WorldWideScience

Sample records for blood standard system

  1. Blood groups systems

    OpenAIRE

    Ranadhir Mitra; Nitasha Mishra; Girija Prasad Rath

    2014-01-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importa...

  2. Blood Donation Management System

    OpenAIRE

    K M Akkas Ali; Israt Jahan; Md. Ariful Islam; Md. Shafa-at Parvez

    2015-01-01

    This paper is focused on Blood Donation Management System which is a web application with supporting mobile application aimed to serve as a communication tool between patients (who need blood) and blood donor. To become members of the system, donors need to create their profiles by providing fundamental information like name, blood group, email address, password, and exact location from “Google Map”. In order to find out the exact location of a donor, Google Map is integrated with this app...

  3. Blood groups systems

    Directory of Open Access Journals (Sweden)

    Ranadhir Mitra

    2014-01-01

    Full Text Available International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system.

  4. Blood groups systems.

    Science.gov (United States)

    Mitra, Ranadhir; Mishra, Nitasha; Rath, Girija Prasad

    2014-09-01

    International Society of Blood Transfusion has recently recognized 33 blood group systems. Apart from ABO and Rhesus system, many other types of antigens have been noticed on the red cell membranes. Blood grouping and cross-matching is one of the few important tests that the anaesthesiologist orders during perioperative period. Hence, a proper understanding of the blood group system, their clinical significance, typing and cross-matching tests, and current perspective are of paramount importance to prevent transfusion-related complications. Nonetheless, the knowledge on blood group system is necessary to approach blood group-linked diseases which are still at the stage of research. This review addresses all these aspects of the blood groups system. PMID:25535412

  5. Blood Donation Management System

    Directory of Open Access Journals (Sweden)

    K M Akkas Ali

    2015-06-01

    Full Text Available This paper is focused on Blood Donation Management System which is a web application with supporting mobile application aimed to serve as a communication tool between patients (who need blood and blood donor. To become members of the system, donors need to create their profiles by providing fundamental information like name, blood group, email address, password, and exact location from “Google Map”. In order to find out the exact location of a donor, Google Map is integrated with this application. The mobile application always updates the location of a donor. As a result, the system can automatically find a registered donor wherever he/she goes. Visitors can search blood donors from the home page by blood group and the place where blood is needed. The system will show the available donors along with their phone number, email address and mailing address through arranging them by nearest place and blood donation expire date. Visitors can send message to all donors through email but a member can send message using email and mobile phone. An appointment will be created only whenever a donor confirms that he/she will donate blood. Then the system will alert the donor before 12 hours of donation. Blood donors can also be searched from the mobile application, but this is only accessible for registered members. The goal of this paper is to reduce the complexity of the system to find blood donors in an emergency situation.

  6. ISO 9000 quality standards: a model for blood banking?

    Science.gov (United States)

    Nevalainen, D E; Lloyd, H L

    1995-06-01

    The recent American Association of Blood Banks publications Quality Program and Quality Systems in the Blood Bank and Laboratory Environment, the FDA's draft guidelines, and recent changes in the GMP regulations all discuss the benefits of implementing quality systems in blood center and/or manufacturing operations. While the medical device GMPs in the United States have been rewritten to accommodate a quality system approach similar to ISO 9000, the Center for Biologics Evaluation and Research of the FDA is also beginning to make moves toward adopting "quality systems audits" as an inspection process rather than using the historical approach of record reviews. The approach is one of prevention of errors rather than detection after the fact (Tourault MA, oral communication, November 1994). The ISO 9000 series of standards is a quality system that has worldwide scope and can be applied in any industry or service. The use of such international standards in blood banking should raise the level of quality within an organization, among organizations on a regional level, within a country, and among nations on a worldwide basis. Whether an organization wishes to become registered to a voluntary standard or not, the use of such standards to become ISO 9000-compliant would be a move in the right direction and would be a positive sign to the regulatory authorities and the public that blood banking is making a visible effort to implement world-class quality systems in its operations. Implementation of quality system standards such as the ISO 9000 series will provide an organized approach for blood banks and blood bank testing operations. With the continued trend toward consolidation and mergers, resulting in larger operational units with more complexity, quality systems will become even more important as the industry moves into the future.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7770906

  7. Comparison of a New Miniaturized Extracorporeal Membrane Oxygenation System With Integrated Rotary Blood Pump to a Standard System in a Porcine Model of Acute Lung Injury.

    Science.gov (United States)

    Pilarczyk, Kevin; Heckmann, Jens; Lyskawa, Kathrin; Strauß, Andreas; Haake, Nils; Wiese, Ingo; Jakob, Heinz; Kamler, Markus; Pizanis, Nikolaus

    2016-07-01

    Extracorporeal membrane oxygenation (ECMO) is used for severe acute respiratory distress syndrome. However, available ECMO systems are large and not well designed for fast delivery, emergency implantation, and interhospital transfer. Therefore, a new miniaturized oxygenator with integrated rotary blood pump (ILIAS) was developed and compared with a standard ECMO system in a large animal model. Acute lung injury was induced with repeated pulmonary saline lavage in 14 pigs until PaO2 /FiO2 -ratio was <100 mm Hg with a positive-end-expiratory-pressure of 5 mbar. Pigs were assigned to the following three groups: group 1 (n = 4): control group with conventional ventilation; group 2 (n = 5): standard vv-ECMO; group 3 (n = 5): vv-ILIAS. Gas exchange, hemodynamics, hemolysis, and coagulation activation were examined over a period of 8 h. No device failed during the observation period. PaCO2 decreased from 59.40 ± 4.14 mm Hg to 48.62 ± 4.50 mm Hg after 1 h in the ILIAS group compared with an improvement of PaCO2 from 48.86 ± 7.45 to 40.10 ± 6.02 in the conventional ECMO group (P = not significant [n.s.]). ARDS-induced respiratory acidosis was controlled promptly with a pH of 7.2 ± 0.1 at baseline increasing to 7.4 ± 0.1 in both study groups after 60 min of ECMO support. Mean carbon dioxide transfer was comparable between the conventional ECMO and ILIAS (211.36 ± 78.39 mL/min vs. 219.99 ± 76.72 mL/min, P = n.s.). PaO2 /FiO2 increased from 118.4 ± 15.5 mm Hg to 179.1 ± 72.4 mm Hg in the ILIAS group compared with an improvement of oxygenation from 107.1 ± 24.9 mm Hg to 179.0 ± 45.7 mm Hg in the standard ECMO group (P = n.s.). Mean oxygen transfer was calculated with 136.09 ± 30.25 mL/min for the ILIAS and 129.05 ± 36.28 mL/min for the standard ECMO. Hemodynamic instability or significant activation of the plasmatic coagulation was not

  8. Standard Blood Pressure Target is Sufficient for Treating Some Strokes

    Science.gov (United States)

    ... News Releases News Release Wednesday, June 8, 2016 Standard blood pressure target is sufficient for treating some ... of Minnesota An international stroke study found that standard and intensive blood pressure treatments were equally effective ...

  9. Blood Pump Bearing System

    Science.gov (United States)

    Aber, Gregory S. (Inventor)

    2000-01-01

    An apparatus is provided for a blood pump bearing system within a pump housing to support long-term highspeed rotation of a rotor with an impeller blade having a plurality of individual magnets disposed thereon to provide a small radial air gap between the magnets and a stator of less than 0.025 inches. The bearing system may be mounted within a flow straightener, diffuser, or other pump element to support the shaft of a pump rotor. The bearing system includes a zirconia shaft having a radiused end. The radiused end has a first radius selected to be about three times greater than the radius of the zirconia shaft. The radiused end of the zirconia shaft engages a flat sapphire endstone. Due to the relative hardness of these materials a flat is quickly produced during break-in on the zirconia radiused end of precisely the size necessary to support thrust loads whereupon wear substantially ceases. Due to the selection of the first radius, the change in shaft end-play during pump break-in is limited to a total desired end-play of less than about 0.010 inches. Radial loads are supported by an olive hole ring jewel that makes near line contact around the circumference of the Ir shaft to support big speed rotation with little friction. The width of olive hole ring jewel is small to allow heat to conduct through to thereby prevent heat build-up in the bearing. A void defined by the bearing elements may fill with blood that then coagulates within the void. The coagulated blood is then conformed to the shape of the bearing surfaces.

  10. Standard NIM instrumentation system

    CERN Document Server

    1990-01-01

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID- 20893 (Rev 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice.

  11. Standard NIM instrumentation system

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-01

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID-20893 (Rev. 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice.

  12. Standard NIM instrumentation system

    International Nuclear Information System (INIS)

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID-20893 (Rev. 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice

  13. Automated microscopy system for peripheral blood cells

    Science.gov (United States)

    Boev, Sergei F.; Sazonov, Vladimir V.; Kozinets, Gennady I.; Pogorelov, Valery M.; Gusev, Alexander A.; Korobova, Farida V.; Vinogradov, Alexander G.; Verdenskaya, Natalya V.; Ivanova, Irina A.

    2000-11-01

    The report describes the instrument ASPBS (Automated Screening of Peripheral Blood Cells) designed for an automated analysis of dry blood smears. The instrument is based on computer microscopy and uses dry blood smears prepared according to the standard Romanovskii-Giemza procedure. In comparison with the well-known flow cytometry systems, our instrument provides more detailed information and offers an opporunity of visualizing final results. The basic performances of the instrument are given. Software of this instrument is based on digital image processing and image recognition procedures. It is pointed out that the instrument can be used as a fairly universal tool in scientific research, public demonstrations, in medical treatment, and in medical education. The principle used as the basis of the instrument appeared adequate for creating an instrument version serviceable even during space flights where standard manual procedures and flow cytometry systems fail. The benefit of the use of the instrument in clinical laboratories is described.

  14. Finger prick blood plasma separation using a standard lab equipment

    DEFF Research Database (Denmark)

    Kwasny, Dorota; Andersen, Karsten Brandt; Pfreundt, Andrea;

    . Here we present a device for analysis of minute blood volumes using a standard laboratory tabletop spinner. The microfabricated polymer device fits in a 1.5 mL eppendorf tube and takes between 10-20 μl of whole blood. The blood is layered over a pre-loaded Ficoll paque® that is used to separate the...... separation the plasma and white blood cells are simply pipetted or pushed out of the device by pressing a flexible chamber. Plasma quality is assessed by spectrophotometry to determine the amount of proteins in the extracted plasma and the degree of undesired hemolysis....

  15. 32 CFR 634.34 - Blood alcohol concentration standards.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Blood alcohol concentration standards. 634.34 Section 634.34 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW... alcohol concentration standards. (a) Administrative revocation of driving privileges and other...

  16. Endovascular blood flow measurement system

    Science.gov (United States)

    Khe, A. K.; Cherevko, A. A.; Chupakhin, A. P.; Krivoshapkin, A. L.; Orlov, K. Yu

    2016-06-01

    In this paper an endovascular measurement system used for intraoperative cerebral blood flow monitoring is described. The system is based on a Volcano ComboMap Pressure and Flow System extended with analogue-to-digital converter and PC laptop. A series of measurements performed in patients with cerebrovascular pathologies allows us to introduce “velocity-pressure” and “flow rate-energy flow rate” diagrams as important characteristics of the blood flow. The measurement system presented here can be used as an additional instrument in neurosurgery for assessment and monitoring of the operation procedure. Clinical data obtained with the system are used for construction of mathematical models and patient-specific simulations. The monitoring of the blood flow parameters during endovascular interventions was approved by the Ethics Committee at the Meshalkin Novosibirsk Research Institute of Circulation Pathology and included in certain surgical protocols for pre-, intra- and postoperative examinations.

  17. Flight Standards Automation System

    Data.gov (United States)

    Department of Transportation — FAVSIS supports Flight Standards Service (AFS) by maintaining their information on entities such as air carriers, air agencies, designated airmen, and check airmen....

  18. The Indian blood group system.

    Science.gov (United States)

    Xu, Q

    2011-01-01

    The Indian blood group system (ISBT: IN/023) consists of two antithetical antigens: In(a) (IN1), which is present in approximately 10 percent of some Arab populations and in 3 percent of Bombay Indians, and its allelic antigen In(b) (IN2), an antigen of high incidence in all populations. In 2007, two new high-incidence antigens were identified as belonging to the IN blood group system, namely IN3 (INFI) and IN4 (INJA). The antigens in this system are located on CD44, a single-pass membrane glycoprotein that is encoded by the CD44 gene on chromosome 11 at position p13. The biologic function of CD44 is as a leukocyte homing receptor and cellular adhesion molecule. The In(a) and In(b) polymorphism represents a 252G>C substitution of CD44, encoding R46P, and lack of IN3 and IN4 results from homozygosity for mutations encoding H85Q and T163R in the CD44 gene. The high-frequency antigen AnWj (901009) has not been assigned to the Indian system, but either is located on an isoform of CD44 or is closely associated with it.

  19. [Mobile Health: IEEE Standard for Wearable Cuffless Blood Pressure Measuring Devices].

    Science.gov (United States)

    Zhou, Xia; Wu, Wenli; Bao, Shudi

    2015-07-01

    IEEE Std 1708-2014 breaks through the traditional standards of cuff based blood pressure measuring devices and establishes a normative definition of wearable cuffless blood pressure measuring devices and the objective performance evaluation of this kind of devices. This study firstly introduces the background of the new standard. Then, the standard details will be described, and the impact of cuffless blood pressure measuring devices with the new standard on manufacturers and end users will be addressed.

  20. A Blood Bank Information Management System

    Science.gov (United States)

    Farmer, James J.

    1982-01-01

    A computerized Blood Bank Management system is described. Features include product oriented data input, inventory control reports, product utilization reports, rapid retrieval of individual patient reports. Relative benefits of the system are discussed.

  1. Non-Standard Numeration Systems

    Directory of Open Access Journals (Sweden)

    P. Ambrož

    2005-01-01

    Full Text Available We study some properties of non-standard numeration systems with an irrational base ß >1, based on the so-called beta-expansions of real numbers [1]. We discuss two important properties of these systems, namely the Finiteness property, stating whether the set of finite expansions in a given system forms a ring, and then the problem of fractional digits arising under arithmetic operations with integers in a given system. Then we introduce another way of irrational representation of numbers, slightly different from classical beta-expansions. Here we restrict ourselves to one irrational base – the golden mean ? – and we study the Finiteness property again. 

  2. SYSTEMIC BLOOD ACTIVATION DURING AND AFTER AUTOTRANSFUSION

    NARCIS (Netherlands)

    SCHONBERGER, JPAM; VANOEVEREN, W; BREDEE, JJ; EVERTS, PAM; DEHAAN, J; WILDEVUUR, CRH

    1994-01-01

    To evaluate the extent of shed blood activation in two autotransfusion systems and the effect of circulating blood activation upon autotransfusion, we performed a prospective study in 18 patients undergoing internal mammary artery bypass operation and a control group of 10 patients. The autotransfus

  3. Blood monitoring systems and methods thereof

    Science.gov (United States)

    Mir, Jose (Inventor); Zander, Dennis (Inventor)

    2012-01-01

    A blood monitoring system is capable of monitoring the blood of a subject in vivo. The blood monitoring system comprises: 1) an array of movable microneedle micromachined within associated wells; 2) array of motion actuators able to move each needle in and out of their associated wells; 3) array of microvalves associated with each microneedle able to control the flow of air around the microneedle; 4) an array of chemical sensors inserted into patient by movable microneedles; 5) an array of inductors able to measure chemical concentration in the vicinity of inserted chemical sensors; 6) conducting vias that provide timed actuating signal signals from a control system to each motion actuator; 7) conducting vias that transmit signal produced by array of chemical sensors to the control system for processing, although the blood monitoring system can comprise other numbers and types of elements in other configurations.

  4. Integrated Standardization and Systems Engineering Management

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Integrated standardization is one of the fundamenta l forms of modern standardization. It is the combination of system science and the content of standardization. The development of system science has provided theo retic foundation and precondition for integrated standardization. The relevant r esearch on integrated standardization and system engineering illustrate that int egrated standardization is a advanced method which presented with the developmen t of modern science and technology . Integrated st...

  5. Influence of Blood Collection Systems on Coagulation Tests

    Directory of Open Access Journals (Sweden)

    Soner Yavaş

    2012-12-01

    Full Text Available OBJECTIVE: Coagulation tests are influenced by pre-analytic conditions such as blood collection systems. Change of glass collection tubes with plastic ones will cause alteration of the test results. The aim of this study was to compare three plastic blood collection tubes with a standard glass blood collection tube and each plastic collection tube with the other two for possible additional tube-to- tube differences. METHODS: A total of 284 blood samples were obtained from 42 patients receiving warfarin during their routine controls, besides 29 healthy volunteers. Subgroup analyses were done according to health status. RESULTS: Our study demonstrated that different blood collection tubes have a statistically significant influence on coagulation tests. The magnitude of the effect depends on the tube used. However most of the tests performed on samples obtained from any tube correlated significantly with results obtained from other tube samples. CONCLUSION: Although blood collection tubes with different brands or properties will have distinct effects on coagulation tests, the influence of these blood collection tubes may be relatively small to interfere with decision-making on dose prescription, therefore lack clinical importance. Correlations between the results showed that, one of these plastic blood collection tubes tested in our study, can be used interchangably for a wide variety of coagulation assays.

  6. IBCIS:Intelligent blood cell identification system

    Institute of Scientific and Technical Information of China (English)

    Adnan Khashman

    2008-01-01

    The analysis of blood cells in microscope images can provide useful information concerning the health of patients.There are three major blood cell types,namely,erythrocytes (red),leukocytes (white),and platelets.Manual classification is time consuming and susceptible to error due to the different morphological features of the cells.This paper presents an intelligent system that simulates a human visual inspection and classification of the three blood cell types.The proposed system comprises two phases:The image preprocessing phase where blood cell features are extracted via global pattern averaging,and the neural network arbitration phase where training is the first and then classification is carried out.Experimental results suggest that the proposed method performs well in identifying blood cell types regardless of their irregular shapes,sizes and orientation,thus providing a fast,simple and efficient rotational and scale invariant blood cell identification system which can be used in automating laboratory reporting.

  7. Design of a blood-freezing system for leukemia research

    Science.gov (United States)

    Williams, T. E.; Cygnarowicz, T. A.

    1978-01-01

    Leukemia research involves the use of cryogenic freezing and storage equipment. In a program being carried out at the National Cancer Institute (NCI), bone marrow (white blood cells) was frozen using a standard cryogenic biological freezer. With this system, it is difficult to maintain the desired rate of freezing and repeatability from sample to sample. A freezing system was developed that satisfies the requirements for a repeatable, constant freezing rate. The system was delivered to NIC and is now operational. This report describes the design of the major subsystems, the analyses, the operating procedure, and final system test results.

  8. Development of standard definitions for surveillance of complications related to blood donation.

    Science.gov (United States)

    Goldman, M; Land, K; Robillard, P; Wiersum-Osselton, J

    2016-02-01

    Standard definitions of donor reactions allow each blood establishment to monitor donor adverse events and compare with other organizations to develop best practices. The ISBT Haemovigilance Working Party leads a multi-organizational effort to update the 2008 ISBT standard for surveillance of complications related to blood donation. Revised definitions have been developed and endorsed by the ISBT, AABB, International Haemovigilance Network (IHN) and other international organizations. PMID:26361365

  9. An Analysis of and Recommendations for the Peruvian Blood Collection and Transfusion System

    Science.gov (United States)

    George, Paul E; Vidal, Julio; Garcia, Patricia J

    2016-01-01

    Background Peru experienced a crisis in its blood collection and supply system in the mid-2000s, as contaminated blood led to several transfusion-transmitted infections (TTI), occurring in the backdrop of extremely low voluntary donation rates and a national blood supply shortage. Thus, the Peruvian Ministry of Health (MINSA) implemented a national investigation on the safety and quality of the Peruvian blood collection/transfusion network. Methods Every Peruvian blood bank was evaluated by MINSA from 2007–2008. These evaluations consisted of an update of the national registry of blood banks and visits to each blood bank from MINSA oversight teams. Information was collected on the condition of the blood bank personnel, equipment, supplies, and practices. Further, previously-collected blood at each blood bank was randomly selected and screened for TTI-causing pathogens. Results Uncovered in this investigation was a fragmented, under-equipped, and poorly-staffed blood collection and transfusion network, consisting of 241 independent blood banks and resulting in suboptimal allocation of resources. Further, blood with evidence of TTI-causing pathogens (including Hepatitis B, Hepatitis C, and syphilis) and set for transfusion was discovered at three separate blood banks as part of the random screening process. Conclusion Using the successful reorganizations of national blood supply systems in other Latin American countries as examples, Peru would be well-served to form large, high-volume, regional blood collection and transfusion centers, responsible for blood collection and screening for the entire country. The small, separate blood banks would then be transformed into a network of blood transfusion centers, not responsible for blood collection. This reorganization would allow Peru to better utilize its resources, standardize the blood collection and transfusion process, and increase voluntary donation, resulting in a safer, more abundant national blood product.

  10. Prions and the blood and immune systems.

    Science.gov (United States)

    Mabbott, Neil; Turner, Marc

    2005-04-01

    Prion diseases take a number of forms in animals and humans. They are caused by conformational change in widely expressed prion protein leading to the formation of intracellular aggregates. Although the main focus of disease is the central nervous system, it is known that involvement of the immune system occurs in peripherally transmitted disease in particular. Animal experiments suggest that in some prion diseases follicular dendritic cells in the germinal centers are a major site of initial accumulation, and that abnormal prion protein and infectivity are detectable in peripheral lymphoid tissue from the earliest phase of disease. This raises the possibility that in a human peripherally transmitted prion disease like variant Creutzfeldt-Jakob disease, further transmission could occur through blood or tissue products or contamination of surgical instrumentation. Indeed two recent reports confirm that this disease has been transmitted by blood, raising significant public health concerns. PMID:15820951

  11. Kidd blood group system: a review.

    Science.gov (United States)

    Hamilton, Janis R

    2015-01-01

    The Kidd blood group system has been recognized as clinically important in red blood cell (RBC) serology since its identification in 1951. Forty years later, the JK glycoprotein was determined to be a product of SCL14A1 and was identical to the urea transport protein UT-B produced by HUT11A. The functional role of the protein as a urea transporter in RBC and kidney has been well documented. The polymorphism responsible for the antithetical anigens Jk(a) and Jk(b) was identified in 1994 as c.838G>A (p.Asp280Asn). Recent discoveries have expanded the system to include 23 variant alleles recognized by the International Society of Blood Transfusion that silence the protein expression and 7 variant alleles presumably producting weak or partia JK antigens. Null phenotypes have been identified in individuals of several populations including those of African, Indian, and Chinese decent, in addition to the well-documented findings in the Polynesian and Finnish populations. This review will examine the historical information about the anigens and antibodies of the JK system as well as catalog the variations of the JK gene. PMID:26308468

  12. 75 FR 71625 - System Restoration Reliability Standards

    Science.gov (United States)

    2010-11-24

    ... Reliability Standards for the Bulk-Power System, Order No. 693, 72 FR 16416 at P 297 (Apr. 4, 2007), FERC... No. 486, 52 FR 47897 (Dec. 17, 1987), FERC Stats. & Regs. ] 30,783 (1987). \\34\\ 18 CFR 380.4(a)(5... Energy Regulatory Commission 18 CFR Part 40 System Restoration Reliability Standards November 18,...

  13. 21 CFR 862.1130 - Blood volume test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood volume test system. 862.1130 Section 862...) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems § 862.1130 Blood volume test system. (a) Identification. A blood volume test system is a device intended...

  14. Reconfigurable radio systems network architectures and standards

    CERN Document Server

    Iacobucci, Maria Stella

    2013-01-01

    This timely book provides a standards-based view of the development, evolution, techniques and potential future scenarios for the deployment of reconfigurable radio systems.  After an introduction to radiomobile and radio systems deployed in the access network, the book describes cognitive radio concepts and capabilities, which are the basis for reconfigurable radio systems.  The self-organizing network features introduced in 3GPP standards are discussed and IEEE 802.22, the first standard based on cognitive radio, is described. Then the ETSI reconfigurable radio systems functional ar

  15. Control Systems Cyber Security Standards Support Activities

    Energy Technology Data Exchange (ETDEWEB)

    Robert Evans

    2009-01-01

    The Department of Homeland Security’s Control Systems Security Program (CSSP) is working with industry to secure critical infrastructure sectors from cyber intrusions that could compromise control systems. This document describes CSSP’s current activities with industry organizations in developing cyber security standards for control systems. In addition, it summarizes the standards work being conducted by organizations within the sector and provides a brief listing of sector meetings and conferences that might be of interest for each sector. Control systems cyber security standards are part of a rapidly changing environment. The participation of CSSP in the development effort for these standards has provided consistency in the technical content of the standards while ensuring that information developed by CSSP is included.

  16. Ultrasound systems for blood velocity estimation

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt

    1998-01-01

    Medical ultrasound scanners can be used both for displayinggray-scale images of the anatomy and for visualizing theblood flow dynamically in the body.The systems can interrogate the flow at a single position in the bodyand there find the velocity distribution over time. They can also show adynamic...... color image of velocity at up to 20 to 60 frames a second. Both measurements are performedby repeatedly pulsing in the same direction and then usethe correlation from pulse to pulse to determine the velocity.The paper gives a simple model for the interactionbetween the ultrasound and the moving blood...

  17. Information systems support for OR product standardization.

    Science.gov (United States)

    Faetanini, C

    1994-02-01

    A critical reason why many healthcare institutions cannot effectively standardize OR products is that they cannot access necessary information. An OR information system that manages, tracks and generates documentation on OR inventory is an important answer to implementing change. At least four key areas any information system should address in order to make standardization a reality are 1) clinical preference, 2) supplying a changing case mix, 3) product usage data and 4) vendor performance. OR information systems operate on various hardware platforms. Users have more software choices than ever before, because connectivity issues have been effectively solved through the development of standard electronic transaction sets. PMID:10131895

  18. Particle swarm optimization algorithm for optimizing assignment of blood in blood banking system.

    Science.gov (United States)

    Olusanya, Micheal O; Arasomwan, Martins A; Adewumi, Aderemi O

    2015-01-01

    This paper reports the performance of particle swarm optimization (PSO) for the assignment of blood to meet patients' blood transfusion requests for blood transfusion. While the drive for blood donation lingers, there is need for effective and efficient management of available blood in blood banking systems. Moreover, inherent danger of transfusing wrong blood types to patients, unnecessary importation of blood units from external sources, and wastage of blood products due to nonusage necessitate the development of mathematical models and techniques for effective handling of blood distribution among available blood types in order to minimize wastages and importation from external sources. This gives rise to the blood assignment problem (BAP) introduced recently in literature. We propose a queue and multiple knapsack models with PSO-based solution to address this challenge. Simulation is based on sets of randomly generated data that mimic real-world population distribution of blood types. Results obtained show the efficiency of the proposed algorithm for BAP with no blood units wasted and very low importation, where necessary, from outside the blood bank. The result therefore can serve as a benchmark and basis for decision support tools for real-life deployment.

  19. Particle Swarm Optimization Algorithm for Optimizing Assignment of Blood in Blood Banking System

    Directory of Open Access Journals (Sweden)

    Micheal O. Olusanya

    2015-01-01

    Full Text Available This paper reports the performance of particle swarm optimization (PSO for the assignment of blood to meet patients’ blood transfusion requests for blood transfusion. While the drive for blood donation lingers, there is need for effective and efficient management of available blood in blood banking systems. Moreover, inherent danger of transfusing wrong blood types to patients, unnecessary importation of blood units from external sources, and wastage of blood products due to nonusage necessitate the development of mathematical models and techniques for effective handling of blood distribution among available blood types in order to minimize wastages and importation from external sources. This gives rise to the blood assignment problem (BAP introduced recently in literature. We propose a queue and multiple knapsack models with PSO-based solution to address this challenge. Simulation is based on sets of randomly generated data that mimic real-world population distribution of blood types. Results obtained show the efficiency of the proposed algorithm for BAP with no blood units wasted and very low importation, where necessary, from outside the blood bank. The result therefore can serve as a benchmark and basis for decision support tools for real-life deployment.

  20. Nocturnal variations in peripheral blood flow, systemic blood pressure, and heart rate in humans

    DEFF Research Database (Denmark)

    Sindrup, J H; Kastrup, J; Christensen, H;

    1991-01-01

    Subcutaneous adipose tissue blood flow rate, together with systemic arterial blood pressure and heart rate under ambulatory conditions, was measured in the lower legs of 15 normal human subjects for 12-20 h. The 133Xe-washout technique, portable CdTe(Cl) detectors, and a portable data storage unit...... were used for measurement of blood flow rates. An automatic portable blood pressure recorder and processor unit was used for measurement of systolic blood pressure, diastolic blood pressure, and heart rate every 15 min. The change from upright to supine position at the beginning of the night period...... was associated with a 30-40% increase in blood flow rate and a highly significant decrease in mean arterial blood pressure and heart rate (P less than 0.001 for all). Approximately 100 min after the subjects went to sleep an additional blood flow rate increment (mean 56%) and a simultaneous significant decrease...

  1. Practices around Customization of Standard Systems

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; Vaucouleur, Sebastien

    2008-01-01

    More and more software systems are developed by customizing a standard product that provide the major part of the functionality. The customization of Enterprise Resource Planning systems is such a product based software development practice. Little empirical research on the specificities of these......More and more software systems are developed by customizing a standard product that provide the major part of the functionality. The customization of Enterprise Resource Planning systems is such a product based software development practice. Little empirical research on the specificities...

  2. 21 CFR 864.9145 - Processing system for frozen blood.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Processing system for frozen blood. 864.9145 Section 864.9145 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... system for frozen blood is a device used to glycerolize red blood cells prior to freezing to...

  3. Development of blood extraction system for health monitoring system

    Science.gov (United States)

    Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Nakamachi, Eiji

    2004-03-01

    The purpose of this research is to develop the compact human blood sampling device applied for a health monitoring system(HMS), which is called "Mobile Hospital". The HMS consists of (1) a micro electrical pumping system for blood extraction, (2) a bio-sensor to detect and evaluate an amount of Glucose, Cholesterol and Urea in extracted blood, by using enzyme such as Glucoseoxidase (GOD), Cholesteroloxidase and Urease. The mechanical design elements of the device are bio-compatible microneedle, indentation unit using a shape memory alloy(SMA) actuator and pumping unit using a piezoelectric microactuator. The design concept is the biomimetic micromachine of female mosquito"s blood sampling mechanism. The performances of the main mechanical elements such as indentation force of the microneedle, actual stroke of the indentation unit using a SMA actuator and liquid sampling ability of the pumping unit using PZT piezoelectric microactuator were measured. The 3 mm stroke of the indentation load generated by SMA actuator was 0.8mN. The amount of imitation blood extracted by using bimorph PZT actuators was about 0.5 microliters for 10 sec. A 60-micrometer outer diameter and 25-micrometer inner diameter Titanium microneedle, which size is same as female mosquito"s labium, was produced by sputter deposition.

  4. System accuracy of blood glucose monitoring systems: impact of use by patients and ambient conditions.

    Science.gov (United States)

    Schmid, Christina; Haug, Cornelia; Heinemann, Lutz; Freckmann, Guido

    2013-10-01

    For self-monitoring of blood glucose by people with diabetes, the reliability of the measured blood glucose values is a prerequisite in order to ensure correct therapeutic decisions. Requirements for system accuracy are defined by the International Organization for Standardization (ISO) in the standard EN ISO 15197:2003. However, even a system with high analytical quality is not a guarantee for accurate and reliable measurement results. Under routine life conditions, blood glucose measurement results are affected by several factors. First, the act of performing measurements as well as the handling of the system may entail numerous possible error sources, such as traces of glucose-containing products on the fingertips, the use of deteriorated test strips, or the incorrect storage of test strips. Second, ambient and sampling conditions such as high altitude, partial pressure of oxygen, ambient temperature, and the use of alternate test sites can have an influence on measurement results. Therefore, the user-friendliness of a system and the quality of the manufacturer's labeling to reduce the risk of handling errors are also important aspects in ensuring reliable and accurate measurement results. In addition, the analytical performance of systems should be less prone to user errors and ambient conditions. Finally, people with diabetes must be aware of the information and instructions in the manufacturer's labeling and must be able to measure and interpret blood glucose results correctly. PMID:23883407

  5. 76 FR 16277 - System Restoration Reliability Standards

    Science.gov (United States)

    2011-03-23

    ...\\ System Restoration Reliability Standards, Notice of Proposed Rulemaking, 75 FR 71625 (Nov. 24, 2010... System, Order No. 693, 72 FR 16416 (Apr. 4, 2007), FERC Stats. & Regs. ] 31,242, at P 297, order on reh'g... required. \\29\\ Regulations Implementing the National Environmental Policy Act, Order No. 486, 52 FR...

  6. Intelligent micro blood typing system using a fuzzy algorithm

    International Nuclear Information System (INIS)

    ABO typing is the first analysis performed on blood when it is tested for transfusion purposes. The automated machines used in hospitals for this purpose are typically very large and the process is complicated. In this paper, we present a new micro blood typing system that is an improved version of our previous system (Kang et al 2004 Trans. ASME, J. Manuf. Sci. Eng. 126 766, Lee et al 2005 Sensors Mater. 17 113). This system, fabricated using microstereolithography, has a passive valve for controlling the flow of blood and antibodies. The intelligent micro blood typing system has two parts: a single-line micro blood typing device and a fuzzy expert system for grading the strength of agglutination. The passive valve in the single-line micro blood typing device makes the blood stop at the entrance of a micro mixer and lets it flow again after the blood encounters antibodies. Blood and antibodies are mixed in the micro mixer and agglutination occurs in the chamber. The fuzzy expert system then determines the degree of agglutination from images of the agglutinated blood. Blood typing experiments using this device were successful, and the fuzzy expert system produces a grading decision comparable to that produced by an expert conducting a manual analysis

  7. Automation and data processing with the immucor Galileo (R) system in a university blood bank

    OpenAIRE

    Wittmann, Georg; Frank, Josef; Schramm, Wolfgang; Spannagl, Michael

    2007-01-01

    Background: The implementation of automated techniques improves the workflow and quality of immuno-hematological results. The workflows of our university blood bank were reviewed during the implementation of an automated immunohematological testing system. Methods: Work impact of blood grouping and subgrouping, cross- matching and antibody search using the Immucor Galileo system was compared to the previous used standard manual and semi- automated methods. Results: The redesign of our workflo...

  8. PROWAY - a standard for distributed control systems

    International Nuclear Information System (INIS)

    The availability of cheap and powerful microcomputer and data communications equipment has led to a major revision of instrumentation and control systems. Intelligent devices can now be used and distributed about the control system in a systematic and economic manner. These sub-units are linked by a communications system to provide a total system capable of meeting the required plant objectives. PROWAY, an international standard process data highway for interconnecting processing units in distributed industrial process control systems, is currently being developed. This paper describes the salient features and current status of the PROWAY effort. (auth)

  9. 75 FR 65052 - Consensus Standards, Standard Practice for Maintenance of Airplane Electrical Wiring Systems

    Science.gov (United States)

    2010-10-21

    ... TRANSPORTATION Federal Aviation Administration Consensus Standards, Standard Practice for Maintenance of Airplane... Practice for Maintenance of Airplane Electrical Wiring Systems (Standard Practice) as an acceptable means... FAA finds the standards to be acceptable methods and procedures for maintenance of electrical...

  10. Scientific and forensic standards for homologous blood transfusion anti-doping analyses.

    Science.gov (United States)

    Giraud, Sylvain; Robinson, Neil; Mangin, Patrice; Saugy, Martial

    2008-07-18

    Since the introduction in 2001 of a urine-based detection method for recombinant erythropoietin (rHuEPO), transfusion-doping practices have regained interest. To address this problem, an efficient antidoping test designed to obtain direct proof of allogeneic blood transfusion was developed and validated. This test, based on flow cytometry analysis of red blood cell (RBCs) phenotypes, was used to determine the absence or the presence of numerous RBCs populations in a blood sample. A such, it may constitute a direct proof of an abnormal blood population resulting from homologous transfusion. Single-blind and single-site studies were carried out to validate this method as a forensic quality standard analysis and to allow objective interpretation of real cases. The analysis of 140 blood samples containing different percentages (0-5%) of a minor RBCs population were carried on by four independent analysts. Robustness, sensitivity, specificity, precision and stability were assessed. ISO-accredited controls samples were used to demonstrate that the method was robust, stable and precise. No false positive results were observed, resulting in a 100% specificity of the method. Most samples containing a 1.5% minor RBCs population were unambiguously detected, yielding a 78.1% sensitivity. These samples mimicked blood collected from an athlete 3 months after a homologous blood transfusion event where 10% of the total RBCs present in the recipient originated in the donor. The observed false negative results could be explained by differences in antigen expression between the donor and the recipient. False negatives were more numerous with smaller minor RBCs populations. The method described here fulfils the ISO-17025 accreditation and validation requirements. The controls and the methodology are solid enough to determine with certainty whether a sample contains one or more RBCs populations. This variable is currently the best indicator for homologous blood transfusion doping.

  11. Business School's Performance Management System Standards Design

    Science.gov (United States)

    Azis, Anton Mulyono; Simatupang, Togar M.; Wibisono, Dermawan; Basri, Mursyid Hasan

    2014-01-01

    This paper aims to compare various Performance Management Systems (PMS) for business school in order to find the strengths of each standard as inputs to design new model of PMS. There are many critical aspects and gaps notified for new model to improve performance and even recognized that self evaluation performance management is not well…

  12. Raising the standard: changes to the Australian Code of Good Manufacturing Practice (cGMP) for human blood and blood components, human tissues and human cellular therapy products.

    Science.gov (United States)

    Wright, Craig; Velickovic, Zlatibor; Brown, Ross; Larsen, Stephen; Macpherson, Janet L; Gibson, John; Rasko, John E J

    2014-04-01

    In Australia, manufacture of blood, tissues and biologicals must comply with the federal laws and meet the requirements of the Therapeutic Goods Administration (TGA) Manufacturing Principles as outlined in the current Code of Good Manufacturing Practice (cGMP). The Therapeutic Goods Order (TGO) No. 88 was announced concurrently with the new cGMP, as a new standard for therapeutic goods. This order constitutes a minimum standard for human blood, tissues and cellular therapeutic goods aimed at minimising the risk of infectious disease transmission. The order sets out specific requirements relating to donor selection, donor testing and minimisation of infectious disease transmission from collection and manufacture of these products. The Therapeutic Goods Manufacturing Principles Determination No. 1 of 2013 references the human blood and blood components, human tissues and human cellular therapy products 2013 (2013 cGMP). The name change for the 2013 cGMP has allowed a broadening of the scope of products to include human cellular therapy products. It is difficult to directly compare versions of the code as deletion of some clauses has not changed the requirements to be met, as they are found elsewhere amongst the various guidelines provided. Many sections that were specific for blood and blood components are now less prescriptive and apply to a wider range of cellular therapies, but the general overall intent remains the same. Use of 'should' throughout the document instead of 'must' allows flexibility for alternative processes, but these systems will still require justification by relevant logical argument and validation data to be acceptable to TGA. The cGMP has seemingly evolved so that specific issues identified at audit over the last decade have now been formalised in the new version. There is a notable risk management approach applied to most areas that refer to process justification and decision making. These requirements commenced on 31 May 2013 and a 12 month

  13. Is intrapartum fetal blood sampling a gold standard diagnostic tool for fetal distress?

    Science.gov (United States)

    Mahendru, Amita A; Lees, Christoph C

    2011-06-01

    Developed in 1960s, cardiotocography is a screening test and fetal blood sampling (FBS) is an adjunctive, diagnostic technique to detect fetal hypoxia. A fetal blood sample pH value of less than 7.20 has a higher specificity than a pathological CTG to predict low Apgar score at 1 min. Though with a pathological CTG and despite a normal FBS pH value the risk of delivering a hypoxic infant is 30-50%, FBS has assumed considerable importance in purportedly reducing unnecessary obstetric intervention. The evidence for this is weak: the use of FBS with CTG has been shown to reduce operative vaginal deliveries though not Caesarean sections due to fetal distress. There is no difference in the umbilical artery pH at delivery with the use of intermittent FBS with CTG compared to CTG alone. FBS is an invasive procedure: obtaining an adequate blood sample is often difficult and the pH results are affected by handling of the sample, aerobic contamination and processing. Validation of intrapartum FBS requires that the pH and other values obtained are compared to a 'gold standard' technique. Although FBS has been compared to other tests such as scalp lactate, pulse oximetry, fetal ECG waveform analysis, and central haemodynamics in labouring rhesus monkeys, none of these can be considered as 'gold standard'. In the light of the existing evidence, the role of intrapartum FBS as a gold standard diagnostic technique is unproven. PMID:21300427

  14. [International standardization of laboratory information systems].

    Science.gov (United States)

    Ishigami, T

    1997-06-01

    The standardization of clinical laboratory information systems is one of the most difficult but important subjects for clinical laboratory community and laboratorians. International Standard Organization (ISO) has the projects in this field (JTC1/SC7) which is the part of approach to the international laboratory standardization (ISO/TC 212). US NCCLS and European CEN/TC 251 are working under ISO/TC 212. In the United States, the National Academy for Clinical Biochemistry (NACB) and the American Association for Clinical Chemistry (AACC) had started recently to organize the international collaboration program on the subject. The Japan Society of Clinical Pathology (JSCP)'s Council of Laboratory Informatics had joined this program in 1995. NACB/AACC's Ad Hoc Committee which was organized in 1996 is now trying to collect the general opinions ("what and how") through their internet home page. The current status of the works on the standardization of clinical laboratory information systems in the U.S., Europe, and Japan is reviewed briefly in this article. HL7 electronic data exchange specification and clinical testing coding systems such as LOINC coding project and JSCP's coding project are also reviewed. PMID:9306712

  15. [Research on Zhejiang blood information network and management system].

    Science.gov (United States)

    Yan, Li-Xing; Xu, Yan; Meng, Zhong-Hua; Kong, Chang-Hong; Wang, Jian-Min; Jin, Zhen-Liang; Wu, Shi-Ding; Chen, Chang-Shui; Luo, Ling-Fei

    2007-02-01

    This research was aimed to develop the first level blood information centralized database and real time communication network at a province area in China. Multiple technology like local area network database separate operation, real time data concentration and distribution mechanism, allopatric backup, and optical fiber virtual private network (VPN) were used. As a result, the blood information centralized database and management system were successfully constructed, which covers all the Zhejiang province, and the real time exchange of blood data was realised. In conclusion, its implementation promote volunteer blood donation and ensure the blood safety in Zhejiang, especially strengthen the quick response to public health emergency. This project lays the first stone of centralized test and allotment among blood banks in Zhejiang, and can serve as a reference of contemporary blood bank information systems in China.

  16. NASA's SDR Standard: Space Telecommunications Radio System

    Science.gov (United States)

    Reinhart, Richard C.; Johnson, Sandra K.

    2007-01-01

    A software defined radio (SDR) architecture used in space-based platforms proposes to standardize certain aspects of radio development such as interface definitions, functional control and execution, and application software and firmware development. NASA has charted a team to develop an open software defined radio hardware and software architecture to support NASA missions and determine the viability of an Agency-wide Standard. A draft concept of the proposed standard has been released and discussed among organizations in the SDR community. Appropriate leveraging of the JTRS SCA, OMG s SWRadio Architecture and other aspects are considered. A standard radio architecture offers potential value by employing common waveform software instantiation, operation, testing and software maintenance. While software defined radios offer greater flexibility, they also poses challenges to the radio development for the space environment in terms of size, mass and power consumption and available technology. An SDR architecture for space must recognize and address the constraints of space flight hardware, and systems along with flight heritage and culture. NASA is actively participating in the development of technology and standards related to software defined radios. As NASA considers a standard radio architecture for space communications, input and coordination from government agencies, the industry, academia, and standards bodies is key to a successful architecture. The unique aspects of space require thorough investigation of relevant terrestrial technologies properly adapted to space. The talk will describe NASA s current effort to investigate SDR applications to space missions and a brief overview of a candidate architecture under consideration for space based platforms.

  17. The Standardization of a Liquid Scintillation System

    International Nuclear Information System (INIS)

    An experimental evaluation is made of methods in current use for the routine standardization of liquid scintillation systems, with special reference to a single photomultiplier arrangement applied to the measurement of tritium in liquid samples. The investigation includes consideration of the problem of scintillator phosphorescence as well as those disadvantages usually associated with the internal standardization procedure, such as the necessity for very accurate dispensing of the small volumes involved. The complications due to phosphorescence, which also accompany the 57Co internal standard method, may be circumvented in the various ways discussed, but special attention has been given to the more satisfactory standardization procedure, the channel-ratio method. This method, which has the advantage of simultaneous measurement both of sample and quenching factor, has been studied in detail using a dioxane-based scintillator and an aqueous tritium standard. Pulse-height spectra were obtained for both quenched and unquenched samples (utilizing both chemical and colour quenching) and the variation of count-rate with pulse height was found to be exponential. The constant of the exponential was characteristic of the degree of quenching and bore a linear relationship to the relative efficiency over a wide range. Since colour quenching is usually accompanied with some chemical quenching, an attempt was made to separate the two effects. They were found to produce similar results down to an efficiency of 15% relative to the unquenched sample. Analysis of the experimental data suggests methods for selecting optimum settings for the two channels over this quenching range according to the requirements of the specific problem. An experimental relationship was also obtained for 57Co internal standardization. Finally the channel ratio, 57Co and internal standard methods were intercompared for various quenching agents. Although the results obtained were not widely different, the

  18. DO STANDARDIZED MANAGEMENT SYSTEMS HINDER INNOVATION PROCESSES?

    Directory of Open Access Journals (Sweden)

    Sandra Milena Castillo

    2008-06-01

    Full Text Available The aim of this research is to respond, from an empirical point of view, to the following question: "Do management systems based on standards hinder innovation processes?". In order to achieve this objective, an empirical work with the participation of 254 companies is presented here. The research was carried out in 2006 within the framework of a wider research project called "Integrated Management Systems (IMS in Spanish Companies". Study results are presented and statistically analyzed Discussion of the research findings and future work are also provided.

  19. Experimental basis of standardized specimen collection: effect of posture on blood picture.

    Science.gov (United States)

    Leppänen, E A; Gräsbeck, R

    1988-03-01

    22 subjectively healthy females were supine, sat in an armchair and stood while specimens of peripheral venous blood were collected after at least 15 min in each position without using a tourniquet. The albumin, haemoglobin, erythrocyte concentration and the haematocrit increased significantly when the subjects assumed a more erect position, probably as a result of increased hydrostatic pressure. The leucocyte count did not rise, and there was a statistically significant drop in the lymphocyte concentration when changing from supine to sitting. However, the leucocyte concentration rose significantly from supine to sitting or standing. When interpreting laboratory data, the difference in the behaviour of different cell species should be kept in mind. However, on the whole this study supports the stipulation contained in international recommendations that the posture of the subject should be standardized before collection of peripheral blood for haematological tests. PMID:3356238

  20. Evaluation of Verigene Blood Culture Test Systems for Rapid Identification of Positive Blood Cultures.

    Science.gov (United States)

    Kim, Jae-Seok; Kang, Go-Eun; Kim, Han-Sung; Kim, Hyun Soo; Song, Wonkeun; Lee, Kyu Man

    2016-01-01

    The performance of molecular tests using the Verigene Gram-Positive and Gram-Negative Blood Culture nucleic acid tests (BC-GP and BC-GN, resp.; Naosphere, Northbrook, IL, USA) was evaluated for the identification of microorganisms detected from blood cultures. Ninety-nine blood cultures containing Gram-positive bacteria and 150 containing Gram-negative bacteria were analyzed using the BC-GP and BC-GN assays, respectively. Blood cultures were performed using the Bactec blood culture system (BD Diagnostic Systems, Franklin Lakes, NJ, USA) and conventional identification and antibiotic-susceptibility tests were performed using a MicroScan system (Siemens, West Sacramento, CA, USA). When a single strain of bacteria was isolated from the blood culture, Verigene assays correctly identified 97.9% (94/96) of Gram-positive bacteria and 93.8% (137/146) of Gram-negative bacteria. Resistance genes mecA and vanA were correctly detected by the BC-GP assay, while the extended-spectrum β-lactamase CTX-M and the carbapenemase OXA resistance gene were detected from 30 cases cultures by the BC-GN assay. The BC-GP and BC-GN assays showed high agreement with conventional identification and susceptibility tests. These tests are useful for rapid identification of microorganisms and the detection of clinically important resistance genes from positive Bactec blood cultures.

