Thermal hydraulic design features for the BNCT application. Final report
Energy Technology Data Exchange (ETDEWEB)
Blue, T.E.; Vafai, K.
1993-06-01
This project report is based on our investigations for thermal design of a heat pipe for removing generated heat resulting from Proton bombardments of a Lithium target for a BNCT application. In our investigation, an integral analysis was employed to investigate the vapor an liquid flow in a flat plate heat pipe heated asymmetrically for removal of the 75 kW generated from the BNCT application. The flat plate heat pipe configuration will be used for removing the heat which is generated as a result of proton bombardment of the lithium target. The working fluid in the heat pipe occurs in two phase namely liquid and vapor. The wick contains all the liquid phase and the vapor phase is mainly in the core region. Heat is applied by an external source at the evaporator section which vaporizes the working fluid in this section. This results in a pressure difference which drives the vapor to the condenser section where condenses and releases latent heat of vaporization to a heat sink in the condense section. Due to the vaporization of liquid in the evaporator, the liquid-vapor interface enters into the wick surface and hence capillary pressure is developed there. This capillary pressure causes the condensed liquid in the condenser to be pumped back to the evaporator again. The results of our investigation have enabled us to correlate such diverse information as; the thickness of the wick, the diameter of the heat pipe, the wetting angle, the capillary radius, the surface tension, the latent heat of evaporation, the permeability and porosity of the chosen wick, the length of the heat pipe, and the viscosity and density of the two phases; with the heat removal capabilities of the heat pipe. Expressions for the pressure and velocity distributions are obtained and discussed in relation to our application to BNCT. The present design clearly shows that it is possible to attain temperatures well below the melting temperature of the lithium in the BNCT application.
Radiation shielding design of BNCT treatment room for D-T neutron source.
Pouryavi, Mehdi; Farhad Masoudi, S; Rahmani, Faezeh
2015-05-01
Recent studies have shown that D-T neutron generator can be used as a proper neutron source for Boron Neutron Capture Therapy (BNCT) of deep-seated brain tumors. In this paper, radiation shielding calculations have been conducted based on the computational method for designing a BNCT treatment room for a recent proposed D-T neutron source. By using the MCNP-4C code, the geometry of the treatment room has been designed and optimized in such a way that the equivalent dose rate out of the treatment room to be less than 0.5μSv/h for uncontrolled areas. The treatment room contains walls, monitoring window, maze and entrance door. According to the radiation protection viewpoint, dose rate results of out of the proposed room showed that using D-T neutron source for BNCT is safe. Copyright © 2015 Elsevier Ltd. All rights reserved.
Directory of Open Access Journals (Sweden)
I Made Ardana
2017-10-01
OPTIMASI DESAIN KOLIMATOR NEUTRON UNTUK SISTEM BNCT DAN UJI DOSIMETRINYA MENGGUNAKAN PROGRAM MCNPX. Telah dilakukan penelitian tentang sistem BNCT yang meliputi dua tahapan simulasi dengan menggunakan program MCNPX yaitu uji simulasi untuk optimasi desain kolimator neutron untuk sistem BNCT berbasis Siklotron 30 MeV dan uji simulasi untuk menghitung fluks neutron dan dosimetri radiasi pada kanker sarkoma jaringan lunak pada leher dan kepala. Tujuan simulasi untuk mendapatkan desain kolimator yang paling optimal dalam memoderasi fluks neutron cepat yang dihasilkan dari sistem target berilium sehingga dapat dihasilkan fluks neutron yang sesuai untuk sistem BNCT. Uji optimasi dilakukan dengan cara memvariasikan bahan dan ketebalan masing-masing komponen dalam kolimator seperi reflektor, moderator, filter neutron cepat, filter neutron thermal, filter radiasi gamma dan lubang keluaran. Desain kolimator yang diperoleh dari hasil optimasi tersusun atas moderator berbahan Al dengan ketebalan 39 cm, filter neutron cepat berbahan LiF2 setebal 8,2 cm, dan filter neutron thermal berbahan B4C setebal 0,5 cm. Untuk reflektor, filter radiasi gamma dan lubang keluaran masing-masing menggunakan bahan PbF2, Pb dan Bi. Fluks neutron epithermal yang dihasilkan dari kolimator yang didesain adalah sebesar 2,83 x 109 n/s cm-2 dan telah memenuhi seluruh parameter fluks neutron yang sesuai untuk sistem BNCT. Selanjutnya uji simulasi dosimetri pada kanker sarkoma jaringan lunak pada leher dan kepala dilakukan dengan cara memvariasikan konsentrasi senyawa boron pada model phantom leher manusia (ORNL. Selanjutnya model phantom tersebut diiradiasi dengan fluks neutron yang berasal dari kolimator yang telah didesain sebelumnya. Hasilnya, fluks neutron thermal mencapai nilai tertinggi pada kedalaman 4,8 cm di dalam model phantom leher ORNL dengan laju dosis tertinggi terletak pada area jaringan kanker. Untuk masing-masing variasi konsentrasi senyawa boron pada model phantom leher ORNL supaya
Thermally optimized lithium neutron producing target design for accelerator-based BNCT
International Nuclear Information System (INIS)
Park Shane; Joo Hyeong Min; Jang Byeong Ill; Jeun, Gyoodong; Kim Jong Kyung; Chai, Jong Seo
2006-01-01
In accelerator-based Boron Neutron Capture Therapy (BNCT), 7 Li(p,n) 7 Be reaction is prevalently used as a neutron source. However, lithium has a very low melting point and poor thermal conductivity. Thus lithium target needs an efficient cooling. In this study, ways of increasing proton beam diameter and slanting target are proposed to reduce the heat density of lithium target. Thermal analysis on the lithium target design shows that water cooling is feasible if the proton beam diameter and target slopes are in the available range of the contour plots generated from this study. On the basis of the thermal analysis, the prototype of target system was designed and manufactured. Full-model thermal analysis and temperature measuring experiment were subsequently performed. The calculated temperature distribution coincided with the contour plots and the experimental results. These results will be used in the manufacture of the prototype accelerator-based BNCT facility at Hanyang University. (author)
INEL BNCT Research Program annual report 1994
International Nuclear Information System (INIS)
Venhuizen, J.R.
1995-11-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included
Design of a beam shaping assembly for an accelerator-based BNCT system
International Nuclear Information System (INIS)
Stichelbaut, F.; Forton, E.; Jongen, Y.
2006-01-01
A complete BNCT system based on a high-intensity proton accelerator is developed by the IBA company. The neutron beam is produced via the 7 Li(p,n) 7 Be reaction using a solid lithium target. The neutron energy spectrum is tailored with a beam shaping assembly surrounding the target. This device is the object of an extensive R and D project and is fully designed with the Monte Carlo simulation code MCNPX. The emphasis is put on the treatment quality, notably the radiation dose at the skin level, and the achievable neutron flux. (author)
Automated electronic filter design
Banerjee, Amal
2017-01-01
This book describes a novel, efficient and powerful scheme for designing and evaluating the performance characteristics of any electronic filter designed with predefined specifications. The author explains techniques that enable readers to eliminate complicated manual, and thus error-prone and time-consuming, steps of traditional design techniques. The presentation includes demonstration of efficient automation, using an ANSI C language program, which accepts any filter design specification (e.g. Chebyschev low-pass filter, cut-off frequency, pass-band ripple etc.) as input and generates as output a SPICE(Simulation Program with Integrated Circuit Emphasis) format netlist. Readers then can use this netlist to run simulations with any version of the popular SPICE simulator, increasing accuracy of the final results, without violating any of the key principles of the traditional design scheme.
2.5 MeV CW 4-vane RFQ accelerator design for BNCT applications
Zhu, Xiaowen; Wang, Hu; Lu, Yuanrong; Wang, Zhi; Zhu, Kun; Zou, Yubin; Guo, Zhiyu
2018-03-01
Boron Neutron Capture Therapy (BNCT) promises a bright future in cancer therapy for its highly selective destruction of cancer cells, using the 10B +n→7Li +4 He reaction. It offers a more satisfactory therapeutic effect than traditional methods for the treatment of malignant brain tumors, head and neck cancer, melanoma, liver cancer and so on. A CW 4-vane RFQ, operating at 162.5 MHz, provides acceleration of a 20 mA proton beam to 2.5 MeV, bombarding a liquid lithium target for neutron production with a soft neutron energy spectrum. The fast neutron yield is about 1.73×1013 n/s. We preliminarily develop and optimize a beam shaping assembly design for the 7Li(p, n)7Be reaction with a 2.5 MeV proton beam. The epithermal neutron flux simulated at the beam port will reach up to 1 . 575 ×109 n/s/cm2. The beam dynamics design, simulation and benchmark for 2.5 MeV BNCT RFQ have been performed with both ParmteqM (V3.05) and Toutatis, with a transmission efficiency higher than 99.6% at 20 mA. To ease the thermal management in the CW RFQ operation, we adopt a modest inter-vane voltage design (U = 65 kV), though this does increase the accelerator length (reaching 5.2 m). Using the well-developed 3D electromagnetic codes, CST MWS and ANSYS HFSS, we are able to deal with the complexity of the BNCT RFQ, taking the contribution of each component in the RF volume into consideration. This allows us to optimize the longitudinal field distribution in a full-length model. Also, the parametric modeling technique is of great benefit to extensive modifications and simulations. In addition, the resonant frequency tuning of this RFQ is studied, giving the tuning sensitivities of vane channel and wall channel as -16.3 kHz/°C and 12.4 kHz/°C, respectively. Finally, both the multipacting level of this RFQ and multipacting suppressing in the coaxial coupler are investigated.
A novel design of beam shaping assembly to use D-T neutron generator for BNCT.
Kasesaz, Yaser; Karimi, Marjan
2016-12-01
In order to use 14.1MeV neutrons produced by d-T neutron generators, two special and novel Beam Shaping Assemblies (BSA), including multi-layer and hexagonal lattice have been suggested and the effect of them has been investigated by MCNP4C Monte Carlo code. The results show that the proposed BSA can provide the qualified epithermal neutron beam for BNCT. The final epithermal neutron flux is about 6e9 n/cm2.s. The final proposed BSA has some different advantages: 1) it consists of usual and well-known materials (Pb, Al, Fluental and Cd); 2) it has a simple geometry; 3) it does not need any additional gamma filter; 4) it can provide high flux of epithermal neutrons. As this type of neutron source is under development in the world, it seems that they can be used clinically in a hospital considering the proposed BSA. Copyright © 2016 Elsevier Ltd. All rights reserved.
International Nuclear Information System (INIS)
Rasouli, Fatemeh S.; Farhad Masoudi, S.; Kasesaz, Yaser
2012-01-01
Highlights: ► The possibility of using natural uranium as a neutron multiplier for D–T neutron generator is examined. ► To optimize output neutron beam, a moderator/filter/reflector arrangement was designed. ► The MCNP4C code has been used for BSA optimization and other simulations. ► The results show that using this system the BNCT in-air recommended parameters are met. - Abstract: Extensive research has recently been carried out for the development of high-energy D–T neutron generators as neutron sources for BNCT. The energy of these high-energy neutrons must be reduced by designing a Beam Shaping Assembly (BSA) to make them usable for BNCT. However, the neutron flux decreases drastically as neutrons pass through different materials of BSA. Therefore, it is very important to find ways to treat the neutrons economically. In this paper the possibility of using natural uranium as a neutron multiplier is investigated in order to increase the number of neutrons emitted from D–T neutron generator. According to the simulations and performed calculations, a sphere containing natural uranium as neutron multiplier was used to increase the number of neutrons generated by the D–T neutron generator. The energy of fast neutrons that are generated by D–T fusion reaction and amplified by neutron multiplier system is decreased using proper materials as moderators and fast neutron filters in BSA. The gamma rays which are generated as a result of neutron interaction with moderators are removed from neutron spectrum using bismuth as the gamma filter. Also, a thermal neutron absorber omits undesired low-energy neutrons which lead to a high radiation dose for the skin and soft tissues. The results show that passing neutrons through such a BSA causes the establishment of free beam parameters yet the reduction of the output beam intensity is unavoidable. The neutron spectrum related to our BSA has a proper epithermal flux and the fast and thermal neutron fluxes are
IRT-Sofia BNCT beam tube optimization study.
Belousov, S; Mitev, M; Ilieva, K; Riley, K; Harling, O
2011-12-01
An optimization study of IRT-Sofia BNCT beam tube is presented. In the study we used the MIT/FCB experience. The enlarging of filter/moderator cross section dimensions and the decreasing of collimator length within the limits of the IRT-Sofia reactor design were analyzed. The influence of beam and reactor core axes non-coincidence on the beam properties was also evaluated. The irradiation resistance of polytetrafluoroethylene (Teflon(®)) was also evaluated. The results provide information for making decisions on the IRT-Sofia BNCT beam construction. Copyright Â© 2011 Elsevier Ltd. All rights reserved.
Simulation of the BNCT of Brain Tumors Using MCNP Code: Beam Designing and Dose Evaluation
Directory of Open Access Journals (Sweden)
Fatemeh Sadat Rasouli
2012-09-01
Full Text Available Introduction BNCT is an effective method to destroy brain tumoral cells while sparing the healthy tissues. The recommended flux for epithermal neutrons is 109 n/cm2s, which has the most effectiveness on deep-seated tumors. In this paper, it is indicated that using D-T neutron source and optimizing of Beam Shaping Assembly (BSA leads to treating brain tumors in a reasonable time where all IAEA recommended criteria are met. Materials and Methods The proposed BSA based on a D-T neutron generator consists of a neutron multiplier system, moderators, reflector, and collimator. The simulated Snyder head phantom is used to evaluate dose profiles in tissues due to the irradiation of designed beam. Monte Carlo Code, MCNP-4C, was used in order to perform these calculations. Results The neutron beam associated with the designed and optimized BSA has an adequate epithermal flux at the beam port and neutron and gamma contaminations are removed as much as possible. Moreover, it was showed that increasing J/Φ, as a measure of beam directionality, leads to improvement of beam performance and survival of healthy tissues surrounding the tumor. Conclusion According to the simulation results, the proposed system based on D-T neutron source, which is suitable for in-hospital installations, satisfies all in-air parameters. Moreover, depth-dose curves investigate proper performance of designed beam in tissues. The results are comparable with the performances of other facilities.
CSIR Research Space (South Africa)
Du Plessis, WP
2009-10-01
Full Text Available A new synthesis procedure for interdigital filters with shorted-pin feeds is developed by relating the coupling factors and external Qs to the physical structure of the filter. This new procedure is easily understood and applied, extremely flexible...
Simplified design of filter circuits
Lenk, John
1999-01-01
Simplified Design of Filter Circuits, the eighth book in this popular series, is a step-by-step guide to designing filters using off-the-shelf ICs. The book starts with the basic operating principles of filters and common applications, then moves on to describe how to design circuits by using and modifying chips available on the market today. Lenk's emphasis is on practical, simplified approaches to solving design problems.Contains practical designs using off-the-shelf ICsStraightforward, no-nonsense approachHighly illustrated with manufacturer's data sheets
INEL BNCT Research Program annual report 1994
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R. [ed.
1995-11-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.
Tandem electrostatic accelerators for BNCT
International Nuclear Information System (INIS)
Ma, J.C.
1994-01-01
The development of boron neutron capture therapy (BNCT) into a viable therapeutic modality will depend, in part, on the availability of suitable neutron sources compatible with installation in a hospital environment. Low-energy accelerator-based intense neutron sources, using electrostatic or radio frequency quadrupole proton accelerators have been suggested for this purpose and are underdevelopment at several laboratories. New advances in tandem electrostatic accelerator technology now allow acceleration of the multi-milliampere proton beams required to produce therapeutic neutron fluxes for BNCT. The relatively compact size, low weight and high power efficiency of these machines make them particularly attractive for installation in a clinical or research facility. The authors will describe the limitations on ion beam current and available neutron flux from tandem accelerators relative to the requirements for BNCT research and therapy. Preliminary designs and shielding requirements for a tandern accelerator-based BNCT research facility will also be presented
A Comb Filter Design Method Using Linear Phase FIR Filter
Sugiura, Yosuke; Kawamura, Arata; Iiguni, Youji
This paper proposes a comb filter design method which utilizes two linear phase FIR filters for flexibly adjusting the comb filter's frequency response. The first FIR filter is used to individually adjust the notch gains, which denote the local minimum gains of the comb filter's frequency response. The second FIR filter is used to design the elimination bandwidths for individual notch gains. We also derive an efficient comb filter by incorporating these two FIR filters with an all-pass filter which is used in a conventional comb filter to accurately align the nulls with the undesired harmonic frequencies. Several design examples of the derived comb filter show the effectiveness of the proposed comb filter design method.
Rasouli, Fatemeh S; Masoudi, S Farhad
2012-12-01
A feasibility study was conducted to design a beam shaping assembly for BNCT based on D-T neutron generator. The optimization of this configuration has been realized in different steps. This proposed system consists of metallic uranium as neutron multiplier, TiF(3) and Al(2)O(3) as moderators, Pb as reflector, Ni as shield and Li-Poly as collimator to guide neutrons toward the patient position. The in-air parameters recommended by IAEA were assessed for this proposed configuration without using any filters which enables us to have a high epithermal neutron flux at the beam port. Also a simulated Snyder head phantom was used to evaluate dose profiles due to the irradiation of designed beam. The dose evaluation results and depth-dose curves show that the neutron beam designed in this work is effective for deep-seated brain tumor treatments even with D-T neutron generator with a neutron yield of 2.4×10(12) n/s. The Monte Carlo Code MCNP-4C is used in order to perform these calculations. Copyright © 2012 Elsevier Ltd. All rights reserved.
International Nuclear Information System (INIS)
Mohd Rafi Mohd Solleh; Abdul Aziz Tajuddin; Abdul Aziz Mohamed; Eid Mahmoud Eid Abdel Munem; Mohamad Hairie Rabir; Julia Abdul Karim; Yoshiaki, Kiyanagi
2011-01-01
The geometry of reactor core, thermal column, collimator and shielding system for BNCT application of TRIGA MARK II Reactor were simulated with MCNP5 code. Neutron particle lethargy and dose were calculated with MCNPX code. Neutron flux in a sample located at the end of collimator after normalized to measured value (Eid Mahmoud Eid Abdel Munem, 2007) at 1 MW power was 1.06 x 10 8 n/ cm 2 / s. According to IAEA (2001) flux of 1.00 x 10 9 n/ cm 2 / s requires three hours of treatment. Few modifications were needed to get higher flux. (Author)
INEL BNCT Research Program annual report, 1992
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R. [ed.
1993-05-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.
INEL BNCT Research Program annual report, 1992
International Nuclear Information System (INIS)
Venhuizen, J.R.
1993-05-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database
HF filter design and computer simulation
Rhea, Randall W
1994-01-01
A book for engineers who design and build filters of all types, including lumped element, coaxial, helical, dielectric resonator, stripline and microstrip types. A thorough review of classic and modern filter design techniques, containing extensive practical design information of passband characteristics, topologies and transformations, component effects and matching. An excellent text for the design and construction of microstrip filters.
Leukodepletion blood filters: filter design and mechanisms of leukocyte removal.
Dzik, S
1993-04-01
Modern leukocyte removal filters have been developed after years of refinement in design. Current filters are composite filters in which synthetic microfiber material is prepared as a nonwoven web. The filter material may be surface modified to alter surface tension or charge to improve performance. The housing design promotes effective contact of blood with the filter material and decreases shear forces. The exact mechanisms by which these filters remove leukocytes from blood components are uncertain, but likely represent a combination of both physical and biological processes whose contributions to leukocyte removal are interdependent. Small-pore microfiber webs result in barrier phenomena that permit retention of individual cells and increase the total adsorptive area of the filter. Modifications in surface charge can increase or decrease cell attraction to the fibers. Optimum interfacial surface tensions between blood cells, plasma, and filter fibers not only permit effective blood flow through small fiber pores, but also facilitate cell contact with the material. Barrier retention is a common mechanism for all modern leukocyte-removal filters and applies to all leukocyte subtypes. Because barrier retention does not depend on cell viability, it is operative for cells of any age and will retain any nondeformable cell, including whole nuclei from lymphocytes or monocytes. Barrier retention is supplemented by retention by adhesion. RBCs, lymphocytes, monocytes, granulocytes, and platelets differ in their relative adhesiveness to filter fibers. Different adhesive mechanisms are used in filters designed for RBCs compared with filters designed for platelets. Although lymphocytes, monocytes, and granulocytes can adhere directly to filter fibers, the biological mechanisms underlying cell adhesion may differ for these cell types. These differences may depend on expression of cell adhesion molecules. In the case of filtration of fresh RBCs, platelet-leukocyte interaction
Theory and design of microwave filters
Hunter, Ian
2000-01-01
This is a thorough, graduate-level text which provides a single source for filter design including basic circuit theory, network synthesis and the design of a variety of microwave filter structures. The aim is to present design theories followed by specific examples with numerical simulations of the designs, with pictures of real devices wherever possible. The book is aimed at designers, engineers and researchers working in microwave electronics who need to design or specify filters.
Filter and Filter Bank Design for Image Texture Recognition
Energy Technology Data Exchange (ETDEWEB)
Randen, Trygve
1997-12-31
The relevance of this thesis to energy and environment lies in its application to remote sensing such as for instance sea floor mapping and seismic pattern recognition. The focus is on the design of two-dimensional filters for feature extraction, segmentation, and classification of digital images with textural content. The features are extracted by filtering with a linear filter and estimating the local energy in the filter response. The thesis gives a review covering broadly most previous approaches to texture feature extraction and continues with proposals of some new techniques. 143 refs., 59 figs., 7 tabs.
Design and construction of electronic filters
International Nuclear Information System (INIS)
Becerril Z, E.R.; Moreno P, C.; Salinas B, E.
1979-01-01
The design and construction of very low frequencies electronic filters which will be used for carrying out analysis of pile noise at Mexico's Nuclear Center Triga Mark III Reactor, in order to realize measurements of its parameters is presented. NIM norms and active filters with lineal integrated circuits were used: a. Band pass filter from 10 to 500 hertz, band width 50. b. Low pass filter from 0.001 to 10 hertz in 3 steps. c. Kalman Bucy filter, an analogical simulation of this filter was undertaken, obtained from a mathematical model of a Zero power experimental reactor, with the purpose to establish a control searching. (author)
Performance analysis and design of filtering hydrocyclones
Directory of Open Access Journals (Sweden)
L. G. M. Vieira
2005-03-01
Full Text Available The filtering hydrocyclone is a solid-liquid separation device patented by the Chemical Engineering Department at the Federal University of Uberlândia, which consists of a hydrocyclone whose conical section was replaced by a conical filtering wall. The objective of this work is to compare the performances of the filtering hydrocyclones designed by Bradley and by Rietema. The experimental results obtained with the filtering hydrocyclones under the same operational conditions as those used with the conventional device allow the conclusion that performance of the Bradley and Rietema types is significantly influenced by the filtering medium. Rietema's filtering hydrocyclones had a lower volumetric feed flowrate than the conventional device and Bradley's filtering hydrocyclones showed increases in this same variable. In both designs, overall efficiency was influenced by the underflow-to-throughput ratio.
Kreiner, A J; Baldo, M; Bergueiro, J R; Cartelli, D; Castell, W; Thatar Vento, V; Gomez Asoia, J; Mercuri, D; Padulo, J; Suarez Sandin, J C; Erhardt, J; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Igarzabal, M; Minsky, D M; Herrera, M S; Capoulat, M E; Gonzalez, S J; del Grosso, M F; Gagetti, L; Suarez Anzorena, M; Gun, M; Carranza, O
2014-06-01
The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented. In particular, the present status and recent progress of the Argentine project will be reviewed. The topics will cover: intense ion sources, accelerator tubes, transport of intense beams, beam diagnostics, the (9)Be(d,n) reaction as a possible neutron source, Beam Shaping Assemblies (BSA), a treatment room, and treatment planning in realistic cases. © 2013 Elsevier Ltd. All rights reserved.
Analog Electronic Filters Theory, Design and Synthesis
Dimopoulos, Hercules G
2012-01-01
Filters are essential subsystems in a huge variety of electronic systems. Filter applications are innumerable; they are used for noise reduction, demodulation, signal detection, multiplexing, sampling, sound and speech processing, transmission line equalization and image processing, to name just a few. In practice, no electronic system can exist without filters. They can be found in everything from power supplies to mobile phones and hard disk drives and from loudspeakers and MP3 players to home cinema systems and broadband Internet connections. This textbook introduces basic concepts and methods and the associated mathematical and computational tools employed in electronic filter theory, synthesis and design. This book can be used as an integral part of undergraduate courses on analog electronic filters. Includes numerous, solved examples, applied examples and exercises for each chapter. Includes detailed coverage of active and passive filters in an independent but correlated manner. Emphasizes real filter...
Design of Kalman filters for mobile robots
DEFF Research Database (Denmark)
Larsen, Thomas Dall; Hansen, Karsten L.; Andersen, Nils Axel
1999-01-01
Kalman filters have for a long time been widely used on mobile robots as a location estimator. Many different Kalman filter designs have been proposed, using models of various complexity. In this paper, two different design methods are evaluated and compared. Focus is put on the common setup where...... the mobile robot is equipped with a dual encoder system supported by some additional absolute measurements. A common filter type for this setup is the odometric filter, where readings from the odometry system on the robot are used together with the geometry of the robot movement as a model of the robot....... If additional kinematic assumptions are made, for instance regarding the velocity of the robot, an augmented model can be used instead. This kinematic filter has some advantages when used intelligently, and it is shown how this type of filter can be used to suppress noise on encoder readings and velocity...
Neutron beams implemented at nuclear research reactors for BNCT
Bavarnegin, E.; Kasesaz, Y.; Wagner, F. M.
2017-05-01
This paper presents a survey of neutron beams which were or are in use at 56 Nuclear Research Reactors (NRRs) in order to be used for BNCT, either for treatment or research purposes in aspects of various combinations of materials that were used in their Beam Shaping Assembly (BSA) design, use of fission converters and optimized beam parameters. All our knowledge about BNCT is indebted to researches that have been done in NRRs. The results of about 60 years research in BNCT and also the successes of this method in medical treatment of tumors show that, for the development of BNCT as a routine cancer therapy method, hospital-based neutron sources are needed. Achieving a physical data collection on BNCT neutron beams based on NRRs will be helpful for beam designers in developing a non-reactor based neutron beam.
Design of Active N-path Filters
Darvishi, M.; van der Zee, Ronan A.R.; Nauta, Bram
2013-01-01
A design methodology for synthesis of active N-path bandpass filters is introduced. Based on this methodology, a 0.1-to-1.2 GHz tunable 6th-order N-path channel-select filter in 65 nm LP CMOS is introduced. It is based on coupling N-path filters with gyrators, achieving a “flat‿ passband shape and
BNCT with linac, feasibility study
International Nuclear Information System (INIS)
Alfuraih, A.; Ma, A.; Spyrou, N.M.; Awotwi-Pratt, Joseph
2006-01-01
High energy photon beams from Medical Linear Accelerators (linacs) which are used in radiotherapy produce undesirable neutrons, beside the clinically useful electron and photon beams. Neutrons are produced from the photonuclear reaction (γ,n) of high energy photons with high Z-materials which compose the accelerator head. In this paper the possible use of these undesirable neutrons for BNCT is investigated, making use of high energy linacs already installed in hospitals, primarily for high energy electron and photon therapy and applying them in the context of BNCT. The photoneutron components emitted by the accelerator is the source for Monte Carlo simulations of the interactions that take place within the head of a voxel-based phantom. The neutron flux across the phantom head is calculated using different moderator arrangements and different techniques in the aim of increasing the thermal neutron flux at the targeted site. Also, we shall test different configurations of the linac head to maximize the exposure of high-Z materials to the photon beam, including the removal of the flattening filter, so as to boost the photoneutron production in the linac head. Experimental work will be conducted in hospitals to validate the Monte Carlo simulations. To make use of linacs for BNCT will be advantageous in the sense that the setting in a hospital department is much more acceptable by the public than a reactor installation. This will mean less complications regarding patient positioning and movement with respect to the beams, additional patient transportation and management will be more cost effective. (author)
Ridge filter design for carbon radiotherapy
International Nuclear Information System (INIS)
Gata-Danil, G.; Parajpan, M.; Timoshenko, G.
2008-01-01
The design of a ridge filter intended for forming the uniform spread-out Bragg peak within a tumor at carbon radiotherapy is described. The computation of the ridge filter shape was carried out by an analytical algorithm and tested by MC simulation (GEANT4 code). Two kinds of the ridge filter were considered: stationary and movable. The influence on a ridge filter shape of the carbon beam energy and type of relative biological effectiveness dependence on the carbon ion linear energy transfer in tissue were examined
DESIGN IMPROVEMENT OF A LIQUID-MODERATOR-BASED NEUTRON SPECTROMETER FOR BNCT.
Tamaki, Shingo; Kusaka, Sachie; Sato, Fuminobu; Murata, Isao
2017-10-27
Boron neutron capture therapy is known to be an effective radiation cancer therapy that requires neutron irradiation. A neutron field generated by an accelerator-based neutron source has various energy spectra, and it is necessary to evaluate the neutron spectrum in the treatment field. However, the method used to measure the neutron spectrum in the treatment field is not well established. Many researchers are making efforts to improve the spectrometers. To solve this problem, we are developing a liquid-moderator-based neutron spectrometer that is based on the same theory as that of the Bonner sphere spectrometer. The spectrometer uses a liquid moderator and absorber. In the present study, we performed a design study to improve the previously developed liquid-moderator-based neutron spectrometer. By carrying out a numerical simulation of the designed new spectrometer, we finally assessed and confirmed the validity of this spectrometer numerically. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
International Nuclear Information System (INIS)
Padilla Cabal, F.; Martin, G.; Abrahantes, A.
2007-01-01
A monoenergetic neutron beam simulation study is carried out to determine the most suitable neutron energy for treatment of shallow and deep-seated brain tumors in the context of Boron Neutron Capture Therapy (BNCT). Two figures-of-merit, i.e. the absorbed dose for healthy tissue and the absorbed tumor dose at a given depth in the brain are used to measure the neutron beam quality. Also irradiation time, therapeutic gain and the power generated in the target are utilized as beam assessment parameters. Moderators, reflectors and delimiters are designed and optimized to moderate the high-energy neutrons from the fusion reactions 2 H(d;n) 3 He and 3 H(d;n) 4 Hedown to a suitable energy spectrum. Metallic uranium and manganese are successfully tested for fast-to-epithermal neutron moderation as well as Fluental TM for the neutron spectrum shifting. A semi spherical target is proposed in order to dissipate twice the amount of power generated in the target, and decrease all the dimensions of the BSA. The cooling system of the target is also included in the calculations. Calculations are performed using the MCNP code. After the optimization of our beam-shaper a study of the dose distribution in the head had been made. The therapeutic gain is increased in 9% while the current required for one hour treatment is decreased in comparison with the trading prototypes of NG used for BNCT. (Author)
International Nuclear Information System (INIS)
Padilla Cabal, F.; Martin, G; Abrahantes, A.
2007-01-01
A monoenergetic neutron beam simulation study is carried out to determine the most suitable neutron energy for treatment of shallow and deep-seated brain tumors in the context of Boron Neutron Capture Therapy (BNCT). Two figures-of-merit, i.e. the absorbed dose for healthy tissue and the absorbed tumor dose at a given depth in the brain are used to measure the neutron beam quality. Also irradiation time, therapeutic gain and the power generated in the target are utilized as beam assessment parameters. Moderators, reflectors and delimiters are designed and optimized to moderate the high-energy neutrons from the fusion reactions 2 H(d;n) 3 He and 3 H(d;n) 4 He down to a suitable energy spectrum. Metallic uranium and manganese are successfully tested for fast-to-epithermal neutron moderation as well as Fluental TM for the neutron spectrum shifting. A semispherical target is proposed in order to dissipate twice the amount of power generated in the target, and decrease all the dimensions of the BSA. The cooling system of the target is also included in the calculations. Calculations are performed using the MCNP code. After the optimization of our beam-shaper a study of the dose distribution in the head had been made. The therapeutic gain is increased in 9% while the current required for one hour treatment is decreased in comparison with the trading prototypes of NG used for BNCT. (Author)
High neutronic efficiency, low current targets for accelerator-based BNCT applications
International Nuclear Information System (INIS)
Powell, J.R.; Ludewig, H.; Todosow, M.
1998-01-01
The neutronic efficiency of target/filters for accelerator-based BNCT applications is measured by the proton current required to achieve a desirable neutron current at the treatment port (10 9 n/cm 2 /s). In this paper the authors describe two possible targeyt/filter concepts wihch minimize the required current. Both concepts are based on the Li-7 (p,n)Be-7 reaction. Targets that operate near the threshold energy generate neutrons that are close tothe desired energy for BNCT treatment. Thus, the filter can be extremely thin (∼ 5 cm iron). However, this approach has an extremely low neutron yield (n/p ∼ 1.0(-6)), thus requiring a high proton current. The proposed solutino is to design a target consisting of multiple extremely thin targets (proton energy loss per target ∼ 10 keV), and re-accelerate the protons between each target. Targets operating at ihgher proton energies (∼ 2.5 MeV) have a much higher yield (n/p ∼ 1.0(-4)). However, at these energies the maximum neutron energy is approximately 800 keV, and thus a neutron filter is required to degrade the average neutron energy to the range of interest for BNCT (10--20 keV). A neutron filter consisting of fluorine compounds and iron has been investigated for this case. Typically a proton current of approximately 5 mA is required to generate the desired neutron current at the treatment port. The efficiency of these filter designs can be further increased by incorporating neutron reflectors that are co-axial with the neutron source. These reflectors are made of materials which have high scattering cross sections in the range 0.1--1.0 MeV
Optimization of beam shaping assembly based on D-T neutron generator and dose evaluation for BNCT
Naeem, Hamza; Chen, Chaobin; Zheng, Huaqing; Song, Jing
2017-04-01
The feasibility of developing an epithermal neutron beam for a boron neutron capture therapy (BNCT) facility based on a high intensity D-T fusion neutron generator (HINEG) and using the Monte Carlo code SuperMC (Super Monte Carlo simulation program for nuclear and radiation process) is proposed in this study. The Monte Carlo code SuperMC is used to determine and optimize the final configuration of the beam shaping assembly (BSA). The optimal BSA design in a cylindrical geometry which consists of a natural uranium sphere (14 cm) as a neutron multiplier, AlF3 and TiF3 as moderators (20 cm each), Cd (1 mm) as a thermal neutron filter, Bi (5 cm) as a gamma shield, and Pb as a reflector and collimator to guide neutrons towards the exit window. The epithermal neutron beam flux of the proposed model is 5.73 × 109 n/cm2s, and other dosimetric parameters for the BNCT reported by IAEA-TECDOC-1223 have been verified. The phantom dose analysis shows that the designed BSA is accurate, efficient and suitable for BNCT applications. Thus, the Monte Carlo code SuperMC is concluded to be capable of simulating the BSA and the dose calculation for BNCT, and high epithermal flux can be achieved using proposed BSA.
American brain tumor patients treated with BNCT in Japan
International Nuclear Information System (INIS)
Laramore, G.E.; Griffin, B.R.; Spence, A.
1995-01-01
The purpose of this work is to establish and maintain a database for patients from the United States who have received BNCT in Japan for malignant gliomas of the brain. This database will serve as a resource for the DOE to aid in decisions relating to BNCT research in the United States, as well as assisting the design and implementation of clinical trials of BNCT for brain cancer patients in this country. The database will also serve as an information resource for patients with brain tumors and their families who are considering this form of therapy
International Nuclear Information System (INIS)
Ackermann, A.L.; Dorn, R.V. III.
1991-03-01
This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program for March 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, a milestone summary, and animal data charts
Energy Technology Data Exchange (ETDEWEB)
Ackermann, A.L. (ed.)
1991-08-01
This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Optimization of the irradiation beam in the BNCT research facility at IEA-R1 reactor
International Nuclear Information System (INIS)
Castro, Vinicius Alexandre de
2014-01-01
Boron Neutron Capture Therapy (BNCT) is a radiotherapeutic technique for the treatment of some types of cancer whose useful energy comes from a nuclear reaction that occurs when thermal neutron impinges upon a Boron-10 atom. In Brazil there is a research facility built along the beam hole number 3 of the IEA-R1 research reactor at IPEN, which was designed to perform BNCT research experiments. For a good performance of the technique, the irradiation beam should be mostly composed of thermal neutrons with a minimum as possible gamma and above thermal neutron components. This work aims to monitor and evaluate the irradiation beam on the sample irradiation position through the use of activation detectors (activation foils) and also to propose, through simulation using the radiation transport code, MCNP, new sets of moderators and filters which shall deliver better irradiation fields at the irradiation sample position In this work, a simulation methodology, based on a MCNP card, known as wwg (weight window generation) was studied, and the neutron energy spectrum has been experimentally discriminated at 5 energy ranges by using a new set o activation foils. It also has been concluded that the BNCT research facility has the required thermal neutron flux to perform studies in the area and it has a great potential for improvement for tailoring the irradiation field. (author)
Design and application of finite impulse response digital filters.
Miller, T R; Sampathkumaran, K S
1982-01-01
The finite impulse response (FIR) digital filter is a spatial domain filter with a frequency domain representation. The theory of the FIR filter is presented and techniques are described for designing FIR filters with known frequency response characteristics. Rational design principles are emphasized based on characterization of the imaging system using the modulation transfer function and physical properties of the imaged objects. Bandpass, Wiener, and low-pass filters were designed and applied to 201Tl myocardial images. The bandpass filter eliminates low-frequency image components that represent background activity and high-frequency components due to noise. The Wiener, or minimum mean square error filter 'sharpens' the image while also reducing noise. The Wiener filter illustrates the power of the FIR technique to design filters with any desired frequency response. The low-pass filter, while of relative limited use, is presented to compare it with a popular elementary 'smoothing' filter.
Higher Order Output Filter Design for Grid Connected Power Converters.
Parikshith, BC; John, Vinod
2008-01-01
Design of higher order LCL filters that are used in grid-connected inverter applications involves multiple constraints. The filter requirements are driven by tight filtering tolerances of standards such as IEEE 519-1992 and IEEE P1547.2- 2003. Higher order LCL filters are essential to achieve these regulatory standard requirements at compact size and weight. This paper discusses the design procedure for these higher order LCL filters. The design procedure is analysed in per-unit basis so resu...
An Accelerator Neutron Source for BNCT
International Nuclear Information System (INIS)
Blue, Thomas E.
2006-01-01
The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were (1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, (2) that the patient treatment time be reasonable, (3) that the proton current required to treat patients in reasonable times be technologically achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally (4) that the treatment be safe for the patients
An Accelerator Neutron Source for BNCT
Energy Technology Data Exchange (ETDEWEB)
Blue, Thomas, E
2006-03-14
The overall goal of this project was to develop an accelerator-based neutron source (ABNS) for Boron Neutron Capture Therapy (BNCT). Specifically, our goals were to design, and confirm by measurement, a target assembly and a moderator assembly that would fulfill the design requirements of the ABNS. These design requirements were 1) that the neutron field quality be as good as the neutron field quality for the reactor-based neutron sources for BNCT, 2) that the patient treatment time be reasonable, 3) that the proton current required to treat patients in reasonable times be technologially achievable at reasonable cost with good reliability, and accelerator space requirements which can be met in a hospital, and finally 4) that the treatment be safe for the patients.
FILTSoft: A computational tool for microstrip planar filter design
Elsayed, M. H.; Abidin, Z. Z.; Dahlan, S. H.; Cholan N., A.; Ngu, Xavier T. I.; Majid, H. A.
2017-09-01
Filters are key component of any communication system to control spectrum and suppress interferences. Designing a filter involves long process as well as good understanding of the basic hardware technology. Hence this paper introduces an automated design tool based on Matlab-GUI, called the FILTSoft (acronym for Filter Design Software) to ease the process. FILTSoft is a user friendly filter design tool to aid, guide and expedite calculations from lumped elements level to microstrip structure. Users just have to provide the required filter specifications as well as the material description. FILTSoft will calculate and display the lumped element details, the planar filter structure, and the expected filter's response. An example of a lowpass filter design was calculated using FILTSoft and the results were validated through prototype measurement for comparison purposes.
Frequency and amplitude normalization and filter design | Onuu ...
African Journals Online (AJOL)
... describes the relationship between the transition bandwidth and the parameter that determines the selectivity of the filter for each of the windows. Some characteristics have been calculated for the designed and constructed filters. Keywords: normalization, filter design, windows and windowing. Nigerian Journal of Physics ...
BNCT irradiation facility at the JRR-4
International Nuclear Information System (INIS)
Torii, Y.; Kishi, T.; Kumada, H.; Yamamoto, K.; Sakurai, F.; Takayanagi, M.
2000-01-01
The JRR--4 was modified for fuel enrichment reducing and reactor equipment renewal. And also a medical irradiation facility for the Boron Neutron Capture Therapy (BNCT) was installed at the JRR--4 in that time. The medical irradiation facility has been composed of a heavy water tank, a collimator and an irradiation room. The heavy water tank has four layers of heavy water for spectrum shifter and 75cm-thickness aluminum for the shield of fast neutron. The collimator is for collimating thermal neutron and epithermal neutron using polyethylene with lithium-fluoride and shielding gamma ray by bismuth. The irradiation room has sufficient space at exit side of the beam, to accommodate a large working area for setting the patient. Both of the medical treatment room and the patient-monitoring area were prepared adjacent to the irradiation room. The medical irradiation facility in the JRR-4 is designed to permit selection of neutron energies from thermal neutron to epithermal neutron by changing the thickness of heavy water layers. Therefore it is available to continue the same kind of BNCT with thermal neutron used to perform in the JRR-2, as well as to commence the research and development of BNCT with epithermal neutron, which will make the brain tumor treatment possible at a deep part of brain. The full power operation of the JRR-4 was resumed with LEU fuel in October 1998 and currently performing some experiments to measure the neutron fluxes and physical doses for determinate characterization of the medical irradiation facility. The first medical irradiation for BNCT was carried out on 25th October 1999. The patient was treated by Tsukuba University group using thermal neutron beam included epi-thermal neutrons. (author)
BNCT irradiation facility at the JRR-4
Energy Technology Data Exchange (ETDEWEB)
Torii, Y.; Kishi, T.; Kumada, H.; Yamamoto, K.; Sakurai, F.; Takayanagi, M. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment
2000-10-01
The JRR--4 was modified for fuel enrichment reducing and reactor equipment renewal. And also a medical irradiation facility for the Boron Neutron Capture Therapy (BNCT) was installed at the JRR--4 in that time. The medical irradiation facility has been composed of a heavy water tank, a collimator and an irradiation room. The heavy water tank has four layers of heavy water for spectrum shifter and 75cm-thickness aluminum for the shield of fast neutron. The collimator is for collimating thermal neutron and epithermal neutron using polyethylene with lithium-fluoride and shielding gamma ray by bismuth. The irradiation room has sufficient space at exit side of the beam, to accommodate a large working area for setting the patient. Both of the medical treatment room and the patient-monitoring area were prepared adjacent to the irradiation room. The medical irradiation facility in the JRR-4 is designed to permit selection of neutron energies from thermal neutron to epithermal neutron by changing the thickness of heavy water layers. Therefore it is available to continue the same kind of BNCT with thermal neutron used to perform in the JRR-2, as well as to commence the research and development of BNCT with epithermal neutron, which will make the brain tumor treatment possible at a deep part of brain. The full power operation of the JRR-4 was resumed with LEU fuel in October 1998 and currently performing some experiments to measure the neutron fluxes and physical doses for determinate characterization of the medical irradiation facility. The first medical irradiation for BNCT was carried out on 25th October 1999. The patient was treated by Tsukuba University group using thermal neutron beam included epi-thermal neutrons. (author)
Multispectral filter array design without training images
Shinoda, Kazuma; Yanagi, Yudai; Hayasaki, Yoshio; Hasegawa, Madoka
2017-08-01
Multispectral images (MSIs) have been studied for many applications; however, limitations persist in techniques to capture them due to the complexity of assembling one or more prisms and multiple sensor arrays in order to detect signals. Inspired by the application of color filter arrays to commercial digital RGB cameras, a number of researchers have studied multispectral filter arrays (MSFAs) to solve this problem. Determining the measurement wavelength and pattern of an MSFA is important for improving the quality of the demosaicked image. Some conventional studies for designing MSFAs have used training data and have optimized the measurement wavelengths and the pattern by iteratively minimizing the error between the training data and the demosaicked images. We propose a metric to evaluate an MSFA without MSIs, and optimize the measurement wavelengths and the pattern of the MSFA by minimizing the metric. The proposed metric measures the sampling distance between filters in a spatial-spectral domain and quantifies the dispersion of the sampling points by average nearest-neighbor distance (ANND) under a given arbitrary MSFA. Since the quality of the demosaicked image is assumed to be proportional to the degree of dispersion of the sampling points in the spatial-spectral domain, we optimize the MSFA by minimizing the ANND in a nested simulated annealing process. Experimental results show that the optimized MSFA obtained using our method attained a higher peak signal-to-noise ratio (PSNR) than conventional untrained MSFAs in many cases. In addition, the performance difference between some trained MSFAs and the proposed MSFA was small. We also confirmed the validity of the proposed ANND by a comparison with the mean square error obtained from MSI datasets.
Media filter drain : modified design evaluation.
2014-09-01
The media filter drain (MFD), a stormwater water quality treatment best management practice, consists of media made up of : aggregate, perlite, gypsum and dolomite in a trench located along roadway shoulders with gravel and vegetative pre-filtering f...
Design and fabrication of magnetic coolant filter
Prashanth, B. N.
2017-07-01
Now a day's use of coolants in industry has become dominant because of high production demands. Coolants not only help in speeding up the production but also provide many advantages in the metal working operation. As the consumption of coolants is very high a system is badly in need, so as to recirculate the used coolant. Also the amount of hazardous waste generated by industrial plants has become an increasingly costly problem for the manufactures and an additional stress on the environment. Since the purchase and disposal of the spent cutting fluids is becoming increasingly expensive, fluid recycling is a viable option for minimizing the cost. Separation of metallic chips from the coolants by using magnetic coolant separation has proven a good management and maintenance of the cutting fluid. By removing the metallic chips, the coolant life is greatly extended, increases the machining quality and reduces downtime. Above being the case, a magnetic coolant filter is developed which utilizes high energy permanent magnets to develop a dense magnetic field along a narrow flow path into which the contaminated coolant is directed. The ferromagnetic particles captured and aligned by the dense magnetic field, from the efficient filter medium. This enables the unit to remove ferromagnetic particles from the coolant. Magnetic coolant filters use the principle of magnetic separation to purify the used coolant. The developed magnetic coolant separation has the capability of purifying 40 litres per minute of coolant with the size of the contaminants ranging from 1 µm to 30 µm. The filter will be helpful in saving the production cost as the cost associated with the proposed design is well justified by the cost savings in production. The magnetic field produced by permanent magnets will be throughout the area underneath the reservoir. This produces magnetic field 30mm above the coolant reservoir. Very fine particles are arrested without slip. The magnetic material used will not
Michelson interferometer based interleaver design using classic IIR filter decomposition.
Cheng, Chi-Hao; Tang, Shasha
2013-12-16
An elegant method to design a Michelson interferometer based interleaver using a classic infinite impulse response (IIR) filter such as Butterworth, Chebyshev, and elliptic filters as a starting point are presented. The proposed design method allows engineers to design a Michelson interferometer based interleaver from specifications seamlessly. Simulation results are presented to demonstrate the validity of the proposed design method.
Frequency weighting filter design for automotive ride comfort evaluation
Du, Feng
2016-07-01
Few study gives guidance to design weighting filters according to the frequency weighting factors, and the additional evaluation method of automotive ride comfort is not made good use of in some countries. Based on the regularities of the weighting factors, a method is proposed and the vertical and horizontal weighting filters are developed. The whole frequency range is divided several times into two parts with respective regularity. For each division, a parallel filter constituted by a low- and a high-pass filter with the same cutoff frequency and the quality factor is utilized to achieve section factors. The cascading of these parallel filters obtains entire factors. These filters own a high order. But, low order filters are preferred in some applications. The bilinear transformation method and the least P-norm optimal infinite impulse response(IIR) filter design method are employed to develop low order filters to approximate the weightings in the standard. In addition, with the window method, the linear phase finite impulse response(FIR) filter is designed to keep the signal from distorting and to obtain the staircase weighting. For the same case, the traditional method produces 0.330 7 m • s-2 weighted root mean square(r.m.s.) acceleration and the filtering method gives 0.311 9 m • s-2 r.m.s. The fourth order filter for approximation of vertical weighting obtains 0.313 9 m • s-2 r.m.s. Crest factors of the acceleration signal weighted by the weighting filter and the fourth order filter are 3.002 7 and 3.011 1, respectively. This paper proposes several methods to design frequency weighting filters for automotive ride comfort evaluation, and these developed weighting filters are effective.
Design of Microwave Multibandpass Filters with Quasilumped Resonators
Directory of Open Access Journals (Sweden)
Dejan Miljanović
2015-01-01
Full Text Available Design of RF and microwave filters has always been the challenging engineering field. Modern filter design techniques involve the use of the three-dimensional electromagnetic (3D EM solvers for predicting filter behavior, yielding the most accurate filter characteristics. However, the 3D EM simulations are time consuming. In this paper, we propose electric-circuit models, instead of 3D EM models, suitable for design of RF and microwave filters with quasilumped coupled resonators. Using the diakoptic approach, the 3D filter structure is decomposed into domains that are modeled by electric networks. The coupling between these domains is modeled by capacitors and coupled inductors. Furthermore, we relate the circuit-element values to the physical dimensions of the 3D filter structure. We propose the filter design procedure that is based on the circuit models and fast circuit-level simulations, yielding the element values from which the physical dimensions can be obtained. The obtained dimensions should be slightly refined for achieving the desired filter characteristics. The mathematical problems encountered in the procedure are solved by numerical and symbolic computations. The procedure is exemplified by designing a triple-bandpass filter and validated by measurements on the fabricated filter. The simulation and experimental results are in good agreement.
Design of minimum entropy wavelet filters using genetic algorithms
Jasper, Warren J.; Joines, Jeff
2005-11-01
This paper presents a method to design a wavelet-filter that minimizes entropy in the wavelet transform. Filters that minimize entropy in images tend to filter out texture while highlighting features of interest. The design of the wavelet filter is couched as a non-convex optimization problem which is solved using a hybridized Genetic Algorithm. As an example, three distinct filters are tuned to detect horizontal, vertical and blob defects in woven fabrics. The effects of shifting on the optimized set of coefficients is also explored.
Design and control of LCL-filter with active damping for Active Power Filter
DEFF Research Database (Denmark)
Zeng, Guohong; Rasmussen, Tonny Wederberg; Ma, L
2010-01-01
In the application of shunt Active Power Filter (APF) to compensate nonlinear load's harmonic, reactive and negative sequence current, it is more effective to use a LCL-filter than an L-filter as an interface between the Voltage Source Converter (VSC) and grid. In this paper, a designing procedure...... of LCL-filter for APF is introduced, which is aimed for simplified the implementation. To suppress the resonance that may be excited in the system, which brings in stability problems, an active damping control strategy using the current feed-back of the filter capacitor is adopted. By selecting two equal...... or similar inductances, the filter designing become more simple and effective, meanwhile the capacitance requirement is minimized. A pole-zero automatic cancellation phenomenon is discussed in this paper, which can be applied to simplify the current regulator designing. The tuning method is presented, based...
INEEL BNCT Research Program Annual Report, CY-2000
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, James Robert
2001-03-01
This report is a summary of the activities conducted in conjunction with the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 2000. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, neutron source design and demonstration, and support the Department of Energy’s (DOE) National BNCT Program goals are the goals of this Program. Contributions from the individual contributors about their projects are included, specifically described are the following, chemistry: analysis of biological samples and an infrared blood-boron analyzer, and physics: progress in the patient treatment planning software, measurement of neutron spectra for the Argentina RA-6 reactor, and recalculation of the Finnish research reactor FiR 1 neutron spectra, BNCT accelerator technology, and modification to the research reactor at Washington State University for an epithermal-neutron beam.
Noniterative Design of 2-Channel FIR Orthogonal Filters
Directory of Open Access Journals (Sweden)
Jiménez M Elena Domínguez
2007-01-01
Full Text Available This paper addresses the problem of obtaining an explicit expression of all real FIR paraunitary filters. In this work, we present a general parameterization of 2-channel FIR orthogonal filters. Unlike other approaches which make use of a lattice structure, we show that our technique designs any orthogonal filter directly, with no need of iteration procedures. Moreover, in order to design an -tap 2-channel paraunitary filterbank, it suffices to choose independent parameters, and introduce them in a simple expression which provides the filter coefficients directly. Some examples illustrate how this new approach can be used for designing filters with certain desired properties. Further conditions can be eventually imposed on the parameters so as to design filters for specific applications.
Noniterative Design of 2-Channel FIR Orthogonal Filters
Directory of Open Access Journals (Sweden)
M. Elena Domínguez Jiménez
2007-01-01
Full Text Available This paper addresses the problem of obtaining an explicit expression of all real FIR paraunitary filters. In this work, we present a general parameterization of 2-channel FIR orthogonal filters. Unlike other approaches which make use of a lattice structure, we show that our technique designs any orthogonal filter directly, with no need of iteration procedures. Moreover, in order to design an L-tap 2-channel paraunitary filterbank, it suffices to choose L/2 independent parameters, and introduce them in a simple expression which provides the filter coefficients directly. Some examples illustrate how this new approach can be used for designing filters with certain desired properties. Further conditions can be eventually imposed on the parameters so as to design filters for specific applications.
Generalized design of high performance shunt active power filter with output LCL filter
DEFF Research Database (Denmark)
Tang, Yi; Loh, Poh Chiang; Wang, Peng
2012-01-01
, the proposed SAPF offers superior switching harmonic suppression using much reduced passive filtering elements. Its output currents thus have high slew rate for tracking the targeted reference closely. Smaller inductance of the LCL filter also means smaller harmonic voltage drop across the passive output......This paper concentrates on the design, control, and implementation of an LCL-filter-based shunt active power filter (SAPF), which can effectively compensate for harmonic currents produced by nonlinear loads in a three-phase three-wire power system. With an LCL filter added at its output...... filter, which in turn minimizes the possibility of overmodulation, particularly for cases where high modulation index is desired. These advantages, together with overall system stability, are guaranteed only through proper consideration of critical design and control issues, like the selection of LCL...
Tunable Microwave Filter Design Using Thin-Film Ferroelectric Varactors
Haridasan, Vrinda
Military, space, and consumer-based communication markets alike are moving towards multi-functional, multi-mode, and portable transceiver units. Ferroelectric-based tunable filter designs in RF front-ends are a relatively new area of research that provides a potential solution to support wideband and compact transceiver units. This work presents design methodologies developed to optimize a tunable filter design for system-level integration, and to improve the performance of a ferroelectric-based tunable bandpass filter. An investigative approach to find the origins of high insertion loss exhibited by these filters is also undertaken. A system-aware design guideline and figure of merit for ferroelectric-based tunable band- pass filters is developed. The guideline does not constrain the filter bandwidth as long as it falls within the range of the analog bandwidth of a system's analog to digital converter. A figure of merit (FOM) that optimizes filter design for a specific application is presented. It considers the worst-case filter performance parameters and a tuning sensitivity term that captures the relation between frequency tunability and the underlying material tunability. A non-tunable parasitic fringe capacitance associated with ferroelectric-based planar capacitors is confirmed by simulated and measured results. The fringe capacitance is an appreciable proportion of the tunable capacitance at frequencies of X-band and higher. As ferroelectric-based tunable capac- itors form tunable resonators in the filter design, a proportionally higher fringe capacitance reduces the capacitance tunability which in turn reduces the frequency tunability of the filter. Methods to reduce the fringe capacitance can thus increase frequency tunability or indirectly reduce the filter insertion-loss by trading off the increased tunability achieved to lower loss. A new two-pole tunable filter topology with high frequency tunability (> 30%), steep filter skirts, wide stopband
International Nuclear Information System (INIS)
Mitin, V.N.; Kulakov, V.N.; Khokhlov, V.F.
2006-01-01
A dog was diagnosed with osteosarcoma (8x6x5cm) in the right wing of ilium by radiography, radionuclide scintigraphy and histological study of biopsy material. The treatment plan was as follows: γ-therapy in combination with chemotherapy; prevention of hematogenous pulmonary metastases by the transfusion of 130 ml of allogenic marrow from a healthy donor; administration of 11.4g 10 B-boronphenylalanine into the right iliac artery; resection of the right iliac wing with the osteosarcoma lesion; neutron irradiation (MEPhI Reactor) of the bone fragment (dose on healthy osteocytes - 15±4 Gy (W), on tumor - 50±9 Gy (W); reimplantation and fixation of the fragment; three courses of adjuvant chemotherapy. The doses were determined in full-scale calculations of the reactor radiation fields with a model of the bone under the code RADUGA. The 10 B concentration (μg/g) in the bone was: normal tissue - 9±3, tumor - 28±5. In 24 hours post operation the dog was able to walk using the treated limb, and 6 months later it moved freely. The patient has been under observation for 30 months. The results of the research demonstrate complete cure. The use of similar treatment plans improves the therapeutic efficiency of BNCT. (author)
Electrically heated particulate filter embedded heater design
Gonze, Eugene V.; Chapman, Mark R.
