to be done at the reactor, as, for example design, and construction of a treatment room at the beam exit which is our plan for future. To date, this beam is usable for biological studies and animal trials. There is a relatively good agreement between simulation and measurement especially within a diameter of 10 cm which is the dimension of usual BNCT beam ports. This relatively good agreement enables a more precise prediction of the irradiation conditions needed for future experiments.

  8. Clinical results of BNCT for malignant meningiomas

    International Nuclear Information System (INIS)

    Miyatake, Shin-ichi; Tamura, Yoji; Kawabata, Shinji

    2006-01-01

    Malignant meningiomas is difficult pathology to be controlled as well as GBM. Since June of 2005, we applied BNCT for 7 cases of malignancy related meningiomas with 13 times neutron irradiation. Five were anaplastic, one was atypical meningiomas and one was sarcoma transformed from meningioma with cervical lymph node metastasis. All cases were introduced after repetitive surgeries and XRT or SRS. Follow-up images were available for 6 cases with observation duration between 2 to 9 months. We applied F-BPA-PET before BNCT in 6 out of 7 cases. One case was received methionine-PET. Five out of 6 cases who received BPA-PET study showed good BPA uptake more than 3 of T/N ratio. One atypical meningiomas cases showed 2.0 of T/N ratio. Original tumor sizes were between 9.2 to 92.7 ml. Two out of 5 anaplastic meningiomas showed CR and all six cases showed radiographic improvements. Clinical symptoms before BNCT such as hemiparesis and facial pain were improved after BNCT, except one case. An huge atypical meningiomas which arisen from tentorium and extended bilateral occipital lobes and brain stem, visual problems were worsened after repetitive BNCT with increase of peritumoral edema. Malignant meningiomas are seemed to be good candidate for BNCT. (author)

  9. Controlled thermonuclear research program

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    The Plasma Physics and Controlled-Fusion Research Program at the Lawrence Berkeley Laboratory is divided into five projects: Plasma Production and Heating Experiments, Plasma Theory, Atomic Physics Studies, the Tormac Project, and Neutral-Beam Development and Technology listed in order of increasing magnitude, as regards manpower and budget. Some cross sections and yields are shown in atomic physics

  10. SU-E-J-100: Reconstruction of Prompt Gamma Ray Three Dimensional SPECT Image From Boron Neutron Capture Therapy(BNCT)

    International Nuclear Information System (INIS)

    Yoon, D; Jung, J; Suh, T

    2014-01-01

    Purpose: Purpose of paper is to confirm the feasibility of acquisition of three dimensional single photon emission computed tomography (SPECT) image from boron neutron capture therapy (BNCT) using Monte Carlo simulation. Methods: In case of simulation, the pixelated SPECT detector, collimator and phantom were simulated using Monte Carlo n particle extended (MCNPX) simulation tool. A thermal neutron source (<1 eV) was used to react with the boron uptake region (BUR) in the phantom. Each geometry had a spherical pattern, and three different BURs (A, B and C region, density: 2.08 g/cm3) were located in the middle of the brain phantom. The data from 128 projections for each sorting process were used to achieve image reconstruction. The ordered subset expectation maximization (OSEM) reconstruction algorithm was used to obtain a tomographic image with eight subsets and five iterations. The receiver operating characteristic (ROC) curve analysis was used to evaluate the geometric accuracy of reconstructed image. Results: The OSEM image was compared with the original phantom pattern image. The area under the curve (AUC) was calculated as the gross area under each ROC curve. The three calculated AUC values were 0.738 (A region), 0.623 (B region), and 0.817 (C region). The differences between length of centers of two boron regions and distance of maximum count points were 0.3 cm, 1.6 cm and 1.4 cm. Conclusion: The possibility of extracting a 3D BNCT SPECT image was confirmed using the Monte Carlo simulation and OSEM algorithm. The prospects for obtaining an actual BNCT SPECT image were estimated from the quality of the simulated image and the simulation conditions. When multiple tumor region should be treated using the BNCT, a reasonable model to determine how many useful images can be obtained from the SPECT could be provided to the BNCT facilities. This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research

  11. Reactor Safety Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Edler, S. K.

    1981-07-01

    This document summarizes the work performed by Pacific Northwest Laboratory (PNL) from January 1 through March 31, 1981, for the Division of Reactor Safety Research within the U.S. Nuclear Regulatory Commission (NRC). Evaluations of nondestructive examination (NDE) techniques and instrumentation are reported; areas of investigation include demonstrating the feasibility of determining the strength of structural graphite, evaluating the feasibility of detecting and analyzing flaw growth in reactor pressure boundary systems, examining NDE reliability and probabilistic fracture mechanics, and assessing the integrity of pressurized water reactor (PWR) steam generator tubes where service-induced degradation has been indicated. Experimental data and analytical models are being provided to aid in decision-making regarding pipeto- pipe impacts following postulated breaks in high-energy fluid system piping. Core thermal models are being developed to provide better digital codes to compute the behavior of full-scale reactor systems under postulated accident conditions. Fuel assemblies and analytical support are being provided for experimental programs at other facilities. These programs include loss-ofcoolant accident (LOCA) simulation tests at the NRU reactor, Chalk River, Canada; fuel rod deformation, severe fuel damage, and postaccident coolability tests for the ESSOR reactor Super Sara Test Program, Ispra, Italy; the instrumented fuel assembly irradiation program at Halden, Norway; and experimental programs at the Power Burst Facility, Idaho National Engineering Laboratory (INEL). These programs will provide data for computer modeling of reactor system and fuel performance during various abnormal operating conditions.

  12. Wood pellet research program

    International Nuclear Information System (INIS)

    Sohkansanj, S.; Bi, T.

    2006-01-01

    Wood pellets are composed of waste wood materials such as sawmill residue, municipal landfill waste and grain crops. Due to the high temperature combustion used to form the waste materials into the pellet, no additives or glues are necessary to bind them. The pellets are typically used for home heating; heat and power production; poultry bedding; and in biorefineries. This presentation provided an outline of the University of British Columbia wood pellet research and development program. Research at the university is being conducted to develop new types of pellets. Researchers at the program also analyze the physical and chemical properties of pellets in order to optimize pellet density and heating values. Wood pellet modelling and simulation studies are carried out, and various training and education programs are also offered. Research is currently being conducted to develop a reactor for off-gassing experiments. This presentation also provided details of a study investigating the economics of wood pellet production and transport. Pellet production costs and feedstock costs were compared. A summary of the costs and energy inputs of pellet production included details of product storage; transportation and transfer; handling; and transportation to energy plants. It was concluded that more than 35 per cent of the energy content of biomass is used up in the processing and transport of Canadian wood pellets to Europe. refs., tabs., figs

  13. Accelerator based-boron neutron capture therapy (BNCT)-clinical QA and QC

    International Nuclear Information System (INIS)

    Suzuki, Minoru; Tanaka, Hiroki; Sakurai, Yoshinori; Yong, Liu; Kashino, Genro; Kinashi, Yuko; Masunaga, Shinichiro; Ono, Koji; Maruhashi, Akira

    2009-01-01

    Alpha-particle and recoil Li atom yielded by the reaction ( 10 B, n), due to their high LET properties, efficiently and specifically kill the cancer cell that has incorporated the boron. Efficacy of this boron neutron capture therapy (BNCT) has been demonstrated mainly in the treatment of recurrent head/neck and malignant brain cancers in Kyoto University Research Reactor Institute (KUR). As the clinical trial of BNCT is to start from 2009 based on an accelerator (not on the Reactor), this paper describes the tentative outline of the standard operation procedure of BNCT for its quality assurance (QA) and quality control (QC) along the flow of its clinical practice. Personnel concerned in the practice involve the attending physician, multiple physicians in charge of BNCT, medical physicists, nurses and reactor stuff. The flow order of the actual BNCT is as follows: Pre-therapeutic evaluation mainly including informed consent and confirmation of the prescription; Therapeutic planning including setting of therapy volume, and of irradiation axes followed by meeting for stuffs' agreement, decision of irradiating field in the irradiation room leading to final decision of the axis, CT for the planning, decision of the final therapeutic plan according to Japan Atomic Energy Agency-Computational Dosimetry System (JCDS) and meeting of all related personnel for the final confirmation of therapeutic plan; and BNCT including the transport of patient to KUR, dripping of boronophenylalanine, setting up of the patient on the machine, blood sampling for pharmacokinetics, boron level measurement for decision of irradiating time, switch on/off of the accelerator, confirmation of patient's movement in the irradiated field after the neutron irradiation, blood sampling for confirmation of the boron level, and patient's leave from the room. The QA/QC check is principally to be conducted with the two-person rule. The purpose of the clinical trial is to establish the usefulness of BNCT

  14. Sandia Combustion Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, S.C.; Palmer, R.E.; Montana, C.A. (eds.)

    1988-01-01

    During the late 1970s, in response to a national energy crisis, Sandia proposed to the US Department of Energy (DOE) a new, ambitious program in combustion research. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''user facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative-involving US inventories, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions several research projects which have been simulated by working groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship program, supported through the Office of Energy Research, has been instrumental in the success of some of these joint efforts. The remainder of this report presents results of calendar year 1988, separated thematically into eleven categories. Referred journal articles appearing in print during 1988 and selected other publications are included at the end of Section 11. Our traditional'' research activities--combustion chemistry, reacting flows, diagnostics, engine and coal combustion--have been supplemented by a new effort aimed at understanding combustion-related issues in the management of toxic and hazardous materials.

  15. Fermilab research program workbook

    International Nuclear Information System (INIS)

    Rubinstein, R.

    1983-05-01

    The Fermilab Research Program Workbook has been produced annually for the past several years, with the original motivation of assisting the Physics Advisory Committee in its yearly program review conducted during its summer meeting. While this is still the primary goal, the Workbook is increasingly used by others needing information on the current status of Fermilab experiments, properties of beams, and short summaries of approved experiments. At the present time, considerable changes are taking place in the facilities at Fermilab. We have come to the end of the physics program using the 400 GeV Main Ring, which is now relegated to be just an injector for the soon-to-be commissioned Tevatron. In addition, the experimental areas are in the midst of a several-year program of upgrading to 1000 GeV capability. Several new beam lines will be built in the next few years; some indications can be given of their properties, although with the caveat that designs for some are by no means final. Already there is considerable activity leading to experiments studying anti p p collisions at √s = 2000 GeV

  16. HTGR safety research program

    International Nuclear Information System (INIS)

    Barsell, A.W.; Olsen, B.E.; Silady, F.A.

    1981-01-01

    An HTGR safety research program is being performed supporting and guided in priorities by the AIPA Probabilistic Risk Study. Analytical and experimental studies have been conducted in four general areas where modeling or data assumptions contribute to large uncertainties in the consequence assessments and thus, in the risk assessment for key core heat-up accident scenarios. Experimental data have been obtained on time-dependent release of fission products from the fuel particles, and plateout characteristics of condensible fission products in the primary circuit. Potential failure modes of primarily top head PCRV components as well as concrete degradation processes have been analyzed using a series of newly developed models and interlinked computer programs. Containment phenomena, including fission product deposition and potential flammability of liberated combustible gases have been studied analytically. Lastly, the behaviour of boron control material in the core and reactor subcriticality during core heatup have been examined analytically. Research in these areas has formed the basis for consequence updates in GA-A15000. Systematic derivation of future safety research priorities is also discussed. (author)

  17. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  18. Study of the potential of using 9B(p,n) for BNCT clinical trials

    International Nuclear Information System (INIS)

    Stone, N.; Bleuel, D.; Donahue, R.; Ludewigt, B.A.; Chu, W.T.

    2000-01-01

    The potential of using a 30-MeV proton accelerator utilizing the 9 Be(p,n) 9 B reaction as a neutron source for BNCT (Boron Neutron Capture Therapy) was investigated. MCNPX (Monte Carlo Neutron Photon-transport code X) was used to calculated neutron spectra and yields for comparison against existing experimental data and for the moderator optimization. Moderator performance was assessed using MCNPX and clinical efficacy was assessed using BNCT-RTPE to estimate in-phantom dose distributions and neutron fluences. The optimized source and moderator gave comparable tumor doses and treatment times to the clinical trials recently completed at the Brookhaven Medical Research Reactor (BMRR). (author)

  19. Jointly Sponsored Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett A. Sondreal; John G. Hendrikson; Thomas A. Erickson

    2009-03-31

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC26-98FT40321 funded through the Office of Fossil Energy and administered at the National Energy Technology Laboratory (NETL) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy & Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying highly efficient, nonpolluting energy systems that meet the nation's requirements for clean fuels, chemicals, and electricity in the 21st century. The EERC in partnership with its nonfederal partners jointly performed 131 JSRP projects for which the total DOE cost share was $22,716,634 (38%) and the nonfederal share was $36,776,573 (62%). Summaries of these projects are presented in this report for six program areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, and (6) advanced materials. The work performed under this agreement addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration; near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources.

  20. Production of epithermal neutron beams for BNCT

    CERN Document Server

    Bisceglie, E; Colonna, N; Paticchio, V; Santorelli, P; Variale, V

    2002-01-01

    The use of boron neutron capture therapy (BNCT) for the treatment of deep-seated tumors requires neutron beams of suitable energy and intensity. Simulations indicate the optimal energy to reside in the epithermal region, in particular between 1 and 10 keV. Therapeutic neutron beams with high spectral purity in this energy range could be produced with accelerator-based neutron sources through a suitable neutron-producing reaction. Herein, we report on different solutions that have been investigated as possible sources of epithermal neutron beams for BNCT. The potential use of such sources for a hospital-based therapeutic facility is discussed.

  1. Component fragility research program

    International Nuclear Information System (INIS)

    Tsai, N.C.; Mochizuki, G.L.; Holman, G.S.

    1989-11-01

    To demonstrate how ''high-level'' qualification test data can be used to estimate the ultimate seismic capacity of nuclear power plant equipment, we assessed in detail various electrical components tested by the Pacific Gas ampersand Electric Company for its Diablo Canyon plant. As part of our Phase I Component Fragility Research Program, we evaluated seismic fragility for five Diablo Canyon components: medium-voltage (4kV) switchgear; safeguard relay board; emergency light battery pack; potential transformer; and station battery and racks. This report discusses our Phase II fragility evaluation of a single Westinghouse Type W motor control center column, a fan cooler motor controller, and three local starters at the Diablo Canyon nuclear power plant. These components were seismically qualified by means of biaxial random motion tests on a shaker table, and the test response spectra formed the basis for the estimate of the seismic capacity of the components. The seismic capacity of each component is referenced to the zero period acceleration (ZPA) and, in our Phase II study only, to the average spectral acceleration (ASA) of the motion at its base. For the motor control center, the seismic capacity was compared to the capacity of a Westinghouse Five-Star MCC subjected to actual fragility tests by LLNL during the Phase I Component Fragility Research Program, and to generic capacities developed by the Brookhaven National Laboratory for motor control center. Except for the medium-voltage switchgear, all of the components considered in both our Phase I and Phase II evaluations were qualified in their standard commercial configurations or with only relatively minor modifications such as top bracing of cabinets. 8 refs., 67 figs., 7 tabs

  2. Introducing BNCT treatment in new treatment facilities

    International Nuclear Information System (INIS)

    Gabel, D.

    2001-01-01

    The physical and radiobiological studies that should be performed before the initiation of BNCT are discussed. The need for dose-escalation versus response studies in large animal models is questioned. These studies are time consuming, expensive and legally difficult in some countries and may be dispensable. (author)

  3. Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

    International Nuclear Information System (INIS)

    Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, H.

    2011-01-01

    The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998. The median survival time (MST) of BNCT was 19.5 months, and 2-year, 3-year and 5-year survival rates were 26.1%, 17.4% and 5.8%, respectively. This clinical result of BNCT in patients with GBM is superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment. - Highlights: ► In this study, we evaluate the clinical outcome of boron neutron capture therapy (BNCT) for malignant brain tumors. ► We have treated 23 glioblastoma (GBM) patients with BNCT without any additional chemotherapy. ► Clinical results of BNCT in patients with GBM are superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment.

  4. Synthesis and in-vivo detection of boronated compounds for use in BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Kabalka, G.W.

    1991-02-01

    The primary objectives of the DOE Program at the University of Tennessee Biomedical Imaging Center are the development of new boron-neutron-capture agents as well as the technology to detect boron compounds in-vivo. The detection technology focuses on the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring BNCT agents in-vivo. A significant portion of the effort is directed toward the design of boron-containing neutron-capture-therapy agents. The UT -- DOE program is unique in that it has access to two state-of-the-art multinuclear magnetic resonance imaging units housed in the Biomedical Imaging Center at the University of Tennessee Medical Center at Knoxville. In addition the UT -- DOE researchers actively collaborate with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory and Oak Ridge Associated Universities). An important goal of the DOE program at UT is to provide training for students (predoctoral and postdoctoral). The University of Tennessee is one of the very few institutions in the world where students have hands-on'' access to both modern scientific equipment and medical imaging modalities such as the clinical MRI units. The academic nature of the program facilitates collaborative interactions with other DOE programs and helps to insure the continued availability of skilled scientists dedicated to the advancement of diagnostic medical procedures. 14 refs., 3 figs.

  5. 'Sequential' Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

    International Nuclear Information System (INIS)

    Molinari, Ana J.; Pozzi, Emiliano C.C.; Hughes, Andrea Monti; Heber, Elisa M.; Garabalino, Marcela A.; Thorp, Silvia I.; Miller, Marcelo; Itoiz, Maria E.; Aromando, Romina F.; Nigg, David W.; Quintana, Jorge; Santa Cruz, Gustavo A.; Trivillin, Veronica A.; Schwint, Amanda E.

    2011-01-01

    In the present study we evaluated the therapeutic effect and/or potential radiotoxicity of the novel 'Tandem' Boron Neutron Capture Therapy (T-BNCT) for the treatment of oral cancer in the hamster cheek pouch model at RA-3 Nuclear Reactor. Two groups of animals were treated with 'Tandem BNCT', i.e. BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (T-24h-BNCT) or 48 h (T-48h-BNCT) later. A total tumor dose-matched single application of BNCT mediated by BPA and GB-10 administered jointly ((BPA + GB-10)-BNCT) was administered to an additional group of animals. At 28 days post-treatment, T-24h-BNCT and T-48h-BNCT induced, respectively, overall tumor control (OTC) of 95% and 91%, with no statistically significant differences between protocols. Tumor response for the single application of (BPA + GB-10)-BNCT was 75%, significantly lower than for T-BNCT. The T-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47% and 60% of the animals respectively. No normal tissue radiotoxicity was associated to tumor control for any of the protocols. 'Tandem' BNCT enhances tumor control in oral cancer and reduces or, at worst, does not increase, mucositis in dose-limiting precancerous tissue.

  6. Research Programs & Initiatives

    Science.gov (United States)

    CGH develops international initiatives and collaborates with other NCI divisions, NCI-designated Cancer Centers, and other countries to support cancer control planning, encourage capacity building, and support cancer research and research networks.

  7. 7. Framework Research Program

    International Nuclear Information System (INIS)

    Donghi, C.; Pieri, Alberto; Manzini, G.

    2006-01-01

    The UE it means to face the problem of the deficiency if investments in the RS field. In particular politics of research are turned to pursue three main goals: the strengthening of the scientific excellence in Europe; the increase of total investments for research; the realization of European space of research [it

  8. Space Technology Research Grants Program

    Data.gov (United States)

    National Aeronautics and Space Administration — The Space Technology Research Grants Program will accelerate the development of "push" technologies to support the future space science and exploration...

  9. Equipment qualification research program: program plan

    International Nuclear Information System (INIS)

    Dong, R.G.; Smith, P.D.

    1982-01-01

    The Lawrence Livermore National Laboratory (LLNL) under the sponsorship of the US Nuclear Regulatory Commission (NRC) has developed this program plan for research in equipment qualification (EQA). In this report the research program which will be executed in accordance with this plan will be referred to as the Equipment Qualification Research Program (EQRP). Covered are electrical and mechanical equipment under the conditions described in the OBJECTIVE section of this report. The EQRP has two phases; Phase I is primarily to produce early results and to develop information for Phase II. Phase I will last 18 months and consists of six projects. The first project is program management. The second project is responsible for in-depth evaluation and review of EQ issues and EQ processes. The third project is responsible for detailed planning to initiate Phase II. The remaining three projects address specific equipment; i.e., valves, electrical equipment, and a pump

  10. An Accelerator Neutron Source for BNCT

    International Nuclear Information System (INIS)

    Blue, Thomas E.

    2006-01-01

    The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were (1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, (2) that the patient treatment time be reasonable, (3) that the proton current required to treat patients in reasonable times be technologically achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally (4) that the treatment be safe for the patients

  11. An Accelerator Neutron Source for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Blue, Thomas, E

    2006-03-14

    The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were 1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, 2) that the patient treatment time be reasonable, 3) that the proton current required to treat patients in reasonable times be technologially achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally 4) that the treatment be safe for the patients.

  12. Ecological Research Division, Marine Research Program

    International Nuclear Information System (INIS)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States

  13. Ecological Research Division, Marine Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States.

  14. Present status of Accelerator-Based BNCT.

    Science.gov (United States)

    Kreiner, Andres Juan; Bergueiro, Javier; Cartelli, Daniel; Baldo, Matias; Castell, Walter; Asoia, Javier Gomez; Padulo, Javier; Suárez Sandín, Juan Carlos; Igarzabal, Marcelo; Erhardt, Julian; Mercuri, Daniel; Valda, Alejandro A; Minsky, Daniel M; Debray, Mario E; Somacal, Hector R; Capoulat, María Eugenia; Herrera, María S; Del Grosso, Mariela F; Gagetti, Leonardo; Anzorena, Manuel Suarez; Canepa, Nicolas; Real, Nicolas; Gun, Marcelo; Tacca, Hernán

    2016-01-01

    This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT). There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines. A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development. Endothermic (7)Li(p,n)(7)Be and (9)Be(p,n)(9)B and exothermic (9)Be(d,n)(10)B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. (9)Be(p,n)(9)B needs at least 4-5 MeV bombarding energy to have a sufficient yield, while (9)Be(d,n)(10)B can be utilized at about 1.4 MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs. (7)Li(p,n)(7)Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. (9)Be(d,n)(10)B at 1.4 MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.

  15. Nuclear wastes: research programs

    International Nuclear Information System (INIS)

    Anon.

    2003-01-01

    The management of long-living and high level radioactive wastes in France belongs to the framework of the December 30, 1991 law which defines three ways of research: the separation and transmutation of radionuclides, their reversible storage or disposal in deep geologic formations, and their processing and surface storage during long duration. Research works are done in partnership between public research and industrial organizations in many French and foreign laboratories. Twelve years after its enforcement, the impact of this law has overstepped the simple research framework and has led to a deep reflection of the society about the use of nuclear energy. This short paper presents the main results obtained so far in the three research ways, the general energy policy of the French government, the industrial progresses made in the framework of the 1991 law and the international context of the management of nuclear wastes. (J.S.)

  16. Biological Defense Research Program

    Science.gov (United States)

    1989-04-01

    Intraperitoneal infectious Dose HEPA High-Efficiency Particle Arresting (filter) HHS US Department of Health and Human Services HID Human Infectious Dose HIV ...as botulinum toxin and snake venom toxins, as well as toxins that affect nerve ion channels. Small animals (rats, mice) and cultured cell lines are...The BDRP has been an ongoing program for a number of years, and, as such, has bee : subject to continuous internal and external review processes to

  17. Human Research Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Strategically, the HRP conducts research and technology development that: 1) enables the development or modification of Agency-level human health and performance...

  18. OPTIMIZATION OF A NEUTRON BEAM SHAPING ASSEMBLY DESIGN FOR BNCT AND ITS DOSIMETRY SIMULATION BASED ON MCNPX

    Directory of Open Access Journals (Sweden)

    I Made Ardana

    2017-10-01

    OPTIMASI DESAIN KOLIMATOR NEUTRON UNTUK SISTEM BNCT DAN UJI DOSIMETRINYA MENGGUNAKAN PROGRAM MCNPX. Telah dilakukan penelitian tentang sistem BNCT yang meliputi dua tahapan simulasi dengan menggunakan program MCNPX yaitu uji simulasi untuk optimasi desain kolimator neutron untuk sistem BNCT berbasis Siklotron 30 MeV dan uji simulasi untuk menghitung fluks neutron dan dosimetri radiasi pada kanker sarkoma jaringan lunak pada leher dan kepala. Tujuan simulasi untuk mendapatkan desain kolimator yang paling optimal dalam memoderasi fluks neutron cepat yang dihasilkan dari sistem target berilium sehingga dapat dihasilkan fluks neutron yang sesuai untuk sistem BNCT. Uji optimasi dilakukan dengan cara memvariasikan bahan dan ketebalan masing-masing komponen dalam kolimator seperi reflektor, moderator, filter neutron cepat, filter neutron thermal, filter radiasi gamma dan lubang keluaran. Desain kolimator yang diperoleh dari hasil optimasi tersusun atas moderator berbahan Al dengan ketebalan 39 cm, filter neutron cepat berbahan LiF2 setebal 8,2 cm, dan filter neutron thermal berbahan B4C setebal 0,5 cm. Untuk reflektor, filter radiasi gamma dan lubang keluaran masing-masing menggunakan bahan PbF2, Pb dan Bi. Fluks neutron epithermal yang dihasilkan dari kolimator yang didesain adalah sebesar 2,83 x 109 n/s cm-2 dan telah memenuhi seluruh parameter fluks neutron yang sesuai untuk sistem BNCT. Selanjutnya uji simulasi dosimetri pada kanker sarkoma jaringan lunak pada leher dan kepala dilakukan dengan cara memvariasikan konsentrasi senyawa boron pada model phantom leher manusia (ORNL. Selanjutnya model phantom tersebut diiradiasi dengan fluks neutron yang berasal dari kolimator yang telah didesain sebelumnya. Hasilnya, fluks neutron thermal mencapai nilai tertinggi pada kedalaman 4,8 cm di dalam model phantom leher ORNL dengan laju dosis tertinggi terletak pada area jaringan kanker. Untuk masing-masing variasi konsentrasi senyawa boron pada model phantom leher ORNL supaya

  19. “Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

    Energy Technology Data Exchange (ETDEWEB)

    Ana J. Molinari; Emiliano C. C. Pozzi; Andrea Monti Hughes; Elisa M. Heber; Marcela A. Garabalino; Silvia I. Thorp; Marcelo Miller; Maria E. Itoiz; Romina F. Aromando; David W. Nigg; Jorge Quintana; Gustavo A. Santa Cruz; Veronica A. Trivillin; Amanda E. Schwint

    2011-04-01

    In the present study we evaluated the therapeutic effect and/or potential radiotoxicity of the novel “Tandem” Boron Neutron Capture Therapy (T-BNCT) for the treatment of oral cancer in the hamster cheek pouch model at RA-3 Nuclear Reactor. Two groups of animals were treated with “Tandem BNCT”, i.e. BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (T-24h-BNCT) or 48 h (T-48h-BNCT) later. A total tumor dose-matched single application of BNCT mediated by BPA and GB-10 administered jointly [(BPA + GB-10)-BNCT] was administered to an additional group of animals. At 28 days post-treatment, T-24h-BNCT and T-48h-BNCT induced, respectively, overall tumor control (OTC) of 95% and 91%, with no statistically significant differences between protocols. Tumor response for the single application of (BPA + GB-10)-BNCT was 75%, significantly lower than for T-BNCT. The T-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47% and 60% of the animals respectively. No normal tissue radiotoxicity was associated to tumor control for any of the protocols. “Tandem” BNCT enhances tumor control in oral cancer and reduces or, at worst, does not increase, mucositis in dose-limiting precancerous tissue.

  20. Tansmutation Research program

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Paul

    2011-07-31

    Six years of research was conducted for the United States Department of Energy, Office of Nuclear Energy between the years of 2006 through 2011 at the University of Nevada, Las Vegas (UNLV). The results of this research are detailed in the narratives for tasks 1-45. The work performed spanned the range of experimental and modeling efforts. Radiochemistry (separations, waste separation, nuclear fuel, remote sensing, and waste forms) , material fabrication, material characterization, corrosion studies, nuclear criticality, sensors, and modeling comprise the major topics of study during these six years.

  1. Radon Research Program, FY-1990

    International Nuclear Information System (INIS)

    1991-03-01

    The Department of Energy (DOE) Office of Health and Environmental Research (OHER) has established a Radon Research Program with the primary objectives of acquiring knowledge necessary to improve estimates of health risks associated with radon exposure and also to improve radon control. Through the Radon Research Program, OHER supports and coordinates the research activities of investigators at facilities all across the nation. From this research, significant advances are being made in our understanding of the health effects of radon. OHER publishes this annual report to provide information to interested researchers and the public about its research activities. This edition of the report summarizes the activities of program researchers during FY90. Chapter 2 of this report describes how risks associated with radon exposure are estimated, what assumptions are made in estimating radon risks for the general public, and how the uncertainties in these assumptions affect the risk estimates. Chapter 3 examines how OHER, through the Radon Research Program, is working to gather information for reducing the uncertainties and improving the risk estimates. Chapter 4 highlights some of the major findings of investigators participating in the Radon Research Program in the past year. And, finally, Chapter 5 discusses the direction in which the program is headed in the future. 20 figs

  2. The hamster cheek pouch (HCP) as an experimental model of oral cancer for BNCT: biodistribution and pharmacokinetics of BPA

    Energy Technology Data Exchange (ETDEWEB)

    Kreimann, E.; Itoiz, M.E.; Dagrosa, A.; Garavaglia, R.; Farias, S.; Batistoni, D.; Schwint, A.E. [National Atomic Energy Commission (Argentina)

    2000-10-01

    We propose and validate the HCP model of oral cancer for BNCT studies. This model serves to explore new applications of the technique, study the biology of BNCT and assess Boron uptake in clinically relevant oral tissues. Tumors are induced by a process that mimics spontaneous malignant transformation instead of by the growth of implanted tumor cells. Syrian hamsters were submitted to tumor induction with a chemical carcinogenesis protocol and then used for biodistribution and pharmacokinetic studies of BPA. The data reveal selective uptake by tumor and, to a lesser degree, by precancerous tissue. Boron concentration in oral tissues and skin was higher than in blood, an issue of clinical relevance given that these tissues may be dose-limiting. Absolute and relative values of Boron concentration would be potentially therapeutic. Boron concentration exhibited a linear relationship with percentage of viable tissue in HCP tumors. The HCP model would provide a novel, contributory approach to BNCT research. (author)

  3. Radon Research Program, FY 1991

    International Nuclear Information System (INIS)

    1992-03-01

    The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny as well as to provide information useful in radon control strategies. Results generated under the Program were highlighted in a National Research Council report on radon dosimetry. The study concluded that the risk of radon exposure is 30% less in homes than in mines. This program summary of book describes the OHER FY-1991 Radon Research Program. It is the fifth in an annual series of program books designed to provide scientific and research information to the public and to other government agencies on the DOE Radon Research Program

  4. Dosimetry and radiobiology at the new RA-3 reactor boron neutron capture therapy (BNCT) facility: Application to the treatment of experimental oral cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pozzi, E. [Research and Production Reactors, National Atomic Energy Commission, Ezeiza Atomic Center (Argentina); Department of Radiobiology, National Atomic Energy Commission, Constituyentes Atomic Center (Argentina)], E-mail: epozzi@cnea.gov.ar; Nigg, D.W. [Idaho National Laboratory, Idaho Falls (United States); Miller, M.; Thorp, S.I. [Instrumentation and Control Department, National Atomic Energy Commission, Ezeiza Atomic Center (Argentina); Heber, E.M. [Department of Radiobiology, National Atomic Energy Commission, Constituyentes Atomic Center (Argentina); Zarza, L.; Estryk, G. [Research and Production Reactors, National Atomic Energy Commission, Ezeiza Atomic Center (Argentina); Monti Hughes, A.; Molinari, A.J.; Garabalino, M. [Department of Radiobiology, National Atomic Energy Commission, Constituyentes Atomic Center (Argentina); Itoiz, M.E. [Department of Radiobiology, National Atomic Energy Commission, Constituyentes Atomic Center (Argentina); Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires (Argentina); Aromando, R.F. [Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires (Argentina); Quintana, J. [Research and Production Reactors, National Atomic Energy Commission, Ezeiza Atomic Center (Argentina); Trivillin, V.A.; Schwint, A.E. [Department of Radiobiology, National Atomic Energy Commission, Constituyentes Atomic Center (Argentina)

    2009-07-15

    The National Atomic Energy Commission of Argentina (CNEA) constructed a novel thermal neutron source for use in boron neutron capture therapy (BNCT) applications at the RA-3 research reactor facility located in Buenos Aires. The aim of the present study was to perform a dosimetric characterization of the facility and undertake radiobiological studies of BNCT in an experimental model of oral cancer in the hamster cheek pouch. The free-field thermal flux was 7.1x10{sup 9} n cm{sup -2} s{sup -1} and the fast neutron flux was 2.5x10{sup 6} n cm{sup -2} s{sup -1}, indicating a very well-thermalized neutron field with negligible fast neutron dose. For radiobiological studies it was necessary to shield the body of the hamster from the neutron flux while exposing the everted cheek pouch bearing the tumors. To that end we developed a lithium (enriched to 95% in {sup 6}Li) carbonate enclosure. Groups of tumor-bearing hamsters were submitted to BPA-BNCT, GB-10-BNCT, (GB-10+BPA)-BNCT or beam only treatments. Normal (non-cancerized) hamsters were treated similarly to evaluate normal tissue radiotoxicity. The total physical dose delivered to tumor with the BNCT treatments ranged from 6 to 8.5 Gy. Tumor control at 30 days ranged from 73% to 85%, with no normal tissue radiotoxicity. Significant but reversible mucositis in precancerous tissue surrounding tumors was associated to BPA-BNCT. The therapeutic success of different BNCT protocols in treating experimental oral cancer at this novel facility was unequivocally demonstrated.

  5. International Research and Studies Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The International Research and Studies Program supports surveys, studies, and instructional materials development to improve and strengthen instruction in modern foreign languages, area studies, and other international fields. The purpose of the program is to improve and strengthen instruction in modern foreign languages, area studies and other…

  6. Prostate Cancer Research Training Program

    Science.gov (United States)

    2017-09-01

    the research program by each mentor will certainly produce important research findings, aided in part by the summer research of...our "translational" research in the form of clinical trials of our adenovirus vaccine in men with prostate cancer. Important in these trials is the ...epidemiology, and treatment. Living in Iowa City for the Summer Housing and Meals - All students will be housed in the one of the residence halls on the

  7. Carborane-containing metalloporphyrins for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Michiko; Joel, D.D.; Nawrocky, M.M.; Micca, P.L. [and others

    1996-12-31

    For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be possible if ratios of {sup 10}B concentrations in tumor to those in normal tissue (e.g. brain and blood) were at least 5: 1. Given that the only current boron carrier being tested clinically in the U.S., p-boronophenyl-alanine[BPA], yields tumor blood and tumor brain ratios of about 3:1, the criteria for new boronated compounds should be to at least match these ratios and maintain tumor boron concentrations greater than 30 {mu}g B/g. Although previously tested boronated porphyrins have not only matched but surpassed these ratios, it was at a cost of greater toxicity. Chemical and hematological assays of blood analytes; showed marked thrombocytopenia, a decrease to about one-tenth the normal concentration of platelets circulating in the blood, in addition to abnormalities in concentrations of circulating enzymes, that indicated liver toxicity. The physical appearance and behavior of the affected mice were different from those of mice injected with solvent only. Although thrombocytopenia and other toxic effects had disappeared after a few days, previously tested porphyrins would not be safe to infuse into patients for BNCT of potentially hemorrhagic malignant tumors in the brain such as glioblastoma multiforme and metastatic melanoma. We synthesized a different boronated porphyrin, tetracarboranylphenylporphyrin, [TCP] and inserted nickel, copper, or manganese into its coordination center. Biological studies of NiTCP in mice and of CuTCP in rats show that these compounds elicit little or no toxicity when given at potentially therapeutic doses.

  8. Clinical practice in BNCT to the brain

    International Nuclear Information System (INIS)

    Nakagawa, Y.

    2001-01-01

    Our concept of Boron Neutron Capture Therapy (BNCT) is to selectively destroy tumour cells using the high LET particles yielded from the 10B(n,α)7Li reactions. The effort of clinical investigators has concentrated on how to escalate the radiation dose at the target point. BNCT in Japan combines thermal neutrons and BSH (Na 2 B 12 H 11 SH). The radiation dose is determined by the neutron fluence at the target point and the boron concentration in the tumour tissue. According to the recent analysis, the ratio of boron concentration (BSH) in tumour tissue and blood is nearly stable at around 1.2 to 1.69. Escalation of the radiation dose was carried out by means of improving the penetration of the thermal neutron beam. Since 1968, 175 patients with glioblastoma (n=83), anaplastic astrocytoma (n=44), low grade astrocytoma (n=16) or other types of tumour (n=32) were treated by BNCT at 5 reactors (HTR n=13, JRR-3 n=1, MulTR n=98, KUR n=30, JRR-2 n=33). The retrospective analysis revealed that the important factors related to the clinical results and QOL of the patients were minimum tumour volume radiation dose, more than 18Gy of physical dose and maximum vascular radiation dose (less than 15Gy) in the normal cortex. We have planned several trials to escalate the target radiation dose. One trial makes use of a cavity in the cortex following debulking surgery of the tumour tissue to improve neutron penetration. The other trial is introduction of epithermal neutron. KUR and JRR-4 were reconstructed and developed to be able to irradiate using epithermal neutrons. The new combination of surgical procedure and irradiation using epithermal neutrons should remarkably improve the target volume dose compared to the radiation dose treated by thermal neutrons. (author)

  9. Carborane-containing metalloporphyrins for BNCT

    International Nuclear Information System (INIS)

    Miura, Michiko; Joel, D.D.; Nawrocky, M.M.; Micca, P.L.

    1996-01-01

    For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be possible if ratios of 10 B concentrations in tumor to those in normal tissue (e.g. brain and blood) were at least 5: 1. Given that the only current boron carrier being tested clinically in the U.S., p-boronophenyl-alanine[BPA], yields tumor blood and tumor brain ratios of about 3:1, the criteria for new boronated compounds should be to at least match these ratios and maintain tumor boron concentrations greater than 30 μg B/g. Although previously tested boronated porphyrins have not only matched but surpassed these ratios, it was at a cost of greater toxicity. Chemical and hematological assays of blood analytes; showed marked thrombocytopenia, a decrease to about one-tenth the normal concentration of platelets circulating in the blood, in addition to abnormalities in concentrations of circulating enzymes, that indicated liver toxicity. The physical appearance and behavior of the affected mice were different from those of mice injected with solvent only. Although thrombocytopenia and other toxic effects had disappeared after a few days, previously tested porphyrins would not be safe to infuse into patients for BNCT of potentially hemorrhagic malignant tumors in the brain such as glioblastoma multiforme and metastatic melanoma. We synthesized a different boronated porphyrin, tetracarboranylphenylporphyrin, [TCP] and inserted nickel, copper, or manganese into its coordination center. Biological studies of NiTCP in mice and of CuTCP in rats show that these compounds elicit little or no toxicity when given at potentially therapeutic doses

  10. Jointly Sponsored Research Program Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2009-03-31

    Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental

  11. Water Environment Research Foundation research program

    Science.gov (United States)

    Noss, Charles I.

    2002-02-01

    The Water Environment Research Foundation (WERF) is a not- for-profit organization established in 1989 to advance the science and technology of a broad spectrum of environmental and human health concerns to the wastewater industry and the public. It is a unique public/private partnership between utilities, academia, government, and industry, committed to funding research by leveraging resources and expertise to develop and disseminate sound scientific and technological information. Funded by subscribers, grants and contributions, WERF manages a broad array of research projects aimed at protecting human health and the environment. While WERF funds and manages projects, the actual research is carried out by individual organizations or teams composed of utilities, consultants, universities, and industrial or commercial firms. Examples of WERF's current research program include the investigation of on- line monitoring techniques for microbial and chemical contaminants in water and wastewater, optimization of processes for pathogen removal and inactivation, improved treatment of toxic compounds, and assessing the potential risks to public health from exposure to these microbial and chemical contaminants. This paper will provide an overview of the program, research funded to date, and technology needs for the future.

  12. Fusion program research materials inventory

    International Nuclear Information System (INIS)

    Roche, T.K.; Wiffen, F.W.; Davis, J.W.; Lechtenberg, T.A.

