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Sample records for blood loss tells

  1. Measuring and communicating blood loss during obstetric hemorrhage.

    Science.gov (United States)

    Gabel, Kristi T; Weeber, Tracy A

    2012-01-01

    Accurate quantification of blood loss is an essential skill necessary to prevent maternal morbidity and mortality associated with obstetric hemorrhage. Visual estimation of blood has been consistently shown to be extremely inaccurate. The nurse plays a pivotal role in quantifying blood loss after birth, recognizing triggers, mobilizing needed interventions, and providing essential communication. PMID:22548283

  2. Factors influencing intraoperative blood loss in orthognathic surgery.

    Science.gov (United States)

    Thastum, M; Andersen, K; Rude, K; Nørholt, S E; Blomlöf, J

    2016-09-01

    This retrospective study aimed to identify factors of importance for intraoperative blood loss relative to total blood volume in patients undergoing orthognathic surgery. The study included 356 patients treated consecutively at a Danish university hospital between 1 January 2010 and 31 December 2012. Inclusion criteria were (1) patient age ≥18 years and (2) patient undergoing a three-piece Le Fort I osteotomy, a bilateral sagittal split osteotomy, or a combination of the two. The patient-specific relative blood loss was calculated as a percentage by dividing the intraoperative blood loss by the estimated preoperative total blood volume, and then correlated with body mass index (BMI), age, sex, operating time, and treatment modality in a multivariate stepwise regression analysis. Operating time (Psurgery, a prolonged operating time, and reduced BMI significantly increase the intraoperative relative blood loss in patients undergoing orthognathic surgery.

  3. Management of major blood loss: an update

    DEFF Research Database (Denmark)

    Johansson, P I; Ostrowski, S R; Secher, N H

    2010-01-01

    the early control of the cause of bleeding by non-definitive means, while haemostatic control resuscitation seeks early control of coagulopathy. Haemostatic resuscitation provides transfusions with plasma and platelets in addition to red blood cells (RBCs) in an immediate and sustained manner as part...... of the transfusion protocol for massively bleeding patients. Transfusion of RBCs, plasma and platelets in a similar proportion as in whole blood prevents both hypovolaemia and coagulopathy. Although an early and effective reversal of coagulopathy is documented, the most effective means of preventing coagulopathy....... Furthermore, viscoelastic whole blood assays, such as thrombelastography (TEG)/rotation thromboelastometry (ROTEM), appear advantageous for identifying coagulopathy in patients with severe haemorrhage, as opposed to conventional coagulation assays. In our view, patients with uncontrolled bleeding, regardless...

  4. Faecal blood loss in response to exercise.

    OpenAIRE

    Robertson, J D; Maughan, R J; Davidson, R J

    1987-01-01

    Recently qualitative tests have indicated that gastrointestinal bleeding during exercise may be an important contributory factor in sports anaemia. In six healthy men who walked 37 km on four consecutive days faecal haemoglobin content remained normal (reference range 0.10-2.53 mg/g faeces) with no significant differences between values. In 28 marathon runners who refrained from taking drugs or food containing blood the median faecal haemoglobin content increased by 0.42 mg/g faeces (95% conf...

  5. Managing anemia and blood loss in elective gynecologic surgery patients.

    Science.gov (United States)

    Rock, W A; Meeks, G R

    2001-05-01

    Hysterectomy is the second-most-common surgical procedure among premenopausal women. The conditions that lead to the need for a hysterectomy often are accompanied by chronic blood loss that can lead to anemia. Moreover, hysterectomy and myomectomy may result in significant blood loss, which exacerbates the anemia. The presence of fatigue associated with anemia has a substantially negative impact on quality of life and the ability to perform activities of daily living. Options for alleviating perioperative anemia include minimizing surgical blood loss, blood transfusion, supplementation with hematinics, such as iron and folic acid, and treatment with recombinant human erythropoietin. Treating preoperative anemia is expected to help correct anemia prior to surgery and may have a positive impact on anemia-related symptoms and surgical outcomes.

  6. Effect of autologous blood donation on the central venous pressure, blood loss and blood transfusion during living donor left hepatectomy

    Institute of Scientific and Technical Information of China (English)

    Bruno Jawan; Shih-Hor Wang; Chih-Che Lin; Tsan-Shiun Lin; Yueh-Wei Liu; Chao-Long Chen; Yu-Fan Cheng; Chia-Chi Tseng; Yaw-Sen Chen; Chih-Chi Wang; Tung-Liang Huang; Hock-Liew Eng; Po-Ping Liu; King-Wah Chiu

    2005-01-01

    AIM: Autologous blood donation (ABD) is mainly used to reduce the use of banked blood. In fact, ABD can be regarded as acute blood loss. Would ABD 2-3 d before operation affect the CVP level and subsequently result in less blood loss during liver resection was to be determined.METHODS: Eighty-four patients undergoing living donor left hepatectomy were retrospectively divided as group Ⅰ (GⅠ)and group Ⅱ (GⅡ) according to have donated 250-300 mL blood 2-3 d before living donor hepatectomy or not. The changes of the intraoperative CVP, surgical blood loss,blood products used and the changes of perioperative hemoglobin (Hb) between groups were analyzed and compared by using Mann-Whitney Utest.RESULTS: The results show that the intraoperative CVP changes between GⅠ (n = 35) and GⅡ (n = 49) up to graft procurement were the same, subsequently the blood loss,but ABD resulted in significantly lower perioperative Hb levels in GⅠ.CONCLUSION: Since none of the patients required any blood products perioperatively, all the predonated bloods were discarded after the patients were discharged from the hospital, It indicates that ABD in current series had no any beneficial effects, in term of cost, lowering the CVP, blood loss and reduce the use of banked blood products, but resulted in significant lower Hb in perioperative period.

  7. [Blood loss in dialysis in repeatedly used capillary dialysators].

    Science.gov (United States)

    Schmidt, U; Senf, L; Kleinert, P; Thieler, H; Marx, M

    1980-11-01

    The blood losses increase to the twofold to threefold by capillary dialysators C-DAK 4 and C-DAK 5 are about 6.8 ml and 26 ml, respectively, in the first use. In repeated use of the C-DAK 4 the blood losses by the C-DAK 5, however, are so high that it is not to be advised to use them manifold under our conditions of dialysis. By an increase of the reperfusion quantity from 150 to 250 ml of electrolyte solution for one C-DAK 4 blood losses may considerably be reduced. In a parallel switching of two C-DAK 4 each exemplar should be perfused individually.

  8. Low central venous pressure reduces blood loss in hepatectomy

    Institute of Scientific and Technical Information of China (English)

    Wei-Dong Wang; Li-Jian Liang; Xiong-Qing Huang; Xiao-Yu Yin

    2006-01-01

    AIM: To investigate the effect of low central venous pressure (LCVP) on blood loss during hepatectomy for hepatocellular carcinoma (HCC).METHODS: By the method of sealed envelope,50 HCC patients were randomized into LCVP group (n = 25) and control group (n = 25). In LCVP group,CVP was maintained at 2-4 mmHg and systolic blood pressure (SBP) above 90 mmHg by manipulation of the patient's posture and administration of drugs during hepatectomy, while in control group hepatectomy was performed routinely without lowering CVP. The patients'preoperative conditions, volume of blood loss during hepatectomy, volume of blood transfusion, length of hospital stay, changes in hepatic and renal functions were compared between the two groups.RESULTS: There were no significant differences in patients' preoperative conditions, maximal tumor dimension, pattern of hepatectomy, duration of vascular occlusion, operationtime, weight of resected liver tissues, incidence of post-operative complications, hepatic and renal functions between the two groups. LCVP group had a markedly lower volume of total intraoperative blood loss and blood loss during hepatectomy than the control group, being 903.9±180.8 mL vs 2 329.4±2 538.4(W=495.5, P<0.01) and 672.4±429.9 mL vs1 662.6± 1932.1 (W=543.5, P<0.01). There were no remarkable differences in the pre-resection and post-resection blood losses between the two groups. The length of hospital stay was significantly shortened in LCVP group as compared with the control group, being 16.3±6.8 d vs21.5 ± 8.6 d (W= 532.5, P<0.05).CONCLUSION: LCVP is easily achievable in technique.Maintenance of CVP≤4 mmHg can help reduce blood loss during hepatectomy, shorten the length of hospital stay, and has no detrimental effects on hepatic or renal function.

  9. Intraoperative blood loss and blood transfusion requirements in patients undergoing orthognathic surgery.

    Science.gov (United States)

    Faverani, Leonardo Perez; Ramalho-Ferreira, Gabriel; Fabris, André Luis Silva; Polo, Tárik Ocon Braga; Poli, Guilherme Henrique Souza; Pastori, Cláudio Maldonado; Marzola, Clóvis; Assunção, Wirley Gonçalves; Garcia-Júnior, Idelmo Rangel

    2014-09-01

    Procedures for the surgical correction of dentofacial deformities may produce important complications, whether due to the potential for vascular injury or to prolonged surgery, both of which may lead to severe blood loss. Fluid replacement with crystalloid, colloid, or even blood products may be required. The aim of this study was to assess blood loss and transfusion requirements in 45 patients (18 males and 27 females; mean age 29.29 years, range 16-52 years) undergoing orthognathic surgery, assigned to one of two groups according to procedure type-rapid maxillary expansion or double-jaw orthognathic surgery. Preoperative hemoglobin and hematocrit levels and intraoperative blood loss were measured. There was a substantial individual variation in pre- and postoperative hemoglobin values (10.3-17 and 8.8-15.4 g/dL, respectively; p surgery and follow meticulous protocols to minimize the risks.

  10. Tranexamic acid reduces the blood loss and blood transfusion requirements following peri-acetabular osteotomy.

    Science.gov (United States)

    Wassilew, G I; Perka, C; Janz, V; Krämer, M; Renner, L

    2015-12-01

    We have investigated the effect of using tranexamic acid (TXA) during peri-acetabular osteotomy (PAO) on peri-operative blood loss and blood transfusion requirements. In addition we analysed whether the use of TXA was associated with an increased risk of venous thromboembolism (VTE) following this procedure. A consecutive series of 96 PAOs, performed by a single surgeon, were reviewed. A total of 48 patients received TXA and 48 did not. The TXA group received a continuous infusion of TXA at a rate of 10 mg/kg/h. The primary outcome measure was the requirement for blood transfusion. Secondary outcomes included total blood loss, the decrease in the level of haemoglobin in the blood, the length of hospital stay, and the complications of this treatment. The mean rate of transfusion was significantly lower in the TXA group (62.5% vs 12.5%, p transfusion after PAO significantly, without adverse effects such as an increased rate of VTE.

  11. Analysis on hidden blood loss of total knee arthroplasty in treating knee osteoarthritis

    Institute of Scientific and Technical Information of China (English)

    SHEN Hui-liang; LI Zheng; FENG Ming-li; CAO Guang-le

    2011-01-01

    Background Total knee arthroplasty (TKA) is an important therapy for the treatment of various late-stage knee diseases. However, it has been observed that patients have lower hemoglobin (HB) counts postoperatively, which are significantly inconsistent with the measured blood loss. Although the concept of hidden blood loss has been presented in 2000, very little clinical attention has been paid since then. In this study, we investigated the characteristics and influential factor of hidden blood loss after TKA in treating knee osteoarthritis.Methods One hundred and eight patients, with 42 males and 66 females, were retrospectively analyzed. The perioperative blood loss and the hidden blood loss following TKA were calculated by Gross formula. Potential factors affecting perioperative and hidden blood loss included gender, surgical time, tourniquet time, hemostasis (during operation with deflating tourniquet), and reinfusion of salvaged blood.Results The average perioperative blood loss was found to be (1553±356) ml and the average hidden blood loss was (793±223) ml. The hidden blood loss of the male was significantly higher than that of the female, and was reduced by hemostasis during the operation with a deflating tourniquet. Hidden blood loss was not affected by postoperative blood salvage and reinfusion, surgical time, or tourniquet time.Conclusions When calculating the value of hidden blood loss by Gross formula, the lowest value of hematocrit should be chosen as the parameter so that hidden blood loss would not be underestimated. No significant differences could be found in hidden blood loss for males compared to females. Hidden blood loss can be reduced by hemostasis during operation with a deflating tourniquet. Although reinfusion of salvaged blood could not reduce the perioperative blood loss or hidden blood loss, it was still an effective method to reduce transfusion rate.

  12. Loss of deformability of malaria-infected red blood cells

    Science.gov (United States)

    Hosseini, S. Majid; Feng, James

    2012-11-01

    The pathogenesis of malaria is largely due to stiffening of the infected red blood cells (RBCs). Contemporary understanding ascribes the loss of RBC deformability to a 10-fold increase in membrane stiffness caused by extra cross-linking in the spectrin network. Local measurements by micropipette aspiration, however, have reported only an increase of 3-fold in the shear modulus. We believe the discrepancy stems from the rigid parasite particles inside infected cells, and have carried out numerical simulations to demonstrate this mechanism. The cell membrane is represented by a set of discrete particles connected by linearly elastic springs. The cytosol is modeled as a homogeneous Newtonian fluid, and discretized by particles as in standard smoothed particle hydrodynamics. The malaria parasite is modeled as an aggregate of particles constrained to rigid-body motion. We simulate RBC stretching tests by optical tweezers in three dimensions. The results demonstrate that the presence of a sizeable parasite greatly reduces the ability of RBCs to deform under stretching. With the solid inclusion, the observed loss of deformability can be predicted quantitatively using the local membrane elasticity measured by micropipettes.

  13. Tranexamic Acid in a Multimodal Blood Loss Prevention Protocol to Decrease Blood Loss in Revision Total Knee Arthroplasty: A Cohort Study#

    Science.gov (United States)

    Ortega-Andreu, Miguel; Talavera, Gloria; Padilla-Eguiluz, Norma G.; Perez-Chrzanowska, Hanna; Figueredo-Galve, Reyes; Rodriguez-Merchán, Carlos E.; Gómez-Barrena, Enrique

    2016-01-01

    Purpose: To clarify if blood loss and transfusion requirements can be decreased in revision knee surgery through a multimodal blood loss approach with tranexamic acid (TXA) Patients and Methods: A retrospective study was designed in 87 knees (79 patients) that received a knee revision between 2007 and 2013. To avoid heterogeneity in the surgical technique, only revisions with one single implant system were included. A treatment series of 44 knees that received TXA and other techniques in a multimodal blood loss protocol was compared to a control series of 43 knees that received neither TXA nor the rest of the multimodal blood loss protocol. No differences in the complexity of surgeries or case severity were detected. Results: A significant decrease was observed from 58% transfusion rate in the control group to 5% in the treated group. The postoperative haemoglobin drop was also significantly different. Although the use of a blood loss prevention approach including TXA was the most relevant factor in the transfusion risk (OR=15), longer surgical time also associated an increased risk of transfusion (OR=1.15). Conclusion: This study supports the use of a two-dose intravenous TXA under a multimodal blood loss prevention approach in revision knee replacement with significant reduction in the transfusion rate, postoperative blood loss and haemoglobin drop.

  14. Comparison of coagulation factors and blood loss between O and non-O blood types following hydroxyethyl starch infusion

    OpenAIRE

    Choi, Soo Joo; Ahn, Hyun Joo; Lee, Jae Ik

    2010-01-01

    Background Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts. Hydroxyethyl starch (HES), which is widely used for blood volume replacement, can induce coagulopathy. Therefore, we tested whether blood type O patients show more coagulopathy and blood loss than non-O patients after infusion of 6% HES. Methods Thirty-four non-O and 20 type O patients scheduled for posterior lumbar interbody fusion (PLIF)...

  15. Pictorial estimation of blood loss in a birthing pool--an aide memoire.

    Science.gov (United States)

    Goodman, Anushia

    2015-04-01

    The aim of this article is to share some photographic images to help midwives visually estimate blood loss at water births. PubMed, CINAHL and MEDLINE databases were searched for relevant research. There is little evidence to inform the practice of visually estimating blood loss in water, as discussed further on in the article. This article outlines a simulation where varying amounts of blood were poured into a birthing pool, captured by photo images. Photo images of key amounts like 150mls, 300mls and 450mls can be useful visual markers when estimating blood loss at water births. The speed of spread across the pool may be a significant factor in assessing blood loss. The author recommends that midwives and educators embark on similar simulations to inform their skill in estimating blood loss at water births.

  16. Safe surgery: how accurate are we at predicting intra-operative blood loss?

    LENUS (Irish Health Repository)

    2012-02-01

    Introduction Preoperative estimation of intra-operative blood loss by both anaesthetist and operating surgeon is a criterion of the World Health Organization\\'s surgical safety checklist. The checklist requires specific preoperative planning when anticipated blood loss is greater than 500 mL. The aim of this study was to assess the accuracy of surgeons and anaesthetists at predicting intra-operative blood loss. Methods A 6-week prospective study of intermediate and major operations in an academic medical centre was performed. An independent observer interviewed surgical and anaesthetic consultants and registrars, preoperatively asking each to predict expected blood loss in millilitre. Intra-operative blood loss was measured and compared with these predictions. Parameters including the use of anticoagulation and anti-platelet therapy as well as intra-operative hypothermia and hypotension were recorded. Results One hundred sixty-eight operations were included in the study, including 142 elective and 26 emergency operations. Blood loss was predicted to within 500 mL of measured blood loss in 89% of cases. Consultant surgeons tended to underestimate blood loss, doing so in 43% of all cases, while consultant anaesthetists were more likely to overestimate (60% of all operations). Twelve patients (7%) had underestimation of blood loss of more than 500 mL by both surgeon and anaesthetist. Thirty per cent (n = 6\\/20) of patients requiring transfusion of a blood product within 24 hours of surgery had blood loss underestimated by more than 500 mL by both surgeon and anaesthetist. There was no significant difference in prediction between patients on anti-platelet or anticoagulation therapy preoperatively and those not on the said therapies. Conclusion Predicted intra-operative blood loss was within 500 mL of measured blood loss in 89% of operations. In 30% of patients who ultimately receive a blood transfusion, both the surgeon and anaesthetist significantly underestimate

  17. Tranexamic acid reduces blood loss in patients with extracapsular fractures of the hip

    DEFF Research Database (Denmark)

    Tengberg, P T; Foss, N B; Palm, H;

    2016-01-01

    AIMS: We chose unstable extra-capsular hip fractures as our study group because these types of fractures suffer the largest blood loss. We hypothesised that tranexamic acid (TXA) would reduce total blood loss (TBL) in extra-capsular fractures of the hip. PATIENTS AND METHODS: A single-centre plac...

  18. Increased blood loss in upright birthing positions originates from perineal damage

    NARCIS (Netherlands)

    Jonge, A. de; Diem, M.T. van; Scheepers, P.L.H.; Pal-de Bruin, K.M. van der; Lagro-Janssen, A.

    2007-01-01

    Objective: To assess whether the risk of severe blood loss is increased in semi-sitting and sitting position, and if so, to which extent blood loss from perineal damage is responsible for this finding. Design: Secondary analysis of data from a large trial. Setting: Primary care midwifery practices i

  19. Surgeons often underestimate the amount of blood loss in replacement surgeries

    Directory of Open Access Journals (Sweden)

    Ram Ganesan Ganesan

    2014-07-01

    Full Text Available 【Abstract】Objective:To assess the accuracy of the clinically estimated blood loss (EBL when compared with the actual blood loss (ABL in replacement surgeries. Methods: This prospective study was done in Sri Ramachandra Medical Centre from April 2011 to April 2013. Altogether 140 patients undergoing total hip replacement or total knee replacement were included with the inclusion criteria being patients with haemoglobin higher than 100 g/ml and coagulation profile within normal limits. Exclusion criteria were intake of antiplatelet drug or anti-coagulant, bleeding disorders, thrombotic episode, and haematological disorders. There were 65 men and 75 women. In this study, the consultants were free to use any clinical method to estimate the blood loss, including counting the blood-soaked mops and gauze pieces (estimating the volume of blood carried in all the mops and gauzes, measuring blood lost to suction bottles and blood in and around the operative field. The ABL was calculated based on a modification of the Gross’s formula using haematocrit values. Results: In 42 of the 140 cases, the EBL exceeded the ABL. These cases had a negative difference in blood loss (or DIFF-BL<0 and were included in the overestimation group, which accounted for 30% of the study population. Of the remaining 98 cases (70%, the ABL exceeded the EBL. Therefore they were put into the underestimation group who had a positive difference in blood loss (DIFF-BL>0. We found that when the average blood loss was small, the accuracy of estimation was high. But when the average blood loss exceeded 500 ml, the accuracy rate decreased significantly. This suggested that clinical estimation is inaccurate with the increase of blood loss. Conclusion:This study has shown that using clinical estimation alone to guide blood transfusion is inadequate. In this study, 70% of patients had their blood loss underestimated, proving that surgeons often underestimate blood loss in replacement

  20. Surgeons often underestimate the amount of blood loss in replacement surgeries

    Institute of Scientific and Technical Information of China (English)

    Ganesan Ganesan Ram; Perumal Suresh; Phagal Varthi Vijayaraghavan

    2014-01-01

    Objective:To assess the accuracy of the clinically estimated blood loss (EBL) when compared with the actual blood loss (ABL) in replacement surgeries.Methods:This prospective study was done in Sri Ramachandra Medical Centre from April 2011 to April 2013.Altogether 140 patients undergoing total hip replacement or total knee replacement were included with the inclusion criteria being patients with haemoglobin higher than 100 g/ml and coagulation profile within normal limits.Exclusion criteria were intake of antiplatelet drug or anti-coagulant,bleeding disorders,thrombotic episode,and haematological disorders.There were 65 men and 75 women.In this study,the consultants were free to use any clinical method to estimate the blood loss,including counting the blood-soaked mops and gauze pieces (estimating the volume of blood carded in all the mops and gauzes),measuring blood lost to suction bottles and blood in and around the operative field.The ABL was calculated based on a modification of the Gross's formula using haematocrit values.Results:In 42 of the 140 cases,the EBL exceeded the ABL.These cases had a negative difference in blood loss (or DIFF-BL<0) and were included in the overestimation group,which accounted for 30% of the study population.Of the remaining 98 cases (70%),the ABL exceeded the EBL.Therefore they were put into the underestimation group who had a positive difference in blood loss (DIFF-BL>0).We found that when the average blood loss was small,the accuracy of estimation was high.But when the average blood loss exceeded 500 ml,the accuracy rate decreased significantly.This suggested that clinical estimation is inaccurate with the increase of blood loss.Conclusion:This study has shown that using clinical estimation alone to guide blood transfusion is inadequate.In this study,70% of patients had their blood loss underestimated,proving that surgeons often underestimate blood loss in replacement surgeries.

  1. Four Methods for Calculating Blood-loss after Total Knee Arthroplasty

    Institute of Scientific and Technical Information of China (English)

    Fu-Qiang Gao; Zi-Jian Li; Ke Zhang; Wei Sun; Hong Zhang

    2015-01-01

    Background:Currently,various calculation methods for evaluating blood-loss in patients with total knee arthroplasty (TKA) are applied in clinical practice.However,different methods may yield different results.The purpose of this study was to determine the most reliable method for calculating blood-loss after primary TKA.Methods:We compared blood-loss in 245 patients who underwent primary unilateral TKA from February 2010 to August 2011.We calculated blood-loss using four methods:Gross equation,hemoglobin (Hb) balance,the Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) formula,and Hb-dilution.We determined Pearson's correlation coefficients for the four methods.Results:There were large differences in the calculated blood-loss obtained by the four methods.In descending order of combined correlation coefficient based on calculated blood-loss,the methods were Hb-balance,OSTHEO formula,Hb-dilution,and Gross equation.Conclusions:The Hb-balance method may be the most reliable method of estimating blood-loss after TKA.

  2. Decadal changes in turbid-water coral communities at Pandora Reef: loss of resilience or too soon to tell?

    Science.gov (United States)

    Done, Terry; Turak, Emre; Wakeford, Mary; Devantier, Lyndon; McDonald, Abbi; Fisk, David

    2007-12-01

    Coral communities were monitored at Pandora Reef, nearshore Great Barrier Reef from 1981 to 2005 using photography and videography. In the 1980s, regional elevation of land-based nutrients in coastal waters (ca. 2-6 times pre-European levels of early 1800s) did not prevent overall recovery of coral cover and diversity following a sequence of environmental disturbances in the 1970s. However, prospects for a repeat of such resilience following catastrophic mortality from high-temperature bleaching in 1998 and a cyclone in 2000 are not clear. Different coral communities around the reef varied greatly in relation to impacts and recovery. Fore-reef communities dominated by acroporids (fast growing branching and tabular Acropora and foliose Montipora) recovered strongly in the 1980s following apparently severe impacts by cyclone, flood and heat wave disturbances in the 1970s, attaining 60-90% cover by stabilizing rubble and outgrowing macro-algae in reef, by contrast, poritid-dominated communities (massive and finger Porites and columnar Goniopora and Alveopora) had more stable trajectories and smaller impact from recent disturbances: recovery was well underway in 2005. The contrasting trajectories of different parts of the reef reflect differential survival of more persistent versus more ephemeral taxa, notably poritids and acroporids, respectively, both major contributors to framework and cover on reefs globally. A repeat of earlier resilience appears possible in the shallow fore-reef, but unlikely in the deeper fore-reef, which had few viable fragments or recruits in 2005. The main limits on recovery may be (1) reduced supply of coral larvae due to widespread regional losses of coral brood stock and (2) the reduced intervals between disturbances associated with global climate change. The presence of a high abundance of Acroporidae is a major pre-disposing risk factor for climate change impacts.

  3. A systematic review of the relationship between blood loss and clinical signs.

    Directory of Open Access Journals (Sweden)

    Rodolfo Carvalho Pacagnella

    Full Text Available INTRODUCTION: This systematic review examines the relationship between blood loss and clinical signs and explores its use to trigger clinical interventions in the management of obstetric haemorrhage. METHODS: A systematic review of the literature was carried out using a comprehensive search strategy to identify studies presenting data on the relationship of clinical signs & symptoms and blood loss. Methodological quality was assessed using the STROBE checklist and the general guidelines of MOOSE. RESULTS: 30 studies were included and five were performed in women with pregnancy-related haemorrhage (other studies were carried in non-obstetric populations. Heart rate (HR, systolic blood pressure (SBP and shock index were the parameters most frequently studied. An association between blood loss and HR changes was observed in 22 out of 24 studies, and between blood loss and SBP was observed in 17 out of 23 studies. An association was found in all papers reporting on the relationship of shock index and blood loss. Seven studies have used Receiver Operating Characteristic Curves to determine the accuracy of clinical signs in predicting blood loss. In those studies the AUC ranged from 0.56 to 0.74 for HR, from 0.56 to 0.79 for SBP and from 0.77 to 0.84 for shock index. In some studies, HR, SBP and shock index were associated with increased mortality. CONCLUSION: We found a substantial variability in the relationship between blood loss and clinical signs, making it difficult to establish specific cut-off points for clinical signs that could be used as triggers for clinical interventions. However, the shock index can be an accurate indicator of compensatory changes in the cardiovascular system due to blood loss. Considering that most of the evidence included in this systematic review is derived from studies in non-obstetric populations, further research on the use of the shock index in obstetric populations is needed.

  4. Individual-Specific, Beat-to-beat Trending of Significant Human Blood Loss: The Compensatory Reserve.

    Science.gov (United States)

    Convertino, Victor A; Howard, Jeffrey T; Hinojosa-Laborde, Carmen; Cardin, Sylvain; Batchelder, Paul; Mulligan, Jane; Grudic, Gregory Z; Moulton, Steven L; MacLeod, David B

    2015-08-01

    Current monitoring technologies are unable to detect early, compensatory changes that are associated with significant blood loss. We previously introduced a novel algorithm to calculate the Compensatory Reserve Index (CRI) based on the analysis of arterial waveform features obtained from photoplethysmogram recordings. In the present study, we hypothesized that the CRI would provide greater sensitivity and specificity to detect blood loss compared with traditional vital signs and other hemodynamic measures. Continuous noninvasive vital sign waveform data, including CRI, photoplethysmogram, heart rate, blood pressures, SpO2, cardiac output, and stroke volume, were analyzed from 20 subjects before, during, and after an average controlled voluntary hemorrhage of ∼1.2 L of blood. Compensatory Reserve Index decreased by 33% in a linear fashion across progressive blood volume loss, with no clinically significant alterations in vital signs. The receiver operating characteristic area under the curve for the CRI was 0.90, with a sensitivity of 0.80 and specificity of 0.76. In comparison, blood pressures, heart rate, SpO2, cardiac output, and stroke volume had significantly lower receiver operating characteristic area under the curve values and specificities for detecting the same volume of blood loss. Consistent with our hypothesis, CRI detected blood loss and restoration with significantly greater specificity than did other traditional physiologic measures. Single measurement of CRI may enable more accurate triage, whereas CRI monitoring may allow for earlier detection of casualty deterioration. PMID:25565640

  5. Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss

    Directory of Open Access Journals (Sweden)

    Johan S.J. Manshanden

    2015-09-01

    Conclusions: CPPF after cardiac surgery was found to be safe and feasible in this experimental setting. The clinically relevant effect on blood loss needs to be confirmed in a randomized clinical trial.

  6. Efficacy of prophylactic tranexamic acid in reducing blood loss during and after caesarean section

    Directory of Open Access Journals (Sweden)

    Bhavana G.

    2016-06-01

    Conclusions: Injection tranexamic acid is the, antifibrinolytic agent that can be used for prophylactic administration before caesarean section for decreasing blood loss during surgery. [Int J Reprod Contracept Obstet Gynecol 2016; 5(6.000: 2011-2016

  7. Efficacy of tranexamic acid in reducing blood loss during lower segment caesarean section

    Directory of Open Access Journals (Sweden)

    Vijayalaxmi Raghavendra Gobbur

    2014-04-01

    Results: Tranexamic acid significantly reduced the quantity of blood loss during LSCS 289.4 +/- 71.4 ml in the study group versus 328 +/- 58.9 ml in the control group (P = 0.004. It also significantly reduced the quantity of blood loss from placental delivery to 2 hours post-partum: 360.9 +/- 110.3 ml in the study group, versus 443 +/- 88.55 ml in the control group. (P = 0.0008. No complications or side effects were reported in either group. Conclusions: Tranexamic acid significantly reduces the blood loss during and after the caesarean section. Side effects like nausea, vomiting, diarrhoea and thrombosis are rare. Tranexamic acid can be used effectively in women undergoing LSCS to decrease the blood loss. [Int J Reprod Contracept Obstet Gynecol 2014; 3(2.000: 414-417

  8. Plummer-Vinson syndrome associated with chronic blood loss anemia and large diaphragmatic hernia.

    Science.gov (United States)

    Maleki, Dordaneh; Cameron, Alan J

    2002-01-01

    The coexistence of large diaphragmatic hernia and Plummer-Vinson syndrome in two patients is described. It is proposed that the hernias caused chronic blood loss anemia, and that iron deficiency then resulted in postcricoid web formation.

  9. Comparision of blood loss between computer assisted and conventional total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    Paras Kumar Mohanlal

    2013-01-01

    Conclusion: These results suggest that there is no significant difference in blood loss in CAS TKA and conventional TKA. This study also highlights the heterogeneity of methods used in studies related to CAS TKA. We believe that there is a need for a large multicenter prospective randomized controlled trial to be performed before a consensus can be reached on the influence of CAS techniques on blood loss during primary TKA.

  10. Hidden blood loss and its influential factors after total hip arthroplasty

    OpenAIRE

    Miao, Kaisong; Ni, Su; Zhou, Xianju; Xu, Nanwei; Sun, Rongbin; Zhuang, Chao; Wang, Yuji

    2015-01-01

    Background Total hip arthroplasty (THA) is a vital therapy for various hip joint diseases. However, patients have lower hemoglobin level post-operatively, remarkably inconsistent with the measured blood loss. The inconsistence is majorly attributed to hidden blood loss (HBL). In this study, we investigated the HBL and its influential factors among patients after THA. Methods From January 2008 to June 2014, 322 patients (99 males and 223 females) undergoing THA were enrolled in this study. All...

  11. Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients

    Directory of Open Access Journals (Sweden)

    Ramya Vel

    2015-01-01

    Full Text Available Background: Blood loss is often a major complication in neurosurgery that requires transfusion of multiple units of blood. The purpose of this study was to assess the effect of tranexamic acid (TXA on intraoperative blood loss and the need for blood transfusion in patients undergoing craniotomy for tumor excision. Materials and Methods: A total of 100 patients aged 18-60 years, with American Society of Anesthesiologists physical Status 1 and 2 scheduled to undergo elective craniotomy for tumor excision were enrolled. Patients received 10 mg/kg bolus about 20 min before skin incision followed by 1 mg/kg/h infusion of either TXA or saline. Hemodynamic variables, intravenous fluid transfused, amount of blood loss and blood given were measured every 2 h. Laboratory parameters such as serum electrolytes and fibrinogen values were measured every 3 h. On the 5 th postoperative day hemoglobin (POD Hb5, Hb estimation was done and the estimated blood loss (EBL calculated. Patients were also monitored for any complications. Results: The Mean heart rate in TXA group was significantly lower compared with the saline group. Mean arterial pressure and fibrinogen levels were higher in TXA group. The mean total blood loss in the TXA group was less than in the saline group. Blood transfusion requirements were comparable in two groups. The EBL and POD5 Hb were comparable in two groups. Conclusion: Even though, there is a significant reduction in the total amount of blood loss in TXA group. However, there was no reduction in intraoperative transfusion requirement.

  12. Doppler Assessment of Uterine Blood Flow in Recurrent Pregnancy Loss

    Directory of Open Access Journals (Sweden)

    Maryam Barzin

    2011-05-01

    Full Text Available Recurrent spontaneous abortion affects 2%-5% of"ncouples. Uterine perfusion is considered as one of the"nfactors that influences the success of implantation."nDuring the normal menstrual cycle, the impedance"nto uterine artery blood flow diminishes progressively"nduring the luteal phase, reaching the lowest values"nin the period coinciding with the implantation time."nImpedance of uterine arteries is a good indicator of"nthe possibility of a subsequent pregnancy. High blood"nflow resistance is associated with a reduced conception"nrate and women with lower pulsatility index values"nhave the highest possibility of becoming pregnant. An"nimpaired uterine perfusion could play a major role in"nthe pathogenesis of recurrent spontaneous abortion. In"nthis study, we examined sixty women with recurrent"nspontaneous abortion and a control group including"nthirty normal women with at least one previous"nuncomplicated pregnancy and without history of any"nabortion. Transvaginal sonography associated with"nDoppler flow measurement was performed during"nthe midluteal phase of a cycle in all women. The"nmeasurement of the ascending branch of both right"nand left uterine arteries was taken lateral to the cervix"nat the level of the internal os. The pulsatility and"nresistance index of both uterine arteries were calculated"nand compared in both groups. In this presentation we"nreport our finding in two groups. We also explain the"nexact method of study and present some interesting"ncases

  13. Clinical effects of applying a tourniquet in total knee arthroplasty on blood loss

    Institute of Scientific and Technical Information of China (English)

    ZHANG Fu-jiang; XIAO Yu; LIU Ya-bin; TIAN Xu; GAO Zhi-guo

    2010-01-01

    Background Tourniquets used during total knee arthroplasty may lead to many complications. The aim of this study was to determine perioperative blood loss and its clinical relevance in total knee replacement surgery after applying a tourniquet.Methods From June 2009 to October 2009, 60 consecutive patients who underwent routine total knee arthroplasty were randomly divided into two groups and were treated with or without a tourniquet (30 patients/group). There were no significant differences in patient baseline characteristics between the two groups. We compared the two groups of patients in terms of intra- and postoperative bleeding, invisible or visible bleeding, and total blood loss.Results None of the patients showed poor wound healing, lower extremity deep venous thrombosis or other complications. The amount of blood loss during surgery was lower in the tourniquet group than in the control group (P<0.01). However, postoperative visible bleeding (P <0.05) and occult bleeding (P <0.05) were significantly greater in the toumiquet group than in the control group. There was no significant difference in the total amount of blood loss between the two groups (P >0.05).Conclusions Tourniquet can reduce bleeding during total knee replacement surgery, but is associated with greater visible and invisible blood loss.

  14. Effect of Desmopressin on Platelet Aggregation and Blood Loss in Patients Undergoing Valvular Heart Surgery

    Institute of Scientific and Technical Information of China (English)

    Lei Jin; Hong-Wen Ji

    2015-01-01

    Background:Blood loss after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass.Desmopressin or 1-deamino-8-D-arginine vasopressin (DDAVP) is a synthetic analog of vasopressin.DDAVP can increase the level of von Willebrand factor and coagulation factor Ⅷ,thus it may enhance PLT function and improve coagulation.In this study,we assessed the effects of DDAVP on PLT aggregation and blood loss in patients undergoing cardiac surgery.Methods:A total of 102 patients undergoing valvular heart surgery (from October 2010 to June 2011) were divided into DDAVP group (n =52) and control group (n =50).A dose of DDAVP (0.3 μtg/kg) was administered to the patients intravenously when they were being re-warmed.At the same time,an equal volume of saline was given to the patients in the control group.PLT aggregation rate was measured with the AggRAM four-way PLT aggregation measurement instrument.The blood loss and transfusion,hemoglobin levels,PLT counts,and urine outputs at different time were recorded and compared.Results:The postoperative blood loss in the first 6 h was significantly reduced in DDAVP group (202 ± 119 ml vs.258 ± 143 ml,P =0.023).The incidence of fresh frozen plasma (FFP) transfusion was decreased postoperatively in DDAVP group (3.8% vs.12%,P =0.015).There was no significant difference in the PLT aggregation,urine volumes,red blood cell transfusions and blood loss after 24 h between two groups.Conclusions:A single dose of DDAVP can reduce the first 6 h blood loss and FFP transfusion postoperatively in patients undergoing valvular heart surgery,but has no effect on PLT aggregation.

  15. Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss

    Science.gov (United States)

    Manshanden, Johan S.J.; Gielen, Chantal L.I.; de Borgie, Corianne A.J.M.; Klautz, Robert J.M.; de Mol, Bas A.J.M.; Koolbergen, David R.

    2015-01-01

    Background Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative pericardial flushing (CPPF) with an irrigation solution may reduce blood loss by preventing the accumulation of clots. In this pilot study, the safety and feasibility of CPPF were evaluated and the effect on blood loss and other related complications was investigated. Methods Between November 2011 and April 2012 twenty-one adult patients undergoing surgery for congenital heart disease (CHD) received CPPF from sternal closure up to 12 h postoperative. With an inflow Redivac drain that was inserted through one of the chest tube incision holes, an irrigation solution (NaCl 0.9% at 38 °C) was delivered to the pericardial cavity using a volume controlled flushing system. Safety aspects, feasibility issues and complications were registered. The mean actual blood loss in the CPPF group was compared to the mean of a retrospective group (n = 126). Results CPPF was successfully completed in 20 (95.2%) patients, and no method related complications were observed. Feasibility was good in this experimental setting. Patients receiving CPPF showed a 30% (P = 0.038) decrease in mean actual blood loss 12 h postoperatively. Conclusions CPPF after cardiac surgery was found to be safe and feasible in this experimental setting. The clinically relevant effect on blood loss needs to be confirmed in a randomized clinical trial. PMID:26501121

  16. The responses of white blood cells to weight loss among young male judoists

    Directory of Open Access Journals (Sweden)

    Ardalan Shariat

    2013-09-01

    Full Text Available The purpose of this study was the assessment of white blood cells in response to acute and gradual weight loss among young male judoists. Material and Methods—Twenty four healthy young judoists aged 17.0±1.2 years (mean ± SD, with one year of experience in judo training, selected and they were randomly classified in two groups of acute weight loss and gradual weight loss. Blood sampling was conducted in three stages: 1 before weight loss, 2 18 hours after weight loss, and 3 after the last phase of physical exercise performance tests. Results— The average amount of white blood cells in the phase 2 for both groups didn’t increase meaningfully (Acute: P=0. 53, Gradual: P=0.48 but the increase in the phase 3 for both groups was significant (P<0.01. Conclusion— This study concludes that acute weight loss can result in changing the level of white blood cells which are determined in immunity system and related disease.

  17. Donation frequency, iron loss, and risk of cancer among blood donors

    DEFF Research Database (Denmark)

    Edgren, Gustaf; Reilly, Marie; Hjalgrim, Henrik;

    2008-01-01

    for cancers of the liver, lung, colon, stomach, and esophagus, which are thought to be promoted by iron overload (combined odds ratio [OR] = 0.70, 95% confidence interval [CI] = 0.58 to 0.84), but only among men and only with a latency of 3-7 years. The risk of non-Hodgkin lymphoma was higher among frequent......BACKGROUND: Long-term deleterious effects of repeated blood donations may be masked by the donors' healthy lifestyle. To investigate possible effects of blood donation and iron loss through blood donation on cancer incidence while minimizing "healthy donor effects," we made dose...... = 107140) were individually matched on sex, age, and county of residence. Using conditional logistic regression, we estimated relative risks of cancer according to number of blood donations made or estimated iron loss 3-12 years before a case patient was diagnosed with cancer. All statistical tests were...

  18. Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension

    OpenAIRE

    Farha Samar; Laskowski Daniel; George Deepa; Park Margaret M; Tang WH Wilson; Dweik Raed A; Erzurum Serpil C

    2013-01-01

    Abstract Background Reduced gas transfer in patients with pulmonary arterial hypertension (PAH) is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary blood volume available for gas exchange. Methods We tested this hypothesis by determination of lung diffusing capacity (DL) and its components, the alveolar capillary membrane diffusing capacity (Dm) and lung capillary blood volume (Vc) in 28 individuals with PAH in c...

  19. The effect of aspirin on blood loss and transfusion requirements in patients with femoral neck fractures.

    LENUS (Irish Health Repository)

    Manning, Brian J

    2012-02-03

    Although it is widely accepted that aspirin will increase the risk of intra- and post-operative bleeding, clinical studies have not consistently supported this assumption. We aimed to assess the effect of pre-operative aspirin on blood loss and transfusion requirements in patients undergoing emergency fixation of femoral neck fractures. A prospective case-control study was undertaken in patients presenting with femoral neck fractures. Parameters recorded included intra-operative blood loss, post-operative blood loss, transfusion requirements and peri-operative reduction in haemoglobin concentration. Of 89 patients presenting with femoral neck fractures 32 were on long-term aspirin therapy. Pre-operative aspirin ingestion did not significantly affect peri-operative blood loss, or change in haemoglobin concentration or haematocrit. However those patients taking aspirin pre-operatively had a significantly lower haemoglobin concentration and haematocrit and were more likely to be anaemic at presentation than those who were not receiving aspirin. Patients taking aspirin were also more likely to receive blood transfusion post-operatively.

  20. Radiochromium (chromium-51) evaluation of gastrointestinal blood loss associated with placebo, aspirin, and nabumetone

    Energy Technology Data Exchange (ETDEWEB)

    Lussier, A.; LeBel, E.