2014-07-01
An exhaust system that processes exhaust generated by an engine is provided. The system generally includes a particulate filter (PF) that filters particulates from the exhaust wherein an upstream end of the PF receives exhaust from the engine and wherein an upstream surface of the particulate filter includes machined grooves. A grid of electrically resistive material is inserted into the machined grooves of the exterior upstream surface of the PF and selectively heats exhaust passing through the grid to initiate combustion of particulates within the PF.
Mandal, S.; Bakeine, G.J.; Krol, S.; Ferrari, C.; Clerici, A.M.; Zonta, C.; Cansolino, L.; Ballarini, F.; Bortolussi, S.; Stella, S.; Protti, N.; Bruschi, P.; Altieri, S.
2011-01-01
The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were
Design of an emi output filter for frequency converters
Roc'h, A.; Bergsma, J.G.; Bergsma, H.; Leferink, Frank Bernardus Johannes; Zhao, D.; Polinder, H.; Ferreira, B.
2006-01-01
A filter has been designed to reduce conducted and radiated emission generated by a frequency converter. The frequency converter, cables and motor were modelled in order to make a good estimation of the radiated emission. A single stage output filter was designed making use of feedthrough apacitors
Design of Dual Bandpass and Bandreject LC Ladder Filters
Directory of Open Access Journals (Sweden)
J. Hospodka
2006-09-01
Full Text Available This paper deals with the design of two-passband bandpass and two-stopband bandreject LC ladder filters. The design method is based on the special dual frequency transformation that transforms normalized lowpass to either bandpass with two passbands or to bandreject with two stopbands that are specified by four cutoff frequencies. The paper shows analytical solution relating these four cutoff frequencies to parameters of dual frequency transformation. It enables a direct computation of dual band LC filter elements from a normalized lowpass filter by means of simple relations. These relations have been implemented in the mathematical program Maple (TM as new user functions. They are supposed to be used as an enhancement of Syntfil package which is intended for analog filter design in program Maple. Specific application is shown on an example of the two-passband bandpass LC filter design.
Digital Modem Design Based on Multirate Filter Banks
Sadr, R.; Raphaeli, D.; Hinedi, S.
1994-01-01
A new approach for the architecture of an all digital modem design is presented. The key feature is a lower processing rate than that of the Nyquist rate (the input sampling rate) and even the symbol rate. The lower processing rate is achieved by the use of a parallel structure, based on multirate filter banks concepts. In this proposed scheme, matched filtering is implemented in the subbands of an analysis/synthesis filter bank.
Design, control, and implementation of LCL-filter-based shunt active power filters
DEFF Research Database (Denmark)
Tang, Yi; Loh, Poh Chiang; Wang, Peng
2011-01-01
superior switching harmonic suppression with much reduced size of passive filtering elements. This allows SAPF to generate high slew rate output currents that can closely track the targeted reference. Moreover, smaller inductance directly translates into less harmonic voltage drop on the passive output......This paper concentrates on the design, control and implementation of an LCL-filter-based shunt active power filter (SAPF), which can effectively compensate harmonic currents produced by nonlinear loads in a three-phase three-wire power system. The use of LCL-filter at the output end of SAPF offers...... filter, which can minimize the possibility of over modulation, especially for relatively low dc-link voltage (or high modulation index) of SAPF. Some critical issues, like selection of LCL parameters, interactions between resonance damping and harmonic compensation, bandwidth design of closed...
Filter design for molecular factor computing using wavelet functions.
Li, Xiaoyong; Xu, Zhihong; Cai, Wensheng; Shao, Xueguang
2015-06-23
Molecular factor computing (MFC) is a new strategy that employs chemometric methods in an optical instrument to obtain analytical results directly using an appropriate filter without data processing. In the present contribution, a method for designing an MFC filter using wavelet functions was proposed for spectroscopic analysis. In this method, the MFC filter is designed as a linear combination of a set of wavelet functions. A multiple linear regression model relating the concentration to the wavelet coefficients is constructed, so that the wavelet coefficients are obtained by projecting the spectra onto the selected wavelet functions. These wavelet functions are selected by optimizing the model using a genetic algorithm (GA). Once the MFC filter is obtained, the concentration of a sample can be calculated directly by projecting the spectrum onto the filter. With three NIR datasets of corn, wheat and blood, it was shown that the performance of the designed filter is better than that of the optimized partial least squares models, and commonly used signal processing methods, such as background correction and variable selection, were not needed. More importantly, the designed filter can be used as an MFC filter in designing MFC-based instruments. Copyright © 2015 Elsevier B.V. All rights reserved.
Contourlet Filter Design Based on Chebyshev Best Uniform Approximation
Directory of Open Access Journals (Sweden)
Ming Hou
2010-01-01
Full Text Available The contourlet transform can deal effectively with images which have directional information such as contour and texture. In contrast to wavelets for which there exists many good filters, the contourlet filter design for image processing applications is still an ongoing work. Therefore, this paper presents an approach for designing the contourlet filter based on the Chebyshev best uniform approximation for achieving an efficient image denoising applications using hidden Markov tree models in the contourlet domain. Here, we design both the optimal 9/7 wavelet filter banks with rational coefficients and new pkva 12 filter. In this paper, the Laplacian pyramid followed by the direction filter banks decomposition in the contourlet transform using the two filter banks above and the image denoising applications in the contourlet hidden Markov tree model are implemented, respectively. The experimental results show that the denoising performance of the test image Zelda in terms of peak signal-to-noise ratio is improved by 0.33 dB than using CDF 9/7 filter banks with irrational coefficients on the JPEG2000 standard and standard pkva 12 filter, and visual effects are as good as compared with the research results of Duncan D.-Y. Po and Minh N. Do.
Contourlet Filter Design Based on Chebyshev Best Uniform Approximation
Directory of Open Access Journals (Sweden)
Fang Xiaofeng
2010-01-01
Full Text Available Abstract The contourlet transform can deal effectively with images which have directional information such as contour and texture. In contrast to wavelets for which there exists many good filters, the contourlet filter design for image processing applications is still an ongoing work. Therefore, this paper presents an approach for designing the contourlet filter based on the Chebyshev best uniform approximation for achieving an efficient image denoising applications using hidden Markov tree models in the contourlet domain. Here, we design both the optimal 9/7 wavelet filter banks with rational coefficients and new pkva 12 filter. In this paper, the Laplacian pyramid followed by the direction filter banks decomposition in the contourlet transform using the two filter banks above and the image denoising applications in the contourlet hidden Markov tree model are implemented, respectively. The experimental results show that the denoising performance of the test image Zelda in terms of peak signal-to-noise ratio is improved by 0.33 dB than using CDF 9/7 filter banks with irrational coefficients on the JPEG2000 standard and standard pkva 12 filter, and visual effects are as good as compared with the research results of Duncan D.-Y. Po and Minh N. Do.
International Nuclear Information System (INIS)
Pozzi, E.C.C.; Curotto, P.; Monti Hughes, A.; Nigg, D.W.; Schwint, A.E.; Trivillin, V.A.; Thorp, S.I.
2013-01-01
Our research group at the Radiation Pathology Division of the Department of Radiobiology (National Atomic Energy Commission) has previously demonstrated the therapeutic efficacy of different BNCT protocols to treat oral cancer in an experimental hamster cheek pouch model. In particular, to perform studies in this experimental model at the thermal facility constructed at RA-3, we designed and constructed a shielding device for thermal neutrons, to be able to expose the cheek pouch while minimizing the dose to the rest of the body. This device allowed for the irradiation of one animal at a time. Given the usage rate of the device, the aim of the present study was to design and construct an optimized version of the existing shielding device that would allow for the simultaneous irradiation of 2 animals at the thermal facility of RA-3. Taking into account the characteristics of the neutron source and preliminary biological assays, we designed the shielding device for the body of the animal, i.e. a rectangular shaped box with double acrylic walls. The space between the walls contains a continuous filling of 6Li 2 CO 3 (95% enriched in 6Li), approximately 6 mm thick. Two small windows interrupt the shield at one end of the box through which the right pouch of each hamster is everted out onto an external acrylic shelf for exposure to the neutron flux. The characterization of the shielding device showed that the neutron flux was equivalent at both irradiation positions confirming that we were able to design and construct a new shielding device that allows for the irradiation of 2 animals at the same time at the thermal facility of RA-3. This new version of the shielding device will reduce the number of interventions of the reactor operators, reducing occupational exposure to radiation and will make the procedure more efficient for researchers. In addition, we addressed the generation of tritium as a product of the capture reaction in lithium. It was considered as a
Special design of an electric filter
International Nuclear Information System (INIS)
Tiesler, H.
1979-01-01
The wet electric filter to clean champ waste gases is characterized in that the separation electrodes are at the same time cooling surfaces. The transport of the coolant through the tubes forming the cooling channel is performed by means of mechanical convergence, the heat transport by convection. (GL) [de
Modern analog filter analysis and design a practical approach
Raut, R
2011-01-01
Starting from the fundamentals, the present book describes methods of designing analog electronic filters and illustrates these methods by providing numerical and circuit simulation programs. The subject matters comprise many concepts and techniques that are not available in other text books on the market. To name a few - principle of transposition and its application in directly realizing current mode filters from well known voltage mode filters; an insight into the technological aspect of integrated circuit components used to implement an integrated circuit filter; a careful blending of basi
Low-complexity wavelet filter design for image compression
Majani, E.
1994-01-01
Image compression algorithms based on the wavelet transform are an increasingly attractive and flexible alternative to other algorithms based on block orthogonal transforms. While the design of orthogonal wavelet filters has been studied in significant depth, the design of nonorthogonal wavelet filters, such as linear-phase (LP) filters, has not yet reached that point. Of particular interest are wavelet transforms with low complexity at the encoder. In this article, we present known and new parameterizations of the two families of LP perfect reconstruction (PR) filters. The first family is that of all PR LP filters with finite impulse response (FIR), with equal complexity at the encoder and decoder. The second family is one of LP PR filters, which are FIR at the encoder and infinite impulse response (IIR) at the decoder, i.e., with controllable encoder complexity. These parameterizations are used to optimize the subband/wavelet transform coding gain, as defined for nonorthogonal wavelet transforms. Optimal LP wavelet filters are given for low levels of encoder complexity, as well as their corresponding integer approximations, to allow for applications limited to using integer arithmetic. These optimal LP filters yield larger coding gains than orthogonal filters with an equivalent complexity. The parameterizations described in this article can be used for the optimization of any other appropriate objective function.
Design Procedure for Compact Folded Waveguide Filters
DEFF Research Database (Denmark)
Dong, Yunfeng; Johansen, Tom Keinicke; Zhurbenko, Vitaliy
Waveguide filters are widely used in communication systems due to low losses and high power handling capabilities. One drawback of the conventional waveguide filters is their large size, especially for low-frequency and high-order realizations. It has been shown that the footprint of conventional....... The insertion loss in the pass-band (1.54 GHz – 1.56 GHz) is specified to be less than 1 dB while the return loss should be more than 18 dB. The isolation in the rejection-band (1.58 GHz – 1.60 GHz) is required to be more than 45 dB. The coupling matrix synthesis is introduced first and a two-layer realization...
Efficient Algorithms and Design for Interpolation Filters in Digital Receiver
Directory of Open Access Journals (Sweden)
Xiaowei Niu
2014-05-01
Full Text Available Based on polynomial functions this paper introduces a generalized design method for interpolation filters. The polynomial-based interpolation filters can be implemented efficiently by using a modified Farrow structure with an arbitrary frequency response, the filters allow many pass- bands and stop-bands, and for each band the desired amplitude and weight can be set arbitrarily. The optimization coefficients of the interpolation filters in time domain are got by minimizing the weighted mean squared error function, then converting to solve the quadratic programming problem. The optimization coefficients in frequency domain are got by minimizing the maxima (MiniMax of the weighted mean squared error function. The degree of polynomials and the length of interpolation filter can be selected arbitrarily. Numerical examples verified the proposed design method not only can reduce the hardware cost effectively but also guarantee an excellent performance.
Design of Nonrecursive Digital Filters Using the Ultraspherical Window Function
Directory of Open Access Journals (Sweden)
Andreas Antoniou
2005-07-01
Full Text Available An efficient method for the design of nonrecursive digital filters using the ultraspherical window function is proposed. Economies in computation are achieved in two ways. First, through an efficient formulation of the window coefficients, the amount of computation required is reduced to a small fraction of that required by standard methods. Second, the filter length and the independent window parameters that would be required to achieve prescribed specifications in lowpass, highpass, bandpass, and bandstop filters as well as in digital differentiators and Hilbert transformers are efficiently determined through empirical formulas. Experimental results demonstrate that in many cases the ultraspherical window yields a lower-order filter relative to designs obtained using windows like the Kaiser, Dolph-Chebyshev, and SaramÃƒÂ¤ki windows. Alternatively, for a fixed filter length, the ultraspherical window yields reduced passband ripple and increased stopband attenuation relative to those produced when using the alternative windows.
International Nuclear Information System (INIS)
Auterinen, I.; Kotiluoto, P.; Hippelaeinen, E.; Kortesniemi, M.; Seppaelae, T.; Seren, T.; Mannila, V.; Poeyry, P.; Kankaanranta, L.; Collan, J.; Kouri, M.; Joensuu, H.; Savolainen, S.
2004-01-01
Improvements have been made at the FiR 1 BNCT facility to ease the positioning of the patient with a tumor in the head and neck region into a lateral neutron beam. Shoulder recesses were constructed horizontally on both sides of the beam aperture. When shoulder recesses are not needed, they are filled with neutron attenuating filling blocks. MCNP simulations using an anthropomorphic human model BOMAB phantom showed that the main contribution to the increase in the effective dose to the patient's body due to the shoulder recesses was from the neutron dose of the arm. In a position when one arm is inside the shoulder recess, the maximal effective dose of the patient was estimated to be 0.7 Sv/h. Dose measurements using the twin ionization chamber technique showed that the neutron dose increased on the sides as predicted by the MCNP model but there was no noticeable change in the gamma doses. When making the recesses into the lithium containing neutron shield material tritium contamination was confined using an underpressurized glove box and machine tools with local exhaust. The shoulder recesses give space for more flexible patient positioning and can be considered as a significant improvement of the Finnish BNCT facility
Recent Techniques in Design and Implementation of Microwave Planar Filters
Directory of Open Access Journals (Sweden)
P. K. Singhal
2008-12-01
Full Text Available This paper details the techniques and initiatives made recently for improved response and simultaneous development of microwave planar filters. Although the objective of all the techniques is to design low cost filters with reduced dimensions, compact size with better frequency response, the methodological approaches are quite variant. The paper has gone through extensive analysis of all these techniques, their concept and design procedures.
Design of High Performance Microstrip Dual-Band Bandpass Filter
Directory of Open Access Journals (Sweden)
N. Khajavi
2015-04-01
Full Text Available This paper presents a new design of dual-band bandpass filters using coupled stepped-impedance resonators for wireless systems. This architecture uses multiple couple stubs to tune the passband frequencies and the filter characteristics are improved using defected ground structure (DGS technique. Measurement results show insertion losses of 0.93 dB and 1.13 dB for the central frequencies of 2.35 GHz and 3.61 GHz, respectively. This filter is designed, fabricated and measured and the results of the simulation and measurement are in good agreement.
Feasibility study to develop BNCT facility at the Indonesian research reactor
International Nuclear Information System (INIS)
Hastowo, H.
2001-01-01
A survey on the Indonesian research reactors and its supporting facilities has been done in order to check the possibility to install BNCT facility. Oncologists from several hospitals have been informing about the BNCT treatment for tumours and they give a positive response to support utilisation of the BNCT facility. Several aspects required to support the BNCT treatment have also been identified and related activities on that matter soon will be initiated. The interim result in our survey indicated that utilisation of the 30 MW Multipurpose reactor would not be possible from the technical point of view. Further study will be concentrated on the TRIGA reactor and an epithermal neutron beam facility at the thermal column of this reactor will be designed for further work. (author)
Design of SAW FIR filters for quadrature binary modulation systems.
Vigil, A J; Malocha, D C; Belkerdid, M A
1993-01-01
Approaches for designing surface acoustic wave (SAW) filters used in pulsed quadrature binary modulation (QBM) systems are presented. Several previously defined pulse shapes were implemented by a SAW filter and showed good QBM system performance with respect to modulation envelope nonuniformity (AM) and intersymbol interference (ISI). A new approach to QBM pulse shape definition using both frequency- and time-domain design criteria is described. This approach allows families of new pulse shapes having various levels of AM and spectral confinement to be designed. The approaches to the design equations are presented, and examples of specific pulse shapes and their implementation using SAW filters are given. Time- and frequency-domain results of iteratively designed pulse shapes for application to QBM systems are also presented, showing good performance.
INEL BNCT research program: Annual report, 1995
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R. [ed.
1996-04-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented.
INEL BNCT research program: Annual report, 1995
International Nuclear Information System (INIS)
Venhuizen, J.R.
1996-04-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented
Optimal Spatial Matrix Filter Design for Array Signal Preprocessing
Directory of Open Access Journals (Sweden)
Haiyong Zhang
2014-01-01
Full Text Available An efficient technique of designing spatial matrix filter for array signal preprocessing based on convex programming was proposed. Five methods were considered for designing the filter. In design method 1, we minimized the passband fidelity subject to the controlled overall stopband attenuation level. In design method 2, the objective function and the constraint in the design method 1 were reversed. In design method 3, the optimal matrix filter which has the general mean square error was considered. In design method 4, the left stopband and the right stopband were constrained with specific attenuation level each, and the minimized passband fidelity was received. In design method 5, the optimization objective function was the sum of the left stopband and the right stopband attenuation levels with the weighting factors 1 and γ, respectively, and the passband fidelity was the constraints. The optimal solution of the optimizations above was derived by the Lagrange multiplier theory. The relations between the optimal solutions were analyzed. The generalized singular value decomposition was introduced to simplify the optimal solution of design methods 1 and 2 and enhanced the efficiency of solving the Lagrange multipliers. By simulations, it could be found that the proposed method was effective for designing the spatial matrix filter.
105 GHz Notch Filter Design for Collective Thomson Scattering
DEFF Research Database (Denmark)
Furtula, Vedran; Michelsen, Poul; Leipold, Frank
2011-01-01
A millimeter-wave notch filter with 105-GHz center frequency, >20-GHz passband coverage, and 1-GHz rejection bandwidth has been constructed. The design is based on a fundamental rectangular waveguide with cylindrical cavities coupled by narrow iris gaps, i.e., small elongated holes of negligible...... thickness. We use numerical simulations to study the sensitivity of the notch filter performance to changes in geometry and in material conductivity within a bandwidth of ±10 GHz. The constructed filter is tested successfully using a vector network analyzer monitoring a total bandwidth of 20 GHz....... The typical insertion loss in the passband is...
Coefficients Calculation in Pascal Approximation for Passive Filter Design
Directory of Open Access Journals (Sweden)
George B. Kasapoglu
2018-02-01
Full Text Available The recently modified Pascal function is further exploited in this paper in the design of passive analog filters. The Pascal approximation has non-equiripple magnitude, in contrast of the most well-known approximations, such as the Chebyshev approximation. A novelty of this work is the introduction of a precise method that calculates the coefficients of the Pascal function. Two examples are presented for the passive design to illustrate the advantages and the disadvantages of the Pascal approximation. Moreover, the values of the passive elements can be taken from tables, which are created to define the normalized values of these elements for the Pascal approximation, as Zverev had done for the Chebyshev, Elliptic, and other approximations. Although Pascal approximation can be implemented to both passive and active filter designs, a passive filter design is addressed in this paper, and the benefits and shortcomings of Pascal approximation are presented and discussed.
Novel design method for generalized lattice filters
DEFF Research Database (Denmark)
Agger, Søren; Povlsen, Jørn Hedegaard; Leick, Lasse
2003-01-01
A new design method for wide-band gain equalizers using cascaded MZI's is proposed. The method achieves a given accuracy with fewer stages than previously described methods. Furthermore, the method is capable of minimizing PDL.......A new design method for wide-band gain equalizers using cascaded MZI's is proposed. The method achieves a given accuracy with fewer stages than previously described methods. Furthermore, the method is capable of minimizing PDL....
FULL SCALE REGENERABLE HEPA FILTER DESIGN USING SINTERED METAL FILTER ELEMENTS
International Nuclear Information System (INIS)
Gil Ramos; Kenneth Rubow; Ronald Sekellick
2002-01-01
A Department of Energy funded contract involved the development of porous metal as a HEPA filter, and the subsequent design of a full-scale regenerable HEPA filtration system (RHFS). This RHFS could replace the glass fiber HEPA filters currently being used on the high level waste (HLW) tank ventilation system with a system that would be moisture tolerant, durable, and cleanable in place. The origins of the contract are a 1996 investigation at the Savannah River Technology Center (SRTC) regarding the use of porous metal as a HEPA filter material. This contract was divided into Phases I, IIA and IIB. Phase I of the contract evaluated simple filter cylinders in a simulated High Level Waste (HLW) environment and the ability to clean and regenerate the filter media after fouling. Upon the successful completion of Phase I, Phase IIA was conducted, which included lab scale prototype testing and design of a full-scale system. The work completed under Phase IIA included development of a full-scale system design, development of a filter media meeting the HEPA filtration efficiency that would also be regenerable using prescribed cleaning procedures, and the testing of a single element system prototype at Savannah River. All contract objectives were met. The filter media selected was a nickel material already under development at Mott, which met the HEPA filtration efficiency standard. The Mott nickel media met and exceeded the HEPA requirement, providing 99.99% removal against a requirement of 99.97%. Double open-ended elements of this media were provided to the Savannah River Test Center for HLW simulation testing in the single element prototype filter. These elements performed well and further demonstrated the practicality of a metallic media regenerable HEPA filter system. An evaluation of the manufacturing method on many elements demonstrated the reproducibility to meet the HEPA filtration requirement. The full-scale design of the Mott RHFS incorporated several important
Analysis of accelerator based neutron spectra for BNCT using proton recoil spectroscopy
International Nuclear Information System (INIS)
Wielopolski, L.; Ludewig, H.; Powell, J.R.; Raparia, D.; Alessi, J.G.; Lowenstein, D.I.
1998-01-01
Boron Neutron Capture Therapy (BNCT) is a promising binary treatment modality for high-grade primary brain tumors (glioblastoma multiforme, GM) and other cancers. BNCT employs a boron-10 containing compound that preferentially accumulates in the cancer cells in the brain. Upon neutron capture by 10 B energetic alpha particles and triton released at the absorption site kill the cancer cell. In order to gain penetration depth in the brain Fairchild proposed, for this purpose, the use of energetic epithermal neutrons at about 10 keV. Phase I/II clinical trials of BNCT for GM are underway at the Brookhaven Medical Research Reactor (BMRR) and at the MIT Reactor, using these nuclear reactors as the source for epithermal neutrons. In light of the limitations of new reactor installations, e.g. cost, safety and licensing, and limited capability for modulating the reactor based neutron beam energy spectra alternative neutron sources are being contemplated for wider implementation of this modality in a hospital environment. For example, accelerator based neutron sources offer the possibility of tailoring the neutron beams, in terms of improved depth-dose distributions, to the individual and offer, with relative ease, the capability of modifying the neutron beam energy and port size. In previous work new concepts for compact accelerator/target configuration were published. In this work, using the Van de Graaff accelerator the authors have explored different materials for filtering and reflecting neutron beams produced by irradiating a thick Li target with 1.8 to 2.5 MeV proton beams. However, since the yield and the maximum neutron energy emerging from the Li-7(p,n)Be-7 reaction increase with increase in the proton beam energy, there is a need for optimization of the proton energy versus filter and shielding requirements to obtain the desired epithermal neutron beam. The MCNP-4A computer code was used for the initial design studies that were verified with benchmark experiments
Design of Optimal Quincunx Filter Banks for Image Coding
Directory of Open Access Journals (Sweden)
Chen Yi
2007-01-01
Full Text Available Two new optimization-based methods are proposed for the design of high-performance quincunx filter banks for the application of image coding. These new techniques are used to build linear-phase finite-length-impulse-response (FIR perfect-reconstruction (PR systems with high coding gain, good frequency selectivity, and certain prescribed vanishing-moment properties. A parametrization of quincunx filter banks based on the lifting framework is employed to structurally impose the PR and linear-phase conditions. Then, the coding gain is maximized subject to a set of constraints on vanishing moments and frequency selectivity. Examples of filter banks designed using the newly proposed methods are presented and shown to be highly effective for image coding. In particular, our new optimal designs are shown to outperform three previously proposed quincunx filter banks in 72% to 95% of our experimental test cases. Moreover, in some limited cases, our optimal designs are even able to outperform the well-known (separable 9/7 filter bank (from the JPEG-2000 standard.
Digital IIR Filter Design Using Differential Evolution Algorithm
Directory of Open Access Journals (Sweden)
Nurhan Karaboga
2005-05-01
Full Text Available Any digital signal processing algorithm or processor can be reasonably described as a digital filter. The main advantage of an infinite impulse response (IIR filter is that it can provide a much better performance than the finite impulse response (FIR filter having the same number of coefficients. However, they might have a multimodal error surface. Differential evolution (DE algorithm is a new heuristic approach mainly having three advantages; finding the true global minimum of a multimodal search space regardless of the initial parameter values, fast convergence, and using a few control parameters. In this work, DE algorithm has been applied to the design of digital IIR filters and its performance has been compared to that of a genetic algorithm.
Design and control of hybrid active power filters
Lam, Chi-Seng
2014-01-01
Design and Control of Hybrid Active Power Filters presents an overview of the current quality problems and their compensators. To get a balance between the system cost and performance, hybrid active power filters (HAPFs) are valuable. The book presents the coverage of resonance phenomena prevention capability, filtering performance and system robustness analysis of HAPF; nonlinear inverter current slope characteristics and their linear operation region requirement analysis of the hysteresis PWM for the HAPF; minimum inverter capacity design procedure of HAPF, adaptive dc-link voltage controller for the HAPF and the real design example of a 220V 10kVA HAPF, in which the system performance analysis method, minimum dc voltage deduction concept and adaptive dc voltage idea can be further extended into the other active compensators, such as APF, static synchronous compensator STATCOM, etc. This book will benefit researchers, graduate students, and electrical power engineers in the field of power-quality compensati...
Effect of filter designs on hydraulic properties and well efficiency.
Kim, Byung-Woo
2014-09-01
To analyze the effect of filter pack arrangement on the hydraulic properties and the well efficiency of a well design, a step drawdown was conducted in a sand-filled tank model. Prior to the test, a single filter pack (SFP), granule only, and two dual filter packs (DFPs), type A (granule-pebble) and type B (pebble-granule), were designed to surround the well screen. The hydraulic properties and well efficiencies related to the filter packs were evaluated using the Hazen's, Eden-Hazel's, Jacob's, and Labadie-Helweg's methods. The results showed that the hydraulic properties and well efficiency of the DFPs were higher than those of a SFP, and the clogging effect and wellhead loss related to the aquifer material were the lowest owing to the grain size and the arrangement of the filter pack. The hydraulic conductivity of the DFPs types A and B was about 1.41 and 6.43 times that of a SFP, respectively. In addition, the well efficiency of the DFPs types A and B was about 1.38 and 1.60 times that of the SFP, respectively. In this study, hydraulic property and well efficiency changes were observed according to the variety of the filter pack used. The results differed from the predictions of previous studies on the grain-size ratio. Proper pack-aquifer ratios and filter pack arrangements are primary factors in the construction of efficient water wells, as is the grain ratio, intrinsic permeability (k), and hydraulic conductivity (K) between the grains of the filter packs and the grains of the aquifer. © 2014, National Ground Water Association.
Intelligent Optimize Design of LCL Filter for Three-Phase Voltage-Source PWM Rectifier
DEFF Research Database (Denmark)
Sun, Wei; Chen, Zhe; Wu, Xiaojie
2009-01-01
Compared to traditional L filter, a LCL filter is more effective on reducing harmonic distortion at switch frequency. So it is important to choose the LCL filter parameters to achieve good filtering effect. This paper introduces some traditional design methods. Design of a LCL filter by genetic a...
Designing Asynchronous Circuits for Low Power: An IFIR Filter
DEFF Research Database (Denmark)
Nielsen, Lars Skovby; Sparsø, Jens
1999-01-01
This paper addresses the design of asynchronous circuits for low power through an example: a filter bank for a digital hearing aid. The asynchronous design re-implements an existing synchronous circuit which is used in a commercial product. For comparison, both designs have been fabricated...... by numerically small samples). Apart from the improved RAM design, these measures are only viable in an asynchronous design. The principles and techniques explained in this paper are of a general nature, and they apply to the design of asynchronous low-power digital signal-processing circuits in a broader...
Broadband notch filter design for millimeter-wave plasma diagnostics.
Furtula, V; Michelsen, P K; Leipold, F; Salewski, M; Korsholm, S B; Meo, F; Nielsen, S K; Stejner, M; Moseev, D; Johansen, T
2010-10-01
Notch filters are integrated in plasma diagnostic systems to protect millimeter-wave receivers from intensive stray radiation. Here we present a design of a notch filter with a center frequency of 140 GHz, a rejection bandwidth of ∼900 MHz, and a typical insertion loss below 2 dB in the passband of ±9 GHz. The design is based on a fundamental rectangular waveguide with eight cylindrical cavities coupled by T-junction apertures formed as thin slits. Parameters that affect the notch performance such as physical lengths and conductor materials are discussed. The excited resonance mode in the cylindrical cavities is the fundamental TE(11). The performance of the constructed filter is measured using a vector network analyzer monitoring a total bandwidth of 30 GHz. We compare the measurements with numerical simulations.
Design strategy for the combined system of shunt passive and series active filters
Fujita, Hideki; Akagi, Hirofumi
1991-01-01
A design strategy for the combined power filter for a three-phase twelve-pulse thyristor rectifier is proposed. The shunt passive filter, which can minimize the output voltage of the series active filter, is designed and tested in a prototype model. A specially designed shunt passive filter makes it possible to reduce the required rating of the series active filter to 60% compared with a conventional shunt passive filter
Nuclear engineering aspects of glioma BNCT research in Italy
International Nuclear Information System (INIS)
Curzio, G.; Mazzini, M.
1998-01-01
A research project on Boron Neutron Capture Therapy (BNCZ) of gliomas has been set up in Italy, with the participation of Departments of Oncology and Mechanical and Nuclear Construction (DCMN) of the University of Pisa, as well as the Neuroscience and Physics Departments of the Universities of Roma. The specific objective of DCMN Research Unit is the study of the physical-engineering aspects related to BNCT. The paper outlines the research lines in progress at DCMN: Monte Carlo calculations of neutron dose distribution for BNCT treatment planning; measurements of neutron fluxes, spectra and doses by neutron detectors specifically set up; design of modifications to the nuclear reactors of ENEA Casaccia Center. In particular, the paper emphasizes the most original contributions on dosimetric aspects, both from informatic and experimental points of view.(author)
Gravitation search algorithm: Application to the optimal IIR filter design
Directory of Open Access Journals (Sweden)
Suman Kumar Saha
2014-01-01
Full Text Available This paper presents a global heuristic search optimization technique known as Gravitation Search Algorithm (GSA for the design of 8th order Infinite Impulse Response (IIR, low pass (LP, high pass (HP, band pass (BP and band stop (BS filters considering various non-linear characteristics of the filter design problems. This paper also adopts a novel fitness function in order to improve the stop band attenuation to a great extent. In GSA, law of gravity and mass interactions among different particles are adopted for handling the non-linear IIR filter design optimization problem. In this optimization technique, searcher agents are the collection of masses and interactions among them are governed by the Newtonian gravity and the laws of motion. The performances of the GSA based IIR filter designs have proven to be superior as compared to those obtained by real coded genetic algorithm (RGA and standard Particle Swarm Optimization (PSO. Extensive simulation results affirm that the proposed approach using GSA outperforms over its counterparts not only in terms of quality output, i.e., sharpness at cut-off, smaller pass band ripple, higher stop band attenuation, but also the fastest convergence speed with assured stability.
Design and analysis of electromagnetic interference filters and shields
McDowell, Andrew Joel
Electromagnetic interference (EMI) is a problem of rising prevalence as electronic devices become increasingly ubiquitous. EMI filters are low pass filters intended to prevent the conducted electric currents and radiated electromagnetic fields of a device from interfering with the proper operation of other devices. Shielding is a method, often complementary to filtering, that typically involves enclosing a device in a conducting box in order to prevent radiated EMI. This dissertation includes three chapters related to the use of filtering and shielding for preventing electromagnetic interference. The first chapter deals with improving the high frequency EMI filtering performance of surface mount capacitors on printed circuit boards (PCBs). At high frequencies, the impedance of a capacitor is dominated by a parasitic inductance, thus leading to poor high frequency filtering performance. Other researchers have introduced the concept of parasitic inductance cancellation and have applied this concept to improving the filtering performance of volumetrically large capacitors at frequencies up to 100 MHz. The work in this chapter applies the concept of parasitic inductance cancellation to much smaller surface mount capacitors at frequencies up to several gigahertz. The second chapter introduces a much more compact design for applying parasitic inductance cancellation to surface mount capacitors that uses inductive coupling between via pairs as well as coplanar traces. This new design is suited for PCBs having three or more layers including solid ground and/or power plane(s). This design is demonstrated to be considerably more effective in filtering high frequency noise due to crosstalk than a comparable conventional shunt capacitor filter configuration. Finally, chapter 3 presents a detailed analysis of the methods that are used to decompose the measure of plane wave shielding effectiveness into measures of absorption and reflection. Textbooks on electromagnetic
Analysis and Design of Offset QPSK Using Redundant Filter Banks
International Nuclear Information System (INIS)
Fernandez-Vazquez, Alfonso; Jovanovic-Dolecek, Gordana
2013-01-01
This paper considers the analysis and design of OQPSK digital modulation. We first establish the discrete time formulation, which allows us to find the equivalent redundant filter banks. It is well known that redundant filter banks are related with redundant transformation of the Frame theory. According to the Frame theory, the redundant transformations and corresponding representations are not unique. In this way, we show that the solution to the pulse shaping problem is not unique. Then we use this property to minimize the effect of the channel noise in the reconstructed symbol stream. We evaluate the performance of the digital communication using numerical examples.
Three different criteria for the design of two-dimensional zero phase FIR digital filters
DEFF Research Database (Denmark)
Gislason, E.; Johansen, M.; Conradsen, Knut
1993-01-01
An error criterion for the design of FIR filters is proposed. Filters with relatively many free filter coefficients are designed using the Chebyshev, the weighted-least-squares (WLS), and a new partitioned minimax error criterion, and the performance of the filters is compared. A general and fast...... technique for the WLS design is also presented.>...
Measurement and simulation of the TRR BNCT beam parameters
Energy Technology Data Exchange (ETDEWEB)
Bavarnegin, Elham [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Sadremomtaz, Alireza [Department of Physics, University of Guilan, Rasht (Iran, Islamic Republic of); Khalafi, Hossein [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Kasesaz, Yaser, E-mail: ykasesaz@aeoi.org.ir [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of); Golshanian, Mohadeseh; Ghods, Hossein; Ezzati, Arsalan; Keyvani, Mehdi; Haddadi, Mohammad [Nuclear Science and Technology Research Institute (NSTRI), Tehran (Iran, Islamic Republic of)
2016-09-11
Recently, the configuration of the Tehran Research Reactor (TRR) thermal column has been modified and a proper thermal neutron beam for preclinical Boron Neutron Capture Therapy (BNCT) has been obtained. In this study, simulations and experimental measurements have been carried out to identify the BNCT beam parameters including the beam uniformity, the distribution of the thermal neutron dose, boron dose, gamma dose in a phantom and also the Therapeutic Gain (TG). To do this, the entire TRR structure including the reactor core, pool, the thermal column and beam tubes have been modeled using MCNPX Monte Carlo code. To measure in-phantom dose distribution a special head phantom has been constructed and foil activation techniques and TLD700 dosimeter have been used. The results show that there is enough uniformity in TRR thermal BNCT beam. TG parameter has the maximum value of 5.7 at the depth of 1 cm from the surface of the phantom, confirming that TRR thermal neutron beam has potential for being used in treatment of superficial brain tumors. For the purpose of a clinical trial, more modifications need to be done at the reactor, as, for example design, and construction of a treatment room at the beam exit which is our plan for future. To date, this beam is usable for biological studies and animal trials. There is a relatively good agreement between simulation and measurement especially within a diameter of 10 cm which is the dimension of usual BNCT beam ports. This relatively good agreement enables a more precise prediction of the irradiation conditions needed for future experiments.
Clinical results of BNCT for malignant meningiomas
International Nuclear Information System (INIS)
Miyatake, Shin-ichi; Tamura, Yoji; Kawabata, Shinji
2006-01-01
Malignant meningiomas is difficult pathology to be controlled as well as GBM. Since June of 2005, we applied BNCT for 7 cases of malignancy related meningiomas with 13 times neutron irradiation. Five were anaplastic, one was atypical meningiomas and one was sarcoma transformed from meningioma with cervical lymph node metastasis. All cases were introduced after repetitive surgeries and XRT or SRS. Follow-up images were available for 6 cases with observation duration between 2 to 9 months. We applied F-BPA-PET before BNCT in 6 out of 7 cases. One case was received methionine-PET. Five out of 6 cases who received BPA-PET study showed good BPA uptake more than 3 of T/N ratio. One atypical meningiomas cases showed 2.0 of T/N ratio. Original tumor sizes were between 9.2 to 92.7 ml. Two out of 5 anaplastic meningiomas showed CR and all six cases showed radiographic improvements. Clinical symptoms before BNCT such as hemiparesis and facial pain were improved after BNCT, except one case. An huge atypical meningiomas which arisen from tentorium and extended bilateral occipital lobes and brain stem, visual problems were worsened after repetitive BNCT with increase of peritumoral edema. Malignant meningiomas are seemed to be good candidate for BNCT. (author)
Clock Jitter Effect on Switched-Capacitor Filter Design
El Oualkadi, Ahmed; Paillot, Jean-Marie; Flandre, Denis
2006-01-01
International audience; This paper proposes the study of clock jitter effect on high-Q switched-capacitor filter behavior. A command circuit made up by a ring voltage controlled oscillator (VCO) with XOR gates is used to generate the command signals. According to the correlation of these signals the jitter effect on the signal constellation has been studied. A good agreement between measured and simulation results has been achieved which validate our design methodology.
Characterisation of an accelerator-based neutron source for BNCT versus beam energy
Agosteo, S; D'Errico, F; Nath, R; Tinti, R
2002-01-01
Neutron capture in sup 1 sup 0 B produces energetic alpha particles that have a high linear energy transfer in tissue. This results in higher cell killing and a higher relative biological effectiveness compared to photons. Using suitably designed boron compounds which preferentially localize in cancerous cells instead of healthy tissues, boron neutron capture therapy (BNCT) has the potential of providing a higher tumor cure rate within minimal toxicity to normal tissues. This clinical approach requires a thermal neutron source, generally a nuclear reactor, with a fluence rate sufficient to deliver tumorcidal doses within a reasonable treatment time (minutes). Thermal neutrons do not penetrate deeply in tissue, therefore BNCT is limited to lesions which are either superficial or otherwise accessible. In this work, we investigate the feasibility of an accelerator-based thermal neutron source for the BNCT of skin melanomas. The source was designed via MCNP Monte Carlo simulations of the thermalization of a fast ...
Development and analysis of vent-filtered containment conceptual designs
International Nuclear Information System (INIS)
Benjamin, A.S.; Walling, H.C.
1980-01-01
Conceptual filtered-vented containment systems have been postulated for a reference large, dry, pressurized water reactor containment, and the systems have been analyzed to determine design parameters, actuation/operation requirements, and overall feasibility. The primary design challenge has been found to emanate from pressure spikes caused by core debris bed interactions with water and by hydrogen deflagrations. Circumvention of the pressure spikes may require a more complicated actuation logic than has previously been considered. Otherwise, major reductions in consequences for certain severe accidents appear to be possible with relatively simple systems. A probabilistic assessment of competing risks remains to be performed
Lin, Dan; Hossack, John A.
2012-01-01
A general filtering method, called the singular value filter (SVF), is presented as a framework for principal component analysis (PCA) based filter design in medical ultrasound imaging. The SVF approach operates by projecting the original data onto a new set of bases determined from PCA using singular value decomposition (SVD). The shape of the SVF weighting function, which relates the singular value spectrum of the input data to the filtering coefficients assigned to each basis function, is designed in accordance with a signal model and statistical assumptions regarding the underlying source signals. In this paper, we applied SVF for the specific application of clutter artifact rejection in diagnostic ultrasound imaging. SVF was compared to a conventional PCA-based filtering technique, which we refer to as the blind source separation (BSS) method, as well as a simple frequency-based finite impulse response (FIR) filter used as a baseline for comparison. The performance of each filter was quantified in simulated lesion images as well as experimental cardiac ultrasound data. SVF was demonstrated in both simulation and experimental results, over a wide range of imaging conditions, to outperform the BSS and FIR filtering methods in terms of contrast-to-noise ratio (CNR) and motion tracking performance. In experimental mouse heart data, SVF provided excellent artifact suppression with an average CNR improvement of 1.8 dB (P filtering was achieved using complex pulse-echo received data and non-binary filter coefficients. PMID:21693416
Design and optimization of multipole lens and Wien filter systems
Energy Technology Data Exchange (ETDEWEB)
Liu Haoning, E-mail: haoning@mebs.co.uk [Munro' s Electron Beam Software Ltd., 14 Cornwall Gardens, London SW7 4AN (United Kingdom); Wang Liping; Rouse, John; Munro, Eric [Munro' s Electron Beam Software Ltd., 14 Cornwall Gardens, London SW7 4AN (United Kingdom)
2011-07-21
The differential algebra (DA) method has been employed to compute the optical properties and aberrations up to the fifth order of multipole systems containing electrostatic and magnetic round, quadrupole, hexapole and octopole lenses, and Wien filters. A new software package has been developed, which computes the geometrical and chromatic aberrations up to the fifth order by using a single DA ray trace. It also has an optimization module where a weighted set of aberrations can be minimized by the automatic adjustment of a set of user-defined system variables. In this paper, we present our new method for designing and optimizing multipole systems including Wien filters, and illustrate its application with three relevant examples.
Design and optimization of multipole lens and Wien filter systems
Liu, Haoning; Wang, Liping; Rouse, John; Munro, Eric
2011-07-01
The differential algebra (DA) method has been employed to compute the optical properties and aberrations up to the fifth order of multipole systems containing electrostatic and magnetic round, quadrupole, hexapole and octopole lenses, and Wien filters. A new software package has been developed, which computes the geometrical and chromatic aberrations up to the fifth order by using a single DA ray trace. It also has an optimization module where a weighted set of aberrations can be minimized by the automatic adjustment of a set of user-defined system variables. In this paper, we present our new method for designing and optimizing multipole systems including Wien filters, and illustrate its application with three relevant examples.
Fazel Sharifi; Saba Amanollahi; Mohammad Amin Taherkhani; Omid Hashemipour
2012-01-01
FIR filters are used in many performance/power critical applications such as mobile communication devices, analogue to digital converters and digital signal processing applications. Design of appropriate FIR filters usually causes the order of filter to be increased. Synthesis and tape-out of high-order FIR filters with reasonable delay, area and power has become an important challenge for hardware designers. In many cases the complexity of high-order filters causes the constraints of the tot...
Design Of EMI Filter For Flash Lamp Power Supply
Directory of Open Access Journals (Sweden)
Amrita Bhatt
2015-08-01
Full Text Available Abstract Conducted and radiated electromagnetic interference in embedded and VLSI systems have become important in recent years with increase in clock frequency and reduction in physical dimensions of interconnects. It is important to understand the noise components in terms of current paths and the mitigation techniques. Although the common mode and differential mode components of conducted noise are analyzed in the context of a power electronics system the analytical and theoretical techniques hold good for other domains as well such as embedded systems and VLSI. This paper deals with modelling design and development of an EMI filter for conducted mode noise in flash lamp power supply. Also a design procedure of EMI filters sustaining to the military standard 461E is presented and it is based on practical measurement of conducted emissions. Design procedure in this paper considers common mode and differential mode separately. The paper also consists of considerations for magnetic core material integrated common mode CM common mode choke size optimization and differential mode DM choke etc. Design examples are given and are experimentally verified.
The Methods of Design and Implementation of Stack Filters for Image Processing
Directory of Open Access Journals (Sweden)
S. Marchevsky
1995-04-01
Full Text Available This paper deals with a large class of nonlinear digital filters, the stack filters, which contain all combinations and compositions of rank order operators within a finite window. Attention is given to design and effective hardware implementation of an optimal stack filter for image processing. Presented simulation results confirm robustness of stack filters in the image restoration corrupted by impulsive noise.
Vora, A. P.; Rami, J. B.; Hait, A. K.; Dewan, C. P.; Subrahmanyam, D.; Kirankumar, A. S.
2017-11-01
Next generation Indian Meteorological Satellite will carry Sounder instrument having subsystem of filter wheel measuring Ø260mm and carrying 18 filters arranged in three concentric rings. These filters made from Germanium, are used to separate spectral channels in IR band. Filter wheel is required to be cooled to 214K and rotated at 600 rpm. This Paper discusses the challenges faced in mechanical design of the filter wheel, mainly filter mount design to protect brittle germanium filters from failure under stresses due to very low temperature, compactness of the wheel and casings for improved thermal efficiency, survival under vibration loads and material selection to keep it lighter in weight. Properties of Titanium, Kovar, Invar and Aluminium materials are considered for design. The mount has been designed to accommodate both thermal and dynamic loadings without introducing significant aberrations into the optics or incurring permanent alignment shifts. Detailed finite element analysis of mounts was carried out for stress verification. Results of the qualification tests are discussed for given temperature range of 100K and vibration loads of 12g in Sine and 11.8grms in Random at mount level. Results of the filter wheel qualification as mounted in Electro Optics Module (EOM) are also presented.
AESOP- INTERACTIVE DESIGN OF LINEAR QUADRATIC REGULATORS AND KALMAN FILTERS
Lehtinen, B.
1994-01-01
AESOP was developed to solve a number of problems associated with the design of controls and state estimators for linear time-invariant systems. The systems considered are modeled in state-variable form by a set of linear differential and algebraic equations with constant coefficients. Two key problems solved by AESOP are the linear quadratic regulator (LQR) design problem and the steady-state Kalman filter design problem. AESOP is designed to be used in an interactive manner. The user can solve design problems and analyze the solutions in a single interactive session. Both numerical and graphical information are available to the user during the session. The AESOP program is structured around a list of predefined functions. Each function performs a single computation associated with control, estimation, or system response determination. AESOP contains over sixty functions and permits the easy inclusion of user defined functions. The user accesses these functions either by inputting a list of desired functions in the order they are to be performed, or by specifying a single function to be performed. The latter case is used when the choice of function and function order depends on the results of previous functions. The available AESOP functions are divided into several general areas including: 1) program control, 2) matrix input and revision, 3) matrix formation, 4) open-loop system analysis, 5) frequency response, 6) transient response, 7) transient function zeros, 8) LQR and Kalman filter design, 9) eigenvalues and eigenvectors, 10) covariances, and 11) user-defined functions. The most important functions are those that design linear quadratic regulators and Kalman filters. The user interacts with AESOP when using these functions by inputting design weighting parameters and by viewing displays of designed system response. Support functions obtain system transient and frequency responses, transfer functions, and covariance matrices. AESOP can also provide the user
International Nuclear Information System (INIS)
Masoudi, S. Farhad; Rasouli, Fatemeh S.
2015-01-01
Recent studies in BNCT have focused on investigating appropriate neutron sources as alternatives for nuclear reactors. As the most prominent facilities, the electron linac based photoneutron sources benefit from two consecutive reactions, (e, γ) and (γ, n). The photoneutron sources designed so far are composed of bipartite targets which involve practical problems and are far from the objective of achieving an optimized neutron source. This simulation study deals with designing a compact, optimized, and geometrically simple target for a photoneutron source based on an electron linac. Based on a set of MCNPX simulations, tungsten is found to have the potential of utilizing as both photon converter and photoneutron target. Besides, it is shown that an optimized dimension for such a target slows-down the produced neutrons toward the desired energy range while keeping them economy, which makes achieving the recommended criteria for BNCT of deep-tumors more available. This multi-purpose target does not involve complicated designing, and can be considered as a significant step toward finding application of photoneutron sources for in-hospital treatments. In order to shape the neutron beam emitted from such a target, the beam is planned to pass through an optimized arrangement of materials composed of moderators, filters, reflector, and collimator. By assessment with the recommended in-air parameters, it is shown that the designed beam provides high intensity of desired neutrons, as well as low background contamination. The last section of this study is devoted to investigate the performance of the resultant beam in deep tissue. A typical simulated liver tumor, located within a phantom of human body, was subjected to the irradiation of the designed spectrum. The dosimetric results, including evaluated depth-dose curves and carried out in-phantom parameters show that the proposed configuration establishes acceptable agreement between the appropriate neutron intensity, and
BNCT Technology Development on HANARO Reactor
Energy Technology Data Exchange (ETDEWEB)
Chun, Ki Jung; Park, Kyung Bae; Whang, Seung Ryul; Kim, Myong Seop
2007-06-15
So as to establish the biological effects of BNCT in the HANARO Reactor, biological damages in cells and animals with treatment of boron/neutron were investigated. And 124I-BPA animal PET image, analysis technology of the boron contents in the mouse tissues by ICP-AES was established. A Standard clinical protocol, a toxicity evaluation report and an efficacy investigation report of BNCT has been developed. Based on these data, the primary permission of clinical application was acquired through IRB of our hospital. Three cases of pre-clinical experiment for boron distribution and two cases of medium-sized animal simulation experiment using cat with verifying for 2 months after BNCT was performed and so the clinical demonstration with a patient was prepared. Also neutron flux, fast neutron flux and gamma ray dose of BNCT facility were calculated and these data will be utilized good informations for clinical trials and further BNCT research. For the new synthesis of a boron compound, o-carboranyl ethylamine, o-carboranylenepiperidine, o-carboranyl-THIQ and o-carboranyl-s-triazine derivatives were synthesized. Among them, boron uptake in the cancer cell of the triazine derivative was about 25 times than that of BPA and so these three synthesized methods of new boron compounds were patented.
BNCT Technology Development on HANARO Reactor
International Nuclear Information System (INIS)
Chun, Ki Jung; Park, Kyung Bae; Whang, Seung Ryul; Kim, Myong Seop
2007-06-01
So as to establish the biological effects of BNCT in the HANARO Reactor, biological damages in cells and animals with treatment of boron/neutron were investigated. And 124I-BPA animal PET image, analysis technology of the boron contents in the mouse tissues by ICP-AES was established. A Standard clinical protocol, a toxicity evaluation report and an efficacy investigation report of BNCT has been developed. Based on these data, the primary permission of clinical application was acquired through IRB of our hospital. Three cases of pre-clinical experiment for boron distribution and two cases of medium-sized animal simulation experiment using cat with verifying for 2 months after BNCT was performed and so the clinical demonstration with a patient was prepared. Also neutron flux, fast neutron flux and gamma ray dose of BNCT facility were calculated and these data will be utilized good informations for clinical trials and further BNCT research. For the new synthesis of a boron compound, o-carboranyl ethylamine, o-carboranylenepiperidine, o-carboranyl-THIQ and o-carboranyl-s-triazine derivatives were synthesized. Among them, boron uptake in the cancer cell of the triazine derivative was about 25 times than that of BPA and so these three synthesized methods of new boron compounds were patented
Experimental study on the performance of an epithermal neutron flux monitor for BNCT.
Guan, Xingcai; Manabe, Masanobu; Tamaki, Shingo; Liu, Shuangtong; Sato, Fuminobu; Murata, Isao; Wang, Tieshan
2016-07-01
The performance of an epithermal neutron (0.5eVflux monitor designed for boron neutron capture therapy (BNCT) was experimentally studied by using a prototype monitor in an appropriate neutron field at the intense deuterium-tritium neutron source facility OKTAVIAN of Osaka University, Japan. It was convinced from the experimental results that the developed monitor worked well and the epithermal neutron fluxes in BNCT neutron sources can be measured within 5% by the monitor. Copyright © 2016 Elsevier Ltd. All rights reserved.
Cross talk experiment with two-element CdTe detector and collimator for BNCT-SPECT
Energy Technology Data Exchange (ETDEWEB)
Manabe, Masanobu; Ohya, Ryosuke; Saraue, Nobuhide; Sato, Fuminobu; Murata, Isao [Osaka University, Osaka (Japan)
2016-12-15
Boron Neutron Capture Therapy (BNCT) is a new radiation therapy. In BNCT, there exists some very critical problems that should be solved. One of the severest problems is that the treatment effect cannot be known during BNCT in real time. We are now developing a SPECT (single photon emission computed tomography) system (BNCT-SPECT), with a cadmium telluride (CdTe) semiconductor detector. BNCT-SPECT can obtain the BNCT treatment effect by measuring 478 keV gamma-rays emitted from the excited state of 7Li nucleus created by 10B(n,α) 7Li reaction. In the previous studies, we investigated the feasibility of the BNCT-SPECT system. As a result, the S/N ratio did not meet the criterion of S/N >1 because deterioration of the S/N ratio occurred caused by the influence of Compton scattering especially due to capture gamma-rays of hydrogen. We thus produced an arrayed detector with two CdTe crystals to test cross talk phenomenon and to examine an anti-coincidence detection possibility. For more precise analysis for the anti-coincidence detection, we designed and made a collimator having a similar performance to the real BNCT-SPECT. We carried out experiments with the collimator to examine the effect of cross talk of scattering gamma-rays between CdTe elements more practically. As a result of measurement the coincidence events were successfully extracted. We are now planning to carry out evaluation of coincidence rate from the measurement and comparison of it with the numerical calculations.
Design of broadband filters and antennas for SAMBA
Goldin, Alexey; Bock, James J.; Hunt, Cynthia L.; Lange, Andrew E.; LeDuc, Henry G.; Vayonakis, Anastasios; Zmuidzinas, Jonas
2003-02-01
We present a design for multipixel, multiband submillimeter instrument: SAMBA (Superconducting Antenna-coupled, Multi-frequency, Bolometric Array). SAMBA uses antenna coupled bolometers and microstrip filters. The concept allows for a much more compact, multiband imager compared to a comparable feedhorn-coupled bolometric system. SAMBA incorporates an array of slot antennas, superconducting transmission lines, a wide band multiplexer and superconducting transition edge bolometers. The transition-edge film measures the millimeter-wave power deposited in the resistor that terminates the transmission line.
Stochastic simulation and robust design optimization of integrated photonic filters
Directory of Open Access Journals (Sweden)
Weng Tsui-Wei
2016-07-01
Full Text Available Manufacturing variations are becoming an unavoidable issue in modern fabrication processes; therefore, it is crucial to be able to include stochastic uncertainties in the design phase. In this paper, integrated photonic coupled ring resonator filters are considered as an example of significant interest. The sparsity structure in photonic circuits is exploited to construct a sparse combined generalized polynomial chaos model, which is then used to analyze related statistics and perform robust design optimization. Simulation results show that the optimized circuits are more robust to fabrication process variations and achieve a reduction of 11%–35% in the mean square errors of the 3 dB bandwidth compared to unoptimized nominal designs.
Minimax passband group delay nonlinear FIR filter design without imposing desired phase response
Ho, Charlotte Yuk-Fan; Ling, Wing-Kuen; Dam, Hai Huyen; Yeo, Kok-Lay
2011-01-01
In this paper, a nonlinear phase finite impulse response (FIR) filter is designed without imposing a desired phase response. The maximum passband group delay of the filter is minimized subject to a positivity constraint on the passband group delay response of the filter as well as a specification on the maximum absolute difference between the desired magnitude square response and the designed magnitude square response over both the passband and the stopband. This filter design problem is a no...
Design and analysis of an optical FIR filter
Sharma, Anuj Kumar; Sharma, Sandeep; Kumar, Santosh
2016-04-01
In this paper, an optical finite impulse response (FIR) filter is proposed. An optical FIR filter can produce arbitrary spectrum output based on transfer function. The corresponding relationship between an optical filter and FIR filter is analyzed and analysis is presented in detail.
Spectrum shaping of accelerator-based neutron beams for BNCT
Montagnini, B; Esposito, J; Giusti, V; Mattioda, F; Varone, R
2002-01-01
We describe Monte Carlo simulations of three facilities for the production of epithermal neutrons for Boron Neutron Capture Therapy (BNCT) and examine general aspects and problems of designing the spectrum-shaping assemblies to be used with these neutron sources. The first facility is based on an accelerator-driven low-power subcritical reactor, operating as a neutron amplifier. The other two facilities have no amplifier and rely entirely on their primary sources, a D-T fusion reaction device and a conventional 2.5 MeV proton accelerator with a Li target, respectively.
Clutter filter design for ultrasound color flow imaging.