    1984-01-01

    Oak Ridge National Laboratory maintains a central inventory of research materials to provide a common supply of materials for the Fusion Reactor Materials Program. This will minimize unintended material variations and provide for economy in procurement and for centralized record keeping. Initially this inventory is to focus on materials related to first-wall and structural applications and related research, but various special purpose materials may be added in the future. The use of materials from this inventory for research that is coordinated with or otherwise related technically to the Fusion Reactor Materials Program of DOE is encouraged

  13. Program of Research in Aeronautics

    Science.gov (United States)

    1981-01-01

    A prospectus of the educational and research opportunities available at the Joint Institute for Advancement of Flight Sciences, operated at NASA Langley Research Center in conjunction with George Washington University's School of Engineering and Applied Sciences is presented. Requirements of admission to various degree programs are given as well as the course offerings in the areas of acoustics, aeronautics, environmental modelling, materials science, and structures and dynamics. Research facilities for each field of study are described. Presentations and publications (including dissertations and theses) generated by each program are listed as well as faculty members visting scientists and engineers.

  14. NASA's computer science research program

    Science.gov (United States)

    Larsen, R. L.

    1983-01-01

    Following a major assessment of NASA's computing technology needs, a new program of computer science research has been initiated by the Agency. The program includes work in concurrent processing, management of large scale scientific databases, software engineering, reliable computing, and artificial intelligence. The program is driven by applications requirements in computational fluid dynamics, image processing, sensor data management, real-time mission control and autonomous systems. It consists of university research, in-house NASA research, and NASA's Research Institute for Advanced Computer Science (RIACS) and Institute for Computer Applications in Science and Engineering (ICASE). The overall goal is to provide the technical foundation within NASA to exploit advancing computing technology in aerospace applications.

  15. Synthesis and in-vivo detection of boronated compounds for use in BNCT. Comprehensive progress report, August 1, 1989--July 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Kabalka, G.W.

    1992-01-01

    The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The UT-DOE program is unique in that it has access to both state-of-the-art whole-body and microscopy MRI instruments.

  16. Research program plan: steam generators

    International Nuclear Information System (INIS)

    Muscara, J.; Serpan, C.Z. Jr.

    1985-07-01

    This document presents a plan for research in Steam Generators to be performed by the Materials Engineering Branch, MEBR, Division of Engineering Technology, (EDET), Office of Nuclear Regulatory Research. It is one of four plans describing the ongoing research in the corresponding areas of MEBR activity. In order to answer the questions posed, the Steam Generator Program has been organized with the three elements of non-destructive examination; mechanical integrity testing; and corrosion, cleaning and decontamination

  17. The life-extension and upgrade program of the Tsing Hua Open-pool Reactor (THOR) and its research prospectives

    International Nuclear Information System (INIS)

    Kai, J.-J.

    1992-01-01

    The Tsing Hua Open-Pool Reactor (THOR) has been operated for thirty years. It is the regulations of the ROCAEC that any reactor shall be decommissioned after forty-year operation since the first fuel loading. Therefore, for extending the lifetime of THOR, it is necessary to have a life-extension program to be approved by the ROCAEC and also completed by the year of 1997. At the same time, for proceeding new research purposes, it is planed to upgrade the thermal power of THOR from 1 Wth up to 3 Wth and hopefully to reach the maximum thermal neutron flux of 5x10 13 n/cm 2 .s and the fast flux close to that order. New research directions involve (a) boron-captured neutron cancer therapy (BNCT) (b) small-angle neutron scattering (SANS). (author)

  18. The BNCT project in the Czech Republic

    International Nuclear Information System (INIS)

    Burian, J.; Marek, M.; Rataj, J.; Honova, H.; Petruzelka, L.; Prokes, K.; Tovarys, F.; Dbaly, V.; Honzatko, J.; Tomandl, I.

    2000-01-01

    The start of clinical trials is expected before NCT Osaka 2000. The experiences from different part of project are presented. The BNCT facility at LVR-15 reactor of NRI consists of epithermal neutron beam with improved construction (6.98 x 10 8 /cm 2 s with acceptable background of fast neutrons and gammas) and irradiation and control rooms equipped by appropriate devices. Internationally-recognized software MacNCTPLAN is utilized for computational dosimetry and treatment planning. In the part of protocol the following parameters have been assessed: patient selection, BSH dosage, fractionation, starting dose, dose escalation steps. At the LVR-15, at horizontal channel, a prompt gamma ray analysis (PGRA) system has been developed and is operated for BNCT purposes. Some human blood samples were analyzed and compared with classical ICP method. During the process of licensing the experience was obtained, some notes are discussed in the paper. The first results were received for the study of biological effect of the LVR source for small animal model. (author)

  19. Treatment optimization of a brain tumor in BNCT by Monte Carlo method

    International Nuclear Information System (INIS)

    Nejat, S.; Binesh, A.; Karimian, A.

    2012-01-01

    Brain cancers are one of the most important diseases. BNCT (Boron Neutron Capture Therapy) is used to brain tumor treatment. In this method the 1 0B (n,α) 7 Li reaction is used. The purpose of this study is absorbed dose evaluation of tumoral and healthy parts of brain. To achieve this aim the brain was simulated by a cylindrical phantom with the dimensions of 20 cm in diameter and height. In BNCT treatment the BSH (Na 2 B 12 H 11 SH) is injected to the human body and absorbed in the healthy and tumoral parts by the ratios of 18 and 65 ppm respectively. So in this research the absorption of BSH in tumoral and healthy parts of brain was considered as the mentioned ratio. Then the neutron with the energy range of 50 eV - 10 keV was exposed to the brain and maximum absorbed dose in healthy and tumoral parts of brain were calculated for a cylindrical tumor with the thickness of about 1 cm which was considered in 5.5 cm depth of brain. This research showed the suitable energy to treat this tumor by BNCT is interval 4 keV- 6keV. The average of dose which is met with healthy and tumor tissue was gained for 6 keV energy of brain 1.18x10 -12 cGy/n and 5.98x10 -12 cGy/n respectively. Maximum of dose which is met with healthy tissue was 4.3 Gy which is much less than standard amount 12.6 Gy. Therefore BNCT method is known as an effective way in the therapy of this kind of tumor. (authors)

  20. Containment integrity research program plan

    International Nuclear Information System (INIS)

    1987-08-01

    This report presents a plan for research on the question of containment performance in postulated severe accident scenarios. It focuses on the research being performed by the Structural and Seismic Engineering Branch, Division of Engineering, Office of Nuclear Regulatory Research. Summaries of the plans for this work have previously been published in the ''Nuclear Power Plant Severe Accident Research Plan'' (NUREG-0900). This report provides an update to reflect current status. This plan provides a summary of results to date as well as an outline of planned activities and milestones to the contemplated completion of the program in FY 1989

  1. FiR 1 reactor in service for boron neutron capture therapy (BNCT) and isotope production

    International Nuclear Information System (INIS)

    Auterinen, I.; Salmenhaara, S.E.J. . Author

    2004-01-01

    The FiR 1 reactor, a 250 kW Triga reactor, has been in operation since 1962. The main purpose for the existence of the reactor is now the Boron Neutron Capture Therapy (BNCT), but FiR 1 has also an important national role in providing local enterprises and research institutions in the fields of industrial measurements, pharmaceuticals, electronics etc. with isotope production and activation analysis services. In the 1990's a BNCT treatment facility was built at the FiR 1 reactor located at Technical Research Centre of Finland. A special new neutron moderator material Fluental TM (Al+AlF3+Li) developed at VTT ensures the superior quality of the neutron beam. Also the treatment environment is of world top quality after a major renovation of the whole reactor building in 1997. Recently the lithiated polyethylene neutron shielding of the beam aperture was modified to ease the positioning of the patient close to the beam aperture. Increasing the reactor power to 500 kW would allow positioning of the patient further away from the beam aperture. Possibilities to accomplish a safety analysis for this is currently under considerations. Over thirty patients have been treated at FiR 1 since May 1999, when the license for patient treatment was granted to the responsible BNCT treatment organization, Boneca Corporation. Currently three clinical trial protocols for tumours in the brain as well as in the head and neck region are recruiting patients. (author)

  2. Some recent developments in treatment planning software and methodology for BNCT

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wheeler, F.J.; Wessol, D.E.; Wemple, C.A.; Babcock, R.; Capala, J.

    1996-01-01

    Over the past several years/the Idaho National Engineering Laboratory (INEL) has led the development of a unique, internationally-recognized set of software modules (BNCT rtpe) for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT). The computational capability represented by this software is essential to the proper administration of all forms of radiotherapy for cancer. Such software addresses the need to perform pretreatment computation and optimization of the radiation dose distribution in the target volume. This permits the achievement of the optimal therapeutic ratio (tumor dose relative to critical normal tissue dose) for each individual patient via a systematic procedure for specifying the appropriate irradiation parameters to be employed for a given treatment. These parameters include angle of therapy beam incidence, beam aperture and shape,and beam intensity as a function of position across the beam front. The INEL software is used for treatment planning in the current series of human glioma trials at Brookhaven National Laboratory (BNL) and has also been licensed for research and developmental purposes to several other BNCT research centers in the US and in Europe

  3. Some recent developments in treatment planning software and methodology for BNCT

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wheeler, F.J.; Wessol, D.E.

    1996-01-01

    Over the past several years the Idaho National Engineering Laboratory (INEL) has led the development of a unique, internationally-recognized set of software modules (BNCT-rtpe) for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT). The computational capability represented by this software is essential to the proper administration of all forms of radiotherapy for cancer. Such software addresses the need to perform pretreatment computation and optimization of the radiation dose distribution in the target volume. This permits the achievement of the optimal therapeutic ratio (tumor dose relative to critical normal tissue dose) for each individual patient via a systematic procedure for specifying the appropriate irradiation parameters to be employed for a given treatment. These parameters include angle of therapy beam incidence, beam aperture and shape, and beam intensity as a function of position across the beam front. The INEL software is used for treatment planning in the current series of human glioma trials at Brookhaven National Laboratory (BNL) and has also been licensed for research and developmental purposes to several other BNCT research centers in the US and in Europe

  4. Prostate Cancer Research Training Program

    Science.gov (United States)

    2012-05-01

    brief description of research in the la boratories of each University of Iowa mentor. At this point in time the program is 8 weeks long...www.uihealthcare.com/depts/med/urology/urolo gymds/luo.html A major research project in our la boratory is to develop a novel therapeutic...wright.shtml?menu =1&tab=facultyTab The Wright Labo ratory is focuse d on defining the composition, activity, and overall cellul ar function of

  5. Dosimetric study of varying aperture-surface distance at the Finnish BNCT facility

    International Nuclear Information System (INIS)

    Uusi-Simola, Jouni; Seppaelae, Tiina; Nieminen, Katja; Kotiluoto, Petri; Seren, Tom; Auterinen, Iiro; Kortesniemi, Mika; Savolainen, Sauli

    2006-01-01

    Comparison of experimental and calculated dosimetric values in a water phantom was performed at the Finnish BNCT facility at the FiR 1 research reactor. The purpose was to study the effect of changing aperture to surface distance (ASD) to radiation dose and to verify the accuracy of the treatment planning and to provide data for comparison of the methods. A magnesium ionisation chamber flushed with argon gas was used to measure absorbed photon dose rate. Diluted manganese (Mn) and gold (Au) foils and Mn wires were used to determine Mn and Au activation reaction rates. Computer simulations with both SERA and MCNP programs were used to independently calculate the corresponding values. Photon dose and activation reaction rate depth profiles at beam central axis an axial profiles at 2.5 and 6 cm depths were measured and calculated for 11 and 14 and 17 cm diameter apertures. Depth profiles for activation reaction rates were determined for the clinically used 11 and 14 cm diameter apertures for 0, 5, and 10 cm ASD. In addition, the optional 17 cm beam was characterised at 0 and 5 cm ASD. The beam intensity decreases by approximately 20% and 40% when ASD is increased to 5 cm or 10 cm, respectively. The shape of the 55 Mn activation reaction rate depth profile and photon depth radial profile did not vary more than 5% for the 14 cm beam when the ASD was increased from 0 cm to 10 cm. (author)

  6. The Australian synchrotron research program

    International Nuclear Information System (INIS)

    Garrett, R.F.

    1998-01-01

    Full text: The Australian Synchrotron Research Program (ASRP) was established in 1996 under a 5 year grant from the Australian Government, and is managed by ANSTO on behalf of a consortium of Australian universities and research organisations. It has taken over the operation of the Australian National Beamline Facility (ANBF) at the Photon Factory, and has joined two CATS at the Advanced Photon Source: the Synchrotron Radiation Instrumentation CAT (SRI-CAT) and the Consortium for Advanced Radiation Sources (CARS). The ASRP thus manages a comprehensive range of synchrotron radiation research facilities for Australian science. The ANBF is a general purpose hard X-ray beamline which has been in operation at the Photon Factory since 1993. It currently caters for about 35 Australian research teams per year. The facilities available at the ANBF will be presented and the research program will be summarised. The ASRP facilities at the APS comprise the 5 sectors operated by SRI-CAT, BioCARS and ChemMatCARS. A brief description will be given of the ASRP research programs at the APS, which will considerably broaden the scope of Australian synchrotron science

  7. Optimization of beam shaping assembly based on D-T neutron generator and dose evaluation for BNCT

    Science.gov (United States)

    Naeem, Hamza; Chen, Chaobin; Zheng, Huaqing; Song, Jing

    2017-04-01

    The feasibility of developing an epithermal neutron beam for a boron neutron capture therapy (BNCT) facility based on a high intensity D-T fusion neutron generator (HINEG) and using the Monte Carlo code SuperMC (Super Monte Carlo simulation program for nuclear and radiation process) is proposed in this study. The Monte Carlo code SuperMC is used to determine and optimize the final configuration of the beam shaping assembly (BSA). The optimal BSA design in a cylindrical geometry which consists of a natural uranium sphere (14 cm) as a neutron multiplier, AlF3 and TiF3 as moderators (20 cm each), Cd (1 mm) as a thermal neutron filter, Bi (5 cm) as a gamma shield, and Pb as a reflector and collimator to guide neutrons towards the exit window. The epithermal neutron beam flux of the proposed model is 5.73 × 109 n/cm2s, and other dosimetric parameters for the BNCT reported by IAEA-TECDOC-1223 have been verified. The phantom dose analysis shows that the designed BSA is accurate, efficient and suitable for BNCT applications. Thus, the Monte Carlo code SuperMC is concluded to be capable of simulating the BSA and the dose calculation for BNCT, and high epithermal flux can be achieved using proposed BSA.

  8. Breakthrough Propulsion Physics Research Program

    Science.gov (United States)

    Millis, Marc G.

    1996-01-01

    In 1996, a team of government, university and industry researchers proposed a program to seek the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, propulsion that can approach and, if possible, circumvent light speed, and breakthrough methods of energy production to power such devices. This Breakthrough Propulsion Physics program, managed by Lewis Research Center, is one part of a comprehensive, long range Advanced Space Transportation Plan managed by Marshall Space Flight Center. Because the breakthrough goals are beyond existing science, a main emphasis of this program is to establish metrics and ground rules to produce near-term credible progress toward these incredible possibilities. An introduction to the emerging scientific possibilities from which such solutions can be sought is also presented.

  9. Optimiturve research program in 1991

    International Nuclear Information System (INIS)

    Leinonen, A.

    1992-01-01

    The target of the program is to develop a peat production method, based on solar energy, by which it is possible to double the present annual hectare yield. It has been estimated that if the target of the program can be fulfilled it is possible to decrease the production costs by about 20 %. The target has been strived by intensification of utilization of solar radiation, by improving the collection rate of dry peat, by decreasing the rain effects on production, by lengthening the production season and by decreasing the storage losses. Three new peat production methods have so far been developed in the Optimiturve research program, by which it is possible to obtain the targets of the program. These methods are the new sod peat production method, the ridge drying method and the Multi method

  10. Retrospective review of the clinical BNCT trial at Brookhaven National Laboratory

    International Nuclear Information System (INIS)

    Diaz, A.Z.; Chanana, A.D.; Coderre, J.A.; Ma, R.

    2000-01-01

    The primary objective of the phase I/II dose escalation studies was to evaluate the safety of the boronophenylalanine-fructose (BPA-F) mediated boron neutron capture therapy (BNCT) in subjects with glioblastoma multiforme (GBM). A secondary objective was to retrospectively assess the palliation of GBM by BNCT. Fifty-three subjects with GBM were treated under multiple dose escalation protocols at the Brookhaven Medical Research Reactor (BMRR). Twenty-six subjects were treated using one field, 17 subjects were treated using 2 fields and 10 subjects were treated using 3 fields. BPA-F related toxicity was not observed. The maximum radiation dose to a volume of approximately 1 cc of the normal brain varied from 8.9 to 15.9 gray-equivalent (Gy-Eq). The volume-weighted average radiation dose to normal brain varied from 1.9 to 9.5 Gy-Eq. Six RTOG (Radiation Therapy Oncology Group) grade 3 or 4 toxicities were attributed to BNCT. Four of the 53 subjects are still alive with 3 of them free of recurrent disease with over two years follow-up. The median times to progression and median survival time from diagnosis were 28.4 weeks and 12.8 months respectively. (author)

  11. Quality assurance for BNCT at nuclear facilities. A necessary burden or the unavoidable seal of approval

    International Nuclear Information System (INIS)

    Moss, R.; Morrissey, J.; Sauerwein, W.; Hideghety, K.; Rassow, J.; Stecher-Rasmussen, F.

    2000-01-01

    The BNCT clinical trial at the HFR Petten is performed on a completely multi-national basis. The irradiation facility is located in one country (The Netherlands), is operated by an international team of experts under the leadership of a radiotherapist from another country (Germany) and treats patients coming from different European countries. In gaining the necessary approval, it became apparent, especially in the many discussions with the (Dutch) Health authorities that Quality Assurance (QA) would be and is a critical aspect. This is even more so, in the case of BNCT, where it was not only a (relatively) new experimental treatment (in 1996/97) about to be performed for the first time in Europe, but it was to be performed in a non-hospital environment and furthermore in a nuclear research reactor. It was necessary therefore to comply, as closely as possible, with similarly accepted practices in conventional radiotherapy. Despite QA being a sometimes burdensome task, this paper nevertheless raises the issue as to whether it is necessary or whether it is the seal of approval for BNCT as an acceptable mode of treatment in mainstream radiotherapy. (author)

  12. An accelerator neutron source for BNCT. Technical progress report, 1 June 1993--31 May 1994

    International Nuclear Information System (INIS)

    Blue, T.E.; Vafai, K.

    1994-02-01

    This is the progress report for the project entitled, ''An Accelerator Neutron Source for BNCT.'' The progress report is for the period from July 1, 1993 to date. The overall objective of our research project is to develop an Accelerator Epithermal Neutron Irradiation Facility (AENIF) for Boron Neutron Capture Therapy (BNCT). The AENIF consists of a 2.5 MeV high current proton accelerator, a lithium target to produce source neutrons, and a moderator/reflector assembly to obtain from the energetic source neutrons an epithermal neutron field suitable for BNCT treatments. Our project goals are to develop the non-accelerator components of the AENIF, and to specifically include in our development: (1) design, numerical simulation, and experimental verification of a target assembly which is capable of removing 75 kW of beam power; (2) re-optimization of the moderator assembly design based on in-phantom dose assessments using neutron spectra calculated in phantom and an energy-dependent neutron Relative Biological Effectiveness (RBE); (3) construction of a prototype moderator assembly and confirmation of its design by measurements; (4) design of the shielding of the accelerator and treatment rooms for an AENIF; and (5) design of a high energy beam transport system which is compatible with the shielding design and the thermal-hydraulic design

  13. Subsurface transport program: Research summary

    International Nuclear Information System (INIS)

    1987-01-01

    DOE's research program in subsurface transport is designed to provide a base of fundamental scientific information so that the geochemical, hydrological, and biological mechanisms that contribute to the transport and long term fate of energy related contaminants in subsurface ecosystems can be understood. Understanding the physical and chemical mechanisms that control the transport of single and co-contaminants is the underlying concern of the program. Particular attention is given to interdisciplinary research and to geosphere-biosphere interactions. The scientific results of the program will contribute to resolving Departmental questions related to the disposal of energy-producing and defense wastes. The background papers prepared in support of this document contain additional information on the relevance of the research in the long term to energy-producing technologies. Detailed scientific plans and other research documents are available for high priority research areas, for example, in subsurface transport of organic chemicals and mixtures and in the microbiology of deep aquifers. 5 figs., 1 tab

  14. A case of astrocytoma, 19 year history after BNCT

    International Nuclear Information System (INIS)

    Kamano, Shuji

    2006-01-01

    A 39-year-old man had received Boron Neutron Capture Therapy (BNCT) in 1987 for a Grade II Astrocytoma. He gradually exacerbated and received a second operation in 1994. The mass taken in the second operation is almost competent with radiation necrosis. Following that, he shows no signs of recurrence. Currently, he has returned to full time employment in physical labor. This case suggests effectiveness of BNCT for rather low-grade astrocytomas. (author)

  15. Clean Coal Program Research Activities

    Energy Technology Data Exchange (ETDEWEB)

    Larry Baxter; Eric Eddings; Thomas Fletcher; Kerry Kelly; JoAnn Lighty; Ronald Pugmire; Adel Sarofim; Geoffrey Silcox; Phillip Smith; Jeremy Thornock; Jost Wendt; Kevin Whitty

    2009-03-31

    Although remarkable progress has been made in developing technologies for the clean and efficient utilization of coal, the biggest challenge in the utilization of coal is still the protection of the environment. Specifically, electric utilities face increasingly stringent restriction on the emissions of NO{sub x} and SO{sub x}, new mercury emission standards, and mounting pressure for the mitigation of CO{sub 2} emissions, an environmental challenge that is greater than any they have previously faced. The Utah Clean Coal Program addressed issues related to innovations for existing power plants including retrofit technologies for carbon capture and sequestration (CCS) or green field plants with CCS. The Program focused on the following areas: simulation, mercury control, oxycoal combustion, gasification, sequestration, chemical looping combustion, materials investigations and student research experiences. The goal of this program was to begin to integrate the experimental and simulation activities and to partner with NETL researchers to integrate the Program's results with those at NETL, using simulation as the vehicle for integration and innovation. The investigators also committed to training students in coal utilization technology tuned to the environmental constraints that we face in the future; to this end the Program supported approximately 12 graduate students toward the completion of their graduate degree in addition to numerous undergraduate students. With the increased importance of coal for energy independence, training of graduate and undergraduate students in the development of new technologies is critical.

  16. Radon Research Program, FY 1992

    International Nuclear Information System (INIS)

    1993-04-01

    The United States Department of Energy, Office of Health and Environmental Research (DOE/OHER) is the principal federal agency conducting basic research related to indoor radon. The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. There still remains a significant number of uncertainties in the currently available knowledge that is used to estimate lung cancer risk from exposure to environmental levels of radon and its progeny. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny and to identify and understand biological mechanisms of lung cancer development and required copollutants at low levels of exposure. Information useful in radon control strategies is also provided by the basic science undertaken in this program

  17. CELSS research and development program

    Science.gov (United States)

    Bubenheim, David

    1990-01-01

    Research in Controlled Ecological Life Support Systems (CELSS) conducted by NASA indicate that plant based systems are feasible candidates for human support in space. Ames has responsibility for research and development, systems integration and control, and space flight experiment portions of the CELSS program. Important areas for development of new methods and technologies are biomass production, waste processing, water purification, air revitalization, and food processing. For the plant system, the approach was to identify the flexibility and response time for the food, water, and oxygen production, and carbon dioxide consumption processes. Tremendous increases in productivity, compared with terrestrial agriculture, were realized. Waste processing research emphasizes recycle (transformation) of human wastes, trash, and inedible biomass to forms usable as inputs to the plant production system. Efforts to improve efficiency of the plant system, select new CELSS crops for a balanced diet, and initiate closed system research with the Crop Growth Research Chambers continue. The System Control and Integration program goal is to insure orchestrated system operation of the biological, physical, and chemical operation of the biological, physical, and chemical component processors of the CELSS. Space flight studies are planned to verify adequate operation of the system in reduced gravity or microgravity environments.

  18. Nuclear plant aging research program

    International Nuclear Information System (INIS)

    Eissenberg, D.M.

    1987-01-01

    The U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research, has established the Nuclear Plant Aging Research (NPAR) program in its Division of Engineering Technology. Principal contractors for this program include Oak Ridge National Laboratory, Brookhaven National Laboratory, Idaho National Engineering Laboratory, and Pacific Northwest Laboratory. The program goals are: to identify and characterize time-dependent degradation (aging) of nuclear plant safety-related electrical and mechanical components which could lead to loss of safety function; to identify and recommend methods for detecting and trending aging effects prior to loss of safety function so that timely maintenance can be implemented; and to recommend maintenance practices for mitigating the effects of aging. Research activities include prioritization of system and component aging in nuclear plants, characterization of aging degradation of specific components including identification of functional indicators useful for trending degradation, and testing of practical methods and devices for measuring the functional indicators. Aging assessments have been completed on electric motors, snubbers, motor-operated valves, and check valves. Testing of trending methods and devices for motor-operated valves and check valves is in progress

  19. Comparison and analysis of BNCT radiation dose between gold wire and JCDS measurement

    International Nuclear Information System (INIS)

    Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, Hiroaki

    2006-01-01

    We compared and evaluated boron neutron capture therapy (BNCT) radiation dose between gold wire measurement and JAERI Computational Dosimetry System (JCDS). Gold wire analysis demonstrates the actual BNCT dose though it dose not reflect the real the maximum and minimum dose in tumor tissue. We can conclude that JCDS is precise and high-reliable dose planning system for BNCT. (author)

  20. Protocols for BNCT of glioblastoma multiforme at Brookhaven: Practical considerations

    Energy Technology Data Exchange (ETDEWEB)

    Chanana, A.D.; Coderre, J.A.; Joel, D.D.; Slatkin, D.N.

    1996-12-31

    In this report we discuss some issues considered in selecting initial protocols for boron neutron capture therapy (BNCT) of human glioblastoma multiforme. First the tolerance of normal tissues, especially the brain, to the radiation field. Radiation doses limits were based on results with human and animal exposures. Estimates of tumor control doses were based on the results of single-fraction photon therapy and single fraction BNCT both in humans and experimental animals. Of the two boron compounds (BSH and BPA), BPA was chosen since a FDA-sanctioned protocol for distribution in humans was in effect at the time the first BNCT protocols were written and therapy studies in experimental animals had shown it to be more effective than BSH.

  1. IRT-Sofia BNCT beam tube optimization study.

    Science.gov (United States)

    Belousov, S; Mitev, M; Ilieva, K; Riley, K; Harling, O

    2011-12-01

    An optimization study of IRT-Sofia BNCT beam tube is presented. In the study we used the MIT/FCB experience. The enlarging of filter/moderator cross section dimensions and the decreasing of collimator length within the limits of the IRT-Sofia reactor design were analyzed. The influence of beam and reactor core axes non-coincidence on the beam properties was also evaluated. The irradiation resistance of polytetrafluoroethylene (Teflon(®)) was also evaluated. The results provide information for making decisions on the IRT-Sofia BNCT beam construction. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Dosimetric analysis of BNCT - Boron Neutron Capture Therapy - coupled to 252Cf brachytherapy

    International Nuclear Information System (INIS)

    Brandao, Samia F.; Campos, Tarcisio P.R.

    2009-01-01

    The incidence of brain tumors is increasing in world population; however, the treatments employed in this type of tumor have a high rate of failure and in some cases have been considered palliative, depending on histology and staging of tumor. Its necessary to achieve the control tumor dose without the spread irradiation cause damage in the brain, affecting patient neurological function. Stereotactic radiosurgery is a technique that achieves this; nevertheless, other techniques that can be used on the brain tumor control must be developed, in order to guarantee lower dose on health surroundings tissues other techniques must be developing. The 252 Cf brachytherapy applied to brain tumors has already been suggested, showing promising results in comparison to photon source, since the active source is placed into the tumor, providing greater dose deposition, while more distant regions are spared. BNCT - Boron Neutron Capture Therapy - is another technique that is in developing to brain tumors control, showing theoretical superiority on the rules of conventional treatments, due to a selective irradiation of neoplasics cells, after the patient receives a borate compound infusion and be subjected to a epithermal neutrons beam. This work presents dosimetric studies of the coupling techniques: BNCT with 252 Cf brachytherapy, conducted through computer simulation in MCNP5 code, using a precise and well discretized voxel model of human head, which was incorporated a representative Glioblastoma Multiform tumor. The dosimetric results from MCNP5 code were exported to SISCODES program, which generated isodose curves representing absorbed dose rate in the brain. Isodose curves, neutron fluency, and dose components from BNCT and 252 Cf brachytherapy are presented in this paper. (author)

  3. Calculational evaluations of the proposal for a reference dosimetric phantom for BNCT

    International Nuclear Information System (INIS)

    Bjugg, H.; Seppaelae, T.; Auterinen, I.; Kotiluoto, P.; Savolainen, S.

    2001-01-01

    Standard dosimetric phantoms are used in radiotherapy to compare irradiations under standard conditions. They provide volumes of tissue substitute for the measurement of absorbed dose and are large enough to ensure that full contribution to the absorbed dose from scattered radiation is received at the point of measurement. Aim of this study was to find out a recommendation for the boundary values of size of a reference phantom. These reference conditions for the reference measurement methods are created for 'A code of practise for dosimetry, of BNCT in Europe' project. The major objective of the project is to prepare detailed guidelines for the dosimetry of epithermal neutron beams to be used for treatment of cancer patients by Boron Neutron Capture Therapy (BNCT) at European research reactors and accelerators. For this objective Monte Carlo simulations have been carried out with MCNP 4B code in three different cubic phantoms for studying effect of different phantom sizes in important radiation components. These three phantoms are the proposed reference (measurement) phantom (20*20*20 cm), a phantom that was assumed to model an infinite phantom, and a smaller (15*15*15 cm) cubic phantom which exists in Petten BNCT facility in Netherlands. Function of the smallest phantom was to study acceptable lower limit to the phantom size to still reach the reference conditions. All the simulated phantoms were cubic water phantoms with one 0.5 cm thick (beam side) wall and three 1 cm thick walls of PMMA (polymethyl-methacrylate). The comparisons were done with calculations of the thermal, epithermal and fast neutron fluence rates in analogous points. The source specification of the MCNP runs were accordance of 250 kW FiR 1 research reactor neutron beam with 14 cm beam aperture. In order to minimise the statistical error of the Monte Carlo calculations, over 60*106 source particles were simulated for infinite and reference phantom cases. Calculation results were in good

  4. Boron Neutron Capture Therapty (BNCT) in an Oral Precancer Model: Therapeutic Benefits and Potential Toxicity of a Double Application of BNCT with a Six-Week Interval

    Energy Technology Data Exchange (ETDEWEB)

    Andrea Monti Hughes; Emiliano C.C. Pozzi; Elisa M. Heber; Silvia Thorp; Marcelo Miller; Maria E. Itoiz; Romina F. Aromando; Ana J. Molinari; Marcela A. Garabalino; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2011-11-01

    Given the clinical relevance of locoregional recurrences in head and neck cancer, we developed a novel experimental model of premalignant tissue in the hamster cheek pouch for long-term studies and demonstrated the partial inhibitory effect of a single application of Boron Neutron Capture Therapy (BNCT) on tumor development from premalignant tissue. The aim of the present study was to evaluate the effect of a double application of BNCT with a 6 week interval in terms of inhibitory effect on tumor development, toxicity and DNA synthesis. We performed a double application, 6 weeks apart, of (1) BNCT mediated by boronophenylalanine (BPA-BNCT); (2) BNCT mediated by the combined application of decahydrodecaborate (GB-10) and BPA [(GB-10 + BPA)-BNCT] or (3) beam-only, at RA-3 nuclear reactor and followed the animals for 8 months. The control group was cancerized and sham-irradiated. BPA-BNCT, (GB- 10 + BPA)-BNCT and beam-only induced a reduction in tumor development from premalignant tissue that persisted until 8, 3, and 2 months respectively. An early maximum inhibition of 100% was observed for all 3 protocols. No normal tissue radiotoxicity was detected. Reversible mucositis was observed in premalignant tissue, peaking at 1 week and resolving by the third week after each irradiation. Mucositis after the second application was not exacerbated by the first application. DNA synthesis was significantly reduced in premalignant tissue 8 months post-BNCT. A double application of BPA-BNCT and (GB-10 + BPA)-BNCT, 6 weeks apart, could be used therapeutically at no additional cost in terms of radiotoxicity in normal and dose-limiting tissues.

  5. Neutron Flux Measurement Produced by BNCT Target using Proton Beam

    International Nuclear Information System (INIS)

    Ha, Jang Ho; Kim, Yong Kyun; Chai, Jong Seo; Kim, Jong Kyung

    2005-01-01

    We are investigating neutron production target system performance for boron captured neutron therapy (BNCT). The epithermal neutron is useful for this therapy and in present study we performed a simple method to measure neutron flux and energy, which are important for the accurate cancer therapy. The simple method and result of neutron flux and energy measurement experiment are presented

  6. Joint Assessment of ETRR-2 Research Reactor Operations Program, Capabilities, and Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bissani, M; O' Kelly, D S

    2006-05-08

    A joint assessment meeting was conducted at the Egyptian Atomic Energy Agency (EAEA) followed by a tour of Egyptian Second Research Reactor (ETRR-2) on March 22 and 23, 2006. The purpose of the visit was to evaluate the capabilities of the new research reactor and its operations under Action Sheet 4 between the U.S. DOE and the EAEA, ''Research Reactor Operation'', and Action Sheet 6, ''Technical assistance in The Production of Radioisotopes''. Preliminary Recommendations of the joint assessment are as follows: (1) ETRR-2 utilization should be increased by encouraging frequent and sustained operations. This can be accomplished in part by (a) Improving the supply-chain management for fresh reactor fuel and alleviating the perception that the existing fuel inventory should be conserved due to unreliable fuel supply; and (b) Promulgating a policy for sample irradiation priority that encourages the use of the reactor and does not leave the decision of when to operate entirely at the discretion of reactor operations staff. (2) Each experimental facility in operation or built for a single purpose should be reevaluated to focus on those that most meet the goals of the EAEA strategic business plan. Temporary or long-term elimination of some experimental programs might be necessary to provide more focused utilization. There may be instances of emerging reactor applications for which no experimental facility is yet designed or envisioned. In some cases, an experimental facility may have a more beneficial use than the purpose for which it was originally designed. For example, (a) An effective Boron Neutron Capture Therapy (BNCT) program requires nearby high quality medical facilities. These facilities are not available and are unlikely to be constructed near the Inshas site. Further, the BNCT facility is not correctly designed for advanced research and therapy programs using epithermal neutrons. (b) The ETRR-2 is frequently operated to

  7. Gas Research Institute wetland research program

    International Nuclear Information System (INIS)

    Wilkey, P.L.; Zimmerman, R.E.; Isaacson, H.R.

    1992-01-01

    As part of three ongoing research projects, the Gas Research Institute (GRI) is studying the natural gas industry's impacts on wetlands and how to manage operations so that impacts can be minimized or eliminated. The objective of the first project is to gain a better understanding of the causes and processes of wetland loss in the Louisiana deltaic plain and what role gas pipeline canals play in wetland loss. On the basis of information gathered from the first projects, management and mitigation implications for pipeline construction and maintenance will be evaluated. The objective of the second project is to assess the floral and faunal communities on existing rights-of-way (ROWs) that pass through numerous types of wetlands across the United States. The emphasis of the project is on pipelines that were installed within the past five years. The objective of the third project is to evaluate the administrative, jurisdictional, technical, and economic issues of wetland mitigation banking. This paper discusses these projects, their backgrounds, some of the results to date, and the deliverables

  8. LASL's FY 1978 supporting research program

    International Nuclear Information System (INIS)

    Hammel, E.F.; Merlan, S.J.; Freiwald, D.A.

    1978-09-01

    This report gives a brief overview of Los Alamos Scientific Laboratory's supporting research program, including philosophy, management and program analysis, funding, and a brief description of the kinds of work currently supported. 10 figures

  9. Training program attracts work and health researchers

    DEFF Research Database (Denmark)

    Skakon, Janne

    2007-01-01

    to examining work disability prevention issues. An innovative program that attracts international students, the Work Disability Prevention Canadian Institutes of Health Research (CIHR) Strategic Training Program, aims to build research capacity in young researchers and to create a strong network that examines...

  10. USNRC HTGR safety research program overview

    International Nuclear Information System (INIS)

    Foulds, R.B.

    1982-01-01

    An overview is given of current activities and planned research efforts of the US Nuclear Regulatory Commission (NRC) HTGR Safety Program. On-going research at Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Pacific Northwest Laboratory are outlined. Tables include: HTGR Safety Issues, Program Tasks, HTGR Computer Code Library, and Milestones for Long Range Research Plan

  11. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1986-04-01

    The programs of the Office of Energy Research, DOE, include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The major programs and activities are described briefly, and include high energy and nuclear physics, fusion energy, basic energy sciences, and health and environmental research, as well as advisory, assessment, support, and scientific computing activities

  12. ANSTO - Program of Research 1993-1994

    International Nuclear Information System (INIS)

    1993-01-01

    The 1993-1994 Program of Research outlines ANSTO's scientific activities in four key research areas, Advanced Materials, Application of Nuclear Physics, Biomedicine and Health and Environmental Science. The effort has been channeled into applied research and development in partnership with industry and appropriate national and international institutions and into interdisciplinary strategic research projects to enhance the scientific base of the key research activities. A list of scientific publications originated from these program areas is also included. ills

  13. Maryland controlled fusion research program

    International Nuclear Information System (INIS)

    Griem, H.R.; Liu, C.S.

    1989-07-01

    In recent years, members of the Maryland Plasma Theory Group have made significant contributions to the national fusion theory programs, and, in many cases, these theoretical developments helped to interpret experimental results and to design new experimental programs. In the following, we summarize the technical progress in four major areas: density limit disruptions and sawteeth in tokamaks; anomalous transport in tokamaks; L/H Transition in tokamaks; and magnetic reconnection in compact torus and REP. 9 refs

  14. Safety research program of NUCEF

    International Nuclear Information System (INIS)

    Naito, Y.

    1996-01-01

    To contribute the safety and establishment of advanced technologies in the area of nuclear fuel cycle, Japan Atomic Energy Research Institute (JAERI) has constructed a new research facility NUCEF (Nuclear Fuel Cycle Safety Engineering Research Facility) as the center for the research and development, particularly on the reprocessing technology and transuranium (TRU) waste management. NUCEF consist of three buildings, administration building, experiment building A and B. Building A has two experiment facilities STACY (Static Experiment Critical Facility) and TRACY (Transient Experiment Critical Facility). The experiment building B is referred to as BECKY (Back-end Fuel Cycle Key Elements Research Facility). Researches on the reprocessing and the waste management are carried out with spent fuels, high-level liquid waste, TRU etc. in the α γ cell and glove boxes. NUCEF was constructed with the following aims. Using STACY and TRACY, are aimed, (1) research on advanced technology for criticality safety control, (2) reconfirmation of criticality safety margin of the Rokkasho reprocessing plant. Using BECKY, are aimed, (1) research on advanced technology of reprocessing process, (2) contribution to develop the scenario for TRU waste disposal, (3) development of new technology for TRU partitioning and volume reduction of radioactive waste. To realize the above aims, following 5 research subjects are settled in NUCEF, (1) Criticality safety research, (2) Research on safety and advanced technology of fuel reprocessing, (3) Research on TRU waste management, (4) Fundamental research on TRU chemistry, (5) Key technology development for TRU processing. (author)

  15. Seismic safety research program plan

    International Nuclear Information System (INIS)

    1985-06-01

    This plan describes the safety issues, regulatory needs, and the research necessary to address these needs. The plan also discusses the relationship between current and proposed research within the NRC and research sponsored by other government agencies, universities, industry groups, professional societies, and foreign sources

  16. Seismic safety research program plan

    International Nuclear Information System (INIS)

    1987-05-01

    This document presents a plan for seismic research to be performed by the Structural and Seismic Engineering Branch in the Office of Nuclear Regulatory Research. The plan describes the regulatory needs and related research necessary to address the following issues: uncertainties in seismic hazard, earthquakes larger than the design basis, seismic vulnerabilities, shifts in building frequency, piping design, and the adequacy of current criteria and methods. In addition to presenting current and proposed research within the NRC, the plan discusses research sponsored by other domestic and foreign sources

  17. Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Monti Hughes, A.; Heber, E.M. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Pozzi, E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Department of Research and Production Reactors, Ezeiza Atomic Center, CNEA, Buenos Aires (Argentina); Nigg, D.W. [Idaho National Laboratory, Idaho Falls, Idaho (United States); Calzetta, O.; Blaumann, H.; Longhino, J. [Department of Nuclear Engineering, Bariloche Atomic Center, CNEA, Rio Negro (Argentina); Nievas, S.I. [Department of Chemistry, CNEA, Buenos Aires (Argentina); Aromando, R.F. [Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires (Argentina); Itoiz, M.E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires (Argentina); Trivillin, V.A. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Schwint, A.E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina)], E-mail: schwint@cnea.gov.ar

    2009-07-15

    We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na{sub 2}{sup 10}B{sub 10}H{sub 10}) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. We performed boron biodistribution studies followed by in vivo BNCT studies, with 8 months follow-up. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77-100%. The inhibitory effect of BPA-BNCT and (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.