    1987-10-30

    Gastrointestinal blood loss is one of the most serious clinical events induced by drugs. To date, almost no nonsteroidal anti-inflammatory drug has been shown to be devoid of that side effect in a strictly controlled study. The objective of this study was to assess quantitatively, by use of radioactive chromium (chromium-51)-labeled red blood cells, gastrointestinal blood loss associated with nabumetone (1000 mg daily), aspirin (3.6 g daily), and placebo. A total of 37 normal subjects, divided among the three treatment groups and a fourth group that received no treatment, were assessed clinically and quantitatively for gastrointestinal blood loss over a period of 28 days of active treatment. The results with chromium-51, analyzed on a logarithmic scale, revealed no statistically significant differences between the nabumetone, placebo, and control groups. Gastrointestinal blood loss in the aspirin group, however, was elevated when compared with all other groups at a high level of statistical significance (p less than 0.001). It is concluded that, under conditions in which aspirin causes substantial gastrointestinal microbleeding, nabumetone is not significantly different from placebo.

  1. Reducing intraoperative lower segment blood loss in placenta previa with Ashok Anand stitch

    Directory of Open Access Journals (Sweden)

    Ashok R. Anand

    2013-04-01

    Full Text Available Background: To avoid the need for blood transfusions and reducing complications in cases of placenta previa during cesarean section delivery by a new simple innovative technique developed by Dr ASHOK ANAND known as Ashok Anand’s stitch. Methods: This stitch is based on the reasoning that taking the stitch bilaterally occludes the collaterals supplying the lower segment. As these are end arteries, their occlusion causes hemostasis in the lower segment. Sample size: 20 cases in each study group. Blood loss was estimated by standardized visual method (fixed container and mop. Results: By applying this technique in 20 cases, there was significant reduction in the blood loss compared to the control group, thereby reducing the need for blood transfusion (p value <0.05. Conclusions: Ashok Anand’s stitch is a simple and effective technique in controlling lower segment bleeding in cases of placenta previa during cesarean section thus avoiding the need for blood transfusions for operative blood loss and obstetric hysterectomy. The technique is easy to apply, less invasive and does not require any special instruments. It can be life-saving. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000: 135-140

  2. The beneficial effect of Batroxobin on blood loss reduction in spinal fusion surgery

    DEFF Research Database (Denmark)

    Hu, Hui-Min; Chen, Li; Frary, Charles Edward;

    2015-01-01

    Objective Our objective was to evaluate the efficacy and safety of Batroxobin on blood loss during spinal operations. Methods After obtaining approval from the ethics committee at the hospital along with informed written consent, we performed a double-blind, randomized, placebo-controlled study w...

  3. Significant reduction in blood loss in patients undergoing minimal extracorporeal circulation

    NARCIS (Netherlands)

    Gerritsen, W. B.; van Boven, W. J.; Smelt, M.; Morshuis, W. J.; van Dongen, H. P.; Haas, F. J.; Aarts, L. P.

    2006-01-01

    Several recent studies have shown differences in blood loss and allogeneic transfusion requirements between on-pump and off-pump coronary artery bypass grafting (CABG). Recently a new concept, the mini-extracorporeal circulation, was introduced to minimize the side effects of extracorporeal circulat

  4. Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty

    DEFF Research Database (Denmark)

    Nielsen, Christian Skovgaard; Jans, Øivind; Ørsnes, Thue;

    2016-01-01

    BACKGROUND: In total knee arthroplasty, both intravenous (IV) and intra-articular (IA) administration of tranexamic acid (TXA) have been shown to reduce blood loss in several randomized controlled trials, although routine use of systemic TXA is considerably more common. However, to our knowledge...

  5. Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs.

    Directory of Open Access Journals (Sweden)

    Alex Loukas

    2005-10-01

    Full Text Available BACKGROUND: Hookworms infect 730 million people in developing countries where they are a leading cause of intestinal blood loss and iron-deficiency anemia. At the site of attachment to the host, adult hookworms ingest blood and lyse the erythrocytes to release hemoglobin. The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1. METHODS AND FINDINGS: We show that vaccination of dogs with recombinant Ac-APR-1 induced antibody and cellular responses and resulted in significantly reduced hookworm burdens (p = 0.056 and fecal egg counts (p = 0.018 in vaccinated dogs compared to control dogs after challenge with infective larvae of A. caninum. Most importantly, vaccinated dogs were protected against blood loss (p = 0.049 and most did not develop anemia, the major pathologic sequela of hookworm disease. IgG from vaccinated animals decreased the catalytic activity of the recombinant enzyme in vitro and the antibody bound in situ to the intestines of worms recovered from vaccinated dogs, implying that the vaccine interferes with the parasite's ability to digest blood. CONCLUSION: To the best of our knowledge, this is the first report of a recombinant vaccine from a hematophagous parasite that significantly reduces both parasite load and blood loss, and it supports the development of APR-1 as a human hookworm vaccine.

  6. Hydroxyethyl Starch Reduces Coagulation Competence and Increases Blood Loss During Major Surgery

    DEFF Research Database (Denmark)

    Rasmussen, Kirsten C; Johansson, Pär I; Højskov, Michael;

    2014-01-01

    OBJECTIVE: This study evaluated whether administration of hydroxyethyl starch (HES) 130/0.4 affects coagulation competence and influences the perioperative blood loss. BACKGROUND: Artificial colloids substitute blood volume during surgery; with the administration of HES 130/0.4 (Voluven, Fresenius...... Kabi, Uppsala, Sweden) only a minor effect on coagulation competence is expected. METHODS: Eighty patients were scanned for enrollment in the study, and 40 patients fulfilled the inclusion criteria. Two patients withdrew their consent to participate in the study, and 5 patients were excluded. Thus, 16...... patients were randomized to receive lactated Ringer's solution and 17 to receive HES 130/0.4. RESULTS: Among the patients receiving HES 130/0.4, thrombelastography indicated reduced clot strength (P < 0.001) and blinded evaluation of the perioperative blood loss was 2.2 (range 0.5 to 5.0) versus 1.4 (range...

  7. High fibrinogen in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss.

    Directory of Open Access Journals (Sweden)

    Sho Kanzaki

    Full Text Available OBJECTIVES: We used hearing tests and peripheral blood sample analyses to characterize the pathology of idiopathic sudden sensorineural hearing loss (ISSNHL and to identify possible prognostic factors for predicting recovery of hearing loss. STUDY DESIGN: A retrospective, multicenter trial was conducted. METHODS: Two hundred three patients examined within 7 days after the onset of ISSNHL received prednisone with lipo-prostaglandin E1. Pure-tone auditory tests were performed before and after treatment with these drugs. Blood tests were performed on blood samples collected during the patients' initial visit to our clinic. RESULTS: In all patients, elevated white blood cell (WBC counts, fasting blood sugar levels, HgbA1c, and erythrocyte sedimentation rate (ESR significantly correlated with high hearing threshold measurements obtained on the initial visit. High fibrinogen levels, WBC counts, ESR, and low concentrations of fibrinogen degradation products (FDP were associated with lower hearing recovery rates. Additionally, different audiogram shapes correlated with different blood test factors, indicating that different pathologies were involved. CONCLUSIONS: High fibrinogen levels measured within seven days after ISSNHL onset correlated with poorer hearing recovery. This may be a consequence of ischemia or infections in the inner ear. The high WBC counts also observed may therefore reflect an immune response to inner ear damage induced by ischemic changes or infections. Our data indicate that therapeutic strategies should be selected based on the timing of initial treatment relative to ISSNHL onset.

  8. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients

    DEFF Research Database (Denmark)

    Husted, Henrik; Blønd, Lars; Sonne-Holm, Stig;

    2003-01-01

    INTRODUCTION: We performed a prospective, randomized, double-blind study on 40 patients scheduled for primary total hip arthroplasty due to arthrosis or osteonecrosis to determine the effect of tranexamic acid on per- and postoperative blood losses and on the number of blood transfusions needed....... PATIENTS AND METHODS: 40 patients were randomized to tranexamic acid (10 mg/kg given as a bolus intravenous injection, followed by a continuous infusion of 1 mg/kg/hour for 10 hours) or placebo (20 mL saline given intravenously) 15 minutes before the incision. We recorded the peroperative and postoperative...... blood losses at removal of the drain 24 hours after the operation and the number of blood transfusions. RESULTS: Patients receiving tranexamic acid had a mean peroperative blood loss of 480 mL versus 622 mL in patients receiving placebo (p = 0.3), a postoperative blood loss of 334 mL versus 609 mL (p...

  9. Telling time

    Directory of Open Access Journals (Sweden)

    Populizio Ivan

    2002-06-01

    the two opposite options of inquiring and telling about the time. The first task has traditionally been dealt with by science and philosophy, the latter by art, in particular through the narrative imagination and the opportunity to create a story. To reach “objective” and verifiable knowledge, science and philosophy had to pay the price of denying,though not completely, time as experienced by people. Art, on the other hand, has been able to put into practice the opportunities offered by the unreality of the time told, thus offering a provisional solution – poetic rather than theoretical – to the aporias raised by the clash between the time which is “made of moments” and the time that “passes”.

  10. Reduction of aspirin-induced fecal blood loss with low-dose misoprostol tablets in man

    International Nuclear Information System (INIS)

    Misoprostol (SC-29333), a synthetic prostaglandin E1 methyl ester analog, was given simultaneously with acetylsalicylic acid in a double-blind, placebo-controlled randomized prospective study of 32 healthy human male subjects. Fecal blood loss was measured for eight days using the 51Cr-labeled red blood cell technique. Aspirin (650 mg qid) and misoprostol (25 micrograms qid) or placebo were given during days 3, 4, and 5. There was a significant (P less than 0.05) increase in median blood loss (modified Friedman test) from 0.81 to 6.05 ml/day in the aspirin with placebo group (N = 16). Median blood loss was increased (from 0.75 to 3.75 ml/day) in the aspirin with misoprostol group (N = 16), but this was significantly less (Mann-Whitney U test, P less than 0.01) than the placebo group. Mean serum salicylate concentrations in the placebo and misoprostol groups were similar (7.8 and 6.8 micrograms/ml, respectively). There were no significant changes in laboratory values in any of the subjects studied, nor were any major side-effects encountered. This study demonstrates that oral misoprostol reduces aspirin-induced gastrointestinal bleeding even when administered simultaneously and at a dose level below its threshold for significant acid inhibition. This indicates a potential role for misoprostol in the prevention of gastric mucosal damage in selected patients

  11. Tranexamic acid for control of blood loss in bilateral total knee replacement in a single stage

    Directory of Open Access Journals (Sweden)

    Mandeep S Dhillon

    2011-01-01

    Full Text Available Background: Tranexamic acid (TEA reduces blood loss and red cell transfusions in patients undergoing unilateral total knee arthroplasty (TKA. However, there is not much literature regarding the use of TEA in patients undergoing bilateral TKA in a single stage and the protocols for administration of TEA in such patients are ill-defined. Materials and Methods: We carried out a case control study evaluating the effect of TEA on postoperative hemoglobin (Hb, total drain output, and number of blood units transfused in 52 patients undergoing bilateral TKA in a single stage, and compared it with 56 matched controls who did not receive TEA. Two doses of TEA were administered in doses of 10 mg / kg each (slow intravenous (IV infusion, with the first dose given just before tourniquet release of the first knee and the second dose three hours after the first one. Results: A statistically significant reduction in the total drain output and requirement of allogenic blood transfusion in cases who received TEA, as compared to the controls was observed. The postoperative Hb and Hb at the time of discharge were found to be lower in the control group, and this result was found to be statistically significant. Conclusion: TEA administered in patients undergoing single stage bilateral TKA helped reduce total blood loss and decreased allogenic blood transfusion requirements. This might be particularly relevant, where facilities such as autologous reinfusion might not be available.

  12. Use of tranexamic acid in primary total knee replacement: effects on perioperative blood loss

    Directory of Open Access Journals (Sweden)

    Daniel Volquind

    2016-06-01

    Full Text Available ABSTRACT BACKGROUND AND OBJECTIVES: The use of tranexamic acid in primary total knee replacement surgeries has been the subject of constant study. The strategies to reduce bleeding are aimed at reducing the need for blood transfusion due to the risks involved. In this study we evaluated the use of tranexamic acid in reducing bleeding, need for blood transfusion, and prevalence of postoperative deep vein thrombosis in primary total knee replacement. METHOD: 62 patients undergoing primary total knee replacement were enrolled in the study, from June 2012 to May 2013, and randomized to receive a single dose of 2.5 g of intravenous tranexamic acid (Group TA or saline (Group GP, 5 min before opening the pneumatic tourniquet, respectively. Hemoglobin, hematocrit, and blood loss were recorded 24 h after surgery. Deep vein thrombosis was investigated during patient's hospitalization and 15 and 30 days after surgery in review visits. RESULTS: There was no demographic difference between groups. Group TA had 13.89% decreased hematocrit (p = 0.925 compared to placebo. Group TA had a decrease of 12.28% (p = 0.898 in hemoglobin compared to Group GP. Group TA had a mean decrease of 187.35 mL in blood loss (25.32% compared to group GP (p = 0.027. The number of blood transfusions was higher in Group GP (p = 0.078. Thromboembolic events were not seen in this study. CONCLUSION: Tranexamic acid reduced postoperative bleeding without promoting thromboembolic events.

  13. Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers.

    Science.gov (United States)

    Tang, Yong-Mei; Wang, Dao-Gang; Li, Jun; Li, Xing-Hua; Wang, Qian; Liu, Nan; Liu, Wei-Tian; Li, Ying-Xue

    2016-06-10

    We aimed to examine the effect of micronutrient losses through sweat on blood pressure (BP) among heat-exposed steelworkers. A total of 224 heat-exposed male steelworkers from an ironworks facility were evaluated in July 2012. We measured the Wet Bulb Globe Temperature Index to evaluate the level of heat stress in the workplace. We collected sweat from the workers during an eight-hour work, and then we measured the micronutrients in the sweat. We also measured the BP of each worker. The results revealed that vitamin C, potassium, and calcium losses in sweat were positively correlated with systolic (SBP) and diastolic (DBP) blood pressure (all P900 mg, or >100 mg, respectively. Further, DBP increased when potassium or calcium losses in sweat were >600 mg or >130 mg, respectively. Therefore, vitamin C, potassium, and calcium losses in sweat may adversely effect BP. To help steelworkers maintain healthy BP, facilities with high temperatures should try to lower environmental temperatures to reduce vitamin C, potassium, and calcium losses in sweat. Additionally, heat-exposed steelworkers may need to increase their dietary intakes of vitamin C, potassium, and calcium. Further research is needed to confirm these findings and support these recommendations. PMID:27087421

  14. Longitudinal changes in blood pressure during weight loss and regain of weight in obese boys and girls

    DEFF Research Database (Denmark)

    Holm, Jens-Christian; Gamborg, Michael; Neland, Mette;

    2012-01-01

    To investigate blood pressure (BP) in relation to changes in body mass index (BMI) in obese children during weight loss and subsequent weight regain.......To investigate blood pressure (BP) in relation to changes in body mass index (BMI) in obese children during weight loss and subsequent weight regain....

  15. Influence of curve magnitude and other variables on operative time, blood loss and transfusion requirements in adolescent idiopathic scoliosis.

    LENUS (Irish Health Repository)

    Nugent, M

    2015-05-03

    Posterior spinal instrumentation and fusion for correction of adolescent idiopathic scoliosis (AIS) typically requires lengthy operating time and may be associated with significant blood loss and subsequent transfusion. This study aimed to identify factors predictive of duration of surgery, intraoperative blood loss and transfusion requirements in an Irish AIS cohort.

  16. The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies

    NARCIS (Netherlands)

    J. de Lange; E.M. Baas; R.B.G. Horsthuis; A. Booij

    2008-01-01

    Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized cli

  17. [Influence of some anesthesiologic methods on blood loss in procedures for voluntary termination of pregnancy].

    Science.gov (United States)

    Venuti, F S; Granese, D; Fattori, A

    1980-03-01

    120 patients in good health, aged 25-38, all in the first trimester of pregnancy, and requesting interruption of pregnancy, were divided into 4 groups and given different types of anesthesia; 1) general anesthesia with volatile anesthetics; 2) general anesthesia without volatile anesthetics; 3) dissociated anesthesia with Ketamin; and, 4) paracervical block with Mepivacain 1%. All interventions were done through curettage, and lasted 7-18 minutes; in all cases blood loss was carefully collected and measured. Minimum amount of bleeding was noted with paracervical block; maximum amount with volatile anesthetics such as ethrane. For every type of anesthesia blood loss increased with age of pregnancy. There were no postoperative complications. As confirmed by the published literature anesthesia by paracervical block is an easy, uncomplicated method, which requires little preparation time and which can be done at low cost.

  18. Blood Loss and Transfusion After Topical Tranexamic Acid Administration in Primary Total Knee Arthroplasty.

    Science.gov (United States)

    Wang, Hao; Shen, Bin; Zeng, Yi

    2015-11-01

    There has been much debate and controversy about the safety and efficacy of the topical use of tranexamic acid in primary total knee arthroplasty (TKA). The purpose of this study was to perform a meta-analysis to evaluate whether there is less blood loss and lower rates of transfusion after topical tranexamic acid administration in primary TKA. A systematic review of the electronic databases PubMed, CENTRAL, Web of Science, and Embase was undertaken. All randomized, controlled trials and prospective cohort studies evaluating the effectiveness of topical tranexamic acid during primary TKA were included. The focus of the analysis was on the outcomes of blood loss results, transfusion rate, and thromboembolic complications. Subgroup analysis was performed when possible. Of 387 studies identified, 16 comprising 1421 patients (1481 knees) were eligible for data extraction and meta-analysis. This study indicated that when compared with the control group, topical application of tranexamic acid significantly reduced total drain output (mean difference, -227.20; 95% confidence interval, -347.11 to -107.30; Pdeep venous thrombosis or pulmonary embolism due to tranexamic acid administration. Topical tranexamic acid was effective for reducing postoperative blood loss and transfusion requirements without increasing the prevalence of thromboembolic complications. PMID:26558665

  19. Benefits of commercial weight-loss programs on blood pressure and lipids: a systematic review.

    Science.gov (United States)

    Mehta, Ambereen K; Doshi, Ruchi S; Chaudhry, Zoobia W; Jacobs, David K; Vakil, Rachit M; Lee, Clare J; Bleich, Sara N; Clark, Jeanne M; Gudzune, Kimberly A

    2016-09-01

    Our objective was to compare the effect of commercial weight-loss programs on blood pressure and lipids to control/education or counseling among individuals with overweight/obesity. We conducted a systematic review by searching MEDLINE and Cochrane Database of Systematic Reviews from inception to November 2014 and references identified by the programs. We included randomized, controlled trials ≥12weeks in duration. Two reviewers extracted information on study design, interventions, and mean change in systolic blood pressure (SBP), diastolic blood pressure (DBP), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides, and total cholesterol and assessed risk of bias. We included 27 trials. Participants' blood pressure and lipids were normal at baseline in most trials. At 12months, Weight Watchers showed little change in blood pressure or lipid outcomes as compared to control/education (2 trials). At 12months, Atkins' participants had higher HDL-c and lower triglycerides than counseling (4 trials). Other programs had inconsistent effects or lacked long-term studies. Risk of bias was high for most trials of all programs. In conclusion, limited data exist regarding most commercial weight-loss programs' long-term effects on blood pressure and lipids. Clinicians should be aware that Weight Watchers has limited data that demonstrate CVD risk factor benefits relative to control/education. Atkins may be a reasonable option for patients with dyslipidemia. Additional well-designed, long-term trials are needed to confirm these conclusions and evaluate other commercial programs. PMID:27373206

  20. EFFECT OF TRANEXAMIC ACID IN CONTROL OF PERIOPERATIVE BLOOD LOSS ASSOCIATE WITH TOTAL KNEE REPLACEMENT OUR EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Bhaskar

    2015-05-01

    Full Text Available BACKGROUND : Costs of allogenic blood transfusions and the associated risks mandate strategies to reduce blood loss in surgery. The objective of this study was to asse ss the efficacy of antifibrinolytic treatment in reducing perioperative blood loss during total knee replacement. MATERIALS AND METHOD S: A prospective study was carried out on 148patients undergoing total knee replacement. 88pts received tranexamic acid 10 mg kg −1 i.v. just before the cementation, 3hours post op and 6 hrs later.60 patients did not receive tranexamic acid. External perioperative blood loss was measured by post op amount of drain, and Hb levels and Hematocrit. The number of patients transfuse d and number of packed red cell (PRC units transfused was recorded and possible postoperative thrombo embolic complications were studied clinically. RESULTS : Amongst 78 pts who were given Cyclokapron, only 10(12.8% were given blood transfusions and the a verage transfusions were 3.9 units and Amongst 70 pts who were not given Cyclokapron, 20(28.5% were given blood transfusions and the average transfusions were 8.7 units. The average blood loss in the group of patients who were given cyclokapron was 1004ml while in the groups which were not given the average blood loss was 1507ml. Clinical assessment did not reveal any thromboembolic complications. CONCLUSIONS : Antifibrinolytic agents produce a significant decrease in blood loss in patients undergoing total knee replacement, reflected in a reduction in the number of blood transfusions required. Based on this study we can conclude that three doses of IV tranexamic acid of 10mg/kg, can be used in TKR procedures with proven effectiveness and efficiency to decre ase postoperative blood loss in patients undergoing TKR.

  1. The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery : A meta-analysis

    NARCIS (Netherlands)

    Schouten, Esther S.; van de Pol, Alma C.; Schouten, Anton N. J.; Turner, Nigel M.; Jansen, Nicolaas J. G.; Bollen, Casper W.

    2009-01-01

    Objective: Aprotinin reduces the blood loss and transfusion of blood products in children undergoing major surgery. Aprotinin has been associated with severe side effects in adults, and tranexamic acid and aminocaproic acid have been found to be safer alternatives in adults. This systematic review a

  2. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients

    DEFF Research Database (Denmark)

    Husted, Henrik; Blønd, Lars; Sonne-Holm, Stig;

    2003-01-01

    = 0.001), a total blood loss of 814 mL versus 1231 mL (p = 0.001) and a total need for 4 blood transfusions versus 25 (p = 0.04). No patient in either group had symptoms of deep venous thrombosis, pulmonary embolism or prolonged wound drainage. INTERPRETATION: Transemic acid is effective in reducing...

  3. Intravenous 1 gram tranexamic acid for prevention of blood loss and blood transfusion during caesarean section: a randomized case control study

    Directory of Open Access Journals (Sweden)

    Babita Ramani

    2014-04-01

    Full Text Available Background: Aim of current study was to determine the effect of tranexamic acid in reducing blood loss during and after C-section. Methods: All women undergoing LSCS were divided in two groups viz study and control group. All were requested for pre-op and post-op Hb%, PCV and TRBC. Intravenous tranexamic acid one gm was given to study group (not to control group 10 min prior to skin incision and blood loss in both groups was calculated by weighing prewieghed pads soaked in blood. Results: Post-op blood loss was significantly lower in study group (P = 0.020. Hb% changes in post-op period is significant in control group (P = 0.037. Conclusions: Tranexamic acid is safe and effective in preventing post-partum hemorrhage after caesarean section. [Int J Reprod Contracept Obstet Gynecol 2014; 3(2.000: 366-369

  4. Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes.

    Directory of Open Access Journals (Sweden)

    Joel M O'Bryan

    Full Text Available BACKGROUND: Type I interferons have pleiotropic effects on host cells, including inhibiting telomerase in lymphocytes and antiviral activity. We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocytes. METHODS/PRINCIPAL FINDINGS: Using a flow cytometry-based telomere length assay on peripheral blood mononuclear cell samples from the Hepatitis-C Antiviral Long-term Treatment against Cirrhosis (HALT-C study, we measured T cell telomere lengths at screening and at months 21 and 45 in 29 Hepatitis-C virus infected subjects. These subjects had failed to achieve a sustained virologic response following 24 weeks of pegylated-interferon-alpha plus ribavirin treatment and were subsequently randomized to either a no additional therapy group or a maintenance dose pegylated-IFNα group for an additional 3.5 years. Significant telomere loss in naïve T cells occurred in the first 21 months in the interferon-alpha group. Telomere losses were similar in both groups during the final two years. Expansion of CD8(+CD45RA(+CD57(+ memory T cells and an inverse correlation of alanine aminotransferase levels with naïve CD8(+ T cell telomere loss were observed in the control group but not in the interferon-alpha group. Telomere length at screening inversely correlated with Hepatitis-C viral load and body mass index. CONCLUSIONS/SIGNIFICANCE: Sustained interferon-alpha treatment increased telomere loss in naïve T cells, and inhibited the accumulation of T cell memory expansions. The durability of this effect and consequences for immune senescence need to be defined.

  5. What economic theory tells us about the impacts of reducing food losses and/or waste: implications for research, policy and practice

    OpenAIRE

    Rutten, M.M.

    2013-01-01

    Background - Whereas the prevalence of hunger and food insecurity is often cited as a motivation for reducing losses and waste in agriculture and food systems, the impacts of such reduction on food security and the wider economy have not yet been investigated. This paper gives insights into these effects, the factors of influence, and derives implications for applied research, policy and practice. Methods - We used economic theory to analyse the impacts of food loss reductions on the supply s...

  6. Relative blood loss and operative time can predict length of stay following orthognathic surgery.

    Science.gov (United States)

    Andersen, K; Thastum, M; Nørholt, S E; Blomlöf, J

    2016-10-01

    The aim of this study was to investigate the length of stay (LOS) following orthognathic surgery and thereby to establish a benchmark. The secondary aim was to identify predictors of postoperative LOS following orthognathic surgery. Patients were treated consecutively during the period 2010 to 2012. Inclusion criteria were (1) patient age ≥18 years, and (2) surgery involving a three-piece Le Fort I osteotomy, or a bilateral sagittal split osteotomy (BSSO), or bimaxillary surgery. A total of 335 patients were included. The following data were recorded: height, weight, body mass index (BMI), age, sex, operative time, intraoperative blood loss, and type of surgery. LOS was defined as the duration of time from date of surgery to date of discharge. The average LOS was 1.3 days following Le Fort I osteotomy, 1.3 days following BSSO, and 1.8 days following bimaxillary surgery. In the multivariate regression model (R(2)=0.11), predictors of a prolonged LOS were operative time (P<0.001) and relative blood loss (P=0.002). No significant effect of age, BMI, sex, or treatment on LOS was observed. The short duration of LOS found in this study supports the possibility of increasing outpatient pathways for selected patients.

  7. Tranexamic acid reduces blood loss and need of blood transfusion in total knee arthroplasty: A prospective, randomized, double-blind study in Indian population

    Directory of Open Access Journals (Sweden)

    Abhishek Shinde

    2015-01-01

    Full Text Available Introduction: For quite a few years, tranexamic acid (TEA has been used during total knee arthroplasty (TKA to reduce blood loss. However, no consensus exits regarding its timing and doses. Materials and Methods: We conducted a prospective, randomized double-blinded study of 56 patients in the Indian population undergoing TKA from 2011 to 2012. A dose of 10 mg/kg body weight of TEA (three doses was given in one group and normal saline was administered in the other. Results: The mean blood loss in the TEA unilateral group was 295 mL ± 218 mL and in the placebo group was 482 mL ± 186 mL (P < 0.005. In the bilateral TEA group, the mean blood loss was 596 mL ± 235 mL and in the placebo group was 1349 mL ± 41 mL (P < 0.005. Conclusion: The number of patients requiring blood transfusion reduced substantially. There was no increase in the risk of deep vein thrombosis (DVT and pulmonary embolism. TEA reduces intraoperative and postoperative blood loss and thus reduces the need of allogenic blood transfusion.

  8. DOES TRANEXAMIC ACID REDUCE BLOOD LOSS IN OFF-PUMP CORONARY ARTERY BYPASS?

    Directory of Open Access Journals (Sweden)

    A. Mehr-Aein

    2006-09-01

    Full Text Available Tranexamic acid is now used on a routine basis for on-pump coronary artery bypass grafting (CABG. We assessed the hemostatic effects of tranexamic acid to decrease bleeding tendency and transfusion requirements in patients undergoing off-pump coronary artery bypass surgery (OPCAB. A total of 66 patients were enrolled to elective OPCAB in a double-blind, prospective randomized study. Of these, 33 patients received tranexamic acid (15 mg/kg before the infusion of heparin and 15 mg/kg after protamin infusion, and 33 patients received only saline. Preoperative hematologic variables, postoperative bleeding and allogeneic transfusions were considered. D-dimer plasma levels were also evaluated to monitor the activation of fibrinolysis. Postoperative bleeding was significantly lower in the tranexamic acid group compared with the control group (320 ± 38 mL vs. 480 ± 75 mL at 12 hour, P < 0.001. The tranexamic acid group had significantly lesser need for allogeneic blood products (0.46 units/patients vs. 0.94 units/patients, P < 0.001. They had also lower post-operative D-dimer plasma levels. No postoperative thrombotic complications were observed in either group. The defective hemostasis occurs even in the OPCABG. Tranexamic acid effectively reduces postoperative blood loss and the need for allogeneic blood products after OPCAB is decreased.

  9. Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension

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    Farha Samar

    2013-01-01

    Full Text Available Abstract Background Reduced gas transfer in patients with pulmonary arterial hypertension (PAH is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary blood volume available for gas exchange. Methods We tested this hypothesis by determination of lung diffusing capacity (DL and its components, the alveolar capillary membrane diffusing capacity (Dm and lung capillary blood volume (Vc in 28 individuals with PAH in comparison to 41 healthy individuals, and in 19 PAH patients over time. Using single breath simultaneous measure of diffusion of carbon monoxide (DLCO and nitric oxide (DLNO, DL and Dm were respectively determined, and Vc calculated. Dm and Vc were evaluated over time in relation to standard clinical indicators of disease severity, including brain natriuretic peptide (BNP, 6-minute walk distance (6MWD and right ventricular systolic pressure (RVSP by echocardiography. Results Both DLCO and DLNO were reduced in PAH as compared to controls and the lower DL in PAH was due to loss of both Dm and Vc (all p CO of PAH patients did not change over time, DLNO decreased by 24 ml/min/mmHg/year (p = 0.01. Consequently, Dm decreased and Vc tended to increase over time, which led to deterioration of the Dm/Vc ratio, a measure of alveolar-capillary membrane functional efficiency without changes in clinical markers. Conclusions The findings indicate that lower than normal gas transfer in PAH is due to loss of both Dm and Vc, but that deterioration of Dm/Vc over time is related to worsening membrane diffusion.

  10. Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension

    Science.gov (United States)

    2013-01-01

    Background Reduced gas transfer in patients with pulmonary arterial hypertension (PAH) is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary blood volume available for gas exchange. Methods We tested this hypothesis by determination of lung diffusing capacity (DL) and its components, the alveolar capillary membrane diffusing capacity (Dm) and lung capillary blood volume (Vc) in 28 individuals with PAH in comparison to 41 healthy individuals, and in 19 PAH patients over time. Using single breath simultaneous measure of diffusion of carbon monoxide (DLCO) and nitric oxide (DLNO), DL and Dm were respectively determined, and Vc calculated. Dm and Vc were evaluated over time in relation to standard clinical indicators of disease severity, including brain natriuretic peptide (BNP), 6-minute walk distance (6MWD) and right ventricular systolic pressure (RVSP) by echocardiography. Results Both DLCO and DLNO were reduced in PAH as compared to controls and the lower DL in PAH was due to loss of both Dm and Vc (all p DLNO decreased by 24 ml/min/mmHg/year (p = 0.01). Consequently, Dm decreased and Vc tended to increase over time, which led to deterioration of the Dm/Vc ratio, a measure of alveolar-capillary membrane functional efficiency without changes in clinical markers. Conclusions The findings indicate that lower than normal gas transfer in PAH is due to loss of both Dm and Vc, but that deterioration of Dm/Vc over time is related to worsening membrane diffusion. PMID:23339456

  11. Whole body 59Fe-elimination rates and corresponding blood losses in patients with factitious anemia induced by self-blood letting

    International Nuclear Information System (INIS)

    Within a year two cases were identified and quantitated for blood losses by whole body counting of retained iron. Whereas the 2 patients did not lose much blood during their observation within the hospital their blood losses increased upon release from the hospital. Although they lost about 5 liter blood in 50 days faecal occult blood tests were always negative and the daily faecal and urinary 59Fe-excretion was within the normal range. Haemoglobin and erythrocyte levels were stable during the periods of clinical observation when the whole body 59Fe-elimination rates were only just above the normal range. These values dropped however to very low values during or following periods of extremely elevated whole body 59Fe-elimination rates immediately after release of the patients from the hospital. Blood losses of up to 145 ml/d (=50 mg Fe/d) can be compensated by oral ferrous iron therapy with 4 x 50 = 200 mg Fe2+ /d. The patients did however refuse to take oral or parenteral iron and insisted in one case on regular blood transfusions twice per week. Two more probable cases of factitious anemia were subsequently observed and partially investigated. (orig./MG)

  12. Effects of preoperative β-blocker on blood loss and blood transfusion during spinal surgeries with sodium nitroprusside-controlled hypotension

    Directory of Open Access Journals (Sweden)

    Yasser Mohamed Amr

    2012-01-01

    Full Text Available Background: The present study sought to determine whether premedication with oral β-blocker before hypotensive anesthesia with sodium nitroprusside could improve the quality of surgical field, decrease the blood loss, and decrease the need for homologous blood transfusion and duration of surgery. Methods: Eighty patients scheduled for spinal fixation surgery were included in a prospective, randomized, double-blinded study. Patients were classified into two groups: Group I received oral atenolol 50 mg twice one day before surgery; and Group II received placebo tablets identical in appearance to atenolol tablets for the same period and interval. All patients in both the groups received intraoperative sodium nitroprusside (SNP as a hypotensive agent. Hemodynamic variables, amount of sodium nitroprusside used, quality of surgical field, and the amount of homologous blood transfusion and blood loss were compared between groups. Results: Heart rate and amount of SNP used were significantly less (P<0.0001 in the atenolol group, but no significant difference was found in intraoperative mean arterial blood pressure (MABP between the two groups. The time of surgeries was significantly shorter in Group I than in Group II (185±15.21 vs 225±12.61 min, P<0.0001. The quality of surgical field was better in Group I than in Group II in all times of measurements, P<0.0001. The amount of blood loss and the amount of packed red blood cells transfused were significantly less in Group I than in Group II, P<0.0001. No clinically significant complications were observed in either group. Conclusion: Premedication with oral atenolol 50 mg twice/day for one day before hypotensive anesthesia with SNP during spinal surgeries seems to be clinically safe and effective to reduce heart rate, amount of SNP used, amount of blood loss, and amount of blood transfused with better quality of surgical field.

  13. Plasmalemma Vesicle-Associated Protein Has a Key Role in Blood-Retinal Barrier Loss.

    Science.gov (United States)

    Wisniewska-Kruk, Joanna; van der Wijk, Anne-Eva; van Veen, Henk A; Gorgels, Theo G M F; Vogels, Ilse M C; Versteeg, Danielle; Van Noorden, Cornelis J F; Schlingemann, Reinier O; Klaassen, Ingeborg

    2016-04-01

    Loss of blood-retinal barrier (BRB) properties induced by vascular endothelial growth factor (VEGF) and other factors is an important cause of diabetic macular edema. Previously, we found that the presence of plasmalemma vesicle-associated protein (PLVAP) in retinal capillaries associates with loss of BRB properties and correlates with increased vascular permeability in diabetic macular edema. In this study, we investigated whether absence of PLVAP protects the BRB from VEGF-induced permeability. We used lentiviral-delivered shRNA or siRNA to inhibit PLVAP expression. The barrier properties of in vitro BRB models were assessed by measuring transendothelial electrical resistance, permeability of differently sized tracers, and the presence of endothelial junction complexes. The effect of VEGF on caveolae formation was studied in human retinal explants. BRB loss in vivo was studied in the mouse oxygen-induced retinopathy model. The inhibition of PLVAP expression resulted in decreased VEGF-induced BRB permeability of fluorescent tracers, both in vivo and in vitro. PLVAP inhibition attenuated transendothelial electrical resistance reduction induced by VEGF in BRB models in vitro and significantly increased transendothelial electrical resistance of the nonbarrier human umbilical vein endothelial cells. Furthermore, PLVAP knockdown prevented VEGF-induced caveolae formation in retinal explants but did not rescue VEGF-induced alterations in endothelial junction complexes. In conclusion, PLVAP is an essential cofactor in VEGF-induced BRB permeability and may become an interesting novel target for diabetic macular edema therapy.

  14. Telling stories: keeping secrets.

    Science.gov (United States)

    Jensen, Joan M

    2009-01-01

    This article addresses the reticence of some farm women to share their experiences with historians and how that desire to keep secrets collides with the desire by scholars to tell the stories of these women. It argues that scholars must continue to struggle with the issue of which stories to tell publicly and which to keep private. The author discusses her own experience telling stories about rural women in the 1970s and the need to give voice to the heritage of rural women, especially of groups that have feared revealing their experiences. She offers examples of historians of rural women who have successfully worked with formerly silenced populations and urges historians to continue to tell stories about these lives, to reevaluate what has been already learned, to ask new questions, and to discuss which secrets need to be shared.

  15. A RETROSPECTIVE STUDY OF THE IMPACT OF MEAN ARTERIAL PRESSURE ON ESTIMATED BLOOD LOSS DURING ENDOSCOPIC SINUS SURGERY

    Directory of Open Access Journals (Sweden)

    George W Williams

    2014-10-01

    Full Text Available The current practice of lowering mean arterial pressure (MAP during endoscopic sinus surgery (ESS is common, but unproven with regard to peer reviewed literature. The controlled hypotension induced is aimed for improved surgical field and lower the blood loss. Lower mean arterial pressures especially for prolonged surgeries may result in end organ hypoperfusion. The authors reviewed all patients who underwent outpatient endoscopic sinus surgery for the diagnosis of chronic sinusitis from January 1, 2012 to December 31, 2012 at Memorial Hermann Hospital – Texas Medical Centre. We individually reviewed case sheets of every patient and documented blood loss as recorded on the anaesthesia record or in the surgical procedure note, among other variables. A total of 326 patients were included in this study. The median estimated blood loss (EBL was found to be 50 ml. The multivariate regression analysis between these three groups showed that EBL was higher in MAP 75 group. The average of EBL in MAP75 group and the average of EBL in MAP 65-70 group is 42% higher than that in MAP>75 group when other variables were fixed. Hence we found the trend toward higher blood loss with lower MAP. The authors conclude that lower MAP does not result in lower EBL in endoscopic sinus surgery. Furthermore, increases in BMI and crystalloid administered during an aesthetic management of these cases correlates with increased estimate blood loss.

  16. (Re)solving Mysteries of Convection and Mass Loss of AGB Stars: What New Models and Observations Tell Us About Long-Standing Problems

    CERN Document Server

    Höfner, Susanne

    2016-01-01

    The recent progress in high-spatial-resolution techniques, spanning wavelengths from the visual to the radio regime, is leading to new valuable insights into the complex dynamical atmospheres of Asymptotic Giant Branch (AGB) stars and their wind forming regions. Striking examples are images of asymmetries and inhomogeneities in the photospheric and dust-forming layers which vary on time-scales of months. These features are probably related to large-scale convective flows predicted by 3D star-in-a-box models. Furthermore, high-resolution observations make it possible to measure dust condensation distances, and they give information about the chemical composition and sizes of dust grains in the close vicinity of cool giants. These are essential constraints for building realistic models of wind acceleration and developing a predictive theory of mass loss for AGB stars, which is a crucial ingredient of stellar and galactic chemical evolution models.

  17. Which Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty?

    Science.gov (United States)

    Keyhani, Sohrab; Esmailiejah, Ali Akbar; Abbasian, Mohammad Reza; Safdari, Farshad

    2016-01-01

    Background: The most appropriate route of tranexamic acid administration is controversial. In the current study, we compared the efficacy of intravenous (IV) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. Methods: One hundred twenty 120 patients were scheduled to undergo primary total knee arthroplasty. Patients were randomly allocated to three equal groups: IV tranexamic acid (500 mg), topical tranexamic acid (3 g in 100 mL normal saline) and the control. In the topical group, half of the volume was used to irrigate the joint and the other half was injected intra-articularly. The volume of blood loss, hemoglobin (Hb) level at 24 hours postoperative, and rate of transfusion was compared between groups. Results: The blood loss and Hb level were significantly greater and lower in the control group, respectively (P=0.031). Also, the rate of transfusion was significantly greater in the control group (P=0.013). However, IV and topical groups did not differ significantly in terms of measured variables. No patient experienced a thromboembolic event in our study. Conclusion: Tranexamic acid is a useful antifibrinolytic drug to reduce postoperative blood loss, Hb drop, and rate of blood transfusion in patients undergoing total knee arthroplasty. The route of tranexamic acid administration did not affect the efficacy and safety. PMID:26894222

  18. Axonal loss and blood flow disturbances in the natural course of indirect traumatic optic neuropathy

    Institute of Scientific and Technical Information of China (English)

    SHI Wei; WANG Huai-zhou; SONG Wei-xian; YANG Wen-li; LI Wei-ye; WANG Ning-li

    2013-01-01

    Background Indirect traumatic optic neuropathy (TON) is an acute injury of the optic nerve associated with severe visual dysfunction,which may be a result of secondary mechanical injury and vascular disorder of the optic nerve due to trauma.We analyzed the natural course of axonal loss and blood flow disturbances in patients with indirect TON to find a possible therapeutic window.Methods A cohort of 54 patients with indirect TON recruited between October 2008 and October 2010 at Beijing Tongren Hospital was retrospectively analyzed.The patients were divided into no light perception group (NLP) and better than NLP (btNLP) group.Specifically,the thickness of the retinal nerve fiber layer (RNFL) measured by spectral domain optical coherence tomography (SD-OCT),and hemodynamic parameters of the ophthalmic artery (OA),central retinal artery (CRA) and posterior ciliary artery (PCA) were determined.Results Two weeks after injury,there was a statistically significant decrease in the thickness of RNFL in the btNLP group as compared with the fellow control eyes (P <0.05).In contrast,in the NLP group,RNFL thickness slightly increased for 2 weeks following injury,then overtly reduced after 4 weeks (P <0.05).Peak systolic velocity (PSV) of CRA was significantly decreased 4 weeks after injury (P <0.05) in both the NLP group and btNLP group (P <0.05).The thickness of RNFL in the NLP group was negatively correlated with PSV of CRA after 1 week of injury (P <0.05,r=-0.962).Conclusions SD-OCT is a useful supplement in detecting the axonal loss in TON.The dynamic change of the thickness of RNFL appears to correlate with the hemodynamic disturbances in the natural course of TON.The first 2 weeks following an injury is critical and should be considered as the therapeutic window for TON patients.

  19. Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration.