Bjaerum, Steinar; Torp, Hans; Kristoffersen, Kjell
2002-02-01
For ultrasound color flow images with high quality, it is important to suppress the clutter signals originating from stationary and slowly moving tissue sufficiently. Without sufficient clutter rejection, low velocity blood flow cannot be measured, and estimates of higher velocities will have a large bias. The small number of samples available (8 to 16) makes clutter filtering in color flow imaging a challenging problem. In this paper, we review and analyze three classes of filters: finite impulse response (FIR), infinite impulse response (IIR), and regression filters. The quality of the filters was assessed based on the frequency response, as well as on the bias and variance of a mean blood velocity estimator using an autocorrelation technique. For FIR filters, the frequency response was improved by allowing a non-linear phase response. By estimating the mean blood flow velocity from two vectors filtered in the forward and backward direction, respectively, the standard deviation was significantly lower with a minimum phase filter than with a linear phase filter. For IIR filters applied to short signals, the transient part of the output signal is important. We analyzed zero, step, and projection initialization, and found that projection initialization gave the best filters. For regression filters, polynomial basis functions provide effective clutter suppression. The best filters from each of the three classes gave comparable bias and variance of the mean blood velocity estimates. However, polynomial regression filters and projection-initialized IIR filters had a slightly better frequency response than could be obtained with FIR filters.
Yashika Saini; Mithilesh Kumar
2014-01-01
A compact ultra-wideband (UWB) bandpass filter (BPF) with wide passband using defected ground structure (DGS) is proposed. The proposed UWB filter is constructed by cascading a high pass filter (HPF) and a lowpass filter (LPF). HPF with short-circuited stubs is used to realize the lower stopband and a LPF is used to attenuate the upper stopband. In order to make the filter size compact, DGS technology is incorporated in the filter design, with this technique the size of filter becomes extreme...
Production of epithermal neutron beams for BNCT
Bisceglie, E; Colonna, N; Paticchio, V; Santorelli, P; Variale, V
2002-01-01
The use of boron neutron capture therapy (BNCT) for the treatment of deep-seated tumors requires neutron beams of suitable energy and intensity. Simulations indicate the optimal energy to reside in the epithermal region, in particular between 1 and 10 keV. Therapeutic neutron beams with high spectral purity in this energy range could be produced with accelerator-based neutron sources through a suitable neutron-producing reaction. Herein, we report on different solutions that have been investigated as possible sources of epithermal neutron beams for BNCT. The potential use of such sources for a hospital-based therapeutic facility is discussed.
Multi-objective Design Method for Hybrid Active Power Filter
Yu, Jingrong; Deng, Limin; Liu, Maoyun; Qiu, Zhifeng
2017-10-01
In this paper, a multi-objective optimal design for transformerless hybrid active power filter (HAPF) is proposed. The interactions between the active and passive circuits is analyzed, and by taking the interactions into consideration, a three-dimensional objective problem comprising of performance, efficiency and cost of HAPF system is formulated. To deal with the multiple constraints and the strong coupling characteristics of the optimization model, a novel constraint processing mechanism based on distance measurement and adaptive penalty function is presented. In order to improve the diversity of optimal solution and the local searching ability of the particle swarm optimization (PSO) algorithm, a chaotic mutation operator based on multistage neighborhood is proposed. The simulation results show that the optimums near the ordinate origin of the three-dimension space make better tradeoff among the performance, efficiency and cost of HAPF, and the experimental results of transformerless HAPF verify the effectiveness of the method for multi-objective optimization and design.
Design of the LC+trap filter for a current source rectifier
DEFF Research Database (Denmark)
Min, Huang; Wang, Xiongfei; Loh, Poh Chiang
2015-01-01
capacitor voltage and the line current THD for space vector modulation. The resonance of the input filter can be excited by the Pulse Width Modulation (PWM) and a simple passive damping can damp the resonances. The analysis and design of the input filter have been verified by simulations in MATLAB/Simulink.......This paper investigates an LC + trap filter for current source converters to improve the switching harmonic attenuation. The resonant frequency characteristics of the filter of current source rectifier are analyzed. A filter design procedure is proposed based on the input power factor, filter...
Almost minimax design of FIR filter using an IRLS algorithm without matrix inversion
Zhao, Ruijie; Lin, Zhiping; Toh, Kar-Ann; Sun, Lei; Lai, Xiaoping
2017-06-01
An iterative reweighted least squares (IRLS) algorithm is presented in this paper for the minimax design of FIR filters. In the algorithm, the resulted subproblems generated by the weighted least squares (WLS) are solved by using the conjugate gradient (CG) method instead of the time-consuming matrix inversion method. An almost minimax solution for filter design is consequently obtained. This solution is found to be very efficient compared with most existing algorithms. Moreover, the filtering solution is flexible enough for extension towards a broad range of filter designs, including constrained filters. Two design examples are given and the comparison with other existing algorithms shows the excellent performance of the proposed algorithm.
Absolute air filtering equipment in the nuclear industrie. Design - Safety - Experience
International Nuclear Information System (INIS)
Lucas, J.C.
1977-01-01
The problems encountered in the design of absolute filters (HEPA FILTERS) are presented: glass-fibre filter papers; standards and characteristics: efficiency, fire-resistance, humidity-resistance, radiation-resistance, etc; various types of paper folding: deep folds and small folds, dihedrally mounted; filtering elements; designs; characteristics and quality control; The design of filtration equipment is also analysed: mounting in metal or concrete casings. French and American designs (Regulatory Guide 1-52); and gas-tight casings allowing contaminated filters to be renewed without breaking the gas-tight seal
Criteria for calculating the efficiency of HEPA filters during and after design basis accidents
International Nuclear Information System (INIS)
Bergman, W.; First, M.W.; Anderson, W.L.; Gilbert, H.; Jacox, J.W.
1994-12-01
We have reviewed the literature on the performance of high efficiency particulate air (HEPA) filters under normal and abnormal conditions to establish criteria for calculating the efficiency of HEPA filters in a DOE nonreactor nuclear facility during and after a Design Basis Accident (DBA). The literature review included the performance of new filters and parameters that may cause deterioration in the filter performance such as filter age, radiation, corrosive chemicals, seismic and rough handling, high temperature, moisture, particle clogging, high air flow and pressure pulses. The deterioration of the filter efficiency depends on the exposure parameters; in severe exposure conditions the filter will be structurally damaged and have a residual efficiency of 0%. Despite the many studies on HEPA filter performance under adverse conditions, there are large gaps and limitations in the data that introduce significant error in the estimates of HEPA filter efficiencies under DBA conditions. Because of this limitation, conservative values of filter efficiency were chosen when there was insufficient data
Tay, D H; Kingsbury, N G
1993-01-01
An approach to designing multidimensional linear-phase FIR diamond subband filters having the perfect reconstruction property is presented. It is based on a transformation of variables technique and is equivalent to the generalized McClellan transformation. Methods for designing a whole class of transformation are given. The approach consists of two parts; design of the transformation and design of the 1-D filters. The use of Lagrange halfband filters to design the 1-D filters is discussed. The modification of a particular Lagrange halfband filter which gives a pair of simple 1-D filters that are almost similar to each other in their frequency characteristics but still form a perfect reconstruction pair is presented. The design technique is extended to other types of two-channel sampling lattice and subband shapes, in particular, the parallelogram and the diagonally quadrant subband cases. Several numerical design examples are presented to illustrate the flexibility of the design method.
Design of dual ring wavelength filters for WDM applications
Sathyadevaki, R.; Shanmuga sundar, D.; Sivanantha Raja, A.
2016-12-01
Wavelength division multiplexing plays a prime role in an optical communication due to its advantages such as easy network expansion, longer span lengths etc. In this work, photonic crystal based filters with the dual rings are proposed which act as band pass filters (BPF) and channel drop filter (CDF) that has found a massive applications in C and L-bands used for wavelength selection and noise filtering at erbium doped fiber amplifiers and dense wavelength division multiplexing operation. These filters are formulated on the square lattice with crystal rods of silicon material of refractive index 3.4 which are perforated on an air of refractive index 1. Dual ring double filters (band pass filter and channel drop filter) on single layout possess passing and dropping band of wavelengths in two distinct arrangements with entire band quality factors of 92.09523 & 505.263 and 124.85019 & 456.8633 for the pass and drop filters of initial setup and amended setup respectively. These filters have the high-quality factor with broad and narrow bandwidths of 16.8 nm & 3.04 nm and 12.85 nm & 3.3927 nm. Transmission spectra and band gap of the desired filters is analyzed using Optiwave software suite. Two dual ring filters incorporated on a single layout comprises the size of 15×11 μm which can also be used in the integrated photonic chips for the ultra-compact unification of devices.
Directory of Open Access Journals (Sweden)
Shaeen Kalathil
2018-01-01
Full Text Available A novel approach for the efficient realization of digital channelizers in software defined radios using recombination filter banks is proposed in this paper. Digital channelizer is the core of software defined radio. Computationally efficient design supporting multiple channels with different bandwidths and low complexity are inevitable requirements for the digital channelizers. Recombination filter banks method is used to obtain non-uniform filter banks with rational sampling factors, using a two stage structure. It consists of a uniform filter bank and trans-multiplexer. In this work, the uniform filter bank and trans-multiplexer are designed using cosine modulated filter banks. The prototype filter design is made simple, efficient and fast, using window method. The multiplier-less realization of recombination filter banks in the canonic signed digit space using nature inspired optimization algorithms, results in reduced implementation complexity.
B-spline design of digital FIR filter using evolutionary computation techniques
Swain, Manorama; Panda, Rutuparna
2011-10-01
In the forth coming era, digital filters are becoming a true replacement for the analog filter designs. Here in this paper we examine a design method for FIR filter using global search optimization techniques known as Evolutionary computation via genetic algorithm and bacterial foraging, where the filter design considered as an optimization problem. In this paper, an effort is made to design the maximally flat filters using generalized B-spline window. The key to our success is the fact that the bandwidth of the filer response can be modified by changing tuning parameters incorporated well within the B-spline function. This is an optimization problem. Direct approach has been deployed to design B-spline window based FIR digital filters. Four parameters (order, width, length and tuning parameter) have been optimized by using GA and EBFS. It is observed that the desired response can be obtained with lower order FIR filters with optimal width and tuning parameters.
INEL BNCT Program: Volume 5, No. 9
Energy Technology Data Exchange (ETDEWEB)
Ackermann, A.L. (ed.)
1991-01-01
This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Introducing BNCT treatment in new treatment facilities
International Nuclear Information System (INIS)
Gabel, D.
2001-01-01
The physical and radiobiological studies that should be performed before the initiation of BNCT are discussed. The need for dose-escalation versus response studies in large animal models is questioned. These studies are time consuming, expensive and legally difficult in some countries and may be dispensable. (author)
USING GENETIC ALGORITHMS FOR DESIGNING OF FIR DIGITAL FILTERS
Directory of Open Access Journals (Sweden)
Alireza Rezaee
2010-07-01
Full Text Available In this paper, a new technique is presented for the design and optimization of digital FIR filters with coefficients that are presented in canonic signed-digit (CSD format. Since such implementation requires no multipliers, it reduces the hardware cost and lowers the power consumption. The proposed technique considers three goals, the optimum number of coefficients, the optimum wordlength, and the optimum set of coefficients which satisfies the desirable frequency response and ensures the minimum hardware cost by minimizing the number of nonzero digits in CSD representation of the coefficients using Genetic Algorithms (GA. Comparing with equiripple method, the proposed technique results in about 30-40 percent reduction in hardware cost.
Clinical results of boron neutron capture therapy (BNCT) for glioblastoma
International Nuclear Information System (INIS)
Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, H.
2011-01-01
The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998. The median survival time (MST) of BNCT was 19.5 months, and 2-year, 3-year and 5-year survival rates were 26.1%, 17.4% and 5.8%, respectively. This clinical result of BNCT in patients with GBM is superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment. - Highlights: ► In this study, we evaluate the clinical outcome of boron neutron capture therapy (BNCT) for malignant brain tumors. ► We have treated 23 glioblastoma (GBM) patients with BNCT without any additional chemotherapy. ► Clinical results of BNCT in patients with GBM are superior to that of single treatment of conventional radiotherapy compared with historical data of conventional treatment.
A novel design methodology for low pass filter stage of a voltage ...
Indian Academy of Sciences (India)
Though the attenuation of high frequency components, offered by the higher order filters, has resulted in improved efficiency, the inherent instability of the higher order filter systemsrequires complex controls for proper functioning. Keeping this in mind, the paper describes the design methodology of a second order LC filter ...
Initial Experimental Verification of the Neutron Beam Modeling for the LBNL BNCT Facility
International Nuclear Information System (INIS)
Bleuel, D.L.; Chu, W.T.; Donahue, R.J.; Ludewigt, B.A.; McDonald, R.J.; Smith, A.R.; Stone, N.A.; Vuji, J.
1999-01-01
In preparation for future clinical BNCT trials, neutron production via the 7Li(p,n) reaction as well as subsequent moderation to produce epithermal neutrons have been studied. Proper design of a moderator and filter assembly is crucial in producing an optimal epithermal neutron spectrum for brain tumor treatments. Based on in-phantom figures-of-merit,desirable assemblies have been identified. Experiments were performed at the Lawrence Berkeley National Laboratory's 88-inch cyclotron to characterize epithermal neutron beams created using several microampere of 2.5 MeV protons on a lithium target. The neutron moderating assembly consisted of Al/AlF3 and Teflon, with a lead reflector to produce an epithermal spectrum strongly peaked at 10-20 keV. The thermal neutron fluence was measured as a function of depth in a cubic lucite head phantom by neutron activation in gold foils. Portions of the neutron spectrum were measured by in-air activation of six cadmium-covered materials (Au, Mn, In, Cu, Co, W) with high epithermal neutron absorption resonances. The results are reasonably reproduced in Monte Carlo computational models, confirming their validity
A New Design Method of AC Filter for Static Var Compensator
Tamura, Yuji; Irokawa, Shoichi; Takeda, Hideo; Takagi, Kikuo; Noro, Yasuhiro; Ametani, Akihiro
A new approach of the AC filter design for the SVC (Static Var Compensator) is proposed in this paper. When the SVC consists of TCR(s) (Thyristor Controlled Reactor(s)) or TCT(s) (Thyristor Controlled Transformer(s)) and the AC filter(s), it is required to design AC filter(s) carefully to meet regulation level of harmonic voltage and current at the connection point of the SVC. In general, the AC filter design may require many iterative calculations of the harmonic performance by changing electrical parameters of the AC filter until all the harmonic voltage and current performances at the connection point of the SVC meet the regulation level on various conditions in terms of the filter de-tuning cases and the AC power system conditions. In this respect a new AC filter design approach is proposed, which is innovative on evaluation method of the performance to predetermine the permissible range of the AC filter harmonic impedance on the complex plane. By using this method, the iterations of the calculation can be reduced and it enables more efficient process of the design providing clear accountability of the decision of AC filter parameters.
Optimal design on digital filter algorithm of Hankel transform
Zhao, Yun-wei; Zhu, Zi-qiang; Lu, Guang-yin; Li, Jian-hui
2017-11-01
This study investigates the influence of the parameter c of Hankel transform pairs and sampling interval s on the digital filter of Hankel transform based on the idea of Hankel digital filtering algorithm proposed by Kong. The results show that the selection of the parameter c highly influence the precision of digital filter algorithm, i.e., an inappropriate c can induce algorithm errors. Upon the optimal selection of the parameter c and the constant length of the digital filter, it is found that an optimal sampling interval s also exists to achieve the best precision of digital filter algorithm. Finally, this study proposes six groups of 0-, 1-order Hankel transform digital filters with different length and promote its application.
Radiobiology studies for the evaluation of epithermal neutron beams used for BNCT
International Nuclear Information System (INIS)
Green, S.; Jones, B.; Mill, A.J.
2006-01-01
This paper outlines our plans for a study to establish the radiobiological effectiveness of the various mixes of radiation components present in an epithermal neutron beam designed for BNCT and to incorporate these data into clinical protocols for the treatment of malignant glioma. This is a description of work which is funded and just now beginning in Birmingham so no results can be presented. Our project will involve a combination of experimental measurements carried out in Birmingham and in Boston and mathematical modelling carried out in Birmingham. Despite all the extant in-vitro and in-vivo work, there is no widely accepted method to determine biological effect by accounting for variations in beam component mix, dose rate and treatment fractionation for disparate from the various BNCT centres. The objectives of this study are: To develop a cell-based radiobiology protocol to provide essential data on safety and efficacy of beams for Boron Neutron Capture Therapy (BNCT) in advance of clinical trials. To exploit the facilities at Massachusetts Institute of Technology for variable dose-rate epithermal irradiations to validate the above protocol. To develop mathematical models of this radiobiological system that can be used to inform decisions on dose selection, fractionation schedules, BNCT use as supplementary boosts or for re-treatment of recurrent cancers. To provide fundamental data relevant to the understanding of the radiobiology of simultaneous mixed high-and low-LET radiations over a clinically relevant dose-range. (author)
Rajan, P. K.; Khan, Ajmal
1993-01-01
Spatial light modulators (SLMs) are being used in correlation-based optical pattern recognition systems to implement the Fourier domain filters. Currently available SLMs have certain limitations with respect to the realizability of these filters. Therefore, it is necessary to incorporate the SLM constraints in the design of the filters. The design of a SLM-constrained minimum average correlation energy (SLM-MACE) filter using the simulated annealing-based optimization technique was investigated. The SLM-MACE filter was synthesized for three different types of constraints. The performance of the filter was evaluated in terms of its recognition (discrimination) capabilities using computer simulations. The correlation plane characteristics of the SLM-MACE filter were found to be reasonably good. The SLM-MACE filter yielded far better results than the analytical MACE filter implemented on practical SLMs using the constrained magnitude technique. Further, the filter performance was evaluated in the presence of noise in the input test images. This work demonstrated the need to include the SLM constraints in the filter design. Finally, a method is suggested to reduce the computation time required for the synthesis of the SLM-MACE filter.
The Design of Polymer Planar Optical Triplexer with MMI Filter and Directional Coupler
Directory of Open Access Journals (Sweden)
V. Jerabek
2013-12-01
Full Text Available Optical bidirectional WDM transceiver is a key component of the Passive Optical Network of the Fiber to the Home topology. Essential parts of such transceivers are filters that combine multiplexing and demultiplexing function of optical signal (triplexing filters. In this paper we report about a design of a new planar optical multi-wavelength selective system triplexing filter, which combines a multimode interference filter with directional coupler based on the epoxy polymer SU-8 on Si/SiO2 substrate. The optical triplexing filter was designed using the Beam Propagation Method. The aim of this project was to optimize the triplexing filter optical parameters and to minimize the planar optical wavelength selective system dimensions. The multimode interference filter was used for separation of downstream optical signal in designed optoelectronic integrated WDM transceiver. The directional coupler was used for adding of upstream optical signal.
Design and control of an LCL-filter-based three-phase active rectifier
DEFF Research Database (Denmark)
Liserre, Marco; Blaabjerg, Frede; Hansen, Steffan
2005-01-01
This paper proposes a step-by-step procedure for designing the LCL filter of a front-end three-phase active rectifier. The primary goal is to reduce the switching frequency ripple at a reasonable cost, while at the same time achieving a high-performance front-end rectifier (as characterized...... by a rapid dynamic response and good stability margin). An example LCL filter design is reported and a filter has been built and tested using the values obtained from this design. The experimental results demonstrate the performance of the design procedure both for the LCL filter and for the rectifier...... a powerful tool to design an LCL-filter-based active rectifier while avoiding trial-and-error procedures that can result in having to build several filter prototypes....
IIR digital filter design for powerline noise cancellation of ECG signal using arduino platform
Rahmatillah, Akif; Ataulkarim
2017-05-01
Powerline noise has been one of significant noises of Electrocardiogram (ECG) signal measurement. This noise is characterized by a sinusoidal signal which has 50 Hz of noise and 0.3 mV of maximum amplitude. This paper describes the design of IIR Notch filter design to reject a 50 Hz power line noise. IIR filter coefficients were calculated using pole placement method with three variations of band stop cut off frequencies of (49-51)Hz, (48 - 52)Hz, and (47 - 53)Hz. The algorithm and coefficients of filter were embedded to Arduino DUE (ARM 32 bit microcontroller). IIR notch filter designed has been able to reject power line noise with average square of error value of 0.225 on (49-51) Hz filter design and 0.2831 on (48 - 52)Hz filter design.
Filter design of eight order butterworth infinite impulse response for earthquake sign
Perdana, Yusuf Hadi; Marsono, Agus
2017-07-01
Filtering is an important procedure in modern seismology analysis to obtain the best quality result in advanced process. There are many programs of signal processing consisting of signal filtering features, for example Seismic Analysis Code (SAC). Unfortunately, the basic mathematical equations in signal processing are not explained in detail. This research has purposes to design a Butterworth filter and to examine the influence of increasing order on the arrival time, polarity, and first motion amplitude of seismic wave. Filter design was done by computing eight order lowpass analog transfer functions and transforming them into lowpass, highpass, and bandpass digital using bilinear transformation so we have recursive and causal filters. The designed filter was then validated by the result of SAC. Based on the research we have found that the method and algorithm of designed filter are consistent with SAC. Increasing filter order can clarify the phases of seismic wave positions. On the other hand, it can influence the phase delay and impulse attenuation of seismic waves. The implication of this effects are error on computation of earthquake parameter and source mechanism. Filter instability due to increasing order will quickly occur if the cutoff frequency range is short or the sampling frequency is high. An appropriate passband frequency at low filter order can optimally generate earthquake filtered waves.
Designing a Wien Filter Model with General Particle Tracer
Mitchell, John; Hofler, Alicia
2017-09-01
The Continuous Electron Beam Accelerator Facility injector employs a beamline component called a Wien filter which is typically used to select charged particles of a certain velocity. The Wien filter is also used to rotate the polarization of a beam for parity violation experiments. The Wien filter consists of perpendicular electric and magnetic fields. The electric field changes the spin orientation, but also imposes a transverse kick which is compensated for by the magnetic field. The focus of this project was to create a simulation of the Wien filter using General Particle Tracer. The results from these simulations were vetted against machine data to analyze the accuracy of the Wien model. Due to the close agreement between simulation and experiment, the data suggest that the Wien filter model is accurate. The model allows a user to input either the desired electric or magnetic field of the Wien filter along with the beam energy as parameters, and is able to calculate the perpendicular field strength required to keep the beam on axis. The updated model will aid in future diagnostic tests of any beamline component downstream of the Wien filter, and allow users to easily calculate the electric and magnetic fields needed for the filter to function properly. Funding support provided by DOE Office of Science's Student Undergraduate Laboratory Internship program.
Non-linear and signal energy optimal asymptotic filter design
Directory of Open Access Journals (Sweden)
Josef Hrusak
2003-10-01
Full Text Available The paper studies some connections between the main results of the well known Wiener-Kalman-Bucy stochastic approach to filtering problems based mainly on the linear stochastic estimation theory and emphasizing the optimality aspects of the achieved results and the classical deterministic frequency domain linear filters such as Chebyshev, Butterworth, Bessel, etc. A new non-stochastic but not necessarily deterministic (possibly non-linear alternative approach called asymptotic filtering based mainly on the concepts of signal power, signal energy and a system equivalence relation plays an important role in the presentation. Filtering error invariance and convergence aspects are emphasized in the approach. It is shown that introducing the signal power as the quantitative measure of energy dissipation makes it possible to achieve reasonable results from the optimality point of view as well. The property of structural energy dissipativeness is one of the most important and fundamental features of resulting filters. Therefore, it is natural to call them asymptotic filters. The notion of the asymptotic filter is carried in the paper as a proper tool in order to unify stochastic and non-stochastic, linear and nonlinear approaches to signal filtering.
All-Pole Recursive Digital Filters Design Based on Ultraspherical Polynomials
Directory of Open Access Journals (Sweden)
N. Stojanovic
2014-09-01
Full Text Available A simple method for approximation of all-pole recursive digital filters, directly in digital domain, is described. Transfer function of these filters, referred to as Ultraspherical filters, is controlled by order of the Ultraspherical polynomial, nu. Parameter nu, restricted to be a nonnegative real number (nu ≥ 0, controls ripple peaks in the passband of the magnitude response and enables a trade-off between the passband loss and the group delay response of the resulting filter. Chebyshev filters of the first and of the second kind, and also Legendre and Butterworth filters are shown to be special cases of these allpole recursive digital filters. Closed form equations for the computation of the filter coefficients are provided. The design technique is illustrated with examples.
International Nuclear Information System (INIS)
Molinari, Ana J.; Pozzi, Emiliano C.C.; Hughes, Andrea Monti; Heber, Elisa M.; Garabalino, Marcela A.; Thorp, Silvia I.; Miller, Marcelo; Itoiz, Maria E.; Aromando, Romina F.; Nigg, David W.; Quintana, Jorge; Santa Cruz, Gustavo A.; Trivillin, Veronica A.; Schwint, Amanda E.
2011-01-01
In the present study we evaluated the therapeutic effect and/or potential radiotoxicity of the novel 'Tandem' Boron Neutron Capture Therapy (T-BNCT) for the treatment of oral cancer in the hamster cheek pouch model at RA-3 Nuclear Reactor. Two groups of animals were treated with 'Tandem BNCT', i.e. BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (T-24h-BNCT) or 48 h (T-48h-BNCT) later. A total tumor dose-matched single application of BNCT mediated by BPA and GB-10 administered jointly ((BPA + GB-10)-BNCT) was administered to an additional group of animals. At 28 days post-treatment, T-24h-BNCT and T-48h-BNCT induced, respectively, overall tumor control (OTC) of 95% and 91%, with no statistically significant differences between protocols. Tumor response for the single application of (BPA + GB-10)-BNCT was 75%, significantly lower than for T-BNCT. The T-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47% and 60% of the animals respectively. No normal tissue radiotoxicity was associated to tumor control for any of the protocols. 'Tandem' BNCT enhances tumor control in oral cancer and reduces or, at worst, does not increase, mucositis in dose-limiting precancerous tissue.
In Vivo Evaluation of Vena Caval Filters: Can Function Be Linked to Design Characteristics?
International Nuclear Information System (INIS)
Proctor, Mary C.; Cho, Kyung J.; Greenfield, Lazar J.
2000-01-01
Purpose: To compare the five vena caval filters marketed in the United States and one investigational vena caval filter and to determine whether there is an association between their design and their in vivo function.Methods: Four of each type of filter-Simon Nitinol (SN), Bird's Nest (BN), Vena Tech (VT), Greenfield stainless steel (PSGF), Greenfield titanium (TGF), and the investigational stent cone filter (NGF)-were studied for 60 days in 12 sheep. Radiographic and pathologic outcomes to be assessed included clot capture and resolution, vena caval penetration, position of the filter, thrombogenicity, and vessel wall reaction.Results: Filters differed with respect to the number of clot-trapping levels and the interdependence of the legs. All devices were successfully placed. Intentionally embolized clot was captured. One VT and two SN filters migrated in response to clot capture. Resolution of thrombus was variable, and related to the design of the device. Fibrin webbing was widely present with the VT, BN, and SN filters but limited in the others. The VT and NGF filters demonstrated the most stable filter base diameter.Conclusions: The performance of vena caval filters differs with respect to clot resolution and mechanical stability. Interdependent filter limbs and single-stage conical capture sites appear to result in more favorable performance in in vivo studies
Differential Mode EMI Filter Design for Isolated DC-DC Boost Converter
DEFF Research Database (Denmark)
Makda, Ishtiyaq Ahmed; Nymand, Morten
2014-01-01
A Differential Mode EMI filter for a low input voltage high-current isolated dc-dc boost converter is designed and presented in this paper. The primary side Differential Mode noise voltage is low due to the high transformer turn ratio, however, the input current is very high and since the EMI limit...... also does not change for such converters, it requires greatly optimized design approach for the filter including the correct sizing of the filter components. A complete analytical filter design process is carried out such a way that the Differential Mode noise voltage source in the converter...... is identified first. The DM noise model is then established and based on the harmonic analysis of the noise source voltage waveform, the complete Differential Mode EMI filter, including the filter resonance damping branch, is designed for a 3kW isolated dc-dc boost converter. The noise model and its theoretical...
Pupil filter design by using a Bessel functions basis at the image plane.
Canales, Vidal F; Cagigal, Manuel P
2006-10-30
Many applications can benefit from the use of pupil filters for controlling the light intensity distribution near the focus of an optical system. Most of the design methods for such filters are based on a second-order expansion of the Point Spread Function (PSF). Here, we present a new procedure for designing radially-symmetric pupil filters. It is more precise than previous procedures as it considers the exact expression of the PSF, expanded as a function of first-order Bessel functions. Furthermore, this new method presents other advantages: the height of the side lobes can be easily controlled, it allows the design of amplitude-only, phase-only or hybrid filters, and the coefficients of the PSF expansion can be directly related to filter parameters. Finally, our procedure allows the design of filters with very different behaviours and optimal performance.
Directory of Open Access Journals (Sweden)
Te-Jen Su
2007-01-01
Full Text Available In this letter, clonal selection algorithm (CSA with singular value decomposition (SVD method is investigated for the realization of two-dimentional (2D infinite-impulse response (IIR filters with arbitrary magnitude responses. The CSA is applied to optimize the sampled frequencies of transition band of digital filters, then producing a planar response matrix of a 2D IIR digital filter. By using the SVD, 2D magnitude specifications can be decomposed into a pair of 1D filters, and thus the problem of designing a 2D digital filter can be reduced to the one of designing a pair of 1D digital filters or even only one 1D digital filter. The stimulation results show the proposed method has the better performance of the minimum attenuation between the passband and stopband.
Mean-square filter design for stochastic polynomial systems with Gaussian and Poisson noises
Basin, Michael; Rodriguez-Ramirez, Pablo
2014-07-01
This paper addresses the mean-square finite-dimensional filtering problem for polynomial system states with both, Gaussian and Poisson, white noises over linear observations. A constructive procedure is established to design the mean-square filtering equations for system states described by polynomial equations of an arbitrary finite degree. An explicit closed form of the designed filter is obtained in case of a third-order polynomial system. The theoretical result is complemented with an illustrative example verifying performance of the designed filter.
Min-Max Design of FIR Digital Filters by Semidefinite Programming
Nagahara, Masaaki
2013-01-01
In this article we consider two problems: FIR (Finite Impulse Response) approximation of IIR (Infinite Impulse Response) filters and inverse FIR filtering of FIR or IIR filters. By means of Kalman-Yakubovich-Popov (KYP) lemma and its generalization (GKYP), the problems are reduced to semidefinite programming described in linear matrix inequalities (LMIs). MATLAB codes for these design methods are given. An design example shows the effectiveness of these methods.
Severe Accident Analysis for Containment Filtered Venting System Design
Energy Technology Data Exchange (ETDEWEB)
Bang, Young Suk; Park, Tong Kyu; Lee, Doo Yong; Lee, Byung Chul [FNC Technology Co. Ltd, Yongin (Korea, Republic of); Lee, Sang Won; Kim, Hyeong Taek [KHNP-Central Research Institute, Daejeon (Korea, Republic of)
2014-05-15
Basic idea of containment venting is to relieve the pressure inside of the containment by establishing a flow path to the external environment. After TMI accident, many countries (Sweden, Germany, France) requires containment venting system like FCVS (filtered containment venting system), which can allow for the release of the over-pressure through a scrubber normally containing water and chemicals to reduce the radioactive material releases to the environment. It is also important to optimize the vent line size to prevent additional risk of leakage and to install at the site with limited space availability. This study examines the thermodynamic behavior due to different vent strategies for a large PWR during severe accidents for the OPR1000 Korea nuclear power plant. The representative accident scenario is identified and the sensitivity analysis with varying conditions (i. e. vent line size and vent initiation pressure) is conducted by using numerical simulation. The effects of venting during the severe accident with containment pressurization are examined. The accident scenarios are selected by using both of the qualitative judgement and the preliminary calculations and the sensitivity analysis on vent line size and vent initiation timing is conducted. As a result, the general trend of containment behavior due to venting can be found. Summarizing the findings, two conflict trends are found: - The maximum discharged flow rate would be higher as the vent line size and vent opening pressure increases. - The decay heat and the aerosol mass delivered to CFVS would be higher as the vent line size and vent opening pressure decreases. Regarding the flow rate, decay heat and aerosol mass are important factor for CFVS design, it would be necessary to find the optimum design specification with economical and regulatory considerations.
Present status of Accelerator-Based BNCT.
Kreiner, Andres Juan; Bergueiro, Javier; Cartelli, Daniel; Baldo, Matias; Castell, Walter; Asoia, Javier Gomez; Padulo, Javier; Suárez Sandín, Juan Carlos; Igarzabal, Marcelo; Erhardt, Julian; Mercuri, Daniel; Valda, Alejandro A; Minsky, Daniel M; Debray, Mario E; Somacal, Hector R; Capoulat, María Eugenia; Herrera, María S; Del Grosso, Mariela F; Gagetti, Leonardo; Anzorena, Manuel Suarez; Canepa, Nicolas; Real, Nicolas; Gun, Marcelo; Tacca, Hernán
2016-01-01
This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT). There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines. A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development. Endothermic (7)Li(p,n)(7)Be and (9)Be(p,n)(9)B and exothermic (9)Be(d,n)(10)B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. (9)Be(p,n)(9)B needs at least 4-5 MeV bombarding energy to have a sufficient yield, while (9)Be(d,n)(10)B can be utilized at about 1.4 MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs. (7)Li(p,n)(7)Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. (9)Be(d,n)(10)B at 1.4 MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.
Co-design of the LCL Filter and Control for Grid-Connected Inverters
DEFF Research Database (Denmark)
Zhang, Yu; Xue, Mingyu; Li, Minying
2014-01-01
In most grid-connected inverters (GCI) with an LCL filter, since the design of both the LCL filter and the controller is done separately, considerable tuning efforts have to be exerted when compared to inverters using an L filter. Consequently, an integrated co-design of the filter and the contro......In most grid-connected inverters (GCI) with an LCL filter, since the design of both the LCL filter and the controller is done separately, considerable tuning efforts have to be exerted when compared to inverters using an L filter. Consequently, an integrated co-design of the filter...... and the controller for an LCL-type GCI is proposed in this paper. The control strategy includes only a PI current controller and a proportional grid voltage feed-forward controller. The capacitor is removed from the LCL filer and the design procedure starts from an L-type GCI with a PI current controller. After...... the PI controller has been settled, the capacitor is added back to the filter. Hence, it introduces a resonance frequency, which is identified based on the crossover frequencies to accommodate the preset PI controller. Using the proposed co-design method, harmonic standards are satisfied and other...
An accelerator neutron source for BNCT. Technical progress report, 1 June 1993--31 May 1994
International Nuclear Information System (INIS)
Blue, T.E.; Vafai, K.
1994-02-01
This is the progress report for the project entitled, ''An Accelerator Neutron Source for BNCT.'' The progress report is for the period from July 1, 1993 to date. The overall objective of our research project is to develop an Accelerator Epithermal Neutron Irradiation Facility (AENIF) for Boron Neutron Capture Therapy (BNCT). The AENIF consists of a 2.5 MeV high current proton accelerator, a lithium target to produce source neutrons, and a moderator/reflector assembly to obtain from the energetic source neutrons an epithermal neutron field suitable for BNCT treatments. Our project goals are to develop the non-accelerator components of the AENIF, and to specifically include in our development: (1) design, numerical simulation, and experimental verification of a target assembly which is capable of removing 75 kW of beam power; (2) re-optimization of the moderator assembly design based on in-phantom dose assessments using neutron spectra calculated in phantom and an energy-dependent neutron Relative Biological Effectiveness (RBE); (3) construction of a prototype moderator assembly and confirmation of its design by measurements; (4) design of the shielding of the accelerator and treatment rooms for an AENIF; and (5) design of a high energy beam transport system which is compatible with the shielding design and the thermal-hydraulic design
Active-Varying Sampling-Based Fault Detection Filter Design for Networked Control Systems
Directory of Open Access Journals (Sweden)
Yu-Long Wang
2014-01-01
Full Text Available This paper is concerned with fault detection filter design for continuous-time networked control systems considering packet dropouts and network-induced delays. The active-varying sampling period method is introduced to establish a new discretized model for the considered networked control systems. The mutually exclusive distribution characteristic of packet dropouts and network-induced delays is made full use of to derive less conservative fault detection filter design criteria. Compared with the fault detection filter design adopting a constant sampling period, the proposed active-varying sampling-based fault detection filter design can improve the sensitivity of the residual signal to faults and shorten the needed time for fault detection. The simulation results illustrate the merits and effectiveness of the proposed fault detection filter design.
Energy Technology Data Exchange (ETDEWEB)
Ana J. Molinari; Emiliano C. C. Pozzi; Andrea Monti Hughes; Elisa M. Heber; Marcela A. Garabalino; Silvia I. Thorp; Marcelo Miller; Maria E. Itoiz; Romina F. Aromando; David W. Nigg; Jorge Quintana; Gustavo A. Santa Cruz; Veronica A. Trivillin; Amanda E. Schwint
2011-04-01
In the present study we evaluated the therapeutic effect and/or potential radiotoxicity of the novel “Tandem” Boron Neutron Capture Therapy (T-BNCT) for the treatment of oral cancer in the hamster cheek pouch model at RA-3 Nuclear Reactor. Two groups of animals were treated with “Tandem BNCT”, i.e. BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (T-24h-BNCT) or 48 h (T-48h-BNCT) later. A total tumor dose-matched single application of BNCT mediated by BPA and GB-10 administered jointly [(BPA + GB-10)-BNCT] was administered to an additional group of animals. At 28 days post-treatment, T-24h-BNCT and T-48h-BNCT induced, respectively, overall tumor control (OTC) of 95% and 91%, with no statistically significant differences between protocols. Tumor response for the single application of (BPA + GB-10)-BNCT was 75%, significantly lower than for T-BNCT. The T-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47% and 60% of the animals respectively. No normal tissue radiotoxicity was associated to tumor control for any of the protocols. “Tandem” BNCT enhances tumor control in oral cancer and reduces or, at worst, does not increase, mucositis in dose-limiting precancerous tissue.
Design of correlation filters for pattern recognition with disjoint reference image
Aguilar-González, Pablo Mario; Kober, Vitaly
2011-11-01
Correlation filters for pattern recognition are commonly designed under the assumption that the shape and appearance of an object of interest are explicitly known. In this paper, we consider a signal model in which an object of interest is given at unknown coordinates in a cluttered reference image and corrupted by additive noise. The reference image is used to design filters for detecting a target in scenes with a nonoverlapping background and additive noise. An optimum correlation filter with respect to peak-to-output energy for object detection is derived. The shape and appearance of the target are estimated from the reference image. Two methods to estimate the frequency response of the derived filter are used. Computer simulation results obtained with the proposed filters are presented and discussed. The performance of the filters is evaluated in terms of discrimination capability and location accuracy for different statistics of the backgrounds and noise processes present in the signal model.
Improved High-Heat-Load Graphite Filter Design At CHESS Wiggler Beamlines
International Nuclear Information System (INIS)
Savino, James J.; Shen Qun; Strieter, Gretchen; Fontes, Ernest; Pauling, Alan K.
2004-01-01
Conductively cooled highly-oriented pyrolytic graphite (HOPG) filters have been used at CHESS wiggler beamlines to protect downstream beryllium windows under high heat loads. In the past beam currents above 350 mA have caused excessively high temperatures on the existing HOPG filters, resulting in rapid sublimation of the graphite and drastic shortening of filter lifetimes. A new filter design which eliminates some drawbacks of the existing design is described. The new design utilizes a slotted water jet, which cools a thin, 'compliant' graphite-copper braze joint. Heat-transfer enhancements should enable an installed filter to survive beam currents of 450 mA. Optimization of design features and analysis results are discussed
The studsvik BNCT project: structure and the proposed protocols
International Nuclear Information System (INIS)
Capala, J.; Stenstam, B.H.; Skoeld, K.; Henriksson, R.; Salford, L.; Carlsson, J.
2000-01-01
The BNCT facility at Studsvik is now ready for clinical trials. Scientific operations of the Studsvik BNCT project are overseen by the Scientific Advisory Board comprised of representatives of all major universities in Sweden. Furthermore, special task groups for clinical and preclinical studies have been formed to facilitate collaboration with academia and to assure the quality of the research. Proposed clinical Phase II trials for glioblastoma are sponsored by the Swedish National Neuro-Oncology Group and, initially, will involve two protocols: Protocol no.1. BNCT for glioblastoma patients who have not received any therapy other than surgery (including stereotactic biopsy only). Protocol no.2. BNCT as a palliative treatment for patients with recurrent glioblastoma following conventional therapies or BNCT. In both protocols, BPA, administered by a 6 hour i.v. infusion, will be used as the boron delivery agent. (author)
Performance and environmental characteristics of a compact, high-capacity HEPA filter design
International Nuclear Information System (INIS)
Rose, C.E.; Rivers, R.D.
1979-01-01
An improved version of the HEPA filter has been developed and evaluated for conformity with MIL-51068. In this design, the filter paper (conforming to MIL-F-51079) is pleated to a depth of only 18 mm. Ribbons essentially the same material as the filter paper form inter-pleat spacers, providing a crest-to-crest spacing of 3 mm. The resultant filter has the same DOP penetration level as the standard MIL-F-51068 HEPA filter, but about half its pressure drop at the same airflow. Materials of construction, adhesives, gaskets and faceguards match MIL-f-51068. Both flat-panel and zig-zag configurations of the filter meet the rough handling test of MIL-F-51068. Preliminary indications are that both filters will meet the overpressure tests of MIL-F-51068D and the flammability requirements of UL 586; these tests are in progress. Filters can be supplied to interchange with existing HEPA filter sizes. The improved pressure drop characteristic of these filters can be used to provide longer intervals between filter changes, or equal life at greater capacity
Design and Efficiency Analysis of one Class of Uniform Linear Phase FIR Filter Banks
Directory of Open Access Journals (Sweden)
R. D. Pantić
2013-11-01
Full Text Available One class of uniform linear phase filter banks with different numbers of band-pass channels will be considered in this study, concentrating on 5, 9 and 17-band filter banks and their mutual comparison concerning delay and implementation complexity. Designed banks are based on the FIR filters and frequency response masking technique and are also compared to the banks with direct realization considering complementarity and delay.
New high-Q discrete-time LC bandpass filter design with center frequency broadband tuning
El Oualkadi, Ahmed; Paillot, Jean-Marie; Allam, Rachid
2006-01-01
International audience; Discrete-time switched-capacitor filters have been in wide-spread used for a few years, for the realization of stable, accurate and high quality filters. This paper describes the design of a new 8-path pseudo switched capacitor LC bandpass filter and its command circuit made up by a ring voltage controlled oscillator (VCO) with 'XOR' gates. The proposed architecture presents the possibility of tuning over a frequency broadband allowing to sweep different channels with ...
Design and realization of a two-stage microring ladder filter in silicon-on-insulator.
Masilamani, A P; Van, V
2012-10-22
We report the design and experimental realization of a new type of microring filters consisting of two parallel-cascaded microring doublets connected by a π-phase shift element. Interference between the two second-order microring stages gave rise to a fourth-order filter response with flat-top passband and a bandwidth of 100 GHz. The result demonstrates the feasibility of realizing advanced integrated optics filters based on parallel cascades of high-order microring networks.
Design of Absorbing Wave Maker based on Digital Filters
DEFF Research Database (Denmark)
Christensen, Morten; Frigaard, Peter
An absorbing wave maker operated by means of on-line signals from digital FIR filters is presented. Surface elevations are measured in two positions in front of the wave maker. The reflected wave train is seperated by the sum of the incident and reflected wave trains by means of digital filtering...... and subsequent superposition of the measured surface elevations. The motion of the wave paddle required to absorb reflected waves is determined and added to the original wave paddle control signal. Irregular wave tests involving test structures with different degrees of reflection show that excellent absorption...
The design of trickling biological periwinkle shells filter for closed ...
African Journals Online (AJOL)
... water quality parameters such as DO, pH, temperature, BOD5, Seechi transparency, total alkalinity, free carbon dioxide, chloride, etc. in the treatment system were not significantly (p>0.05) different from that of the control system. We concluded that periwinkle shell is a suitable trickling filter medium for closed recirculation ...
Designing organic spin filters in the coherent tunneling regime.
Herrmann, Carmen; Solomon, Gemma C; Ratner, Mark A
2011-06-14
Spin filters, that is, systems which preferentially transport electrons of a certain spin orientation, are an important element for spintronic schemes and in chemical and biological instances of spin-selective electronic communication. We study the relation between molecular structure and spin filtering functionality employing a theoretical analysis of both model and stable organic radicals based on substituted benzene, which are bound to gold electrodes, with a combination of density functional theory and the Landauer-Imry-Büttiker approach. We compare the spatial distribution of the spin density and of the frontier central subsystem molecular orbitals, and local contributions to the transmission. Our results suggest that the delocalization of the singly occupied molecular orbital and of the spin density onto the benzene ring connected to the electrodes, is a good, although not the sole indicator of spin filtering functionality. The stable radicals under study do not effectively act as spin filters, while the model phenoxy-based radicals are effective due to their much larger spin delocalization. These conclusions may also be of interest for electron transfer experiments in electron donor-bridge-acceptor complexes.
Design of an S band narrow-band bandpass BAW filter
Gao, Yang; Zhao, Kun-li; Han, Chao
2017-11-01
An S band narrowband bandpass filter BAW with center frequency 2.460 GHz, bandwidth 41MHz, band insertion loss - 1.154 dB, the passband ripple 0.9 dB, the out of band rejection about -42.5dB@2.385 GHz; -45.5dB@2.506 GHz was designed for potential UAV measurement and control applications. According to the design specifications, the design is as follows: each FBAR's stack was designed in BAW filter by using Mason model. Each FBAR's shape was designed with the method of apodization electrode. The layout of BAW filter was designed. The acoustic-electromagnetic cosimulation model was built to validate the performance of the designed BAW filter. The presented design procedure is a common one, and there are two characteristics: 1) an A and EM co-simulation method is used for the final BAW filter performance validation in the design stage, thus ensures over-optimistic designs by the bare 1D Mason model are found and rejected in time; 2) An in-house developed auto-layout method is used to get compact BAW filter layout, which simplifies iterative error-and-try work here and output necessary in-plane geometry information to the A and EM cosimulation model.
Hintzen, E.; Vennemann, T.; Mathis, W.
2014-11-01
In this paper a new filter design concept is proposed and implemented which takes into account the complex loudspeaker impedance. By means of techniques of broadband matching, that has been successfully applied in radio technology, we are able to optimize the reconstruction filter to achieve an overall linear frequency response. Here, a passive filter network is inserted between source and load that matches the complex load impedance to the complex source impedance within a desired frequency range. The design and calculation of the filter is usually done using numerical approximation methods which are known as Real Frequency Techniques (RFT). A first approach to systematic design of reconstruction filters for class-D amplifiers is proposed, using the Simplified Real Frequency Technique (SRFT). Some fundamental considerations are introduced as well as the benefits and challenges of impedance matching between class-D amplifiers and loudspeakers. Current simulation data using MATLAB is presented and supports some first conclusions.
ACTIVE FILTER HARDWARE DESIGN and PERFORMANCE FOR THE DIII-D PLASMA CONTROL SYSTEM
International Nuclear Information System (INIS)
SELLERS, D.; FERRON, J.R; WALKER, M.L; BROESCH, J.D
2004-03-01
OAK-B135 The digital plasma control system (PCS), currently in operation on the DIII-D tokamak, requires inputs from a large number of sensors. Due to the nature of the digitizers and the relative noisy environment from which these signals are derived, each of the 32 signals must be conditioned via an active filter. Two different types of filters, Chebyshev and Bessel with fixed frequencies: 100 Hz Bessel was used for filtering the motional Stark effect diagnostic data. 800 Hz Bessel was designed to filter plasma control data and 1200 Hz Chebyshev is used with closed loop control of choppers. The performance of the plasma control system is greatly influenced by how well the actual filter responses match the software model used in the control system algorithms. This paper addresses the various issues facing the designer in matching the electrical design with the theoretical
Iterative design of one- and two-dimensional FIR digital filters. [Finite duration Impulse Response
Suk, M.; Choi, K.; Algazi, V. R.
1976-01-01
The paper describes a new iterative technique for designing FIR (finite duration impulse response) digital filters using a frequency weighted least squares approximation. The technique is as easy to implement (via FFT) and as effective in two dimensions as in one dimension, and there are virtually no limitations on the class of filter frequency spectra approximated. An adaptive adjustment of the frequency weight to achieve other types of design approximation such as Chebyshev type design is discussed.
Design of efficient circularly symmetric two-dimensional variable digital FIR filters.
Bindima, Thayyil; Elias, Elizabeth
2016-05-01
Circularly symmetric two-dimensional (2D) finite impulse response (FIR) filters find extensive use in image and medical applications, especially for isotropic filtering. Moreover, the design and implementation of 2D digital filters with variable fractional delay and variable magnitude responses without redesigning the filter has become a crucial topic of interest due to its significance in low-cost applications. Recently the design using fixed word length coefficients has gained importance due to the replacement of multipliers by shifters and adders, which reduces the hardware complexity. Among the various approaches to 2D design, transforming a one-dimensional (1D) filter to 2D by transformation, is reported to be an efficient technique. In this paper, 1D variable digital filters (VDFs) with tunable cut-off frequencies are designed using Farrow structure based interpolation approach, and the sub-filter coefficients in the Farrow structure are made multiplier-less using canonic signed digit (CSD) representation. The resulting performance degradation in the filters is overcome by using artificial bee colony (ABC) optimization. Finally, the optimized 1D VDFs are mapped to 2D using generalized McClellan transformation resulting in low complexity, circularly symmetric 2D VDFs with real-time tunability.
Equalization of Loudspeaker and Room Responses Using Kautz Filters: Direct Least Squares Design
Directory of Open Access Journals (Sweden)
Tuomas Paatero
2007-01-01
Full Text Available DSP-based correction of loudspeaker and room responses is becoming an important part of improving sound reproduction. Such response equalization (EQ is based on using a digital filter in cascade with the reproduction channel to counteract the response errors introduced by loudspeakers and room acoustics. Several FIR and IIR filter design techniques have been proposed for equalization purposes. In this paper we investigate Kautz filters, an interesting class of IIR filters, from the point of view of direct least squares EQ design. Kautz filters can be seen as generalizations of FIR filters and their frequency-warped counterparts. They provide a flexible means to obtain desired frequency resolution behavior, which allows low filter orders even for complex corrections. Kautz filters have also the desirable property to avoid inverting dips in transfer function to sharp and long-ringing resonances in the equalizer. Furthermore, the direct least squares design is applicable to nonminimum-phase EQ design and allows using a desired target response. The proposed method is demonstrated by case examples with measured and synthetic loudspeaker and room responses.
New optimal design method for trap damping sections in grid-connected LCL filters
DEFF Research Database (Denmark)
Beres, Remus Narcis; Wang, Xiongfei; Blaabjerg, Frede
2014-01-01
be the case. The choice of the traps parameters in case of adopting multi-tuned traps is systematically described. By using the proposed method, the size of the damping elements and the quality factor of the filter are very easy to be calculated by the filter designer. Time-domain and frequency domain...
Optimal Design of Passive Power Filters Based on Pseudo-parallel Genetic Algorithm
Li, Pei; Li, Hongbo; Gao, Nannan; Niu, Lin; Guo, Liangfeng; Pei, Ying; Zhang, Yanyan; Xu, Minmin; Chen, Kerui
2017-05-01
The economic costs together with filter efficiency are taken as targets to optimize the parameter of passive filter. Furthermore, the method of combining pseudo-parallel genetic algorithm with adaptive genetic algorithm is adopted in this paper. In the early stages pseudo-parallel genetic algorithm is introduced to increase the population diversity, and adaptive genetic algorithm is used in the late stages to reduce the workload. At the same time, the migration rate of pseudo-parallel genetic algorithm is improved to change with population diversity adaptively. Simulation results show that the filter designed by the proposed method has better filtering effect with lower economic cost, and can be used in engineering.
A New Filter Design Method for Disturbed Multilayer Hopfield Neural Networks
Directory of Open Access Journals (Sweden)
AHN, C. K.
2011-05-01
Full Text Available This paper investigates the passivity based filtering problem for multilayer Hopfield neural networks with external disturbance. A new passivity based filter design method for multilayer Hopfield neural networks is developed to ensure that the filtering error system is exponentially stable and passive from the external disturbance vector to the output error vector. The unknown gain matrix is obtained by solving a linear matrix inequality (LMI, which can be easily facilitated by using some standard numerical packages. An illustrative example is given to demonstrate the effectiveness of the proposed filter.
Efficient design of FIR filter based low-pass differentiators for biomedical signal processing
Directory of Open Access Journals (Sweden)
Wulf Michael
2016-09-01
Full Text Available This paper describes an alternative design of linear phase low-pass differentiators with a finite impulse response (type III FIR filter. To reduce the number of necessary filter coefficients, the differentiator’s transfer function is approximated by a Fourier series of a triangle function. Thereby the filter’s transition steepness towards the stopband is intentionally reduced. It can be shown that the proposed design of low-pass differentiators yields to similar results as other published design recommendations, while the filter order can be significantly reduced.
Design of LLCL-filter for grid-connected converter to improve stability and robustness
DEFF Research Database (Denmark)
Huang, Min; Wang, Xiongfei; Loh, Poh Chiang
2015-01-01
The LLCL-filter has recently emerged into gridconnected converters due to the improved filtering capability which ensuring a smaller physical size. An LLCL -based gridconnected converter has almost the same frequency-response characteristic as that with the traditional LCL-filter within half...... of the switching frequency range. The resonance frequencies of the LLCL-filters based grid-connected converters are sensitive to the grid impedance as well as cable capacitance, which may influence the stability of the overall system. This paper proposes a new parameter design method for LLCL-filter from the point...... for LLCL-filter is given. Both simulations and experimental results are provided through a 5 kW, 380V/50 Hz grid-connected inverter model to validate the theoretical analysis in this paper....
A novel optimized LCL-filter designing method for grid connected converter
DEFF Research Database (Denmark)
Guohong, Zeng; Rasmussen, Tonny Wederberg; Teodorescu, Remus
2010-01-01
This paper presents a new LCL-filters optimized designing method for grid connected voltage source converter. This method is based on the analysis of converter output voltage components and inherent relations among LCL-filter parameters. By introducing an optimizing index of equivalent total...... frequency distortion is fulfilled. Compared to the existing methods, the proposed method contains only four steps without try-and-error process, so it is efficient and easy to implement. Simulation results of a 50kVA grid-connected inverter with two sets of LCL-filter parameters under different optimizing...... capacity of all filter components, with clear physical meaning of minimum cost and volume, a set of optimal values of attenuation ratio and inductancesplit- ratio is obtained for deciding all LCL-filter parameters. With this method, filter overall capacity can be minimized while the grid limit of switching...
Carborane-containing metalloporphyrins for BNCT
Energy Technology Data Exchange (ETDEWEB)
Miura, Michiko; Joel, D.D.; Nawrocky, M.M.; Micca, P.L. [and others
1996-12-31
For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be possible if ratios of {sup 10}B concentrations in tumor to those in normal tissue (e.g. brain and blood) were at least 5: 1. Given that the only current boron carrier being tested clinically in the U.S., p-boronophenyl-alanine[BPA], yields tumor blood and tumor brain ratios of about 3:1, the criteria for new boronated compounds should be to at least match these ratios and maintain tumor boron concentrations greater than 30 {mu}g B/g. Although previously tested boronated porphyrins have not only matched but surpassed these ratios, it was at a cost of greater toxicity. Chemical and hematological assays of blood analytes; showed marked thrombocytopenia, a decrease to about one-tenth the normal concentration of platelets circulating in the blood, in addition to abnormalities in concentrations of circulating enzymes, that indicated liver toxicity. The physical appearance and behavior of the affected mice were different from those of mice injected with solvent only. Although thrombocytopenia and other toxic effects had disappeared after a few days, previously tested porphyrins would not be safe to infuse into patients for BNCT of potentially hemorrhagic malignant tumors in the brain such as glioblastoma multiforme and metastatic melanoma. We synthesized a different boronated porphyrin, tetracarboranylphenylporphyrin, [TCP] and inserted nickel, copper, or manganese into its coordination center. Biological studies of NiTCP in mice and of CuTCP in rats show that these compounds elicit little or no toxicity when given at potentially therapeutic doses.
Clinical practice in BNCT to the brain
International Nuclear Information System (INIS)
Nakagawa, Y.
2001-01-01
Our concept of Boron Neutron Capture Therapy (BNCT) is to selectively destroy tumour cells using the high LET particles yielded from the 10B(n,α)7Li reactions. The effort of clinical investigators has concentrated on how to escalate the radiation dose at the target point. BNCT in Japan combines thermal neutrons and BSH (Na 2 B 12 H 11 SH). The radiation dose is determined by the neutron fluence at the target point and the boron concentration in the tumour tissue. According to the recent analysis, the ratio of boron concentration (BSH) in tumour tissue and blood is nearly stable at around 1.2 to 1.69. Escalation of the radiation dose was carried out by means of improving the penetration of the thermal neutron beam. Since 1968, 175 patients with glioblastoma (n=83), anaplastic astrocytoma (n=44), low grade astrocytoma (n=16) or other types of tumour (n=32) were treated by BNCT at 5 reactors (HTR n=13, JRR-3 n=1, MulTR n=98, KUR n=30, JRR-2 n=33). The retrospective analysis revealed that the important factors related to the clinical results and QOL of the patients were minimum tumour volume radiation dose, more than 18Gy of physical dose and maximum vascular radiation dose (less than 15Gy) in the normal cortex. We have planned several trials to escalate the target radiation dose. One trial makes use of a cavity in the cortex following debulking surgery of the tumour tissue to improve neutron penetration. The other trial is introduction of epithermal neutron. KUR and JRR-4 were reconstructed and developed to be able to irradiate using epithermal neutrons. The new combination of surgical procedure and irradiation using epithermal neutrons should remarkably improve the target volume dose compared to the radiation dose treated by thermal neutrons. (author)
Carborane-containing metalloporphyrins for BNCT
International Nuclear Information System (INIS)
Miura, Michiko; Joel, D.D.; Nawrocky, M.M.; Micca, P.L.