  18. AECL research programs in chemistry

    International Nuclear Information System (INIS)

    Crocker, I.H.; Eastwood, T.A.; Smith, D.R.; Stewart, R.B.; Tomlinson, M.; Torgerson, D.F.

    1980-09-01

    Fundamental or underlying research in chemistry is being done in AECL laboratories to further the understanding of processes involved in current nuclear energy systems and maintain an awareness of progress at the frontiers of chemical research so that new advances can be turned to advantage in future AECL endeavours. The report introduces the current research topics and describes them briefly under the following headings: radiation chemistry, isotope separation, high temperature solution chemistry, fuel reprocessing chemistry, and analytical chemistry. (auth)

  19. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1984-04-01

    An overview is given for the DOE research programs in high energy and nuclear physics; fusion energy; basic energy sciences; health and environmental research; and advisory, assessment and support activities

  20. Research Award: Innovation for Inclusive Development program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    2011-09-12

    Research Award: Innovation for Inclusive Development program. Deadline: September 12, 2011. Note that all applications must be sent electronically. IDRC offers Research Awards annually to Canadians, permanent residents of. Canada, and citizens of developing countries pursuing master's or doctoral studies.

  1. Summer Undergraduate Breast Cancer Research Program

    National Research Council Canada - National Science Library

    Folk, William R; Blockus, Linda

    2004-01-01

    ... opportunities, preparing for graduate school, and ethics. The 4 SUBCRP students joined the activities of the MU's Life Sciences Undergraduate Research Opportunities Program, including 80 other students involved in a wide variety of research experiences...

  2. Summer Undergraduate Breast Cancer Research Program

    National Research Council Canada - National Science Library

    Folk, William

    2003-01-01

    ... opportunities, preparing for graduate school, and ethics. The 6 SUBCRP students joined the activities of the MU's Life Sciences Undergraduate Research Opportunities Program, including 70 other students involved in a wide variety of research experiences...

  3. A phase-I clinical trial for cranial BNCT at Harvard-MIT

    International Nuclear Information System (INIS)

    Busse, P.M.; Palmer, M.R.; Harling, O.K.

    2000-01-01

    Phase I trial designed to determine the maximum tolerable dose to normal tissue for cranial BNCT (Boron Neutron Capture Therapy) irradiations was recently completed at Harvard Medical School and MIT. Twenty-two subjects diagnosed with either glioblastoma multiforme or intracranial melanoma were treated between 1996 and 1999. Subjects received either one or two administrations of boronophenylalanine intravenously at doses between 250 and 350 mg/kg body weight, then exposed in one, two or three fields to epithermal neutrons at the MIT Research Reactor in one or two fractions. Over the course of the study, the maximum normal tissue dose target was increased from 8.8 to 14.2 RBE (Relative Biological Effectiveness) Gy in 10% increments. Subjects have been followed clinically and radiographically. Of those patients surviving beyond six months, no MRI (Magnetic Resonance Image) white-matter changes were observed and no long-term complications attributable to BNCT were evident. Tumor responses were observed, particularly with the melanoma subjects. With increasing doses, difficulties arose from long irradiation times (approximately 3 hours) and the emergence of acute reactions in the skin and mucosa. The trial was stopped in May 1999. Future trials will be initiated with the new high intensity, low background fission converter beam at MIT. (author)

  4. Animal Resource Program | Center for Cancer Research

    Science.gov (United States)

    CCR Animal Resource Program The CCR Animal Resource Program plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. The ARP Manager:

  5. Accreditation to manage research programs

    International Nuclear Information System (INIS)

    Miramand, Pierre

    1993-01-01

    In this report for an accreditation to supervise research, the author proposes an overview of a study of transfers of vanadium towards benthic organisms (i.e. the toxicity of vanadium for sea coastal organisms), of studies of transfer of transuranic elements from sediment to marine benthic species. He presents current researches and perspectives: study of the level of metallic pollutants and physical-chemical characteristics of coastal waters in northern Cotentin, researches in Seine Bay, study of pollution biologic indicators. Numerous articles are provided in appendix

  6. Aquatic Plant Control Research Program

    National Research Council Canada - National Science Library

    Cofrancesco, Alfred

    1998-01-01

    .... This search for natural plant enemies (insects and fungal pathogens) has led researchers to the native ranges of noxious aquatic plants, located throughout the continents of Africa, Asia, Europe, and Australia...

  7. Theoretical Particle Physics Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Paz, Gil [Wayne State Univ., Detroit, MI (United States)

    2015-06-23

    This is the final technical report for DOE grant DE-FG02-13ER41997. It contains a brief description of accomplishments: research project that were completed during the period of the grant, research project that were started during the period of the grant, and service to the scientific community. It also lists the publications in the funded period, travel related to the grant, and information about the personal supported by the grant.

  8. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  9. The NASA Space Radiation Research Program

    Science.gov (United States)

    Cucinotta, Francis A.

    2006-01-01

    We present a comprehensive overview of the NASA Space Radiation Research Program. This program combines basic research on the mechanisms of radiobiological action relevant for improving knowledge of the risks of cancer, central nervous system and other possible degenerative tissue effects, and acute radiation syndromes from space radiation. The keystones of the NASA Program are five NASA Specialized Center's of Research (NSCOR) investigating space radiation risks. Other research is carried out through peer-reviewed individual investigations and in collaboration with the US Department of Energies Low-Dose Research Program. The Space Radiation Research Program has established the Risk Assessment Project to integrate data from the NSCOR s and other peer-reviewed research into quantitative projection models with the goals of steering research into data and scientific breakthroughs that will reduce the uncertainties in current risk projections and developing the scientific knowledge needed for future individual risk assessment approaches and biological countermeasure assessments or design. The NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory was created by the Program to simulate space radiation on the ground in support of the above research programs. New results from NSRL will be described.

  10. Research program in particle physics

    International Nuclear Information System (INIS)

    Sudarshan, E.C.G.; Dicus, D.A.; Ritchie, J.L.; Lang, K.

    1993-05-01

    This report is the progress report for DOE funded support of particle physics work at the University of Texas, Austin. Support was divided between theoretical and experimental programs, and each is reviewed separately in the report. Theoretical effort was divided between three general areas: quantum gravity and mathematical physics; phenomenology; and quantum mechanics and quantum field theory. Experimental effort was primarily directed toward AGS experiments at Brookhaven, to look for rare kaon decays. AGS experiments 791 and 871 are described, along with BNL experiment 888

  11. 2016 Research Outreach Program report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Young [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kim, Yangkyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-13

    This paper is the research activity report for 4 weeks in LANL. Under the guidance of Dr. Lee, who performs nuclear physics research at LANSCE, LANL, I studied the Low Energy NZ (LENZ) setup and how to use the LENZ. First, I studied the LENZ chamber and Si detectors, and worked on detector calibrations, using the computer software, ROOT (CERN developed data analysis tool) and EXCEL (Microsoft office software). I also performed the calibration experiments that measure alpha particles emitted from a Th-229 source by using a S1-type detector (Si detector). And with Dr. Lee, we checked the result.

  12. Nebraska Prostate Cancer Research Program

    Science.gov (United States)

    2015-10-01

    Khan then phoned Dr. Lin regarding the conclusion of meeting with students’ evaluation and expressed students’ positive attitude toward research...nitrocellulose membrane, membranes were blocked with 5% non-fat milk Novel Imidazopyridines in Castration-Resistant Prostate Cancer PLOS ONE | DOI

  13. Overview of Gas Research Institute environmental research programs

    International Nuclear Information System (INIS)

    Evans, J.M.

    1991-01-01

    The Gas Research Institute (GRI) is a private not-for-profit membership organization of natural gas pipelines, distribution companies and natural gas producers. GRI's purpose is to plan, to manage and to develop financing for a gas-related research and development (R and D) program on behalf of its members and their customers. GRI does not do any research itself. GRI's R and D program is designed to provide advanced technologies for natural gas supply, transport, storage, distribution and end-use applications in all markets. In addition, basic research is conducted for GRI in these areas to build a foundation for future technology breakthroughs. Work in the Environment and Safety Research Department includes sections interested in: supply related research, air quality research, end use equipment safety research, gas operations safety research, and gas operations environmental research. The Natural Gas Supply Program has research ongoing in such areas as: restoration of pipeline right-of-ways; cleaning up town gas manufacturing sites; the development of methanogenic bacteria for soil and groundwater cleanup; development of biological fluidized carbon units for rapid destruction of carbonaceous compounds; research on liquid redox sulfur recovery for sulfur removal from natural gas; research on produced water and production wastes generated by the natural gas industry; environmental effects of coalbed methane production; and subsurface effects of natural gas operations. The western coalbed methane and ground water programs are described

  14. Research results of the Optimiturve research program in 1991

    International Nuclear Information System (INIS)

    Alakangas, E.

    1992-01-01

    Optimiturve research program is one of the energy research programs funded by the Ministry of Trade and Industry of Finland. The main target of the program is double the annual hectare yield of peat dried by solar radiation to decrease the peat production costs, to speed up the circulation of capital invested to peat production with the aid of a new production method developed in this research, and hence improve the price competitivity of peat. The targets of the research program are expected to be completed by improving the drying of peat, the efficiency of the peat production machinery, and by developing peat production techniques. The program was started in 1988, and the targets are to be fulfilled up to year 1993. The research program is carried out in cooperation with universities, research organizations and peat producers. This publication consists of the results of the ongoing projects in the Optimiturve research program in 1991. The aim, the contents and the main results of the 18 projects are presented. At the end of this publication there is a list of the reports published in Reports series

  15. Thermal hydraulic design features for the BNCT application. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Blue, T.E.; Vafai, K.

    1993-06-01

    This project report is based on our investigations for thermal design of a heat pipe for removing generated heat resulting from Proton bombardments of a Lithium target for a BNCT application. In our investigation, an integral analysis was employed to investigate the vapor an liquid flow in a flat plate heat pipe heated asymmetrically for removal of the 75 kW generated from the BNCT application. The flat plate heat pipe configuration will be used for removing the heat which is generated as a result of proton bombardment of the lithium target. The working fluid in the heat pipe occurs in two phase namely liquid and vapor. The wick contains all the liquid phase and the vapor phase is mainly in the core region. Heat is applied by an external source at the evaporator section which vaporizes the working fluid in this section. This results in a pressure difference which drives the vapor to the condenser section where condenses and releases latent heat of vaporization to a heat sink in the condense section. Due to the vaporization of liquid in the evaporator, the liquid-vapor interface enters into the wick surface and hence capillary pressure is developed there. This capillary pressure causes the condensed liquid in the condenser to be pumped back to the evaporator again. The results of our investigation have enabled us to correlate such diverse information as; the thickness of the wick, the diameter of the heat pipe, the wetting angle, the capillary radius, the surface tension, the latent heat of evaporation, the permeability and porosity of the chosen wick, the length of the heat pipe, and the viscosity and density of the two phases; with the heat removal capabilities of the heat pipe. Expressions for the pressure and velocity distributions are obtained and discussed in relation to our application to BNCT. The present design clearly shows that it is possible to attain temperatures well below the melting temperature of the lithium in the BNCT application.

  16. Environmental research program: FY 1987, annual report

    Energy Technology Data Exchange (ETDEWEB)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups.

  17. Environmental research program: FY 1987, annual report

    International Nuclear Information System (INIS)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups

  18. Boron Neutron Capture Therapy at the TRIGA Mark II of Pavia, Italy - The BNCT of the diffuse tumours

    International Nuclear Information System (INIS)

    Altieri, S.; Bortolussi, S.; Stella, S.; Bruschi, P.; Gadan, M.A.

    2008-01-01

    The selectivity based on the B distribution rather than on the irradiation field makes Boron neutron Capture Therapy (BNCT) a valid option for the treatment of the disseminated tumours. As the range of the high LET particles is shorter than a cell diameter, the normal cells around the tumour are not damaged by the reactions occurring in the tumoral cells. PAVIA 2001: first treatment of multiple hepatic metastases from colon ca by BNCT and auto-transplantation technique: TAOrMINA project. The liver was extracted after BPA infusion, irradiated in the Thermal Column of the Pavia TRIGA Mark II reactor, and re-implanted in the patient. Two patients were treated, demonstrating the feasibility of the therapy and the efficacy in destroying the tumoral nodules sparing the healthy tissues. In the last years, the possibility of applying BNCT to the lung tumours using epithermal collimated neutron beams and without explanting the organ, is being explored. The principal obtained results of the BNCT research are presented, with particular emphasis on the following aspects: a) the project of a new thermal column configuration to make the thermal neutron flux more uniform inside the explanted liver, b) the Monte Carlo study by means of the MCNP code of the thermal neutron flux distribution inside a patient's thorax irradiated with epithermal neutrons, and c) the measurement of the boron concentration in tissues by (n,α) spectroscopy and neutron autoradiography. The dose distribution in the thorax are simulated using MCNP and the anthropomorphic model ADAM. To have a good thermal flux distribution inside the lung epithermal neutrons must be used, which thermalize crossing the first tissue layers. Thermal neutrons do not penetrate and the obtained uniformity is poor. In the future, the construction of a PGNAA facility using a horizontal channel of the TRIGA Mark II is planned. With this method the B concentration can be measured also in liquid samples (blood, urine) and in those

  19. Optimization of the application of BNCT to undifferentiated thyroid cancer

    International Nuclear Information System (INIS)

    Dagrosa, M.A.; Thomasz, L.; Longhino, J.

    2006-01-01

    The possible increase in BNCT efficacy for undifferentiated thyroid carcinoma (UTC) using BPA plus BOPP and nicotinamide (NA) as a radiosensitizer on the BNCT reaction was analyzed. In these studies nude mice were transplanted with the ARO cells and after 14 days they were treated as follows: 1) Control; 2) NCT (neutrons alone); 3) NCT plus NA (100 mg/kg bw/day for 3 days); 4) BPA (350 mg/kg bw) + neutrons; 5) BPA+ NA+ neutrons; 6) BPA+BOPP (60 mg/kg bw) + neutrons. The flux of hyperthermal neutrons was 2.8 10 8 during 85 min. Neutrons alone or with NA caused some tumor growth delay, while in the BPA, BPA+NA and BPA+BOPP groups a 100% halt of tumor growth was observed. When the initial tumor volume was 50 mm 3 or less a complete cure was found in BPA+NA (2/2); BPA (1/4); BPA+BOPP (7/7). After 90 days of complete regression, recurrence of tumor was observed in 2/2 BPA/NA (2/2) and BPA+BOPP (1/7). Caspase 3 activity was increased in BPA+NA (p<0.05 vs controls). BPA plus NA increased tumor apoptosis but only the combination of BPA+BOPP increased significantly BNCT efficiency. (author)

  20. In vitro biological models in order to study BNCT

    International Nuclear Information System (INIS)

    Dagrosa, Maria A.; Kreimann, Erica L.; Schwint, Amanda E.; Juvenal, Guillermo J.; Pisarev, Mario A.; Farias, Silvia S.; Garavaglia, Ricardo N.; Batistoni, Daniel A.

    1999-01-01

    Undifferentiated thyroid carcinoma (UTC) lacks an effective treatment. Boron neutron capture therapy (BNCT) is based on the selective uptake of 10 B-boronated compounds by some tumours, followed by irradiation with an appropriate neutron beam. The radioactive boron originated ( 11 B) decays releasing 7 Li, gamma rays and alpha particles, and these latter will destroy the tumour. In order to explore the possibility of applying BNCT to UTC we have studied the biodistribution of BPA. In vitro studies: the uptake of p- 10 borophenylalanine (BPA) by the UTC cell line ARO, primary cultures of normal bovine thyroid cells (BT) and human follicular adenoma (FA) thyroid was studied. No difference in BPA uptake was observed between proliferating and quiescent ARO cells. The uptake by quiescent ARO, BT and FA showed that the ARO/BT and ARO/FA ratios were 4 and 5, respectively (p< 0.001). The present experimental results open the possibility of applying BNCT for the treatment of UTC. (author)

  1. A Tandem-electrostatic-quadrupole for accelerator-based BNCT

    International Nuclear Information System (INIS)

    Kreiner, A.J.; Kwan, J.W.; Burlon, A.A.; Di Paolo, H.; Henestroza, E.; Minsky, D.M.; Valda, A.A.; Debray, M.E.; Somacal, H.

    2007-01-01

    A project to develop a Tandem-electrostatic-quadrupole (TESQ) accelerator for accelerator-based boron neutron capture therapy (AB-BNCT) is described. A folded Tandem, with 1.25 MV terminal voltage, combined with an electrostatic quadrupole (ESQ) chain is being proposed. The project goal is a machine capable of delivering 30 mA of 2.5 MeV protons to be used in conjunction with a neutron production target based on the 7 Li(p, n) 7 Be reaction slightly beyond its resonance at 2.25 MeV. This machine is conceptually shown to be capable of accelerating a 30 mA proton beam to 2.5 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the 7 Li(p, n) 7 Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. This electrostatic machine is the technologically simplest and cheapest solution for optimized AB-BNCT

  2. Clinical results of BNCT for malignant brain tumors in children

    International Nuclear Information System (INIS)

    Nakagawa, Yoshinobu; Kageji, Teruyoshi; Mizobuchi, Yoshifumi; Kumada, Hiroaki; Nakagawa, Yoshiaki

    2009-01-01

    It is very difficult to treat the patients with malignant brain tumor in children, especially under 3 years, because the conventional irradiation cannot be applied due to the damage of normal brain tissue. However, boron neutron capture therapy (BNCT) has tumor selectivity such that it can make damage only in tumor cells. We evaluated the clinical results and courses in patients with malignant glioma under 15 years. Among 183 patients with brain tumors treated by our group using BSH-based intra-operative BNCT, 23 patients were under 15 years. They included 4 patients under 3 years. There were 3 glioblastomas (GBM), 6 anaplastic astrocytomas(AAS), 7 primitive neuroectodermal tumors (PNET), 6 pontine gliomas and 1 anaplastic ependymoma. All GBM and PNET patients died due to CSF and/or CNS dissemination without local tumor regrowth. All pontine glioma patients died due to regrowth of the tumor. Four of 6 anaplastic astrocytoma and 1 anaplastic ependymoma patients alive without tumor recurrence. BNCT can be applied to malignant brain tumors in children, especially under 3 years instead of conventional radiation. Although it can achieve the local control in the primary site, it cannot prevent CSF dissemination in patients with glioblastoma.

  3. Review of fusion research program: historical summary and program projections

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, E.S.

    1976-09-01

    This report provides a brief review of the history and current status of fusion research in the United States. It also describes the Federally funded program aimed at the development of fusion reactors for electric power generation.

  4. Summer Undergraduate Research Program: Environmental studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J. [ed.

    1994-12-31

    The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. The students are offered research topics at the Medical University in the scientific areas of pharmacology and toxicology, epidemiology and risk assessment, environmental microbiology, and marine sciences. Students are also afforded the opportunity to work with faculty at the University of Charleston, SC, on projects with an environmental theme. Ten well-qualified students from colleges and universities throughout the eastern United States were accepted into the program.

  5. GAS INDUSTRY GROUNDWATER RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    James A. Sorensen; John R. Gallagher; Steven B. Hawthorne; Ted R. Aulich

    2000-10-01

    The objective of the research described in this report was to provide data and insights that will enable the natural gas industry to (1) significantly improve the assessment of subsurface glycol-related contamination at sites where it is known or suspected to have occurred and (2) make scientifically valid decisions concerning the management and/or remediation of that contamination. The described research was focused on subsurface transport and fate issues related to triethylene glycol (TEG), diethylene glycol (DEG), and ethylene glycol (EG). TEG and DEG were selected for examination because they are used in a vast majority of gas dehydration units, and EG was chosen because it is currently under regulatory scrutiny as a drinking water pollutant. Because benzene, toluene, ethylbenzene, and xylenes (collectively referred to as BTEX) compounds are often very closely associated with glycols used in dehydration processes, the research necessarily included assessing cocontaminant effects on waste mobility and biodegradation. BTEX hydrocarbons are relatively water-soluble and, because of their toxicity, are of regulatory concern. Although numerous studies have investigated the fate of BTEX, and significant evidence exists to indicate the potential biodegradability of BTEX in both aerobic and anaerobic environments (Kazumi and others, 1997; Krumholz and others, 1996; Lovely and others, 1995; Gibson and Subramanian, 1984), relatively few investigations have convincingly demonstrated in situ biodegradation of these hydrocarbons (Gieg and others, 1999), and less work has been done on investigating the fate of BTEX species in combination with miscible glycols. To achieve the research objectives, laboratory studies were conducted to (1) characterize glycol related dehydration wastes, with emphasis on identification and quantitation of coconstituent organics associated with TEG and EG wastes obtained from dehydration units located in the United States and Canada, (2) evaluate

  6. University Research Consortium annual review meeting program

    International Nuclear Information System (INIS)

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators

  7. University Research Consortium annual review meeting program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators.

  8. Environmental research program. 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    The objective of the Environmental Research Program is to contribute to the understanding of the formation, mitigation, transport, transformation, and ecological effects of energy-related pollutants on the environment. The program is multidisciplinary and includes fundamental and applied research in chemistry, physics, biology, engineering, and ecology. The program undertakes research and development in efficient and environmentally benign combustion, pollution abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group investigates combustion, atmospheric processes, flue-gas chemistry, and ecological systems.

  9. Natural and accelerated bioremediation research program plan

    International Nuclear Information System (INIS)

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE's Office of Environmental Management (EM). The program builds on OHER's tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER's and Office of Energy Research's (OER's) commitment to supporting DOE's environmental management mission and the belief that bioremediation is an important part of the solution to DOE's environmental problems

  10. International Community-University Research Alliance Program ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The International Community-University Research Alliance program (ICURA) is a joint initiative of the Social Sciences and Humanities Research Council (SSHRC) and IDRC. ICURA seeks to foster innovative research, training and the creation of new knowledge in areas of importance to the social, cultural and economic ...

  11. Small business innovation research program solicitation

    Science.gov (United States)

    1994-01-01

    The National Aeronautics and Space Administration invites eligible small business concerns to submit Phase 1 proposals for its 1994 Small Business Innovation Research (SBIR) Program, which is described in this twelfth annual NASA SBIR Program Solicitation. The 1994 solicitation period for Phase 1 proposals begins April 4, 1994 and ends June 15, 1994. Eligible firms with research or research and development capabilities (R/R&D) in any of the listed topic and subtopic areas are encouraged to participate. Through SBIR, NASA seeks innovative concepts addressing the program needs described in the SBIR solicitation subtopics and offering commercial application potential. This document contains program background information, outlines eligibility requirements for SBIR participants, describes the three SBIR program phases, and provides the information qualified offerors need to prepare and submit responsive proposals.

  12. Structural Metadata Research in the Ears Program

    National Research Council Canada - National Science Library

    Liu, Yang; Shriberg, Elizabeth; Stolcke, Andreas; Peskin, Barbara; Ang, Jeremy; Hillard, Dustin; Ostendorf, Mari; Tomalin, Marcus; Woodland, Phil; Harper, Mary

    2005-01-01

    Both human and automatic processing of speech require recognition of more than just words. In this paper we provide a brief overview of research on structural metadata extraction in the DARPA EARS rich transcription program...

  13. Second program on energy research and technologies

    Science.gov (United States)

    1982-10-01

    The second major energy research and development program is described. Renewable and nonrenewable energy resources are presented which include nuclear technology and future energy sources, like fusion. The current status and outlook for future progress are given.

  14. Environmental Research Division's Data Access Program (ERDDAP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ERDDAP (the Environmental Research Division's Data Access Program) is a data server that gives you a simple, consistent way to download subsets of scientific...

  15. Research for International Tobacco Control (RITC) : Program ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Department for International Development (DFID), United Kingdom, is making a grant of up to £1 100 000 to IDRC to cover three years of Research for International Tobacco Control (RITC) programming between April 2005 and March 2008. The funding is intended to support activities outlined in RITC's program ...

  16. Research Review: Laboratory Student Magazine Programs.

    Science.gov (United States)

    Wheeler, Tom

    1994-01-01

    Explores research on student-produced magazines at journalism schools, including the nature of various programs and curricular structures, ethical considerations, and the role of faculty advisors. Addresses collateral sources that provide practical and philosophical foundations for the establishment and conduct of magazine production programs.…

  17. New energy technologies. Research program proposition

    International Nuclear Information System (INIS)

    2005-02-01

    This document presents the most promising program propositions of research and development and the public financing needed for their realization. The concerned technologies are: the hydrogen and the fuel cell PAN-H, the separation and the storage of the CO 2 , the photovoltaic solar electricity, the PREBAT program of the building energy recovery and the bio-energies. (A.L.B.)

  18. NASA Small Business Innovation Research program

    Science.gov (United States)

    Johnson, Harry W.

    1985-01-01

    NASA activities in the framework of the 11-agency federal Small Business Innovation Research program are outlined in tables and graphs and briefly characterized. Statistics on the program are given; the technical topics covered are listed; and the procedures involved in evaluating applications for support are discussed. A number of typical defects in proposals are indicated, and recommendations for avoiding them are provided.

  19. Research on Effectiveness of Sex Education Programs.

    Science.gov (United States)

    Kirby, Douglas

    1989-01-01

    This article reviews the research on sexuality education programs. It examines the more significant studies that have evaluated the actual impact of those programs on various outcomes, including knowledge, attitudes, skills, and sexual behaviors. It finds that behavior is difficult to change and suggests specific approaches that appear promising.…

  20. AECL programs in basic physics research

    International Nuclear Information System (INIS)

    Bartholomew, G.A.; Dolling, G.; Harvey, M.; Milton, J.C.D.

    1982-02-01

    This report describes the CRNL program of research into the basic properties of atomic nuclei and condensed matter (liquids and solids). Brief descriptions are given of some of the current experimental programs done principally at the NRU reactor and MP tandem accelerator, the associated theoretical studies, and some highlights of past achievements

  1. Training program attracts work and health researchers

    DEFF Research Database (Denmark)

    Skakon, Janne

    2007-01-01

    to examining work disability prevention issues. An innovative program that attracts international students, the Work Disability Prevention Canadian Institutes of Health Research (CIHR) Strategic Training Program, aims to build research capacity in young researchers and to create a strong network that examines......Each year in Canada, the costs of disability arising from work-related causes – including workers’ compensation and health-care costs – exceed $6.7 billion. Despite the significant financial and social impacts of worker injury and illness, only a small fraction of Canadian researchers are dedicated...

  2. Follow up of glioblastoma patients treated with BNCT using spectroscopic imaging

    International Nuclear Information System (INIS)

    Kankaanranta, L.; Haekkinen, A.M.; Kivisaari, L.; Lundbom, N.; Joensuu, H.; Seppaelae, T.

    2000-01-01

    The aim of the study was to investigate the metabolite changes of BPA-mediated BNCT on glioblastoma multiforme (GBM) and on brain white matter with proton magnetic spectroscopic imaging ( 1 H-MRSI). Four glioblastoma patients treated with BNCT were been examined with both MRI and 1 H-MRSI before BNCT and at 3-month intervals following BNCT. We found no change in the choline (Cho) of the tumors of 2 patients 3 months after BNCT, but at 6 months the choline increased in agreement with clinically observed progression of glioblastomas. No N-acetylaspartate (NAA) changes were found in the normal appearing white matter in 3 patients. Unexpectedly, choline changes were seen in both ipsi- and contralateral white matter regions. The small number of patients studied prevents making firm conclusions, but 1 H-MRSI may be a useful method in follow-up of patients treated with BNCT and deserves further study. Presence of only minimal NAA changes in some patients treated with BNCT is intriguing, and may suggest absence of marked neuronal damage within the first 6 months following BNCT treatment when average brain doses <5.2 Gy (W) are used. (author)

  3. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  4. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1985-07-01

    The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The current organization of ER is shown. The budgets for the various ER programs for the last two fiscal years are shown. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large

  5. Research Ethics with Undergraduates in Summer Research Training Programs

    Science.gov (United States)

    Cheung, I.; Yalcin, K.

    2016-02-01

    Many undergraduate research training programs incorporate research ethics into their programs and some are required. Engaging students in conversations around challenging topics such as conflict of interest, cultural and gender biases, what is science and what is normative science can difficult in newly formed student cohorts. In addition, discussing topics with more distant impacts such as science and policy, intellectual property and authorship, can be difficult for students in their first research experience that have more immediate concerns about plagiarism, data manipulation, and the student/faculty relationship. Oregon State University's Research Experience for Undergraduates (REU) in Ocean Sciences: From Estuaries to the Deep Sea as one model for incorporating a research ethics component into summer undergraduate research training programs. Weaved into the 10-week REU program, undergraduate interns participate in a series of conversations and a faculty mentor panel focused on research ethics. Topics discussed are in a framework for sharing myths, knowledge and personal experiences on issues in research with ethical implications. The series follows guidelines and case studies outlined from the text, On Being A Scientist: Responsible Conduct In Research Committee on Science, Engineering, and Public Policy, National Academy of Sciences.

  6. Health, safety and environmental research program

    International Nuclear Information System (INIS)

    Dinner, P.J.

    1983-01-01

    This report outlines the Health, Safety and Environmental Research Program being undertaken by the CFFTP. The Program objectives, relationship to other CFFTP programs, implementation plans and expected outputs are stated. Opportunities to build upon the knowledge and experience gained in safely managing tritium in the CANDU program, by addressing generic questions pertinent to tritium safety for fusion facilities, are identified. These opportunities exist across a broad spectrum of issues covering the anticipated behaviour of tritium in fusion facilities, the surrounding environment and in man

  7. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1992-09-01

    The programs of the Office of Energy Research provide basic science support for energy technologies as well as advancing understanding in general science and training future scientists. Energy Research provides insights into fundamental science and associated phenomena and develops new or advanced concepts and techniques. Research of this type has been supported by the Department of Energy and its predecessors for over 40 years and includes research in the natural and physical sciences, including high energy and nuclear physics; magnetic fusion energy; biological and environmental research; and basic energy sciences research in the materials, chemical, and applied mathematical sciences, engineering and geosciences, and energy biosciences. These basic research programs help build the science and technology base that underpins energy development by Government and industry

  8. Regulatory research program for 1987/88

    International Nuclear Information System (INIS)

    1987-01-01

    The regulatory research program of Canada's Atomic Energy Control Board (AECB) is intended to augment the AECB's research program beyond the capability of in-house resources. The overall objective of the research program is to produce pertinent and independent information that will assist the Board and its staff in making correct, timely and credible decisions on regulating nuclear energy. The program covers the following areas: the safety of nuclear facilities, radioactive waste management, health physics, physical security, and the development of regulatory processes. Sixty-seven projects are planned for 1987/88; as well, there are some projects held in reserve in case funding becomes available. This information bulletin contains a list of the projects with a brief description of each

  9. Research Award: Agriculture and Food Security Program

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    2014-08-06

    Research Award: Agriculture and Food Security. Program. Deadline: August 6, 2014. Please note that all applications must be submitted online. IDRC is one of the world's leaders in generating new knowledge to meet global challenges. We offer a number of research awards providing a unique opportunity to enhance ...

  10. A program of watershed-management research

    Science.gov (United States)

    Howard W. Lull; Irvin C. Reigner

    1957-01-01

    This is a proposed 5-point, 5-year program for watershed-management research at the Kingston Research Center. This Center's area embraces 5 counties in southern New York and 18 counties in northeastern Pennsylvania, an aggregate of 10,247,000 acres or about 16,000 square miles. Its long axis (northeast to southwest) is about 250 miles long, and its breadth...

  11. Program of research 1988-89

    International Nuclear Information System (INIS)

    1988-08-01

    From 1 July 1988, the research activities of ANSTO have reorganised into five programs: advanced materials; applications of nuclear physics; environmental science; applications of radioisotopes and radiation; biomedicine and health. This structure not only groups the main research activities but also identifies the underpinning of ANSTO's commercial activities. This document describes the projects to be undertaken in the 1988-89 financial year. Each project in a particular program area is defined in terms of background, objective, recent work and achievements, work planned, resources and the project manager is identified. Research is also undertaken in areas of the operational activities of the organisation and these also are detailed

  12. Natural and accelerated bioremediation research program plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE`s Office of Environmental Management (EM). The program builds on OHER`s tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER`s and Office of Energy Research`s (OER`s) commitment to supporting DOE`s environmental management mission and the belief that bioremediation is an important part of the solution to DOE`s environmental problems.

  13. 75 FR 15756 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2010-03-30

    ... SMALL BUSINESS ADMINISTRATION RIN 3244-AF61 Small Business Innovation Research Program Policy.... SUMMARY: This document announces a final amendment to the Small Business Innovation Research (SBIR... Research Program To: The Directors, Small Business Innovation Research (SBIR) Program Subject: Final...

  14. Analysis of accelerator based neutron spectra for BNCT using proton recoil spectroscopy

    International Nuclear Information System (INIS)

    Wielopolski, L.; Ludewig, H.; Powell, J.R.; Raparia, D.; Alessi, J.G.; Lowenstein, D.I.

    1998-01-01

    Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by 10 B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase I/II clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based neutron beam energy spectra alternative neutron sources are being contemplated for wider implementation of this modality in a hospital environment. For example, accelerator based neutron sources offer the possibility of tailoring the neutron beams, in terms of improved depth-dose distributions, to the individual and offer, with relative ease, the capability of modifying the neutron beam energy and port size. In previous work new concepts for compact accelerator/target configuration were published. In this work, using the Van de Graaff accelerator the authors have explored different materials for filtering and reflecting neutron beams produced by irradiating a thick Li target with 1.8 to 2.5 MeV proton beams. However, since the yield and the maximum neutron energy emerging from the Li-7(p,n)Be-7 reaction increase with increase in the proton beam energy, there is a need for optimization of the proton energy versus filter and shielding requirements to obtain the desired epithermal neutron beam. The MCNP-4A computer code was used for the initial design studies that were verified with benchmark experiments

  15. Summer Prostate Cancer Research Training Program

    Science.gov (United States)

    2017-09-01

    the research program by each mentor will certainly produce important research findings, aided in part by the summer research of the ...adenovirus vaccine in men with prostate cancer. Important in these trials is the safety of the vaccine and its ability to induce anti-tumor immunity... Living in Iowa City for the Summer Housing and Meals - All students will be housed in the Mayflower Residence Hall on the Campus of the University

  16. Base Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2008-06-30

    The main objective of the Base Research Program was to conduct both fundamental and applied research that will assist industry in developing, deploying, and commercializing efficient, nonpolluting fossil energy technologies that can compete effectively in meeting the energy requirements of the Nation. In that regard, tasks proposed under the WRI research areas were aligned with DOE objectives of secure and reliable energy; clean power generation; development of hydrogen resources; energy efficiency and development of innovative fuels from low and no-cost sources. The goal of the Base Research Program was to develop innovative technology solutions that will: (1) Increase the production of United States energy resources--coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. This report summarizes the accomplishments of the overall Base Program. This document represents a stand-alone Final Report for the entire Program. It should be noted that an interim report describing the Program achievements was prepared in 2003 covering the progress made under various tasks completed during the first five years of this Program.

  17. ANSTO - program of research 1991-1992

    International Nuclear Information System (INIS)

    1991-01-01

    The direction and priorities of the Australian Nuclear Science and Technology Organisation (ANSTO) research program are outlined. During the period under review. Many of the initiatives of previous years come to fruition, adding significant strength and dimension to the Organisation's research capabilities. The advent of Australian Supercomputing Technology, a joint venture between Fujitsu Australia and ANSTO, will enable the grand challenges of computational science to underpin Ansto research generally but specifically in environmental science. The development of the accelerator mass spectrometry facilities on the tandem accelerator supported new initiatives in environmental research and management. The National Medical Cyclotron opens a new era in radiopharmaceutical research and development. Finally, the recently commissioned hot isostatic press provides a unique national resource for the development of new ceramics and their applications. The direction and priorities of Ansto's research program are determined through a combination of external and internal review. The Program Advisory Committees provide external evaluation against national objectives. New Committees have been formed and membership reflects the national and international nature of the ANSTO research programs. ills

  18. A core laboratory offering full evaluation of new boron compounds. A service to the BNCT community

    International Nuclear Information System (INIS)

    Zamenhof, R.G.; Patel, H.; Palmer, M.R.; Lin, H.C.; Busse, P.M.; Harling, O.; Binns, P.J.; Riley, K.J.; Bernard, J.

    2000-01-01

    A joint project by the Beth Israel Deaconess Medical Center at Harvard Medical School and The Nuclear Reactor Laboratory of the Massachusetts Institute of Technology is proposed which would provide a core laboratory for the evaluation of new boron compounds. Federal agency funding has been applied for to support such a facility. The facility's evaluation of candidate boron compounds will include: quantitative cellular boron uptake; cell survival curve analysis (using a thermal neutron beam); small or large animal pharmacokinetic analysis; macro- and micro boron distribution analysis using high-resolution autoradiography, prompt gamma analysis and ICP-AES; small or large animal in vivo tumor control studies (using thermal or epithermal neutron beams); and pharmacological in vivo toxicity evaluation. The laboratory will include small and large animal surgical facilities and resources for additional boron compound chemistry as required by the evaluation procedure. This facility will be open to the BNCT research community. (author)

  19. Neutron field characterization in the installation for BNCT study in the IEA-R1 reactor; Caracterizacao do campo de neutrons na instalacao para estudo em BNCT no reator IEA-R1

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro Junior, Valdeci

    2008-07-01

    This work aims to characterize the mixed neutron and gamma field, in the sample irradiation position, in a research installation for Boron Neutron Capture Therapy (BNCT), in the IPEN IEA-R1 reactor. The BNCT technique has been studied as a safe and selective option in the treatment of resistant cancerigenous tumors or considered non-curable by the conventional techniques, for example, the Glioblastoma Multiform - a brain cancerigenous tumor. Neutron flux measurements were carried out: thermal, resonance and fast, as well as neutron and gamma rays doses, in the sample position, using activation foils detectors and thermoluminescent dosimeters. For the determination of the neutron spectrum and intensity, a set of different threshold activation foils and gold foils covered and uncovered with cadmium irradiated in the installation was used, analyzed by a high Pure Germanium semiconductor detector, coupled to an electronic system suitable for gamma spectrometry. The results were processed with the SAND-BP code. The doses due to gamma and neutron rays were determined using thermoluminescent dosimeters TLD 400 and TLD 700 sensitive to gamma and TLD 600, sensitive to neutrons. The TLDs were selected and used for obtaining the calibration curves - dosimeter answer versus dose - from each of the TLD three types, which were necessary to calculate the doses due to neutron and gamma, in the sample position. The radiation field, in the sample irradiation position, was characterized flux for thermal neutrons of 1.39.10{sup 8} {+-} 0,12.10{sup 8} n/cm{sup 2}s the doses due to thermal neutrons are three times higher than those due to gamma radiation and confirm the reproducibility and consistency of the experimental findings obtained. Considering these results, the neutron field and gamma radiation showed to be appropriated for research in BNCT. (author)

  20. Dynamic infrared imaging of cutaneous melanoma and normal skin in patients treated with BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Santa Cruz, G.A. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina)], E-mail: santacr@cnea.gov.ar; Bertotti, J.; Marin, J. [Universidad Favaloro, Solis 453 (1078), Buenos Aires (Argentina); Gonzalez, S.J. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina); CONICET, Avda. Rivadavia 1917 (1033), Buenos Aires (Argentina); Gossio, S. [FCEyN, Pabellon II, Ciudad Universitaria (1428), Buenos Aires (Argentina); Alvarez, D. [Fundacion Favaloro, Av. Belgrano 1746 (1093), Buenos Aires (Argentina); Roth, B.M.C.; Menendez, P. [Instituto de Oncologia Angel H. Roffo, Av. San Martin 5481 (1417), Buenos Aires (Argentina); Pereira, M.D. [Agencia Nacional de Promocion Cientifica y Tecnologica, PAV 22393 (Argentina); Albero, M.; Cubau, L.; Orellano, P. [INVAP S.E., F.P. Moreno 1089 (R8400AMU), S.C. de Bariloche, Rio Negro (Argentina); Liberman, S.J. [Dpto. de Instrumentacion y Control, Comision Nacional de Energia Atomica, Av. del Libertador 8250 (1429), Buenos Aires (Argentina)

    2009-07-15

    We recently initiated a program aimed to investigate the suitability of dynamic infrared imaging for following-up nodular melanoma patients treated with BNCT. The reason that makes infrared imaging attractive is the fact that it constitutes a functional and non-invasive imaging method, providing information on the normal and abnormal physiologic response of the nervous and vascular systems, as well as the local metabolic rate and inflammatory processes that ultimately appear as differences in the skin temperature. An infrared camera, with a focal plane array of 320x240 uncooled ferroelectric detectors is employed, which provides a video stream of the infrared emission in the 7-14 {mu}m wavelength band. A double blackbody is used as reference for absolute temperature calibration. After following a protocol for patient preparation and acclimatization, a basal study is performed. Subsequently, the anatomic region of interest is subjected to a provocation test (a cold stimulus), which induces an autonomic vasoconstriction reflex in normal structures, thus enhancing the thermal contrast due to the differences in the vasculature of the different skin regions. Radiation erythema reactions and melanoma nodules possess typically a faster temperature recovery than healthy, non-irradiated skin. However, some other non-pathological structures are also detectable by infrared imaging, (e.g. scars, vessels, arteriovenous anastomoses and injuries), thus requiring a multi-study comparison in order to discriminate the tumor signal. Besides the superficial nodules, which are readily noticeable by infrared imaging, we have detected thermal signals that are coincident with the location of non-palpable nodules, which are observable by CT and ultrasound. Diffuse regions of fast temperature recovery after a cold stimulus were observed between the third and sixth weeks post-BNCT, concurrent with the clinical manifestation of radiation erythema. The location of the erythematous visible and

  1. Dynamic infrared imaging of cutaneous melanoma and normal skin in patients treated with BNCT

    International Nuclear Information System (INIS)

    Santa Cruz, G.A.; Bertotti, J.; Marin, J.; Gonzalez, S.J.; Gossio, S.; Alvarez, D.; Roth, B.M.C.; Menendez, P.; Pereira, M.D.; Albero, M.; Cubau, L.; Orellano, P.; Liberman, S.J.