    Science.gov (United States)

    Gu, Xiaowu; Fliesler, Steven J; Zhao, You-Yang; Stallcup, William B; Cohen, Alex W; Elliott, Michael H

    2014-02-01

    Blood-retinal barrier (BRB) breakdown and related vascular changes are implicated in several ocular diseases. The molecules and mechanisms regulating BRB integrity and pathophysiology are not fully elucidated. Caveolin-1 (Cav-1) ablation results in loss of caveolae and microvascular pathologies, but the role of Cav-1 in the retina is largely unknown. We examined BRB integrity and vasculature in Cav-1 knockout mice and found a significant increase in BRB permeability, compared with wild-type controls, with branch veins being frequent sites of breakdown. Vascular hyperpermeability occurred without apparent alteration in junctional proteins. Such hyperpermeability was not rescued by inhibiting eNOS activity. Veins of Cav-1 knockout retinas exhibited additional pathological features, including i) eNOS-independent enlargement, ii) altered expression of mural cell markers (eg, down-regulation of NG2 and up-regulation of αSMA), and iii) dramatic alterations in mural cell phenotype near the optic nerve head. We observed a significant NO-dependent increase in retinal artery diameter in Cav-1 knockout mice, suggesting that Cav-1 plays a role in autoregulation of resistance vessels in the retina. These findings implicate Cav-1 in maintaining BRB integrity in retinal vasculature and suggest a previously undefined role in the retinal venous system and associated mural cells. Our results are relevant to clinically significant retinal disorders with vascular pathologies, including diabetic retinopathy, uveoretinitis, and primary open-angle glaucoma.

  20. Effects of Three Types of Long-acting Contraceptive Implants on Menstrual Blood Loss in 89 Women

    Institute of Scientific and Technical Information of China (English)

    韩丽晖; 范慧民; 龚泉; 谢争; 孟凡; 洪玉凤; 王文娟

    1999-01-01

    Objective: To study the effects of three types of contraceptive implants: the domestic No I , No I implants and Norplant on menstrual blood loss (MBL). Method: Eighty-nine healthy subjects were randomly allocated to three groups.Menstrual blood loss was measured before implanting and 3, 6, and 12 months after implantation. Results: MBL of the three groups prior to the use of implant were 43. 3±6. 9ml,48.9±4. 3 ml, and 43.7±5. 5ml respectively, and decreased significantly at all post-implantation periods. MBLs were 32. 8±13. 2ml, 24. 8±5. 5ml, and 19. 7±9.3ml at the 3rd month after implantation and 23. 9±5. 9 ml, 40. 8±10. 4 ml, 25. 9±6. 0 ml at the 12th month after implantation respectively, sigmficantly less than before implantation(P<0. 05~0. 01). A tendency was seen in increase of hemoglobin concentraition. Conclusion: Long-acting contraceptive implants decreased menstrual blood loss and elevates hemoglobin concentration. They are applicable to women as a contraceptive method without blood loss effects.

  1. Influence of sibutramine in addition to diet and exercise on the relationship between weight loss and blood glucose changes

    DEFF Research Database (Denmark)

    Kamil, S; Finer, N; James, W P T;

    2016-01-01

    on glycemic control. METHODS AND RESULTS: 8192 obese patients with diabetes were randomized to sibutramine or placebo plus diet and exercise after a preliminary 6 weeks in which all patients received sibutramine. Patients were classified into four groups of weight change. A total of 1582 patients had a weight......AIMS: Weight loss is expected to improve glycemic control in patients with diabetes or at high risk hereof. Sibutramine causes weight loss and is associated with an increased risk of myocardial infarction and stroke in high risk patients. We examined the impact of sibutramine induced weight loss...... loss induced by sibutramine, diet, and exercise attenuates falls in blood glucose levels and HbA1c compared with similar weight loss with placebo, diet and exercise....

  2. Effect of antifibrinolytic drugs on transfusion requirement and blood loss during orthotopic liver transplantation: Results from a single center

    Directory of Open Access Journals (Sweden)

    Devi A

    2008-01-01

    Full Text Available Background: During orthotopic liver transplantation (OLT, activation of the fibrinolytic system can contribute significantly to perioperative bleeding. Prophylactic administration of antifibrinolytic agents has been shown to reduce blood loss and the need for allogenic transfusion. Objective: To study the effect of antifibrinolytics on requirement of blood components, blood loss and operative time during OLT in patients with end stage liver disease, reporting to a single centre. Materials and Methods: Consecutive patients who underwent OLT at this centre during the period February 2003-October 2007 were the subjects of this study. Based on the individual anesthesiologist′s preference, patients were assigned to receive either two million units of aprotinin (AP as a bolus followed by 5,00,000 units/hour or 10 mg/kg tranexamic acid (TAas a bolus followed by 10 mg/kg every six to eight hours, administered from the induction till the end of the surgery. Transfusion policy was standardized in all patients. Intraoperative red cell salvage was done wherever possible. The effect of these two antifibrinolytic drugs on transfusion requirement was evaluated as a whole and in a sub group of patients from each treatment group and compared with a concurrent control group that did not receive antifibrinolytic drugs. Results: Fifty patients (40 M / 10 F, 44 adults, 6 pediatric patients underwent OLT in the study period. Fourteen patients were given AP, 25 patients were given TA and 11 patients did not receive any of the agents(control group. The median volume of total blood components transfused in antifibrinolytic group (n=39 was 4540 ml(0-19,200ml, blood loss 5 l(0.7-35l and operative time 9h (4.5-17h and that of control group(n=11 was 5700 ml(0-15,500ml, 10 l(0.6-25 l and 9h (6.4-15.8h respectively. The median volume of blood transfusions, blood loss and operative time was lesser in AP group(n=14 than that of TA group(n=25. Conclusion: There is definite

  3. Story Telling and Educational Understanding

    Science.gov (United States)

    Denny, Terry

    2011-01-01

    In this paper, the author first places story telling in context within the broad range of effort associated with case study methods. Then, the author discusses aspects of fieldwork which underlie story telling, first moves, key questions, tricks, listening, looking and synthesis. The author concludes with evaluative criteria for story telling and…

  4. EFFICACY OF TRANEXAMIC ACID IN DECREASING BLOOD LOSS DURING AND AFTER CAESAREAN SECTION: A RANDOMIZED CASE CONTROL PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Tullika

    2014-03-01

    Full Text Available : INTRODUCTION: To reduce maternal mortality and morbidity caused by bleeding, it is important to reduce the amount of bleeding during and after lower segment caesarean section (LSCS. Tranexamic acid helps to reduce bleeding during and after LSCS. OBJECTIVES: To study the efficacy and safety of Tranexamic acid in reducing blood loss during and after Lower segment Caesarean Section (LSCS. METHODS: A randomized case controlled prospective study was conducted on 200 women undergoing lower segment cesarean section. Hundreds of them that were given tranexamic acid immediately before LSCS were compared to hundred others to whom tranexamic acid was not given. Blood loss was collected and measured during the two periods, from plancental delivery to end of LSCS and second from end of LSCS to two hours postpartum. RESULTS: Tranexamic acid significantly reduced the quantity of blood loss from placental delivery to end of LSCS, 202.25ml in the study group vs392.20 ml in the control group (p<0.001; from the end of LSCS, to 2 hours postpartum 3.80ml in the study group versus 112.25ml in the control group (p<0.001; In totality, it significantly reduced the quantity of blood loss from placental delivery to two hours postpartum i.e. 27.05ml in the study group versus 510.45ml in the control group (p < 0.001. No complications or side effects were noted. CONCLUSION: Tranexamic acid significantly reduced the amount of blood loss during and after LSCS. Tranexamic acid can be used prophylactically; moreover it is safer and effective in women undergoing LSCS.

  5. Gamers Telling Stories

    DEFF Research Database (Denmark)

    Albrechtslund, Anne-Mette Bech

    2010-01-01

    of Warcraft , make sense of their gaming experience, and how they build and uphold a community identity by telling stories online. I argue that in studying and conceptualizing these types of texts through the proposed theoretical framework, we can gain insights into the process of the formation of meaning...

  6. Why Tell Stories?

    Science.gov (United States)

    Lockett, Jordan S.; Jones, Rose B.

    2009-01-01

    Storytelling was first developed as a means of transferring important historical information from one generation to another. Though stories are told today more often for entertainment and amusement, the art of storytelling remains of significant value to society. Whether the children are telling the story or simply listening to it, the benefits of…

  7. Manage your blood sugar (image)

    Science.gov (United States)

    Checking your blood sugar levels often and writing down the results will tell you how well you are managing your diabetes so you ... possible. The best times to check your blood sugar are before meals and at bedtime. Your blood ...

  8. Hepcidin is a Better Predictor of Iron Stores in Premenopausal Women than Blood Loss or Dietary Intake

    Directory of Open Access Journals (Sweden)

    Karen H. C. Lim

    2016-09-01

    Full Text Available The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored. This cross-sectional study aimed to identify dietary determinants of iron stores after accounting for blood loss and to determine whether iron intake predicts iron stores independently of hepcidin in a sample of Australian women. Three hundred thirty eight women aged 18–50 years were recruited. Total intake and food sources of iron were determined via food frequency questionnaire; the magnitude of menstrual losses was estimated by self-report; and blood donation volume was quantified using blood donation records and self-reported donation frequency. Serum samples were analysed for ferritin, hepcidin and C-reactive protein concentrations. Linear regression was used to investigate associations. Accounting for blood loss, each 1 mg/day increase in dietary iron was associated with a 3% increase in iron stores (p = 0.027; this association was not independent of hepcidin. Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference <0.001, and increased hepcidin diminished the positive association between iron intake and iron stores. Despite not being the biggest contributor to dietary iron intake, unprocessed meat was positively associated with iron stores, and each 10% increase in consumption was associated with a 1% increase in iron stores (p = 0.006. No other dietary factors were associated with iron stores. Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.

  9. Hepcidin is a Better Predictor of Iron Stores in Premenopausal Women than Blood Loss or Dietary Intake.

    Science.gov (United States)

    Lim, Karen H C; Booth, Alison O; Nowson, Caryl A; Szymlek-Gay, Ewa A; Irving, David O; Riddell, Lynn J

    2016-01-01

    The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored. This cross-sectional study aimed to identify dietary determinants of iron stores after accounting for blood loss and to determine whether iron intake predicts iron stores independently of hepcidin in a sample of Australian women. Three hundred thirty eight women aged 18-50 years were recruited. Total intake and food sources of iron were determined via food frequency questionnaire; the magnitude of menstrual losses was estimated by self-report; and blood donation volume was quantified using blood donation records and self-reported donation frequency. Serum samples were analysed for ferritin, hepcidin and C-reactive protein concentrations. Linear regression was used to investigate associations. Accounting for blood loss, each 1 mg/day increase in dietary iron was associated with a 3% increase in iron stores (p = 0.027); this association was not independent of hepcidin. Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R² of model including hepcidin = 0.65; R² of model excluding hepcidin = 0.17, p for difference <0.001), and increased hepcidin diminished the positive association between iron intake and iron stores. Despite not being the biggest contributor to dietary iron intake, unprocessed meat was positively associated with iron stores, and each 10% increase in consumption was associated with a 1% increase in iron stores (p = 0.006). No other dietary factors were associated with iron stores. Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores. PMID:27598194

  10. A randomized trial of the effect of low dose epinephrine infusion in addition to tranexamic acid on blood loss during total hip arthroplasty

    DEFF Research Database (Denmark)

    Jans, Ø; Grevstad, Jens Ulrik; Mandøe, H;

    2016-01-01

    procedure. Intraoperative tranexamic acid (TXA) was administered to all subjects. The primary outcome was intraoperative blood loss directly measured by drains and weighing swabs. Secondary outcome was total blood loss at 24 h postoperatively calculated using the Gross formula. RESULTS: Of 106 subjects...

  11. Telling the truth.

    OpenAIRE

    Jackson, J

    1991-01-01

    Are doctors and nurses bound by just the same constraints as everyone else in regard to honesty? What, anyway, does honesty require? Telling no lies? Avoiding intentional deception by whatever means? From a utilitarian standpoint lying would seem to be on the same footing as other forms of intentional deception: yielding the same consequences. But utilitarianism fails to explain the wrongness of lying. Doctors and nurses, like everyone else, have a prima facie duty not to lie--but again like ...

  12. Loss of autoregulation of blood flow in subcutaneous tissue in juvenile diabetes

    DEFF Research Database (Denmark)

    Henriksen, O; Kastrup, J; Parving, H H;

    1984-01-01

    and retinopathy. The blood flow remained constant in all normal subjects, when the arterial perfusion pressure was varied between 70 and 150 mm Hg. All diabetics had impaired or reduced autoregulation of the subcutaneous blood flow. The blood flow increased and decreased almost linearly with the changes...... in arterial perfusion pressure. The mechanism underlying the defect autoregulation of blood flow in diabetics is uncertain; possibilities include structural changes of the arterioles and/or alterations of local metabolic factors.......The autoregulation of blood flow in subcutaneous tissue was investigated at the level of the lateral malleolus by the local 133Xenon washout technique. We have investigated eight long-term insulin-dependent diabetics and seven healthy controls. All diabetics had moderate diabetic nephropathy...

  13. Tranexamic acid reduces blood loss during and after cesarean section:A double blinded, randomized, controlled trial

    Institute of Scientific and Technical Information of China (English)

    Amr H Yehia; Magdy H Koleib; Ibrahim A Abdelazim; Ahmed Atik

    2014-01-01

    Objective:To evaluate the efficacy of tranexamic acid in reduction of blood loss during and after cesarean section.Methods:Women included in the current double blinded, randomized, controlled trial were recruited from women attending for elective cesarean section and randomized into two groups; study group: received tranexamic acid with induction of anesthesia plus10IU of oxytocin injection after delivery of the baby.Control group: received only oxytocin 10IU injection after delivery of the baby.Results:Twenty four hours post-operative hemoglobin level was significantly higher in study group(11.2±1.5 mg/dL) compared to control(9.6±1.2 mg/dL), also24 hours post-operative hematocrit was significantly higher in study group(30.2±6.6) compared to control(29.2±2.8).Calculated total blood loss from placental delivery till end of cesarean section was significantly less in study group compared to control(369.5±198.0 versus606.8±193.0 mL; respectively), also, calculated vaginal bleeding during first6 hours post-operative was significantly less in study group compared to control(85.0±30.7 mL versus130.8±49.3 mL, respectively).The incidence of post-partum hemorrhage was significantly less in study group compared to control(31.1% versus63.2%; respectively), also the need for iron replacement therapy was significantly less frequent in study group compared to control(0.9% versus6.6%, respectively). Conclusions:Tranexamic acid can be used safely to reduce blood loss during cesarean section. Reduced blood loss after tranexamic acid was associated with improvement of post-operative hemoglobin, hematocrit and with reduction of post-partum need for iron replacement.

  14. Can local application of Tranexamic acid reduce post-coronary bypass surgery blood loss? A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Latter David

    2009-06-01

    Full Text Available Abstract Background Diffuse microvascular bleeding remains a common problem after cardiac procedures. Systemic use of antifibrinolytic reduces the postoperative blood loss. The purpose of this study was to examine the effectiveness of local application of tranexamic acid to reduce blood loss after coronary artery bypass grafting (CABG. Methods Thirty eight patients scheduled for primary isolated coronary artery bypass grafting were included in this double blind, prospective, randomized, placebo controlled study. Tranexamic acid (TA group (19 patients received 1 gram of TA diluted in 100 ml normal saline. Placebo group (19 patients received 100 ml of normal saline only. The solution was purred in the pericardial and mediastinal cavities. Results Both groups were comparable in their baseline demographic and surgical characteristics. During the first 24 hours post-operatively, cumulative blood loss was significantly less in TA group (median of 626 ml compared to Placebo group (median of 1040 ml (P = 0.04. There was no significant difference in the post-op Packed RBCs transfusion between both groups (median of one unit in each (P = 0.82. Significant less platelets transfusion required in TA group (median zero unit than in placebo group (median 2 units (P = 0.03. Apart from re-exploration for excessive surgical bleeding in one patient in TA group, no difference was found in morbidity or mortality between both groups. Conclusion Topical application of tranexamic acid in patients undergoing primary coronary artery bypass grafting led to a significant reduction in postoperative blood loss without adding extra risk to the patient.

  15. Coagulation competence and fluid recruitment after moderate blood loss in young men

    DEFF Research Database (Denmark)

    Zaar, Morten; Mørkeberg, Jakob; Pott, Frank C;

    2014-01-01

    blood cell count (4.80 ± 0.33 to 4.64 ± 0.37 × 10(12) cells l(-1), P < 0.05) indicating that 218 ± 173 ml fluid was recruited to the circulation. Withdrawing 450 ml blood reduced the time until initial fibrin formation (R: 6.5 ± 0.9 to 5.1 ± 1.0 min, P < 0.01), whereas the rate of clot formation...

  16. How to Tell a Joke

    Institute of Scientific and Technical Information of China (English)

    JosephDeVeto

    2004-01-01

    Do you often tell jokes when you speak English? Very few students even try to do it. There are two reasons for this. One is that they have trouble remembering jokes and stories. The second reason is that they don't tell the jokes in a natural, funny way. Let me show you how you can tell jokes and make people laugh in English.

  17. First Trimester Pregnancy Loss and the Expression of alternatively spliced NKp30 isoforms in Maternal Blood and Placental Tissue

    Directory of Open Access Journals (Sweden)

    Avishai eShemesh

    2015-06-01

    Full Text Available In this study, we aimed to investigate whether first trimester pregnancy loss is associated with differences in expression of NKp30 splice variants (isoforms in maternal peripheral blood or placental tissue. We conducted a prospective case-control study; a total of 33 women undergoing dilation and curettage due to first trimester pregnancy loss were further subdivided into groups with sporadic or recurrent pregnancy loss. The control group was comprised of women undergoing elective termination of pregnancy. The qPCR approach was employed to assess the relative expression of NKp30 isoforms as well as the total expression of NKp30 and NKp46 receptors between the selected groups. Results show that in both PBMC and placental tissue, NKp46 and NKp30 expression was mildly elevated in the pregnancy loss groups compared with the elective group. In particular, NKp46 elevation was significant. Moreover, expression analysis of NKp30 isoforms manifested a different profile between PBMC and the placenta. NKp30-a and NKp30-b isoforms in the placental tissue, but not in PBMC, showed a significant increase in the pregnancy loss groups compared with the elective group. Placental expression of NKp30 activating isoforms -a and -b in the pregnancy loss groups was negatively correlated with PLGF expression. In contrast, placental expression of these isoforms in the elective group was positively correlated with TNFα, IL-10 and VEGF-A expression. The altered expression of NKp30 activating isoforms in placental tissue from patients with pregnancy loss compared to the elective group and the different correlations with cytokine expression point to the involvement of NKp30-mediated function in pregnancy loss.

  18. ROLE OF TRANEXAMIC ACID IN REDUCING POSTOPERATIVE BLOOD LOSS AND TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING LOWER LIMB ORTHOPEDIC SURGERIES

    Directory of Open Access Journals (Sweden)

    Yashwant

    2014-09-01

    Full Text Available AIM: Aim of our study to assess the effects of tranexamic acid (TA in patients undergoing lower limb orthopedic surgeries. OBJECTIVE: Assess the effects of tranexamic acid on prevention of bleeding and requirement of blood transfusion after major lower limb orthopedic surgeries. MATERIAL AND METHOD: 90 patients ASA grade I & II undergoing elective surgery for femoral fracture like open reduction internal fixation, hemiarthroplasty, total hip replacement (THR under anaesthesia were taken. Patients were classified randomly into 2 groups (forty five patients in each group. Group T: Patients received inj. TA 10 mg/kg body weight. Group P: Patients received normal saline 1 ml/kg body weight 15 min before surgery. Postoperative hemoglobin concentration (on day 0 and day 2 and volume of blood in the drain were measured. The number of units of packed red cells transfused during the hospital stay was recorded and any thromboembolic and other complications were documented. RESULT: Analysis revealed that there were no significant differences between the patients with respect to age, sex, duration and type of surgery and preoperative mean hemoglobin concentration. Neither heart rate nor MABP has statistically significant difference or results (P>0.05. The drains were removed in the evening of the first postoperative day. Mean volume of blood in the drain compared to placebo group showing a highly significant reduction in postoperative blood loss (P=0.01. Mean fall in hemoglobin at day 0 and day 2 was 2 less in the study group as compared to the placebo that has P value 0.01 making it significant finding. CONCLUSION: the present paired study demonstrated that the administration of TA given preoperatively reduces the blood loss in the first 24 h by a highly significant degree as well it causes a significant reduction in postoperative anemia and need for transfusion among these patients.

  19. Tell Me……

    Institute of Scientific and Technical Information of China (English)

    孙佳

    2010-01-01

    今年年初.BIGBANG在日本举行了巡演,“ELECTRICLOVETOUR2010”一共6场公演。一共动员了5万人,BIGBANG在日本的人气急速升温。最近,他们的新单曲《TellMeGoodbye》作为TOP主演的《IRIS》的主题曲在日本播放。更是大受欢迎。

  20. Show and Tell

    DEFF Research Database (Denmark)

    2013-01-01

    /DK), Pernille With Madsen, Emil Alenius, Andrés Galeano (E/DE), Kasper Vang & Mads Forsby, Nanna Lysholt Hansen og Molly & Me (Molly Haslund & Catherine Hoffmann (UK)) Kurateret af Judith Schwarzbart og Sanne Krogh Groth Produceret af studerende ved Performance-design Programmet var støttet af Statens Kunstråd...... og studienævnet på Performance-design. Show & Tell - Performance program: kl. 16.30-19 Adresse: Kunsthal Charlottenborg, Nyhavn 2, 1051 København K...

  1. Telling the truth.

    Science.gov (United States)

    Jackson, J

    1991-03-01

    Are doctors and nurses bound by just the same constraints as everyone else in regard to honesty? What, anyway, does honesty require? Telling no lies? Avoiding intentional deception by whatever means? From a utilitarian standpoint lying would seem to be on the same footing as other forms of intentional deception: yielding the same consequences. But utilitarianism fails to explain the wrongness of lying. Doctors and nurses, like everyone else, have a prima facie duty not to lie--but again like everyone else, they are not duty-bound to avoid intentional deception, lying apart; except where it would involve a breach of trust.

  2. Telling life stories.

    Science.gov (United States)

    Sorrell, Jeanne M; Butler, Frieda R

    2009-11-01

    A life review has been demonstrated to be highly beneficial to well or chronically ill older adults, as well as terminally ill older adults. Those living independently indicate feelings of relief and connectivity after telling their stories. Further, terminally ill patients at the end of their lives express feelings of peacefulness at being able to put pieces of their lives together in a meaningful way. It is well known that physicians and nurses have received inadequate training in how to address end-of-life issues. The life review process can be an important strategy for fostering helpful communication between health care professionals and older adults in all phases of health and illness.

  3. The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy

    Science.gov (United States)

    Majid, I.; Alshryda, S.; Somanchi, B.; Morakis, E.; Foster, A.

    2015-01-01

    This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized. PMID:26664830

  4. The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    I. Majid

    2015-01-01

    Full Text Available This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.. More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized.

  5. Medical image of the week: pneumatosis intestinalis secondary to massive acute blood loss

    Directory of Open Access Journals (Sweden)

    Assar S

    2013-10-01

    Full Text Available The patient was a 32 year-old male with a past medical history significant for end stage liver disease secondary to severe alcoholism who was found with an altered mental status. In the emergency department, the patient divulged he had been throwing up blood clots in the preceding days. Shortly into his presentation he began throwing up voluminous bright red blood. Initial hemoglobin concentration was 2.8 mg/dL. CT scan of the abdomen revealed pneumatosis within the ascending colon, small bowel, and mesenteric veins. Despite massive transfusion efforts and two episodes of successful cardiac resuscitation the patient expired.

  6. Use of recombinant activated factor VII for reduction of perioperative blood loss during elective surgical correction of spine deformity in a Jehovah's Witness. Case report.

    Science.gov (United States)

    Kącka, Katarzyna; Kącki, Wojciech; Merak, Joanna; Błęka, Adam

    2010-01-01

    Planned surgical procedures at patients who refuse allogenic blood transfusion because of religious convictions are important problem, not only medical but also ethical and juristical. At the study authors report the successful use of activated recombinant factor VII (rFVIIa) for the reduction of perioperative blood loss in four years old child - Jehovah's Witness, who had planned Torode kyphectomy. Applied perioperative management together with preparing to surgery with erythropoietin allowed for reduction of blood loss and avoiding of blood transfusion. Authors state, that appropriate perioperative proceeding makes a possibility of safe surgical procedures also at patients who refuse the transfusion. PMID:21057153

  7. Anesthetic management of a patient with 10 l of blood loss during operation for a retroperitoneal mass

    Directory of Open Access Journals (Sweden)

    Xueqin Zhu

    2015-04-01

    Full Text Available Bleeding is a common problem during resection of a retroperitoneal mass. Massive bleeding may occur in case of injury of an adjacent major vessel or organ. This case report describes a successful anesthetic management of a patient with 10 l of blood loss within three hours surgery. A 44-year-old woman who underwent an operation for resection of a retroperitoneal mass, went to a hypovolemic shock, due to acute life-threatening intra-operative bleeding, and was successfully rescued with a combination of measures, including control of surgical bleeding, supportive treatment with rapid fluid infusion, massive transfusion of blood products and administration of intravenous vasoactive agents for maintaining tissue perfusion and oxygenation, utilizing intraoperative autologous blood salvaged via cell saver, as well as prevention and treatment of complications. The patient received a total of 22 units of Packet Red Blood Cells (PRBCs, 18 units of Fresh Frozen Plasma (FFP, 10 units of cryoprecipitate, 3750 ml of her own salvage blood. Postoperatively, she was transferred to the intensive care unit (ICU with mechanical ventilator support, where she received another 5.4 units of FFP, 10 units of cryoprecipitate. The patient developed features of early acute lung injury such as fever and hypoxemia, and was managed successfully with mechanical ventilator support for a few days. At a three-month follow-up, the patient was doing very well. This paper explores the pathogenesia, implications, prevention and treatment of the transfusion-associated complications such as acidosis, hypothermia, electrolyte abnormalities, and transfusion-related acute lung injury (TRALI. Particular attention is given to the prevention of secondary coagulopathy of the patient requiring massive blood transfusion. This case study presents a good reference for similar anesthetic scenario in the future.

  8. Relaxation and Visualization Strategies for Story Telling

    Institute of Scientific and Technical Information of China (English)

    冯灵林

    2012-01-01

    The importance of training students to tell or retell story is self - evident for mastering English language. The following activity introduces relaxation and visualization strategies for story telling.

  9. Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss

    DEFF Research Database (Denmark)

    Engberink, M F; Geleijnse, J M; Bakker, S J L;

    2015-01-01

    Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss...... in 420 overweight adults from the Diet, Obesity and Genes study. After an 8-week weight-loss period (>8% BW), subjects (42±6 years) were randomized to either a high-protein diet (23-28 en% protein) or a lower-protein control diet (10-15 en% protein) for 26 weeks. BMI after weight loss was 30.3±4.3 kg m......(-2), BP was 118/73 mm Hg and 28 subjects (6.5%) used antihypertensive agents. Systolic BP during 26 weeks of weight maintenance dietary intervention increased in both treatment groups, but it was 2.2 mm Hg less (95% CI: -4.6 to 0.2 mm Hg, P=0.08) in the high-protein group than in the lower...

  10. COMPARISON OF HAEMODYNAMICS AND BLOOD LOSS IN URETHROPLASTY SURGERIES DONE UNDER GENERAL ANAESTHESIA WITH AND WITHOUT CAUDAL BLOCK IN CHILDREN AGED BETWEEN 2–5 YRS

    Directory of Open Access Journals (Sweden)

    Aavula

    2015-12-01

    Full Text Available Urethroplasty surgery is a painful procedure demanding high doses of analgesics, which may be associated with adverse effects and associated with significant blood loss. Caudal blockade provides good analgesia and hemodynamic stability and is probably a useful supplement in these surgeries. OBJECTIVES To compare the heart rate, blood pressure response to surgical stimuli and the incidence of blood transfusion rate post-operatively between 2 groups – A General Anaesthesia only. B General Anaesthesia with caudal block. SETTINGS AND DESIGN Study was conducted in 100 children, randomly divided into two groups A and B. Only ASA grade 1 patients aged 2-5yrs. undergoing urethroplasty for hypospadias were included. MATERIALS AND METHODS 1ml/kg of 0.125% bupivacaine was used for caudal blockade in group B (GA+CAUDAL and compared with group A (Only GA. Heart rate and blood pressure were recorded for every 5 min. Blood loss and requirement of blood transfusions were recorded at the end of the surgery. RESULTS There were statistically significant haemodynamic changes and blood transfusion requirement during surgery in group A. In Group B haemodynamic parameters were stable (P value 0 and blood transfusion requirement was also less (p value 0.00054 (P<0.01. CONCLUSION Caudal blockade when supplemented with general anaesthesia reduces blood loss, decreases requirement for blood transfusion and maintains haemodynamic stability.

  11. Teaching ethics: telling stories.

    Science.gov (United States)

    Bowman, A

    1995-02-01

    In order to develop moral literacy, nursing students should be exposed both to traditional rules and justice-based ethics, and to a feminist care perspective. Justice and truth are not objective and abstract, but are embedded in context and are relative in nature. Nurses may be given the tools with which to analyse and understand ethical dilemmas from a justice-based view and an opportunity to tell their stories in order to understand the roles, motives, relational considerations and contextual influences on decision outcomes. If we are serious about our desire to raise critical consciousness of students and nurses in practice, we must attend to and join feminists in their attempts to validate women's ways of knowing, to assist women to question their contexts, and to put aside preconceived positions and notions about moral reasoning among women. PMID:7708027

  12. Coblation tonsillectomy versus dissection tonsillectomy: a comparison of intraoperative time, intraoperative blood loss and post-operative pain.

    Science.gov (United States)

    Izny Hafiz, Z; Rosdan, S; Mohd Khairi, M D

    2014-04-01

    The objective of this study was to compare the intraoperative time, intraoperative blood loss and post operative pain between coblation tonsillectomy and cold tonsillectomy in the same patient. A prospective single blind control trial was carried out on 34 patients whom underwent tonsillectomy. The patients with known bleeding disorder, history of unilateral peritonsillar abscess and unilateral tonsillar hypertrophy were excluded. Operations were done by a single surgeon using cold dissection tonsillectomy in one side while coblation tonsillectomy in the other. Intraoperative time, intraoperative blood loss and post operative pain during the first 3 days were compared between the two methods. Results showed that the intraoperative time was significantly shorter (pcoblation tonsillectomy as compared to cold tonsillectomy. Post operative pain score was significantly less at 6 hours post operation (pcoblation tonsillectomy as compared to cold tonsillectomy. However, there were no differences in the post operative pain scores on day 1, 2 and 3. In conclusion, coblation tonsillectomy does have superiority in improving intraoperative efficiency in term of intraoperative time and bleeding compared to cold dissection tonsillectomy. The patient will benefit with minimal post operative pain in the immediate post surgery duration.

  13. Abdominal insufflation decreases blood loss without worsening the inflammatory response: implications for prehospital control of internal bleeding.

    Science.gov (United States)

    Velmahos, George C; Spaniolas, Konstantinos; Tabbara, Malek; Duggan, Michael; Li, Yongqing; De Moya, Marc; Alam, Hasan B

    2008-04-01

    Abdominal insufflation (AI) by carbon dioxide has been shown to decrease the rate of bleeding in different swine models of abdominal organ injuries. With development of appropriate tools, AI could be used to control bleeding temporarily in the prehospital setting. Concerns have been raised about the inflammatory response to AI, which could damage organs at a later stage despite initial hemostasis. We hypothesized that AI controls bleeding without inducing an unfavorable inflammatory response. An experimental splenic injury was caused in 28 Yorkshire pigs, which were randomized to: 1) standard resuscitation (n = 14) with crystalloids to a mean arterial pressure of 60 mm Hg, or 2) standard resuscitation and AI (n = 14) to an abdominal pressure of 20 cmH2O. The experiment lasted for 30 minutes, and intra-abdominal blood loss was measured. Blood serum interleukin 1beta (IL-1beta), transforming growth factor beta1, and lung tissue heat shock protein 70 gene expression were measured at 0, 15, and 30 minutes, as markers of the inflammatory response. All animals survived to the end of the experiment. Total blood loss was significantly less in the AI group compared with the other standard resuscitation animals (733 +/- 76 vs 1094 +/- 153 mL, P = 0.049). The pH at the end of the experiment was significantly lower in the AI group (7.28 +/- 0.02 vs 7.44 +/- 0.05, P < 0.01) but there was no difference in lactate levels (1.5 +/- 0.4 vs 1.7 +/- 0.3, P = 0.7). Similarly, there was no difference in IL-1beta, transforming growth factor beta1, or lung tissue heat shock protein 70 gene expression between the two groups at any time point, although there was a trend towards lower IL-1beta levels in the AI group. Our conclusion is that AI reduces blood loss from splenic injury without a measurable effect on the early inflammatory response in a clinically relevant animal model.

  14. MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis.

    Science.gov (United States)

    Navarathna, Dhammika H M L P; Munasinghe, Jeeva; Lizak, Martin J; Nayak, Debasis; McGavern, Dorian B; Roberts, David D

    2013-09-01

    Disseminated candidiasis primarily targets the kidneys and brain in mice and humans. Damage to these critical organs leads to the high mortality associated with such infections, and invasion across the blood-brain barrier can result in fungal meningoencephalitis. Candida albicans can penetrate a brain endothelial cell barrier in vitro through transcellular migration, but this mechanism has not been confirmed in vivo. MRI using the extracellular vascular contrast agent gadolinium diethylenetriaminepentaacetic acid demonstrated that integrity of the blood-brain barrier is lost during C. albicans invasion. Intravital two-photon laser scanning microscopy was used to provide the first real-time demonstration of C. albicans colonizing the living brain, where both yeast and filamentous forms of the pathogen were found. Furthermore, we adapted a previously described method utilizing MRI to monitor inflammatory cell recruitment into infected tissues in mice. Macrophages and other phagocytes were visualized in kidney and brain by the administration of ultrasmall iron oxide particles. In addition to obtaining new insights into the passage of C. albicans across the brain microvasculature, these imaging methods provide useful tools to study further the pathogenesis of C. albicans infections, to define the roles of Candida virulence genes in kidney versus brain infection and to assess new therapeutic measures for drug development.

  15. Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study

    NARCIS (Netherlands)

    Engberink, M.F.; Geleijnse, J.M.; Bakker, S.J.L.; Larsen, T.

    2015-01-01

    Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss i

  16. Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss : the DiOGenes randomized study

    NARCIS (Netherlands)

    Engberink, M. F.; Geleijnse, J. M.; Bakker, S. J. L.; Larsen, T. M.; Handjieva-Darlesnka, T.; Kafatos, A.; Martinez, J. A.; Pfeiffer, A. F. H.; Kunesova, M.; Jebb, S. A.; Holst, C.; Astrup, A.; Saris, W. H. M.; Brink, E. J.; van Baak, M. A.

    2015-01-01

    Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss i

  17. Measuring Post-Partum Haemorrhage in Low-Resource Settings: The Diagnostic Validity of Weighed Blood Loss versus Quantitative Changes in Hemoglobin

    Science.gov (United States)

    Atukunda, Esther Cathyln; Mugyenyi, Godfrey Rwambuka; Obua, Celestino; Atuhumuza, Elly Bronney; Musinguzi, Nicholas; Tornes, Yarine Fajardo; Agaba, Amon Ganaafa; Siedner, Mark Jacob

    2016-01-01

    Background Accurate estimation of blood loss is central to prompt diagnosis and management of post-partum hemorrhage (PPH), which remains a leading cause of maternal mortality in low-resource countries. In such settings, blood loss is often estimated visually and subjectively by attending health workers, due to inconsistent availability of laboratory infrastructure. We evaluated the diagnostic accuracy of weighed blood loss (WBL) versus changes in peri-partum hemoglobin to detect PPH. Methods Data from this analysis were collected as part of a randomized controlled trial comparing oxytocin with misoprostol for PPH (NCT01866241). Blood samples for complete blood count were drawn on admission and again prior to hospital discharge or before blood transfusion. During delivery, women were placed on drapes and had pre-weighed sanitary towels placed around their perineum. Blood was then drained into a calibrated container and the sanitary towels were added to estimate WBL, where each gram of blood was estimated as a milliliter. Sensitivity, specificity, negative and positive predictive values (PPVs) were calculated at various blood volume loss and time combinations, and we fit receiver-operator curves using blood loss at 1, 2, and 24 hours compared to a reference standard of haemoglobin decrease of >10%. Results A total of 1,140 women were enrolled in the study, of whom 258 (22.6%) developed PPH, defined as a haemoglobin drop >10%, and 262 (23.0%) had WBL ≥500mL. WBL generally had a poor sensitivity for detection of PPH (85%) in high prevalence settings when WBL exceeds 750mL. Conclusion WBL has poor sensitivity but high specificity compared to laboratory-based methods of PPH diagnosis. These characteristics correspond to a high PPV in areas with high PPH prevalence. Although WBL is not useful for excluding PPH, this low-cost, simple and reproducible method is promising as a reasonable method to identify significant PPH in such settings where quantifiable red cell

  18. Measuring Post-Partum Haemorrhage in Low-Resource Settings: The Diagnostic Validity of Weighed Blood Loss versus Quantitative Changes in Hemoglobin.

    Directory of Open Access Journals (Sweden)

    Esther Cathyln Atukunda

    Full Text Available Accurate estimation of blood loss is central to prompt diagnosis and management of post-partum hemorrhage (PPH, which remains a leading cause of maternal mortality in low-resource countries. In such settings, blood loss is often estimated visually and subjectively by attending health workers, due to inconsistent availability of laboratory infrastructure. We evaluated the diagnostic accuracy of weighed blood loss (WBL versus changes in peri-partum hemoglobin to detect PPH.Data from this analysis were collected as part of a randomized controlled trial comparing oxytocin with misoprostol for PPH (NCT01866241. Blood samples for complete blood count were drawn on admission and again prior to hospital discharge or before blood transfusion. During delivery, women were placed on drapes and had pre-weighed sanitary towels placed around their perineum. Blood was then drained into a calibrated container and the sanitary towels were added to estimate WBL, where each gram of blood was estimated as a milliliter. Sensitivity, specificity, negative and positive predictive values (PPVs were calculated at various blood volume loss and time combinations, and we fit receiver-operator curves using blood loss at 1, 2, and 24 hours compared to a reference standard of haemoglobin decrease of >10%.A total of 1,140 women were enrolled in the study, of whom 258 (22.6% developed PPH, defined as a haemoglobin drop >10%, and 262 (23.0% had WBL ≥500mL. WBL generally had a poor sensitivity for detection of PPH (85% in high prevalence settings when WBL exceeds 750mL.WBL has poor sensitivity but high specificity compared to laboratory-based methods of PPH diagnosis. These characteristics correspond to a high PPV in areas with high PPH prevalence. Although WBL is not useful for excluding PPH, this low-cost, simple and reproducible method is promising as a reasonable method to identify significant PPH in such settings where quantifiable red cell indices are unavailable.

  19. Hemostatic strategies for minimizing mortality in surgery with major blood loss

    DEFF Research Database (Denmark)

    Johansson, Per Ingemar

    2009-01-01

    receiving a high fresh frozen plasma (FFP):RBC or platelet:RBC ratio have improved survival, with patients receiving both high FFP:RBC and platelet:RBC ratios exhibiting the highest survival rate. When whole blood thrombelastography is used to guide transfusion therapy in massively bleeding patients......, an increase in FFP and platelet to RBC ratio is also seen, and this is associated with improved survival. This indicates that thrombelastography is better than conventional coagulation assays to monitor coagulopathy and predict transfusion requirements in massive bleeders. SUMMARY: Implementation of more...... aggressive hemostatic resuscitation strategies in massively bleeding patients seems reasonable, and optimally, thrombelastography should be used to monitor coagulopathy and guide FFP and platelet transfusions....

  20. Intra-articular injection of tranexamic acid via a drain plus drain-clamping to reduce blood loss in cementless total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    Mutsuzaki Hirotaka

    2012-09-01

    Full Text Available Abstract Background Patients undergoing cementless total knee arthroplasty (TKA sometimes suffer large blood loss. In a retrospective study, we explored whether postoperative intra-articular retrograde injection of tranexamic acid (TA and leaving a drain clamp in place for 1 h reduced blood loss. Patients and methods Patients (n = 140 treated with unilateral primary cementless TKA (posterior cruciate ligament retained were divided into two groups: those who had an intra-articular injection of TA (1000 mg and drain clamping for 1 h postoperatively (study group, n = 70 and those who were not given TA and did not undergo clamping of their drains (control group, n = 70. Postoperative total blood loss, volume of drainage, hemoglobin level, transfusion amounts and rates, D-dimer level at postoperative day (POD 7, and complications were recorded. Results Total blood loss, total drainage, mean transfusion volume, and transfusion rates were lower in the study group than in controls (P P P  Conclusions Immediately postoperative intra-articular retrograde injection of TA and 1 h of drain-clamping effectively reduced blood loss and blood transfusion after cementless TKA. We believe that this method is simple, easy, and suitable for these patients.

  1. Prophylactic use of tranexamic acid combined with thrombelastogram guided coagulation management may reduce blood loss and allogeneic transfusion in pediatric hemispherectomy: case series.

    Science.gov (United States)

    Xiao, Wei; Fu, Wenya; Wang, Tianlong; Zhao, Lei

    2016-09-01

    Hemispherectomy is an established surgical procedure to treat medically refractory epilepsy caused by diffuse hemispheric diseases. The most common complication of hemispherectomy is intraoperative bleeding. Perioperative allogeneic blood transfusion increases mortality and morbidity in pediatric patients. Etiologies of massive blood loss during hemispherectomy include intraoperative diffuse vascular damage, antileptic drugs induced coagulation dysfunction, hyperfibrinolysis and dilutional coagulopathy. Great efforts should be made to minimize the need of blood transfusion. We present a series of three cases undergoing pediatric hemispherectomy, where a new algorithm was employed to manage coagulation. This new algorithm was mainly based on timely thrombelastogram analyses guided clotting factors supplement and continuous administration of tranexamic acid. In our cases, the amount of blood loss and subsequent allogeneic blood transfusion seemed to be less than literature reported. PMID:27555151

  2. 临产凝血四项检测与产时失血量的相关性研究%Research on the Relationship Between the Detection of 4 Indicators of Blood Coagulation and Blood Loss in Labor

    Institute of Scientific and Technical Information of China (English)

    梁荣伟; 兰枝; 杨善业; 刘新雄; 宁儒凤

    2012-01-01

    [Objective] To explore the relationship between 4 indicators of blood coagulation and blood loss of pregnant women during the labor. [Methods]Totally 2000 pregnant women in obstetric department of our hospital were selected and divided into natural delivery group and cesarean section group with 1000 cases in each group. Prenatal automated coagulation analyzer was used to detect 4 indicators of blood coagulation. Maternal bleeding volume of parturients at labor was estimated by obstetricians. The relationship between 4 indicators of blood coagulation and blood loss was analyzed. [Results] There was no relationship between 4 indicators of blood coagulation at labor and blood loss during natural delivery and cesarean section( P >0. 05) , while the abnormal rate of 4 prenatal indicators of blood coagulation had obvious relation with intrapartum hemorrhage( P 0.05),而产前凝血四项结果异常率与产时出血量多少有明显的相关性(P<0.05);同一孕妇四项结果异常项目越多产程大出血的几率越高.[结论]产前凝血四项结果异常率与产时出血量有一定的相关性,同一孕妇四项结果异常率与出血量明显相关,临床应给予高度重视.