1996-01-01
For BNCT of malignant brain tumors, it is crucial that there be relatively high boron concentrations in tumor compared with normal tissues within the neutron-irradiated treatment volume. Fairchild and Bond estimated that major advances in BNCT should be possible if ratios of 10 B concentrations in tumor to those in normal tissue (e.g. brain and blood) were at least 5: 1. Given that the only current boron carrier being tested clinically in the U.S., p-boronophenyl-alanine[BPA], yields tumor blood and tumor brain ratios of about 3:1, the criteria for new boronated compounds should be to at least match these ratios and maintain tumor boron concentrations greater than 30 μg B/g. Although previously tested boronated porphyrins have not only matched but surpassed these ratios, it was at a cost of greater toxicity. Chemical and hematological assays of blood analytes; showed marked thrombocytopenia, a decrease to about one-tenth the normal concentration of platelets circulating in the blood, in addition to abnormalities in concentrations of circulating enzymes, that indicated liver toxicity. The physical appearance and behavior of the affected mice were different from those of mice injected with solvent only. Although thrombocytopenia and other toxic effects had disappeared after a few days, previously tested porphyrins would not be safe to infuse into patients for BNCT of potentially hemorrhagic malignant tumors in the brain such as glioblastoma multiforme and metastatic melanoma. We synthesized a different boronated porphyrin, tetracarboranylphenylporphyrin, [TCP] and inserted nickel, copper, or manganese into its coordination center. Biological studies of NiTCP in mice and of CuTCP in rats show that these compounds elicit little or no toxicity when given at potentially therapeutic doses
Optimization of high speed pipelining in FPGA-based FIR filter design using genetic algorithm
Meyer-Baese, Uwe; Botella, Guillermo; Romero, David E. T.; Kumm, Martin
2012-06-01
This paper compares FPGA-based full pipelined multiplierless FIR filter design options. Comparison of Distributed Arithmetic (DA), Common Sub-Expression (CSE) sharing and n-dimensional Reduced Adder Graph (RAG-n) multiplierless filter design methods in term of size, speed, and A*T product are provided. Since DA designs are table-based and CSE/RAG-n designs are adder-based, FPGA synthesis design data are used for a realistic comparison. Superior results of a genetic algorithm based optimization of pipeline registers and non-output fundamental coefficients are shown. FIR filters (posted as open source by Kastner et al.) for filters in the length from 6 to 151 coefficients are used.
Optimal Design of High-Order Passive-Damped Filters for Grid-Connected Applications
DEFF Research Database (Denmark)
Beres, Remus Narcis; Wang, Xiongfei; Blaabjerg, Frede
2016-01-01
Harmonic stability problems caused by the resonance of high-order filters in power electronic systems are ever increasing. The use of passive damping does provide a robust solution to address these issues, but at the price of reduced efficiency due to the presence of additional passive components....... Hence, a new method is proposed in this paper to optimally design the passive damping circuit for the LCL filters and LCL with multi-tuned LC traps. In short, the optimization problem reduces to the proper choice of the multi-split capacitors or inductors in the high-order filter. Compared to existing...... filter resonance. The passive filters are designed, built and validated both analytically and experimentally for verification....
Robust Design of LCL-Filters for Active Damping in Grid Converters
DEFF Research Database (Denmark)
Alzola, Rafael Pena; Liserre, Marco; Blaabjerg, Frede
2013-01-01
Grid converters require a simple inductor or an LCL-filter to limit the current ripples. The LCL-filter is nowadays the preferred solution as it allows lower inductance values. In order to solve the stability concerns, active damping is preferred to passive damping since it does not use dissipative...... elements. However, large variations in the grid inductance and resonances arising from parallel converters may still compromise the system stability. This calls for a robust design of LCL-filters with active damping. This paper proposes a design flow with little iteration for two well-known methods, namely...... lead-lag network and current capacitor feedback. The proposed formulas for the resonance frequency, grid and converter inductance ratio, and capacitance of the LCL-filter allow calculating all the LCL-filter parameters. An estimation for the achieved Total Harmonic Distortion (THD) of the grid current...
Design of optical finite impulse response filter generating arbitrary spectrum output
Saha, Arijit; Bhattacharya, Kallol; Chakraborty, Ajoy Kumar
2015-06-01
In the present communication, a procedure for the synthesis of an optical finite impulse response (FIR) birefringent filter generating arbitrary spectral output is presented. The basic filter consists of a cascaded system of n identical retarders between two polarizers at the two ends. A mathematical model of the optical FIR filter is introduced using the FIR theory of digital filter design. The parameters determined by the synthesis procedure are the angles of the optic axes of the individual crystals and the angle of the output polarizer. Classical FIR filter design method along with the optical backward transfer technique has been used. Two different arbitrarily specified spectral output profiles have been studied. However, the method is equally applicable for any periodic transfer function whose corresponding impulse response is real and causal.
The Phase I/II BNCT Trials at the Brookhaven medical research reactor: Critical considerations
International Nuclear Information System (INIS)
Diaz, A.Z.
2001-01-01
A phase I/II clinical trial of boronophenylalanine-fructose (BPA-F) mediated boron neutron capture therapy (BNCT) for Glioblastoma Multiforme (GBM) was initiated at Brookhaven National Laboratory (BNL) in 1994. Many critical issues were considered during the design of the first of many sequential dose escalation protocols. These critical issues included patient selection criteria, boron delivery agent, dose limits to the normal brain, dose escalation schemes for both neutron exposure and boron dose, and fractionation. As the clinical protocols progressed and evaluation of the tolerance of the central nervous system (CNS) to BPA-mediated BNCT at the BMRR continued new specifications were adopted. Clinical data reflecting the progression of the protocols will be presented to illustrate the steps taken and the reasons behind their adoption. (author)
Lee, Cheng-Ling; Lee, Ray-Kuang; Kao, Yee-Mou
2006-11-13
We present the synthesis of multi-channel fiber Bragg grating (MCFBG) filters for dense wavelength-division-multiplexing (DWDM) application by using a simple optimization approach based on a Lagrange multiplier optimization (LMO) method. We demonstrate for the first time that the LMO method can be used to constrain various parameters of the designed MCFBG filters for practical application demands and fabrication requirements. The designed filters have a number of merits, i.e., flat-top and low dispersion spectral response as well as single stage. Above all, the maximum amplitude of the index modulation profiles of the designed MCFBGs can be substantially reduced under the applied constrained condition. The simulation results demonstrate that the LMO algorithm can provide a potential alternative for complex fiber grating filter design problems.
Design and operation of nitrifying trickling filters in recirculating aquaculture: a review
Eding, E.H.; Kamstra, A.; Verreth, J.A.J.; Huisman, E.A.; Klapwijk, A.
2006-01-01
This review deals with the main mechanisms and parameters affecting design and performance of trickling filters in aquaculture. Relationships between nitrification rates and easily accessible process parameters, like bulk phase concentration of TAN, O2, organic matter (COD), nitrite, temperature,
Design and Fabrication of Tri-Stopband Bandstop Filters Using Cascaded and Multi-Armed Methods
Directory of Open Access Journals (Sweden)
A. Boutejdar
2017-10-01
Full Text Available In this paper, we proposed a compact C-open-loop ring resonator and its equivalent circuit. The second cascaded BSF are designed using this simple C-ring resonator. The double ring BPF consists of two cascaded C-ring resonators, which are placed on the RO4003 substrate, while the other triple BSF structure consists of tree cascaded C-ring resonators, which are connected with input and output through microstrip feed lines. The both filters are simulated, optimized and partially realized using MWR simulator and Anritsu E5072A vector network analyzer VNA. In order to reduce the size and to improve the filter characteristics, novel compact filter topologies are designed basing on the previous structures. The proposed multi-band bandstop filters consist of several open-loop ring resonators placed vertically overlapping (coupled multi-armed ring resonator. Using this idea, the filter topologies with design flexibility, close size and excellent results are reached. The novel compact multi-band bandstop filters produce several stopband along a frequency range from DC to 9 GHz, in which each separate band exhibits an acceptable and useful bandwidth. Each stopband has regenerated two reflexion zeros, what leads to a good sharpness factors in the transition domains. Good agreement between the experimental results, full-wave simulation has been achieved. This new filter idea can be very attractive for the nowadays multilayer and compact radio frequency integrated circuit design.
Designing metallic iron based water filters: Light from methylene blue discoloration.
Btatkeu-K, B D; Tchatchueng, J B; Noubactep, C; Caré, S
2016-01-15
Available water filtration systems containing metallic iron (Fe(0) filters) are pragmatically designed. There is a lack of sound design criteria to exploit the full potential of Fe(0) filters. A science-based design relies on valuable information on processes within a Fe(0) filter, including chemical reactions, hydrodynamics and their relation to the performance of the filter. The aim of this study was to establish a simple method to evaluate the initial performance of Fe(0) filters. The differential adsorptive affinity of methylene blue (MB) onto sand and iron oxide is exploited to characterize the evolution of a Fe(0)/sand system using the pure sand system as operational reference. Five systems were investigated for more than 70 days: pure sand, pure Fe(0), Fe(0)/sand, Fe(0)/pumice and Fe(0)/sand/pumice. Individual systems were characterized by the extent of changes in pH value, iron breakthrough, MB breakthrough and hydraulic conductivity. Results showed that for MB discoloration (i) pure sand was the most efficient system, (ii) hybrid systems were more sustainable than the pure Fe(0) system, and (iii) the pores of used pumice are poorly interconnected. Characterizing the initial reactivity of Fe(0) filters using MB discoloration has introduced a powerful tool for the exploration of various aspects of filter design. Copyright © 2015 Elsevier Ltd. All rights reserved.
Design of recursive digital filters having specified phase and magnitude characteristics
King, R. E.; Condon, G. W.
1972-01-01
A method for a computer-aided design of a class of optimum filters, having specifications in the frequency domain of both magnitude and phase, is described. The method, an extension to the work of Steiglitz, uses the Fletcher-Powell algorithm to minimize a weighted squared magnitude and phase criterion. Results using the algorithm for the design of filters having specified phase as well as specified magnitude and phase compromise are presented.
The BNCT project in the Czech Republic
International Nuclear Information System (INIS)
Burian, J.; Marek, M.; Rataj, J.; Honova, H.; Petruzelka, L.; Prokes, K.; Tovarys, F.; Dbaly, V.; Honzatko, J.; Tomandl, I.
2000-01-01
The start of clinical trials is expected before NCT Osaka 2000. The experiences from different part of project are presented. The BNCT facility at LVR-15 reactor of NRI consists of epithermal neutron beam with improved construction (6.98 x 10 8 /cm 2 s with acceptable background of fast neutrons and gammas) and irradiation and control rooms equipped by appropriate devices. Internationally-recognized software MacNCTPLAN is utilized for computational dosimetry and treatment planning. In the part of protocol the following parameters have been assessed: patient selection, BSH dosage, fractionation, starting dose, dose escalation steps. At the LVR-15, at horizontal channel, a prompt gamma ray analysis (PGRA) system has been developed and is operated for BNCT purposes. Some human blood samples were analyzed and compared with classical ICP method. During the process of licensing the experience was obtained, some notes are discussed in the paper. The first results were received for the study of biological effect of the LVR source for small animal model. (author)
Directory of Open Access Journals (Sweden)
B. Kuldeep
2015-06-01
Full Text Available Fractional calculus has recently been identified as a very important mathematical tool in the field of signal processing. Digital filters designed by fractional derivatives give more accurate frequency response in the prescribed frequency region. Digital filters are most important part of multi-rate filter bank systems. In this paper, an improved method based on fractional derivative constraints is presented for the design of two-channel quadrature mirror filter (QMF bank. The design problem is formulated as minimization of L2 error of filter bank transfer function in passband, stopband interval and at quadrature frequency, and then Lagrange multiplier method with fractional derivative constraints is applied to solve it. The proposed method is then successfully applied for the design of two-channel QMF bank with higher order filter taps. Performance of the QMF bank design is then examined through study of various parameters such as passband error, stopband error, transition band error, peak reconstruction error (PRE, stopband attenuation (As. It is found that, the good design can be obtained with the change of number and value of fractional derivative constraint coefficients.
Design of Seasonal Adjustment Filter Robust to Variations in the Seasonal Behaviour of Time Series
Directory of Open Access Journals (Sweden)
Martelotte Marcela Cohen
2017-03-01
Full Text Available Considering that many macroeconomic time series present changing seasonal behaviour, there is a need for filters that are robust to such changes. This article proposes a method to design seasonal filters that address this problem. The design was made in the frequency domain to estimate seasonal fluctuations that are spread around specific bands of frequencies. We assessed the generated filters by applying them to artificial data with known seasonal behaviour based on the ones of the real macroeconomic series, and we compared their performance with the one of X-13A-S. The results have shown that the designed filters have superior performance for series with pronounced moving seasonality, being a good alternative in these cases.
Grid Filter Design for a Multi-Megawatt Medium-Voltage Voltage Source Inverter
DEFF Research Database (Denmark)
Rockhill, A.A.; Liserre, Marco; Teodorescu, Remus
2011-01-01
constraints. To achieve this goal, new concepts such as virtual harmonic content and virtual filter losses are introduced. Moreover, a new passive damping technique that provides the necessary damping with low losses and very little degradation of the high-frequency attenuation is proposed.......This paper describes the design procedure and performance of an LCL grid filter for a medium-voltage neutral point clamped (NPC) converter to be adopted for a multimegawatt wind turbine. The unique filter design challenges in this application are driven by a combination of the medium voltage...... converter, a limited allowable switching frequency, component physical size and weight concerns, and the stringent limits for allowable injected current harmonics. Traditional design procedures of grid filters for lower power and higher switching frequency converters are not valid for a multi...
An optimized cosine-modulated nonuniform filter bank design for subband coding of ECG signal
Directory of Open Access Journals (Sweden)
A. Kumar
2015-07-01
Full Text Available A simple iterative technique for the design of nonuniform cosine modulated filter banks (CMFBS is presented in this paper. The proposed technique employs a single parameter for optimization. The nonuniform cosine modulated filter banks are derived by merging the adjacent filters of uniform cosine modulated filter banks. The prototype filter is designed with the aid of different adjustable window functions such as Kaiser, Cosh and Exponential, and by using the constrained equiripple finite impulse response (FIR digital filter design technique. In this method, either cut off frequency or passband edge frequency is varied in order to adjust the filter coefficients so that reconstruction error could be optimized/minimized to zero. Performance and effectiveness of the proposed method in terms of peak reconstruction error (PRE, aliasing distortion (AD, computational (CPU time, and number of iteration (NOI have been shown through the numerical examples and comparative studies. Finally, the technique is exploited for the subband coding of electrocardiogram (ECG and speech signals.
Interpolation Filter Design for Hearing-Aid Audio Class-D Output Stage Application
DEFF Research Database (Denmark)
Pracný, Peter; Bruun, Erik; Llimos Muntal, Pere
2012-01-01
is to compare this design to designs presented in other state-of-the-art works ranging from hi-fi audio to hearing-aids. By performing comparison, trends and tradeoffs in interpolation filter design are indentified and hearing-aid specifications are derived. The possibilities for hardware reduction...
Media filter drain : modified design evaluation and existing design longevity evaluation.
2014-02-01
The media filter drain (MFD), a stormwater water quality treatment best management practice, consists of media made up of : aggregate, perlite, gypsum and dolomite in a trench located along roadway shoulders with gravel and vegetative pre-filtering :...
Design of one-dimensional optical pulse-shaping filters by time-domain topology optimization
DEFF Research Database (Denmark)
Yang, Lirong; Lavrinenko, Andrei; Hvam, Jørn Märcher
2009-01-01
Time-domain topology optimization is used here to design optical pulse-shaping filters in Si/SiO2 thin-film systems. A novel envelope objective function as well as explicit penalization are used to adapt the optimization method to this unique class of design problems.......Time-domain topology optimization is used here to design optical pulse-shaping filters in Si/SiO2 thin-film systems. A novel envelope objective function as well as explicit penalization are used to adapt the optimization method to this unique class of design problems....
Passivity-based design of robust passive damping for LCL-filtered voltage source converters
DEFF Research Database (Denmark)
Wang, Xiongfei; Blaabjerg, Frede; Loh, Poh Chiang
2015-01-01
Passive damping is proven as a robust stabilizing technique for LCL-filtered voltage source converters. However, conventional design methods of passive dampers are based on the passive components only, while the inherent damping effect of time delay in the digital control system is overlooked....... In this paper, a frequency-domain passivity-based design approach is proposed, where the passive dampers are designed to eliminate the negative real part of the converter output admittance with closed-loop current control, rather than shaping the LCL-filter itself. Thus, the influence of time delay...... in the current control is included, which allows a relaxed design of the passive damper with the reduced power loss and improved stability robustness against grid parameters variations. Design procedures of two commonly used passive dampers with LCL-filtered VSCs are illustrated. Experimental results validate...
Reliability-Oriented Optimization of the LC Filter Design of a Buck DC-DC Converter
DEFF Research Database (Denmark)
Liu, Yi; Huang, Meng; Wang, Huai
2017-01-01
Lifetime is an important performance factor in the reliable operation of power converters. However, the state-of-the-art LC filter design of a buck DC-DC converter is limited to the specifications of voltage and current ripples and constrains in power density and cost without reliability...... considerations. This paper proposes a method to optimize the design of the LC filters from a reliability perspective, besides other considerations. An enhanced model is derived to quantify the lifetime of the capacitor in the filter considering the electro-thermal stress on it. Furthermore, the influence...... of different design aspects like the value of capacitance, the value of inductance, type of the capacitor have been discussed, focusing on their impacts on the key design objectives which are the cut-off frequency, lifetime and volume. Based on the analysis, an optimized design is proposed among different...
Hybrid method for designing digital FIR filters based on fractional derivative constraints.
Baderia, Kuldeep; Kumar, Anil; Kumar Singh, Girish
2015-09-01
In this manuscript, a hybrid approach based on Lagrange multiplier method and cuckoo search (CS) optimization technique is proposed for the design of linear phase finite impulse response (FIR) filters using fractional derivative constraints. In the proposed method, FIR filter is designed by optimizing the integral squares in passband and stopband from ideal response such that the fractional derivatives of designed filter response become zero at a given frequency point. Lagrange multiplier method is exploited for finding the optimized filter coefficients. Optimal value of fractional derivative constraints for optimized filter coefficients are determined by minimizing the objective function constructed using a sum of maximum passband ripple and maximum stopband ripple in frequency domain using CS algorithm. Performance of the proposed method is evaluated by passband error (ϕ(p)), stopband error (ϕ(s)), stopband attenuation (A(s)), maximum passband ripple (MPR), maximum stopband ripple (MSR) and CPU time. A comparative study of the performance of particle swarm optimization (PSO) and artificial bee colony (ABC) for designing FIR filters using the proposed method is also made. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.
A case of astrocytoma, 19 year history after BNCT
International Nuclear Information System (INIS)
Kamano, Shuji
2006-01-01
A 39-year-old man had received Boron Neutron Capture Therapy (BNCT) in 1987 for a Grade II Astrocytoma. He gradually exacerbated and received a second operation in 1994. The mass taken in the second operation is almost competent with radiation necrosis. Following that, he shows no signs of recurrence. Currently, he has returned to full time employment in physical labor. This case suggests effectiveness of BNCT for rather low-grade astrocytomas. (author)
On the Application of the Parks-McClellan Algorithm to the Design of Quadrature Demodulation Filters
National Research Council Canada - National Science Library
Inkol, R
1999-01-01
New results are presented concerning the use of the Parks-McClellan algorithm to design filters for digital quadrature demodulators based on quadrature mixing and lowpass filtering concepts. The use of a 4...
Efficient design of two-dimensional recursive digital filters. Final report
International Nuclear Information System (INIS)
Twogood, R.E.; Mitra, S.K.
1980-01-01
This report outlines the research progress during the period August 1978 to July 1979. This work can be divided into seven basic project areas. Project 1 deals with a comparative study of 2-D recursive and nonrecursive digital filters. The second project addresses a new design technique for 2-D half-plane recursive filters, and Projects 3 thru 5 deal with implementation issues. The sixth project presents our recent study of the applicability of array processors to 2-D digital signal processing. The final project involves our investigation into techniques for incorporating symmetry constraints on 2-D recursive filters in order to yield more efficient implementations
Recombination chambers for BNCT dosimetry
International Nuclear Information System (INIS)
Tulik, Piotr
2006-01-01
Parallel plate recombination ionization chambers are known as the detectors which can be used for determination of gamma and high-LET dose components and for characterization of radiation quality of mixed radiation fields. Specially designed chambers can operate correctly even at dose rates of therapeutic beams. In this work the investigations were extended to a set of cylindrical chambers including a TE chamber and three graphite chambers filled with different gases - CO 2 , N 2 and 10 BF 3 , in order to determine the thermal neutrons, 14 N capture, gamma, and fast neutron dose components. The separation of the dose components is based on differences of the shape of the saturation curve, in dependence on LET spectrum of the investigated radiation. The measurements using all the chambers and a parallel plate recombination chamber were performed in a reactor beam of NRI Rez (Czech Republic). The gamma component was determined with accuracy of about 5%, while the variations of its value could be monitored with accuracy of about 0.5%. Relative changes of the beam components could be detected with accuracy of about 5% using the parallel plate chamber. The use of the chambers filled with different gases considerably improved the resolution of the method. (author)
Improved Results on Fuzzy H∞ Filter Design for T-S Fuzzy Systems
Directory of Open Access Journals (Sweden)
Jiyao An
2010-01-01
Full Text Available The fuzzy H∞ filter design problem for T-S fuzzy systems with interval time-varying delay is investigated. The delay is considered as the time-varying delay being either differentiable uniformly bounded with delay derivative in bounded interval or fast varying (with no restrictions on the delay derivative. A novel Lyapunov-Krasovskii functional is employed and a tighter upper bound of its derivative is obtained. The resulting criterion thus has advantages over the existing ones since we estimate the upper bound of the derivative of Lyapunov-Krasovskii functional without ignoring some useful terms. A fuzzy H∞ filter is designed to ensure that the filter error system is asymptotically stable and has a prescribed H∞ performance level. An improved delay-derivative-dependent condition for the existence of such a filter is derived in the form of linear matrix inequalities (LMIs. Finally, numerical examples are given to show the effectiveness of the proposed method.
Reliable Finite Frequency Filter Design for Networked Control Systems with Sensor Faults
Ju, He-Hua; Long, Yue; Wang, Heng
2012-01-01
This paper is concerned with the reliable finite frequency filter design for networked control systems (NCSs) subject to quantization and data missing. Taking into account quantization, possible data missing and sensor stuck faults, NCSs are modeled in the framework of discrete time-delay switched systems, and the finite frequency l2 gain is adopted for the filter design of discrete time-delay switched systems, which is converted into a set of linear matrix inequality (LMI) conditions. By the virtues of the derived conditions, a procedure of reliable filter synthesis is presented. Further, the filter gains are characterized in terms of solutions to a convex optimization problem which can be solved by using the semi-definite programme method. Finally, an example is given to illustrate the effectiveness of the proposed method. PMID:22969382
Proposal of a calculation methodology for the preliminary design of a coalescing filter
International Nuclear Information System (INIS)
Gonzalez Dobrosky, Cintia
2015-01-01
Coalescing filters are described which are equipments for capture and recovery of mist most efficient, inexpensive and have fewer limitations of application. The operation, equations and ideal characteristics of filter media of these models are explained. A methodology for design and scale-up of this type of equipment for liquid recovery in gaseous currents is proposed from experimental tests, in order to guide the interested reader in its making. (author) [es
Filter Design and Performance Evaluation for Fingerprint Image Segmentation.
Directory of Open Access Journals (Sweden)
Duy Hoang Thai
Full Text Available Fingerprint recognition plays an important role in many commercial applications and is used by millions of people every day, e.g. for unlocking mobile phones. Fingerprint image segmentation is typically the first processing step of most fingerprint algorithms and it divides an image into foreground, the region of interest, and background. Two types of error can occur during this step which both have a negative impact on the recognition performance: 'true' foreground can be labeled as background and features like minutiae can be lost, or conversely 'true' background can be misclassified as foreground and spurious features can be introduced. The contribution of this paper is threefold: firstly, we propose a novel factorized directional bandpass (FDB segmentation method for texture extraction based on the directional Hilbert transform of a Butterworth bandpass (DHBB filter interwoven with soft-thresholding. Secondly, we provide a manually marked ground truth segmentation for 10560 images as an evaluation benchmark. Thirdly, we conduct a systematic performance comparison between the FDB method and four of the most often cited fingerprint segmentation algorithms showing that the FDB segmentation method clearly outperforms these four widely used methods. The benchmark and the implementation of the FDB method are made publicly available.
Filter Design and Performance Evaluation for Fingerprint Image Segmentation.
Thai, Duy Hoang; Huckemann, Stephan; Gottschlich, Carsten
2016-01-01
Fingerprint recognition plays an important role in many commercial applications and is used by millions of people every day, e.g. for unlocking mobile phones. Fingerprint image segmentation is typically the first processing step of most fingerprint algorithms and it divides an image into foreground, the region of interest, and background. Two types of error can occur during this step which both have a negative impact on the recognition performance: 'true' foreground can be labeled as background and features like minutiae can be lost, or conversely 'true' background can be misclassified as foreground and spurious features can be introduced. The contribution of this paper is threefold: firstly, we propose a novel factorized directional bandpass (FDB) segmentation method for texture extraction based on the directional Hilbert transform of a Butterworth bandpass (DHBB) filter interwoven with soft-thresholding. Secondly, we provide a manually marked ground truth segmentation for 10560 images as an evaluation benchmark. Thirdly, we conduct a systematic performance comparison between the FDB method and four of the most often cited fingerprint segmentation algorithms showing that the FDB segmentation method clearly outperforms these four widely used methods. The benchmark and the implementation of the FDB method are made publicly available.
An Enhanced Non-Coherent Pre-Filter Design for Tracking Error Estimation in GNSS Receivers.
Luo, Zhibin; Ding, Jicheng; Zhao, Lin; Wu, Mouyan
2017-11-18
Tracking error estimation is of great importance in global navigation satellite system (GNSS) receivers. Any inaccurate estimation for tracking error will decrease the signal tracking ability of signal tracking loops and the accuracies of position fixing, velocity determination, and timing. Tracking error estimation can be done by traditional discriminator, or Kalman filter-based pre-filter. The pre-filter can be divided into two categories: coherent and non-coherent. This paper focuses on the performance improvements of non-coherent pre-filter. Firstly, the signal characteristics of coherent and non-coherent integration-which are the basis of tracking error estimation-are analyzed in detail. After that, the probability distribution of estimation noise of four-quadrant arctangent (ATAN2) discriminator is derived according to the mathematical model of coherent integration. Secondly, the statistical property of observation noise of non-coherent pre-filter is studied through Monte Carlo simulation to set the observation noise variance matrix correctly. Thirdly, a simple fault detection and exclusion (FDE) structure is introduced to the non-coherent pre-filter design, and thus its effective working range for carrier phase error estimation extends from (-0.25 cycle, 0.25 cycle) to (-0.5 cycle, 0.5 cycle). Finally, the estimation accuracies of discriminator, coherent pre-filter, and the enhanced non-coherent pre-filter are evaluated comprehensively through the carefully designed experiment scenario. The pre-filter outperforms traditional discriminator in estimation accuracy. In a highly dynamic scenario, the enhanced non-coherent pre-filter provides accuracy improvements of 41.6%, 46.4%, and 50.36% for carrier phase error, carrier frequency error, and code phase error estimation, respectively, when compared with coherent pre-filter. The enhanced non-coherent pre-filter outperforms the coherent pre-filter in code phase error estimation when carrier-to-noise density ratio
An Improved Variable Structure Adaptive Filter Design and Analysis for Acoustic Echo Cancellation
Directory of Open Access Journals (Sweden)
A. Kar
2015-04-01
Full Text Available In this research an advance variable structure adaptive Multiple Sub-Filters (MSF based algorithm for single channel Acoustic Echo Cancellation (AEC is proposed and analyzed. This work suggests a new and improved direction to find the optimum tap-length of adaptive filter employed for AEC. The structure adaptation, supported by a tap-length based weight update approach helps the designed echo canceller to maintain a trade-off between the Mean Square Error (MSE and time taken to attain the steady state MSE. The work done in this paper focuses on replacing the fixed length sub-filters in existing MSF based AEC algorithms which brings refinements in terms of convergence, steady state error and tracking over the single long filter, different error and common error algorithms. A dynamic structure selective coefficient update approach to reduce the structural and computational cost of adaptive design is discussed in context with the proposed algorithm. Simulated results reveal a comparative performance analysis over proposed variable structure multiple sub-filters designs and existing fixed tap-length sub-filters based acoustic echo cancellers.
Reliability-Oriented Design of LC Filter in Buck DC-DC Converter
DEFF Research Database (Denmark)
Liu, Yi; Huang, Meng; Wang, Huai
2015-01-01
State-of-the-art LC filter design of buck DC-DC converter is based on the specifications of voltage and current ripples and constrains in power density and cost. Since lifetime is an important performance factor in reliability critical applications, this digest proposes a method to optimize...... the design of the LC filters from a reliability perspective, among other considerations. It investigates the design freedom between the values of inductor and capacitors, the physical formation of the LC network, and the corresponding electro-thermal stresses of the selected capacitors. The outcome enables...... an optimized LC filter design to fulfill the required lifetime. The theoretical analysis and simulation study are presented which are verified by the experimental results from a buck converter prototype....
Design of FIR Filters with Discrete Coefficients using Ant Colony Optimization
Tsutsumi, Shuntaro; Suyama, Kenji
In this paper, we propose a new design method for linear phase FIR (Finite Impulse Response) filters with discrete coefficients. In a hardware implementation, filter coefficients must be represented as discrete values. The design problem of digital filters with discrete coefficients is formulated as the integer programming problem. Then, an enormous amount of computational time is required to solve the problem in a strict solver. Recently, ACO (Ant Colony Optimization) which is one heuristic approach, is used widely for solving combinational problem like the traveling salesman problem. In our method, we formulate the design problem as the 0-1 integer programming problem and solve it by using the ACO. Several design examples are shown to present effectiveness of the proposed method.
Energy Technology Data Exchange (ETDEWEB)
Bergman, W.; First, M.W.; Anderson, W.L. [Lawrence Livermore National Laboratory, CA (United States)] [and others
1995-02-01
We have reviewed the literature on the performance of HEPA filters under normal and abnormal conditions to establish criteria for calculating the efficiency of HEPA filters in a DOE nonreactor nuclear facility during and after a Design Basis Accident (DBA). This study is only applicable to the standard deep-pleated HEPA filter with aluminum separators as specified in ASME N509[1]. Other HEPA filter designs such as the mini-pleat and separatorless filters are not included in this study. The literature review included the performance of new filters and parameters that may cause deterioration in the filter performance such as filter age, radiation, corrosive chemicals, seismic and rough handling, high temperature, moisture, particle clogging, high air flow and pressure pulses. The deterioration of the filter efficiency depends on the exposure parameters; in severe exposure conditions the filter will be damaged and have a residual efficiency of 0%. There are large gaps and limitations in the data that introduce significant error in the estimates of HEPA filter efficiencies under DBA conditions. Because of this limitation, conservative values of filter efficiency were chosen. The estimation of the efficiency of the HEPA filters under DBA conditions involves three steps: (1) The filter pressure drop and environmental parameters are determined during and after the DBA, (2) Comparing the filter pressure drop to a set of threshold values above which the filter is damaged. There is a different threshold value for each combination of environmental parameters, and (3) Determining the filter efficiency. If the filter pressure drop is greater than the threshold value, the filter is damaged and is assigned 0% efficiency. If the pressure drop is less, then the filter is not damaged and the efficiency is determined from literature values of the efficiency at the environmental conditions.
International Nuclear Information System (INIS)
Bergman, W.; First, M.W.; Anderson, W.L.
1995-01-01
We have reviewed the literature on the performance of HEPA filters under normal and abnormal conditions to establish criteria for calculating the efficiency of HEPA filters in a DOE nonreactor nuclear facility during and after a Design Basis Accident (DBA). This study is only applicable to the standard deep-pleated HEPA filter with aluminum separators as specified in ASME N509[1]. Other HEPA filter designs such as the mini-pleat and separatorless filters are not included in this study. The literature review included the performance of new filters and parameters that may cause deterioration in the filter performance such as filter age, radiation, corrosive chemicals, seismic and rough handling, high temperature, moisture, particle clogging, high air flow and pressure pulses. The deterioration of the filter efficiency depends on the exposure parameters; in severe exposure conditions the filter will be damaged and have a residual efficiency of 0%. There are large gaps and limitations in the data that introduce significant error in the estimates of HEPA filter efficiencies under DBA conditions. Because of this limitation, conservative values of filter efficiency were chosen. The estimation of the efficiency of the HEPA filters under DBA conditions involves three steps: (1) The filter pressure drop and environmental parameters are determined during and after the DBA, (2) Comparing the filter pressure drop to a set of threshold values above which the filter is damaged. There is a different threshold value for each combination of environmental parameters, and (3) Determining the filter efficiency. If the filter pressure drop is greater than the threshold value, the filter is damaged and is assigned 0% efficiency. If the pressure drop is less, then the filter is not damaged and the efficiency is determined from literature values of the efficiency at the environmental conditions
Design and analysis of planar printed microwave and PBG filters using an FDTD method
DEFF Research Database (Denmark)
Tong, M.S.; Lu, Y.L.; Chen, Y.C.
2004-01-01
In this paper, various planar printed microwave and photonic band-gap (PBG) filters have been designed and analyzed by applying the finite difference time domain method, together with an unsplit-anisotropic perfectly matched layer technique as treatments of boundary conditions. The implemented...... solver was first validated by comparing the computed data with those published in literature, and a good agreement was observed between the results. Then, based on the specified design criteria, various microwave and PBG filters were designed and analyzed, in which the theoretical predictions matched...
The design, simulation, and fabrication of a BiCMOS VLSI digitally programmable GIC filter
Milne, Paul R.
2001-01-01
This thesis used a previously-designed programmable GIC filter as a basis in which to incorporate a BiCMOS operational amplifier. An NPN bipolar transistor layout was designed and incorporated into an opamp layout, which was a modified version of a CMOS-only design. The BiCMOS opamp was simulated using Silvaco SmartSpice and showed considerable improvement over its CMOS equivalent. Additional improvements were made to the GIC filter to include a passgate with reduced resistance, and a correct...
Optimal design of a bank of spatio-temporal filters for EEG signal classification.
Higashi, Hiroshi; Tanaka, Toshihisa
2011-01-01
The spatial weights for electrodes called common spatial pattern (CSP) are known to be effective in EEG signal classification for motor imagery based brain computer interfaces (MI-BCI). To achieve accurate classification in CSP, the frequency filter should be properly designed. To this end, several methods for designing the filter have been proposed. However, the existing methods cannot consider plural brain activities described with different frequency bands and different spatial patterns such as activities of mu and beta rhythms. In order to efficiently extract these brain activities, we propose a method to design plural filters and spatial weights which extract desired brain activity. The proposed method designs finite impulse response (FIR) filters and the associated spatial weights by optimization of an objective function which is a natural extension of CSP. Moreover, we show by a classification experiment that the bank of FIR filters which are designed by introducing an orthogonality into the objective function can extract good discriminative features. Moreover, the experiment result suggests that the proposed method can automatically detect and extract brain activities related to motor imagery.
Design and Implementation of Decimation Filter for 13-bit Sigma-Delta ADC Based on FPGA
Directory of Open Access Journals (Sweden)
Khalid Khaleel Mohammed
2016-10-01
Full Text Available A 13 bit Sigma-Delta ADC for a signal band of 40K Hz is designed in MATLAB Simulink and then implemented using Xilinx system generator tool. The first order Sigma-Delta modulator is designed to work at a signal band of 40 KHz at an oversampling ratio (OSR of 256 with a sampling frequency of 20.48 MHz. The proposed decimation filter design is consists of a second order Cascaded Integrator Comb filter (CIC followed by two finite impulse response (FIR filters. This architecture reduces the need for multiplication which is need very large area. This architecture implements a decimation ratio of 256 and allows a maximum resolution of 13 bits in the output of the filter. The decimation filter was designed and tested in Xilinx system generator tool which reduces the design cycle by directly generating efficient VHDL code. The results obtained show that the overall Sigma-Delta ADC is able to achieve an ENOB (Effective Number Of Bit of 13.71 bits and SNR of 84.3 dB
Houts, R. C.; Vaughn, G. L.
1974-01-01
Three algorithms are developed for designing finite impulse response digital filters to be used for pulse shaping and channel equalization. The first is the Minimax algorithm which uses linear programming to design a frequency-sampling filter with a pulse shape that approximates the specification in a minimax sense. Design examples are included which accurately approximate a specified impulse response with a maximum error of 0.03 using only six resonators. The second algorithm is an extension of the Minimax algorithm to design preset equalizers for channels with known impulse responses. Both transversal and frequency-sampling equalizer structures are designed to produce a minimax approximation of a specified channel output waveform. Examples of these designs are compared as to the accuracy of the approximation, the resultant intersymbol interference (ISI), and the required transmitted energy. While the transversal designs are slightly more accurate, the frequency-sampling designs using six resonators have smaller ISI and energy values.
A Novel Approach to the Design of Oversampling Low-Delay Complex-Modulated Filter Bank Pairs
Directory of Open Access Journals (Sweden)
Daniel Alfsmann
2009-01-01
Full Text Available In this contribution we present a method to design prototype filters of oversampling uniform complex-modulated FIR filter bank pairs. Especially, we present a noniterative two-step procedure: (i design of analysis prototype filter with minimum group delay and approximately linear-phase frequency response in the passband and the transition band and (ii Design of synthesis prototype filter such that the filter bank pairs distortion function approximates a linear-phase allpass function. Both aliasing and imaging are controlled by introducing sophisticated stopband constraints in both steps. Moreover, we investigate the delay properties of oversampling uniform complex-modulated FIR filter bank pairs in order to achieve the lowest possible filter bank delay. An illustrative design example demonstrates the potential of the design approach.
Comani, S.; Mantini, D.; Alleva, G.; Di Luzio, S.; Romani, G. L.
2005-12-01
The greatest impediment to extracting high-quality fetal signals from fetal magnetocardiography (fMCG) is environmental magnetic noise, which may have peak-to-peak intensity comparable to fetal QRS amplitude. Being an unstructured Gaussian signal with large disturbances at specific frequencies, ambient field noise can be reduced with hardware-based approaches and/or with software algorithms that digitally filter magnetocardiographic recordings. At present, no systematic evaluation of filters' performances on shielded and unshielded fMCG is available. We designed high-pass and low-pass Chebychev II-type filters with zero-phase and stable impulse response; the most commonly used band-pass filters were implemented combining high-pass and low-pass filters. The achieved ambient noise reduction in shielded and unshielded recordings was quantified, and the corresponding signal-to-noise ratio (SNR) and signal-to-distortion ratio (SDR) of the retrieved fetal signals was evaluated. The study regarded 66 fMCG datasets at different gestational ages (22-37 weeks). Since the spectral structures of shielded and unshielded magnetic noise were very similar, we concluded that the same filter setting might be applied to both conditions. Band-pass filters (1.0-100 Hz) and (2.0-100 Hz) provided the best combinations of fetal signal detection rates, SNR and SDR; however, the former should be preferred in the case of arrhythmic fetuses, which might present spectral components below 2 Hz.
International Nuclear Information System (INIS)
Comani, S; Mantini, D; Alleva, G; Luzio, S Di; Romani, G L
2005-01-01
The greatest impediment to extracting high-quality fetal signals from fetal magnetocardiography (fMCG) is environmental magnetic noise, which may have peak-to-peak intensity comparable to fetal QRS amplitude. Being an unstructured Gaussian signal with large disturbances at specific frequencies, ambient field noise can be reduced with hardware-based approaches and/or with software algorithms that digitally filter magnetocardiographic recordings. At present, no systematic evaluation of filters' performances on shielded and unshielded fMCG is available. We designed high-pass and low-pass Chebychev II-type filters with zero-phase and stable impulse response; the most commonly used band-pass filters were implemented combining high-pass and low-pass filters. The achieved ambient noise reduction in shielded and unshielded recordings was quantified, and the corresponding signal-to-noise ratio (SNR) and signal-to-distortion ratio (SDR) of the retrieved fetal signals was evaluated. The study regarded 66 fMCG datasets at different gestational ages (22-37 weeks). Since the spectral structures of shielded and unshielded magnetic noise were very similar, we concluded that the same filter setting might be applied to both conditions. Band-pass filters (1.0-100 Hz) and (2.0-100 Hz) provided the best combinations of fetal signal detection rates, SNR and SDR; however, the former should be preferred in the case of arrhythmic fetuses, which might present spectral components below 2 Hz
Energy Technology Data Exchange (ETDEWEB)
Hernandes, Antonio Carlos
2002-07-01
Boron Neutron Capture Therapy - BNCT- is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an AmBe neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these BNCT studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluency {Nu}{sub {Tau}} = 1,35x10{sup 8} n/cm{sup 2}, a fast neutron dose of 5,86x{sup -1}0 Gy/{Nu}{sub {Tau}} and a gamma ray dose of 8,30x{sup -14} Gy/{Nu}{sub {Tau}}. (author)
Nagare, Mukund B; Patil, Bhushan D; Holambe, Raghunath S
2017-02-01
B-Mode ultrasound images are degraded by inherent noise called Speckle, which creates a considerable impact on image quality. This noise reduces the accuracy of image analysis and interpretation. Therefore, reduction of speckle noise is an essential task which improves the accuracy of the clinical diagnostics. In this paper, a Multi-directional perfect-reconstruction (PR) filter bank is proposed based on 2-D eigenfilter approach. The proposed method used for the design of two-dimensional (2-D) two-channel linear-phase FIR perfect-reconstruction filter bank. In this method, the fan shaped, diamond shaped and checkerboard shaped filters are designed. The quadratic measure of the error function between the passband and stopband of the filter has been used an objective function. First, the low-pass analysis filter is designed and then the PR condition has been expressed as a set of linear constraints on the corresponding synthesis low-pass filter. Subsequently, the corresponding synthesis filter is designed using the eigenfilter design method with linear constraints. The newly designed 2-D filters are used in translation invariant pyramidal directional filter bank (TIPDFB) for reduction of speckle noise in ultrasound images. The proposed 2-D filters give better symmetry, regularity and frequency selectivity of the filters in comparison to existing design methods. The proposed method is validated on synthetic and real ultrasound data which ensures improvement in the quality of ultrasound images and efficiently suppresses the speckle noise compared to existing methods.
Enhanced Internet firewall design using stateful filters final report
Energy Technology Data Exchange (ETDEWEB)
Hutchins, J.A. [Sandia National Labs., Livermore, CA (United States). Infrastructure and Networking Research Dept.; Simons, R.W. [Sandia National Labs., Albuquerque, NM (United States). Decision Support Systems Architectures
1997-08-01
The current state-of-the-art in firewall design provides a lot of security for company networks, but normally at the expense of performance and/or functionality. Sandia researched a new approach to firewall design which incorporates a highly stateful approach, allowing much more flexibility for protocol checking and manipulation while retaining performance. A prototype system was built and multiple protocol policy modules implemented to test the concept. The resulting system, though implemented on a low-power workstation, performed almost at the same performance as Sandia`s current firewall.
Design, Fabrication and Installation of the Charcoal Filter Housing in RIPF
Energy Technology Data Exchange (ETDEWEB)
Kim, Min Jin; Lim, I. C.; Bang, H. S. (and others)
2008-05-15
In the Hot Cell Bank 3 of the Radioisotope Production Facility, production and dispense of I-131 solution and capsule that are used for the diagnosis and treatment of thyroid cancer are made. The original charcoal filter housings installed in 1994 and were utilized until the leakage of a very small amount of radio-iodine was found due to the erroneous installation of the charcoal filter in the filter housing. Thus the production of I-131 was discontinued until the repair and performance testing of the filter housing and the inspection by the regulatory body were finished. Although the production of I-131 was resumed, there was a desire for installing the brand-new charcoal filter housing which has an intrinsically safe design and no possibility of leakage. This report describes the design, fabrication and installation of brand-new charcoal filter housing. And also were described the dismantlement of the old housings, the assessment of the structural integrity of the shielding concrete wall and the installation of the shielding doors.
Kilbourne, Caroline A.; Adams, Joseph S.; Arsenovic, Petar; Ayers, Travis; Chiao, Meng P.; Dipirro, Michael J.; Eckart, Megan E.; Fujimoto, Ryuichi; Kazeva, John D.; Kelley, Richard L.; Kripps, Kari L.; Lairson, Bruce; Leutenegger, Maurice A.; Lopez, Heidi; McCammon, Dan; McGuinness, Daniel S.; Mitsuda, Kazuhisa; Moseley, Samuel J.; Porter, F. S.; Schweiss, Andrea N.; Takei, Yoh; Thorpe, Rosemary S.; Watanabe, Tomomi; Yamasaki, Noriko Y.; Yoshida, Seiji
2016-07-01
The calorimeter array of the JAXA Astro-H (renamed Hitomi) Soft X-ray Spectrometer (SXS) was designed to provide unprecedented spectral resolution of spatially extended cosmic x-ray sources and of all cosmic x-ray sources in the Fe-K band around 6 keV, enabling essential plasma diagnostics. The properties that make the SXS array a powerful x-ray spectrometer also make it sensitive to photons from the entire electromagnetic band, and particles as well. If characterized as a bolometer, it would have a noise equivalent power (NEP) of filters, anchored to the nested temperature stages, that block long-wavelength radiation while minimizing x-ray attenuation. The aperture assembly is a system of barriers, baffles, filter carriers, and filter mounts that supports the filters and inhibits their potential contamination. The three outer filters also have been equipped with thermometers and heaters for decontamination. We present the requirements, design, implementation, and performance of the SXS aperture assembly and blocking filters.
Electromagnetic design methods in systems-on-chip: integrated filters for wireless CMOS RFICs
International Nuclear Information System (INIS)
Contopanagos, Harry
2005-01-01
We present general methods for designing on-chip CMOS passives and utilizing these integrated elements to design on-chip CMOS filters for wireless communications. These methods rely on full-wave electromagnetic numerical calculations that capture all the physics of the underlying foundry technologies. This is especially crucial for deep sub-micron CMOS technologies as it is important to capture the physical effects of finite (and mediocre) Q-factors limited by material losses and constraints on expensive die area, low self-resonance frequencies and dual parasitics that are particularly prevalent in deep sub-micron CMOS processes (65 nm-0.18 μm. We use these integrated elements in an ideal synthesis of a Bluetooth/WLAN pass-band filter in single-ended or differential architectures, and show the significant deviations of the on-chip filter response from the ideal one. We identify which elements in the filter circuit need to maximize their Q-factors and which Q-factors do not affect the filter performance. This saves die area, and predicts the FET parameters (especially transconductances) and negative-resistance FET topologies that have to be integrated in the filter to restore its performance. (invited paper)
Directory of Open Access Journals (Sweden)
I. Sharma
2016-09-01
Full Text Available In this paper, a linear phase FIR filter is designed through recently proposed nature inspired optimization algorithm known as Cuckoo search (CS. A comparative study of Cuckoo search (CS, particle swarm optimization (PSO and artificial bee colony (ABC nature inspired optimization methods in the field of linear phase FIR filter design is also presented. For this purpose, an improved L1 weighted error function is formulated in frequency domain, and minimized through CS, PSO and ABC respectively. The error or objective function has a controlling parameter wt which controls the amount of ripple in the desired band of frequency. The performance of FIR filter is examined through three key parameters; Maximum Pass Band Ripple (MPR, Maximum Stopband Ripple (MSR and Stopband Attenuation (As. Comparative study and the simulation results reveal that the designed filter with CS gives better performance in terms of Maximum Stopband Ripple (MSR, and Stopband Attenuation (As for low order filter design, and for higher order it also gives better performance in term of Maximum Passband Ripple (MPR. Superiority of the proposed technique is also shown through comparison with other recently proposed methods.
Design optimisation of powers-of-two FIR filter using self-organising random immigrants GA
Chandra, Abhijit; Chattopadhyay, Sudipta
2015-01-01
In this communication, we propose a novel design strategy of multiplier-less low-pass finite impulse response (FIR) filter with the aid of a recent evolutionary optimisation technique, known as the self-organising random immigrants genetic algorithm. Individual impulse response coefficients of the proposed filter have been encoded as sum of signed powers-of-two. During the formulation of the cost function for the optimisation algorithm, both the frequency response characteristic and the hardware cost of the discrete coefficient FIR filter have been considered. The role of crossover probability of the optimisation technique has been evaluated on the overall performance of the proposed strategy. For this purpose, the convergence characteristic of the optimisation technique has been included in the simulation results. In our analysis, two design examples of different specifications have been taken into account. In order to substantiate the efficiency of our proposed structure, a number of state-of-the-art design strategies of multiplier-less FIR filter have also been included in this article for the purpose of comparison. Critical analysis of the result unambiguously establishes the usefulness of our proposed approach for the hardware efficient design of digital filter.
Directory of Open Access Journals (Sweden)
Homayoon Oraizi
2012-01-01
Full Text Available Optimum design of a novel ultra-wideband multilayer microstrip hairpin filter is presented, providing for harmonic suppression and impedance matching between source and load impedances. The theory of N-coupled transmission lines is employed to obtain an equivalent circuit for development of a design procedure based on the method of least squares. A prototype model of proposed two-layer filter of order 5 is fabricated for 3.1–10.6 GHz. The dimensions of designed filter are 23 mm × 7 mm. The insertion loss in the passband varies from 0.3 dB to 3 dB (in the worst case at the edge of passband and in the stopband is about 30 dB up to 20 GHz. Its group delay in the UWB region is about 0.5 ns. Close agreement among the filter frequency responses as obtained by the proposed method, full-wave computer simulation softwares, and measurement data verify the effectiveness of the proposed filter structure and design methods.
Spatial filter lens design for the main laser of the National Ignition Facility
International Nuclear Information System (INIS)
Korniski, R.J.
1998-01-01
The National Ignition Facility (NIF), being designed and constructed at Lawrence Livermore National Laboratory (LLNL), comprises 192 laser beams The lasing medium is neodymium in phosphate glass with a fundamental frequency (1ω) of 1 053microm Sum frequency generation in a pair of conversion crystals (KDP/KD*P) will produce 1 8 megajoules of the third harmonic light (3ω or λ=351microm) at the target The purpose of this paper is to provide the lens design community with the current lens design details of the large optics in the Main Laser This paper describes the lens design configuration and design considerations of the Main Laser The Main Laser is 123 meters long and includes two spatial filters one 13 5 meters and one 60 meters These spatial filters perform crucial beam filtering and relaying functions We shall describe the significant lens design aspects of these spatial filter lenses which allow them to successfully deliver the appropriate beam characteristic onto the target For an overview of NIF please see ''Optical system design of the National Ignition Facility,'' by R Edward English. et al also found in this volume
Joint Linear Filter Design in Multiuser Cooperative Nonregenerative MIMO Relay Systems
Directory of Open Access Journals (Sweden)
Gen Li
2009-01-01
Full Text Available This paper addresses the filter design issues for multiuser cooperative nonregenerative MIMO relay systems in both downlink and uplink scenarios. Based on the formulated signal model, the filter matrix optimization is first performed for direct path and relay path respectively, aiming to minimize the mean squared error (MSE. To be more specific, for the relay path, we derive the local optimal filter scheme at the base station and the relay station jointly in the downlink scenario along with a more practical suboptimal scheme, and then a closed-form joint local optimal solution in the uplink scenario is exploited. Furthermore, the optimal filter for the direct path is also presented by using the exiting results of conventional MIMO link. After that, several schemes are proposed for cooperative scenario to combine the signals from both paths. Numerical results show that the proposed schemes can reduce the bit error rate (BER significantly.
DEFF Research Database (Denmark)
Christensen, Kim Müller; Pedersen, Michael Jønch; Dam-Johansen, Kim
2012-01-01
-batch operation, are reduced impurity formation and the use of much lower reactor volumes (factor of 1000 based on the laboratory reactor) and less solvent consumption (from 5.8 to 2.3L/kg reactant). Added challenges include handling of continuous solid powder feeding, stable pumping of reactive slurries......A novel filter reactor system for continuous production of selected pharmaceutical intermediates is presented and experimentally verified. The filter reactor system consists of a mixed flow reactor equipped with a bottom filter, to retain solid reactant particles, followed by a conventional plug...... in tetrahydrofuran solvent. The use of the filter reactor design was explored by examining the transferability of a synthesis step in a present full-scale semi-batch pharmaceutical production into continuous processing. The main advantages of the new continuous minireactor system, compared to the conventional semi...
Cuevas, Andres; Diaz-Ramirez, Victor H.; Kober, Vitaly; Trujillo, Leonardo
2014-09-01
Facial recognition is a difficult task due to variations in pose and facial expressions, as well as presence of noise and clutter in captured face images. In this work, we address facial recognition by means of composite correlation filters designed with multi-objective combinatorial optimization. Given a large set of available face images having variations in pose, gesticulations, and global illumination, a proposed algorithm synthesizes composite correlation filters by optimization of several performance criteria. The resultant filters are able to reliably detect and correctly classify face images of different subjects even when they are corrupted with additive noise and nonhomogeneous illumination. Computer simulation results obtained with the proposed approach are presented and discussed in terms of efficiency in face detection and reliability of facial classification. These results are also compared with those obtained with existing composite filters.
Broadband notch filter design for millimeter-wave plasma diagnostics
DEFF Research Database (Denmark)
Furtula, Vedran; Michelsen, Poul; Leipold, Frank
2010-01-01
of ±9 GHz. The design is based on a fundamental rectangular waveguide with eight cylindrical cavities coupled by T-junction apertures formed as thin slits. Parameters that affect the notch performance such as physical lengths and conductor materials are discussed. The excited resonance mode...
Directory of Open Access Journals (Sweden)
Jesús García Herrero
2003-07-01
Full Text Available This paper describes the application of evolution strategies to the design of interacting multiple model (IMM tracking filters in order to fulfill a large table of performance specifications. These specifications define the desired filter performance in a thorough set of selected test scenarios, for different figures of merit and input conditions, imposing hundreds of performance goals. The design problem is stated as a numeric search in the filter parameters space to attain all specifications or at least minimize, in a compromise, the excess over some specifications as much as possible, applying global optimization techniques coming from evolutionary computation field. Besides, a new methodology is proposed to integrate specifications in a fitness function able to effectively guide the search to suitable solutions. The method has been applied to the design of an IMM tracker for a real-world civil air traffic control application: the accomplishment of specifications defined for the future European ARTAS system.
Directory of Open Access Journals (Sweden)
N. A. Shah
2011-01-01
Full Text Available A generic design (GD for realizing an nth order log-domain multifunction filter (MFF, which can yield four possible stable filter configurations, each offering simultaneously lowpass (LP, highpass (HP, and bandpass (BP frequency responses, is presented. The features of these filters are very simple, consisting of merely a few exponential transconductor cells and capacitors; all grounded elements, capable of absorbing the shunt parasitic capacitances, responses are electronically tuneable, and suitable for monolithic integration. Furthermore, being designed using log-domain technique, it offers all its advantages. As an example, 5th-order MFFs are designed in each case and their performances are evaluated through simulation. Lastly, a comparative study of the MFFs is also carried, which helps in selecting better high-order MFF for a given application.
Design of adaptive filter amplifier in UV communication based on DSP
Lv, Zhaoshun; Wu, Hanping; Li, Junyu
2016-10-01
According to the problem of the weak signal at receiving end in UV communication, we design a high gain, continuously adjustable adaptive filter amplifier. Based on proposing overall technical indicators and analyzing its working principle of the signal amplifier, we use chip LMH6629MF and two chips of AD797BN to achieve three-level cascade amplification. And apply hardware of DSP TMS320VC5509A to implement digital filtering. Design and verification by Multisim, Protel 99SE and CCS, the results show that: the amplifier can realize continuously adjustable amplification from 1000 to 10000 times without distortion. Magnification error is <=%4@1000 10000. And equivalent input noise voltage of amplification circuit is <=6 nV/ √Hz @30KHz 45KHz, and realizing function of adaptive filtering. The design provides theoretical reference and technical support for the UV weak signal processing.
Robust Kalman filter design for predictive wind shear detection
Stratton, Alexander D.; Stengel, Robert F.
1991-01-01
Severe, low-altitude wind shear is a threat to aviation safety. Airborne sensors under development measure the radial component of wind along a line directly in front of an aircraft. In this paper, optimal estimation theory is used to define a detection algorithm to warn of hazardous wind shear from these sensors. To achieve robustness, a wind shear detection algorithm must distinguish threatening wind shear from less hazardous gustiness, despite variations in wind shear structure. This paper presents statistical analysis methods to refine wind shear detection algorithm robustness. Computational methods predict the ability to warn of severe wind shear and avoid false warning. Comparative capability of the detection algorithm as a function of its design parameters is determined, identifying designs that provide robust detection of severe wind shear.