    2009-01-01

    We recently initiated a program aimed to investigate the suitability of dynamic infrared imaging for following-up nodular melanoma patients treated with BNCT. The reason that makes infrared imaging attractive is the fact that it constitutes a functional and non-invasive imaging method, providing information on the normal and abnormal physiologic response of the nervous and vascular systems, as well as the local metabolic rate and inflammatory processes that ultimately appear as differences in the skin temperature. An infrared camera, with a focal plane array of 320x240 uncooled ferroelectric detectors is employed, which provides a video stream of the infrared emission in the 7-14 μm wavelength band. A double blackbody is used as reference for absolute temperature calibration. After following a protocol for patient preparation and acclimatization, a basal study is performed. Subsequently, the anatomic region of interest is subjected to a provocation test (a cold stimulus), which induces an autonomic vasoconstriction reflex in normal structures, thus enhancing the thermal contrast due to the differences in the vasculature of the different skin regions. Radiation erythema reactions and melanoma nodules possess typically a faster temperature recovery than healthy, non-irradiated skin. However, some other non-pathological structures are also detectable by infrared imaging, (e.g. scars, vessels, arteriovenous anastomoses and injuries), thus requiring a multi-study comparison in order to discriminate the tumor signal. Besides the superficial nodules, which are readily noticeable by infrared imaging, we have detected thermal signals that are coincident with the location of non-palpable nodules, which are observable by CT and ultrasound. Diffuse regions of fast temperature recovery after a cold stimulus were observed between the third and sixth weeks post-BNCT, concurrent with the clinical manifestation of radiation erythema. The location of the erythematous visible and

  2. Small Business Innovation Research Program. Program solicitation FY 1984

    International Nuclear Information System (INIS)

    1984-01-01

    The Nuclear Regulatory Commission (NRC) invites science-based and high-technology small business firms to submit research proposals under this program solicitation entitled Small Business Innovation Research (SBIR). Firms with strong research capabilities in science or engineering in any of the following topic areas are encouraged to participate. NRC will support high-quality research proposals on important scientific or engineering problems and opportunities that could lead to significant advancement in the safety of nuclear operations or nuclear power plants. Objectives of the solicitation include stimulating technological innovation in the private sector, strengthening the role of small business in meeting Federal research and development needs, increasing the commercial application of NRC-supported research results, and improving the return on investment from Federally funded research for economic and social benefits to the Nation

  3. Space Life Sciences Research and Education Program

    Science.gov (United States)

    Coats, Alfred C.

    2001-01-01

    Since 1969, the Universities Space Research Association (USRA), a private, nonprofit corporation, has worked closely with the National Aeronautics and Space Administration (NASA) to advance space science and technology and to promote education in those areas. USRA's Division of Space Life Sciences (DSLS) has been NASA's life sciences research partner for the past 18 years. For the last six years, our Cooperative Agreement NCC9-41 for the 'Space Life Sciences Research and Education Program' has stimulated and assisted life sciences research and education at NASA's Johnson Space Center (JSC) - both at the Center and in collaboration with outside academic institutions. To accomplish our objectives, the DSLS has facilitated extramural research, developed and managed educational programs, recruited and employed visiting and staff scientists, and managed scientific meetings.

  4. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  5. Spectrum shaping of accelerator-based neutron beams for BNCT

    CERN Document Server

    Montagnini, B; Esposito, J; Giusti, V; Mattioda, F; Varone, R

    2002-01-01

    We describe Monte Carlo simulations of three facilities for the production of epithermal neutrons for Boron Neutron Capture Therapy (BNCT) and examine general aspects and problems of designing the spectrum-shaping assemblies to be used with these neutron sources. The first facility is based on an accelerator-driven low-power subcritical reactor, operating as a neutron amplifier. The other two facilities have no amplifier and rely entirely on their primary sources, a D-T fusion reaction device and a conventional 2.5 MeV proton accelerator with a Li target, respectively.

  6. Maryland controlled fusion research program. Volume I

    International Nuclear Information System (INIS)

    1985-01-01

    This renewal proposal describes the University of Maryland research program on Magnetic Fusion Energy for a three-year period beginning January 1, 1986. This program consists of five tasks: (I) Plasma Theory; (II) Electron Cyclotron Emission Diagnostics for Mirror Machines; (III) Electron Cyclotron Emission Diagnostics on TFTR; (IV) Atomic Physics; and (V) Magnetic Field Measurement by Ion Beams. The four separate tasks of continuing research (Tasks I to IV) and the new experimental task (Task V) are described in detail. The task descriptions contain estimated budgets for CY 86, 87, and 88

  7. Overview of NRC PRA research program

    International Nuclear Information System (INIS)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T.

    1997-01-01

    The NRC's research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements

  8. Environmental Research Program. 1994 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1995-04-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multi-disciplinary and includes fundamental research and development in efficient and environmentally-benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems.

  9. Horonobe underground research program. A program on surveys and researches in fiscal year 2003

    International Nuclear Information System (INIS)

    2003-04-01

    Horonobe underground research program take about 20 years from beginning to finishing of their surveys and researches, and will be carried out at three stages containing 'surveys and researches step (SRS) from on-land (the first step)', 'SRS at excavation (the second step)', and 'SRS at underground facility (the third step)'. This program is contents on surveys and researches to be carried out in fiscal year 2003, the fourth year of the first step. The detail information of the program on Surveys and researches in this fiscal year are described. (G.K.)

  10. Research Program of a Super Fast Reactor

    International Nuclear Information System (INIS)

    Oka, Yoshiaki; Ishiwatari, Yuki; Liu, Jie; Terai, Takayuki; Nagasaki, Shinya; Muroya, Yusa; Abe, Hiroaki; Mori, Hideo; Akiba, Masato; Akimoto, Hajime; Okumura, Keisuke; Akasaka, Naoaki; GOTO, Shoji

    2006-01-01

    Research program of a supercritical-pressure light water cooled fast reactor (Super Fast Reactor) is funded by MEXT (Ministry of Education, Culture, Sports, Science and Technology) in December 2005 as one of the research programs of Japanese NERI (Nuclear Energy Research Initiative). It consists of three programs. (1) development of Super Fast Reactor concept; (2) thermal-hydraulic experiments; (3) material developments. The purpose of the concept development is to pursue the advantage of high power density of fast reactor over thermal reactors to achieve economic competitiveness of fast reactor for its deployment without waiting for exhausting uranium resources. Design goal is not breeding, but maximizing reactor power by using plutonium from spent LWR fuel. MOX will be the fuel of the Super Fast Reactor. Thermal-hydraulic experiments will be conducted with HCFC22 (Hydro chlorofluorocarbons) heat transfer loop of Kyushu University and supercritical water loop at JAEA. Heat transfer data including effect of grid spacers will be taken. The critical flow and condensation of supercritical fluid will be studied. The materials research includes the development and testing of austenitic stainless steel cladding from the experience of PNC1520 for LMFBR. Material for thermal insulation will be tested. SCWR (Supercritical-Water Cooled Reactor) of GIF (Generation-4 International Forum) includes both thermal and fast reactors. The research of the Super Fast Reactor will enhance SCWR research and the data base. The research period will be until March 2010. (authors)

  11. Geothermal Reservoir Technology Research Program: Abstracts of selected research projects

    Energy Technology Data Exchange (ETDEWEB)

    Reed, M.J. (ed.)

    1993-03-01

    Research projects are described in the following areas: geothermal exploration, mapping reservoir properties and reservoir monitoring, and well testing, simulation, and predicting reservoir performance. The objectives, technical approach, and project status of each project are presented. The background, research results, and future plans for each project are discussed. The names, addresses, and telephone and telefax numbers are given for the DOE program manager and the principal investigators. (MHR)

  12. Fatal carotid blowout syndrome after BNCT for head and neck cancers

    International Nuclear Information System (INIS)

    Aihara, T.; Hiratsuka, J.; Ishikawa, H.; Kumada, H.; Ohnishi, K.; Kamitani, N.; Suzuki, M.; Sakurai, H.; Harada, T.

    2015-01-01

    Boron neutron capture therapy (BNCT) is high linear energy transfer (LET) radiation and tumor-selective radiation that does not cause serious damage to the surrounding normal tissues. BNCT might be effective and safe in patients with inoperable, locally advanced head and neck cancers, even those that recur at previously irradiated sites. However, carotid blowout syndrome (CBS) is a lethal complication resulting from malignant invasion of the carotid artery (CA); thus, the risk of CBS should be carefully assessed in patients with risk factors for CBS after BNCT. Thirty-three patients in our institution who underwent BNCT were analyzed. Two patients developed CBS and experienced widespread skin invasion and recurrence close to the carotid artery after irradiation. Careful attention should be paid to the occurrence of CBS if the tumor is located adjacent to the carotid artery. The presence of skin invasion from recurrent lesions after irradiation is an ominous sign of CBS onset and lethal consequences. - Highlights: • This study is fatal carotid blowout syndrome after BNCT for head and neck cancers. • Thirty-three patients in our institution who underwent BNCT were analyzed. • Two patients (2/33) developed CBS. • The presence of skin invasion from recurrent lesions after irradiation is an ominous sign of CBS. • We must be aware of these signs to perform BNCT safely.

  13. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1993-12-01

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  14. Review of Defense Display Research Programs

    Science.gov (United States)

    2001-01-01

    micromirror device (DMD) projection displays, or some future contender, such as organic light emitting diode displays (OLED)—will be installed via...2.3.1 Technology creation successes The crown jewel of the HDS program is the Texas ...Instruments (TI) digital micromirror device (DMD) technology, developed in an $11.3M research effort managed by the Air Force Research Laboratory from 1991

  15. Nuclear gas core propulsion research program

    Science.gov (United States)

    Diaz, Nils J.; Dugan, Edward T.; Anghaie, Samim

    1993-01-01

    Viewgraphs on the nuclear gas core propulsion research program are presented. The objectives of this research are to develop models and experiments, systems, and fuel elements for advanced nuclear thermal propulsion rockets. The fuel elements under investigation are suitable for gas/vapor and multiphase fuel reactors. Topics covered include advanced nuclear propulsion studies, nuclear vapor thermal rocket (NVTR) studies, and ultrahigh temperature nuclear fuels and materials studies.

  16. Jointly Sponsored Research Program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    The Jointly Sponsored Research Program (JSRP) is a US Department of Energy (DOE) program funded through the Office of Fossil Energy and administered at the Morgantown Energy Technology Center. Under this program, which has been in place since Fiscal Year 1990, DOE makes approximately $2.5 million available each year to the Energy and Environmental Research Center (EERC) to fund projects that are of current interest to industry but which still involve significant risk, thus requiring some government contribution to offset the risk if the research is to move forward. The program guidelines require that at least 50% of the project funds originate from nonfederal sources. Projects funded under the JSRP often originate under a complementary base program, which funds higher-risk projects. The projects funded in Fiscal Year 1996 addressed a wide range of Fossil Energy interests, including hot-gas filters for advanced power systems; development of cleaner, more efficient processing technologies; development of environmental control technologies; development of environmental remediation and reuse technologies; development of improved analytical techniques; and development of a beneficiation technique to broaden the use of high-sulfur coal. Descriptions and status for each of the projects funded during the past fiscal year are included in Section A of this document, Statement of Technical Progress.

  17. Program of research - 1990-1991

    International Nuclear Information System (INIS)

    1991-01-01

    The 1990-1991 Program of Research reflects the fundamental changes within the Australian Nuclear Science and Technology Organization (ANSTO) over the past three years as it has oriented itself towards being a more commercially driven organization, an organization responding to market demands and pressures. From July 1, 1990 several key projects have been linked together in the new Industrial Technology Program. The Program encompasses projects that have real potential to earn revenue for ANSTO and make measurable improvements in efficiency and productivity for Australian companies. The Isotope Technology project is researching and transferring to industry radioisotope technology for tracing the effectiveness of plant processes, the movement of materials within blast furnaces and leakages and outages in plant pipework. The two important newcomers are the Quality Technology Centre and the Safety and Reliability group. Details about project leaders, project titles and objectives are provided. ills

  18. ANSTO program of research 1989-1990

    International Nuclear Information System (INIS)

    1989-09-01

    The 1989-1990 Program of Research of the Australian Nuclear Science and Technology Organization identifies the diversity of the organisation's current activities and the role of nuclear science and technology in achieving national goals. Major program areas continue to be biomedicine and health, advanced materials, applications of nuclear physics, environmental science, isotope technology and nuclear technology. Each project in a particular program area is defined in terms of background, objectives recent work and achievements, work planned and resources. External advisory committees which provide advice on research priorities, are viewed as a fundamental part of the ongoing evaluation process of the organization activities in response to changing priorities in industry, government and the community it serves

  19. The northern global change research program

    Science.gov (United States)

    Richard A. Birdsey; John L. Hom; Marla Emery

    1996-01-01

    The Forest Service goal for global change research is to establish a sound scientific basis for making regional, national, and international resource management and policy decisions in the context of global change issues. The objectives of the Northern Global Change Program (NGCP) are to understand: (1) what processes in forest ecosystems are sensitive to physical and...

  20. Successful Attendance Policies and Programs. Research Brief

    Science.gov (United States)

    Education Partnerships, Inc., 2012

    2012-01-01

    What steps can be taken to assure that High School students have the best attendance possible? It is commonly believed and well supported by research that students who attend school regularly are more successful than those who do not. The challenge for high schools is to design and implement attendance policies and programs that monitor,…

  1. Research Award: Supporting Inclusive Growth program Deadline ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    HEAD OFFICE / SIÈGE : 150 Kent Street / 150, rue Kent PO Box / CP 8500 Ottawa ON Canada K1G 3H9. Phone / Tél. : +1 613 236 6163 Email / Courriel : info@idrc.ca / info@crdi.ca. Research Award: Supporting Inclusive Growth program. Deadline: 12 September 2012. Please note that all applications must be sent ...

  2. Pilot Project - National Development Research Program (Honduras ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The idea for a National Research and Training Program (PRIDE, in Spanish) emerged from the IDRC-supported project, "100133 Building Learning Systems for Honduran Development." This grant will support a pilot version of PRIDE consisting of two calls for proposals. The first will focus on poverty and development ...

  3. Crime Laboratory Proficiency Testing Research Program.

    Science.gov (United States)

    Peterson, Joseph L.; And Others

    A three-year research effort was conducted to design a crime laboratory proficiency testing program encompassing the United States. The objectives were to: (1) determine the feasibility of preparation and distribution of different classes of physical evidence; (2) assess the accuracy of criminalistics laboratories in the processing of selected…

  4. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  5. Mendelian Genetics: Paradigm, Conjecture, or Research Program.

    Science.gov (United States)

    Oldham, V.; Brouwer, W.

    1984-01-01

    Applies Kuhn's model of the structure of scientific revolutions, Popper's hypothetic-deductive model of science, and Lakatos' methodology of competing research programs to a historical biological episode. Suggests using Kuhn's model (emphasizing the nonrational basis of science) and Popper's model (emphasizing the rational basis of science) in…

  6. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    1991-06-01

    A comprehensive Nuclear Plant Aging Research (NPAR) Program was implemented by the US NRC office of Nuclear Regulatory Research in 1985 to identify and resolve technical safety issues related to the aging of systems, structures, and components in operating nuclear power plants. This is Revision 2 to the Nuclear Plant Aging Research Program Plant. This planes defines the goals of the program the current status of research, and summarizes utilization of the research results in the regulatory process. The plan also describes major milestones and schedules for coordinating research within the agency and with organizations and institutions outside the agency, both domestic and foreign. Currently the NPAR Program comprises seven major areas: (1) hardware-oriented engineering research involving components and structures; (2) system-oriented aging interaction studies; (3) development of technical bases for license renewal rulemaking; (4) determining risk significance of aging phenomena; (5) development of technical bases for resolving generic safety issues; (6) recommendations for field inspection and maintenance addressing aging concerns; (7) and residual lifetime evaluations of major LWR components and structures. The NPAR technical database comprises approximately 100 NUREG/CR reports by June 1991, plus numerous published papers and proceedings that offer regulators and industry important insights to aging characteristics and aging management of safety-related equipment. Regulatory applications include revisions to and development of regulatory guides and technical specifications; support to resolve generic safety issues; development of codes and standards; evaluation of diagnostic techniques; (e.g., for cables and valves); and technical support for development of the license renewal rule. 80 refs., 25 figs., 10 tabs

  7. A research program in empirical computer science

    Science.gov (United States)

    Knight, J. C.

    1991-01-01

    During the grant reporting period our primary activities have been to begin preparation for the establishment of a research program in experimental computer science. The focus of research in this program will be safety-critical systems. Many questions that arise in the effort to improve software dependability can only be addressed empirically. For example, there is no way to predict the performance of the various proposed approaches to building fault-tolerant software. Performance models, though valuable, are parameterized and cannot be used to make quantitative predictions without experimental determination of underlying distributions. In the past, experimentation has been able to shed some light on the practical benefits and limitations of software fault tolerance. It is common, also, for experimentation to reveal new questions or new aspects of problems that were previously unknown. A good example is the Consistent Comparison Problem that was revealed by experimentation and subsequently studied in depth. The result was a clear understanding of a previously unknown problem with software fault tolerance. The purpose of a research program in empirical computer science is to perform controlled experiments in the area of real-time, embedded control systems. The goal of the various experiments will be to determine better approaches to the construction of the software for computing systems that have to be relied upon. As such it will validate research concepts from other sources, provide new research results, and facilitate the transition of research results from concepts to practical procedures that can be applied with low risk to NASA flight projects. The target of experimentation will be the production software development activities undertaken by any organization prepared to contribute to the research program. Experimental goals, procedures, data analysis and result reporting will be performed for the most part by the University of Virginia.

  8. Federal Geothermal Research Program Update, FY 2000

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Joel Lawrence

    2001-08-01

    The Department of Energy's Geothermal Program serves two broad purposes: 1) to assist industry in overcoming near-term barriers by conducting cost-shared research and field verification that allows geothermal energy to compete in today's aggressive energy markets; and 2) to undertake fundamental research with potentially large economic payoffs. The four categories of work used to distinguish the research activities of the Geothermal Program during FY 2000 reflect the main components of real-world geothermal projects. These categories form the main sections of the project descriptions in this Research Update. Exploration Technology research focuses on developing instruments and techniques to discover hidden hydrothermal systems and to explore the deep portions of known systems. Research in geophysical and geochemical methods is expected to yield increased knowledge of hidden geothermal systems. Reservoir Technology research combines laboratory and analytical investigations with equipment development and field testing to establish practical tools for resource development and management for both hydrothermal reservoirs and enhanced geothermal systems. Research in various reservoir analysis techniques is generating a wide range of information that facilitates development of improved reservoir management tools. Drilling Technology focuses on developing improved, economic drilling and completion technology for geothermal wells. Ongoing research to avert lost circulation episodes in geothermal drilling is yielding positive results. Conversion Technology research focuses on reducing costs and improving binary conversion cycle efficiency, to permit greater use of the more abundant moderate-temperature geothermal resource, and on the development of materials that will improve the operating characteristics of many types of geothermal energy equipment. Increased output and improved performance of binary cycles will result from investigations in heat cycle research.

  9. DOE (Department of Energy) Epidemiologic Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal.

  10. Human Research Program Requirements Document (Revision C)

    Science.gov (United States)

    Vargas, Paul R.

    2009-01-01

    The purpose of this document is to define, document, and allocate the Human Research Program (HRP) requirements to the HRP Program Elements. It establishes the flow-down of requirements from Exploration Systems Mission Directorate (ESMD) and Office of the Chief Health and Medical Officer (OCHMO) to the various Program Elements of the HRP to ensure that human research and technology countermeasure investments are made to insure the delivery of countermeasures and technologies that satisfy ESMD's and OCHMO's exploration mission requirements. Requirements driving the HRP work and deliverables are derived from the exploration architecture, as well as Agency standards regarding the maintenance of human health and performance. Agency human health and performance standards will define acceptable risk for each type and duration of exploration mission. It is critical to have the best available scientific and clinical evidence in setting and validating these standards. In addition, it is imperative that the best available evidence on preventing and mitigating human health and performance risks is incorporated into exploration mission and vehicle designs. These elements form the basis of the HRP research and technology development requirements and highlight the importance of HRP investments in enabling NASA's exploration missions. This PRD defines the requirements of the HRP which is comprised of the following major Program Elements: Behavioral Health and Performance (BHP), Exploration Medical Capability (ExMC), Human Health Countermeasures (HHC), ISS Medical Project (ISSMP), Space Human Factors and Habitability (SHFH), and Space Radiation (SR).

  11. DOE [Department of Energy] Epidemiologic Research Program

    International Nuclear Information System (INIS)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal

  12. Small business innovation research: Program solicitation

    Science.gov (United States)

    1989-01-01

    This, the seventh annual SBIR solicitation by NASA, describes the program, identifies eligibility requirements, outlines the required proposal format and content, states proposal preparation and submission requirements, describes the proposal evaluation and award selection process, and provides other information to assist those interested in participating in NASA's SBIR program. It also identifies the Technical Topics and Subtopics in which SBIR Phase 1 proposals are solicited in 1989. These Topics and Subtopics cover a broad range of current NASA interests, but do not necessarily include all areas in which NASA plans or currently conducts research. High-risk high pay-off innovations are desired.

  13. Gene transfer-applied BNCT (g-BNCT) for amelanotic melanoma in brain. Further upregulation of {sup 10}B uptake by cell modulation

    Energy Technology Data Exchange (ETDEWEB)

    Iwakura, M.; Tamaki, N. [Kobe Univ. (Japan). School of Medicine; Kondoh, H.; Mishima, Y. [Mishima Inst. for Dermatol. Res., Kobe, Hyogo (Japan); Hiratsuka, J. [Kawasaki Medical School, Dept. Radiation Oncol., Kurashiki, Okayama (Japan)

    2000-10-01

    Our success in eradicating melanoma by single BNCT with BPA led to the next urgent theme, i.e. application of such BNCT for currently uncurable melanoma metastasis in brain. In order to establish {sup 10}B-BPA-BNCT for melanoma in brain, we have investigated the pharmacokinetics of BPA which is most critical factor for successful BNCT, in melanotic and amelanotic and further tyrosinase gene-transfected amelanotic melanoma proliferating in brain having blood-brain-barrier, as compared to melanoma proliferating in skin. We have established three implanted models for melanoma in brain: 1) A1059 cells, amelanotic melanoma, 2) B16B15b cells, melanotic melanoma cells, highly metastatic to brain, and 3) TA1059 cells, with active melanogenesis induced by tyrosinase gene transfection. We would like to report the results of comparative analysis of the BPA uptake ability in these melanoma cells in both brain and skin. Based on these findings, we are further investigating to enhance {sup 10}B-BPA uptake by not only g-BNCT but also by additional melanogenesis upregulating cell modulation. (author)

  14. Gene transfer-applied BNCT (g-BNCT) for amelanotic melanoma in brain. Further upregulation of 10B uptake by cell modulation

    International Nuclear Information System (INIS)

    Iwakura, M.; Tamaki, N.; Hiratsuka, J.

    2000-01-01

    Our success in eradicating melanoma by single BNCT with BPA led to the next urgent theme, i.e. application of such BNCT for currently uncurable melanoma metastasis in brain. In order to establish 10 B-BPA-BNCT for melanoma in brain, we have investigated the pharmacokinetics of BPA which is most critical factor for successful BNCT, in melanotic and amelanotic and further tyrosinase gene-transfected amelanotic melanoma proliferating in brain having blood-brain-barrier, as compared to melanoma proliferating in skin. We have established three implanted models for melanoma in brain: 1) A1059 cells, amelanotic melanoma, 2) B16B15b cells, melanotic melanoma cells, highly metastatic to brain, and 3) TA1059 cells, with active melanogenesis induced by tyrosinase gene transfection. We would like to report the results of comparative analysis of the BPA uptake ability in these melanoma cells in both brain and skin. Based on these findings, we are further investigating to enhance 10 B-BPA uptake by not only g-BNCT but also by additional melanogenesis upregulating cell modulation. (author)

  15. Suborbital Science Program: Dryden Flight Research Center

    Science.gov (United States)

    DelFrate, John

    2008-01-01

    This viewgraph presentation reviews the suborbital science program at NASA Dryden Flight Research Center. The Program Objectives are given in various areas: (1) Satellite Calibration and Validation (Cal/val)--Provide methods to perform the cal/val requirements for Earth Observing System satellites; (2) New Sensor Development -- Provide methods to reduce risk for new sensor concepts and algorithm development prior to committing sensors to operations; (3) Process Studies -- Facilitate the acquisition of high spatial/temporal resolution focused measurements that are required to understand small atmospheric and surface structures which generate powerful Earth system effects; and (4) Airborne Networking -- Develop disruption-tolerant networking to enable integrated multiple scale measurements of critical environmental features. Dryden supports the NASA Airborne Science Program and the nation in several elements: ER-2, G-3, DC-8, Ikhana (Predator B) & Global Hawk and Reveal. These are reviewed in detail in the presentation.

  16. The National Geothermal Energy Research Program

    Science.gov (United States)

    Green, R. J.

    1974-01-01

    The continuous demand for energy and the concern for shortages of conventional energy resources have spurred the nation to consider alternate energy resources, such as geothermal. Although significant growth in the one natural steam field located in the United States has occurred, a major effort is now needed if geothermal energy, in its several forms, is to contribute to the nation's energy supplies. From the early informal efforts of an Interagency Panel for Geothermal Energy Research, a 5-year Federal program has evolved whose objective is the rapid development of a commercial industry for the utilization of geothermal resources for electric power production and other products. The Federal program seeks to evaluate the realistic potential of geothermal energy, to support the necessary research and technology needed to demonstrate the economic and environmental feasibility of the several types of geothermal resources, and to address the legal and institutional problems concerned in the stimulation and regulation of this new industry.

  17. Program for transfer research and impact studies

    Science.gov (United States)

    Rusnak, J. J.; Freeman, J. E.; Hartley, J. M.; Kottenstette, J. P.; Staskin, E. R.

    1973-01-01

    Research activities conducted under the Program for Transfer Research and Impact Studies (TRIS) during 1972 included: (1) preparation of 10,196 TSP requests for TRIS application analysis; (2) interviews with over 500 individuals concerning the technical, economic, and social impacts of NASA-generated technology; (3) preparation of 38 new technology transfer example files and 101 new transfer cases; and (4) maintenance of a technology transfer library containing more than 2,900 titles. Six different modes of technology utilization are used to illustrate the pervasiveness of the transfer and diffusion of aerospace innovations. These modes also provide a basis for distinguishing the unique characteristics of the NASA Technology Utilization Program. An examination is reported of the ways in which NASA-generated technology is contributing to beneficial social change in five major areas of human concern: health, environment, safety, transportation, and communication.

  18. The research program at SIS/ESR

    International Nuclear Information System (INIS)

    Henning, W.

    1989-04-01

    A varied research program is currently in preparation for the expanded facility. Above one hundred experiments have been proposed following a call for proposals about 1 1/2 year ago, and have been reviewed by an international science committee. About half of the proposals were aimed at research in nuclear and nuclear-matter physics. These are discussed in more detail in the present overview. In addition, about 25% of the proposals were in the area of atomic physics, planning to make use of the capability of the new facility to strip even the heaviest ions into the innermost shells, with the additional possibility of subsequent cooling and deceleration. Biological research, utilizing the larger range of ions at elevated energies and thus deeper penetration and also irradiation in atmosphere, represented about 15% of the proposals; the rest was divided among various projects of applied research. (orig./HSI)

  19. Investigation of development and management of treatment planning systems for BNCT at foreign facilities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    A new computational dosimetry system for BNCT: JCDS is developed by JAERI in order to carry out BNCT with epithermal neutron beam at present. The development and management situation of computational dosimetry system, which are developed and are used in BNCT facilities in foreign countries, were investigated in order to accurately grasp functions necessary for preparation of the treatment planning and its future subjects. In present state, 'SERA', which are developed by Idaho National Engineering and Environmental Laboratory (INEEL), is used in many BNCT facilities. Followings are necessary for development and management of the treatment planning system. (1) Reliability confirmation of system performance by verification as comparison examination of calculated value with actual experimental measured value. (2) Confirmation systems such as periodic maintenance for retention of the system quality. (3) The improvement system, which always considered relative merits and demerits with other computational dosimetry system. (4) The development of integrated system with patient setting. (author)

  20. The Nanotoxicology Research Program in NIOSH

    International Nuclear Information System (INIS)

    Castranova, Vincent

    2009-01-01

    The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects.

  1. An Android Research and Development Program.

    Science.gov (United States)

    1983-03-01

    areas discussed were robot arms, robot hands, and robot locomotion systems, without reference to a specific model. He summarized the control issues...school to do this. AFAMRL. The Air Force Aerospace Medical Research Laboratory and its Modeling and Analysis Branch had a program in areas of bionics ...Manipulators. He worked most of 1979 for Unimation prior to coming on active duty (Air Force). McGhee, R. B. "Robot Locomotion with Active Terrain

  2. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    1994-02-01

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory's core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology

  3. A Research Program in Computer Technology

    Science.gov (United States)

    1976-07-01

    OVERI_ AeSSRA -1 ’ Continuo on reverse side It necessary anod Identify by block number, This report summarizes the research performed under Contract OAIIC...programs. Important progress has been made in the following areas: improved user environment and interface to the verifier, extensible verification...the facilities at ISI The Institute provides 24-hour availability of TENEX systems, maintenance, and operators, continued development/ improvement

  4. Sandia combustion research program: Annual report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, R.E.; Sanders, B.R.; Ivanetich, C.A. (eds.)

    1988-01-01

    More than a decade ago, in response to a national energy crisis, Sandia proposed to the US Department of Energy a new, ambitious program in combustion research. Our strategy was to apply the rapidly increasing capabilities in lasers and computers to combustion science and technology. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''User Facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative--involving US universities, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions of several research projects which have been stimulated by Working Groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship Program has been instrumental in the success of some of the joint efforts. The remainder of this report presents research results of calendar year 1987, separated thematically into nine categories. Refereed journal articles appearing in print during 1987, along with selected other publications, are included at the end of Section 10. In addition to our ''traditional'' research--chemistry, reacting flow, diagnostics, engine combustion, and coal combustion--you will note continued progress in somewhat recent themes: pulse combustion, high temperature materials, and energetic materials, for example. Moreover, we have just started a small, new effort to understand combustion-related issues in the management of toxic and hazardous materials.

  5. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  6. Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT).

    Science.gov (United States)

    Seki, Ryoichi; Wakisaka, Yushi; Morimoto, Nami; Takashina, Masaaki; Koizumi, Masahiko; Toki, Hiroshi; Fukuda, Mitsuhiro

    2017-12-01

    The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept at an introductory level in the discussion in this tutorial review.

  7. Long-survivors of glioblatoma treated with boron neutron capture therapy (BNCT)

    International Nuclear Information System (INIS)

    Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, H.

    2011-01-01

    The purpose of this study was to compare the radiation dose between long-survivors and non-long-survivors in patients with glioblatoma (GBM) treated with boron neutron capture therapy (BNCT). Among 23 GBM patients treated with BNCT, there were five patients who survived more than three years after diagnosis. The physical and weighted dose of the minimum gross tumor volume (GTV) of long-survivors was much higher than that of non-long survivors with significant statistical differences.

  8. Summer High School Apprenticeship Research Program (SHARP)

    Science.gov (United States)

    1997-01-01

    objectives were consistent with the overall program goals. Modem Technology Systems, Inc., was able to meet the SHARP Apprentices, Coordinators and Mentors during their site visits to Stennis Space Center, Ames Research Center and Dryden Flight Research Center. All three Centers had very efficient programs and adhered to SHARP's general guidelines and procedures. MTSI was able to meet the apprentices from the other Centers via satellite in July during the SHARP Video-Teleconference(ViTS). The ViTS offered the apprentices and the NASA and SHARP Coordinators the opportunity to introduce themselves. The apprentices from each Center presented topical "Cutting Edge Projects". Some of the accomplishments for the 1997 SHARP Program year included: MTSI hiring apprentices from four of the nine NASA Centers, the full utilization of the EDCATS by apprentices and NASA/SHARP Coordinators, the distribution of the SHARP Apprentice College and Scholarship Directory, a reunion with former apprentices from Langley Research Center and the development of a SHARP Recruitment Poster. MTSI developed another exciting newsletter containing graphics and articles submitted by the apprentices and the SHARP Management Team.

  9. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  10. Research program of the Neutrino Research Group. Year 2004

    International Nuclear Information System (INIS)

    2004-01-01

    For the last two decades, neutrino physics has been producing major discoveries including neutrino oscillations. These results gave clear confirmation that active neutrinos oscillate and therefore have mass with three different mass states. This is a very important result showing that the Minimal Standard Model is incomplete and requires an extension which is not yet known. The neutrino research field is very broad and active, at the frontier of today's particle physics. The creation of a Neutrino Research Group (GDR) was proposed in 2004 with the aim of gathering CEA and CNRS research teams working on Neutrino Physics on experimental or theoretical level. This document presents the Research program of the Neutrino Research Group which is divided into 5 working groups with the following activities: 1 - Determination of neutrino parameters; 2 - Physics beyond the standard model; 3 - Neutrinos in the universe; 4 - Accelerators, detection means, R and D and valorisation; 5 - Common tools to all working groups. The research group participating laboratories and teams are listed at the end of the document

  11. Ocean Margins Programs, Phase I research summaries

    Energy Technology Data Exchange (ETDEWEB)

    Verity, P. [ed.

    1994-08-01

    During FY 1992, the DOE restructured its regional coastal-ocean programs into a new Ocean Margins Program (OMP), to: Quantify the ecological and biogeochemical processes and mechanisms that affect the cycling, flux, and storage of carbon and other biogenic elements at the land/ocean interface; Define ocean-margin sources and sinks in global biogeochemical cycles, and; Determine whether continental shelves are quantitatively significant in removing carbon dioxide from the atmosphere and isolating it via burial in sediments or export to the interior ocean. Currently, the DOE Ocean Margins Program supports more than 70 principal and co-principal investigators, spanning more than 30 academic institutions. Research funded by the OMP amounted to about $6.9M in FY 1994. This document is a collection of abstracts summarizing the component projects of Phase I of the OMP. This phase included both research and technology development, and comprised projects of both two and three years duration. The attached abstracts describe the goals, methods, measurement scales, strengths and limitations, and status of each project, and level of support. Keywords are provided to index the various projects. The names, addresses, affiliations, and major areas of expertise of the investigators are provided in appendices.

  12. Stability of high-speed lithium sheet jets for the neutron source in Boron Neutron Capture Therapy (BNCT)

    International Nuclear Information System (INIS)

    Nakagawa, Masamichi; Takahashi, Minoru; Aritomi, Masanori; Kobayashi, Toru

    2014-01-01

    The stability of high-speed liquid lithium sheet jets was analytically studied for the neutron source in Boron Neutron Capture Therapy (BNCT), which makes cancers and tumors curable with cell-level selections and hence high QOL. The object of our research is to realize the thin and high-speed plane sheet jets of liquid lithium in a high-vacuum as an accelerator target. Linear analysis approach is made to the stability on thin plane sheet jets of liquid lithium in a high-vacuum, and then our analytical results were compared with the previous experimental ones. We proved that the waves of surface tension on thin lithium sheet jets in a high-vacuum are of supercritical flows and neutral stable under about 17.4 m/s in flow velocity and that the fast non-dispersive anti-symmetric waves are more significant than the very slow dispersive symmetric waves. We also formulated the equation of shrinking angle in isosceles-triangularly or isosceles-trapezoidal shrinking sheet jets corresponding to the Mach angle of supersonic gas flows. This formula states universally the physical meaning of Weber number of sheet jets on the wave of surface tension in supercritical flows. We obtained satisfactory prospects (making choice of larger flow velocity U and larger thickness of sheet a) to materialize a liquid target of accelerator in BNCT. (author)

  13. TIDBIT - the INEL database of BNCT information and treatment

    International Nuclear Information System (INIS)

    Mancuso, C.A.

    1995-01-01

    The INEL Database of BNCT Information and Treatment (TIDBIT) has been under development for several years. Late in 1993, a new software development team took over the project and did and assessment of the current implementation status, and determined that the user interface was unsatisfactory for the expected users and that the data structures were out of step with the current state of reality. The team evaluated several tools that would improve the user interface to make the system easier to use. Uniface turned out to be the product of choice. During 1994, TIDBIT got its name, underwent a complete change of appearance, had a major overhaul to the data structures that support the application, and system documentation was begun. A prototype of the system was demonstrated in September 1994

  14. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  15. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  16. Environmental research program. 1995 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1996-06-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multidisciplinary and includes fundamental research and development in efficient and environmentally benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and noncriteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems. Combustion chemistry research emphasizes modeling at microscopic and macroscopic scales. At the microscopic scale, functional sensitivity analysis is used to explore the nature of the potential-to-dynamics relationships for reacting systems. Rate coefficients are estimated using quantum dynamics and path integral approaches. At the macroscopic level, combustion processes are modelled using chemical mechanisms at the appropriate level of detail dictated by the requirements of predicting particular aspects of combustion behavior. Parallel computing has facilitated the efforts to use detailed chemistry in models of turbulent reacting flow to predict minor species concentrations.

  17. Mixtures Research at NIEHS: An Evolving Program

    Science.gov (United States)

    Rider, Cynthia V; Carlin, Danielle J; DeVito, Micheal J; Thompson, Claudia L; Walker, Nigel J

    2014-01-01

    The National Institute of Environmental Health Sciences (NIEHS) has a rich history in evaluating the toxicity of mixtures. The types of mixtures assessed by the Division of the National Toxicology Program (DNTP) and the extramural community (through the Division of Extramural Research and Training (DERT)) have included a broad range of chemicals and toxicants, with each study having a unique set of questions and design considerations. Some examples of the types of mixtures studied include: groundwater contaminants, pesticides/fertilizers, dioxin-like chemicals (assessing the toxic equivalency approach), drug combinations, air pollution, metals, polycyclic aromatic hydrocarbons, technical mixtures (e.g. pentachlorophenol, flame retardants), and mixed entities (e.g. herbals, asbestos). These endeavors have provided excellent data on the toxicity of specific mixtures and have been informative to the human health risk assessment process in general (e.g. providing data on low dose exposures to environmental chemicals). However, the mixtures research effort at NIEHS, to date, has been driven by test article nominations to the DNTP or by investigator-initiated research through DERT. Recently, the NIEHS has embarked upon an effort to coordinate mixtures research across both intramural and extramural divisions in order to maximize mixtures research results. A path forward for NIEHS mixtures research will be based on feedback from a Request for Information (RFI) designed to gather up-to-date views on the knowledge gaps and roadblocks to evaluating mixtures and performing cumulative risk assessment, and a workshop organized to bring together mixtures experts from risk assessment, exposure science, biology, epidemiology, and statistics. The future of mixtures research at NIEHS will include projects from nominations to DNTP, studies by extramural investigators, and collaborations across government agencies that address high-priority questions in the field of mixtures research

  18. A Community - Centered Astronomy Research Program

    Science.gov (United States)

    Boyce, Pat; Boyce, Grady

    2017-06-01

    The Boyce Research Initiatives and Education Foundation (BRIEF) is providing semester-long, hands-on, astronomy research experiences for students of all ages that results in their publishing peer-reviewed papers. The course in astronomy and double star research has evolved from a face-to-face learning experience with two instructors to an online - hybrid course that simultaneously supports classroom instruction at a variety of schools in the San Diego area. Currently, there are over 65 students enrolled in three community colleges, seven high schools, and one university as well as individual adult learners. Instructional experience, courseware, and supporting systems were developed and refined through experience gained in classroom settings from 2014 through 2016. Topics of instruction include Kepler's Laws, basic astrometry, properties of light, CCD imaging, use of filters for varying stellar spectral types, and how to perform research, scientific writing, and proposal preparation. Volunteer instructors were trained by taking the course and producing their own research papers. An expanded program was launched in the fall semester of 2016. Twelve papers from seven schools were produced; eight have been accepted for publication by the Journal of Double Observations (JDSO) and the remainder are in peer review. Three additional papers have been accepted by the JDSO and two more are in process papers. Three college professors and five advanced amateur astronomers are now qualified volunteer instructors. Supporting tools are provided by a BRIEF server and other online services. The server-based tools range from Microsoft Office and planetarium software to top-notch imaging programs and computational software for data reduction for each student team. Observations are performed by robotic telescopes worldwide supported by BRIEF. With this success, student demand has increased significantly. Many of the graduates of the first semester course wanted to expand their

  19. Gas Hydrates Research Programs: An International Review

    Energy Technology Data Exchange (ETDEWEB)

    Jorge Gabitto; Maria Barrufet

    2009-12-09

    Gas hydrates sediments have the potential of providing a huge amount of natural gas for human use. Hydrate sediments have been found in many different regions where the required temperature and pressure conditions have been satisfied. Resource exploitation is related to the safe dissociation of the gas hydrate sediments. Basic depressurization techniques and thermal stimulation processes have been tried in pilot efforts to exploit the resource. There is a growing interest in gas hydrates all over the world due to the inevitable decline of oil and gas reserves. Many different countries are interested in this valuable resource. Unsurprisingly, developed countries with limited energy resources have taken the lead in worldwide gas hydrates research and exploration. The goal of this research project is to collect information in order to record and evaluate the relative strengths and goals of the different gas hydrates programs throughout the world. A thorough literature search about gas hydrates research activities has been conducted. The main participants in the research effort have been identified and summaries of their past and present activities reported. An evaluation section discussing present and future research activities has also been included.