  1. China Technical Standardization Development Strategy and National Technical Standardization System Construction Senior Forum Held

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ On the occasion of International Standard Day, China Technical Standardization Development Strategy and National Technical Standardization System Construction Senior Forum was held in Beijing from September 26th to September 28th.

  2. Detection of bacteremia by Difco ESP blood culture system.

    OpenAIRE

    Morello, J A; Leitch, C; Nitz, S.; Dyke, J W; Andruszewski, M; Maier, G.; Landau, W.; Beard, M. A.

    1994-01-01

    In a multicenter study, the Difco ESP blood culture system (Difco Laboratories, Detroit, Mich.) was compared with the BACTEC NR660 system (Becton Dickinson Diagnostic Instrument Systems, Sparks, Md.). The ESP system monitors each blood culture bottle every 12 to 24 min to detect changes in oxygen consumption and gas production by microbes. Equal volumes of blood were inoculated into aerobic ESP-80A and BACTEC 6A, 16A, or PEDS Plus broths and anaerobic ESP-80N and BACTEC 7A or 17A broths and w...

  3. Mathematical Model of Extrinsic Blood Coagulation Cascade Dynamic System

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The blood coagulation system is very important to life. This paper presents a mathematical blood coagulation model for the extrinsic pathway. This model simulates clotting factor VIII, which plays an important role in the coagulation mechanism. The mathematical model is used to study the equilibrium stability, orbit structure, attractors and global stability behavior, with conclusions in accordance with the physiological phenomena. Moreover, the results provide information about blood related illnesses, which can be used for further study of the coagulation mechanism.

  4. Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yonghua; Chen, Zhongping; Saxer, Christopher; Shen, Qimin; Xiang, Shaohua; Boer, Johannes F. de; Nelson, J. Stuart

    2000-09-15

    We used a novel phase-resolved optical Doppler tomographic (ODT) technique with very high flow-velocity sensitivity (10 {mu}m/s) and high spatial resolution (10 {mu}m) to image blood flow in port-wine stain (PWS) birthmarks in human skin. In addition to the regular ODT velocity and structural images, we use the variance of blood flow velocity to map the PWS vessels. Our device combines ODT and therapeutic systems such that PWS blood flow can be monitored in situ before and after laser treatment. To the authors' knowledge this is the first clinical application of ODT to provide a fast semiquantitative evaluation of the efficacy of PWS laser therapy in situ and in real time. (c) 2000 Optical Society of America.

  5. Development of blood extraction system designed by female mosquito's blood sampling mechanism for bio-MEMS

    Science.gov (United States)

    Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Nakamachi, Eiji

    2005-02-01

    A compact and wearable wristwatch type Bio-MEMS such as a health monitoring system (HMS) to detect blood sugar level for diabetic patient, was newly developed. The HMS consists of (1) a indentation unit with a microneedle to generate the skin penetration force using a shape memory alloy(SMA) actuator, (2) a pumping unit using a bimorph PZT piezoelectric actuator to extract the blood and (3) a gold (Au) electrode as a biosensor immobilized GOx and attached to the gate electrode of MOSFET to detect the amount of Glucose in extracted blood. GOx was immobilized on a self assembled spacer combined with an Au electrode by the cross-link method using BSA as an additional bonding material. The device can extract blood in a few microliter through a painless microneedle with the negative pressure by deflection of the bimorph PZT piezoelectric actuator produced in the blood chamber, by the similar way the female mosquito extracts human blood with muscle motion to flex or relax. The performances of the liquid sampling ability of the pumping unit through a microneedle (3.8mm length, 100μm internal diameter) using the bimorph PZT piezoelectric microactuator were measured. The blood extraction micro device could extract human blood at the speed of 2μl/min, and it is enough volume to measure a glucose level, compared to the amount of commercial based glucose level monitor. The electrode embedded in the blood extraction device chamber could detect electrons generated by the hydrolysis of hydrogen peroxide produced by the reaction between GOx and glucose in a few microliter extracted blood, using the constant electric current measurement system of the MOSFET type hybrid biosensor. The output voltage for the glucose diluted in the chamber was increased lineally with increase of the glucose concentration.

  6. Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis

    Directory of Open Access Journals (Sweden)

    Walsh Michael

    2010-06-01

    Full Text Available Abstract Background Left ventricular (LV hypertrophy is common among patients on hemodialysis. While a relationship between blood pressure (BP and LV hypertrophy has been established, it is unclear which BP measurement method is the strongest correlate of LV hypertrophy. We sought to determine agreement between various blood pressure measurement methods, as well as identify which method was the strongest correlate of LV hypertrophy among patients on hemodialysis. Methods This was a post-hoc analysis of data from a randomized controlled trial. We evaluated the agreement between seven BP measurement methods: standardized measurement at baseline; single pre- and post-dialysis, as well as mean intra-dialytic measurement at baseline; and cumulative pre-, intra- and post-dialysis readings (an average of 12 monthly readings based on a single day per month. Agreement was assessed using Lin's concordance correlation coefficient (CCC and the Bland Altman method. Association between BP measurement method and LV hypertrophy on baseline cardiac MRI was determined using receiver operating characteristic curves and area under the curve (AUC. Results Agreement between BP measurement methods in the 39 patients on hemodialysis varied considerably, from a CCC of 0.35 to 0.94, with overlapping 95% confidence intervals. Pre-dialysis measurements were the weakest predictors of LV hypertrophy while standardized, post- and inter-dialytic measurements had similar and strong (AUC 0.79 to 0.80 predictive power for LV hypertrophy. Conclusions A single standardized BP has strong predictive power for LV hypertrophy and performs just as well as more resource intensive cumulative measurements, whereas pre-dialysis blood pressure measurements have the weakest predictive power for LV hypertrophy. Current guidelines, which recommend using pre-dialysis measurements, should be revisited to confirm these results.

  7. SBR-Blood: systems biology repository for hematopoietic cells.

    Science.gov (United States)

    Lichtenberg, Jens; Heuston, Elisabeth F; Mishra, Tejaswini; Keller, Cheryl A; Hardison, Ross C; Bodine, David M

    2016-01-01

    Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows user-initiated analyses for cell type correlations or gene-specific behavior during differentiation using publicly available datasets for array- and sequencing-based platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles. PMID:26590403

  8. Non-ABO blood group systems phenotyping in non-human primates for blood banking laboratory and xenotransplantation.

    Science.gov (United States)

    Ramis, G; Martínez-Alarcon, L; Quereda, J J; Mrowiec, A; Funes, C; Ríos, A; Ramírez, P; Muñoz, A; Majado, M J

    2013-04-01

    Some biomedical research procedures, such as organ xenotransplantation, usually require intensive hemotherapy. Knowledge of the whole phenotype of blood donor and graft could be useful in the field of xenotransplantation. Human and simian-type categories of blood groups have been established and they can be tested by standard methods used for human blood grouping. The aim of this work was to study the incidence of non-ABO blood group systems in different species of non-human primates, which are employed in biomedical research. The phenotype of Rh, Lewis, Kidd, Kell, MNSs, Lutheran, P and Duffy antigens was investigated in olive baboon (n = 48), chacma baboon (n = 9), Guinea baboon (n = 14), Rhesus macaque (n = 38) and squirrel monkey (n = 30) by using commercial microtyping cards. Kell, Lutheran, Kidd and Duffy antigens have been detected in all species, Rh in squirrel monkey, MNSs in rhesus macaque and squirrel monkey, and Lewis in baboon and rhesus macaque. There were differences in frequency and haemagglutination scores between species regardless of their gender and age. The main differences were found in squirrel monkey when compared with baboons and macaques. This typing system provides a tool to assess the presence of antigens in animals used for experimental procedures, such as xenotransplantation and xenotransfusion. PMID:23563364

  9. Results of Pancreatic Blood Shunting into the Systemic Blood Flow in Insulin-Dependent Diabetics

    OpenAIRE

    Galperin, E. I.; Diuzheva, T. G.; Petrovsky, P. F.; A. Yu. Chevokin; Dokuchayev, K. V.; Rabinovich, S. E.; Gitel, E. P.; Kuzovlev, N. F.; Platonov, L. V.

    1996-01-01

    A new surgical method of treating patients with unstable insulin-dependent diabetes (IDD) has been developed-that of surgically shunting pancreatic blood into the systemic blood flow with the purpose of creating a more optimal interaction of subcutaneously administered insulin and pancreas-secreted glucagon. The long term results of the operation depend on the patency of a splenorenal anastomosis. This has been studied by following up 137 patients over periods from half a year to three years....

  10. The Standard System and Quality and Safety Standards for Banana in China

    OpenAIRE

    ZOU, Dongmei; PAN, Yongbo; Xu, Zhi; LUO, Jinhui

    2015-01-01

    Banana is an important tropical fruit and China is the world's third largest banana producer. The standardization level of banana industry not only affects the yield and quality of banana, but also plays an important role in promoting the production standardization and industrialization of other tropical crops. Through the analysis of revision, publicity and implementation of banana standard system in China as well as the study on its standard system and quality and safety standards, it is fo...

  11. System Accuracy Evaluation of the GlucoRx Nexus Voice TD-4280 Blood Glucose Monitoring System

    Directory of Open Access Journals (Sweden)

    Muhammad Khan

    2014-01-01

    Full Text Available Use of blood glucose (BG meters in the self-monitoring of blood glucose (SMBG significantly lowers the risk of diabetic complications. With several BG meters now commercially available, the International Organization for Standardization (ISO ensures that each BG meter conforms to a set degree of accuracy. Although adherence to ISO guidelines is a prerequisite for commercialization in Europe, several BG meters claim to meet the ISO guidelines yet fail to do so on internal validation. We conducted a study to determine whether the accuracy of the GlucoRx Nexus TD-4280 meter, utilized by our department for its cost-effectiveness, complied with ISO guidelines. 105 patients requiring laboratory blood glucose analysis were randomly selected and reference measurements were determined by the UniCel DxC 800 clinical system. Overall the BG meter failed to adhere to the ≥95% accuracy criterion required by both the 15197:2003 (overall accuracy 92.4% and 15197:2013 protocol (overall accuracy 86.7%. Inaccurate meters have an inherent risk of over- and/or underestimating the true BG concentration, thereby risking patients to incorrect therapeutic interventions. Our study demonstrates the importance of internally validating the accuracy of BG meters to ensure that its accuracy is accepted by standardized guidelines.

  12. Integration of Standardized Management Systems: A Dilemma?

    Directory of Open Access Journals (Sweden)

    Manuel Ferreira Rebelo

    2015-06-01

    Full Text Available The growing proliferation of management systems standards (MSSs, and their individualized implementation, is a real problem faced by organizations. On the other hand, MSSs are aimed at improving efficiency and effectiveness of organizational responses in order to satisfy the requirements, needs and expectations of the stakeholders. Each organization has its own identity and this is an issue that cannot be neglected; hence, two possible approaches can be attended. First, continue with the implementation of individualized management systems (MSs; or, integrate the several MSSs versus related MSs into an integrated management system (IMS. Therefore, in this context, organizations are faced with a dilemma, as a result of the increasing proliferation and diversity of MSSs. This paper takes into account the knowledge gained through a case study conducted in the context of a Portuguese company and unveils some of the advantages and disadvantages of integration. A methodology is also proposed and presented to support organizations in developing and structuring the integration process of their individualized MSs, and consequently minimize problems that are generators of inefficiencies, value destruction and loss of competitiveness. The obtained results provide relevant information that can support Top Management decision in solving that dilemma and consequently promote a successful integration, including a better control of business risks associated to MSSs requirements and enhancing sustainable performance, considering the context in which organizations operate.

  13. 42 CFR 493.1249 - Standard: Preanalytic systems quality assessment.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Preanalytic systems quality assessment... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing Preanalytic Systems § 493.1249 Standard: Preanalytic systems quality assessment. (a)...

  14. 42 CFR 493.1299 - Standard: Postanalytic systems quality assessment.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Postanalytic systems quality assessment... AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing Postanalytic Systems § 493.1299 Standard: Postanalytic systems quality assessment. (a)...

  15. 42 CFR 493.1289 - Standard: Analytic systems quality assessment.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Analytic systems quality assessment. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing Analytic Systems § 493.1289 Standard: Analytic systems quality assessment. (a)...

  16. Standard sample supply system; Hyojun shiryo kyokyu system

    Energy Technology Data Exchange (ETDEWEB)

    Osaka, S. [Center for Coal Utilization Japan, Tokyo (Japan)

    1997-03-20

    More than 20 universities and research institutes participate in the study of developing basic technology of coal utilization, and the `Standard sample supply system` prepares, keeps and supplys standard samples so that common samples can be used in the study. Coal samples of 50 to 100 will be prepared for 5 years. A coal sample is about 160 kg. The samples are collected from coal yards of big consumers such as power stations, etc. and coal suppliers. How to smash and keep coal are also described. Main facilities and machinery and their specification are given. Each standard sample is analyzed by means of the coal and ash analysis method of JIS and the data are distributed. The items of the analysis are shown in table. A database system will be prepared by the end of 1996. 2 figs., 2 tabs.

  17. Process Control System Cyber Security Standards - An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans

    2006-05-01

    The use of cyber security standards can greatly assist in the protection of process control systems by providing guidelines and requirements for the implementation of computer-controlled systems. These standards are most effective when the engineers and operators, using the standards, understand what each standard addresses. This paper provides an overview of several standards that deal with the cyber security of process measurements and control systems.

  18. Survey of standards applicable to a database management system

    Science.gov (United States)

    Urena, J. L.

    1981-01-01

    Industry, government, and NASA standards, and the status of standardization activities of standards setting organizations applicable to the design, implementation and operation of a data base management system for space related applications are identified. The applicability of the standards to a general purpose, multimission data base management system is addressed.

  19. 78 FR 18353 - Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility...

    Science.gov (United States)

    2013-03-26

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Blood Establishment Computer System... ``Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility'' dated April... document entitled ``Guidance for Industry: Blood Establishment Computer System Validation in the...

  20. Effects of carboxymethyl chitosan on the blood system of rats

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Dawei [College of Marine Life Sciences, Ocean University of China, Qingdao 266003 (China); Han, Baoqin, E-mail: baoqinh@ouc.edu.cn [College of Marine Life Sciences, Ocean University of China, Qingdao 266003 (China); Dong, Wen; Yang, Zhao; Lv, You; Liu, Wanshun [College of Marine Life Sciences, Ocean University of China, Qingdao 266003 (China)

    2011-04-29

    Highlights: {yields} We report, for the first time, the safety of carboxymethyl chitosan in blood system. {yields} CM-Chitosan has no significant effects on coagulation function of rats. {yields} CM-Chitosan has no significant effects on anticoagulation performance of rats. {yields} CM-Chitosan has no significant effects on fibrinolytic function of rats. {yields} CM-Chitosan has no significant effects on hemorheology of rats. -- Abstract: Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.

  1. Effects of carboxymethyl chitosan on the blood system of rats

    International Nuclear Information System (INIS)

    Highlights: → We report, for the first time, the safety of carboxymethyl chitosan in blood system. → CM-Chitosan has no significant effects on coagulation function of rats. → CM-Chitosan has no significant effects on anticoagulation performance of rats. → CM-Chitosan has no significant effects on fibrinolytic function of rats. → CM-Chitosan has no significant effects on hemorheology of rats. -- Abstract: Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, was extensively studied in the biomedical materials field for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CM-chitosan in the blood system are lacking. In this study CM-chitosan was implanted into the abdominal cavity of rats to determine blood indexes at different times and to evaluate the effects of CM-chitosan on the blood system of rats. Coagulation function was reflected by thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4) indexes; anti-coagulation performance was assessed by the index of antithrombinIII (ATIII); fibrinolytic function was reflected by plasminogen (PLG) and fibrin degradation product (FDP) indexes; and blood viscosity (BV) and plasma viscosity (PV) indexes reflected hemorheology. Results showed that CM-chitosan has no significant effects on the blood system of rats, and provides experimental basis for CM-chitosan to be applied in the field of biomedical materials.

  2. BIOCHEMICAL STANDARDIZATION OF TORTEZIN, A NOVEL IMMUNOSTIMULATOR FROM THE TORTOISE BLOOD CELLS

    Directory of Open Access Journals (Sweden)

    NIGORA TAGAYALIEVA

    2011-11-01

    Full Text Available Objective: The biochemical characterization of the substances presented in the new haemo and immuno stimulating preparation Tortezin from the blood cells of the Central Asian tortoise. Materials and Methods: Tortezin substances manufactured in 20062010 were examined by electrophoresis, spectroscopy and RPHPLC. Results: In UV spectra of Tortezin aqueous solution the pronounced maximum was at 218±1.2 nm and mild spike at 280±3.2 nm; in fluorescence emission spectra upon excitation with wavelength at 280 nm peak emission maximum was 460 ± 38 nm and at 295 nm was 455±21 nm. The RPHPLC profile and SDS 10% PAGE showed the presence of repetitive typical peaks in different samples. Conclusion: The different methods are to be recommended for standardization of Tortezin

  3. Standardized equipment system for mining mineral resources

    Energy Technology Data Exchange (ETDEWEB)

    Reinel, H.

    1986-08-01

    Technical specifications are presented of surface mining equipment developed by TAKRAF (GDR) for small to medium sized mines (coal, gravel, kaolin, bauxite, sulfur, limestone etc. with production capacity of less than 1 Mm/sup 3//y). The continuous bulk flow equipment consists of small bucket wheel excavators, small bucket chain excavators, mobile transfer conveyors and shiftable belt conveyors. Bucket wheel excavators (series SRs 65 to SRa 320) have a production capacity between 200 and 2300 m/sup 3//h and weigh between 45 and 290 t. The SRs 320 is suitable for mining medium thick coal seams. The ERs 50 to ERs 250 bucket chain excavator series has a production capacity between 225 and 1100 m/sup 3//h and weight between 54 and 275 t. Both bucket wheel and bucket chain excavator series have the same standard undercarriage, loading boom, slewing system and driver's cabin. Bulk conveying capacities of BRs 650 to BRs 1200 mobile transfer conveyors correspond to those of excavators. Shiftable belt conveyors (0.8 m to 1.4 m belt widths, 3100 m maximum conveyor length) complete the equipment system.

  4. The Standard System and Quality and Safety Standards for Banana in China

    Institute of Scientific and Technical Information of China (English)

    Dongmei; ZOU; Yongbo; Pan; Zhi; XU; Jinhui; LUO

    2015-01-01

    Banana is an important tropical fruit and China is the world’s third largest banana producer. The standardization level of banana industry not only affects the yield and quality of banana,but also plays an important role in promoting the production standardization and industrialization of other tropical crops. Through the analysis of revision,publicity and implementation of banana standard system in China as well as the study on its standard system and quality and safety standards,it is found that there are some problems such as irrational banana standard structure,short period of validity of standard,low level of quality and safety standards,and loose link between standards and production. At the same time,some recommendations are put forward in order to guide the standardized production and trade,research and management of banana and promote sustained,healthy and stable development of the banana industry in China.

  5. 77 FR 33489 - Draft Offender Tracking System Standard

    Science.gov (United States)

    2012-06-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Draft Offender Tracking System Standard AGENCY: National Institute of Justice. ACTION: Notice of Draft Offender Tracking System Standard, Selection and Application Guide,...

  6. Computer systems and software description for Standard-E+ Hydrogen Monitoring System (SHMS-E+)

    International Nuclear Information System (INIS)

    The primary function of the Standard-E+ Hydrogen Monitoring System (SHMS-E+) is to determine tank vapor space gas composition and gas release rate, and to detect gas release events. Characterization of the gas composition is needed for safety analyses. The lower flammability limit, as well as the peak burn temperature and pressure, are dependent upon the gas composition. If there is little or no knowledge about the gas composition, safety analyses utilize compositions that yield the worst case in a deflagration or detonation. Knowledge of the true composition could lead to reductions in the assumptions and therefore there may be a potential for a reduction in controls and work restrictions. Also, knowledge of the actual composition will be required information for the analysis that is needed to remove tanks from the Watch List. Similarly, the rate of generation and release of gases is required information for performing safety analyses, developing controls, designing equipment, and closing safety issues. This report outlines the computer system design layout description for the Standard-E+ Hydrogen Monitoring System

  7. Computer systems and software description for Standard-E+ Hydrogen Monitoring System (SHMS-E+)

    Energy Technology Data Exchange (ETDEWEB)

    Tate, D.D.

    1997-05-01

    The primary function of the Standard-E+ Hydrogen Monitoring System (SHMS-E+) is to determine tank vapor space gas composition and gas release rate, and to detect gas release events. Characterization of the gas composition is needed for safety analyses. The lower flammability limit, as well as the peak burn temperature and pressure, are dependent upon the gas composition. If there is little or no knowledge about the gas composition, safety analyses utilize compositions that yield the worst case in a deflagration or detonation. Knowledge of the true composition could lead to reductions in the assumptions and therefore there may be a potential for a reduction in controls and work restrictions. Also, knowledge of the actual composition will be required information for the analysis that is needed to remove tanks from the Watch List. Similarly, the rate of generation and release of gases is required information for performing safety analyses, developing controls, designing equipment, and closing safety issues. This report outlines the computer system design layout description for the Standard-E+ Hydrogen Monitoring System.

  8. 7 CFR 3016.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Standards for financial management systems. 3016.20... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards:...

  9. 43 CFR 12.60 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Standards for financial management systems... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards:...

  10. 7 CFR 277.6 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Standards for financial management systems. 277.6... ADMINISTRATIVE COSTS OF STATE AGENCIES § 277.6 Standards for financial management systems. (a) General. This section prescribes standards for financial management systems in administering program funds by the...

  11. 29 CFR 97.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Standards for financial management systems. 97.20 Section 97... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards:...

  12. Application of Blood Appointment System in Hospital%血液预约系统在医院的应用

    Institute of Scientific and Technical Information of China (English)

    王飞; 李刚荣; 蒋天伦

    2011-01-01

    目的:通过血液预约,缓解血液供需关系.方法:应用现代信息技术手段,通过血液信息管理系统与医院信息管理系统的无缝连接及互联网优势,制订血液采集计划,招募献血者,控制血液库存.结果:规范了临床用血,缩短了血液在血库的流动周期,降低了血液管理成本.结论:血液预约是缓解血液供需关系的有效途径.%Objective: according to blood appointment, to relieve the supply and demand of blood.Method: apply the modern information technology, through seamless connection of the blood information system and hospital information system, the advantage of internet, to develop the program of blood connection, and recruit blood donors to control blood inventory.Result: standard the clinic blood, shorten the flow cycle of blood in blood bank, reduce the blood management costs.Conclusion: blood appointment is effective way to relieve the supply and demand of blood.

  13. Study on the entire system of maintenance codes and standards

    International Nuclear Information System (INIS)

    In this study, a structure of code and standard system for plant maintenance is discussed along a process of maintenance activities. As a result of consideration, it was concluded as follows. (1) It is assumed that the entire system of maintenance codes and standards consists of four standards, that is, standards regarding maintenance planning, maintenance implementation, evaluation of inspection/maintenance results and corrective measures. (2) The maintenance guidelines and fitness-for-service codes discussed already so far occupies a position in the entire system of maintenance codes and standards. (3) Maintenance codes and standards, which have higher priority, should be developed. (author)

  14. A comprehensive evaluation of strip performance in multiple blood glucose monitoring systems.

    Science.gov (United States)

    Katz, Laurence B; Macleod, Kirsty; Grady, Mike; Cameron, Hilary; Pfützner, Andreas; Setford, Steven

    2015-05-01

    Accurate self-monitoring of blood glucose is a key component of effective self-management of glycemic control. Accurate self-monitoring of blood glucose results are required for optimal insulin dosing and detection of hypoglycemia. However, blood glucose monitoring systems may be susceptible to error from test strip, user, environmental and pharmacological factors. This report evaluated 5 blood glucose monitoring systems that each use Verio glucose test strips for precision, effect of hematocrit and interferences in laboratory testing, and lay user and system accuracy in clinical testing according to the guidelines in ISO15197:2013(E). Performance of OneTouch(®) VerioVue™ met or exceeded standards described in ISO15197:2013 for precision, hematocrit performance and interference testing in a laboratory setting. Performance of OneTouch(®) Verio IQ™, OneTouch(®) Verio Pro™, OneTouch(®) Verio™, OneTouch(®) VerioVue™ and Omni Pod each met or exceeded accuracy standards for user performance and system accuracy in a clinical setting set forth in ISO15197:2013(E). PMID:25702769

  15. A Comparative Study of Blood Glucose Measurements Using Glucometer Readings and the Standard Method in the Diagnosis of Neonatal Hypoglycemia

    Directory of Open Access Journals (Sweden)

    Mohammad Torkaman

    2016-03-01

    Full Text Available Background: Hypoglycemia is one of the most common neonatal disorders, associated with severe complications. There has been a great deal of controversy regarding the definition and screening of hypoglycemia. Therefore, in this study, we aimed to determine a cut-off value for blood glucose level in glucometer readings. Methods: This cross-sectional study was conducted on 238 newborns at risk of hypoglycemia, admitted to Baqiyatallah Hospital of Tehran, Iran in 2012; the subjects were selected via simple sampling. After obtaining informed consents from the newborns’ parents, 1 cc blood samples were sent to the laboratory for measuring the blood glucose level. Moreover, venous blood samples, as well as heel-stick blood samples, were obtained for glucometer measurements. Blood glucose measurements were used to determine the cut-off value by the receiver operating characteristic (ROC curve and make comparisons with the diagnostic criteria for hypoglycemia in the literature. Results: A total of 238 infants with the mean weight of 2869±821.9 g were enrolled in this study. The mean (±SD blood glucose levels were 65.1±22.9, 82.9±24.7, and 84.4±24.8 mg/dl, based on the standard laboratory method, glucometer reading of venous blood samples, and glucometer reading of heel-stick capillary blood samples, respectively. The optimal cut-off point for hypoglycemia was determined as 65 mg/dl, using glucometer-based assessment of heel-stick blood samples. Conclusion: The significant difference in blood glucose levels measured by the laboratory method and outpatient glucometer readings highlights the importance of a cut-off value for rapid assessment and control of blood glucose and timely detection of hypoglycemia. In fact, the cut-off value introduced in the present study could facilitate such measurements.

  16. State Standards and State Assessment Systems: A Guide to Alignment. Series on Standards and Assessments.

    Science.gov (United States)

    La Marca, Paul M.; Redfield, Doris; Winter, Phoebe C.

    Alignment of content standards, performance standards, and assessments is crucial. This guide contains information to assist states and districts in aligning their assessment systems to their content and performance standards. It includes a review of current literature, both published and fugitive. The research is woven together with a few basic…

  17. Building Standards based Science Information Systems: A Survey of ISO and other standards

    Science.gov (United States)

    King, Todd; Walker, Raymond

    Science Information systems began with individual researchers maintaining personal collec-tions of data and managing them by using ad hoc, specialized approaches. Today information systems are an enterprise consisting of federated systems that manage and distribute both historical and contemporary data from distributed sources. Information systems have many components. Among these are metadata models, metadata registries, controlled vocabularies and ontologies which are used to describe entities and resources. Other components include services to exchange information and data; tools to populate the system and tools to utilize available resources. When constructing information systems today a variety of standards can be useful. The benefit of adopting standards is clear; it can shorten the design cycle, enhance software reuse and enable interoperability. We look at standards from the International Stan-dards Organization (ISO), International Telecommunication Union (ITU), Organization for the Advancement of Structured Information Standards (OASIS), Internet Engineering Task Force (IETF), American National Standards Institute (ANSI) which have influenced the develop-ment of information systems in the Heliophysics and Planetary sciences. No standard can solve the needs of every community. Individual disciplines often must fill the gap between general purpose standards and the unique needs of the discipline. To this end individual science dis-ciplines are developing standards, Examples include the International Virtual Observatory Al-liance (IVOA), Planetary Data System (PDS)/ International Planetary Data Alliance (IPDA), Dublin-Core Science, and the Space Physics Archive Search and Extract (SPASE) consortium. This broad survey of ISO and other standards provides some guidance for the development information systems. The development of the SPASE data model is reviewed and provides some insights into the value of applying appropriate standards and is used to illustrate

  18. Standard-D hydrogen monitoring system, system design description

    International Nuclear Information System (INIS)

    During most of the year, it is assumed that the vapor space in the 177 radioactive waste tanks on the Hanford Project site contain a uniform mixture of gases. Several of these waste tanks (currently twenty-five, 6 Double Shell Tanks and 19 Single Shell Tanks) were identified as having the potential for the buildup of gasses to a flammable level. An active ventilation system in the Double Shell Tanks and a passive ventilation system in the Single Shell Tanks provides a method of expelling gasses from the tanks. A gas release from a tank causes a temporary rise in the tank pressure, and a potential for increased concentration of hydrogen gas in the vapor space. The gas is released via the ventilation systems until a uniform gas mixture in the vapor space is once again achieved. The Standard Hydrogen Monitoring System (SHMS) is designed to monitor and quantify the percent hydrogen concentration during these potential gas releases. This document describes the design of the Standard-D Hydrogen Monitoring System, (SHMS-D) and its components as it differs from the original SHMS

  19. 40 CFR 61.346 - Standards: Individual drain systems.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Standards: Individual drain systems. 61... Waste Operations § 61.346 Standards: Individual drain systems. (a) Except as provided in paragraph (b) of this section, the owner or operator shall meet the following standards for each individual...

  20. System 80+trademark Standard Design: CESSAR design certification

    International Nuclear Information System (INIS)

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80+trademark Standard Design. This volume 10 discusses the Steam and Power Conversion System and Radioactive Waste Management

  1. System for Sewing Machine Industry Standard Innovation——Constructive Research for a Technical Standards System for Sewing Machines

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Constructive research of a market-oriented industry's system of technical standardization by redefining those technical standards is the basis of innovation. Through considering and implementing innovation of the industry's standards,rapid development and standardization of the industry can be achieved.

  2. 10 CFR 600.311 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Standards for financial management systems. 600.311... Requirements § 600.311 Standards for financial management systems. (a) Recipients are encouraged to use existing financial management systems to the extent that the systems comply with Generally...

  3. System 80+trademark standard design: CESSAR design certification

    International Nuclear Information System (INIS)

    This report has been prepared in support of the industry effort to standardize nuclear plant designs. The documents in this series describe the Combustion Engineering, Inc. System 80+TM Standard Design

  4. Standardization of information systems development processes and banking industry adaptations

    OpenAIRE

    Tuna Ozcer; Zuhal Tanrikulu

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall l...

  5. How the python heart separates pulmonary and systemic blood pressures and blood flows.

    Science.gov (United States)

    Jensen, Bjarke; Nielsen, Jan M; Axelsson, Michael; Pedersen, Michael; Löfman, Carl; Wang, Tobias

    2010-05-01

    The multiple convergent evolution of high systemic blood pressure among terrestrial vertebrates has always been accompanied by lowered pulmonary pressure. In mammals, birds and crocodilians, this cardiac separation of pressures relies on the complete division of the right and left ventricles by a complete ventricular septum. However, the anatomy of the ventricle of most reptiles does not allow for complete anatomical division, but the hearts of pythons and varanid lizards can produce high systemic blood pressure while keeping the pulmonary blood pressure low. It is also known that these two groups of reptiles are characterised by low magnitudes of cardiac shunts. Little, however, is known about the mechanisms that allow for this pressure separation. Here we provide a description of cardiac structures and intracardiac events that have been revealed by ultrasonic measurements and angioscopy. Echocardiography revealed that the atrioventricular valves descend deep into the ventricle during ventricular filling and thereby greatly reduce the communication between the systemic (cavum arteriosum) and pulmonary (cavum pulmonale) ventricular chambers during diastole. Angioscopy and echocardiography showed how the two incomplete septa, the muscular ridge and the bulbuslamelle - ventricular structures common to all squamates - contract against each other in systole and provide functional division of the anatomically subdivided ventricle. Washout shunts are inevitable in the subdivided snake ventricle, but we show that the site of shunting, the cavum venosum, is very small throughout the cardiac cycle. It is concluded that the python ventricle is incapable of the pronounced and variable shunts of other snakes, because of its architecture and valvular mechanics.

  6. Practice of standardized management of the portable blood glucose meter%便携式血糖仪的规范化管理实践

    Institute of Scientific and Technical Information of China (English)

    常玉锋

    2014-01-01

    Objective: To apply the norms of the portable blood glucose meter in clinic and improve the quality and level of blood glucose detection. Methods:The management organization of the portable blood glucose meter was established. The organization understudied the working principles and the advantages and disadvantages of blood glucose meter. The model of the portable blood glucose meter was unified in a medical unit. The performance of the portable blood glucose meter and the biochemical analyzer was compared. The organization established standard operating procedures, strengthen personnel training. The clinical staff takes quality control regular. Results:The qualified rate of the use, the maintenance and the results detection was increased. Conclusion:The standardized management system guarantees the detection result of the portable blood glucose meter.%目的:规范便携式血糖仪在临床中的应用,提高血糖检测质量和检测水平。方法:成立统一的便携式血糖仪管理小组,同一医疗单元的便携式血糖仪统一型号,并进行全面的生化比对分析,使用中制定统一的标准操作规程,加强使用人员的培训,定期进行室内及室间质控。结果:医院人员的便携式血糖仪知识掌握率、操作使用合格率及结果检查合格率均大幅上升。结论:规范的管理体系为便携式血糖仪检测结果的可靠性提供了保障。

  7. Implications of the Kidd blood group system in renal transplantation.

    Science.gov (United States)

    Rourk, A; Squires, J E

    2012-01-01

    The association of the Kidd blood group system with hemolytic transfusion reactions and hemolytic disease of the newborn is well known. The Kidd antigens, which are localized to the HUT/UT-B urea transport protein, are found on red blood cells and the endothelial cells of the blood vessels of the medulla of the kidney. Recently it has been suggested that these antigens might play a role as minor histocompatibility antigens in renal transplantation. In the current case, the appearance of an anti-Jk(b) 10 years after renal transplantation associated with early renal allograft rejection further supports the potential importance of these antigens in renal transplantation and allograft rejection. PMID:23286555

  8. 14 CFR 1260.121 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Standards for financial management systems... Requirements § 1260.121 Standards for financial management systems. (a) Recipients shall relate financial data...) Recipients' financial management systems shall provide for the following. (1) Accurate, current and...

  9. 45 CFR 1183.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Standards for financial management systems. 1183... Financial Administration § 1183.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  10. 10 CFR 600.220 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Standards for financial management systems. 600.220... Post-Award Requirements § 600.220 Standards for financial management systems. (a) A State must expend... prohibitions of applicable statutes. (b) The financial management systems of other grantees and...

  11. 7 CFR 3019.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Standards for financial management systems. 3019.21... Requirements Financial and Program Management § 3019.21 Standards for financial management systems. (a) Federal... cost information whenever practical. (b) Recipients' financial management systems shall provide for...

  12. 2 CFR 215.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Standards for financial management systems... Financial and Program Management § 215.21 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the...

  13. 43 CFR 12.921 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Standards for financial management systems... Organizations Post-Award Requirements § 12.921 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the...

  14. 22 CFR 135.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards for financial management systems. 135... Financial Administration § 135.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  15. 44 CFR 13.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... Standards for financial management systems. (a) A State must expand and account for grant funds in... financial management systems of other grantees and subgrantees must meet the following standards: (1... review the adequacy of the financial management system of any applicant for financial assistance as...

  16. 14 CFR 1273.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Standards for financial management systems... Requirements Financial Administration § 1273.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and...

  17. 32 CFR 32.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Standards for financial management systems. 32... Program Management § 32.21 Standards for financial management systems. (a) DoD Components shall require... unit cost information. (b) Recipients' financial management systems shall provide for the following....

  18. 34 CFR 80.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Standards for financial management systems. 80.20... Financial Administration § 80.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  19. 45 CFR 602.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Standards for financial management systems. 602.20... GOVERNMENTS Post-Award Requirements § 602.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and...

  20. 49 CFR 18.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Standards for financial management systems. 18.20... Administration § 18.20 Standards for financial management systems. (a) A State must expand and account for grant... statutes. (b) The financial management systems of other grantees and subgrantees must meet the...

  1. 20 CFR 437.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Standards for financial management systems... Financial Administration § 437.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  2. 45 CFR 1157.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Standards for financial management systems. 1157... Administration § 1157.20 Standards for financial management systems. (a) A State must expand and account for... statutes. (b) The financial management systems of other grantees and subgrantees must meet the...

  3. 29 CFR 95.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Standards for financial management systems. 95.21 Section 95... Requirements Financial and Program Management § 95.21 Standards for financial management systems. (a... practical. (b) Recipients' financial management systems shall provide for the following: (1)...

  4. 45 CFR 1174.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Standards for financial management systems. 1174... Financial Administration § 1174.20 Standards for financial management systems. (a) A State must expand and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  5. 49 CFR 19.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Standards for financial management systems. 19.21... ORGANIZATIONS Post-Award Requirements § 19.21 Standards for financial management systems. (a) Federal awarding... information whenever practical. (b) Recipients' financial management systems shall provide for the...

  6. 29 CFR 1470.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Standards for financial management systems. 1470.20 Section... Post-Award Requirements Financial Administration § 1470.20 Standards for financial management systems... the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

  7. 21 CFR 1403.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Standards for financial management systems. 1403... Financial Administration § 1403.20 Standards for financial management systems. (a) A State must expend and... of applicable statutes. (b) The financial management systems of other grantees and subgrantees...

  8. 40 CFR 60.692-2 - Standards: Individual drain systems.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standards: Individual drain systems. 60... Emissions From Petroleum Refinery Wastewater Systems § 60.692-2 Standards: Individual drain systems. (a)(1) Each drain shall be equipped with water seal controls. (2) Each drain in active service shall...

  9. The Application of Standardization System in Corporate Management and Administration

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper briefly discusses three important components of corporate standardization system and their functions and how such a system can be used in corporate management and administration. It also offers certain solutions and suggestions to some of the existing problems in the process of implementing corporate standardization system.

  10. Carotid arterial blood pressure waveform monitoring using a portable ultrasound system.

    Science.gov (United States)

    Joohyun Seo; Pietrangelo, Sabino J; Hae-Seung Lee; Sodini, Charles G

    2015-08-01

    This work presents a non-invasive arterial blood pressure (ABP) waveform monitoring technique using ultrasound. A portable ultrasound system to excite ultrasound transducers and acquire data is designed with off-the-shelf components. The insonation angles are identified using a vector Doppler technique based on the cosine dependency of the Doppler signals. The pulse pressure of an estimated waveform at the left common carotid artery is compared to the standard sphygmomanometer measurement in a clinical test. The estimated carotid ABP waveform shows excellent agreement to the finger ABP waveform with expected discrepancy of the systolic peak shape due to different measurement sites. The proposed method also tracks slow blood pressure fluctuations. This validation on human subjects shows potential for a noninvasive blood pressure waveform monitoring device at central arterial sites. PMID:26737584

  11. Standard-B Hydrogen Monitoring System, system design description

    International Nuclear Information System (INIS)

    During most of the year, it is assumed that the vapor in the 177 radioactive waste tanks on the Hanford Project site contain a uniform mixture of gases. Several of these waste tanks (currently twenty five, 6 Double Shell Tanks and 19 Single Shell Tanks) were identified as having the potential for the buildup of gases to a flammable level. An active ventilation system in the Double Shell Tanks and a passive ventilation system in the Single Shell Tanks provides a method of expelling gases from the tanks. A gas release from a tank causes a temporary rise in the tank pressure, and a potential for increased concentration of hydrogen gas in the vapor space. The gas is released via the ventilation systems until a uniform gas mixture in the vapor space is once again achieved. This document describes the design of the Standard-B Hydrogen Monitoring System, (SHMS) and its components as it differs from the original SHMS. The differences are derived from changes made to improve the system performance but not implemented in all the installed enclosures

  12. Assessment of the relationship between standard probe and implantable fiber measurements of cortical bone blood flow: a canine study.

    Science.gov (United States)

    Jain, R; Podworny, N; Anderson, G I; Schemitsch, E H

    1996-07-01

    Laser Doppler flowmetry (LDF) has been used to assess cortical bone blood flow in various clinical situations, such as osteomyelitis and osteonecrosis. Standard metal-sheathed probes containing optical fibers, applied to cortical bone for perfusion measurements, require direct exposure of the bone surface for each measurement, making nonanesthetized assessments over time impractical. Implantable optical fibers offer a noninvasive method for evaluating cortical bone perfusion without repeated surgical exposure of the bone after initial surgical implantation of the fibers. In vitro studies have shown the reliability of laser Doppler (LD) fibers compared with those of the standard probe. This investigation studied the relationship between measurements of cortical bone perfusion obtained by implanted optical (LD) fibers and standard (LDF) probes in vivo. Midshaft tibial fractures were created in the right hindlimb of 11 adult, large (>25 kg) dogs and stabilized by low contact-dynamic compression plate fixation. Cortical bone blood flow was measured by LDF using standard probes and implantable fibers at five sites along the tibia prefracture, postfracture, immediately postplate application, and at 10 weeks postplating, immediately prior to euthanasia. The implantable fibers were secured onto the cortical bone via the plate and led through a percutaneous exit site. Histological examination of the inguinal and popliteal lymph nodes and soft tissue surrounding the fibers revealed mild inflammation. No significant correlation of blood flow assessed by the implantable fibers and standard probe occurred immediately postfracture (r 0.62). However, a statistically significant correlation was seen postplate application at one of the measurement sites in the distal fracture fragment (r = 0.78, P fibers remained intact and functional until an average of 3 weeks at which time they either fractured or were removed by the animals. This is the first in vivo study assessing the

  13. Developing IEEE medical device standards: a case study, wearable cuffless blood pressure measuring devices.

    Science.gov (United States)

    Carey, Carole C; Zhang, Yuang-Ting

    2010-01-01

    The Institute of Electrical and Electronics Engineers Standards Association (IEEE-SA) is a leading standards developing organization of global industry standards in a wide-range of industries, including biomedical and healthcare.

  14. 49 CFR 571.207 - Standard No. 207; Seating systems.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.207 Standard No. 207; Seating systems. S1. Purpose and scope. This.... Application. This standard applies to passenger cars, multipurpose passenger vehicles, trucks and buses. S3... adjuster. S4. Requirements. S4.1Driver's seat. Each vehicle shall have an occupant seat for the driver....

  15. System 80+trademark Standard Design: CESSAR design certification

    International Nuclear Information System (INIS)

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80+trademark Standard Design. This volume 8 provides a description of instrumentation and controls

  16. System 80+trademark Standard Design: CESSAR design certification

    International Nuclear Information System (INIS)

    This report, entitled Combustion Engineering Standard Safety Analysis Report - Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80+trademark Standard Design. This Volume 16 details the application of Human Factors Engineering in the design process

  17. Process Control System Cyber Security Standards - An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans; V Stanley Scown; Rolf Carlson; Shabbir Shamsuddin; George Shaw; Jeff Dagle; Paul W Oman; Jeannine Schmidt

    2005-10-01

    The use of cyber security standards can greatly assist in the protection of critical infrastructure by providing guidelines and requisite imperatives in the implementation of computer-controlled systems. These standards are most effective when the engineers and operators using the standards understand what each of the standards addresses and does not address. This paper provides a review and comparison of ten documents dealing with control system cyber security. It is not meant to be a complete treatment of all applicable standards; rather, this is an exemplary analysis showing the benefits of comparing and contrasting differing documents.

  18. Benchmarking the Naval Systems Engineering Guide against Industry Standards

    OpenAIRE

    Borchardt, Brian

    2012-01-01

    The Naval Systems Engineering Guide (NESG) was written in 2004 by representatives from NAVSEA, NAVFAC, NAVAIR, NAVSUP and MARCORSYSCOM. Since then, three other foundational systems engineering documents have been written or revised the International Standards Organization (ISO) Standard 15288 in 2008, the International Council on Systems Engineering (INCOSE) Systems Engineering Handbook in 2011, and The guide to the Systems Engineering Body of Knowledge (SEBoK) in 2012. This thesis compares t...

  19. Measurement of brachial artery endothelial function using a standard blood pressure cuff.

    Science.gov (United States)

    Maltz, Jonathan S; Tison, Geoffrey H; Alley, Hugh F; Budinger, Thomas F; Owens, Christopher D; Olgin, Jeffrey

    2015-11-01

    The integrity of endothelial function in major arteries (EFMA) is a powerful independent predictor of heart attack and stroke. Existing ultrasound-based non-invasive assessment methods are technically challenging and suitable only for laboratory settings. EFMA, like blood pressure (BP), is both acutely and chronically affected by factors such as lifestyle and medication. Consequently, laboratory-based measurements cannot fully gauge the effects of medical interventions on EFMA. EFMA and BP have, arguably, comparable (but complementary) value in the assessment of cardiovascular health. Widespread deployment of EFMA assessment is thus a desirable clinical goal. To this end, we propose a device based on modifying the measurement protocol of a standard electronic sphygmomanometer. The protocol involves inflating the cuff to sub-diastolic levels to enable recording of the pulse waveform before and after vasodilatory stimulus. The mechanical unloading of the arterial wall provided by the cuff amplifies the distension that occurs with each pulse, which is measured as a pressure variation in the cuff. We show that the height of the rising edge of each pulse is proportional to the change in lumen area between diastole and systole. This allows the effect of vasodilatory stimuli on the artery to be measured with high sensitivity. We compare the proposed cuff flow-mediated dilation (cFMD) method to ultrasound flow-mediated dilation (uFMD). We find significant correlation (r = 0.55, p = 0.003, N = 27) between cFMD- and uFMD-based metrics obtained when the release of a 5 min cuff occlusion is employed to induce endothelial stimulus via reactive hyperemia. cFMD is approximately proportional to the square of uFMD, representing a typical increase in sensitivity to vasodilation of 300-600%. This study illustrates the potential for an individual to conveniently measure his/her EFMA by using a low-cost reprogrammed home sphygmomanometer. PMID:26393958

  20. Performance Evaluation and Labeling Comprehension of a New Blood Glucose Monitoring System with Integrated Information Management

    Science.gov (United States)

    List, Susan M; Starks, Nykole; Baum, John; Greene, Carmine; Pardo, Scott; Parkes, Joan L; Schachner, Holly C; Cuddihy, Robert

    2011-01-01

    Background This study evaluated performance and product labeling of CONTOUR® USB, a new blood glucose monitoring system (BGMS) with integrated diabetes management software and a universal serial bus (USB) port, in the hands of untrained lay users and health care professionals (HCPs). Method Subjects and HCPs tested subject's finger stick capillary blood in parallel using CONTOUR USB meters; deep finger stick blood was tested on a Yellow Springs Instruments (YSI) glucose analyzer for reference. Duplicate results by both subjects and HCPs were obtained to assess system precision. System accuracy was assessed according to International Organization for Standardization (ISO) 15197:2003 guidelines [within ±15 mg/dl of mean YSI results (samples <75 mg/dl) and ±20% (samples ≥75 mg/dl)]. Clinical accuracy was determined by Parkes error grid analysis. Subject labeling comprehension was assessed by HCP ratings of subject proficiency. Key system features and ease-of-use were evaluated by subject questionnaires. Results All subjects who completed the study (N = 74) successfully performed blood glucose measurements, connected the meter to a laptop computer, and used key features of the system. The system was accurate; 98.6% (146/148) of subject results and 96.6% (143/148) of HCP results exceeded ISO 15197:2003 criteria. All subject and HCP results were clinically accurate (97.3%; zone A) or associated with benign errors (2.7%; zone B). The majority of subjects rated features of the BGMS as “very good” or “excellent.” Conclusions CONTOUR USB exceeded ISO 15197:2003 system performance criteria in the hands of untrained lay users. Subjects understood the product labeling, found the system easy to use, and successfully performed blood glucose testing. PMID:22027308

  1. The System 80+ Standard Plant Information Management System

    Energy Technology Data Exchange (ETDEWEB)

    Turk, R.S.; Bryan, R.E. [ABB Combuions Engineering Nuclear Systems (United States)

    1998-07-01

    Historically, electric nuclear power plant owners, following the completion of construction and startup, have been left with a mountain of hard-copy documents and drawings. Hundreds of thousands of hours are spent searching for relevant documents and, in most cases, the documents found require many other documents and drawings to fully understand the design basis. All too often the information is incomplete, and eventually becomes obsolete. In the U.S., utilities spend millions of dollars to discover design basis information and update as-built data for each plant. This information must then be stored in an easily accessed usable form to assist satisfy regulatory requirements and to improve plant operating efficiency. ABB Combustion Engineering Nuclear Systems (ABB-CE) has an active program to develop a state-of-the-art Plant Information Management System (IMS) for its advanced light water reactor, the System 80+TM Standard Plant Design. This program is supported by ABB's Product Data Management (PDM) and Computer Aided Engineering (CAE) efforts world wide. This paper describes the System 80+ plant IMS and how it will be used during the entire life cycle of the plant. (author)

  2. Standardization of information systems development processes and banking industry adaptations

    CERN Document Server

    Tanrikulu, Zuhal

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall life cycle model. Each question is made up of guidance and suggestions from the international system development standards. To collect data, people from the information technology departments of three major banks in Turkey were interviewed. Results have been aggregated by examining the current process status of the three banks together. Problematic issues were identified using the international system development standards.