  3. Comparative gastrointestinal blood loss associated with placebo, aspirin, and nabumetone as assessed by radiochromium (/sup 51/Cr)

    Energy Technology Data Exchange (ETDEWEB)

    Lussier, A.; Davis, A.; Lussier, Y.; Lebel, E.

    1989-03-01

    Nabumetone differs from most other nonsteroidal anti-inflammatory drugs. It is presented to the gut as a nonacidic prodrug, and is metabolized to its active form after absorption. Studies in animals and humans suggest it is less irritating to the gastrointestinal mucosa. This study compared the gastrointestinal microbleeding induced by nabumetone to aspirin (acetylsalicylic acid, ASA), and placebo in a double blind parallel study using chromium /sup 51/Cr labelled red cells to quantitate fecal blood loss (FBL) in healthy volunteers. Thirty subjects were randomized to treatment with nabumetone (2000 mg), ASA (3.6 g) or placebo for 21 days following a 7 day placebo period. Six subjects served as untreated controls. FBL in nabumetone treated subjects was not significantly different to placebo or untreated subjects. In contrast, ASA-treated subjects exhibited significantly increased FBL than the other 3 groups (P less than .0001).

  4. Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study

    Directory of Open Access Journals (Sweden)

    Endres Stefan

    2011-11-01

    Full Text Available Abstract Background Degenerative spinal stenosis and instability requiring multilevel spine surgery has been associated with large blood losses. Factors that affect perioperative blood loss include time of surgery, surgical procedure, patient height, combined anterior/posterior approaches, number of levels fused, blood salvage techniques, and the use of anti-fibrinolytic medications. This study was done to evaluate the efficacy of tranexamic acid in reducing blood loss in spine surgery. Methods This retrospective case control study includes 97 patients who had to undergo surgery because of degenerative lumbar spinal stenosis and instability. All operations included spinal decompression, interbody fusion and posterior instrumentation (4-5 segments. Forty-six patients received 1 g tranexamic acid intravenous, preoperative and six hours and twelve hours postoperative; 51 patients without tranexamic acid administration were evaluated as a control group. Based on the records, the intra- and postoperative blood losses were measured by evaluating the drainage and cell saver systems 6, 12 and 24 hours post operation. Additionally, hemoglobin concentration and platelet concentration were reviewed. Furthermore, the number of red cell transfusions given and complications associated with tranexamic acid were assessed. Results The postoperative hemoglobin concentration demonstrated a statistically significant difference with a p value of 0.0130 showing superiority for tranexamic acid use (tranexamic acid group: 11.08 g/dl, SD: 1.68; control group: 10.29 g/dl, SD: 1.39. The intraoperative cell saver volume and drainage volume after 24 h demonstrated a significant difference as well, which indicates a less blood loss in the tranexamic acid group than the control group. The postoperative drainage volume at12 hours showed no significant differences; nor did the platelet concentration Allogenic blood transfusion (two red cell units was needed for eight patients

  5. High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.

    Science.gov (United States)

    Quaranta, Nicola; Squeo, Valentina; Sangineto, Moris; Graziano, Giusi; Sabbà, Carlo

    2015-01-01

    Idiopathic sudden sensorineural hearing loss (ISSHL) is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL), total cholesterol (TC) and apolipoprotein B (Apo-B) have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients' blood sampling and hearing assessments were carried out. Patients were divided into two groups as "recovered" and "unrecovered", according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03). None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.

  6. High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.

    Directory of Open Access Journals (Sweden)

    Nicola Quaranta

    Full Text Available Idiopathic sudden sensorineural hearing loss (ISSHL is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL, total cholesterol (TC and apolipoprotein B (Apo-B have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients' blood sampling and hearing assessments were carried out. Patients were divided into two groups as "recovered" and "unrecovered", according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03. None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.

  7. A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA to epsilon aminocaproic acid (EACA for corrective spinal surgery

    Directory of Open Access Journals (Sweden)

    Vaz Kenneth M

    2010-04-01

    Full Text Available Abstract Background Multilevel spinal fusion surgery has typically been associated with significant blood loss. To limit both the need for transfusions and co-morbidities associated with blood loss, the use of anti-fibrinolytic agents has been proposed. While there is some literature comparing the effectiveness of tranexamic acid (TXA to epsilon aminocaproic acid (EACA in cardiac procedures, there is currently no literature directly comparing TXA to EACA in orthopedic surgery. Methods/Design Here we propose a prospective, randomized, double-blinded control study evaluating the effects of TXA, EACA, and placebo for treatment of adolescent idiopathic scoliosis (AIS, neuromuscular scoliosis (NMS, and adult deformity (AD via corrective spinal surgery. Efficacy will be determined by intraoperative and postoperative blood loss. Other clinical outcomes that will be compared include transfusion rates, preoperative and postoperative hemodynamic values, and length of hospital stay after the procedure. Discussion The primary goal of the study is to determine perioperative blood loss as a measure of the efficacy of TXA, EACA, and placebo. Based on current literature and the mechanism by which the medications act, we hypothesize that TXA will be more effective at reducing blood loss than EACA or placebo and result in improved patient outcomes. Trial Registration ClinicalTrials.gov ID: NCT00958581

  8. Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: a preliminary study.

    Science.gov (United States)

    Newberg, Andrew B; Wintering, Nancy; Khalsa, Dharma S; Roggenkamp, Hannah; Waldman, Mark R

    2010-01-01

    This preliminary study determined if subjects with memory loss problems demonstrate changes in memory and cerebral blood flow (CBF) after a simple 8-week meditation program. Fourteen subjects with memory problems had an IV inserted and were injected with 250 MBq of Tc-99m ECD while listening to a neutral stimulus CD. They then underwent a pre-program baseline SPECT scan. Then subjects were guided through their first meditation session with a CD, during which they received an injection of 925 MBq ECD, and underwent a pre-program meditation scan. Subjects completed an 8-week meditation program and underwent the same scanning protocol resulting in a post-program baseline and meditation scan. A region of interest (ROI) template obtained counts in each ROI normalized to whole brain to provide a CBF ratio. Baseline and meditation scans and neuropsychological testing were compared before and after the program. The meditation program resulted in significant increases (pmemory showed improvements after training. This preliminary study evaluated whether an 8-week meditation program resulted in improvements in neuropsychological function and differences in CBF in subjects with memory loss. While the findings are encouraging, there are a number of limitations that can be addressed in future studies with more participants and more detailed analyses.

  9. Blood profile of proteins and steroid hormones predicts weight change after weight loss with interactions of dietary protein level and glycemic index.

    Directory of Open Access Journals (Sweden)

    Ping Wang

    Full Text Available BACKGROUND: Weight regain after weight loss is common. In the Diogenes dietary intervention study, high protein and low glycemic index (GI diet improved weight maintenance. OBJECTIVE: To identify blood predictors for weight change after weight loss following the dietary intervention within the Diogenes study. DESIGN: Blood samples were collected at baseline and after 8-week low caloric diet-induced weight loss from 48 women who continued to lose weight and 48 women who regained weight during subsequent 6-month dietary intervention period with 4 diets varying in protein and GI levels. Thirty-one proteins and 3 steroid hormones were measured. RESULTS: Angiotensin I converting enzyme (ACE was the most important predictor. Its greater reduction during the 8-week weight loss was related to continued weight loss during the subsequent 6 months, identified by both Logistic Regression and Random Forests analyses. The prediction power of ACE was influenced by immunoproteins, particularly fibrinogen. Leptin, luteinizing hormone and some immunoproteins showed interactions with dietary protein level, while interleukin 8 showed interaction with GI level on the prediction of weight maintenance. A predictor panel of 15 variables enabled an optimal classification by Random Forests with an error rate of 24±1%. A logistic regression model with independent variables from 9 blood analytes had a prediction accuracy of 92%. CONCLUSIONS: A selected panel of blood proteins/steroids can predict the weight change after weight loss. ACE may play an important role in weight maintenance. The interactions of blood factors with dietary components are important for personalized dietary advice after weight loss. REGISTRATION: ClinicalTrials.gov NCT00390637.

  10. "Telling" Truths: Wounded Truths and the Activity of Truth Telling

    Science.gov (United States)

    Harwood, Valerie

    2004-01-01

    It appears that being young and queer seems to be all about woundedness: it means experiencing suffering, including the risk of suicide, increased drug use, homelessness and violence. Yet how are these wounded truths told, and further, why is it that people in education seem to tell them "unproblematically"? This paper considers these questions by…

  11. 成分输血对急性失血患者酸碱平衡的影响%The acid-base balance influence of blood component transfusion on acute blood loss patients

    Institute of Scientific and Technical Information of China (English)

    吴胜楠; 洪澄英; 温隽珉; 周志强; 赖旭春

    2009-01-01

    目的:探讨成分输血对急性失血患者酸碱平衡的影响.方法:对88例急性失血患者进行输血前及输血后定时血气分析监测,根据血气监测结果分析成分输血对酸碱平衡的影响.结果:观察期间14例患者存在其他影响酸碱平衡因素退出.纳入分析的74例中,44例输血前存在不同程度代谢性酸中毒的患者输血后26例酸中毒消失,17例减轻,1例略加重.74例患者中输血后发生输血相关性碱中毒24例,其24 h内新鲜冰冻血浆(FFP)平均用量2 063 ml,明显高于非碱中毒患者.输血相关性碱中毒的病例未使用酸性药物进行治疗,停止输血后13~48 h自动恢复.结论:急性失血患者输血前大部分存在程度不同的代谢性酸中毒,经有效止血、输血后多能缓解.成分输血对急性失血患者酸碱平衡的影响主要表现为代谢性碱中毒,代谢性酸中毒罕见.输血相关性碱中毒一般为自限性,停止输血后可自行恢复.%Objective:To investigate the acid-base balance influence of blood component transfusion on acute blood loss patients. Methods:We detected the blood gas analysis of 88 acute blood loss patients before and after blood component transfusion, to analyze the acid-base balance influence of blood component transfusion according to the blood gas analysis. Results:Fourteen patients were quit for the acid-base balance influence of other factors during the observation, Seventy-four patients were bring into the acid-base balance analysis; Among the forty-four patients with different degree acidosis before, Twenty-six patient's acidosis vanished after blood component transfusion,Seventeen patient's acidosis alleviated af-ter blood componenttransfusion, One patient's acidosis aggravated slightly after blood component transfusion;Twenty-four patients had blood transfusion relevent alkalosis in all seventy-four patients after transfusion, And their average usage amount of fresh frozen plasma (FFP) was 2 063

  12. Ghost-Story Telling: Keeping It Appropriate.

    Science.gov (United States)

    Weintraub, Jeff

    1996-01-01

    Guidelines for telling ghost stories at camp involve considering children's fears at different ages, telling age appropriate stories, determining appropriate times for telling ghost stories, and minimizing fear when a child becomes frightened by a ghost story. Includes tips on the selection, preparation, and presentation of ghost stories. (LP)

  13. EFFICACY OF TRANEXAMIC ACID IN DECREASING BLOOD LOSS DURING AND AFTER CAESAREAN SECTION IN MULTIGRAVIDA PARTURIENTS: A CASE CONTROLLED PROSPECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Gunavathi Kandappan

    2016-06-01

    Full Text Available OBJECTIVES To study the efficacy of Tranexamic acid in reducing blood loss during and after the lower segment caesarean section in Multigravida parturients. METHODOLOGY A case controlled prospective study was conducted in 50 multigravida parturient women undergoing elective lower segment caesarean section in our hospital after getting Institutional Ethical Committee approval, over a period of two months. 25 of them were given Tranexamic acid 15 mg/kg immediately before caesarean section. Blood loss was collected and measured during two periods. The first period was from placental delivery to end of LSCS and the second from the end LSCS to 2 hours postpartum. RESULTS Tranexamic acid significantly reduces the quantity of blood loss from the end of LSCS to 2 hours post-partum in multigravida parturients. No complications or side effects are noted in both the groups. CONCLUSION Tranexamic acid significantly reduces the amount of blood loss during and after the lower segment caesarean section in multigravida parturients and its use was not associated with any side effects or complications.

  14. Telling a Great Story. Programming.

    Science.gov (United States)

    Cameron, Sandy

    1998-01-01

    Storytelling can help campers build confidence and enhance their communication skills. Techniques include choosing a short, familiar story; learning major points and retelling in one's own words; introducing the story; practicing facial expressions, gestures, voice inflections, and body movements; and telling the story in a small group in a quiet…

  15. Food Labels Tell the Story!

    Science.gov (United States)

    ... My World From the Label to the Table! Food Labels Tell the Story! What is in food? Food provides your body with all of the ... your food choices. Nutrition Facts—the Labels on Food Products Beginning in 1994, the US government began ...

  16. Relationship of hidden blood loss, implants and sex during the perioperative treatment of elderly intertrochanteric fracture Relationship of hidden blood loss, implants and sex during the perioperative treatment of elderly intertrochanteric fracture%老年股骨转子间骨折围修复期隐性失血量与内固定植入物及性别的关系

    Institute of Scientific and Technical Information of China (English)

    王峰; 李振武; 尹锐锋; 李志安

    2016-01-01

    BACKGROUND: With the continuous renewal and development of clinical repair techniques, the intraoperatie blood loss has been greatly reduced in the treatment of intertrochanteric fracture; however, no matter what kind of repair methods should be adopted, there are stil a large amount of perioperative hidden blood loss, however, there are few clinical reports for the reasons and related factors. OBJECTIVE: To study the correlation of perioperative hidden blood loss with gender and internal fixation methods in the surgery of elderly femoral intertrochanteric fractures.METHODS: Total y 121 patients with elderly femoral intertrochanteric fractures who received the treatment at Department of Orthopedics, Nanyang City Center Hospital from March 2010 to June 2013 were divided into two groups according to the condition and treatment wishes of patients, and were respectively treated with dynamic hip screw and proximal femoral anti-rotation intramedul ary nail internal fixation. The preoperative hidden blood loss, postoperative hidden blood loss, the total hidden blood loss, dominant blood loss and total blood loss of patients in these two groups were compared. The multiple linear regression analysis on the correlation of perioperative hidden blood loss with gender and internal fixation methods was conducted. RESULTS AND CONCLUSION: There was no significant difference in the preoperative hidden blood loss between these two groups (P > 0.05). The total blood loss, postoperative hidden blood loss and total hidden blood loss in the proximal femoral anti-rotation intramedul ary nail group were significantly higher than those in the dynamic hip screw group (P 0.05);股骨近端防旋髓内钉组患者的总失血量、治疗后隐性失血量及总隐性失血量均明显高于动力髋螺钉组(P <0.05),而显性失血量明显低于动力髋螺钉组(P <0.05)。治疗前、治疗后隐性失血量及总隐性失血量男性均显著低于女性

  17. Correlation between the coverage percentage of prosthesis and postoperative hidden blood loss in primary total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    Gao Fuqiang; Guo Wanshou; Sun Wei; Li Zirong; Wang Weiguo; Wang Bailiang; Cheng Liming

    2014-01-01

    Background The aim of this study was to determine the relationship between prosthesis coverage and postoperative hidden blood loss (HBL) in primary total knee arthroplasty (TKA).Methods A total of 120 patients who had undergone unilateral TKA from August 2012 to May 2013 were retrospectively studied.The Gross formula was used to calculate the amount of HBL.Routine standard anteroposterior (AP) and lateral x-ray films of the knee joint were taken postoperatively and used to measure the percentages of coronal femoral and of coronal and sagittal tibial prosthetic coverage.Then Pearson's correlation analysis was performed to assess the correlations between the percentages of prosthetic coverage for each AP and lateral position and HBL on the first and third postoperative days.Results The volumes of HBL on the first and third postoperative days after TKA were (786.5±191.6) ml and (1 256.6±205.1) ml,respectively,and lateral x-ray film measurements of percentages of coronal femoral,tibial coronal,and sagittal prosthetic coverage were (87.9±2.5)%,(88.5±2.2)%,and (89.1±2.3)%,respectively.Pearson's correlation analysis showed statistically significant correlations between percentages of total knee prosthetic coverage for each AP and lateral position and volumes of HBL on the first and third postoperative days (P <0.05).Conclusions HBL after TKA correlates with degree of prosthetic coverage.To some extent,the size of the surfaces exposed by osteotomy determines the amount of HBL.Choice of the appropriate prosthesis can significantly reduce postoperative HBL.Designing individualized prostheses would be a worthwhile development in joint replacement surgery.

  18. Pentylentetrazole-induced loss of blood-brain barrier integrity involves excess nitric oxide generation by neuronal nitric oxide synthase.

    Science.gov (United States)

    Danjo, Sonoko; Ishihara, Yasuhiro; Watanabe, Masatomo; Nakamura, Yu; Itoh, Kouichi

    2013-09-12

    Dysfunction of the blood-brain barrier (BBB) is one of the major pathophysiological consequences of epilepsy. The increase in the permeability caused by BBB failure is thought to contribute to the development of epileptic outcomes. We developed a method by which the BBB permeability can be demonstrated by gadolinium-enhanced T1 weighted imaging (GdET1WI). The present study examined the changes in the BBB permeability in mice with generalized convulsive seizures (GCS) induced by acute pentylentetrazole (PTZ) injection. At 15min after PTZ-induced GCS, the BBB temporarily leaks BBB-impermeable contrast agent into the parenchyma of the diencephalon, hippocampus and cerebral cortex in mice, and the loss of BBB integrity was gradually recovered by 24h. The temporary BBB failure is a critical link to the glutamatergic activities that occur following the injection of PTZ. PTZ activates the glutamatergic pathway via the NMDA receptor, then nitric oxide (NO) is generated by NMDA receptor-coupled neuronal NO synthase (nNOS). To examine the influence of nNOS-derived NO induced by PTZ on the increases of the BBB permeability, GdET1WI was performed using conventional nNOS gene-deficient mice with or without PTZ injection. The failure of the BBB induced by PTZ was completely protected by nNOS deficiency in the brain. These results suggest that nNOS-derived excess NO in the glutamatergic pathway plays a key role in the failure of the BBB during PTZ-induced GCS. The levels of NO synthetized by nNOS in the brain may represent an important target for the future development of drugs to protect the BBB. PMID:23831997

  19. Presenting Data And Telling Stories

    Science.gov (United States)

    Eales, Philip; Wayne, Andrew; Tildsley, Kevin M.; Wilkinson, Tim; Prieto, Diego Fernandez

    2013-12-01

    Earth observation data are now readily available at a range of scales and becoming increasingly familiar to the general public. Observations built up over several decades enable us to show long-term change and tell increasingly complex stories about the Earth and other planets. Data visualisation and computer graphics can help present these stories to a non-specialist public audience. In addition to high visual quality and clear design, we have found it useful to present data within its geographical and scientific context, in natural colour, in a realistic and immersive environment, using familiar visual and physical metaphors. The internet increasingly allows direct communication with the public and this places renewed emphasis on basics such as good story-telling. Examples are shown of work in television, print and digital media, and from ESA's Earth observation and planetary exploration programmes.

  20. Die betroubaarheid van saamgestelde tellings

    OpenAIRE

    J. M. Schepers

    1993-01-01

    The reliability of composite scores. A formula for estimating the reliability of composite scores is developed on the basis of the formal definition of reliability. This formula is less restricting than Cronbach's alpha coefficient and Spearman and Brown's prophecy formula. It is similar to Mosier's Formula 18, but uses less information. The application of the formula is illustrated with real data. Opsomming 'n Formule om die betroubaarheid van saamgestelde tellings te beraam, is aan die han...

  1. Analysis of predonation loss of blood donors due to deferrals - in a tertiary care hospital set up

    OpenAIRE

    Shreedevi S Bobati; Vijaya Basavraj; Pallavi Prakash

    2016-01-01

    Context: Blood is a living tissue that is transfused into another human body and hence blood safety is a major issue in transfusion medicine. It is well-known that a large number of apparently healthy donors are deferred from successful blood donation because of varied reasons. They are the potential motivated donors the society is losing. Hence, it is very important to analyze the reasons for deferral and retain the motivated donors. Aims: The objective of this study was to determine the...

  2. Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis

    OpenAIRE

    WANG, Meng; Zheng, Xin-Feng; Jiang, Lei-Sheng

    2015-01-01

    Background Routine use of antifibrinolytic agents in spine surgery is still an issue of debate. Objective To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA, traditionally known as Amicar) in reducing perioperative blood loss and transfusion requirements in scoliosis surgery. Methods We conducted a systematic review and meta-analysis for randomized controlled trials (RCTs), retrosp...

  3. Effect of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery: a randomized, clinical trial

    OpenAIRE

    Shao, Hua; Kuang, Li-Ting; Hou, Wei-Jian; Zhang,Tao

    2015-01-01

    Background Bleeding during functional endoscopic sinus surgery is a challenge for the quality of the surgical field for surgeons. This study aimed to evaluate the effect of desmopressin premedication on blood loss and the quality of the surgical field in endoscopic sinus surgery. Methods A total of 90 American Society of Anesthesiologists physical status I–II patients underwent endoscopic sinus surgery for chronic sinusitis. They were randomly allocated to receive either desmopressin 0.3 μg/k...

  4. The Telling Takes Us Home

    Science.gov (United States)

    Lazic, G. M.

    2013-04-01

    Carl Sagan reminded us in Cosmos that we have wondered about the stars for as long as we have been human. “Star tellers” like Von Del Chamberlain and Lynn Moroney remind us that, for just as long, we have been telling stories about the stars to explain what we observed. This presentation describes methods of reuniting science and storytelling as complementary approaches to comprehending the cosmos. Examples illustrate how stories can serve as “springboards,” inspire their listeners to new awareness, and involve astronomy educators as reporters, tellers, and mediators.

  5. The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty

    Science.gov (United States)

    Yuan, Z. F.; Yin, H.; Xing, D. L.

    2016-01-01

    Objectives Tranexamic acid (TXA) is an antifibrinolytic agent used as a blood-sparing technique in total knee arthroplasty (TKA), and is routinely administered by intravenous (IV) or intra-articular (IA) injection. Recently, a novel method of TXA administration, the combined IV and IA application of TXA, has been applied in TKA. However, the scientific evidence of combined administration of TXA in TKA is still meagre. This meta-analysis aimed to investigate the efficacy and safety of combined IV and IA TXA in patients undergoing TKA. Materials and Methods A systematic search was carried out in PubMed, the Cochrane Clinical Trial Register (Issue12 2015), Embase, Web of Science and the Chinese Biomedical Database. Only randomised controlled trials (RCT) evaluating the efficacy and safety of combined use TXA in TKA were identified. Two authors independently identified the eligible studies, extracted data and assessed the methodological quality of included studies. Meta-analysis was conducted using Review Manager 5.3 software. Results A total of ten RCTs (1143 patients) were included in this study. All the included studies were randomised and the quality of included studies still needed improvement. The results indicated that, compared with either placebo or the single-dose TXA (IV or IA) group, the combination of IV and IA TXA group had significantly less total blood loss, hidden blood loss, total drain output, a lower transfusion rate and a lower drop in haemoglobin level. There were no statistically significant differences in complications such as wound infection and deep vein thrombosis between the combination group and the placebo or single-dose TXA group. Conclusions Compared with placebo or the single-dose TXA, the combined use of IV and IA TXA provided significantly better results with respect to all outcomes related to post-operative blood loss without increasing the risk of thromboembolic complications in TKA. Cite this article: Z. F. Yuan, H. Yin, W. P. Ma

  6. Bodily Synchronization Underlying Joke Telling

    Directory of Open Access Journals (Sweden)

    R. C. Schmidt

    2014-08-01

    Full Text Available Advances in video and time series analysis have greatly enhanced our ability to study the bodily synchronization that occurs in natural interactions. Past research has demonstrated that the behavioral synchronization involved in social interactions is similar to dynamical synchronization found generically in nature. The present study investigated how the bodily synchronization in a joke telling task is spread across different nested temporal scales. Pairs of participants enacted knock-knock jokes and times series of their bodily activity were recorded. Coherence and relative phase analyses were used to evaluate the synchronization of bodily rhythms for the whole trial as well as at the subsidiary time scales of the whole joke, the setup of the punch line, the two-person exchange and the utterance. The analyses revealed greater than chance entrainment of the joke teller’s and joke responder’s movements at all time scales and that the relative phasing of the teller’s movements led those of the responder at the longer time scales. Moreover, this entrainment was greater when visual information about the partner’s movements was present but was decreased particularly at the shorter time scales when explicit gesturing in telling the joke was performed. In short, the results demonstrate that a complex interpersonal bodily dance occurs during structured conversation interactions and that this dance is constructed from a set of rhythms associated with the nested behavioral structure of the interaction.

  7. Mathematical tablets from Tell Harmal

    CERN Document Server

    Gonçalves, Carlos

    2015-01-01

    This work offers a re-edition of twelve mathematical tablets from the site of Tell Harmal, in the borders of present-day Baghdad. In ancient times, Tell Harmal was Šaduppûm, a city representative of the region of the Diyala river and of the kingdom of Ešnunna, to which it belonged for a time. These twelve tablets were originally published in separate articles in the beginning of the 1950s and mostly contain solved problem texts. Some of the problems deal with abstract matters such as triangles and rectangles with no reference to daily life, while others are stated in explicitly empirical contexts, such as the transportation of a load of bricks, the size of a vessel, the number of men needed to build a wall and the acquisition of oil and lard. This new edition of the texts is the first to group them, and takes into account all the recent developments of the research in the history of Mesopotamian mathematics. Its introductory chapters are directed to readers interested in an overview of the mathematical con...

  8. The Effect of Radioactive Lantern Mantle Powder and Bentonite-Zeoloite Minerals on the Volume of Blood Loss, Bleeding and Clotting Time

    Directory of Open Access Journals (Sweden)

    M Atefi

    2009-04-01

    Full Text Available ABSTRACT Introduction & Objective: Over the past decade the US army has widely studied new technologies for stopping sever hemorrhages and has introduced an effective Zeolite based hemostatic agent. On the other hand, Mortazavi and his colleagues previously reported the bio-stimulatory effects of the topical application of radioactive lantern mantle powder on wound healing. Their subsequent studies showed significant changes in some histological parameters concerning healing. In this light, here the bio-stimulatory effect of burned radioactive lantern mantles powder as well as two minerals bentonite and zeolite are presented. Materials & Methods: This experimental study was conducted in the center for radiological studies, Shiraz University of Medical Sciences in 2008. Fifty male Wistar rats were divided randomly into 5 groups of 10 animals each. Following anesthesia, animals’ tails were cut at a thickness of 5 mm by using a surgical scissor. No intervention was made on the animals of the 1st group. The 2nd to 4th group received topical non-radioactive lantern mantle powder, radioactive lantern mantle powder, Bentonite mineral or a mixture of Bentonite-Zeoliteat minerals respectively. After treatment with above mentioned agents, the volume of blood loss was measured using a scaled test-tube. The bleeding time and clotting time were also measured using a chronometer. SPSS software was used for statistical analysis. ANOVA was used for comparing the means of each parameter in the 5 groups. Results: The the volume of blood loss, bleeding and clotting times in control animals were 4.39±1.92 cc, 112.10±39.60 sec and 94.9±54.26 sec, respectively. In the 5th group in which the animals were treated with a mixture of Bentonite-Zeoliteat minerals, the volume of blood loss, bleeding and clotting times were 1.31±0.60 cc, 34.50±4.65 sec and 24.2±4.61 sec, respectively. Conclusion: This is the 1st investigation that studied the alterations of bleeding

  9. Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells or Their Conditioned Medium Prevents Bone Loss in Ovariectomized Nude Mice

    OpenAIRE

    An, Jee Hyun; Park, Hyojung; Song, Jung Ah; Ki, Kyung Ho; Yang, Jae-Yeon; Choi, Hyung Jin; Cho, Sun Wook; Kim, Sang Wan; Kim, Seong Yeon; Yoo, Jeong Joon; Baek, Wook-Young; Kim, Jung-Eun; Choi, Soo Jin; Oh, Wonil; Shin, Chan Soo

    2013-01-01

    Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in stem cell therapy. We studied the effects of systemic injection of human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss in nude mice. Ten-week-old female nude mice were divided into six groups: Sham-operated mice treated with vehicle (Sham-Vehicle), OVX mice subjected to UCB-MSCs (OVX-MSC), or human dermal fibroblast (OVX-DFB) transplantation, ...

  10. Use of Tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement

    Directory of Open Access Journals (Sweden)

    Umer Chaudhry Muhammad

    2011-05-01

    Full Text Available Abstract Background & Purpose Allogenic blood transfusion in elective orthopaedic surgery is best avoided owing to its associated risks. Total knee replacement often requires blood transfusion, more so when bilateral surgery is performed. Many strategies are currently being employed to reduce the amount of peri-operative allogenic transfusions. Anti-fibrinolytic compounds such as aminocaproic acid and tranexamic acid have been used systemically in perioperative settings with promising results. This study aimed to evaluate the effectiveness of tranexamic acid in reducing allogenic blood transfusion in total knee replacement surgery. Methodology This was a retrospective cohort study conducted on patients undergoing total knee replacement during the time period November 2005 to November 2008. Study population was 99 patients, of which 70 underwent unilateral and 29 bilateral knee replacement. Forty-seven patients with 62 (49.5% knees (group-I had received tranexamic acid (by surgeon preference while the remaining fifty-two patients with 66 (51.5% knees (group-II had did not received any tranexamic acid either pre- or post-operatively. Results The mean drop in the post-operative haemoglobin concentration in Group-II for unilateral and bilateral cases was 1.79 gm/dl and 2.21 gm/dl, with a mean post-operative drainage of 1828 ml (unilateral and 2695 ml (bilateral. In comparison, the mean drop in the post-op haemoglobin in Group-I was 1.49 gm/dl (unilateral and 1.94 gm/dl (bilateral, with a mean drainage of 826 ml (unilateral and 1288 ml (bilateral (p-value Interpretation Tranexamic acid is effective in reducing post-operative drainage and requirement of blood transfusion after knee replacement.

  11. Relationships Between Selected Gene Polymorphisms and Blood Pressure Sensitivity to Weight Loss in Elderly Persons With Hypertension

    OpenAIRE

    Kostis, William J; Cabrera, Javier; Hooper, W. Craig; Whelton, Paul K.; Espeland, Mark A.; Cosgrove, Nora M.; Cheng, Jerry Q; Deng, Yingzi; De Staerck, Christine; Pyle, Meredith; Maruthur, Nisa; Reyes, Ingrid; Anderson, Cheryl A. M.; Liu, Jie; Kostis, John B

    2013-01-01

    Salt sensitivity, the heterogeneity in the response of blood pressure (BP) to alterations in sodium intake, has been studied extensively, whereas weight sensitivity, the heterogeneity in BP response to weight change, has received scant attention. We examined the relationship of 21 gene polymorphisms previously found to be associated with hypertension, diabetes mellitus, or obesity, with weight sensitivity in the Trial of Nonpharmacologic Interventions in the Elderly, where participants with h...

  12. CO2 blood test

    Science.gov (United States)

    Bicarbonate test; HCO3-; Carbon dioxide test; TCO2; Total CO2; CO2 test - serum ... Many medicines can interfere with blood test results. Your health care provider will tell you if you need to stop taking any medicines before you have this test. DO ...

  13. Comparison of Effects of Labetalol and Nitroglycerine on Intraoperative Blood Loss and Surgical Field Quality in Rhinoplasty Surgery

    OpenAIRE

    Hadavi, Mohamad Reza; Zarei, Yadollah; Tarogh, Shojaolhagh

    2015-01-01

    BACKGROUND Rhinoplasty is one of the most common surgeries of the plastic surgery and as well as ear, throat and nose. Intra-operative bleeding during surgery is one of the most important factors that may impair the surgeon’s job. Providing a clean blood-free surgical filed makes the operation faster, easier and with a better quality. One way to achieve this goal is to induce hypotension. This study aimed to compare the impacts and outcomes of administration of labetalol or nitroglycerin for ...

  14. Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Meng Wang

    Full Text Available Routine use of antifibrinolytic agents in spine surgery is still an issue of debate.To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA and epsilon aminocaproic acid (EACA, traditionally known as Amicar in reducing perioperative blood loss and transfusion requirements in scoliosis surgery.We conducted a systematic review and meta-analysis for randomized controlled trials (RCTs, retrospective case-control studies, and retrospective cohort studies on the use of antifibrinolytic agents in scoliosis surgery by searching in the MEDLINE and EMBASE databases and the Cochrane Database of Systematic Reviews and Controlled Trials of papers published from January 1980 through July 2014. Safety of the antifibrinolytic agents was evaluated in all included studies, while efficacy was evaluated in RCTs.Eighteen papers with a total of 1,158 patients were eligible for inclusion in this study. Among them, 8 RCTs with 450 patients were included for evaluation of pharmacologic efficacy (1 RCT was excluded because of a lack of standard deviation data. Mean blood loss was reduced in patients with perioperative use of antifibrinolytic agents by 409.25 ml intraoperatively (95% confidence interval [CI], 196.57-621.94 ml, 250.30 ml postoperatively (95% CI, 35.31-465.30, and 601.40 ml overall (95% CI, 306.64-896.16 ml. The mean volume of blood transfusion was reduced by 474.98 ml (95% CI, 195.30-754.67 ml. The transfusion rate was 44.6% (108/242 in the patients with antifibrinolytic agents and 68.3% (142/208 in the patients with placebo. (OR 0.38; 95% CI; 0.25-0.58; P<0.00001, I2 = 9%. All studies were included for evaluation of safety, with a total of 8 adverse events reported overall (4 in the experimental group and 4 in the control group.The systematic review and meta-analysis indicated that aprotinin, TXA, and EACA all significantly reduced perioperative blood loss and transfusion requirements

  15. Novel application of pre-operative vertebral body embolization to reduce intraoperative blood loss during a three-column spinal osteotomy for non-oncologic spinal deformity.

    Science.gov (United States)

    Tuchman, Alexander; Mehta, Vivek A; Mack, William J; Acosta, Frank L

    2015-04-01

    Three column osteotomies (3CO) of the lumbar spine are powerful corrective procedures used in the treatment of kyphoscoliosis. Their efficacy comes at the cost of high reported complication rates, notably significant estimated blood loss (EBL). Previously reported techniques to reduce EBL have had modest efficacy. Here we describe a potential technique to decrease EBL during pedicle subtraction osteotomy (PSO) of the lumbar spine by means of pre-operative vertebral body embolization - a technique traditionally used to reduce blood loss prior to spinal column tumor resection. We present a 62-year-old man with iatrogenic kyphoscoliosis who underwent staged deformity correction. Stage 1 involved thoracolumbar instrumentation followed by transarterial embolization of the L4 vertebral body through bilateral segmental arteries. A combination of polyvinyl alcohol particles and Gelfoam (Pfizer, New York, NY, USA) were used. Following embolization there was decreased angiographic blood flow to the small vessels of the L4 vertebral body, while the segmental arteries remained patent. Stage 2 consisted of an L4 PSO and fusion. The EBL during the PSO procedure was 1L, which compared favorably to that during previous PSO at this institution as well as to quantities reported in previous literature. There have been no short term (5 month follow-up) complications attributable to the vertebral body embolization or surgical procedure. Although further investigation into this technique is required to better characterize its safety and efficacy in reducing EBL during 3CO, we believe this patient illustrates the potential utility of pre-operative vertebral embolization in the setting of non-oncologic deformity correction surgery. PMID:25564274

  16. Hidden blood loss in total knee arthroplasty under high negative pressure drainage%全膝关节置换后高负压引流下的隐性失血

    Institute of Scientific and Technical Information of China (English)

    喻长纯; 杨明路; 杜兴升

    2013-01-01

    背景:通常评价关节置换患者出血量主要是记录置换中的出血量和置换后的引流量,这些只是显性失血量,研究表明隐性失血量可达到并超过总量的50%。  目的:比较全膝关节置换高负压引流和普通负压引流失血量,评价高负压引流对全膝关节置换隐性失血的影响。  方法:60例单侧全膝人工关节置换患者根据置换后采用的负压吸引不同分为高负压引流组和普通负压引流组(对照组),每组30例。通过Gross方程推算,对膝关节置换后总失血量(显性失血量+隐性失血最)和输血量进行分析,并对两组置换后并发症及功能恢复状况进行比较。  结果与结论:高负压引流组患者总失血量为(646±184) mL,隐性失血量为(215±128) mL;对照组患者总失血量为(867±296) mL,隐性失血量(457±268) mL;高负压引流组总失血量及隐性失血量均明显少于对照组(P METHODS:A total of 60 patients undergoing lateral total knee arthroplasty were equal y divided into high negative pressure drainage group and conventional drainage group (control group). We calculated the total blood loss (dominant blood loss and hidden blood loss) and blood transfusion amount with the Gross equation. The recovery after surgery and complications were compared. RESULTS AND CONCLUSION:In high negative pressure drainage group, the total blood loss was (646±184) mL and the hidden blood loss was (215±128) mL. In the control group, the total blood loss was (867±296) mL and the hidden blood loss was (457±268) mL. The total blood loss and hidden blood loss in the high negative pressure drainage group were significantly less than those in the control group (P<0.05). The average blood transfusion amount was 224 mL in the high negative pressure drainage group and 467 mL in the control group. Fol owing unilateral total knee arthroplasty, total blood loss, hidden blood loss and blood transfusion

  17. BRCA1 loss pre-existing in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood

    Energy Technology Data Exchange (ETDEWEB)

    Bednarz, Natalia; Eltze, Elke; Semjonow, Axel; Rink, Michael; Andreas, Antje; Mulder, Lennart; Hannemann, Juliane; Fisch, Margit; Pantel, Klaus; Weier, Heinz-Ulrich G.; Bielawski, Krzysztof P.; Brandt, Burkhard

    2010-03-19

    A recent study concluded that serum prostate specific antigen (PSA)-based screening is beneficial for reducing the lethality of PCa, but was also associated with a high risk of 'overdiagnosis'. Nevertheless, also PCa patients who suffered from organ confined tumors and had negative bone scans succumb to distant metastases after complete tumor resection. It is reasonable to assume that those tumors spread to other organs long before the overt manifestation of metastases. Our current results confirm that prostate tumors are highly heterogeneous. Even a small subpopulation of cells bearing BRCA1 losses can initiate PCa cell regional and distant dissemination indicating those patients which might be at high risk of metastasis. A preliminary study performed on a small cohort of multifocal prostate cancer (PCa) detected BRCA1 allelic imbalances (AI) among circulating tumor cells (CTCs). The present analysis was aimed to elucidate the biological and clinical role of BRCA1 losses on metastatic spread and tumor progression in prostate cancer patients. Experimental Design: To map molecular progression in PCa outgrowth we used FISH analysis of tissue microarrays (TMA), lymph node sections and CTC from peripheral blood. We found that 14% of 133 tested patients carried monoallelic BRCA1 loss in at least one tumor focus. Extended molecular analysis of chr17q revealed that this aberration was often a part of larger cytogenetic rearrangement involving chr17q21 accompanied by AI of the tumor suppressor gene PTEN and lack of the BRCA1 promoter methylation. The BRCA1 losses correlated with advanced T stage (p < 0.05), invasion to pelvic lymph nodes (LN, p < 0.05) as well as BR (p < 0.01). Their prevalence was twice as high within 62 LN metastases (LNMs) as in primary tumors (27%, p < 0.01). The analysis of 11 matched primary PCa-LNM pairs confirmed the suspected transmission of genetic abnormalities between those two sites. In 4 of 7 patients with metastatic disease, BRCA1

  18. Pregnancy Loss in Dairy Cattle: Relationship of Ultrasound, Blood Pregnancy-Specific Protein B, Progesterone and Production Variables.

    Science.gov (United States)

    Gábor, G; Kastelic, J P; Abonyi-Tóth, Z; Gábor, P; Endrődi, T; Balogh, O G

    2016-08-01

    Objectives were to determine associations between percentage pregnancy loss (PPL) in dairy cattle and: (i) pregnancy diagnosis by ultrasonography; (ii) pregnancy diagnosis by serum pregnancy-specific protein B (PSPB) concentrations, with or without serum progesterone concentrations; and (iii) production and environmental factors. This study included 149 822 pregnancy diagnoses conducted over 13 years in Holstein-Friesian cows in Hungarian dairy herds. The following were determined: PPL in cows diagnosed pregnant by transrectal ultrasonography 29-42 days after artificial insemination (AI; n = 11 457); PPL in cows diagnosed pregnant by serum PSPB 29-35 days after AI (n = 138 365); and PPL and its association with serum progesterone concentrations, PSPB and production/environmental variables. The definition of PPL was percentage of cows initially diagnosed pregnant based on ultrasonography or PSPB, but not pregnant when examined by transrectal palpation 60 -70 days after AI. The PPL was lower (p 1.1 ng/ml) was lowest (15.0%), whereas cows with low concentrations of both PSPB and progesterone (0.6-1.1 and advanced parity and with high milk production, when ambient temperatures were high, although body condition score (BCS) had no effect on PPL. Finally, there were no significant associations between serum PSPB and environmental temperatures or number of post-partum uterine treatments.

  19. Pregnancy Loss in Dairy Cattle: Relationship of Ultrasound, Blood Pregnancy-Specific Protein B, Progesterone and Production Variables.

    Science.gov (United States)

    Gábor, G; Kastelic, J P; Abonyi-Tóth, Z; Gábor, P; Endrődi, T; Balogh, O G

    2016-08-01

    Objectives were to determine associations between percentage pregnancy loss (PPL) in dairy cattle and: (i) pregnancy diagnosis by ultrasonography; (ii) pregnancy diagnosis by serum pregnancy-specific protein B (PSPB) concentrations, with or without serum progesterone concentrations; and (iii) production and environmental factors. This study included 149 822 pregnancy diagnoses conducted over 13 years in Holstein-Friesian cows in Hungarian dairy herds. The following were determined: PPL in cows diagnosed pregnant by transrectal ultrasonography 29-42 days after artificial insemination (AI; n = 11 457); PPL in cows diagnosed pregnant by serum PSPB 29-35 days after AI (n = 138 365); and PPL and its association with serum progesterone concentrations, PSPB and production/environmental variables. The definition of PPL was percentage of cows initially diagnosed pregnant based on ultrasonography or PSPB, but not pregnant when examined by transrectal palpation 60 -70 days after AI. The PPL was lower (p 1.1 ng/ml) was lowest (15.0%), whereas cows with low concentrations of both PSPB and progesterone (0.6-1.1 and <2 ng/ml, respectively) had the highest PPL (76.3%; p < 0.0001). Furthermore, PPL was higher in cows with advanced parity and with high milk production, when ambient temperatures were high, although body condition score (BCS) had no effect on PPL. Finally, there were no significant associations between serum PSPB and environmental temperatures or number of post-partum uterine treatments. PMID:27198072

  20. Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: a pilot study.