  20. 77 FR 46805 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2012-08-06

    ... Small Business Innovation Research Program Policy Directive; Small Business Technology Transfer Program Policy Directive; Small Business Innovation Research (SBIR) Program and Small Business Technology... ADMINISTRATION 13 CFR Chapter I RIN 3245-AF84 Small Business Innovation Research Program Policy Directive AGENCY...

  1. Tribal Ecosystem Research Program (TERP) Workshop ...

    Science.gov (United States)

    USEPA is developing alternative approaches to quantify improvements to impaired waterbodies (USEPA 303(d)/TMDL Draft Guidance). Tribal environmental programs are leading the way in the paradigm shift towards sustainability of natural resources. Resources such as wildlife, aquatic habitat are dependent on the development of a riparian and upland management strategy, which considers and adapts to certain ecological relationships. Tribal traditional environmental knowledge (TEK) is a central concept in the cultural and resource stewardship practices of Native Americans. Native American populations have been accumulating knowledge of these ecosystem relationships, and have relied on them for basic survival for thousands of years. As such, TEK is the accumulated understanding of ecosystem function. As North America’s first environmental stewards, Native American populations have developed a unique relationship with the land and its resources. Objective of this workshop is to fuse TEK with environmental science to create an ecosystem, or landscape, research program oriented toward land management practices. This is essentially translating and combining TEK with an ecosystem function approach to provide a comprehensive basis for identifying and evaluating current and historical land use practices. Tribal and USEPA cooperative stream and wetland research focuses on making the connections between upland and riparian ecosystems. Analyzing spatial relationships and short

  2. Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases in BDIX rats

    International Nuclear Information System (INIS)

    Trivillin, V.A.; Garabalino, M.A.; Colombo, L.L.

    2013-01-01

    Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases in BDIX rats Introduction: Boron Neutron Capture Therapy (BNCT) is based on selective tumor uptake of boron compounds, followed by neutron irradiation. BNCT was proposed for the treatment of unresectable, diffuse lung metastases. The aim of the present study was to perform BNCT studies in an experimental model of lung metastases. Materials and Methods: 3 x 106/0.5 ml colon carcinoma cells (DHD/K12/TRb) were injected iv in syngeneic BDIX rats. Three weeks post-inoculation, rats with diffuse lung metastases were used for in vivo BNCT studies in the RA-3 Nuclear Reactor. Based on previous biodistribution studies and computational dosimetry with Monte Carlo simulation, 2 doses were prescribed, i.e. 4 Gy and 8 Gy minimum absorbed dose to tumor. The animals were assigned to 5 experimental groups (n= 4 to 8) at each dose level: T0 (euthanized pre-treatment), BPA-BNCT, Comb-BNCT (BPA+GB-10), Beam only (background dose) and Sham (same manipulation, no treatment). Boron concentration was measured in a blood sample taken pre-irradiation to verify that the value was in the range established in previous biodistribution studies. The animals were followed clinically for 2 weeks after neutron irradiation and then euthanized to assess the response of tumor and normal lung, macroscopically and histologically. To date we have evaluated the end-point weight of lung (normal lung + metastases) and % lung weight/body weight as an indicator of tumor growth. Results: The statistical analysis (ANOVA) of % lung weight/body weight showed statistically significant differences (p<0.05) between groups T0 (0.79 ± 0.38) and Sham (1.87 ± 0.91). No statistically significant differences were observed between the Beam only groups (at both dose levels) and Sham. Similar and statistically significant tumor control was induced in the groups BPA-BNCT Low dose (LD) (0.56 ± 0.11), BPA-BNCT High dose (HD) (0.80 ± 0.16), Comb-BNCT

  3. National Research Council Research Associateships Program with Methane Hydrates Fellowships Program/National Energy Technology Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Basques, Eric O. [National Academy of Sciences, Washington, DC (United States)

    2014-03-20

    This report summarizes work carried out over the period from July 5, 2005-January 31, 2014. The work was carried out by the National Research Council Research Associateships Program of the National Academies, under the US Department of Energy's National Energy Technology Laboratory (NETL) program. This Technical Report consists of a description of activity from 2005 through 2014, broken out within yearly timeframes, for NRC/NETL Associateships researchers at NETL laboratories which includes individual tenure reports from Associates over this time period. The report also includes individual tenure reports from associates over this time period. The report also includes descriptions of program promotion efforts, a breakdown of the review competitions, awards offered, and Associate's activities during their tenure.

  4. First clinical results on the finnish study on BPA-mediated BNCT in glioblastoma

    International Nuclear Information System (INIS)

    Kankaanranta, L.; Seppaelae, T.; Kallio, M.

    2000-01-01

    An open phase I dose-escalation boron neutron capture therapy (BNCT) study on glioblastoma multiforme (GBM) was initiated at the BNCT facility FiR 1, Espoo, Finland, in May 1999. The aim of the study is to investigate the safety of boronophenylalanine (BPA)-mediated BNCT. Ten GBM patients were treated with a 2-field treatment plan using one fraction. BPA-F was used as the 10 B carrier infused as a fructose solution 290 mg BPA/kg over 2-hours prior to irradiation with epithermal neutrons. Average doses to the normal brain, contrast enhancing tumour, and the target ranged from 3.0 to 5.6 Gy (W), from 35.1 to 66.7 Gy (W), and from 29.6 to 53.6 Gy (W), respectively. BNCT was associated with acceptable toxicity. The median follow-up is 9 months (range, 3 to 16 months) post diagnosis in July 2000. Seven of the 10 patients have recurrent or persistent GBM, and the median time to progression is 8 months. Only one patient has died, and the estimated 1-year overall survival is 86%. Five of the recurrent tumours were treated with external beam photon radiation therapy to the total dose of 30-40 Gy with few acute side-effects. These preliminary findings suggest that acute toxicity of BPA-mediated BNCT is acceptable when average brain doses of 5.6 Gy (W) or less are used. The followup time is too short to evaluate survival, but the estimated 1-year survival of 86% achieved with BNCT followed by conventional photon irradiation at the time of tumour progression is encouraging and emphasises the need of further investigation of BPA-mediated BNCT. (author)

  5. Program Assistant | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Under the direction of the Program Leader, the Program Assistant provides operational and administrative assistance to the Program Leader and Program Staff, performs a variety of administrative, coordination and logistical services in support of the operations of the Program, and assists with information management the ...

  6. DOE-EERC jointly sponsored research program

    Energy Technology Data Exchange (ETDEWEB)

    Hendrikson, J.G.; Sondreal, E.A.

    1999-09-01

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC21-93MC30098 funded through the Office of Fossil Energy and administered at the Federal Energy Technology Center (FETC) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy and Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying efficient, nonpolluting energy technologies that can compete effectively in meeting market demands for clean fuels, chemical feedstocks, and electricity in the 21st century. The objective of the JSRP was to advance the deployment of advanced technologies for improving energy efficiency and environmental performance through jointly sponsored research on topics that would not be adequately addressed by the private sector alone. Examples of such topics include the barriers to hot-gas cleaning impeding the deployment of high-efficiency power systems and the search for practical means for sequestering CO{sub 2} generated by fossil fuel combustion. The selection of particular research projects was guided by a combination of DOE priorities and market needs, as provided by the requirement for joint venture funding approved both by DOE and the private sector sponsor. The research addressed many different energy resource and related environmental problems, with emphasis directed toward the EERC's historic lead mission in low-rank coals (LRCs), which represent approximately half of the U.S. coal resources in the conterminous states, much larger potential resources in Alaska, and a major part of the energy base in the former U.S.S.R., East Central Europe, and the Pacific Rim. The Base and JSRP agreements were tailored to the growing awareness of critical environmental issues, including water supply and quality, air toxics (e.g., mercury), fine respirable particulate matter (PM{sub 2.5}), and the goal of zero net CO{sub 2} emissions.

  7. Severe Accident Research Program plan update

    International Nuclear Information System (INIS)

    1992-12-01

    In August 1989, the staff published NUREG-1365, ''Revised Severe Accident Research Program Plan.'' Since 1989, significant progress has been made in severe accident research to warrant an update to NUREG-1365. The staff has prepared this SARP Plan Update to: (1) Identify those issues that have been closed or are near completion, (2) Describe the progress in our understanding of important severe accident phenomena, (3) Define the long-term research that is directed at improving our understanding of severe accident phenomena and developing improved methods for assessing core melt progression, direct containment heating, and fuel-coolant interactions, and (4) Reflect the growing emphasis in two additional areas--advanced light water reactors, and support for the assessment of criteria for containment performance during severe accidents. The report describes recent major accomplishments in understanding the underlying phenomena that can occur during a severe accident. These include Mark I liner failure, severe accident scaling methodology, source term issues, core-concrete interactions, hydrogen transport and combustion, TMI-2 Vessel Investigation Project, and direct containment heating. The report also describes the major planned activities under the SARP over the next several years. These activities will focus on two phenomenological issues (core melt progression, and fuel-coolant interactions and debris coolability) that have significant uncertainties that impact our understanding and ability to predict severe accident phenomena and their effect on containment performance SARP will also focus on severe accident code development, assessment and validation. As the staff completes the research on severe accident issues that relate to current generation reactors, continued research will focus on efforts to independently evaluate the capability of new advanced light water reactor designs to withstand severe accidents

  8. Program Officer | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary Working as a member of one or two multi-disciplinary teams and under the guidance of a senior team member, Program Leader (PL) and/or Program Manager (PM) if applicable, the Program Officer (PO):

  9. Research Experience in Psychiatry Residency Programs Across Canada: Current Status

    Science.gov (United States)

    Shanmugalingam, Arany; Ferreria, Sharon G; Norman, Ross M G; Vasudev, Kamini

    2014-01-01

    Objective: To determine the current status of research experience in psychiatry residency programs across Canada. Method: Coordinators of Psychiatric Education (COPE) resident representatives from all 17 psychiatry residency programs in Canada were asked to complete a survey regarding research training requirements in their programs. Results: Among the 17 COPE representatives, 15 completed the survey, representing 88% of the Canadian medical schools that have a psychiatry residency program. Among the 15 programs, 11 (73%) require residents to conduct a scholarly activity to complete residency. Some of these programs incorporated such a requirement in the past 5 years. Ten respondents (67%) reported availability of official policy and (or) guidelines on resident research requirements. Among the 11 programs that have a research requirement, 10 (91%) require residents to complete 1 scholarly activity; 1 requires completion of 2 scholarly activities. Eight (53%) residency programs reported having a separate research track. All of the programs have a research coordinator and 14 (93%) programs provide protected time to residents for conducting research. The 3 most common types of scholarly activities that qualify for the mandatory research requirement are a full independent project (10 programs), a quality improvement project (8 programs), and assisting in a faculty project (8 programs). Six programs expect their residents to present their final work in a departmental forum. None of the residency programs require publication of residents’ final work. Conclusions: The current status of the research experience during psychiatry residency in Canada is encouraging but there is heterogeneity across the programs. PMID:25565474

  10. DIII-D research program progress

    Energy Technology Data Exchange (ETDEWEB)

    Stambaugh, R.D.

    1990-11-01

    A summary of highlights of the research on the DIII-D tokamak in the last two years is given. At low q, toroidal beta ({beta}{sub T}) has reached 11%. At high q, {epsilon}{beta}{sub p} has reached 1.8. DIII-D data extending from one regime to the other show the beta limit is at least {beta}{sub T}(%) {ge} 3.5 I/aB (MA, m, T). Prospects for using H-mode in future devices have been enhanced. The discovery of negative edge electric fields and associated turbulence suppression have become part of an emerging theory of H-mode. Long pulse (10 second) H-mode with impurity control has been demonstrated. Radial sweeping of the divertor strike points and gas puffing under the X-point have lowered peak divertor plate heat fluxes a factor of 3 and 2 respectively. T{sub i} = 17 keV has been reached in a hot ion H-mode. Electron cyclotron current drive (ECCD) has produced up to 70 kA of driven current. Program elements now beginning are fast wave current drive (FWCD) and an advanced divertor program (ADP). 38 refs., 10 figs.

  11. Defense Small Business Innovation Research Program (SBIR) FY 1985.

    Science.gov (United States)

    1985-01-31

    7 52. ’ %% P~ % .% PROGRAM SOLICITATION I Number 85.1 Small Business Innovation Research - Program Issue Date: 1 October 1984 I. U.S. Department...and % . . .... .27tr 0 ""’ •~ .’.. DOD PROGRAM SOLICITATION FOR SMALL BUSINESS INNOVATION RESEARCH 1.0 PROGRAM DESCRIPTION 1.1 Introduction Number...Components) invite small business firms to submit pro- DARPA 8 128 12 posals under this program solicitation entitled Small DNA 10 88 8 Business Innovation Research

  12. Defense Small Business Innovation Research Program (SBIR) FY 1984.

    Science.gov (United States)

    1984-01-12

    INNOVATION....... .. PROGRAM SOLICITATION* Number 84.1 Small Business Innovation Research ZA Program ... Dist. Issu Dat: 1 Octber 983-14 U.S...233 iv - epI DOD PROGRAM SOLICITATION FOR SMALL BUSINESS INNOVATION RESEARCH 1.0 PROGRAM DESCRIPTION 1.1 Introduction - The Department of Defense (DOD...as DOD Components) invite small bus- iness firms to submit proposals under this program solicitation entitled Small Business Innovation Research

  13. Overview of NASA's Microgravity Materials Research Program

    Science.gov (United States)

    Downey, James Patton; Grugel, Richard

    2012-01-01

    The NASA microgravity materials program is dedicated to conducting microgravity experiments and related modeling efforts that will help us understand the processes associated with the formation of materials. This knowledge will help improve ground based industrial production of such materials. The currently funded investigations include research on the distribution of dopants and formation of defects in semiconductors, transitions between columnar and dendritic grain morphology, coarsening of phase boundaries, competition between thermally and kinetically favored phases, and the formation of glassy vs. crystalline material. NASA microgravity materials science investigators are selected for funding either through a proposal in response to a NASA Research Announcement or by participation in a team proposing to a foreign agency research announcement. In the latter case, a US investigator participating in a successful proposal to a foreign agency can then apply to NASA for funding of an unsolicited proposal. The program relies on cooperation with other aerospace partners from around the world. The ISS facilities used for these investigations are provided primarily by partnering with foreign agencies and in most cases the US investigators are working as a part of a larger team studying a specific area of materials science. The following facilities are to be utilized for the initial investigations. The ESA provided Low Gradient Facility and the Solidification and Quench Inserts to the Materials Research Rack/Materials Science Laboratory are to be used primarily for creating bulk samples that are directionally solidified or quenched from a high temperature melt. The CNES provided DECLIC facility is used to observe morphological development in transparent materials. The ESA provided Electro-Magnetic Levitator (EML) is designed to levitate, melt and then cool samples in order to study nucleation behavior. The facility provides conditions in which nucleation of the solid is

  14. Transit Marketing : A Program of Research, Demonstration and Communication

    Science.gov (United States)

    1985-04-01

    This report recommends a five-year program of research, demonstration, and communication to improve the effectiveness of marketing practice in the U.S. transit industry. The program is oriented toward the development of improved market research tools...

  15. Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application.

    Science.gov (United States)

    Achilli, Cesare; Grandi, Stefania; Ciana, Annarita; Guidetti, Gianni F; Malara, Alessandro; Abbonante, Vittorio; Cansolino, Laura; Tomasi, Corrado; Balduini, Alessandra; Fagnoni, Maurizio; Merli, Daniele; Mustarelli, Piercarlo; Canobbio, Ilaria; Balduini, Cesare; Minetti, Giampaolo

    2014-04-01

    Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a (10)B-containing drug and subsequent irradiation with low energy neutrons, which bring about the decay of (10)B to (7)Li and an α particle, causing the death of the neoplastic cell. The effectiveness of BNCT is limited by the low delivery and accumulation of the used boron-containing compounds. Here we report the development and the characterization of BPO4 nanoparticles (NPs) as a novel possible alternative drug for BNCT. An extensive analysis of BPO4 NP biocompatibility was performed using both mature blood cells (erythrocytes, neutrophils and platelets) and a model of hematopoietic progenitor cells. A time- and concentration-dependent cytotoxicity study was performed on neoplastic coloncarcinoma and osteosarcoma cell lines. BPO4 functionalization with folic acid, introduced to improve the uptake by tumor cells, appeared to effectively limit the unwanted effects of NPs on the analyzed blood components. Boron neutron capture therapy (BNCT) is a radiotherapy treatment modality based on the accumulation of a (10)B-containing drug and subsequent irradiation with low energy neutrons, inducing the decay of (10)B to (7)Li and an α particle, causing neoplastic cell death. This team of authors reports on a folic acid functionalized BPO4 nanoparticle with improved characteristics compared with conventional BNCT approaches, as demonstrated in tumor cell lines, and hopefully to be followed by translational human studies. © 2014.

  16. 5 CFR 470.205 - Initiation of research programs.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Initiation of research programs. 470.205 Section 470.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT RESEARCH PROGRAMS AND DEMONSTRATIONS PROJECTS Regulatory Requirements Pertaining to Research Programs § 470.205 Initiation of...

  17. Fission reactor based epithermal neutron irradiation facilities for routine clinical application in BNCT-Hatanaka memorial lecture

    International Nuclear Information System (INIS)

    Harling, Otto K.

    2009-01-01

    Based on experience gained in the recent clinical studies at MIT/Harvard, the desirable characteristics of epithermal neutron irradiation facilities for eventual routine clinical BNCT are suggested. A discussion of two approaches to using fission reactors for epithermal neutron BNCT is provided. This is followed by specific suggestions for the performance and features needed for high throughput clinical BNCT. An example of a current state-of-the-art, reactor based facility, suited for routine clinical use is discussed. Some comments are provided on the current status of reactor versus accelerator based epithermal neutron sources for BNCT. This paper concludes with a summary and a few personal observations on BNCT by the author.

  18. P and T research program in Korea

    International Nuclear Information System (INIS)

    Park, C. K.

    1997-01-01

    The national energy demand is taking a sharp rise on account of the rapid growth of economy in Korea. Unfortunately, Korea has not much choice of alternative energy a promising option for Korea. For instance, eleven nuclear plants are in operation and 7 plants are under construction. Several plants are in planning stage. KAERI has played a major role in the design and operation of the plants in Korea. The spent fuel issue is calling for acute attention nationwide as the number of plants increases. Korea is actively seeking a technical solution to that problem surfacing on the horizon. A preliminary conceptual study on the P and T technology was performed from 1992 to 1996 and the future research directions were derived from that study. Because of the situation Korea is facing with, one of the major technical guidelines is that the P and T technology should be developed in compliance with the NPT. The concept of an accelerator driven subcritical system was found to be the most favorable option according to the conceptual study. KAERI set up an ambitious accelerator driven system development program for next 10 years. Key elementary technologies for a high current accelerator and a subcritical system are scheduled to be developed and experimented for the first five years (1997-2001). For the second five years (2002-2006), the accelerator program is pushed for the completion to parameters of 1 GeV, 20mA with capability to drive a subcritical system. For the subcritical system, a detail design study is to be performed and a small mockup system is to be built for bench scale test purpose

  19. AECL research programs in life sciences

    International Nuclear Information System (INIS)

    Marko, A.M.

    1981-04-01

    The present report summarizes the current research activities in life sciences in the Atomic Energy of Canada Limited-Research Company. The research is carried out at its two main research sites: the Chalk River Nuclear Laboratories and the Whiteshell Nuclear Research Establishment. The summaries cover the following areas of research: radiation biology, medical biophysics, epidemiology, environmental research and dosimetry. (author)

  20. The BNCT facility at the HFR Petten: Quality assurance for reactor facilities in clinical trials

    International Nuclear Information System (INIS)

    Moss, R.; Watkins, P.; Vroegindeweij, C.; Stecher-Rasmussen, F.; Huiskamp, R.; Ravensberg, K.; Appelman, K.; Sauerwein, W.; Hideghety, K.; Gabel, D.

    2001-01-01

    The first clinical trial in Europe of Boron Neutron Capture Therapy (BNCT) for the treatment of glioblastoma was opened in July 1997. The trial is a Phase I study with the principal aim to establish the maximum tolerated radiation dose and the dose limiting toxicity under defined conditions. It is the first time that a clinical application could be realised on a completely multi-national scale. The treatment takes place at the High Flux Reactor (HFR) in Petten, the Netherlands, is operated by an international team of experts under the leadership of a German radiotherapist, and treats patients coming from different European countries. It has therefore been necessary to create a very specialised organisation and contractual structure with the support of administrations from different countries, who had to find and adapt solutions within existing laws that had never foreseen such a situation. Furthermore, the treatment does not take place in an hospital environment and even more so, the facility is at a nuclear research reactor. Hence, special efforts were made on quality assurance, in order that the set-up at the facility and the personnel involved complied, as closely as possible, with similar practices in conventional radiotherapy departments. (author)

  1. Detailed dosimetry and clinical outcome analysis for the argentine BNCT trials of cutaneous nodular melanomas

    International Nuclear Information System (INIS)

    Gonzalez, S.J.; Santa Cruz, G.A.; Casal, M.R.

    2006-01-01

    Three female patients with biopsy-proven nodular melanoma were treated to six separate sites as part of the Phase I/II BNCT clinical trial conducted at the Comision Nacional de Energia Atomica (CNEA) and the Instituto A. Roffo, Argentina. This work reports on the detailed dosimetry for the clinical trials, and presents a preliminary analysis to investigate the possible influence of tumor size and total equivalent dose on the observed local tumor response. Also, the appropriateness of applying 3.5 tumor-to-blood 10 B concentration ratio for the BPA compound in nodular melanoma cases is discussed. The statistical analysis showed that tumor response depends not only on the dose but also, and highly, on the tumor size. For these three patients, there was no significant difference between minimum and mean equivalent doses as explicative for tumor response. The collection of sixteen experimental-based tumor-to-blood ratios determined by CNEA in nodular melanoma patients derived an average value and standard deviation of 2.5 ± 0.6. This result suggests that a lower ratio could be more suitable for estimating the clinical dosimetry. It is also consistent with the worse tumor control rate in nodular melanomas observed by other researchers. (author)

  2. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  3. Center Independent Research & Developments: JPL IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative projects are sought in the areas of basic research, fundamental research, applied research, development and systems and other concept formulation studies....

  4. BNCT clinical trials of skin melanoma patients in Argentina

    International Nuclear Information System (INIS)

    Roth, Berta M.; Bonomi, Marcelo R.; Gonzalez, Sara J.

    2006-01-01

    The clinical outcome of six skin melanoma BNCT irradiations is presented. Three patients (A, B and C), with multiple subcutaneous skin metastases progressed to chemotherapy were infused with ∼14 g/m 2 of boronophenylalanine ( 10 BPA)-fructose and irradiated in the hyperthermal neutron beam of the RA-6 reactor. Patient A received two one fraction irradiations in different areas of the leg, B received one fraction and C was irradiated in three consecutive fields at the calf, heel and foot sole. The maximum prescribed dose to normal skin ranged from 16.5 to 24 Gy-Eq. With a minimum follow-up of 10 months there was a G1 acute epithelitis in A and B and a G3 in C. No late toxicity was observed. Due to the in-field tumor-growth-delay and the absence of severe acute and/or late toxicity observed during the follow-up period, a dose-escalation trial is ongoing. (author)

  5. Liquid Li based neutron source for BNCT and science application.

    Science.gov (United States)

    Horiike, H; Murata, I; Iida, T; Yoshihashi, S; Hoashi, E; Kato, I; Hashimoto, N; Kuri, S; Oshiro, S

    2015-12-01

    Liquid lithium (Li) is a candidate material for a target of intense neutron source, heat transfer medium in space engines and charges stripper. For a medical application of BNCT, epithermal neutrons with least energetic neutrons and γ-ray are required so as to avoid unnecessary doses to a patient. This is enabled by lithium target irradiated by protons at 2.5 MeV range, with utilizing the threshold reaction of (7)Li(p,n)(7)Be at 1.88 MeV. In the system, protons at 2.5 MeV penetrate into Li layer by 0.25 mm with dissipating heat load near the surface. To handle it, thin film flow of high velocity is important for stable operation. For the proton accelerator, electrostatic type of the Schnkel or the tandem is planned to be employed. Neutrons generated at 0.6 MeV are gently moderated to epithermal energy while suppressing accompanying γ-ray minimum by the dedicated moderator assembly. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. FY 1995 research highlights: PNL accomplishments in OER programs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  7. Radiation shielding design of BNCT treatment room for D-T neutron source.

    Science.gov (United States)

    Pouryavi, Mehdi; Farhad Masoudi, S; Rahmani, Faezeh

    2015-05-01

    Recent studies have shown that D-T neutron generator can be used as a proper neutron source for Boron Neutron Capture Therapy (BNCT) of deep-seated brain tumors. In this paper, radiation shielding calculations have been conducted based on the computational method for designing a BNCT treatment room for a recent proposed D-T neutron source. By using the MCNP-4C code, the geometry of the treatment room has been designed and optimized in such a way that the equivalent dose rate out of the treatment room to be less than 0.5μSv/h for uncontrolled areas. The treatment room contains walls, monitoring window, maze and entrance door. According to the radiation protection viewpoint, dose rate results of out of the proposed room showed that using D-T neutron source for BNCT is safe. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Characterisation of an accelerator-based neutron source for BNCT versus beam energy

    CERN Document Server

    Agosteo, S; D'Errico, F; Nath, R; Tinti, R

    2002-01-01

    Neutron capture in sup 1 sup 0 B produces energetic alpha particles that have a high linear energy transfer in tissue. This results in higher cell killing and a higher relative biological effectiveness compared to photons. Using suitably designed boron compounds which preferentially localize in cancerous cells instead of healthy tissues, boron neutron capture therapy (BNCT) has the potential of providing a higher tumor cure rate within minimal toxicity to normal tissues. This clinical approach requires a thermal neutron source, generally a nuclear reactor, with a fluence rate sufficient to deliver tumorcidal doses within a reasonable treatment time (minutes). Thermal neutrons do not penetrate deeply in tissue, therefore BNCT is limited to lesions which are either superficial or otherwise accessible. In this work, we investigate the feasibility of an accelerator-based thermal neutron source for the BNCT of skin melanomas. The source was designed via MCNP Monte Carlo simulations of the thermalization of a fast ...

  9. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    1985-07-01

    The nuclear plant aging research described in this plan is intended to resolve issues related to the aging and service wear of equipment and systems at commercial reactor facilities and their possible impact on plant safety. Emphasis has been placed on identification and characterization of the mechansims of material and component degradation during service and evaluation of methods of inspection, surveillance, condition monitoring and maintenance as means of mitigating such effects. Specifically the goals of the program are as follows: (1) to identify and characterize aging and service wear effects which, if unchecked, could cause degradation of structures, components, and systems and thereby impair plant safety; (2) to identify methods of inspection, surveillance and monitoring, or of evaluating residual life of structures, components, and systems, which will assure timely detection of significant aging effects prior to loss of safety function; and (3) to evaluate the effectiveness of storage, maintenance, repair and replacement practices in mitigating the rate and extent of degradation caused by aging and service wear

  10. Forest productivity: an integrated research and development program

    Science.gov (United States)

    Daniel C. Dey; Thomas R. Crow; Don E. Riemenschneider

    2003-01-01

    In 2000, the North Central Research Station initiated the Forest Productivity Integrated Research Program (North Central Research Station 2001). This program combines the efforts of scientists from across the Station's 13 research work units to examine the current condition of the forests in the North Central Region and their prospects for producing wood and fiber...

  11. 78 FR 12033 - Programs and Research Projects Affecting the Arctic

    Science.gov (United States)

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office ] ARCTIC RESEARCH COMMISSION Programs and Research Projects Affecting the Arctic Notice is hereby given that the U.S. Arctic Research... programs and research projects affecting the Arctic. If you plan to attend this meeting, please notify us...

  12. Might iodomethyl-{alpha}-tyrosine be a surrogate for BPA in BNCT?

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.

    1996-12-31

    A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with {sup 10}B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that {sup 10}B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing {sup 18}F-fluoroboronophenylaianine [FBPA] as a positron {sup 18}F (T{sub 1/2} = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of {sup 123}I alpha methyltyrosine as a surrogate for BPA in BNCT.

  13. Might iodomethyl-α-tyrosine be a surrogate for BPA in BNCT?

    International Nuclear Information System (INIS)

    Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.

    1996-01-01

    A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with 10 B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that 10 B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing 18 F-fluoroboronophenylaianine [FBPA] as a positron 18 F (T 1/2 = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of 123 I alpha methyltyrosine as a surrogate for BPA in BNCT

  14. DECONTAMINATION SYSTEMS AND INFORMATION RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Echol E. Cook, Ph.D., PE.

    1998-11-01

    During the five plus years this Cooperative Agreement existed, more than 45 different projects were funded. Most projects were funded for a one year period but there were some, deemed of such quality and importance, funded for multiple years. Approximately 22 external agencies, businesses, and other entities have cooperated with or been funded through the WVU Cooperative Agreement over the five plus years. These external entities received 33% of the funding by this Agreement. The scope of this Agreement encompassed all forms of hazardous waste remediation including radioactive, organic, and inorganic contaminants. All matrices were of interest; generally soil, water, and contaminated structures. Economic, health, and regulatory aspects of technologies were also within the scope of the agreement. The highest priority was given to small businesses funded by the Federal Energy Technology Center (FETC) and Department of Energy (DOE) involved in research and development of innovative remediation processes. These projects were to assist in the removal of barriers to development and commercialization of these new technologies. Studies of existing, underdeveloped technologies, were preferred to fundamental research into remediation technologies. Sound development of completely new technologies was preferred to minor improvements in existing methods. Solid technological improvements in existing technologies or significant cost reduction through innovative redesign were the preferred projects. Development, evaluation, and bench scale testing projects were preferred for the WVU research component. In the effort to fill gaps in current remediation technologies, the worth of the WVU Cooperative Agreement was proven. Two great technologies came out of the program. The Prefabricated Vertical Drain Technology for enhancing soil flushing was developed over the 6-year period and is presently being demonstrated on a 0.10 acre Trichloroethylene contaminated site in Ohio. The Spin

  15. Horonobe Underground Research Program. A program on surveys and researches in fiscal year 2002

    International Nuclear Information System (INIS)

    2002-04-01

    Horonobe Underground Research Program take about 20 years from beginning to finishing of their surveys and researches, and will be carried out at three stages containing 'Surveys and researches step (SRS) from on-land (the first step)', 'SRS at excavation of levels (the second step)', and 'SRS at underground facility (the third step)'. This program is contents on surveys and researches to be carried out in fiscal year 2002, the third year of the first step. In this fiscal year, for development of survey technique on geological environment, after selecting establishing area of research institute, physical investigations, geological surveys, surface stratum water surveys, and trial boring surveys at the establishing area and its peripheral areas to collect geological environment data, are planned. And, successive trial excavation and long-term monitoring of groundwater pressure for development on geological monitoring engineering, setting of seismograph, GPS, and so on and their operations for study on long-term stability on geological environment, and in-room tests on setting of engineered barrier and low alkaline concrete materials for R and D on geological disposal, are also planned. (G.K.)

  16. Role of EPA in Asset Management Research – The Aging Water Infrastructure Research Program

    Science.gov (United States)

    This slide presentation provides an overview of the EPA Office of Research and Development’s Aging Water infrastructure Research Program (AWIRP). The research program origins, goals, products, and plans are described. The research program focuses on four areas: condition asses...

  17. Liposome and co-spray-dried PVP / o-carborane formulations for BNCT treatment of cancer

    OpenAIRE

    Olusanya, Temidayo; Stich, Theresia; Higgins, Samantha Caroline; Lloyd, Rhiannon Eleanor Iris; Pilkington, Geoffrey John; Fatouros, Dimitrios; Calabrese, Gianpiero; Smith, James Richard; Tsibouklis, John

    2015-01-01

    Purpose: Boron neutron capture therapy (BNCT) is a method for selectively destroying malignant (normally glioma) cells whilst sparing normal tissue. Irradiation of 10B (large neutron capture cross-section) with thermal neutrons effects the nuclear fission reaction: 10B + 1n → → 7Li+ + α + γ; where the penetration of α-particles and 7Li+ is only 8 and 5 µm, respectively, i.e., within a single cell thickness. Poor selectivity is the main reason why BNCT has not become a mainstream cancer therap...

  18. The Boron Neutron Capture Therapy (BNCT) Project at the TRIGA Reactor in Mainz, Germany

    DEFF Research Database (Denmark)

    Hampel, G.; Grunewald, C.; Schütz, C.

    2011-01-01

    The thermal column of the TRIGA reactor in Mainz is being used very effectively for medical and biological applications. The BNCT (boron neutron capture therapy) project at the University of Mainz is focussed on the treatment of liver tumours, similar to the work performed at Pavia (Italy) a few...... have also been initiated to investigate radiobiological effects of radiation generated during BNCT. For both experiments and treatment, a reliable dosimetry system is necessary. From work elsewhere, the use of alanine detectors appear to be an appropriate dosimetry technique....

  19. Experimental study on the performance of an epithermal neutron flux monitor for BNCT.

    Science.gov (United States)

    Guan, Xingcai; Manabe, Masanobu; Tamaki, Shingo; Liu, Shuangtong; Sato, Fuminobu; Murata, Isao; Wang, Tieshan

    2016-07-01

    The performance of an epithermal neutron (0.5eVflux monitor designed for boron neutron capture therapy (BNCT) was experimentally studied by using a prototype monitor in an appropriate neutron field at the intense deuterium-tritium neutron source facility OKTAVIAN of Osaka University, Japan. It was convinced from the experimental results that the developed monitor worked well and the epithermal neutron fluxes in BNCT neutron sources can be measured within 5% by the monitor. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Heavy Truck Clean Diesel Cooperative Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Milam, David

    2006-12-31

    This report is the final report for the Department of Energy on the Heavy Truck Engine Program (Contract No. DE-FC05-00OR22806) also known as Heavy Truck Clean Diesel (HTCD) Program. Originally, this was scoped to be a $38M project over 5 years, to be 50/50 co-funded by DOE and Caterpillar. The program started in June 2000. During the program the timeline was extended to a sixth year. The program completed in December 2006. The program goal was to develop and demonstrate the technologies required to enable compliance with the 2007 and 2010 (0.2g/bhph NOx, 0.01g/bhph PM) on-highway emission standards for Heavy Duty Trucks in the US with improvements in fuel efficiency compared to today's engines. Thermal efficiency improvement from a baseline of 43% to 50% was targeted.

  1. PISCES program plasma-surface interactions research

    International Nuclear Information System (INIS)

    1989-05-01

    This paper discusses the following about the Pisces program: Major objectives of the program; Staff in the PISCES program at UCLA; Highlights in the program; Collaborations with other institutions; PISCES-A facility; PISCES-B facility; Fast scanning Langmuir probe; Omegatron mass spectrometer; Spectroscopic diagnostics; Data acquisition system; Redeposition effect on carbon chemical erosion; Erosion of carbon tokamakium from TFTR; Effect of boron-doping on carbon chemical erosion; Radiation enhanced sublimation of carbon; Surface analysis of TEXTOR titles; Spectroscopic analysis of carbon impurities; Biased limiter and divertor; Biased divertor channel; Gaseous divertor experiments; Presheath profile measurements; Particle transport in CCT tokamak; and Biased divertor experiments in CCT

  2. Ecological Research Division Theoretical Ecology Program. [Contains abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-01

    This report presents the goals of the Theoretical Ecology Program and abstracts of research in progress. Abstracts cover both theoretical research that began as part of the terrestrial ecology core program and new projects funded by the theoretical program begun in 1988. Projects have been clustered into four major categories: Ecosystem dynamics; landscape/scaling dynamics; population dynamics; and experiment/sample design.

  3. Research of the Rio Grande Ecosystem Management Program

    Science.gov (United States)

    Deborah M. Finch

    2000-01-01

    This paper describes the mission, objectives, and preliminary results of the Middle Rio Grande Ecosystem Management Research Program managed at the Rocky Mountain Research Station's Albuquerque laboratory. This program was initiated in 1994 to address growing pressures to effectively manage the limited resources of the middle Rio Grande Basin. The program is...

  4. Summer Undergraduate Breast Cancer Research Program

    National Research Council Canada - National Science Library

    Folk, William

    2002-01-01

    .... These students participated in faculty-mentored research projects for eight weeks and participated in seminars, brown-bag lunches, and specialty discussion on research, clinical trials, career...

  5. Examining Burma's Development: A Research Fellowship Program ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Regional Center for Social Science and Sustainable Development (RCSD) at Thailand's Chiang Mai University will manage the four-year program, which targets junior and mid-level academic and non-academic Burmese scholars. The program will ... LVIF announces five more funded projects. Eleven world-class ...

  6. Programs and Research Advisor | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Analysis of trends and policy developments in the Sub-Saharan African Region in order to support IDRC's strategic plan and programming by: collating various information and data relevant to IDRC programs in the region through consultation of print and electronic sources and internal and external network of contacts; ...

  7. Programs | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    We help bring ideas to life. Our development programs support innovative solutions that improve global access to food, jobs, health, and technologies for growth. At IDRC, we have learned that the greatest benefit comes from focusing our investments to deliver large-scale impact. Our programs seek answers that drive ...

  8. Pacific Northwest Laboratory Alaska (ARCTIC) research program

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, W.C.; Eberhardt, L.E.

    1980-03-01

    The current program continues studies of arctic ecosystems begun in 1959 as part of the Cape Thompson Program. Specific ecosystem aspects include studies of the ecology of arctic and red foxes, small mammel and bird population studies, lichen studies, and radiation ecology studies. (ACR)

  9. The United States Advanced Reactor Technologies Research and Development Program

    International Nuclear Information System (INIS)

    O’Connor, Thomas J.

    2014-01-01

    The following aspects are addressed: • Nuclear energy mission; • Reactor research development and deployment (RD&D) programs: - Light Water Reactor Sustainability Program; - Small Modular Reactor Licensing Technical Support; - Advanced Reactor Technologies (ART)

  10. Towards a new therapy protocol for liver metastases. Effect of boron compounds and BNCT on normal liver regeneration

    International Nuclear Information System (INIS)

    Cardoso, Jorge E.; Heber, Elisa M.; Trivillin, Veronica A.