  3. System Accuracy Evaluation of the GlucoRx Nexus Voice TD-4280 Blood Glucose Monitoring System

    OpenAIRE

    Muhammad Khan; Keith Broadbent; Mike Morris; David Ewins; Franklin Joseph

    2014-01-01

    Use of blood glucose (BG) meters in the self-monitoring of blood glucose (SMBG) significantly lowers the risk of diabetic complications. With several BG meters now commercially available, the International Organization for Standardization (ISO) ensures that each BG meter conforms to a set degree of accuracy. Although adherence to ISO guidelines is a prerequisite for commercialization in Europe, several BG meters claim to meet the ISO guidelines yet fail to do so on internal validation. We con...

  4. NREL PV System Performance and Standards Technical Progress

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C. R.

    2005-01-01

    This paper presents a brief overview of the status and accomplishments during Fiscal Year (FY)2004 of the Photovoltaic (PV) System Performance & Standards Subtask, which is part of PV Systems Engineering Project (a joint NREL-Sandia project).

  5. Efficiency of Management Systems, Based on International Standards

    Directory of Open Access Journals (Sweden)

    Elena B. Gafforova

    2012-03-01

    Full Text Available The article considers major trends of management systems standardization development and efficiency. The authors determine possible structure of effects in the process of integrated management systems implementation.

  6. 7 CFR 550.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Standards for financial management systems. 550.20... Management of Agreements Financial Management § 550.20 Standards for financial management systems. (a) REE agencies shall require Cooperators to relate financial data to performance data. (b) Cooperators'...

  7. 24 CFR 84.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... and Program Management § 84.21 Standards for financial management systems. (a) HUD shall require.... (b) Recipients' financial management systems shall provide for the following: (1) Accurate, current... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Standards for financial...

  8. 34 CFR 74.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Standards for financial management systems. 74.21... AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 74.21 Standards for financial management systems....

  9. 22 CFR 145.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards for financial management systems. 145... INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 145.21 Standards for financial management systems. (a) The...

  10. 45 CFR 74.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Standards for financial management systems. 74.21... ADMINISTRATIVE REQUIREMENTS FOR AWARDS AND SUBAWARDS TO INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER... Management § 74.21 Standards for financial management systems. (a) Recipients shall relate financial data...

  11. Cloud Computing for Standard ERP Systems

    DEFF Research Database (Denmark)

    Schubert, Petra; Adisa, Femi

    for the operation of ERP systems. We argue that the phenomenon of cloud computing could lead to a decisive change in the way business software is deployed in companies. Our reference framework contains three levels (IaaS, PaaS, SaaS) and clarifies the meaning of public, private and hybrid clouds. The three levels...... of cloud computing and their impact on ERP systems operation are discussed. From the literature we identify areas for future research and propose a research agenda....

  12. The LAN blood group system:a review.

    Science.gov (United States)

    Peyrard, Thierry

    2013-01-01

    LAN (Langereis) was officially recognized by the International Society of Blood Transfusion in 2012 as being the 33rd human blood group system. It consists of one single high-prevalence antigen,Lan (LANl). The ABCB6 protein is the carrier of the Lan blood group antigen. The ABCB6 gene (chromosome 2q36, 19 exons)encodes the ABCB6 polypeptide (ATP-binding cassette protein,subfamily B, member 6), known as a porphyrin transporter.The exceptional Lan- people do not express ABCB6 (Lan null phenotype), owing to several different molecular mechanisms affecting ABCB6: frameshift leading to a premature stop codon(deletion, insertion, or nonsense mutation of nucleotides);missense mutation; or intronic mutation responsible for RNA splicing defect. Despite the Lan antigen's being reported to play a key role in erythropoiesis and detoxification of cells, Lan people do not appear to demonstrate susceptibility to any disease or seemingly physiologic disorder. Anti-Lan has been described as having variable clinical significance, either for hemolytic transfusion reactions (none to severe) or hemolytic disease of the fetus and newborn (none to mild). Despite challenging conditions caused by the scarcity of Lan- donors worldwide, Lan- blood should ideally be given to patients with anti-Lan, especially those with a high-titer antibody.

  13. Information system life-cycle and documentation standards, volume 1

    Science.gov (United States)

    Callender, E. David; Steinbacher, Jody

    1989-01-01

    The Software Management and Assurance Program (SMAP) Information System Life-Cycle and Documentation Standards Document describes the Version 4 standard information system life-cycle in terms of processes, products, and reviews. The description of the products includes detailed documentation standards. The standards in this document set can be applied to the life-cycle, i.e., to each phase in the system's development, and to the documentation of all NASA information systems. This provides consistency across the agency as well as visibility into the completeness of the information recorded. An information system is software-intensive, but consists of any combination of software, hardware, and operational procedures required to process, store, or transmit data. This document defines a standard life-cycle model and content for associated documentation.

  14. A standard system to study vertebrate embryos.

    Directory of Open Access Journals (Sweden)

    Ingmar Werneburg

    Full Text Available Staged embryonic series are important as reference for different kinds of biological studies. I summarise problems that occur when using 'staging tables' of 'model organisms'. Investigations of developmental processes in a broad scope of taxa are becoming commonplace. Beginning in the 1990s, methods were developed to quantify and analyse developmental events in a phylogenetic framework. The algorithms associated with these methods are still under development, mainly due to difficulties of using non-independent characters. Nevertheless, the principle of comparing clearly defined newly occurring morphological features in development (events in quantifying analyses was a key innovation for comparative embryonic research. Up to date no standard was set for how to define such events in a comparative approach. As a case study I compared the external development of 23 land vertebrate species with a focus on turtles, mainly based on reference staging tables. I excluded all the characters that are only identical for a particular species or general features that were only analysed in a few species. Based on these comparisons I defined 104 developmental characters that are common either for all vertebrates (61 characters, gnathostomes (26, tetrapods (3, amniotes (7, or only for sauropsids (7. Characters concern the neural tube, somite, ear, eye, limb, maxillary and mandibular process, pharyngeal arch, eyelid or carapace development. I present an illustrated guide listing all the defined events. This guide can be used for describing developmental series of any vertebrate species or for documenting specimen variability of a particular species. The guide incorporates drawings and photographs as well as consideration of species identifying developmental features such as colouration. The simple character-code of the guide is extendable to further characters pertaining to external and internal morphological, physiological, genetic or molecular development, and

  15. Standard Data Exchanges for Distribution System Management

    Energy Technology Data Exchange (ETDEWEB)

    Thomas E. McDermott

    2007-10-05

    Databases and software tools for electric power distribution systems have not been integrated, and this leads to extra costs and restrictions imposed on utilities and other stakeholders. For example, distributed resource integration studies and modern grid technology assessments are more difficult and costly. New vendors face high market entry barriers, because it’s necessary to interface with large and customized data systems at each potential utility customer. This project promotes data and software tool integration, through a set of data translators based on a common object model. The data translators are delivered as open-source software, using appropriate Web software technologies. The parties who benefit include electric utilities (and their ratepayers), researchers at government laboratories and universities, small software companies wishing to enter the electric utility market, and parties wishing to interconnect distributed generation to a utility system.

  16. Anthropometric correlates reaction of cardiovascular system for standard exercise stress athletes playing sports

    OpenAIRE

    Guziy, O. V.; Romanchuk, A.P.

    2014-01-01

    The article provides a comparative analysis of anthropometric and functional parameters of the cardiovascular system 207 skilled male athletes involved in team sports (basketball, water polo, volleyball, handball, football). A correlation analysis between the parameters of physical development and growth rates of heart rate and blood pressure in response to a standard exercise stress (test-Martine Kushelevsky). It is shown that in various team sports and characteristic relationship between...

  17. Test System for Standard ALICE DCS Components

    CERN Document Server

    AUTHOR|(CDS)2160773

    2016-01-01

    Currently, the ALICE DCS project is supervising equipment installed in the ALICE experiment site at CERN. Hence, the aim of this project was to provide a test bench in the DCS lab, where a real equipment and software tools will be deployed. Using this test bench, test procedures which exercise the devices under the test in a configurable way and provide logging and trending of the acquired data were implemented. The setup was devised using the ALICE software framework and Siemens SCADA system WINCC OA, providing the same functionality as the systems installed in ALICE, and will be used for the commissioning of the new software and hardware, burn-in tests of new modules and log-term stability tests of ALICE hardware.

  18. Help for the Developers of Control System Cyber Security Standards

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans

    2008-05-01

    A Catalog of Control Systems Security: Recommendations for Standards Developers (Catalog), aimed at assisting organizations to facilitate the development and implementation of control system cyber security standards, has been developed. This catalog contains requirements that can help protect control systems from cyber attacks and can be applied to the Critical Infrastructures and Key Resources of the United States and other nations. The requirements contained in the catalog are a compilation of practices or various industry bodies used to increase the security of control systems from both physical and cyber attacks. They should be viewed as a collection of recommendations to be considered and judiciously employed, as appropriate, when reviewing and developing cyber security standards for control systems. The recommendations in the Catalog are intended to be broad enough to provide any industry using control systems the flexibility needed to develop sound cyber security standards specific to their individual security requirements.

  19. Management system - correlation study between new IAEA standards and the market standards

    International Nuclear Information System (INIS)

    In order to answer the growing concern of society with respect of the aspects that affect the quality of life, international and national regulatory bodies have developed standards that enable organizations to establish management systems for quality, environment and sustainable development, health, safety and social responsibility, among other functions. Within this context it is necessary to structure an integrated management system that promotes interests compatibility of several distinct and complementary functions involved. Considering this vision of the management system integration, the International Atomic Energy Agency (IAEA) decided to review the structure of safety standards on Quality Assurance - code and guides 50-C/SGQ1/ 14:1996, publishing, in 2006, IAEA GS-R-3 and IAEA GS-G-3.1 standards, enlarging the management approach of the previous standards, including the possibility of integrating the functions foremost mentioned. This paper presents the results about a correlation study between IAEA management system standards - IAEA GS-R-3: 2006, IAEA GS-G-3.1: 2006 and IAEA DS349 rev. 2007, this latter still a draft standard, with those market management system standards on quality - ISO 9001:2008, environmental - ISO 14001:2004, and occupational health and safety - BS OHSAS 18001:2007, identifying gaps, redundancies and complementarities among their requirements and guidances. The purpose of the study is to provide subsidies that could contribute to the structuring of a management system to nuclear facilities that satisfies, in an integrated manner, the common and complementary requirements and guidances of IAEA and market standards. (author)

  20. Management system - correlation study between new IAEA standards and the market standards

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Dirceu Paulo de [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), Ipero, SP (Brazil)], e-mail: dirceupo@hotmail.com; Zouain, Desiree Moraes [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)], e-mail: dmzouain@ipen.br

    2009-07-01

    In order to answer the growing concern of society with respect of the aspects that affect the quality of life, international and national regulatory bodies have developed standards that enable organizations to establish management systems for quality, environment and sustainable development, health, safety and social responsibility, among other functions. Within this context it is necessary to structure an integrated management system that promotes interests compatibility of several distinct and complementary functions involved. Considering this vision of the management system integration, the International Atomic Energy Agency (IAEA) decided to review the structure of safety standards on Quality Assurance - code and guides 50-C/SGQ1/ 14:1996, publishing, in 2006, IAEA GS-R-3 and IAEA GS-G-3.1 standards, enlarging the management approach of the previous standards, including the possibility of integrating the functions foremost mentioned. This paper presents the results about a correlation study between IAEA management system standards - IAEA GS-R-3: 2006, IAEA GS-G-3.1: 2006 and IAEA DS349 rev. 2007, this latter still a draft standard, with those market management system standards on quality - ISO 9001:2008, environmental - ISO 14001:2004, and occupational health and safety - BS OHSAS 18001:2007, identifying gaps, redundancies and complementarities among their requirements and guidances. The purpose of the study is to provide subsidies that could contribute to the structuring of a management system to nuclear facilities that satisfies, in an integrated manner, the common and complementary requirements and guidances of IAEA and market standards. (author)

  1. Disability standards and guidelines for learning management systems: Evaluating accessibility

    OpenAIRE

    Moreno, Lourdes; Iglesias, Ana; Calvo, Rocío; Delgado, Sandra; Zaragoza, Luis

    2012-01-01

    Currently, the great majority of institutions of higher education use Learning Content Management Systems (LCMSs) and Learning Management Systems (LMS) as pedagogical tools. In order to make these systems accessible to all students, it is important to take into account not only educational standards, but also standards of accessibility. It is essential to have with procedures and well-established method for evaluating these tools, so in this paper we propose a method for evaluatin...

  2. 78 FR 77574 - Protection System Maintenance Reliability Standard

    Science.gov (United States)

    2013-12-24

    ... protection system, ``resulting in line relays being placed in service with the incorrect transformer ratio.... 824o (2012). \\2\\ Mandatory Reliability Standards for the Bulk Power System, Order No. 693, 72 FR 16,416... commissioning of power system protection systems.\\55\\ NERC commits in its Comments to keep the...

  3. 40 CFR 35.6270 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... of the adequacy of the financial management system as described in 40 CFR 31.20(c). (2) Allowable... § 35.6270 Standards for financial management systems. (a) Accounting system standards—(1) General. The... 40 CFR 31.22. (3) Pre-remedial. The system need not track expenses by site. However, all...

  4. Standardization of Social Credit System Initiated in China

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Introduction The current government advances that the order of market economy should be standardized and the social credit system of market economy in modern times should be established and completed. The social credit system should be formed on the basis of property right, supported by moral and high consciousness of social credit. Therefore, the basic framework and operation mechanism of the standards system for social credit will be established in 5 years in China in order to make standards play an important role in a regular market and the aspect of credit management, to improve administration's compliance with the regulation, and to facilitate the market economic order.

  5. Quantitative photoacoustic blood oxygenation measurement of whole porcine blood samples using a multi-wavelength semiconductor laser system

    Science.gov (United States)

    Friedrich, Claus-Stefan; Mienkina, Martin P.; Brenner, Carsten; Gerhardt, Nils C.; Jörger, Manfred; Strauß, Andreas; Beckmann, Martin F.; Schmitz, Georg; Hofmann, Martin R.

    2011-07-01

    We present a photoacoustic measurement system based on semiconductor lasers for blood oxygenation measurements. It permits to use four different optical wavelengths (650nm, 808nm, 850nm, 905nm) to generate photoacoustic signals. As the optical extinction coefficient of oxygenated hemoglobin and deoxygenated hemoglobin is different at specific wavelengths, a blood oxygenation measurement by a multi-wavelength photoacoustic laser system is feasible. Especially at 650nm, the clear difference between the extinction coefficients of the two hemoglobin derivates permits to determine the blood oxygenation in combination with other near infrared wavelengths. A linear model based on tabulated values of extinction coefficients for fully oxygenated and fully deoxygenated hemoglobin is presented. We used heparin stabilized whole porcine blood samples to model the optical behavior of human blood, as the optical absorption behavior of porcine hemoglobin does not differ significantly from human hemoglobin. To determine the real oxygen saturation values of the blood samples, we measured the partial oxygen pressure with an IRMA Trupoint Blood Analysis System. The oxygen saturation values were calculated from a dissociation curve for porcine blood. The results of the photoacoustic measurement are in qualitatively good agreement with the predicted linear model. Further, we analyze the abilities and the limitations of quantitative oxygenation measurements.

  6. Quantitative analysis of carisoprodol and meprobamate in whole blood using benzylcarbamate and deuterated meprobamate as internal standards.

    Science.gov (United States)

    Downey, Delisa; Simons, Kelsie; Ota, Kenji; Kerrigan, Sarah

    2009-06-01

    Carisoprodol and meprobamate are frequently encountered drugs in impaired driving casework. Deuterated internal standards, although preferred, were not available until recently. Earlier published studies report the use of a variety of non-deuterated internal standards, many of which lack the chemical and physical similarities that are desired for quantitative analysis. Carisoprodol and meprobamate were determined in whole blood using solid-phase extraction and gas chromatography-mass spectrometry with benzylcarbamate and meprobamate-d(7) as internal standards. When benzylcarbamate was used as internal standard, the linear ranges for carisoprodol and meprobamate were 0-20 mg/L and 0-40 mg/L, respectively. The linear range increased to 100 mg/L when meprobamate-d(7) was used. Limits of detection for carisoprodol and meprobamate were 0.2 and 0.4 mg/L, respectively, regardless of the internal standard selection. The limit of quantitation for both drugs using either internal standard was 0.4 mg/L. Accuracies using benzylcarbamate and meprobamate-d(7) were 100-106% and 91-100%, respectively. Corresponding values for precision indicated intra-assay coefficients of variation of 2.6-4.3% for benzylcarbamate and 1.0-2.3% for meprobamate-d(7). No carryover was evident at 100 mg/L, the highest concentration tested, and no interferences were observed. Results indicated that either benzylcarbamate or meprobamate-d(7) is a suitable internal standard for quantitative determination of carisoprodol or meprobamate from whole blood. PMID:19671248

  7. The New Standards System for Processing Food to Be Proved

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ It is reported that the work of re-structuring the frame of China national standards system for processing food has been finished with the print and distribution of 2004-2005 Development Plan of National Standards for Food (hereinafter Plan).

  8. 22 CFR 518.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Standards for financial management systems. 518... REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 518.21 Standards for...

  9. 40 CFR 30.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 30.21 Standards for financial management systems. (a) EPA shall require recipients to... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Standards for financial...

  10. Noninvasive biosensor and wireless interrogating system for glucose in blood

    Science.gov (United States)

    Varadan, Vijay K.; Whitchurch, Ashwin K.; Sarukesi, K.

    2003-07-01

    Hypoglycemia-abnormal decrease in blood sugar-is a major obstacle in the management of diabetes and prevention of long-term complications, and it may impose serious effects on the brain, including impairment of memory and other cognitive functions. This paper presents the development of a non-invasive sensor with miniaturized telemetry device in a wrist-watch for monitoring glucose concentration in blood. The sensor concept is based on optical chirality of glucose level in the interstitial fluid. The wrist watch consists of a laser power source of the wavelength compatible with the glucose. A nanofilm with specific chirality is placed at the bottom of the watch. The light then passes through the film and illuminates a small area on the skin. It has been documented that there is certain concentration of sugar level is taken by the intertitial fluid from the blood stream and deposit a portion of it at the dead skin. The wrist-watch when in contact with the outer skin of the human will thus monitor the glucose concentration. A wireless monitoring system in the watch then downloads the data from the watch to a Palm or a laptop computer.

  11. Recommendations for a standard UK approach to incorporating umbilical cord blood into clinical transplantation practice: an update on cord blood unit selection, donor selection algorithms and conditioning protocols.

    Science.gov (United States)

    Hough, Rachael; Danby, Robert; Russell, Nigel; Marks, David; Veys, Paul; Shaw, Bronwen; Wynn, Rob; Vora, Ajay; Mackinnon, Stephen; Peggs, Karl S; Crawley, Charles; Craddock, Charlie; Pagliuca, Antonio; Cook, Gordon; Snowden, John A; Clark, Andrew; Marsh, Judith; Querol, Sergio; Parkes, Guy; Braund, Henny; Rocha, Vanderson

    2016-02-01

    Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. Donor choice may be further complicated by other important factors, such as urgency of transplant, the presence of alloantibodies, the disease status (homozygosity or heterozygosity) of sibling donors affected by inherited disorders and the cytomegalovirus serostatus of patient and donor. We report UK consensus guidelines on the selection of umbilical cord blood units, the hierarchy of donor selection and the preferred conditioning regimens for umbilical cord blood transplantation, with a summary of rationale supporting these recommendations. PMID:26577457

  12. Characterizing Digital Camera Systems: A Prelude to Data Standards

    Science.gov (United States)

    Ryan, Robert

    2002-01-01

    This viewgraph presentation profiles: 1) Digital imaging systems; 2) Specifying a digital imagery product; and 3) Characterization of data acquisition systems. Advanced large array digital imaging systems are routinely being used. Digital imagery guidelines are being developed by ASPRS and ISPRS. Guidelines and standards are of little use without standardized characterization methods. Characterization of digital camera systems is important for supporting digital imagery guidelines. Specifications are characterized in the lab and/or the field. Laboratory characterization is critical for optimizing and defining performance. In-flight characterization is necessary for an end-to-end system test.

  13. Patterns in Standards and Technologies for Economic Information Systems Interoperability

    Directory of Open Access Journals (Sweden)

    Vasile Irimia

    2012-06-01

    Full Text Available This paper presets results from a review of the current standards used for collaboration between economic information systems, including web services and service oriented architecture, EDI, ebXML framework, RosettaNet framework, cXML, xCBL UBL, BPMN, BPEL, WS-CDL, ASN.1, and others. Standards have a key role in promoting economic information system interoperability, and thus enable collaboration. Analyzing the current standards, technologies and applications used for economic information systems interoperability has revealed a common pattern that runs through all of them. From this pattern we construct a basic model of interoperability around which we relate and judge all standards, technologies and applications for economic information systems interoperability.

  14. 21 CFR 864.9175 - Automated blood grouping and antibody test system.

    Science.gov (United States)

    2010-04-01

    ...) Identification. An automated blood grouping and antibody test system is a device used to group erythrocytes (red blood cells) and to detect antibodies to blood group antigens. (b) Classification. Class II (performance... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Automated blood grouping and antibody test...

  15. Oscillometric continuous blood pressure sensing for wearable health monitoring system

    CERN Document Server

    Gelao, Gennaro; Passaro, Vittorio M N; Perri, Anna Gina

    2015-01-01

    In this paper we present an acquisition chain for the measurement of blood arterial pressure based on the oscillometric method. This method does not suffer from any limitation as the well-known auscultatory method and it is suited for wearable health monitoring systems. The device uses a pressure sensor whose signal is filtered, digitalized and analyzed by a microcontroller. Local analysis allows the evaluation of the systolic and diastolic pressure values which can be used for local alarms, data collection and remote monitoring.

  16. 32 CFR 34.11 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... ORGANIZATIONS Post-award Requirements Financial and Program Management § 34.11 Standards for financial... systems established for doing business in the commercial marketplace, to the extent that the systems... a minimum, a recipient's financial management system shall provide: (1) Effective control of...

  17. 24 CFR 85.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... Administration § 85.20 Standards for financial management systems. (a) A State must expand and account for grant... statutes. (b) The financial management systems of other grantees and subgrantees must meet the following... agency may review the adequacy of the financial management system of any applicant for...

  18. 10 CFR 600.121 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Standards for financial management systems. 600.121... financial management systems. (a) Recipients shall relate financial data to performance data and develop....121(f) and 600.181, recipients' financial management systems shall provide for the following:...

  19. 36 CFR 1207.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... financial management systems. (a) A State must expand and account for grant funds in accordance with State... management systems of other grantees and subgrantees must meet the following standards: (1) Financial... the financial management system of any applicant for financial assistance as part of a preaward...

  20. 45 CFR 2541.200 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Standards for financial management systems. 2541... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems... the financial management system of any applicant for financial assistance as part of a preaward...

  1. Standardized intermittent static exercise increases peritendinous blood flow in human leg

    DEFF Research Database (Denmark)

    Langberg, Henning; Bülow, J; Kjaer, M

    1999-01-01

    radioactive isotope xenon-133 was injected just ventrally to the Achilles tendon 5 cm proximal to the tendon's insertion on the calcaneous. The disappearance of 133Xe was used to determine blood flow during intermittent static exercise of the calf muscle (1.5 s exercise/1.5 s rest) for 30 min at a workload...

  2. Employing Industry Standards for System Integration in Digital Radiology Department

    Institute of Scientific and Technical Information of China (English)

    Yongjian Bao

    2004-01-01

    This paper reviews system inte-gration needs in a digital radiologydepartment, and open industry stan-dards developed in the past twodecades to address these needs. In par-ticular, the Integrating the HospitalEnterprise (IHE) initiative defines aset of Integration Profiles in radiolo-gy, with a focus on the interoperabili-ty of the integrated systems, based onexisting industry standards, such asDICOM and HL7.

  3. Development of inexpensive blood imaging systems: where are we now?

    Science.gov (United States)

    Chu, Kaiqin; Smith, Zachary J; Wachsmann-Hogiu, Sebastian

    2015-01-01

    Clinical applications in the developing world, such as malaria and anemia diagnosis, demand a change in the medical paradigm of expensive care given in central locations by highly trained professionals. There has been a recent explosion in optical technologies entering the consumer market through the widespread adoption of smartphones and LEDs. This technology commoditization has enabled the development of small, portable optical imaging systems at an unprecedentedly low cost. Here, we review the state-of-the-field of the application of these systems for low-cost blood imaging with an emphasis on cellular imaging systems. In addition to some promising results addressing specific clinical issues, an overview of the technology landscape is provided. We also discuss several key issues that need to be addressed before these technologies can be commercialized. PMID:26305840

  4. Development of inexpensive blood imaging systems: where are we now?

    Science.gov (United States)

    Chu, Kaiqin; Smith, Zachary J; Wachsmann-Hogiu, Sebastian

    2015-01-01

    Clinical applications in the developing world, such as malaria and anemia diagnosis, demand a change in the medical paradigm of expensive care given in central locations by highly trained professionals. There has been a recent explosion in optical technologies entering the consumer market through the widespread adoption of smartphones and LEDs. This technology commoditization has enabled the development of small, portable optical imaging systems at an unprecedentedly low cost. Here, we review the state-of-the-field of the application of these systems for low-cost blood imaging with an emphasis on cellular imaging systems. In addition to some promising results addressing specific clinical issues, an overview of the technology landscape is provided. We also discuss several key issues that need to be addressed before these technologies can be commercialized.

  5. New method for rapid Susceptibility Testing on blood culture with HB&L system: preliminary data

    Directory of Open Access Journals (Sweden)

    Vincenzo Rondinelli

    2010-12-01

    Full Text Available Blood culture, although represents the gold standard in detecting the ethiological agent of sepsis, is rather rarely required in relation to the real diagnostic importance. The result of this test depends in fact on many factors (sample volume, time of collection, accuracy, antibiotic therapy, contamination, number of drawings, drawing site, interpretation difficulties, etc. that are often considered by many clinicians so limited as to doubt about their actual value. The disadvantages are therefore represented by the lack of standardization but also by the low sensitivity and above all by the technical times too long for the clinical needs. Blood culture begins with the drawing of samples from the “septic” patient followed incubation of the bottles in automatic thermostated systems. In case of positive result (36 hours, the culture is Gram stained and streaked on solid media in order to obtain isolated colonies for the identification and the susceptibility testing (48 hours from positive result. The long time required for pathogen identification and susceptibility testing involves empirical broad spectrum antibiotic therapy that can promote the increase of bacterial resistance but also patient management costs. A clinically useful report should be available on short notice in order to guide the clinician to choose the most appropriate antibiotic. The microbiologist has therefore the hard work of reviewing the organization and the management of the procedures.We have therefore started to consider the possibility of treating the blood as an biological liquid in order to quickly determine the susceptibility of bacteria to antibiotics.

  6. Rarefaction and blood pressure in systemic and pulmonary arteries.

    Science.gov (United States)

    Olufsen, Mette S; Hill, N A; Vaughan, Gareth D A; Sainsbury, Christopher; Johnson, Martin

    2012-08-01

    The effects of vascular rarefaction (the loss of small arteries) on the circulation of blood are studied using a multiscale mathematical model that can predict blood flow and pressure in the systemic and pulmonary arteries. We augmented a model originally developed for the systemic arteries (Olufsen et al. 1998, 1999, 2000, 2004) to (a) predict flow and pressure in the pulmonary arteries, and (b) predict pressure propagation along the small arteries in the vascular beds. The systemic and pulmonary arteries are modelled as separate, bifurcating trees of compliant and tapering vessels. Each tree is divided into two parts representing the `large' and `small' arteries. Blood flow and pressure in the large arteries are predicted using a nonlinear cross-sectional area-averaged model for a Newtonian fluid in an elastic tube with inflow obtained from magnetic resonance measurements. Each terminal vessel within the network of the large arteries is coupled to a vascular bed of small `resistance' arteries, which are modelled as asymmetric structured trees with specified area and asymmetry ratios between the parent and daughter arteries. For the systemic circulation, each structured tree represents a specific vascular bed corresponding to major organs and limbs. For the pulmonary circulation, there are four vascular beds supplied by the interlobar arteries. This manuscript presents the first theoretical calculations of the propagation of the pressure and flow waves along systemic and pulmonary large and small arteries. Results for all networks were in agreement with published observations. Two studies were done with this model. First, we showed how rarefaction can be modelled by pruning the tree of arteries in the microvascular system. This was done by modulating parameters used for designing the structured trees. Results showed that rarefaction leads to increased mean and decreased pulse pressure in the large arteries. Second, we investigated the impact of decreasing vessel

  7. [Satisfaction survey in general hospital personnel involved in blood transfusion: implementation of the ISO 9001: 2000 standard].

    Science.gov (United States)

    Chord-Auger, S; de Bouchony, E Tron; Moll, M-C; Boudart, D; Folléa, G

    2004-07-01

    As part of its policy of constant quality improvement, Etablissement Français du Sang (EFS) des Pays de la Loire (Pays de la Loire Regional blood transfusion institution) carried out a satisfaction survey among the hospital personnel involved in prescribing and using immuno-hematological tests and labile blood products. The polling tool selected by agreement between the hospital management and quality assurance department was a questionnaire that permitted item rating and free commentary. It addressed the personnel's perception of the quality of erythrocyte immuno-hematological (EIH) testing and of the products administered, as well as their perception of the quality of communications with the local EFS. The questionnaire was sent to 26 physicians and 32 senior nurses in 15 hospital departments. The reply rate was 60% and expressed a 85% overall satisfaction level. Dissatisfaction causes were more specifically analysed, the main one involving labile blood product distribution in emergency situations. A joint undertaking by the EFS and the hospital led to the implementation of corrective measures, including the writing and implementation of a common standard operating procedure for emergency transfusion management. The results obtained demonstrated the feasibility of this type of survey and the interest, to a blood transfusion centre and the hospital personnel involved in transfusion, of assessing their very own perception of service quality.

  8. Measurement of brachial artery endothelial function using a standard blood pressure cuff

    OpenAIRE

    Maltz, Jonathan S.; Tison, Geoffrey H; Alley, Hugh F.; Budinger, Thomas F; Owens, Christopher D.; Olgin, Jeffrey

    2015-01-01

    The integrity of endothelial function in major arteries (EFMA) is a powerful independent predictor of heart attack and stroke. Existing ultrasound-based non-invasive assessment methods are technically challenging and suitable only for laboratory settings. EFMA, like blood pressure (BP), is both acutely and chronically affected by factors such as lifestyle and medication. Consequently, lab-based measurements cannot fully gauge the effects of medical interventions on EFMA. EFMA and BP have, arg...

  9. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis

    OpenAIRE

    Yingyan Yu; Zhenggang Zhu; Jun Zhang; Min Yan; Bingya Liu; Jianian Zhang; Jun Ji; Zhiwei Wang; Lei Liu

    2012-01-01

    This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for m...

  10. Systems biology of stored blood cells: Can it help to extend the expiration date?

    OpenAIRE

    Paglia, Giuseppe; Bernhard Ø Palsson; Sigurjonsson, Olafur E.

    2012-01-01

    With increasingly stringent regulations regarding deferral and elimination of blood donors it will become increasingly important to extend the expiration date of blood components beyond the current allowed storage periods. One reason for the storage time limit for blood components is that platelets and red blood cells develop a condition called storage lesions during their storage in plastic blood containers. Systems biology provides comprehensive bio-chemical descriptions of organisms throug...

  11. Developing and enforcing internal information systems standards: InduMaker’s Standards Management Process

    Directory of Open Access Journals (Sweden)

    Claudia Loebbecke

    2016-01-01

    Full Text Available It is widely agreed that standards provide numerous benefits when available and enforced. Company-internal Information Systems (IS management procedures and solutions, in the following coined IS ‘standards’, allow for harmonizing operations between company units, locations and even different service providers. However, many companies lack an organized process for defining and managing internal IS standards, which causes uncertainties and delays in decision making, planning, and design processes. In this case study of the globally operating InduMaker (anonymized company name, an established manufacturing supplier, we look into the company-internal management of IS standards. Theoretically grounded in the organizational and IS-focused literature on business process modelling and business process commoditization, we describe and investigate InduMaker’s newly developed Standard Management Process (SMP for defining and managing company-internal business and IS standards, with which the multinational pursues offering clear answers to business and IT departments about existing IS standards, their degree of obligation, applicability, and scope at any time.

  12. Standards for the testing and evaluation of seismic isolation systems

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, A.W.; Chung, R.M. [National Inst. of Standards and Technology, Gaithersburg, MD (United States). Building and Fire Research Lab.; Shenton, H.W. [Univ. of Delaware, Newark, DE (United States). Dept. of Civil Engineering

    1995-12-01

    Draft guidelines for the testing and evaluation of seismic isolation systems have recently been developed at the National Institute of Standards and Technology (NIST). These guidelines are organized into three sections: pre-qualification, prototype, and quality control testing. The guidelines are broadly applicable, since they are independent of the type of isolation system and superstructure. The guidelines will serve as a resource document for industry, and as a basis for developing future standards for testing of isolation systems. This paper gives an overview of the NIST draft guidelines, emphasizing the philosophy behind the development of the guidelines. A brief summary of the contents of the guidelines is also presented.

  13. Codes, standards, and PV power systems. A 1996 status report

    Energy Technology Data Exchange (ETDEWEB)

    Wiles, J

    1996-06-01

    As photovoltaic (PV) electrical power systems gain increasing acceptance for both off-grid and utility-interactive applications, the safety, durability, and performance of these systems gains in importance. Local and state jurisdictions in many areas of the country require that all electrical power systems be installed in compliance with the requirements of the National Electrical Code{reg_sign} (NEC{reg_sign}). Utilities and governmental agencies are now requiring that PV installations and components also meet a number of Institute of Electrical and Electronic Engineers (IEEE) standards. PV installers are working more closely with licensed electricians and electrical contractors who are familiar with existing local codes and installation practices. PV manufacturers, utilities, balance of systems manufacturers, and standards representatives have come together to address safety and code related issues for future PV installations. This paper addresses why compliance with the accepted codes and standards is needed and how it is being achieved.

  14. 13 CFR 143.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... Requirements Financial Administration § 143.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... advances to the grantees. (c) An awarding agency may review the adequacy of the financial management...

  15. 28 CFR 66.20 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... Requirements Financial Administration § 66.20 Standards for financial management systems. (a) A State must... prohibitions of applicable statutes. (b) The financial management systems of other grantees and subgrantees... advances to the grantees. (c) An awarding agency may review the adequacy of the financial management...

  16. 36 CFR 1210.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 1210.21 Standards for financial management systems. (a) The NHPRC shall require.... (b) Recipients' financial management systems shall provide for the following. (1) Accurate,...

  17. 38 CFR 49.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management § 49.21 Standards for financial management systems. (a) Federal awarding agencies shall... practical. (b) Recipients' financial management systems shall provide for the following. (1)...

  18. 40 CFR 63.689 - Standards: Transfer systems.

    Science.gov (United States)

    2010-07-01

    ...-permanently sealed (e.g., a welded joint between two sections of metal pipe or a bolted and gasketed flange....689 Standards: Transfer systems. (a) The provisions of this section apply to the control of air... section for such air emission control. (b) For each transfer system that is subject to this section and...

  19. Standard review plan for dry cask storage systems. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The Standard Review Plan (SRP) For Dry Cask Storage Systems provides guidance to the Nuclear Regulatory Commission staff in the Spent Fuel Project Office for performing safety reviews of dry cask storage systems. The SRP is intended to ensure the quality and uniformity of the staff reviews, present a basis for the review scope, and clarification of the regulatory requirements. Part 72, Subpart B generally specifies the information needed in a license application for the independent storage of spent nuclear fuel and high level radioactive waste. Regulatory Guide 3.61 {open_quotes}Standard Format and Content for a Topical Safety Analysis Report for a Spent Fuel Dry Storage Cask{close_quotes} contains an outline of the specific information required by the staff. The SRP is divided into 14 sections which reflect the standard application format. Regulatory requirements, staff positions, industry codes and standards, acceptance criteria, and other information are discussed.

  20. The proposed combustion standards and DOE thermal treatment systems

    Energy Technology Data Exchange (ETDEWEB)

    McFee, J. [IT Corp. (United States); Hinman, M.B. [Carter and Hinman, P.A. (United States); Eaton, D.; NcNeel, K. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States)

    1997-08-01

    Under the provisions of the Clean Air Act (CAA) concerning emission of hazardous air pollutants (HAPs), the Environmental Protection Agency (EPA) published the proposed Revised Standards for Hazardous Waste Combustors on April 19, 1996 (EPA, 1996). These standards would apply to the existing Department of Energy (DOE) radioactive and mixed waste incinerators, and may be applied to several developing alternatives to incineration. The DOE has reviewed the basis for these regulations and prepared extensive comments to present concerns about the bases and implications of the standards. DOE is now discussing compliance options with the EPA for regulation of radioactive and mixed waste thermal treatment systems.

  1. Improving Collaboration by Standardization Efforts in Systems Biology

    OpenAIRE

    Dräger, Andreas; Palsson, Bernhard Ø.

    2014-01-01

    Collaborative genome-scale reconstruction endeavors of metabolic networks would not be possible without a common, standardized formal representation of these systems. The ability to precisely define biological building blocks together with their dynamic behavior has even been considered a prerequisite for upcoming synthetic biology approaches. Driven by the requirements of such ambitious research goals, standardization itself has become an active field of research on nearly all levels of gran...

  2. Understanding information retrieval systems management, types, and standards

    CERN Document Server

    Bates, Marcia J

    2011-01-01

    In order to be effective for their users, information retrieval (IR) systems should be adapted to the specific needs of particular environments. The huge and growing array of types of information retrieval systems in use today is on display in Understanding Information Retrieval Systems: Management, Types, and Standards, which addresses over 20 types of IR systems. These various system types, in turn, present both technical and management challenges, which are also addressed in this volume. In order to be interoperable in a networked environment, IR systems must be able to use various types of

  3. How should Canada fund the blood system? An evaluation of the chargeback proposal.

    Science.gov (United States)

    Wilson, Kumanan; MacDougall, Laura; Pinard, Brigitte; Amin, Mohammad A; Fergusson, Dean; Graham, Ian; Blajchman, Morris; Freedman, John; Angus, Doug; Hébert, Paul C

    2003-01-01

    The Canadian blood system is a critical interface between public health and the delivery of patient care. The organization of the blood system plays a vital role in ensuring that its functions are effectively fulfilled. Previous structural problems in the blood system led to serious health consequences by contributing to the blood transmission of hepatitis C and HIV in the 1980s. To address these problems, the Canadian blood system has recently undergone considerable organizational reform. However, policy-makers, particularly in Ontario, are considering further structural reform specifically focusing on how the blood system is financed. This move for reform is partially motivated by the rising cost of blood products and the perception that the current system has failed to provide incentives for the efficient use of these products. The suggested payment mechanism, a "chargeback system," involves the provincial ministries of health funding hospitals so that hospitals can directly purchase blood products from the Canadian Blood Services. This approach would replace the current system in which the provinces directly fund the Canadian Blood Services, which in turn provides blood products free of charge to hospitals. Based on a review of documents and stakeholder interviews, we report the potential advantages and disadvantages of a change to a new system of funding and make recommendations on how provinces should proceed. PMID:12846144

  4. Portable real time analysis system for regional cerebral blood flow

    International Nuclear Information System (INIS)

    A very portable, regional cerebral blood flow (rCBF) analysis instrument system suitable for use in the operating theater during surgery is under development. Cadmium telluride (CdTe) solid state radiation detectors, an 8086 based data acquisition and communications module and a DEC Microvax computer are used so that the instrument is very compact, yet has the computational power to provide real time data analysis in the clinical environment. The instrument is currently being used at Bowman Gray School of Medicine to study rCBF during cardiopulmonary bypass surgery (CPB). Preliminary studies indicate that monitoring rCBF during this surgical procedure may provide insights into the mechanism that causes a significant fraction of these patients to suffer post operative neuropsychological deficit

  5. Portable real time analysis system for regional cerebral blood flow

    Energy Technology Data Exchange (ETDEWEB)

    Tiernan, T.; Entine, G.; Stump, D.A.; Prough, D.S.

    1988-02-01

    A very portable, regional cerebral blood flow (rCBF) analysis instrument system suitable for use in the operating theater during surgery is under development. Cadmium telluride (CdTe) solid state radiation detectors, an 8086 based data acquisition and communications module and a DEC Microvax computer are used so that the instrument is very compact, yet has the computational power to provide real time data analysis in the clinical environment. The instrument is currently being used at Bowman Gray School of Medicine to study rCBF during cardiopulmonary bypass surgery (CPB). Preliminary studies indicate that monitoring rCBF during this surgical procedure may provide insights into the mechanism that causes a significant fraction of these patients to suffer post operative neuropsychological deficit.

  6. Quality assurance: Importance of systems and standard operating procedures

    OpenAIRE

    Kishu Manghani

    2011-01-01

    It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality...

  7. Optimization of sugar and blood feeding regimen in Anopheles gambiae mass production system

    International Nuclear Information System (INIS)

    The sterile insect technique (SIT) is being developed for the control of malaria transmitting mosquitoes. Critical to the success of applying the SIT is the establishment of standardized mass production systems for the target species. As part of efforts to develop standardised mass production systems for malaria vectors, this project sought to optimize adult blood and sugar feeding in a mass production system. Different sugar types (glucose, sucrose and honey) were evaluated at 6% and 10% concentrations in water to determine the best sugar diet and concentration for feeding adult An. gambiae. Different blood feeding methods, restrained Guinea pig, anaesthetised Guinea pig and human arm feeding were evaluated. Adult survival, female insemination and egg production were used as criteria to determine optimum sugar and blood feeding. The effect of anaesthetics on blood feeding response and egg production of female An. gambiae was determined by comparing feeding response and egg production of females fed with anaesthetised Guinea pigs as against physically restrained Guinea pigs (Control). The specific effect of different anaesthetic agents on blood feeding response and egg production of female mosquitoes were was also determined by comparing the feeding response and egg production of females fed with either Ketamine/Xylazine anaesthetised Guinea pigs or Ketamine/Diazepam anaesthetised Guinea pigs. Effects due to sugar types and concentrations on percentage survival of male and female mosquitoes were observed to be significant at (p 0.05). However, human ann feeding (HAP) method and Ketamine/Xylazine (KX) anaesthetics fed for 25 minutes recorded higher percentage feeding (76.0% and 68.0% respectively) and egg production of 19.0% and 20.8% respectively. Anaesthetised Guinea pig feeding (AGF) of adults for 15 minutes followed closely with 60.0% and 15.1% blood feeding and egg production respectively whilst restrained Guinea pig feeding (RGF) method and Ketamine

  8. Satisfaction survey in general hospital personnel involved in blood transfusion: implementation of the ISO 9001: 2000 standard.

    Science.gov (United States)

    Chord-Auger, S; Tron de Bouchony, E; Moll, M C; Boudart, D; Folléa, G

    2004-10-01

    As part of its policy of constant quality improvement, Etablissement francais du sang (EFS) des pays de la Loire (Pays de la Loire Regional Blood Transfusion Centre) carried out a satisfaction survey among the hospital personnel involved in prescribing and using immunohaematological tests and labile blood products (LBP). The polling tool selected by agreement between the Saint Nazaire's hospital management and Quality Assurance (QA) Department was a questionnaire that permitted item rating and free commentary. It addressed the personnel's perception of the quality of erythrocyte immunohaematological (EIH) testing and of the products administered, as well as their perception of the quality of communications with the local EFS. The questionnaire was sent to 26 physicians and 32 senior nurses in 15 hospital departments. The reply rate was 60% and expressed an 85% overall satisfaction level. Dissatisfaction causes were more specifically analysed, the main one involving LBP distribution in emergency situations. A joint undertaking by the EFS and the hospital led to the implementation of corrective measures, including the writing and implementation of a common standard operating procedure for emergency transfusion management. The results obtained demonstrated the feasibility of this type of survey and the interest, to a blood transfusion centre and the hospital personnel involved in transfusion, of assessing their very own perception of service quality.

  9. Code development of the national hemovigilance system and expansion strategies for hospital blood banks

    Directory of Open Access Journals (Sweden)

    Kim Jeongeun

    2012-01-01

    Full Text Available Objectives : The aims of this study were to develop reportable event codes that are applicable to the national hemovigilance systems for hospital blood banks, and to present expansion strategies for the blood banks. Materials and Methods : The data were obtained from a literature review and expert consultation, followed by adding to and revising the established hemovigilance code system and guidelines to develop reportable event codes for hospital blood banks. The Medical Error Reporting System-Transfusion Medicine developed in the US and other codes of reportable events were added to the Korean version of the Biologic Products Deviation Report (BPDR developed by the Korean Red Cross Blood Safety Administration, then using these codes, mapping work was conducted. We deduced outcomes suitable for practice, referred to the results of the advisory councils, and conducted a survey with experts and blood banks practitioners. Results : We developed reportable event codes that were applicable to hospital blood banks and could cover blood safety - from blood product safety to blood transfusion safety - and also presented expansion strategies for hospital blood banks. Conclusion : It was necessary to add 10 major categories to the blood transfusion safety stage and 97 reportable event codes to the blood safety stage. Contextualized solutions were presented on 9 categories of expansion strategies of hemovigilance system for the hospital blood banks.

  10. Nanoscale drug delivery systems and the blood-brain barrier.

    Science.gov (United States)

    Alyautdin, Renad; Khalin, Igor; Nafeeza, Mohd Ismail; Haron, Muhammad Huzaimi; Kuznetsov, Dmitry

    2014-01-01

    The protective properties of the blood-brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs) in the brain's vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neurons have easier access to the central nervous system (CNS). As a consequence, CNS disorders, including degenerative diseases, can occur independently of an individual's age. Although the BBB is crucial in regulating the biochemical environment that is essential for maintaining neuronal integrity, it limits drug delivery to the CNS. This makes it difficult to deliver beneficial drugs across the BBB while preventing the passage of potential neurotoxins. Available options include transport of drugs across the ECs through traversing occludins and claudins in the tight junctions or by attaching drugs to one of the existing transport systems. Either way, access must specifically allow only the passage of a particular drug. In general, the BBB allows small molecules to enter the CNS; however, most drugs with the potential to treat neurological disorders other than infections have large structures. Several mechanisms, such as modifications of the built-in pumping-out system of drugs and utilization of nanocarriers and liposomes, are among the drug-delivery systems that have been tested; however, each has its limitations and constraints. This review comprehensively discusses the functional morphology of the BBB and the challenges that must be overcome by drug-delivery systems and elaborates on the potential targets, mechanisms, and formulations to improve drug delivery to the CNS.

  11. IAEA Safety Standards on Management Systems and Safety Culture

    Directory of Open Access Journals (Sweden)

    K.D. Persson

    2007-01-01

    Full Text Available The IAEA has developed a new set of Safety Standards for applying an integrated Management System for facilities and activities. The objective of the new Safety Standards is to define requirements and provide guidance for establishing, implementing, assessing and continually improving a Management System that integrates safety, health, environmental, security, quality and economic related elements to ensure that safety is properly taken into account in all the activities of an organization. With an integrated approach to management systems it is also necessary to include the aspect of culture, where the organizational culture and safety culture is seen as crucial elements of the successful implementation of this management system and the attainment of all the goals and particularly the safety goals of the organization. The IAEA has developed a set of services aimed at assisting it’s Member States in establishing, implementing, assessing and continually improving an integrated management system.