Leviton, Douglas B.; Tsvetanov, Zlatan; Woodruff, Robert A.; Mooney, Thomas A.
1998-08-01
Advanced optical bandpass filters for the Hubble Space Telescope (HST) advanced camera for surveys (ACS) have been developed on a filer-by-filter basis through detailed studies which take into account the instrument's science goals, available optical filter fabrication technology, and developments in ACS's charge-coupled-device detector technology. These filters include a subset of filters for the Sloan Digital Sky Survey which are optimized for astronomical photometry using today's charge-coupled- devices. In order for ACS to be truly advanced, these filters must push the state-of-the-at in performance in a number of key areas at the same time. Important requirements for these filters include outstanding transmitted wavefront, high transmittance, uniform transmittance across each filter, spectrally structure-free bandpasses, exceptionally high out of band rejection, a high degree of parfocality, and immunity to environmental degradation. These constitute a very stringent set of requirements indeed, especially for filters which are up to 90 mm in diameter. The highly successful paradigm in which final specifications for flight filters were derived through interaction amongst the ACS Science Team, the instrument designer, the lead optical engineer, and the filter designer and vendor is described. Examples of iterative design trade studies carried out in the context of science needs and budgetary and schedule constraints are presented. An overview of the final design specifications for the ACS bandpass and ramp filters is also presented.
Design and Analysis of a Micromachined LC Low Pass Filter For 2.4GHz Application
Saroj, Samruddhi R.; Rathee, Vishal R.; Pande, Rajesh S.
2018-02-01
This paper reports design and analysis of a passive low pass filter with cut-off frequency of 2.4 GHz using MEMS (Micro Electro-Mechanical Systems) technology. The passive components such as suspended spiral inductors and metal-insulator-metal (MIM) capacitor are arranged in T network form to implement LC low pass filter design. This design employs a simple approach of suspension thereby reducing parasitic losses to eliminate the performance degrading effects caused by integrating an off-chip inductor in the filter circuit proposed to be developed on a low cost silicon substrate using RF-MEMS components. The filter occupies only 2.1 mm x 0.66 mm die area and is designed using micro-strip transmission line placed on a silicon substrate. The design is implemented in High Frequency Structural Simulator (HFSS) software and fabrication flow is proposed for its implementation. The simulated results show that the design has an insertion loss of -4.98 dB and return loss of -2.60dB.
Comparison and analysis of BNCT radiation dose between gold wire and JCDS measurement
International Nuclear Information System (INIS)
Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, Hiroaki
2006-01-01
We compared and evaluated boron neutron capture therapy (BNCT) radiation dose between gold wire measurement and JAERI Computational Dosimetry System (JCDS). Gold wire analysis demonstrates the actual BNCT dose though it dose not reflect the real the maximum and minimum dose in tumor tissue. We can conclude that JCDS is precise and high-reliable dose planning system for BNCT. (author)
Minimizing Design Costs of an FIR Filter Using a Novel Coefficient Optimization Algorithm
Directory of Open Access Journals (Sweden)
Ming-Chih Chen
2014-01-01
Full Text Available This work presents a novel coefficient optimization algorithm to reduce the area and improve the performance of finite impulse response (FIR filter designs. Two basic architectures are commonly used in filters—direct and transposed. The coefficients of a filter can be encoded in the fewest possible nonzero bits using canonic signed digit (CSD expressions. The proposed optimization algorithm can share common subexpressions (CS and reduce the number of replicate operations that involve the CSD coefficients of filters with a transposed architecture. The effectiveness of the algorithm is confirmed by using filters with the collision detection multiple access (CDMA standard, the 121-tap high-pass band, and 105- and 325-tap low-pass bands as benchmarks. For example, the proposed algorithm used in the optimization of 105-tap filter has a 30.44% smaller combinational logic area and a 16.69% better throughput/area than those of the best design that has been developed to date. Experimental results reveal that the proposed algorithm outperforms earlier designs.
Khodaee, M; Banakermani, M; Baghban, H
2015-10-10
Engineering metamaterial-based devices such as terahertz bandpass filters (BPFs) play a definitive role in advancement of terahertz technology. In this article, we propose a design procedure to obtain a considerably broadband terahertz BPF at a normal incidence; it shows promising filtering characteristics, including a wide passband of ∼1.34 THz at a central frequency of 1.17 THz, a flat top in a broad band, and high transmission, compared to previous reports. Then, exploiting the voltage-dependent carrier density control in an AlGaN/GaN heterostructure with a Schottky gate configuration, we investigate the tuning of the transmission properties in a narrow-band terahertz filter. A combination of the ultra-wide, flat-top BPF in series with the tunable, narrow band filter designed in the current study offers the ability to tune the desired resonance frequency along with high out-of-band rejection and the suppression of unwanted resonances in a large spectral range. The proposed structure exhibits a frequency tunability of 103 GHz for a voltage change between -8 and 2 V, and a transmission amplitude change of ∼0.51. This scheme may open up a route for the improved design of terahertz filters and modulators.
Radiation field characterization of a BNCT research facility using Monte Carlo method - code MCNP-4B
International Nuclear Information System (INIS)
Hernandez, Antonio Carlos
2002-01-01
Boron Neutron Capture Therapy - BNCT - is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an Am Be neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these Becton studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluencyN T = 1,35x10 8 n/cm , a fast neutron dose of 5,86x10 -10 Gy/N T and a gamma ray dose of 8,30x10 -14 Gy/N T . (author)
A filter-mediated communication model for design collaboration in building construction.
Lee, Jaewook; Jeong, Yongwook; Oh, Minho; Hong, Seung Wan
2014-01-01
Multidisciplinary collaboration is an important aspect of modern engineering activities, arising from the growing complexity of artifacts whose design and construction require knowledge and skills that exceed the capacities of any one professional. However, current collaboration in the architecture, engineering, and construction industries often fails due to lack of shared understanding between different participants and limitations of their supporting tools. To achieve a high level of shared understanding, this study proposes a filter-mediated communication model. In the proposed model, participants retain their own data in the form most appropriate for their needs with domain-specific filters that transform the neutral representations into semantically rich ones, as needed by the participants. Conversely, the filters can translate semantically rich, domain-specific data into a neutral representation that can be accessed by other domain-specific filters. To validate the feasibility of the proposed model, we computationally implement the filter mechanism and apply it to a hypothetical test case. The result acknowledges that the filter mechanism can let the participants know ahead of time what will be the implications of their proposed actions, as seen from other participants' points of view.
Phase Response Design of Recursive All-Pass Digital Filters Using a Modified PSO Algorithm.
Chang, Wei-Der
2015-01-01
This paper develops a new design scheme for the phase response of an all-pass recursive digital filter. A variant of particle swarm optimization (PSO) algorithm will be utilized for solving this kind of filter design problem. It is here called the modified PSO (MPSO) algorithm in which another adjusting factor is more introduced in the velocity updating formula of the algorithm in order to improve the searching ability. In the proposed method, all of the designed filter coefficients are firstly collected to be a parameter vector and this vector is regarded as a particle of the algorithm. The MPSO with a modified velocity formula will force all particles into moving toward the optimal or near optimal solution by minimizing some defined objective function of the optimization problem. To show the effectiveness of the proposed method, two different kinds of linear phase response design examples are illustrated and the general PSO algorithm is compared as well. The obtained results show that the MPSO is superior to the general PSO for the phase response design of digital recursive all-pass filter.
Low-Cost Design of an FIR Filter by Using a Coefficient Mapping Method
Directory of Open Access Journals (Sweden)
Ming-Chih Chen
2013-01-01
Full Text Available This work presents a novel coefficient mapping method to reduce the area cost of the finite impulse response (FIR filter design, especially for optimizing its coefficients. Being capable of reducing the area cost and improving the filter performance, the proposed mapping method consists of four steps: quantization of coefficients, import of parameters, constitution of prime coefficients with parameters, and constitution of residual coefficients with prime coefficients. Effectiveness of the proposed coefficient mapping method is verified by selecting the 48-tap filter of IS-95 code division multiple access (CDMA standard as the benchmark. Experimental results indicate that the proposed design with canonical signed digit (CSD coefficients can operate at 86 MHz with an area of 241,813 um2, leading to a throughput rate of 1,382 Mbps. Its ratio of throughput/area is 5,715 Kbps/um2, yielding a higher performance than that of previous designs. In summary, the proposed design reduces 5.7% of the total filter area, shortens 25.7% of the critical path delay, and improves 14.8% of the throughput/area by a value over that of the best design reported before.
Umeshkumar, Dubey Suhmita; Kumar, Manish
2018-04-01
This paper incorporates an improved design of Ultra Wideband Bandpass filter by using split ring resonators (SRR) along with the coupled microstrip lines. The use of split ring resonators and shunt step impedance open circuit stub enhances the stability due to transmission zeroes at the ends. The designing of filter and simulation of parameters is carried out using Ansoft's HFSS 13.0 software on RT/Duroid 6002 as a substrate with dielectric constant of 2.94. The design utilizes a frequency band from 22GHz to 29GHz. This band is reserved for Automotive Radar system and sensors as per FCC specifications. The proposed design demonstrates insertion loss less than 0.6dB and return loss better than 12dB at mid frequency i.e. 24.4GHz. The reflection coefficient shows high stability of about 12.47dB at mid frequency. The fractional bandwidth of the proposed filter is about 28.7% and size of filter design is small due to thickness of 0.127mm.
Wodecki, Jacek; Michalak, Anna; Zimroz, Radoslaw
2018-03-01
Harsh industrial conditions present in underground mining cause a lot of difficulties for local damage detection in heavy-duty machinery. For vibration signals one of the most intuitive approaches of obtaining signal with expected properties, such as clearly visible informative features, is prefiltration with appropriately prepared filter. Design of such filter is very broad field of research on its own. In this paper authors propose a novel approach to dedicated optimal filter design using progressive genetic algorithm. Presented method is fully data-driven and requires no prior knowledge of the signal. It has been tested against a set of real and simulated data. Effectiveness of operation has been proven for both healthy and damaged case. Termination criterion for evolution process was developed, and diagnostic decision making feature has been proposed for final result determinance.
Sequential filter design for precision orbit determination and physical constant refinement
Curkendall, D. W.; Leondes, C. T.
1974-01-01
Earth-based spacecraft tracking data have historically been processed with classical least squares filtering techniques both for navigation purposes and for physical constant determination. The small, stochastic nongravitational forces acting on the spacecraft are described to motivate the use of sequential estimation as an alternative to the least squares fitting procedures. The stochastic forces are investigated both in terms of their effect on the tracking data and their influence on estimation accuracy. A flexible sequential filter design which leaves the existing trajectory, variational equations, data observable and partial computations undisturbed is described. A detailed filter design is presented that meets the precision demands and flexibility requirements of deep space navigation and of scientific problems.
Ngo, Nam Quoc; Song, Yufeng; Lin, Bo
2011-02-01
We present the design and analysis of a wideband and tunable optical Hilbert transformer (OHT) using a tunable waveguide-based finite-impulse response (FIR) filter structure by using the digital filter design method and the Remez algorithm. The tunable Nth-order waveguide-based FIR filter, which simply consists of N delay lines, N tunable couplers, N tunable phase shifters and a combiner, can be tuned, by thermally adjusting the tunable couplers and tunable phase shifters, to tune the bandwidth of an OHT using silica-based planar lightwave circuit (PLC) technology. To demonstrate the effectiveness of the method, the simulation results have an excellent agreement with the theoretical predictions. The tunable OHT can function as a wideband and tunable 90° phase shifter and thus has many potential applications. The two unique features of wideband characteristic (up to ~ 2 THz) and tunable bandwidth (THz tuning range) of the proposed OHT cannot be obtained from the existing OHTs.
Design and realization of an all-fiber broadband tunable gain equalization filter for DWDM signals.
Varshney, R K; Nagaraju, B; Singh, A; Pal, B P; Kar, A K
2007-10-17
Design and fabrication of a tunable gain equalization filter for dense wavelength division multiplexed (DWDM) signals through erbium doped fiber amplifiers (EDFA) is reported. It is based on a side-polished fiber (SPF) half-coupler block loaded with a displaceable tapered multimode overlay waveguide (MMOW). A simple and accurate normal mode analysis is employed to design this filtering device for its subsequent realization. Equalization of a typical EDFA gain spectrum in the C-band within +/-0.35 dB or even less in the presence of various ITU standard C-band DWDM signal channels is demonstrated under varied operating conditions like add/drop of signals. Tunability of the filter notch is achieved through displacement of the SPF relative to the MMOW.
Parallel power electronics filters in three-phase four-wire systems principle, control and design
Wong, Man-Chung; Lam, Chi-Seng
2016-01-01
This book describes parallel power electronic filters for 3-phase 4-wire systems, focusing on the control, design and system operation. It presents the basics of power-electronics techniques applied in power systems as well as the advanced techniques in controlling, implementing and designing parallel power electronics converters. The power-quality compensation has been achieved using active filters and hybrid filters, and circuit models, control principles and operational practice problems have been verified by principle study, simulation and experimental results. The state-of-the-art research findings were mainly developed by a team at the University of Macau. Offering background information and related novel techniques, this book is a valuable resource for electrical engineers and researchers wanting to work on energy saving using power-quality compensators or renewable energy power electronics systems. .
Yousefinezhad, Sajad; Kermani, Saeed; Hosseinnia, Saeed
2018-01-01
The operational transconductance amplifier-capacitor (OTA-C) filter is one of the best structures for implementing continuous-time filters. It is particularly important to design a universal OTA-C filter capable of generating the desired filter response via a single structure, thus reducing the filter circuit power consumption as well as noise and the occupied space on the electronic chip. In this study, an inverter-based universal OTA-C filter with very low power consumption and acceptable noise was designed with applications in bioelectric and biomedical equipment for recording biomedical signals. The very low power consumption of the proposed filter was achieved through introducing bias in subthreshold MOSFET transistors. The proposed filter is also capable of simultaneously receiving favorable low-, band-, and high-pass filter responses. The performance of the proposed filter was simulated and analyzed via HSPICE software (level 49) and 180 nm complementary metal-oxide-semiconductor technology. The rate of power consumption and noise obtained from simulations are 7.1 nW and 10.18 nA, respectively, so this filter has reduced noise as well as power consumption. The proposed universal OTA-C filter was designed based on the minimum number of transconductance blocks and an inverter circuit by three transconductance blocks (OTA).
Modular filter design for the white-beam undulator/wiggler beamlines at the Advanced Photon Source
International Nuclear Information System (INIS)
Brite, C.; Shu, D.; Nian, T.; Wang, Z.; Haeffner, D.; Alp, E.; Kuzay, T.
1994-01-01
A new filter has been designed at Argonne National Laboratory that is intended for the use in undulator/wiggler beamlines at the Advanced Photon Source. The water-cooled frame allows up to four individual filter foil banks simultaneously in the beam path. Additionally, the bottom of each frame holds two thin (20 μm) uncooled carbon filters in tandem for low-energy filtering. Therefore, a maximum of 625 filter selection combinations is theoretically possible. The design is intelligent, compact and modular, with great flexibility for the users. To prevent accidental movement of the filter, effort has been taken to provide a mechanically locked, fail-safe actuator system. Programming aspects are under development as part of our general personnel and equipment protection system. Aspects of the design and operational principles of the filter are presented in this paper
The design of a 4’th order Bandpass Butterworth filter with one operational amplifier
DEFF Research Database (Denmark)
Gaunholt, Hans
2008-01-01
A numerical design method is presented for the design of all pole band pass active-RC filters applying just one operational amplifier. The operational amplifier model used is the integrator model: ωt/s where ωt is the unity gain fre-quency. The design method is used for the design of a fourth order...... band pass filter with Butterworth poles applying just one operational amplifier coupled as a unity gain amplifier. The unity gain amplifiers have the advantage of providing low power consumption, yielding a large dynamic range, sometimes simplifying the amplifier design and being usable over a larger...... frequency range than conventional constant gain amplifiers. The Schoeffler sensitivity index is used as a basis for a practical realization of the circuit....
Guan, Xingcai; Manabe, Masanobu; Tamaki, Shingo; Sato, Fuminobu; Murata, Isao; Wang, Tieshan
2017-07-01
The neutron flux monitors from 10keV to 1MeV designed for boron neutron capture therapy (BNCT) were experimentally tested with prototype monitors in an appropriate neutron field produced at the intense deuterium-tritium neutron source facility OKTAVIAN of Osaka University, Japan. The experimental test results and related analysis indicated that the performance of the monitors was good and the neutron fluxes from 10keV to 1MeV of practical BNCT neutron sources can be measured within 10% by the monitors. Copyright © 2017 Elsevier Ltd. All rights reserved.
INEL BNCT research program publications, 1993
International Nuclear Information System (INIS)
1994-05-01
This document is a collection of the published reports describing research supporting the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). These reports have previously appeared in the book: Advances in Neutron Capture Therapy, edited by A. H. Soloway, R. F. Barth, D. E. Carpenter, Plenum Press, 1993. Reports have also appeared in three journals: Angewandte Chemie, Strahlentherapie und Onkologie, and Nuclear Science and Engineering. This individual papers have been indexed separately elsewhere
A novel low-complexity digital filter design for wearable ECG devices.
Asgari, Shadnaz; Mehrnia, Alireza
2017-01-01
Wearable and implantable Electrocardiograph (ECG) devices are becoming prevailing tools for continuous real-time personal health monitoring. The ECG signal can be contaminated by various types of noise and artifacts (e.g., powerline interference, baseline wandering) that must be removed or suppressed for accurate ECG signal processing. Limited device size, power consumption and cost are critical issues that need to be carefully considered when designing any portable health monitoring device, including a battery-powered ECG device. This work presents a novel low-complexity noise suppression reconfigurable finite impulse response (FIR) filter structure for wearable ECG and heart monitoring devices. The design relies on a recently introduced optimally-factored FIR filter method. The new filter structure and several of its useful features are presented in detail. We also studied the hardware complexity of the proposed structure and compared it with the state-of-the-art. The results showed that the new ECG filter has a lower hardware complexity relative to the state-of-the-art ECG filters.
A novel low-complexity digital filter design for wearable ECG devices.
Directory of Open Access Journals (Sweden)
Shadnaz Asgari
Full Text Available Wearable and implantable Electrocardiograph (ECG devices are becoming prevailing tools for continuous real-time personal health monitoring. The ECG signal can be contaminated by various types of noise and artifacts (e.g., powerline interference, baseline wandering that must be removed or suppressed for accurate ECG signal processing. Limited device size, power consumption and cost are critical issues that need to be carefully considered when designing any portable health monitoring device, including a battery-powered ECG device. This work presents a novel low-complexity noise suppression reconfigurable finite impulse response (FIR filter structure for wearable ECG and heart monitoring devices. The design relies on a recently introduced optimally-factored FIR filter method. The new filter structure and several of its useful features are presented in detail. We also studied the hardware complexity of the proposed structure and compared it with the state-of-the-art. The results showed that the new ECG filter has a lower hardware complexity relative to the state-of-the-art ECG filters.
Directory of Open Access Journals (Sweden)
SZOPOS, E.
2012-05-01
Full Text Available This paper presents an iterative method for designing FIR filters that implement arbitrary magnitude characteristics, defined by the user through a set of frequency-magnitude points (frequency samples. The proposed method is based on the non-uniform frequency sampling algorithm. For each iteration a new set of frequency samples is generated, by processing the set used in the previous run; this implies changing the samples location around the previous frequency values and adjusting their magnitude through interpolation. If necessary, additional samples can be introduced, as well. After each iteration the magnitude characteristic of the resulting filter is determined by using the non-uniform DFT and compared with the required one; if the errors are larger than the acceptable levels (set by the user a new iteration is run; the length of the resulting filter and the values of its coefficients are also taken into consideration when deciding a re-run. To demonstrate the efficiency of the proposed method a tool for designing FIR filters that match human audiograms was implemented in LabVIEW. It was shown that the resulting filters have smaller coefficients than the standard one, and can also have lower order, while the errors remain relatively small.
Directory of Open Access Journals (Sweden)
Yaqeen S Mezaal
Full Text Available This paper presents new Wide Bandpass Filter (WBPF and Narrow Bandstop Filter (NBSF incorporating two microstrip resonators, each resonator is based on 2nd iteration of Hilbert fractal geometry. The type of filter as pass or reject band has been adjusted by coupling gap parameter (d between Hilbert resonators using a substrate with a dielectric constant of 10.8 and a thickness of 1.27 mm. Numerical simulation results as well as a parametric study of d parameter on filter type and frequency responses are presented and studied. WBPF has designed at resonant frequencies of 2 and 2.2 GHz with a bandwidth of 0.52 GHz, -28 dB return loss and -0.125 dB insertion loss while NBSF has designed for electrical specifications of 2.37 GHz center frequency, 20 MHz rejection bandwidth, -0.1873 dB return loss and 13.746 dB insertion loss. The proposed technique offers a new alternative to construct low-cost high-performance filter devices, suitable for a wide range of wireless communication systems.
Saha, S K; Dutta, R; Choudhury, R; Kar, R; Mandal, D; Ghoshal, S P
2013-01-01
In this paper, opposition-based harmony search has been applied for the optimal design of linear phase FIR filters. RGA, PSO, and DE have also been adopted for the sake of comparison. The original harmony search algorithm is chosen as the parent one, and opposition-based approach is applied. During the initialization, randomly generated population of solutions is chosen, opposite solutions are also considered, and the fitter one is selected as a priori guess. In harmony memory, each such solution passes through memory consideration rule, pitch adjustment rule, and then opposition-based reinitialization generation jumping, which gives the optimum result corresponding to the least error fitness in multidimensional search space of FIR filter design. Incorporation of different control parameters in the basic HS algorithm results in the balancing of exploration and exploitation of search space. Low pass, high pass, band pass, and band stop FIR filters are designed with the proposed OHS and other aforementioned algorithms individually for comparative optimization performance. A comparison of simulation results reveals the optimization efficacy of the OHS over the other optimization techniques for the solution of the multimodal, nondifferentiable, nonlinear, and constrained FIR filter design problems.
Directory of Open Access Journals (Sweden)
S. K. Saha
2013-01-01
Full Text Available In this paper, opposition-based harmony search has been applied for the optimal design of linear phase FIR filters. RGA, PSO, and DE have also been adopted for the sake of comparison. The original harmony search algorithm is chosen as the parent one, and opposition-based approach is applied. During the initialization, randomly generated population of solutions is chosen, opposite solutions are also considered, and the fitter one is selected as a priori guess. In harmony memory, each such solution passes through memory consideration rule, pitch adjustment rule, and then opposition-based reinitialization generation jumping, which gives the optimum result corresponding to the least error fitness in multidimensional search space of FIR filter design. Incorporation of different control parameters in the basic HS algorithm results in the balancing of exploration and exploitation of search space. Low pass, high pass, band pass, and band stop FIR filters are designed with the proposed OHS and other aforementioned algorithms individually for comparative optimization performance. A comparison of simulation results reveals the optimization efficacy of the OHS over the other optimization techniques for the solution of the multimodal, nondifferentiable, nonlinear, and constrained FIR filter design problems.
DEFF Research Database (Denmark)
Niemann, Hans Henrik; Stoustrup, Jakob
1996-01-01
The design problem of filters for robust failure detection and isolation, (FDI) is addressed in this paper. The failure detection problem will be considered with respect to both modeling errors and disturbances. Both an approach based on failure detection observers as well as an approach based on...
Tailored design of WDM filters in BCB embedded PhC membranes
DEFF Research Database (Denmark)
Malaguti, Stefania; Bellanca, Gaetano; Ottaviano, Luisa
2013-01-01
We propose a design strategy for wavelength division multiplexing (WDM) filters in BCB embedded photonic crystal membranes. Due to the weaker vertical confinement determined by the material embedding the whole structure, accurate tailoring of the resonant cavity and of both bus and drop waveguides...
Peterson, A.; Narasimha, M.; Narayan, S.
1980-01-01
The system design of a wideband (8 MHz) million-channel digital spectrum analyzer for use with a SETI receiver is presented. The analyzer makes use of a digital bandpass filter bank for transforming the wideband input signal into a specified number (120) of uniform narrowband output channels by the use of a Fourier transform digital processor combined with a prototype digital weighting network (finite impulse response filter). The output is then processed separately by 120 microprocessor-based discrete Fourier transform computers, each producing 8190 output channels of approximately 8 Hz bandwidth by the use of an 8190-point prime factor algorithm.
Park, Kihong
2013-02-01
In this paper, we study a two-hop relaying network consisting of one source, one destination, and three amplify-and-forward (AF) relays with multiple antennas. To compensate for the capacity prelog factor loss of 1/2$ due to the half-duplex relaying, alternate transmission is performed among three relays, and the inter-relay interference due to the alternate relaying is aligned to make additional degrees of freedom. In addition, suboptimal linear filter designs at the nodes are proposed to maximize the achievable sum rate for different fading scenarios when the destination utilizes a minimum mean-square error filter. © 1967-2012 IEEE.
Proceedings of neutron irradiation technical meeting on BNCT
International Nuclear Information System (INIS)
2000-10-01
The 'Neutron Irradiation Technical Meeting for Boron Neutron Capture Therapy (BNCT)' was held on March 13, 2000 at Tokai Research Establishment. The Meeting is aimed to introduce the neutron beam facility for medical irradiation at JRR-4 to Japanese researchers widely, as well as providing an opportunity for young researchers, engineers, medical representatives such surgeons and doctors of pharmacology to present their research activities and to exchange valuable information. JAERI researcher presented the performance and the irradiation technology in the JRR-4 neutron beam facility, while external researchers made various and beneficial presentations containing such accelerator-based BNCT, spectrum-shifter, biological effect, pharmacological development and so on. In this meeting, a special lecture titled 'The Dawn of BNCT and Its Development.' was given by MD, Prof. Takashi Minobe, an executive director of Japan Foundation for Emergency Medicine. The 11 of the presented papers are indexed individually. (J.P.N.)
Proceedings of neutron irradiation technical meeting on BNCT
Energy Technology Data Exchange (ETDEWEB)
NONE
2000-10-01
The 'Neutron Irradiation Technical Meeting for Boron Neutron Capture Therapy (BNCT)' was held on March 13, 2000 at Tokai Research Establishment. The Meeting is aimed to introduce the neutron beam facility for medical irradiation at JRR-4 to Japanese researchers widely, as well as providing an opportunity for young researchers, engineers, medical representatives such surgeons and doctors of pharmacology to present their research activities and to exchange valuable information. JAERI researcher presented the performance and the irradiation technology in the JRR-4 neutron beam facility, while external researchers made various and beneficial presentations containing such accelerator-based BNCT, spectrum-shifter, biological effect, pharmacological development and so on. In this meeting, a special lecture titled 'The Dawn of BNCT and Its Development.' was given by MD, Prof. Takashi Minobe, an executive director of Japan Foundation for Emergency Medicine. The 11 of the presented papers are indexed individually. (J.P.N.)
Protocols for BNCT of glioblastoma multiforme at Brookhaven: Practical considerations
Energy Technology Data Exchange (ETDEWEB)
Chanana, A.D.; Coderre, J.A.; Joel, D.D.; Slatkin, D.N.
1996-12-31
In this report we discuss some issues considered in selecting initial protocols for boron neutron capture therapy (BNCT) of human glioblastoma multiforme. First the tolerance of normal tissues, especially the brain, to the radiation field. Radiation doses limits were based on results with human and animal exposures. Estimates of tumor control doses were based on the results of single-fraction photon therapy and single fraction BNCT both in humans and experimental animals. Of the two boron compounds (BSH and BPA), BPA was chosen since a FDA-sanctioned protocol for distribution in humans was in effect at the time the first BNCT protocols were written and therapy studies in experimental animals had shown it to be more effective than BSH.
Spectrum shaping assessment of accelerator-based fusion neutron sources to be used in BNCT treatment
Cerullo, N.; Esposito, J.; Daquino, G. G.
2004-01-01
Monte Carlo modelling of an irradiation facility, for boron neutron capture therapy (BNCT) application, using a set of advanced type, accelerator based, 3H(d,n) 4He (D-T) fusion neutron source device is presented. Some general issues concerning the design of a proper irradiation beam shaping assembly, based on very hard energy neutron source spectrum, are reviewed. The facility here proposed, which represents an interesting solution compared to the much more investigated Li or Be based accelerator driven neutron source could fulfil all the medical and safety requirements to be used by an hospital environment.
Beam shaping assembly optimization for (7)Li(p,n)(7)Be accelerator based BNCT.
Minsky, D M; Kreiner, A J
2014-06-01
Within the framework of accelerator-based BNCT, a project to develop a folded Tandem-ElectroStatic-Quadrupole accelerator is under way at the Atomic Energy Commission of Argentina. The proposed accelerator is conceived to deliver a proton beam of 30mA at about 2.5MeV. In this work we explore a Beam Shaping Assembly (BSA) design based on the (7)Li(p,n)(7)Be neutron production reaction to obtain neutron beams to treat deep seated tumors. © 2013 Elsevier Ltd. All rights reserved.
Design and evaluation of a filter-based chairside amalgam separation system
Energy Technology Data Exchange (ETDEWEB)
Stone, Mark E. [Naval Institute for Dental and Biomedical Research, 310A B Street, Great Lakes, Illinois 60088 (United States)], E-mail: mark.stone@yahoo.com; Cohen, Mark E.; Berry, Denise L.; Ragain, James C. [Naval Institute for Dental and Biomedical Research, 310A B Street, Great Lakes, Illinois 60088 (United States)
2008-06-15
This study evaluated the ability of a chairside filtration system to remove particulate-based mercury (Hg) from dental-unit wastewater. Prototypes of the chairside filtration system were designed and fabricated using reusable filter chambers with disposable filter elements. The system was installed in five dental operatories utilizing filter elements with nominal pore sizes of 50{mu}m, 15{mu}m, 1{mu}m, 0.5{mu}m, or with no system installed (control). Daily chairside wastewater samples were collected on ten consecutive days from each room and brought to the laboratory for processing. After processing the wastewater samples, Hg concentrations were determined with cold vapor atomic absorption spectrometry (USEPA method 7470A). Filter systems were exchanged after ten samples were collected so that all five of the configurations were evaluated in each room (with assignment order balanced by a Latin Square). The numbers of surfaces of amalgam placed and removed per day were tracked in each room. In part two, new filter systems with the 0.5{mu}m filter elements were installed in the five dental operatories and vacuum levels at the high-velocity evacuation cannula tip were measured with a vacuum gauge. In part three of the study, the chairside filtration system utilizing 0.5{mu}m and 15{mu}m filter elements was evaluated utilizing the ISO 11143 testing protocol, a laboratory test of amalgam separator efficiency utilizing amalgam samples of known particle size distribution. Mean Hg per chair per day (no filter installed) was 1087.38mg (SD = 993.92mg). Mean Hg per chair per day for the 50{mu}m, 15{mu}m, 1{mu}m, 0.5{mu}m filter configurations was 79.13mg (SD = 71.40mg), 23.55mg (SD = 23.25mg), 17.68mg (SD = 17.35mg), and 4.25mg (SD = 6.35mg), respectively (n = 50 for all groups). Calculated removal efficiencies from the clinical samples were 92.7%, 97.8%, 98.4%, and 99.6%, respectively. ANCOVA on data from the four filter groups, with amalgam-surfaces-removed included as a
Scaling of Supply Voltage in Design of Energy Saver FIR Filter on 28nm FPGA
DEFF Research Database (Denmark)
Pandey, Bishwajeet; Jain, Vishal; Sharma, Rashmi
2017-01-01
In this work, we are going to analyze the effect of main supply voltage, auxiliary supply voltage, local voltage of different power bank, and supply voltage in GTX transceiver and BRAM on power dissipation of our FIR design using Verilog during implementation on 28nm FPGA. We have also taken three.......33%, 86%, 90.67%, 65.33%, 52%, and 48.67% reduction in IO power dissipation of FIR Filter design on CSG324 package of Artix-7 FPGA family....
Adaptive filter design based on the LMS algorithm for delay elimination in TCR/FC compensators.
Hooshmand, Rahmat Allah; Torabian Esfahani, Mahdi
2011-04-01
Thyristor controlled reactor with fixed capacitor (TCR/FC) compensators have the capability of compensating reactive power and improving power quality phenomena. Delay in the response of such compensators degrades their performance. In this paper, a new method based on adaptive filters (AF) is proposed in order to eliminate delay and increase the response of the TCR compensator. The algorithm designed for the adaptive filters is performed based on the least mean square (LMS) algorithm. In this design, instead of fixed capacitors, band-pass LC filters are used. To evaluate the filter, a TCR/FC compensator was used for nonlinear and time varying loads of electric arc furnaces (EAFs). These loads caused occurrence of power quality phenomena in the supplying system, such as voltage fluctuation and flicker, odd and even harmonics and unbalancing in voltage and current. The above design was implemented in a realistic system model of a steel complex. The simulation results show that applying the proposed control in the TCR/FC compensator efficiently eliminated delay in the response and improved the performance of the compensator in the power system. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
Design of adaptive control systems by means of self-adjusting transversal filters
Merhav, S. J.
1986-01-01
The design of closed-loop adaptive control systems based on nonparametric identification was addressed. Implementation is by self-adjusting Least Mean Square (LMS) transversal filters. The design concept is Model Reference Adaptive Control (MRAC). Major issues are to preserve the linearity of the error equations of each LMS filter, and to prevent estimation bias that is due to process or measurement noise, thus providing necessary conditions for the convergence and stability of the control system. The controlled element is assumed to be asymptotically stable and minimum phase. Because of the nonparametric Finite Impulse Response (FIR) estimates provided by the LMS filters, a-priori information on the plant model is needed only in broad terms. Following a survey of control system configurations and filter design considerations, system implementation is shown here in Single Input Single Output (SISO) format which is readily extendable to multivariable forms. In extensive computer simulation studies the controlled element is represented by a second-order system with widely varying damping, natural frequency, and relative degree.
Event-triggered H∞ filter design for delayed neural network with quantization.
Liu, Jinliang; Tang, Jia; Fei, Shumin
2016-10-01
This paper is concerned with H∞ filter design for a class of neural network systems with event-triggered communication scheme and quantization. Firstly, a new event-triggered communication scheme is introduced to determine whether or not the current sampled sensor data should be broadcasted and transmitted to quantizer, which can save the limited communication resource. Secondly, a logarithmic quantizer is used to quantify the sampled data, which can reduce the data transmission rate in the network. Thirdly, considering the influence of the constrained network resource, we investigate the problem of H∞ filter design for a class of event-triggered neural network systems with quantization. By using Lyapunov functional and linear matrix inequality (LMI) techniques, some delay-dependent stability conditions for the existence of the desired filter are obtained. Furthermore, the explicit expression is given for the designed filter parameters in terms of LMIs. Finally, a numerical example is given to show the usefulness of the obtained theoretical results. Copyright © 2016 Elsevier Ltd. All rights reserved.
Sawai, Shujiro; Matsuda, Seiji
Canard based controller using an adaptive notch filter is proposed to control the attitude of launch vehicles including the ISAS's sounding rocket `S-520'. As the characteristics of launch vehicles are time variant in nature, conventional time invariant controller is not suitable for this purpose. Here, adaptive notch filter is proposed to treat the time variant nature. This adaptive filter acts to null out the structural bending mode, which often causes the instability of the attitude controller. The proposed adaptation law requires only limited calculation cost. It means that it is easy to install to the real flight system. The hardware module which aims to control the attitude of the sounding rocket `S-520' is designed and verified not only by the numerical simulations, but also by the hardware tests.
International Nuclear Information System (INIS)
Pozzi, Emiliano; Miller, Marcelo; Thorp, Silvia I.; Heber, Elisa M.; Trivillin, Veronica A.; Zarza, Leandro; Estryk, Guillermo; Schwint, Amanda E.; Nigg, David W.
2007-01-01
Boron Neutron Capture Therapy (BNCT) is a binary treatment modality based on the capture reaction that occurs between thermal neutrons and boron-10 atoms that accumulate selectively in tumor tissue, emitting high linear energy transfer (LET), short range (5-9 microns) particles (alpha y 7 Li). Thus, BNCT would potentially target tumor tissue selectively, sparing normal tissue. Herein we evaluated the feasibility of treating experimental oral mucosa tumors with BNCT at RA-3 (CAE) employing the hamster cheek pouch oral cancer model and characterized the irradiation field at the RA-3 facility. We evaluated the therapeutic effect on tumor of BNCT mediated by BPA in the hamster cheek pouch oral cancer model and the potential radio toxic effects in normal tissue. We evidenced a moderate biological response in tumor, with no radio toxic effects in normal tissue following irradiations with no shielding for the animal body. Given the sub-optimal therapeutic response, we designed and built a 6 Li 2 CO 3 shielding for the body of the animal to increase the irradiation dose to tumor, without exceeding normal tissue radio tolerance. The measured absolute magnitude of thermal neutron flux and the characterization of the beam with and without the shielding in place, suggest that the irradiation facility in the thermal column of RA-3 would afford an excellent platform to perform BNCT studies in vitro and in vivo in small experimental animals. The present findings must be confirmed and extended by performing in vivo BNCT radiobiological studies in small experimental animals, employing the shielding device for the animal body. (author) [es
Development of a tandem-electrostatic-quadrupole accelerator facility for BNCT.
Kreiner, A J; Thatar Vento, V; Levinas, P; Bergueiro, J; Di Paolo, H; Burlon, A A; Kesque, J M; Valda, A A; Debray, M E; Somacal, H R; Minsky, D M; Estrada, L; Hazarabedian, A; Johann, F; Suarez Sandin, J C; Castell, W; Davidson, J; Davidson, M; Giboudot, Y; Repetto, M; Obligado, M; Nery, J P; Huck, H; Igarzabal, M; Fernandez Salares, A
2009-07-01
In this work we describe the present status of an ongoing project to develop a tandem-electrostatic-quadrupole (TESQ) accelerator facility for accelerator-based (AB) BNCT at the Atomic Energy Commission of Argentina in Buenos Aires. The project final goal is a machine capable of delivering 30 mA of 2.4 MeV protons to be used in conjunction with a neutron production target based on the (7)Li(p,n)(7)Be reaction slightly beyond its resonance at 2.25 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the (7)Li(p,n)(7)Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. An electrostatic machine is the technologically simplest and cheapest solution for optimized AB-BNCT. The machine being designed and constructed is a folded TESQ with a high-voltage terminal at 1.2 MV intended to work in air. Such a machine is conceptually shown to be capable of transporting and accelerating a 30 mA proton beam to 2.4 MeV. The general geometric layout, its associated electrostatic fields, and the acceleration tube are simulated using a 3D finite element procedure. The design and construction of the ESQ modules is discussed and their electrostatic fields are investigated. Beam transport calculations through the accelerator are briefly mentioned. Likewise, work related to neutron production targets, strippers, beam shaping assembly and patient treatment room is briefly described.
Ammonia-nitrogen and Phosphate Reduction by Bio-Filter using Factorial Design
Kasmuri, Norhafezah; Ashikin Mat Damin, Nur; Omar, Megawati
2018-02-01
Untreated landfill leachate is known to have endangered the environment. As such new treatment must be sought to ensure its cost-effective and sustainable treatment. Thus this paper reports the effectiveness of bio-filter to remove pollutants. In this research, the reduction of nutrients concentration was evaluated in two conditions: using bio-filter and without bio-filter. Synthetic wastewater was used in the batch culture. It was conducted within 21 days in the initial mediums of 100 mg/L ammonia-nitrogen. The nitrification medium consisted of 100 mg/L of ammonia-nitrogen while the nitrite assay had none. The petri dish experiment was also conducted to observe the existence of any colony. The results showed 22% of ammonia- nitrogen reduction and 33% phosphate in the nitrification medium with the bio-filter. The outcome showed that the bio-filter was capable to reduce the concentration of pollutants by retaining the slow growing bacteria (AOB and NOB) on the plastic carrier surface. The factorial design was applied to study the effect of the initial ammonia-nitrogen concentration and duration on nitrite-nitrogen removal. Finally, a regression equation was produced to predict the rate of nitrite-nitrogen removal without conducting extended experiments and to reduce the number of trials experiment.
Elaborate analysis and design of filter-bank-based sensing for wideband cognitive radios
Maliatsos, Konstantinos; Adamis, Athanasios; Kanatas, Athanasios G.
2014-12-01
The successful operation of a cognitive radio system strongly depends on its ability to sense the radio environment. With the use of spectrum sensing algorithms, the cognitive radio is required to detect co-existing licensed primary transmissions and to protect them from interference. This paper focuses on filter-bank-based sensing and provides a solid theoretical background for the design of these detectors. Optimum detectors based on the Neyman-Pearson theorem are developed for uniform discrete Fourier transform (DFT) and modified DFT filter banks with root-Nyquist filters. The proposed sensing framework does not require frequency alignment between the filter bank of the sensor and the primary signal. Each wideband primary channel is spanned and monitored by several sensor subchannels that analyse it in narrowband signals. Filter-bank-based sensing is proved to be robust and efficient under coloured noise. Moreover, the performance of the weighted energy detector as a sensing technique is evaluated. Finally, based on the Locally Most Powerful and the Generalized Likelihood Ratio test, real-world sensing algorithms that do not require a priori knowledge are proposed and tested.
LCL-Filter Design for Robust Active Damping in Grid-Connected Converters
DEFF Research Database (Denmark)
Pena-Alzola, Rafael; Liserre, Marco; Blaabjerg, Frede
2014-01-01
Grid-connected converters employ LCL-filters, instead of simple inductors, because they allow lower inductances while reducing cost and size. Active damping, without dissipative elements, is preferred to passive damping for solving the associated stability problems. However, large variations...... in the grid inductance may compromise system stability, and this problem is more severe for parallel converters. This situation, typical of rural areas with solar and wind resources, calls for robust LCL-filter design. This paper proposes a design procedure with remarkable results under severe grid inductance...... variation. The procedure considers active damping using lead-lag network and capacitor current feedback. Passive damping is also discussed. The design flow, with little iteration and no complex algorithms, selects the proper ratios between the switching and resonance frequency, the grid and converter...
Design Optimization of Vena Cava Filters: An application to dual filtration devices
Energy Technology Data Exchange (ETDEWEB)
Singer, M A; Wang, S L; Diachin, D P
2009-12-03
Pulmonary embolism (PE) is a significant medical problem that results in over 300,000 fatalities per year. A common preventative treatment for PE is the insertion of a metallic filter into the inferior vena cava that traps thrombi before they reach the lungs. The goal of this work is to use methods of mathematical modeling and design optimization to determine the configuration of trapped thrombi that minimizes the hemodynamic disruption. The resulting configuration has implications for constructing an optimally designed vena cava filter. Computational fluid dynamics is coupled with a nonlinear optimization algorithm to determine the optimal configuration of trapped model thrombus in the inferior vena cava. The location and shape of the thrombus are parameterized, and an objective function, based on wall shear stresses, determines the worthiness of a given configuration. The methods are fully automated and demonstrate the capabilities of a design optimization framework that is broadly applicable. Changes to thrombus location and shape alter the velocity contours and wall shear stress profiles significantly. For vena cava filters that trap two thrombi simultaneously, the undesirable flow dynamics past one thrombus can be mitigated by leveraging the flow past the other thrombus. Streamlining the shape of thrombus trapped along the cava wall reduces the disruption to the flow, but increases the area exposed to abnormal wall shear stress. Computer-based design optimization is a useful tool for developing vena cava filters. Characterizing and parameterizing the design requirements and constraints is essential for constructing devices that address clinical complications. In addition, formulating a well-defined objective function that quantifies clinical risks and benefits is needed for designing devices that are clinically viable.
A New Stochastic Inner Product Core Design for Digital FIR Filters
Directory of Open Access Journals (Sweden)
Wong Ming Ming
2017-01-01
Full Text Available Stochastic computing (SC is a computational technique with computational operations governed by probability instead of arithmetic rules. It recently found promising applications in digital and image processing areas and attracted attentions of researchers. In this paper, a new stochastic inner product (multiply and accumulate core with an improved scaling scheme is presented for improving the accuracy and fault tolerance performance of SC based finite impulse response (FIR digital filters. The proposed inner product core is designed using tree structured multiplexers which is capable of reducing the critical path and fault propagation in the stochastic circuitry. The designed inner product core can lead to construction of SC based light weight and multiplierless FIR digital filters. As a result, an SC based FIR digital FIR filter is implemented on Altera Cyclone V FPGA which operates on stochastic sequences of 256-bits length (8-bits precision level. Experimental results show that the developed filter has lower hardware cost, better accuracy and higher fault tolerance level compared with other stochastic implementations.
Houts, R. C.; Burlage, D. W.
1972-01-01
A time domain technique is developed to design finite-duration impulse response digital filters using linear programming. Two related applications of this technique in data transmission systems are considered. The first is the design of pulse shaping digital filters to generate or detect signaling waveforms transmitted over bandlimited channels that are assumed to have ideal low pass or bandpass characteristics. The second is the design of digital filters to be used as preset equalizers in cascade with channels that have known impulse response characteristics. Example designs are presented which illustrate that excellent waveforms can be generated with frequency-sampling filters and the ease with which digital transversal filters can be designed for preset equalization.
Liu, Zheng; Li, Gang; Liu, Linmao
2014-04-01
This paper involves the feasibility of boron neutron capture therapy (BNCT) for liver tumor with four sealed neutron generators as neutron source. Two generators are placed on each side of the liver. The high energy of these emitted neutrons should be reduced by designing a beam shaping assembly (BSA) to make them useable for BNCT. However, the neutron flux decreases as neutrons pass through different materials of BSA. Therefore, it is essential to find ways to increase the neutron flux. In this paper, the feasibility of using low enrichment uranium as a neutron multiplier is investigated to increase the number of neutrons emitted from D-T neutron generators. The neutron spectrum related to our system has a proper epithermal flux, and the fast and thermal neutron fluxes comply with the IAEA recommended values. Copyright © 2014 Elsevier Ltd. All rights reserved.
Energy Technology Data Exchange (ETDEWEB)
Commandré, Mireille, E-mail: mireille.commandre@fresnel.fr [Centrale Marseille, Aix Marseille Université, CNRS, Institut Fresnel, UMR 7249, 13013 Marseille (France); Vial, Benjamin [Centrale Marseille, Aix Marseille Université, CNRS, Institut Fresnel, UMR 7249, 13013 Marseille (France); Silios Technologies, ZI Peynier-Rousset, rue Gaston Imbert Prolongée, 13790 Peynier (France); Tisserand, Stéphane; Roux, Laurent [Silios Technologies, ZI Peynier-Rousset, rue Gaston Imbert Prolongée, 13790 Peynier (France); Dallaporta, Hervé; Bedu, Frédéric [Aix Marseille Université, CNRS, CiNaM, UMR 7325, Campus de Luminy, Case 913, 13288 Marseille Cedex 9 (France); Demésy, Guillaume; Nicolet, André; Zolla, Frédéric [Centrale Marseille, Aix Marseille Université, CNRS, Institut Fresnel, UMR 7249, 13013 Marseille (France)
2015-10-01
We present the design of infrared filters for multispectral imaging applications, based on square annular aperture arrays in a thin gold film. These structures function as band pass filters with large bandwidth and high transmission at resonance. A modal analysis based on the Finite Element Method (FEM) is performed to obtain quickly the features of this resonance. The center wavelength can be tuned in the 7–12 μm range while keeping constant the quality factor and maximum transmission by scaling all transverse dimensions of the apertures, which allows to obtain filters with different centering on the same substrate in a single fabrication step. Large area samples have been fabricated on a silicon wafer by electronic lithography. Spectrophotometric measurements are in rather good agreement with numerical predictions. In addition, angle resolved measurements show that the filters are quite tolerant to the incidence angle up to 30° for both polarizations which is consistent with our FEM simulations. Finally, a complete sensitivity analysis allows us to evaluate acceptable opto-geometric tolerances of fabrication and thus to improve reproducibility on large areas. The impact of fabrication defaults (rounded corners, aperture anisotropy, aperture edge roughness, sloping aperture edges) on the filtering performances is analyzed. The simulations of realistic structures allow to explain and reduce the differences between measured and simulated spectra. - Highlights: • A theoretical and experimental study of resonant transmission of aperture arrays • Transmission filters in the infrared range are developed for multispectral imaging. • Impact of fabrication defaults, rounded corners, and aperture anisotropy is analyzed. • The simulations of realistic structures increase agreement measurement/simulation.
MODEL-ORIENTED METHOD OF DESIGN IMPLEMENTATION WHEN CREATING DIGITAL FILTERS
Directory of Open Access Journals (Sweden)
V. Levinskyi
2016-12-01
Full Text Available This article discusses the example of model-oriented method of design and development of digital low-pass filters (LPF for automatic control systems (ACS. Typically, high frequency noise and disturbance attenuation is carried out by analogue LPF. However, technical implementation of analogue filters higher than the second order arouse certain difficulties related with the need of precise passive components ratings selection (resistors, capacitors. If the noise and disturbances spectral composition is known, it is possible to build digital LPF with the Nyquist frequency greater than the maximum frequency in the noise spectrum. Such possibility has appeared because of cheap, energy-efficient, high-speed 32-bit microcontrollers market entry. They have analogue signals sampling rate of 30 kHz and above. The traditional approach using the “manual” method of filter parameters calculation, obtaining their recurrence expressions and further program implementation requires high qualification and a lot of time consumption from the developer. An alternative to this approach is the model-oriented method of design (MOMD in MatLab environment when in the one environment the design of digital LPF, verificaton of its performance as a part of the ACS, generation and compilation of program codes for selected microcontroller family take place. MOMD can also be used in the designs of bandpass and bandstop filters for adaptive control systems or systems of technical diagnostics. If during the commissioning or the operation of ACS there is a need in digital LPF parameters change then this operation can be performed within half an hour. MOMD technology allows to significantly reduce the time for developing a specific product without loss of quality in its design ‘cause of extensive possibilities of MatLab development environment.
INEL BNCT Research Program Annual Report 1993
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R.
1994-08-01
This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from all the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, boron drug analysis), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented. Results of 21 spontaneous-tumor-bearing dogs that have been treated with boron neutron capture therapy at the Brookhaven National Laboratory are updated. Boron-containing drug purity verification is discussed in some detail. Advances in magnetic resonance imaging of boron in vivo are discussed. Several boron-carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Measurement of the epithermal-neutron flux of the Petten (The Netherlands) High Flux Reactor beam (HFB11B), and comparison to predictions are shown.
Energy Technology Data Exchange (ETDEWEB)
Andrea Monti Hughes; Emiliano C.C. Pozzi; Elisa M. Heber; Silvia Thorp; Marcelo Miller; Maria E. Itoiz; Romina F. Aromando; Ana J. Molinari; Marcela A. Garabalino; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint
2011-11-01
Given the clinical relevance of locoregional recurrences in head and neck cancer, we developed a novel experimental model of premalignant tissue in the hamster cheek pouch for long-term studies and demonstrated the partial inhibitory effect of a single application of Boron Neutron Capture Therapy (BNCT) on tumor development from premalignant tissue. The aim of the present study was to evaluate the effect of a double application of BNCT with a 6 week interval in terms of inhibitory effect on tumor development, toxicity and DNA synthesis. We performed a double application, 6 weeks apart, of (1) BNCT mediated by boronophenylalanine (BPA-BNCT); (2) BNCT mediated by the combined application of decahydrodecaborate (GB-10) and BPA [(GB-10 + BPA)-BNCT] or (3) beam-only, at RA-3 nuclear reactor and followed the animals for 8 months. The control group was cancerized and sham-irradiated. BPA-BNCT, (GB- 10 + BPA)-BNCT and beam-only induced a reduction in tumor development from premalignant tissue that persisted until 8, 3, and 2 months respectively. An early maximum inhibition of 100% was observed for all 3 protocols. No normal tissue radiotoxicity was detected. Reversible mucositis was observed in premalignant tissue, peaking at 1 week and resolving by the third week after each irradiation. Mucositis after the second application was not exacerbated by the first application. DNA synthesis was significantly reduced in premalignant tissue 8 months post-BNCT. A double application of BPA-BNCT and (GB-10 + BPA)-BNCT, 6 weeks apart, could be used therapeutically at no additional cost in terms of radiotoxicity in normal and dose-limiting tissues.
Design and implementation of FIR filter based on STM32F103x
Directory of Open Access Journals (Sweden)
ZHENG Zhendong
2013-08-01
Full Text Available STM32F1 series processors are based on ST's new generation of ARM cortex-M3 processor core to meet the industrial control，medical，consumer and other areas of application requirements． At the same time，ST companies also launched a set of DSP function library for the STM32F10x series，enabling common digital signal processing． In this paper，a set of FIRfilter design and implementation is proposed for the STM32F10x series． Experiments show that the integer filter coefficients can replace the float coefficients in FIRfilter design． When the sampling rate is 256 samples per second，the FIRfilter is of the order of 128 and takes only 1．5ms to finish filtering 256 samples，fully meeting the design requirements for industrial control systems．
Embedded FIR filter design for real-time refocusing using a standard plenoptic video camera
Hahne, Christopher; Aggoun, Amar
2014-03-01
A novel and low-cost embedded hardware architecture for real-time refocusing based on a standard plenoptic camera is presented in this study. The proposed layout design synthesizes refocusing slices directly from micro images by omitting the process for the commonly used sub-aperture extraction. Therefore, intellectual property cores, containing switch controlled Finite Impulse Response (FIR) filters, are developed and applied to the Field Programmable Gate Array (FPGA) XC6SLX45 from Xilinx. Enabling the hardware design to work economically, the FIR filters are composed of stored product as well as upsampling and interpolation techniques in order to achieve an ideal relation between image resolution, delay time, power consumption and the demand of logic gates. The video output is transmitted via High-Definition Multimedia Interface (HDMI) with a resolution of 720p at a frame rate of 60 fps conforming to the HD ready standard. Examples of the synthesized refocusing slices are presented.
Directory of Open Access Journals (Sweden)
LI Yang
2017-02-01
Full Text Available Aiming at the problem of high frequency noise interference in the ECT data acquisition system，on the basis of analysis of the ECT system data acquisition and control principles，we designed an improved distributed algorithm FIR low-pass digital filter combined with FPGA technology and digital filtering principle. The sampling frequency of the filter is 1 .5 MHz，the pass band cutoff frequency is 20MHz，and the design method is window function. We used the FDATooI toolbox in Matlab to extract and quantify the filter coefficients and the Quarters to simulate the simulation. Experimental results showed that the FIR digital filter can achieve the filtering function of the high frequency signal in the data acquisition system. Compared with the traditional DA algorithm，it has the advantages of small resource consumption and high acquisition speed and some other characteristics.
DEFF Research Database (Denmark)
Tang, Yi; Yao, Wenli; Loh, Poh Chiang
2016-01-01
-switch-based three-phase pulsewidth-modulated converters. Moreover, a single-loop current control strategy is proposed for the designed LCL filter, and the control system is inherently stable without introducing any passive or active damping. Based on the new stability region, two LCL filter design...... examples are given, with one of them optimizing the utilization of passive filter inductors, and another one being robust against grid impedance variation. Comprehensive experimental results, showing the high-quality output current and excellent resonance attenuation, are presented in this paper, which......This paper proposes a novel LCL filter design method and its current control for grid-connected converters. With the proposed design method, it is possible to set the resonance frequency of the LCL filter to be higher than the Nyquist frequency, i.e., half of the system sampling frequency...
INEL BNCT Program: Volume 5, No. 9. Bulletin, September 1991
Energy Technology Data Exchange (ETDEWEB)
Ackermann, A.L. [ed.
1991-12-31
This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Neutron Flux Measurement Produced by BNCT Target using Proton Beam
International Nuclear Information System (INIS)
Ha, Jang Ho; Kim, Yong Kyun; Chai, Jong Seo; Kim, Jong Kyung
2005-01-01
We are investigating neutron production target system performance for boron captured neutron therapy (BNCT). The epithermal neutron is useful for this therapy and in present study we performed a simple method to measure neutron flux and energy, which are important for the accurate cancer therapy. The simple method and result of neutron flux and energy measurement experiment are presented
DeJarnette, Drew; Brekke, Nick; Tunkara, Ebrima; Hari, Parameswar; Roberts, Kenneth; Otanicar, Todd
2015-09-01
A nanoparticle fluid filter used with concentrating hybrid solar/thermal collector design is presented. Nanoparticle fluid filters could be situated on any given concentrating system with appropriate customized engineering. This work shows the design in the context of a trough concentration system. Geometric design and physical placement in the optical path was modeled using SolTrace. It was found that a design can be made that blocks 0% of the traced rays. The nanoparticle fluid filter is tunable for different concentrating systems using various PV cells or operating at varying temperatures.
In vivo BNCT in experimental and spontaneous tumors at RA-1 reactor
International Nuclear Information System (INIS)
Trivillin, Veronica A.; Heber, Elisa M.; Itoiz, Maria E.; Schwint, Amanda E.; Nigg, David W.