    2006-01-01

    The Taormina project developed a new method for BNCT treatment of multifocal unresectable liver metastases based on whole liver autograft. The Roffo Institute liver surgeons propose a new technique based on partial liver autograft that would pose less risk to the patient but would require significant healthy liver regeneration following BNCT. The aim of the present study was to assess the effect of BPA, GB-10 (Na 2 10 B 10 H 10 ) and (GB-10 + BPA) and of BNCT mediated by these boron compounds on normal liver regeneration in the Wistar rat. Normal liver regeneration, body weight, hemogram, liver and kidney function were assessed following partial hepatectomy post administration of BPA, GB-10 or (GB-10 + BPA) and post in vivo BNCT at the RA-6 Reactor. These end-points were evaluated 9 days following partial hepatectomy, the time at which complete liver regeneration occurs in untreated controls. The corresponding biodistribution studies were conducted to perform dosimetric calculations. BPA, GB-10 and (GB-10 + PBA) and in vivo BNCT mediated by these boron compounds in dose ranges compatible with therapy did not cause alterations in the outcome of normal liver regeneration, and did not induce alterations in body weight, hemogram, liver or kidney function. The experimental data available to date support the development of a new BNCT protocol for the treatment of liver metastases that requires the regeneration of normal liver past-BNCT. (author)

  11. The Army Family Research Program: the Research Plan

    Science.gov (United States)

    1990-09-01

    NJ: General Learning Press. Sprenkle, D. H., & Olson, D. H. (1978). Circumplex model of marital systems. An empirical study of clinic and nonclinic...Family Action Plans (1984-1990) by developing databases, models , program evaluation technologies, and policy options that assist the Army to retain...wrote descriptions of the Annual Survey of Army Families (ASAF), and the Model Spouse Employment Program. Bob Sadacca and Mary Kralj wrote the Project A

  12. Situated Research Design and Methodological Choices in Formative Program Evaluation

    Science.gov (United States)

    Supovitz, Jonathan

    2013-01-01

    Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

  13. DoD Small Business Innovation Research Program

    Science.gov (United States)

    2009-01-30

    The DoD IG evaluated whether Military Departments and the Defense Advanced Research Projects Agency (DARPA) effectively used the Small Business ... Innovation Research (SBIR) program for research and development projects to meet DoD requirements and whether projects developed for the SBIR program

  14. Advanced Pediatric Brain Imaging Research and Training Program

    Science.gov (United States)

    2017-10-01

    Award Number: W81XWH-11-2-0198 TITLE: Advanced Pediatric Brain Imaging Research and Training Program PRINCIPAL INVESTIGATOR: Catherine...TITLE AND SUBTITLE 5a. CONTRACT NUMBER Advanced Pediatric Brain Imaging Research and Training Program 5b. GRANT NUMBER W81XWH-11-2-0198 5c. PROGRAM...13. SUPPLEMENTARY NOTES 14. ABSTRACT The focus of our BRAIN training program over the past year of the project is to successfully convert the

  15. Research plan on Horonobe Underground Research Program. Result report on survey research in fiscal year 2000

    International Nuclear Information System (INIS)

    2001-07-01

    The Horonobe Underground Research Center planned to construct at Horonobe-town in Hokkaido by the Japan Nuclear Cycle Development Institute (JNC), is one of research facilities on deep underground shown in item on processing and disposal of the radioactive wastes in the 'long-term program on research, development and application on nuclear energy', and is planned to carry out a study on deep underground at an object of the sedimentary rocks. This report is summary of results on survey research carried out at 2000 fiscal year. Here was described on a summary of results on survey research carried out in 2000 fiscal year according to the 'Survey Research Plan in Fiscal Year 2000 of the Underground Research Laboratory (temporary name) Project'. As the Horonobe deep stratum research plan is established to carry out under three steps of 'survey research from earth surface', 'survey research under excavation of a tunnel', and 'survey research under application of the tunnel'. In fiscal year 2000, the first step of the survey research from earth surface' was begun from March, 2001. And, on study on geological science and R and D on stratum disposal, together with intending of concrete execution of survey research contents, a part of literature survey was begun. On a survey actually performed at site, in the environmental survey, the hearing investigation on inhabiting situation of rare flora and fauna, and situation of utilization of the groundwater of Horonobe town were carried out. (G.K.)

  16. Abscopal effect of boron neutron capture therapy (BNCT). Proof of principle in an experimental model of colon cancer

    Energy Technology Data Exchange (ETDEWEB)

    Trivillin, Veronica A.; Monti Hughes, Andrea; Schwint, Amanda E. [Comision Nacional de Energia Atomica (CNEA), Department of Radiobiology, B1650KNA San Martin, Provincia Buenos Aires (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Ciudad Autonoma de Buenos Aires (Argentina); Pozzi, Emiliano C.C.; Curotto, Paula [Centro Atomico Ezeiza, Comision Nacional de Energia Atomica (CNEA), Department of Research and Production Reactors, Provincia Buenos Aires (Argentina); Colombo, Lucas L. [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Ciudad Autonoma de Buenos Aires (Argentina); Instituto de Oncologia Angel H. Roffo, Ciudad Autonoma de Buenos Aires (Argentina); Thorp, Silvia I.; Farias, Ruben O. [Comision Nacional de Energia Atomica (CNEA), Department of Instrumentation and Control, Provincia Buenos Aires (Argentina); Garabalino, Marcela A. [Comision Nacional de Energia Atomica (CNEA), Department of Radiobiology, B1650KNA San Martin, Provincia Buenos Aires (Argentina); Gonzalez, Sara J. [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Ciudad Autonoma de Buenos Aires (Argentina); Comision Nacional de Energia Atomica (CNEA), Department of Instrumentation and Control, Provincia Buenos Aires (Argentina); Santa Cruz, Gustavo A. [Comision Nacional de Energia Atomica (CNEA), Department of Boron Neutron Capture Therapy, Provincia Buenos Aires (Argentina); Carando, Daniel G. [Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Ciudad Autonoma de Buenos Aires (Argentina); Universidad de Buenos Aires, Faculty of Exact and Natural Sciences, Ciudad Autonoma de Buenos Aires (Argentina)

    2017-11-15

    The aim of the present study was to evaluate, for the first time, the abscopal effect of boron neutron capture therapy (BNCT). Twenty-six BDIX rats were inoculated subcutaneously with 1 x 10{sup 6} DHD/K12/TRb syngeneic colon cancer cells in the right hind flank. Three weeks post-inoculation, the right leg of 12 rats bearing the tumor nodule was treated with BPA-BNCT (BPA-Boronophenylalanine) at the RA-3 nuclear reactor located in Buenos Aires, Argentina, at an absorbed dose of 7.5 Gy to skin as the dose-limiting tissue. The remaining group of 14 tumor-bearing rats were left untreated and used as control. Two weeks post-BNCT, 1 x 10{sup 6} DHD/K12/TRb cells were injected subcutaneously in the contralateral left hind flank of each of the 26 BDIX rats. Tumor volume in both legs was measured weekly for 7 weeks to determine response to BNCT in the right leg and to assess a potential influence of BNCT in the right leg on tumor development in the left leg. Within the BNCT group, a statistically significant reduction was observed in contralateral left tumor volume in animals whose right leg tumor responded to BNCT (post-treatment/pre-treatment tumor volume <1) versus animals who failed to respond (post/pre ≥1), i.e., 13 ± 15 vs 271 ± 128 mm{sup 3}. In addition, a statistically significant reduction in contralateral left leg tumor volume was observed in BNCT-responsive animals (post/pre <1) vs untreated animals, i.e., 13 ± 15 vs 254 ± 251 mm{sup 3}. The present study performed in a simple animal model provides proof of principle that the positive response of a tumor to BNCT is capable of inducing an abscopal effect. (orig.)

  17. Abscopal effect of boron neutron capture therapy (BNCT). Proof of principle in an experimental model of colon cancer

    International Nuclear Information System (INIS)

    Trivillin, Veronica A.; Monti Hughes, Andrea; Schwint, Amanda E.; Pozzi, Emiliano C.C.; Curotto, Paula; Colombo, Lucas L.; Thorp, Silvia I.; Farias, Ruben O.; Garabalino, Marcela A.; Gonzalez, Sara J.; Santa Cruz, Gustavo A.; Carando, Daniel G.

    2017-01-01

    The aim of the present study was to evaluate, for the first time, the abscopal effect of boron neutron capture therapy (BNCT). Twenty-six BDIX rats were inoculated subcutaneously with 1 x 10 6 DHD/K12/TRb syngeneic colon cancer cells in the right hind flank. Three weeks post-inoculation, the right leg of 12 rats bearing the tumor nodule was treated with BPA-BNCT (BPA-Boronophenylalanine) at the RA-3 nuclear reactor located in Buenos Aires, Argentina, at an absorbed dose of 7.5 Gy to skin as the dose-limiting tissue. The remaining group of 14 tumor-bearing rats were left untreated and used as control. Two weeks post-BNCT, 1 x 10 6 DHD/K12/TRb cells were injected subcutaneously in the contralateral left hind flank of each of the 26 BDIX rats. Tumor volume in both legs was measured weekly for 7 weeks to determine response to BNCT in the right leg and to assess a potential influence of BNCT in the right leg on tumor development in the left leg. Within the BNCT group, a statistically significant reduction was observed in contralateral left tumor volume in animals whose right leg tumor responded to BNCT (post-treatment/pre-treatment tumor volume <1) versus animals who failed to respond (post/pre ≥1), i.e., 13 ± 15 vs 271 ± 128 mm 3 . In addition, a statistically significant reduction in contralateral left leg tumor volume was observed in BNCT-responsive animals (post/pre <1) vs untreated animals, i.e., 13 ± 15 vs 254 ± 251 mm 3 . The present study performed in a simple animal model provides proof of principle that the positive response of a tumor to BNCT is capable of inducing an abscopal effect. (orig.)

  18. Karlsruhe Nuclear Research Center. Research and development program 1991

    International Nuclear Information System (INIS)

    1990-01-01

    The R and D activities of the KfK are classified in 8 main research activities: 1) project nuclear fusion; 2) project pollutant mitigation in the environment; 3) solid state and materials research; 4) nuclear and elementary particle physics; 5) microtechnics e.g. X-ray lithography; 6) materials handling; 7) project nuclear safety research; 8) radioactive waste management. (orig.) [de

  19. Nuclear plant aging research program activities

    International Nuclear Information System (INIS)

    Eissenberg, D.M.

    1986-01-01

    The objective of this program is to provide recommendations for use by NRC regarding the availability and capability of diagnostic methods for assuring the operational readiness of NPP safety systems and components

  20. Geothermal Energy Research Development and Demonstration Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The Federal program's goal, strategy, plans, and achievements are summarized. In addition, geothermal development by state and local governments and, where available, by the private sector is described. (MHR)

  1. Summer Undergraduate Breast Cancer Research Program

    National Research Council Canada - National Science Library

    Folk, William

    2003-01-01

    ...) supported 6 students in 2002. These students participated in faculty-mentored research projects for eight weeks and participated in seminars, brown-bag lunches, and specialty discussions on research, clinical trials, career...

  2. Summer Undergraduate Breast Cancer Research Program

    National Research Council Canada - National Science Library

    Folk, William R; Blockus, Linda

    2004-01-01

    ...) supported 4 students in 2003. These students participated in faculty-mentored research projects for eight weeks and participated in seminars, brown-bag lunches, and specialty discussions on research, clinical trials, career...

  3. About the Epidemiology and Genomics Research Program

    Science.gov (United States)

    Epidemiology is the scientific study of the causes and distribution of disease in populations. NCI-funded epidemiology research is conducted through research at institutions in the United States and internationally.

  4. Predoctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Stern, David F

    2004-01-01

    .... This means that research on breast cancer has finally advanced to the stage where a concentrated effort in translational research will yield great strides in detection, diagnosis, and treatment...

  5. Federal Geothermal Research Program Update - Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Laney, P.T.

    2002-08-31

    This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  6. "Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

    Energy Technology Data Exchange (ETDEWEB)

    Ana J. Molinari; Andrea Monti Hughes; Elisa M. Heber; Marcela A. Garabalino; Veronica A. Trivillin; Amanda E. Schwint; Emiliano C. C. Pozzi; Maria E. Itoiz; Silvia I. Thorp; Romina F. Aromando; David W. Nigg; Jorge Quintana; Gustavo A. Santa Cruz

    2011-04-01

    Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (<10 {micro}m) would limit the damage to cells containing 10B (1,2). Thus, BNCT would target tumor tissue selectively, sparing normal tissue. Clinical trials of BNCT for the treatment of glioblastoma multiforme and/or melanoma and, more recently, head and neck tumors and liver metastases, using boronophenylalanine (BPA) or sodium mercaptoundecahydrododecaborane (BSH) as the 10B carriers, have been performed or are underway in Argentina, Japan, the US and Europe (e.g. 3-8). To date, the clinical results have shown a potential, albeit inconclusive, therapeutic advantage for this technique. Contributory translational studies have been carried out employing a variety of experimental models based on the implantation of tumor cells in normal tissue (e.g. 5).

  7. Earthquake engineering research program in Chile

    Science.gov (United States)

    Saragoni, G. R.

    1982-01-01

    Earthquake engineering research in Chile has been carried out for more than 30 years. Systematic research is done at the university of Chile in Santiago. Other universities such as the Catholic University, university of Concepcion, and the Federico Santa Maria Technical University have begun to teach and conduct research in earthquake engineering in recent years. 

  8. 2-O-α-glucopytanosyl L-ascorbic acid reduced mutagenicity at HPRT locus of mouse splenocytes following BNCT

    International Nuclear Information System (INIS)

    Kinashi, Yuko; Masunaga, Shin-ichiro; Suzuki, Minoru; Nagata, Kanji; Ono, Koji

    2006-01-01

    In boron neutron capture therapy (BNCT), normal tissue surrounding the tumor cells sometimes take up boron compounds resulting in radiation-induced damage to normal tissue. We have previously reported the evidence for increased the mutagenicity of thermal neutron in the presence of boron. In addition, we described the biological radio-protective effects of the ascorbic acid for mutation induction following BNCT in vitro. Here, we investigated these radio-protective effects of ascorbic acid for mutation induction in mouse splenocytes on HPRT locus following a BNCT study in vivo. (author)

  9. Tumor blood vessel "normalization" improves the therapeutic efficacy of boron neutron capture therapy (BNCT) in experimental oral cancer

    Energy Technology Data Exchange (ETDEWEB)

    D. W. Nigg

    2012-01-01

    We previously demonstrated the efficacy of BNCT mediated by boronophenylalanine (BPA) to treat tumors in a hamster cheek pouch model of oral cancer with no normal tissue radiotoxicity and moderate, albeit reversible, mucositis in precancerous tissue around treated tumors. It is known that boron targeting of the largest possible proportion of tumor cells contributes to the success of BNCT and that tumor blood vessel normalization improves drug delivery to the tumor. Within this context, the aim of the present study was to evaluate the effect of blood vessel normalization on the therapeutic efficacy and potential radiotoxicity of BNCT in the hamster cheek pouch model of oral cancer.

  10. Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Nigg; William Bauer; Various Others

    2014-06-01

    Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70–85 ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

  11. Fusion Energy Postdoctoral Research Program, Professional Development Program: FY 1987 annual report

    International Nuclear Information System (INIS)

    1988-01-01

    In FY 1986, Oak Ridge Associated Universities (ORAU) initiated two programs for the US Department of Energy (DOE), Office of Fusion Energy (OFE): the Fusion Energy Postdoctoral Research Program and the Fusion Energy Professional Development Program. These programs provide opportunities to conduct collaborative research in magnetic fusion energy research and development programs at DOE laboratories and contractor sites. Participants become trained in advanced fusion energy research, interact with outstanding professionals, and become familiar with energy-related national issues while making personal contributions to the search for solutions to scientific problems. Both programs enhance the national fusion energy research and development effort by providing channels for the exchange of scientists and engineers, the diffusion of ideas and knowledge, and the transfer of relevant technologies. These programs, along with the Magnetic Fusion Energy Science and Technology Fellowship Programs, compose the fusion energy manpower development programs administered by ORAU for DOE/OFE

  12. Neutron-photon mixed field dosimetry by TLD-700 glow curve analysis and its implementation in dose monitoring for Boron Neutron Capture Therapy (BNCT) treatments

    Energy Technology Data Exchange (ETDEWEB)

    Boggio, E. F.; Longhino, J. M. [Centro Atomico Bariloche, Departamento de Fisica de Reactores y Radiaciones / CNEA, Av. E. Bustillo Km 9.5, R8402AGP San Carlos de Bariloche (Argentina); Andres, P. A., E-mail: efboggio@cab.cnea.gov.ar [Centro Atomico Bariloche, Division Proteccion Radiologica / CNEA, Av. E. Bustillo Km 9.5, R8402AGP San Carlos de Bariloche (Argentina)

    2015-10-15

    BNCT is a cancerous cells selective, non-conventional radiotherapy modality to treat malignant tumors such as glioblastoma, melanoma and recurrent head and neck cancer. It consists of a two-step procedure: first, the patient is injected with a tumor localizing drug containing a non-radioactive isotope (Boron-10) with high slow neutron capture cross-section. In a second step, the patient is irradiated with neutrons, which are absorbed by the Boron-10 agent with the subsequently nuclear reaction B- 10(n,a)Li-7, thereby resulting in dose at cellular level due to the high-Let particles. The neutron fields suitable for BNCT are characterized by high neutron fluxes and low gamma dose. Determination of each component is not an easy task, especially when the volume of measurement is quite small or inaccessible for a miniature ionization chamber, for example. A method of measuring the photon and slow neutron dose(mainly by N-14 and B-10) from the glow curve (GC) analysis of a single {sup 7}LiF thermoluminescence detector is evaluated. This method was suggested by the group headed by Dr. Grazia Gambarini. The dosemeters used were TLD-600 ({sup 6}LiF:Mg,Ti with 95.6% {sup 6}Li) and TLD-700 ({sup 7}LiF:Mg,Ti with 99.9% {sup 7}LiF) from Harshaw. Photon dose measurement using the GC analysis method with TLD-700 in mixed fields requires the relation of the two main peaks of a TLD-600 GC shape obtained from an exposition to the same neutron field, and a photon calibrated GC with TLD-700. The requirements for slow neutron dose measurements are similar. In order to properly apply the GC analysis method at the Ra-6 Research Reactor BNCT facility, measurements were carried out in a standard water phantom, fully characterized on the BNCT beam by conventional techniques (activation detectors and paired ionization chambers technique). Next, the method was implemented in whole body dose monitoring of a patient undergoing a BNCT treatment, using a Bo MAb (Bottle Manikin Absorption) phantom

  13. Radiobiology studies for the evaluation of epithermal neutron beams used for BNCT

    International Nuclear Information System (INIS)

    Green, S.; Jones, B.; Mill, A.J.

    2006-01-01

    This paper outlines our plans for a study to establish the radiobiological effectiveness of the various mixes of radiation components present in an epithermal neutron beam designed for BNCT and to incorporate these data into clinical protocols for the treatment of malignant glioma. This is a description of work which is funded and just now beginning in Birmingham so no results can be presented. Our project will involve a combination of experimental measurements carried out in Birmingham and in Boston and mathematical modelling carried out in Birmingham. Despite all the extant in-vitro and in-vivo work, there is no widely accepted method to determine biological effect by accounting for variations in beam component mix, dose rate and treatment fractionation for disparate from the various BNCT centres. The objectives of this study are: To develop a cell-based radiobiology protocol to provide essential data on safety and efficacy of beams for Boron Neutron Capture Therapy (BNCT) in advance of clinical trials. To exploit the facilities at Massachusetts Institute of Technology for variable dose-rate epithermal irradiations to validate the above protocol. To develop mathematical models of this radiobiological system that can be used to inform decisions on dose selection, fractionation schedules, BNCT use as supplementary boosts or for re-treatment of recurrent cancers. To provide fundamental data relevant to the understanding of the radiobiology of simultaneous mixed high-and low-LET radiations over a clinically relevant dose-range. (author)

  14. Time factor of BSH from intravenous infusion to neutron irradiation for BNCT in patients with glioblastoma

    International Nuclear Information System (INIS)

    Kageji, T.; Nagahiro, S.; Kitamura, K.; Nakagawa, Y.; Hatanaka, H.; Haritz, D.; Grochulla, F.; Haselsberger, K.; Gabel, D.

    2000-01-01

    The present report evaluates the time factor of BSH from infusion to irradiation in patients with glioblastoma as a cooperative study in Europe and Japan. For BNCT with BSH after intravenous infusion, this work confirms that the planned neutron irradiation after intravenous BSH infusion appears to be optimal around 12-19 hours after the infusion. (author)

  15. Radiobiology of BNCT mediated by GB-10 and GB-10+BPA in experimental oral cancer

    International Nuclear Information System (INIS)

    Trivillin, Veronica A.; Heber, Elisa M.; Itoiz, Maria E.; Nigg, David; Calzetta, Osvaldo; Blaumann, Herman; Longhino, Juan; Schwint, Amanda E.

    2004-01-01

    We previously reported biodistribution and pharmacokinetic data for GB-10 (Na 2 10 B 10 H 10 ) and the combined administration of GB-10 and boronophenylalanine (BPA) as boron delivery agents for boron neutron capture therapy (BNCT) in the hamster cheek pouch oral cancer model. The aim of the present study was to assess, for the first time, the response of hamster cheek pouch tumors, precancerous tissue and normal tissue to BNCT mediated by GB-10 and BNCT mediated by GB-10 and BPA administered jointly using the thermalized epithermal beam of the RA-6 Reactor at the Bariloche Atomic Center. GB-10 exerted 75.5% tumor control (partial+complete remission) with no damage to precancerous tissue around tumor or to normal tissue. Thus, GB-10 proved to be a therapeutically efficient boron agent in this model despite the fact that it is not taken up selectively by oral tumor tissue. GB-10 exerted a selective effect on tumor blood vessels leading to significant tumor control with a sparing effect on normal tissue. BNCT mediated by the combined administration of GB-10 and BPA resulted in a reduction in the dose to normal tissue and would thus allow for significant escalation of dose to tumor without exceeding normal tissue tolerance

  16. First tomographic image of neutron capture rate in a BNCT facility

    Energy Technology Data Exchange (ETDEWEB)

    Minsky, D.M., E-mail: minsky@tandar.cnea.gov.ar [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina)] [Conicet, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Valda, A.A. [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina); Kreiner, A.J. [Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)] [Escuela de Ciencia y Tecnologia, , UNSAM, M. de Irigoyen 3100 (1650), San Martin, Prov. Bs. As. (Argentina)] [Conicet, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires (Argentina); Green, S.; Wojnecki, C. [School of Physics and Astronomy, University of Birmingham, B15 2 TT (United Kingdom)] [Department of Medical Physics, University Hospital Birmingham, Birmingham B15 2TH (United Kingdom); Ghani, Z. [Department of Medical Physics, University Hospital Birmingham, Birmingham B15 2TH (United Kingdom)

    2011-12-15

    This work discusses the development of online dosimetry of the boron dose via Single Photon Emission Computed Tomography (SPECT) during a BNCT treatment irradiation. Such a system will allow the online computation of boron dose maps without the large current uncertainties in the assessment of the boron concentration in different tissues. The first tomographic boron dose image with a SPECT prototype is shown.

  17. Otolaryngology Residency Program Research Resources and Scholarly Productivity.

    Science.gov (United States)

    Villwock, Jennifer A; Hamill, Chelsea S; Nicholas, Brian D; Ryan, Jesse T

    2017-06-01

    Objective To delineate research resources available to otolaryngology residents and their impact on scholarly productivity. Study Design Survey of current otolaryngology program directors. Setting Otolaryngology residency programs. Subjects and Methods An anonymous web-based survey was sent to 98 allopathic otolaryngology training program directors. Fisher exact tests and nonparametric correlations were used to determine statistically significant differences among various strata of programs. Results Thirty-nine percent (n = 38) of queried programs responded. Fourteen (37%) programs had 11 to 15 full-time, academic faculty associated with the residency program. Twenty (53%) programs have a dedicated research coordinator. Basic science lab space and financial resources for statistical work were present at 22 programs (58%). Funding is uniformly provided for presentation of research at conferences; a minority of programs (13%) only funded podium presentations. Twenty-four (63%) have resident research requirements beyond the Accreditation Council for Graduate Medical Education (ACGME) mandate of preparing a "manuscript suitable for publication" prior to graduation. Twenty-five (67%) programs have residents with 2 to 3 active research projects at any given time. None of the investigated resources were significantly associated with increased scholarly output. There was no uniformity to research curricula. Conclusions Otolaryngology residency programs value research, evidenced by financial support provided and requirements beyond the ACGME minimum. Additional resources were not statistically related to an increase in resident research productivity, although they may contribute positively to the overall research experience during training. Potential future areas to examine include research curricula best practices, how to develop meaningful mentorship and resource allocation that inspires continued research interest, and intellectual stimulation.

  18. Karlsruhe Nuclear Research Center. Research and development program 1992

    International Nuclear Information System (INIS)

    1991-01-01

    The KfK R and D activities are classified by ten point-of-main-effort projects: 1) low-pollution/low-waste methods, 2) environmental energy and mass transfers, 3) nuclear fusion, 4) nuclear saftey research, 5) radioactive waste management, 6) superconduction, 7) microtechnics, 8) materials handling, 9) materials and interfaces, 10) basic physical research. (orig.) [de

  19. Infectious Disease Clinical Research Program (IDCRP)

    Data.gov (United States)

    Federal Laboratory Consortium — Our mission is to conduct infectious disease clinical research of importance to the military through a unique, adaptive, and collaborative network, to inform health...

  20. U.S. Global Change Research Program Budget Crosscut

    Data.gov (United States)

    Office of Science and Technology Policy, Executive Office of the President — U.S. Global Change Research Program budget authority for Agency activities in which the primary focus is on:Observations, research, and analysis of climate change...

  1. 76 FR 314 - Sorghum Promotion, Research, and Information Program: Referendum

    Science.gov (United States)

    2011-01-04

    ... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-10-0103] Sorghum Promotion, Research, and Information Program: Referendum AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice of Opportunity to Participate in the Sorghum Promotion, Research, and Information...

  2. Program Leader | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... range from 30 to 100 activities with a value of $10 to 20 million;; Liaises with the DPA and Regional Directors (RDs) (i.e. senior management) on issues of program and project development and management;; Is responsible for the PI team's and IDRC's contacts with other international agencies and Canadian institutions; ...

  3. The NASA computer science research program plan

    Science.gov (United States)

    1983-01-01

    A taxonomy of computer science is included, one state of the art of each of the major computer science categories is summarized. A functional breakdown of NASA programs under Aeronautics R and D, space R and T, and institutional support is also included. These areas were assessed against the computer science categories. Concurrent processing, highly reliable computing, and information management are identified.

  4. Underlying chemistry research for the nuclear fuel waste management program

    International Nuclear Information System (INIS)

    Torgerson, D.F.; Sagert, N.H.; Shoesmith, D.W.; Taylor, P.

    1984-04-01

    This document reviews the underlying chemistry research part of the Canadian Nuclear Fuel Waste Management Program, carried out in the Research Chemistry Branch. This research is concerned with developing the basic chemical knowledge and under-standing required in other parts of the Program. There are four areas of underlying research: Waste Form Chemistry, Solute and Solution Chemistry, Rock-Water-Waste Interactions, and Abatement and Monitoring of Gas-Phase Radionuclides

  5. ANSTO - Program of Research 1994-1995

    International Nuclear Information System (INIS)

    1994-01-01

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO's scientific and engineering activities is also included. ills

  6. ANSTO - Program of Research 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO`s scientific and engineering activities is also included. ills.

  7. Logic Estimation of the Optimum Source Neutron Energy for BNCT of Brain Tumors

    International Nuclear Information System (INIS)

    Dorrah, M.A.; Gaber, F.A.; Abd Elwahab, M.A.; Kotb, M.A.; Mohammed, M.M.

    2012-01-01

    BNCT is very complicated technique; primarily due to the complexity of element composition of the brain. Moreover; numerous components contributes to the over all radiation dose both to normal brain and to tumor. Simple algebraic summation cannot be applied to these dose components, since each component should at first be weighed by its relative biological effectiveness (RBE) value. Unfortunately, there is no worldwide agreement on these RBE values. For that reason, the parameters required for accurate planning of BNCT of brain tumors located at different depths in brain remained obscure. The most important of these parameters is; the source neutron energy. Thermal neutrons were formerly employed for BNCT, but they failed to prove therapeutic efficacy. Later on; epithermal neutrons were suggested proposing that they would be enough thermalized while transporting in the brain tissues. However; debate aroused regarding the source neutrons energy appropriate for treating brain tumors located at different depths in brain. Again, the insufficient knowledge regarding the RBE values of the different dose components was a major obstacle. A new concept was adopted for estimating the optimum source neutrons energy appropriate for different circumstances of BNCT. Four postulations on the optimum source neutrons energy were worked out, almost entirely independent of the RBE values of the different dose components. Four corresponding condition on the optimum source neutrons energy were deduced. An energy escalation study was carried out investigating 65 different source neutron energies, between 0.01 eV and 13.2 MeV. MCNP4B Monte C arlo neutron transport code was utilized to study the behavior of neutrons in the brain. The deduced four conditions were applied to the results of the 65 steps of the neutron energy escalation study. A source neutron energy range of few electron volts (eV) to about 30 keV was estimated to be the most appropriate for BNCT of brain tumors located at

  8. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    1990-01-01

    The Office of Energy Research sponsors long-term research in certain fundamental areas and in technical areas associated with energy resources, production, use, and resulting health and environmental effects. This document describes these activities, including recent accomplishments, types of facilities, and gives some impacts on energy, science, and scientific manpower development. The document is intended to respond to the many requests from diverse communities --- such as government, education, and public and private research --- for a summary of the types of research sponsored by the Department of Energy's Office of Energy Research. This is important since the Office relies to a considerable extent on unsolicited proposals from capable university and industrial groups, self-motivated interested individuals, and organizations that may wish to use the Department's extensive facilities and resources. By describing our activities and facilities, we hope not only to inform, but to also encourage interest and participation

  9. Human Research Program Science Management: Overview of Research and Development Activities

    Science.gov (United States)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

  10. Action Research: Effective Marketing Strategies for a Blended University Program

    Science.gov (United States)

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  11. IAEA Co-ordinated Research Program (CRP)

    International Nuclear Information System (INIS)

    Schrenk, M.

    2010-01-01

    The Coordinated Research Project is a topical collection of research agreements and contracts. The research contracts are awarded with financial support of about 10-20% of the total contract cost. Among the activities of the project is the organization of consultant group meetings and workshops involving several international experts and representatives of users and developers of border radiation monitoring equipment. The project also supports in coordinating the development of equipment and techniques for up-to-date border monitoring and in establishing of a process for providing nuclear forensics support to member states

  12. Management program on radioactive wastes in research

    International Nuclear Information System (INIS)

    Xavier, Ana Maria; Wieland, Patricia; Heilbron Filho, Paulo Fernando L.; Ferreira, Rubemar de Souza

    1998-01-01

    This document has the objective to orient and advise the researchers to practice a safety management of radioactive wastes in each research laboratory, based upon the technical norms of the Brazilian Nuclear Energy Commission and the recommendations of the International Atomic Energy Agency. Additionally, basic information on the main radioisotopes used in research are presented, including the processes used for production of radioisotopes, methods for radiation detection, range of alpha and beta particles, background radiation, as well as principles on radioprotection and biological effects of radiation

  13. Office of Naval Research Graduate Fellowship Program

    Science.gov (United States)

    1994-07-29

    fellowships coordinated their 1993 magazine advertisements. Each contractor advertised in four or five journals; and each contractor mentioned the other two... coordinated their 1993 magazine advertisements. Each contractor advertised in four or five journals; and each contractor mentioned the other two programs...Institute ONR Representative - A tIS𔃻O’ LIDA/ Sf(//I9 Computer Scien - Capital Room Ambrose Goicoechea, Statcom Robert Goldberg, Queens College

  14. USAF 1990 Research Initiation Program. Volume 3

    Science.gov (United States)

    1992-06-25

    components of the HVDC system and constant power load. The analysis using EMTP is included in this report. 48-2 Acknowledment I wish to thank the Air...motors can be used. The Electromagnetic Transients Program ( EMTP ), which was developed in the early seventies for Bonneville Power Administration...present should be undertaken. Since EMTP can be used to model various types of motors, it is possible to analyze the system under motor loads using EMTP

  15. A Research Program in Computer Technology

    Science.gov (United States)

    1979-01-01

    14 (7), 1971, 453-360. 5. Donzeau-Gouge, V., G. Kahn, and B. Lang , A Complete Machine-Checked Definition of a Simple Programming Language Using...Denotational Semantics, IRIA Laborla, Technical Report 330, October 1978. 6. Donzeau-Gouge, V., G. Kahn, and B. Lang , Formal Definition of Ada, Honeywell...May 1976. r S.-..-. . . . . . . . 12. ARPANET TENEX SERVICE T’fhttiral Staff Marion McKinley, Jr. William H. Moore Robert Hines Serge Poievitzky Edward

  16. Department of Defense Basic Research Program.

    Science.gov (United States)

    1980-08-01

    int lude the beha , spheric Administration-i.e., horizontal dimensions less ior of materials in the sea I(iorro.iosn and louling pollu than 200 km and...the sttuds oft ,ggregatio, (it voiluiii- orintrhereult wllenaletheprdi ito f seafloor sr at terig or gam sin, , mi the clist rbut ii n or beha % ii r...operated by ac ademic oceanographit institutions. deplovable. tleep-iit ian t0000t m) subsurtic e instrumen- the equipment -upgrade program to enhan t

  17. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2016-04-27

    Comments No complaints. Everything was really efficient. 18) PLEASE PROVIDE ANY SUGGESTIONS FOR PROGRAM IMPROVEMENT. Please do NOT scan to PDF . Send...Matthews, M., Klimko, C.P., Hill, A., Hunter, M., Bozue, J.A., Welkos, S.L., Cote, C.K. (2014) The impact of Bacillus anthracis and Bacillus ... thuringiensis spore germination state on potential secondary decontamination strategies, Journal of Applied Microbiology. 117, 1614-1633. b) Books, book

  18. Defense Coastal/Estuarine Research Program (DCERP)

    Science.gov (United States)

    2007-09-19

    actual human fecal contamination and non-human contamination. Stable isotope and pathogen analyses will allow some degree of source assessment...exciting candidate for an alternative indicator of fecal contamination. We will incorporate these tools into our sampling program for the NRE and use this...monitor nitrate isotopes (δ15N and δ18O) in a network of sampling stations dispersed through the subcatchments of the New River watershed. Stations will

  19. Embedding HIV Mentoring Programs in HIV Research Networks.

    Science.gov (United States)

    Fernández, M Isabel; Wheeler, Darrell P; Alfonso, Sarah V

    2016-09-01

    Responding to the demands of the HIV/AIDS epidemic necessitates a diverse scientific and clinical workforce trained in applying interdisciplinary research approaches to address the epidemic domestically and internationally. Ensuring diversity in our workforce requires concerted efforts. Yet, the majority of graduate and post-graduate programs are ill-equipped to provide this type of training. Research networks, the HPTN, HVTN, CFAR and ATN, are uniquely positioned to implement interdisciplinary mentoring programs and all four have done so. We describe these programs, the nuts and bolts of program implementation and efforts to recruit and retain diversity scholars. We outline some inherent challenges such as competing demands for network resources or tension in aligning scholars' research agenda with that of the networks. We argue that the benefits to be gained from continuing these programs far outweigh their costs and that these programs are an essential component of a comprehensive strategy for developing the future HIV research workforce.

  20. Anthropology and Educational Research: A Report on Federal Agency Programs

    Science.gov (United States)

    Ianni, Francis A. J.

    1976-01-01

    Summarizes and discusses a set of interviews with program specialists and managers conducted early in the spring of 1974 in several federal government agencies. These interviews attempted to determine the status of anthropology in educational research programs, to identify issues and problems concerning anthropology's role in educational research,…

  1. Assessment Study of an Undergraduate Research Training Abroad Program

    Science.gov (United States)

    Nieto-Fernandez, Fernando; Race, Kathryn; Quarless, Duncan A.

    2013-01-01

    The Old Westbury Neuroscience International Research Program (OWNIP) encourages undergraduate students from health disparities populations and underrepresented minorities to pursue careers in basic science, biomedical, clinical, and behavioral health research fields. To evaluate this program, several measures were used tracked through an online…

  2. Demonstration and Research Center for Early Education (DARCEE). Program Report.

    Science.gov (United States)

    Far West Lab. for Educational Research and Development, Berkeley, CA.

    This document is the first in a series of 12 early childhood program descriptions compiled by the Far West Laboratory for Educational Research and Development. The program described here is the Demonstration and Research Center for Early Education (DARCEE) which was established at the George Peabody College for Teachers in Nashville, Tennessee, in…

  3. 30 CFR 402.6 - Water-Resources Research Program.

    Science.gov (United States)

    2010-07-01

    ... hydrologic cycle; (2) Supply and demand for water; (3) Demineralization of saline and other impaired waters... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM...

  4. Western hardwoods : value-added research and demonstration program

    Science.gov (United States)

    D. W. Green; W. W. Von Segen; S. A. Willits

    1995-01-01

    Research results from the value-added research and demonstration program for western hardwoods are summarized in this report. The intent of the program was to enhance the economy of the Pacific Northwest by helping local communities and forest industries produce wood products more efficiently. Emphasis was given to value-added products and barriers to increased...

  5. A research Program in Elementary Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Sobel, Henry; Molzon, William; Lankford, Andrew; Taffard, Anyes; Whiteson, Daniel; Kirkby, David

    2013-07-25

    Work is reported in: Neutrino Physics, Cosmic Rays and Elementary Particles; Particle Physics and Charged Lepton Flavor Violation; Research in Collider Physics; Dark Energy Studies with BOSS and LSST.

  6. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2015-05-01

    and USMA Mentor, if applicable) Soft Tissue Regeneration Lab Christopher Rathbone 6) TITLE OF RESEARCH PROPOSAL Composite pre-vascularized scaffolds...Mende K, Beckius ML, Akers KS, Wenke JC, and Murray CK.ln Vitro Toxicity and Activity of Medical Grade Honey on Filamentous Fungi and Human Cells...PATENTOR COPYRIGHT APPLICATIONS RESULTING FROM NRC ASSOCIATESHIP RESEARCH Provide titles, inventors, and dates of applications. Composition with

  7. Research Awards: Agriculture and Food Security program Deadline ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    2012-09-12

    Sep 12, 2012 ... IDRC's Research Awards are a unique opportunity for master's and doctoral-level students, as well as recent graduates to enhance their research skills and gain a fresh perspective on crucial development issues. This one-year, paid in-house program of training and mentorship in research, research ...

  8. Research and development program in reactor safety for NUCLEBRAS

    International Nuclear Information System (INIS)

    Pinheiro, R.B.; Resende Lobo, A.A. de; Horta, J.A.L.; Avelar Esteves, F. de; Lepecki, W.P.S.; Mohr, K.; Selvatici, E.

    1984-01-01

    With technical assistance from the IAEA, it was established recently an analytical and experimental Research and Development Program for NUCLEBRAS in the area of reactor safety. The main objectives of this program is to make possible, with low investments, the active participation of NUCLEBRAS in international PWR safety research. The analytical and experimental activities of the program are described with some detail, and the main results achieved up to now are presented. (Author) [pt

  9. SKB's program for societal research 2004-2011. An evaluation

    International Nuclear Information System (INIS)

    Soederberg, Olof

    2012-04-01

    This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?

  10. Biodistribution of a new boron compound for BNCT in an experimental model of oral cancer

    International Nuclear Information System (INIS)

    Kreimann, Erica L.; Itoiz, Maria E.; Schwint, Amanda E.; Miura, M.; Coderre, J.A.; Garavaglia, Ricardo; Batistoni, Daniel A.

    2000-01-01

    We have proposed and validated the HCP carcinogenesis model of oral cancer, a model that mimics spontaneous malignant transformation, for BNCT research in a separate study. We herein perform a biodistribution study of a lipophilic carborane-containing tetraphenylporphyrin, CuTCPH, in this model. This compound was previously tested in a model of mice bearing subcutaneously transplanted mammary carcinomas. In the present study CuTCPH was administered as a single i.p. injection at a dose of 32 μg/g b.w. (10 μg B/g b.w.) or as 4 i.p. injections over 2 days at a dose of 32 μg/g b.w. per injection. Blood (Bl) and tissue, i.e. tumor (T), precancerous tissue surrounding tumor (P), normal pouch (N), skin, tongue, cheek and palate mucosa, liver, spleen, parotid gland and brain were sampled 3, 6, 12, 24, 48 and 72 hs post-administration in the single dose protocol and 1-4 days after the last injection in the multidose protocol. Boron (B) analysis was performed by ICP-AES. The maximum ratio of B concentration for the single dose protocol was 32.7:1 for T:N and 31.8:1 for T:Bl. The B value in tumor reached a maximum of 43.8 ppm. However, the mean value of 16 ± 14.3 ppm fell short of therapeutically useful levels. The multidose protocol yielded maximum ratios of 53.33:1 for T:N and 3633.3:1 for T:Bl. The maximum absolute B value in tumor reached 106.40 ppm. The mean value in tumor 3 days post-administration was 68.02 ± 25.02. Absolute and relative maximum and average B values markedly exceeded the therapeutic threshold values. (author)

  11. A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba

    Energy Technology Data Exchange (ETDEWEB)

    Aiyama, H. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Nakai, K., E-mail: knakai@Neurosurg-tsukuba.com [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Yamamoto, T. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan)] [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Nariai, T. [Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyouku (Japan); Kumada, H. [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Ishikawa, E. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Isobe, T. [Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan); Endo, K.; Takada, T.; Yoshida, F.; Shibata, Y.; Matsumura, A. [Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba (Japan)

    2011-12-15

    We have evaluated the efficacy and safety of boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor using a new protocol. One of the two patients enrolled in this trial is a man with recurrent glioblastoma and the other is a woman with anaplastic meningioma. Both are still alive and no severe adverse events have been observed. Our findings suggest that NCT will be safe as a palliative therapy for malignant brain tumors. - Highlights: Black-Right-Pointing-Pointer Boron neutron capture therapy (BNCT) for recurrent glioma and malignant brain tumor. Black-Right-Pointing-Pointer Two cases with recurrent glioblastoma and anaplastic meningioma. Black-Right-Pointing-Pointer No severe adverse events have been observed using BNCT. Black-Right-Pointing-Pointer BNCT has a possibility of a safe palliative therapy for malignant brain tumors.