    Science.gov (United States)

    White, Andrea M; Johnston, Carol S; Swan, Pamela D; Tjonn, Sherrie L; Sears, Barry

    2007-10-01

    Ketogenic diets have been associated with reductions in free-living physical activity, a response that can be counterproductive in individuals trying to lose weight. To explore whether popular low-carbohydrate diets might impact the desire to exercise by raising blood ketone concentrations, fatigue and perceived effort during exercise were compared in untrained, overweight adults adhering to a ketogenic low-carbohydrate diet or to a control diet low in carbohydrate, but not ketogenic (5%, 65%, and 30% or 40%, 30%, and 30% of energy from carbohydrate, fat, and protein, respectively). In this prospective, randomized, 2-week pilot study, all meals and snacks were provided to subjects, and energy intake was strictly controlled to provide approximately 70% of that needed for weight maintenance. At baseline and at the end of week 2, exercise testing was conducted in fasting participants. Weight loss and the reductions in fat mass did not differ by group during the trial. At week 2, blood beta-hydroxybutyrate concentrations were 3.6-fold greater for the ketogenic vs nonketogenic group (P=0.018) and correlated significantly with perceived exercise effort (r2=0.22, P=0.049). Blood beta-hydroxybutyrate was also significantly correlated to feelings of "fatigue" (r=0.458, P=0.049) and to "total mood disturbance" (r=0.551, P=0.015) while exercising. These pilot data indicate that ketogenic, low-carbohydrate diets enhance fatigability and can reduce the desire to exercise in free-living individuals. PMID:17904939

  1. Tiny Molybdenites Tell Diffusion Tales

    Science.gov (United States)

    Stein, H. J.; Hannah, J. L.

    2014-12-01

    Diffusion invokes micron-scale exchange during crystal growth and dissolution in magma chambers on short time-scales. Fundamental to interpreting such data are assumptions on magma-fluid dynamics at all scales. Nevertheless, elemental diffusion profiles are used to estimate time scales for magma storage, eruption, and recharge. An underutilized timepiece to evaluate diffusion and 3D mobility of magmatic fluids is high-precision Re-Os dating of molybdenite. With spatially unique molybdenite samples from a young ore system (e.g., 1 Ma) and a double Os spike, analytical errors of 1-3 ka unambiguously separate events in time. Re-Os ages show that hydrous shallow magma chambers locally recharge and expel Cu-Mo-Au-silica as superimposed stockwork vein networks at time scales less than a few thousand years [1]. Re-Os ages provide diffusion rates controlled by a dynamic crystal mush, accumulation and expulsion of metalliferous fluid, and magma reorganization after explosive crystallization events. Importantly, this approach has broad application far from ore deposits. Here, we use Re-Os dating of molybdenite to assess time scales for generating and diffusing metals through the deep crust. To maximize opportunity for chemical diffusion, we use a continental-scale Sveconorwegian mylonite zone for the study area. A geologically constrained suite of molybdenite samples was acquired from quarry exposures. Molybdenite, previously unreported, is extremely scarce. Tiny but telling molybdenites include samples from like occurrences to assure geologic accuracy in Re-Os ages. Ages range from mid-Mesoproterozoic to mid-Neoproterozoic, and correspond to early metamorphic dehydration of a regionally widespread biotite-rich gneiss, localized melting of gneiss to form cm-m-scale K-feldspar ± quartz pods, development of vapor-rich, vuggy mm stringers that serve as volatile collection surfaces in felsic leucosomes, and low-angle (relative to foliation) cross-cutting cm-scale quartz veins

  2. The LHCb DAQ interface board TELL1

    Science.gov (United States)

    Haefeli, G.; Bay, A.; Gong, A.; Gong, H.; Muecke, M.; Neufeld, N.; Schneider, O.

    2006-05-01

    We have developed an electronic board (TELL1) to interface the DAQ system of the LHCb experiment at CERN. 289 TELL1 boards are needed to read out the different subdetectors. Each board can handle either 64 analog or 24 digital optical links. The TELL1 mother board provides common mode correction, zero suppression, data formatting, and a large network interface buffer. To satisfy the different requirements we have adopted a flexible FPGA design and made use of mezzanine cards. Mezzanines are used for data input from digital optical and analog copper links as well as for the Gigabit Ethernet interface to DAQ. The LHCb timing and trigger control signals are transported by a dedicated optical link, while the board slow-control is provided by an embedded PC running a Linux kernel.

  3. Telling Successes of Japanese Foreign Aid

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    and social as well as the economic impact. This paper is an analysis of who tell the stories, how they tell them, and variations within the stories in terms of content and focus. By combining the ‘who’ of individual, community, and national impact and the nature of impact with the agency of the people who...... tell about the successes, the paper illustrates and argues that the impact of foreign aid can be measured in many ways beyond economic growth. However, in order for a diverse impact to become measurable, we need the historians’ attention to individual stories over long periods of time. Institutions......Stakeholders of two success story events negotiated an idea of development as individual entrepreneurship. The sixty-five-year-old Japanese Foreign Aid history includes stories of successes told by professionals from developing countries throughout the world. Their stories reflect the cultural...

  4. 人工关节置换术隐性失血量及其相关因素分析%Hidden blood loss after artificial joint replacement and its correlation analysis

    Institute of Scientific and Technical Information of China (English)

    李洪飞; 吕德成; 张卫国; 张羽飞

    2011-01-01

    Objective To calculate the volume and to study the correlated risk factors of hidden blood loss after artificial hip or knee joint replacement. Methods From July to November in 2008, 38patients with age of (65.11±13.51) years old were treated with artificial hip or knee joint replacement, and were divided by age into four groups. Using Gross formula, total blood loss was calculated depending on height, weight and pre- and post-operation hematocrit, and the hidden blood loss was acquired by subtracting the visible blood loss from the total blood loss. The correlation between age,body mass index( BMI),gender and hidden blood blood loss was observed. Differences of hidden blood loss of artificial hip or knee joint replacement were compared. Results The total blood loss of all arthroplasties was ( 1563.52 ± 693.10) ml,and the hidden blood loss was (538.70 ± 529.77) ml,the percentage of hidden blood loss was 33%. The hidden blood loss was inversely related to age (P< 0.05 ). There was no correlation between BMI and hidden blood loss (P>0.05). The percentage of hidden blood loss in total blood loss in woman was significantly higher than that in man. With age and gender paired, the percentage of hidden blood loss in total blood loss in artificial hip joint replacement was significantly higher than that in artificial knee joint replacement (P<0.05 ). Conclusions Both of age and gender are risk factors influencing hidden blood loss after artificial hip or knee joint replacement. And compared with artificial knee joint replacement, the percentage of hidden blood loss in artificial hip joint replacement is higher.%目的 通过计算人工髋关节置换术和人工膝关节置换术隐性失血量,分析其相关的危险因素,并探讨其发生机制.方法 2008年7-11月行人工关节置换术38例,年龄(65.11±13.51)岁,其中人工髋关节置换术25例,人工膝关节置换术13例.根据身高、体质指数和手术前后的红细胞压积计算总失血

  5. Decrease in symptoms, blood loss and uterine size with nafarelin acetate before abdominal hysterectomy: a placebo-controlled, double-blind study.

    Science.gov (United States)

    Ylikorkala, O; Tiitinen, A; Hulkko, S; Kivinen, S; Nummi, S

    1995-06-01

    To evaluate the efficacy and safety of nafarelin before hysterectomy in a prospective placebo-controlled trial, we randomized 188 pre-menopausal women with uterine fibroids (n = 111), menometrorrhagia (n = 58) or pelvic pain (n = 19) to receive either nafarelin (200 micrograms twice daily as a nasal spray) or a placebo for 3 months before abdominal hysterectomy. The data analysis could be performed in 166 women, of whom 107 received nafarelin and 59 a placebo. Nafarelin led to a rise in blood haemoglobin (5.5 g/l) and to a decrease in uterine volume (23.7%). This, however, gave no objective benefit during surgery (similar operative durations and blood losses). The uteri from patients treated with nafarelin (255.5 +/- 12.6 g, mean +/- SD) were significantly lighter (P = 0.029) than those from patients treated with a placebo (346.2 +/- 35.7 g). Histological examination of the fibroids or uteri revealed changes typical for hypo-oestrogenism, but no specific histological pattern could be established. The endometrium was proliferative in 56% and showed mild hyperplastic features in 10% of patients given nafarelin, whereas the respective figures for the placebo group were 41 and 0%. Hot flushes were the most common side-effects, being reported by 61% in the nafarelin group and 35% in the placebo group. Nafarelin can be useful as a pre-surgical adjunct in a patient scheduled for abdominal hysterectomy if there is a need to raise the haemoglobin concentration or to reduce the size of the uterus. PMID:7593517

  6. Morphological dependency of cutaneous blood flow and sweating during compensable heat stress when heat-loss requirements are matched across participants.

    Science.gov (United States)

    Notley, Sean R; Park, Joonhee; Tagami, Kyoko; Ohnishi, Norikazu; Taylor, Nigel A S

    2016-07-01

    Human heat loss is thought, in part, to be morphologically related. It was therefore hypothesized that when heat-loss requirements and body temperatures were matched, that the mass-specific surface area alone could significantly explain both cutaneous vascular and sudomotor responses during compensable exercise. These thermoeffector responses were examined in 36 men with widely varying mass-specific surface areas (range, 232.3-292.7 cm(2)/kg), but of similar age, aerobic fitness, and adiposity. Subjects completed two trials under compensable conditions (28.1°C, 36.8% relative humidity), each involving rest (20 min) and steady-state cycling (45 min) at two matched metabolic heat-production rates (light, ∼135 W/m(2); moderate, ∼200 W/m(2)). Following equivalent mean body temperature changes, forearm blood flow and vascular conductance (r = 0.63 and r = 0.65) shared significant, positive associations with the mass-specific surface area during light work (P < 0.05), explaining ∼45% of the vasomotor variation. Conversely, during light and moderate work, whole body sweat rate, as well as local sweat rate and sudomotor sensitivity at three of four measured sites, revealed moderate, negative relationships with the mass-specific surface area (correlation coefficient range -0.37 to -0.73, P < 0.05). Moreover, those relationships could uniquely account for between 10 and 53% of those sweating responses (P < 0.05). Therefore, both thermoeffector responses displayed a significant morphological dependency in the presence of equivalent thermoafferent drive. Indeed, up to half of the interindividual variation in these effector responses could now be explained through morphological differences and the first principles governing heat transfer. PMID:27125845

  7. Massegravene på Tell Brak

    DEFF Research Database (Denmark)

    Skuldbøl, Tim Boaz Bruun; Hald, Mette Marie

    2010-01-01

    Helt nye udgravninger af massegrave i Syrien har afsløret overraskende nyt fra oldtidens Mesopotamien. Massegravene er 6000 år gamle og stammer fra en af verdens tidligste byer, oldtidsbyen Nagar, hvis navn i dag er Tell Brak. De hundredvis af lig, som er fundet i massegravene, er begravet sammen...

  8. Telling Stories: Past and Present Heroes

    Science.gov (United States)

    Smith, Colin Bridges

    2007-01-01

    Among the Xhosa tribe in South Africa storytelling is a magnificent art. But these stories are more than mere entertainment. Xhosa scholar Harold Scheub says story-telling for the Xhosa people is "not only a primary means of entertainment and artistic expression in the society, it is also the major educational device." Beyond education, the…

  9. Journalism Curiosity and Story Telling Frame

    DEFF Research Database (Denmark)

    Grunwald, Ebbe; Rupar, Verica

    2009-01-01

    This comparative study of journalism practices in Australia and Denmark explores the interplay between two concepts relevant for journalism's meaning-making activity: a curiosity seen as an action meant to close an information gap, and a story telling frame seen as a form of structuring information...

  10. [3H]Methotrexate loss from the rat brain following enhanced uptake by osmotic opening of the blood-brain barrier

    International Nuclear Information System (INIS)

    Right brain regions of anesthetized rats were loaded with [3,5,7-3H]methotrexate ([3H]MTX) or with [14C]sucrose by infusing the tracers into the right carotid artery, after the blood-brain barrier had been opened by right carotid infusion of a hypertonic arabinose solution. During the 6 hr following the procedure, the [3H]MTX concentration in 7 right-sided brain regions, when normalized to the plasma concentration integral during tracer infusion, fell, with an average half-time of 4.8 hr as compared to less than 20 min for the initial rate of loss [14C]sucrose. Right-left brain concentration differences 3 hr after treatment were statistically significant (p less than 0.05) for [3H]MTX but not for [14C]sucrose. The results indicate that intracerebral [3H]MTX is lost more slowly than is intracerebral [14C]sucrose, possibly because [3H]MTX enters brain cells, whereas [14C]sucrose remains largely extracellular

  11. Autologous blood donation

    OpenAIRE

    Goodnough, Lawrence T

    2004-01-01

    Although preoperative autologous blood donation is employed in elective surgery, this is declining because of the increasingly safe allogeneic blood supply. However, it continues to be used because of the public's perception of allogeneic blood risks and increasing blood shortages. Patients may donate a unit of blood (450 ± 45 ml) as often as twice weekly, up to 72 hours before surgery. Preoperative autologous blood is most beneficial in procedures that cause significant blood loss. It has be...

  12. Transplantation of human umbilical cord blood-derived mesenchymal stem cells or their conditioned medium prevents bone loss in ovariectomized nude mice.

    Science.gov (United States)

    An, Jee Hyun; Park, Hyojung; Song, Jung Ah; Ki, Kyung Ho; Yang, Jae-Yeon; Choi, Hyung Jin; Cho, Sun Wook; Kim, Sang Wan; Kim, Seong Yeon; Yoo, Jeong Joon; Baek, Wook-Young; Kim, Jung-Eun; Choi, Soo Jin; Oh, Wonil; Shin, Chan Soo

    2013-03-01

    Umbilical cord blood (UCB) has recently been recognized as a new source of mesenchymal stem cells (MSCs) for use in stem cell therapy. We studied the effects of systemic injection of human UCB-MSCs and their conditioned medium (CM) on ovariectomy (OVX)-induced bone loss in nude mice. Ten-week-old female nude mice were divided into six groups: Sham-operated mice treated with vehicle (Sham-Vehicle), OVX mice subjected to UCB-MSCs (OVX-MSC), or human dermal fibroblast (OVX-DFB) transplantation, OVX mice treated with UCB-MSC CM (OVX-CM), zoledronate (OVX-Zol), or vehicle (OVX-Vehicle). Although the OVX-Vehicle group exhibited significantly less bone mineral density (BMD) gain compared with the Sham-Vehicle group, transplantation of hUCB-MSCs (OVX-MSC group) has effectively prevented OVX-induced bone mass attenuation. Notably, the OVX-CM group also showed BMD preservation comparable to the OVX-MSC group. In addition, microcomputed tomography analysis demonstrated improved trabecular parameters in both the OVX-MSC and OVX-CM groups compared to the OVX-Vehicle or OVX-DFB group. Histomorphometric analysis showed increased bone formation parameters, accompanied by increased serum procollagen type-I N-telopeptide levels in OVX-MSC and OVX-CM mice. However, cell-trafficking analysis failed to demonstrate engraftment of MSCs in bone tissue 48 h after cell infusion. In vitro, hUCB-MSC CM increased alkaline phosphatase (ALP) activity in human bone marrow-derived MSCs and mRNA expression of collagen type 1, Runx2, osterix, and ALP in C3H10T1/2 cells. Furthermore, hUCB-MSC CM significantly increased survival of osteocyte-like MLO-Y4 cells, while it inhibited osteoclastic differentiation. To summarize, transplantation of hUCB-MSCs could effectively prevent OVX-mediated bone loss in nude mice, which appears to be mediated by a paracrine mechanism rather than direct engraftment of the MSCs. PMID:23215868

  13. Effect of water and feed withdrawal and health status on blood and serum components, body weight loss, and meat and carcass characteristics of Holstein slaughter cows.

    Science.gov (United States)

    Vogel, K D; Claus, J R; Grandin, T; Oetzel, G R; Schaefer, D M

    2011-02-01

    During marketing, cattle may be exposed to periods of water deprivation. The impact of water and feed access and health status on the physiological well-being and carcass characteristics of Holstein slaughter cows during preslaughter marketing was studied through analysis of serum components, BW loss percentage, and fresh meat composition. Ninety-one multiparous Holstein cows (609 ± 89 kg mean BW, 2.9 ± 0.5 mean BCS, varying stage of lactation) were purchased over 3 wk in 3 groups (n = 31, 29, and 31) at a terminal market in central Wisconsin. Each cow was screened to determine health status (sick or not sick) and randomly assigned to 1 of 3 water and feed withdrawal treatment pens (AL, ad libitum access to water for 36 h; 18H, 18 h of ad libitum access to water followed by 18 h of water withdrawal; 36H, 36 h of water withdrawal; all 3 treatments included 36 h of feed withdrawal) in a randomized complete block arrangement with repeated measures for serum components. Blood samples were collected by tail venipuncture at 0, 9, 18, 27, and 36 h of each treatment. Ambient temperatures were 1.9 ± 6.2°C during the trial period, which occurred over a 3-wk period in March and April 2007 near Arlington, WI. No difference (P > 0.05) was observed in mean serum cortisol in AL (18.41 ± 2.17 ng/mL) or 36H (22.98 ± 2.17 ng/mL). Mean serum glucose was greater (P water and feed access treatment. Based on these results, water and feed withdrawal in lairage should not exceed 18 h during the marketing of Holstein slaughter cows acclimated to springtime conditions to maintain BW, serum component concentrations, and fresh meat composition.

  14. Stroma-contact prevents loss of hematopoietic stem cell quality during ex vivo expansion of CD34+ mobilized peripheral blood stem cells.

    Science.gov (United States)

    Breems, D A; Blokland, E A; Siebel, K E; Mayen, A E; Engels, L J; Ploemacher, R E

    1998-01-01

    Stroma-supported long-term cultures (LTC) allow estimation of stem cell quality by simultaneous enumeration of hematopoietic stem cell (HSC) frequencies in a graft using the cobblestone area forming cell (CAFC) assay, and the ability of the graft to generate progenitors in flask LTC (LTC-CFC). We have recently observed that the number and quality of mobilized peripheral blood stem cells (PBSC) was low in patients having received multiple rounds of chemotherapy. Moreover, grafts with low numbers of HSC and poor HSC quality had a high probability to cause graft failure upon their autologous infusion. Because ex vivo culture of stem cells has been suggested to present an attractive tool to improve hematological recovery or reduce graft size, we have studied the possibility that such propagation may affect stem cell quality. In order to do so, we have assessed the recovery of different stem cell subsets in CD34+ PBSC after a 7-day serum-free liquid culture using CAFC and LTC-CFC assays. A numerical expansion of stem cell subsets was observed in the presence of interleukin-3 (IL-3), stem cell factor, and IL-6, while stroma-contact, stromal soluble factors, or combined addition of FLT3-ligand and thrombopoietin improved this parameter. In contrast, ex vivo culture severely reduced the ability of the graft to produce progenitors in LTC while stromal soluble factors partly abrogated this quality loss. The best conservation of graft quality was observed when the PBSC were cultured in stroma-contact. These data suggest that ex vivo propagation of PBSC may allow numerical expansion of various stem cell subsets, however, at the expense of their quality. In addition, cytokine-driven PBSC cultures require stroma for optimal maintenance of graft quality. PMID:9414274

  15. 肠系膜淋巴管结扎对急性失血大鼠血液凝固性的影响%Effect of mesenteric lymph duct ligation on coagulability of blood after acute loss of blood in rats

    Institute of Scientific and Technical Information of China (English)

    赵自刚; 刘春艳; 张玉平; 张静; 赵永泉; 牛春雨

    2009-01-01

    Objective To observe the effects of mesenteric lymph duct ligation on platelet function, thrombus formation in vitro and coagulation function in rats with acute loss of blood, and investigate the role of intestinal lymphatic pathway on coagulability change during acute loss of blood. Methods Twenty male Wistar rats were randomly divided into loss of blood group (n=10) and ligation group (n=10). The acute loss of blood model was reproduced by withdrawing blood (one fourth of body whole blood volume) with an automatic withdrawal-infusion machine through right common carotid artery. In ligation group, the mesenteric lymph duct was ligated after loss of blood, and in loss of blood group only a thread was passed under the mesenteric lymph duct. The rats′ survival rate at 24 hours was recorded. After 24 hours, surviving rats were anesthetized again, and 6 ml of blood was withdrew from left common carotid artery rapidly. The platelet adhesive rate, platelet aggregation rate, thrombus formation in vitro, coagulation function were determined before and after experiment, and the cerebral blood flow was measured. Results There were 6 rats alive in loss of blood group (60%), and 9 rats alive in ligation group (90%). The platelet adhesive rate, platelet aggregation rate, fibrinogen (Fib) content were increased in both groups, and cerebral blood flow was lower compared with before experiment significantly. The activated partial thromboplastin time (APTT) in loss of blood group, and thrombin time (TT) in both groups were prolonged. And the length of wet thrombus, wet weight of thrombus, length of dry thrombus, dry weight of thrombus and thrombus formation rate in loss of blood group were significantly increased compared with before experiment (P0.05).与实验前相比,两组血小板黏附率、血小板聚集率、纤维蛋白原(Fib)均显著升高,凝血酶时间(TT)显著延长,脑血流量显著降低;失血组活化部分凝血活酶时间(APTT)显著延长,

  16. [Truth telling of Alzheimer's disease diagnosis].

    Science.gov (United States)

    Fuentes R, Paola; Prato, Juan Andrés

    2012-06-01

    Alzheimer's disease is becoming an increasingly common problem due to population aging. Most of the research on truth telling in relation to diagnosis has been done in oncology. However, although growing, there has a lack of interest about attitudes held among physicians towards disclosing the diagnosis of Alzheimer's disease. Physicians, family caregivers and patients have different views about it. The reasons most often given for communicating the diagnosis are the right to know, relief of anxiety to know the cause of memory problems, early access to treatment and ability to plan ahead. On the contrary, the reasons for concealing the diagnosis are based on the right not to know, the anxiety associated to knowing the diagnosis and the absence of curative therapies for the disease. The aim of this paper is to report the current state of literature on diagnostic truth telling in dementia, review the ethical principles involved, and finally give a strategy to address the issue.

  17. Member State Event: Telling CERN's story !

    CERN Multimedia

    2004-01-01

    As part of the events to mark the Laboratory's fiftieth anniversary, members of the CERN personnel are telling the story of CERN. Robert Cailliau (on the right), currently responsible for CERN's external communications, and Chiara Mariotti (in the center), a physicist working at CMS, were invited to talk about the history of CERN and the Web at a conference in the 'Science Thursdays' series entitled 'From the Quark to the Web' in Turin on 26 February.

  18. Telling time in the absence of clocks.

    OpenAIRE

    Uma R. Karmarkar; Buonomano, Dean V.

    2007-01-01

    Decisions based on the timing of sensory events are fundamental to sensory processing. However, the mechanisms by which the brain measures time over ranges of milliseconds to seconds remain unknown. The dominant model of temporal processing proposes that an oscillator emits events that are integrated to provide a linear metric of time. We examine an alternate model in which cortical networks are inherently able to tell time as a result of time-dependent changes in network state. Using compute...

  19. What I Tell My Graduate Students

    Science.gov (United States)

    Davis, Lennard J.

    2011-01-01

    This author realizes that an important part of his job is to make sure his graduate students get their own jobs. What that means is talking about job placement as soon as they walk in the door and tell him they want to do a Ph.D. First he informs them of the current job situation, whatever that is at the time. He makes it clear that the first…

  20. Use of an ex-vivo porcine kidney model to compare the blood loss of different size of nephrostomy tracts%经皮肾镜术大小通道出血量的比较

    Institute of Scientific and Technical Information of China (English)

    雷华; 王德娟; 罗建斌; 邱剑光

    2011-01-01

    目的 比较经皮肾镜术大小通道出血量.方法 采用离体的生理盐水持续灌注的猪肾脏模型.在猪肾上建立穿刺通道后,先后建立16、18、22、24、30F5组通道,每组10个通道,分别测量失血量.结果 5组通道的出血量分别为(5.84±0.98)、(5.99±0.85)、(9.76±1.05)、(11.90±1.49)、(14.48±1.30) g/min,通道越大,出血量越多,差异有统计学意义(P<0.05).16 F与18F通道出血量之间比较差异无统计学意义(P>0.05).结论 在经皮肾镜手术中,通道越大,出血量越多,小通道经皮肾镜术可减少术中出血量.%Objective To compare the blood loss of different size of nephrostomy tracts in percutaneous nephrolithotomy (PCNL).Methods The model of isolated normal saline ( NS)-perfused porcine kidney was used to determine the blood loss of different size of nephrostomy tracts.By applying the technique of percutaneous nephrostomy,five groups of different size of nephrostomy tracts ( 16,18,22,24,30 F) were established on the porcine kidney gradually,with 10 tracts in every group,then the blood loss of each group was measured respectively.Results The blood loss of the five tracts ( 16,18,22,24,30 F)was (5.84±0.98),(5.99±0.85),(9.76±1.05),(11.90±1.49),(14.48±1.30) g/min,respectively.The blood loss was increased with the size of the tract diameter ( P < 0.05 ).There was no significant difference between 16 F and 18 F groups ( P > 0.05 ).Conclusion The blood loss of PCNL was increased with the size of the nephrostomy tracts.Mini-PCNL could cause less bleeding than standard-PCNL.

  1. Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Genes in the Peripheral Blood of Late Postmenopausal Osteoporotic Women

    OpenAIRE

    Tchetina, Elena V.; Karina A. Maslova; Mikhail Y. Krylov; Myakotkin, Valery A.

    2015-01-01

    We aimed to identify bone related markers in the peripheral blood of osteoporotic (OP) patients that pointed toward molecular mechanisms underlying late postmenopausal bone loss. Whole blood from 22 late postmenopausal OP patients and 26 healthy subjects was examined. Bone mineral density (BMD) was measured by DXA. Protein levels of p70-S6K, p21, MMP-9, TGFβ1, and caspase-3 were quantified by ELISA. Gene expression was measured using real-time RT-PCR. OP registered by low BMD indices in late ...

  2. THE YARMOUKIAN POTTERY ASSEMBLAGE OF TELL ABU SUWWAN, JORDAN

    OpenAIRE

    Al Nahar, Maysoon; Kafafi, Zeidan

    2015-01-01

    The archaeological excavations conducted at the site Tell Abu Suwwan indicated that it was continuously occupied during two main periods from the Middle Pre-Pottery Neolithic B through the Pottery Neolithic (Yarmoukian). The main focus of this paper is to study the pottery assemblage encountered in the Yarmoukian strata at Abu Tell Suwwan. Excavations at Tell Abu Suwwan in 2005 - 2008 yielded a total of 488 pieces of Yarmoukian pottery. The sample under study includes 86 Yarmoukian pottery sh...

  3. 氨甲环酸对全髋关节置换术隐性失血的影响%Effect of tranexamic acid on the hidden blood loss after total hip arthroplasty

    Institute of Scientific and Technical Information of China (English)

    傅峥; 张健; 姚海

    2012-01-01

    Objective: To assess the impact of tranexamic acid on the hidden blood loss after unilateral total hip arthroplasty. Methods: Totally 40 patients who received unilateral total hip arthroplasty due to femoral neck fracture were randomly divided into two groups. Group A included 20 cases without tranexamic acid,in which the patients were just given 250 ml normal saline when the surgery star-tod ; Group B included 20 cases with tranexamic acid, and the patients in this group were given 20 mg/kg tranexamic acid with 250 ml normal saline when the surgery started. The total red blood cell loss,visible red blood cell loss and hidden red blood cell loss of the two groups were measured and the comparative analysis was conducted. Results: Results of the visible red blood losses in group A and group B were (95.43 ±17.72)ml and (48.84 ± 15.04)ml,respectively; the hidden red blood loss in group A and group B were (322.37 ± 57.69) ml and (169. 89 ±58.50) ml,respectively. The visible and hidden red blood cell losses in group B were both significantly less than those in group A(P<0.05). Conclusion:Tranexamic acid reduces both the visible and hidden red blood loss after the unilateral total hip arthroplasty.%目的:探讨氨甲环酸对单侧全髋关节置换术隐性失血的影响.方法:40例因单侧股骨颈骨折行全髋关节置换术患者随机分为2组.A组20例,不使用氨甲环酸,手术开始时予250 ml生理盐水静滴;B组20例,使用氨甲环酸,手术开始时将氨甲环酸按20 mg/kg稀释于250 ml生理盐水中静滴.分别计算其显性及隐性红细胞丢失量,并进行相应对比分析.结果:A组与B组显性红细胞丢失量分别为(95.43 ±17.72) ml和(48.84±15.04) ml(P<0.05);A组与B组隐性红细胞丢失量分别为(322.37 ±57.69) ml和(169.89±58.50) ml(P<0.05).结论:氨甲环酸能明显减少单侧全髋关节置换术的显性及隐性失血.

  4. A randomised controlled trial of oxytocin 5IU and placebo infusion versus oxytocin 5IU and 30IU infusion for the control of blood loss at elective caesarean section--pilot study. ISRCTN 40302163.

    LENUS (Irish Health Repository)

    Murphy, Deirdre J

    2012-02-01

    OBJECTIVE: To compare the blood loss at elective lower segment caesarean section with administration of oxytocin 5IU bolus versus oxytocin 5IU bolus and oxytocin 30IU infusion and to establish whether a large multi-centre trial is feasible. STUDY DESIGN: Women booked for an elective caesarean section were recruited to a pilot randomised controlled trial and randomised to either oxytocin 5IU bolus and placebo infusion or oxytocin 5IU bolus and oxytocin 30IU infusion. We wished to establish whether the study design was feasible and acceptable and to establish sample size estimates for a definitive multi-centre trial. The outcome measures were total estimated blood loss at caesarean section and in the immediate postpartum period and the need for an additional uterotonic agent. RESULTS: A total of 115 women were randomised and 110 were suitable for analysis (5 protocol violations). Despite strict exclusion criteria 84% of the target population were considered eligible for study participation and of those approached only 15% declined to participate and 11% delivered prior to the planned date. The total mean estimated blood loss was lower in the oxytocin infusion arm compared to placebo (567 ml versus 624 ml) and fewer women had a major haemorrhage (>1000 ml, 14% versus 17%) or required an additional uterotonic agent (5% versus 11%). A sample size of 1500 in each arm would be required to demonstrate a 3% absolute reduction in major haemorrhage (from baseline 10%) with >80% power. CONCLUSION: An additional oxytocin infusion at elective caesarean section may reduce blood loss and warrants evaluation in a large multi-centre trial.

  5. Children's Reasoning about Lie-Telling and Truth-Telling in Politeness Contexts

    Science.gov (United States)

    Heyman, Gail D.; Sweet, Monica A.; Lee, Kang

    2009-01-01

    Children's reasoning about lying and truth-telling was examined among participants ages 7-11 (total N = 181) with reference to conflicts between being honest and protecting the feelings of others. In Study 1, participants showed different patterns of evaluation and motivational inference in politeness contexts vs. transgression contexts: in…

  6. Story Telling or Storied Telling? Media's Pedagogical Ability to Shape Narrative as a Form of "Knowing"

    Science.gov (United States)

    Blevins, Dean G.

    2007-01-01

    Storytellers know that stories are "formed" in their telling. Stories, whether oral or written, personal or mass communicated, ultimately express the boundaries of their medium (their "embodiment" through mediated forms). Religious Educators must always address the medium as well as the message in any theory of narrative accounting. Media often…

  7. 氨甲环酸对单侧全膝关节置换失血量的影响及安全性评价%Efficacy and safety of tranexamic acid on blood loss after unilateral total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    闵鹏; 彭银虓; 胡江海; 顾祖超

    2015-01-01

    背景:全膝关节置换围手术期出血较多,而输血不仅额外增加费用,延长康复时间,也存在免疫反应和传染疾病的风险.因此,减少全膝关节置换失血量显得十分重要.目的:评估氨甲环酸在全膝关节置换中止血的有效性和安全性.方法:将 64 例因骨关节病拟行单侧全膝关节置换的患者随机分为两组,每组 32 例.氨甲环酸组于置换前 15 min将氨甲环酸按10 mg/kg稀释于250 mL等渗盐水中静脉滴注;对照组同时间点给予等量生理盐水.对比术中失血量、置换后可见失血量、置换后血红蛋白减少量、输血量、输血人数和置换后纤维蛋白原、凝血酶原时间等凝血评价指标.观察置换后下肢深静脉栓塞的症状,并在置换后30 d行下肢血管多普勒检查.结果与结论:两组术中出血量差异无显著性意义(P>0.05),氨甲环酸组置换后可见失血量低于对照组(P<0.001),氨甲环酸组的输血量和输血人数同样低于对照组(P<0.001);置换后血红蛋白值氨甲环酸组明显高于对照组(P<0.001).置换后3 h两组的凝血指标差异无显著性意义;但两组D-二聚体均明显高于置换前,氨甲环酸组低于对照组,差异有显著性意义(P<0.001).两组患者置换后均未发现下肢深静脉血栓形成.提示氨甲环酸能够有效减少全膝关节置换后的失血量、降低输血率和输血量,且不增加置换后深静脉血栓形成的风险.%BACKGROUND:Total knee arthroplasty is always associated with peripheral blood loss.Blood transfusion not only involves additional cost and prolongs rehabilitation time,but also carries substantial risk of immunologic reaction and disease transmission.Therefore it is very important to reduce blood loss of total knee arthroplasty.OBJECTIVE:To investigate the efficacy and safety of tranexamic acid on reducing blood loss after total knee arthroplasty.METHODS:We enroled 64 patients with primary osteoarthritis

  8. Tell me! The right of the child to information

    NARCIS (Netherlands)

    A.M.Th.L. Koren

    1996-01-01

    Tell me! considers the child as a seeker, an information seeker, and researches the role information plays in the child's developmental process. Information on how to become a full-grown human being is essential. Which sources are important to the child? Tell me! examines the extent to which these i

  9. Telling Data Stories: Essential Dialogues for Comparative Reasoning

    Science.gov (United States)

    Pfannkuch, Maxine; Regan, Matt; Wild, Chris; Horton, Nicholas J.

    2010-01-01

    Language and the telling of data stories have fundamental roles in advancing the GAISE agenda of shifting the emphasis in statistics education from the operation of sets of procedures towards conceptual understanding and communication. In this paper we discuss some of the major issues surrounding story telling in statistics, challenge current…

  10. Analysis on related factors of amount of blood loss during delivery in pregnant women combined with hysteromyoma%妊娠合并子宫肌瘤分娩出血量的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    张慧敏; 张丽丽

    2012-01-01

    目的:探讨影响妊娠合并子宫肌瘤孕妇分娩出血量的相关因素.方法:2007~2011年在产前检查时发现子宫肌瘤且至少有1个直径≥5 cm肌瘤的孕妇192例,分析产妇的年龄、产次、分娩方式、新生儿体重及肌瘤的数量、单发肌瘤的最大径线、多发肌瘤最大径线之和、肌瘤的位置与分娩出血量的关系.结果:孕妇的年龄及肌瘤的数量与出血量呈正相关,而分娩方式、新生儿体重及肌瘤的大小和位置与出血量无显著相关性.结论:高龄和多发性子宫肌瘤是妊娠合并子宫肌瘤孕妇分娩出血量多的重要因素,必须提前做好产前准备,备足充足的血源,以避免严重产后出血导致产妇死亡.%Objective: To explore the related influencing factors of amount of blood loss during delivery in pregnant women combined with hysteromyoma. Methods; A total of 192 pregnant women were found with hysteromyoma and at least the diameter of one myoma ^ 5 cm during prenatal examination from 2007 to 2011; the relationship between maternal age, parity, delivery modes, neonatal weight, the number of myoma, the longest diameter of single myoma, the sum of longest diameters of multiple myoma, the location of myoma and the a-mount of blood loss during delivery was analyzed. Results; There was a positive correlation between maternal age, the number of myoma and the amount of blood loss; delivery modes, neonatal weight, the size and location of myoma were not correlated with the amount of blood loss during delivery. Conclusion; Advanced age and multiple hysteromyoma were important factors inducing excessive hemorrhage during delivery in pregnant women combined with hysteromyoma, prenatal preparation should be conducted and sufficient blood resource should be prepared to avoid maternal death induced by serious postpartum hemorrhage.

  11. "The Tramp", a blood donation propagandist?

    Science.gov (United States)

    Lefrère, J-J; Garraud, O

    2016-02-01

    The French pioneer for blood transfusion, who eventually organized the very early blood transfusion centers worldwide, went to imagine a scenario written in purpose for Charlie Chaplin, the unique character of "The Tramp" ("Charlot" in French). The movie Star was offered to feature a blood donation propagandist, and no longer the perpetual, well-known, "loser". This anecdote, besides being amusing, tells a lot on how Arnault Tzank encompassed all the difficulties in collecting blood enough to meet the demand, at all times; his proposal turns out to be extremely modern and questions nowadays marketing for blood donation. PMID:26778105

  12. Academic Training: Telling the truth with statistics

    CERN Multimedia

    Françoise Benz

    2005-01-01

    2004-2005 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 21, 22, 23, 24 & 25 February from 11.00 to 12.00 hrs - Main Auditorium, bldg. 500 Telling the truth with statistics by G. D'Agostini / NFN, Roma, Italy The issue of evaluating and expressing the uncertainty in measurements, as well as that of testing hypotheses, is reviewed, with particular emphasis on the frontier cases typical of particle physics experiments. Fundamental aspects of probability will be addressed and the applications, solely based on probability theory, will cover several topics of practical interest, including counting experiments, upper/lower bounds, systematic errors, fits and comparison of hypotheses. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch

  13. Telling business stories as fellowship-tales

    DEFF Research Database (Denmark)

    Smith, Robert; Neergaard, Helle

    2015-01-01

    Purpose – This paper aims to explore the “Fellowship-Tale” as an alternative tale type for narrating entrepreneur stories. The authors illustrate this by telling the Pilgrim business story. It is common for the deeds of men who founded businesses to be narrated as heroic entrepreneur stories....... Such fairy tales are dominant narratives in Western culture but do not resonate with everyone, particularly women. Consequentially, many businesswomen do not engage in the rhetoric of enterprise. Design/methodology/approach – The qualitative, analytic approaches adopted in this study include narratology...... – The research indicates that “fellowship-tales” provide a viable and credible alternative to the fairy-tale rendition common in entrepreneur and business stories. Research limitations/implications – An obvious limitation is that one merely swaps one narrative framework for another, albeit it offers dissenting...

  14. Tell Me More: Issues and Challenges

    Directory of Open Access Journals (Sweden)

    Harwati Hashim

    2012-07-01

    Full Text Available Integration of technology into language education has become an everyday occurrence. Educational multimedia courseware as resource materials to enhance the teaching and learning of English language was produced extensively. Regardless of the cost, computers and courseware are becoming important tools for learning in institutions. Therefore, a considerable pressure is being put on the ESL teachers to make use of the courseware marvels in their lesson since the cost of the courseware is rather expensive. This paper aims to investigate the issues and challenges faced by the ESL lecturers on the use of a courseware named TELL ME MORE in a polytechnic in Melaka. Data was collected via semi-structured interviews with four ESL lecturers at the polytechnic. Findings show that the courseware is a useful tool for language learning. However, there are certain challenges that the ESL lecturers had to face such as time and lack of facilities.

  15. Telling the truth and medical ethics.

    Science.gov (United States)

    Gillon, R

    1985-11-30

    Gillon discusses the conflicting moral implications of the principles of respect for autonomy and of beneficence and non-maleficence when telling patients the truth about their illnesses and treatments. The case for nondisclosure is usually based on three major arguments: that doctors' Hippocratic obligations to benefit and not harm their patients take precedence over not deceiving them; that the range of possible conditions and prognoses makes it difficult for physicians to know the full truth or for patients to comprehend it; and that patients do not wish to be told dire news. Gillon rejects each of these arguments, contending that avoiding deceit is a basic moral norm that can be defended from utilitarian as well as deontological points of view. With regard to the argument concerning patient attitudes, he recommends that pilot studies be done, asking patients what their preferences are at the time they register with a doctor or hospital.

  16. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / ... heavier and older, what does recent research on cholesterol and heart health tell us that Americans need ...

  17. Relationship of tranexamic acid therapy duration with hidden blood loss after total hip arthroplasty%氨甲环酸使用时间与全髋关节置换术隐性失血的临床研究

    Institute of Scientific and Technical Information of China (English)

    傅峥; 张健

    2013-01-01

    Objective To assess the impact of tranexamic acid on visible and hidden blood loss after the preliminary unilateral total hip arthtoplasty (THA).Methods The study involved 60 patients who received primary unilateral THA due to femoral neck fracture from March 2010 to September 2011.They were 18 males and 42 females,at 58 to 86 years of age (average 74.5 years).They were divided into Group A (n =20),not given tranexamic acid,Group B (n =20),given tranexamic acid in operation,Group C (n =20),given tranexamic acid at preoperative one hour according to stratified random method.Total red blood cell loss,visible red blood cell loss,and hidden red blood cell loss in each group were calculated.Results Visible red blood cell loss in Groups A,B,and C was (95.4 ± 17.7) ml,(45.5 ± 11.5) rnl,and (45.3 ± 8.4) ml respectively.Moreover,difference of visible red blood cell loss was significant between Groups A and B (P < 0.05),but insignificant between Groups B and C (P > 0.05).Hidden red blood cell loss in Groups A,B,and C was (322.4 ± 57.7) ml,(203.8 ±46.6) ml,and (137.6 ± 34.7) ml respectively,with significant difference between Groups A and B (P<0.05) and between Groups B and C (P<0.05).Conclusions Tranexamic acid reduces the visible and hidden blood loss in primary unilateral THA significantly.While tranexamic acid administered at preoperative one hour gains advantage of less hidden blood loss over the intraoperative administration.%目的 探讨氨甲环酸对初次单侧全髋关节置换术(total hip arthroplasty,THA)显性及隐性失血的影响. 方法 选取2010年3月-2011年9月行初次单侧THA患者60例,其中男18例,女42例;年龄58 ~86岁,平均74.5岁,诊断均为股骨颈骨折.按分层随机分组法分为:A组(20例,不使用氨甲环酸)、B组(20例,术中使用氨甲环酸)和C组(20例,术前1h使用氨甲环酸).计算总红细胞丢失量、显性红细胞丢失量及隐性红细胞丢失量. 结果 A、B、C组显性

  18. La ceramica dei livelli Uruk di Tell Hassan, Hamrin

    OpenAIRE

    Nannucci, Simone

    2012-01-01

    International audience Tell Hassan is one of the few sites in the Hamrin basin region in Iraq that hasshown remains of an Uruk period settlement along with Tell Rubeidheh and Tell al-Ahmad Hattu. The site was excavated by the archaeological mission of the Centro Ricerche Archeologiche e Scavi di Torino per il Medio Oriente e l’Asia in the late ‘70s. The investigations have unearthed at least three different Uruk levels but only the two most recent ones have been investigated on a limited s...