  12. IAEA Safety Standards on Management Systems and Safety Culture

    International Nuclear Information System (INIS)

    The IAEA has developed a new set of Safety Standard for applying an integrated Management System for facilities and activities. The objective of the new Safety Standards is to define requirements and provide guidance for establishing, implementing, assessing and continually improving a Management System that integrates safety, health, environmental, security, quality and economic related elements to ensure that safety is properly taken into account in all the activities of an organization. With an integrated approach to management system it is also necessary to include the aspect of culture, where the organizational culture and safety culture is seen as crucial elements of the successful implementation of this management system and the attainment of all the goals and particularly the safety goals of the organization. The IAEA has developed a set of service aimed at assisting it's Member States in establishing. Implementing, assessing and continually improving an integrated management system. (author)

  13. Evaluation of standard and advanced preprocessing methods for the univariate analysis of blood serum 1H-NMR spectra.

    Science.gov (United States)

    De Meyer, Tim; Sinnaeve, Davy; Van Gasse, Bjorn; Rietzschel, Ernst-R; De Buyzere, Marc L; Langlois, Michel R; Bekaert, Sofie; Martins, José C; Van Criekinge, Wim

    2010-10-01

    Proton nuclear magnetic resonance ((1)H-NMR)-based metabolomics enables the high-resolution and high-throughput assessment of a broad spectrum of metabolites in biofluids. Despite the straightforward character of the experimental methodology, the analysis of spectral profiles is rather complex, particularly due to the requirement of numerous data preprocessing steps. Here, we evaluate how several of the most common preprocessing procedures affect the subsequent univariate analyses of blood serum spectra, with a particular focus on how the standard methods perform compared to more advanced examples. Carr-Purcell-Meiboom-Gill 1D (1)H spectra were obtained for 240 serum samples from healthy subjects of the Asklepios study. We studied the impact of different preprocessing steps--integral (standard method) and probabilistic quotient normalization; no, equidistant (standard), and adaptive-intelligent binning; mean (standard) and maximum bin intensity data summation--on the resonance intensities of three different types of metabolites: triglycerides, glucose, and creatinine. The effects were evaluated by correlating the differently preprocessed NMR data with the independently measured metabolite concentrations. The analyses revealed that the standard methods performed inferiorly and that a combination of probabilistic quotient normalization after adaptive-intelligent binning and maximum intensity variable definition yielded the best overall results (triglycerides, R = 0.98; glucose, R = 0.76; creatinine, R = 0.70). Therefore, at least in the case of serum metabolomics, these or equivalent methods should be preferred above the standard preprocessing methods, particularly for univariate analyses. Additional optimization of the normalization procedure might further improve the analyses.

  14. Evolutionary genetics of the human Rh blood group system.

    Science.gov (United States)

    Perry, George H; Xue, Yali; Smith, Richard S; Meyer, Wynn K; Calışkan, Minal; Yanez-Cuna, Omar; Lee, Arthur S; Gutiérrez-Arcelus, María; Ober, Carole; Hollox, Edward J; Tyler-Smith, Chris; Lee, Charles

    2012-07-01

    The evolutionary history of variation in the human Rh blood group system, determined by variants in the RHD and RHCE genes, has long been an unresolved puzzle in human genetics. Prior to medical treatments and interventions developed in the last century, the D-positive (RhD positive) children of D-negative (RhD negative) women were at risk for hemolytic disease of the newborn, if the mother produced anti-D antibodies following sensitization to the blood of a previous D-positive child. Given the deleterious fitness consequences of this disease, the appreciable frequencies in European populations of the responsible RHD gene deletion variant (for example, 0.43 in our study) seem surprising. In this study, we used new molecular and genomic data generated from four HapMap population samples to test the idea that positive selection for an as-of-yet unknown fitness benefit of the RHD deletion may have offset the otherwise negative fitness effects of hemolytic disease of the newborn. We found no evidence that positive natural selection affected the frequency of the RHD deletion. Thus, the initial rise to intermediate frequency of the RHD deletion in European populations may simply be explained by genetic drift/founder effect, or by an older or more complex sweep that we are insufficiently powered to detect. However, our simulations recapitulate previous findings that selection on the RHD deletion is frequency dependent and weak or absent near 0.5. Therefore, once such a frequency was achieved, it could have been maintained by a relatively small amount of genetic drift. We unexpectedly observed evidence for positive selection on the C allele of RHCE in non-African populations (on chromosomes with intact copies of the RHD gene) in the form of an unusually high F( ST ) value and the high frequency of a single haplotype carrying the C allele. RhCE function is not well understood, but the C/c antigenic variant is clinically relevant and can result in hemolytic disease of the

  15. Standards in chestnut coppice system: cultural heritage or coltural requirement?

    Directory of Open Access Journals (Sweden)

    Manetti MC

    2012-12-01

    Full Text Available Standards in chestnut coppice system: cultural heritage or coltural requirement? This paper aims at evaluating the role of standards in chestnut coppices from a biological and functional perspective. In addition to a detailed analysis of Italian regulations on the issue, the technical definition of the term is analysed: (i as for the functional role of standards; (ii to assess whether the required functions are technically necessary and are being actually performed. In this contex, the results of an experimental trial are reported. The goal of the trial were to assess the shoots’ parameters, the stand productivity, the dynamics of canopy cover in coppices with or without standards. In 2001, at harvesting operations in a coppice aged 30 with standards managed by the local community, two experimental plots 2500 m2 each were established. The two theses being compared were: simple coppice and coppixce with standards (100 standards per hectare. The released standards were qualified immediately after final harvesting. Sprouting ability, growth pattern and stool vitality were surveyed in March 2004 (at age 2, in May 2008 (at age 6 and in April 2010 (at age 8. First results highlighted the evidence of statistically significant differences between the two thesis. The high number of standards effected negatively both vitality and growth pattern of the stools. Simple coppice recorded a lower shoot mortality, a higher diametrical growth and canopy cover degree as well; the heigth growth was, on the opposite, significantly lower. These results, although referred to a limited lifespan (1/3 of the rotation time and to one site only, underline productive, ecological and environmental benefits and as a consequence suggest the widening of the experimental network and the development of new, more relevant and consistent rules, making acceptable the simple coppice as a possible silvicultural choice to be applied to chestnut coppices.

  16. Development of standard ionization chamber counting system for activity measurements

    CERN Document Server

    Pyun, W B; Lee, H Y; Park, T S

    1998-01-01

    This study is to set up the activity measuring system using a 4 pi gamma ionization chamber as used mainly in national standards laboratories that are responsible for radionuclide metrology. The software for automatic control between the electrometer and personal computer is developed using Microsoft visual basic 4.0 and IEEE488 Interface. The reproducibility of this 4 pi gamma ionization chamber is about 0.02% and the background current is 0.054+-0.024 pA. this 4 pi gamma ionization chamber is calibrated by 6 standard gamma emitting radionuclides from KRISS. According to the result of this study, it is revealed that this 4 pi gamma ionization chamber counting system can be used as a secondary standard instrument for radioactivity measurement.

  17. The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system

    OpenAIRE

    Jitendra Singh Nigam; Savitri Singh; Viplesh Kaur; Sumit Giri; Ravi Prakash Kaushal

    2014-01-01

    Screening of blood and blood products is important to reduce the risk of transfusion transmitted infections (TTIs). The transfusion of unscreened or inadequately screened blood and blood products are the major source of TTIs. The aim of this paper is to find out the prevalence of TTIs in ABO blood groups and Rh type system. A total of 4128 blood donors were screened from January 2010 to April 2014. Serological tests were performed for hepatitis B surface antigen (HBsAg), anti hepatitis C viru...

  18. Non standard pallet series designing problem in ammunition supply system

    Institute of Scientific and Technical Information of China (English)

    Li Liangchun; Guo Min; Wang Hongwei

    2005-01-01

    According to the compound packing problem in ammunition supply system in our army, the non-standard pallet series design model is proposed, and the original problem that can be solved as a set cover problem with a nested bin-packing problem, is analyzed, then two heuristic algorithms are applied to solve the problem.

  19. A characteristics framework for Semantic Information Systems Standards

    NARCIS (Netherlands)

    Otto, B.; Folmer, E.J.A.; Ebner, V.

    2012-01-01

    Semantic Information Systems (IS) Standards play a critical role in the development of the networked economy. While their importance is undoubted by all stakeholders-such as businesses, policy makers, researchers, developers-the current state of research leaves a number of questions unaddressed. Ter

  20. 45 CFR 2543.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Standards for financial management systems. 2543... NATIONAL AND COMMUNITY SERVICE GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management §...

  1. 20 CFR 435.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Standards for financial management systems... REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT ORGANIZATIONS, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management §...

  2. 75 FR 35689 - System Personnel Training Reliability Standards

    Science.gov (United States)

    2010-06-23

    ... Reliability Standards for the Bulk-Power System, Order No. 693, Federal Register 72 FR 16,416 (Apr. 4, 2007... simulation technology such as a simulator, virtual technology, or other technology in their emergency... reliability coordinator area, (ii) continual training, and (iii) training staff identity and competency....

  3. 78 FR 44475 - Protection System Maintenance Reliability Standard

    Science.gov (United States)

    2013-07-24

    ... Standards for the Bulk Power System, Order No. 693, 72 FR 16,416 (April 4, 2007), FERC Stats. & Regs. ] 31... believes that vendor-issued firmware upgrades for microprocessor relays are common, and verification of... components within that segment. In addition, the maintenance history of the segment is to be reviewed...

  4. 75 FR 72664 - System Personnel Training Reliability Standards

    Science.gov (United States)

    2010-11-26

    ... objectives and training materials based on the task list performed by its System Operators each calendar year... Personnel Training Reliability Standards, 75 FR 35689 (June 17, 2010), FERC Stats. & Regs. ] 32,661 (2010... training, and (iii) training staff identity and competency. In the NOPR, the Commission sought comment...

  5. Beyond standardization : dynamic software infrastructures for systems biology

    NARCIS (Netherlands)

    Swertz, Morris A.; Jansen, Ritsert C.

    2007-01-01

    Progress in systems biology is seriously hindered by slow production of suitable software infrastructures. Biologists need infrastructure that easily connects to work that is done in other laboratories, for which standardization is helpful. However, the infrastructure must also accommodate the speci

  6. SIBAS: a blood bank information system and its 5-year implementation at Macau.

    Science.gov (United States)

    Li, Bing Nan; Chao, Sam; Chui Dong, Ming

    2007-05-01

    Automation systems and information technology can greatly help medical facilities to improve their working efficiency and optimize the whole workflow. This article surveys electronic information management in blood donation and transfusion service, and explores the rationale and archetype of blood bank information systems, then exemplifies a successful in-running system-Sistema Integrado de Bancos de Sangue (SIBAS), which is developed by the Institute of Systems and Computer Engineering of Macau (INESC-Macau) in cooperation with the Macau Blood Transfusion Center (CTS-Macau). Its implementation and the related lessons are briefly introduced too. In essence, this article is oriented to serve as a reference of contemporary blood bank information systems.

  7. Modelling of the Blood Coagulation Cascade in an In Vitro Flow System

    DEFF Research Database (Denmark)

    Andersen, Nina Marianne; Sørensen, Mads Peter; Efendiev, Messoud A.;

    2010-01-01

    We derive a mathematical model of a part of the blood coagulation cascade set up in a perfusion experiment. Our purpose is to simulate the influence of blood flow and diffusion on the blood coagulation pathway. The resulting model consists of a system of partial differential equations taking into...

  8. A STUDY OF DISTRIBUTION OF ABO AND RH BLOOD GROUPS SYSTEM AMONG BLOOD DONORS AT A TERTIARY CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar

    2015-02-01

    Full Text Available Up till now about 400red cells antigen have been identified. The majority are inherited by Mendelian fashion. The ABO and Rh blood group system was first to be identified and is most important for blood transfusion purposes. OBJECTIVE: This study was conducted to determine the frequency of ABO and Rhesus (Rh blood groups in a tertiary care teaching hospital in India. MATERIALS AND METHODS: A retrospective data based study was conducted at blood bank , Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh, India over a period of four years. RESULTS: Study includes a record of 3188 (28.54% voluntary and 7982 (71.46% replacement donors attending blood bank from February 2011 to January 2015. Out of 11170, 10723(95.998% were male and 447(4.002% female donors. The most common blood group was found to be B in 4013 (35.927% donors followed by O in 3462 (30.994% donors , an in 2516 (22.524% donors and AB in 1179 (10.555% donors. Out of these, 10659(95.425% donors were Rh - positive while 511 ( 4.575 % were Rh - negative.

  9. Clinical laboratory comparison of the 10-ml isolator blood culture system with BACTEC radiometric blood culture media.

    Science.gov (United States)

    Kellogg, J A; Manzella, J P; McConville, J H

    1984-10-01

    The efficiency of the 10-ml Isolator (E. I. du Pont de Nemours & Co., Inc.) for recovery of pathogens from blood was compared with that of BACTEC 6B and 7C media (Johnston Laboratories) by using 4,195 cultures from 1,662 patients. During the first phase of the study, BACTEC bottles were inoculated with 3 ml of blood; in the second phase, bottles were inoculated with 5 ml. The objectives were to compare results with similar blood volumes used for the detection of anaerobes as well as similar overall volumes and to determine the relative sensitivity of BACTEC media inoculated with the minimum and maximum volumes suggested by the manufacturer. From 180 patients, 391 significant isolates were recovered, 354 (91%) with the Isolator and 304 (78%) with the bottles. Isolators recovered 31 (15%) and 19 (18%) more pathogens overall than did the two-bottle system inoculated with 3 and 5 ml of blood, respectively, including 30 (36%) and 10 (34%) more Enterobacteriaceae. Recovery of anaerobes was greater in the BACTEC anaerobic medium, but only when its inoculum was increased to 5 ml. No significant differences existed between the two systems in pathogen detection times or detection of polymicrobic bacteremia. The Isolator contamination rate (8.3%) was approximately 4 times that of the bottles. The number of CFU of pathogen per milliliter of blood, blood volume sampled, and number of Isolators collected were more important than antimicrobial agent pretreatment in contributing to patient bacteremia of fungemia undetected by the Isolator. The Isolator appeared to be a practical alternative for recovery of aerobic and facultatively anaerobic pathogens from the blood. PMID:6386871

  10. Quantitation of postantibiotic effect by measuring CO2 generation of bacteria with the BACTEC blood culture system.

    OpenAIRE

    Gottfredsson, M; Erlendsdottir, H; Gudmundsson, S.

    1991-01-01

    The duration of the postantibiotic effect (PAE) determined by bacterial CO2 production measured by using the BACTEC NR 730 blood culture system was compared with PAEs determined by standard viability counting. PAEs for Staphylococcus aureus after exposure to dicloxacillin, vancomycin, rifampin, gentamicin, and ciprofloxacin and for Escherichia coli after exposure to ampicillin, gentamicin, and ciprofloxacin were quantitated by the two methods, and an excellent correlation (r = 0.93) was demon...

  11. Standard Guide for Specifying Thermal Performance of Geothermal Power Systems

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2000-01-01

    1.1 This guide covers power plant performance terms and criteria for use in evaluation and comparison of geothermal energy conversion and power generation systems. The special nature of these geothermal systems makes performance criteria commonly used to evaluate conventional fossil fuel-fired systems of limited value. This guide identifies the limitations of the less useful criteria and defines an equitable basis for measuring the quality of differing thermal cycles and plant equipment for geothermal resources. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

  12. Using ISO 25040 standard for evaluating electronic health record systems.

    Science.gov (United States)

    Oliveira, Marília; Novaes, Magdala; Vasconcelos, Alexandre

    2013-01-01

    Quality of electronic health record systems (EHR-S) is one of the key points in the discussion about the safe use of this kind of system. It stimulates creation of technical standards and certifications in order to establish the minimum requirements expected for these systems. [1] In other side, EHR-S suppliers need to invest in evaluation of their products to provide systems according to these requirements. This work presents a proposal of use ISO 25040 standard, which focuses on the evaluation of software products, for define a model of evaluation of EHR-S in relation to Brazilian Certification for Electronic Health Record Systems - SBIS-CFM Certification. Proposal instantiates the process described in ISO 25040 standard using the set of requirements that is scope of the Brazilian certification. As first results, this research has produced an evaluation model and a scale for classify an EHR-S about its compliance level in relation to certification. This work in progress is part for the acquisition of the degree of master in Computer Science at the Federal University of Pernambuco.

  13. Development of a blood extraction device for a miniature SMBG system

    Science.gov (United States)

    Matsuura, Yoshimitsu; Uenoya, Toshiyuki; Tsuchiya, Kazuyoshi; Uetsuji, Yasutomo; Nakamachi, Eiji

    2007-12-01

    In this study, a vacuum driven blood extraction device for the self-monitoring of blood glucose (SMBG) was newly developed. The health monitoring system (HMS) for SMBG consists of a blood extracting system and a drug delivery system (DDS). Our HMS extracts the blood through a micro-needle and measures the blood sugar level accurately. The main purpose of this work in HMS development are, 1) minimally invasive blood extraction, 2) a handy type automatic blood extraction, and 3) a continuous measurement of the blood sugar level. We adopted a vacuum driven type blood extraction mechanism. The vacuum driven blood extraction unit consists of a) a puncture part to open the vacuum part, b) an extraction part, and c) a measurement part. The puncture and extraction parts consist of a minimally invasive micro-needle, whose inner diameter is less than 100μm and made of titanium alloy, and a vacuum chamber, which is covered by a very thin membrane. A SMA spring and two bias springs are employed to penetrate the blood vessel through the skin with the micro-needle, and to execute the punctuation to slash the membrane in order to open the vacuum chamber. The blood is extracted into the vacuum chamber, seeps into the unwoven cloth according to the capillary principle, and is finally deposited on the blood sugar level sensor. Results show, our vacuum driven blood extraction device succeeded in extracting 12.7μl of human blood within 2 seconds. The blood sugar level was measured successfully by using a glucose enzyme sensor. Finally, the availability of our HMS device was confirmed.

  14. Mobile Personal Health System for Ambulatory Blood Pressure Monitoring

    Directory of Open Access Journals (Sweden)

    Luis J. Mena

    2013-01-01

    Full Text Available The ARVmobile v1.0 is a multiplatform mobile personal health monitor (PHM application for ambulatory blood pressure (ABP monitoring that has the potential to aid in the acquisition and analysis of detailed profile of ABP and heart rate (HR, improve the early detection and intervention of hypertension, and detect potential abnormal BP and HR levels for timely medical feedback. The PHM system consisted of ABP sensor to detect BP and HR signals and smartphone as receiver to collect the transmitted digital data and process them to provide immediate personalized information to the user. Android and Blackberry platforms were developed to detect and alert of potential abnormal values, offer friendly graphical user interface for elderly people, and provide feedback to professional healthcare providers via e-mail. ABP data were obtained from twenty-one healthy individuals (>51 years to test the utility of the PHM application. The ARVmobile v1.0 was able to reliably receive and process the ABP readings from the volunteers. The preliminary results demonstrate that the ARVmobile 1.0 application could be used to perform a detailed profile of ABP and HR in an ordinary daily life environment, bedsides of estimating potential diagnostic thresholds of abnormal BP variability measured as average real variability.

  15. Monitoring the effects of exposure to lead and cadmium in working and living environment through standard biochemical blood parameters and liver endonucleases activity

    Directory of Open Access Journals (Sweden)

    Nikolić Ružica S.

    2011-01-01

    Full Text Available Heavy metals as pollutants in the working and living environment are a serious health and environmental problem because they are toxic, non-biodegradable, accumulate in living systems and have a long half-life in soil. Sources of lead contamination are combustion products in the chemical industry and metallurgy, industrial waste water, landfills, traffic etc. Lead enters into the body via the food chain and drinking water. In the body lead is deposited in the liver, kidneys, brain and mineral tissues. Excretion of lead causes damage to the epithelial cells of certain organs. High level exposure to cadmium is usually the result of environmental pollution by human activities. Exposure to cadmium can lead to acute and chronic tissue damage of various organs, including liver and kidneys in humans and in animals. In this paper we analyzed the effects of lead and cadmium exposure, in working and living environment, on the model system of experimental animals, particularly the activity of certain liver enzymes, acid and alkaline DNase, and standard biochemical blood parameters. The study showed that lead and cadmium significantly affect the protein content, red blood cells, hemoglobin and hematocrit, and the activity of liver enzymes. This harmful effect of this toxic metal can be reduced by the supplements.

  16. Quality assurance: Importance of systems and standard operating procedures.

    Science.gov (United States)

    Manghani, Kishu

    2011-01-01

    It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality management. Quality control is focused on fulfilling quality requirements, whereas quality assurance is focused on providing confidence that quality requirements are fulfilled. The quality systems must be commensurate with the Company business objectives and business model. Top management commitment and its active involvement are critical in order to ensure at all times the adequacy, suitability, effectiveness and efficiency of the quality systems. Effective and efficient quality systems can promote timely registration of drugs by eliminating waste and the need for rework with overall financial and social benefits to the Company. PMID:21584180

  17. Development of an accurate 3D blood vessel searching system using NIR light

    Science.gov (United States)

    Mizuno, Yoshifumi; Katayama, Tsutao; Nakamachi, Eiji

    2010-02-01

    Health monitoring system (HMS) and drug delivery system (DDS) require accurate puncture by needle for automatic blood sampling. In this study, we develop a miniature and high accurate automatic 3D blood vessel searching system. The size of detecting system is 40x25x10 mm. Our searching system use Near-Infrared (NIR) LEDs, CMOS camera modules and image processing units. We employ the stereo method for searching system to determine 3D blood vessel location. Blood vessel visualization system adopts hemoglobin's absorption characterization of NIR light. NIR LED is set behind the finger and it irradiates Near Infrared light for the finger. CMOS camera modules are set in front of the finger and it captures clear blood vessel images. Two dimensional location of the blood vessel is detected by luminance distribution of the image and its depth is calculated by the stereo method. 3D blood vessel location is automatically detected by our image processing system. To examine the accuracy of our detecting system, we carried out experiments using finger phantoms with blood vessel diameters, 0.5, 0.75, 1.0mm, at the depths, 0.5 ~ 2.0 mm, under the artificial tissue surface. Experimental results of depth obtained by our detecting system showed good agreements with given depths, and the availability of this system is confirmed.

  18. Standardized accuracy assessment of the calypso wireless transponder tracking system

    Science.gov (United States)

    Franz, A. M.; Schmitt, D.; Seitel, A.; Chatrasingh, M.; Echner, G.; Oelfke, U.; Nill, S.; Birkfellner, W.; Maier-Hein, L.

    2014-11-01

    Electromagnetic (EM) tracking allows localization of small EM sensors in a magnetic field of known geometry without line-of-sight. However, this technique requires a cable connection to the tracked object. A wireless alternative based on magnetic fields, referred to as transponder tracking, has been proposed by several authors. Although most of the transponder tracking systems are still in an early stage of development and not ready for clinical use yet, Varian Medical Systems Inc. (Palo Alto, California, USA) presented the Calypso system for tumor tracking in radiation therapy which includes transponder technology. But it has not been used for computer-assisted interventions (CAI) in general or been assessed for accuracy in a standardized manner, so far. In this study, we apply a standardized assessment protocol presented by Hummel et al (2005 Med. Phys. 32 2371-9) to the Calypso system for the first time. The results show that transponder tracking with the Calypso system provides a precision and accuracy below 1 mm in ideal clinical environments, which is comparable with other EM tracking systems. Similar to other systems the tracking accuracy was affected by metallic distortion, which led to errors of up to 3.2 mm. The potential of the wireless transponder tracking technology for use in many future CAI applications can be regarded as extremely high.

  19. Performance evaluation of continuous blood sampling system for PET study. Comparison of three detector-systems

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Keiichi; Shinoda, Masaki; Sakamoto, Setsu; Senda, Michio [Inst. of Biomedical Research and Innovation, Kobe (Japan); Yamamoto, Seiichi [Kobe City Coll. of Technology (Japan); Tarutani, Kazumasa; Minato, Kotaro [Nara Inst. of Science and Technology, Ikoma (Japan). Graduate School of Information Science

    2002-11-01

    To measure cerebral blood flow with {sup 15}O PET, it is necessary to measure the time course of arterial blood radioactivity. We examined the performance of three different types of continuous blood sampling system. Three kinds of continuous blood sampling system were used: a plastic scintillator-based beta detector (conventional beta detector (BETA)), a bismuth germinate (BGO)-based coincidence gamma detector (Pico-count flow-through detector (COINC)) and a Phoswich detector (PD) composed by a combination of plastic scintillator and BGO scintillator. Performance of these systems was evaluated for absolute sensitivity, count rate characteristic, sensitivity to background gamnra photons, and reproducibility for nylon tube geometry. The absolute sensitivity of the PD was 0.21 cps/Bq for {sup 68}Ga positrons at the center of the detector. This was approximately three times higher than BETA, two times higher than COINC. The value measured with BETA was stable, even when background radioactivity was increased. The count rate characteristic of the PD and COINC was linear up to 8 kcps. The reproducibility of sensitivity for nylon tube geometry of COINC was the smallest (coefficient of variation (C.V.)=1.00%) among the three. PD was the weights the least (3.5 kg) among the three, which is convenient for clinical use. Each detector has unique characteristics derived from its own structure. Although the performance of all three detectors meets clinical requirement, PD had the highest physical performance. (author)

  20. Performance evaluation of continuous blood sampling system for PET study. Comparison of three detector-systems

    CERN Document Server

    Matsumoto, K; Sakamoto, S; Senda, M; Yamamoto, S; Tarutani, K; Minato, K

    2002-01-01

    To measure cerebral blood flow with sup 1 sup 5 O PET, it is necessary to measure the time course of arterial blood radioactivity. We examined the performance of three different types of continuous blood sampling system. Three kinds of continuous blood sampling system were used: a plastic scintillator-based beta detector (conventional beta detector (BETA)), a bismuth germinate (BGO)-based coincidence gamma detector (Pico-count flow-through detector (COINC)) and a Phoswich detector (PD) composed by a combination of plastic scintillator and BGO scintillator. Performance of these systems was evaluated for absolute sensitivity, count rate characteristic, sensitivity to background gamnra photons, and reproducibility for nylon tube geometry. The absolute sensitivity of the PD was 0.21 cps/Bq for sup 6 sup 8 Ga positrons at the center of the detector. This was approximately three times higher than BETA, two times higher than COINC. The value measured with BETA was stable, even when background radioactivity was incre...

  1. A constructive critique of the three standard systems

    International Nuclear Information System (INIS)

    It has become conventional to say that our knowledge of fundamental physical law is summarized in a Standard Model. But this convention lumps together two quite different conceptual structures, and leaves out another. I think it is more accurate and informative to say that our current, working description of fundamental physics is based on three standard conceptual systems. These systems are very different; so different that it is not inappropriate to call them the Good, the Bad, and the Ugly. They concern, respectively, the coupling of vector gauge particles, gravitons, and Higgs particles. It is quite a remarkable fact, in itself, that every nonlinear interaction we need to summarize our present knowledge of the basic (i.e., irreducible) laws of physics involves one or another of these particles. (author)

  2. A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans.

    Science.gov (United States)

    Schaller, R; Feichtner, F; Köhler, H; Bodenlenz, M; Plank, J; Wutte, A; Mader, J K; Ellmerer, M; Hellmich, R; Wedig, H; Hainisch, R; Pieber, T R; Schaupp, L

    2009-03-15

    Intensive insulin therapy reduces mortality and morbidity in critically ill patients but imposes great demands on medical staff who must take frequent blood samples for the determination of glucose levels. A solution to this resourcing problem would be provided by an automated blood monitoring system. The aim of the present clinical study was to evaluate such a system comprising an automatic blood sampling unit linked to a glucose biosensor. Our approach was to determine the correlation and system error of the sampling unit alone and of the combined system with respect to reference levels over 12h in humans. Two venous cannulae were inserted to connect the automatic and reference systems to the subjects. Blood samples were taken at 15 and 30 min intervals. The median Pearson coefficient of correlation between manually and automatically withdrawn blood samples was 0.982 for the sampling unit alone and 0.950 for the complete system. The biosensor had a linear range up to 20 mmoll(-1) and a 95% response time of Titration Error Grid analysis suggested an acceptable treatment in 99.56% of cases. Implementation of a "Keep Vein Open" saline infusion into the automated blood sampling system reduced blood withdrawal failures through occluded catheters fourfold. In summary, automated blood sampling from a peripheral vein coupled with automatic glucose determination is a promising alternative to frequent manual blood sampling. PMID:19135351

  3. Standard data systems architecture for the Space Station

    Science.gov (United States)

    Greenberg, E.; Hooke, A. J.; Pomphrey, R. B.; Smith, J. F.

    1986-01-01

    Attention is given to an end-to-end Space Station Data System (SSDS) architecture which is based on internationally-recommended standards developed by the Consultative Committee for Space Data Systems (CCSDS). The proposed system uses simple modular building blocks that are recursively replicated and linked to construct essentially any desired data system configuration. The SSDS concept provides for a user-transparent data transport system which is entirely independent of the characteristics of the user data being transported, and in addition, has the flexibility to accommodate mission-induced changes in data traffic. SSDS physical elements include the following: (1) on-orbit local area networks, (2) space-to-ground, ground-to-space, and space-to-space data links, and (3) ground mission support facilities containing telemetry and telecommand data handling termini and preprocessing services.

  4. Duffy Blood Group System and the malaria adaptation process in humans

    OpenAIRE

    Gledson Barbosa de Carvalho; Glauber Barbosa de Carvalho

    2011-01-01

    Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine due to their association with the invasion of red blood cells by the parasite Plasmodium vivax. For invasions to occur an interaction between the parasites and antigens of the Duffy Blood Group System is necessary. In Caucasians six antigens a...

  5. Standard hydrogen monitoring system-B operation and maintenance manual

    International Nuclear Information System (INIS)

    The purpose of this document is to provide information for the operation and maintenance of the Standards Hydrogen Monitoring System-B (SHMS-B) used in the 200E and 200W area tank farms on the Hanford site. This provides information specific to the mechanical operation of the system and is not intended to take the place of a Plant Operating Procedure. The primary function of the SHMS-B is to monitor specifically for hydrogen in the waste tank vapor space which may also contain unknown quantities of other gaseous constituents

  6. Improving collaboration by standardization efforts in systems biology.

    Science.gov (United States)

    Dräger, Andreas; Palsson, Bernhard Ø

    2014-01-01

    Collaborative genome-scale reconstruction endeavors of metabolic networks would not be possible without a common, standardized formal representation of these systems. The ability to precisely define biological building blocks together with their dynamic behavior has even been considered a prerequisite for upcoming synthetic biology approaches. Driven by the requirements of such ambitious research goals, standardization itself has become an active field of research on nearly all levels of granularity in biology. In addition to the originally envisaged exchange of computational models and tool interoperability, new standards have been suggested for an unambiguous graphical display of biological phenomena, to annotate, archive, as well as to rank models, and to describe execution and the outcomes of simulation experiments. The spectrum now even covers the interaction of entire neurons in the brain, three-dimensional motions, and the description of pharmacometric studies. Thereby, the mathematical description of systems and approaches for their (repeated) simulation are clearly separated from each other and also from their graphical representation. Minimum information definitions constitute guidelines and common operation protocols in order to ensure reproducibility of findings and a unified knowledge representation. Central database infrastructures have been established that provide the scientific community with persistent links from model annotations to online resources. A rich variety of open-source software tools thrives for all data formats, often supporting a multitude of programing languages. Regular meetings and workshops of developers and users lead to continuous improvement and ongoing development of these standardization efforts. This article gives a brief overview about the current state of the growing number of operation protocols, mark-up languages, graphical descriptions, and fundamental software support with relevance to systems biology. PMID:25538939

  7. Improving collaboration by standardization efforts in systems biology

    Directory of Open Access Journals (Sweden)

    Andreas eDräger

    2014-12-01

    Full Text Available Collaborative genome-scale reconstruction endeavors of metabolic networks would not be possible without a common, standardized formal representation of these systems. The ability to precisely define biological building blocks together with their dynamic behavior has even been considered a prerequisite for upcoming synthetic biology approaches.Driven by the requirements of such ambitious research goals, standardization itself has become an active field of research on nearly all levels of granularity in biology.In addition to the originally envisaged exchange of computational models and tool interoperability, new standards have been suggested for an unambiguous graphical display of biological phenomena, to annotate, archive, as well as to rank models, and to describe execution and the outcomes of simulation experiments. The spectrum now even covers the interaction of entire neurons in the brain, three-dimensional motions, and the description of pharmacometric studies.Thereby, the mathematical description of systems and approaches for their (repeated simulation are clearly separated from each other and also from their graphical representation. Minimum information definitions constitute guidelines and common operation protocols in order to ensure reproducibility of findings and a unified knowledge representation.Central database infrastructures have been established that provide the scientific community with persistent links from model annotations to on-line resources. A rich variety of open-source software tools thrives for all data formats, often supporting a multitude of programming languages. Regular meetings and workshops of developers and users lead to continuous improvement and ongoing development of these standardization efforts.This article gives a brief overview about the current state of the growing number of operation protocols, markup languages, graphical descriptions, and fundamental software support with relevance to systems biology.

  8. Interval standard neural network models for nonlinear systems

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A neural-network-based robust control design is suggested for control of a class of nonlinear systems. The design approach employs a neural network, whose activation functions satisfy the sector conditions, to approximate the nonlinear system. To improve the approximation performance and to account for the parameter perturbations during operation, a novel neural network model termed standard neural network model (SNNM) is proposed. If the uncertainty is bounded, the SNNM is called an interval SNNM (ISNNM). A state-feedback control law is designed for the nonlinear system modelled by an ISNNM such that the closed-loop system is globally, robustly, and asymptotically stable. The control design equations are shown to be a set of linear matrix inequalities (LMIs) that can be easily solved by available convex optimization algorithms. An example is given to illustrate the control design procedure, and the performance of the proposed approach is compared with that of a related method reported in literature.

  9. Standard Hydrogen Monitoring System-D operation and maintenance manual

    International Nuclear Information System (INIS)

    The purpose of this document is to provide information for the operation and maintenance of the Standard Hydrogen Monitoring System-D (SHMS-D) used in the 200E and 200W area tank farms on the Hanford Site. This provides information specific to the mechanical operation of the system and is not intended to take the place of a Plant Operating Procedure. However, it does provide more information on the system than a Plant Operating Procedure. The intent here is that the system is started up by a technician or engineer who has completed tank farms training course No. 351405, and then the only actions performed by Operations will be routine log taking. If any problems not addressed by the operating procedure are encountered with the unit, engineering should be contacted

  10. A Standardized Evaluation System for Decadal Climate Prediction

    Science.gov (United States)

    Kadow, C.; Cubasch, U.

    2012-12-01

    The evaluation of decadal prediction systems is a scientific challenge as well as a technical challenge in the climate research. The major project MiKlip (www.fona-miklip.de) for medium-term climate prediction funded by the Federal Ministry of Education and Research in Germany (BMBF) has the aim to create a model system that can provide reliable decadal forecasts on climate and weather. The model system to be developed will be novel in several aspects, with great challenges for the methodology development. This concerns especially the determination of the initial conditions, the inclusion into the model of processes relevant to decadal predictions, the increase of the spatial resolution through regionalisation, the improvement or adjustment of statistical post-processing, and finally the synthesis and validation of the entire model system. Therefore, a standardized evaluation system will be part of the MiKlip system to validate it - developed by the project 'Integrated data and evaluation system for decadal scale prediction' (INTEGRATION). The presentation gives an overview of the different linkages of such a project, shows the different development stages and gives an outlook for users and possible end users in climate service. The technical interface combines all projects inside of MiKlip and invites them to participate in a common evaluation system. The system design and the validation strategy from a standalone tool in the beginning to a user friendly web based system using GRID technologies to an integrated part of the operational MiKlip system for industry and society will give the opportunity to enhance the MiKlip strategy. First results of different possibilities of such a system will be shown to present the scientific background through Taylor diagrams, ensemble skill scores and e.g. climatological means to show the usability and possibilities of MiKlip and the INTEGRATION project.

  11. [ABO system blood group ratios in patients with neuroinfections].

    Science.gov (United States)

    Rudometov, Iu P; Umanskiĭ, K G; Ashmarina, E E; Andreeva, L S

    1981-01-01

    The distribution of the ABO blood groups in 2009 patients including 1441 ones suffering from etiologically diverse neuroinfections was studied. Certain correlations between the nosological forms and groups of the diseases on the one hand, and the blood factors on the other are demonstrated. The data obtained point to a certain role of hereditary predisposition in the genesis of the neuroinfections. This predisposition predetermines the risk of the illnesses and the gravity of their course, the fact, which is of a practical importance for the clinician.

  12. Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity.

    Science.gov (United States)

    Kuo, Terry B J; Chern, Chang-Ming; Yang, Cheryl C H; Hsu, Hung-Yi; Wong, Wen-Jang; Sheng, Wen-Yung; Hu, Han-Hwa

    2003-01-01

    To explore the mechanisms underlying the phase lag between oscillations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV), ABP and CBFV signals were recorded noninvasively from normal volunteers who lay quietly in a supine position. Mean ABP (MAP) and CBFV (MFV) were calculated beat-to-beat by means of integration. Cerebral vascular resistance (CVR) was calculated by dividing MAP with MFV. Frequency domain analysis of MAP, MFV and CVR signals revealed very-low frequency (VLF, 0.016-0.04 Hz), low-frequency (LF, 0.04-0.15 Hz), and high-frequency (HF, 0.15-0.4 Hz) components. The transfer phase of MAP-CVR coupling in the LF and HF range was frequency-dependent, which is equivalent to a time delay of 2 s. However, the transfer phase differed in the CVR-MFV coupling in that the phase was distributed around 180 degrees across the LF and HF ranges. Cross-correlation analysis revealed a positive relationship between MAP-CVR coupling, with MAP leading by 2 s, and a negative relationship between CVR-MFV coupling, with CVR leading by 0.3 s. We concluded that the phase lag between oscillations in ABP and CBFV was chiefly contributed to by the starting latency of cerebral autoregulation (i.e. cerebral vasomotion, revealed by MAP-CVR coupling). Moreover, the negative correlation of the CVR-MFV coupling could offer a different explanation for the physiologic significance of the phase lead of CBFV-ABP oscillations.

  13. Modified mouse peripheral blood lymphocyte culture system for cytogenetic analysis

    International Nuclear Information System (INIS)

    A detailed methodology is presented for culturing mouse peripheral blood lymphocytes isolated on density gradients and stimulated to divide using either phytohemagglutinin, concanavalin A, or lipopolysaccharide. The techniques described yield more than sufficient numbers of mitotic cells for analyzing sister chromatid exchange, chromosome, aberrations, and micronuclei following in vitro or in vivo exposure to chemicals or radiation

  14. ACTIVE TARGETING WITH PARTICULATE CARRIER SYSTEMS IN THE BLOOD COMPARTMENT

    NARCIS (Netherlands)

    CROMMELIN, DJA; SCHERPHOF, G; STORM, G

    1995-01-01

    This review deals with active targeting of particulate drug carriers through (1) physico-chemical (e.g., complex formation between a homing device and a surface exposed molecule at the target site) and (2) physical means, Target sites discussed are restricted to those in the blood circulation. Targe

  15. Electronic health record standards, coding systems, frameworks, and infrastructures

    CERN Document Server

    Sinha, Pradeep K; Bendale, Prashant; Mantri, Manisha; Dande, Atreya

    2013-01-01

    Discover How Electronic Health Records Are Built to Drive the Next Generation of Healthcare Delivery The increased role of IT in the healthcare sector has led to the coining of a new phrase ""health informatics,"" which deals with the use of IT for better healthcare services. Health informatics applications often involve maintaining the health records of individuals, in digital form, which is referred to as an Electronic Health Record (EHR). Building and implementing an EHR infrastructure requires an understanding of healthcare standards, coding systems, and frameworks. This book provides an

  16. Electronic circuits, systems and standards the best of EDN

    CERN Document Server

    Hickman, Ian

    2013-01-01

    Electronic Circuits, Systems and Standards: The Best of EDN is a collection of 66 EDN articles. The topics covered in this collection are diverse but all are relevant to controlled circulation electronics. The coverage of the text includes topics about software and algorithms, such as simple random number algorithm; simple log algorithm; and efficient algorithm for repeated FFTs. The book also tackles measurement related topics, including test for identifying a Gaussian noise source; enhancing product reliability; and amplitude-locked loop speeds filter test. The text will be useful to student

  17. Detection of non-standard atmospheric effects in FSO systems

    Science.gov (United States)

    Wilfert, Otakar; Poliak, Juraj; Barcík, Peter; Arce-Diego, José L.; Fanjul-Vélez, Félix; Salas-García, Irene; Ortega Quijano, Noé

    2013-09-01

    Modern free-space optical (FSO) communication systems in many aspects overcome wire or radio communications. They offer a license-free operation and a large bandwidth. Operation of outdoor FSO links struggles with many atmospheric phenomena that deteriorate phase and amplitude of the transmitted optical beam. Thanks to the recent advancing development, these effects are more or less well understood and described. Goal driven research increased the link availability. Besides increasing the availability of data links it is necessary to focus on the accuracy and reliability of testing optical links. Research of the data optical links is focused on the transmission of a large amount of data whereas the testing FSO link is designed to achieve maximal resolution and sensitivity thus improving accuracy and repeatability of the atmospheric effects measurement. Given the fact that testing links are located in the measured media, they are themselves influenced by it. Phenomena such as the condensation on transceiver windows (rain, frost) and the deviation of the optical beam path caused by the wind are referred to as non-standard effects. Non-standard effects never occur independently; therefore we must always verify the cross-sensitivity of the testing link. In the paper we respond to an increasing number of articles dealing with influence of the atmosphere on the link but ignoring the cross-sensitivity of the testing link on other variables than tested. In conclusion, we carry out qualitative and quantitative analysis of self-identified non-standard effects.

  18. Quality assurance: Importance of systems and standard operating procedures

    Directory of Open Access Journals (Sweden)

    Kishu Manghani

    2011-01-01

    Full Text Available It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality management. Quality control is focused on fulfilling quality requirements, whereas quality assurance is focused on providing confidence that quality requirements are fulfilled. The quality systems must be commensurate with the Company business objectives and business model. Top management commitment and its active involvement are critical in order to ensure at all times the adequacy, suitability, effectiveness and efficiency of the quality systems. Effective and efficient quality systems can promote timely registration of drugs by eliminating waste and the need for rework with overall financial and social benefits to the Company.

  19. STANDARDIZATION OF GLYCOHEMOGLOBIN RESULTS AND REFERENCE VALUES IN WHOLE-BLOOD STUDIED IN 103 LABORATORIES USING 20 METHODS

    NARCIS (Netherlands)

    WEYKAMP, CW; PENDERS, TJ; MUSKIET, FAJ; VANDERSLIK, W

    1995-01-01

    We investigated the effect of calibration with lyophilized calibrators on whole-blood glycohemoglobin (glyHb) results. One hundred three laboratories, using 20 different methods, determined glyHb in two lyophilized calibrators and two whole-blood samples. For whole-blood samples with low (5%) and hi

  20. Analytical Performance Requirements for Systems for Self-Monitoring of Blood Glucose With Focus on System Accuracy: Relevant Differences Among ISO 15197:2003, ISO 15197:2013, and Current FDA Recommendations

    OpenAIRE

    Freckmann, Guido; Schmid, Christina; Baumstark, Annette; Rutschmann, Malte; Haug, Cornelia; Heinemann, Lutz

    2015-01-01

    In the European Union (EU), the ISO (International Organization for Standardization) 15197 standard is applicable for the evaluation of systems for self-monitoring of blood glucose (SMBG) before the market approval. In 2013, a revised version of this standard was published. Relevant revisions in the analytical performance requirements are the inclusion of the evaluation of influence quantities, for example, hematocrit, and some changes in the testing procedures for measurement precision and s...

  1. Quantification of Saquinavir from Lysates of Peripheral Blood Mononuclear Cells Using Microarrays and Standard MALDI-TOF-MS

    Science.gov (United States)

    Pabst, Martin; Fagerer, Stephan Rupert; Köhling, Rudolf; Eyer, Klaus; Krismer, Jasmin; Jefimovs, Konstantins; Ibáñez, Alfredo Jesus; Zenobi, Renato

    2014-06-01

    Drug monitoring is usually performed by liquid chromatography coupled with optical detection or electrospray ionization mass spectrometry. More recently, matrix-assisted laser desorption/ionization (MALDI) in combination with triple quadrupole or Fourier-transform (FT) mass analyzers has also been reported to allow accurate quantification. Here, we present a strategy that employs standard MALDI time-of-flight (TOF) mass spectrometry (MS) for the sensitive and accurate quantification of saquinavir from an extract of blood peripheral mononuclear cells. Unambiguous identification of saquinavir in the mass spectra was possible because of using internal mass calibration and by an overall low chemical noise in the low mass range. Exact mass determination of the constant background peaks of the cell extract, which were used for recalibration, was performed by an initial MALDI-FT-MS analysis. Fast and multiplexed sample analysis was enabled by microarray technology, which provided 10 replicates in the lower nL range for each sample in parallel lanes on a chip. In order to validate the method, we employed various statistical tests, such as confidence intervals for linear regressions, three quality control samples, and inverse confidence limits of the estimated concentration ratios.

  2. Relating Standardized Visual Perception Measures to Simulator Visual System Performance

    Science.gov (United States)

    Kaiser, Mary K.; Sweet, Barbara T.

    2013-01-01

    Human vision is quantified through the use of standardized clinical vision measurements. These measurements typically include visual acuity (near and far), contrast sensitivity, color vision, stereopsis (a.k.a. stereo acuity), and visual field periphery. Simulator visual system performance is specified in terms such as brightness, contrast, color depth, color gamut, gamma, resolution, and field-of-view. How do these simulator performance characteristics relate to the perceptual experience of the pilot in the simulator? In this paper, visual acuity and contrast sensitivity will be related to simulator visual system resolution, contrast, and dynamic range; similarly, color vision will be related to color depth/color gamut. Finally, we will consider how some characteristics of human vision not typically included in current clinical assessments could be used to better inform simulator requirements (e.g., relating dynamic characteristics of human vision to update rate and other temporal display characteristics).

  3. An Orbiting Standards Platform for communication satellite system RF measurements

    Science.gov (United States)

    Wallace, R. G.; Woodruff, J. J.

    1978-01-01

    The Orbiting Standards Platform (OSP) is a proposed satellite dedicated to performing RF measurements on space communications systems. It would consist of a quasi-geostationary spacecraft containing an ensemble of calibrated RF sources and field strength meters operating in several microwave bands, and would be capable of accurately and conveniently measuring critical earth station and satellite RF performance parameters, such as EIRP, gain, figure of merit (G/T), crosspolarization, beamwidth, and sidelobe levels. The feasibility and utility of the OSP concept has been under joint study by NASA, NBS, Comsat and NTIA. A survey of potential OSP users was conducted by NTIA as part of this effort. The response to this survey, along with certain trends in satellite communications system design, indicates a growing need for such a measurement service.

  4. Standard practice for verification and classification of extensometer systems

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 This practice covers procedures for the verification and classification of extensometer systems, but it is not intended to be a complete purchase specification. The practice is applicable only to instruments that indicate or record values that are proportional to changes in length corresponding to either tensile or compressive strain. Extensometer systems are classified on the basis of the magnitude of their errors. 1.2 Because strain is a dimensionless quantity, this document can be used for extensometers based on either SI or US customary units of displacement. Note 1—Bonded resistance strain gauges directly bonded to a specimen cannot be calibrated or verified with the apparatus described in this practice for the verification of extensometers having definite gauge points. (See procedures as described in Test Methods E251.) 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish app...

  5. Handbook of SOFC system in buildings. Legislation, standards and requirements

    Energy Technology Data Exchange (ETDEWEB)

    Klobut, K.; Vesanen, T.; Pykaelae, M.-L.; Sipilae, K.; Kiviaho, J.; Rosenberg, R.