2003-01-01
Within the search for new applications of Boron Neutron Capture Therapy (BNCT) and the basic research oriented towards the study of BNCT radiobiology to optimize its therapeutic gain, we previously proposed and validated the hamster cheek pouch oral cancer model and showed, for the first time, the success of BNCT to treat oral cancer in an experimental model. The staff of the Ra-1 Reactor (Constituyentes Atomic Center) adapted the thermal beam and physical set-up to perform in vivo BNCT of superficial tumors in small animals. We preformed a preliminary characterization of the thermal beam, performed beam only irradiation of normal and tumor bearing hamsters and in vivo BNCT of experimental oral squamous cell carcinomas in hamsters mediated by boron phenylalanine (BPA) and GB-10 (Na 2 10 B 10 H 10 ). Having demonstrated the absence of radio toxic effects in healthy tissue and a therapeutic effect of in vivo BNCT in hamster cheek pouch tumors employing the Ra-1 thermal beam, we performed a feasibility study of the treatment by BNCT of 3 terminal cases of spontaneous head and neck squamous cell carcinoma in cats following the corresponding biodistribution studies. This was the first treatment of spontaneous tumors by BNCT in our country and the first treatment by BNCT in cats worldwide. This preclinical study in terminal cases showed significant tumor control by BNCT with no damage to normal tissue. (author)
An update on the clinical trial of BNCT at the BMRR
International Nuclear Information System (INIS)
Ma, R.; Capala, J.; Chanana, A.D.; Coderre, J.A.; Diaz, A.Z.
1999-01-01
Boron neutron capture therapy (BNCT) was proposed more than six decades ago. It is a binary treatment modality that requires selective delivery of a 10 B-labeled compound to a tumor and slow neutron irradiation of the tumor-bearing tissues. In order to improve the penetration of the neutron beam, an epithermal neutron beam was developed at the Brookhaven Medical Research Reactor (BMRR). This epithermal neutron beam can deliver relatively high thermal neutron fluence at depth without severe skin damage. Boronophenylalanine-fructose (BPA-F), a nontoxic boron carrier, was found to preferentially accumulate in tumor cells following intravenous infusion in patients with GBM. In preclinical BNCT studies in rats bearing 9L gliosarcoma, BPA-mediated BNCT was shown to be more efficacious than photon irradiation. In 1994, improvements in the neutron beam and in the understanding of the radiobiology of BPA-mediated BNCT led to the initiation of BNCT trials for human GBM at BMRR using BPA-F and epithermal neutrons. The primary objective of the phase I/II clinical trial of BPA-mediated BNCT at BMRR is to evaluate the safety of the BPA-F-mediated BNCT using epithermal neutrons in patients with GBM at a series of escalating BNCT doses. An incidental objective is to evaluate the therapeutic effectiveness of BNCT at each dose level. For each dose escalation group, the average brain dose (ABD) is escalated, as well as the minimum tumor dose. In summary, the BNCT procedure employed in the phase I/II clinical trial of BPA-F-mediated BNCT for GBM at BNL was found to be safe in all patients. The palliation afforded by a single session of BNCT compares favorably with palliation provided by fractionated photon therapy and adjuvant chemotherapy. If no evidence of radiation-induced brain toxicity is found in the current protocol, BNCT radiation dose will be further escalated
Moving Average Filter-Based Phase-Locked Loops: Performance Analysis and Design Guidelines
DEFF Research Database (Denmark)
Golestan, Saeed; Ramezani, Malek; Guerrero, Josep M.
2014-01-01
this challenge, incorporating moving average filter(s) (MAF) into the PLL structure has been proposed in some recent literature. A MAF is a linear-phase finite impulse response filter which can act as an ideal low-pass filter, if certain conditions hold. The main aim of this paper is to present the control......, the PLL block diagram description is shown, the advantages and limitations are briefly discussed, and the tuning approach (if available) is evaluated. The paper then presents two systematic methods to design the control parameters of a typical MAF-based PLL: one for the case of using a proportional......-integral (PI) type loopfilter (LF) in the PLL, and the other for the case of using a proportional-integral-derivative (PID) type LF. Finally, the paper compares the performance of a well-tuned MAF-based PLL when using the PI-type LF with the results of using the PID-type LF, which provides useful insights...
Hardware design of the median filter based on window structure and batcher′s oddeven sort network
Directory of Open Access Journals (Sweden)
SUN Kaimin
2013-06-01
Full Text Available Area and speed are two important factors to be considered in designing Median Filter with digital circuits.Area consideration requires the use of logical resources as little as possible,while speed consideration requires the system capable of working on higher clock frequencies,with as few clock cycles as possible to complete a frame filtering or real time filtering.This paper gives a new design of Median Filter,the hardware structure of which is a 3×3 window structure with two buffers.The filter function module is based on Batcher′s Odd-Even Sort network theory.Structural design is implemented in FPGA,verified by ModelSim software and realizes video image filtering.The experimental analysis shows that this new structure of Median Filter effectively decreases logical resources (merely using 741 Logic Elements,and accelerates the pixel processing speed up to 27MHz.This filter achieves realtime processing of video images of 30 frames/s.This design not only has a certain practicality,but also provides a reference for the hardware structure design ideas in digital image processing.
Cat Swarm Optimization algorithm for optimal linear phase FIR filter design.
Saha, Suman Kumar; Ghoshal, Sakti Prasad; Kar, Rajib; Mandal, Durbadal
2013-11-01
In this paper a new meta-heuristic search method, called Cat Swarm Optimization (CSO) algorithm is applied to determine the best optimal impulse response coefficients of FIR low pass, high pass, band pass and band stop filters, trying to meet the respective ideal frequency response characteristics. CSO is generated by observing the behaviour of cats and composed of two sub-models. In CSO, one can decide how many cats are used in the iteration. Every cat has its' own position composed of M dimensions, velocities for each dimension, a fitness value which represents the accommodation of the cat to the fitness function, and a flag to identify whether the cat is in seeking mode or tracing mode. The final solution would be the best position of one of the cats. CSO keeps the best solution until it reaches the end of the iteration. The results of the proposed CSO based approach have been compared to those of other well-known optimization methods such as Real Coded Genetic Algorithm (RGA), standard Particle Swarm Optimization (PSO) and Differential Evolution (DE). The CSO based results confirm the superiority of the proposed CSO for solving FIR filter design problems. The performances of the CSO based designed FIR filters have proven to be superior as compared to those obtained by RGA, conventional PSO and DE. The simulation results also demonstrate that the CSO is the best optimizer among other relevant techniques, not only in the convergence speed but also in the optimal performances of the designed filters. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.
International Nuclear Information System (INIS)
Knowles, J.B.
1975-05-01
Thermocouple measurements in heat transfer experiments on AC powered heat transfer rigs are often subject to an unacceptable level of grid frequency induced interference. A very narrow bandstop digital filter is proposed which effectively eliminates such nominal 50 Hz interference as well as its odd harmonics. The operation of digital filters, and the similarities with their analogue counterparts are explained in this report - partly written as a guide to designing digital filters. Listings and operating instructions of a FORTRAN IV computer programme (DIGIT) for designing: low pass, bandpass, bandstop and high pass digital filters are presented. The same FORTRAN programme also enables the designer to assess the effect of reductions in computer word-length on a filter's frequency response and its output noise. These calculations are required in order to specify the minimum word-length necessary for a satisfactory engineering realization on a mini or micro computer. (U.K.)
Directory of Open Access Journals (Sweden)
Apoorva Aggarwal
2015-12-01
Full Text Available In this paper, an optimal design of linear phase digital finite impulse response (FIR highpass (HP filter using the L1-norm based real-coded genetic algorithm (RCGA is investigated. A novel fitness function based on L1 norm is adopted to enhance the design accuracy. Optimized filter coefficients are obtained by defining the filter objective function in L1 sense using RCGA. Simulation analysis unveils that the performance of the RCGA adopting this fitness function is better in terms of signal attenuation ability of the filter, flatter passband and the convergence rate. Observations are made on the percentage improvement of this algorithm over the gradient-based L1 optimization approach on various factors by a large amount. It is concluded that RCGA leads to the best solution under specified parameters for the FIR filter design on account of slight unnoticeable higher transition width.
Directory of Open Access Journals (Sweden)
Osawa Yuta
2017-01-01
Full Text Available Boron Neutron Capture Therapy (BNCT is known to be a new promising cancer therapy suppressing influence against normal cells. In Japan, Accelerator Based Neutron Sources (ABNS are being developed for BNCT. For the spread of ABNS based BNCT, we should characterize the neutron field beforehand. For this purpose, we have been developing a low-energy neutron spectrometer based on 3He position sensitive proportional counter. In this study, a new intense epi-thermal neutron field was developed with a DT neutron source for verification of validity of the spectrometer. After the development, the neutron field characteristics were experimentally evaluated by using activation foils. As a result, we confirmed that an epi-thermal neutron field was successfully developed suppressing fast neutrons substantially. Thereafter, the neutron spectrometer was verified experimentally. In the verification, although a measured detection depth distribution agreed well with the calculated distribution by MCNP, the unfolded spectrum was significantly different from the calculated neutron spectrum due to contribution of the side neutron incidence. Therefore, we designed a new neutron collimator consisting of a polyethylene pre-collimator and boron carbide neutron absorber and confirmed numerically that it could suppress the side incident neutrons and shape the neutron flux to be like a pencil beam.
International Nuclear Information System (INIS)
Sauerwein, W.; Hideghety, K.; Rassow, J.; Devries, M.J.; Goetz, C.; Paquis, P.; Grochulla, F.; Wolbers, J.G.; Haselsberger, K.; Turowski, B.; Moss, R.L.; Stecher-Rasmussen, F.; Touw, D.; Wiestler, O.D.; Frankhauser, H.; Gabel, D.
2001-01-01
Based on the pre-clinical work of the European Collaboration on Boron Neutron Capture Therapy a study protocol was prepared in 1995 to initiate Boron Neutron Capture Therapy (BNCT) in patients at the High Flux Reactor (HFR) in Petten. Bio-distribution and pharmacokinetics data of the boron drug Na 2 B 12 H 11 SH (BSH) as well as the radiobiological effects of BNCT with BSH in healthy brain tissue of dogs were considered in designing the strategy for this clinical Phase I trial. The primary goal of the radiation dose escalation study is the investigation of possible adverse events due to BNCT; i.e. to establish the dose limiting toxicity and the maximal tolerated dose. The treatment is delivered in 4 fractions at a defined average boron concentration in blood. Cohorts of 10 patients are treated per dose group. The starting dose was set at 80% of the dose at which neurological symptoms occurred in preclinical dog experiments following a single fraction. After an observation period of at least 6 months, the dose is increased by 10% for the next cohort if less then three severe side effects related to the treatment occurred. The results of the first cohort are presented here. The evaluated dose level can be considered safe. (author)
Directory of Open Access Journals (Sweden)
Shaeen Kalathil
2016-03-01
Full Text Available Forthcoming software defined radios require filter banks which satisfy stringent specifications efficiently with low implementation complexity. Cosine modulated filter banks (CMFB have simple and efficient design procedure. The different wireless standards have different channel spacing or bandwidths and hence demand non-uniform decomposition of subbands. The non-uniform CMFB can be obtained from a uniform CMFB in a simple and efficient approach by merging the adjacent channels of the uniform CMFB. Very narrow transition width filters with low complexity can be achieved using frequency response masking (FRM filter as prototype filter. The complexity is further reduced by the multiplier-less realization of filter banks in which the least number of signed power of two (SPT terms is achieved by representing the filter coefficients using canonic signed digit (CSD representation and then optimizing using suitable modified meta-heuristic algorithms. Hybrid meta-heuristic algorithms are used in this paper. A hybrid algorithm combines the qualities of two meta-heuristic algorithms and results in improved performances with low implementation complexity. Highly frequency selective filter banks characterized by small passband ripple, narrow transition width and high stopband attenuation with non-uniform decomposition of subbands can be designed with least the implementation complexity, using this approach. A digital channelizer can be designed for SDR implementations, using the proposed approach. In this paper, the non-uniform CMFB is designed for various existing wireless standards.
Energy Technology Data Exchange (ETDEWEB)
McWilliams, T.; Widdoes, Jr., L. C.; Wood, L.
1976-09-30
The design of an extremely high performance programmable digital filter of novel architecture, the LLL Programmable Digital Filter, is described. The digital filter is a high-performance multiprocessor having general purpose applicability and high programmability; it is extremely cost effective either in a uniprocessor or a multiprocessor configuration. The architecture and instruction set of the individual processor was optimized with regard to the multiple processor configuration. The optimal structure of a parallel processing system was determined for addressing the specific Navy application centering on the advanced digital filtering of passive acoustic ASW data of the type obtained from the SOSUS net. 148 figures. (RWR)
Directory of Open Access Journals (Sweden)
Chiung-An Chen
2012-11-01
Full Text Available In this paper, a low-cost, low-power and high performance micro control unit (MCU core is proposed for wireless body sensor networks (WBSNs. It consists of an asynchronous interface, a register bank, a reconfigurable filter, a slop-feature forecast, a lossless data encoder, an error correct coding (ECC encoder, a UART interface, a power management (PWM, and a multi-sensor controller. To improve the system performance and expansion abilities, the asynchronous interface is added for handling signal exchanges between different clock domains. To eliminate the noise of various bio-signals, the reconfigurable filter is created to provide the functions of average, binomial and sharpen filters. The slop-feature forecast and the lossless data encoder is proposed to reduce the data of various biomedical signals for transmission. Furthermore, the ECC encoder is added to improve the reliability for the wireless transmission and the UART interface is employed the proposed design to be compatible with wireless devices. For long-term healthcare monitoring application, a power management technique is developed for reducing the power consumption of the WBSN system. In addition, the proposed design can be operated with four different bio-sensors simultaneously. The proposed design was successfully tested with a FPGA verification board. The VLSI architecture of this work contains 7.67-K gate counts and consumes the power of 5.8 mW or 1.9 mW at 100 MHz or 133 MHz processing rate using a TSMC 0.18 μm or 0.13 μm CMOS process. Compared with previous techniques, this design achieves higher performance, more functions, more flexibility and higher compatibility than other micro controller designs.
A Novel (DDCC-SFG-Based Systematic Design Technique of Active Filters
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M. Fakhfakh
2013-09-01
Full Text Available This paper proposes a novel idea for the synthesis of active filters that is based on the use of signal-flow graph (SFG stamps of differential difference current conveyors (DDCCs. On the basis of an RLC passive network or a filter symbolic transfer function, an equivalent SFG is constructed. DDCCs’ SFGs are identified inside the constructed ‘active’ graph, and thus the equivalent circuit can be easily synthesized. We show that the DDCC and its ‘derivatives’, i.e. differential voltage current conveyors and the conventional current conveyors, are the main basic building blocks in such design. The practicability of the proposed technique is showcased via three application examples. Spice simulations are given to show the viability of the proposed technique.
Optimal filter design to compute the mean of cardiovascular pressure signals.
Ellis, Timothy; McNames, James; Goldstein, Brahm
2008-04-01
The mean pressure is a term used to describe the baseline trend of physiological pressure signals that excludes fluctuations due to the cardiac cycle and, in some cases, the respiratory cycle. In many clinical applications and bedside monitoring devices, the mean pressure is estimated with a 3-8 s moving average. We suggest that the mean pressure is best defined in terms of its frequency domain properties. This definition makes it possible to determine solutions that are both optimal and practical. We demonstrate that established methods of optimal finite impulse response (FIR) filter design produce estimates of the mean pressure that are significantly more accurate than the moving average. These filters have no more computational cost, are less sensitive to artifact, have shorter delays, and greater sensitivity to acute events.
Efficient Architecture and Implementation of Vector Median Filter in Co-Design Context
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N. Masmoudi
2007-09-01
Full Text Available This work presents an efficient fast parallel architecture of the Vector Median Filter (VMF using combined hardware/software (HW/SW implementation. The hardware part of the system is implemented using VHDL language, whereas the software part is developed using C/C++ language. The software part of the embedded system uses the NIOS-II softcore processor and the operating system used is ÃŽÂ¼Clinux. The comparison between the software and HW/SW solutions shows that adding a hardware part in the design attempts to speed up the filtering process compared to the software solution. This efficient embedded system implementation can perform well in several image processing applications.
Design of a Broadband Parallel-Coupled Microstrip Filters without Spurious Resonances
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Maher M. Abd-Elrazzak
2007-01-01
Full Text Available A design of parallel-coupled microstrip bandpass filters without spurious resonance is presented. Two different techniques are used to eliminate this response at twice the passband frequency (2fo. The first one is based on usage of suspended substrate, while the second is carried out by shorting the parallel-coupled lines to the ground plane through two shorting walls. The numerical results show that a broadband filter can be obtained by the suppression of the spurious response. The finite difference time domain (FDTD with the perfect matched layer (PML is used in the present analysis. The obtained results are compared with the available published data and good agreements are found.
A novel patch-field design using an optimized grid filter for passively scattered proton beams
International Nuclear Information System (INIS)
Li Yupeng; Zhang Xiaodong; Dong Lei; Mohan, Radhe
2007-01-01
For tumors with highly complex shapes, a 'patching' strategy is often used in passively scattered proton therapy to match the sharp distal edge of the spread-out Bragg peak (SOBP) of the patch field to the lateral penumbra of the through field at 50% dose level. The differences in the dose gradients at the distal edge and at the lateral penumbra could cause hot and cold doses at the junction. In this note, we describe an algorithm developed to optimize the range compensator design to yield a more uniform dose distribution at the junction. The algorithm is based on the fact that the distal fall-off of the SOBP can be tailored using a grid filter that is placed perpendicular to the beam's path. The filter is optimized so that the distal fall-off of the patch field complements the lateral penumbra fall-off of the through field. In addition to optimizing the fall-off, the optimization process implicitly accounts for the limitations of conventional compensator design algorithms. This algorithm uses simple ray tracing to determine the compensator shape and ignore scatter. The compensated dose distribution may therefore differ substantially from the intended dose distribution, especially when complex heterogeneities are encountered, such as those in the head and neck. In such a case, an adaptive optimization strategy can be used to optimize the 'grid' filter locally considering the tissue heterogeneities. The grid filter thus obtained is superimposed on the original range compensator so that the composite compensator leads to a more uniform dose distribution at the patch junction. An L-shaped head and neck tumor was used to demonstrate the validity of the proposed algorithm. A robustness analysis with focus on range uncertainty effect is carried out. (note)
Energy Technology Data Exchange (ETDEWEB)
Monti Hughes, A.; Heber, E.M. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Pozzi, E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Department of Research and Production Reactors, Ezeiza Atomic Center, CNEA, Buenos Aires (Argentina); Nigg, D.W. [Idaho National Laboratory, Idaho Falls, Idaho (United States); Calzetta, O.; Blaumann, H.; Longhino, J. [Department of Nuclear Engineering, Bariloche Atomic Center, CNEA, Rio Negro (Argentina); Nievas, S.I. [Department of Chemistry, CNEA, Buenos Aires (Argentina); Aromando, R.F. [Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires (Argentina); Itoiz, M.E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Buenos Aires (Argentina); Trivillin, V.A. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina); Schwint, A.E. [Department of Radiobiology, National Atomic Energy Commission (CNEA), Buenos Aires (Argentina)], E-mail: schwint@cnea.gov.ar
2009-07-15
We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na{sub 2}{sup 10}B{sub 10}H{sub 10}) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. We performed boron biodistribution studies followed by in vivo BNCT studies, with 8 months follow-up. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77-100%. The inhibitory effect of BPA-BNCT and (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
A phase-I clinical trial for cranial BNCT at Harvard-MIT
International Nuclear Information System (INIS)
Busse, P.M.; Palmer, M.R.; Harling, O.K.
2000-01-01
Phase I trial designed to determine the maximum tolerable dose to normal tissue for cranial BNCT (Boron Neutron Capture Therapy) irradiations was recently completed at Harvard Medical School and MIT. Twenty-two subjects diagnosed with either glioblastoma multiforme or intracranial melanoma were treated between 1996 and 1999. Subjects received either one or two administrations of boronophenylalanine intravenously at doses between 250 and 350 mg/kg body weight, then exposed in one, two or three fields to epithermal neutrons at the MIT Research Reactor in one or two fractions. Over the course of the study, the maximum normal tissue dose target was increased from 8.8 to 14.2 RBE (Relative Biological Effectiveness) Gy in 10% increments. Subjects have been followed clinically and radiographically. Of those patients surviving beyond six months, no MRI (Magnetic Resonance Image) white-matter changes were observed and no long-term complications attributable to BNCT were evident. Tumor responses were observed, particularly with the melanoma subjects. With increasing doses, difficulties arose from long irradiation times (approximately 3 hours) and the emergence of acute reactions in the skin and mucosa. The trial was stopped in May 1999. Future trials will be initiated with the new high intensity, low background fission converter beam at MIT. (author)
SERA -- An advanced treatment planning system for neutron therapy and BNCT
International Nuclear Information System (INIS)
Nigg, D.W.; Wemple, C.A.; Wessol, D.E.; Wheeler, F.J.; Albright, C.; Cohen, M.; Frandsen, M.; Harkin, G.; Rossmeier, M.
1999-01-01
Detailed treatment planning calculations on a patient-specific basis are required for boron neutron capture therapy (BNCT). Two integrated treatment planning systems developed specifically for BNCT have been in clinical use in the United States over the past few years. The MacNCTPLAN BNCT treatment planning system is used in the clinical BNCT trials that are underway at the Massachusetts Institute of Technology. A second system, BNCT rtpe (BNCT radiation therapy planning environment), developed independently by the Idaho national Engineering and Environmental Laboratory (INEEL) in collaboration with Montana State University (MSU), is used for treatment planning in the current series of BNCT clinical trials for glioblastoma at Brookhaven National Laboratory (BNL). This latter system is also licensed for use at several other BNCT research facilities worldwide. Although the currently available BNCT planning systems have served their purpose well, they suffer from somewhat long computation times (2 to 3 CPU-hours or more per field) relative to standard photon therapy planning software. This is largely due to the need for explicit three-dimensional solutions to the relevant transport equations. The simplifying approximations that work well for photon transport computations are not generally applicable to neutron transport computations. Greater computational speeds for BNCT treatment planning must therefore generally be achieved through the application of improved numerical techniques rather than by simplification of the governing equations. Recent efforts at INEEL and MSU have been directed toward this goal. This has resulted in a new paradigm for this type of calculation and the subsequent creation of the new simulation environment for radiotherapy applications (SERA) treatment planning system for BNCT. SERA is currently in initial clinical testing in connection with the trials at BNL, and it is expected to replace the present BNCT rtpe system upon general release
Design of 2-D Recursive Filters Using Self-adaptive Mutation Differential Evolution Algorithm
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Lianghong Wu
2011-08-01
Full Text Available This paper investigates a novel approach to the design of two-dimensional recursive digital filters using differential evolution (DE algorithm. The design task is reformulated as a constrained minimization problem and is solved by an Self-adaptive Mutation DE algorithm (SAMDE, which adopts an adaptive mutation operator that combines with the advantages of the DE/rand/1/bin strategy and the DE/best/2/bin strategy. As a result, its convergence performance is improved greatly. Numerical experiment results confirm the conclusion. The proposedSAMDE approach is effectively applied to test a numerical example and is compared with previous design methods. The computational experiments show that the SAMDE approach can obtain better results than previous design methods.
Analytical Design of Passive LCL Filter for Three-phase Two-level Power Factor Correction Rectifiers
DEFF Research Database (Denmark)
Kouchaki, Alireza; Nymand, Morten
2017-01-01
This paper proposes a comprehensive analytical LCL filter design method for three-phase two-level power factor correction rectifiers (PFCs). The high frequency converter current ripple generates the high frequency current harmonics that need to be attenuated with respect to the grid standards....... Studying the high frequency current of each element proposes a non-iterative solution for designing an LCL filter. In this paper, the converter current ripple is thoroughly analyzed to generalize the current ripple behavior and find the maximum current ripple for sinusoidal PWM and third-harmonic injection...... PWM. Consequently, the current ripple is used to accurately determine the required filter capacitance based on the maximum charge of the filter capacitor. To choose the grid-side inductance, two methods are investigated. First method uses the structure of the damping to express the grid-side filter...
Frankel, R. J.
1981-05-01
A simple, inexpensive, and efficient method of water treatment for rural communities in Southeast Asia was developed using local materials as filter media. The filter utilizes coconut fiber and burnt rice husks in a two-stage filtering process designed as a gravityfed system without the need for backwashing, and eliminates in most cases the need of any chemicals. The first-stage filter with coconut fiber acts essentially as a substitute for the coagulation and sedimentation phases of conventional water-treatment plants. The second-stage filter, using burnt rice husks, is similar to slow sand filtration with the additional benefits of taste, color and odor removals through the absorption properties of the activated carbon in the medium. This paper reports on the design, construction costs, and operating results of several village size units in Thailand and in the Philippines.
Aguilar-González, Pablo Mario; Kober, Vitaly
2010-08-01
Classical correlation filters for object detection and location estimation are designed under the assumption that the shape and intensity values of the object of interest are explicitly known. In this work we assume that the target is given at unknown coordinates in a reference image with a cluttered background corrupted by additive noise. We consider the nonoverlapping signal model for both the reference image and the input scene. Optimal correlation filters, with respect to signal-to-noise ratio and peak-to-output energy, for object detection and location estimation are derived. Estimation techniques are proposed for the parameters required for filter design. Computer simulation results obtained with the proposed filters are presented and compared with those of common correlation filters.
Boron Neutron Capture Therapy at the TRIGA Mark II of Pavia, Italy - The BNCT of the diffuse tumours
International Nuclear Information System (INIS)
Altieri, S.; Bortolussi, S.; Stella, S.; Bruschi, P.; Gadan, M.A.
2008-01-01
samples that cannot be cut into thin slices (bone). The beam and set-up design (MCNP calcs) is underway. Another project concerns the in vivo BNCT irradiating of rats with pulmonary metastases and infused with BPA in the thermal column of the TRIGA reactor. A study is underway to design the shielding and the dose distribution inside the lungs and the radiosensitive organs of the animal. (Simulations by MCNP, construction of a phantom for the n flux measurement by activation method)
DEFF Research Database (Denmark)
Tang, Yi; Yao, Wenli; Loh, Poh Chiang
2015-01-01
-switch based three-phase pulse-width modulated (PWM) converters. Moreover, a single-loop current control strategy is proposed for the designed LCL-filter, and the control system is inherently stable without introducing any passive or active damping. Experimental results, showing the high quality output......This paper proposes a novel LCL-filter design method and its current control for grid-connected converters. With the proposed design method, it is possible to set the resonance frequency of the LCL-filter to be higher than the Nyquist frequency, i.e. half of the system sampling frequency......, and this observation is so far not discussed in the literature. In this case, very cost-effective LCL-filter design can be achieved for grid-connected converters whose dominant switching harmonics may appear at double of the switching frequency, e.g. in unipolar modulated three-level full bridge converters and 12...
A Design of a Terahertz Microstrip Bandstop Filter with Defected Ground Structure
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Arjun Kumar
2013-01-01
Full Text Available A planar microstrip terahertz (THz bandstop filter has been proposed with defected ground structure with high insertion loss (S21 in a stopband of −25.8 dB at 1.436 THz. The parameters of the circuit model have been extracted from the EM simulation results. A dielectric substrate of Benzocyclobutene (BCB is used to realize a compact bandstop filter using modified hexagonal dumbbell-shape defected ground structure (DB-DGS. In this paper, a defected ground structure topology is used in a λ/4, 50 Ω microstrip line at THz frequency range for compactness. No article has been reported on the microstrip line at terahertz frequency regime using DGS topology. The proposed filter can be used for sensing and detection in biomedical instruments in DNA testing. All the simulations/cosimulations are carried out using a full-wave EM simulator CST V.9 Microwave Studio, HFSS V.10, and Agilent Design Suite (ADS.
H-/H∞ structural damage detection filter design using an iterative linear matrix inequality approach
International Nuclear Information System (INIS)
Chen, B; Nagarajaiah, S
2008-01-01
The existence of damage in different members of a structure can be posed as a fault detection problem. It is also necessary to isolate structural members in which damage exists, which can be posed as a fault isolation problem. It is also important to detect the time instants of occurrence of the faults/damage. The structural damage detection filter developed in this paper is a model-based fault detection and isolation (FDI) observer suitable for detecting and isolating structural damage. In systems, possible faults, disturbances and noise are coupled together. When system disturbances and sensor noise cannot be decoupled from faults/damage, the detection filter needs to be designed to be robust to disturbances as well as sensitive to faults/damage. In this paper, a new H - /H ∞ and iterative linear matrix inequality (LMI) technique is developed and a new stabilizing FDI filter is proposed, which bounds the H ∞ norm of the transfer function from disturbances to the output residual and simultaneously does not degrade the component of the output residual due to damage. The reduced-order error dynamic system is adopted to form bilinear matrix inequalities (BMIs), then an iterative LMI algorithm is developed to solve the BMIs. The numerical example and experimental verification demonstrate that the proposed algorithm can successfully detect and isolate structural damage in the presence of measurement noise
Design and engineering of IZO/Ag/glass solar filters for low-emissivity window performance
Hernandez-Mainet, Luis C.; Aguilar, Miguel A.; Tamargo, Maria C.; Falcony, Ciro
2017-10-01
The electricity consumption in houses and commercial buildings generates about 18% of greenhouse gas emission. A critical issue of building energy consumption is heat and cooling loss through the window. Low-emissivity windows control thermal radiation through glass without decreasing the intensity of visible light. They are made up of optical filter coatings grown on a flat glass surface. Solar filters based on Ag/IZO multilayer films are grown and simulated on glass substrate. The targeted structure designs are grown by a sputtering system and characterized by scanning electron microscopy and x-ray diffraction techniques. To accurately simulate transmission spectrum, silver (Ag) and IZO optical constants were estimated by fitting ellipsometric data at different thicknesses. Transmission spectrum shows a good agreement among experiment and simulation. In addition, optical constant curves strongly show layer thickness dependence in both materials. In particular, the ultrathin Ag layer displays a percolation threshold in the vicinity of 15 nm, which leads to surface plasmon resonance with absorption at about 450 nm. These types of optical filter coatings would have potential applications as low-emission windows.
International Nuclear Information System (INIS)
Chadha, Manjeet; Capala, Jacek; Coderre, Jeffrey A.; Elowitz, Eric H.; Joel, Darrel D.; Hungyuan, B. Liu; Slatkin, Daniel N.; Chanana, Arjun D.
1996-01-01
Objective: BNCT is a binary treatment modality based on the nuclear reactions that occur when boron ( 10 B) is exposed to thermal neutrons. Preclinical studies have demonstrated the therapeutic efficacy of p-boronophenylalanine (BPA)-based BNCT. The objective of the Phase I/II trial was to evaluate BPA-fructose (BPA-F) as a boron delivery agent for GBM and to study the feasibility and safety of a single-fraction of BNCT. Materials and Methods: The trial design required i) a BPA-F biodistribution study performed at the time of craniotomy; and ii) BNCT within 4 weeks of the craniotomy. From September 94 to July 95, 10 patients with biopsy proven GBM were treated. All but 1 patient underwent a biodistribution study receiving IV BPA-F at the time of craniotomy. Multiple tissue samples and concurrent blood and urine samples were collected for evaluation of the boron concentration and clearance kinetics. For BNCT all patients received 250 mg/kgm of BPA-F (IV infusion over 2 hrs) followed by neutron irradiation. The blood 10 B concentration during irradiation was used to calculate the time of neutron exposure. The 3D treatment planning was done using the BNCT treatment planning software developed at the Idaho National Engineering Laboratory. The BNCT dose is expressed as the sum of the physical dose components corrected for both the RBE and the 10 B localization factor with the unit Gy-Eq. The photon-equivalent dose, where the thermal neutron fluence reaches a maximum, is the peak-dose equivalent. A single-fraction of BNCT was delivered prescribing 10.5 Gy-Eq (9 patients) and 13.8 Gy-Eq (1 patient) as the peak dose-equivalent to the normal brain. The peak dose rate was kept below 27 cGy-Eq/min. Results: Biodistribution data: The maximum blood 10 B concentration was observed at the end of the infusion and scaled as a linear function of the administered dose. The 10 B concentration in the scalp and in the GBM tissue was higher than in blood by 1.5 x and at least 3.5 x
Chebyshev Functions-Based New Designs of Halfband Low/Highpass Quasi-Equiripple FIR Digital Filters
Directory of Open Access Journals (Sweden)
Ohba Ryoji
2003-01-01
Full Text Available Chebyshev functions, which are equiripple in a certain domain, are used to generate equiripple halfband lowpass frequency responses. Inverse Fourier transformation is then used to obtain explicit formulas for the corresponding impulse responses. The halfband lowpass FIR digital filters designed in this way are quasi-equiripple, having performances very close to those of true equiripple filters, and are comparatively much simpler to design.
Design and analysis of a multi-passband complex filter for the multiband cognitive radar system
Lee, Hua-Chin; Ting, Der-Hong; Tsao, Ya-Lan
2017-05-01
Multiband cognitive radar systems, operating in a variety of frequency bands and combining the different channels into a joint system, can provide significant flexibility and capability to detect and track hostile targets. This paper proposes a multi-passband complex filter (MPCF) architecture and the related circuit design for a multiband cognitive radar system. By operating under the 5.8GHz UNII band, the sensing part detects the current usage of frequency bands from 5.15GHz to 5.825GHz and provides the information of unused channels. The multiband cognitive radar system uses the whole unused channels and eliminates the used channels by using an on-chip MPCF in order to be coexistent with the Wi-Fi standard. The MPCF filters out the unwanted channels and leave the wanted channels. It dynamically changes the bandwidth of frequency from 20MHz to 80MHz using the 0.18μm CMOS technology. The MPCF is composed of the combination of 5th-order Chebyshev low-pass filters and high-pass filters, and the overall inband ripple of the MPCF is 1.2dB. The consuming current is 21.7mA at 1.8V power supply and the 20MHz bandwidth noise is 55.5nV. The total harmonic distortion (THD) is 45dB at 25MHz and the adjacent channel rejection is 24dB. The result of the MPCF guarantees the performance requirements of the multiband cognitive radar system.
Directory of Open Access Journals (Sweden)
Moret Nicola
2010-01-01
Full Text Available Abstract We address the efficient realization of a filtered multitone (FMT modulation system and its orthogonal design. FMT modulation can be viewed as a Discrete Fourier Transform (DFT modulated filter bank (FB. It generalizes the popular orthogonal frequency division multiplexing (OFDM scheme by deploying frequency confined subchannel pulses. We compare three realizations that have been described by Cvetković and Vetterli (1998, and Weiss and Stewart (2000, and Tonello (2006. A detailed derivation of them is performed in the time-domain via the exploitation of different FB polyphase decompositions. We then consider the design of an orthogonal FMT system and we exploit the third realization which allows simplifying the orthogonal FB design and obtaining a block diagonal system matrix with independent subblocks. A numerical method is then presented to obtain an orthogonal FB with well frequency confined subchannel pulses for arbitrarily large number of subchannels. Several examples of pulses with minimal length are reported and their performance is evaluated in typical multipath fading channels. Finally, we compare the orthogonal FMT system with a cyclically prefixed OFDM system in the IEEE 802.11 wireless LAN channel. In this scenario, FMT with minimal length pulses and single tap subchannel equalization outperforms the OFDM system in achievable rate.
Directory of Open Access Journals (Sweden)
Andrea M. Tonello
2010-01-01
Full Text Available We address the efficient realization of a filtered multitone (FMT modulation system and its orthogonal design. FMT modulation can be viewed as a Discrete Fourier Transform (DFT modulated filter bank (FB. It generalizes the popular orthogonal frequency division multiplexing (OFDM scheme by deploying frequency confined subchannel pulses. We compare three realizations that have been described by Cvetković and Vetterli (1998, and Weiss and Stewart (2000, and Tonello (2006. A detailed derivation of them is performed in the time-domain via the exploitation of different FB polyphase decompositions. We then consider the design of an orthogonal FMT system and we exploit the third realization which allows simplifying the orthogonal FB design and obtaining a block diagonal system matrix with independent subblocks. A numerical method is then presented to obtain an orthogonal FB with well frequency confined subchannel pulses for arbitrarily large number of subchannels. Several examples of pulses with minimal length are reported and their performance is evaluated in typical multipath fading channels. Finally, we compare the orthogonal FMT system with a cyclically prefixed OFDM system in the IEEE 802.11 wireless LAN channel. In this scenario, FMT with minimal length pulses and single tap subchannel equalization outperforms the OFDM system in achievable rate.
Plasma grid design for optimized filter field configuration for the NBI test facility ELISE
Energy Technology Data Exchange (ETDEWEB)
Nocentini, R. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, D-85740 Garching (Germany)], E-mail: riccardo.nocentini@ipp.mpg.de; Gutser, R.; Heinemann, B.; Froeschle, M.; Riedl, R. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, D-85740 Garching (Germany)
2009-12-15
Maintenance-free RF sources for negative hydrogen ions with moderate extraction areas (100-200 cm{sup 2}) have been successfully developed in the last years at IPP Garching in the test facilities BATMAN and MANITU. A facility with larger extraction area (1000 cm{sup 2}), ELISE, is being designed with a 'half-size' ITER-like extraction system, pulsed ion acceleration up to 60 kV for 10 s and plasma generation up to 1 h. Due to the large size of the source, the magnetic filter field (FF) cannot be produced solely by permanent magnets. Therefore, an additional magnetic field produced by current flowing through the plasma grid (PG current) is required. The filter field homogeneity and the interaction with the electron suppression magnetic field have been studied in detail by finite element method (FEM) during the ELISE design phase. Significant improvements regarding the field homogeneity have been introduced compared to the ITER reference design. Also, for the same PG current a 50% higher field in front of the grid has been achieved by optimizing the plasma grid geometry. Hollow spaces have been introduced in the plasma grid for a more homogeneous PG current distribution. The introduction of hollow spaces also allows the insertion of permanent magnets in the plasma grid.
Design of a Balun Bandpass Filter with Asymmetrical Coupled Microstrip Lines
Wang, Xuedao; Wang, Jianpeng; Zhang, Gang; Huang, Feng
2017-07-01
A new microstrip coupled-line balun topology and its application to the balun bandpass filter (BPF) with a triple mode response are proposed in this paper. The involved balun structure is composed of two back-to-back quarter-wavelength (λ/4) asymmetrical coupled-line sections. Detailed design formulas based on the asymmetrical coupled-line theory are given to validate the feasibility of the balun. Besides, to obtain filtering performance simultaneously, the balun is then effectively integrated with a pair of triple mode resonators. To demonstrate the design concept of the balun BPF, a prototype operating at 2.4 GHz with the fractional bandwidth (FBW) of about 19.2 % is designed, fabricated, and measured. Results indicate that between the two balanced outputs, the amplitude imbalance is less than 0.3 dB and the phase difference is within 180°±5° inside the whole passband. Both simulated and experimental results are in good agreement.
Moret, Nicola; Tonello, Andrea M.
2010-12-01
We address the efficient realization of a filtered multitone (FMT) modulation system and its orthogonal design. FMT modulation can be viewed as a Discrete Fourier Transform (DFT) modulated filter bank (FB). It generalizes the popular orthogonal frequency division multiplexing (OFDM) scheme by deploying frequency confined subchannel pulses. We compare three realizations that have been described by Cvetković and Vetterli (1998), and Weiss and Stewart (2000), and Tonello (2006). A detailed derivation of them is performed in the time-domain via the exploitation of different FB polyphase decompositions. We then consider the design of an orthogonal FMT system and we exploit the third realization which allows simplifying the orthogonal FB design and obtaining a block diagonal system matrix with independent subblocks. A numerical method is then presented to obtain an orthogonal FB with well frequency confined subchannel pulses for arbitrarily large number of subchannels. Several examples of pulses with minimal length are reported and their performance is evaluated in typical multipath fading channels. Finally, we compare the orthogonal FMT system with a cyclically prefixed OFDM system in the IEEE 802.11 wireless LAN channel. In this scenario, FMT with minimal length pulses and single tap subchannel equalization outperforms the OFDM system in achievable rate.
Design of Dual-Band Bandpass Filter Using Dual-Mode Defected Stub Loaded Resonator
Directory of Open Access Journals (Sweden)
Dechang Huang
2014-01-01
Full Text Available A novel approach for designing a dual-band bandpass filter (BPF using defected stub loaded resonator (DSLR is presented in this paper. The proposed DSLR consists of two fundamental resonant modes and some resonant characteristics have been investigated by EM software of Ansoft HFSS. Then, based on two coupled DSLRs, a dual-band response BPF that operates at 2.4 GHz and 3.5 GHz is designed and implemented for WLAN and WIMAX application. The first passband is constructed by two lower frequencies of the coupled DSLRs and the second passband is produced by two higher ones; the coupling scheme of them is also given. Finally, the dual-band BPF is fabricated and measured; a good agreement between simulation and measurement is obtained, which verifies the validity of the design methodology.
Improvement of neutron irradiation field of research reactors for BNCT
International Nuclear Information System (INIS)
Aizawa, Otohiko
1992-01-01
The modification of research reactors for an improvement of the irradiation field for BNCT has been investigated in comparison with the field characteristics of the 'old' configuration at the Musashi reactor. The new point of this study is that the evaluation has been done by using an arrangement including both the facility structure and a whole-body phantom, and also by considering the whole-body absorbed dose. (author)
DEFF Research Database (Denmark)
Kouchaki, Alireza; Nymand, Morten
2016-01-01
This paper presents LCL filter design method for three-phase two-level power factor correction (PFC) using line impedance stabilization network (LISN). A straightforward LCL filter design along with variation in grid impedance is not simply achievable and inevitably lead to an iterative solution...... for filter. By introducing of fast power switches for PFC applications such as silicon-carbide, major current harmonics around the switching frequency drops in the region that LISN can actively provide well-defined impedance for measuring the harmonics (i.e. 9 kHz- 30MHz). Therefore, LISN can be replaced...... is derived using the current ripple behavior of converter-side inductor. The grid-side inductor is achieved as a function of LISN impedance to fulfill the grid regulation. To verify the analyses, an LCL filter is designed for a 5 kW SiC-based PFC. The simulation and experimental results support the validity...
An efficient closed-form design method for nearly perfect reconstruction of non-uniform filter bank.
Kumar, A; Pooja, R; Singh, G K
2016-03-01
In this paper, an efficient closed form method for the design of multi-channel nearly perfect reconstruction of non-uniform filter bank with the prescribed stopband attenuation and channel overlapping is presented. In this method, the design problem of multi-channel non-uniform filter bank (NUFB) is considered as the design of a prototype filter whose magnitude response at quadrature frequency is 0.707, which is exploited for finding the optimum passband edge frequency through empirical formula instead of using single or multivariable optimization technique. Two main attributes used in assessing the performance of filter bank are peak reconstruction error (PRE) and computational time (CPU time). As compared to existing methods, this method is very simple and easy to implement for NUFBs. To implement this algorithm, a Matlab program has been developed, and several examples are presented to illustrate the performance of proposed method. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.
Optimization of the application of BNCT to undifferentiated thyroid cancer
International Nuclear Information System (INIS)
Dagrosa, M.A.; Thomasz, L.; Longhino, J.
2006-01-01
The possible increase in BNCT efficacy for undifferentiated thyroid carcinoma (UTC) using BPA plus BOPP and nicotinamide (NA) as a radiosensitizer on the BNCT reaction was analyzed. In these studies nude mice were transplanted with the ARO cells and after 14 days they were treated as follows: 1) Control; 2) NCT (neutrons alone); 3) NCT plus NA (100 mg/kg bw/day for 3 days); 4) BPA (350 mg/kg bw) + neutrons; 5) BPA+ NA+ neutrons; 6) BPA+BOPP (60 mg/kg bw) + neutrons. The flux of hyperthermal neutrons was 2.8 10 8 during 85 min. Neutrons alone or with NA caused some tumor growth delay, while in the BPA, BPA+NA and BPA+BOPP groups a 100% halt of tumor growth was observed. When the initial tumor volume was 50 mm 3 or less a complete cure was found in BPA+NA (2/2); BPA (1/4); BPA+BOPP (7/7). After 90 days of complete regression, recurrence of tumor was observed in 2/2 BPA/NA (2/2) and BPA+BOPP (1/7). Caspase 3 activity was increased in BPA+NA (p<0.05 vs controls). BPA plus NA increased tumor apoptosis but only the combination of BPA+BOPP increased significantly BNCT efficiency. (author)
In vitro biological models in order to study BNCT
International Nuclear Information System (INIS)
Dagrosa, Maria A.; Kreimann, Erica L.; Schwint, Amanda E.; Juvenal, Guillermo J.; Pisarev, Mario A.; Farias, Silvia S.; Garavaglia, Ricardo N.; Batistoni, Daniel A.
1999-01-01
Undifferentiated thyroid carcinoma (UTC) lacks an effective treatment. Boron neutron capture therapy (BNCT) is based on the selective uptake of 10 B-boronated compounds by some tumours, followed by irradiation with an appropriate neutron beam. The radioactive boron originated ( 11 B) decays releasing 7 Li, gamma rays and alpha particles, and these latter will destroy the tumour. In order to explore the possibility of applying BNCT to UTC we have studied the biodistribution of BPA. In vitro studies: the uptake of p- 10 borophenylalanine (BPA) by the UTC cell line ARO, primary cultures of normal bovine thyroid cells (BT) and human follicular adenoma (FA) thyroid was studied. No difference in BPA uptake was observed between proliferating and quiescent ARO cells. The uptake by quiescent ARO, BT and FA showed that the ARO/BT and ARO/FA ratios were 4 and 5, respectively (p< 0.001). The present experimental results open the possibility of applying BNCT for the treatment of UTC. (author)
A Tandem-electrostatic-quadrupole for accelerator-based BNCT
International Nuclear Information System (INIS)
Kreiner, A.J.; Kwan, J.W.; Burlon, A.A.; Di Paolo, H.; Henestroza, E.; Minsky, D.M.; Valda, A.A.; Debray, M.E.; Somacal, H.
2007-01-01
A project to develop a Tandem-electrostatic-quadrupole (TESQ) accelerator for accelerator-based boron neutron capture therapy (AB-BNCT) is described. A folded Tandem, with 1.25 MV terminal voltage, combined with an electrostatic quadrupole (ESQ) chain is being proposed. The project goal is a machine capable of delivering 30 mA of 2.5 MeV protons to be used in conjunction with a neutron production target based on the 7 Li(p, n) 7 Be reaction slightly beyond its resonance at 2.25 MeV. This machine is conceptually shown to be capable of accelerating a 30 mA proton beam to 2.5 MeV. These are the specifications needed to produce sufficiently intense and clean epithermal neutron beams, based on the 7 Li(p, n) 7 Be reaction, to perform BNCT treatment for deep-seated tumors in less than an hour. This electrostatic machine is the technologically simplest and cheapest solution for optimized AB-BNCT
Medical setup of intraoperative BNCT at JRR-4
Energy Technology Data Exchange (ETDEWEB)
Akutsu, H.; Yamamoto, T.; Matsumura, A. [Tsukuba Univ., Ibaraki (Japan)] [and others
2000-10-01
Since October 1999, we have been performing clinical trials of intraoperative boron neutron capture therapy (IOBNCT) using a mixed thermal-epithermal beam at the Japan Research Reactor No. 4 (JRR-4). For immediate pre-BNCT care, including administration of a boron compound as well as post-BNCT care, a collaborating neurosurgical department of the University of Tsukuba was prepared in the vicinity of JRR-4. Following craniotomy in the treatment room, anesthetized patients were transported into the irradiation room for BNCT. The boron concentration in tissue was measured by the PGA and ICP-AES methods. The long-term follow-up was done at the University of Tsukuba Hospital. IOBNCT is a complex clinical procedure, which requires sophisticated operating team and co-medical staffs and also cooperation with physicist team. IOBNCT is a complex clinical procedure requiring a high level of cooperation among the operating team, co-medical staff, and physicists. For the safe and successful performance of IOBNCT, we have made the program including critical pathway and prepared various equipments for IOBNCT. To ensure the safe and successful performance of IOBNCT, we developed a critical pathway for use during the procedure, and prepared various apparatus for IOBNCT. (author)
Clinical results of BNCT for malignant brain tumors in children
International Nuclear Information System (INIS)
Nakagawa, Yoshinobu; Kageji, Teruyoshi; Mizobuchi, Yoshifumi; Kumada, Hiroaki; Nakagawa, Yoshiaki
2009-01-01
It is very difficult to treat the patients with malignant brain tumor in children, especially under 3 years, because the conventional irradiation cannot be applied due to the damage of normal brain tissue. However, boron neutron capture therapy (BNCT) has tumor selectivity such that it can make damage only in tumor cells. We evaluated the clinical results and courses in patients with malignant glioma under 15 years. Among 183 patients with brain tumors treated by our group using BSH-based intra-operative BNCT, 23 patients were under 15 years. They included 4 patients under 3 years. There were 3 glioblastomas (GBM), 6 anaplastic astrocytomas(AAS), 7 primitive neuroectodermal tumors (PNET), 6 pontine gliomas and 1 anaplastic ependymoma. All GBM and PNET patients died due to CSF and/or CNS dissemination without local tumor regrowth. All pontine glioma patients died due to regrowth of the tumor. Four of 6 anaplastic astrocytoma and 1 anaplastic ependymoma patients alive without tumor recurrence. BNCT can be applied to malignant brain tumors in children, especially under 3 years instead of conventional radiation. Although it can achieve the local control in the primary site, it cannot prevent CSF dissemination in patients with glioblastoma.
Energy Technology Data Exchange (ETDEWEB)
Hernandez, Antonio Carlos
2002-07-01
Boron Neutron Capture Therapy - BNCT - is a selective cancer treatment and arises as an alternative therapy to treat cancer when usual techniques - surgery, chemotherapy or radiotherapy - show no satisfactory results. The main proposal of this work is to project a facility to BNCT studies. This facility relies on the use of an Am Be neutron source and on a set of moderators, filters and shielding which will provide the best neutron/gamma beam characteristic for these Becton studies, i.e., high intensity thermal and/or epithermal neutron fluxes and with the minimum feasible gamma rays and fast neutrons contaminants. A computational model of the experiment was used to obtain the radiation field in the sample irradiation position. The calculations have been performed with the MCNP 4B Monte Carlo Code and the results obtained can be regarded as satisfactory, i.e., a thermal neutron fluencyN{sub T} = 1,35x10{sup 8} n/cm , a fast neutron dose of 5,86x10{sup -10} Gy/N{sub T} and a gamma ray dose of 8,30x10{sup -14} Gy/N{sub T}. (author)
Tamaki, S; Sakai, M; Yoshihashi, S; Manabe, M; Zushi, N; Murata, I; Hoashi, E; Kato, I; Kuri, S; Oshiro, S; Nagasaki, M; Horiike, H
2015-12-01
Mock-up experiment for development of accelerator based neutron source for Osaka University BNCT project was carried out at Birmingham University, UK. In this paper, spatial distribution of neutron flux intensity was evaluated by foil activation method. Validity of the design code system was confirmed by comparing measured gold foil activities with calculations. As a result, it was found that the epi-thermal neutron beam was well collimated by our neutron moderator assembly. Also, the design accuracy was evaluated to have less than 20% error. Copyright © 2015 Elsevier Ltd. All rights reserved.
A shielding design for an accelerator-based neutron source for boron neutron capture therapy
Energy Technology Data Exchange (ETDEWEB)
Hawk, A.E.; Blue, T.E. E-mail: blue.1@osu.edu; Woollard, J.E
2004-11-01
Research in boron neutron capture therapy (BNCT) at The Ohio State University Nuclear Engineering Department has been primarily focused on delivering a high quality neutron field for use in BNCT using an accelerator-based neutron source (ABNS). An ABNS for BNCT is composed of a proton accelerator, a high-energy beam transport system, a {sup 7}Li target, a target heat removal system (HRS), a moderator assembly, and a treatment room. The intent of this paper is to demonstrate the advantages of a shielded moderator assembly design, in terms of material requirements necessary to adequately protect radiation personnel located outside a treatment room for BNCT, over an unshielded moderator assembly design.
Design and construction of a Wien velocity filter for AMS facilities
Catana, D; Enachescu, M; Plostinaru, V D; Vata, I; Rohrer, L
2001-01-01
Many experiments in atomic and nuclear physics using accelerated particles require accurate ion beams with respect to their atomic number, mass number and ion charge. These requirements have special important for experiments of accelerated mass spectrometry. Double focussing analyzing magnets perform the mass selection of charged ions. However, the magnetic analyzer cannot distinguish between particles with equal charge and having the same mass-velocity product. A simple way of resolving this degeneracy is to use a Wien velocity filter, WVF, in conjunction with the magnet analyzers. The design and construction of a WVF is presented together with experiments performed to determine the separation power. A velocity separation DELTA v/v = 1/100 was obtained. The design in this separate arrangements of fields is simple and straightforward. The construction can be achieved in a usual workshop. The applications of the WVF are manifold, e.g., AMS, ERDA, RBS, etc. (authors)
Design of a Dual-Band Bandpass Filter Using an Open-Loop Resonator
Directory of Open Access Journals (Sweden)
Hyun-Seo Im
2017-10-01
Full Text Available In this paper, we present a novel design for a dual-band bandpass filter (BPF based on the conventional second-order, open-loop BPF. By adding series resonant circuits to the open ends of the resonator, we can create two resonant modes from the even and odd modes. One pair of the even and odd modes constitutes the upper passband, while the other pair constitutes the lower passband. By adding another series resonant circuit to the open-loop resonator, we can control the bandwidth of either the upper passband or the lower passband. We can replace the series resonant circuits with simple microstrip line resonators. A dual-band BPF working at both Wi-Fi bands (2.4 GHz and 5.8 GHz bands is designed based on the proposed method and is tested. The measured and simulated results show excellent agreement.
Directory of Open Access Journals (Sweden)
Guanquan Liang
2011-12-01
Full Text Available A prototype of planar silicon photonic structure is designed and simulated to provide narrow resonant line-width (∼2 nm in a wide photonic band gap (∼210 nm with broad tunable resonant wavelength range (∼100 nm around the optical communication wavelength 1550 nm. This prototype is based on the combination of two modified basic photonic structures, i.e. a split tapered photonic crystal micro-cavity embedded in a photonic wire waveguide, and a slot waveguide with narrowed slabs. This prototype is then further integrated with a MEMS (microelectromechanical systems based electrostatic comb actuator to achieve “coarse tune” and “fine tune” at the same time for wide range and narrow-band filtering and modulating. It also provides a wide range tunability to achieve the designed resonance even fabrication imperfection occurs.
Ferdjallah, M; Barr, R E
1994-06-01
This paper investigates adaptive digital notch filters for the elimination of powerline noise from biomedical signals. Since the distribution of the frequency variation of the powerline noise may or may not be centered at 60 Hz, three different adaptive digital notch filters are considered. For the first case, an adaptive FIR second-order digital notch filter is designed to track the center frequency variation. For the second case, the zeroes of an adaptive IIR second-order digital notch filter are fixed on the unit circle and the poles are adapted to find an optimum bandwidth to eliminate the noise to a pre-defined attenuation level. In the third case, both the poles and zeroes of the adaptive IIR second-order filter are adapted to track the center frequency variation within an optimum bandwidth. The adaptive process is considerably simplified by designing the notch filters by pole-zero placement on the unit circle using some suggested rules. A constrained least mean-squared (CLMS) algorithm is used for the adaptive process. To evaluate their performance, the three adaptive notch filters are applied to a powerline noise sample and to a noisy EEG as an illustration of a biomedical signal.
Hendrix, Charles D.; Vijaya Kumar, B. V. K.
1994-06-01
Correlation filters with three transmittance levels (+1, 0, and -1) are of interest in optical pattern recognition because they can be implemented on available spatial light modulators and because the zero level allows us to include a region of support (ROS). The ROS can provide additional control over the filter's noise tolerance and peak sharpness. A new algorithm based on optimizing a compromise average performance measure (CAPM) is proposed for designing three-level composite filters. The performance of this algorithm is compared to other three-level composite filter designs using a common image database and using figures of merit such as the Fisher ratio, error rate, and light efficiency. It is shown that the CAPM algorithm yields better results.
Building of scientific information system for sustainable development of BNCT in Bulgaria
International Nuclear Information System (INIS)
Mitev, M.; Ilieva, K.; Apostolov, T.
2009-01-01
Building a boron neutron capture therapy (BNCT) facility is foreseen within the reconstruction of the Research Reactor IRT (IRT) of the Institute for Nuclear Research and Nuclear Energy of the Bulgaria Academy of Sciences (INRNE). The development of BNCT at IRT plays a very significant role in the plan for sustainable application of the reactor. A centralized scientific information system on BNCT is being built at the INRNE with the purpose to collect and sort new information as knowledge accumulated during more than thirty years history of BNCT. This BNCT information system will help the creation and consolidation of a well informed and interconnected interdisciplinary team of physicists, chemists, biologists, and radio-oncologists for establishing BNCT cancer treatment in Bulgaria. It will strengthen more intensive development of the national network as well as its enlargement to the Balkan region countries. Furthermore, to acquaint the public at large with the opportunity for BNCT cancer treatment will be addressed. Human, social, and economics results due to BNCT for many patients from Balkan region are expected.
PBF/BNCT [power burst facility/boron neutron capture therapy] program for cancer treatment
International Nuclear Information System (INIS)
Dorn, R.V. III.
1989-06-01
Highlights of the PBF/BNCT Program during June include progress within the areas of gross boron analysis in tissue, blood, and urine; analytical methodologies development for BSH (sodium borocaptate) purity determination; boron microscopic (subcellular) analytical development; noninvasive boron quantification determination; dosimetry; and analytical radiation transport and interaction modeling for BNCT
Follow up of glioblastoma patients treated with BNCT using spectroscopic imaging
International Nuclear Information System (INIS)
Kankaanranta, L.; Haekkinen, A.M.; Kivisaari, L.; Lundbom, N.; Joensuu, H.; Seppaelae, T.