  19. Blood Clots

    Science.gov (United States)

    ... Index A-Z Blood Clots Blood clots are semi-solid masses of blood that can be stationary (thrombosis) ... treated? What are blood clots? Blood clots are semi-solid masses of blood. Normally, blood flows freely through ...

  20. Loss of bone marrow adrenergic beta 1 and 2 receptors modifies transcriptional networks, reduces circulating inflammatory factors, and regulates blood pressure.

    Science.gov (United States)

    Ahmari, Niousha; Schmidt, Jordan T; Krane, Gregory A; Malphurs, Wendi; Cunningham, Bruce E; Owen, Jennifer L; Martyniuk, Christopher J; Zubcevic, Jasenka

    2016-07-01

    Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there appears to be a direct role for inflammatory bone marrow (BM) cells in the pathophysiology of hypertension. However, the molecular and neural mechanisms underlying this interaction have not been characterized. Here, we transplanted whole BM cells from the beta 1 and 2 adrenergic receptor (AdrB1(tm1Bkk)AdrB2(tm1Bkk)/J) knockout (KO) mice into near lethally irradiated C57BL/6J mice to generate a BM AdrB1.B2 KO chimera. This allowed us to evaluate the role of the BM beta 1 and beta 2 adrenergic receptors in mediating BM IS homeostasis and regulating blood pressure (BP) in an otherwise intact physiological setting. Fluorescence-activated cell sorting demonstrated that a decrease in systolic and mean BP in the AdrB1.B2 KO chimera is associated with a decrease in circulating inflammatory T cells, macrophage/monocytes, and neutrophils. Transcriptomics in the BM identified 7,419 differentially expressed transcripts between the C57 and AdrB1.B2 KO chimera. Pathway analysis revealed differentially expressed transcripts related to several cell processes in the BM of C57 compared with AdrB1.B2 KO chimera, including processes related to immunity (e.g., T-cell activation, T-cell recruitment, cytokine production, leukocyte migration and function), the cardiovascular system (e.g., blood vessel development, peripheral nerve blood flow), and the brain (e.g., central nervous system development, neurite development) among others. This study generates new insight into the molecular events that underlie the interaction between the sympathetic drive and IS in modulation of BP. PMID:27235450

  1. Freud's Psychoanalysis of The Tell-Tale Heart

    Institute of Scientific and Technical Information of China (English)

    杜红云; 梁静

    2014-01-01

    Edgar Allan Poe is a famous American poet, short fiction writer and critic. He is good at writing horror tale and detective story. Many of his short stories show the narrator's abnormal mind. The Tell-Tale Heart is one of his famous short stories. This paper will analyze Poe's The Tell-Tale Heart by using Freud's psychoanalysis theory:the three-level personality.

  2. Freud’s Psychoanalysis of The Tell-Tale Heart

    Institute of Scientific and Technical Information of China (English)

    杜红云; 梁静

    2014-01-01

    Edgar Allan Poe is a famous American poet,shor fiction writer and critic.He is good at writing horror tale and detective story.Many of his short stories show the narrator’s abnormal mind.The Tell-Tale Heart is one of his famous shor stories.This paper will analyze Poe’s The Tell-Tale Heart by using Freud’s psychoanalysis theory:the three-level personality.

  3. Children's drawing and telling of sustainability in the home

    OpenAIRE

    Desjardins, Audrey; Wakkary, Ron

    2011-01-01

    This paper describes a pilot study about children’s perspective on environmental sustainability in the home through the drawing-telling technique. We utilize the drawing-telling technique as described by Susan Wright [6] for interviewing children about issues related to sustainability. The participants (children from age 10 to 13) were asked to draw two houses (current and ideal) and then describe their drawings in terms of sustainable actions and features. This pilot study is an initial step...

  4. The Tell el-Maskhûta Hoards (1905)

    DEFF Research Database (Denmark)

    Christiansen, Erik

    2007-01-01

    Based on Milne's handwritten lists, the author offers the first actual publication of the five hoards of Alexandrian billon coins, which Currelly and Frost bought in Tell el-Maskhûta in 1905.......Based on Milne's handwritten lists, the author offers the first actual publication of the five hoards of Alexandrian billon coins, which Currelly and Frost bought in Tell el-Maskhûta in 1905....

  5. 静脉输注氨甲环酸对全膝关节置换后隐性失血的影响%Effect of intravenous tranexamic acid on hidden blood loss in total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    赵旻暐; 李子剑; 张克; 曾琳; 方拓

    2015-01-01

    背景:人工全膝关节置换过程中,止血带的使用、手术创伤等因素会导致纤溶系统的异常激活,是术后失血的主要原因。氨甲环酸是一类抗纤溶药物,在人工全膝关节置换中使用,可减少置换后显性失血、总失血量,并降低异体血输血率。然而,氨甲环酸对人工全膝关节置换后隐性失血的影响尚未明确。目的:观察静脉输注氨甲环酸对初次全膝关节置换后隐性失血的影响。方法:回顾性分析2013年6至12月北京大学第三医院行初次单侧全膝关节置换54例患者的临床资料,按照是否使用氨甲环酸分为两组。氨甲环酸组22例在术中经静脉给予总量2 g的氨甲环酸,对照组32例使用等量生理盐水。两组患者置换后均口服利伐沙班抗凝。记录患者置换前及置换后连续5 d的血红蛋白、血红细胞压积,采用Gross方程计算总失血量和隐性失血量,比较两组间失血量的差异性。置换后1周行下肢静脉超声检查,判断有无下肢深静脉血栓形成。结果与结论:两组患者一般资料、围术期情况等比较差异均无显著性意义(P >0.05)。氨甲环酸组患者置换后引流量、显性失血量、总失血量、自体血回输量、异体血输注量均明显少于对照组,差异有显著性意义(P 0.05). Postoperative drainage, dominant blood loss, total blood volume, the amount of autologous blood transfusion and the amount of alogeneic blood transfusion were significantly less in the tranexamic acid group than in the control group (P < 0.05). According to Gross formula, the difference of hidden blood loss was statisticaly significant between the tranexamic acid group (302.9±189.9) mL and the control group (596.8±271.4) mL (P < 0.05). Deep vein thrombosis appeared in one case between the two groups after replacement. Results indicate that intravenous infusion of tranexamic acid dramaticaly decreased the hidden blood

  6. Isotopes Tell Sun's Origin and Operation

    Science.gov (United States)

    Manuel, O.; Kamat, Sumeet A.; Mozina, Michael

    2006-03-01

    Modern versions of Aston's mass spectrometer enable measurements of two quantities - isotope abundances and masses - that tell the Sun's origin and operation. Isotope analyses of meteorites, the Earth, Moon, Mars, Jupiter, the solar wind, and solar flares over the past 45 years indicate that fresh, poorly-mixed, supernova debris formed the solar system. The iron-rich Sun formed on the collapsed supernova core and now itself acts as a magnetic plasma diffuser, as did the precursor star, separating ions by mass. This process covers the solar surface with lightweight elements and with the lighter isotopes of each element. Running difference imaging provides supporting evidence of a rigid, iron-rich structure below the Sun's fluid outer layer of lightweight elements. Mass measurements of all 2,850 known nuclides expose repulsive interactions between neutrons that trigger neutron-emission at the solar core, followed by neutron-decay and a series of reactions that collectively generate solar luminosity, solar neutrinos, the carrier gas for solar mass separation, and an outpouring of solar-wind hydrogen from the solar surface. Neutron-emission and neutron-decay generate ~ 65% of solar luminosity; H-fusion ~ 35%, and ~ 1% of the neutron-decay product survives to depart as solar-wind hydrogen. The energy source for the Sun and other ordinary stars seems to be neutron-emission and neutron-decay, with partial fusion of the decay product, rather than simple fusion of hydrogen into helium or heavier elements.

  7. Member State Event: Telling CERN's Story

    CERN Multimedia

    2004-01-01

    As part of the events to mark the Laboratory's fiftieth anniversary, members of the CERN personnel are telling the story of CERN. Robert Cailliau (on the right of the photograph), co-inventor of the Web and currently responsible for CERN's external communications, and Chiara Mariotti (in the center), a physicist working at CMS, were invited to talk about the history of CERN and the Web at a conference in the 'Science Thursdays' series entitled 'From the Quark to the Web' in Turin on 26 February. This was not their first appearance before a non-specialist audience (almost 1000 people that day!) eager to find out what goes on in a unique research centre like CERN as talking about the Laboratory's activities and its history are part and parcel of their work for the Organization. Anniversary Events in the Member States: This 'Science Thursday' event devoted to CERN was one of Italy's contributions to CERN's fiftieth anniversary celebrations. Coming up soon in the Member States: Italy International Centre...

  8. 氨甲环酸用于全膝关节置换降低失血量的有效性及安全性%Tranexamic acid reduces blood loss in total knee arthroplasty:effectiveness and safety

    Institute of Scientific and Technical Information of China (English)

    曹万军; 朱绍灵; 刘显东; 唐承杰; 郑金文; 陈星宇; 刘颖; 肖鹏

    2015-01-01

    背景:氨甲环酸是一种人工合成的抗纤维蛋白溶解的药物,可以经静脉有效的控制全膝关节置换后失血。目的:观察氨甲环酸对初次行单侧全膝关节置换患者置换后失血的有效性及安全性。方法:选取2014至2015年在四川省骨科医院下肢科行单侧全膝关节置换的100例患者。以使用氨甲环酸与否分为试验组和对照组,各50例。试验组患者在全膝关节置换前10 min静脉注射氨甲环酸1 g,而对照组不给予氨甲环酸。结果与结论:试验组患者置换后围手术期总失血量、置换后24 h引流量、输血量明显少于对照组(P <0.05);试验组与对照组术中出血量、输血人数差异无显著性意义。两组患者患者置换前血红蛋白水平差异无显著性意义,而置换后血红蛋白水平均下降,且试验组患者置换后血红蛋白水平均明显高于对照组。置换后24 h,两组患者凝血功能差异无显著性意义。置换后6 d,2组患者双下肢静脉彩色多普勒超声检查均未见深静脉血栓。提示初次单侧全膝关节置换前静脉给予氨甲环酸能明显减少围手术期失血量及输血量,降低输血风险及输血费用,利于术后功能恢复,且不增加下肢深静脉血栓的风险。%BACKGROUND:Tranexamic acid is a synthetic anti-fibrinolytic drug, and can effectively control blood loss after total knee arthroplasty through vein. OBJECTIVE:To evaluate the effectiveness and safety of tranexamic acid in reducing blood loss after primary unilateral total knee arthroplasty. METHODS:From 2014 to 2015, 100 patients from the Department of Lower Limb, Sichuan Orthopaedic Hospital underwent primary unilateral total knee arthroplasty, and randomly divided into test group which used tranexamic acid and control group which used tranexamic acid, with 50 cases in each group. 1 g tranexamic acid was infused into the vein at 10 minutes before total knee arthroplasty

  9. Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter Activity.

    Science.gov (United States)

    Chatard, Morgane; Puech, Clémentine; Roche, Frederic; Perek, Nathalie

    2016-01-01

    Understanding cellular and molecular mechanisms induced by hypoxic stress is crucial to reduce blood-brain barrier (BBB) disruption in some neurological diseases. Since the brain is a complex organ, it makes the interpretation of in vivo data difficult, so BBB studies are often investigated using in vitro models. However, the investigation of hypoxia in cellular pathways is complex with physical hypoxia because HIF-1α (factor induced by hypoxia) has a short half-life. We had set up an innovative and original method of induction of hypoxic stress by hydralazine that was more reproducible, which allowed us to study its impact on an in vitro BBB model. Our results showed that hydralazine, a mimetic agent of the hypoxia pathway, had the same effect as physical hypoxia, with few cytotoxicity effects on our cells. Hypoxic stress led to an increase of BBB permeability which corresponded to an opening of our BBB model. Study of tight junction proteins revealed that this hypoxic stress decreased ZO-1 but not occludin expression. In contrast, cells established a defence mechanism by increasing expression and activity of their efflux transporters (Pgp and MRP-1). This induction method of hypoxic stress by hydralazine is simple, reproducible, controllable and suitable to understand the cellular and molecular mechanisms involved by hypoxia on the BBB. PMID:27337093

  10. Tranexamic Acid Reduce Blood Loss in Complex Posterior Lumbar Surgery%氨甲环酸对减少复杂腰椎后路手术围手术期出血的临床疗效

    Institute of Scientific and Technical Information of China (English)

    石厚银; 江锋; 谢显平; 马川; 胡旭光

    2016-01-01

    Objective To evaluate the efficacy of tranexamic acid on blood loss associated with complex posterior lumbar surgery. Methods 238 patients who received complex posterior lumbar surgery,from June 2013 to December 2015,were retrospectively analyzed. 123 patients were received tranexamic acid before incision in treatment group. 115 patients were not received tranexamic acid during perioperative period in the control group. Intraoperative estimated blood loss,postoperative drainage volume,amount of blood transfusion,hemoglobin and complications were compared. Results The average intraoperative estimated blood loss was significant difference between the groups[TXA group(523±153)ml vs. control group(785±188) ml,P=0.026]. The average postoperative drainage volume was significant difference too,between the groups[TXA group(265±84)ml vs. control group(381±105)ml,P=0.031]. The amount of blood transfusion was no statistical different between groups[TXA group(278±53)ml vs. control group(335±71)ml,P=0.187]. There was insignificantly different in operative time. Deep vein thrombosis and other adverse effects did not discover in both groups. Conclusion Tranexmaic acid is safe and effective in complex posterior lumbar surgery.%目的:观察氨甲环酸减少复杂腰椎后路手术围手术期出血的疗效与安全性。方法回顾2013年6月~2015年12月238例行复杂腰椎后路手术患者,其中氨甲环酸组123例,对照组115例。比较氨甲环酸组与对照组术中出血量,术后引流量,输血量,血红蛋白及深静脉血栓等。结果术中出血量:氨甲环酸组(523±153)ml,对照组(785±188)ml,差异有统计学意义(P=0.026);术后引流量:氨甲环酸组(265±84) ml,对照组(381±105)ml,差异有统计学意义(P=0.031);输血量:氨甲环酸组(278±53)ml,对照组(335±71)ml,差异无统计学意义(P=0.187);两组均未见深静脉血栓、肾功能

  11. Effectiveness of Tell Me More in Enhancing Communication Skills

    Directory of Open Access Journals (Sweden)

    Vivian A. Perez

    2014-12-01

    Full Text Available - Tell Me More is a language solution that contains modules of different topics and context that enable students to practice their listening, speaking, reading and writing skills incorporated in English courses. The study assessed the effectiveness of Tell Me More in enhancing the communication skills for measures to improve the implementation of the program. The participants of the study are 108,paramedical and non-paramedical students . A self-made instrument was utilized; the statistical tools include Weighted Mean and T-Test using PASW version 18.. Tell Me More is perceived Highly Effective in enhancing the listening and speaking skills of users while effective in enhancing the writing and reading skills. There is no significant difference between the responses of paramedical and non-paramedical students on the effectiveness of TELLL ME MORE. Users disagree that they encounter problems and conflicts in the use of Tell Me More. English teachers are advised to explore and utilize the modules and units related to writing and reading in order to improve users’ skills on the said areas. Additional or reinforcement activities may be given to complement the available modules. The yearly training or refresher course on the implementation of Tell Me More may be continued to ensure the smooth flow of the courseware utilization.

  12. Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice

    Directory of Open Access Journals (Sweden)

    Melariri P

    2015-02-01

    Full Text Available Paula Melariri,1 Lonji Kalombo,2 Patric Nkuna,2 Admire Dube,2,3 Rose Hayeshi,2 Benhards Ogutu,4,5 Liezl Gibhard,6 Carmen deKock,6 Peter Smith,6 Lubbe Wiesner,6 Hulda Swai2 1Polymers and Composites, Material Science and Manufacturing, Council for Scientific and Industrial Research, Port Elizabeth, South Africa; 2Polymer and Composites, Material Science and Manufacturing, Council for Scientific and Industrial Research, Pretoria, South Africa; 3School of Pharmacy, University of the Western Cape, Bellville, South Africa; 4Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi, Kenya; 5Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya; 6Division of Pharmacology, University of Cape Town Medical School, Groote Schuur Hospital, Cape Town, South Africa Abstract: Tafenoquine (TQ, a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (G6PD-deficient individuals. A microemulsion formulation of TQ (MTQ with sizes <20 nm improved the solubility of TQ and enhanced the oral bioavailability from 55% to 99% in healthy mice (area under the curve 0 to infinity: 11,368±1,232 and 23,842±872 min·µmol/L for reference TQ and MTQ, respectively. Average parasitemia in Plasmodium berghei-infected mice was four- to tenfold lower in the MTQ-treated group. In vitro antiplasmodial activities against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum indicated no change in half maximal inhibitory concentration, suggesting that the microemulsion did not affect the inherent activity of TQ. In a humanized mouse model of G6PD deficiency, we observed reduction in toxicity of TQ as delivered by MTQ at low but efficacious concentrations of TQ. We hereby report an enhancement in the solubility, bioavailibility, and efficacy of TQ against blood stages of Plasmodium parasites without a corresponding increase in toxicity

  13. How evolution tells us to induce allotolerance.

    Science.gov (United States)

    Land, Walter Gottlieb

    2015-04-01

    Modern immunology, in many ways, is based on 3 major paradigms: the clonal selection theory (Medawar, Burnet; 1953/1959), the pattern recognition theory (Janeway; 1989), and the danger/injury theory (Matzinger, Land; 1994). The last theory holds that any cell stress and tissue injury including allograft injury, via induction of damage-associated molecular patterns, induces immunity including alloimmunity leading to allograft rejection. On the other hand, the concept precludes that "non-self " per se induces immunity as proposed by the two former theories. Today, the danger/injury model has been largely accepted by immunologists, as documented by a steadily increasing number of publications. In particular, overwhelming evidence in support of the correctness of the model has come from recent studies on the gut microbiota representing a huge assemblage of "non-self. " Here, harmless noninjurious commensal microbes are protected by innate immunity-based immune tolerance whereas intestinal injury-causing pathogenic microbes are immunology attacked. The ability of the immune system to discriminate between harmless beneficial "non-self " to induce tolerance and harmful life-threatening "non-self " to induce immunity has apparently emerged during evolution: Protection of innate immunity-controlled beneficial "non-self " (eg, as reflected by microbiotas but also by the fetus of placental mammals) as well as immune defense responses to injuring/injured "non-self " (eg, as reflected by plant resistance to biotic and abiotic stress and allograft rejection in mammals) evolved under pressure across the tree of life, that is, in plants, lower and higher invertebrates as well as lower and higher vertebrates. And evolution tells us why the overall existence of protected microbiotas really makes sense: It is the formation of the "holobiont, " - a metaorganism - that is, the host plus all of its associated microorganisms that - in terms of a strong unit of selection in evolution

  14. Pants on fire: the electrophysiological signature of telling a lie.

    Science.gov (United States)

    Pfister, Roland; Foerster, Anna; Kunde, Wilfried

    2014-01-01

    Even though electroencephalography has played a prominent role for lie detection via personally relevant information, the electrophysiological signature of active lying is still elusive. We addressed this signature with two experiments in which participants helped a virtual police officer to locate a knife. Crucially, before this response, they announced whether they would lie or tell the truth about the knife's location. This design allowed us to study the signature of lie-telling in the absence of rare and personally significant oddball stimuli that are typically used for lie detection via electrophysiological markers, especially the P300 component. Our results indicate that active lying attenuated P300 amplitudes as well as N200 amplitudes for such non-oddball stimuli. These results support accounts that stress the high cognitive demand of lie-telling, including the need to suppress the truthful response and to generate a lie.

  15. The Regional Specifications of Story Telling of Khorasan

    Directory of Open Access Journals (Sweden)

    مشتاق مهر مشتاق مهر

    2011-05-01

    Full Text Available Regionalism in the contemporary Iranian story telling begins seriously in the 1930s and reaches its peak in the 1940s or 1950s. The regional stories reflect mostly the common specifications and elements, such as cultures, beliefs, rules and ceremonies in the geographical area. In the contemporary Iranian story telling, with respect to the geographical origins of writers and regional specifications reflected in their worksfive realms of regional story telling in the north, south, east (Khorasan, west (Kermanshah, and Adharbayejan are reflected After presenting the definition of regional story, This article critically counts and introduces regional stories of Khorasan and their specifications.. Key words: region, story, the manner of regional writing, Khorasan.

  16. Blood transfusions

    Science.gov (United States)

    ... called homologous blood donation. Many communities have a blood bank at which any healthy person can donate blood. ... need to arrange with your hospital or local blood bank before your surgery to have directed donor blood. ...

  17. 全膝关节置换术后不同体位和引流方法的失血量比较%Comparison on blood loss between different position and drainage method after total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    胡红嫣; 王利宏; 卢福娇

    2012-01-01

    Objective To study the effect of different position and drainage method on blood loss after total knee arthro-plasty. Method Select 30 patients after total knee arthroplasty. Divide them into Group A, B and C according to random number table. Patients in Group A take the position of extension knee with pillow under the ankle of affected extremity and indwelling vacuum-drainage bag. Patients in Group B take the position of extension knee with pillow under the ankle of affected extremity and indwelling unvacuum-drainage bag. Patients in Group C lift affected extremity at the angle of 30 degree, bend knee at the angle of 45 degree and indwelling unvacuum-drainage bag. Compare the volumes of drain 24h after operation, total blood transfusion and change of prc - operation and post - operation total protein and hemoglobin of three groups. Result The volumes of drain 24h after operation of Group A, B and C arc (970. 00±79. 54)ml, (719. 00 ± 83. 91) ml and (419. 00 ± 38. 74)ml (F=15. 36, P<0. 05). The total blood transfusion and loss of total protein and hemoglobin arc less in Group C. There is significant difference on comparison between Group C and other two groups. Conclusion Bent and lifting position and unvacuum-drainage for patients after total knee arthroplasty can help reduce postoperative blood loss.%目的 探讨全膝关节置换术后不同体位和引流方法对减少失血量的影响.方法 选择30例全膝关节置换术后患者,按随机数字表分为A组、B组和C组各10例.A组术后患肢踝后垫枕,膝关节伸直位,留置负压引流袋引流;B组术后患肢踝后垫枕,膝关节伸直位,留置非负压引流袋引流;C组术后患肢抬高30°、屈膝45°,留置非负压引流袋引流.比较3组术后24 h 切口引流量、术前和术后总蛋白及血红蛋白差值、总输血量.结果 A、B、C 3组术后24 h 切口引流量分别为(970.00±79.54)ml、(719.00±83.91)ml和(419.00±38.74)ml,经比较,F=15.36,P<0.05;C组患者

  18. Study of effectiveness and safety of tranexamic acid in reducing blood loss and blood transfusion rate of elderly hip fracture surgery%氨甲环酸减少老年髋部骨折手术失血量与输血率的有效性及安全性研究

    Institute of Scientific and Technical Information of China (English)

    杨明新; 于华; 赵金红; 苏杰

    2015-01-01

    Objective To investigate the effectiveness and safety of preoperative intravenous administration of tranex-amic acid in the hemiarthroplasty treatment of elderly hip fracture. Methods Seventy patients who received hemiarthro-plasty due to femoral neck fracture (Garden Ⅲ/Ⅳ) in our hospital from January 2008 to December 2012 were analyzed retrospectively, of which 35 patients were given preoperative intravenous administration of tranexamic acid and 35 pa-tients were not. The patients'preoperative and postoperative hemoglobin and hematocrit values were collected. The to-tal blood loss amount was calculated through Gross equation and the postoperative drainage amount, number of people receiving blood transfusion, blood transfusion amount and occurrence of thrombus events were recorded. Results The total blood loss amount of the tranexamic acid group was (867.79±76.93) mL, which was significantly lower than (1207.07±403.83) mL of the control group, with statistically significant difference(P=0.036). The postoperative drainage amount was (305.67±103.68) mL, which was lower than the (393.00±66.29) mL of the control group, with statistically significant difference (P<0.01). The application of tranexamic acid decreased the blood transfusion rate from 42.86% to 20.00%(P=0.039). The complications of postoperative thrombus events did not increase (P=0.643). Conclusion In the treatment of elderly femoral neck fracture, the preoperative intravenous administration of tranexamic acid can effec-tively and safely reduce the blood loss amount and blood transfusion rate of hemiarthroplasty.%目的:探讨术前静脉使用氨甲环酸在半髋关节置换术治疗老年髋部骨折中的有效性与安全性。方法回顾性分析我院2008年1月~2012年12月因股骨颈骨折(GardenⅢ/Ⅳ型)行半髋关节置换术患者70例,其中35例术前静脉使用氨甲环酸,35例未使用。收集患者的术前、术后血红蛋白及血细胞比容值,通过Gross方程计算

  19. Hearing Loss

    Science.gov (United States)

    ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Tools & ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Ask ...

  20. Effect of tranexamic acid on perioperative blood loss during transurethral resection of prostate%氨甲环酸对经尿道前列腺电切术失血量的影响

    Institute of Scientific and Technical Information of China (English)

    蒙倩倩; 熊君宇; 潘宁

    2014-01-01

    Objective To determine the effect of tranexamic acid on perioperative blood loss in patients who underwent transurethral resection of the prostate ( TURP) , as well as its safety.Methods A double blind randomized control trial was conducted from January 2012 to February 2013.In this trial, 30 patients of the tranexamic acid group (T group), between age of 55-85 years, underwent TURP and received 1 g of tranexamic acid in 200 mL normal saline after induction of anes-thesia and 30 patients of the control group (C group) received a placebo (normal saline only).The medicine dripping speed ranged 20-40 drops/minute.The amount of blood loss was measured during the operation and at 4 h and 24 h post-operatively and the difference between the two groups was analyzed.Coagulation profiles, including prothrombin time, thrombin time and fibrinogen level, were measured preoperatively and 4 h postoperatively.Any signs of thromboembolic e-vent especially in the lower limbs or within 7 days were noted.Results The blood losses during operation and 4 h postopera-tion were (102.0 ±11.4) mL and (61.9 ±6.1) mL, respectively in the T group and (303.6 ±24.8) mL and (84.8 ± 15.2) mL, respectively in the C group.The values were significantly lower in the T group compared to those in the C group (P<0.05).However, there was no significant difference at 24 h postoperative blood loss between the groups.The coagu-lation profiles in the two groups were statistically not relevant.There was no evidence of deep vein thrombosis in the lower limbs or in both groups.Conclusion Tranexamic acid can reduce intraoperative blood loss during TURP without increasing the risk of thrombosis.%目的:探讨人工合成的抗纤溶药物氨甲环酸对接受经尿道前列腺电切术的患者失血量的影响及其安全性。方法2012年1月—2013年2月行经尿道前列腺电切术的60例患者,随机双盲分为氨甲环酸组( T组)和空白对照组( C组),每组30例。 T组在麻

  1. Efficacy Analysis of a Script-based Guide for EVAR Execution: is it Possible to Reduce Patient Exposure to Contrast, Operative Time and Blood Loss even when Advanced Technologies are not Available?

    Directory of Open Access Journals (Sweden)

    Giovani José Dal Poggetto Molinari

    2015-12-01

    Full Text Available ABSTRACT INTRODUCTION: Despite the patient and medical staff exposure to radiation in endovascular aneurysm repair, the benefits of this abdominal aortic aneurysm type of surgical management are justfied by minor recovery time and hospitalization, as well as an option for patients not elected to conventional open repair. In this minimally invasive surgical aproach, time of procedure and radiation doses can be substantial - and the increasing frequency of these procedures and it's complexity have impelled vascular surgeons to face additional and successive risk to occupational radiation exposure. Meticulous study of the computed tomography angiography during the endovascular aneurysm repair preparation allows reduction of unnecessary radiation exposure, as also reduces consecutive image acquisition and contrast use (that may be related to renal overload in susceptible patients. Some studies have proposed strategies to optimize endovascular intervention to reduce contrast use and X-ray exposure. Although they might prove to be effective, they rely on use of additional specific and advanced equipment, available only in major centers. As an alternative to this expensive and restrict technology, it is presented a simpler technique through image manipulation on software OsiriX, aiming to reduce both exposures. OBJECTIVE: To analyze the efficacy of the adoption of a study protocol and a script-based guide in preparation for endovascular aneurysm repair through verifying it's impact over the surgical procedure - as referred to intravascular contrast infuse, effects over renal function, blood loss and operatory time. METHODS: A longitudinal prospective study from March 2014 through March 2015, where 30 performed endovascular aneurysm repair were compared to a historic control group. The planning for endovascular aneurysm repair through the patient's tomographic image manipulation in the prospective group was performed with OsiriX MD software. A script

  2. Mirror Neurons, the Development of Empathy, and Digital Story Telling

    Science.gov (United States)

    Hess, Mary

    2012-01-01

    This article explores the intersection of work in media education, religious education, concerns about digital cultures' impact on human relationality, and the possible role that mirror neurons might play in the development of empathy. Digital story telling--particularly as embodied in the work of the Center for Digital Storytelling…

  3. How Do Children Tell Us about Their Childhoods?

    Science.gov (United States)

    Samuelsson, Ingrid Pramling

    2004-01-01

    Noting that quality in early childhood education is related to the quality of communication and interaction among teachers and children, this article explores how teachers can facilitate children's telling others about their perspectives of the world. The paper asks the questions: "How do we as researchers and teachers interpret the child and…

  4. If You Listen, the Patient Will Tell You the Diagnosis

    Science.gov (United States)

    Holmes, Frederick

    2007-01-01

    Since the time of Hippocrates, professors in medical schools have been telling their students to listen to patients. Medical students and young doctors all come to realize that the medical history, the patient's account of his or her own illness, is the best source of information with which to make an accurate diagnosis. The physical examination,…

  5. Three Reading Comprehension Strategies: TELLS, Story Mapping, and QARs.

    Science.gov (United States)

    Sorrell, Adrian L.

    1990-01-01

    Three reading comprehension strategies are presented to assist learning-disabled students: an advance organizer technique called "TELLS Fact or Fiction" used before reading a passage, a schema-based technique called "Story Mapping" used while reading, and a postreading method of categorizing questions called "Question-Answer Relationships." (JDD)

  6. Number of endothelia progenitor cells from peripheral blood in patients with sudden sensorineural hearing loss%突发性耳聋患者外周血内皮祖细胞的变化

    Institute of Scientific and Technical Information of China (English)

    杨东; 周慧芳

    2012-01-01

    Objective: To investigate the number of endothelia progenitor cells (EPCs) from peripheral blood in patients with sudden sensorineural hearing loss(SSHL) and the proliferative number of EPCs colonies. Methods: Number of EPCs from peripheral blood and number of proliferative colonies of EPCs after 7 d were measured and comparison was made between SSHL group and the healthy group. Results: The number of EPCs reduced significantly in SSHL group compared with contrast group, they were (36.5?.58)/200xl03 cells and(85.3?.55)/200xl03 cells respectively. The number of proliferative colonies of EPCs were(2.01?.31) in SSHL group and (3.80眑.05) in normal group (P?0.01). Conclusion: Because the number of EPCs and the number of proliferative colonies of EPCs significantly lessen in patients with SSHL, EPCs cannot satisfy the body requirement during the process of restoration and result in the symptom of hearing loss.%目的:探讨突发性耳聋患者外周血中内皮祖细胞(EPCs)数量变化及增殖集落变化情况.方法:测定突发性耳聋患者和听力正常健康人外周血中EPCs数量及培养7d后增殖集落数量.结果:突发性耳聋组外周血中EPCs计数为(36.5±2.58)个/20万单个核细胞,听力正常健康人EPCs计数为(85.3±6.55)个/20万单个核细胞,EPCs增殖集落计数分别为(2.01±0.31)个和(3.80±1.05)个,两者比较差异具有统计学意义(P<0.01).结论:突发性耳聋患者由于EPCs数量及增殖集落数量下降,在机体修复过程中不能满足要求而引起耳聋等临床症状.

  7. Seven-day mortality can be predicted in medical patients by blood pressure, age, respiratory rate, loss of independence, and peripheral oxygen saturation (the PARIS score: a prospective cohort study with external validation.

    Directory of Open Access Journals (Sweden)

    Mikkel Brabrand

    Full Text Available Most existing risk stratification systems predicting mortality in emergency departments or admission units are complex in clinical use or have not been validated to a level where use is considered appropriate. We aimed to develop and validate a simple system that predicts seven-day mortality of acutely admitted medical patients using routinely collected variables obtained within the first minutes after arrival.This observational prospective cohort study used three independent cohorts at the medical admission units at a regional teaching hospital and a tertiary university hospital and included all adult (≥ 15 years patients. Multivariable logistic regression analysis was used to identify the clinical variables that best predicted the endpoint. From this, we developed a simplified model that can be calculated without specialized tools or loss of predictive ability. The outcome was defined as seven-day all-cause mortality. 76 patients (2.5% met the endpoint in the development cohort, 57 (2.0% in the first validation cohort, and 111 (4.3% in the second. Systolic blood Pressure, Age, Respiratory rate, loss of Independence, and peripheral oxygen Saturation were associated with the endpoint (full model. Based on this, we developed a simple score (range 0-5, ie, the PARIS score, by dichotomizing the variables. The ability to identify patients at increased risk (discriminatory power and calibration was excellent for all three cohorts using both models. For patients with a PARIS score ≥ 3, sensitivity was 62.5-74.0%, specificity 85.9-91.1%, positive predictive value 11.2-17.5%, and negative predictive value 98.3-99.3%. Patients with a score ≤ 1 had a low mortality (≤ 1%; with 2, intermediate mortality (2-5%; and ≥ 3, high mortality (≥ 10%.Seven-day mortality can be predicted upon admission with high sensitivity and specificity and excellent negative predictive values.

  8. Story-telling, Earth-Sciences and Geoethics

    Science.gov (United States)

    Bohle, Martin; Sibilla, Anna; Graells, Robert Casals i.

    2015-04-01

    People are engineers, even the artist. People like stories, even the engineers. Engineering shapes the intersections of humans and their environments including with the geosphere. Geoethics considers values upon which to base practices how to intersect the geosphere. Story-telling is a skilful human practice to describe perception of values in different contexts to influence their application. Traditional earth-centric narrations of rural communities have been lost in the global urbanisation process. These former-time narrations related to the "sacrum" - matters not possible to be explained with reasoning. Science and technology, industrialisation and global urbanisation require an other kind of earth-centric story-telling. Now at the fringe of the Anthropocene, humans can base their earth-centricity on knowledge and scientific thinking. We argue that modern story-telling about the functioning of Earth's systems and the impact of humankind's activities on these systems is needed, also in particular because citizens rarely can notice how the geosphere intersects with their daily dealings; putting weather and disasters aside. Modern earth-centric story-telling would offer citizens opportunities to develop informed position towards humankind's place within earth-systems. We argue that such "earth-science story-lines" should be part of the public discourse to engage citizens who have more or less "expert-knowledge". Understanding the functioning of the Earth is needed for economy and values suitable for an anthropophil society. Multi-faceted discussion of anthropogenic global change and geoengineering took off recently; emerging from discussions about weather and hazard mitigation. Going beyond that example; we illustrate opportunities for rich story-telling on intersections of humans' activities and the geosphere. These 'modern narrations' can weave science, demographics, linguistics and cultural histories into earth-centric stories around daily dealings of citizens

  9. Blood culture

    Science.gov (United States)

    Culture - blood ... A blood sample is needed . The site where blood will be drawn is first cleaned with an antiseptic such ... organism from the skin getting into (contaminating) the blood sample and causing a false-positive result (see ...

  10. Blood Thinners

    Science.gov (United States)

    If you have some kinds of heart or blood vessel disease, or if you have poor blood flow to your brain, your doctor may recommend that you take a blood thinner. Blood thinners reduce the risk of heart ...

  11. Blood Basics

    Science.gov (United States)

    ... Patient Group Links Advocacy Toolkit Home For Patients Blood Basics Blood is a specialized body fluid. It ... about 9 pints. Jump To: The Components of Blood and Their Importance Many people have undergone blood ...

  12. Blood pressure

    Science.gov (United States)

    ... the walls of the arteries is called blood pressure. Blood pressure is measured both as the heart contracts, which ... as it relaxes, which is called diastole. Normal blood pressure is considered to be a systolic blood pressure ...

  13. Management of major blood loss: an update

    DEFF Research Database (Denmark)

    Johansson, P I; Ostrowski, S R; Secher, N H

    2010-01-01

    Haemorrhage remains a major cause of potentially preventable deaths. Trauma and massive transfusion are associated with coagulopathy secondary to tissue injury, hypoperfusion, dilution and consumption of clotting factors and platelets. Concepts of damage control surgery have evolved, prioritizing...... coagulopathy of massive transfusion remains debated and randomized controlled studies are lacking. Results from recent before-and-after studies in massively bleeding patients indicate that trauma exsanguination protocols involving the early administration of plasma and platelets are associated with improved......, regardless of its cause, should be treated with goal-directed haemostatic control resuscitation involving the early administration of plasma and platelets and based on the results of the TEG/ROTEM analysis. The aim of the goal-directed therapy should be to maintain a normal haemostatic competence until...

  14. Perda auditiva induzida por ruído e hipertensão em condutores de ônibus Noise-induced hearing loss and high blood pressure among city bus drivers

    Directory of Open Access Journals (Sweden)

    Heleno Rodrigues Corrêa Filho

    2002-12-01

    Full Text Available OBJETIVO: Estimar as prevalências de perda auditiva induzida por ruído e hipertensão arterial em condutores de ônibus urbanos. MÉTODOS: Executou-se estudo transversal em amostra probabilística de 108 motoristas da cidade de Campinas, SP. Aplicou-se questionário sobre história profissional, jornadas de trabalho e repouso, e realizou-se exame físico e laboratorial incluindo medida da pressão arterial, audiometria tonal limiar, logoaudiometria e dados antropométricos, após a obtenção de consentimento. RESULTADOS: A prevalência de perda auditiva induzida por ruído foi de 32,7% do total examinado. Segundo a classificação de Merluzzi, nos 31 casos classificados em primeiro e segundo graus, observou-se que a freqüência audiométrica com perda auditiva mais acentuada foi a de 6 kHz (61,3%, seguida pela de 4 kHz (38,7%, sem diferenças significantes quanto à lateralidade. A prevalência de hipertensão arterial diastólica (PAD³90 mmHG; PAS³140 mmHG foi de 13,2% dos examinados. CONCLUSÕES: O risco de disacusia induzida por ruído foi maior para os motoristas com mais de seis anos de trabalho, após ajuste para a perda relacionada com a idade, com um odds ratio de 19,25 (1,59OBJECTIVE: To estimate the prevalence of occupational noise-induced hearing loss and arterial hypertension among city bus drivers. METHODS: A cross-sectional study was carried out on a probability random sample of 108 city bus drivers taken out of a total of 1,529 estimated professionals in the city of Campinas, Brazil, in 1991. Drivers were interviewed using questionnaires on job history, shift work and vacation schedules and underwent clinical and laboratory examinations including measures of blood pressure, pure-tone audiometry, speech audiometry, and anthropometric data analysis after an informed consent was obtained. RESULTS: The prevalence of noise-induced hearing loss was 32.7%. According to Merluzzi's classification, 91.2% (31 cases were classified as

  15. [Walter Matthias Diggelmann--the healing effect of story telling].

    Science.gov (United States)

    Schmid, H J

    2001-06-21

    "Stories are weapons against disease" wrote Swiss writer WM Diggelmann (1927-1979). In writing stories he hoped to counteract the lethal course of his cancer. In the past it had helped him to overcome destitution and social disgrace and had given him identity. His last story Walking on the Island of St. Margaret is a ritual which conjures up an intact future by celebrating the past. Stories try to explain the world. They inform or clarify emotions. In telling stories, doctors and nurses demonstrate sympathy and understanding. Perhaps even greater benefits might be derived from patients telling their own stories. In doing so they emerge as individuals and give their lives purpose. Language is more than communication: it is shelter, link, home, ritual. Storytelling helps patients cope with their diseases. It is not clear whether this or any technique of psychotherapy has any effect upon the course of cancer. PMID:11469056

  16. Kinds of Knowledge-Telling: Modeling early writing development

    Directory of Open Access Journals (Sweden)

    John R. Hayes

    2011-12-01

    Full Text Available The thesis of this article is that Bereiter and Scardamalia's (1987 knowledge-telling strategy may be viewed as a family of strategies. In particular, when young writers compose expository themes from their own knowledge, they may use one of three writing strategies: a flexible-focus strategy, a fixed-topic strategy, or a topic-elaboration strategy, all of which may be viewed as kinds of knowledge-telling. The article then proposes models to characterize the organization of cognitive processes in each strategy. The three writing strategies produce texts with identifiably different topical structures. Finally, the article provides evidence based on texts written by children in grades one through nine to indicate that the three strategies have distinct developmental trajectories.

  17. On telling the truth to patients with dementia

    OpenAIRE

    Marzanski, Marek

    2000-01-01

    Objectives To discover what dementia sufferers think is wrong with them, what they have been told and by whom, and what they wish to know about their illness. Background Ethical guidelines regarding telling truth appear to be equivocal. Declarations of cognitively intact subjects, attitudes of family members, and current psychiatric practice all vary, but no previous research has been published concerning what patients with dementia would like to know about their diagnosis and prognosis. Desi...

  18. Archaeological and chemical analysis of Tell el Yahudiyeh ware

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, M F; Harbottle, G; Sayre, E V

    1978-01-01

    Typological and geographic analyses indicate that Tell el Yahudiyeh ware (found in Cyprus, Egypt, Nubia, and the Levant during the Middle Bronze period, c. 1750-1550 B.C.) were probably manufactured in two areas, the Nile Valley and the Levant. Activation analysis was carried out and correlated with the archaeological analyses. Results confirm the two ''families'' of the ware, one Egyptian and one Levantine. Speculations are offered on the social interaction of the period. 11 figures, 2 tables. (DLC)

  19. Archaeological and chemical analysis of Tell el Yahudiyeh ware

    International Nuclear Information System (INIS)

    Typological and geographic analyses indicate that Tell el Yahudiyeh ware (found in Cyprus, Egypt, Nubia, and the Levant during the Middle Bronze period, c. 1750-1550 B.C.) were probably manufactured in two areas, the Nile Valley and the Levant. Activation analysis was carried out and correlated with the archaeological analyses. Results confirm the two ''families'' of the ware, one Egyptian and one Levantine. Speculations are offered on the social interaction of the period. 11 figures, 2 tables

  20. What does global mean temperature tell us about local climate?

    OpenAIRE

    Sutton, Rowan; Suckling, Emma; Hawkins, Ed

    2015-01-01

    The subject of climate feedbacks focuses attention on global mean surface air temperature (GMST) as the key metric of climate change. But what does knowledge of past and future GMST tell us about the climate of specific regions? In the context of the ongoing UNFCCC process, this is an important question for policy-makers as well as for scientists. The answer depends on many factors, including the mechanisms causing changes, the timescale of the changes, and the variables and regions of intere...