  12. Acceptable respiratory protection program and LASL respirator research

    Energy Technology Data Exchange (ETDEWEB)

    Skaggs, B.J.

    1979-01-01

    A short history is presented on the LASL Respiratory Protection Training Programs. Then a discussion is given on the major points of an acceptable respiratory protection program utilizing the points required by the Occupational, Safety, and Health Administration (OSHA) Regulation 29 CFR 1910.134. Contributions to respirator research are reviewed. Discussion is presented under the following section headings: program administration; respirator selection; respirator use; fitting and training; respirator maintenance; medical clearance and surveillance; special problems; program evaluation; and documentation (records).

  13. Acceptable respiratory protection program and LASL respirator research

    International Nuclear Information System (INIS)

    Skaggs, B.J.

    1979-01-01

    A short history is presented on the LASL Respiratory Protection Training Programs. Then a discussion is given on the major points of an acceptable respiratory protection program utilizing the points required by the Occupational, Safety, and Health Administration (OSHA) Regulation 29 CFR 1910.134. Contributions to respirator research are reviewed. Discussion is presented under the following section headings: program administration; respirator selection; respirator use; fitting and training; respirator maintenance; medical clearance and surveillance; special problems; program evaluation; and documentation

  14. Army Medical Research and Materiel Command Resident Research Associateship Program

    Science.gov (United States)

    2017-05-01

    Neurobehavioral Effectiveness during Chronic Sleep Restriction and Total Sleep Deprivation Adviser: Capaldi, Vincent F Research Proposal: ADORA2A SNP...Ehlen JC, Esser KA, Paul KN, Novak CM, 2017, Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal...loss of consciousness, gait, and cognitive and affective behaviors were performed. Fludeoxyglucose (FDG) Positron Emission Tomography ( PET ) experiments

  15. Laboratory Directed Research and Development Program: FY 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    SLAC,

    2016-04-04

    The Department of Energy (DOE) and the SLAC National Accelerator Laboratory (SLAC) encourage innovation, creativity, originality and quality to maintain the Laboratory’s research activities and staff at the forefront of science and technology. To further advance its scientific research capabilities, the Laboratory allocates a portion of its funds for the Laboratory Directed Research and Development (LDRD) program. With DOE guidance, the LDRD program enables SLAC scientists to make rapid and significant contributions that seed new strategies for solving important national science and technology problems. The LDRD program is conducted using existing research facilities.

  16. Exploratory Technology Research Program for electrochemical energy storage

    Science.gov (United States)

    Kinoshita, Kim

    1994-09-01

    The U.S. Department of Energy's Office of Propulsion Systems provides support for an Electrochemical Energy Storage Program, that includes research and development (R&D) on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles (EV's). The program centers on advanced systems that offer the potential for high performance and low life-cycle costs, both of which are necessary to permit significant penetration into commercial markets. The DOE Electrochemical Energy Storage Program is divided into two projects: the Electric Vehicle Advanced Battery Systems (EVABS) Development Program and the Exploratory Technology Research (ETR) Program. The EVABS Program management responsibility has been assigned to Sandia National Laboratories (SNL); Lawrence Berkeley Laboratory (LBL) is responsible for management of the ETR Program. The EVABS and ETR Programs include an integrated matrix of R&D efforts designed to advance progress on selected candidate electrochemical systems. The United States Advanced Battery Consortium (USABC), a tripartite undertaking between DOE, the U.S. automobile manufacturers and the Electric Power Research Institute (EPRI), was formed in 1991 to accelerate the development of advanced batteries for consumer EV's. The role of the FIR Program is to perform supporting research on the advanced battery systems under development by the USABC and EVABS Program, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the ETR Program is to identify the most promising electrochemical technologies and transfer them to the USABC, the battery industry and/or the EVABS Program for further development and scale-up. This report summarizes the research, financial and management activities relevant to the ETR Program in CY 1993.

  17. Cross talk experiment with two-element CdTe detector and collimator for BNCT-SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Manabe, Masanobu; Ohya, Ryosuke; Saraue, Nobuhide; Sato, Fuminobu; Murata, Isao [Osaka University, Osaka (Japan)

    2016-12-15

    Boron Neutron Capture Therapy (BNCT) is a new radiation therapy. In BNCT, there exists some very critical problems that should be solved. One of the severest problems is that the treatment effect cannot be known during BNCT in real time. We are now developing a SPECT (single photon emission computed tomography) system (BNCT-SPECT), with a cadmium telluride (CdTe) semiconductor detector. BNCT-SPECT can obtain the BNCT treatment effect by measuring 478 keV gamma-rays emitted from the excited state of 7Li nucleus created by 10B(n,α) 7Li reaction. In the previous studies, we investigated the feasibility of the BNCT-SPECT system. As a result, the S/N ratio did not meet the criterion of S/N >1 because deterioration of the S/N ratio occurred caused by the influence of Compton scattering especially due to capture gamma-rays of hydrogen. We thus produced an arrayed detector with two CdTe crystals to test cross talk phenomenon and to examine an anti-coincidence detection possibility. For more precise analysis for the anti-coincidence detection, we designed and made a collimator having a similar performance to the real BNCT-SPECT. We carried out experiments with the collimator to examine the effect of cross talk of scattering gamma-rays between CdTe elements more practically. As a result of measurement the coincidence events were successfully extracted. We are now planning to carry out evaluation of coincidence rate from the measurement and comparison of it with the numerical calculations.

  18. Building Innovation and Sustainability in Programs of Research.

    Science.gov (United States)

    Villarruel, Antonia M

    2018-01-01

    Innovation and sustainability are two important concepts of impactful programs of research. While at first glance these concepts and approaches may seem at odds, they are synergistic. We examine the social, political, and policy context as it relates to innovation and sustainability. We present an exemplar of a program of research and discuss factors to consider in developing innovative and sustainable programs of research. Innovation is an important component of sustainable programs of research. Understanding the social and political context and addressing relevant policy issues are factors to be considered in both innovation and sustainability. Innovation and sustainability, important components of research, are also central to clinical practice. Open communication between researchers and clinicians can support the acceleration of innovations and the integration of evidence-based findings in practice. © 2017 Sigma Theta Tau International.

  19. The southern plains LTAR watershed research program

    Science.gov (United States)

    Patrick Starks; Jean L. Steiner

    2016-01-01

    Water connects physical, biological, chemical, ecological, and economic forces across the landscape. While hydrologic processes and scientific investigations related to sustainable agricultural systems are based on universal principles, research to understand processes and evaluate management practices is often site-specific in order to achieve a critical mass of...

  20. Research Program in Tropical Infectious Diseases

    Science.gov (United States)

    1992-12-01

    patterns of drug resistance of Neisseria gonorrhea in various regions. 4. Determine patterns of malaria transmission; maintain surveillance for chloroquine... therapy . It occurs in both the New and Old Worlds. Serious illness with leishmaniasis has been reported as a manifestation of HIV infection. The...words) Research progressed in fevers of unknown origin, leishmaniasis and mosquito larval ecology. New initiatives included investigations of hepatitis

  1. Research Award: Agriculture and Food Security Program

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    strategies for youth engagement in agri-food value chains for improved food security. The research will help to develop a practical framework for identifying and ... and food security, have a clear commitment to AFS' methodological building blocks. (e.g., multistakeholder participation, transdisciplinary approaches), and ...

  2. Research Awards: Canadian Partnerships Program Deadline: 12 ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Jean-Claude Dumais

    2012-09-12

    Sep 12, 2012 ... This award provides young and upcoming professionals with a unique opportunity to strengthen their research skills and gain a fresh perspective on the Canadian community – both in universities and civil society organizations (CSOs) – that is actively engaged in creating, sharing, and using knowledge to ...

  3. The AFT Educational Research and Dissemination Program

    Science.gov (United States)

    American Federation of Teachers, 2007

    2007-01-01

    This brochure is developed to provide information for local unions within the American Federation of Teachers (AFT) who may be interested in becoming Education Research and Dissemination (ER&D) sites. The following questions are addressed: (1) What Is ER&D? (2) What Can ER&D Accomplish? (3) What Makes ER&D Different? (4) What Do ER&D Participants…

  4. NASA Hydrogen Research at Florida Universities, Program Year 2003

    Science.gov (United States)

    Block, David L.; Raissi, Ali

    2006-01-01

    This document presents the final report for the NASA Hydrogen Research at Florida Universities project for program year 2003. This multiyear hydrogen research program has positioned Florida to become a major player in future NASA space and space launch projects. The program is funded by grants from NASA Glenn Research Center with the objective of supporting NASA's hydrogen-related space, space launch and aeronautical research activities. The program conducts over 40 individual projects covering the areas of cryogenics, storage, production, sensors, fuel cells, power and education. At the agency side, this program is managed by NASA Glenn Research Center and at the university side, co-managed by FSEC and the University of Florida with research being conducted by FSEC and seven Florida universities: Florida International University, Florida State University, Florida A&M University, University of Central Florida, University of South Florida, University of West Florida and University of Florida. For detailed information, see the documents section of www.hydrogenresearch.org. This program has teamed these universities with the nation's premier space research center, NASA Glenn, and the nation's premier space launch facility, NASA Kennedy Space Center. It should be noted that the NASA Hydrogen Research at Florida Universities program has provided a shining example and a conduit for seven Florida universities within the SUS to work collaboratively to address a major problem of national interest, hydrogen energy and the future of energy supply in the U.S.

  5. USAF Summer Faculty Research Program. 1981 Research Reports. Volume II.

    Science.gov (United States)

    1981-10-01

    aureus infection is poorly understood but the serious, systemic manifestations of a local (vaginal) infection suggest that a toxin or toxins are...bacterial pathogen study. Much research has been done on the genetics of S. aureus plasmids, especially as they relate to the host’s toxin production...Admix- ture," Anal. Chem. ACTA., Vol. 35, pages 330-336, (1966). 2. L.A. Dee, "Gas Chromatographic Determination of Agueous Trace Hydra - zine and

  6. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  7. Computer Presentation Programs and Teaching Research Methodologies

    Directory of Open Access Journals (Sweden)

    Vahid Motamedi

    2015-05-01

    Full Text Available Supplementing traditional chalk and board instruction with computer delivery has been viewed positively by students who have reported increased understanding and more interaction with the instructor when computer presentations are used in the classroom. Some problems contributing to student errors while taking class notes might be transcription of numbers to the board, and handwriting of the instructor can be resolved in careful construction of computer presentations. The use of computer presentation programs promises to increase the effectiveness of learning by making content more readily available, by reducing the cost and effort of producing quality content, and by allowing content to be more easily shared. This paper describes how problems can be overcome by using presentation packages for instruction.

  8. Prediction of boron concentration in blood from low dose infusion for the patients of BNCT at JAERI

    International Nuclear Information System (INIS)

    Shibata, Y.; Matsumura, A.; Yamamoto, T.

    2000-01-01

    It is difficult to measure boron concentration in blood during neutron irradiation in BNCT. We have investigated the predictability of boron concentration in blood from the data at 1st craniotomy after low dose BSH infusion. Two patients entered BNCT at JRR2 in 1995/1996, and 5 patients entered BNCT at JRR4 in 1992/2000. The patients include 2 male and 5 female and their age ranged from 20 to 66. In 5 patients 1 g of BSH was infused before 1st tumor removal operation and boron concentrations in blood were examined around this operation. All patients were infused 100 mg/kg of BSH at 12 hours prior to BNCT and boron concentrations were examined before and after BNCT using prompt gamma ray analysis or ICP-AES. Each results showed biphasic pharmacokinetic profile. Personal variations of the pharmacokinetics of BSH were small. Final and 1 g data were well correlated and final boron concentrations at BNCT were predictable from 1 g studies. (author)

  9. Prediction of boron concentration in blood from low dose infusion for the patients of BNCT at JAERI

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Y.; Matsumura, A.; Yamamoto, T. [University of Tsukuba, Department of Neurosurgery, Tsukuba, Ibaraki (JP)] [and others

    2000-10-01

    It is difficult to measure boron concentration in blood during neutron irradiation in BNCT. We have investigated the predictability of boron concentration in blood from the data at 1st craniotomy after low dose BSH infusion. Two patients entered BNCT at JRR2 in 1995/1996, and 5 patients entered BNCT at JRR4 in 1992/2000. The patients include 2 male and 5 female and their age ranged from 20 to 66. In 5 patients 1 g of BSH was infused before 1st tumor removal operation and boron concentrations in blood were examined around this operation. All patients were infused 100 mg/kg of BSH at 12 hours prior to BNCT and boron concentrations were examined before and after BNCT using prompt gamma ray analysis or ICP-AES. Each results showed biphasic pharmacokinetic profile. Personal variations of the pharmacokinetics of BSH were small. Final and 1 g data were well correlated and final boron concentrations at BNCT were predictable from 1 g studies. (author)

  10. Possible research program on a large scale nuclear pressure vessel

    International Nuclear Information System (INIS)

    1983-01-01

    The nuclear pressure vessel structural integrity is actually one of the main items in the nuclear plants safety field. An international study group aimed at investigating the feasibility of a ''possible research program'' on a scale 1:1 LWR pressure vessel. This report presents the study group's work. The different research programs carried out or being carried out in various countries of the European Community are presented (phase I of the study). The main characteristics of the vessel considered for the program and an evaluation of activities required for making them available are listed. Research topic priorities from the different interested countries are summarized in tables (phase 2); a critical review by the study group of the topic is presented. Then, proposals for possible experimental programs and combination of these programs are presented, only as examples of possible useful research activities. The documents pertaining to the results of phase I inquiry performed by the study group are reported in the appendix

  11. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Maxwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1990-02-01

    This report summarizes three documents: Multiyear Research Plan, Volume I FY 1989 Task Reports, and Volume II Appendices. These documents describe tasks that were undertaken from November 1988 to December 1989, the first year of the project. Those tasks were: (1) the formation of a steering committee, (2) the development of a multiyear research plan, (3) analysis of the US industrialized housing industry, (4) assessment of foreign technology, (5) assessment of industrial applications, (6) analysis of computerized design and evaluation tools, and (7) assessment of energy performance of baseline and advanced industrialized housing concepts. While this document summarizes information developed in each task area, it doesn't review task by task, as Volume I FY 1989 Task Reports does, but rather treats the subject of energy efficient industrialized housing as a whole to give the reader a more coherent view. 7 figs., 9 refs.

  12. Coconut Program Area Research Planning and Prioritization

    OpenAIRE

    Aragon, Corazon

    2000-01-01

    The coconut industry is one of the country's major pillars in employment generation and foreign exchange earnings. However, local production problems, the expansion in coconut hectarage of neighboring countries, and recent developments in biotechnology research on other competing crops that have high lauric oil content might affect its long-term sustainability and viability. In a highly liberalized global trade environment, innovation and creativity in the country's coconut industry are neede...

  13. Therapeutic efficacy and toxicity of a single and double application of boron neutron capture therapy (BNCT) in a hamster cheek pouch oral precancer model

    International Nuclear Information System (INIS)

    Monti Hughes, A; Pozzi, E C C; Thorp, S; Garabalino, M A; Farias, R O; Gonzalez, S J; Heber, E M; Itoiz, M E; Aromando, R F; Molinari, A J; Miller, M; Nigg, D W; Curotto, P; Trivillin, V A; Schwint, A E

    2012-01-01

    Tumor development from tissue with potentially malignant disorders (PMD) gives rise to second primary tumors. We previously demonstrated the partial inhibitory effect on tumor development of Boron Neutron Capture Therapy (BNCT) mediated by the boron compounds BPA (boronophenylalanine) and decahydrodecaborate (GB-10) in a hamster pouch oral precancer model. Seeking to optimize BNCT, the aim of the present study was to contribute to the knowledge of BNCT radiobiology for oral precancer and assess new BNCT protocols in terms of inhibition of tumor development and radiotoxicity. Groups of cancerized hamsters were locally exposed to single or double applications (2 weeks apart) of BPA-BNCT or (GB-10 + BPA)-BNCT at a total dose of 8Gy to tissue with PMD; to a single application of BPA-BNCT at 6Gy and to a double application (4 weeks apart) of BPA-BNCT or (BPA + GB-10)-BNCT at a total dose of 10Gy. Cancerized, sham-irradiated hamsters served as controls. Clinical status, tumor development from tissue with PMD and mucositis were followed for 8 months. The marked therapeutic efficacy of single applications of BNCT at 6 and 8Gy were associated to severe radiotoxicity. Dose fractionation into 2 applications reduced mucositis but also reduced therapeutic efficacy, depending on dose and interval between applications. A double application (4 weeks apart) of (GB-10 + BPA)-BNCT at a total dose of 10Gy rendered the best therapeutic advantage, i.e. 63% - 100% inhibition of tumor development with only slight mucositis in 67% of cases. The data reported herein show that issues such as dose levels and dose fractionation, interval between applications, and choice of boron compounds are pivotal to therapeutic advantage and must be tailored for a particular pathology and anatomic site. The present study determined treatment conditions that would contribute to optimize BNCT for precancer and that would warrant cautious assessment in a clinical scenario (author)

  14. Research program in elementary particle theory

    International Nuclear Information System (INIS)

    Balachandran, A.P.; Rosenzweig, C.; Schechter, J.; Wali, K.C.

    1990-01-01

    Discussed in this paper is a brief account of the research work of the principal investigators and their co-workers during the past few years. The topics covered include: Topology in Physics; Skyrme Model; High Temperature Superconductivity; fractional statistics, and generalized spin statistics theorem; QCD as a dual chromomagnetic superconductor; confinement and string picture in QCD; quark gluon plasmas; cosmic strings; effective Lagrangians for QCD; ''proton spin,'' ''strange content'' and related topics; physical basis of the Skyrme model; gauge theories and weak interactions; grand unification; Universal ''see saw mechanism''; abelian and non-abelian interactions of a test string

  15. NRC/AMRMC Resident Research Associateship Program

    Science.gov (United States)

    2013-05-01

    restored homeostasis ). Vecchi, Vittoria 11114t2011-10t22t2042 1 ; Effectö of ra¿¡áiiôn dose reduction on lung quantitative CT öcan reðults in healthy...with minimal training Ín infectious disease, tenure with NRC has encouraged me to continue in infectious disease ecology and bioinformatic analysis. It...hemodynamics and coagulation response (restored homeostasis ). (USMA Davies Fellow: please add summâry of teaching, including classes taught.) 8) RESEARCH IN

  16. Recent highlights of the PALS research program

    Czech Academy of Sciences Publication Activity Database

    Jungwirth, Karel

    2005-01-01

    Roč. 23, - (2005), s. 177-182 ISSN 0263-0346. [ECLIM 2004: European Conference on Laser Interaction with Matter /28./. Roma, 06.09.2004-10.09.2004] R&D Projects: GA AV ČR(CZ) KSK2043105; GA MŠk(CZ) LN00A100 Grant - others:European Commission(XE) HPRI-CT-1999-00053 Institutional research plan: CEZ:AV0Z10100523 Keywords : ablation * Iodine lasers * laser ion sources * laser-produced plasma * laser-target interaction * PALS * shock waves * XUV lasers Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.590, year: 2005

  17. Research program with no ''measurement problem''

    International Nuclear Information System (INIS)

    Noyes, H.P.; Gefwert, C.; Manthey, M.J.

    1985-07-01

    The ''measurement problem'' of contemporary physics is met by recognizing that the physicist participates when constructing and when applying the theory consisting of the formulated formal and measurement criteria (the expressions and rules) providing the necessary conditions which allow him to compute and measure facts, yet retains objectivity by requiring that these criteria, rules and facts be in corroborative equilibrium. We construct the particulate states of quantum physics by a recursive program which incorporates the non-determinism born of communication between asynchronous processes over a shared memory. Their quantum numbers and coupling constants arise from the construction via the unique 4-level combinatorial hierarchy. The construction defines indivisible quantum events with the requisite supraluminal correlations, yet does not allow supraluminal communication. Measurement criteria incorporate c, h-bar, and m/sub p/ or (not ''and'') G. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact

  18. Research program on plasma core assembly

    International Nuclear Information System (INIS)

    Bernard, W.; Helmick, H.H.; Jarvis, G.A.; Plassmann, E.A.; White, R.H.

    1975-05-01

    An operating critical assembly having a 1.024-m-diam by 1.055-m-high cavity reflected by 0.48 m of beryllium has been constructed of residual beryllium reflector segments, control drums, drive motors, and control console from the solid core nuclear rocket development program. The critical mass for uranium distributed throughout the cavity is 16.9 kg U(93.2), which is high because of neutron undermoderation in the reflector due to porosity and poison contaminants in the beryllium and graphite reflector components. A flux trapping beryllium annulus, 0.546-m-i.d. by 0.89-m-o.d., centered in the cavity, reduced the critical mass to 6.7 kg U(93.2). This arrangement will permit operation with a UF 6 zone inside the flux trap driven by an outer uranium-graphite fuel zone. The fission density inside the flux trap is appreciably higher than in the outer fuel zone. (U.S.)

  19. AECL's research and development program in environmental science and technology

    International Nuclear Information System (INIS)

    Cornett, R.J.

    1998-07-01

    AECL's radiological research and development (R and D) program encompasses work on sources of radiation exposure, radionuclide transport through the environment and potential impacts on biota and on human health. The application of the radiation protection knowledge and technology developed in this program provides cradle-to-grave management for CANDU and related nuclear technologies. This document provides an overview of the Environmental Science and Technology (ES and T) program which is one of the technical areas of R and D within the radiological R and D program. The ES and T program uses science from three main areas: radiochemistry, mathematical modelling and environmental assessment. In addition to providing an overview of the program, this summary also gives specific examples of recent technical work in each of the three areas. These technical examples illustrate the applied nature of the ES and T program and the close coupling of the program to CANDU customer requirements. (author)

  20. The Atomic Energy Control Board's regulatory research and support program

    International Nuclear Information System (INIS)

    1988-04-01

    The purpose of the Regulatory Research and Support Program is to augment and extend the capability of the Atomic Energy Control Board's (AECB) regulatory program beyond the capability of in-house resources. The overall objective of the program is to produce pertinent and independent scientific and other knowledge and expertise that will assist the AECB in making correct, timely and credible decisions on regulating the development, application and use of atomic energy. The objectives are achieved through contracted research, development, studies, consultant and other kinds of projects administered by the Research and Radiation Protection Branch (RRB) of the AECB

  1. DFID-IDRC Global Adaptation Research Program | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Global Adaptation Research Program (now known as the Collaborative Adaptation Research Initiative in Africa and Asia or CARIAA) is a new partnership ... Using different socio-economic scenarios and climate warming scenarios, researchers will develop a better understanding of the conditions that make poor people ...

  2. Human genome program report. Part 2, 1996 research abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  3. Action Research in EdD Programs in Educational Leadership

    Science.gov (United States)

    Osterman, Karen; Furman, Gail; Sernak, Kathleen

    2014-01-01

    This exploratory study gathered information about the use of action research within doctor of education programs in educational leadership and explored faculty understanding of and perspectives on action research. Survey data established that action research is used infrequently to meet dissertation requirements. Contributing factors include lack…

  4. American research programs on controlled thermonuclear fusion

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    At a time when the site of the European JET project has been decided, this study proposes to highlight the American effort in this field over the last five years. The Federal Civil Research and Development budget assigned to Energy has been multiplied by 6.3 and inside this budget the portion allocated to fusion has been multiplied by a factor of 6, in value. Two avenues have been explored; magnetic confinement and inertial confinement but one reaction only has been considered, namely D + T fusion. In magnetic confinement, the first operational reactor is being contemplated for around the year 2012. Three technologies have been explored in inertial confinement: by laser beams, electron beams and ion beams [fr

  5. Hydrogen fuelled buses: Italian ENEA research program

    International Nuclear Information System (INIS)

    Ambrosini, G.; Ciancia, A.; Pede, G.

    1993-01-01

    Current hydrogen automotive fuels research studies being conducted by ENEA (Italian Agency for New Technology, Energy and the Environment) are being targeted towards the development of hydrogen fueled vans and buses for use in highly polluted urban environments where the innovative vehicles' air pollution abatement characteristics would justify their high operating costs as compared with those of conventional automotive alternatives. The demonstration vehicle being used in the experimental studies and performance tests is a two liter minibus with a spark ignition engine power rated at 55 kW with gasoline operation and 45 kW with hydrogen. Detailed design notes are given regarding the retrofitting of the minibus chassis to house the aluminium gas storage tanks and the adaptation of the engine to operate with compressed hydrogen. Attention is given to efforts being made to resolve combustion control and fueling problems. Focus is on the progress being made in the development of an efficient and safe electronically controlled fuel injection system

  6. Sandia Combustion Research Program: Annual report, 1986

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This report presents research results of the past year, divided thematically into some ten categories. Publications and presentations arising from this work are included in the appendix. Our highlighted accomplishment of the year is the announcement of the discovery and demonstration of the RAPRENOx process. This new mechanism for the elimination of nitrogen oxides from essentially all kinds of combustion exhausts shows promise for commercialization, and may eventually make a significant contribution to our nation's ability to control smog and acid rain. The sections of this volume describe the facility's laser and computer system, laser diagnostics of flames, combustion chemistry, reacting flows, liquid and solid propellant combustion, mathematical models of combustion, high-temperature material interfaces, studies of engine/furnace combustion, coal combustion, and the means of encouraging technology transfer. 182 refs., 170 figs., 12 tabs.

  7. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Mazwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1989-12-01

    This document describes the research work completed in five areas in fiscal year 1989. (1) The analysis of the US industrialized housing industry includes statistics, definitions, a case study, and a code analysis. (2) The assessment of foreign technology reviews the current status of design, manufacturing, marketing, and installation of industrialized housing primarily in Sweden and Japan. (3) Assessment of industrialization applications reviews housing production by climate zone, has a cost and energy comparison of Swedish and US housing, and discusses future manufacturing processes and emerging components. (4) The state of computer use in the industry is described and a prototype design tool is discussed. (5) Side by side testing of industrialized housing systems is discussed.

  8. Summer Research Program - 1998 High School Apprenticeship Program Final Reports. Volume 12, Armstrong Laboratory

    National Research Council Canada - National Science Library

    Moore, Gary

    1998-01-01

    The United States Air Force Summer Research Program (USAF-SRP) is designed to introduce university, college, and technical institute faculty members, graduate students, and high school students to Air Force research...

  9. Summer Research Program - 1998 High School Apprenticeship Program Volume 13 Rome Laboratory

    National Research Council Canada - National Science Library

    Moore, Gary

    1998-01-01

    The United States Air Force Summer Research Program (USAF-SRP) is designed to introduce university, college, and technical institute faculty members, graduate students, and high school students to Air Force research...

  10. Department of Energy - Office of Science Early Career Research Program

    Science.gov (United States)

    Horwitz, James

    The Department of Energy (DOE) Office of Science Early Career Program began in FY 2010. The program objectives are to support the development of individual research programs of outstanding scientists early in their careers and to stimulate research careers in the disciplines supported by the DOE Office of Science. Both university and DOE national laboratory early career scientists are eligible. Applicants must be within 10 years of receiving their PhD. For universities, the PI must be an untenured Assistant Professor or Associate Professor on the tenure track. DOE laboratory applicants must be full time, non-postdoctoral employee. University awards are at least 150,000 per year for 5 years for summer salary and expenses. DOE laboratory awards are at least 500,000 per year for 5 years for full annual salary and expenses. The Program is managed by the Office of the Deputy Director for Science Programs and supports research in the following Offices: Advanced Scientific and Computing Research, Biological and Environmental Research, Basic Energy Sciences, Fusion Energy Sciences, High Energy Physics, and Nuclear Physics. A new Funding Opportunity Announcement is issued each year with detailed description on the topical areas encouraged for early career proposals. Preproposals are required. This talk will introduce the DOE Office of Science Early Career Research program and describe opportunities for research relevant to the condensed matter physics community. http://science.energy.gov/early-career/

  11. Carbon dioxide effects research and assessment program

    International Nuclear Information System (INIS)

    Jacoby, G.

    1980-12-01

    Information about the past and present concentrations of CO 2 in the atmosphere and variations in climate can be obtained from measurements of stable isotopes in tree rings; specifically carbon-13, oxygen-18 and deuterium. The analysis of these stable isotopes in tree rings is a relatively new and rapidly developing field. This proceedings volume contains most of the papers presented at the meeting. The first paper gives an overview of the status of carbon-13 research. Papers relating to carbon-13 are in section I and grouped separately from the contributions on carbon-14. Although the meeting was primarily concerned with stable isotopes, all carbon isotopic analysis may be helpful in understanding the carbon-13 record in tree rings. The papers on hydrogen and oxygen isotope studies are in sections II and III respectively. The remaining sections contain papers that consider more than one isotope at a time, general topics related to isotopes, atmospheric changes and tree growth, and methods of isotopic analysis

  12. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  13. Maryland magnetic fusion research program: MS speromak

    International Nuclear Information System (INIS)

    DeSilva, A.W.; Goldenbaum, G.C.; Griem, H.R.

    1989-07-01

    The main theme of our present experimentation on MS is to prolong the spheromak lifetime. This research has been concerned with such topics as passive MHD stabilization coils, impurity control and increased energy storage. At the present time the longest lived plasmas appear to be line tied to the liner or reversal coils. The natural consequence of having net flux outside the separatrix and a resistive plasma is that the plasma shrinks in time. At some point in time the plasma is far enough from the liner, or stabilization coils, that it becomes unstable. If we increase the bias field so as to move the separatrix further inside the liner, the plasma becomes unstable earlier as the separatrix moves to a smaller radius in a shorter time than if it starts out outside the liner. We have tried to circumvent this behavior with various configurations of passive conductors used as stabilizing elements. In this paper, we detail some of the machine modifications that have been tried in attempts to produce a stable, long-lived plasma

  14. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium

  15. Clean coal technologies: Research, development, and demonstration program plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The US Department of Energy, Office of Fossil Energy, has structured an integrated program for research, development, and demonstration of clean coal technologies that will enable the nation to use its plentiful domestic coal resources while meeting environmental quality requirements. The program provides the basis for making coal a low-cost, environmentally sound energy choice for electric power generation and fuels production. These programs are briefly described.

  16. AGING WATER INFRASTRUCTURE RESEARCH PROGRAM: ADDRESSING THE CHALLENGE THROUGH INNOVATION

    Science.gov (United States)

    A driving force behind the Sustainable Water Infrastructure (SI) initiative and the Aging Water Infrastructure (AWI) research program is the Clean Water and Drinking Water Infrastructure Gap Analysis. In this report, EPA estimated that if operation, maintenance, and capital inves...

  17. Northeast Cooperative Research Study Fleet (SF) Program Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Northeast Cooperative Research Study Fleet (SF) Program partners with a subset of commercial fishermen to collect high quality, high resolution, haul by haul...

  18. Research Breathes New Life Into Senior Travel Program.

    Science.gov (United States)

    Blazey, Michael

    1986-01-01

    A survey of older citizens concerning travel interests revealed constraints to participation in a travel program. A description is given of how research on attitudes and life styles indicated ways in which these constraints could be lessened. (JD)

  19. 78 FR 11745 - Small Business Size Regulations, Small Business Innovation Research (SBIR) Program and Small...

    Science.gov (United States)

    2013-02-20

    ..., Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR) Program... Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. DATES: Effective February...

  20. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  1. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Ronald C.

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described. (MOW)

  2. Research Capacity Peer Mentorship Program: Case Study on the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Research Capacity Peer Mentorship Program: Case Study on the ICT and Development Conference. The Fifth International Conference on Information and Communication Technologies and ... Outputs. Reports. ICTD2012 Peer Mentorship Program and Workshop : Report to the IDRC; final technical report. Download PDF ...

  3. Graduate and Research Program in Forced Migration and Refugee ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will enable Birzeit University, West Bank, to establish a graduate research and training program in refugee and forced migration studies as part of the master's program offered by the Ibrahim Abu-Lughod Institute of International ... Documents d'orientation inspirés de la recherche sur les réfugiés palestiniens.

  4. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    International Nuclear Information System (INIS)

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described

  5. LBNL Laboratory Directed Research and Development Program FY2016

    Energy Technology Data Exchange (ETDEWEB)

    Ho, D.

    2017-03-01

    The Berkeley Lab Laboratory Directed Research and Development Program FY2016 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the LDRD program planning and documentation process that includes an annual planning cycle, project selection, implementation and review.

  6. Joint University Program for Air Transportation Research, 1984

    Science.gov (United States)

    Morrell, Frederick R. (Compiler)

    1987-01-01

    The research conducted during 1984 under the NASA/FAA sponsored Joint University Program for Air Transportation Research is summarized. The Joint University Program is a coordinated set of three grants sponsored by NASA Langley Research Center and the Federal Aviation Administration, one each with the Massachusetts Institute of Technology, Ohio University, and Princeton University. Completed works, status reports, and bibliographies are presented for research topics, which include navigation, guidance, control and display concepts. An overview of the year's activities for each of the schools is also presented.

  7. Joint University Program for Air Transportation Research, 1988-1989

    Science.gov (United States)

    Morrell, Frederick R. (Compiler)

    1990-01-01

    The research conducted during 1988 to 1989 under the NASA/FAA-sponsored Joint University Program for Air Transportation Research is summarized. The Joint University Program is a coordinated set of three grants sponsored by NASA Langley Research Center and the Federal Aviation Administration, one each with the Massachusetts Institute of Technology, Ohio University, and Princeton University. Completed works, status reports, and annotated bibliographies are presented for research topics, which include computer science, guidance and control theory and practice, aircraft performance, flight dynamics, and applied experimental psychology. An overview of the year's activities for each university is also presented.

  8. Small Business Innovation Research and Small Business Technology Transfer Programs

    Science.gov (United States)

    Garrison, Lynn; Jasper, Gwen

    2015-01-01

    The Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) programs fund the research, development, and demonstration of innovative technologies that fulfill NASA's needs as described in the annual Solicitations and have significant potential for successful commercialization. The only eligible participants are small business concern (SBC) with 500 or fewer employees or a nonprofit research institute such as a university or a research laboratory with ties to an SBC. These programs are potential sources of seed funding for the development of small business innovations.

  9. Towards the final BSA modeling for the accelerator-driven BNCT facility at INFN LNL

    Energy Technology Data Exchange (ETDEWEB)

    Ceballos, C. [Centro de Aplicaciones Tecnlogicas y Desarrollo Nuclear, 5ta y30, Miramar, Playa, Ciudad Habana (Cuba); Esposito, J., E-mail: juan.esposito@lnl.infn.it [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Agosteo, S. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy); Colautti, P.; Conte, V.; Moro, D. [INFN, Laboratori Nazionali di Legnaro (LNL), via dell' Universita, 2, I-35020 Legnaro (PD) (Italy); Pola, A. [Politecnico di Milano, Dipartimento di Energia, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)] [INFN, Sezione di Milano, via Celoria 16, 20133 Milano (Italy)

    2011-12-15

    Some remarkable advances have been made in the last years on the SPES-BNCT project of the Istituto Nazionale di Fisica Nucleare (INFN) towards the development of the accelerator-driven thermal neutron beam facility at the Legnaro National Laboratories (LNL), aimed at the BNCT experimental treatment of extended skin melanoma. The compact neutron source will be produced via the {sup 9}Be(p,xn) reactions using the 5 MeV, 30 mA beam driven by the RFQ accelerator, whose modules construction has been recently completed, into a thick beryllium target prototype already available. The Beam Shaping Assembly (BSA) final modeling, using both neutron converter and the new, detailed, Be(p,xn) neutron yield spectra at 5 MeV energy recently measured at the CN Van de Graaff accelerator at LNL, is summarized here.

  10. Radioprotective agents to reduce BNCT (Boron Neutron Capture Therapy) induced mucositis in the hamster cheek pouch

    International Nuclear Information System (INIS)

    Monti Hughes, A.; Pozzi, E.C.C.; Thorp, S.

    2013-01-01

    Introduction: BNCT is based on the capture reaction between boron, selectively targeted to tumor tissue, and thermal neutrons which gives rise to lethal, short-range high linear energy transfer particles that selectively damage tumor tissue, sparing normal tissue. We previously evidenced a remarkable therapeutic success of BNCT mediated by boronophenylalanine (BPA) in the hamster cheek pouch oral cancer and pre cancer model. Despite therapeutic efficacy, mucositis induced in premalignant tissue was dose limiting and favored, in some cases, tumor development. In a clinical scenario, oral mucositis limits the dose administered to head and neck tumors. Aim: Our aim was to evaluate the effect of the administration of different radioprotective agents, seeking to reduce BNCT-induced mucositis to acceptable levels in dose-limiting premalignant tissue; without compromising therapeutic effect evaluated as inhibition on tumor development in premalignant tissue; without systemic or local side effects; and without negative effects on the biodistribution of the boron compound used for treatment. Materials and methods: Cancerized hamsters with DMBA (dimethylbenzanthracene) were treated with BPA-BNCT 5 Gy total absorbed dose to premalignant tissue, at the RA-3 Nuclear Reactor, divided into different groups: 1-treated with FLUNIXIN; 2- ATORVASTATIN; 3-THALIDOMIDE; 4-HISTAMINE (two concentrations: Low -1 mg/ml- and High -5 mg/ml-); 5-JNJ7777120; 6-JNJ10191584; 7-SALINE (vehicle). Cancerized animals without any treatment (neither BNCT nor radioprotective therapy) were also analyzed. We followed the animals during one month and evaluated the percentage of animals with unacceptable/severe mucositis, clinical status and percentage of animals with new tumors post treatment. We also performed a preliminary biodistribution study of BPA + Histamine “low” concentration to evaluate the potential effect of the radioprotector on BPA biodistribution. Results: Histamine

  11. Four cases of facial melanoma treated by BNCT with {sup 10}B-p-boronophenylalanine

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, H. [Tohoku Univ., IDAC, Sendai, Miyagi (Japan); Mishima, Y. [Mishima Institute for Dermatological Research, Kobe, Hyogo (Japan); Hiratsuka, J. [Kawasaki Medical School, Kurashiki, Okayama (Japan); Kobayashi, T. [Kyoto Univ., Kyoto (Japan); Karashima, H. [Mitsubishi Ind. Co. Ltd. (Japan); Yoshino, K. [Shinshu Univ., Matsumoto, Nagano (Japan); Tsuru, K.; Araki, K.; Ichihashi, M. [Kobe Univ., Kobe, Hyogo (Japan)

    2000-10-01

    We treated four cases of facial melanoma by BNCT with {sup 10}B-paraboronophenylalanine {center_dot} fructose complex (BPA). The patients received 180 to 200 mg BPA/kg-BW intravenously for 3 to 5 hours. One to two hours after the end of BPA administration, they were irradiated with a thermal neutron beam at the Kyoto University Reactor (KUR). The local control of the tumors was good and complete regression was achieved in all cases. The acute and subacute skin reactions ranged from dry desquamation to erosion and were within tolerable limits. After 2 to 3 months, the skin recovered from damage with slight pigmentation or depigmentation and without serious functional or cosmetic problems. Our results indicate BNCT of facial melanoma is promising not only for tumor cure but also for good QOL of the patients, although surgery is the standard and first choice for the treatment of malignant melanoma. (author)

  12. Monte Carlo simulations of the cellular S-value, lineal energy and RBE for BNCT

    International Nuclear Information System (INIS)

    Liu Chingsheng; Tung Chuanjong

    2006-01-01

    Due to the non-uniform uptake of boron-containing pharmaceuticals in cells and the short-ranged alpha and lithium particles, microdosimetry provides useful information on the cellular dose and response of boron neutron capture therapy (BNCT). Radiation dose and quality in BNCT may be expressed in terms of the cellular S-value and the lineal energy spectrum. In the present work, Monte Carlo simulations were performed to calculate these microdosimetric parameters for different source-target configurations and sizes in cells. The effective relative biological effectiveness (RBE) of the Tsing Hua Open-pool Reactor (THOR) epithermal neutron beam was evaluated using biological weighting functions that depended on the lineal energy. RBE changes with source-target configurations and sizes were analyzed. (author)

  13. Hyaluronic acid as a potential boron carrier for BNCT: Preliminary evaluation.

    Science.gov (United States)

    Zaboronok, A; Yamamoto, T; Nakai, K; Yoshida, F; Uspenskii, S; Selyanin, M; Zelenetskii, A; Matsumura, Akira

    2015-12-01

    Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different biological tissues, has the potential to attach to CD44 receptors on the surface of certain cancer cells, where the receptor is overexpressed compared with normal cells. Boron-hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. BHA with low-viscosity 30 kDa HA could be administered by intravenous injection. The compound showed a certain degree of cytotoxicity and accumulation in C6 rat glioma cells in vitro. Instability of the chelate bonds between boron and HA and/or insufficient specificity of CD44 receptors on C6 cells to BHA could account for the insufficient in vitro accumulation. To ensure the future eligibility of BHA for BNCT experiments, using alternative tumor cell lines and chemically securing the chelate bonds or synthesizing BHA with boron covalently attached to HA might be required. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT).