2000-01-01
The aim of the study was to investigate the metabolite changes of BPA-mediated BNCT on glioblastoma multiforme (GBM) and on brain white matter with proton magnetic spectroscopic imaging ( 1 H-MRSI). Four glioblastoma patients treated with BNCT were been examined with both MRI and 1 H-MRSI before BNCT and at 3-month intervals following BNCT. We found no change in the choline (Cho) of the tumors of 2 patients 3 months after BNCT, but at 6 months the choline increased in agreement with clinically observed progression of glioblastomas. No N-acetylaspartate (NAA) changes were found in the normal appearing white matter in 3 patients. Unexpectedly, choline changes were seen in both ipsi- and contralateral white matter regions. The small number of patients studied prevents making firm conclusions, but 1 H-MRSI may be a useful method in follow-up of patients treated with BNCT and deserves further study. Presence of only minimal NAA changes in some patients treated with BNCT is intriguing, and may suggest absence of marked neuronal damage within the first 6 months following BNCT treatment when average brain doses <5.2 Gy (W) are used. (author)
M. G. Dosskey; S. Neelakantan; T. G. Mueller; T. Kellerman; M. J. Helmers; E. Rienzi
2015-01-01
Spatially nonuniform runoif reduces the water qua1iry perfortnance of constant-Â width filter strips. A geographic inlormation system (Gls)-based tool was developedÂ and tested that ernploys terrain analysis to account lor spatially nonuniform runoffand produceÂ more ellbctive filter strip designs.The computer program,AgBufTerBuilder, runs withÂ ATcGIS versions 10.0 and 10...
Design of HEPA-filters above autoclaves and freeze-dryers.
Ljungqvist, B; Reinmüller, B
1998-01-01
In pharmaceutical manufacturing some processes and process equipment cause temperature differences relative to the surrounding air, e.g. sterilisation and freeze-drying processes. Generally there is a temperature difference when a door to such equipment is opened. This can cause a flow of room air through the opening, creating a contamination risk, especially when manual handling of material is performed in this area. To minimize this risk, a HEPA-filter unit should be installed above the opening to provide clean air and protect the opening. The airflow needed through the HEPA-filters depends mainly on the temperature difference between the chamber and the room and the size of the opening. The flow of clean air should be greater than that of the theoretically calculated flow in order to minimize contamination hazards. In this paper the theoretical relations are discussed and design criteria are presented in a simplified form with graphical representations. Results from a case study are described and the experimentally estimated air-flow values are compared with the theoretically calculated values.
Optimal IIR filter design using Gravitational Search Algorithm with Wavelet Mutation
Directory of Open Access Journals (Sweden)
S.K. Saha
2015-01-01
Full Text Available This paper presents a global heuristic search optimization technique, which is a hybridized version of the Gravitational Search Algorithm (GSA and Wavelet Mutation (WM strategy. Thus, the Gravitational Search Algorithm with Wavelet Mutation (GSAWM was adopted for the design of an 8th-order infinite impulse response (IIR filter. GSA is based on the interaction of masses situated in a small isolated world guided by the approximation of Newtonian’s laws of gravity and motion. Each mass is represented by four parameters, namely, position, active, passive and inertia mass. The position of the heaviest mass gives the near optimal solution. For better exploitation in multidimensional search spaces, the WM strategy is applied to randomly selected particles that enhance the capability of GSA for finding better near optimal solutions. An extensive simulation study of low-pass (LP, high-pass (HP, band-pass (BP and band-stop (BS IIR filters unleashes the potential of GSAWM in achieving better cut-off frequency sharpness, smaller pass band and stop band ripples, smaller transition width and higher stop band attenuation with assured stability.
Simultaneous design of FIR filter banks and spatial patterns for EEG signal classification.
Higashi, Hiroshi; Tanaka, Toshihisa
2013-04-01
The spatial weights for electrodes called common spatial pattern (CSP) are known to be effective in EEG signal classification for motor imagery-based brain-computer interface (MI-BCI). To achieve accurate classification in CSP, it is necessary to find frequency bands that relate to brain activities associated with BCI tasks. Several methods that determine such a set of frequency bands have been proposed. However, the existing methods cannot find the multiple frequency bands by using only learning data. To address this problem, we propose discriminative filter bank CSP (DFBCSP) that designs finite impulse response filters and the associated spatial weights by optimizing an objective function which is a natural extension of that of CSP. The optimization is conducted by sequentially and alternatively solving subproblems into which the original problem is divided. By experiments, it is shown that DFBCSP can effectively extract discriminative features for MI-BCI. Moreover, experimental results exhibit that DFBCSP can detect and extract the bands related to brain activities of motor imagery.
Chen, Xing; Cui, Dafu; Chen, Jian
2009-09-01
Since most clinical assays are performed on cell-free serum or plasma, micro-analytical systems for blood tests require integrated on-chip microfluidics for the isolation of plasma or serum from crude blood samples. In this paper, we present a crossflow filtration method using novel silicon nano-filters for plasma separation. The microfluidic chip is made of a silicon substrate containing micropillar arrays, feed channels, side channels and nano-gap structures, sealed with a PDMS-glass compound cover. The design of the silicon filtration structures were optimized using numerical analysis and the optimal MEMS fabrication procedures were obtained. The filtration structures including nano-filters were characterized using SEM and subsequently used to isolate plasma from whole blood in a continuous manner. Compared with micro-gap structures in silicon microfluidic channels, the nano-gap structures have been used to separate plasma from whole blood samples with higher selectivity, where a maximum plasma selectivity of 97.7% has been obtained. Common problems of clogging and jamming in filtration applications have seldom been noticed in our device. The presented microfluidic filtration device for plasma isolation could be integrated into microTAS for point-of-care diagnostics in the near future.
Frequency Spectrum Based Low-Area Low-Power Parallel FIR Filter Design
Directory of Open Access Journals (Sweden)
Jin-Gyun Chung
2002-09-01
Full Text Available Parallel (or block FIR digital filters can be used either for high-speed or low-power (with reduced supply voltage applications. Traditional parallel filter implementations cause linear increase in the hardware cost with respect to the block size. Recently, an efficient parallel FIR filter implementation technique requiring a less-than linear increase in the hardware cost was proposed. This paper makes two contributions. First, the filter spectrum characteristics are exploited to select the best fast filter structures. Second, a novel block filter quantization algorithm is introduced. Using filter benchmarks, it is shown that the use of the appropriate fast FIR filter structures and the proposed quantization scheme can result in reduction in the number of binary adders up to 20%.
Synthesis and in-vivo detection of boronated compounds for use in BNCT
Energy Technology Data Exchange (ETDEWEB)
Kabalka, G.W.
1992-01-01
The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The UT-DOE program is unique in that it has access to both state-of-the-art whole-body and microscopy MRI instruments.
Power Efficient Design of Parallel/Serial FIR Filters in RNS
DEFF Research Database (Denmark)
Petricca, Massimo; Albicocco, Pietro; Cardarilli, Gian Carlo
2012-01-01
filter potentially disadvantageous with respect to filters implemented in the conventional number systems. In this work, we show a number of solutions which demonstrate that the power efficiency of RNS FIR filters implemented serially is maintained in ASIC technology, while in modern FPGA technology RNS...
A design aid for sizing filter strips using buffer area ratio
M.G. Dosskey; M.J. Helmers; D.E. Eisenhauer
2011-01-01
Nonuniform field runoff can reduce the effectiveness of filter strips that are a uniform size along a field margin. Effectiveness can be improved by placing more filter strip where the runoff load is greater and less where the load is smaller. A modeling analysis was conducted of the relationship between pollutant trapping efficiency and the ratio of filter strip area...
Microwave digestion techniques applied to determination of boron by ICP-AES in BNCT program
International Nuclear Information System (INIS)
Farias, Silvia S.; Di Santo, Norberto R.; Garavaglia, Ricardo N.; Pucci, Gladys N.; Batistoni, Daniel A.; Schwint, Amanda E.
1999-01-01
Recently, boron neutron capture therapy (BNCT) has merged as an interesting option for the treatment of some kind of tumors where established therapies show no success. A molecular boronated species, enriched in 10 B is administrated to the subject; it localizes in malignant tissues depending the kind of tumor and localization. Therefore, a very important fact in BNCT research is the detection of boron at trace or ultra trace levels precisely and accurately. This is extremely necessary as boronated species do localize in tumoral tissue and also localize in liver, kidney, spleen, skin, membranes. By this way, before testing a boronated species, it is mandatory to determine its biodistribution in a statistically meaning population, that is related with managing of a great number of samples. In the other hand, it is necessary to exactly predict when to begin the irradiation and to determine the magnitude of radiation to obtain the desired radiological dose for a specified mean boron concentration. This involves the determination of boron in whole blood, which is related with boron concentration in the tumor object of treatment. The methodology selected for the analysis of boron in whole blood and tissues must join certain characteristics: it must not be dependant of the chemical form of boron, it has to be fast and capable to determine boron accurately and precisely in a wide range of concentrations. The design and validation of experimental models involving animals in BNCT studies and the determination of boron in blood of animals and subjects upon treatment require reliable analytical procedures to determine boron quantitatively in those biologic materials. Inductively coupled plasma-atomic emission spectrometry (ICP-AES) using pneumatic nebulization is one of the most promising methods for boron analysis, but the sample must be liquid and have low solid concentration. In our case, biological tissues and blood, it is mandatory to mineralize and/or dilute samples
Event-Triggered Fault Detection Filter Design for a Continuous-Time Networked Control System.
Wang, Yu-Long; Shi, Peng; Lim, Cheng-Chew; Liu, Yuan
2016-12-01
This paper studies the problem of event-triggered fault detection filter (FDF) and controller coordinated design for a continuous-time networked control system (NCS) with biased sensor faults. By considering sensor-to-FDF network-induced delays and packet dropouts, which do not impose a constraint on the event-triggering mechanism, and proposing the simultaneous network bandwidth utilization ratio and fault occurrence probability-based event-triggering mechanism, a new closed-loop model for the considered NCS is established. Based on the established model, the event-triggered H ∞ performance analysis, and FDF and controller coordinated design are presented. The combined mutually exclusive distribution and Wirtinger-based integral inequality approach is proposed for the first time to deal with integral inequalities for products of vectors. This approach is proved to be less conservative than the existing Wirtinger-based integral inequality approach. The designed FDF and controller can guarantee the sensitivity of the residual signal to faults and the robustness of the NCS to external disturbances. The simulation results verify the effectiveness of the proposed event-triggering mechanism, and the FDF and controller coordinated design.
Design of Super Narrowband DWDM Filters Based on the Effect of Spectral Splitting
Energy Technology Data Exchange (ETDEWEB)
Huang, C Q; Chen, M [College of Physics and Electronics, Hunan Institute of Science and Technology, Yueyang 414006 (China); Liu, J; Wan, Z M; Luo, Z M [College of Information and Communication Engineering, Hunan Institute of Science and Technology, Yueyang 414006 (China); Tian, P, E-mail: namecqh@yahoo.com.cn [College of Optoelectronic Science and Engineering, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074 (China)
2011-02-01
A novel approach is proposed to design super narrowband DWDM Filters consisting of multiple quantum wells (MQWs) by employing photonic crystals. Numerical investigations prove that the closed-cavity MQWs are more suitable for DWDM systems compared with the open-cavity MQWs. It is shown that different confined states could emerge from photonic band gap, which can be used as high-frequency carriers one-to-one. It is also found that these proposed MQWs could split the single spectral lines into multiples based on the effect of spectral splitting, and the number of the splitting is just equal to the number of the wells. In this way, the density of carriers can be increased multiplicatively in the same wave band, and thus the spectral efficiency can be improved multiplicatively. These results provide the prospects of channel density maximization and effective bandwidth optimization for optical communication.
IMC-PID-fractional-order-filter controllers design for integer order systems.
Maâmar, Bettayeb; Rachid, Mansouri
2014-09-01
One of the reasons of the great success of standard PID controllers is the presence of simple tuning rules, of the automatic tuning feature and of tables that simplify significantly their design. For the fractional order case, some tuning rules have been proposed in the literature. However, they are not general because they are valid only for some model cases. In this paper, a new approach is investigated. The fractional property is not especially imposed by the controller structure but by the closed loop reference model. The resulting controller is fractional but it has a very interesting structure for its implementation. Indeed, the controller can be decomposed into two transfer functions: an integer transfer function which is generally an integer PID controller and a simple fractional filter. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.
A Comparison of FPGA and GPGPU Designs for Bayesian Occupancy Filters
Directory of Open Access Journals (Sweden)
Luis Medina
2017-11-01
Full Text Available Grid-based perception techniques in the automotive sector based on fusing information from different sensors and their robust perceptions of the environment are proliferating in the industry. However, one of the main drawbacks of these techniques is the traditionally prohibitive, high computing performance that is required for embedded automotive systems. In this work, the capabilities of new computing architectures that embed these algorithms are assessed in a real car. The paper compares two ad hoc optimized designs of the Bayesian Occupancy Filter; one for General Purpose Graphics Processing Unit (GPGPU and the other for Field-Programmable Gate Array (FPGA. The resulting implementations are compared in terms of development effort, accuracy and performance, using datasets from a realistic simulator and from a real automated vehicle.
Sequencing of Dust Filter Production Process Using Design Structure Matrix (DSM)
Sari, R. M.; Matondang, A. R.; Syahputri, K.; Anizar; Siregar, I.; Rizkya, I.; Ursula, C.
2018-01-01
Metal casting company produces machinery spare part for manufactures. One of the product produced is dust filter. Most of palm oil mill used this product. Since it is used in most of palm oil mill, company often have problems to address this product. One of problem is the disordered of production process. It carried out by the job sequencing. The important job that should be solved first, least implement, while less important job and could be completed later, implemented first. Design Structure Matrix (DSM) used to analyse and determine priorities in the production process. DSM analysis is sort of production process through dependency sequencing. The result of dependency sequences shows the sequence process according to the inter-process linkage considering before and after activities. Finally, it demonstrates their activities to the coupled activities for metal smelting, refining, grinding, cutting container castings, metal expenditure of molds, metal casting, coating processes, and manufacture of molds of sand.
Suman, S.; Kumar, A.; Singh, G. K.
2015-04-01
In this paper, a new method for the design of variable bandwidth linear-phase finite impulse response filters using Bernstein polynomial Multiwavelets is proposed. In this method, approximation has been achieved by linearly combining the fixed coefficient linear phase filters with Bernstein multiwavelets, which are used to tune bandwidth of the filter. Optimisation has been achieved by minimising the mean square error between the desired and actual filter response which leads to a system of linear equations. The matrix elements can be expressed in form of Toeplitz-plus-Hankel matrix, which reduces the computational complexity. The simulation results illustrate significant improvement in errors in passband (ep), and stopband (es) as compared to earlier published work.
A Design of Finite Memory Residual Generation Filter for Sensor Fault Detection
Kim, Pyung Soo
2017-04-01
In the current paper, a residual generation filter with finite memory structure is proposed for sensor fault detection. The proposed finite memory residual generation filter provides the residual by real-time filtering of fault vector using only the most recent finite measurements and inputs on the window. It is shown that the residual given by the proposed residual generation filter provides the exact fault for noisefree systems. The proposed residual generation filter is specified to the digital filter structure for the amenability to hardware implementation. Finally, to illustrate the capability of the proposed residual generation filter, extensive simulations are performed for the discretized DC motor system with two types of sensor faults, incipient soft bias-type fault and abrupt bias-type fault. In particular, according to diverse noise levels and windows lengths, meaningful simulation results are given for the abrupt bias-type fault.
International Nuclear Information System (INIS)
Lee, Seunguk; Park, Minchan; Lee, Jaekeun
2014-01-01
In the U. S., the number of HEPA filters, which are located in the HVAC system of nuclear power plants, generated as wastes is annually 31,055, and tremendous economic/social costs are incurred to deal with them. Thus, it is needed to develop the metal fiber filter that can be reused and has performance equal to the HEPA level to replace the glass fiber HEPA filter. This study, to draw the optimal design factors of the metal fiber filter for removing radioactive aerosol, analyzed the design condition by reflecting the actual temperature and pressure condition that can be generated in the nuclear HVAC system to the particle collection mechanism by single fiber. As a result of performing modeling for the radioactive aerosol particle collection efficiency and the pressure drop of the filter made up with single metal fiber. It was analyzed that when a diameter of the metal fiber is less than 4 μm, thickness more than 1 mm, solidity more than 0.2, and face velocity less than 5 cm, it shows more than 99.97% particle collection efficiency, which is equal to the HEPA level. Because generally as the particle collection efficiency gets higher, the pressure drop gets bigger, it is judged that the filter design factors should be optimized to satisfy the design condition for the HVAC system. It is also judged that, in the future, an additional verification should be conducted through a comparison of the test results of the filter particle collection efficiency and the pressure drop in the condition of actual temperature and pressure, and the modeling results of this study
International Nuclear Information System (INIS)
Zhang, Bin; E, Jiaqiang; Gong, Jinke; Yuan, Wenhua; Zuo, Wei; Li, Yu; Fu, Jun
2016-01-01
Highlights: • The multidisciplinary design optimization (MDO) for the DPF is presented. • MDO model and multi-objective functions of the DPF are established. • The optimal design parameters are obtained and DPF’s performances are improved. • The optimized results are verified by experiments. • The composite regeneration process of the optimized DPF allows a higher energy saving. - Abstract: In our previous works, the diesel particulate filter (DPF) using a new composite regeneration mode by coupling microwave and ceria-manganese base catalysts is verified as an effective way to reduce the particulate matter emission of the diesel engine. In order to improve the overall performance of this DPF, its multidisciplinary design optimization (MDO) model is established based on objective functions such as pressure drop, regeneration performance, microwave energy consumption, and thermal shock resistance. Then, the DPF is optimized by using MDO method based on adaptive mutative scale chaos optimization algorithm. The optimization results show that with the help of MDO, DPF’s pressure drop is decreased by 14.5%, regeneration efficiency is increased by 17.3%, microwave energy consumption is decreased by 17.6%, and thermal deformation is decreased by 25.3%. The optimization results are also verified by experiments, and the experimental results indicate that the optimized DPF has larger filtration efficiency, better emission performance and regeneration performance, smaller pressure drop, lower wall temperature and temperature gradient, and lower microwave energy consumption.
Optimal Design of the Adaptive Normalized Matched Filter Detector using Regularized Tyler Estimators
Kammoun, Abla
2017-10-25
This article addresses improvements on the design of the adaptive normalized matched filter (ANMF) for radar detection. It is well-acknowledged that the estimation of the noise-clutter covariance matrix is a fundamental step in adaptive radar detection. In this paper, we consider regularized estimation methods which force by construction the eigenvalues of the covariance estimates to be greater than a positive regularization parameter ρ. This makes them more suitable for high dimensional problems with a limited number of secondary data samples than traditional sample covariance estimates. The motivation behind this work is to understand the effect and properly set the value of ρthat improves estimate conditioning while maintaining a low estimation bias. More specifically, we consider the design of the ANMF detector for two kinds of regularized estimators, namely the regularized sample covariance matrix (RSCM), the regularized Tyler estimator (RTE). The rationale behind this choice is that the RTE is efficient in mitigating the degradation caused by the presence of impulsive noises while inducing little loss when the noise is Gaussian. Based on asymptotic results brought by recent tools from random matrix theory, we propose a design for the regularization parameter that maximizes the asymptotic detection probability under constant asymptotic false alarm rates. Provided Simulations support the efficiency of the proposed method, illustrating its gain over conventional settings of the regularization parameter.
Design of a robust thin-film interference filter for erbium-doped fiber amplifier gain equalization.
Verly, Pierre G
2002-06-01
Gain-flattening filters (GFFs) are key wavelength division multiplexing components in fiber-optics telecommunications. Challenging issues in the design of thin-film GFFs were recently the subject of a contest organized at the 2001 Conference on Optical Interference Coatings. The interest and main difficulty of the proposed problem was to minimize the sensitivity of a GFF to simulated fabrication errors. A high-yield solution and its design philosophy are described. The approach used to control the filter robustness is explained and illustrated by numerical results.
Neutron generator for BNCT based on high current ECR ion source with gyrotron plasma heating.
Skalyga, V; Izotov, I; Golubev, S; Razin, S; Sidorov, A; Maslennikova, A; Volovecky, A; Kalvas, T; Koivisto, H; Tarvainen, O
2015-12-01
BNCT development nowadays is constrained by a progress in neutron sources design. Creation of a cheap and compact intense neutron source would significantly simplify trial treatments avoiding use of expensive and complicated nuclear reactors and accelerators. D-D or D-T neutron generator is one of alternative types of such sources for. A so-called high current quasi-gasdynamic ECR ion source with plasma heating by millimeter wave gyrotron radiation is suggested to be used in a scheme of D-D neutron generator in the present work. Ion source of that type was developed in the Institute of Applied Physics of Russian Academy of Sciences (Nizhny Novgorod, Russia). It can produce deuteron ion beams with current density up to 700-800 mA/cm(2). Generation of the neutron flux with density at the level of 7-8·10(10) s(-1) cm(-2) at the target surface could be obtained in case of TiD2 target bombardment with deuteron beam accelerated to 100 keV. Estimations show that it is enough for formation of epithermal neutron flux with density higher than 10(9) s(-1) cm(-2) suitable for BNCT. Important advantage of described approach is absence of Tritium in the scheme. First experiments performed in pulsed regime with 300 mA, 45 kV deuteron beam directed to D2O target demonstrated 10(9) s(-1) neutron flux. This value corresponds to theoretical estimations and proofs prospects of neutron generator development based on high current quasi-gasdynamic ECR ion source. Copyright © 2015 Elsevier Ltd. All rights reserved.
Impact of a flattening filter free linear accelerator on structural shielding design
International Nuclear Information System (INIS)
Jank, Julia; Kragl, Gabriele; Georg, Dietmar; Medical University of Vienna
2014-01-01
Purpose: The present study aimed to assess the effects of a flattening filter free medical accelerator on structural shielding demands of a treatment vault of a medical linear accelerator. We tried to answer the question, to what extent the required thickness of the shielding barriers can be reduced if instead of the standard flattened photon beams unflattened ones are used. Material and Methods: We chose both an experimental as well as a theoretical approach. On the one hand we measured photon dose rates at protected places outside the treatment room and compared the obtained results for flattened and unflattened beams. On the other hand we complied with international guidelines for adequate treatment vault design and calculated the shielding barriers according to the therein given specifications. Measurements were performed with an Elekta Precise trademark linac providing nominal photon energies of 6 and 10 MV. This machine underwent already earlier some modifications in order to be able to operate both with and without a flattening filter. Photon dose rates were measured with a LB133-1 dose rate meter manufactured by Berthold. To calculate the thickness of shielding barriers we referred to the Austrian standard OeNORM S 5216 and to the US American NCRP Report No. 151. Results: We determined a substantial photon dose rate reduction for all measurement points and photon energies. For unflattened 6 MV beams a reduction factor ranging from 1.4 to 1.8 was identified. The corresponding values for unflattened 10 MV beams were 2.1 and 3.2. The performed shielding calculations indicated the same tendency: For all relevant radiation components we found a reduction in shielding thickness when unflattened beams were used. The required thickness of primary barriers was reduced up to 8.0%, the thickness of secondary barriers up to 11.4%, respectively. Conclusions: For an adequate dimensioning of treatment vault shielding barriers it is by no means irrelevant if the
Directory of Open Access Journals (Sweden)
Deepa Yagain
2014-01-01
Full Text Available Retiming is a transformation which can be applied to digital filter blocks that can increase the clock frequency. This transformation requires computation of critical path and shortest path at various stages. In literature, this problem is addressed at multiple points. However, very little attention is given to path solver blocks in retiming transformation algorithm which takes up most of the computation time. In this paper, we address the problem of optimizing the speed of path solvers in retiming transformation by introducing high level synthesis of path solver algorithm architectures on FPGA and a computer aided design tool. Filters have their combination blocks as adders, multipliers, and delay elements. Avoiding costly multipliers is very much needed for filter hardware implementation. This can be achieved efficiently by using multiplierless MCM technique. In the present work, retiming which is a high level synthesis optimization method is combined with multiplierless filter implementations using MCM algorithm. It is seen that retiming multiplierless designs gives better performance in terms of operating frequency. This paper also compares various retiming techniques for multiplierless digital filter design with respect to VLSI performance metrics such as area, speed, and power.
Fatal carotid blowout syndrome after BNCT for head and neck cancers
International Nuclear Information System (INIS)
Aihara, T.; Hiratsuka, J.; Ishikawa, H.; Kumada, H.; Ohnishi, K.; Kamitani, N.; Suzuki, M.; Sakurai, H.; Harada, T.
2015-01-01
Boron neutron capture therapy (BNCT) is high linear energy transfer (LET) radiation and tumor-selective radiation that does not cause serious damage to the surrounding normal tissues. BNCT might be effective and safe in patients with inoperable, locally advanced head and neck cancers, even those that recur at previously irradiated sites. However, carotid blowout syndrome (CBS) is a lethal complication resulting from malignant invasion of the carotid artery (CA); thus, the risk of CBS should be carefully assessed in patients with risk factors for CBS after BNCT. Thirty-three patients in our institution who underwent BNCT were analyzed. Two patients developed CBS and experienced widespread skin invasion and recurrence close to the carotid artery after irradiation. Careful attention should be paid to the occurrence of CBS if the tumor is located adjacent to the carotid artery. The presence of skin invasion from recurrent lesions after irradiation is an ominous sign of CBS onset and lethal consequences. - Highlights: • This study is fatal carotid blowout syndrome after BNCT for head and neck cancers. • Thirty-three patients in our institution who underwent BNCT were analyzed. • Two patients (2/33) developed CBS. • The presence of skin invasion from recurrent lesions after irradiation is an ominous sign of CBS. • We must be aware of these signs to perform BNCT safely.
Study of spectral response of a neutron filter. Design of a method to adjust spectra
International Nuclear Information System (INIS)
Colomb-Dolci, F.
1999-02-01
The first part of this thesis describes an experimental method which intends to determine a neutron spectrum in the epithermal range [1 eV -10 keV]. Based on measurements of reaction rates provided by activation foils, it gives flux level in each energy range corresponding to each probe. This method can be used in any reactor location or in a neutron beam. It can determine scepter on eight energy groups, five groups in the epithermal range. The second part of this thesis presents a study of an epithermal neutron beam design, in the frame of Neutron Capture Therapy. A beam tube was specially built to test filters made up of different materials. Its geometry was designed to favour epithermal neutron crossing and to cut thermal and fast neutrons. A code scheme was validated to simulate the device response with a Monte Carlo code. Measurements were made at ISIS reactor and experimental spectra were compared to calculated ones. This validated code scheme was used to simulate different materials usable as shields in the tube. A study of these shields is presented at the end of this thesis. (author)
DEFF Research Database (Denmark)
Akhavan, Ali; Mohammadi, Hamid Reza; Guerrero, Josep M.
2018-01-01
The quality of injected current in multi-paralleled grid-connected inverters is a matter of concern. The current controlled grid-connected inverters with LCL filter are widely used in the distributed generation (DG) systems due to their fast dynamic response and better power features. However......, designing a reliable control system for grid-connected inverters with LCL filter is complicated. Firstly, overcoming to system resonances due to LCL filters is a challenging task, intrinsically. This could become worse as number of paralleled grid-connected inverters increased. In order to deal...... with resonances in the system, damping methods such as passive or active damping is necessary. Secondly and perhaps more importantly, paralleled grid-connected inverters in a microgrid are coupled due to grid impedance. Generally, the coupling effect is not taken into account when designing the control systems...
Energy Technology Data Exchange (ETDEWEB)
Chadha, M. [Beth Israel Medical Center, NY (United States). Dept. of Radiation Oncology; Coderre, J.A.; Chanana, A.D. [Brookhaven National Lab., Upton, NY (United States)] [and others
1996-12-31
A phase I/II trial delivering a single fraction of BNCT using p-Boronophenylalanine-Fructose and epithermal neutrons at the the Brookhaven Medical Research Reactor was initiated in September 1994. The primary endpiont of the study was to evaluate the feasibility and safety of a given BNCT dose. The clinical outcome of the disease was a secondary endpoint of the study. The objective of this paper is to evaluate the correlation of the clinical outcome of patients to the estimated radiation dose from BNCT.
International Nuclear Information System (INIS)
Chadha, M.
1996-01-01
A phase I/II trial delivering a single fraction of BNCT using p-Boronophenylalanine-Fructose and epithermal neutrons at the the Brookhaven Medical Research Reactor was initiated in September 1994. The primary endpiont of the study was to evaluate the feasibility and safety of a given BNCT dose. The clinical outcome of the disease was a secondary endpoint of the study. The objective of this paper is to evaluate the correlation of the clinical outcome of patients to the estimated radiation dose from BNCT
Porter, Lon A., Jr.; Chapman, Cole A.; Alaniz, Jacob A.
2017-01-01
In this work, a versatile and user-friendly selection of stereolithography (STL) files and computer-aided design (CAD) models are shared to assist educators and students in the production of simple and inexpensive 3D printed filter fluorometer instruments. These devices are effective resources for supporting active learners in the exploration of…
LC Filter Design for Wide Band Gap Device Based Adjustable Speed Drives
DEFF Research Database (Denmark)
Vadstrup, Casper; Wang, Xiongfei; Blaabjerg, Frede
2014-01-01
the LC filter with a higher cut off frequency and without damping resistors. The selection of inductance and capacitance is chosen based on capacitor voltage ripple and current ripple. The filter adds a base load to the inverter, which increases the inverter losses. It is shown how the modulation index...
Filter designs based on coupled transmission line model for double split ring resonators
DEFF Research Database (Denmark)
Yan, Lei; Tang, Meng; Krozer, Viktor
2012-01-01
. According to the filter specifications, the low‐pass prototype parameters are used to calculate the required coupling coefficients between coupled DSRRs. The corresponding coupling coefficients are realized by using asymmetric coupled multi‐conductors networks. The proposed filter synthesis approach...
Zhang, Hao; Kang, Wei; Wu, Wen
2017-12-01
In this paper, a miniaturized diplexer designed with two novel one-third-mode substrate integrated resonator (OTMSIR) filters has been presented. The one-third triangular resonator cavity with two transmission zeros (TZs) and two transmission poles is investigated. TZs are implemented by taking cross couplings of lower order modes in this design. The diplexer is then obtained by integrating two different sizes of OTMSIR filters with a common T-junction structure. A X-band diplexer operating at 10 GHz and 11.5 GHz is designed on a substrate with a dielectric constant of 3.55 to verify the above design concept. This novel structure features more compact size, better transmission performance, higher out of band rejection and easier integration compared with other circuits. A good agreement is obtained between the simulations and the measured results.
Energy Technology Data Exchange (ETDEWEB)
Slim, J. [Institute of High-Frequency Technology, RWTH Aachen University, 52074 Aachen (Germany); Gebel, R. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); Heberling, D. [Institute of High-Frequency Technology, RWTH Aachen University, 52074 Aachen (Germany); JARA-FAME (Forces and Matter Experiments), Forschungszentrum Jülich and RWTH Aachen University, 52056 Aachen (Germany); Hinder, F. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); III. Physikalisches Institut B, RWTH Aachen University, 52074 Aachen (Germany); Hölscher, D. [Institute of High-Frequency Technology, RWTH Aachen University, 52074 Aachen (Germany); Lehrach, A. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); JARA-FAME (Forces and Matter Experiments), Forschungszentrum Jülich and RWTH Aachen University, 52056 Aachen (Germany); III. Physikalisches Institut B, RWTH Aachen University, 52074 Aachen (Germany); Lorentz, B. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); Mey, S. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); III. Physikalisches Institut B, RWTH Aachen University, 52074 Aachen (Germany); Nass, A.; Rathmann, F. [Institute of Nuclear Physics (IKP), Forschungszentrum Jülich, 52428 Jülich (Germany); and others
2016-08-21
The conventional Wien filter is a device with orthogonal static magnetic and electric fields, often used for velocity separation of charged particles. Here we describe the electromagnetic design calculations for a novel waveguide RF Wien filter that will be employed to solely manipulate the spins of protons or deuterons at frequencies of about 0.1–2 MHz at the COoler SYnchrotron COSY at Jülich. The device will be used in a future experiment that aims at measuring the proton and deuteron electric dipole moments, which are expected to be very small. Their determination, however, would have a huge impact on our understanding of the universe.
Slim, J.; Gebel, R.; Heberling, D.; Hinder, F.; Hölscher, D.; Lehrach, A.; Lorentz, B.; Mey, S.; Nass, A.; Rathmann, F.; Reifferscheidt, L.; Soltner, H.; Straatmann, H.; Trinkel, F.; Wolters, J.
2016-08-01
The conventional Wien filter is a device with orthogonal static magnetic and electric fields, often used for velocity separation of charged particles. Here we describe the electromagnetic design calculations for a novel waveguide RF Wien filter that will be employed to solely manipulate the spins of protons or deuterons at frequencies of about 0.1-2 MHz at the COoler SYnchrotron COSY at Jülich. The device will be used in a future experiment that aims at measuring the proton and deuteron electric dipole moments, which are expected to be very small. Their determination, however, would have a huge impact on our understanding of the universe.
Slim, J.; Gebel, R.; Heberling, D.; Hinder, F.; Hölscher, D.; Lehrach, A.; Lorentz, B.; Mey, S.; Nass, A.; Rathmann, F.; Reifferscheidt, L.; Soltner, H.; Straatmann, H.; Trinkel, F.; Wolters, J.
2016-01-01
The conventional Wien filter is a device with orthogonal static magnetic and electric fields, often used for velocity separation of charged particles. Here we describe the electromagnetic design calculations for a novel waveguide RF Wien filter that will be employed to solely manipulate the spins of protons or deuterons at frequencies of about 0.1 to 2 MHz at the COoler SYnchrotron COSY at J\\"ulich. The device will be used in a future experiment that aims at measuring the proton and deuteron ...
Direct and Inverse Techniques of Guided-Mode Resonance Filters Designs
Tibuleac, Sorin; Magnusson, Robert; Maldonado, Theresa A.; Zuffada, Cinzia
1997-01-01
Guided-mode resonances arise in single or multilayer waveguides where one or more homogeneous layers are replaced by diffraction gratings (Fig. 1.) The diffractive element enables an electromagnetic wave incident on a waveguide grating to be coupled to the waveguide modes supportable by the structure in the absence of the modulation (i.e. the difference between the high and low dielectric constants of the grating) at specific values of the wavelength and incident angle. The periodic modulation of the guide makes the structure leaky, preventing sustained propagation of modes in the waveguide and coupling the waves out into the substrate and cover. As the wavelength is varied around resonance a rapid variation in the intensities of the external propagating waves occurs. By selecting a grating period small enough to eliminate the higher-order propagating waves, an increase in the zero-order intensities up to 100% can result. The pronounced frequency selectivity of guided-mode resonances in dielectric waveguide gratings can be applied to design high-efficiency reflection and transmission filters [1-3].
JY1 time scale: a new Kalman-filter time scale designed at NIST
International Nuclear Information System (INIS)
Yao, Jian; Parker, Thomas E; Levine, Judah
2017-01-01
We report on a new Kalman-filter hydrogen-maser time scale (i.e. JY1 time scale) designed at the National Institute of Standards and Technology (NIST). The JY1 time scale is composed of a few hydrogen masers and a commercial Cs clock. The Cs clock is used as a reference clock to ease operations with existing data. Unlike other time scales, the JY1 time scale uses three basic time-scale equations, instead of only one equation. Also, this time scale can detect a clock error (i.e. time error, frequency error, or frequency drift error) automatically. These features make the JY1 time scale stiff and less likely to be affected by an abnormal clock. Tests show that the JY1 time scale deviates from the UTC by less than ±5 ns for ∼100 d, when the time scale is initially aligned to the UTC and then is completely free running. Once the time scale is steered to a Cs fountain, it can maintain the time with little error even if the Cs fountain stops working for tens of days. This can be helpful when we do not have a continuously operated fountain or when the continuously operated fountain accidentally stops, or when optical clocks run occasionally. (paper)
Energy Technology Data Exchange (ETDEWEB)
Iwakura, M.; Tamaki, N. [Kobe Univ. (Japan). School of Medicine; Kondoh, H.; Mishima, Y. [Mishima Inst. for Dermatol. Res., Kobe, Hyogo (Japan); Hiratsuka, J. [Kawasaki Medical School, Dept. Radiation Oncol., Kurashiki, Okayama (Japan)
2000-10-01
Our success in eradicating melanoma by single BNCT with BPA led to the next urgent theme, i.e. application of such BNCT for currently uncurable melanoma metastasis in brain. In order to establish {sup 10}B-BPA-BNCT for melanoma in brain, we have investigated the pharmacokinetics of BPA which is most critical factor for successful BNCT, in melanotic and amelanotic and further tyrosinase gene-transfected amelanotic melanoma proliferating in brain having blood-brain-barrier, as compared to melanoma proliferating in skin. We have established three implanted models for melanoma in brain: 1) A1059 cells, amelanotic melanoma, 2) B16B15b cells, melanotic melanoma cells, highly metastatic to brain, and 3) TA1059 cells, with active melanogenesis induced by tyrosinase gene transfection. We would like to report the results of comparative analysis of the BPA uptake ability in these melanoma cells in both brain and skin. Based on these findings, we are further investigating to enhance {sup 10}B-BPA uptake by not only g-BNCT but also by additional melanogenesis upregulating cell modulation. (author)
International Nuclear Information System (INIS)
Iwakura, M.; Tamaki, N.; Hiratsuka, J.
2000-01-01
Our success in eradicating melanoma by single BNCT with BPA led to the next urgent theme, i.e. application of such BNCT for currently uncurable melanoma metastasis in brain. In order to establish 10 B-BPA-BNCT for melanoma in brain, we have investigated the pharmacokinetics of BPA which is most critical factor for successful BNCT, in melanotic and amelanotic and further tyrosinase gene-transfected amelanotic melanoma proliferating in brain having blood-brain-barrier, as compared to melanoma proliferating in skin. We have established three implanted models for melanoma in brain: 1) A1059 cells, amelanotic melanoma, 2) B16B15b cells, melanotic melanoma cells, highly metastatic to brain, and 3) TA1059 cells, with active melanogenesis induced by tyrosinase gene transfection. We would like to report the results of comparative analysis of the BPA uptake ability in these melanoma cells in both brain and skin. Based on these findings, we are further investigating to enhance 10 B-BPA uptake by not only g-BNCT but also by additional melanogenesis upregulating cell modulation. (author)
Directory of Open Access Journals (Sweden)
Guiju ZHANG
2015-11-01
Full Text Available Developments in micro and nanofabrication technologies have led a variety of grating waveguide structures (GWS being proposed and implemented in optics and laser application systems. A new design of multilayered nanostructure double-grating is described for reflection notch filter. Thin metal film and dielectric film are used and designed with one-dimensional composite gratings. The results calculated by rigorous coupled-wave analysis (RCWA present that the thin metal film between substrate and grating can produce significant attenuated reflections and efficiency in a broad reflected spectral range. The behavior of such a reflection filter is evaluated for refractive index sensing, which can be applied inside the integrated waveguide structure while succeeding cycles in measurement. The filter peaks are designed and obtained in a visible range with full width half maximum (FWHM of several nanometers to less than one nanometer. The multilayered structure shows a sensitivity of refractive index of 220nm/RIU as changing the surroundings. The reflection spectra are studied under different periods, depths and duty cycles. The passive structure and its characteristics can achieve practical applications in various fields, such as optical sensing, color filtering, Raman spectroscopy and laser technology.DOI: http://dx.doi.org/10.5755/j01.ms.21.4.9625
Design of a Low-Power Universal Gm-C Filter in Sub-Threshold Region
Directory of Open Access Journals (Sweden)
Mohammad Aghaei Jeshvaghani
2013-10-01
Full Text Available In this paper, a second order universal filter with the ability of electronically tuning central frequency (ω0 and quality factor (Q, based on the inverter as transconductance block which realizes multi-mode responses (voltage, current, transconductance, transresistance in sub-threshold region, is presented. Biasing transistors in sub-threshold region, reduces the power consumption of the proposed filter and the grounded capacitors are used to reduce the parasitic effects which is another advantage of the proposed filter circuit. Furthermore, low sensitivity of the performance of the proposed filter to the values of gmi , Ci is considered as another advantage of the proposed circuit. In addition, realizing the proposed filter based on the inverter circuit leads to a reduced value of layout area as well as power consumption. Finally, the proposed filter performance is simulated in HSPICE using 0.18 µm (LEVEL49 CMOS technology parameters. As it is shown in the paper, the proposed filter consumes only 64.69 nW power in a ±0.3V supply voltage.
Baeza, A; Salas, A; Guillén, J; Muñoz-Serrano, A; Ontalba-Salamanca, M Á; Jiménez-Ramos, M C
2017-01-01
The occurrence of naturally occurring radionuclides in drinking water can pose health hazards in some populations, especially taking into account that routine procedures in Drinking Water Treatment Plants (DWTPs) are normally unable to remove them efficiently from drinking water. In fact, these procedures are practically transparent to them, and in particular to radium. In this paper, the characterization and capabilities of a patented filter designed to remove radium from drinking water with high efficiency is described. This filter is based on a sandwich structure of silica and green sand, with a natural high content manganese oxide. Both sands are authorized by Spanish authorities to be used in Drinking Water Treatment Plants. The Mn distribution in the green sand was found to be homogenous, thus providing a great number of adsorption sites for radium. Kinetic studies showed that the 226 Ra adsorption on green sand was influenced by the content of major cations solved in the treated water, but the saturation level, about 96-99%, was not affected by it. The physico-chemical parameters of the treated water were unaltered by the filter. The efficiency of the filter for the removal of 226 Ra remained unchanged with large water volumes passed through it, proving its potential use in DWTP. This filter was also able to remove initially the uranium content due to the presence of Fe 2 O 3 particles in it, although it is saturated faster than radium. Copyright © 2016 Elsevier Ltd. All rights reserved.
Energy Technology Data Exchange (ETDEWEB)
NONE
2001-03-01
A new computational dosimetry system for BNCT: JCDS is developed by JAERI in order to carry out BNCT with epithermal neutron beam at present. The development and management situation of computational dosimetry system, which are developed and are used in BNCT facilities in foreign countries, were investigated in order to accurately grasp functions necessary for preparation of the treatment planning and its future subjects. In present state, 'SERA', which are developed by Idaho National Engineering and Environmental Laboratory (INEEL), is used in many BNCT facilities. Followings are necessary for development and management of the treatment planning system. (1) Reliability confirmation of system performance by verification as comparison examination of calculated value with actual experimental measured value. (2) Confirmation systems such as periodic maintenance for retention of the system quality. (3) The improvement system, which always considered relative merits and demerits with other computational dosimetry system. (4) The development of integrated system with patient setting. (author)
Successful BNCT for patients with cutaneous and mucosal melanomas. Report of 4 cases
International Nuclear Information System (INIS)
Morita, Norimasa; Hiratsuka, Junichi; Kuwabara, Chiaki; Aihara, Teruhito; Harada, Tamotsu; Imajo, Yoshinari; Ono, Koji; Fukuda, Hiroshi; Kumada, Hiroaki
2006-01-01
Since 2003 we have conducted BNCT clinical trials on melanomas at the Kyoto University Research Reactor (KUR) and Japan Research Reactor No.4 (JRR-4). We report 4 patients given BNCT for malignant melanomas: 2 with superficial spreading types on the heel, 1 with mucosal melanoma in the nasal cavity, and 1 with a melanoma on the vulva and in the vagina. The two cutaneous melanomas and the nasal cavity mucosal melanoma showed a complete response (CR) by 6 months after BNCT. The residual melanoma showed a partial response (PR) by 3 months after treatment and no regrowth since then. Although two patients experienced normal-tissue damage that exceeded the tolerance level, all the participants were cured within a few months of treatment. BNCT was shown to be a promising treatment for mucosal, as well as for cutaneous, melanomas. (author)
Design of Filter for a Class of Switched Linear Neutral Systems
Directory of Open Access Journals (Sweden)
Caiyun Wu
2013-01-01
Full Text Available This paper is concerned with the filtering problem for a class of switched linear neutral systems with time-varying delays. The time-varying delays appear not only in the state but also in the state derivatives. Based on the average dwell time approach and the piecewise Lyapunov functional technique, sufficient conditions are proposed for the exponential stability of the filtering error dynamic system. Then, the corresponding solvability condition for a desired filter satisfying a weighted performance is established. All the conditions obtained are delay-dependent. Finally, two numerical examples are given to illustrate the effectiveness of the proposed theory.
Energy Technology Data Exchange (ETDEWEB)
Montejo-Garai, Jose R., E-mail: jr@etc.upm.es [Departamento de Electromagnetismo y Teoria de Circuitos, Universidad Politecnica de Madrid, Ciudad Universitaria s/n, Madrid 20840 (Spain); Leal-Sevillano, Carlos A. [Departamento de Electromagnetismo y Teoria de Circuitos, Universidad Politecnica de Madrid, Ciudad Universitaria s/n, Madrid 20840 (Spain); Ruiz-Cruz, Jorge A. [Escuela Politecnica Superior, Universidad Autonoma de Madrid, C/Fco. Tomas y Valiente 11, Madrid 28409 (Spain); Rebollar, Jesus M. [Departamento de Electromagnetismo y Teoria de Circuitos, Universidad Politecnica de Madrid, Ciudad Universitaria s/n, Madrid 20840 (Spain); Estrada, Teresa [T. Laboratorio Nacional de Fusion, Asociacion Euratom-CIEMAT, Madrid 28040 (Spain)
2012-09-15
Highlights: Black-Right-Pointing-Pointer A rigorous systematic design process based on circuit synthesis is proposed for band-stop filters. Black-Right-Pointing-Pointer The new compact E-plane waveguide structure reduces drastically the unwanted resonances in a very large pass band. Black-Right-Pointing-Pointer The manufacturing process together with the computation effort is significantly reduced. Black-Right-Pointing-Pointer Experimental results validate the state-of-art electrical responses. - Abstract: Band-stop or notch filters play a crucial role in plasma diagnosis systems to protect receivers from the stray radiation. In this work, a rigorous design process based on circuit synthesis in addition to an extremely compact E-plane waveguide structure is proposed for this kind of filters. On the one hand, the transfer function verifying the rejection specification is analytically obtained, fixing the minimum number of required cavities. On the other hand, a coupling structure that reduces drastically the unwanted resonances in filters with a very large pass band requirement, is presented. This coupling between the rejection cavities and the main rectangular waveguide has additional advantages; (a) unlike typical inductive irises, large coupling coefficients can be implemented (b) a pure E-plane configuration is achieved, which simplifies the manufacturing and also reduces significantly the computational effort. Experimental validation is demonstrated by two pseudo-elliptic fifth-order band-stop filters fabricated and measured in Ka and V bands. In both cases, the filters are free of spurious resonances in their total operation bands.
Fahrul Hassan, Mohd; Jusoh, Suhada; Zaini Yunos, Muhamad; Arifin, A. M. T.; Ismail, A. E.; Rasidi Ibrahim, M.; Zulafif Rahim, M.
2017-09-01
Portable water filter has grown significantly in recent years. The use of water bottles as a water drink stuff using hand pump water filtration unit has been suggested to replace water bottled during outdoor recreational activities and for emergency supplies. However, quality of water still the issue related to contaminated water due to the residual waste plants, bacteria, and so on. Based on these issues, the study was carried out to design a portable water filter that uses membrane filtration system by applying Design for Six Sigma. Design for Six Sigma methodology consists of five stages which is Define, Measure, Analyze, Design and Verify. There were several tools have been used in each stage in order to come out with a specific objective. In the Define stage, questionnaire approach was used to identify the needs of portable water filter in the future from potential users. Next, Quality Function Deployment (QFD) tool was used in the Measure stage to measure the users’ needs into engineering characteristics. Based on the information in the Measure stage, morphological chart and weighted decision matrix tools were used in the Analyze stage. This stage performed several activities including concept generation and selection. Once the selection of the final concept completed, detail drawing was made in the Design stage. Then, prototype was developed in the Verify stage to conduct proof-of-concept testing. The results that obtained from each stage have been reported in this paper. From this study, it can be concluded that the application of Design for Six Sigma in designing a future portable water filter that uses membrane filtration system is a good start in looking for a new alternative concept with a completed supporting document.
Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT).
Seki, Ryoichi; Wakisaka, Yushi; Morimoto, Nami; Takashina, Masaaki; Koizumi, Masahiko; Toki, Hiroshi; Fukuda, Mitsuhiro
2017-12-01
The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept at an introductory level in the discussion in this tutorial review.
INEEL BNCT research program. Annual report, January 1, 1996--December 31, 1996
International Nuclear Information System (INIS)
Venhuizen, J.R.
1997-04-01
This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of 10 B enriched decaborane
INEEL BNCT research program. Annual report, January 1, 1996--December 31, 1996
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R. [ed.
1997-04-01
This report is a summary of the progress and research produced for the Idaho National Engineering and Environmental Laboratory (INEEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1996. Contributions from the individual investigators about their projects are included, specifically, physics: treatment planning software, real-time neutron beam measurement dosimetry, measurement of the Finnish research reactor epithermal neutron spectrum, BNCT accelerator technology; and chemistry: analysis of biological samples and preparation of {sup 10}B enriched decaborane.
Long-survivors of glioblatoma treated with boron neutron capture therapy (BNCT)
International Nuclear Information System (INIS)
Kageji, T.; Mizobuchi, Y.; Nagahiro, S.; Nakagawa, Y.; Kumada, H.
2011-01-01
The purpose of this study was to compare the radiation dose between long-survivors and non-long-survivors in patients with glioblatoma (GBM) treated with boron neutron capture therapy (BNCT). Among 23 GBM patients treated with BNCT, there were five patients who survived more than three years after diagnosis. The physical and weighted dose of the minimum gross tumor volume (GTV) of long-survivors was much higher than that of non-long survivors with significant statistical differences.
Design of Finite Word Length Linear-Phase FIR Filters in the Logarithmic Number System Domain
Directory of Open Access Journals (Sweden)
Syed Asad Alam
2014-01-01
Full Text Available Logarithmic number system (LNS is an attractive alternative to realize finite-length impulse response filters because of multiplication in the linear domain being only addition in the logarithmic domain. In the literature, linear coefficients are directly replaced by the logarithmic equivalent. In this paper, an approach to directly optimize the finite word length coefficients in the LNS domain is proposed. This branch and bound algorithm is implemented based on LNS integers and several different branching strategies are proposed and evaluated. Optimal coefficients in the minimax sense are obtained and compared with the traditional finite word length representation in the linear domain as well as using rounding. Results show that the proposed method naturally provides smaller approximation error compared to rounding. Furthermore, they provide insights into finite word length properties of FIR filters coefficients in the LNS domain and show that LNS FIR filters typically provide a better approximation error compared to a standard FIR filter.
Spectral design of temperature-invariant narrow bandpass filters for the mid-infrared
DEFF Research Database (Denmark)
Stolberg-Rohr, Thomine Kirstine; Hawkins, Gary J.
2015-01-01
The ability of narrow bandpass filters to discriminatewavelengths between closely-separated gas absorption lines is crucial inmany areas of infrared spectroscopy. As improvements to the sensitivity ofinfrared detectors enables operation in uncontrolled high-temperature environments, this imposes ...
Co-design method for dual-band low-noise amplifier and band-pass filter
Ma, Runbo; Zhang, Wenmei; Han, Guorui; Li, Li; Chen, Xinwei; Han, Liping
2012-04-01
A co-design method for the dual-band low-noise amplifier (LNA) and band-pass filter (BPF) is presented in this study. The dual-band BPF and LNA are designed separately by the traditional method first. In order to reduce the circuit, the dual-band matching networks (MNs) of the LNA and BPF are combined into the dual-band matching-filter. The validity is verified by a sample of 1.57/2.4 GHz LNA-filter after the co-design. The measured S21, NF and BW3 dB are 18.6 dB, 1.98 dB and 0.22 GHz at 1.57 GHz, and 15.2 dB, 1.95 dB and 0.3 GHz at 2.31 GHz, respectively. The results indicate that the co-design and cascade versions have same performance, but the co-design version cuts down the number of the passive components by nearly half.
Directory of Open Access Journals (Sweden)
Amir Reza Dastkhosh
2010-01-01
Full Text Available The effects of adaptive genetic algorithms (AGAs and defected ground structures (DGSs on performance optimization of tapered microstrip filter are investigated. The proposed structure achieves an ultra wide stopband with high attenuation within a small surface area, as well as 45% smaller size, in comparison with conventional filters. The parameters of the filter are optimized using in-home AGA code. In the proposed AGA algorithm, the crossover and mutation probabilities are adaptively changed according to the value of individual fitness. Then by utilizing the proposed DGS, a compact S-band lowpass filter with ultra-wide spurious free window is obtained. The proposed filter achieves an insertion loss of 0.8 dB from DC up to 4 GHz and 21 dB rejection in the stopband from 4.3 up to 60 GHz. The fabricated and measured results exhibit good agreement with the simulated results. They demonstrate that combining AGA and DGS yields best possible response for this group of filters.
A novel deployment design of vena cava filters might be the solution to their blockage problem.
Chen, Zengsheng; Fan, Yubo; Deng, Xiaoyan
2011-12-01
The blockage of a vena cava filter (VCF) by the captured blood clots presents a serious problem to the patients. Commercially available cone-shaped VCFs such as the Gunther Tulip filter has an inherent structural flaw that leads the captured blood clots to be trapped in their front spire areas where the flow-induced shear stress is relatively low so that the clots cannot dissolve fast enough and will accumulate, gradually block the central passages of the filters. It is well known that for a Hagen-Poiseuille flow in a circular tube, the flow-induced shear stress is highest at the wall of the tube and lowest along its axis. Herein, we hypothesize that by reversely deploying a cone-shaped filter in the vena cava, the filter's blockage problem might be prevented. First of all, this kind of deployment scenario can force the captured blood clots to stay in the peripheral areas of the vena cava and keep the central passage of the filter unblocked. Secondly, this scenario can expose the captured blood clots to relatively high shear stress that may dissolve the clots faster. Copyright © 2011 Elsevier Ltd. All rights reserved.
Price, J H; Hunter, E A; Gough, D A
1996-12-01
A method for accurate, real-time image segmentation is needed for the development of a fully automated image cytometer that combines the speed and case-of-use of flow cytometry with the detailed morphometry of imaging. Object intensity variation and inherent optical blur make real-time segmentation challenging. The best spatial finite impulse response (FIR) filter, implemented as a convolution, was tested for sharpening edges and creating the required contrast. The filter and threshold segmentation steps were treated as a two-category linear classifier. Best 3 x 3 through 25 x 25 filters were designed utilizing the perceptron criterion and nonlinear least squares, and tested on ten montage images of a combined 1,070 manually segmented DAPI stained cell nuclei. The resulting image contrast, or class separation, led to simple automatic thresholding via the histogram intermodal minimum. Image segmentation accuracy began to plateau at 7 x 7 filters and did not increase above 15 x 15. Little loss in accuracy occurred with application to the images not used for design. This segmentation method provides a systematic, fast and accurate means of creating binary object maps useful for subsequent measurement, processing and cell classification.
Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT
Akan, Zafer; Demiroglu, Hasan; Avcibasi, Ugur; Oto, Gokhan; Ozdemir, Hulya; Deniz, Sabahattin; Basak, Ali Sadi
2014-01-01
Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching fo...
Improving FoRe: A New Inlet Design for Filtering Samples through Individual Microarray Spots.
de Lange, Victoria; Habegger, Marco; Schmidt, Marco; Vörös, János
2017-03-24
In this publication we present an improvement to our previously introduced vertical flow microarray, the FoRe array, which capitalizes on the fusion of immunofiltration and densely packed micron test sites. Filtering samples through individual microarray spots allows us to rapidly analyze dilute samples with high-throughput and high signal-to-noise. Unlike other flowthrough microarrays, in the FoRe design samples are injected into micron channels and sequentially exposed to different targets. This arrangement makes it possible to increase the sensitivity of the microarray by simply increasing the sample volume or to rapidly reconcentrate samples after preprocessing steps dilute the analyte. Here we present a new inlet system which allows us to increase the analyzed sample volume without compromising the micron spot size and dense layout. We combined this with a model assay to demonstrate that the device is sensitive to the amount of antigen, and as a result, sample volume directly correlates to sensitivity. We introduced a simple technique for analysis of blood, which previously clogged the nanometer-sized pores, requiring only microliter volumes expected from an infant heel prick. A drop of blood is mixed with buffer to separate the plasma before reconcentrating the sample on the microarray spot. We demonstrated the success of this procedure by spiking TNF-α into blood and achieved a limit of detection of 18 pM. Compared to traditional protein microarrays, the FoRe array is still inexpensive, customizable, and simple to use, and thanks to these improvements has a broad range of applications from small animal studies to environmental monitoring.