    2009-02-15

    This publication is aimed at supporting the installation and exploitation of 50 kW SOFC in an office building. In this context, the standardisation situation has been scanned worldwide. Requirements concerning connection of the SOFC system to the public networks have been explored and solutions consulted with authorities and owners of the local natural gas, heating and electricity networks. Installed fuel cell systems must be CE marked and comply with a set of European Union directives. The group of standards related to stationary systems produced by the IEC TC 105 committee is the most important regulatory base for application preparation. A fuel cell power system and associated equipment, components, and controls shall be sited and installed in accordance with the manufacturer's instructions. A written fire prevention and emergency plan shall be provided as required by and in accordance with national standards. The room or area where the fuel cell power system is installed shall have a hydrogen detector. A new proposal has been developed, which combines a fuel cell system with the otherwise typical district heating connection scheme in Finland. Materials in connection with this must be carefully selected in the primary and secondary side to qualify for the whole life cycle. It must be possible to measure energy consumption in both directions (buy/sell mode). There are important requirements concerning electric energy-generating units. All exposed conductive parts of the electric power system shall be connected to the main earthing terminal or bar. If the neutral conductor exists it shall be connected at the network supply end to the main earthing terminal. The output filters of an interconnection device may not cause resonances with the rest of the electric grid. The interference with the grid operation is not allowed by any other reactive components that may cause changes in the operating parameters of the filters. The systems equipped with an inverter may

  6. Standard guide for acoustic emission system performance verification

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 System performance verification methods launch stress waves into the examination article on which the sensor is mounted. The resulting stress wave travels in the examination article and is detected by the sensor(s) in a manner similar to acoustic emission. 1.2 This guide describes methods which can be used to verify the response of an Acoustic Emission system including sensors, couplant, sensor mounting devices, cables and system electronic components. 1.3 Acoustic emission system performance characteristics, which may be evaluated using this document, include some waveform parameters, and source location accuracy. 1.4 Performance verification is usually conducted prior to beginning the examination. 1.5 Performance verification can be conducted during the examination if there is any suspicion that the system performance may have changed. 1.6 Performance verification may be conducted after the examination has been completed. 1.7 The values stated in SI units are to be regarded as standard. No other u...

  7. A Digital Method for the Detection of Blood Flow Direction in Ultrasonic Doppler Systems

    OpenAIRE

    P. Acevedo–Contla.; M. Barragán–Ocampo.; E. Moreno–Hernández.; F. García–Nocetti.; M. Fuentes–Cruz.; A. Sotomayor–Ortega

    2010-01-01

    Doppler ultrasound systems are widely used to study blood flow and diagnosis of vascular diseases. An important characteristic of these systems is the ability to detect the direction of the blood flow. Most Doppler ultrasound systems apply a quadrature demodulation technique on the ultrasonic transducer output signal. Therefore additional treatment is necessary to separate forward and reverse flow signals. This work presents a digital method to convert signals in quadrature into directional s...

  8. Where to Donate Blood

    Science.gov (United States)

    ... zip code using the Blood Bank Locator below: Blood Bank Locator City: State/Province: ZIP Code: Country: Show ... safety and care. The Association sets standards for blood banks and transfusion services, and accredits member blood banks ...

  9. High blood pressure

    Science.gov (United States)

    ... you are at risk for: Bleeding from the aorta, the large blood vessel that supplies blood to ... tests Blood pressure check Blood pressure References American Diabetes Association. Standards of medical care in diabetes-2015 ...

  10. Types of Blood Donations

    Science.gov (United States)

    ... Double Red Cell Plasma Platelets Red Cells What blood donation type is best for me? **If you do not ... blood type, a whole blood donation is recommended** Blood Donation Types: Volunteer Donations The standard or most common type ...

  11. The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system

    Directory of Open Access Journals (Sweden)

    Jitendra Singh Nigam

    2014-12-01

    Full Text Available Screening of blood and blood products is important to reduce the risk of transfusion transmitted infections (TTIs. The transfusion of unscreened or inadequately screened blood and blood products are the major source of TTIs. The aim of this paper is to find out the prevalence of TTIs in ABO blood groups and Rh type system. A total of 4128 blood donors were screened from January 2010 to April 2014. Serological tests were performed for hepatitis B surface antigen (HBsAg, anti hepatitis C virus (Anti-HCV, anti HIV-1 and 2, venereal disease research laboratory test (VDRL and malaria parasite (MP antigen. In seroreactive donors, HBsAg, Anti-HCV, VDRL, MP antigen and anti HIV were positive in 40 cases, 26 cases, 19 cases, 6 cases and 2 cases, respectively. Highest percentage of HBsAg, Anti HCV, VDRL, MP antigen and anti HIV was observed in blood group A negative (2/50, O negative (1/66, B negative (1/91, AB positive (2/377 blood group respectively. In the present study, the total number of Rh-negative donors is lower when compared to Rh-positive blood donors, but Rh-negative blood donors show higher percentages of seroreactivity for TTIs. Larger scale studies at molecular level are required to improve the knowledge of this aspect.

  12. An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study

    NARCIS (Netherlands)

    S.J. Thorpe; B. Fox; A.B. Heath; M. Scott; M. de Haas; S. Kochman; A. Padilla

    2006-01-01

    Background and Objectives The aim of this study was to evaluate a lyophilized monoclonal immunoglobulin M (IgM) anti-D preparation for use as an International Standard to specify a recommended minimum acceptable potency of anti-D blood-grouping reagents. Materials and Methods The candidate Internati

  13. Continuous blood pressure monitoring in cirrhosis. Relations to splanchnic and systemic haemodynamics

    DEFF Research Database (Denmark)

    Møller, Søren; Christensen, E; Henriksen, Jens Henrik

    1997-01-01

    blood pressure and related to the results of an invasive haemodynamic investigation, including measurements of intra-arterial blood pressure (9.00-11.00 h) in 37 patients with cirrhosis. RESULTS: The 24-h blood pressures were significantly lower and the heart rate was significantly higher in patients......BACKGROUND/AIMS: Low arterial blood pressure is recognised as a distinctive factor in the hyperdynamic circulation in cirrhosis. 24-hour monitoring of the blood pressure and heart rate has recently revealed a reduced circadian variation with relation to liver function. However, associations...... with other clinical and haemodynamic characteristics have not been investigated and the aim of the present study was to identify splanchnic and systemic determinants of the 24-h blood pressure and heart rate in cirrhosis. METHODS: The variables were measured by an automatic ambulant device for monitoring...

  14. Integration of virtualized worker nodes in standard batch systems

    Energy Technology Data Exchange (ETDEWEB)

    Buege, Volker; Kunze, Marcel; Oberst, Oliver; Quast, Guenter; Scheurer, Armin [Karlsruhe Institute of Technology, Postfach 6980, 76128 Karlsruhe (Germany); Hessling, Hermann [HTW Berlin, University of Applied Sciences, 10318 Berlin (Germany); Kemp, Yves; Synge, Owen, E-mail: Oliver.Oberst@iwr.fzk.d [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

    2010-04-01

    Current experiments in HEP only use a limited number of operating system flavours. Their software might only be validated on one single OS platform. Resource providers might have other operating systems of choice for the installation of the batch infrastructure. This is especially the case if a cluster is shared with other communities, or communities that have stricter security requirements. One solution would be to statically divide the cluster into separated sub-clusters. In such a scenario, no opportunistic distribution of the load can be achieved, resulting in a poor overall utilization efficiency. Another approach is to make the batch system aware of virtualization, and to provide each community with its favoured operating system in a virtual machine. Here, the scheduler has full flexibility, resulting in a better overall efficiency of the resources. In our contribution, we present a lightweight concept for the integration of virtual worker nodes into standard batch systems. The virtual machines are started on the worker nodes just before jobs are executed there. No meta-scheduling is introduced. We demonstrate two prototype implementations, one based on the Sun Grid Engine (SGE), the other using Maui/Torque as a batch system. Both solutions support local job as well as Grid job submission. The hypervisors currently used are Xen and KVM, a port to another system is easily envisageable. To better handle different virtual machines on the physical host, the management solution VmImageManager is developed. We will present first experience from running the two prototype implementations. In a last part, we will show the potential future use of this lightweight concept when integrated into high-level (i.e. Grid) work-flows.

  15. Effects of Replenishing Qi, Promoting Blood Circulation and Resolving Phlegm on Vascular Endothelial Function and Blood Coagulation System in Senile Patients with Hyperlipemia

    Institute of Scientific and Technical Information of China (English)

    Yang Huimin; Han Libei; Sheng Tong; He Qiong; Liang Jinpu

    2006-01-01

    Objective: To observe the curative effect of the method of replenishing qi, promoting blood circulation and resolving phlegm on senile hyperlipemia and its effects on vascular endothelial function and blood coagulation system. Method: 96 patients with senile hyperlipemia were randomly divided into a treatment group and a of blood lipid, vascular endothelial function, blood coagulation system and safety. Results: After treatment,the treatment group was obviously superior to the control group (P<0.05) in reducing plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as well as in the ratio of thromboxane B2 (TXB2) to 6-keto-prostaglandin F1α (6-keto-PGF1α), D-dimer (D-D) and fibrinogen (FIB). Conclusion: Danshen Jueming Granules have the effect of regulating metabolism of blood lipid, and improving vascular endothelial function and blood coagulation system in senile patients with hyperlipemia.

  16. National System of Standard Reference Data in Korea

    International Nuclear Information System (INIS)

    National Center for Standard Reference Data (NCSRD) was established in 2006 by law, based on the Fundamental Act for National Standard. The motivation of establishment was caused by the demand from the industry for data with a guaranteed quality. As is well known, Korean industry has grown very fast during the last 50 years. They begin to realize that data with a high quality is very essential in good design and manufacturing of high quality products. At the same time, the standard of living has increased in parallel with the development of industry. People begin to be concerned about health diagnosis, food products, and environment. This concern about quality of life naturally leads to an interest on the reference data related with health and the environment. To satisfy these demands from the industry as well as from the people, the Korean government decided to establish a national system for the evaluation of data quality produced by the R and D institutes and universities. NCSRD coordinates all the national activities regarding evaluation and dissemination of scientific data by law. The primary goal of the NCSRD is to develop and disseminate standard reference data which are critically evaluated for their reliability by experts for use in technical problem-solving, research and development. NCSRD consist of a steering committee (SC), spectral technical committees (TCs) and data centres. Right now there are 22 data centres designated by the Minister of Knowledge and Economics (MKE) and 24 technical committees for data evaluation. The Steering Committee acts as the top decision-making body of the SRD program. The members of the SC consist of 11 experts from universities, research institutes and industries. Technical committees in each area serve as an expert group to deal with data-related matters such as evaluation of the reliability of the collected or measured data, development of detailed data evaluation guidelines in each area, etc. The detailed data

  17. [Development of laboratory information system--quality standards].

    Science.gov (United States)

    Srenger, Vesna; Stavljenić-Rukavina, Ana; Cvorisćec, Dubravka; Brkljacić, Vera; Rogić, Dunja; Juricić, Ljiljana

    2005-01-01

    The aim of the study was to determine structural modules of laboratory information system (LIS) for the application of new biomedical and information technologies by utilizing current organizational trends. The method used included definition of structural modules according to significant LIS properties, e.g., a large number of data, automation of analyses and rapid exchange of information, and according to the process of information establishment the collection, organization, selection, synthesis and distribution. Thus, outdated distributed software at the Clinical Institute of Laboratory Diagnosis has now been replaced by modular organization. Modules have been developed for the following: data input, online operation of laboratory instruments, preparation of results, compilation of medical documentation on quality assurance based on the application of quality standards, management of finances, and for point of care testing. The method of re-engineering as well as adherence to EN and ISO quality standards were utilized in planning the development of LIS based on the application of new information technologies and in shaping business processes. The application of re-engineering in LIS development results in quality improvement, reduces the cost and time necessary for performance of procedures, and improves relations in organizational structure.

  18. Ambulatory Blood Pressure Monitoring (ABPM) as the reference standard for diagnosis of hypertension and assessment of vascular risk in adults.

    Science.gov (United States)

    Hermida, Ramón C; Smolensky, Michael H; Ayala, Diana E; Portaluppi, Francesco

    2015-01-01

    New information has become available since the ISC, AAMCC, and SECAC released their first extensive guidedelines to improve the diagnosis and treatment of adult arterial hypertension. A critical assessment of evidence and a comparison of what international guidelines now propose are the basis for the following statements, which update the recommendations first issued in 2013. Office blood pressure (BP) measurements should no longer be considered to be the "gold standard" for the diagnosis of hypertension and assessment of cardiovascular risk. Relying on office BP, even when supplemented with at-home wake-time self-measurements, to identify high-risk individuals, disregarding circadian BP patterning and asleep BP level, leads to potential misclassification of 50% of all evaluated persons. Accordingly, ambulatory BP monitoring is the recommended reference standard for the diagnosis of true hypertension and accurate assessment of cardiovascular risk in all adults ≥18 yrs of age, regardless of whether office BP is normal or elevated. Asleep systolic BP mean is the most significant independent predictor of cardiovascular events. The sleep-time relative SBP decline adds prognostic value to the statistical model that already includes the asleep systolic BP mean and corrected for relevant confounding variables. Accordingly, the asleep systolic BP mean is the recommended protocol to diagnose hypertension, assess cardiovascular risk, and predict cardiovascular event-free interval. In men, and in the absence of compelling clinical conditions, reference thresholds for diagnosing hypertension are 120/70 mmHg for the asleep systolic/diastolic BP means derived from ambulatory BP monitoring. However, in women, in the absence of complicating co-morbidities, the same thresholds are lower by 10/5 mmHg, i.e., 110/65 mmHg for the asleep means. In high-risk patients, including those diagnosed with diabetes or chronic kidney disease, and/or those having experienced past

  19. Blood Pressure Mobile Monitoring for Pregnant Woman Based Android System

    Science.gov (United States)

    Supriyanti, Retno; Erfayanto, Uji; Ramadani, Yogi; Murdyantoro, Eko; Widodo, Haris B.

    2016-01-01

    Currently, at least 18,000 women die every year in Indonesia due to pregnancy or childbirth. It means that every half hour a woman dies due to pregnancy or childbirth. As a result, every year 36,000 children became orphans. The high maternal mortality rate was put Indonesia on top in ASEAN. The main causes of maternal mortality are high-risk pregnancy. Mothers who have diseases like high blood pressure, pre-eclampsia, diabetes, hyperthyroidism, and already over 40 years old and infectious diseases such as rubella, hepatitis and HIV can be factors that lead to high-risk pregnancy. This paper will discuss the development of a blood pressure monitoring device that is suitable for pregnant women. It is based on convenience for pregnant women to get the equipment that is flexible with her presence. Results indicate that the equipment is in use daily support for pregnant women therefore, one of the causes of maternal mortality can be detected earlier.

  20. FEQ for Standard OFDM Systems with Insufficient CP

    Institute of Scientific and Technical Information of China (English)

    CHENShaoping; YAOTianren

    2004-01-01

    In Orthogonai frequency division multiplexing (OFDM) systems, when the length of the Cyclic prefix (CP) is shorter than the channel length, there exist Intersymbol interference (ISI) and Interchannel interference (ICI) and the one-tap frequency domain equalizer is not applicable any more. A Time-domain equalizer (TEQ) is usually used in the receiver to reduce the duration of the overall response of the transmission system, and therefore minimize the ISI and ICI. However, the optimum design of TEQ turns out to be a difficult task. In this paper, we propose a Frequency domain equalizer (FEQ) for standard OFDM systems with insufficient CP by employing the null side sub-carriers and CP redundancy. The equalizer has a sparse matrix structure and thus a low computational complexity. Theoretical anaiysis and simulation results indicate that it can efficiently remove ISI and ICI caused by insufficient CP and recover the transmitted data. Moreover, we derive the condition for the existence and uniqueness of FEQ, i.e., the combined length of CP and null subcarriers is not shorter than the channel order, which means that the insufficiency of CP in time domain can be compensated by the redundancy in frequency domain.

  1. Development of portable health monitoring system for automatic self-blood glucose measurement

    Science.gov (United States)

    Kim, Huijun; Mizuno, Yoshihumi; Nakamachi, Eiji; Morita, Yusuke

    2010-02-01

    In this study, a new HMS (Health Monitoring System) device is developed for diabetic patient. This device mainly consists of I) 3D blood vessel searching unit and II) automatic blood glucose measurement (ABGM) unit. This device has features such as 1)3D blood vessel location search 2) laptop type, 3) puncturing a blood vessel by using a minimally invasive micro-needle, 4) very little blood sampling (10μl), and 5) automatic blood extraction and blood glucose measurement. In this study, ABGM unit is described in detail. It employs a syringe type's blood extraction mechanism because of its high accuracy. And it consists of the syringe component and the driving component. The syringe component consists of a syringe itself, a piston, a magnet, a ratchet and a micro-needle whose inner diameter is about 80μm. And the syringe component is disposable. The driving component consists of body parts, a linear stepping motor, a glucose enzyme sensor and a slider for accurate positioning control. The driving component has the all-in-one mechanism with a glucose enzyme sensor for compact size and stable blood transfer. On designing, required thrust force to drive the slider is designed to be greater than the value of the blood extraction force. Further, only one linear stepping motor is employed for blood extraction and transportation processes. The experimental result showed more than 80% of volume ratio under the piston speed 2.4mm/s. Further, the blood glucose was measured successfully by using the prototype unit. Finally, the availability of our ABGM unit was confirmed.

  2. Study on Designing Standards System Framework of Hainan National Breeding and Multiplication

    Institute of Scientific and Technical Information of China (English)

    Guanming CHE; Jing YANG; Yaqiong LIN; Liping WANG; Jinsong LI1

    2012-01-01

    A preliminary feasibility study was set up for the HNBM standard system. By introducing the set theory and basic methods of the solid geometry and adopting the Verman three-dimensional structure ideology innovatively, the standards system of Hainan National Breeding and Multiplication (HNBM) was studied with the four-di- mensional structure and integration by combining with the time dimension. The four- dimensional structure standards system will be useful for guiding the construction of the HNBM standards system, carrying on the division of labor and realizing the dy- namic development of the standards system. The standards set of HNBM helps to computer programming and information

  3. Non-standard vacuum hardware for an accelerator vacuum system

    International Nuclear Information System (INIS)

    The metal sealed demountable joints of the LEP vacuum system have been proposed and designed in such a way that well-proven stainless steel components like pumps, valves, gauges or bellows could be joined without transition pieces onto the aluminium vacuum chambers. Important boundary conditions which were imposed by the operation parameters were corrosion and temperature resistance with the general demand for a high standard of reliability which had to be assured despite the considerable differential expansion caused by the dissimilar flange materials at elevated temperature. 2800 bellows compensate alignment tolerances and the length increase of the aluminium chambers during bake-outs. Their circular aperture would create 2800 cavities of an inadmissible transverse impedance. An inner screen has therefore been designed which provides a reliable electrical contact under all working conditions of LEP and which keeps the elliptical aperture of the beam path quasi-constant, such eliminating higher order mode losses, which would otherwise be induced by the passage of charged particles. The report describes the design and technology of these components and their performance in the ultra-high vacuum system of LEP. (author)

  4. Noninvasive cerebral blood oxygenation monitoring: clinical test of multiwavelength optoacoustic system

    Science.gov (United States)

    Petrov, Y. Y.; Prough, D. S.; Petrova, I.; Patrikeev, I. A.; Cicenaite, I.; Esenaliev, R. O.

    2007-02-01

    Continuous monitoring of cerebral blood oxygenation is critically important for treatment of patients with life-threatening conditions like severe brain injury or during cardiac surgery. We designed and built a novel multiwavelength optoacoustic system for noninvasive, continuous, and accurate monitoring of cerebral blood oxygenation. We use an Optical Parametric Oscillator as a light source. We successfully tested the system in vitro as well as in vivo in large animals (sheep) through thick tissues overlying blood vessels which drain venous blood out of the brain (e.g., superior sagittal sinus or jugular vein). Here we present the results of clinical tests of the system for continuous noninvasive cerebral blood oxygenation monitoring in the internal jugular vein of healthy volunteers. We applied our custom-built optoacoustic probe (which incorporated a wide-band acoustic transducer and an optical fiber) to the neck area overlying the internal jugular vein. We performed measurements with volunteers at 18 wavelengths in the near-infrared spectral range. Despite a thick layer of overlying connective tissue and low energy used in the experiments, we recorded signals with high signal-to-noise ratios for all volunteers. We found that the temporal (independent of signal amplitude) parameters of recorded profiles for different levels of blood oxygenation correlated well with the spectrum of effective attenuation coefficients of blood.

  5. 78 FR 74162 - Draft Criminal Justice Offender Tracking System Standard and Companion Documents

    Science.gov (United States)

    2013-12-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Draft Criminal Justice Offender Tracking System Standard and Companion Documents... draft documents: (1) A draft standard entitled, ``Criminal Justice Offender Tracking System...

  6. 75 FR 78269 - Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard for Law Enforcement

    Science.gov (United States)

    2010-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard for Law... the general public the draft ``Vehicular Digital Multimedia Evidence Recording System Standard for...

  7. 76 FR 52350 - Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard, Certification Program...

    Science.gov (United States)

    2011-08-22

    ... of Justice Programs Vehicular Digital Multimedia Evidence Recording System (VDMERS) Standard...) will make available to the general public three draft documents related to Vehicular Digital Multimedia Evidence Recording Systems (VDMERSs) used by law enforcement agencies: 1. Draft VDMERS Standard for...

  8. Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis

    DEFF Research Database (Denmark)

    Møller, S; Bendtsen, F; Henriksen, Jens Henrik Sahl

    1995-01-01

    BACKGROUND & AIMS: Systemic vasodilatation in cirrhosis may lead to hemodynamic alterations with reduced effective blood volume and decreased arterial blood pressure. This study investigates the response of acute volume expansion on hemodynamics and regional blood volumes in patients with cirrhosis......, and arterial pressure were determined before and during a volume expansion induced by infusion of a hyperosmotic galactose solution. RESULTS: During volume expansion, the central and arterial blood volume increased significantly in patients with class A and controls, whereas no significant change was found....... CONCLUSIONS: Only in mild cirrhosis is the effective blood volume able to increase in response to volume expansion. Our results are consistent with the peripheral vasodilatation hypothesis and the circulatory hyporeactivity occurring in advanced cirrhosis....

  9. Performance of the CellaVision ® DM96 system for detecting red blood cell morphologic abnormalities

    Directory of Open Access Journals (Sweden)

    Christopher L Horn

    2015-01-01

    Full Text Available Background: Red blood cell (RBC analysis is a key feature in the evaluation of hematological disorders. The gold standard light microscopy technique has high sensitivity, but is a relativity time-consuming and labor intensive procedure. This study tested the sensitivity and specificity of gold standard light microscopy manual differential to the CellaVision ® DM96 (CCS; CellaVision, Lund, Sweden automated image analysis system, which takes digital images of samples at high magnification and compares these images with an artificial neural network based on a database of cells and preclassified according to RBC morphology. Methods: In this study, 212 abnormal peripheral blood smears within the Calgary Laboratory Services network of hospital laboratories were selected and assessed for 15 different RBC morphologic abnormalities by manual microscopy. The same samples were reassessed as a manual addition from the instrument screen using the CellaVision ® DM96 system with 8 microscope high power fields (×100 objective and a 22 mm ocular. The results of the investigation were then used to calculate the sensitivity and specificity of the CellaVision ® DM96 system in reference to light microscopy. Results: The sensitivity ranged from a low of 33% (RBC agglutination to a high of 100% (sickle cells, stomatocytes. The remainder of the RBC abnormalities tested somewhere between these two extremes. The specificity ranged from 84% (schistocytes to 99.5% (sickle cells, stomatocytes. Conclusions: Our results showed generally high specificities but variable sensitivities for RBC morphologic abnormalities.

  10. IRON CONCENTRATIONS IN SOIL, PASTURE AND BLOOD PLASMA OF BEEF CATTLE REARED IN SUCKLING COWS SYSTEM

    Directory of Open Access Journals (Sweden)

    Aleš Pavlík

    2013-02-01

    Full Text Available The objective of this study was to compare concentrations of iron (Fe in soil, pasture sward and blood plasma of extensive reared Aberdeen Angus bulls and heifers on a farm in the foothills of the Orlické Mountains. We sampled soil, pasture sward from pasture areas and blood from 22 bulls and 22 heifers in the period from birth to weaning at regular intervals (81, 151, 189 and 273 days of age. Concentrations of iron were analysed. Not significant relationships were noted between soil and pasture iron concentrations (r = 0.32, pasture and blood plasma iron concentration (r = 0.39. In this study, there were not found relationships between iron-soil, forage and blood concentration in beef cattle reared in suckling cows The objective of this study was to compare concentrations of iron (Fe in soil, pasture sward and blood plasma of extensive reared Aberdeen Angus bulls and heifers on a farm in the foothills of the Orlické Mountains. We sampled soil, pasture sward from pasture areas and blood from 22 bulls and 22 heifers in the period from birth to weaning at regular intervals (81, 151, 189 and 273 days of age. Concentrations of iron were analysed. Not significant relationships were noted between soil and pasture iron concentrations (r = 0.32, pasture and blood plasma iron concentration (r = 0.39. In this study, there were not found relationships between iron-soil, forage and blood concentration in beef cattle reared in suckling cows system.

  11. 49 CFR 571.213 - Standard No. 213; Child restraint systems.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.213 Standard No. 213; Child restraint systems. S1. Scope. This... vehicle crashes and in aircraft. S3. Application. This standard applies to passenger cars, multipurpose.... S4. Definitions. Add-on child restraint system means any portable child restraint system....

  12. 42 CFR 493.1239 - Standard: General laboratory systems quality assessment.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: General laboratory systems quality... HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing General Laboratory Systems § 493.1239 Standard: General laboratory...

  13. A Research on the Standardization of Management of Human Resource Information System

    OpenAIRE

    Hongbiao Xu; Fuqian Shi

    2009-01-01

    We bring up the standardization of the human resources management information system; A norm of human resources management strategy and a set of standardized system will be created. It’s indicated clearly that the standardization of Human resources management information system is essential in enterprises’development. And it will be the cornerstone of the further development of enterprises.

  14. Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) in blood donors of south Gujarat, India

    OpenAIRE

    Manoj A Kahar; Patel, Rajnikant. D.

    2014-01-01

    Background: This is the first study on phenotype frequencies of various blood group systems in blood donors of south Gujarat, India using conventional tube technique. Material and Methods: A total of 115 "O" blood group donors from three different blood banks of south Gujarat were typed for D, C, c, E, e, K, Jk a , Le a , Le b , P 1 , M, and N antigens using monoclonal antisera and k, Kp a , Kp b , Fy a ,Fy b , Jk b , S,s, Lu a , and Lu b antigens were typed using polyclonal antisera employin...

  15. Business transactions and standards : towards a system of concepts and a method for early problem identification in standard implementation projects

    NARCIS (Netherlands)

    Rukanova, Boriana

    2005-01-01

    To summarize, with respect to research question one we constructed a system of concepts, while in answer to research question two we proposed a method of how to apply this system of concepts in practice in order to identify potential problems in early stages of standard implementation projects.

  16. Risk in Management Systems according to ISO standard

    Directory of Open Access Journals (Sweden)

    P. Królas

    2010-07-01

    Full Text Available The purpose of this article was to present selected management standards in context of risk management. It presents main ISOmanagement standards (ISO 9001, ISO 14001, OHSAS 18001, ISO 27001, BS 25999, ISO 31000 that apply to polish enterprises. In thefirst part of this article there are analyzed management standards regarding quality, environment, occupational health and safety,information security, as well as business continuity management and risk management. The second part of the article discusses the processof dealing with risk based on chosen management standard.

  17. Does the practice of blood film microscopy for detection and quantification of malaria parasites in northwest Ethiopia fit the standard?

    OpenAIRE

    Biadglegne, Fantahun; Belyhun, Yeshambel; Ali, Jemal; Walle, Fisha; Gudeta, Nigussu; Kassu, Afework; Mulu, Andargachew

    2014-01-01

    Background The diagnosis of malaria in clinical laboratories mainly depends on blood smear microscopy and this technique remains the most widely used in Ethiopia. Despite the importance of blood smear microscopy for patient’s diagnosis and treatment, little effort has been made to precisely determine and identify sources of error in malaria smear microscopic diagnosis and quantification of parasitaemia. The main objective of the present study was to assess the laboratory practices of health c...

  18. Blood compounds irradiation process: assessment of absorbed dose using Fricke and Thermoluminescent dosimetric systems

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Gabriela de Amorim; Squair, Peterson Lima; Pinto, Fausto Carvalho; Belo, Luiz Claudio Meira; Grossi, Pablo Andrade [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN-CNEN/MG), Belo Horizonte, MG (Brazil)], e-mail: gas@cdtn.br, e-mail: pls@cdtn.br, e-mail: fcp@cdtn.br, e-mail: lcmb@cdtn.br, e-mail: pabloag@cdtn.br

    2009-07-01

    The assessment of gamma absorbed doses in irradiation facilities allows the quality assurance and control of the irradiation process. The liability of dose measurements is assign to the metrological procedures adopted including the uncertainty evaluation. Fricke and TLD 800 dosimetric systems were used to measure absorbed dose in the blood compounds using the methodology presented in this paper. The measured absorbed doses were used for evaluating the effectiveness of the irradiation procedure and the gamma dose absorption inside the irradiation room of a gamma irradiation facility. The radiation eliminates the functional and proliferative capacities of donor T-lymphocytes, preventing Transfusion associated graft-versus-host disease (TA-GVHD), a possible complication of blood transfusions. The results show the applicability of such dosimetric systems in quality assurance programs, assessment of absorbed doses in blood compounds and dose uniformity assign to the blood compounds irradiation process by dose measurements in a range between 25 Gy and 100 Gy. (author)

  19. HEMOS: an expert support system prototype for forecasting blood requirements for Marine Corps medical support/

    OpenAIRE

    Greenauer, Michael A.

    1988-01-01

    Research was conducted to demonstrate the applicability of artificial intelligence techniques to the problem of estimating blood resupply requirements in Navy medical units supporting Marine Corps commands engaged in combat operations. Prototyping methodology was used to develop a combination expert system and decision support system, termed an expert support system, which was named HEMOS (Hemologic Expert Support System for Marine Corps Operational Support). The prototype system was tested a...

  20. Standardized emergency management system and response to a smallpox emergency.

    Science.gov (United States)

    Kim-Farley, Robert J; Celentano, John T; Gunter, Carol; Jones, Jessica W; Stone, Rogelio A; Aller, Raymond D; Mascola, Laurene; Grigsby, Sharon F; Fielding, Jonathan E

    2003-01-01

    The smallpox virus is a high-priority, Category-A agent that poses a global, terrorism security risk because it: (1) easily can be disseminated and transmitted from person to person; (2) results in high mortality rates and has the potential for a major public health impact; (3) might cause public panic and social disruption; and (4) requires special action for public health preparedness. In recognition of this risk, the Los Angeles County Department of Health Services (LAC-DHS) developed the Smallpox Preparedness, Response, and Recovery Plan for LAC to prepare for the possibility of an outbreak of smallpox. A unique feature of the LAC-DHS plan is its explicit use of the Standardized Emergency Management System (SEMS) framework for detailing the functions needed to respond to a smallpox emergency. The SEMS includes the Incident Command System (ICS) structure (management, operations, planning/intelligence, logistics, and finance/administration), the mutual-aid system, and the multi/interagency coordination required during a smallpox emergency. Management for incident command includes setting objectives and priorities, information (risk communications), safety, and liaison. Operations includes control and containment of a smallpox outbreak including ring vaccination, mass vaccination, adverse events monitoring and assessment, management of confirmed and suspected smallpox cases, contact tracing, active surveillance teams and enhanced hospital-based surveillance, and decontamination. Planning/intelligence functions include developing the incident action plan, epidemiological investigation and analysis of smallpox cases, and epidemiological assessment of the vaccination coverage status of populations at risk. Logistics functions include receiving, handling, inventorying, and distributing smallpox vaccine and vaccination clinic supplies; personnel; transportation; communications; and health care of personnel. Finally, finance/administration functions include monitoring

  1. The Rheology of Blood Flow in a Branched Arterial System.

    Science.gov (United States)

    Shibeshi, Shewaferaw S; Collins, William E

    2005-01-01

    Blood flow rheology is a complex phenomenon. Presently there is no universally agreed upon model to represent the viscous property of blood. However, under the general classification of non-Newtonian models that simulate blood behavior to different degrees of accuracy, there are many variants. The power law, Casson and Carreau models are popular non-Newtonian models and affect hemodynamics quantities under many conditions. In this study, the finite volume method is used to investigate hemodynamics predictions of each of the models. To implement the finite volume method, the computational fluid dynamics software Fluent 6.1 is used. In this numerical study the different hemorheological models are found to predict different results of hemodynamics variables which are known to impact the genesis of atherosclerosis and formation of thrombosis. The axial velocity magnitude percentage difference of up to 2 % and radial velocity difference up to 90 % is found at different sections of the T-junction geometry. The size of flow recirculation zones and their associated separation and reattachment point's locations differ for each model. The wall shear stress also experiences up to 12 % shift in the main tube. A velocity magnitude distribution of the grid cells shows that the Newtonian model is close dynamically to the Casson model while the power law model resembles the Carreau model. ZUSAMMENFASSUNG: Die Rheologie von Blutströmungen ist ein komplexes Phänomen. Gegenwärtig existiert kein allgemein akzeptiertes Modell, um die viskosen Eigenschaften von Blut wiederzugeben. Jedoch gibt es mehrere Varianten unter der allgemeinen Klassifikation von nicht-Newtonschen Modellen, die das Verhalten von Blut mit unterschiedlicher Genauigkeit simulieren. Die Potenzgesetz-, Casson und Carreau-Modelle sind beliebte nicht-New-tonsche Modelle und beeinflussen die hämodynamischen Eigenschaften in vielen Situationen. In dieser Studie wurde die finite Volumenmethode angewandt, um die h

  2. Simultaneous Pulmonary and Systemic Blood Pressure and ECG Interval Measurement in Conscious, Freely Moving Rats

    OpenAIRE

    Rey, Markus; Weber, Edgar W; Hess, Patrick D

    2012-01-01

    Here we evaluated the ability of a new, dual blood-pressure telemetry transmitter to simultaneously measure pulmonary and systemic blood pressure and the electrocardiogram in rats. The transmitter was implanted in normotensive and monocrotaline-induced pulmonary hypertensive Wistar rats, with sensing catheters placed in the pulmonary artery (channel 1) and descending aorta (channel 2). Biopotential electrodes were positioned to record an apex-based lead II electrocardiogram. Pulmonary and sys...

  3. 40 CFR 63.172 - Standards: Closed-vent systems and control devices.

    Science.gov (United States)

    2010-07-01

    ... olfactory indications of leaks. (2) If the vapor collection system or closed-vent system is constructed of... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Standards: Closed-vent systems and... Standards: Closed-vent systems and control devices. (a) Owners or operators of closed-vent systems...

  4. Effect of humic-plant feed preparations on biochemical blood parameters of laying hens in deep litter housing system.

    Science.gov (United States)

    Bubel, F; Dobrzański, Z; Gaweł, A; Pogoda-Sewerniak, K; Grela, E R

    2015-01-01

    An influence of various humic-plant feed additives based on some herbs (nettle, chamomile, yarrow, perforatum), lucerne and humic materials on biochemical indices of Lohmann Brown (LB) layers blood plasma was estimated. Hens were housed in deep litter system, 20 birds in a group. Four groups were formed: control (C - standard feeding), and experimental, supplemented with prepara- tions: E-1 herbal-humic, E-2 humic-herbal and E-3--humic-lucerne. Hens were placed in the pens on the 16th week of life, addition of preparations with standard food mixture started at the 22nd wk and lasted until 66th wk of life. Blood for analyses was collected four times in the following periods: 27, 37, 54 and 65th wk of life. The applied humic-plant preparations to a limited degree affected the values of examined biochemical parameters in serum: total protein (TP), albumins (Albs), glucose (Glu), urea, triacylglycerols (TAG), total cholesterol (TCh), alanine aminotransferase (ALT), aspartate aminot- ransferase (AST) and alkaline phosphatase (ALP). It is difficult to determine based on these study, which preparation is one the most active biologically, however is seems that humic-lucerne prepara- tion affected the examined blood parameters to the highest degree. The reference values ranges in hens blood serum LB hens were proposed for: TP (43-65 g/l), Albs (15-22 g/l), urea (0.5-1.2 mmol/l), Glu 10-15 mmol/l), TCh (2.2-4.5 mmol/l), TAG (10-24 mmol/l), AST (4-12 U/l), ALT (150-280 mmol/l) and ALP (190-350 U/l).

  5. True color blood flow imaging using a high-speed laser photography system

    Science.gov (United States)

    Liu, Chien-Sheng; Lin, Cheng-Hsien; Sun, Yung-Nien; Ho, Chung-Liang; Hsu, Chung-Chi

    2012-10-01

    Physiological changes in the retinal vasculature are commonly indicative of such disorders as diabetic retinopathy, glaucoma, and age-related macular degeneration. Thus, various methods have been developed for noninvasive clinical evaluation of ocular hemodynamics. However, to the best of our knowledge, current ophthalmic instruments do not provide a true color blood flow imaging capability. Accordingly, we propose a new method for the true color imaging of blood flow using a high-speed pulsed laser photography system. In the proposed approach, monochromatic images of the blood flow are acquired using a system of three cameras and three color lasers (red, green, and blue). A high-quality true color image of the blood flow is obtained by assembling the monochromatic images by means of image realignment and color calibration processes. The effectiveness of the proposed approach is demonstrated by imaging the flow of mouse blood within a microfluidic channel device. The experimental results confirm the proposed system provides a high-quality true color blood flow imaging capability, and therefore has potential for noninvasive clinical evaluation of ocular hemodynamics.

  6. Simultaneous identification and quantification of new psychoactive substances in blood by GC-APCI-QTOFMS coupled to nitrogen chemiluminescence detection without authentic reference standards.

    Science.gov (United States)

    Ojanperä, Ilkka; Mesihää, Samuel; Rasanen, Ilpo; Pelander, Anna; Ketola, Raimo A

    2016-05-01

    A novel platform is introduced for simultaneous identification and quantification of new psychoactive substances (NPS) in blood matrix, without the necessity of using authentic reference standards. The instrumentation consisted of gas chromatography (GC) coupled to nitrogen chemiluminescence detection (NCD) and atmospheric pressure chemical ionization quadrupole time-of-flight mass spectrometry (APCI-QTOFMS). In this concept, the GC flow is divided in appropriate proportions between NCD for single-calibrant quantification, utilizing the detector's equimolar response to nitrogen, and QTOFMS for accurate mass-based identification. The principle was proven by analyzing five NPS, bupropion, desoxypipradrol (2-DPMP), mephedrone, methylone, and naphyrone, in sheep blood. The samples were spiked with the analytes post-extraction to avoid recovery considerations at this point. All the NPS studies produced a protonated molecule in APCI resulting in predictable fragmentation with high mass accuracy. The N-equimolarity of quantification by NCD was investigated by using external calibration with the secondary standard caffeine at five concentration levels between 0.17 and 1.7 mg/L in blood matrix as five replicates. The equimolarity was on average 98.7%, and the range of individual equimolarity determinations was 76.7-130.1%. The current analysis platform affords a promising approach to instant simultaneous qualitative and quantitative analysis of drugs in the absence of authentic reference standards, not only in forensic and clinical toxicology but also in other bioanalytical applications.

  7. 49 CFR 571.121 - Standard No. 121; Air brake systems.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.121 Standard No. 121; Air brake systems. S1. Scope. This standard... emergency conditions. S3. Application. This standard applies to trucks, buses, and trailers equipped with... definition of heavy hauler trailer set forth in S4; (f) Any trailer that has an unloaded vehicle weight...

  8. 49 CFR 571.301 - Standard No. 301; Fuel system integrity.

    Science.gov (United States)

    2010-10-01

    ... S8 of Standard 214 (49 CFR 571.214). S7.3Rear moving barrier test conditions. (a) Vehicles... conditions are those specified in S8.2 of Standard No. 208 (49 CFR 571.208). (b) Vehicles manufactured on or... Motor Vehicle Safety Standards § 571.301 Standard No. 301; Fuel system integrity. S1. Scope....

  9. A Digital Method for the Detection of Blood Flow Direction in Ultrasonic Doppler Systems

    Directory of Open Access Journals (Sweden)

    P. Acevedo–Contla.

    2010-01-01

    Full Text Available Doppler ultrasound systems are widely used to study blood flow and diagnosis of vascular diseases. An important characteristic of these systems is the ability to detect the direction of the blood flow. Most Doppler ultrasound systems apply a quadrature demodulation technique on the ultrasonic transducer output signal. Therefore additional treatment is necessary to separate forward and reverse flow signals. This work presents a digital method to convert signals in quadrature into directional signals using a Fast Fourier Transform (FFT approach. Validation of the method has been achieved using simulated Doppler ultrasound signals.

  10. An intelligent system for continuous blood pressure monitoring on remote multi-patients in real time

    OpenAIRE

    Marani, Roberto; Perri, Anna Gina

    2012-01-01

    In this paper we present an electronic system to perform a non-invasive measurement of the blood pressure based on the oscillometric method, which does not suffer from the limitations of the well-known auscultatory one. Moreover the proposed system is able to evaluate both the systolic and diastolic blood pressure values and makes use of a microcontroller and a Sallen-Key active filter. With reference to other similar devices, a great improvement of our measurement system is achieved since it...

  11. Discussion about the standard system on urban domestic water saving technology in China

    Institute of Scientific and Technical Information of China (English)

    YANG Shujun; REN Xiaoli; GAO Benhu

    2007-01-01

    Standard is the technical foundation of national economic and social development, and it is the basic rule of establishing social regulation.Researching and constituting the standard system of urban domestic water saving technology is to offer important science basis for revising standard plan and standardize research plan. This paper introduces the present situation of our urban domestic water saving technical standard system, problem and the development direction in the future, as well as project planning of constructing urban domestic water saving technical standard system.

  12. A Standards System for the Protection and Utilization of Wild Fauna and Flora in China

    Institute of Scientific and Technical Information of China (English)

    Zhang Xinjie

    2007-01-01

    This paper analyzed the current state of protection and utilization of wild fauna and flora and its standardization. The principles needed to establish a standardized system for the protection and utilization of wild fauna and flora were put forward. A comprehensive standards system consisting of the basic standards, technical regulations, and various other standards related to products, epidemic disease prevention and control,first-aid and propagation, viewing and hunting was proposed. Such a standards system will play an important role for wild fauna and flora protection and utilization in China.

  13. Reviewing Consensus HFE Standards for NRC Use: A Case Study using the IEEE Standard for Computerized Operating Procedure Systems

    Energy Technology Data Exchange (ETDEWEB)

    OHara, J.M.; Higgins, J.; Xing, J., Fleger S. - NRC

    2010-11-07

    The U.S. Nuclear Regulatory Commission’s (NRC’s) endorsement of consensus standards provides a cost-effective means of enhancing the staff’s ability to review state-of-the-art designs. Although the NRC endorsed consensus standards in many technical disciplines, it yet has to do so in human factors engineering (HFE). The purpose of our study was to develop a standardized methodology whereby to evaluate a consensus HFE standard to determine its appropriateness to, and adequacy for using in licensing reviews. The high-level objective of the methodology is to ensure that the guidance meets the NRC’s requirements on scientific- and engineering-rigor that they use in developing their own guidance. We propose four criteria for endorsing a consensus standard: (1) It should meet an existing need for NRC’s licensing and safety reviews; (2) it should be based on sound HFE principles; (3) it should be thoroughly peer-reviewed; and, (4) it should address human performance issues identified in the literature. Our methodology offers a means to assess these four criteria. We used it to evaluate an Institute of Electrical and Electronics Engineers’ (IEEE) draft standard on computerized operating procedure systems. We concluded that the IEEE standard generally met the established criteria, although several areas were identified that needed further clarification. Our evaluation methodology particularly was useful for identifying issues to be resolved, and for providing a basis for judging whether the staff should consider endorsing the standard. The methodology also helped recognize criteria in the proposed standard that may benefit from additional scrutiny by the staff. The evaluation methodology developed is applicable generally to reviewing other HFE standards that the NRC is considering for use or endorsement.

  14. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

    OpenAIRE

    Ravi Kant Upadhyay

    2014-01-01

    Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations insi...

  15. Automatic system for blood donors control with seropositive results in epidemiological tests.

    Directory of Open Access Journals (Sweden)

    Ariel Menéndez Barrios

    2008-04-01

    Full Text Available Background: Prevention of infectious diseases transmission through blood transfusion is one of the biggest challenges in the transfusion field of medicine. Objective: to design a computerized system for blood donors control with seropositive results in epidemiological tests. Methods: A system designed by the Provincial Blood Bank using Microsoft Access as a data base system and DELFHI 7 as associated language. It runs under Windows 2000 or any other superior system with 64 RAM and do not need special requirements of software or hardware. It includes the following data: Full name, age, sex, race, Id number, home address, number of the clinical record in the blood bank, date when the trial took place in each patient, kind of disease diagnosed, technical data of the trial such as: fluorescence, sectional level of the 1st trial as well as the repetition, name of the technician who performed it. Results: It permits to consult general data of donors as well as the disease diagnosed. It also permits to elaborate reports of these patients from any PC of the blood bank acceding with the security password of the program. Conclusions: It constitutes a beneficial tool which permits to improve the notification system established in the program of the web about sexually transmitted diseases from the Minister of Public Health in Cuba.

  16. A hemolysis study of an intravascular blood cooling system for localized organ tissue cooling.

    Science.gov (United States)

    Merrill, T L; Mingin, T; Merrill, D R; Botbyl, J; Akers, J E

    2013-01-01

    Therapeutic hypothermia can reduce both ischemic and reperfusion injury arising after strokes and heart attacks. New localized organ cooling systems offer a way to reduce tissue damage more effectively with fewer side effects. To assess initial blood safety of our new organ cooling system, the CoolGuide Cooling System (CCS), we investigated safe operating conditions and configurations from a hemolysis perspective. The CCS consists of a peristaltic pump, a custom-built external heat exchanger, a chiller, biocompatible polyvinyl cellulose (PVC) tubing, and a control console. The CCS cools and circulates autologous blood externally and re-delivers cooled blood to the patient through a conventional catheter inserted directly into the organ at risk. Catheter configurations used included: a 7F guide catheter only, a 7F guide with a 0.038" wire inserted through the center and advanced 2 cm distal to the catheter distal tip, a 6F guide catheter only and a 6F guide with a 0.014" guidewire similarly inserted through the center. Using porcine blood, an in vitro test rig was used to measure the degree of hemolysis generation, defined as the percentage change in free hemoglobin, adjusted for total hemoglobin and hematocrit, between exiting and entering blood. The highest degree of hemolysis generation was 0.11±0.04%, based on the average behavior with a 6F catheter and a 0.014" guidewire configuration at a blood flow rate of approximately 130 mL/min. In terms of average percentage free hemoglobin exiting the system, based on total hemoglobin, the highest value measured was 0.17%±0.03%, using this 6F and 0.014" guidewire configuration. This result is significantly below the most stringent European guideline of 0.8% used for blood storage and transfusion. This study provides initial evidence showing hemolysis generation arising from the CoolGuide Cooling System is likely to be clinically insignificant. PMID:23047283

  17. From Blood Freud to Jury System: The Metamorphosis of Cherokee Law from 1750 to 1840.

    Science.gov (United States)

    Daniel, Michelle

    1987-01-01

    Examines the Cherokees' deliberate adoption of the laws of the white man, focusing on the blood feud--a retaliation system designed to deal with homicide. Discusses cultural bases of Cherokee law and factors influencing the change to a jury system and noted key events of the adoption period (1797 to 1840). (JHZ)

  18. Study for standardization of the lighting system in fruit sorting

    Science.gov (United States)

    Gomes, J. F. S.; Baldner, F. O.; Costa, P. B.; Guedes, M. B.; Oliveira, I. A. A.; Leta, F. R.

    2016-07-01

    Sorting is a very important step in the fruit processing. The attributes definition and characterization are important for both marketing and end user, making it necessary to establish regulations for classification and standardization in order to unify the language of the market and enabling a more efficient market and also increase consumer awareness. For this end, it is necessary to standardize the technical criteria that can change the perception of the product. Studies have been developed in order to standardize a methodology to determine the subclass of fruit ripening, evaluating the influence of different light sources in the subclass evaluation.