    Science.gov (United States)

    Wittig, Andrea; Michel, Jean; Moss, Raymond L; Stecher-Rasmussen, Finn; Arlinghaus, Heinrich F; Bendel, Peter; Mauri, Pier Luigi; Altieri, Saverio; Hilger, Ralf; Salvadori, Piero A; Menichetti, Luca; Zamenhof, Robert; Sauerwein, Wolfgang A G

    2008-10-01

    Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of 10B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of 10B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.

  15. On line local measurement of thermal neutron flux on BNCT patient using SPND

    International Nuclear Information System (INIS)

    Miller, M.E.; Sztejnberg Goncalves-Carralves, M.L.; Gonzalez, S.J.

    2006-01-01

    The first on-line neutron flux measurement on a patient using a self-powered neutron detector (SPND) was assessed during the fourth clinical trial of the Boron Neutron Capture Therapy (BNCT) Project carried out at the National Atomic Energy Commission of Argentina (CNEA) and the medical center Angel H. Roffo. The SPND was specially developed and assembled for BNCT by CNEA. Its small size, 1 cm sensible length and 1.9 mm diameter, allowed performing a localized measurement. Since the treated tumors were cutaneous melanomas of nodular type, the SPND was located on the patient's skin. The patient was exposed to three different and consecutive fields and in each of them the SPND was used to measure local thermal neutron fluxes at selected dosimetric reference points. The values of the measured fluxes agreed with the ones estimated by calculation. This trial also demonstrated the usefulness of the SPND for assessing flux on-line. (author)

  16. Thermally optimized lithium neutron producing target design for accelerator-based BNCT

    International Nuclear Information System (INIS)

    Park Shane; Joo Hyeong Min; Jang Byeong Ill; Jeun, Gyoodong; Kim Jong Kyung; Chai, Jong Seo

    2006-01-01

    In accelerator-based Boron Neutron Capture Therapy (BNCT), 7 Li(p,n) 7 Be reaction is prevalently used as a neutron source. However, lithium has a very low melting point and poor thermal conductivity. Thus lithium target needs an efficient cooling. In this study, ways of increasing proton beam diameter and slanting target are proposed to reduce the heat density of lithium target. Thermal analysis on the lithium target design shows that water cooling is feasible if the proton beam diameter and target slopes are in the available range of the contour plots generated from this study. On the basis of the thermal analysis, the prototype of target system was designed and manufactured. Full-model thermal analysis and temperature measuring experiment were subsequently performed. The calculated temperature distribution coincided with the contour plots and the experimental results. These results will be used in the manufacture of the prototype accelerator-based BNCT facility at Hanyang University. (author)

  17. Programs of the Office of Energy Research: Revision

    International Nuclear Information System (INIS)

    1987-06-01

    In establishing each of the Federal Agencies that have been successively responsible for energy technologies and their development - the Atomic Energy Commission, the Energy Research and Development Administration, and, currently, the US Department of Energy (DOE) - Congress made specific provisions for the conduct of advanced and fundamental research. The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research of this nature, which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the Unites States. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large. 5 figs., 6 tabs

  18. U.S. Nuclear Regulatory Commission natural analogue research program

    International Nuclear Information System (INIS)

    Kovach, L.A.; Ott, W.R.

    1995-01-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process

  19. Supporting medical education research quality: the Association of American Medical Colleges' Medical Education Research Certificate program.

    Science.gov (United States)

    Gruppen, Larry D; Yoder, Ernie; Frye, Ann; Perkowski, Linda C; Mavis, Brian

    2011-01-01

    The quality of the medical education research (MER) reported in the literature has been frequently criticized. Numerous reasons have been provided for these shortcomings, including the level of research training and experience of many medical school faculty. The faculty development required to improve MER can take various forms. This article describes the Medical Education Research Certificate (MERC) program, a national faculty development program that focuses exclusively on MER. Sponsored by the Association of American Medical Colleges and led by a committee of established medical education researchers from across the United States, the MERC program is built on a set of 11 interactive workshops offered at various times and places across the United States. MERC participants can customize the program by selecting six workshops from this set to fulfill requirements for certification. This article describes the history, operations, current organization, and evaluation of the program. Key elements of the program's success include alignment of program content and focus with needs identified by prospective users, flexibility in program organization and logistics to fit participant schedules, an emphasis on practical application of MER principles in the context of the participants' activities and interests, consistency in program content and format to ensure standards of quality, and a sustainable financial model. The relationship between the national MERC program and local faculty development initiatives is also described. The success of the MERC program suggests that it may be a possible model for nationally disseminated faculty development programs in other domains.

  20. A colorimetric determination of boron in biological sample for boron neutron capture therapy (BNCT)

    International Nuclear Information System (INIS)

    Camillo, M.A.P.; Tomac Junior, U.

    1990-01-01

    The boron neutron capture therapy (BNCT) has shown better prognosis in the treatment of glyemas and gluoblastomas grade III and IV than other therapies. During the treatment the levels of Na 2 10 B 12 H 11 SH must be known in several compartiments of the organism and with this purpose the method of colorimetric determination of boron using curcumine was established. This method is simple, reprodutible and adequate sensitivity for this control. (author) [pt

  1. Treatment planning capability assessment of a beam shaping assembly for accelerator-based BNCT.

    Science.gov (United States)

    Herrera, M S; González, S J; Burlon, A A; Minsky, D M; Kreiner, A J

    2011-12-01

    Within the frame of an ongoing project to develop a folded Tandem-Electrostatic-Quadrupole accelerator facility for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) a theoretical study was performed to assess the treatment planning capability of different configurations of an optimized beam shaping assembly for such a facility. In particular this study aims at evaluating treatment plans for a clinical case of Glioblastoma. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Human Factors Regulatory Research Program Plan, FY 1989--FY 1992

    International Nuclear Information System (INIS)

    Coffman, F.; Persensky, J.; Ryan, T.; Ramey-Smith, A.; Goodman, C.; Serig, D.; Trager, E; Nuclear Regulatory Commission, Washington, DC; Nuclear Regulatory Commission, Washington, DC; Nuclear Regulatory Commission, Washington, DC

    1989-10-01

    This report describes the currently ongoing (FY 1989) and planned (FY 1989-1992) Human Factors Regulatory Research Program in the NRC Office of Nuclear Regulatory Research (RES). Examples of the influence of human factors on nuclear safety are presented, and the role of personnel is discussed. Current regulatory issues associated with human factors in the nuclear system and the purpose of the research plan are provided. The report describes the research process applied to the human factors research issues and the program activities: Personnel Performance Measurement, Personnel Subsystem, Human-System Interface. Organization and Management, and Reliability Assessment. The research being conducted within each activity is summarized along with the objectives, background information, and expected regulatory products. Budget and personnel forecasts are provided along with a summary of contractors performing some of the ongoing research. Appendices contain a chronology of human factors research at NRC, a description of the research approach, an update on human factors programs and initiatives in RES and other NRC offices, and the integration among these programs. 46 refs., 5 tabs

  3. Danish integrated antimicrobial in resistance monitoring and research program

    DEFF Research Database (Denmark)

    Hammerum, Anette Marie; Heuer, Ole Eske; Emborg, Hanne-Dorthe

    2007-01-01

    a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research......Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish...... activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries....

  4. In vivo tyrosinase mini-gene transfer enhances killing effect of BNCT on amelanotic melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Kondoh, H.; Mishima, Y. [Mishima Institute for Dermatological Research, Kobe, Hyogo (Japan); Hiratsuka, J. [Kawasaki Medical School, Dept. of Radiation Oncology, Kurashiki, Okayama (Japan); Iwakura, M. [Kobe Univ. (Japan). School of Medicine

    2000-10-01

    Using accentuated melanogenesis principally occurring within melanoma cells, we have successfully treated human malignant melanoma (Mm) with {sup 10}B-BPA BNCT. Despite this success, there are still remaining issues for poorly melanogenic Mm and further non-pigment cell tumors. We found the selective accumulation of {sup 10}B-BPA to Mm is primarily due to the complex formation of BPA and melanin-monomers activity synthesized within Mm cells. Then, we succeeded in transferring the tyrosinase gene into amelanotic to substantially produce melanin monomers. These cells has demonstrated increased boron accumulation and enhanced killing effect of BNCT. Further, transfection of TRP-2 (DOPAchrome tautomerase) gene into poorly eumelanotic and slightly phenomelanotic Mm cells in culture cell systems also led to increased BPA accumulation. Thereafter, we studied in vivo gene transfer. We transferred the tyrosinase mini-gene by intra-tumor injection into poorly melanotic Mm proliferating subcutaneously in hamster skin, and performed BNCT. Compared to control tumors, gene-transferred tumors showed increased BPA accumulation leading to enhanced killing effect. (author)

  5. Hyaluronic acid as a potential boron carrier for BNCT: Preliminary evaluation

    International Nuclear Information System (INIS)

    Zaboronok, A.; Yamamoto, T.; Nakai, K.; Yoshida, F.; Uspenskii, S.; Selyanin, M.; Zelenetskii, A.; Matsumura, Akira

    2015-01-01

    Hyaluronic acid (HA), a nonimmunogenic, biocompatible polymer found in different biological tissues, has the potential to attach to CD44 receptors on the surface of certain cancer cells, where the receptor is overexpressed compared with normal cells. Boron–hyaluronic acid (BHA) was tested for its feasibility as a potential agent for BNCT. BHA with low-viscosity 30 kDa HA could be administered by intravenous injection. The compound showed a certain degree of cytotoxicity and accumulation in C6 rat glioma cells in vitro. Instability of the chelate bonds between boron and HA and/or insufficient specificity of CD44 receptors on C6 cells to BHA could account for the insufficient in vitro accumulation. To ensure the future eligibility of BHA for BNCT experiments, using alternative tumor cell lines and chemically securing the chelate bonds or synthesizing BHA with boron covalently attached to HA might be required. - Highlights: • Hyaluronic acid (HA) is a nonimmunogenic, biocompatible polymer. • Boron–HA (BHA) acid can contain a large number of boron atoms for BNCT. • Active targeting can be realized with CD44 and other HA receptors on tumor cells. • BHA showed a certain degree of toxicity against C6 tumor cells and V79 fibroblasts. • BHA was injected into rats via the tail vein, boron was detected in tumors in vivo.

  6. Monitoring total boron in blood for BNCT by a novel atomic emission method

    International Nuclear Information System (INIS)

    Laakso, J.; Kulvik, M.; Ruokonen, I.; Vaehaetalo, J.; Faerkkilae, M.; Kallio, M.; Zilliacus, R.

    2000-01-01

    In BNCT the duration and timing of the is adjusted by 10 B concentrations in whole blood. Time-frame for determinations is less than 20 minutes. Therefore fast and accurate boron determinations are a prerequisite for BNCT. We present a method based on ICP-AES instrument for whole blood and plasma boron determinations with protein precipitation with trichloroacetic acid as sample pre-treatment and beryllium as an internal standard. The method was compared to established but tedious ICP-mass spectrometric method with wet ashing as a sample pre-treatment. The ICP-AES method is in good agreement (correlation coefficient 0.99) the ICP-MS. Within-day and between-day imprecisions were less than 3,5% CV for whole blood samples. Samples taken during and after BPA-F infusion (290 mg/kg) revealed an uneven distribution between plasma and erythrocytes. The present method is feasible and one of the fastest currently available for BNCT. Our results indicate that BPA-F or its metabolites do not seem to be tightly bound to plasma proteins. It also seems that determination of boron in plasma sample may be preferable than measuring boron in whole blood. (author)

  7. Nuclear Explosion Monitoring Research and Engineering Program - Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Leslie A. [DOE/NNSA

    2004-09-01

    The Department of Energy (DOE)/National Nuclear Security Administration (NNSA) Nuclear Explosion Monitoring Research and Engineering (NEM R&E) Program is dedicated to providing knowledge, technical expertise, and products to US agencies responsible for monitoring nuclear explosions in all environments and is successful in turning scientific breakthroughs into tools for use by operational monitoring agencies. To effectively address the rapidly evolving state of affairs, the NNSA NEM R&E program is structured around three program elements described within this strategic plan: Integration of New Monitoring Assets, Advanced Event Characterization, and Next-Generation Monitoring Systems. How the Program fits into the National effort and historical accomplishments are also addressed.

  8. Internal Contamination Program in hospital and biomedical research institutions

    International Nuclear Information System (INIS)

    Tellez de Cepeda, M.; Macias, M.T.; Plaza, R.; Martinez Hidalgo, C.

    1992-01-01

    Program and the criteria for establishing such program to control the internal contamination from a point of view, not yet systematized and standardized in Hospital and Biomedical Research centers. The main purpose of this work is to review our own situation, to establish and systematize an operative program with variable means (instruments) and the use of external means if need. This program will be established taking into account the new recommendations of I.C.R.P. and the new criteria A.L.I. (author)

  9. Online Financial Education Programs: Theory, Research, and Recommendations

    Directory of Open Access Journals (Sweden)

    Jinhee Kim

    2017-03-01

    Full Text Available Technological advances have created unprecedented opportunities for online financial education that can be used to improve financial literacy and money management practices. While online financial education programs have become popular, relevant research and theoretical frameworks have rarely been considered in the development of such programs. This article synthesizes lessons from literature and theories for the development of an effective online financial education program. Drawing from literature on financial literacy education and online education, implications and recommendations for integrating technology into online financial education programs for adults are discussed.

  10. Research on the Academic Benefits of the Advanced Placement Program

    Directory of Open Access Journals (Sweden)

    Russell T. Warne

    2017-01-01

    Full Text Available With more than 3 million participants per year, the Advanced Placement (AP program is one of the most popular programs in the United States for exposing high-achieving high school students to advanced academic content. Sponsored by the College Board, the AP program provides a framework in which high school teachers can teach introductory college-level courses to high school students. These students then take one of 34 standardized tests at the end of the year, and students who score well on their course’s AP test can receive college credit from their university in which they later enroll. Despite the popularity of the AP program, remarkably little independent research has been conducted on the academic benefits of AP. In this article, I summarize the state of knowledge about the academic benefits of AP. Previous research and descriptive data indicate that AP students outperform non-AP students on a variety of academic measures, but many other aspects of the program are poorly understood, partially due to variability across AP subjects. These aspects include the causal impact of AP, which components of the program are most effective in boosting academic achievement, and how students engage with the AP program. I also conclude by making suggestions for researchers to use new methodologies to investigate new scientific and policy questions and new student populations to improve the educational scholars’ and practitioners’ understanding of the AP program.

  11. Radiochemistry Education and Research Program at the Pennsylvania State University

    International Nuclear Information System (INIS)

    Uenlue, Kenan

    2009-01-01

    A new Radiochemistry Education and Research Program was started at the Pennsylvania University, Radiation Science and Engineering Center. The program was initially supported by the Department of Energy, Radiochemistry Education Award Program (REAP). Using REAP funding as leverage we obtained support from the Los Alamos National Laboratory, Department of Homeland Security, Domestic Nuclear Detection Office, various internal funding from PSU and other entities. The PSU radiochemistry program primarily addresses radiochemistry education and secondarily nuclear and radiochemistry research. The education program consists of bolstering our existing radiochemistry and related courses; Nuclear and Radiochemistry, Radiation Detection and Measurement, Radiological Safety and developing new courses, e.g., Laboratory Experiments in Applied Nuclear and Radiochemistry, and Nuclear Methods in Science. A new laboratory has been created with state of the art equipment for the Laboratory Experiments in Applied Nuclear and Radiochemistry course. We also plan to revitalize the nuclear and radiochemistry research programs. We established a state-of-the-art Neutron Activation Analysis Laboratory and a gamma ray spectroscopy laboratory that has 10 stations including state-of-the-art nuclear spectroscopy hardware and software. In addition, we embarked on an expansion plan that included building a new neutron beam hall and neutron beam ports with a cold neutron source. One of the reasons to have a cold neutron source is for the development of a prompt gamma activation analysis facility. A detailed description of PSU radiochemistry education and research program will be given and the future plans will be discussed.

  12. Management and research priorities of NASA 'Human Research Program'

    International Nuclear Information System (INIS)

    Zhou Weijun; Diao Tianxi; Li Lijuan; Li Zulan

    2013-01-01

    Research on humans has been the focus of the United States space biomedical research, while 'Human Research Program', as an important project initiated by NASA, aims to reduce the risks to the health and performance of astronauts. This paper analyzed this project in terms of organization and management, funding investment and research directions. (authors)

  13. Summary results of an assessment of research projects in the Nuclear Medicine Research program

    International Nuclear Information System (INIS)

    1988-01-01

    In May 1987, OHER management requested the Office of Program Analysis (OPA) to conduct a peer review of the projects of the DOE Nuclear Medicine Research program. This was done using procedures and a quantitative methodology OPA developed for assessing DOE research programs. Sixty-three individual nuclear medicine projects were reviewed by seven panels; one panel on isotopes and radioisotopes, three on radiopharmacology, two on clinical feasibility, and one on instrumentation. Each panel consisted of five to ten knowledgeable reviewers. 5 figs

  14. Human Research Program Integrated Research Plan: December 20, 2007, Interim Baseline

    Science.gov (United States)

    2008-01-01

    The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. This Integrated Research Plan (IRP) describes the program s research activities that are intended to address the needs of human space exploration and serve HRP customers. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration. The document serves several purposes for the Human Research Program: The IRP provides a means to assure that the most significant risks to human space explorers are being adequately mitigated and/or addressed, The IRP shows the relationship of research activities to expected outcomes and need dates, The IRP shows the interrelationships among research activities that may interact to produce products that are integrative or cross defined research disciplines, The IRP illustrates the non-deterministic nature of research and technology activities by showing expected decision points and potential follow-on activities, The IRP shows the assignments of responsibility within the program organization and, as practical, the intended solicitation approach, The IRP shows the intended use of research platforms such as the International Space Station, NASA Space Radiation Laboratory, and various space flight analogs. The IRP does not show all budgeted activities of the Human research program, as some of these are enabling functions, such as management, facilities and infrastructure

  15. Air Breathing Propulsion Controls and Diagnostics Research at NASA Glenn Under NASA Aeronautics Research Mission Programs

    Science.gov (United States)

    Garg, Sanjay

    2015-01-01

    The Intelligent Control and Autonomy Branch (ICA) at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet the goals of the NASA Aeronautics Research Mission Directorate (ARMD) Programs. These efforts are primarily under the various projects under the Advanced Air Vehicles Program (AAVP), Airspace Operations and Safety Program (AOSP) and Transformative Aeronautics Concepts Program (TAC). The ICA Branch is focused on advancing the state-of-the-art of aero-engine control and diagnostics technologies to help improve aviation safety, increase efficiency, and enable operation with reduced emissions. This paper describes the various ICA research efforts under the NASA Aeronautics Research Mission Programs with a summary of motivation, background, technical approach, and recent accomplishments for each of the research tasks.

  16. ACRS review of the 1983 NRC Safety Research Program

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    This article provides a review of the Nuclear Regulatory Commission (NRC) Safety Research Program for FY 1983. The NRC Safety Research Program support funding is $196.6 million in FY 1982, and the proposed budget for FY 1983 is $195.2 million. The requested level of funding for FY 1982, recommended by the ACRS and partially accepted by the NRC, was reduced significantly by the Congress in response to the administration's budget-reduction program. At the same time, the Congress directed a delay in the timing of the LOFT phaseout. This review of the FY 1983 program again focuses on priorities in research and recommends certain reallocations of funds. If the funding for LOFT is increased from that in the proposed budget, based on the current schedule for phaseout, many of the actions recommended in this review should be reexamined

  17. Laboratory Directed Research and Development Program Assessment for FY 2008

    Energy Technology Data Exchange (ETDEWEB)

    Looney, J P; Fox, K J

    2008-03-31

    Brookhaven National Laboratory (BNL) is a multidisciplinary Laboratory that carries out basic and applied research in the physical, biomedical, and environmental sciences, and in selected energy technologies. It is managed by Brookhaven Science Associates, LLC, (BSA) under contract with the U. S. Department of Energy (DOE). BNL's Fiscal Year 2008 spending was $531.6 million. There are approximately 2,800 employees, and another 4,300 guest scientists and students who come each year to use the Laboratory's facilities and work with the staff. The BNL Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) annually in March, as required by DOE Order 413.2B, 'Laboratory Directed Research and Development,' April 19, 2006, and the Roles, Responsibilities, and Guidelines for Laboratory Directed Research and Development at the Department of Energy/National Nuclear Security Administration Laboratories dated June 13, 2006. The goals and objectives of BNL's LDRD Program can be inferred from the Program's stated purposes. These are to (1) encourage and support the development of new ideas and technology, (2) promote the early exploration and exploitation of creative and innovative concepts, and (3) develop new 'fundable' R&D projects and programs. The emphasis is clearly articulated by BNL to be on supporting exploratory research 'which could lead to new programs, projects, and directions' for the Laboratory. To be a premier scientific Laboratory, BNL must continuously foster groundbreaking scientific research and renew its research agenda. The competition for LDRD funds stimulates Laboratory scientists to think in new and creative ways, which becomes a major factor in achieving and maintaining research excellence and a means to address National needs within the overall mission of the DOE and BNL. By fostering high-risk, exploratory research, the LDRD program helps

  18. Joint Canada-Israel Health Research Program | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Immunology research can also tackle some of the major health challenges low and middle-income countries face, such as HIV/AIDS, cancer, vaccine development, and infectious diseases. To that end, the Joint Canada-Israel Health Research Program is supporting six projects led by world-class teams that were selected ...

  19. Application of Logic Models in a Large Scientific Research Program

    Science.gov (United States)

    O'Keefe, Christine M.; Head, Richard J.

    2011-01-01

    It is the purpose of this article to discuss the development and application of a logic model in the context of a large scientific research program within the Commonwealth Scientific and Industrial Research Organisation (CSIRO). CSIRO is Australia's national science agency and is a publicly funded part of Australia's innovation system. It conducts…

  20. A recommended program of tritium monitoring research and development

    International Nuclear Information System (INIS)

    Nickerson, S.B.; Gerdingh, R.F.; Penfold, K.

    1982-10-01

    This report presents recommendations for programs of research and development in tritium monitoring instrumentation. These recommendations, if implemented, will offer Canadian industry the opportunity to develop marketable instruments. The major recommendations are to assist in the development and promotion of two Chalk River Nuclear Laboratories' monitors and an Ontario Hydro monitor, and to support research and development of a surface monitor

  1. How one teacher research experience program is transforming STEM education

    Science.gov (United States)

    Warburton, J.; Fahnestock, J.; Larson, A.

    2016-12-01

    Celebrating over 10 years of success, the PolarTREC-Teachers and Researchers Exploring and Collaborating program, administered by the Arctic Research Consortium of the United States, is a unique professional development program for United States educators and polar researchers. Through an innovative teacher research experience, utilizing field-based experiences in the polar regions, PolarTREC provides teachers the content knowledge, pedagogical tools, confidence, understanding of science in the broader society, and experiences with scientific inquiry they need to promote authentic scientific research in their classroom. The program evaluation objectives were 1) to better understand the immediate impacts of the program on participating teachers, their students, and the researchers with whom they partnered; and 2) to explore the long-term impacts of the PolarTREC experiences on participating teachers' professional experiences, and in particular their use of authentic scientific research with their students and ongoing relationships with researcher team members and other PolarTREC teachers. In this presentation, we will share our data on how the PolarTREC model is transforming STEM educators not only how they teach science in their classroom but also how they both perceive science, a paradigm shift, that defines their careers.

  2. Trends and Features of Student Research Integration in Educational Program

    Science.gov (United States)

    Grinenko, Svetlana; Makarova, Elena; Andreassen, John-Erik

    2016-01-01

    This study examines trends and features of student research integration in educational program during international cooperation between Østfold University College in Norway and Southern Federal University in Russia. According to research and education approach the international project is aimed to use four education models, which linked student…

  3. Fire, Fuel, and Smoke Science Program: 2013 Research accomplishments

    Science.gov (United States)

    Faith Ann Heinsch; Robin J. Innes; Colin C. Hardy; Kristine M. Lee

    2014-01-01

    The Fire, Fuel, and Smoke Science Program (FFS) of the U.S. Forest Service, Rocky Mountain Research Station, focuses on fundamental and applied research in wildland fire, from fire physics and fire ecology to fuels management and smoke emissions. Located at the Missoula Fire Sciences Laboratory in Montana, the scientists, engineers, technicians, and support staff in...

  4. Fire, Fuel, and Smoke Science Program 2015 Research Accomplishments

    Science.gov (United States)

    Faith Ann Heinsch; Charles W. McHugh; Colin C. Hardy

    2016-01-01

    The Fire, Fuel, and Smoke Science Program (FFS) of the U.S. Forest Service, Rocky Mountain Research Station focuses on fundamental and applied research in wildland fire, from fire physics and fire ecology to fuels management and smoke emissions. Located at the Missoula Fire Sciences Laboratory in Montana, the scientists, engineers, technicians, and support...

  5. Research program annual review, 1991-92. Annual publication

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-12-31

    This report highlights the year`s activities of the Research Branch of the British Columbia Ministry of Forests in such areas as silviculture, sustainable and integrated resource management, hardwoods management, tree seedling production, forest ecology, growth and yield studies, environmental impacts, integrated wildlife/forestry studies, and collaboration with other agencies. A financial summary of research program expenditures is included.

  6. A Summary of the Naval Postgraduate School Research Program.

    Science.gov (United States)

    1979-09-30

    research at UCLA. Together with K. Woehler, a DNA funded program on X-ray emission from labor induced pinches continued. This research supports the DNA...marine fog from FNOC model output parameters, fog-frequency clima - tology and persistence. A six-stage sequen- tial development model of visibility

  7. Fire, Fuel, and Smoke Program: 2014 Research Accomplishments

    Science.gov (United States)

    Faith Ann Heinsch; Robin J. Innes; Colin C. Hardy; Kristine M. Lee

    2015-01-01

    The Fire, Fuel, and Smoke Science Program (FFS) of the U.S. Forest Service, Rocky Mountain Research Station focuses on fundamental and applied research in wildland fire, from fire physics and fire ecology to fuels management and smoke emissions. Located at the Missoula Fire Sciences Laboratory in Montana, the scientists, engineers, technicians, and support staff in FFS...

  8. Tritium radiobiology research in the US DOE program

    International Nuclear Information System (INIS)

    Carsten, A.L.

    1986-01-01

    The history of the original US Atomic Energy Commission, its replacement, the Energy Research and Development Administration, and the present Department of Energy's interest and sponsorship of tritium radiobiology is reviewed beginning in 1971 and continuing through 1986. In particular, the four remaining US Department of Energy, Division of Health and Environmental Research programs are described in some detail

  9. Research on teacher education programs: logic model approach.

    Science.gov (United States)

    Newton, Xiaoxia A; Poon, Rebecca C; Nunes, Nicole L; Stone, Elisa M

    2013-02-01

    Teacher education programs in the United States face increasing pressure to demonstrate their effectiveness through pupils' learning gains in classrooms where program graduates teach. The link between teacher candidates' learning in teacher education programs and pupils' learning in K-12 classrooms implicit in the policy discourse suggests a one-to-one correspondence. However, the logical steps leading from what teacher candidates have learned in their programs to what they are doing in classrooms that may contribute to their pupils' learning are anything but straightforward. In this paper, we argue that the logic model approach from scholarship on evaluation can enhance research on teacher education by making explicit the logical links between program processes and intended outcomes. We demonstrate the usefulness of the logic model approach through our own work on designing a longitudinal study that focuses on examining the process and impact of an undergraduate mathematics and science teacher education program. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. The 2003 NASA Faculty Fellowship Program Research Reports

    Science.gov (United States)

    Nash-Stevenson, S. K.; Karr, G.; Freeman, L. M.; Bland, J. (Editor)

    2004-01-01

    For the 39th consecutive year, the NASA Faculty Fellowship Program (NFFP) was conducted at Marshall Space Flight Center. The program was sponsored by NASA Headquarters, Washington, DC, and operated under contract by The University of Alabama in Huntsville. In addition, promotion and applications are managed by the American Society for Engineering Education (ASEE) and assessment is completed by Universities Space Research Association (USRA). The nominal starting and finishing dates for the 10-week program were May 27 through August 1, 2003. The primary objectives of the NASA Faculty Fellowship Program are to: (1) Increase the quality and quantity of research collaborations between NASA and the academic community that contribute to NASA s research objectives; (2) provide research opportunities for college and university faculty that serve to enrich their knowledge base; (3) involve students in cutting-edge science and engineering challenges related to NASA s strategic enterprises, while providing exposure to the methods and practices of real-world research; (4) enhance faculty pedagogy and facilitate interdisciplinary networking; (5) encourage collaborative research and technology transfer with other Government agencies and the private sector; and (6) establish an effective education and outreach activity to foster greater awareness of this program.

  11. Measurement of in-phantom neutron flux and gamma dose in Tehran research reactor boron neutron capture therapy beam line.

    Science.gov (United States)

    Bavarnegin, Elham; Sadremomtaz, Alireza; Khalafi, Hossein; Kasesaz, Yaser

    2016-01-01

    Determination of in-phantom quality factors of Tehran research reactor (TRR) boron neutron capture therapy (BNCT) beam. The doses from thermal neutron reactions with 14N and 10B are calculated by kinetic energy released per unit mass approach, after measuring thermal neutron flux using neutron activation technique. Gamma dose is measured using TLD-700 dosimeter. Different dose components have been measured in a head phantom which has been designed and constructed for BNCT purpose in TRR. Different in-phantom beam quality factors have also been determined. This study demonstrates that the TRR BNCT beam line has potential for treatment of superficial tumors.

  12. Incorporating resident research into the dermatology residency program

    Science.gov (United States)

    Wagner, Richard F; Raimer, Sharon S; Kelly, Brent C

    2013-01-01

    Programmatic changes for the dermatology residency program at The University of Texas Medical Branch were first introduced in 2005, with the faculty goal incorporating formal dermatology research projects into the 3-year postgraduate training period. This curriculum initially developed as a recommendation for voluntary scholarly project activity by residents, but it evolved into a program requirement for all residents in 2009. Departmental support for this activity includes assignment of a faculty mentor with similar interest about the research topic, financial support from the department for needed supplies, materials, and statistical consultation with the Office of Biostatistics for study design and data analysis, a 2-week elective that provides protected time from clinical activities for the purpose of preparing research for publication and submission to a peer-reviewed medical journal, and a departmental award in recognition for the best resident scholarly project each year. Since the inception of this program, five classes have graduated a total of 16 residents. Ten residents submitted their research studies for peer review and published their scholarly projects in seven dermatology journals through the current academic year. These articles included three prospective investigations, three surveys, one article related to dermatology education, one retrospective chart review, one case series, and one article about dermatopathology. An additional article from a 2012 graduate about dermatology education has also been submitted to a journal. This new program for residents was adapted from our historically successful Dermatology Honors Research Program for medical students at The University of Texas Medical Branch. Our experience with this academic initiative to promote dermatology research by residents is outlined. It is recommended that additional residency programs should consider adopting similar research programs to enrich resident education. PMID:23901305

  13. Solar heating and cooling commercialization research program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, D.L.; Tragert, W.; Weir, S.

    1979-11-01

    The Solar Heating and Cooling Commercialization Research Program has addressed a recognized need to accelerate the commercialization of solar products. The development of communication techniques and materials for a target group of heating, ventilating and air-conditioning (HVAC) wholesalers and distributors has been the primary effort. A summary of the program, the approach to the development of the techniques and materials, the conclusions derived from seminar feedback, the development of additional research activities and reports and the recommendations for follow-on activities are presented. The appendices offer detailed information on specific elements of the research effort.

  14. Research training needs in Peruvian national TB/HIV programs

    Science.gov (United States)

    2010-01-01

    Background There are few published reports of research training needs assessments and research training programs. In an effort to expand this nascent field of study and to bridge the gap between research and practice, we sought to systematically assess the research training needs of health care professionals working at Peruvian governmental institutions leading HIV and tuberculosis (TB) control and among senior stakeholders in the field. Methods Six institutional workshops were conducted with the participation of 161 mid-level health professionals from agencies involved in national HIV and TB control. At each workshop informants completed a structured questionnaire and participated in small and large group discussions. Additional data and institutional commitment was obtained through in-depth interviews from 32 senior managers and researchers from the Ministry of Health, academia and NGOs. Results Participants exhibited an overwhelming receptivity for additional research training, observing a gap between current levels of research training and their perceived importance. Specialized skills in obtaining funding, developing research protocols, particularly in operational, behavioral and prevention research were considered in greatest need. Beyond research training, participants identified broader social, economic and political factors as influential in infectious disease control. Conclusions The needs assessment suggests that future training should focus on operational research techniques, rather than on clinical skill building or program implementation only. Strengthening health systems not only requires additional research training, but also adequate financial resources to implement research findings. PMID:20875140

  15. Federal Geothermal Research Program Update Fiscal Year 1999

    Energy Technology Data Exchange (ETDEWEB)

    2004-02-01

    The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. To develop the technology needed to harness the Nation's vast geothermal resources, DOE's Office of Geothermal and Wind Technologies oversees a network of national laboratories, industrial contractors, universities, and their subcontractors. The following mission and goal statements guide the overall activities of the Office of Geothermal and Wind Technologies. This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 1999. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal and Wind Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  16. Neutron flux and gamma dose measurement in the BNCT irradiation facility at the TRIGA reactor of the University of Pavia

    Science.gov (United States)

    Bortolussi, S.; Protti, N.; Ferrari, M.; Postuma, I.; Fatemi, S.; Prata, M.; Ballarini, F.; Carante, M. P.; Farias, R.; González, S. J.; Marrale, M.; Gallo, S.; Bartolotta, A.; Iacoviello, G.; Nigg, D.; Altieri, S.

    2018-01-01

    University of Pavia is equipped with a TRIGA Mark II research nuclear reactor, operating at a maximum steady state power of 250 kW. It has been used for many years to support Boron Neutron Capture Therapy (BNCT) research. An irradiation facility was constructed inside the thermal column of the reactor to produce a sufficient thermal neutron flux with low epithermal and fast neutron components, and low gamma dose. In this irradiation position, the liver of two patients affected by hepatic metastases from colon carcinoma were irradiated after borated drug administration. The facility is currently used for cell cultures and small animal irradiation. Measurements campaigns have been carried out, aimed at characterizing the neutron spectrum and the gamma dose component. The neutron spectrum has been measured by means of multifoil neutron activation spectrometry and a least squares unfolding algorithm; gamma dose was measured using alanine dosimeters. Results show that in a reference position the thermal neutron flux is (1.20 ± 0.03) ×1010 cm-2 s-1 when the reactor is working at the maximum power of 250 kW, with the epithermal and fast components, respectively, 2 and 3 orders of magnitude lower than the thermal component. The ratio of the gamma dose with respect to the thermal neutron fluence is 1.2 ×10-13 Gy/(n/cm2).

  17. UNIVERSITY TURBINE SYSTEMS RESEARCH PROGRAM SUMMARY AND DIRECTORY

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence P. Golan; Richard A. Wenglarz

    2004-07-01

    The South Carolina Institute for Energy Studies (SCIES), administratively housed at Clemson University, has participated in the advancement of combustion turbine technology for over a decade. The University Turbine Systems Research Program, previously referred to as the Advanced Gas Turbine Systems Research (AGTSR) program, has been administered by SCIES for the U.S. DOE during the 1992-2003 timeframe. The structure of the program is based on a concept presented to the DOE by Clemson University. Under the supervision of the DOE National Energy Technology Laboratory (NETL), the UTSR consortium brings together the engineering departments at leading U.S. universities and U.S. combustion turbine developers to provide a solid base of knowledge for the future generations of land-based gas turbines. In the UTSR program, an Industrial Review Board (IRB) (Appendix C) of gas turbine companies and related organizations defines needed gas turbine research. SCIES prepares yearly requests for university proposals to address the research needs identified by the IRB organizations. IRB technical representatives evaluate the university proposals and review progress reports from the awarded university projects. To accelerate technology transfer technical workshops are held to provide opportunities for university, industry and government officials to share comments and improve quality and relevancy of the research. To provide educational growth at the Universities, in addition to sponsored research, the UTSR provides faculty and student fellowships. The basis for all activities--research, technology transfer, and education--is the DOE Turbine Program Plan and identification, through UTSR consortium group processes, technology needed to meet Program Goals that can be appropriately researched at Performing Member Universities.

  18. Laboratory Directed Research and Development Program FY2004

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Todd C.

    2005-03-22

    The Ernest Orlando Lawrence Berkeley National Laboratory (Berkeley Lab or LBNL) is a multi-program national research facility operated by the University of California for the Department of Energy (DOE). As an integral element of DOE's National Laboratory System, Berkeley Lab supports DOE's missions in fundamental science, energy resources, and environmental quality. Berkeley Lab programs advance four distinct goals for DOE and the nation: (1) To perform leading multidisciplinary research in the computing sciences, physical sciences, energy sciences, biosciences, and general sciences in a manner that ensures employee and public safety and protection of the environment. (2) To develop and operate unique national experimental facilities for qualified investigators. (3) To educate and train future generations of scientists and engineers to promote national science and education goals. (4) To transfer knowledge and technological innovations and to foster productive relationships among Berkeley Lab's research programs, universities, and industry in order to promote national economic competitiveness. Berkeley Lab's research and the Laboratory Directed Research and Development (LDRD) program support DOE's Strategic Goals that are codified in DOE's September 2003 Strategic Plan, with a primary focus on Advancing Scientific Understanding. For that goal, the Fiscal Year (FY) 2004 LDRD projects support every one of the eight strategies described in the plan. In addition, LDRD efforts support the goals of Investing in America's Energy Future (six of the fourteen strategies), Resolving the Environmental Legacy (four of the eight strategies), and Meeting National Security Challenges (unclassified fundamental research that supports stockpile safety and nonproliferation programs). The LDRD supports Office of Science strategic plans, including the 20 year Scientific Facilities Plan and the draft Office of Science Strategic Plan. The research also

  19. Socio-economic research in support of climate policy development: Mistra's Research Program Clipore.

    Science.gov (United States)

    Grennfelt, Peringe; Kjellén, Bo; Linnér, Björn-Ola; Zetterberg, Lars

    2012-01-01

    Mistra's Climate Policy Research Program, Clipore, is one of the largest research programs directed to support international climate policy development, involving research groups in Sweden, Norway, United States and India. It has been running from 2004 to 2011 with a budget of more than 100 MSEK (15 M USD). The paper briefly describes the program and its outcomes in relation to climate policy development. Discussion focuses on how the program has been able to be in the front of and include the development of emissions trading systems in Europe and the United States and how the program has been able to follow and produce inputs to the agenda of the United Nations Framework Convention on Climate Change (UNFCCC). The paper also discusses how the program has managed to present its outcomes and maintain an active dialogue with the various stakeholders. The paper emphasises options and obstacles in the communication between science and policy.

  20. Summary of entire research achievements of creative engineering research program on nuclear fuel cycle

    International Nuclear Information System (INIS)

    Takenaka, Shingo; Ikegami, Tetsuo

    2008-03-01

    Creative Engineering Research Program on Nuclear Fuel Cycle (former In-house Innovative Research Encouraging Program) was implemented from FY 2001 to FY 2007 in order to support such in-house researches that create innovative new concepts and aim technical break-through. Totally 37 applications have been received and 14 research themes have been accepted and been performed in this program. As for the research achievements of the 14 research themes, first author papers accepted by scientific journals and by science councils were 47 and 32, respectively, and oral presentations at scientific societies were 99. Furthermore, interpretive articles for scientific journals, requested lectures, patents, and prize winnings were 13, 30, 8, and 3, respectively. Consequently, it can be evaluated that the research achievements resulted from this program are generally in high level and that the expectations, at the starting point of this program, to activate the innovative research activities have been accomplished. In this report, the final reports of the 14 research themes together with the outline of this program are included. (author)