Complex Membership Grades with an Application to the Design of Adaptive Filters
Directory of Open Access Journals (Sweden)
D. Moses
1999-12-01
Full Text Available In this paper, complex membership grades are introduced for the extension of fuzzy set theory to the complex domain. This model is based on the idea of viewing the complex domain in a linguistic manner, where two linguistic terms are required to define an object. Thus, as opposed to Buckley's model, after fuzzification the two- dimensionality of the universe of discourse is still apparent. One form for representing a complex fuzzy set is using the Cartesian Complex Fuzzy Set representation, which produces complex sets of the form [Z\\tilde]c = [X\\tilde] + j[Y\\tilde]. The motivation for this aberrant representation is oriented from the limitations in using a direct extension to Zadeh, that Buckley introduced. These limitations pose the guidelines for Complex Membership Grades and, therefore, are initially discussed in this paper. Complex Fuzzy Sets are defined and a technique for converting between Complex Fuzzy Sets and Fuzzy Relations is developed based on Cylindrical Extensions and Projections defined by Zadeh. Next, linguistic coordinate transformations are discussed and exemplified by a rule-base coordinate transformation between Polar and Cartesian Complex Fuzzy Sets. Arithmetic operations and defuzzification are demonstrated. The simplicity of these latter operations is crucial when considering implementation prospects. Finally, Complex Membership Grades are applied to the design of adaptive filters. It is shown that a logically derived rule-base can be described, using the linguistic complex domain, for the adaptation process. Emphasis, in this part, is put on the unique characteristics of the complex membership grades model.
Design and Delivery of a Filter for Removal of Siloxanes from the ISS Atmosphere
Carter, Layne; Kayatin, Matthew; Perry, Jay; Agui, Juan; Green, Robert; Gentry, Gregory; Bowman, Elizabeth; Wilson, Mark; Rector, Tony
2016-01-01
Dimethylsilanediol (DMSD) has been identified as a problematic chemical contaminant aboard ISS. This contaminant was initially identified in the ISS condensate and in the Water Processor Assembly (WPA) product water in 2010 when an increasing total organic carbon (TOC) trend was detected in the water produced by the WPA. DMSD is not a crew health hazard at the levels observed in the product water, but it may degrade the performance of the Oxygen Generation System (OGS) which uses product produced by the WPA for electrolysis. In addition, DMSD can prevent the effective operation of the WPA catalytic reactor, and necessitates early replacement of Multifiltration Beds in the WPA. An investigation into the source of DMSD has determined that polydimethylsiloxanes (PDMSs) are hydrolyzing in the Condensing Heat Exchanger (CHX) to form DMSD. PDMSs are prevalent aboard ISS from a variety of sources, including crew hygiene products, adhesives, caulks, lubricants, and various nonmetallics. TPDMSs are also implicated in CHX hydrophilic coating degradation, rendering it hydrophobic and adversely affecting its ability to effectively transmit water to the condensate bus. Eventually this loss in performance results in water droplets in the air flow out of the CHX core, which can lead to microbial growth in the air ducts and can impact the performance of downstream systems. Design concepts have now been developed for removing PDMS in the air stream before it can reach the CHX core, thus preventing degradation of the coating and decomposition of the PDMS to DMSD. This paper summarizes the current status of the effort to deliver filters to ISS for removing PDMSs from the atmosphere before they can adversely impact the performance of the CHX coating and the WPA.
INEL BNCT Research Program, January/February 1993
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R. [ed.
1993-04-01
This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.
TIDBIT - the INEL database of BNCT information and treatment
International Nuclear Information System (INIS)
Mancuso, C.A.
1995-01-01
The INEL Database of BNCT Information and Treatment (TIDBIT) has been under development for several years. Late in 1993, a new software development team took over the project and did and assessment of the current implementation status, and determined that the user interface was unsatisfactory for the expected users and that the data structures were out of step with the current state of reality. The team evaluated several tools that would improve the user interface to make the system easier to use. Uniface turned out to be the product of choice. During 1994, TIDBIT got its name, underwent a complete change of appearance, had a major overhaul to the data structures that support the application, and system documentation was begun. A prototype of the system was demonstrated in September 1994
INEL BNCT Research Program, May/June 1992
International Nuclear Information System (INIS)
Venhuizen, J.R.
1992-09-01
This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (IBPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed
INEL BNCT Research Program, September--October 1992
International Nuclear Information System (INIS)
Venhuizen, J.R.
1992-12-01
This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotain. carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophonylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed
INEL BNCT Research Program, September--October 1992
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R.
1992-12-01
This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotain. carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophonylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.
INEL BNCT Research Program, January/February 1993
International Nuclear Information System (INIS)
Venhuizen, J.R.
1993-04-01
This report presents summaries for two months of current research of the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murine screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor cell culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronophenylaianine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed
INEL BNCT Research Program, March/April 1992
Energy Technology Data Exchange (ETDEWEB)
Venhuizen, J.R.
1992-09-01
This report presents summaries for two months of current research for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and murino screening experiments of low-density lipoprotein, carboranyl alanine, and liposome boron containing compounds. Pituitary tumor call culture studies are described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and boronopheoylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.
International Nuclear Information System (INIS)
Capala, J.; Diaz, A.Z.; Chadha, M.
1997-01-01
The abstract describes evaluation of boron neutron capture therapy (BNCT) for two groups of glioblastoma multiforme patients. From September 1994 to February 1996 15 patients have been treated. In September 1997 another 34 patients were examined. Authors determined a safe starting dose for BNCT using epithermal neutrons and BPA-F. They have also evaluated adverse effects of BNCT at this starting dose. Therapeutic effectiveness of this starting dose has been evaluated. No significant side effects from BPA-F infusion or BNCT treatment were observed in normal brains
Energy Technology Data Exchange (ETDEWEB)
Capala, J. [Brookhaven National Lab., Upton, NY (United States); Diaz, A.Z.; Chadha, M. [Univ. Hospital, State Univ. of New York, NY (United States)] [and others
1997-12-31
The abstract describes evaluation of boron neutron capture therapy (BNCT) for two groups of glioblastoma multiforme patients. From September 1994 to February 1996 15 patients have been treated. In September 1997 another 34 patients were examined. Authors determined a safe starting dose for BNCT using epithermal neutrons and BPA-F. They have also evaluated adverse effects of BNCT at this starting dose. Therapeutic effectiveness of this starting dose has been evaluated. No significant side effects from BPA-F infusion or BNCT treatment were observed in normal brains.
International Nuclear Information System (INIS)
Miller, Marcelo E.; Sztejnberg, Manuel L.; Gonzalez, Sara J.; Thorp, Silvia I.; Longhino, Juan M.; Estryk, Guillermo
2011-01-01
Purpose: A rhodium self-powered neutron detector (Rh SPND) has been specifically developed by the Comision Nacional de Energia Atomica (CNEA) of Argentina to measure locally and in real time thermal neutron fluxes in patients treated with boron neutron capture therapy (BNCT). In this work, the thermal and epithermal neutron response of the Rh SPND was evaluated by studying the detector response to two different reactor spectra. In addition, during clinical trials of the BNCT Project of the CNEA, on-line neutron flux measurements using the specially designed detector were assessed. Methods: The first calibration of the detector was done with the well-thermalized neutron spectrum of the CNEA RA-3 reactor thermal column. For this purpose, the reactor spectrum was approximated by a Maxwell-Boltzmann distribution in the thermal energy range. The second calibration was done at different positions along the central axis of a water-filled cylindrical phantom, placed in the mixed thermal-epithermal neutron beam of CNEA RA-6 reactor. In this latter case, the RA-6 neutron spectrum had been well characterized by both calculation and measurement, and it presented some marked differences with the ideal spectrum considered for SPND calibrations at RA-3. In addition, the RA-6 neutron spectrum varied with depth in the water phantom and thus the percentage of the epithermal contribution to the total neutron flux changed at each measurement location. Local (one point-position) and global (several points-positions) and thermal and mixed-field thermal neutron sensitivities were determined from these measurements. Thermal neutron flux was also measured during BNCT clinical trials within the irradiation fields incident on the patients. In order to achieve this, the detector was placed on patient's skin at dosimetric reference points for each one of the fields. System stability was adequate for this kind of measurement. Results: Local mixed-field thermal neutron sensitivities and global
Miller, Marcelo E; Sztejnberg, Manuel L; González, Sara J; Thorp, Silvia I; Longhino, Juan M; Estryk, Guillermo
2011-12-01
A rhodium self-powered neutron detector (Rh SPND) has been specifically developed by the Comisión Nacional de Energía Atómica (CNEA) of Argentina to measure locally and in real time thermal neutron fluxes in patients treated with boron neutron capture therapy (BNCT). In this work, the thermal and epithermal neutron response of the Rh SPND was evaluated by studying the detector response to two different reactor spectra. In addition, during clinical trials of the BNCT Project of the CNEA, on-line neutron flux measurements using the specially designed detector were assessed. The first calibration of the detector was done with the well-thermalized neutron spectrum of the CNEA RA-3 reactor thermal column. For this purpose, the reactor spectrum was approximated by a Maxwell-Boltzmann distribution in the thermal energy range. The second calibration was done at different positions along the central axis of a water-filled cylindrical phantom, placed in the mixed thermal-epithermal neutron beam of CNEA RA-6 reactor. In this latter case, the RA-6 neutron spectrum had been well characterized by both calculation and measurement, and it presented some marked differences with the ideal spectrum considered for SPND calibrations at RA-3. In addition, the RA-6 neutron spectrum varied with depth in the water phantom and thus the percentage of the epithermal contribution to the total neutron flux changed at each measurement location. Local (one point-position) and global (several points-positions) and thermal and mixed-field thermal neutron sensitivities were determined from these measurements. Thermal neutron flux was also measured during BNCT clinical trials within the irradiation fields incident on the patients. In order to achieve this, the detector was placed on patient's skin at dosimetric reference points for each one of the fields. System stability was adequate for this kind of measurement. Local mixed-field thermal neutron sensitivities and global thermal and mixed
Jamora, Dennis A.
1993-01-01
Ground clutter interference is a major problem for airborne pulse Doppler radar operating at low altitudes in a look-down mode. With Doppler zero set at the aircraft ground speed, ground clutter rejection filtering is typically accomplished using a high-pass filter with real valued coefficients and a stopband notch centered at zero Doppler. Clutter spectra from the NASA Wind Shear Flight Experiments of l991-1992 show that the dominant clutter mode can be located away from zero Doppler, particularly at short ranges dominated by sidelobe returns. Use of digital notch filters with complex valued coefficients so that the stopband notch can be located at any Doppler frequency is investigated. Several clutter mode tracking algorithms are considered to estimate the Doppler frequency location of the dominant clutter mode. From the examination of night data, when a dominant clutter mode away from zero Doppler is present, complex filtering is able to significantly increase clutter rejection over use of a notch filter centered at zero Doppler.
Design of 50 G nonpolarizing dense wavelength division multiplexer angle-tuning bandpass filter.
Chen, Xianming; Ma, Junxian; Yang, Yatao
2010-10-01
Transmission characteristic differences of a narrow bandpass filter between p- and s-polarized light, especially the central wavelength separation, will corrupt the performance of the filter when the incidence is oblique. In this paper, by adding high-index materials asymmetrically to both sides of a low-index spacer, which tunes the equivalent index of the spacer, the central wavelengths of the two polarizations coincide perfectly when in 20° incidence; with different reflected layers on the two sides of the spacers and replacing some reflected layers with equivalent layers, the 0.5 dB normalized passband width is kept at 0.2 nm, which meets the requirement of the 50 G dense wavelength division multiplexer filter.
Design of low noise class D amplifiers using an integrated filter
Haishi, Wang; Bo, Zhang
2012-11-01
This paper investigates the noise sources in a single-ended class D amplifier (SECDA) and suggests corresponding ways to lower the noise. The total output noise could be expressed as a function of the gain and noises from different sources. According to the function, the bias voltage (VB) is a primary noise source, especially for a SECDA with a large gain. A low noise SECDA is obtained by integrating a filter into the SECDA to lower the noise of the VB. The filter utilizes an active resister and an 80 pF capacitance to get a 3 Hz pole. A noise test and fast Fourier transform analysis show that the noise performance of this SECDA is the same as that of a SECDA with an external filter.
Directory of Open Access Journals (Sweden)
Duc Toan Nguyen
2016-02-01
Full Text Available Abstract We report on the fabrication of miniaturized NIR spectrometers based on arrays of multiple Fabry-Pérot (FP filters. The various cavities of different height are fabricated via a single patterning step using high resolution 3D nanoimprint technology. Today, low-cost patterning of extended cavity heights for NIR filters using the conventional spin-coated nanoimprint methodology is not available because of insufficient coating layers and low mobility of the resist materials to fill extended cavity structures. Our investigation focuses on reducing the technological effort for fabrication of homogeneous extended cavities. We study alternative cavity designs, including a new resist and apply large-area 3D nanoimprint based on hybrid mold and UV Substrate Conformal Imprint Lithography (UV-SCIL to overcome these limitations. We compare three different solutions, i.e. (1 applying multiple spin coating of the resist to obtain thicker initial resist layers, (2 introducing a hybrid cavity (combination of a thin oxide layer and the organic cavity to compensate the height differences, and (3 optimizing the imprint process with a novel resist material. The imprint results based on these methods demonstrate the implementation of NIR FP filters with high transmission intensity (best single filter transmission >90 % and small line widths (<5 nm in full width at half maximum.
Autocorrelation noise removal for optical coherence tomography by sparse filter design
Seck, Hon Luen; Zhang, Ying; Soh, Yeng Chai
2012-07-01
We present a reconstruction method to eliminate the autocorrelation noise (ACN) in optical coherence tomography (OCT). In this method, the optical fields scattered from the sample features are regarded as the response of a sparse finite impulse response (FIR) filter. Then the OCT reconstruction is formulated as one of identifying the parameters of a sparse FIR filter, which are obtained via an ℓ1 optimization with soft thresholding. The experimental results show that the proposed method can obtain OCT reconstruction results with effective attenuation of ACN.
Design of Multiplier-less FIR filters with Simultaneously Variable Bandwidth and Fractional Delay
Directory of Open Access Journals (Sweden)
Aravind Illa
2016-09-01
Full Text Available Low complexity and reconfigurability are the key features in emerging communication applications in order to support multi-standards and operation modes. To obtain these features, an efficient implementation of finite impulse response (FIR filter, with Variable Bandwidth and Fractional Delay, is proposed in this paper. The reduction in the implementation complexity is achieved by converting the continuous filter coefficients to signed power of two (SPT space. This may lead to performance degradation. Hence, in this paper, Artificial Bee Colony (ABC optimization is deployed for finding the near optimal solution in the discrete space.
Filtered Mass Density Function for Design Simulation of High Speed Airbreathing Propulsion Systems
Drozda, T. G.; Sheikhi, R. M. H.; Givi, P.; Drummond, J. Philip (Technical Monitor)
2002-01-01
The objective of this research is to develop and implement a new methodology for large eddy simulation of (LES) of high-speed reacting turbulent flows. We have just completed 2 1/2 years of Phase I of this research. The work within the past six months was concentrated on the following two subjects: (1) Development of the joint velocity-scalar filtered density function (VSFDF) scheme for LES. (2) Implementation of our previously developed scalar filtered density function (SFDF) for flame simulations.
Design of the Trap Filter for the High Power Converters with Parallel Interleaved VSCs
DEFF Research Database (Denmark)
Gohil, Ghanshyamsinh Vijaysinh; Bede, Lorand; Teodorescu, Remus
2014-01-01
The power handling capability of the state-of-the-art semiconductor devices is limited. Therefore, the Voltage Source Converters (VSCs) are often connected in parallel to realize high power converter. The switching frequency semiconductor devices, used in the high power VSCs, is also limited....... Therefore, large filter components are often required in order to meet the stringent grid code requirements imposed by the utility. As a result, the size, weight and cost of the overall system increase. The use of interleaved carriers of the parallel connected VSCs, along with the high order line filter...
Directory of Open Access Journals (Sweden)
Kenshi Saho
2017-07-01
Full Text Available We present a strategy for designing an α - β - η - θ filter, a fixed-gain moving-object tracking filter using position and velocity measurements. First, performance indices and stability conditions for the filter are analytically derived. Then, an optimal gain design strategy using these results is proposed and its relationship to the position-velocity-measured (PVM Kalman filter is shown. Numerical analyses demonstrate the effectiveness of the proposed strategy, as well as a performance improvement over the traditional position-only-measured α - β filter. Moreover, we apply an α - β - η - θ filter designed using this strategy to ultra-wideband Doppler radar tracking in numerical simulations. We verify that the proposed strategy can easily design the gains for an α - β - η - θ filter based on the performance of the ultra-wideband Doppler radar and a rough approximation of the target’s acceleration. Moreover, its effectiveness in predicting the steady state performance in designing the position-velocity-measured Kalman filter is also demonstrated.
Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases in BDIX rats
International Nuclear Information System (INIS)
Trivillin, V.A.; Garabalino, M.A.; Colombo, L.L.
2013-01-01
Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases in BDIX rats Introduction: Boron Neutron Capture Therapy (BNCT) is based on selective tumor uptake of boron compounds, followed by neutron irradiation. BNCT was proposed for the treatment of unresectable, diffuse lung metastases. The aim of the present study was to perform BNCT studies in an experimental model of lung metastases. Materials and Methods: 3 x 106/0.5 ml colon carcinoma cells (DHD/K12/TRb) were injected iv in syngeneic BDIX rats. Three weeks post-inoculation, rats with diffuse lung metastases were used for in vivo BNCT studies in the RA-3 Nuclear Reactor. Based on previous biodistribution studies and computational dosimetry with Monte Carlo simulation, 2 doses were prescribed, i.e. 4 Gy and 8 Gy minimum absorbed dose to tumor. The animals were assigned to 5 experimental groups (n= 4 to 8) at each dose level: T0 (euthanized pre-treatment), BPA-BNCT, Comb-BNCT (BPA+GB-10), Beam only (background dose) and Sham (same manipulation, no treatment). Boron concentration was measured in a blood sample taken pre-irradiation to verify that the value was in the range established in previous biodistribution studies. The animals were followed clinically for 2 weeks after neutron irradiation and then euthanized to assess the response of tumor and normal lung, macroscopically and histologically. To date we have evaluated the end-point weight of lung (normal lung + metastases) and % lung weight/body weight as an indicator of tumor growth. Results: The statistical analysis (ANOVA) of % lung weight/body weight showed statistically significant differences (p<0.05) between groups T0 (0.79 ± 0.38) and Sham (1.87 ± 0.91). No statistically significant differences were observed between the Beam only groups (at both dose levels) and Sham. Similar and statistically significant tumor control was induced in the groups BPA-BNCT Low dose (LD) (0.56 ± 0.11), BPA-BNCT High dose (HD) (0.80 ± 0.16), Comb-BNCT
Shanechi, Maryam M; Orsborn, Amy L; Carmena, Jose M
2016-04-01
Much progress has been made in brain-machine interfaces (BMI) using decoders such as Kalman filters and finding their parameters with closed-loop decoder adaptation (CLDA). However, current decoders do not model the spikes directly, and hence may limit the processing time-scale of BMI control and adaptation. Moreover, while specialized CLDA techniques for intention estimation and assisted training exist, a unified and systematic CLDA framework that generalizes across different setups is lacking. Here we develop a novel closed-loop BMI training architecture that allows for processing, control, and adaptation using spike events, enables robust control and extends to various tasks. Moreover, we develop a unified control-theoretic CLDA framework within which intention estimation, assisted training, and adaptation are performed. The architecture incorporates an infinite-horizon optimal feedback-control (OFC) model of the brain's behavior in closed-loop BMI control, and a point process model of spikes. The OFC model infers the user's motor intention during CLDA-a process termed intention estimation. OFC is also used to design an autonomous and dynamic assisted training technique. The point process model allows for neural processing, control and decoder adaptation with every spike event and at a faster time-scale than current decoders; it also enables dynamic spike-event-based parameter adaptation unlike current CLDA methods that use batch-based adaptation on much slower adaptation time-scales. We conducted closed-loop experiments in a non-human primate over tens of days to dissociate the effects of these novel CLDA components. The OFC intention estimation improved BMI performance compared with current intention estimation techniques. OFC assisted training allowed the subject to consistently achieve proficient control. Spike-event-based adaptation resulted in faster and more consistent performance convergence compared with batch-based methods, and was robust to parameter
First clinical results on the finnish study on BPA-mediated BNCT in glioblastoma
International Nuclear Information System (INIS)
Kankaanranta, L.; Seppaelae, T.; Kallio, M.
2000-01-01
An open phase I dose-escalation boron neutron capture therapy (BNCT) study on glioblastoma multiforme (GBM) was initiated at the BNCT facility FiR 1, Espoo, Finland, in May 1999. The aim of the study is to investigate the safety of boronophenylalanine (BPA)-mediated BNCT. Ten GBM patients were treated with a 2-field treatment plan using one fraction. BPA-F was used as the 10 B carrier infused as a fructose solution 290 mg BPA/kg over 2-hours prior to irradiation with epithermal neutrons. Average doses to the normal brain, contrast enhancing tumour, and the target ranged from 3.0 to 5.6 Gy (W), from 35.1 to 66.7 Gy (W), and from 29.6 to 53.6 Gy (W), respectively. BNCT was associated with acceptable toxicity. The median follow-up is 9 months (range, 3 to 16 months) post diagnosis in July 2000. Seven of the 10 patients have recurrent or persistent GBM, and the median time to progression is 8 months. Only one patient has died, and the estimated 1-year overall survival is 86%. Five of the recurrent tumours were treated with external beam photon radiation therapy to the total dose of 30-40 Gy with few acute side-effects. These preliminary findings suggest that acute toxicity of BPA-mediated BNCT is acceptable when average brain doses of 5.6 Gy (W) or less are used. The followup time is too short to evaluate survival, but the estimated 1-year survival of 86% achieved with BNCT followed by conventional photon irradiation at the time of tumour progression is encouraging and emphasises the need of further investigation of BPA-mediated BNCT. (author)
A numerical design approach for single amplifier, Active-RC Butterworth filter of order 5
DEFF Research Database (Denmark)
Gaunholt, Hans
2007-01-01
filter applying just one operational amplifier coupled as a unity gain amplifier. It is shown that the influence from the real operational amplifier may be reduced by trimming just one resistor in the circuit. The unity gain amplifiers have the advantage of providing low power consumption, yielding...
Sufficient Condition for Estimation in Designing H∞ Filter-Based SLAM
Directory of Open Access Journals (Sweden)
Nur Aqilah Othman
2015-01-01
Full Text Available Extended Kalman filter (EKF is often employed in determining the position of mobile robot and landmarks in simultaneous localization and mapping (SLAM. Nonetheless, there are some disadvantages of using EKF, namely, the requirement of Gaussian distribution for the state and noises, as well as the fact that it requires the smallest possible initial state covariance. This has led researchers to find alternative ways to mitigate the aforementioned shortcomings. Therefore, this study is conducted to propose an alternative technique by implementing H∞ filter in SLAM instead of EKF. In implementing H∞ filter in SLAM, the parameters of the filter especially γ need to be properly defined to prevent finite escape time problem. Hence, this study proposes a sufficient condition for the estimation purposes. Two distinct cases of initial state covariance are analysed considering an indoor environment to ensure the best solution for SLAM problem exists along with considerations of process and measurement noises statistical behaviour. If the prescribed conditions are not satisfied, then the estimation would exhibit unbounded uncertainties and consequently results in erroneous inference about the robot and landmarks estimation. The simulation results have shown the reliability and consistency as suggested by the theoretical analysis and our previous findings.
Research and Design on Trigger System Based on Acoustic Delay Correlation Filtering
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Zhiyong Lei
2014-01-01
Full Text Available In the exterior trajectory test, there usually needs a muzzle or a gun muzzle trigger system to be used as start signal for other measuring device, the customary trigger systems include off- target, infrared and acoustic detection system. But inherent echo reflection of the acoustic detection system makes the original signal of sound trigger submerged in various echo interference for bursts and shooting in a closed room, so that it can’t produce accurate trigger. In order to solve this defect, this paper analyzed the mathematical model based on acoustic delay correlation filtering in detail, then put forward the constraint condition with minimum path for delay correlation filtering. In this constraint condition, delay correlation filtering can do de-noising operation accurately. In order to verify accuracy and actual performance of the model, a MEMS sound sensor was used to implement mathematical model onto project, experimental results show that this system can filter out the every path sound bounce echoes of muzzle shock wave signal and produce the desired trigger signal accurately.
Design of Two-channel Half-band Bank of Digital Filters using Optimization Methods
Czech Academy of Sciences Publication Activity Database
Gescheidtová, E.; Kubásek, J.; Smékal, Z.; Bartušek, Karel
2007-01-01
Roč. 40, č. 1 (2007), s. 71-79 ISSN 1738-6438 R&D Projects: GA ČR(CZ) GA102/07/0389; GA ČR(CZ) GA102/07/1086 Institutional research plan: CEZ:AV0Z20650511 Keywords : criterial function * transfer function * bank of digital filters Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering
DEFF Research Database (Denmark)
Lacouture Parodi, Yesenia; Rubak, Per
2011-01-01
simulated for each case. In order to obtain optimum parameters the bandwidths, filter lengths and regularization constants were varied for each loudspeaker configuration and each method and a description is given of the simulations performed and the results obtained. The simulation results are documented...
Barca, Cristian; Roche, Nicolas; Troesch, Stéphane; Andrès, Yves; Chazarenc, Florent
2018-01-15
Steel slag filters, if well designed and operated, may upgrade phosphorus removal in small wastewater treatment plants such as stabilization ponds and constructed wetlands. The main objective of this study was to develop a systemic modelling approach to describe changes in the hydraulic performances and internal hydrodynamics of steel slag filters under real dynamic operating conditions. The experimental retention time distribution curves (RTD curves) determined from tracer experiments performed at different times during the first year of operation of two field-scale steel slag filters were analyzed through a three stage process. First, a statistical analysis of the RTD curves was performed to determine statistical parameters of the retention time distribution. Second, classical tanks in series (TIS) and plug flow with dispersion (PFD) models were used to obtain a first evaluation of the dispersion and mixing regime. Finally, a multi-flow path TIS model, based on the assumption of several flow paths with different hydraulic properties, is proposed to accurately describe the internal hydrodynamics. Overall, the results of this study indicate that higher CaO content, round shape, and larger grain size distribution of steel slag may promote plug-like flow rather than dispersion. The results of the multi-flow path TIS model suggest that the internal hydrodynamics of steel slag filters can be primarily described by two main flow paths: (i) a faster main flow path showing higher plug flow, followed by (ii) a slower secondary flow path showing higher dispersion. The results also showed that internal hydrodynamics may change over time as a consequence of physical-chemical phenomena occurring in the filter, including accumulation of precipitates, slag hydration and carbonation, and particle segregation. Copyright © 2017 Elsevier Ltd. All rights reserved.
Aboutabikh, Kamal; Aboukerdah, Nader
2015-07-01
In this paper, we propose a practical way to synthesize and filter an ECG signal in the presence of four types of interference signals: (1) those arising from power networks with a fundamental frequency of 50Hz, (2) those arising from respiration, having a frequency range from 0.05 to 0.5Hz, (3) muscle signals with a frequency of 25Hz, and (4) white noise present within the ECG signal band. This was done by implementing a multiband digital filter (seven bands) of type FIR Multiband Least Squares using a digital programmable device (Cyclone II EP2C70F896C6 FPGA, Altera), which was placed on an education and development board (DE2-70, Terasic). This filter was designed using the VHDL language in the Quartus II 9.1 design environment. The proposed method depends on Direct Digital Frequency Synthesizers (DDFS) designed to synthesize the ECG signal and various interference signals. So that the synthetic ECG specifications would be closer to actual ECG signals after filtering, we designed in a single multiband digital filter instead of using three separate digital filters LPF, HPF, BSF. Thus all interference signals were removed with a single digital filter. The multiband digital filter results were studied using a digital oscilloscope to characterize input and output signals in the presence of differing sinusoidal interference signals and white noise. Copyright © 2015 Elsevier Ltd. All rights reserved.
Evaluation of neutron irradiation fields for BNCT by using absorbed dose in a phantom
International Nuclear Information System (INIS)
Aizawa, O.
1993-01-01
In a previous paper, the author defined the open-quotes irradiation timeclose quotes as the time of irradiation in which the maximum open-quotes total background doseclose quotes becomes 2,500 RBE-cGy. In this paper, he has modified the definition a little as the time of irradiation in which the maximum open-quotes lμg/g B-10 doseclose quotes becomes 3,000 RBE-cGy, because he assumed that normal tissue contained 1μg/g B-10. Moreover, he has modified the dose criteria for BNCT as follows: The open-quotes eye doseclose quotes, open-quotes total body doseclose quotes and open-quotes except-head doseclose quotes should be less that 200, 100 and 50 RBE-cGy, respectively. He has added one more criterion for BNCT that the thermal neutron fluence at the tumor position should be over 2.5x10 12 n/cm 2 at the open-quotes irradiation timeclose quotes. The distance from the core side to the irradiation port in the open-quotes old configurationclose quotes of the Musashi reactor (TRIGA-II, 100kW) was 160 cm. He is now planning to design an eccentric core and to move the reactor core nearer to the irradiation port, distance between the core side and the irradiation port to be 140, 130 and 120cm. The other assumptions used in this paper are as follows: (1) The B-10 concentrations in tumor are 30 and/or 10μg/g. (2) The depth of the tumor is 5.0 cm to 5.5 cm from the surface. (3) The RBE values used are 1.0 for all gamma rays and 2.3 for B 10 (n,α) reaction products. (4) The RBE values for neutrons are the following three cases: the first case is using 1.6 for all neutrons; the second one is using 3.2 for non-thermal neutrons and 1.6 for thermal neutrons; the third case is using 4.8 for fast neutrons, 3.2 for faster epithermal and epithermal neutrons, and 1.6 for thermal neutrons
Directory of Open Access Journals (Sweden)
Tommy K.K. Ngai
2014-06-01
Full Text Available Low-cost household water treatment systems are innovations designed to improve the quality of drinking water at the point of use. This study investigates how an NGO can design appropriate programme strategies in order to increase the adoption and sustained use of household sand filters in rural India. A system dynamics computer model was developed and used to assess 18 potential programme strategies for their effectiveness in increasing filter use at two and ten years into the future, under seven scenarios of how the external context may plausibly evolve. The results showed that the optimal choice of strategy is influenced by the macroeconomic situation, donor funding, presence of alternative options, and the evaluation time frame. The analysis also revealed some key programme management challenges, including the trade-off between optimising short- or long-term gains, and counter-intuitive results, such as higher subsidy fund allocation leading to fewer filter distribution, and technology advances leading to fewer sales. This study outlines how an NGO can choose effective strategies in consideration of complex system interactions. This study demonstrated that small NGOs can dramatically increase their programme outcomes without necessarily increasing operational budget.
Accelerator based-boron neutron capture therapy (BNCT)-clinical QA and QC
International Nuclear Information System (INIS)
Suzuki, Minoru; Tanaka, Hiroki; Sakurai, Yoshinori; Yong, Liu; Kashino, Genro; Kinashi, Yuko; Masunaga, Shinichiro; Ono, Koji; Maruhashi, Akira
2009-01-01
Alpha-particle and recoil Li atom yielded by the reaction ( 10 B, n), due to their high LET properties, efficiently and specifically kill the cancer cell that has incorporated the boron. Efficacy of this boron neutron capture therapy (BNCT) has been demonstrated mainly in the treatment of recurrent head/neck and malignant brain cancers in Kyoto University Research Reactor Institute (KUR). As the clinical trial of BNCT is to start from 2009 based on an accelerator (not on the Reactor), this paper describes the tentative outline of the standard operation procedure of BNCT for its quality assurance (QA) and quality control (QC) along the flow of its clinical practice. Personnel concerned in the practice involve the attending physician, multiple physicians in charge of BNCT, medical physicists, nurses and reactor stuff. The flow order of the actual BNCT is as follows: Pre-therapeutic evaluation mainly including informed consent and confirmation of the prescription; Therapeutic planning including setting of therapy volume, and of irradiation axes followed by meeting for stuffs' agreement, decision of irradiating field in the irradiation room leading to final decision of the axis, CT for the planning, decision of the final therapeutic plan according to Japan Atomic Energy Agency-Computational Dosimetry System (JCDS) and meeting of all related personnel for the final confirmation of therapeutic plan; and BNCT including the transport of patient to KUR, dripping of boronophenylalanine, setting up of the patient on the machine, blood sampling for pharmacokinetics, boron level measurement for decision of irradiating time, switch on/off of the accelerator, confirmation of patient's movement in the irradiated field after the neutron irradiation, blood sampling for confirmation of the boron level, and patient's leave from the room. The QA/QC check is principally to be conducted with the two-person rule. The purpose of the clinical trial is to establish the usefulness of BNCT
Scaling function based on Chinese remainder theorem applied to a recursive filter design
Directory of Open Access Journals (Sweden)
Stamenković Negovan
2014-01-01
Full Text Available Implementation of IIR filters in residue number system (RNS architecture is more complex in comparison to FIR filters, due to introduction of the scaling function. This function performs operation of division by a constant factor, which is usually the power of two, and after that the operation of rounding. In that way dynamic range reduction in digital systems is achieved. There are different methods for scaling operation implementation, already presented in references. In this paper, some RNS dynamic reduction techniques have been analyzed and then application of one selected technique has been presented on example. In all RNS calculations the power of two moduli set {2n-1, 2n, 2n+1} has been applied. [Projekat Ministarstva nauke Republike Srbije, br. 32009TR
Large-angle scattered light measurements for quantum-noise filter cavity design studies.
Magaña-Sandoval, Fabian; Adhikari, Rana X; Frolov, Valera; Harms, Jan; Lee, Jacqueline; Sankar, Shannon; Saulson, Peter R; Smith, Joshua R
2012-08-01
Optical loss from scattered light could limit the performance of quantum-noise filter cavities being considered for an upgrade to the Advanced Laser Interferometer Gravitational Wave Observatory (LIGO) gravitational-wave detectors. This paper describes imaging scatterometer measurements of the large-angle scattered light from two high-quality sample optics, a high reflector and a beamsplitter. These optics are each superpolished fused silica substrates with silica:tantala dielectric coatings. They represent the current state-of-the art optical technology for use in filter cavities. We present angle-resolved scatter values and integrate these to estimate the total scatter over the measured angles. We find that the total integrated light scattered into larger angles can be as small as 4 ppm.
Design of a SIW Bandpass Filter Using Defected Ground Structure with CSRRs
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Weiping Li
2017-01-01
Full Text Available In this paper, a substrate integrated waveguide (SIW bandpass filter using defected ground structure (DGS with complementary split ring resonators (CSRRs is proposed. By using the unique resonant properties of CSRRs and DGSs, two passbands with a transmission zero in the middle have been achieved. The resonant modes of the two passbands are different and the bandwidth of the second passband is much wider than that of the first one. In order to increase out-of-band rejection, a pair of dumbbell DGSs has been added on each side of the CSRRs. The structure is analyzed using equivalent circuit models and simulated based on EM simulation software. For validation, the proposed filter is fabricated and measured. The measurement results are in good agreement with the simulated ones.
Joint Filter and Waveform Design for Radar STAP in Signal Dependent Interference (Preprint)
2015-10-01
discussions and are expressed below Definition 3. ( Lipschitz continuous gradient) A function f(x̄) : RN → R has a Lipschitz constant (and trivially... function of the waveform causing the joint reliever filter and waveform optimization to be non-convex with no closed form solution. However, it is...of the STAP objective via strongly convex functions resulting in the constrained proximal alternating minimization [18]. Proximal algorithms
Achilli, Cesare; Grandi, Stefania; Ciana, Annarita; Guidetti, Gianni F; Malara, Alessandro; Abbonante, Vittorio; Cansolino, Laura; Tomasi, Corrado; Balduini, Alessandra; Fagnoni, Maurizio; Merli, Daniele; Mustarelli, Piercarlo; Canobbio, Ilaria; Balduini, Cesare; Minetti, Giampaolo
2014-04-01
Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a (10)B-containing drug and subsequent irradiation with low energy neutrons, which bring about the decay of (10)B to (7)Li and an α particle, causing the death of the neoplastic cell. The effectiveness of BNCT is limited by the low delivery and accumulation of the used boron-containing compounds. Here we report the development and the characterization of BPO4 nanoparticles (NPs) as a novel possible alternative drug for BNCT. An extensive analysis of BPO4 NP biocompatibility was performed using both mature blood cells (erythrocytes, neutrophils and platelets) and a model of hematopoietic progenitor cells. A time- and concentration-dependent cytotoxicity study was performed on neoplastic coloncarcinoma and osteosarcoma cell lines. BPO4 functionalization with folic acid, introduced to improve the uptake by tumor cells, appeared to effectively limit the unwanted effects of NPs on the analyzed blood components. Boron neutron capture therapy (BNCT) is a radiotherapy treatment modality based on the accumulation of a (10)B-containing drug and subsequent irradiation with low energy neutrons, inducing the decay of (10)B to (7)Li and an α particle, causing neoplastic cell death. This team of authors reports on a folic acid functionalized BPO4 nanoparticle with improved characteristics compared with conventional BNCT approaches, as demonstrated in tumor cell lines, and hopefully to be followed by translational human studies. © 2014.
Monte Carlo simulation to study the doses in an accelerator BNCT treatment
International Nuclear Information System (INIS)
Burlon, Alejandro A.; Valda, Alejandro A.; Somacal, Hector R.; Kreiner, Andres J.; Minsky, Daniel M.
2003-01-01
In this work the 7 Li(p, n) 7 Be reaction has been studied as a neutron source for accelerator-based BNCT (Boron Neutron Capture Therapy). In order to optimize the design of the neutron production target and the beam shaping assembly, extensive MCNP simulations have been performed. These simulations include a thick Li metal target, a whole-body phantom, a moderator-reflector assembly (Al/AlF 3 as moderator and graphite as reflector) and the treatment room. The doses were evaluated for two proton bombarding energies of 1.92 MeV (near to the threshold of the reaction) and 2.3 MeV (near to the resonance of the reaction) and for three Al/ALF 3 moderator thicknesses (18, 26 and 34 cm). To assess the doses, a comparison using a Tumor Control Probability (TCP) model was done. In a second instance, the effect of the specific skin radiosensitivity (an RBE of 2.5 for the 10 B(n,α) 7 Li reaction) and a 10 B uptake of 17 ppm was considered for the scalp. Finally, the simulations show the advantage of irradiating with near-resonance-energy protons (2.3 MeV) because of the high neutron yield at this energy, leading to the lowest treatment times. Moreover, the 26 cm Al/AlF 3 moderator has shown the best performance among the studied cases. (author)
BDTPS The BNCT Treatment Planning System jointly developed at DIMNP and JRC/IE
Daquino, G G; Mazzini, M; Moss, R; Muzi, L; International Workshop on "Neutron Capture Therapy: State of the art"
2003-01-01
The idea to couple the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the new methodology set-up at DIMNP of University of Pisa, in collaboration with the JRC of Petten (NL). The methodology has been implemented in the new TPS, called BDTPS (Boron Distribution Treatment Planning System), which takes into account the actual boron distribution in the patient brain, while the standard TPS assumes a uniform boron distribution, absolutely far from the reality. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The new TPS, based on the Monte Carlo technique, has been validated comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designed, as calculated by the BDTPS and by the standard TPS SERA. An evident SERA overestimation of the thermal neutron flux, as well as the boron dose, has been detect...
Synthesis and in-vivo detection of boronated compounds for use in BNCT
Energy Technology Data Exchange (ETDEWEB)
Kabalka, G.W.
1991-02-01
The primary objectives of the DOE Program at the University of Tennessee Biomedical Imaging Center are the development of new boron-neutron-capture agents as well as the technology to detect boron compounds in-vivo. The detection technology focuses on the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring BNCT agents in-vivo. A significant portion of the effort is directed toward the design of boron-containing neutron-capture-therapy agents. The UT -- DOE program is unique in that it has access to two state-of-the-art multinuclear magnetic resonance imaging units housed in the Biomedical Imaging Center at the University of Tennessee Medical Center at Knoxville. In addition the UT -- DOE researchers actively collaborate with colleagues at other DOE facilities (Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory and Oak Ridge Associated Universities). An important goal of the DOE program at UT is to provide training for students (predoctoral and postdoctoral). The University of Tennessee is one of the very few institutions in the world where students have hands-on'' access to both modern scientific equipment and medical imaging modalities such as the clinical MRI units. The academic nature of the program facilitates collaborative interactions with other DOE programs and helps to insure the continued availability of skilled scientists dedicated to the advancement of diagnostic medical procedures. 14 refs., 3 figs.
International Nuclear Information System (INIS)
Harling, Otto K.
2009-01-01
Based on experience gained in the recent clinical studies at MIT/Harvard, the desirable characteristics of epithermal neutron irradiation facilities for eventual routine clinical BNCT are suggested. A discussion of two approaches to using fission reactors for epithermal neutron BNCT is provided. This is followed by specific suggestions for the performance and features needed for high throughput clinical BNCT. An example of a current state-of-the-art, reactor based facility, suited for routine clinical use is discussed. Some comments are provided on the current status of reactor versus accelerator based epithermal neutron sources for BNCT. This paper concludes with a summary and a few personal observations on BNCT by the author.
International Nuclear Information System (INIS)
Barth, R.F.; Yang, W.; Bartus, R.T.; Rotaru, J.H.; Ferketich, A.K.; Moeschberger, M.L.; Nawrocky, M.M.; Coderre, J.A.
2000-01-01
Cereport is a bradykinin analogue that produces a transient, pharmacologically mediated opening of the blood-brain barrier (BBB). The present study was designed to determine if Cereport could enhance the delivery of BPA and the efficacy of BNCT in nude rats bearing intracerebral implants of the human MRA 27 melanoma. Animals that received intracarotid (i.c.) injection of Cereport and i.c. BPA had a mean survival time of 115 d compared to 82 d without Cereport, 42 d for i.v. BPA with Cereport and 31 d for irradiated controls. The combination of i.c. Cereport and BPA produced a 400% increase in the life span with 35% long-term survivors (>180 d). (author)
Output Filter Design for a Novel Dual-Input PV-Wind Power Converter by Energy Balance Principle
Directory of Open Access Journals (Sweden)
Chih-Lung Shen
2016-09-01
Full Text Available In this paper, a detailed and systematic derivation of the output filter in a novel dual-input photovoltaic (PV-wind converter (DIPWC is presented. The theoretical derivation is based on an energy balance principle. While the DIPWC operates in steady state, the amount of charged energy of the output filter will be equal to that of the energy pumped away within one switching cycle. From this zero net change in energy, the minimum value of the output filter can be found. With the determined value, the DIPWC is able to operate in continuous conduction for high power applications. The developed procedure of the inductance determination can be applied to other types of dual-input converters. Therefore, it makes significant contributions to the design toward a green-energy, multi-input converter. To verify the correctness of the mathematical analysis, the DIPWC—with the derived output inductance—is built and tested. Practical measurements and results have verified the inductance determination.
Design of a novel photonic crystal fiber filter based on gold-coated and elliptical air holes
Zhao, Yunyan; Li, Shuguang; Liu, Qiang; Wang, Xinyu
2017-11-01
In recent years, photonic crystal fibers have played an important role in the field of optical communications, and the addition of metal materials to photonic crystal fibers have offered new ways to improve the transmission characteristics of optical fibers. We design a new type of gold-coated photonic crystal filter, which utilizes the surface plasmon resonance effect, and study it by using the finite element method. In this paper, we optimise the structure parameters and analyze the numerical results. The numerical results show that the thickness of metal layer and the air holes near the fiber core strongly affect the performance of the polarization filter. For the operating wavelength of 1550 nm, the loss in the y-polarization direction can be as high as 906.9 dB/cm, which is much larger than the x-polarization direction. When the fiber length is longer than 100 μm, the crosstalk in the wavelength range from 1.4 μm to 1.9 μm is greater than 20 dB. The proposed optical fiber can find application as an optical fiber polarization filter.
BNCT clinical trials of skin melanoma patients in Argentina
International Nuclear Information System (INIS)
Roth, Berta M.; Bonomi, Marcelo R.; Gonzalez, Sara J.
2006-01-01
The clinical outcome of six skin melanoma BNCT irradiations is presented. Three patients (A, B and C), with multiple subcutaneous skin metastases progressed to chemotherapy were infused with ∼14 g/m 2 of boronophenylalanine ( 10 BPA)-fructose and irradiated in the hyperthermal neutron beam of the RA-6 reactor. Patient A received two one fraction irradiations in different areas of the leg, B received one fraction and C was irradiated in three consecutive fields at the calf, heel and foot sole. The maximum prescribed dose to normal skin ranged from 16.5 to 24 Gy-Eq. With a minimum follow-up of 10 months there was a G1 acute epithelitis in A and B and a G3 in C. No late toxicity was observed. Due to the in-field tumor-growth-delay and the absence of severe acute and/or late toxicity observed during the follow-up period, a dose-escalation trial is ongoing. (author)
Liquid Li based neutron source for BNCT and science application.
Horiike, H; Murata, I; Iida, T; Yoshihashi, S; Hoashi, E; Kato, I; Hashimoto, N; Kuri, S; Oshiro, S
2015-12-01
Liquid lithium (Li) is a candidate material for a target of intense neutron source, heat transfer medium in space engines and charges stripper. For a medical application of BNCT, epithermal neutrons with least energetic neutrons and γ-ray are required so as to avoid unnecessary doses to a patient. This is enabled by lithium target irradiated by protons at 2.5 MeV range, with utilizing the threshold reaction of (7)Li(p,n)(7)Be at 1.88 MeV. In the system, protons at 2.5 MeV penetrate into Li layer by 0.25 mm with dissipating heat load near the surface. To handle it, thin film flow of high velocity is important for stable operation. For the proton accelerator, electrostatic type of the Schnkel or the tandem is planned to be employed. Neutrons generated at 0.6 MeV are gently moderated to epithermal energy while suppressing accompanying γ-ray minimum by the dedicated moderator assembly. Copyright © 2015 Elsevier Ltd. All rights reserved.
The Idaho Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program overview
International Nuclear Information System (INIS)
Dorn, R.V. III; Griebenow, M.L.; Ackermann, A.L.; Miller, L.G.; Miller, D.L.; Wheeler, F.J.; Bradshaw, K.M.; Wessol, D.E.; Harker, Y.D.; Nigg, D.W.; Randolph, P.D.; Bauer, W.F.; Gavin, P.R.; Richards, T.L.
1992-01-01
The Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program has been funded since 1988 to evaluate brain tumor treatment using Na 2 B 12 H 11 SH (borocaptate sodium or BSH) and epithermal neutrons. The PBF/BNCT Program pursues this goal as a comprehensive, multidisciplinary, multiorganizational endeavor applying modern program management techniques. The initial focus was to: (1) establish a representative large animal model and (2) develop the generic analytical and measurement capabilities require to control treatment repeatability and determine critical treatment parameters independent of tumor type and body location. This paper will identify the PBF/BNCT Program elements and summarize the status of some of the developed capabilities
Subcellular boron and fluorine distributions with SIMS ion microscopy in BNCT and cancer research
Energy Technology Data Exchange (ETDEWEB)
Subhash Chandra
2008-05-30
The development of a secondary ion mass spectrometry (SIMS) based technique of Ion Microscopy in boron neutron capture therapy (BNCT) was the main goal of this project, so that one can study the subcellular location of boron-10 atoms and their partitioning between the normal and cancerous tissue. This information is fundamental for the screening of boronated drugs appropriate for neutron capture therapy of cancer. Our studies at Cornell concentrated mainly on studies of glioblastoma multiforme (GBM). The early years of the grant were dedicated to the development of cryogenic methods and correlative microscopic approaches so that a reliable subcellular analysis of boron-10 atoms can be made with SIMS. In later years SIMS was applied to animal models and human tissues of GBM for studying the efficacy of potential boronated agents in BNCT. Under this grant the SIMS program at Cornell attained a new level of excellence and collaborative SIMS studies were published with leading BNCT researchers in the U.S.
Directory of Open Access Journals (Sweden)
Ahmad Nawwar
2016-01-01
Full Text Available This paper presents a comparison of three-dimensional simulation for concentrator photovoltaic module using two types of multi-junction solar cell. Each had its own range of spectral response and based on that range a thin film filter was developed for each case to reflect the unused spectral of the solar spectrum and allowed the desired spectrum to reach the solar cell. The thin film was deposited on a secondary optical element that was used to homogenize the irradiance distribution on the solar cell. A thermal simulation was conducted to compare the resulted decrease in cell temperature due to the use of the thin film for each case.
Design of a Wien filter type heavy ion beam probe system for the measurement of plasma potential
Energy Technology Data Exchange (ETDEWEB)
Fujita, Hideki; Adati, Keizo; Kumazawa, Ryuhei; Okamura, Shoichi; Sato, Teruyuki
1987-05-01
This paper describes the design of a Heavy Ion Beam Probe (HIBP) system to measure the two-dimensional plasma potential profile in the central mirror region of an open ended plasma confinement device (RFC-XX-M). This HIBP system incorporates three novel features. The first is a Wien filter-type guide field that reduces the required beam acceleration voltage. The second is a set of deflecting electrodes located at the exit position of the secondary ion beam that steers all secondary ions into the analyzer at the same angle. And the third is a new method of absolute calibration.
Design of a Wien Filter Type Heavy Ion Beam Probe System for the Measurement of Plasma Potential
Fujita, Hideki; Adati, Keizô; Kumazawa, Ryuhei; Okamura, Shoichi; Sato, Teruyuki
1987-05-01
This paper describes the design of a Heavy Ion Beam Probe (HIBP) system to measure the two-dimensional plasma potential profile in the central mirror region of an open ended plasma confinement device (RFC-XX-M). This HIBP system incorporates three novel features. The first is a Wien filter-type guide field that reduces the required beam acceleraltion voltage. The second is a set of deflecting electrodes located at the exit position of the secondary ion beam that steers all secondary ions into the analyzer at the same angle. And the third is a new method of absolute calibration.
Potchinkov, A.; Reemtsen, R.
1993-12-01
In [4,6], the authors have presented a numerical method for the solution of complex minimax problems, which implicitly solves discretized versions of the equivalent semi-infinite programming problem on increasingly finer grids. While this method only requires the most violated constraint at the current iterate on a finite subset of the infinitely many constraints of the problem, we consider here a related and more direct approach (applicable to general convex semi-infinite programming problems) which makes use of the globally most violated constraint. Numerical examples with up to 500 unknowns, which partially originate from digital filter design problems, are discussed.
Directory of Open Access Journals (Sweden)
Syifaul Fuada
2017-07-01
Full Text Available Visible Light Communication (VLC as one of wireless technology must be able to offer a good capability as mobile communication system. The signal will be faded when the distance and angle of LED to photo-detector become higher at a certain distance. Other problem at VLC system is light interference noise which is caused by flicker effect from other light sources such as incandescent, fluorescent, DC-lamp (i.e. flashlight and the sunlight. Each of lights have specific carried signal characteristics and it can influences the VLC system. In this paper we offer design of mobile VLC system based on analog domain. We use Automatic Gain Controller (AGC circuit using commercially available IC and it will be placed at analog front-end receiver side. AGC can self-adjust its gain according to the input signal amplitude. We also design analog filter to eliminate all interferences noise spectrum which is existed under 50 KHz. We design both circuits, analog filter and AGC in VLC receiver system with low-cost. The test data are obtained through the simulation and achieved good results in ideal condition.
Might iodomethyl-{alpha}-tyrosine be a surrogate for BPA in BNCT?
Energy Technology Data Exchange (ETDEWEB)
Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.
1996-12-31
A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with {sup 10}B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that {sup 10}B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing {sup 18}F-fluoroboronophenylaianine [FBPA] as a positron {sup 18}F (T{sub 1/2} = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of {sup 123}I alpha methyltyrosine as a surrogate for BPA in BNCT.
Might iodomethyl-α-tyrosine be a surrogate for BPA in BNCT?
International Nuclear Information System (INIS)
Miura, Michiko; Micca, P.L.; Nawrocky, M.M.; Slatkin, D.N.
1996-01-01
A single-photon emission computed tomography [SPECT] imaging agent that is an analogue of a boron carrier for boron neutron-capture therapy [BNCT] of cerebral gliomas would be useful for assessing the kinetics of boron uptake in tumors and in the surrounding brain tissues noninvasively. BNCT is based on the interaction of thermalized neutrons with 10 B nuclei in the targeted tumor. For BNCT of brain tumors, it is crucial that 10 B concentrations in radiosensitive regions of the brain be minimal since malignant cells and vital brain tissues are often inter-mingled at the margins of the tumor. Currently, boronophenylalanine [BPA]-mediated BNCT is undergoing preliminary clinical study for postoperative radiotherapy of glioblastorna multiforme at Brookhaven National Laboratory. Investigators in Japan are developing 18 F-fluoroboronophenylaianine [FBPA] as a positron 18 F (T 1/2 = 110 min), which is usually emission tomography [PET] surrogate for BPA. generated at a cyclotron dedicated to PET, is generally a minimally perturbing substitute for the 2-H on the aromatic ring because of its small size and the strong covalent bond it forms with carbon. However, SPECT has potential advantages over PET: (1) SPECT is clinically more widely available at lower cost; (2) most radioisotopes for the synthesis of SPECT agents can be purchased; (3) SPECT is less difficult to implement. It is thought that the quality of images derived from the two techniques would each be sufficiently informative for BNCT treatment planning purposes, provided that the SPECT and PET agents being considered were both pharmacokinetic surrogates for BPA. This study evaluated the use of 123 I alpha methyltyrosine as a surrogate for BPA in BNCT
Yan, Gang; Xu, Xia; Yao, Lirong; Lu, Liqiao; Zhao, Tingting; Zhang, Wenyi
2011-04-01
As one of the plug-flow reactors, biological aerated filter (BAF) reactor was divided into four sampling sectors to understand the characteristics of elemental nitrogen transformation during the reaction process, and then the different characteristics of elemental nitrogen transformation caused by different NH(3)-N loadings, biological quantities and activities in each section were obtained. The results showed that the total transformation ratio in the nitrifying reactor was more than 90% in the absence of any organic carbon resource, at the same time, more than 65% NH(3)-N in the influent were nitrified at the filter height of 70 cm below under the conditions of the influent runoff 9-19 L/h, the gas-water ratio 4-5:1, the dissolved oxygen 3.0-5.8 mg/L and the NH(3)-N load 0.28-0.48 kg NH(3)-N/m(3) d. On the base of the Eckenfelder mode, the kinetics equation of the NH(3)-N transformation along the reactor was S(e)=S(0) exp(-0.0134D/L(1.2612)). Copyright © 2011 Elsevier Ltd. All rights reserved.
Hariyadi, T.; Mulyasari, S.; Mukhidin
2018-02-01
In this paper we have designed and simulated a Band Pass Filter (BPF) at X-band frequency. This filter is designed for X-band weather radar application with 9500 MHz center frequency and bandwidth -3 dB is 120 MHz. The filter design was performed using a hairpin microstrip combined with an open stub and defected ground structure (DGS). The substrate used is Rogers RT5880 with a dielectric constant of 2.2 and a thickness of 1.575 mm. Based on the simulation results, it is found that the filter works on frequency 9,44 - 9,56 GHz with insertion loss value at pass band is -1,57 dB.
Directory of Open Access Journals (Sweden)
Sopida Sungsoontorn
2016-08-01
Full Text Available A doubly corrugated filter was designed for a combined multi-feed microwave-hot air and continuous belt system (CMCB. The proposed filter reduces microwave energy radiation from the open entry of the continuous belt system. Microwave radiation leakage that affects a human should remain below 10 mW/cm2. The filter was designed for stop-band frequency range 2,300-2,600 MHz, while the operating frequency is 2,450 MHz, and for attenuation greater than 60 dB in this range. We report on optimizing all the design parameters of a doubly corrugated filter and on experimental verification after its installation at the Research Center of Microwave Utilization in Engineering (R.C.M.E at Thammasat University, Thailand.
Liposome and co-spray-dried PVP / o-carborane formulations for BNCT treatment of cancer
Olusanya, Temidayo; Stich, Theresia; Higgins, Samantha Caroline; Lloyd, Rhiannon Eleanor Iris; Pilkington, Geoffrey John; Fatouros, Dimitrios; Calabrese, Gianpiero; Smith, James Richard; Tsibouklis, John
2015-01-01
Purpose: Boron neutron capture therapy (BNCT) is a method for selectively destroying malignant (normally glioma) cells whilst sparing normal tissue. Irradiation of 10B (large neutron capture cross-section) with thermal neutrons effects the nuclear fission reaction: 10B + 1n → → 7Li+ + α + γ; where the penetration of α-particles and 7Li+ is only 8 and 5 µm, respectively, i.e., within a single cell thickness. Poor selectivity is the main reason why BNCT has not become a mainstream cancer therap...
The Boron Neutron Capture Therapy (BNCT) Project at the TRIGA Reactor in Mainz, Germany
DEFF Research Database (Denmark)
Hampel, G.; Grunewald, C.; Schütz, C.
2011-01-01
The thermal column of the TRIGA reactor in Mainz is being used very effectively for medical and biological applications. The BNCT (boron neutron capture therapy) project at the University of Mainz is focussed on the treatment of liver tumours, similar to the work performed at Pavia (Italy) a few...... have also been initiated to investigate radiobiological effects of radiation generated during BNCT. For both experiments and treatment, a reliable dosimetry system is necessary. From work elsewhere, the use of alanine detectors appear to be an appropriate dosimetry technique....