  1. Assessment of the effect on blood loss and transfusion requirements when adding a polyethylene glycol sealant to the anastomotic closure of aortic procedures: a case–control analysis of 102 patients undergoing Bentall procedures

    Directory of Open Access Journals (Sweden)

    Natour Ehsan

    2012-10-01

    Full Text Available Abstract Background The use of CoSeal®, a polyethylene glycol sealant, in cardiac and vascular surgery for prevention of anastomotic bleeding has been subject to prior investigations. We analysed our perioperative data to determine the clinical benefit of using polyethylene glycol sealant to inhibit suture line bleeding in aortic surgery. Methods From January 2004 to June 2006, 124 patients underwent aortic surgical procedures such as full root replacements, reconstruction and/or replacement of ascending aorta and aortic arch procedures. A Bentall procedure was employed in 102 of these patients. In 48 of these, a polyethylene glycol sealant was added to the anastomotic closure of the aortic procedure (sealant group and the other 54 patients did not have this additive treatment to the suture line (control group. Results There were no significant between-group differences in the demographic characteristics of the patients undergoing Bentall procedures. Mean EuroSCORES (European System for Cardiac Operative Risk Evaluation were 13.7 ± 7.7 (sealant group and 14.4 ± 6.2 (control group, p = NS. The polyethylene glycol sealant group had reduced intraoperative and postoperative transfusion requirements (red blood cells: 761 ± 863 versus 1248 ± 1206 ml, p = 0.02; fresh frozen plasma: 413 ± 532 versus 779 ± 834 ml, p = 0.009; and less postoperative drainage loss (985 ± 972 versus 1709 ± 1302 ml, p = 0.002. A trend towards a lower rate of rethoracotomy was observed in the sealant group (1/48 versus 6/54, p = 0.07 and there was significantly less time spent in the intensive care unit or hospital (both p = 0.03. Based on hypothesis-generating calculations, the resulting economic benefit conferred by shorter intensive care unit and hospital stays, reduced transfusion requirements and a potentially lower rethoracotomy rate is estimated at €1,943 per patient in this data analysis

  2. Common Weight Loss Challenges

    Science.gov (United States)

    ... tell me that they’ve been drinking sugary soft drinks all their lives, and they’re not willing ... some ground. If they need to have sugary soft drinks, ask them to indulge at work and leave ...

  3. Memory loss

    Science.gov (United States)

    A person with memory loss needs a lot of support. It helps to show the person familiar objects, music, or and photos or play familiar music. Write down when the person should take any medicine or do other ...

  4. History of a Bronze Age tell and its environment

    Science.gov (United States)

    Kovács, Gabriella; Füleky, György; Vicze, Magdolna

    2016-04-01

    Százhalombatta-Földvár is the most excessively researched Bronze Age tell site in Hungary. Parallel to the investigation of the settlement structure and activity patterns the changes of the landscape and the effect of human alteration is also studied. Significant changes of the landscape can be detected from the Bronze Age until the recent natural and cultural heritage protection of the area. Archaeological, soil analytical and thin section soil micromorphological methods are used to reconstruct the past 4000 years of the tell and its immediate surroundings. Prior to the Bronze Age the area was covered by forest vegetation, so the initial settling could only be realised after deforestation (2000 BC). The result of the soil corings and the prepared soil thin sections are solid proves of this action. It also became evident that at some areas - so far it seems that at locales where house floors were laid for the very first time - even the topsoil was removed so intensively that only the B horizon of the relict forest soil can be found. This observation needs to be further tested outside the habitation area to define the horizontal extension of the forest clearance and the topsoil removal. The northern side of the settlement is bordered by a natural erosion gully. At 2000 BC it was just a natural depression, but by 1500 BC it was deepened to serve as a fortification ditch. Around 1200 BC the ditch started to be filled in and by 1000 BC it was refilled to such an extent that its surface was utilised again. At about 600 BC (Late Iron Age) a smaller inner rampart was erected on the southern side of the ditch for inner separation. Not much is known about the Roman period of this area (200 AD) but the remnants of a watchtower indicate their presence. During the 18th century AD the area was used for grape cultivation and later for hobby gardens up until the protection of the area in the late 20th century. Since then species of the original vegetation started to grow back

  5. Blood Types

    Science.gov (United States)

    ... How Can I Help a Friend Who Cuts? Blood Types KidsHealth > For Teens > Blood Types Print A A ... or straight hair instead of curly. ...Make Eight Blood Types The different markers that can be found in ...

  6. Immunoelectrophoresis - blood

    Science.gov (United States)

    IEP - serum; Immunoglobulin electrophoresis - blood; Gamma globulin electrophoresis; Serum immunoglobulin electrophoresis ... A blood sample is needed. For information on how this is done, see: Venipuncture

  7. Impaction of iron supplement combined with tranexamic acid on perioperative blood loss and safety of unilateral total knee ar-throplasty%铁剂与氨甲环酸联合应用对单侧全膝关节置换术围手术期失血及安全性的影响

    Institute of Scientific and Technical Information of China (English)

    孟涛; 尚希福

    2015-01-01

    Objective To explore and discuss the efficacy and safety of iron supplement combined with tranexamic acid in reducing perioperative blood loss of unilateral total knee arthroplasty(TKA). Methods 142 patients suffered from unilateral knee osteoarthritis and underwent primary TKA in our hospital from July to December in 2014 were enrolled in this study,then they were randomly divided into study group(76 cases)and control group(66 cases). Besides the same treatment as the control group,patients in the study group were given oral iron supplement during 2 weeks before and after the operation,and during the operation they received intra - articular injection of tranexamic acid(1. 0 g)and 20 mL normal saline after suturing and intravenous tranexamic acid(15 mg/ kg)at 20 min before tourniquet release. The amounts of intraoperative blood loss,hidden blood loss,total blood loss and postoperative drainage,the number of patients needing blood transfusion,the operation time,and results of blood Hb,Hct,PT,APTT,FIB of the two groups before and after the operation were recorded and analyzed. Results The differences of preoperative general conditions and examinations of patients were of no statistically significant be-tween the two groups(P > 0. 05). There was no significant difference in operation time,intraoperative blood loss and postoperative levels of PT,APTT and FIB between the two groups(P > 0. 05). Results of Hb and Hct of the study group at 1 day,3 days,2 weeks after operation were significantly higher than those of the control group(P 0.05);两组患者手术时间、术中失血量、术后 FIB、PT、APTT 比较,差异无统计学意义(P >0.05),观察组术后1天、3天、2周时 Hb 及 Hct 均高于对照组(P <0.05),观察组术后引流量、隐性失血量、总失血量及输血人数均少于对照组(P <0.05)。结论联合应用铁剂和氨甲环酸可安全、有效地减少单侧 TKA 围手术期的失血,促进患者术后 Hb、Hct 水平的恢复。

  8. Hidden loss

    DEFF Research Database (Denmark)

    Kieffer-Kristensen, Rikke; Johansen, Karen Lise Gaardsvig

    2013-01-01

    to participate. RESULTS: All children were affected by their parents' ABI and the altered family situation. The children's expressions led the authors to identify six themes, including fear of losing the parent, distress and estrangement, chores and responsibilities, hidden loss, coping and support. The main......PRIMARY OBJECTIVE: The purpose of this study was to listen to and learn from children showing high levels of post-traumatic stress symptoms after parental acquired brain injury (ABI), in order to achieve an in-depth understanding of the difficulties the children face in their everyday lives...... finding indicates that the children experienced numerous losses, many of which were often suppressed or neglected by the children to protect the ill parents. CONCLUSIONS: The findings indicated that the children seemed to make a special effort to hide their feelings of loss and grief in order to protect...

  9. Experiencing Loss

    DEFF Research Database (Denmark)

    Kristiansen, Maria; Younis, Tarek; Hassani, Amani;

    2015-01-01

    In this article, we explore how Islam, minority status and refugee experiencesintersect in shaping meaning-making processes following bereavement. We do this througha phenomenological analysis of a biographical account of personal loss told by Aisha, a Muslim Palestinian refugee living in Denmark...

  10. I vote the young lady tells us a story

    OpenAIRE

    Busby, Lisa

    2012-01-01

    I vote the young lady tell us a story turns ephemeric readymade items into small interactive audio playback devices suitable for DJ-ing existing audio. This work presented a series of new compositions (in response to the theme of ‘Alice in Wonderland’ as set by the initial commissioning gallery - the compositions were intended to loosely ‘score’ the Carroll books) which were resonated using piezo disc systems through a series of 12 ephemeric readymades. These resonators were DJ-ed alongside e...

  11. Memory as resistance, and the telling of a dream.

    Science.gov (United States)

    Gray, P

    1992-01-01

    Traditional analytic orientation to memory as subject to repression has overshadowed examination of some of the ego's other activities bearing on memory. The author examines the defensive use of memory with the analytic goal of maximum autonomous access for the patient to the ego's previously unconscious management of intrapsychic conflict. A close scrutiny of an example of this in the form of the telling of a dream explores this resistance process and illustrates a technical approach. Some aspects of this perspective are considered in relation to traditional approaches to dream material. Certain technical priorities for differing clinical settings are discussed. PMID:1593074

  12. FORTUNE TELLINGS THAT RELATED FRUITS / MEYVELERIN DILINDEN FAL VE ISARETLER

    OpenAIRE

    Dr. Saadettin EĞRİ

    2008-01-01

    This study discusses the meanings attributed tovarious fruit in the fortune telling book Hursidname.Hursidname is located in the Library of Manuscripts andAncient Printed Books in Bursa and it’s characteristicsare interesting. It was written in the 18th century bySıdki and it is the only copy. In this book there are 36fruit and plant names. Every fruit’s loacations in the textwere given and all the fruit’s means were defined.Generally in this book there are some expectations andinformations a...

  13. Tell me your story: recovering from a difficult birth.

    Science.gov (United States)

    Norriss, Roma; Dansby, Binnie

    2016-01-01

    The authors discuss their experience of running after birth workshops as an intervention for women struggling to come to terms with a difficult birth experience. Midwives can use this approach in their practice with women in the postnatal period and also when preparing for a subsequent birth or even during a labour that follows a challenging experience. This article explores the value of supporting women to tell their story and how to do that with suggestions to build on listening skills. It also offers suggestions for self care, so that midwives can be well resourced for emotional support.

  14. Artificial blood

    Directory of Open Access Journals (Sweden)

    Sarkar Suman

    2008-01-01

    Full Text Available Artificial blood is a product made to act as a substitute for red blood cells. While true blood serves many different functions, artificial blood is designed for the sole purpose of transporting oxygen and carbon dioxide throughout the body. Depending on the type of artificial blood, it can be produced in different ways using synthetic production, chemical isolation, or recombinant biochemical technology. Development of the first blood substitutes dates back to the early 1600s, and the search for the ideal blood substitute continues. Various manufacturers have products in clinical trials; however, no truly safe and effective artificial blood product is currently marketed. It is anticipated that when an artificial blood product is available, it will have annual sales of over $7.6 billion in the United States alone.

  15. TellTable: Collaborative Work Using Single User Applications

    Directory of Open Access Journals (Sweden)

    John C. Nash

    2009-07-01

    Full Text Available Many work environments require collaborative writing and editing of documents in diverse formats. In simple cases, there is essentially one author who receives approvals and comments from others. In other cases, the document is genuinely collaboratively authored using asynchronous or synchronous methods. A common way to collaboratively edit a document is to exchange draft versions between authors via email. This method introduces the possibility of conflicting changes and missed contributions as well as a significant burden as all members of the team are responsible for version control. The principle difficulty is that independent changes can be made to different versions, which must later be reconciled manually. It is also difficult to determine when and why a change was made. This article introduces TellTable, an open source system designed to allow single-user software applications to be managed in a collaborative manner. We will discuss current collaboration models, the technical aspects of the TellTable software framework, security issues in its implementation, and tests of performance.

  16. The Analysis of the Gothic Element--High Emotion in The Tell-tale Heart

    Institute of Scientific and Technical Information of China (English)

    李莎

    2014-01-01

    The Tell-tale Heart is one of the most typical gothic novel of Allen Poe’s. This article intends to analyse one of the gothic elements, that is, high emotion which is employed in The Tell-tale Heart to contribute to the horror effect.

  17. The Analysis of the Gothic Element——High Emotion in The Tell-tale Heart

    Institute of Scientific and Technical Information of China (English)

    李莎

    2014-01-01

    The Tell-tale Heart is one of the most typical gothic novel of Allen Poe’s. This article intends to analyse one of the gothic elements, that is, high emotion which is employed in The Tell-tale Heart to contribute to the horror effect.

  18. Burning Down the House: the Burnt Building V6 at Late Neolithic Tell Sabi Abyad, Syria

    DEFF Research Database (Denmark)

    Akkermans, Peter M.M.G.; Brüning, Merel L.; Hammers, Neeke Mineke;

    2012-01-01

    This article presents the remains of a T-shaped burnt building found in trench V6 in Operation II at Late Neolithic Tell Sabi Abyad, Syria. The burnt building closely resembles the so-called Burnt Village excavated earlier at Tell Sabi Abyad in Operation I, level 6, but is slightly older. Many...

  19. Lying and Truth-Telling in Children: From Concept to Action

    Science.gov (United States)

    Xu, Fen; Bao, Xuehua; Fu, Genyue; Talwar, Victoria; Lee, Kang

    2010-01-01

    Although there has been extensive research on children's moral knowledge about lying and truth-telling and their actual lie- or truth-telling behaviors, research to examine the relation between these two is extremely rare. This study examined one hundred and twenty 7-, 9-, and 11-year-olds' moral understanding of lies and their actual lying…

  20. Telling Stories and Talking Facts: First Graders' Engagements in a Nonfiction Book Club

    Science.gov (United States)

    Heller, Mary F.

    2006-01-01

    Four 6-year-old girls participated in a nonfiction book club during reading/language arts classes. Ten of the sessions featured illustrated nonfiction. The girls' oral and written response to the texts involved telling stories (personal and fictional) and talking facts (literal telling/retelling), with the latter being predominate. The girls were…

  1. Using Precision Teaching to Teach Story Telling to a Young Child with Autism

    Science.gov (United States)

    Schirmer, Kristin; Almon-Morris, Holly; Fabrizio, Michael A.; Abrahamson, Brenda; Chevalier, Katie

    2007-01-01

    Story telling is a very important skill for children to have. The ability to recall information as well as to infer, embellish, and make up stories is critical to living as a successful social member of society. The Chart presented in this article demonstrates the progress one child with autism made in telling both fiction and nonfiction stories.

  2. 16 CFR 460.16 - What new home sellers must tell new home buyers.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false What new home sellers must tell new home buyers. 460.16 Section 460.16 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.16 What new home sellers must tell new home buyers....

  3. 'Popper'-induced vision loss.

    Science.gov (United States)

    Krilis, Matthew; Thompson, Julia; Atik, Alp; Lusthaus, Jed; Jankelowitz, Stacey

    2013-05-01

    Amyl nitrite 'poppers' are recreational drugs, which are a potent source of nitric oxide. The use of 'poppers' can cause psychoactive stimulation, reduced blood pressure, tachycardia and involuntary muscle relaxation. Their use is becoming increasingly common around the world, including approximately 60% of Australia's male homosexual community. We report the first case of 'popper'-induced vision loss in Australasia.

  4. Blood smear

    Science.gov (United States)

    ... osmotic fragility ) Deficiency of an enzyme called lecithin cholesterol acyl transferase Abnormalities of hemoglobin , the protein in ... sickle and Pappenheimer Red blood cells, target cells Formed elements of blood References Bain BJ. The peripheral ...

  5. Influence of the application timing in tranexamic acid therapy on the blood loss of patients with total hip arthroplasty%氨甲环酸应用时机对髋关节置换手术患者失血量影响的研究

    Institute of Scientific and Technical Information of China (English)

    甘伟伟; 刘斌; 谢贵杰

    2014-01-01

    Objective To discuss the impact of the application timing in tranexamic acid therapy on the blood loss of patients with pre-liminary total hip arthroplasty.Methods Ninety patients with preliminary total hip arthroplasty were assigned into early stage group (n=30,tranexamic acid at preoperative one hour),advanced stage group (n=30,tranexamic acid in operation),and control group (n=30,without tranexamic acid).The visible red blood cell loss,hidden red blood cell loss,and total red blood cell loss were analyzed.Re-sults (1)The visible red blood cell loss in control group (96.3 ±21.7)mL was significantly more than early stage group (45.9 ± 9.7)mL and advanced stage group (46.2 ±9.5)mL,Ps0.05).(2)The hidden red blood cell loss in early stage group (140.6 ±21.1)mL and advanced stage group (216.7 ±48.6)mL were significantly lower than control group (335.1 ±60.3)mL,Ps<0.01.Moreover,hidden red blood cell loss in early stage group was significantly lower than advanced stage group (P<0.01).(3)The total red blood cell loss in early stage group (236.7 ±42.4)mL and advanced stage group (344.0 ±51.5)mL were significantly lower than control group (492.8 ±65.1) mL,Ps<0.01.The total red blood cell loss in early stage group was significantly lower than advanced stage group (P<0.01).Conclu-sions Tranexamic acid reduces the blood loss in preliminary total hip arthroplasty,especially reducing hidden blood loss when used at preoperative one hour.%目的:探讨不同时间使用氨甲环酸对初次行髋关节置换术患者失血量的影响。方法将90例初次行髋关节置换术的患者按随机数字表法分为:早期组(30例,氨甲环酸术前1 h使用)、晚期组(30例,氨甲环酸术中使用)和对照组(30例,不使用)。统计分析患者的显性红细胞丢失量、隐性红细胞丢失量与总红细胞丢失量。结果(1)对照组(96.3±21.7)mL的显性失血量显著多于早期组(45.9±9.7)mL、晚期组(46

  6. VALIDEZ DE LA ESTIMACIÓN VISUAL COMO MÉTODO DIAGNÓSTICO DE LA HEMORRAGIA POSTPARTO SEVERA EN UN HOSPITAL UNIVERSITARIO. BOGOTÁ. 2007 Validity of visual estimation of blood loss as diagnostic tool in severe post partum hemorrhage in an university hospital. Bogotá. 2007

    Directory of Open Access Journals (Sweden)

    Jorge Andrés Rubio-Romero

    2010-07-01

    immediately after vaginal delivery. Material and methods. A diagnostic accuracy study was carried out in a cohort of pregnant women who had a vaginal delivery at an university hospital. It was approved by the ethics and investigation committees of participating institutions. A complex gold standard combining clinical and laboratory signs was defined: need of therapeutic maneuvers for treatment of post partum hemorrhage, drop of 10% or more of previous hematocrit or need of transfusion. Results. Incidence of SPPH was 10,7% of the 168 patients included. Median volume of estimated blood loss was 375 mL while median real observed blood volume was 475 mL. For the diagnosis of SPPH, estimated blood loss greater than 500 mL had a sensitivity and specificity of 77,8 y 73,3% respectively. For estimated blood loss greater than 800 mL, sensitivity and specificity were 44,4 and 94%. This cut point is the one that better classifies puerperal women requiring initial treatment for diagnose an abnormal hemorrhage of the post partum. Conclusions. Visual estimation of blood loss during delivery is a poorly sensitive and specific diagnostic test for the diagnosis of SPPH due to underestimation of the real magnitude of the blood loss occurred. Key words: validity of tests, reproducibility of results, sensitivity and specificity, postpartum hemorrhage. Rubio-Romero JA, Guevara-Cruz OA, Gaitán- Duarte H. Validity of visual estimation of blood loss as diagnostic tool in severe post partum hemorrhage in an university hospital. Bogotá. 2007. Rev.Fac.Med. 2010; 58: 173-184.

  7. 初次单侧骨水泥型全膝关节置换:氨甲环酸使用方式对失血量的影响%Primary unilateral cemented total knee arthroplasty:effect of tranexamic acid usage on blood loss

    Institute of Scientific and Technical Information of China (English)

    侯振扬; 苏长征; 庞涛; 吕东; 朱彪; 孙义玲; 李振; 柴星宇; 许正文

    2015-01-01

      结果与结论:B组及C组患者显性失血量和隐性失血量均较A组明显减少,差异有显著性意义(P0.05),在隐性失血量方面B组显著小于C组(P OBJECTIVE:To explore and discuss the effect of tranexamic acid and different usage methods on blood loss in the perioperative period of primary unilateral cemented total knee arthroplasty. METHODS:Sixty patients who were candidates for unilateral cemented total knee replacement in the Second Department of Joint Sports Medicine, Tengzhou Central People’s Hospital, from January 2013 to June 2014, were included in this study. Al patients were randomly divided into three groups. Group A (n=20):patients were injected with 100 mL normal saline through intravenous drip when the operation began, and then with 10 mL normal saline through intra-articular injection after skin closure. Group B (n=20):patients were injected with 10 mg/kg tranexamic acid which was dissolved in 100 mL normal saline when the operation began, and then with 10 mL normal saline through intra-articular injection after skin closure. Group C (n=20):patients were injected with 100 mL normal saline when the operation began, and then with 500 mg tranexamic acid dissolved in 10 mL normal saline through intra-articular injection after skin closure. The dominant blood loss, hidden blood loss, blood transfusion ratio and per capita of each group were compared. Clinical symptoms of pulmonary embolism and lower limb deep vein thrombosis were observed. Doppler ultrasound examine on lower extremity would be performed if necessary. RESULTS AND CONCLUSION:Dominant and hidden blood loss of patients from groups B and C were significantly lower than that of patients from group A (P0.05), the hidden blood loss in group B was significantly less than that in group C (P<0.05). The transfusion population and ratio of patients from groups B and C were significantly lower than that of patients from group A (P<0.05). In al three groups, no deep

  8. Use of blood and blood products.

    Science.gov (United States)

    Hunt, E; Wood, B

    1999-11-01

    It is sometimes necessary for the practitioner to transfuse the ruminant with whole blood or plasma. These techniques are often difficult to perform in practice, are time-consuming, expensive, and stressful to the animal. Acute loss of 20% to 25% of the blood volume will result in marked clinical signs of anemia, including tachycardia and maniacal behavior. The PCV is only a useful tool with which to monitor acute blood loss after intravascular equilibration with other fluid compartments has occurred. An acutely developing PCV of 15% or less may require transfusion. Chronic anemia with PCV of 7% to 12% can be tolerated without transfusion if the animal is not stressed and no further decline in erythrocyte mass occurs. Seventy-five percent of transfused bovine erythrocytes are destroyed within 48 hours of transfusion. A transfusion rate of 10 to 20 mL/kg recipient weight is necessary to result in any appreciable increase in PCV. A nonpregnant donor can contribute 10 to 15 mL of blood/kg body weight at 2- to 4-week intervals. Sodium citrate is an effective anticoagulant, but acid citrate dextrose should be used if blood is to be stored for more than a few hours. Blood should not be stored more than 2 weeks prior to administration. Heparin is an unsuitable anticoagulant because the quantity of heparin required for clot-free blood collection will lead to coagulation defects in the recipient. Blood cross-matching is only rarely performed in the ruminant. In field situations, it is advisable to inject 200 mL of donor blood into the adult recipient and wait 10 minutes. If no reaction occurs, the rest of the blood can probably be safely administered as long as volume overload problems do not develop. Adverse reactions are most commonly seen in very young animals or pregnant cattle. Signs of blood or plasma transfusion reaction include hiccoughing, tachycardia, tachypnea, sweating, muscle tremors, pruritus, salivation, cough, dyspnea, fever, lacrimation, hematuria

  9. 静脉滴注联合关节腔内使用氨甲环酸对初次全膝关节置换术后隐性失血的效果%The effect on intravenous and intra-articular cavity injection of tranexamic acid on recessive loss of blood in primary total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    侯颖周; 王少华; 魏瑄; 宋树春; 王爱国

    2016-01-01

    目的 探讨氨甲环酸在减少膝关节置换术后隐性失血的效果.方法 将100例人工全膝关节置换(TKR)患者随机平均分为2组:氨甲环酸组和对照组.切皮前15 min均使用氨甲环酸0.5g静脉滴注,术后氨甲环酸组在松止血带前给予氨甲环酸0.5g静脉滴注,同时在关闭切口后由引流管逆行灌入2%氨甲环酸25 ml,而对照组予以等量生理盐水静脉滴注和灌入.术后2d分别计算总失血量、术中失血量、术后引流量、隐性失血量和输血率.结果 氨甲环酸组的总失血量、置换术后引流量、隐性失血量、输血率分别为(0.326±0.221)L、(0.048±0.018)L、(0.210±0.113)L、(0.231±0.176)L、19%,低于对照组的(1.012±0.520)L、(0.056±0.012)L、(0.402±0.231)L、(0.532±0.514)L、65%,差异均有统计学意义(P<0.05).结论 氨甲环酸在减少膝关节置换术后隐性失血方面效果显著.%Objective The effection of tranexamic acid in recessive loss of blood in primary total knee arthroplasty.Methods One hundred patients having primary total knee arthroplasty were randomly divided into 2 groups,the tranexamic acid group and the control group,with 50 patients in each.the groups,0.5 g tranexamic acid was infused intravenously within 15 minutes befor skin incision,before deflation of the tourniquet,the tranexamic acid group accepted 0.5 g tranexamic acid and 25 ml intra-articular cavity injection of tranexamic acid intravenously,while an equal volume of normal saline was given instead in the control group.After 2 days,respectively calculate the total amount of blood loss,intraoperative blood loss,postoperative drainage,hidden blood loss and transfusion rates.Results The total amount of blood loss tranexamic acid group and the control group,after the replacement of drainage,hidden blood loss and transfusion rate in the ranexamic acid group were (0.326 ±0.221) L,(0.048 ±0.018) L,(0.210 ±0.113) L,(0.231 ±0.176) L,19%,lower than the control

  10. Beware of Products Promising Miracle Weight Loss

    Medline Plus

    Full Text Available ... the market in October 2010 because it caused heart problems and strokes. “We’ve also found weight- ... of weight loss products, including increased blood pressure, heart palpitations (a pounding or racing heart), stroke, seizure ...

  11. Beware of Products Promising Miracle Weight Loss

    Medline Plus

    Full Text Available ... are imported, sold online, and heavily promoted on social media sites. Some can also be found on ... use of weight loss products, including increased blood pressure, heart palpitations (a pounding or racing heart), stroke, ...

  12. Beware of Products Promising Miracle Weight Loss

    Medline Plus

    Full Text Available ... Medical Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products For Consumers Home For ... Contaminated Weight Loss Products More in Consumer Updates Animal & Veterinary Children's Health Cosmetics Dietary Supplements Drugs Food ...

  13. Cord Blood

    Directory of Open Access Journals (Sweden)

    Saeed Abroun

    2014-05-01

    Full Text Available   Stem cells are naïve or master cells. This means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. Stem cells are found in many parts of the human body, although some sources have richer concentrations than others. Some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and human embryos, which last one are controversial and their use can be illegal in some countries. Cord blood is a sample of blood taken from a newborn baby's umbilical cord. It is a rich source of stem cells, umbilical cord blood and tissue are collected from material that normally has no use following a child’s birth. Umbilical cord blood and tissue cells are rich sources of stem cells, which have been used in the treatment of over 80 diseases including leukemia, lymphoma and anemia as bone marrow stem cell potency.  The most common disease category has been leukemia. The next largest group is inherited diseases. Patients with lymphoma, myelodysplasia and severe aplastic anemia have also been successfully transplanted with cord blood. Cord blood is obtained by syringing out the placenta through the umbilical cord at the time of childbirth, after the cord has been detached from the newborn. Collecting stem cells from umbilical blood and tissue is ethical, pain-free, safe and simple. When they are needed to treat your child later in life, there will be no rejection or incompatibility issues, as the procedure will be using their own cells. In contrast, stem cells from donors do have these potential problems. By consider about cord blood potency, cord blood banks (familial or public were established. In IRAN, four cord blood banks has activity, Shariati BMT center cord blood bank, Royan familial cord blood banks, Royan public cord blood banks and Iranian Blood Transfusion Organ cord blood banks. Despite 50,000 sample which storage in these banks, but the

  14. Tell el Yahudiyeh Ware: a re-evaluation

    International Nuclear Information System (INIS)

    The TY (Tell el Yahudiyeh ware) project has implications for understanding the cultural interactions. The Second Intermediate Period (1750-1550 B.C.), one during which centraized government in Egypt collapses and, it is generally assumed, so does her trade network. Foreigners - the Hyksos - are able to enter the country and rule at least part of it. Results of this study (which includes activation analysis), however, indicate the TY is primarily an Egyptian pottery which appeared before the Hyksos entered and may have continued in use after they left. It cannot, therefore, be tightly associated with the Hyksos nor can it be used to judge the extent of their influence. Its wide distribution shows that Egypt continued to trade goods outside her boundaries throughout this period. Finally, not only goods travelled between what were generally considered to have been hostile neighbors, but the trade appears to have included ideas and technology as well

  15. FORTUNE TELLINGS THAT RELATED FRUITS / MEYVELERIN DILINDEN FAL VE ISARETLER

    Directory of Open Access Journals (Sweden)

    Dr. Saadettin EĞRİ

    2008-10-01

    Full Text Available This study discusses the meanings attributed tovarious fruit in the fortune telling book Hursidname.Hursidname is located in the Library of Manuscripts andAncient Printed Books in Bursa and it’s characteristicsare interesting. It was written in the 18th century bySıdki and it is the only copy. In this book there are 36fruit and plant names. Every fruit’s loacations in the textwere given and all the fruit’s means were defined.Generally in this book there are some expectations andinformations about health, richness, chair, journey,sadness, beauty, pain, life, commerce, friends andenemies. There are good predictions for each person whomake a wish .

  16. AIDS and journalism. Trying to tell too clear a story.

    Science.gov (United States)

    Cohen, J

    1994-12-01

    Much in science is complex. Scientists, by definition, work within the realm of complex hypothesis, empirical evidence, and proof. Questions, answers, details, complexities; that is the domain of the scientist. Journalists, on the other hand, are paid to develop and present stories which are clearly read and interpreted by the general public. The mechanics and dynamics of HIV and AIDS are among the most complex scientific challenges in the history of humankind. Journalists calling upon scientists to obtain and report clear, concise, information about the agent and its resulting pandemic are therefore surely not always going to receive simple, readily reportable responses. HIV is a moving target upon which research continues. While there are some definitively affirmative and some definitively negative factors about HIV, the gray areas and speculation remain vast. The author gives a few examples of AIDS stories which the media mishandled because they were trying to tell too clear a story. He then discusses stories flawed because scientists managed to present clear information about which journalists were overly skeptical. In one case, the public was informed that AIDS vaccines were not working, with headlines which insinuated that the vaccines themselves were causing infections. None of the vaccines, however, contained infectious materials. As a result, people became overly fearful of participating in HIV vaccine trials. Coverage of the potential identification of HIV-3 was premature and only scared people, while Rolling Stone magazine's article hypothesizing the origin of HIV via trials of a contaminated polio vaccine in the Belgium Congo in the late 1950s should not have been published. Clear answers about HIV/AIDS are few and far between, but interesting and significant stories can still be found; they are just hard to tell. PMID:12319130

  17. 全髋置换局部应用氨甲环酸后输血及成本效益分析%Postoperative Blood Loss,Transfusion and Cost Benefit Analysis of Topical Tranexamic Acid in To﹣tal Hip Arthroplasty

    Institute of Scientific and Technical Information of China (English)

    谢美兆; 练伟东; 张浩; 张智勉; 郭达

    2016-01-01

    Objective To investigate the effects of topical Tranexamic Acid technique on blood loss,transfusion and cost benefit in total hip arthroplasty(THA). Methods 80 patients underwent THA from Mar 2013 to Mar 2014 were enrolled and randomly divided into Tranexamic acid group(T group,n = 40)or Control group(C group,n = 40). In T group 2. 0 g tranex-amic acid(20 mL)were prepared. 10 mL were injected peri ﹣ articularly after prosthesis was on position. 10 mL were injected intro ﹣ articularly after iliotibial band was sutured. In C group,20 mL saline were prepared,the administration was the same with T group. visible blood loss,hidden blood loss,blood transfusion per patient,24-hour postoperative red blood cell count,he-moglobin,hematocrit,3-hour postoperative prothrombin time and activated partial thromboplastin time were recorded and com-pared. Total transfusion cost,total hospitalization cost,cost per-patient,cost-benefit ratio were recorded and counted. Results Significant differences were found in visible blood loss,hidden blood loss,blood transfusion per-patient,24-hour postoperative red blood cell count,hemoglobin,hematocrit(P ﹤ 0. 05),suggesting better blood loss control in T group than C group. No sig-nificant difference in 3-hour postoperative prothrombin time and activated partial thromboplastin time(P ﹥ 0. 05). The cost of transfusion,hospitalization,per patient were lower in T group than C group. Cost-benefit ratio was 29. 164. Conclusion Topi-cal Tranexamic Acid technique in total hip arthroplasty can obviously decrease postoperative blood loss and per patient blood transfusion,and cut down the cost of hospitalization,showing good advantage in cost-benefit control.%目的:研究全髋置换术后局部应用氨甲环酸的输血及成本效益分析。方法研究选取2013年5月至2014年5月行全髋关节置换的患者80例,随机分为氨甲环酸组(T 组)40例,对照组(C 组)40例。T 组取2.0 g(20 mL)氨甲环酸,于假

  18. Genetic basis of rare blood group variants

    NARCIS (Netherlands)

    L. Wigman

    2013-01-01

    A transfusion of donor red blood cells can be life saving In individuals with massive blood loss due to an accident or surgery or in individuals with constitutive anemia due to a defect in erythropoiesis. Donor blood can, however, not be simply transfused to every patient. When a recipient of a red

  19. NARRATIVE STRUCTURES ACROSS TELLINGS OF THE SAME “GOOD” TEACHING EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Joseph Ernest Mambu

    2013-01-01

    Full Text Available Abstract: This paper investigates narrative structures of the same story told three times by an advanced male EFL (i.e., English as a foreign language learner. By narrative structures in this paper, I mean the sequence of narrative, especially in the light of the Labovian tradition of narrative analysis (Labov & Waletzky, 1997; Labov, 1972; Wu, 1995, and how each narrative component (e.g., abstract, orientation, complicating action, result/resolution, evaluation, and coda is fleshed out within and across tellings. Data analysis in this paper will attempt to answer the question of the extent to which these structures in one telling are similar or different across tellings of the same “good” experiences (cf. Chafe, 1998; Polanyi, 1981; Prior, 2011. In Labov’s (1972 data, “bad” near-death experiences were elicited, and yet a “good” result is conspicuous: death was overcome. Being asked to tell his “good” story, the EFL learner concentrated on the favorable experience. This said, some hints at unfavorable experiences—typically filling in the complicating action slot, like in telling bad or embarrassing stories (as in Wu, 1995—also emerged, which make analysis of “good” experiences worthwhile in its own right. In particular, it can be hypothesized that the underlying structure of good experiences fits into the Labovian narrative structure with some nuanced variations across tellings. The findings support the hypothesis and suggest that repeated tellings of the same story provided the speaker in this study ample room to reflect on his past experience such that subsequent tellings can be more engaging than the first (or previous telling.

  20. Blood / Money

    OpenAIRE

    Strong, Thomas

    1997-01-01

    Marilyn Strathern has argued that "nature" in Euro-American culture has appeared as constraint; it has figured the givens of existence on which human artifice is seen to construct "society" or "culture."(5) Among those givens is the notion that human beings are naturally individuals. And blood, too, images individuality: "The very thought of blood, individual blood, touches the deepest feelings in man about life and death" ([RIchard Titmuss] 16.) Transfusion medicine, then, draws on a series ...

  1. Comparison of Effects on Intravenous and Intra-Articular Cavity Injection of Tranexamic Acid on Blood Loss Volume in Total Knee Arthroplasty%氨甲环酸不同途径用药对全膝关节置换术失血量的影响

    Institute of Scientific and Technical Information of China (English)

    石永进; 王全彬; 邱庆虎

    2016-01-01

    目的:分析氨甲环酸静脉滴注与关节腔内局部注射对控制全膝关节置换手术失血量的有效性及安全性.方法:选取2012年1月—2014年10月收治的行全膝关节置换术患者73例随机分为静脉滴注组40例和腔内注射组33例,静脉组在麻醉诱导期使用氨甲环酸10 mg/kg体重,最大剂量1 g;腔内组关节囊缝合完成且止血带未放松前,将氨甲环酸1 g注入关节腔.记录两组患者术后引流量、隐性失血量、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT),观察患者是否出现下肢深静脉栓塞症状.结果:腔内组患者术后引流量(252±63)mL低于静脉组(545±61)mL,隐性失血量(603±59)mL低于静脉组(882±114)mL,差异具有统计学意义.腔内组患者PT、APTT、INR与静脉组比较差异无统计学意义(P>0.05).每组1例发生深静脉血栓.结论:关节腔内注射氨甲环酸,能有效控制全膝关节置换术后失血量,且相对安全,并不增加术后深静脉血栓发生机率.%Objective To compare the effects and operative safety of intravenous drip and intra-articular cavity local injection of tranexamic acid on controlling blood loss volume in total knee arthroplasty. Methods Totally 73 patients with total knee arthroplasty treated in the hospital from January 2012 to October 2014 were randomly divided into the intravenous drip group(IVTA)(40 cases) and the intra-articular use group(IATA) (33 cases). The patients in the control group used intravenous tranexamic acid 10 mg/kg,with the maximum dose 1.0g during the anesthetic induction period,while the patients in the treatment group were intra-articularlly injected by tranexamic acid 1g at the finishing of articular capsule suture and before relaxing the tourniquet.The postoperative blood loss,the hidden blood loss,prothrombin time (PT),activated partial thromboplastin time (APTT) were recorded for both groups. Deep-vein thrombosis (DVT) were observed. Results The postopera

  2. 50例剖腹产术中出血的临床分析与预防措施%50 Cases Clinical Analysis of Blood Loss During Caesarean Section and Preventive Measures

    Institute of Scientific and Technical Information of China (English)

    刘青建; 刘彩萍

    2013-01-01

    preventive measures.Result:In 50 cases of cesarean bleeding,11 patients due to placental factors occur in patients with bleeding,accounting for 22.0%;9 patients with coagulation disorders occur due to blood loss,accounting for 18.0%;17 cases of patients with uterine inertia occurred intraoperative bleeding,accounting for 34.0%;six cases occurred in patients with bleeding due to uterine fibroids,accounting for 12.0%,seven patients because of bleeding laceration occurred,accounting for 14.0%.Caesarean section for all patients bleeding after giving symptomatic treatment of patients with stable vital signs,no deaths.Conclusion:Placental factors,coagulation disorders,uterine inertia,uterine fibroids,bleeding laceration caesarean section is the main reason,in the clinical treatment should be based on the patient's condition,analyze the causes of bleeding,combined with medical conditions,formulate caesarean bleeding hemostasis scientific programs to ensure the safety of mother and child.

  3. Understanding Blood Counts

    Science.gov (United States)

    ... Lab and Imaging Tests Understanding Blood Counts Understanding Blood Counts Understanding Blood Counts SHARE: Print Glossary Blood cell counts give ... your blood that's occupied by red cells. Normal Blood Counts Normal blood counts fall within a range ...

  4. Different methods of tranexamic acid administration on reducing blood loss during total hip arthroplasty%不同时间给予氨甲环酸对减少全髋关节置换术中术后失血的影响

    Institute of Scientific and Technical Information of China (English)

    张朋; 陈勇忠; 杨良锁; 王剑火; 邹仪强; 黄哲

    2014-01-01

    目的:比较氨甲环酸不同给药时间对全髋关节置换( THA)术中及术后失血量的影响。方法选取行单侧THA的患者125例,随机分为5组,每组25例,A组手术结束前10 min给予1 g氨甲环酸静脉滴注;B组分别于手术结束前10 min、术后7 h给予1 g氨甲环酸静脉滴注;C组术前10 min给予1 g氨甲环酸静脉滴注;D组术前10 min给予1 g氨甲环酸,7 h后再给予1 g氨甲环酸静脉滴注;E组为对照组,不给于氨甲环酸及其类似药物。检测血红蛋白、红细胞压积、出血时间、活化部分凝血酶时间等血液学指标,比较5组患者术中及术后失血量差异。结果5组患者术中失血量、术后失血量、术后第1天血红蛋白下降值、围手术期最大血红蛋白减少值、术后绝对失血量差异均具有统计学意义(P<0.05)。 E组5项数值均显著高于其它各组(P<0.05)。 D组术中失血量、围手术期最大血红蛋白减少值、术后绝对失血量分别为(272.9±46.7)ml、(27.8±3.8)g/L、(344.4±61.6)ml,均显著少(小)于A组、B组及E组(P<0.05)。 C组术后失血量、术后第1天血红蛋白下降值,分别为(114.7±32.7)ml、(21.0±3.9)g/L,均显著少(小)于A组、B组及E组(P<0.05)。结论术前10 min给予1 g氨甲环酸,7 h后再给予1 g氨甲环酸静脉滴注在THA围手术期能够最大限度地减少术中及术后出血量。%Objective To compare the different timing of administration of tranexamic acid on total hip arthroplasty and postoperative blood loss. Methods 125 cases undergo total hip arthroplasty were randomly divided into five groups, 25 cases each. Patients in group A received 1g tranexamic acid intravenously 10min before the end of surger-y, group B received 1g tranexamic acid intravenously 10 min before the end of surgery and again in 7 hours after sur-gery, group C received 1g tranexamic acid intravenously 10 min before surgery, group D received 1g tranexamic acid 10 min before surgery and

  5. Blood donation

    CERN Multimedia

    GS Department

    2009-01-01

    A blood donation is organised by the Cantonal Hospital of Geneva On Thursday 19 March 2009 from 9 a.m. to 5 p.m. CERN RESTAURANT 2 Number of donations during the last blood donations :135 donors in July 2008 122 donors in November 2008 Let’s do better in 2009 !!! Give 30 minutes of your time to save lives...

  6. BLOOD DONATION

    CERN Document Server

    SC Unit

    2008-01-01

    A blood donation, organized by EFS (Etablissement Français du Sang) of Annemasse will take place On Wednesday 12 November 2008, from 8:30 to 16:00, at CERN Restaurant 2 If possible, please, bring your blood group Card.

  7. Tainted blood

    DEFF Research Database (Denmark)

    Deleuran, Ida; Sheikh, Zainab Afshan; Hoeyer, Klaus

    2015-01-01

    study of the historical rise and current workings of safety practices in the Danish blood system. Here, we identify a strong focus on contamination in order to avoid 'tainted blood', at the expense of working with risks that could be avoided through enhanced blood monitoring practices. Of further...... significance to this focus are the social dynamics found at the heart of safety practices aimed at avoiding contamination. We argue that such dynamics need more attention, in order to achieve good health outcomes in transfusion medicine. Thus, we conclude that, to ensure continuously safe blood systems, we...... need to move beyond the bifurcation of the social and medical aspects of blood supply as two separate issues and approach social dynamics as key medical safety questions....