  19. Tunable laser diode system for noninvasive blood glucose measurements.

    Science.gov (United States)

    Olesberg, Jonathon T; Arnold, Mark A; Mermelstein, Carmen; Schmitz, Johannes; Wagner, Joachim

    2005-12-01

    Optical sensing of glucose would allow more frequent monitoring and tighter glucose control for people with diabetes. The key to a successful optical noninvasive measurement of glucose is the collection of an optical spectrum with a very high signal-to-noise ratio in a spectral region with significant glucose absorption. Unfortunately, the optical throughput of skin is low due to absorption and scattering. To overcome these difficulties, we have developed a high-brightness tunable laser system for measurements in the 2.0-2.5 microm wavelength range. The system is based on a 2.3 microm wavelength, strained quantum-well laser diode incorporating GaInAsSb wells and AlGaAsSb barrier and cladding layers. Wavelength control is provided by coupling the laser diode to an external cavity that includes an acousto-optic tunable filter. Tuning ranges of greater than 110 nm have been obtained. Because the tunable filter has no moving parts, scans can be completed very quickly, typically in less than 10 ms. We describe the performance of the present laser system and avenues for extending the tuning range beyond 400 nm. PMID:16390586

  20. 49 CFR 571.135 - Standard No. 135; Light vehicle brake systems.

    Science.gov (United States)

    2010-10-01

    ... Federal Motor Vehicle Safety Standards § 571.135 Standard No. 135; Light vehicle brake systems. S1. Scope... driving conditions. S3. Application. This standard applies to passenger cars manufactured on or after... Vehicle No. 105, Hydraulic Brake Systems. S4. Definitions. Adhesion utilization curves means...

  1. 49 CFR 571.124 - Standard No. 124; Accelerator control systems.

    Science.gov (United States)

    2010-10-01

    ... Federal Motor Vehicle Safety Standards § 571.124 Standard No. 124; Accelerator control systems. S1. Scope.... S3. Application. This standard applies to passenger cars, multi-purpose passenger vehicles, trucks, and buses. S4. Definitions. S4.1Driver-operated accelerator control system means all...

  2. Are Standards-Based Quality Systems a Threat to the Internationalization of Teaching and Learning?

    Science.gov (United States)

    Thompson-Whiteside, Scott

    2013-01-01

    This paper explores the current shift in Australia's higher education system moving to a more explicit, standards-based quality system and its potential impact on international partnerships in teaching and learning, particularly in Asia. The new Tertiary Education Quality and Standards Agency and the underlying Higher Education Standards Framework…

  3. System 80+{trademark} Standard Design: CESSAR design certification. Volume 9: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80{sup +}{trademark} Standard Design. This volume 9 discusses Electric Power and Auxiliary Systems.

  4. Analysis of the Status Quo of the Sericultural Standard System in China and Its Future

    Institute of Scientific and Technical Information of China (English)

    Ping; WU; Tao; CHENG; Long; LI; Xingjia; SHEN

    2014-01-01

    This paper summarizes and analyses the status quo of the sericultural standards system in China,and points out the characteristics and existed problems of sericultural standards in China. In addition,the future of the sericultural standards system is discussed.

  5. Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography

    Energy Technology Data Exchange (ETDEWEB)

    Lin Mingde; Marshall, Craig T.; Qi, Yi; Johnston, Samuel M.; Badea, Cristian T.; Piantadosi, Claude A.; Johnson, G. Allan [Department of Radiology, Center for In Vivo Microscopy and Department of Biomedical Engineering, Duke University Medical Center, Box 3302, Durham, North Carolina 27710 (United States); Division of Pulmonary and Critical Care Medicine and Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Box 3823, Durham, North Carolina 27710 (United States); Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, North Carolina 27710 (United States); Department of Radiology, Center for In Vivo Microscopy and Department of Biomedical Engineering, Duke University Medical Center, Box 3302, Durham, North Carolina 27710 (United States); Department of Radiology, Center for In Vivo Microscopy, Duke University Medical Center, Box 3302, Durham, North Carolina 27710 (United States); Division of Pulmonary and Critical Care Medicine and Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Box 3823, Durham, North Carolina 27710 (United States); Department of Radiology, Center for In Vivo Microscopy and Department of Biomedical Engineering, Duke University Medical Center, Box 3302, Durham, North Carolina 27710 (United States)

    2009-11-15

    Purpose: The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development. Among the major anatomic and physiologic indicators of disease progression and genetic or drug modification of responses are measurements of blood vessel caliber and flow. Moreover, cardiopulmonary blood flow is a critical indicator of gas exchange. Current methods of measuring cardiopulmonary blood flow suffer from some or all of the following limitations--they produce relative values, are limited to global measurements, do not provide vasculature visualization, are not able to measure acute changes, are invasive, or require euthanasia. Methods: In this study, high-spatial and high-temporal resolution x-ray digital subtraction angiography (DSA) was used to obtain vasculature visualization, quantitative blood flow in absolute metrics (ml/min instead of arbitrary units or velocity), and relative blood volume dynamics from discrete regions of interest on a pixel-by-pixel basis (100x100 {mu}m{sup 2}). Results: A series of calibrations linked the DSA flow measurements to standard physiological measurement using thermodilution and Fick's method for cardiac output (CO), which in eight anesthetized Fischer-344 rats was found to be 37.0{+-}5.1 ml/min. Phantom experiments were conducted to calibrate the radiographic density to vessel thickness, allowing a link of DSA cardiac output measurements to cardiopulmonary blood flow measurements in discrete regions of interest. The scaling factor linking relative DSA cardiac output measurements to the Fick's absolute measurements was found to be 18.90xCO{sub DSA}=CO{sub Fick}. Conclusions: This calibrated DSA approach allows repeated simultaneous visualization of vasculature and measurement of blood flow dynamics on a regional level in the living rat.

  6. Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography

    International Nuclear Information System (INIS)

    Purpose: The use of preclinical rodent models of disease continues to grow because these models help elucidate pathogenic mechanisms and provide robust test beds for drug development. Among the major anatomic and physiologic indicators of disease progression and genetic or drug modification of responses are measurements of blood vessel caliber and flow. Moreover, cardiopulmonary blood flow is a critical indicator of gas exchange. Current methods of measuring cardiopulmonary blood flow suffer from some or all of the following limitations--they produce relative values, are limited to global measurements, do not provide vasculature visualization, are not able to measure acute changes, are invasive, or require euthanasia. Methods: In this study, high-spatial and high-temporal resolution x-ray digital subtraction angiography (DSA) was used to obtain vasculature visualization, quantitative blood flow in absolute metrics (ml/min instead of arbitrary units or velocity), and relative blood volume dynamics from discrete regions of interest on a pixel-by-pixel basis (100x100 μm2). Results: A series of calibrations linked the DSA flow measurements to standard physiological measurement using thermodilution and Fick's method for cardiac output (CO), which in eight anesthetized Fischer-344 rats was found to be 37.0±5.1 ml/min. Phantom experiments were conducted to calibrate the radiographic density to vessel thickness, allowing a link of DSA cardiac output measurements to cardiopulmonary blood flow measurements in discrete regions of interest. The scaling factor linking relative DSA cardiac output measurements to the Fick's absolute measurements was found to be 18.90xCODSA=COFick. Conclusions: This calibrated DSA approach allows repeated simultaneous visualization of vasculature and measurement of blood flow dynamics on a regional level in the living rat.

  7. Continuous blood pressure monitoring in cirrhosis. Relations to splanchnic and systemic haemodynamics

    DEFF Research Database (Denmark)

    Møller, S; Christensen, E; Henriksen, Jens Henrik Sahl

    1997-01-01

    a high post-sinusoidal resistance, a low plasma volume, a short central circulation time, and the presence of ascites. In contrast, a low intra-arterial blood pressure was determined by a low serum sodium, a low haemoglobin, and a high cardiac output. Diuretic treatment did not influence this model......BACKGROUND/AIMS: Low arterial blood pressure is recognised as a distinctive factor in the hyperdynamic circulation in cirrhosis. 24-hour monitoring of the blood pressure and heart rate has recently revealed a reduced circadian variation with relation to liver function. However, associations with...... other clinical and haemodynamic characteristics have not been investigated and the aim of the present study was to identify splanchnic and systemic determinants of the 24-h blood pressure and heart rate in cirrhosis. METHODS: The variables were measured by an automatic ambulant device for monitoring...

  8. The development of a recruiting-drawing-inventory model for a community blood bank system.

    Science.gov (United States)

    Smackey, B M

    1975-01-01

    A community blood bank system is a multiorganizational program that is designed to supply the blood needs of a community. Participating in such a program are hospitals, a central blood bank, industrial donor groups, the American Red Cross, advisory committees, and the community at large. The underlying determinant of the community's success or failure with its blood program is the degree of cooperation among the various organizations. Intertwined with organizational considerations are the management problems associated with the operation of a responsive and efficient inventory control system. This paper reports on the development of a system for a community blood bank that is in its third year of operation. The system that has been developed can be operated manually by a part-time clerk. Details of the model include an integration of the donor scheduling function and the inventory control function. Simulated testing of the model has been conducted and full-scale implementation is awaiting the expansion of the known donor base.

  9. BioWatch - a wrist watch based signal acquisition system for physiological signals including blood pressure.

    Science.gov (United States)

    Thomas, Simi Susan; Nathan, Viswam; Chengzhi Zong; Akinbola, Ebunoluwa; Aroul, Antoine Lourdes Praveen; Philipose, Lijoy; Soundarapandian, Karthikeyan; Xiangrong Shi; Jafari, Roozbeh

    2014-01-01

    A wrist watch based system, which can measure electrocardiogram (ECG) and photoplethysmogram (PPG), is presented in this work. By using both ECG and PPG we also measure pulse transit time (PTT), which studies show to correlate well with blood pressure (BP). The system is also capable of monitoring heart rate using either ECG or PPG and can monitor blood oxygenation by easily replacing the PPG sensors with a different set. In this work, we investigate methods to train a fitting function to convert a PTT measurement to its corresponding systolic BP. We also validate measurements on different postures and show the value of calibrating the device for each posture. This system, called BioWatch, can potentially facilitate continuous and ubiquitous monitoring of ECG, PPG, heart rate, blood oxygenation and BP. PMID:25570444

  10. Implications of different residential lead standards on children's blood lead levels in France: predictions based on a national cross-sectional survey.

    Science.gov (United States)

    Oulhote, Youssef; LeTertre, Alain; Etchevers, Anne; Le Bot, Barbara; Lucas, Jean-Paul; Mandin, Corinne; Le Strat, Yann; Lanphear, Bruce; Glorennec, Philippe

    2013-11-01

    Despite the dramatic reductions in children's blood lead levels (BLLs), there is considerable evidence that low-level lead exposure is associated with intellectual deficits and behavioral problems, without apparent threshold. There are limited data, however, about the contribution of residential sources of lead to contemporary children's blood lead levels. The aim of this study is to calculate the contributions of residential sources of lead to assess the potential impact of setting new standards for lead levels in residential dust, soil and water. We enrolled 484 French children aged from 6 months to 6 years, and collected data on social, housing and individual characteristics. Lead concentrations in blood and environmental samples (water, soils, and dusts) were measured using inductively coupled plasma mass spectrometry. Data were analyzed using a multivariate generalized additive model accounting for the sampling design and the sampling weights. We found that exceedingly low concentrations of lead in dust, soil and water were significant predictors of children's BLLs, after adjustment for potential confounding variables. Lead-contaminated floor dust was the main source of lead in blood. BLLs (GM: 14μg/L) increased by 65%, 13%, 25%, and 5% when lead content in floor dust, loose soil, hard soil and water increased from their 25th percentile to their 95th percentile, respectively. We also observed that the steepest increase in BLLs occurred at the lowest levels of lead-contaminated floor dust, which indicates that lead contamination should be kept as low as possible. Impact of different possible standards on children's BLLs was also tabulated and indicated that unless standards are set low, they will only benefit a small proportion of children who have the highest exposures. PMID:23528234

  11. 49 CFR 571.105 - Standard No. 105; Hydraulic and electric brake systems.

    Science.gov (United States)

    2010-10-01

    ... systems. S1. Scope. This standard specifies requirements for hydraulic and electric service brake systems... braking performance under normal and emergency conditions. S3. Application. This standard applies to multi... are equipped with hydraulic or electric brake systems. S4. Definitions. Antilock brake system or...

  12. 40 CFR 60.482-10 - Standards: Closed vent systems and control devices.

    Science.gov (United States)

    2010-07-01

    ..., audible, or olfactory indications of leaks. (2) If the vapor collection system or closed vent system is... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standards: Closed vent systems and..., 2006 § 60.482-10 Standards: Closed vent systems and control devices. (a) Owners or operators of...

  13. [Multicenter evaluation of the reliability of five blood glucose monitoring systems].

    Science.gov (United States)

    Jday-Daly, Ismahen; Augereau-Vacher, Christine; De Curraize, Claire; Fonfrède, Michèle; Lefevre, Guillaume; Lacour, Bernard; Hennequin-Le Meur, Carole

    2011-01-01

    As part of a tender AP-HP Paris Hospitals, an assessment of the reliability record of five blood glucose monitoring systems (BGMSs) (Optium Xceed (Abbott), Contour TS (Bayer), One Touch Ultra (Lifescan), Stat Strip Xpress (Nova) and Accu Check (Roche) and an evaluation of their sensitivity to changes in hematocrit were conducted in 4 hospitals of Paris. In terms of inaccuracy, all BGMSs have submitted CV repetability under the limits of acceptability. One BGMS (Lifescan) presented a CV of reproducibility outside limit of acceptability (13.1%). The inaccuracy was measured by a comparison method on multiparameter analyser relative to the hexokinase method for two sites, the glucose oxidase for the two others. The coefficients of correlation varied from 0.8405 to 0.9303. However, according to both defined acceptability criteria (absolute value difference between the result acquired on analyzer and those determined with the BGMS), the percentage of results outside acceptability was above 20% for two BGMSs (Abbott and Lifescan). Similarly, a net effect of changes in hematocrit was observed on the results of those two BGMSs. BGMS Nova was the most reliable, because of the correction device for hematocrit and blank substractions owed to interferences. In terms of expertise, BGMSs Nova and Roche have been selected with the best analytical performance and practicability satisfactory. In the future, accreditation with standard NF/EN 22870 requested for point of care testing, will require a close collaboration between biologists and clinicians to establish a system of strict quality control to detect deviations of these BGMSs. PMID:21463996

  14. ETV Program Report: Coatings for Wastewater Collection Systems - Standard Cement Materials, Epoxy Coating 4553

    Science.gov (United States)

    The Standard Cement Materials, Inc. Standard Epoxy Coating 4553™ (SEC 4553) epoxy coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Ma...

  15. Pig brain stereotaxic standard space: mapping of cerebral blood flow normative values and effect of MPTP-lesioning

    DEFF Research Database (Denmark)

    Andersen, F; Watanabe, Hideaki; Bjarkam, Carsten;

    2005-01-01

    of minipig brain, we calculated cerebral blood flow (CBF) maps from normal minipigs and from minipigs with a syndrome of parkisonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-poisoning. These maps were transformed from the native space into the common stereotaxic space. After global...

  16. Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space

    Science.gov (United States)

    Hallgren, Emma; Migeotte, Pierre-François; Kornilova, Ludmila; Delière, Quentin; Fransen, Erik; Glukhikh, Dmitrii; Moore, Steven T.; Clément, Gilles; Diedrich, André; MacDougall, Hamish; Wuyts, Floris L.

    2015-01-01

    It is a challenge for the human body to maintain stable blood pressure while standing. The body’s failure to do so can lead to dizziness or even fainting. For decades it has been postulated that the vestibular organ can prevent a drop in pressure during a position change – supposedly mediated by reflexes to the cardiovascular system. We show – for the first time – a significant correlation between decreased functionality of the vestibular otolith system and a decrease in the mean arterial pressure when a person stands up. Until now, no experiments on Earth could selectively suppress both otolith systems; astronauts returning from space are a unique group of subjects in this regard. Their otolith systems are being temporarily disturbed and at the same time they often suffer from blood pressure instability. In our study, we observed the functioning of both the otolith and the cardiovascular system of the astronauts before and after spaceflight. Our finding indicates that an intact otolith system plays an important role in preventing blood pressure instability during orthostatic challenges. Our finding not only has important implications for human space exploration; they may also improve the treatment of unstable blood pressure here on Earth. PMID:26671177

  17. Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

    Directory of Open Access Journals (Sweden)

    Ravi Kant Upadhyay

    2014-01-01

    Full Text Available Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs, radiopharmaceuticals, proteins, immunoglobulins, and chimeric peptides to the target sites in deep tissue locations inside tumor sites of brain has been explained. In addition, therapeutic applications of various types of nanoparticles such as chitosan based nanomers, dendrimers, carbon nanotubes, niosomes, beta cyclodextrin carriers, cholesterol mediated cationic solid lipid nanoparticles, colloidal drug carriers, liposomes, and micelles have been discussed with their recent advancements. Emphasis has been given on the need of physiological and therapeutic optimization of existing drug delivery methods and their carriers to deliver therapeutic amount of drug into the brain for treatment of various neurological diseases and disorders. Further, strong recommendations are being made to develop nanosized drug carriers/vehicles and noninvasive therapeutic alternatives of conventional methods for better therapeutics of CNS related diseases. Hence, there is an urgent need to design nontoxic biocompatible drugs and develop noninvasive delivery methods to check posttreatment clinical fatalities in neuropatients which occur due to existing highly toxic invasive drugs and treatment methods.

  18. Overview of the South African mine health and safety standardization and regulation systems

    Institute of Scientific and Technical Information of China (English)

    LI Zhong-xue; LI Jia-jie; LI Cui-ping; LIU Shuang-yue

    2008-01-01

    Outlined the South African mine health and safety regulatory framework, including the roles of government, tripartite council, service agencies, mine enterprises,rescue stations and workers unions, analyzed the institutional structures of South African mine health and safety standardization, including the South African standard and specification systems and standard development processes, and characterized the South African mine health and safety standardization and regulation systems. Intended to provide some suggestions for the transformation and improvement of mine health and safety standardization and regulation systems in China or in similar situations.

  19. A systems-based approach to managing blood pressure in children following kidney transplantation.

    Science.gov (United States)

    Hooper, David K; Mitsnefes, Mark

    2016-10-01

    Hypertension is one of the most common and well-known complications following kidney transplantation in children. Yet, despite numerous available therapies many pediatric kidney transplant recipients continue to have poorly controlled blood pressure, suggesting that traditional approaches to blood pressure management in this population might be inadequate. Over the last two decades, the Chronic Care Model has been developed to improve chronic illness outcomes through delivery system design and clinical information systems that support patient self-management and provider decision-making. In this educational review we discuss key elements of managing blood pressure following pediatric kidney transplantation and suggest ways that they may be reliably implemented into clinical practice using principles from the Chronic Care Model. PMID:26482251

  20. Stochastic and Optimization Programming for Blood Glucose & Insulin Regulatory Systems of Type-2 Diabetes

    Directory of Open Access Journals (Sweden)

    P. Tirupathi Rao

    2012-11-01

    Full Text Available In this paper a stochastic modeling and optimization problem is developed for blood glucose and insulin regulatory system suitable for management of type-2 diabetes patients. The rates of arrival and consumption of glucose and insulin in the blood are assumed as Poisson parameters and developed a model through stochastic processes. A stochastic programming problem for maintaining the optimized glucose and insulin levels of the blood is developed. An objective function for maximizing the energy release subject to the constraints on the consumption of glucose is formulated. Sensitivity analysis was carried out and observed the model behaviour through influencing parameters. Enhancing the developed programming problem as desk top automation system will make this work more accessible to the decision makers of Health care industry.

  1. Development of a 24-locus multiplex system to incorporate the core loci in the Combined DNA Index System (CODIS) and the European Standard Set (ESS).

    Science.gov (United States)

    Guo, Fei; Shen, Hongying; Tian, Huaizhou; Jin, Ping; Jiang, Xianhua

    2014-01-01

    The 24-locus multiplex system allows co-amplification and fluorescent detection of 24 loci (23 STR loci and Amelogenin), including STR loci in the Combined DNA Index System (CODIS) and the ESS (European Standard Set) as well as five additional loci (D2S1338, D6S1043, D19S433, Penta D and Penta E) commonly used in commercial kits. It facilitates data sharing and minimizes adventitious matches within national or between international DNA databases. Additionally, the system can amplify directly from blood and buccal samples spotted on filter paper and swabs and reduce the cycling time to less than one hour and a half. Primers, internal size standard, allelic ladders and matrix standard set were designed and created in-house with a design strategy to work in this multiplex. Developmental validation experiments followed the Scientific Working Group on DNA Analysis Methods (SWGDAM) and the Chinese National Standard (GA/T815-2009) guidelines. The system was evaluated by species specificity, sensitivity, stability, precision and accuracy, case-type samples, population, mixture and PCR-based studies. The results demonstrate that the 24-locus multiplex system is a robust and reliable identification assay as required for forensic DNA typing and databasing.

  2. 15 CFR 14.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Standards for financial management... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management §...

  3. 28 CFR 70.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Standards for financial management... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS (INCLUDING SUBAWARDS) WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Financial and Program Management §...

  4. [Design and implementation of medical instrument standard information retrieval system based on APS.NET].

    Science.gov (United States)

    Yu, Kaijun

    2010-07-01

    This paper Analys the design goals of Medical Instrumentation standard information retrieval system. Based on the B /S structure,we established a medical instrumentation standard retrieval system with ASP.NET C # programming language, IIS f Web server, SQL Server 2000 database, in the. NET environment. The paper also Introduces the system structure, retrieval system modules, system development environment and detailed design of the system. PMID:21033116

  5. A Comparative Study of Blood Glucose Measurements Using Glucometer Readings and the Standard Method in the Diagnosis of Neonatal Hypoglycemia

    OpenAIRE

    Mohammad Torkaman; Gholamreza Bagheri; Ahmad Ahmadi; Amin Saburi

    2016-01-01

    Background: Hypoglycemia is one of the most common neonatal disorders, associated with severe complications. There has been a great deal of controversy regarding the definition and screening of hypoglycemia. Therefore, in this study, we aimed to determine a cut-off value for blood glucose level in glucometer readings. Methods: This cross-sectional study was conducted on 238 newborns at risk of hypoglycemia, admitted to Baqiyatallah Hospital of Tehran, Iran in 2012; the subjects were selected ...

  6. An intelligent system for continuous blood pressure monitoring on remote multi-patients in real time

    CERN Document Server

    Marani, Roberto

    2012-01-01

    In this paper we present an electronic system to perform a non-invasive measurement of the blood pressure based on the oscillometric method, which does not suffer from the limitations of the well-known auscultatory one. Moreover the proposed system is able to evaluate both the systolic and diastolic blood pressure values and makes use of a microcontroller and a Sallen-Key active filter. With reference to other similar devices, a great improvement of our measurement system is achieved since it performs the transmission of the systolic and diastolic pressure values to a remote computer. This aspect is very important when the simultaneous monitoring of multi-patients is required. The proposed system, prototyped and tested at the Electron Devices Laboratory (Electrical and Information Engineering Department) of Polytechnic University of Bari, Italy, is characterized by originality, by plainness of use and by a very high level of automation (so called intelligent system).

  7. Non-association between anti-Toxoplasma gondii antibodies and ABO blood group system

    Directory of Open Access Journals (Sweden)

    ACF Rodrigues

    2011-01-01

    Full Text Available Toxoplasma gondii infects humans through the gastrointestinal tract (GIT, which elicits humoral immune response with specific antibodies. The expression of the ABO blood group glycoconjugates also occurs in this same system and may influence the human susceptibility of infection by T. gondii. The aim of the present study was to investigate the association between ABO blood group phenotypes and the presence of anti-T. gondii antibodies. Data - including age, results of serology tests for T. gondii infection and ABO blood group phenotypes - were assembled from the medical records of 1,006 pregnant women attended in the Base Hospital of the Medical School of São José do Rio Preto, Brazil, between 2001 and 2004. The chi-square test was used to compare the results with the level of significance set at 5%. Of the studied cases, 64.1% (645/1006 and 35.9% (391/1006 presented respectively positive and negative serology tests for anti-T. gondii antibodies. The mean age of those who tested positive was higher than those with negative serology tests (p = 0.0004. The frequencies of ABO blood group phenotypes were similar in those with and without anti-T. gondii antibodies (p = 0.35. In conclusion, the ABO blood group system is not associated with the presence or absence of anti-T. gondii antibodies.

  8. 49 CFR 571.104 - Standard No. 104; Windshield wiping and washing systems.

    Science.gov (United States)

    2010-10-01

    ... systems. S1. Scope. This standard specifies requirements for windshield wiping and washing systems. S2. Application. This standard applies to passenger cars, multipurpose passenger vehicles, trucks, and buses. S3... Driver's Eye Range,” November 1965. S4. Requirements. S4.1Windshield wiping system. Each vehicle...

  9. 36 CFR 64.12 - Standards for grantee financial management systems.

    Science.gov (United States)

    2010-07-01

    ... financial management systems. 64.12 Section 64.12 Parks, Forests, and Public Property NATIONAL PARK SERVICE... RIGHTS-OF-WAY § 64.12 Standards for grantee financial management systems. The grantees' Financial Management Systems shall meet the minimum standards set forth in OMB Circular A-102, Attachment G....

  10. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Science.gov (United States)

    2010-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be...) Document OG-300-93, Operating Guidelines and Minimum Standards for Certifying Solar Water Heating...

  11. 78 FR 73112 - Monitoring System Conditions-Transmission Operations Reliability Standards; Interconnection...

    Science.gov (United States)

    2013-12-05

    ...); TOP-005-2a (Operational Reliability Information); TOP-006-2 (Monitoring System Conditions); TOP-007-0... Reliability Standards ``address the important reliability goal of ensuring that the transmission system is... System Operating Limits (SOLs).\\5\\ The provisions in the proposed TOP Reliability Standards that...

  12. European Group for Blood and Marrow Transplantation Centers with FACT-JACIE Accreditation Have Significantly Better Compliance with Related Donor Care Standards.

    Science.gov (United States)

    Anthias, Chloe; O'Donnell, Paul V; Kiefer, Deidre M; Yared, Jean; Norkin, Maxim; Anderlini, Paolo; Savani, Bipin N; Diaz, Miguel A; Bitan, Menachem; Halter, Joerg P; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; Shaw, Bronwen E

    2016-03-01

    Previous studies have identified healthcare practices that may place undue pressure on related donors (RDs) of hematopoietic cell products and an increase in serious adverse events associated with morbidities in this population. As a result, specific requirements to safeguard RD health have been introduced to Foundation for the Accreditation of Cellular Therapy/The Joint Accreditation Committee ISCT and EBMT (FACT-JACIE) Standards, but the impact of accreditation on RD care has not previously been evaluated. A survey of transplant program directors of European Group for Blood and Marrow Transplantation member centers was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to test the hypothesis that RD care in FACT-JACIE accredited centers is more closely aligned with international consensus donor care recommendations than RD care delivered in centers without accreditation. Responses were received from 39% of 304 centers. Our results show that practice in accredited centers was much closer to recommended standards as compared with nonaccredited centers. Specifically, a higher percentage of accredited centers use eligibility criteria to assess RDs (93% versus 78%; P = .02), and a lower percentage have a single physician simultaneously responsible for an RD and their recipient (14% versus 35%; P = .008). In contrast, where regulatory standards do not exist, both accredited and nonaccredited centers fell short of accepted best practice. These results raise concerns that despite improvements in care, current practice can place undue pressure on donors and may increase the risk of donation-associated adverse events. We recommend measures to address these issues through enhancement of regulatory standards as well as national initiatives to standardize RD care.

  13. The Persistence of Misconceptions about the Human Blood Circulatory System among Students in Different Grade Levels

    Science.gov (United States)

    Ozgur, Sami

    2013-01-01

    In this paper, it is aimed to investigate the persistence of misconceptions in the topic of the human blood circulatory system among students in different grade levels. For this reason, after discussions with biology educators, two tests consisting of open-ended questions were developed by the researcher and administered to students in four…

  14. Advances of blood oxygen-level dependent MRI in muscular system

    International Nuclear Information System (INIS)

    BOLD-fMRI has been applied to muscular system to observe muscular pathophysiological change after performing a task and show the characteristics of muscle perfusion. This paper mainly introduces the scanning sequence, common tasking methods, such as cuff compression, excise, oxygen and drug, etc. It also introduces clinical study of perfusion reserve of muscular tissue with abnormal blood vessels. (authors)

  15. The immune system mediates blood-brain barrier damage; Possible implications for pathophysiology of neuropsychiatric illnesses

    NARCIS (Netherlands)

    VanderWerf, YD; DeJongste, MJL; terHorst, GJ

    1995-01-01

    The immune system mediates blood-brain barrier damage; possible implications for pathophysiology of neuropsychiatric illnesses. In this investigation the effects of immune activation on the brain are characterized In order to study this, we used a model for chronic immune activation, the myocardial

  16. The standards for skill assessment of operational marine forecast system

    Institute of Scientific and Technical Information of China (English)

    ZHANG Aijun; FAN Wenjing; JI Fengying

    2007-01-01

    To support navigational and environmental applications in coastal waters, marine operational forecast models must be developed and implemented. A forecast model must guarantee that it is scientifically sound and practically robust for performance and must meet or excel all target frequencies or durations before being released to the public. This paper discusses the standard policies and procedures for evaluation of operational marine forecast models. The primary variables to be evaluated are water levels, currents and water density (water temperature and salinity).

  17. 49 CFR 571.303 - Standard No. 303; Fuel system integrity of compressed natural gas vehicles.

    Science.gov (United States)

    2010-10-01

    ... are those specified in S8.2 of Standard No. 208, 49 CFR 571.208. S7.3Rear moving barrier test conditions. The rear moving barrier test conditions are those specified in S8.2 of Standard No. 208, 49 CFR... system integrity of compressed natural gas vehicles. S1. Scope. This standard specifies requirements...

  18. 49 CFR 571.113 - Standard No. 113; Hood latch system.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.113 Standard No. 113; Hood latch system. S1. Purpose and scope.... Application. This standard applies to passenger cars, multipurpose passenger vehicles, trucks, and buses. S3... engine, luggage, storage, or battery compartment. S4. Requirements. S4.1Each hood must be provided with...

  19. 49 CFR 571.122 - Standard No. 122; Motorcycle brake systems.

    Science.gov (United States)

    2010-10-01

    ... conditions. S3. Application. This standard applies to motorcycles. S4. Definitions. Braking interval means... Federal Motor Vehicle Safety Standards § 571.122 Standard No. 122; Motorcycle brake systems. S1. Scope... the sequence specified in S7. Corresponding test procedures of S7 are indicated in parentheses. If...

  20. Standardization of education as essential to the development of regional educational systems

    Directory of Open Access Journals (Sweden)

    Shevchuk Andrey

    2013-01-01

    Full Text Available The problematic aspects of the current educational standards in Ukraine as important legal instruments of regional educational systems were viewed. The regulated areas of education standards in Ukraine and the traditional approach based on the identified areas of their innovative changes where described. The main directions of innovation education standards depending on their subject focus where systemised.

  1. System 80+{trademark} Standard Design: CESSAR design certification. Volume 17: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describes the Combustion Engineering, Inc. System 80+{trademark} Standard Design. This Volume 17 provides Appendix A of this report, closure of unresolved and Genetic Safety Issues.

  2. System 80+{trademark} Standard Design: CESSAR design certification. Volume 11: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80{sup +}{trademark} Standard Design. This volume 11 discusses Radiation Protection, Conduct of Operations, and the Initial Test Program.

  3. System 80+{trademark} Standard Design: CESSAR design certification. Volume 6: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report - Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These documents describe the Combustion Engineering, Inc. System 80+{sup TM} Standard Design. This report, Volume 6, in conjunction with Volume 7, provides a description of engineered safety features.

  4. System 80+{trademark} Standard Design: CESSAR design certification. Volume 16: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report - Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80+{trademark} Standard Design. This Volume 16 details the application of Human Factors Engineering in the design process.

  5. System 80+{trademark} Standard Design: CESSAR design certification. Volume 4: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report - Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These documents describe the Combustion Engineering, Inc. System 80+{sup TM} Standard Design. This report, Volume 4, provides a description of the reactor, reactor internals, fuel assemblies, and associated design requirements.

  6. System 80+{trademark} Standard Design: CESSAR design certification. Volume 12: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80{sup +}{trademark} Standard Design. This volume 12, along with volume 13, provides accident analyses.

  7. System 80+{trademark} Standard Design: CESSAR design certification. Volume 1: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report - Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These Volumes, describe the Combustion Engineering, Inc. System 80+{sup TM} Standard Design. This document, Volume 1, provides an introduction and general description of plant and site envelope characteristics.

  8. System 80+{trademark} Standard Design: CESSAR design certification. Volume 18: Amendment I

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-21

    This report, entitled Combustion Engineering Standard Safety Analysis Report -- Design Certification (CESSAR-DC), has been prepared in support of the industry effort to standardize nuclear plant designs. These volumes describe the Combustion Engineering, Inc. System 80+{trademark} Standard Design. This Volume 18 provides Appendix B, Probabilistic Risk Assessment.

  9. Public Service System of the College Students' Physical Health Standards

    OpenAIRE

    Song Ailing; Chen Kai; Liu Xu

    2013-01-01

    This study optimizes the “college students’ physical health standard” assessment system based on the theory of human physiology. Under the use of “TOMCAT + JSP + SERVLET” computer technology, the physical health assessment and exercise prescription guidance system are established based on the theory. To use the dynamic pages technology and database technology, an interactive and personalized web platform is designed, so that the system has a public service function. The public service system ...

  10. Role of histaminergic system in blood-brain barrier dysfunction associated with neurological disorders.

    Science.gov (United States)

    Bañuelos-Cabrera, Ivette; Valle-Dorado, María Guadalupe; Aldana, Blanca Irene; Orozco-Suárez, Sandra Adela; Rocha, Luisa

    2014-11-01

    Blood-brain barrier (BBB) disruption has been associated with several acute and chronic brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy. This represents a critical situation because damaged integrity of the BBB is related to the influx of immune mediators, plasma proteins and other outside elements from blood to the central nervous system (CNS) that may trigger a cascade of events that leads to neuroinflammation. In this review, evidence that mast cells and the release of factors such as histamine play an important role in the neuroinflammatory process associated with brain disorders such as Alzheimer's disease, Parkinson's disease and epilepsy is presented.

  11. Modeling of human colonic blood flow for a novel artificial anal sphincter system

    Institute of Scientific and Technical Information of China (English)

    Peng ZAN; Guo-zheng YAN; Hua LIU

    2008-01-01

    A novel artificial anal sphincter system has been developed to simulate the normal physiology of the human anorectum. With the goal of engineering a safe and reliable device, the model of human colonic blood flow has been built and the relationship between the colonic blood flow rate and the operating occlusion pressure of the anorectum is achieved. The tissue ischemia is analyzed based on constitutive relations for human anorectum. The results suggest that at the planned operating occlusion pressure of less than 4 kPa the artificial anal sphincter should not risk the vaseularity of the human colon.

  12. A real time, wearable ECG and continous blood pressure monitoring system for first responders.

    Science.gov (United States)

    Ribeiro, David M D; Colunas, Marcio F M; Marques, Fabio A Ferreira; Fernandes, Jose M; Cunha, Joao P Silva

    2011-01-01

    The study of stress and fatigue among First Responders is a major step in mitigating this public health problem. Blood pressure, heart rate variability and fatigue related arrhythmia are three of the main "windows" to study stress and fatigue. In this paper we present a wearable medical device, capable of acquiring an electrocardiogram and estimating blood pressure in real time, through a pulse wave transit time approach. The system is based on an existent certified wearable medical device called "Vital Jacket" and is aimed to become a tool to allow cardiologists in studying stress and fatigue among first response professionals. PMID:22255923

  13. Standards and guidelines applicable for the validation of programmable automation systems

    International Nuclear Information System (INIS)

    The validation of programmable automation system for an application important to safety in a nuclear power plant requires a comprehensive view about the system quality and reliability. One central point is to get assured that proper international guidelines and standards have been followed in the design, construction and maintenance of the system. The study was directed to locate international standards and guidelines which can support the validation of programmable systems and to evaluate their applicability for the validation of systems on different levels of requirement during their life cycle. The publication reviews the most important international standards (IAEA, ISO, IEC, IEEE) and their basic principles both for system and application program. Several nuclear standards, which have drawn the main attention, and some general programmable automation standards have been examined. In addition one practical automation system has been examined in order to find essential questions. Based on these studies a set of important items for the qualification have been identified

  14. Safety evaluation report related to the preliminary design of the Standard Reference System, RESAR-414

    International Nuclear Information System (INIS)

    The safety evaluation for the Westinghouse Standard Reactor includes information on general reactor characteristics; design criteria for systems and components; reactor coolant system; engineered safety systems; instrumentation and controls; electric power systems; auxiliary systems; steam and power conversion system; radioactive waste management; radiation protection; conduct of operations; accident analyses; and quality assurance

  15. Second-meal effects of pulses on blood glucose and subjective appetite following a standardized meal 2 h later.

    Science.gov (United States)

    Mollard, Rebecca C; Wong, Christina L; Luhovyy, Bohdan L; Cho, France; Anderson, G Harvey

    2014-07-01

    This study investigated whether pulses (chickpeas, yellow peas, navy beans, lentils) have an effect on blood glucose (BG) and appetite following a fixed-size meal 2 h later. Over the following 2 h, all pulses lowered BG area under the curve (AUC) and lentils reduced appetite AUC compared with white bread (p < 0.05). Following the meal, BG was lower after lentils and chickpeas at 150 and 165 min, and AUC was lower after lentils compared with white bread (p < 0.05). PMID:24797207

  16. Blood Transfusion (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Blood Transfusions KidsHealth > For Parents > Blood Transfusions Print A ... and help put your child at ease. About Blood Transfusions Blood is like the body's transportation system. ...

  17. A 133-xenon inhalation system for cerebral blood-flow measurements in ventilated premature babies

    International Nuclear Information System (INIS)

    We constructed a Xenon-133 inhalation and trapping system in order to measure cerebral blood flow of ventilated premature babies by means of the noninvasive 133Xe clearance method. The completely lead-shielded inhalation device is a closed system driven by the baby's own respirator and can thus be safely used at the patients bedside in the intensive care unit. Reproducible proximal airway concentrations of 133Xe (with or without leaks around the endotracheal tube) were obtained by in vitro simulation. (orig.)

  18. Immunophenotyping of Lymphocyte T and B in the Peripheral Blood of Systemic Lupus Erythematosus

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The immunophenotyping expression levels of lymphocyte in the peripheral blood from 21 patients with active systemic lupus erythematosus (SLE) were analyzed by using the immunofluorescence labeling-flow cytometry technique to investigate the immunophenotyping expression of lymphocytes T and B in the peripheral blood of active SLE patients and its clinical value. It was showed that, compared with normal controls, the expression of CD+3, CD+4 and the ratio of CD+4/CD+8 in the peripheral blood of these patients were decreased (P<0.01), while the expression of CD+8, CD+20 was significantly increased (P<0.01). It was suggested that both T and B cells in patients with active SLE involved in immunoregulation, were activated. The abnormal expression of lymphocyte immunophenotyping could influence the immune reaction in SLE patients, which might be one of the important pathogenesis factors in SLE.

  19. Standardization of neonatal T4 by RIA using blood droplets on filter paper for the detection of neonatal hypothyroidism

    International Nuclear Information System (INIS)

    The aim of this work was to assist the national programme for the prevention of endemic goitre by devising a reliable low-cost technique for the detection of neonatal hypothyroidism. RIA determinations of T4 using bulk reagents were standardized by the second antibody method. 4 refs, 4 figs

  20. Assessment of Offshore Wind System Design, Safety, and Operation Standards

    Energy Technology Data Exchange (ETDEWEB)

    Sirnivas, S.; Musial, W.; Bailey, B.; Filippelli, M.

    2014-01-01

    This report is a deliverable for a project sponsored by the U.S. Department of Energy (DOE) entitled National Offshore Wind Energy Resource and Design Data Campaign -- Analysis and Collaboration (contract number DE-EE0005372; prime contractor -- AWS Truepower). The project objective is to supplement, facilitate, and enhance ongoing multiagency efforts to develop an integrated national offshore wind energy data network. The results of this initiative are intended to 1) produce a comprehensive definition of relevant met-ocean resource assets and needs and design standards, and 2) provide a basis for recommendations for meeting offshore wind energy industry data and design certification requirements.

  1. A Study on Standards System of Chinese Environmental Labeling Program

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Implementing Outlines for the Chinese Environmental Labeling Program By awarding certificates and labels to related manufacturers in accordance with certain environmental labeling standards, environmental labeling,also called "Green Label"or "Eco-label", certifies via governmental departments or public and private organizations that the whole process of producing,using, recalling and disposing of manufacturers'products is in compliance with certain environmental requirements. Many countries are establishing and promoting environmental labeling plans. Environmental labeling, as an important promotion means for prevention and control of pollution in a market-oriented manner, is being extended and developed constantly across the world.

  2. Novel optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation

    Science.gov (United States)

    Petrov, Yuriy; Petrov, Irene Y.; Prough, Donald S.; Esenaliev, Rinat O.

    2012-02-01

    Traumatic brain injury (TBI) and spinal cord injury are a major cause of death for individuals under 50 years of age. In the USA alone, 150,000 patients per year suffer moderate or severe TBI. Moreover, TBI is a major cause of combatrelated death. Monitoring of cerebral venous blood oxygenation is critically important for management of TBI patients because cerebral venous blood oxygenation below 50% results in death or severe neurologic complications. At present, there is no technique for noninvasive, accurate monitoring of this clinically important variable. We proposed to use optoacoustic technique for noninvasive monitoring of cerebral venous blood oxygenation by probing cerebral veins such as the superior sagittal sinus (SSS) and validated it in animal studies. In this work, we developed a novel, medical grade optoacoustic system for continuous, real-time cerebral venous blood oxygenation monitoring and tested it in human subjects at normal conditions and during hyperventilation to simulate changes that may occur in patients with TBI. We designed and built a highly-sensitive optoacoustic probe for SSS signal detection. Continuous measurements were performed in the near infrared spectral range and the SSS oxygenation absolute values were automatically calculated in real time using a special algorithm developed by our group. Continuous measurements performed at normal conditions and during hyperventilation demonstrated that hyperventilation resulted in approximately 12% decrease of cerebral venous blood oxygenation.

  3. Developing standardized web portals in java with the Liferay system

    OpenAIRE

    Pušnik, Marjan

    2009-01-01

    In recent years, there is a growing number of web portals that enable the management of online content and documents. These are so called web content management systems(WCMS). WCMS systems are today developed for the most software platforms such as. . NET, PHP, Python and Java. . NET is a software framework that is accessible on most Microsoft Windows operating systems and is used to make applications for the Microsoft Windows platform. PHP Scripting Language is designed for generating dynami...

  4. Standard practice for classification of computed radiology systems

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2005-01-01

    1.1 This practice describes the evaluation and classification of a computed radiography (CR) system, a particular phosphor imaging plate (IP), system scanner and software, in combination with specified metal screens for industrial radiography. It is intended to ensure that the evaluation of image quality, as far as this is influenced by the scanner/IP system, meets the needs of users. 1.2 The practice defines system tests to be used to classify the systems of different suppliers and make them comparable for users. 1.3 The CR system performance is described by signal and noise parameters. For film systems, the signal is represented by gradient and the noise by granularity. The signal-to-noise ratio is normalized by the basic spatial resolution of the system and is part of classification. The normalization is given by the scanning aperture of 100 µm diameter for the micro-photometer, which is defined in Test Method E1815 for film system classification. This practice describes how the parameters shall be meas...

  5. Alpha-amylase activity in blood increases after pharmacological, but not psychological, activation of the adrenergic system

    OpenAIRE

    Nater, Urs M.; Roberto La Marca; Katja Erni; Ulrike Ehlert

    2015-01-01

    BACKGROUND & AIM: Alpha-amylase in both blood and saliva has been used as a diagnostic parameter. While studies examining alpha-amylase activity in saliva have shown that it is sensitive to physiological and psychological challenge of the adrenergic system, no challenge studies have attempted to elucidate the role of the adrenergic system in alpha-amylase activity in blood. We set out to examine the impact of psychological and pharmacological challenge on alpha-amylase in blood in two separat...

  6. Nantenna for Standard 1550 nm Optical Communication Systems

    Directory of Open Access Journals (Sweden)

    Waleed Tariq Sethi

    2016-01-01

    Full Text Available Nanoscale transmission and reception technologies will play a vital role and be part of the next generation communication networks. This applies for all application fields including imaging, health, biosensing, civilian, and military communications. The detection of light frequency using nanooptical antennas may possibly become a good competitor to the semiconductor based photodetector because of the simplicity of integration, cost, and inherent capability to detect the phase and amplitude instead of power only. In this paper, authors propose simulated design of a hexagonal dielectric loaded nantenna (HDLN and explore its potential benefits at the standard optical C-band (1550 nm. The proposed nantenna consists of “Ag-SiO2-Ag” structure, consisting of “Si” hexagonal dielectric with equal lengths fed by “Ag” nanostrip transmission line. The simulated nantenna achieves an impedance bandwidth of 3.7% (190.9 THz–198.1 THz and a directivity of 8.6 dBi, at a center frequency of 193.5 THz, covering most of the ITU-T standard optical transmission window (C-band. The hexagonal dielectric nantenna produces HE20δ modes and the wave propagation is found to be end-fire. The efficiency of the nantenna is proven via numerical expressions, thus making the proposed design viable for nanonetwork communications.

  7. Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran in blood donors of south Gujarat, India

    Directory of Open Access Journals (Sweden)

    Manoj A Kahar

    2014-01-01

    Full Text Available Background: This is the first study on phenotype frequencies of various blood group systems in blood donors of south Gujarat, India using conventional tube technique. Material and Methods: A total of 115 "O" blood group donors from three different blood banks of south Gujarat were typed for D, C, c, E, e, K, Jk a , Le a , Le b , P 1 , M, and N antigens using monoclonal antisera and k, Kp a , Kp b , Fy a ,Fy b , Jk b , S,s, Lu a , and Lu b antigens were typed using polyclonal antisera employing Indirect Antiglobulin Test. Antigens and phenotype frequencies were expressed as percentages. Results: From the 115 blood donor samples used for extended antigen typing in the Rh system, e antigen was found in 100% donors, followed by D [84.35%], C [81.74%], c [56.32%], and E [21.74%] with DCe/DCe (R 1 R 1 , 40.87% as the most common phenotype. k was found to be positive in 100% of donors and no K+k- phenotype was found in Kell system. For Kidd and Duffy blood group system, Jk(a+b+ and Fy(a-b- were the most common phenotypes with frequency of 52.17% and 48.69%, respectively. In the MNS system, 39.13% donors were typed as M+N+, 37.39% as M+N-, and 23.48% as M-N+. S+s+ was found in 24.35% of donors, S+s- in 8.69%, and S-s+ as the commonest amongst donors with 66.96%. No Lu(a+b+ or Lu(a+b- phenotypes were detected in 115 donors typed for Lutheran antigens. A rare Lu(a-b- phenotype was found in 2.61% donors. Conclusion: Data base for antigen frequency of various blood group systems in local donors help provide antigen negative compatible blood units to patients with multiple antibodies in order to formulate in-house red cells for antibody detection and identification and for preparing donor registry for rare blood groups.

  8. China to Develop Rules for Composing a Standards System for Enterprise Energy Efficiency

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ April 11, 2007, SAC announced a survey on a standards system for enterprise energy efficiency. According to the announcement, "Rules for the Composing of a Standards System for Enterprise Energy Efficiency" shall be developed based on the results of the survey. The rules are designed to better manage energy efficiency through standards and to give advice to companies on energy efficiency. In this way, China will be able to assist companies in energy efficiency on a more professional, strict, and comprehensive basis.

  9. High Efficiency Three Phase Resonant Conversion for Standardized Architecture Power System Applications Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A low-cost, standardized-architecture power system is proposed for NASA electric propulsion (EP) applications. Three approaches are combined to develop a system...

  10. 76 FR 55829 - Federal Motor Vehicle Safety Standards; Electronic Stability Control Systems

    Science.gov (United States)

    2011-09-09

    ... Standards; Electronic Stability Control Systems AGENCY: National Highway Traffic Safety Administration... electronic stability control systems. In that final rule, the agency stated that it had previously fulfilled... technical regulation for electronic stability control and had adopted the regulation to the...

  11. Multicenter Evaluation of a Semiautomated, Standardized Assay for Detection of Hepatitis B Virus DNA in Blood Donations

    OpenAIRE

    Romanò, Luisa; Velati, Claudio; Baruffi, Lorella; Fomiatti, Laura; Colucci, Giuseppe; Zanetti, Alessandro R.

    2005-01-01

    We evaluated the COBAS Ampliscreen hepatitis B virus (HBV) test using standards, seroconversion panels, consecutive donations, and samples from patients with abnormal alanine aminotransferase and chronic hepatitis C. Specificity was 100% and sensitivity was 20 IU/ml. In seroconversion panels, HBV DNA was detected up to 4 to 18 days before HBsAg, suggesting that this assay is useful in shortening the infectious window phase.

  12. Technology battles for complex systems: The influence of networks and standard flexibility

    NARCIS (Netherlands)

    Van der Kaa, G.

    2012-01-01

    Most literature on standard selection focuses on compatibility standards for single products or large but single systems that are developing, such as the internet or a telecommunications network. In this study, we focus on systems that connect multiple existing subsystems and new subsystems to form

  13. 41 CFR 105-72.301 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... Management § 105-72.301 Standards for financial management systems. (a) Federal awarding agencies shall... practical. (b) Recipients' financial management systems shall provide for the following. (1) Accurate... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Standards for...

  14. 78 FR 2443 - Criminal Justice Interview Room Recording System (IRRS) Standard, Supplier's Declaration of...

    Science.gov (United States)

    2013-01-11

    ... Office of Justice Programs Criminal Justice Interview Room Recording System (IRRS) Standard, Supplier's... Recording Systems (IRRS) used by criminal justice agencies: 1. Draft Criminal Justice IRRS Standard 2. Draft Criminal Justice IRRS Supplier's Declaration of Conformity Requirements 3. Draft Criminal Justice...

  15. EXPERIENCE OF IMPLEMENTATION OF THE LABOR PROTECTION CONTROL SYSTEM AT RUP «BMZ» IN ACCORDANCE WITH INTERNATIONAL STANDARDS OHSAS 180001 AND STATE STANDARD STB 18001

    Directory of Open Access Journals (Sweden)

    I. N. Zhuk

    2010-01-01

    Full Text Available Experience of introduction of the control system by labour protection at RUP «BMZ» in accordance with international standard OHSAS 18001 and State standard STB 18001 is described.

  16. Upper airway oedema following autologous blood transfusion from a wound drainage system.

    Science.gov (United States)

    Woda, R; Tetzlaff, J E

    1992-03-01

    We report a case of a 70-yr-old white woman who underwent a revision of a total hip arthroplasty under general anaesthesia. The intraoperative course was stable without any complications and the estimated blood loss was 2500 ml. The patient received an autologous transfusion of blood from a wound drainage system in the recovery room. The transfusion was followed immediately by marked respiratory distress and upper airway oedema. She required emergency tracheal intubation and mechanical pulmonary ventilation. A coagulopathy also developed which was treated and resolved within 12 hr of the capillary leak phenomenon. The trachea was extubated on the first postoperative day and she had an uneventful course until discharge from the hospital two days later. We discuss the possible, aetiology of such a reaction to autologous blood including complement and platelet activation. It is suggested that reinfusion of nonwashed shed blood from a wound drainage system may present a hazard even though the fluid was autologous in origin. PMID:1551163

  17. ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM

    Directory of Open Access Journals (Sweden)

    B. G. Yushkov

    2010-01-01

    Full Text Available Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.

  18. Improvement in fetal DNA extraction from maternal plasma. Evaluation of the NucliSens Magnetic Extraction system and the QIAamp DSP Virus Kit in comparison with the QIAamp DNA Blood Mini Kit

    DEFF Research Database (Denmark)

    Clausen, Frederik Banch; Krog, Grethe Risum; Rieneck, Klaus;

    2007-01-01

    Prenatal diagnostic assays have been developed using free fetal DNA circulating in the maternal blood of pregnant women. Efficient DNA extraction is crucial for a robust analysis. To improve fetal DNA yield, we tested two manual extraction methods--the NucliSens Magnetic Extraction (NMAG) system...... and the QIAamp DSP Virus Kit (QDSP)--against our current standard method, the widely used QIAamp DNA Blood Mini Kit (QDNA)....

  19. 2型糖尿病病人血糖达标率的研究进展%Research progress on standard rate of blood glucose of type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    刘婷; 王惠连

    2012-01-01

    Type 2 diabetes is a common and chronic life - long disease, but standard rate of blood sugar of the patients is generally lower. This study reviewed the research progress of standard rate of blood sugar from aspects of the definition of standard rate and compliance of blood sugar,the status quo of standard rate of blood sugar,influence of standard rate of blood sugar on complications influencing factors of standard rate of blood sugar and interventions.%2型糖尿病是一种常见、慢性终身性疾病,但是病人血糖达标率普遍较低.本研究从血糖达标率和依从性的定义、血糖达标率的现状、血糖达标率对并发症的影响、血糖达标率的影响因素及干预等方面综述了2型糖尿病病人血糖达标率的研究进展.

  20. Effect of magnetic bracelets on the coagulation and anticoagulation systems of the blood of patients with hypertension

    Science.gov (United States)

    Bublis, V. V.; Zabrodina, L. V.; Platonova, A. T.; Meyerova, Y. A.

    1974-01-01

    The data which have been obtained on the influence of magnetic bracelets on the coagulation and anticoagulation systems of the blood indicate that the wearing of magnetic bracelets results in a decrease in the coagulation activity of the blood and an increase in the activity of the anticoagulation system. These changes must be viewed as favorable for patients with cardiovascular pathology.

  1. 轻中度高血压患者血压达标后动态血压及血压节律的变化特点%Change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension

    Institute of Scientific and Technical Information of China (English)

    韩楠楠; 王其新

    2011-01-01

    目的 探讨轻中度高血压患者血压达标后动态血压及血压节律的变化特点.方法 选择124名轻中度高血压患者,给予口服厄贝沙坦/氢氯噻嗪复方制剂(每片含厄贝沙坦150 mg及氢氯噻嗪12.5 mg)控制血压,目标血压值为<130/85 mm Hg(1 mm Hg=0.133 kPa),根据血压达标情况增加药物剂量,观察时间为14~16 d.记录血压达标患者治疗前后动态血压参数及血压达标所需时间.结果 治疗后共70例患者血压达标,血压达标患者24 h收缩压(SBP),24 h舒张压(DBP),昼间平均SBP,昼间平均DBP,夜间平均SBP,夜间平均DBP及脉压在治疗前后差异均有统计学意义(P均<0.05).治疗后血压达标患者的血压节律构成比发生变化,正常血压节律患者的比例由治疗前52.8%增加至治疗后的81.4%,治疗前后血压节律构成比的差异有统计学意义(P<0.05).血压达标患者中血压节律正常者与血压节律异常者血压达标所需天数分别为[(7.70±2.20)d vs.(9.21±2.63)d],差异有统计学意义(P<0.05).结论 厄贝沙坦/氢氯噻嗪复方制剂降低轻中度高血压患者血压的同时,改善了血压达标患者的昼夜血压节律.%Objective To explore the change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension. Methods The patients with mild or moderate hypertension ( n = 124 ) were selected and orally given the compound preparation of irbesartan-hydrochlorothiazide ( 150 mg irbesartan and 12. 5 mg hydrochlorothiazide in one table ) for controling blood pressure. The target blood pressure was lower than 130/85 mm Hg ( 1 mm Hg =0. 133 kPa ). The dose of medicinal was increased according to the targeting state of blood pressure. The observation was kept on for 14-16 days. The parameters of ambulatory blood pressure and required time for blood pressure reaching standard were recorded in the patients after blood

  2. Determination of lead in whole blood: Comparison of the LeadCare blood lead testing system with zeeman longitudinal electrothermal atomic absorption spectrometry

    International Nuclear Information System (INIS)

    This study compares the efficiency of blood lead level analysis by graphite furnace atomic absorption spectrometry (GFAAS) and the portable LeadCare Blood lead testing system (LCS). Recoveries of two added lead concentrations of 22 and 42 μg/dL ranged from 102.4 to 105.5% for LCS and from 96.3 to 97.2% for GFAAS. Measurement of a certified sample (Certified Danish Whole Blood) at a blood lead concentration of 26.2 μg/dL gave within- and between-run coefficients of variation which were both approximately 8% by LCS and 2% by GFAAS. Comparison of the tested method (LCS) versus GFAAS from analysis of 76 samples of blood lead collected from workers in different industrial sectors showed imperfect overall correlation (r = 0.95). The LCS is quite suitable for screening purposes, but requires the use of non-frozen blood collected less than 24 h before. Conservative threshold values should be applied when using the LCS for initial screening in the field. (orig.)

  3. Reducing barriers to interoperability through collaborative development of standards for Earth science information systems

    Science.gov (United States)

    Percivall, G. S.; Arctur, D. K.

    2010-12-01

    Increasingly, Earth science research must make effective use of interdisciplinary data sources and processes. Non-interoperability impedes sharing of data and computing resources. Standards from the Open Geospatial Consortium (OGC) and other organizations are the basis for successfully deploying a seamless, distributed information infrastructure for the geosciences. Collaborative development of the standards has proven effective in reducing barriers to standards adoption. Standards are the basis for the success of the Internet and the World Wide Web. A standard describes a set of rules that have been agreed to in some consensus forum, such as the Internet Engineering Task Force (IETF), the International Organization for Standardization (ISO), or the OGC. As described in The Importance of Going Open, “non-interoperability causes organizations to spend much more than necessary on geospatial information technology development”. In the context of e-Science, the National Science Foundation’s Cyberinfrastructure Council argues that “The use of standards creates economies of scale and scope for developing and deploying common resources, tools, software, and services that enhance the use of cyberinfrastructure in multiple science and engineering communities.” Barriers to adoption include misperceptions and misuse of standards. “Adhering to standards costs more” - typically this statement is made when a research program considers implementing standards as a one-time modification to an existing system. Multiple economic studies have shown lower development costs when using standards over the life of a project. “Standards stifle innovation” - a key decision in research is to consider what assumptions to consider fixed and what to challenge. The long history of standards in research, e.g., SI units, is fundamental to assessing repeatable results by independent researchers. Similar need for common standards exist in the information systems used for Earth

  4. Evaluation of a content-based retrieval system for blood cell images with automated methods.

    Science.gov (United States)

    Seng, Woo Chaw; Mirisaee, Seyed Hadi

    2011-08-01

    Content-based image retrieval techniques have been extensively studied for the past few years. With the growth of digital medical image databases, the demand for content-based analysis and retrieval tools has been increasing remarkably. Blood cell image is a key diagnostic tool for hematologists. An automated system that can retrieved relevant blood cell images correctly and efficiently would save the effort and time of hematologists. The purpose of this work is to develop such a content-based image retrieval system. Global color histogram and wavelet-based methods are used in the prototype. The system allows users to search by providing a query image and select one of four implemented methods. The obtained results demonstrate the proposed extended query refinement has the potential to capture a user's high level query and perception subjectivity by dynamically giving better query combinations. Color-based methods performed better than wavelet-based methods with regard to precision, recall rate and retrieval time. Shape and density of blood cells are suggested as measurements for future improvement. The system developed is useful for undergraduate education. PMID:20703533

  5. A SYSTEM AND A DEVICE FOR ISOLATING CIRCULATING TUMOR CELLS FROM THE PERIPHERAL BLOOD IN VIVO

    Directory of Open Access Journals (Sweden)

    Michal Mego

    2015-08-01

    Full Text Available Circulating tumor cells (CTC play a crucial role in disseminating tumors and in the metastatic cascade. CTCs are found only in small numbers, and the limited amount of isolated CTCs makes it impossible to characterize them closely. This paper presents a proposal for a new system for isolating CTCs from the peripheral blood in vivo. The system enables CTCs to be isolated from the whole blood volume for further research and applications. The proposed system consists of magnetic nanoparticles covered by monoclonal antibodies against a common epithelial antigen, large supermagnets, which are used to control the position of the nanoparticles within the human body, and a special wire made of a magnetic core wrapped in a non-magnetic shell. The system could be used not only for isolating CTCs, but also for in vivo isolation of other rare cells from the peripheral blood, including hematopoietic and/or mesenchymal stem cells, with applications in regenerative medicine and/or in stem cell transplantation.

  6. Standard marking system for valves, fittings, flanges and unions

    International Nuclear Information System (INIS)

    The marking system described applies to valves, fittings, flanges and unions used in piping connections which include flanged, soldered, brazed, threaded or welded joints. These specified markings serve to identify the manufacturer, rating designation, materials of construction, and special service limitations imposed by the manufacturer

  7. 22 CFR 226.21 - Standards for financial management systems.

    Science.gov (United States)

    2010-04-01

    ... principles and the terms and conditions of the award. (7) Accounting records, including cost accounting... accounting system. These recipients may develop such accrual data for their reports on the basis of an... the CMIA default procedures codified at 31 CFR part 205, “Withdrawal of Cash from the Treasury...

  8. 40 CFR 35.6550 - Procurement system standards.

    Science.gov (United States)

    2010-07-01

    ... ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Procurement Requirements Under A Cooperative Agreement § 35.6550 Procurement system...) Award. The recipient may award a contract only to a responsible contractor, as described in 40 CFR...

  9. Development of the module inspection system for new standardized radiation monitoring modules

    International Nuclear Information System (INIS)

    This report mentions about the module inspection system which does the maintenance check of the monitoring modules adapted the new monitoring standard, as well as the result of the verification of the modules. The module inspection system is the automatic measurement system with the computer. The system can perform the functional and the characteristic examination of the monitoring modules, the calibration with radiation source and inspection report. In the verification of the monitoring module, three major items were tested, the adaptability for the new monitoring standard, the module functions and each characteristics. All items met the new monitoring standard. (author)

  10. Linkage disequilibrium between the ELA and the A blood group systems in Standardbred horses.

    Science.gov (United States)

    Bailey, E

    1983-01-01

    The linkage group formed by the ELA and A blood group system in horses was studied in American Standardbred horses. The distance between the ELA locus and the A blood group locus was measured as 1.61 centimorgans, observing only the haplotypes contributed by the sires. Strong linkage disequilibrium was found in pacing Standardbred horses for ELA-W1 with Aa, ELA-W5 with Ab and ELA-W10 with Ab. Linkage disequilibrium was apparent at both the population and family level. Among trotting Standardbred horses, linkage disequilibrium was found for ELA-W1 with Aa and for ELA-W10 with Ab. It was not possible to investigate linkage relationships in Thoroughbred horses because of the high frequency of Aa and low frequency of other A system markers.

  11. Rh, Kell, Duffy, Kidd and Diego blood group system polymorphism in Brazilian Japanese descendants.

    Science.gov (United States)

    Flôres, Marli Aparecida Luvisuto Rossett; Visentainer, Jeane Eliete Laguila; Guelsin, Gláucia Andréia Soares; Fracasso, Adriana de Souza; de Melo, Fabiano Cavalcante; Hashimoto, Margareth Naomi; Sell, Ana Maria

    2014-02-01

    Polymorphisms of Rh, Kell, Duffy, Kidd and Diego blood group systems were studied in 209 unrelated Brazilian Japanese descendants from South of Brazil. The methods used were multiplex-PCR, AS-PCR and RFLP-PCR. The differences in frequencies among the populations were evaluated using chi-square test. The frequencies for Rh, Kell, Kidd and Diego system were similar to those of the Japanese. RHCE(*)CC, RHCE(*)EE genotypes and FY(*)01 allele were lower and FY(*)01N.01 was higher than Japanese. These differences in the frequencies between Brazilian Japanese descendants and Japanese could indicate a gene flow in Brazilian population and reinforce the importance of this knowledge to achieve safe red blood cells. PMID:24231689

  12. Results in standardization of FOS to support the use of SHM systems

    Science.gov (United States)

    Habel, Wolfgang R.; Krebber, Katerina; Daum, Werner

    2016-05-01

    Measurement and data recording systems are important parts of a holistic Structural Health Monitoring (SHM) system. New sensor technologies such as fiber-optic sensors are often used; however, standards (or at least guidelines) are not yet available or internationally approved. This lack in standardization makes the acceptance of FOS technologies in complex SHM systems substantially difficult. A standard family for different FOS technologies is therefore being developed that should help to design SHM systems in an optimal way. International standardization activities take place in several standardization bodies such as IEC and ASTM, and within SHM societies such as ISHMII. The paper reports on activities in standardization of fiber-optic sensors, on results already achieved, and on newly started projects. Combined activities of fiber sensor experts and SHM experts from Civil Engineering are presented. These contributions should help owners of structures as well as developers of sensors and monitoring systems to select effective and validated sensing technologies. Using these standards, both parties find recommendations how to proceed in development of SHM systems to evaluate the structural behavior based on e.g. standardized fiber optic sensors, and to derive necessary measures, e.g. the optimal maintenance strategy.

  13. Establishment of the {sup 222}Rn traceability chain with the Romanian standard system

    Energy Technology Data Exchange (ETDEWEB)

    Sahagia, M., E-mail: msahagia@nipne.r [' Horia Hulubei' National Institute of R and D for Physics and Nuclear Engineering, IFIN-HH, POB MG-6, 077125 Bucharest (Romania); Luca, A.; Waetjen, A.C.; Antohe, A.; Ivan, C. [' Horia Hulubei' National Institute of R and D for Physics and Nuclear Engineering, IFIN-HH, POB MG-6, 077125 Bucharest (Romania); Varlam, C.; Faurescu, I. [National Institute of R and D for Cryogenic and Isotopic Technologies, ICSI Rm. Valcea (Romania); Cassette, P. [LNE-CEA, LIST, Laboratoire National Henri Becquerel, F-91191 Gif-sur-Yvette (France)

    2011-03-01

    This paper presents the results obtained in the establishment of the upper level of the traceability chain, primary and secondary {sup 222}Rn measurements, with the standard system realized at IFIN-HH, Romania. The following subjects are presented: (i) the principle of establishing the traceability chain; (ii) the setting up of the final metallic system for the radon standardization and the experimental method; (iii) results obtained in the realization of the traceability chain, by absolute radon standardization with the liquid scintillation counting method (LSC) and relative measurements of activity, using the HPGe gamma-ray spectrometry method and the CENTRONIC IG12/20A ionization chamber, and its validation. The final purpose of the work is to calibrate adequately the secondary standard systems, HPGe spectrometer and ionization chamber, for using them in the measurement of the working standards, various types of recipients containing radon gas, prepared in the laboratory with the radon system.

  14. Artificial heart system thermal converter and blood pump component research and development

    International Nuclear Information System (INIS)

    A bench model version of a nuclear-powered artificial heart system to be used as a replacement for the natural heart was constructed and tested as a part of a broader U. S. ERDA program. The objective of the broader program has been to develop a prototype of a fully implantable nuclear-powered total artificial heart system powered by the thermal energy of plutonium-238 and having minimum weight and volume and a minimum life of ten years. As a forward step in this broader program, component research and development has been carried out directed towards a fully implantable and advanced version of the bench model (IVBM). Some of the results of the component research and development effort on a Stirling engine, blood pump drive mechanisms, and coupling mechanisms are presented. The Stirling-mechanical system under development is shown. There are three major subassemblies: the thermal converter, the coupling mechanism, and the blood pump drive mechanism. The thermal converter uses a Stirling cycle to convert the heat of the plutonium-238 fueled heat source to a rotary shaft power output. The coupling mechanism changes the orientation of the output shaft by 90 degrees and transmits the pumping power by wire-wound core flexible shafting to the pumping mechanism. The coupling mechanism also provides routing of the coolant lines which carry the cycle waste heat from the thermal converter to the blood pump. The change in orientation of the thermal converter output shaft is for convenience in implanting in a calf. This orientation of thermal converter to blood pump seemed to give the best overall system fit in a calf based on fit trials with wooden models in a calf cadaver

  15. Standard Hydrogen Monitoring System-C operation and maintenance manual

    International Nuclear Information System (INIS)

    The primary function of the SHMS-C is to monitor specifically for hydrogen in the waste tank vapor space which may also contain (but not be limited to) unknown quantities of air, nitrous oxide (N2O), ammonia (NH3), water vapor, carbon dioxide (CO2), carbon monoxide (CO) and other gaseous constituents. An electronically controlled grab sampler has replaced the manually operated sample system that was used in the original SHMS enclosure. Samples can now be operator or automatically initiated. Automatic initiation occurs based on the high hydrogen alarm level. Once a sample is obtained it is removed from the sampler and transported to a laboratory for analysis. This system is used to identify other gaseous constituents which are not measured by the hydrogen monitor. The design does not include any remote data acquisition or remote data logging equipment but provides a 4--20 mA dc process signals, and discrete alarm contacts, that can be utilized for remote data logging and alarming when desired. The SHMS-C arrangement consists of design modifications (piping, valves, filters, supports) to the SHMS-B arrangement necessary for the installation of a dual column gas chromatograph and associated sample and calibration gas lines. The gas chromatograph will provide real time, analytical quality, specific hydrogen measurements in low and medium range concentrations. The system is designed to sample process gases that are classified by NEC code as Class 1, Division 1, Group B

  16. Systemic chemotherapy induces microsatellite instability in the peripheral blood mononuclear cells of breast cancer patients

    International Nuclear Information System (INIS)

    Systemic chemotherapy is an important part of treatment for breast cancer. We conducted the present study to evaluate whether systemic chemotherapy could produce microsatellite instability (MSI) in the peripheral blood mononuclear cell fraction of breast cancer patients. We studied 119 sequential blood samples from 30 previously untreated breast cancer patients before, during and after chemotherapy. For comparison, we also evaluated 20 women who had no relevant medical history (control group). In 27 out of 30 patients we observed MSI in at least one sample, and six patients had loss of heterozygosity. We found a significant correlation between the number of MSI events per sample and chemotherapy with alkylating agents (P < 0.0001). We also observed an inverse correlation between the percentage of cells positive for hMSH2 and the number of MSI events per sample (P = 0.00019) and use of alkylating agents (P = 0.019). We conclude that systemic chemotherapy may induce MSI and loss of heterozygosity in peripheral blood mononuclear cells from breast cancer patients receiving alkylating agents, possibly mediated by a chemotherapy-induced decrease in the expression of hMSH2. These effects may be related to the generation of secondary leukaemia in some patients, and may also intensify the genetic instability of tumours and increase resistance to treatment

  17. Nanoparticles and blood-brain barrier: the key to central nervous system diseases.

    Science.gov (United States)

    Domínguez, Alazne; Suárez-Merino, Blanca; Goñi-de-Cerio, Felipe

    2014-01-01

    Major central nervous system disorders represent a significant and worldwide public health problem. In fact, the therapeutic success of many pharmaceuticals developed to treat central nervous system diseases is still moderate, since the blood-brain barrier (BBB) limits the access of systemically administered compounds to the brain. Therefore, they require the application of a large total dose of a drug, and cause numerous toxic effects. The development of nanotechnological systems are useful tools to deliver therapeutics and/or diagnostic probes to the brain due to nanocarriers having the potential to improve the therapeutic effect of drugs and to reduce their side effects. This review provides a brief overview of the variety of carriers employed for central nervous system drug and diagnostic probes delivery. Further, this paper focuses on the novel nanocarriers developed to enhance brain delivery across the blood-brain barrier. Special attention is paid to liposomes, micelles, polymeric and lipid-based nanoparticles, dendrimers and carbon nanotubes. The recent developments in nanocarrier implementation through size/charge optimization and surface modifications (PEGylation, targeting delivery, and coating with surfactants) have been discussed. And a detailed description of the nanoscaled pharmaceutical delivery devices employed for the treatment of central nervous system disorders have also been defined. The aim of the review is to evaluate the nanotechnology-based drug delivery strategies to treat different central nervous system disorders.

  18. A System for Simple Real-Time Anastomotic Failure Detection and Wireless Blood Flow Monitoring in the Lower Limbs

    Science.gov (United States)

    Rothfuss, Michael A.; Franconi, Nicholas G.; Unadkat, Jignesh V.; Gimbel, Michael L.; STAR, Alexander; Mickle, Marlin H.

    2016-01-01

    Current totally implantable wireless blood flow monitors are large and cannot operate alongside nearby monitors. To alleviate the problems with the current monitors, we developed a system to monitor blood flow wirelessly, with a simple and easily interpretable real-time output. To the best of our knowledge, the implanted electronics are the smallest in reported literature, which reduces bio-burden. Calibration was performed across realistic physiological flow ranges using a syringe pump. The device’s sensors connected directly to the bilateral femoral veins of swine. For each 1 min, blood flow was monitored, then, an occlusion was introduced, and then, the occlusion was removed to resume flow. Each vein of four pigs was monitored four times, totaling 32 data collections. The implant measured 1.70 cm3 without battery/encapsulation. Across its calibrated range, including equipment tolerances, the relative error is less than ±5% above 8 mL/min and between −0.8% and +1.2% at its largest calibrated flow rate, which to the best of our knowledge is the lowest reported in the literature across the measured calibration range. The average standard deviation of the flow waveform amplitude was three times greater than that of no-flow. Establishing the relative amplitude for the flow and no-flow waveforms was found necessary, particularly for noise modulated Doppler signals. Its size and accuracy, compared with other microcontroller-equipped totally implantable monitors, make it a good candidate for future tether-free free flap monitoring studies. PMID:27730016

  19. Product specification documentation standard and Data Item Descriptions (DID). Volume of the information system life-cycle and documentation standards, volume 3

    Science.gov (United States)

    Callender, E. David; Steinbacher, Jody

    1989-01-01

    This is the third of five volumes on Information System Life-Cycle and Documentation Standards which present a well organized, easily used standard for providing technical information needed for developing information systems, components, and related processes. This volume states the Software Management and Assurance Program documentation standard for a product specification document and for data item descriptions. The framework can be applied to any NASA information system, software, hardware, operational procedures components, and related processes.

  20. СALCULATION OF THE VERTICAL GATING SYSTEMS WITH USAGE OF STANDARD ELEMENTS

    OpenAIRE

    A. A. Tonkovich; A. A. Skvortsov

    2016-01-01

    Methodology of the calculation of the vertical gating systems for DISA automatic lines with use of the standardized elements is given in the article. The example of calculation of the gating system for a concrete article and results of modeling of the developed gating system with use of packages of the applied programs ProCast, Poligon are presented. The example of a choice of the standard feeder on the cooling module is given.

  1. 25 CFR 276.7 - Standards for grantee financial management systems.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Standards for grantee financial management systems. 276.7... grantee financial management systems. (a) Grantee financial management systems for grants and subgrantee financial management systems for subgrants shall provide for: (1) Accurate, current, and complete...

  2. A Framework for a Smart Social Blood Donation System Based on Mobile Cloud Computing

    OpenAIRE

    Mostafa, Almetwally M.; Youssef, Ahmed E.; Alshorbagy, Gamal

    2014-01-01

    Blood Donation and Blood Transfusion Services (BTS) are crucial for saving people lives. Recently, worldwide efforts have been undertaken to utilize social media and smartphone applications to make the blood donation process more convenient, offer additional services, and create communities around blood donation centers. Blood banks suffer frequent shortage of blood; hence, advertisements are frequently seen on social networks urging healthy individuals to donate blood for patients who urgent...

  3. [Kallikrein-kinin system of blood in patients in the post-infarction period, and its reaction to physical exertion].

    Science.gov (United States)

    Azimova, F I; Nekrasova, A A; Chernova, N A; Nikolaeva, L F

    1983-09-01

    Blood kallikrein-kinin function was assessed in myocardial infarction survivors. Increased blood kinin-forming activity was demonstrated, accompanied with a simultaneous rise in the system's inhibitor level and excessive response to exercise, with slower regaining of the baseline after exercise was discontinued. It is concluded that functional testing of blood kallikrein-kinin status by means of rationed exercise yields more informative data on this system in various groups of postinfarction patients and that the extent of the system's activation depends on systemic circulatory function.

  4. Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system

    OpenAIRE

    Siddiqui, Ruqaiyyah; Edwards-Smallbone, James; Flynn, Robin; Khan, Naveed Ahmed

    2012-01-01

    Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented o...

  5. An integrated methodology to develop a standard for landslide early warning systems

    Science.gov (United States)

    Faisal Fathani, Teuku; Karnawati, Dwikorita; Wilopo, Wahyu

    2016-09-01

    Landslides are one of the most widespread and commonly occurring natural hazards. In regions of high vulnerability, these complex hazards can cause significant negative social and economic impacts. Considering the worldwide susceptibility to landslides, it is necessary to establish a standard for early warning systems specific to landslide disaster risk reduction. This standard would provide guidance in conducting landslide detection, prediction, interpretation, and response. This paper proposes a new standard consisting of seven sub-systems for landslide early warning. These include risk assessment and mapping, dissemination and communication, establishment of the disaster preparedness and response team, development of an evacuation map, standardized operating procedures, installation of monitoring and warning services, and the building of local commitment to the operation and maintenance of the entire program. This paper details the global standard with an example of its application from Central Java, one of 20 landslide-prone provinces in Indonesia that have used this standard since 2012.

  6. Design and development of a tele-healthcare information system based on web services and HL7 standards.

    Science.gov (United States)

    Huang, Ean-Wen; Hung, Rui-Suan; Chiou, Shwu-Fen; Liu, Fei-Ying; Liou, Der-Ming

    2011-01-01

    Information and communication technologies progress rapidly and many novel applications have been developed in many domains of human life. In recent years, the demand for healthcare services has been growing because of the increase in the elderly population. Consequently, a number of healthcare institutions have focused on creating technologies to reduce extraneous work and improve the quality of service. In this study, an information platform for tele- healthcare services was implemented. The architecture of the platform included a web-based application server and client system. The client system was able to retrieve the blood pressure and glucose levels of a patient stored in measurement instruments through Bluetooth wireless transmission. The web application server assisted the staffs and clients in analyzing the health conditions of patients. In addition, the server provided face-to-face communications and instructions through remote video devices. The platform deployed a service-oriented architecture, which consisted of HL7 standard messages and web service components. The platform could transfer health records into HL7 standard clinical document architecture for data exchange with other organizations. The prototyping system was pretested and evaluated in a homecare department of hospital and a community management center for chronic disease monitoring. Based on the results of this study, this system is expected to improve the quality of healthcare services. PMID:21431601

  7. Comparison of pituitary and recombinant human thyrotropin standards in an immunoradiometric system

    International Nuclear Information System (INIS)

    Results of two standards of human thyrotropin of pituitaries (B) and recombinant (C) origen supplied by the Instituto of pesquisas Energeticas y Nucleares, Brazil, were compared in our immunoradiometric reference system that use an human thyrotropin pituitary standard of local production (A). This work was supported by the International Atomic Energy Agency for an inter-regional comparison and set up of a reference standard

  8. Interpretation of IEEE-854 floating-point standard and definition in the HOL system

    Science.gov (United States)

    Carreno, Victor A.

    1995-01-01

    The ANSI/IEEE Standard 854-1987 for floating-point arithmetic is interpreted by converting the lexical descriptions in the standard into mathematical conditional descriptions organized in tables. The standard is represented in higher-order logic within the framework of the HOL (Higher Order Logic) system. The paper is divided in two parts with the first part the interpretation and the second part the description in HOL.

  9. Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

    Directory of Open Access Journals (Sweden)

    Sojka Daniel

    2010-12-01

    Full Text Available Abstract Background Ticks are vectors of a wide variety of pathogens causing severe diseases in humans and domestic animals. Intestinal digestion of the host blood is an essential process of tick physiology and also a limiting factor for pathogen transmission since the tick gut represents the primary site for pathogen infection and proliferation. Using the model tick Ixodes ricinus, the European Lyme disease vector, we have previously demonstrated by genetic and biochemical analyses that host blood is degraded in the tick gut by a network of acidic peptidases of the aspartic and cysteine classes. Results This study reveals the digestive machinery of the I. ricinus during the course of blood-feeding on the host. The dynamic profiling of concentrations, activities and mRNA expressions of the major digestive enzymes demonstrates that the de novo synthesis of peptidases triggers the dramatic increase of the hemoglobinolytic activity along the feeding period. Overall hemoglobinolysis, as well as the activity of digestive peptidases are negligible at the early stage of feeding, but increase dramatically towards the end of the slow feeding period, reaching maxima in fully fed ticks. This finding contradicts the established opinion that blood digestion is reduced at the end of engorgement. Furthermore, we show that the digestive proteolysis is localized intracellularly throughout the whole duration of feeding. Conclusions Results suggest that the egressing proteolytic system in the early stage of feeding and digestion is a potential target for efficient impairment, most likely by blocking its components via antibodies present in the host blood. Therefore, digestive enzymes are promising candidates for development of novel 'anti-tick' vaccines capable of tick control and even transmission of tick-borne pathogens.

  10. Design of mobile telemedicine systems using GSM and IS-54 cellular telephone standards.

    Science.gov (United States)

    Istepanian, R H; Woodward, B; Gorilas, E; Balos, P A

    1998-01-01

    This paper presents an overview of the design of mobile telemedical systems using cellular telephone channels. A mobile telemedicine communication system was studied using both the GSM and the IS-54 standards, which are the most widely used commercial cellular telephone systems in Europe and North America, respectively. A simulation using a photoplethesmography signal showed successful transmission of data with bit error rates of less than 10(-7) at the receiver for the IS-54 standard and less than 10(-5) for the GSM standard, depending on the mobile channel conditions used. PMID:9640747

  11. Blood hibernation: a novel strategy to inhibit systemic inflammation and coagulation induced by cardiopulmonary bypass

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jing; WU Xiao-dong; LIN Ke; Raphael C. Lui; AN Qi; TAO Kai-yu; DU Lei; LIU Jin

    2010-01-01

    Background Inflammation and coagulation are two intimately cross-linked defense mechanisms of most, if not all organisms to injuries. During cardiopulmonary bypass (CPB), these two process-is are activated and interact with each other through several common pathways, which may result in subsequent organ dysfunction. In the present study, we hypothesized that the addition of nitric oxide, prostaglandin E1 (PGE1), and aprotinin to the systemic circulation, hereby referred to as blood hibernation, would attenuate the inflammation and coagulation induced by CPB. Methods Thirty adult mongrel dogs were equally divided into five groups, anesthetized and placed on hypothermic CPB (32 C). Each group received respectively the following treatments: (1) inhalation of 40 ppm nitric oxide; (2) intravenous infusion of 20 ng·kg-1·min-1 of PGE1; (3) 80 000 kallikrein inhibitor units (KIU)/kg of aprotinin; (4) the combination of all three agents (blood hibernation group); and (5) no treatment (control group) during CPB. Activation of leukocyte, platelet, endothelial cell, and formation of thrombin were assessed after CPB.Results As compared with the other four groups, leukocyte counts were higher, while plasma elastase, interleukin-8, CD11b mRNA expression, myeloperoxidase activities and lung tissue leukocyte counts were lower in the blood hibernation group (P<0.05 versus other four groups after CPB). Plasma prothrombin fragment (PTF)1+2, and platelet activation factors were lower, while platelet counts were higher in the blood hibernation group (P<0.05 versus other four groups at 6 and 12 hours after CPB). Electron microscopy showed endothelial pseudopods protrusion, with cell adherence in all four groups except the blood hibernation group where endothelial cells remained intact.Conclusion Blood hibernation, effected by the addition of nitric oxide, PGE1 and aprotinin to the circulating blood during extra-corporeal circulation, was observed to attenuate the inflammation and

  12. Iso 19011:2002--a combined auditing standard for quality and environmental management systems.

    Science.gov (United States)

    Johnson, G L

    2000-01-01

    In a precedent-setting decision in 1998, the International Organization for Standardization (ISO) directed ISO Technical Committee (TC) 176 on Quality Management and ISO TC 207 on Environmental Management to develop jointly a single guideline standard for auditing quality and environmental management systems. When approved, this standard would replace ISO 10011-1, ISO 10011-2, and ISO 10011-3 on quality auditing and ISO 14010, ISO 14011, and ISO 14012 on environmental auditing. A Joint Working Group (JWG) was established comprising experts from both TC 176 and TC 207 to develop the new standard, ISO 19011, Guidelines on Quality and/or Environmental Management Systems Auditing, and to incorporate lessons learned from efforts to improve compatibility between ISO 9001/9004 and ISO 14001/14004, the standards for quality and environmental management systems, respectively. Work is proceeding on the development of ISO 19011 with an expected completion in early 2002.

  13. Study of a centrifugal blood pump in a mock loop system.

    Science.gov (United States)

    Uebelhart, Beatriz; da Silva, Bruno Utiyama; Fonseca, Jeison; Bock, Eduardo; Leme, Juliana; da Silva, Cibele; Leão, Tarcísio; Andrade, Aron

    2013-11-01

    An implantable centrifugal blood pump (ICBP) is being developed to be used as a ventricular assist device (VAD) in patients with severe cardiovascular diseases. The ICBP system is composed of a centrifugal pump, a motor, a controller, and a power supply. The electricity source provides power to the controller and to a motor that moves the pump's rotor through magnetic coupling. The centrifugal pump is composed of four parts: external conical house, external base, impeller, and impeller base. The rotor is supported by a pivot bearing system, and its impeller base is responsible for sheltering four permanent magnets. A hybrid cardiovascular simulator (HCS) was used to evaluate the ICBP's performance. A heart failure (HF) (when the heart increases beat frequency to compensate for decrease in blood flow) was simulated in the HCS. The main objective of this work is to analyze changes in physiological parameters such as cardiac output, blood pressure, and heart rate in three situations: healthy heart, HF, and HF with left circulatory assistance by ICBP. The results showed that parameters such as aortic pressure and cardiac output affected by the HF situation returned to normal values when the ICBP was connected to the HCS. In conclusion, the test results showed satisfactory performance for the ICBP as a VAD.

  14. Duffy blood group system and the malaria adaptation process in humans

    Directory of Open Access Journals (Sweden)

    Gledson Barbosa de Carvalho

    2011-02-01

    Full Text Available Malaria is an acute infectious disease caused by the protozoa of the genus Plasmodium. The antigens of the Duffy Blood Group System, in addition to incompatibilities in transfusions and hemolytic disease of the newborn, are of great interest in medicine due to their association with the invasion of red blood cells by the parasite Plasmodium vivax. For invasions to occur an interaction between the parasites and antigens of the Duffy Blood Group System is necessary. In Caucasians six antigens are produced by the Duffy locus (Fya, Fyb, F3, F4, F5 and F6. It has been observed that Fy(a-b- individuals are resistant to Plasmodium knowlesi and P. vivax infection, because the invasion requires at least one of these antigens. The P. vivax Duffy Binding Protein (PvDBP is functionally important in the invasion process of these parasites in Duffy / DARC positive humans. The proteins or fractions may be considered, therefore, an important and potential inoculum to be used in immunization against malaria.

  15. A Mathematical Model of Renal Blood Distribution Coupling TGF, MR and Tubular System

    Institute of Scientific and Technical Information of China (English)

    GAO Ci-xiu; YANG Lin; WANG Ke-qiang; XU Shi-xiong; DAI Pei-dong

    2009-01-01

    Objective:To investigate the relationship between renal blood distribution and the physiological activities of the kidney. Methods:A mathematical model is developed based on Hagan-Poiseuille law and mass transport, coupling mechanics of myogenic response (MR), tubuloglomerular feedback (TGF) and the tubular system in the renal medulla. The model parameters, including the permeability coefficients, the vascular lumen radius and the solute concentration at the inlet of the tubes, are derived from the experimental results. Simulations of the blood and water flow in the loop of Henel, the collecting duct and vas rectum, are carried out by the model of the tubular system in the renal medulla, based on conservations of water and solutes for transmural transport. Then the tubular model is coupled with MR and TGF mechanics. Results:The results predict the dynamics of renal autoregulation on its blood pressure and flow,and the distributions are 88.5% in the cortex, 10.3% in the medulla, and 1.2% at papilla,respectively. The fluid flow and solute concentrations along the tubules and vasa recta are obtained. Conclusion:The present model could assess renal functions qualitatively and quantitatively and provide a methodological approach for clinical research.

  16. 14 CFR 25.1445 - Equipment standards for the oxygen distributing system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Equipment standards for the oxygen... Miscellaneous Equipment § 25.1445 Equipment standards for the oxygen distributing system. (a) When oxygen is... crew on duty. (b) Portable walk-around oxygen units of the continuous flow, diluter-demand,...

  17. 78 FR 24061 - Minimum Technical Standards for Class II Gaming Systems and Equipment

    Science.gov (United States)

    2013-04-24

    ... ensuring the integrity of electronic Class II games and aids. 73 FR 60508, Oct. 10, 2008. The technical... Class II gaming system; and to clarify the term ``alternate standard.'' 77 FR 58473, Sept. 21, 2012. In... control standards (MICS) for Class II gaming. 77 FR 58708, Sept. 21, 2012. Similar to the part...

  18. 78 FR 78693 - List of Approved Spent Fuel Storage Casks: Transnuclear, Inc. Standardized NUHOMS® Cask System

    Science.gov (United States)

    2013-12-27

    ... RIN 3150-AJ10 List of Approved Spent Fuel Storage Casks: Transnuclear, Inc. Standardized NUHOMS Cask... final rule amended the NRC's spent fuel storage regulations by revising the Transnuclear, Inc. Standardized NUHOMS Cask System listing within the ``List of Approved Spent Fuel Storage Casks'' to...

  19. Introductory Lecture on the Topic "European Standardization System" Given by BSI Officer

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ BSI high officer, Mr. Trevor Vyze, Head of Technical Policy, BSI International Policy, delivered an introductory lecture on the topic "European Standardization System" to the Chinese attendees at a meeting during his visit to the SAC (Standardization Administration of P.R. China) on Nov. 22, 2005.

  20. Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis

    Science.gov (United States)

    Menasria, Rafik; Canivet, Coraline; Piret, Jocelyne; Boivin, Guy

    2015-01-01

    The kinetics and distribution of infiltrating blood monocytes into the central nervous system and their involvement in the cerebral immune response together with resident macrophages, namely microglia, were evaluated in experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE). To distinguish microglia from blood monocyte-derived macrophages, chimeras were generated by conditioning C57BL/6 recipient mice with chemotherapy regimen followed by transplantation of bone morrow-derived cells that expressed the green fluorescent protein. Mice were infected intranasally with a sub-lethal dose of HSV-1 (1.2x106 plaque forming units). Brains were harvested prior to and on days 4, 6, 8 and 10 post-infection for flow cytometry and immunohistochemistry analysis. The amounts of neutrophils (P<0.05) and «Ly6Chi» inflammatory monocytes (P<0.001) significantly increased in the CNS compared to non-infected controls on day 6 post-infection, which corresponded to more severe clinical signs of HSE. Levels decreased on day 8 for both leukocytes subpopulations (P<0.05 for inflammatory monocytes compared to non-infected controls) to reach baseline levels on day 10 following infection. The percentage of «Ly6Clow» patrolling monocytes significantly increased (P<0.01) at a later time point (day 8), which correlated with the resolution phase of HSE. Histological analysis demonstrated that blood leukocytes colonized mostly the olfactory bulb and the brainstem, which corresponded to regions where HSV-1 particles were detected. Furthermore, infiltrating cells from the monocytic lineage could differentiate into activated local tissue macrophages that express the microglia marker, ionized calcium-binding adaptor molecule 1. The lack of albumin detection in the brain parenchyma of infected mice showed that the infiltration of blood leukocytes was not necessarily related to a breakdown of the blood-brain barrier but could be the result of a functional recruitment. Thus, our findings suggest

  1. Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis.

    Directory of Open Access Journals (Sweden)

    Rafik Menasria

    Full Text Available The kinetics and distribution of infiltrating blood monocytes into the central nervous system and their involvement in the cerebral immune response together with resident macrophages, namely microglia, were evaluated in experimental herpes simplex virus 1 (HSV-1 encephalitis (HSE. To distinguish microglia from blood monocyte-derived macrophages, chimeras were generated by conditioning C57BL/6 recipient mice with chemotherapy regimen followed by transplantation of bone morrow-derived cells that expressed the green fluorescent protein. Mice were infected intranasally with a sub-lethal dose of HSV-1 (1.2 x 10(6 plaque forming units. Brains were harvested prior to and on days 4, 6, 8 and 10 post-infection for flow cytometry and immunohistochemistry analysis. The amounts of neutrophils (P < 0.05 and "Ly6C hi" inflammatory monocytes (P < 0.001 significantly increased in the CNS compared to non-infected controls on day 6 post-infection, which corresponded to more severe clinical signs of HSE. Levels decreased on day 8 for both leukocytes subpopulations (P < 0.05 for inflammatory monocytes compared to non-infected controls to reach baseline levels on day 10 following infection. The percentage of "Ly6C low" patrolling monocytes significantly increased (P < 0.01 at a later time point (day 8, which correlated with the resolution phase of HSE. Histological analysis demonstrated that blood leukocytes colonized mostly the olfactory bulb and the brainstem, which corresponded to regions where HSV-1 particles were detected. Furthermore, infiltrating cells from the monocytic lineage could differentiate into activated local tissue macrophages that express the microglia marker, ionized calcium-binding adaptor molecule 1. The lack of albumin detection in the brain parenchyma of infected mice showed that the infiltration of blood leukocytes was not necessarily related to a breakdown of the blood-brain barrier but could be the result of a functional recruitment. Thus

  2. Applying IEEE storage system management standards at the National Storage Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Louis, S.; Hyer, S.W.

    1992-12-04

    Since its inception in 1990, the IEEE Storage System Standards Working Group has identified storage-system management as an area in need of further development The pressing need for standards in storage-system management arises from the requirement to exchange management information and to provide control in a consistent predictable manner between the components of a storage system. An appropriate set of management standards will allow multiple vendors to supply storage management subsystems or applications that are integral to or compatible with new storage systems conforming to future IEEE standards. An early, practical application of IEEE storage-system-management work is being pursued at the National Storage Laboratory (NSL), a recently-formed industrial collaboration at Lawrence Livermore National Laboratory. The NSL`s purpose is to develop advanced hardware and software technologies for high-performance, distributed storage systems. Since storage system management is of critical concern, it is being explored in depth at the NSL. Work was initiated to define basic management requirements and develop generalized graphical-user-interface tools using remote-procedure-call mechanisms to implement the NSL`s conceptual management framework. Several constraints were imposed on the development of early versions of this work to maintain compatibility with the NSL`s underlying UniTree-based software architecture and to provide timely prototypes and proof of concept. The project leverages the on-going standards work of the IEEE Storage System Standards Working Group (SSSWG) and also explores some of the relationships and interactions between IEEE storage-system management and more well known management methods for distributed systems and networks. It will have long term benefits by providing ``real-life`` storage-system-management requirements to the IEEE SSSWG for validation of evolving standards.

  3. Laser Doppler flowmeter study on regional cerebral blood flow in early stage after standard superficial temporal artery-middle cerebral artery bypass surgery for moyamoya disease

    Institute of Scientific and Technical Information of China (English)

    GESANG Dun-zhu; ZHANG Dong; ZHAO Ji-zong; WANG Shuo; ZHAO Yuan-li; WANG Rong; SUN Jian-jun; MENG Ze

    2009-01-01

    Background Standard superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery is an effective treatment for moyamoya disease, but recent evidence suggests that postoperative cerebral hyperperfusion can occur. In this study, the trendline of changes in regional cerebral blood flow (rCBF) after surgery were continually monitored near the site of anastomosis in order to investigate both the efficacy of the procedure for improving rCBF and the possible riskof hyperperfusion.Methods Standard STA-MCA bypass surgery was performed on 13 patients, rCBF was measured continually using laser Doppler flowmetry (LDF) until the 5th day after the operation with the LDF probe implanted adjacent to the area of the anastomosis. The trendline of rCBF changes postoperatively was recorded for the analysis performed using SPSS 13.0.Results The baseline LDF value of cortical rCBF was (84.68±14.39) perfusion unit (PU), which was linear relative to absolute perfusion volume before anastomosis and (88.90±11.26) PU immediately after anastomosis (P >0.05). The value changed significantly from before to after anastomosis (P 0.05).Conclusions STA-MCA anastomosis improves the cerebral blood supply significantly in the early stage after surgery,however, the risk of symptomatic hyperperfusion may exist, which may possibly occur on the 1st day and 5th day after surgery. A LDF is useful for postoperative monitoring for both the efficacy of bypass and possible risk of neurologic deterioration or bleeding from hyperperfusion.

  4. Length of sedimentation reaction in blood: a comparison of the test 1 ESR system with the ICSH reference method and the sedisystem 15.

    Science.gov (United States)

    Romero, Adolfo; Muñoz, Manuel; Ramírez, Gemma

    2003-02-01

    The aim of this study was to compare the performance of the automatic TEST 1 ESR system, SIRE Analytical Systems (TEST 1), with that of the the Sedisystem 15, Becton Dickinson (SEDI), and the International Council for Standardization in Haematology reference method (Westergren) for measuring the length of sedimentation reaction in blood (LSRB). This reaction was measured in 418 paired blood samples drawn in K2-EDTA vacuum tubes and specific tubes from patients scheduled for routine LSRB measurement. The TEST 1 system uses micro-sedimentation and quantitative capillary photometry technology, whereas the SEDI uses a CCD camera. For Westergren, a 200 mm column with 3.0 mm internal diameter was used. Compared to Westergren, TEST 1 gives accurate values of LSRB in most of the samples (mean of differences: 0.99 +/- 10.4 mm; 95% CI, -0.807 to 2.78 mm; n =131). Similar results were obtained in the comparison with SEDI (mean of differences: -0.626 +/- 8 mm; 95% CI, -1.756 to 0.5 mm; n = 195). Compared to those of fresh blood samples, LSRB values were significantly lower in 24 h stored samples, either at 4 degrees C (21.5 +/- 2.3 vs. 19.4 +/- 2.2 mm; p (Spearman's coefficient of correlation): 0.981; n = 44) or at room temperature (19.1 +/- 2.5 vs. 16.2 +/- 2.1 mm; p: 0.903; n = 46). In conclusion, TEST 1 is a rapid, reliable system for automatic measurement of LSRB in standard K2-EDTA blood samples. It has a very low imprecision and maintains a good performance in 24 h stored samples. In addition, due to its operational characteristics (60 samples/20 min) it is a suitable tool for clinical laboratories with a high work load as well as for emergency laboratories. PMID:12667012

  5. Design and Application of Clinical Blood Transfusion Management Information System%临床输血业务管理信息系统的设计与应用

    Institute of Scientific and Technical Information of China (English)

    陈兰; 周湘江; 罗安燕; 彭建

    2014-01-01

    In this paper, a blood transfusion service management subsystem is designed on the basis of the original blood bank management system to realize a integrated management from the blood bank to the clinic. The establishment and application of the management platform achieves informatization and standardization of the whole process of blood transfusion, thus making blood transfusion more effective and reasonable.%本研究在原有的血库管理系统的基础上,设计了输血业务管理信息子系统,以实现血库到临床的业务集成管理。该平台,实现了输血业务全过程的信息化、标准化管理,从而提高了科学用血水平。

  6. Modular Power System Configured with Standard Product Hybrid DC-DC Converters Project

    Data.gov (United States)

    National Aeronautics and Space Administration — VPT proposes an innovative concept whereby complex, multiple-output, DC-DC converter systems can be configured through use of only 2 standard product hybrid DC-DC...

  7. The role of constitution's standards as the integration part of forming of Ukrainian Air law system

    OpenAIRE

    Шереметьєва, Ольга Юріївна; Інститут повітряного і космічного права та масових комунікацій, Національний авіаційний університет

    2015-01-01

    The role and meaning of constitution's standards as the integration part of forming of Air law system are investigatedat the article and also the status of Ukrainian legislation about the air area using.

  8. 40 CFR 63.450 - Standards for enclosures and closed-vent systems.

    Science.gov (United States)

    2010-07-01

    ...-vent systems. 63.450 Section 63.450 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Standards for enclosures and closed-vent systems. (a) Each enclosure and closed-vent system specified in §§ 63.443(c), 63.444(b), and 63.445(b) for capturing and transporting vent streams that contain...

  9. Investigations on international standardization of environmental management systems. 3; Kankyo kanri system no kokusai hyojunka ni kansuru chosa. 3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Japan as an ISO member country identifies the state of discussions in the environmental management standard deliberation committee at ISO. Investigations were performed on international standardization of environmental management systems for the purpose of participating and cooperating in preparing and establishing international standards related to environmental management, and playing part in working, solving and improving environmental problems. Under the circumstances that environmental problems are drawing worldwide interest, the International Organization for Standardization (ISO) has been carrying out since 1993 deliberations on environmental management standards to institutionalize environmental management rules to check effects of business activities on the environment. The International Organization for Standardization/Environmental Management Technical Committee (ISO/TC207) was installed, at which series number of 1400 order was allotted for environmental management related standards, and major standards have come to a final stage of standard formulation at the TC207 Oslo conference in June 1995. In Japan, the Ministry of International Trade and Industry has established an environmental management standard deliberation committee composed of people of experience or academic standing to advance discussions on how the environmental management should be in business entities through deliberations on ISO standards.

  10. A Taxonomy of E-Health Standards to Assist System Developers

    Science.gov (United States)

    Chávez, Emma; Krishnan, Padmanabhan; Finnie, Gavin

    Building e-health systems requires a good understanding of the range and characteristics of many relevant standards. These standards play an important role in the promotion of coordination amongst the key players in the technical and administrative areas of the e-health arena. Many entities including government, information technology professional bodies and medical organizations have developed a large number of e-health standards initiatives. Because of this broad range of initiatives, we propose a classification of standards to simplify the process to find out relevant information. The main objective is to facilitate the retrieval of e-health standards information by limiting the searching of classes or categories based on the applicability that the standards have in particular domains. Thus, we offer a framework to classify documents “standards” by assigning them to a predetermined set of categories and domains.

  11. Management control and status reports documentation standard and Data Item Descriptions (DID). Volume of the information system life-cycle and documentation standards, volume 5

    Science.gov (United States)

    Callender, E. David; Steinbacher, Jody

    1989-01-01

    This is the fifth of five volumes on Information System Life-Cycle and Documentation Standards. This volume provides a well organized, easily used standard for management control and status reports used in monitoring and controlling the management, development, and assurance of informations systems and software, hardware, and operational procedures components, and related processes.

  12. Management plan documentation standard and Data Item Descriptions (DID). Volume of the information system life-cycle and documentation standards, volume 2

    Science.gov (United States)

    Callender, E. David; Steinbacher, Jody

    1989-01-01

    This is the second of five volumes of the Information System Life-Cycle and Documentation Standards. This volume provides a well-organized, easily used standard for management plans used in acquiring, assuring, and developing information systems and software, hardware, and operational procedures components, and related processes.

  13. Study on the standard system of housing and real-estate industry information in China

    Institute of Scientific and Technical Information of China (English)

    尚春明; 王要武; 刘洪玉

    2004-01-01

    Basic standards of information are for all construction work. The formulation for a standard system for housing and real-estate industry information is of great significance to the promotion of the sound development of uniform construction and the transformation of production operations and management mode. This article gives an introduction to the application of information in the housing and real-estate industry, putting forward the consideration and framework for establishing the standard system of housing and the real-estate industry information to meet the needs of actual demands in China.

  14. 25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What are the general financial management system... ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Standards for Financial Management Systems § 900.43 What are the general financial management system standards that apply to a...

  15. 25 CFR 900.42 - What are the general financial management system standards that apply to an Indian tribe carrying...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What are the general financial management system... Standards for Tribal or Tribal Organization Management Systems Standards for Financial Management Systems § 900.42 What are the general financial management system standards that apply to an Indian...

  16. Hollow-Fiber Cartridges: Model Systems for Virus Removal from Blood

    Science.gov (United States)

    Jacobitz, Frank; Menon, Jeevan

    2005-11-01

    Aethlon Medical is developing a hollow-fiber hemodialysis device designed to remove viruses and toxins from blood. Possible target viruses include HIV and pox-viruses. The filter could reduce virus and viral toxin concentration in the patient's blood, delaying illness so the patient's immune system can fight off the virus. In order to optimize the design of such a filter, the fluid mechanics of the device is both modeled analytically and investigated experimentally. The flow configuration of the proposed device is that of Starling flow. Polysulfone hollow-fiber dialysis cartridges were used. The cartridges are charged with water as a model fluid for blood and fluorescent latex beads are used in the experiments as a model for viruses. In the experiments, properties of the flow through the cartridge are determined through pressure and volume flow rate measurements of water. The removal of latex beads, which are captured in the porous walls of the fibers, was measured spectrophotometrically. Experimentally derived coefficients derived from these experiments are used in the analytical model of the flow and removal predictions from the model are compared to those obtained from the experiments.

  17. Blood metabolites and some fertility parameters in dairy cows under intensive management system

    International Nuclear Information System (INIS)

    Dairy farms (1, 2, 3 and 4) of the intensive management system were selected. They are located 50 kilometers south of Khartoum state in a semi-arid zone. The effect of management on some fertility parameters, blood metabolites and minerals were investigated. Changes in blood metabolites with stage of lactation were also monitored. Other parameters studied were body weight, body condition score at calving. The results revealed that days to first P4 rise after calving and number of services per conception (NSPC) were lower in the farm s contained the cross-bred (Fresian X Zebu) compared to the farm contained the pure Fresian breed. The pure Fresian cows showed heavier weights and less body score at calving compared to the cross breed. Blood metabolites reflected the nutritional status of the dairy cows under study, plasma total protein, albumin, globulin, urea and Glucose did not show significant changes either either either between farms or in response to lactation stages. However, high levels of Globulins might indicate inflammation due to some diseases such as mastitis, metritis and lameness. Plasma level of Calcium and Phosphorous did not change significantly either between farms or due to stages of lactation.(Author)

  18. Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier.

    Science.gov (United States)

    Summerfield, Scott G; Zhang, Yanyan; Liu, Houfu

    2016-08-01

    Assessing the equilibration of the unbound drug concentrations across the blood-brain barrier (Kp,uu) has progressively replaced the partition coefficient based on the ratio of the total concentration in brain tissue to blood (Kp). Here, in vivo brain distribution studies were performed on a set of central nervous system (CNS)-targeted compounds in both rats and P-glycoprotein (P-gp) genetic knockout mice. Several CNS drugs are characterized by Kp,uu values greater than unity, inferring facilitated uptake across the rodent blood-brain barrier (BBB). Examples are shown in which Kp,uu also increases above unity on knockout of P-gp, highlighting the composite nature of this parameter with respect to facilitated BBB uptake, efflux, and passive diffusion. Several molecules with high Kp,uu values share common structural elements, whereas uptake across the BBB appears more prevalent in the CNS-targeted drug set than the chemical templates being generated within the current lead optimization paradigm. Challenges for identifying high Kp,uu compounds are discussed in the context of acute versus steady-state data and cross-species differences. Evidently, there is a need for better predictive models of human brain Kp,uu. PMID:27194478

  19. Determination of Rate and Causes of Wastage of Blood and Blood Products in Iranian Hospitals

    Directory of Open Access Journals (Sweden)

    Rafat Mohebbi Far

    2014-06-01

    Full Text Available OBJECTIVE: The purpose of this study was to determine the rate and causes of wastage of blood and blood products (packed red cells, plasma, platelets, and cryoprecipitate in Qazvin hospitals. METHODS: The study was conducted in all hospitals in Qazvin, including 5 teaching hospitals, 2 social welfare hospitals, 3 private hospitals, 1 charity hospital, and 1 military hospital. This descriptive study was based on available data from hospital blood banks in the province of Qazvin. The research instrument was a 2-part questionnaire. The first part was related to demographic characteristics of hospitals and the second part elicited information about blood and blood component wastage. The collected data were then analyzed using descriptive statistic methods and SPSS 11.5. RESULTS: Blood wastage may occur for a number of reasons, including time expiry, wasted imports, blood medically or surgically ordered but not used, stock time expired, hemolysis, or miscellaneous reasons. Data indicated that approximately 77.9% of wasted pack cell units were wasted for the reason of time expiry. Pack cell wastage in hospitals is reported to range from 1.93% to 30.7%. Wastage at all hospitals averaged 9.8% among 30.913 issued blood products. Overall blood and blood product (packed red cells, plasma, platelets, and cryoprecipitate wastage was 3048 units and average total wastage per participant hospital for all blood groups was 254 units per year. CONCLUSION: Blood transfusion is an essential part of patient care. The blood transfusion system has made significant advancements in areas such as donor management, storage of blood, cross-matching, rational use of blood, and distribution. In order to improve the standards of blood banks and the blood transfusion services in Iran, comprehensive standards have been formulated to ensure better quality control in collection, storage, testing, and distribution of blood and its components for the identified major factors

  20. [The response of cerebral blood flow and systemic arterial blood pressure to hypercapnia and hypocapnia in humans].

    Science.gov (United States)

    Kulikov, V P; Kuznetsova, D V

    2013-01-01

    In 11 healthy volunteers 21 +/- 3.7 years old was monitored cerebral blood flow (CBF) by transcranial Doppler (TCD) of middle cerebral artery and mean hemodynamic arterial blood pressure (MAP) by continuous non-invasive measurement "beat-to-beat" at normocapnia, hypercapnia and hypocapnia. Hypercapnia was creating by rebreathing, hypocapnia was creating by spontaneous hyperventilation. The partial pressure of CO2 in alveolar air (PetCO2) was monitored by capnograph, embedded in the TCD-analyzer. During hypercapnia the velocity of CBF and PetCO2 were significantly increased already at 10 s, which was considerably earlier than the increase in the MAP (30 s). During hypocapnia velocity CBF and PetCO2 were significantly decreased at 10 s, and MAP was not changed. We have installed the threshold PetCO2 42 (41; 44) mm Hg, below which amplification CBF occurs at a constant MAP and reflects the true cerebrovascular reactivity to CO2. PMID:23805713

  1. What Causes High Blood Pressure?

    Science.gov (United States)

    ... whether imbalances in this system cause high blood pressure. Blood Vessel Structure and Function Changes in the structure ... can affect blood pressure. Genetic Causes of High Blood Pressure Much of the understanding of the body systems ...

  2. Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice.

    Directory of Open Access Journals (Sweden)

    Karl Swärd

    Full Text Available Caveolae are omega-shaped plasma membrane micro-domains that are abundant in cells of the vascular system. Formation of caveolae depends on caveolin-1 and cavin-1 and lack of either protein leads to loss of caveolae. Mice with caveolin-1 deficiency have dysfunctional blood vessels, but whether absence of cavin-1 similarly leads to vascular dysfunction is not known. Here we addressed this hypothesis using small mesenteric arteries from cavin-1-deficient mice. Cavin-1-reporter staining was intense in mesenteric arteries, brain arterioles and elsewhere in the vascular system, with positive staining of both endothelial and smooth muscle cells. Arterial expression of cavin-1, -2 and -3 was reduced in knockout (KO arteries as was expression of caveolin-1, -2 and -3. Caveolae were absent in the endothelial and smooth muscle layers of small mesenteric arteries as determined by electron microscopy. Arginase, a negative regulator of nitric oxide production, was elevated in cavin-1 deficient arteries as was contraction in response to the α1-adrenergic agonist cirazoline. Detailed assessment of vascular dimensions revealed increased media thickness and reduced distensibility, arguing that enhanced contraction was due to increased muscle mass. Contrasting with increased α1-adrenergic contraction, myogenic tone was essentially absent and this appeared to be due in part to increased nitric oxide production. Vasomotion was less frequent in the knock-out vessels. In keeping with the opposing influences on arterial resistance of increased agonist-induced contractility and reduced myogenic tone, arterial blood pressure was unchanged in vivo. We conclude that deficiency of cavin-1 affects the function of small arteries, but that opposing influences on arterial resistance balance each other such that systemic blood pressure in unstressed mice is well maintained.

  3. Standardized efficiency. Further development of international standardization of efficiency classes of electric motors and drive systems; Genormte Energieeffizienz. Aktuelle Weiterentwicklung der internationalen Normung zu Wirkungsgradklassen von Elektroantrieben

    Energy Technology Data Exchange (ETDEWEB)

    Ponick, Bernd [Hannover Univ. (Germany). Inst. fuer Antriebssysteme und Leistungselektronik

    2011-07-01

    The international standardization of efficiency classes for electric motors and the efficiency legislation of the European Union based on this standardization have already influenced the development of standard motors for industrial applications significantly. On initiative of the European Commission, the next edition of the respective standard, which is currently elaborated, will incorporate also other types of electrical machines into the system of efficiency classes, which is currently restricted to standard cage induction motors. In a parallel standardization project, a new system of efficiency classes for converter fed power drive systems is being developed. These activities have important consequences for the development of new series of electric motors and the further development of electrical drive technology for industrial applications, which are discussed in this paper. (orig.)

  4. Assessment of a continuous blood gas monitoring system in animals during circulatory stress

    Directory of Open Access Journals (Sweden)

    Renzulli Attilio

    2011-01-01

    Full Text Available Abstract Background The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions Methods Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min, vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h, hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia, and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg.Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed. Results Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96; pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96. The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95, Base excess (bias 0.04,precision 0.28, r2 = 0.98, HCO3 (bias 0.05,precision 0.62, r2 = 0.92,hemoglobin (bias 0.02,precision 0.23, r2 = 0.96 and K+ (bias 0.02, precision 0.27, r2 = 0.93. The sensor was reliable throughout the experiment during hemodynamic variations. Conclusions Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.

  5. Fundamental Data Standards for Science Data System Interoperability and Data Correlation

    Science.gov (United States)

    Hughes, J. Steven; Gopala Krishna, Barla; Rye, Elizabeth; Crichton, Daniel

    The advent of the Web and languages such as XML have brought an explosion of online science data repositories and the promises of correlated data and interoperable systems. However there have been relatively few successes in meeting the expectations of science users in the internet age. For example a Google-like search for images of Mars will return many highly-derived and appropriately tagged images but largely ignore the majority of images in most online image repositories. Once retrieved, users are further frustrated by poor data descriptions, arcane formats, and badly organized ancillary information. A wealth of research indicates that shared information models are needed to enable system interoperability and data correlation. However, at a more fundamental level, data correlation and system interoperability are dependant on a relatively few shared data standards. A com-mon data dictionary standard, for example, allows the controlled vocabulary used in a science repository to be shared with potential collaborators. Common data registry and product iden-tification standards enable systems to efficiently find, locate, and retrieve data products and their metadata from remote repositories. Information content standards define categories of descriptive data that help make the data products scientifically useful to users who were not part of the original team that produced the data. The Planetary Data System (PDS) has a plan to move the PDS to a fully online, federated system. This plan addresses new demands on the system including increasing data volume, numbers of missions, and complexity of missions. A key component of this plan is the upgrade of the PDS Data Standards. The adoption of the core PDS data standards by the International Planetary Data Alliance (IPDA) adds the element of international cooperation to the plan. This presentation will provide an overview of the fundamental data standards being adopted by the PDS that transcend science domains and that

  6. Tainted blood

    DEFF Research Database (Denmark)

    Deleuran, Ida; Sheikh, Zainab Afshan; Hoeyer, Klaus

    2015-01-01

    study of the historical rise and current workings of safety practices in the Danish blood system. Here, we identify a strong focus on contamination in order to avoid 'tainted blood', at the expense of working with risks that could be avoided through enhanced blood monitoring practices. Of further...... significance to this focus are the social dynamics found at the heart of safety practices aimed at avoiding contamination. We argue that such dynamics need more attention, in order to achieve good health outcomes in transfusion medicine. Thus, we conclude that, to ensure continuously safe blood systems, we...... need to move beyond the bifurcation of the social and medical aspects of blood supply as two separate issues and approach social dynamics as key medical safety questions....

  7. Are Standards-based Quality Systems a Threat to the Internationalization of Teaching and Learning?

    Directory of Open Access Journals (Sweden)

    Scott Thompson-Whiteside

    2013-05-01

    Full Text Available This paper explores the current shift in Australia’s higher education system moving to a more explicit, standards-based quality system and its potential impact on international partnerships in teaching and learning, particularly in Asia. The new Tertiary Education Quality and Standards Agency and the underlying Higher Education Standards Framework have the potential to threaten a large number of transnational or cross-border programs delivered outside of Australia. With over one hundred and fifty thousand tertiary students studying Australian programs in Asia, the impact could be significant. It would also be significant for countries that leverage of Australian Universities to build human capacity within their country. The paper highlights the current practice of assuring equivalent and comparable academic standards in transnational education and explores how shifting to a more precise standards framework will require more explicit demonstration of standards across teaching, learning and student outcomes. If equivalent or comparable standards were to be achieved across the whole standards framework, it is likely to constrain the opportunities for internationalization and the formation of new transnational partnerships.

  8. An Analysis of Pulsed Wave Ultrasound Systems for Blood Velocity Estimation

    DEFF Research Database (Denmark)

    Jensen, J. A.

    1995-01-01

    of the received signal. The time evolution and distribution of velocity can then be found by using samples from a number of pulse-echo lines. Making a short-time Fourier transform of the data reveals the velocity distribution in the range gate over time. Such systems are called Doppler ultrasound systems implying......Pulsed wave ultrasound systems can be used for determining blood's velocity non-invasively in the body. A region of interest is selected, and the received signal is range gated to measure data from the region. One complex sample value is acquired for each pulse emission after complex demodulation...... and the number of pulse emissions aect the result. The nal equation for the received signal is quite complicated, and a simplied interpretation is therefore also given. This readily reveals the infuence from transducer bandwidth, attenuation, non-linear eects, classical Doppler eect, and scattering....

  9. NIST bullet signature measurement system for RM (Reference Material) 8240 standard bullets.

    Science.gov (United States)

    Ma, Li; Song, John; Whitenton, Eric; Zheng, Alan; Vorburger, Theodore; Zhou, Jack

    2004-07-01

    A bullet signature measurement system based on a stylus instrument was developed at the National Institute of Standards and Technology (NIST) for the signature measurements of NIST RM (Reference Material) 8240 standard bullets. The standard bullets are developed as a reference standard for bullet signature measurements and are aimed to support the recently established National Integrated Ballistics Information Network (NIBIN) by the Bureau of Alcohol, Tobacco and Firearms (ATF) and the Federal Bureau of Investigation (FBI). The RM bullets are designed as both a virtual and a physical bullet signature standard. The virtual standard is a set of six digitized bullet signatures originally profiled from six master bullets fired at ATF and FBI using six different guns. By using the virtual signature standard to control the tool path on a numerically controlled diamond turning machine at NIST, 40 RM bullets were produced. In this paper, a comparison parameter and an algorithm using auto-and cross-correlation functions are described for qualifying the bullet signature differences between the RM bullets and the virtual bullet signature standard. When two compared signatures are exactly the same (point by point), their cross-correlation function (CCF) value will be equal to 100%. The measurement system setup, measurement program, and initial measurement results are discussed. Initial measurement results for the 40 standard bullets, each measured at six land impressions, show that the CCF values for the 240 signature measurements are higher than 95%, with most of them even higher than 99%. These results demonstrate the high reproducibility for both the manufacturing process and the measurement system for the NIST RM 8240 standard bullets. PMID:15317178

  10. Fast Blood Vector Velocity Imaging using ultrasound: In-vivo examples of complex blood flow in the vascular system

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Udesen, Jesper; Gran, Fredrik;

    2008-01-01

    in the superficial branch of the femoral artery during diastole, 3) that retrograde flow was present in the subclavian artery and antegrade in the common carotid artery during diastole, 4) that vortices were formed in the buckets behind the venous valves in both antegrade and retrograde flow, and 5) that secondary......Conventional ultrasound methods for acquiring color flow images of the blood motion are restricted by a relatively low frame rate and angle dependent velocity estimates. The Plane Wave Excitation (PWE) method has been proposed to solve these limitations. The frame rate can be increased, and the 2-D...... speckle tracking between segments in consecutive speckle images. The flow patterns of six bifurcations and two veins were investigated in-vivo. It was shown: 1) that a stable vortex in the carotid bulb was present opposed to other examined bifurcations, 2) that retrograde flow was present...

  11. 21 CFR 640.1 - Whole Blood.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Whole Blood. 640.1 Section 640.1 Food and Drugs... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Whole Blood § 640.1 Whole Blood. The proper name of this product shall be Whole Blood. Whole Blood is defined as blood collected from human donors for...

  12. Design and implementation of a standard framework for KSTAR control system

    International Nuclear Information System (INIS)

    Highlights: • We performed a standardized of control system in KSTAR. • EPICS based software framework is developed for the realization of various control systems. • The applicability of the framework is widened from a simple command dispatcher to the real time application. • Our framework supports the implementation of embedded IOC in FPGA board. - Abstract: Standardization of control system is an important issue in KSTAR which is organized with various heterogeneous systems. Diverse control systems in KSTAR have been adopting new application software since 2010. Development of this software was launched for easy implementation of a data acquisition system but it is extended to as a Standard Framework (SFW) of control system in KSTAR. It is composed with a single library, database, template, and descriptor files. The SFW based controller has common factors. It has non-blocking control command method with a thread. The internal sequence handler makes it can be synchronized with KSTAR experiment. It also has a ring buffer pool mechanism for streaming input data handling. Recently, there are two important functional improvements in the framework. Processor embedded FPGA was proposed as a standard hardware platform for specific application. These are also manipulated by the SFW based embedded application. This approach gives single board system an ability of low level distributed control under the EPICS environments. We also developed a real time monitoring system as a real time network inspection tool in 2012 campaign using the SFW

  13. Speciation of mercury in human whole blood by capillary gas chromatography with a microwave-induced plasma emission detector system following complexometric extraction and butylation.

    Science.gov (United States)

    Bulska, E; Emteborg, H; Baxter, D C; Frech, W; Ellingsen, D; Thomassen, Y

    1992-03-01

    Methyl- and inorganic mercury were extracted from human whole blood samples, as their diethyldithiocarbamate complexes, into toluene and butylated by using a Grignard reagent. The mercury species were then separated by gas chromatography (on a 12 m non-polar DB-1 capillary column) and detected by a microwave-induced plasma atomic emission spectrometric (GC-MPD) system. The accuracy and precision of the proposed method were established by the analysis of Seronorm lyophilized human whole blood standards for methyl- and inorganic mercury. No statistical difference (t-test) between the sum of these two species determined by the GC-MPD based method and the recommended total mercury concentrations in the Seronorm samples was observed. Results for the determination of methyl- and inorganic mercury in 60 controls and 90 previously occupationally exposed (to inorganic mercury) workers are presented to illustrate the practical utility of the proposed method. No significantly elevated inorganic mercury concentrations between the two groups were evident.

  14. Evaluation of Open Geospatial Consortium Standards fur Use In LLNL Geographic Information Systems (GIS)

    Energy Technology Data Exchange (ETDEWEB)

    Walker, H; Chou, R; Chubb, K; Schek, J

    2005-09-28

    The objective of this project is to evaluate existing and emerging Open Geospatial Consortium (OGC) standards for use in LLNL programs that rely heavily on geographic data. OGC standards are intended to facilitate interoperability between geospatial processing systems to avoid duplication of effort, lower development costs, and encourage competition based on improved capability and performance rather than vendor lock-in. Some of these standards appear to be gaining traction in the geospatial data community, the Federal government, DOE and DHS. A serious evaluation of this technology is appropriate at this time due to increasing interest and mandated compliance in the Federal government in some situations. A subset of OGC standards is identified and reviewed with a focus on applications to LLNL programs. Each standard or recommendation reviewed was evaluated in general terms. In addition, for specific programs such as Gen&SIS and NARAC, a specific evaluation was made of several of the standards and how they could be used most effectively. It is also important to evaluate the acceptance of these standards in the commercial arena. The implementation of OGC standards by the largest GIS vendor (ESRI) was reviewed. At present, OGC standards are primary useful in specific situations. More generally, many of the standards are immature and their impact on the government and commercial sectors is unclear. Consequently, OGC and related developments need to be observed. As specific standards or groups of standards mature and establish their relevance, these can also be incorporated in LLNL programs as requirements dictate, especially if open implementations and commercial products are available.

  15. Primo Vascular System Accompanying a Blood Vessel from Tumor Tissue and a Method to Distinguish It from the Blood or the Lymph System

    Directory of Open Access Journals (Sweden)

    Jaekwan Lim

    2013-01-01

    Full Text Available A primo vessel was observed in the abdominal cavity in the lung cancer mouse model, and its function as an extra metastatic path was observed. In this work, we found a primo vessel accompanying a blood vessel emanating from a tumor in the skin. We also presented simple and efficient criteria to distinguish a primo vessel from a blood or a lymph vessel and from a nerve. The criteria for using DAPI and Phalloidin will be useful in clinical situations to find and identify the primo vessels among the blood vessels, lymph vessels, or nerves in the tissue surrounding a tumor such as a melanoma or breast cancer.

  16. Evaluation of low level laser therapy irradiation parameters on rat muscle inflammation through systemic blood cytokines

    Science.gov (United States)

    Mantineo, Matias; Pinheiro, João. P.; Morgado, António M.

    2014-02-01

    Low level laser therapy (LLLT) has been used for inflammation treatment. Here, we evaluate the effect of different doses, using continuous (830 and 980 nm) and pulsed illumination (830 nm), in the treatment of inflammation induced in the gastrocnemius muscle of Wistar rats, through cytokines concentration in systemic blood and histological analysis of muscle tissue. Animals were randomly divided into five groups per wavelength (5 animals per group: 10, 20, 30, 40 and 50 mW) plus a control group. LLLT was applied during five days, with constant exposure time and irradiated area (3 minutes; 0.5026 cm2). Blood was collected on days 0, 3 and 6. TNF-α, IL-1β, IL-2 and IL-6 cytokines were quantified by ELISA. Rats were killed on day 6. Muscle inflammatory cells were counted using optical microscopy. Treatment effects occurred for all applied doses (largest effect at 40 mW: 7.2 J, 14 J/cm2 per irradiation), with reduction of proinflammatory TNF-α, IL-1β and IL-6 cytokines and lower number of inflammatory cells. Results were better for 830 nm. Identical methodology was used with pulsed illumination. Average power (40 mW) and duty cycle were kept constant (80%) at five frequencies (5, 25, 50, 100 and 200 Hz). Treatment effects were observed at higher frequencies, with no significant differences between them. However, the treatment effect was lower than for continuous illumination. LLLT effect on inflammation treatment can be monitored by measuring systemic blood cytokines. A larger treatment effect was observed with continuous illumination, where results seem to be compatible with a biphasic dose response.

  17. The strategic use of standardized information exchange technology in a university health system.

    Science.gov (United States)

    Cheng, Po-Hsun; Chen, Heng-Shuen; Lai, Feipei; Lai, Jin-Shin

    2010-04-01

    This article illustrates a Web-based health information system that is comprised of specific information exchange standards related to health information for healthcare services in National Taiwan University Health System. Through multidisciplinary teamwork, medical and informatics experts collaborated and studied on system scope definition, standard selection challenges, system implementation barriers, system management outcomes, and further expandability of other systems. After user requirement analysis and prototyping, from 2005 to 2008, an online clinical decision support system with multiple functions of reminding and information push was implemented. It was to replace its original legacy systems and serve among the main hospital and three branches of 180-200 clinics and 7,500-8,000 patient visits per day. To evaluate the effectiveness of this system, user surveys were performed, which revealed that the average score of user satisfaction increased from 2.80 to 3.18 on a 4-point scale. Among the items, especially e-learning for training service, courtesy communications for system requests, and courtesy communications for system operations showed statistically significant improvement. From this study, the authors concluded that standardized information exchange technologies can be used to create a brand new enterprise value and steadily obtain more competitive advantages for a prestige healthcare system. PMID:20406119

  18. A quality assurance system based on ISO standards: experience in a radiotherapy department

    International Nuclear Information System (INIS)

    The European radiotherapy society has for many years had a great interest in quality assurance. The EORTC radiotherapy group has put enormous effort into its quality assurance programmes. However, besides programmes for dosimetry and guide-lines for infrastructure, the organisation of a department should also be subject to a quality assurance system. In 1992, in the radiotherapy department in Leiden, a project was started to develop a quality assurance system based on the so-called ISO 9001 quality standards. This paper describes how these standards can be applied to create a quality assurance system in a hospital department

  19. Integrating radiology information systems with healthcare delivery environments using DICOM and HL7 standards.

    Science.gov (United States)

    Blazona, Bojan; Koncar, Miroslav

    2006-01-01

    Integration based on open standards, in order to achieve communication and information interoperability, is one of the key aspects of modern health care information systems. Interoperability presents data and communication layer interchange. In this context we identified the HL7 standard as the world's leading medical Information and communication technology (ICT) standard for the business layer in healthcare information systems and we tried to explore the ability to exchange clinical documents with minimal integrated healthcare information systems (IHCIS) change. We explored HL7 Clinical Document Architecture (CDA) abilities to achieve radiology information system integration (DICOM) to IHCIS (HL7). We introduced the use of WADO service interconnection to IHCIS and finally CDA rendering in widely used Internet explorers. PMID:17108539

  20. 76 FR 22919 - National Institute of Justice Offender Tracking System Standard Workshop

    Science.gov (United States)

    2011-04-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs National Institute of Justice Offender Tracking System Standard Workshop AGENCY: National Institute of Justice, DOJ. ACTION: Notice of Meeting of the NIJ Offender Tracking System...

  1. System Dynamics in Distance Education and a Call to Develop a Standard Model

    Science.gov (United States)

    Shaffer, Steven C.

    2005-01-01

    This paper describes systems dynamics, reviews the literature of uses of systems concepts in distance education (DE), presents a preliminary model, and ends in a call to researchers to contribute to the building of a standard model of DE. (Contains 4 figures.)

  2. 41 CFR 105-71.120 - Standards for financial management systems.

    Science.gov (United States)

    2010-07-01

    ... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems... the financial management system of any applicant for financial assistance as part of a preaward review... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Standards for...

  3. Compact catalytic converter system for future diesel emissions standards; Kompaktes Katalysatorsystem fuer kuenftige Diesel-Emissionsnormen

    Energy Technology Data Exchange (ETDEWEB)

    Harth, Klaus [BASF Corporation, Iselin, NJ (United States)

    2012-09-15

    The Euro 6 emissions standard for diesel passenger cars will broaden the application of exhaust aftertreatment systems that use selective catalytic reduction. This will mean a further increase in the volume and complexity of the exhaust aftertreatment system. BASF has developed a compact integrated catalytic converter that combines the functions of particulate filtration and NO{sub x} reduction in a single unit. (orig.)

  4. An evaluation of adherence to society of pharmacists′ standards care in pharmacy information systems in Iran

    Directory of Open Access Journals (Sweden)

    Sakineh Saghaeiannejad-Isfahani

    2015-01-01

    Conclusions: Based on the findings, in the PISs in the hospitals under study, some standards of the society of pharmacists were ignored. Hence, prior to designing and implementing PIS, a needs analysis is required to increase its users′ motivation to identify the system potentialities and to allow the system development in compliance with the world technology advancement.

  5. 32 CFR 37.710 - What standards do I include for purchasing systems of nonprofit organizations?

    Science.gov (United States)

    2010-07-01

    ... governmental organization. (2) 32 CFR 32.40 through 32.49 if the participant is a nonprofit organization other... systems of nonprofit organizations? 37.710 Section 37.710 National Defense Department of Defense OFFICE OF... standards do I include for purchasing systems of nonprofit organizations? (a) So as not to force...

  6. Blood Clots

    Science.gov (United States)

    ... Index A-Z Blood Clots Blood clots are semi-solid masses of blood that can be stationary (thrombosis) ... treated? What are blood clots? Blood clots are semi-solid masses of blood. Normally, blood flows freely through ...

  7. Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly.

    Science.gov (United States)

    Rubio-Ruiz, María Esther; Pérez-Torres, Israel; Soto, María Elena; Pastelín, Gustavo; Guarner-Lans, Verónica

    2014-11-01

    Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailability, by diminished NO synthesis and/or augmented NO scavenging. (3) Production of vasoconstrictor/vasodilator factor imbalances. (4) Low-grade pro-inflammatory environment. (5) Impaired angiogenesis. (6) Endothelial cell senescence. The aging process in vascular smooth muscle is characterized by: (1) Altered replicating potential. (2) Change in cellular phenotype. (3) Changes in responsiveness to contracting and relaxing mediators. (4) Changes in intracellular signaling functions. Systemic arterial hypertension is an age-dependent disorder, and almost half of the elderly human population is hypertensive. The influence of hypertension on the aging cardiovascular system has been studied in models of hypertensive rats. Treatment for hypertension is recommended in the elderly. Lifestyle modifications, natural compounds and hormone therapies are useful for initial stages and as supporting treatment with medication but evidence from clinical trials in this population is needed. Since all antihypertensive agents can lower blood pressure in the elderly, therapy should be based on its potential side effects and drug interactions.

  8. 34 CFR 403.202 - What must each State's system of core standards and measures of performance include?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What must each State's system of core standards and... system of core standards and measures of performance include? (a) The statewide system of core standards... and competency gains, including student progress in the achievement of basic and more...

  9. Choice of insulation standard for pipe networks in 4th generation district heating systems

    DEFF Research Database (Denmark)

    Lund, Rasmus Søgaard; Mohammadi, Soma

    2016-01-01

    and smart gas grids. Improving DH pipes by improving the insulation standard results in decreasing the heat and temperature losses from the pipe networks. When reducing heat losses from DH pipes, there is a trade-off between the increasing cost of pipe insulation and the associated savings in the heat...... by implementing different pipe insulation standards. In the second step, the specific grid losses found in the first step are analysed in an integrated energy systems model where all main energy sectors and their interrelations are included. The outcome of the study can provide decision support when planning...... investments in DH systems today and in the future. The results from the case of Denmark shows that pipes with higher insulation standard (series 3) is generally preferable, but the highest insulation standard available today (series 4) might be preferable in the future if fuel prices or increase or investment...

  10. ETSI reconfigurable radio systems : Status and future directions on software defined radio and cognitive radio standards

    OpenAIRE

    Mueck M.; Piipponen A.; Kalliojarvi K.; Dimitrakopoulos G.; Tsagkaris K.; Demestichas P.; Casadevall F.; Perez-Romero J.; Sallent O.; Baldini G.

    2010-01-01

    Feature Topic on Advances in IEEE Standards and Testbeds for Cognitive Radio Networks International audience This article details the current work status of the ETSI Reconfigurable Radio Systems Techni- cal Committee, positions the ETSI work with respect to other standards efforts (IEEE 802, IEEE SCC41) as well as the European Regula- tory Framework, and gives an outlook on the future evolution. In particular, software defined radio related study results are presented with a focus on SD...

  11. Oximetry system performance assessment with POM (acetal) phantoms incorporating hemoglobin calibration standards and customized saturation levels

    Science.gov (United States)

    Jang, Hyounguk; Singh, Karam; Wang, Hsing-Wen; Pfefer, T. J.; Chen, Yu

    2015-03-01

    Standardized approaches for performance assessment of biophotonic devices have the potential to facilitate system development and intercomparison, clinical trial standardization, recalibration, manufacturing quality control and quality assurance during clinical use. Evaluation of devices based on near-infrared spectroscopy (NIRS) for detection of hemoglobin (Hb) content and oxygenation have often involved tissue-simulating phantoms incorporating artificial dyes or flow systems. Towards the development of simple, effective techniques for objective, quantitative evaluation of basic NIRS system performance, we have developed and evaluated two test methods. These methods are based on cuvette inserts in solid turbid phantoms for measuring commercially-available Hb oximetry standards and custom-formulated oxy/deoxy-Hb solutions. Both approaches incorporate solid acetal, or polyoxymethylene (POM), as a tissue-simulating matrix material. First, inverse-adding-doubling (IAD) based on measurements with a spectrophotometer and an integrating sphere was used to measure POM optical properties and their stability over time. Second, two fiberopticprobe- based NIRS systems were used to measure concentration change of oxy- and deoxy-Hb in standard Hb solutions and customized Hb solutions by adding yeast. Differences in system performance were likely due to differences in light source outputs and fiberoptic probe design. Our preliminary results indicate that simple phantom-based approaches based on commercially available polymers and inclusions containing Hb standards, or controlled oxygenation levels may be useful for benchtop assessment of NIRS device quality for a variety of biophotonic devices.

  12. Functional state of rat cardiomyocytes and blood antioxidant system under psycho-emotional stress

    Institute of Scientific and Technical Information of China (English)

    Zurab Kuchukashvili; Ketevan Menabde; Matrona Chachua; George Burjanadze; Manana Chipashvili; Nana Koshoridze

    2011-01-01

    We studied the functionality of the antioxidant system in laboratory rat cardiomyocytes and blood under psychoemotional stress.It was found that 40-day isolation and violation of diurnal cycle among the animals were accompanied by the intensification of lipid peroxidation process and marked with a reduced activity of antioxidant system enzymes, such as catalase and superoxide dismutase activity.The results suggested that psycho-emotional stress was accompanied by oxidative stress, causing a reduction in the intensity of energy metabolism in cardiomyocytes, which was further strengthened by the fact that the activity of the enzymes involved in ATP synthesis in mitochondria was reduced.Based on the results, we proposed that psychological stress is one of the factors contributing to the development of various cardiac diseases.

  13. Portable point-of-care blood analysis system for global health (Conference Presentation)

    Science.gov (United States)

    Dou, James J.; Aitchison, James Stewart; Chen, Lu; Nayyar, Rakesh

    2016-03-01

    In this paper we present a portable blood analysis system based on a disposable cartridge and hand-held reader. The platform can perform all the sample preparation, detection and waste collection required to complete a clinical test. In order to demonstrate the utility of this approach a CD4 T cell enumeration was carried out. A handheld, point-of-care CD4 T cell system was developed based on this system. In particular we will describe a pneumatic, active pumping method to control the on-chip fluidic actuation. Reagents for the CD4 T cell counting assay were dried on a reagent plug to eliminate the need for cold chain storage when used in the field. A micromixer based on the active fluidic actuation was designed to complete sample staining with fluorescent dyes that was dried on the reagent plugs. A novel image detection and analysis algorithm was developed to detect and track the flight of target particles and cells during each analysis. The handheld, point-of-care CD4 testing system was benchmarked against clinical cytometer. The experimental results demonstrated experimental results were closely matched with the flow cytometry. The same platform can be further expanded into a bead-array detection system where other types of biomolecules such as proteins can be detected using the same detection system.

  14. NASA-STD-3001, Space Flight Human-System Standard and the Human Integration Design Handbook

    Science.gov (United States)

    Whitmore, Mihriban; Boyer, Jennifer; Holubec, Keith

    2012-01-01

    NASA-STD-3001 Space Flight Human-System Standard Volume 1, Crew Health, Volume 2, Human Factors, Habitability and Environmental Health, and the Human Integration Design Handbook (HIDH) have replaced the Man-Systems Integration Standards (MSIS), NASA-STD-3000. For decades, NASA-STD-3000 was a significant contribution to human spaceflight programs and to human-systems integration. However, with research program and project results being realized, advances in technology, and the availability of new information in a variety of topic areas, the time had arrived to update this extensive suite of standards and design information. NASA-STD-3001, Volume 2 contains the Agency level standards from the human and environmental factors disciplines that ensure human spaceflight operations are performed safely, efficiently, and effectively. The HIDH is organized in the same sequence and serves as the companion document to NASA-STD-3001, Volume 2, providing a compendium of human spaceflight history and knowledge. The HIDH is intended to aid interpretation of NASA-STD-3001, Volume 2 standards and to provide guidance for requirement writers and vehicle and habitat designers. Keywords Human Factors, Standards, Environmental Factors, NASA

  15. Concept for an International Standard related to Space Weather Effects on Space Systems

    Science.gov (United States)

    Tobiska, W. Kent; Tomky, Alyssa

    There is great interest in developing an international standard related to space weather in order to specify the tools and parameters needed for space systems operations. In particular, a standard is important for satellite operators who may not be familiar with space weather. In addition, there are others who participate in space systems operations that would also benefit from such a document. For example, the developers of software systems that provide LEO satellite orbit determination, radio communication availability for scintillation events (GEO-to-ground L and UHF bands), GPS uncertainties, and the radiation environment from ground-to-space for commercial space tourism. These groups require recent historical data, current epoch specification, and forecast of space weather events into their automated or manual systems. Other examples are national government agencies that rely on space weather data provided by their organizations such as those represented in the International Space Environment Service (ISES) group of 14 national agencies. Designers, manufacturers, and launchers of space systems require real-time, operational space weather parameters that can be measured, monitored, or built into automated systems. Thus, a broad scope for the document will provide a useful international standard product to a variety of engineering and science domains. The structure of the document should contain a well-defined scope, consensus space weather terms and definitions, and internationally accepted descriptions of the main elements of space weather, its sources, and its effects upon space systems. Appendices will be useful for describing expanded material such as guidelines on how to use the standard, how to obtain specific space weather parameters, and short but detailed descriptions such as when best to use some parameters and not others; appendices provide a path for easily updating the standard since the domain of space weather is rapidly changing with new advances

  16. Interworking and integration of the Inmarsat Standard-M with Pan-European GSM system

    Science.gov (United States)

    Tafazolli, R.; Evans, B. G.

    The market demand on mobile telephone communications has been increasing since the introduction of the cellular mobile telephone systems about twelve years ago. In Europe, projections indicate a demand of about 17 million subscribers for a fully deployed Pan European system. The Pan-European GSM system is to harmonize the growth of the terrestrial mobile system. Studies conducted by the European Space Agency (ESA) indicate that even with 60-70 percent of the area being covered by the GSM, a significant traffic demand (voice and data) will still exist for areas not covered by the terrestrial systems. This demand could be satisfied by a land mobile satellite system. The satellite system is therefore seen in a complementary role rather than in competition with the terrestrial system in an integrated telecommunications network. One possible scenario may be that initially the satellite system provides services to the rural areas together with areas still not covered by the GSM system. This service area is then gradually diminished as the terrestrial system expands until an optimum point is reached where the systems co-exist optimally. The objective of this paper is to investigate the possibility of integration of a space based system, in this case Inmarsat Standard-M, with the GSM (Global System for Mobile communications). One very important advantage of incorporating GSM services in Standard-M is that it will be feasible to extend the GSM services economically worldwide, not only to land mobiles but also to aeronautical and maritime mobiles.

  17. Technical evaluation of vehicle ignition systems: conduct differences between a high energy capacitive system and a standard inductive system

    Directory of Open Access Journals (Sweden)

    Bruno Santos Goulart

    2014-09-01

    Full Text Available An efficient combustion depends on many factors, such as injection, turbulence and ignition characteristics. With the improvement of internal combustion engines the turbulence intensity and internal pressure have risen, demanding more efficient and powerful ignition systems. In direct injection engines, the stratified charge resultant from the wall/air-guided or spray-guided system requires even more energy. The Paschen’s law shows that spark plug gap and mixture density are proportional to the dielectric rupture voltage. It is known that larger spark gaps promote higher efficiency in the internal combustion engines, since the mixture reaction rate rises proportionally. However, the ignition system must be adequate to the imposed gap, not only on energy, but also on voltage and spark duration. For the reported study in this work two test benches were built: a standard inductive ignition system and a capacitive discharge high energy ignition system, with variable voltage and capacitance. The influence of the important parameters energy and ignition voltage on the spark duration, as well as the electrode gap and shape were analyzed. It was also investigated the utilization of a coil with lower resistance and inductance values, as well as spark plugs with and without internal resistances.

  18. Applying the Australian and New Zealand Risk Management Standard to Information Systems in SMES

    OpenAIRE

    Robyn Davidson; Susan Lambert

    2004-01-01

    This paper advocates the use of the Australia/New Zealand Risk Management Standard (SA/SNZ, 1999) in conjunction with of a modified version of Birch and McEvoy’s (1992) Structured Risk Analysis for Information Systems (SRA-IS) to identify information systems security risks in SMEs. The use of Internet based commerce by SMEs exposes them to information systems security risks that they are ill equipped to recognise let alone mitigate. Unlike the identification of some business risks, identifica...

  19. Development of Skill Standards and a Tailor-made Education System in TOSHIBA

    Science.gov (United States)

    Harashima, Shuji

    Software development for embedded systems such as cellular phone and digital TV systems has become larger in scale while development times have become shorter. More over, the necessary technologies are required to respond more rapidly in line with movements in the sales climate for these products. In such a business environment, skill enhancement for software engineers is highly important. In this paper, we explain a tailor-made education system based on skill standards.

  20. Quality Management System according to the family of Cuban Standards ISO 9000 CN Total Quality approach.

    OpenAIRE

    Leonel C. Alfaro Pérez; Reina A. Carballé Piñón

    2009-01-01

    In this article we develop some considerations and suggestions for organizations in Cuba who want to design and implement systems with Quality Management Total Quality approach to the family of Cuban Standards ISO 9000 CN. It makes a comparative analysis between what is a System of Quality Management, Total Quality and the European model of quality management, detailing the similarities and differences, which allow us to understand how systems can be designed and managed focuses on Total Qual...