  8. Doctors May Not Be Telling High-Risk Patients about HIV Prevention Drug

    Science.gov (United States)

    ... news/fullstory_161405.html Doctors May Not Be Telling High-Risk Patients About HIV Prevention Drug Less ... Copyright (c) 2016 HealthDay . All rights reserved. News stories are provided by HealthDay and do not reflect ...

  9. Estradiol blood test

    Science.gov (United States)

    E2 test ... temporarily stop taking certain medicines that may affect test results. Be sure to tell your provider about ... helps prevent sperm from dying too early. This test may be ordered to check: How well your ...

  10. AMIDST: Attracting Minorities to Geosciences Through Involved Digital Story Telling

    Science.gov (United States)

    Prakash, A.; Ohler, J.; Cooper, C.; McDermott, M.; Heinrich, J.; Johnson, R.; Leeper, L.; Polk, N.; Wimer, T.

    2009-12-01

    Attracting Minorities to Geosciences Through Involved Digital Story Telling (AMIDST) is a project funded by the Geoscience Directorate of the National Science Foundation through their program entitled Opportunities for Enhancing Diversity in Geosciences. This project centers around the idea of integrating place-based geoscience education with culturally sensitive digital story telling, to engage and attract Alaska’s native and rural children from grades 3 through 5 to geosciences. In Spring 2008 we brought together a team 2 native elders, a group of scientists and technicians, an evaluator, 2 teachers and their 24 third grade students from Fairbanks (interior Alaska) to create computer-based digital stories around the geoscience themes of permafrost, and forest fires. These two to four minutes digital narratives consisted of a series of images accompanied by music and a voice-over narration by the children. In Fall 2008 we worked with a similar group from Nome (coastal town in western Alaska). The geoscience themes were climate change, and gold in Alaska. This time the students used the same kind of “green screen” editing so prevalent in science fiction movies. Students enacted and recorded their stories in front of a green screen and in post-production replaced the green background with photos, drawings and scientific illustrations related to their stories. Evaluation involved pre and post project tests for all participants, mid-term individual interviews and exit-interviews of selected participants. Project final assessment results from an independent education evaluator showed that both students and teachers improved their geo science content knowledge about permafrost, forest fires, gold mining, and sea ice changes. Teachers and students went through a very steep learning curve and gained experience and new understanding in digital storytelling in the context of geologic phenomena of local interest. Children took pride in being creators, directors and

  11. Telling the truth: what do general practitioners say to patients with dementia or terminal cancer?

    OpenAIRE

    Vassilas, C A; Donaldson, J

    1998-01-01

    A questionnaire was sent to all general practitioners (GPs) in Cambridgeshire asking them about their practice in telling patients with dementia or terminal cancer their diagnosis. Although the majority of GPs would always or often tell patients of a diagnosis of terminal cancer, this was not the case in dementia; uncertainty of diagnosis was cited as the most important factor in not giving the diagnosis. The implications of these findings are discussed in the light of the GP's role in dement...

  12. Transitional Justice: History-Telling, Collective Memory, and the Victim-Witness

    OpenAIRE

    Chrisje Brants; Katrien Klep

    2013-01-01

    This article examines the complex, inherently political, and often contradictory processes of truth-finding, history-telling, and formation of collective memory through transitional justice. It explores tensions between history-telling and the normative goals of truth commissions and international criminal courts, taking into account the increasing importance attributed to victims as witnesses of history. The legal space these instruments of transitional justice offer is determined b...

  13. Efficacy and safety of tranexamic acid on perioperative blood loss in total knee arthroplasty%氨甲环酸对全膝关节置换术围手术期失血量的影响及安全性评估

    Institute of Scientific and Technical Information of China (English)

    苗兵; 毕晓扬; 任凯晶; 于建华

    2009-01-01

    Objective To investigate the efficacy and safety of tranexamic aeid on perioperative blood loss associated with total knee arthroplasty(TKA). Methods From May 2008 to February 2009, 98 pa-tients (35 males, 63 females) underwent TKA, 66 cases with osteoarthritis, 32 with rheumatoid arthritis. The course of illness ranged from 2 to 12 years (mean, 5 years). They were randomly divided into Group A and B with 49 patients each. The patients in Group A received tranexamic acid, and the patients in Group B re-ceived an equal volume of normal saline, in Group A, 1 g of tranexamic acid dissolved in 250 ml of normal saline was intravenously infused before deflation of the tourniquet; another intravenous administration of the same drug of the same dosage was given 3 h later. In Group B, only 250 ml of normal saline was infused in-travenously. The amounts of intraoperative blood loss, postoperative wound blood loss and blood transfusion,the number of the patients needing blood transfusion and the value of postoperative hemoglobin concentration of all patients were recorded. Fibrinogen, prothrombin time, and activated partial thromboplastin time were also examined before operation, during operation (deflation of the tourniquet), and 3 hours after operation.And they were also observed for whether they had deep vein thrombosis and both lower limbs of all patients were examined by the color Doppler uhrasonography 14 days after operation. Results There was no signifi-cant difference in intraoperative blood loss botween two groups(P >0.05). There were significant differences in the amount of postoperative wound blood loss, blood transfusion, the number of the patients needing blood transfusion and the value of postoperative hemoglobin concentration between two groups, Group A were lower than Group B (P0.05). And no deep vein thrombosis was found 14 days after operation. Conclusion During and after the TKA, a short-term use of tranexamic acid can significantly decrease blood loss and

  14. Bringing it all Back Home: the Practical Visual Environments of Southeast European Tells

    Directory of Open Access Journals (Sweden)

    Steven Trick

    2004-11-01

    Full Text Available This article attempts to further our understanding of tells in southeast Europe by considering their landscape context, where the research methodology comprises an innovative hybrid of modern landscape theory, and GIS-based visual analysis. Tell landscapes are explored through the detailed analysis of a group of case study tells located in the Romanian Plain, in southern Romania, dating to the fifth millennium BC. A visual, so-called phenomenological approach is adopted, but novel to this paradigm is the use of GIS as the prime tool with which to conduct visual research. GIS offers a convenient means to visualise and quantify visual parameters of landscape, but its formal nature also brings some rigour to phenomenological research, which has been criticised for lack of standard method. Viewshed tools are utilised in standard form, but also in enriched ‘Higuchi’ and ‘Directional’ forms. The temporal nature of tell settlements is explored through the generation of viewshed maps from different cultural levels of the mound. Results of the analysis are presented and common patterns in the dataset identified. Taking inspiration from the Heideggarian notion of dwelling, a generalised interpretive framework is forwarded. It is suggested that tells were located with respect to visual entities in the environment, and that the nature of the visibility tells us something of the lives of people dwelling on and around them. The article is derived from a lecture given at the Theoretical Archaeology Group conference, Manchester, December 2002.

  15. Showing and telling: using tablet technology to engage students in mathematics

    Science.gov (United States)

    Ingram, Naomi; Williamson-Leadley, Sandra; Pratt, Keryn

    2016-03-01

    This paper reports on a qualitative investigation into the use of Show and Tell tablet technology in mathematics classrooms. A Show and Tell application (app) allows the user to capture voice and writing or text in real time. Described here are the perceptions of 11 teachers during and after their exploration into the use of Show and Tell in their primary and secondary classrooms. These perceptions were used to evaluate Show and Tell tablet technology against a framework of student engagement and effective pedagogy. The results of the study indicated that the teachers perceived both the level and the quality of the students' engagement were high. Using Show and Tell apps enabled the teachers to enact effective pedagogy within their classroom practices. Importantly, through the use of Show and Tell recordings, students' thinking became visible to themselves, their teachers and other students in the class. This thinking then formed the basis of robust discussions and negotiation about the mathematical concepts and the strategies the students used to solve problems.

  16. What does global mean temperature tell us about local climate?

    Science.gov (United States)

    Sutton, Rowan; Suckling, Emma; Hawkins, Ed

    2015-11-13

    The subject of climate feedbacks focuses attention on global mean surface air temperature (GMST) as the key metric of climate change. But what does knowledge of past and future GMST tell us about the climate of specific regions? In the context of the ongoing UNFCCC process, this is an important question for policy-makers as well as for scientists. The answer depends on many factors, including the mechanisms causing changes, the timescale of the changes, and the variables and regions of interest. This paper provides a review and analysis of the relationship between changes in GMST and changes in local climate, first in observational records and then in a range of climate model simulations, which are used to interpret the observations. The focus is on decadal timescales, which are of particular interest in relation to recent and near-future anthropogenic climate change. It is shown that GMST primarily provides information about forced responses, but that understanding and quantifying internal variability is essential to projecting climate and climate impacts on regional-to-local scales. The relationship between local forced responses and GMST is often linear but may be nonlinear, and can be greatly complicated by competition between different forcing factors. Climate projections are limited not only by uncertainties in the signal of climate change but also by uncertainties in the characteristics of real-world internal variability. Finally, it is shown that the relationship between GMST and local climate provides a simple approach to climate change detection, and a useful guide to attribution studies.

  17. Truth Telling, Companionship, and Witness: An Agenda for Narrative Ethics.

    Science.gov (United States)

    Frank, Arthur W

    2016-05-01

    Narrative ethics holds that if you ask someone what goodness is, as a basis of action, most people will first appeal to various abstractions, each of which can be defined only by other abstractions that in turn require further definition. If you persist in asking what each of these abstractions actually means, eventually that person will have to tell you a story and expect you to recognize goodness in the story. Goodness and badness need stories to make them thinkable and to translate them into individual and collective actions. Yet after more than two decades of considering the issue, I do not believe that a collection of stories can by itself guide actions in ways that are sufficient to respond to ethical troubles in institutional settings. The question will always remain open for me, but my present belief is that narrative bioethics is always hyphenated, in the sense that guidance from stories needs to be allied with other ethical guidance. Each side of the hyphen qualifies the other side. The hyphenation I will argue for in this essay is "narrative-deontology."

  18. What can causal networks tell us about metabolic pathways?

    Directory of Open Access Journals (Sweden)

    Rachael Hageman Blair

    Full Text Available Graphical models describe the linear correlation structure of data and have been used to establish causal relationships among phenotypes in genetic mapping populations. Data are typically collected at a single point in time. Biological processes on the other hand are often non-linear and display time varying dynamics. The extent to which graphical models can recapitulate the architecture of an underlying biological processes is not well understood. We consider metabolic networks with known stoichiometry to address the fundamental question: "What can causal networks tell us about metabolic pathways?". Using data from an Arabidopsis Bay[Formula: see text]Sha population and simulated data from dynamic models of pathway motifs, we assess our ability to reconstruct metabolic pathways using graphical models. Our results highlight the necessity of non-genetic residual biological variation for reliable inference. Recovery of the ordering within a pathway is possible, but should not be expected. Causal inference is sensitive to subtle patterns in the correlation structure that may be driven by a variety of factors, which may not emphasize the substrate-product relationship. We illustrate the effects of metabolic pathway architecture, epistasis and stochastic variation on correlation structure and graphical model-derived networks. We conclude that graphical models should be interpreted cautiously, especially if the implied causal relationships are to be used in the design of intervention strategies.

  19. What Gay-Lussac didn't tell us

    Science.gov (United States)

    Holbrow, C. H.; Amato, J. C.

    2011-01-01

    Gay-Lussac's 1801 experiments establishing the law of volumes for gases are brilliantly simple, and he described them with a level of detail that was new to physics writing. But he did not present his actual measurements or tell us how he analyzed them to conclude that between 0 to 100 °C, a volume of any gas will expand by about 37.5%. We review his experiments and conclude that he measured initial and final volumes at slightly different pressures. By using the gas laws and his apparatus diagrams, we corrected his data so that they correspond to constant pressure. His corrected results give ΔV/V=36.6%, the currently accepted value for nearly ideal gases. Aside from their intrinsic interest, our analyses can provide students intriguing applications of the gas laws and Pascal's law and motivate them to consider Pascal's paradox. We also note the influence of ballooning and of the French Revolution on Gay-Lussac.

  20. Truth Telling, Companionship, and Witness: An Agenda for Narrative Ethics.

    Science.gov (United States)

    Frank, Arthur W

    2016-05-01

    Narrative ethics holds that if you ask someone what goodness is, as a basis of action, most people will first appeal to various abstractions, each of which can be defined only by other abstractions that in turn require further definition. If you persist in asking what each of these abstractions actually means, eventually that person will have to tell you a story and expect you to recognize goodness in the story. Goodness and badness need stories to make them thinkable and to translate them into individual and collective actions. Yet after more than two decades of considering the issue, I do not believe that a collection of stories can by itself guide actions in ways that are sufficient to respond to ethical troubles in institutional settings. The question will always remain open for me, but my present belief is that narrative bioethics is always hyphenated, in the sense that guidance from stories needs to be allied with other ethical guidance. Each side of the hyphen qualifies the other side. The hyphenation I will argue for in this essay is "narrative-deontology." PMID:27150414

  1. Vision Loss, Sudden

    Science.gov (United States)

    ... of age-related macular degeneration. Spotlight on Aging: Vision Loss in Older People Most commonly, vision loss ... Some Causes and Features of Sudden Loss of Vision Cause Common Features* Tests Sudden loss of vision ...

  2. A paródia da autobiografia em Lygia Fagundes Telles = A parody of autobiographies in Lygia Fagundes Telles

    Directory of Open Access Journals (Sweden)

    Carlos Magno Santos Gomes

    2008-01-01

    Full Text Available Este artigo defende a hipótese de que o romance As horas nuas (1989, de Lygia Fagundes Telles, apresenta um sofisticado jogo auto-referencial da obra dentro da obra. As cenas em que Rosa, a protagonista, tenta escrever suas memórias, mas é consumida peloalcoolismo, fortalecem as idéias de paródia e de descentramento estético, presentes nesse romance. Rosa narra e comenta a superficialidade de suas memórias até abandonar seu projeto de escrita, que pode ser lido como uma paródia das autobiografias. Essa hipótese será sustentada metodologicamente pelos conceitos pós-estruturalistas propostos por Jacques Derrida, que defende a escrita como jogo, remédio, veneno ou teatro, entre outrosconceitos. A partir dos suplementos estéticos da encenação de Rosa, o leitor, preocupado com o “como” a obra foi construída, descobre novos roteiros desse romance que se autoquestiona no próprio desenrolar da narrativa. Ao final, interpreta-se o silêncio de Rosa como uma crítica à superficialidade e ao narcisismo do gênero autobiográfico.This study defends the idea that the novel As horas nuas (1989, by Lygia Fagundes Telles, presents a sophisticated auto-referential game concerning the artistic production in itself. The scenes in which Rosa, the main character, tries to write her memories, but is absorbed by alcoholism, strengths the idea of parody and esthetic disorder in this novel. Rosa narrates and comments the superficiality of her memories until the moment that she abandons herwriting project, which can be read as a parody of autobiographies. This hypothesis is supported methodologically by the post-structuralism concepts proposed by Jacques Derrida, which defends the writing as a game, medicine, poison or theater, beyond other concepts. Using the esthetic supplements of Rosa’s staging, which narrates her memories to a recorder, the reader concerned about “how” the novel was built discovers new scripts of the novel that provokes

  3. Blood loss and limb circumference changes in patients undergoing unilateral total knee arthroplasty after intra-articular injection of tranexamic acid:a randomized controlled trial%关节腔注射氨甲环酸单侧全膝关节置换者的失血量及肢体周径变化:随机对照

    Institute of Scientific and Technical Information of China (English)

    马金辉; 孙伟; 高福强; 王云亭; 李子荣

    2014-01-01

    BACKGROUND:Tranexamic acid has been more and more used in reducing bleeding after joint replacement, but its usage method and dosage remain controversial, and become a hot focus in recent years. OBJECTIVE:To investigate the efficacy of intra-articular injection of tranexamic acid on postoperative blood loss and limb circumference changes in patients who received unilateral total knee arthroplasty. METHODS:From March to October 2013, clinical data of 90 patients undergoing primary unilateral total knee arthroplasty were randomized to the tranexamic acid group and the control group, including 19 males and 71 females. The 30 patients in the tranexamic acid group received 50 mL of 3%tranexamic acid dilute solution inside knee joint after capsule closure, and 60 patients in the control group received the same volume of physiological saline. No significant difference in age, height, body mass index, anticoagulation, the type of prosthesis, tourniquet time and preoperative diagnosis was detected between the two groups (P>0.05). The amounts of intraoperative and postoperative blood loss and blood transfusion, postoperative drainage volume, the preoperative and postoperative limb circumference 10 cm above the operated knee were recorded. Routine blood test was reviewed after the surgery. RESULTS AND CONCLUSION:There were no significant differences in total blood loss, postoperative drainage volume and limb circumference changes between tranexamic acid and control groups (P>0.05). The amount of postoperative hidden blood loss was significantly less in the tranexamic acid group than in the control group (t=-2.683, P0.05)。记录患者术中及术后失血量和输血量、术后第1天引流量,测量术前及术后术侧膝上10 cm肢体周径,术后连续复查血常规。结果与结论:氨甲环酸组和对照组手术总失血量、术后第1天引流量与术侧肢体周径变化情况比较差异均无显著性意义(P>0.05),术后隐性失

  4. Efficacy and safety of single preoperative dose tranexamic acid use for perioperative blood loss control in patients having primary total hip arthroplasty%术前单一剂量氨甲环酸对初次全髋关节置换术围手术期失血的影响及安全性评估

    Institute of Scientific and Technical Information of China (English)

    张弛; 乔志; 刘宏建; 殷力; 张宜远; 王义生

    2014-01-01

    目的 探讨使用氨甲环酸是否能够安全、有效地减少全髋关节置换术围手术期的出血量和输血率.方法 将100例行全髋关节置换术患者随机平均分为两组,氨甲环酸组于切皮前15 min将氨甲环酸按20 mg/kg单一剂量静脉输注,对照组同时间点给予等量生理盐水.对比术后2d的血红蛋白减少量、输血量、输血人数和术后静脉血栓形成风险的差异.结果 氨甲环酸组患者血红蛋白减少量、输血量和输血人数分别为(44.3±13.2) g/L、(338.8 ±92.7) ml、13例(26%),低于对照组的(53.4±8.9) g/L、(459.7±188.5)ml、29例(58%,P<0.05);两组患者术后深静脉血栓发生率差异无统计学意义(P>0.05).结论 氨甲环酸能够减少全髋关节置换术患者围手术期的出血量和输血率,不增加术后血栓形成的风险.%Objective To investigate the efficacy and safety of single preoperative dose tranexamic acid use for perioperative blood loss control in patients having primary total hip arthroplasty.Methods One hundred patients having primary total hip arthroplasty were randomly divided into 2 groups,the tranexamic acid group and the control group,with 50 patients in each.In the tranexamic acid group,a single dose of 20 mg/kg was infused intravenously within 15 minutes before skin incision,while an equal volume of normal saline was given instead in the control group.Hemoglobin losses,blood transfusion volume and blood transfusion rate of these two groups were measured before and two days after operation,the comparative analysis was conducted.Deep vein thrombosis was also observed in these two groups.Results Hemoglobin losses,blood transfusion volume and blood transfusion rate in the tranexamic acid group were (44.3 ± 13.2) g/L,(338.8 ±92.7) ml,13 (26%),lower than the control group (53.4 ± 8.9) g/L,(459.7 ± 188.5) ml,29 (58%) (P < 0.05); while no significant difference was detected in the incidence of venous thrombosis (P > 0

  5. Moving blood.

    Science.gov (United States)

    Pelis, K

    1997-01-01

    Our internationally acclaimed journalist Sanguinia has returned safely from her historic assignment. Travelling from Homeric Greece to British Romanticism, she was witness to blood drinking, letting, bathing, and transfusion. In this report, she explores connections between the symbolic and the sadistic; the mythic and the medical--all in an effort to appreciate the layered meanings our culture has given to the movement of blood between our bodies. PMID:9407636

  6. Older Adults and Smell Loss

    Medline Plus

    Full Text Available ... it serves two main functions. It tells us what is in the environment and it warns us ... think they have a problem with taste, when what they really have is a problem with smell. ...

  7. Older Adults and Smell Loss

    Medline Plus

    Full Text Available ... beverages or the scents and fragrances in our environment. More importantly, we would be deprived of an ... functions. It tells us what is in the environment and it warns us of dangers, such as ...

  8. Older Adults and Smell Loss

    Medline Plus

    Full Text Available ... Our sense of smell is very important. Without it, we would not be able to enjoy food ... Beauchamp: he sense of smell is important because it serves two main functions. It tells us what ...

  9. Biology of Blood

    Science.gov (United States)

    ... Mail Facebook TwitterTitle Google+ LinkedIn Home Blood Disorders Biology of Blood Overview of Blood Medical Dictionary Also ... Version. DOCTORS: Click here for the Professional Version Biology of Blood Overview of Blood Components of Blood ...

  10. Blood donation before surgery

    Science.gov (United States)

    ... type of donor blood. Many communities have a blood bank where healthy people can donate blood. This blood ... need to arrange with your hospital or local blood bank before your surgery to have directed donor blood. ...

  11. Blood Clotting and Pregnancy

    Medline Plus

    Full Text Available ... Blood Basics Blood Disorders Anemia Bleeding Disorders Blood Cancers Blood Clots Blood Clotting and Pregnancy Clots and ... Increased maternal age Other medical illness (e.g., cancer, infection) back to top How are Blood Clots ...

  12. Catecholamine blood test

    Science.gov (United States)

    Norepinephrine -- blood; Epinephrine -- blood; Adrenalin -- blood; Dopamine -- blood ... A blood sample is needed. ... the test. This is especially true if both blood and urine catecholamines are to be measured. You ...

  13. Blood (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Blood KidsHealth > For Parents > Blood Print A A A ... about the mysterious, life-sustaining fluid called blood. Blood Basics Two types of blood vessels carry blood ...

  14. Blood Facts and Statistics

    Science.gov (United States)

    ... About Blood > Blood Facts and Statistics Printable Version Blood Facts and Statistics Facts about blood needs Facts ... about American Red Cross Blood Services Facts about blood needs Every two seconds someone in the U.S. ...

  15. Managing your blood sugar

    Science.gov (United States)

    Hyperglycemia - control; Hypoglycemia - control; Diabetes - blood sugar control; Blood glucose - managing ... Know how to: Recognize and treat low blood sugar (hypoglycemia) Recognize and treat high blood sugar (hyperglycemia) ...

  16. USArray Siting Outreach: Telling the EarthScope Story

    Science.gov (United States)

    Dorr, P. M.; Taber, J. J.; McQuillan, P.; Busby, R. W.; Woodward, R.

    2013-12-01

    USArray has engaged in a variety of activities that involve students in and inform the general public about EarthScope. Examples include the highly successful Transportable Array Student Siting Program that employed students and faculty from colleges and universities in the identification of sites for future Transportable Array stations in their region, and a range of informal education and media opportunities where information about EarthScope and its discoveries are shared with educators and the public. During the course of eight summers, more than 135 students from about 55 institutions conducted site reconnaissance for nearly 1375 sites from the West Coast to the East Coast, and from the Gulf of Mexico to the Great Lakes and southern Canada. While telling the EarthScope story, students who participated in the program increased their professional skills and deepened their personal growth. Other students had opportunities to engage in EarthScope-related research as part of the Research Experiences for Undergraduates program. Several EarthScope-focused outreach products for the public and educational audiences have been developed including Ground Motion Visualizations, EarthScope-centric and regional content sets for the IRIS Active Earth Monitor (AEM), and animations of earth processes. A kiosk loan program has helped to broadly disseminate the AEM displays. There have also been articles published in university, local and regional newspapers; stories appearing in national and international print and broadcast media; and documentaries produced by some of the world's most respected scientific and educational production companies that have included a segment about EarthScope and the Transportable Array. Over the next five years, USArray will be deploying and operating Transportable Array stations in Alaska and western Canada. This challenging environment will offer new opportunities to connect with communities throughout the region including native populations.

  17. What Can Sounds Tell Us About Earthquake Interactions?

    Science.gov (United States)

    Aiken, C.; Peng, Z.

    2012-12-01

    interactions can tell us about the source characteristics of earthquakes and tremors.

  18. Tranexamic Acid and Oxytocin in the Reduction of Perioperative Blood Loss for Myomectomy: Randomized Controlled Trial%氨甲环酸联合缩宫素减少子宫肌瘤剔除术围手术期出血的随机对照研究

    Institute of Scientific and Technical Information of China (English)

    王琦; 赵菊美; 程静

    2012-01-01

    目的 探讨联合应用氨甲环酸和缩宫素对降低子宫肌瘤剔除术围手术期出血量的有效性和安全性.方法 选择2008年1月至2010年12月于本院拟行经腹子宫肌瘤剔除术后的患者150例为研究对象.将其按照人院顺序随机纳入A组(n=50,静脉滴注氨甲环酸+缩宫素止血治疗),B组(n=50,静脉滴注缩宫素止血治疗)和C组(n=50,静脉滴注氨甲环酸止血治疗).围手术期止血措施采取双盲法进行,除研究设计者外,受试对象本人与研究实施者对具体措施均不知晓(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书).对3种子宫肌瘤剔除术围手术期止血效果[术中及术后出血量、术后输血率、术后血红蛋白(Hb)水平]进行统计学分析.结果 本研究4例受试对象因术中发现子宫肌瘤剔除术困难而改行子宫次全切除术.因此,A,B及C组实际纳入患者分别为49例,48例及49例.3组患者一般临床资料比较,差异无统计学意义(P>0.05).所有患者对上述围手术期的止血措施均无明显不良反应.A组术中出血量[(257±180)mL]明显低于B组[(490±368) mL]和C组[(538±352) mL],组间比较,差异有统计学意义(P<0.001);而B组和C组术中出血量比较,差异无统计学意义(P=0.513).3组间术后出血量、术后Hb水平和输血率比较,差异无统计学意义(P>0.05).结论 氨甲环酸联合缩宫素可有效降低子宫肌瘤剔除术的术中出血量,并且明显优于二者单独应用.单独使用氨甲环酸或缩宫素对子宫肌瘤剔除术围手术期的止血效果相当.%Objective To investigate the effect and safety of tranexamic acid and oxytocin in perioperative blood loss for women underwent myomectomy.Methods From January 2008 to December 2010,a total of 150 patients who underwent open surgery of myomectomy were

  19. Research of affection for blood loss in different ways to use tranexamic acid in total hip arthroplasty%氨甲环酸的使用方式对全髋置换术显隐性失血影响的研究

    Institute of Scientific and Technical Information of China (English)

    王剑; 谢飞; 刘先齐; 赵建军; 李茂生; 冷通国; 林洪伟

    2015-01-01

    目的:通过分组对照实验,探讨氨甲环酸的不同使用方式对全髋关节置换术(THA)显隐性失血的影响。方法病例选自该院骨科2010年3月至2013年8月共60例患者。诊断:股骨颈骨折47例,股骨头坏死13例;年龄45~82岁,平均62岁,均接受单侧T H A。所有病例分为A组、B组和C组共3组,各20例,经过筛选,每组男性6例,女性14例,均为初次全髋置换。A组术前0.5 h、术后3 h分别予100 mL生理盐水静滴;B组术前0.5 h将氨甲环酸按10 mg/kg稀释于100 mL生理盐水中静滴,术后3 h予100 mL生理盐水静滴;C组术前0.5 h、术后3 h分别将氨甲环酸按10 mg/kg稀释于100 mL生理盐水中静滴。计算各组患者的显性及隐性失血量,并进行统计学分析,探讨实验组中氨甲环酸2种使用方式的有效性及安全性。结果显性红细胞丢失量:A组(196.20±44.45)m L ,B组(114.84±35.21)m L ,C组(104.47±30.01)m L ;隐性红细胞丢失量:A组(614.50±98.41)m L ,B组(425.74±70.01)m L ,C组(337.12±52.23)m L。结论氨甲环酸的使用能明显减少T H A的显隐性失血量,术前0.5h合并术后3h使用较术前0.5h使用对减少隐性失血量效果更佳,进一步减少输血量,且不会明显增加下肢深静脉血栓形成的发生率。%Objective To explore the influence of tranexamic acid used in different modes in total hip arthroplasty (T HA ) blood loss by control experiment .Methods 60 patients accepted total hip arthroplasty from orthopaedics in our hospital were se‐lected between March 2010 to August 2013 ,among them femoral neck fracture were 47 cases and 13 cases were osteonecrosis .aged between 45‐82 years old ,and 62 in average .All gave unilateral total hip arthroplasty .All patients were divided into three groups ,A group(contradistinction group) ,B ,C group(experiment group) .each groups include 6 men

  20. Effects of intraarticular tranexamic acid injection combined with 3-hour drainage tube occlusion postoperatively on blood loss in unicompartmental knee arthroplasty%氨甲环酸关节腔内注射联合置换后3 h夹闭引流管对膝关节单髁置换失血量的影响

    Institute of Scientific and Technical Information of China (English)

    曾兵; 刘刚; 贺志盛; 郑连杰; 荆丰博; 吕浩

    2016-01-01

    BACKGROUND:Unicompartmental knee arthroplasty has become mainstream operation for treatment of unicompartmental osteoarthritis of the knee, but unicompartmental knee arthroplastystil has some problems, such as excessive bleeding-induced postoperative blood transfusion, increased blood transfusion rate, hospitalization expense and complication of blood transfusion. As tranexamic acid for total knee arthroplasty has achieved good effects. It is significant to investigate whether local application of tranexamic acid can effectively reduce blood loss in unicompartmental arthroplasty. OBJECTIVE:To investigate the efficacy and safety of the intra-articular tranexamic acid injection in treating perioperative blood loss in patients undergoing unicompartmental knee arthroplasty. METHODS:122 patients with knee osteoarthritis undergoing unicompartmental knee arthroplastyinthe Department of Orthopedics, the Second Affiliated Hospital ofDalian Medical University from January 2014 to August 2015wereenroled in this study. Al patients were randomly divided into two groups. Patients in the tranexamic acid group were injected with 10 mL of tranexamic acid (containing 1000 mg) + 10 mL of sodium chloride injection in the articular cavity before loosening the tourniquet. Patients in the control group received 20 mL of sodium chloride injection in the articular cavity. In both groups, the drainage tube was clipped for 3 hours after injection.At 48 hours after replacement, the drainage tube was puled out. We compared and analyzed hemoglobin levels and hematocrit at 2 days and 1 month postoperatively, total blood loss and drainage volume at 2 days postoperatively, the number of patients receiving blood transfusion, Hospital for Special Surgery scores of knee function at 1 week and 1 month postoperatively, and thrombosis at 1 week postoperatively, and evaluated effects of tranexamic acid on blood loss after unicompartmental knee arthroplasty. RESULTS AND CONCLUSION:(1) Hemoglobin levels

  1. Weight-loss surgery - before - what to ask your doctor

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    ... your doctor; What to ask your doctor before weight-loss surgery ... What are the reasons someone should have weight-loss surgery? Why is weight-loss surgery not a good choice for everyone who is overweight or obese? What is diabetes ? High blood pressure ? ...

  2. Balancing truth-telling in the preservation of hope: a relational ethics approach.

    Science.gov (United States)

    Pergert, Pernilla; Lützén, Kim

    2012-01-01

    Truth-telling in healthcare practice can be regarded as a universal communicative virtue; however, there are different views on what consequence it has for giving or diminishing hope. The aim of this article is to explore the relationship between the concepts of truth-telling and hope from a relational ethics approach in the context of healthcare practice. Healthcare staff protect themselves and others to preserve hope in the care of seriously sick patients and in end-of-life care. This is done by balancing truth-telling guided by different conditions such as the cultural norms of patients, family and staff. Our main conclusion is that the balancing of truth-telling needs to be decided in a mutual understanding in the caring relationship, but hope must always be inspired. Instead of focusing on autonomy as the only guiding principle, we would like to propose that relational ethics can serve as a meaningful perspective in balancing truth-telling. PMID:22140184

  3. Blood Transfusion

    Science.gov (United States)

    ... to infections including those we develop from our vaccinations (such as poliovirus antibodies, which are made by ... the Transfusion Medicine Unit, Blood Bank, and Stem Cell Storage Facility University of Rochester Medical ... and health educators who are available by phone Monday through Friday, 9 am to 9 pm ( ...

  4. Living with vision loss

    Science.gov (United States)

    Diabetes - vision loss; Retinopathy - vision loss; Low vision; Blindness - vision loss ... Low vision is a visual disability. Wearing regular glasses or contacts does not help. People with low vision have ...

  5. What Pacific tsunamis tell us about underestimating hazard and risk

    Science.gov (United States)

    Goff, J. R.

    2011-12-01

    "The one thing we learn from history is that we learn nothing from history". As we move further in to the 21st Century, Benjamin Disraeli's words resonate strongly for many of us involved in disaster risk reduction. From tsunami research in the Pacific region perhaps a more appropriate quote would read "The one thing we learn from history is that we learn nothing from prehistory". We rely a lot on what history tells us, which in reality is what was and is written down and how we decide to interpret and use this information. Stepping outside this "comfort zone" takes many into unfamiliar territory and others into familiar ground - that of prehistory. Both history and prehistory have their uses in tsunami research, uses that are actually more powerful when combined. However, when studying prehistory we must recognise that we have no specific reference point in time to which we can anchor a disparate dataset of information. This by no means diminishes the importance of the data, it just makes it different. Catastrophic events in prehistory are not recognised because they happened on a certain day at a certain time, but because they left behind markers of their catastrophic nature, indicators that can vary from local, to regional, to global effects that occurred "around about the same time". The dating is never as precise as an historical event, but the data are no less significant. To gauge the full extent of prehistoric events such as tsunamis we must draw on a toolkit that includes not only earth science (geology and geomorphology) but also archaeology, anthropology and palaeoecology, and many more. This by no means dilutes the significance of any one of the disciplines, but rather adds value to each. For example, Western science and Traditional Environmental Knowledge (TEK) are two sides of the same coin. We ignore each other at our peril. The study of palaeotsunamis in the Pacific is in its infancy, but that should not diminish the message. Larger events have

  6. 关节内注射氨甲环酸减少全膝关节置换术后失血的临床分析%Clinical study on intra-articular injection of tranexamic acid to reduce blood loss in total knee replacement

    Institute of Scientific and Technical Information of China (English)

    彭伟

    2014-01-01

    目的:探讨关节内注射氨甲环酸对人工全膝关节置换术后失血的影响。方法将50例采取单侧初次人工全膝关节置换患者,随机分为治疗组25例和对照组25例。治疗组采用关节腔内注射氨甲环酸1000 mg,术后夹闭引流2 h,对照组采用生理盐水。术后记录术中失血量、术后引流量、血红蛋白( Hb)、红细胞压积( Hct)和输血例数、D-二聚体改变以及深静脉血栓发生例数。结果治疗组术后引流量、输血例数和D-二聚体值显著低于对照组(P<0.05);治疗组血红蛋白、红细胞压积显著高于对照组(P<0.05);2组均无深静脉血栓形成。结论人工全膝关节置换术后关节腔内注射氨甲环酸并夹闭引流2 h的方法能够有效减少术后失血量,同时不增加深静脉血栓发生率。%Objective To examine the influence of inra-articular injection of tranexamic acid on blood loss after total knee replacement. Methods 50 patients with unilateral primary total knee replacement were enrolled and they were randomly divided into two groups:the stud-y group (n=25 cases),which were given intra-articular injection of tranexamic acid (1 000 mg) and drain clamping for 2 hour posteratively, and the control group ( n=25 cases) ,which were given physiologic saline. The blood loss,postoperative volume of drainage,hemoglobin lev-el,hematocrit,blood transfusion cases,D-dimer level and deep venous tromboemblic ( DVT) events were recorded. Results Postoperative volume of drainage,blood transfusion cases and D-dimer level were lower in the study group (P<0. 05). Hemoglobin level and hematocrit were higher in the study group (P<0. 05). No DVT ocurred in the two groups. Conclusion Intra-articular injection of tranexamic acid with 2 hours of drain-clamping is effective for reducing postoperative blood loss in total knee replacement, and there is noincrease of deep venous tromboemblic.

  7. Economic Loan Loss Provision and Expected Loss

    Directory of Open Access Journals (Sweden)

    Stefan Hlawatsch

    2010-10-01

    Full Text Available The intention of a loan loss provision is the anticipation of the loan's expected losses by adjusting the book value of the loan. Furthermore, this loan loss provision has to be compared to the expected loss according to Basel II and, in the case of a difference, liable equity has to be adjusted. This however assumes that the loan loss provision and the expected loss are based on a similar economic rationale, which is only valid conditionally in current loan loss provisioning methods according to IFRS. Therefore, differences between loan loss provisions and expected losses should only result from different approaches regarding the parameter estimation within each model and not due to different assumptions regarding the outcome of the model. The provisioning and accounting model developed in this paper overcomes the before-mentioned shortcomings and is consistent with an economic rationale of expected losses. Additionally, this model is based on a close-to-market valuation of the loan that is in favor of the basic idea of IFRS. Suggestions for changes in current accounting and capital requirement rules are provided.

  8. 局部应用氨甲环酸减少初次单侧全膝关节置换术后失血量的临床研究%Clinical research of local application of tranexamic acid to reduce the blood loss after primary unilateral total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    李华贵; 常炳营; 王伟; 张丽欣; 郑晓梅

    2015-01-01

    目的:探讨局部应用氨甲环酸对初次单侧全膝关节置换术出血量的影响。方法:收治骨性关节炎行单侧全膝关节置换术患者68例,分为两组各34例:A组:局部灌注氨甲环酸,B组:局部灌注生理盐水。结果:A组与B组相比较,术后24 h、48 h引流量以及术后48 h血红蛋白量、血红蛋白下降百分比差异均具有统计学意义(P<0.05)。结论:在全膝关节置换术中局部应用氨甲环酸能明显减少患者失血量,且不增加静脉血栓形成的风险。%Objective:To investigate the effects of topical application of tranexamic acid for the blood loss after primary unilateral total knee arthroplasty.Methods:68 patients with osseous arthritis who had unilateral total knee arthroplasty were selected,they were divided into two groups with 34 cases in each:the A group:infusion of tranexamic acid,the B group:local perfusion of saline. Results:The A group compared with the B group,the difference of the postoperative 24h,48h lead traffic and the postoperative 48h hemoglobin,hemoglobin decreased rate had statistically significant(P<0.05).Conclusion:The topical application of tranexamic acid in total knee arthroplasty can decrease blood loss significantly and does not increase the risk of venous thrombosis.

  9. Blood Culture (For Parents)

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    ... KidsHealth in the Classroom What Other Parents Are Reading Upsetting News Reports? What to Say Vaccines: Which ... BMP) Blood Test: Complete Blood Count Basic Blood Chemistry Tests Getting a Blood Test (Video) Blood Test: ...

  10. Blood Clotting and Pregnancy

    Medline Plus

    Full Text Available ... For Patients Blood Disorders Blood Clots Blood Clotting & Pregnancy If you are pregnant, or you have just ... The risk of developing a blood clot during pregnancy is increased by the following: Previous blood clots ...

  11. Blood Count Tests

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    Your blood contains red blood cells (RBC), white blood cells (WBC), and platelets. Blood count tests measure the number and types of cells in your blood. This helps doctors check on your overall health. ...

  12. Blood pressure measurement

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    Diastolic blood pressure; Systolic blood pressure; Blood pressure reading; Measuring blood pressure ... or your health care provider will wrap the blood pressure cuff snugly around your upper arm. The ...

  13. Blood Transfusions (For Teens)

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    ... How Can I Help a Friend Who Cuts? Blood Transfusions KidsHealth > For Teens > Blood Transfusions Print A ... United States get blood transfusions. A Bit About Blood As blood moves throughout the body, it carries ...

  14. High Blood Pressure (Hypertension)

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    ... your doctor prescribes it, medicine. What Is Blood Pressure? Blood pressure is the force of blood flow inside ... Will I Know if I Have High Blood Pressure? High blood pressure is a silent problem — you won't ...

  15. Blood Pressure Quiz

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    ... page please turn Javascript on. Feature: High Blood Pressure Blood Pressure Quiz Past Issues / Fall 2011 Table of Contents ... About High Blood Pressure / Treatment: Types of Blood Pressure Medications / Blood Pressure Quiz Fall 2011 Issue: Volume 6 Number ...

  16. Hypertension (High Blood Pressure)

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    ... right away. continue How Do Doctors Measure Blood Pressure? Blood pressure readings are fast and painless. Blood pressure ... same age, height, and gender have lower blood pressure. Blood pressure between 90% and 95% of the normal ...

  17. Transfusion of blood and blood products: indications and complications.

    Science.gov (United States)

    Sharma, Sanjeev; Sharma, Poonam; Tyler, Lisa N

    2011-03-15

    Red blood cell transfusions are used to treat hemorrhage and to improve oxygen delivery to tissues. Transfusion of red blood cells should be based on the patient's clinical condition. Indications for transfusion include symptomatic anemia (causing shortness of breath, dizziness, congestive heart failure, and decreased exercise tolerance), acute sickle cell crisis, and acute blood loss of more than 30 percent of blood volume. Fresh frozen plasma infusion can be used for reversal of anticoagulant effects. Platelet transfusion is indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects. Cryoprecipitate is used in cases of hypofibrinogenemia, which most often occurs in the setting of massive hemorrhage or consumptive coagulopathy. Transfusion-related infections are less common than noninfectious complications. All noninfectious complications of transfusion are classified as noninfectious serious hazards of transfusion. Acute complications occur within minutes to 24 hours of the transfusion, whereas delayed complications may develop days, months, or even years later.

  18. 静脉应用不同剂量氨甲环酸对全膝关节置换围手术期失血的影响%The Intravenous Application of Different Doses of Tranexamic Acid on Total Knee Replacement ;Effect of Perioperative Blood Loss

    Institute of Scientific and Technical Information of China (English)

    潘云春; 刘琳娜; 张其亮

    2016-01-01

    Objective:To evaluate the intravenous injection of different dose of tranexamic acid on primary unilateral total knee arthroplasty peri operative blood loss quantity and safety influence.Method:From September 2012 to January 2014,250 cases of primary unilateral total knee arthroplasty in our hospital were selected as the research objects,they were randomly divided into the control group,tranexamic acid 10 mg/kg group,15 mg/kg group,20 mg/kg group and 30 mg/kg group,each group had 50 cases.Application of tranexamic acid of the four groups respectively at 30 min before tourniquet release the tranexamic acid in accordance with 10,15,20,30 mg/kg diluted in normal saline 100 mL by intravenous drip.Five groups began drainage in postoperative closed tube 2 h and drew tube postoperative 48 h.After 1,3,7 days hemoglobin content and hematocrit,most postoperative hemoglobin loss,total drainage volume and total blood loss,hidden blood loss, blood transfusion rate,postoperative venous thrombosis of the lower limbs occurred rate and other complications of five groups were recorded and compared.Result:The hemoglobin content and hematocrit of 1,3 and 7 d after operation among five groups were compared,there was no significant difference between the 20 mg/kg group and 30 mg/kg group(P>0.05),and there were significant differences between the other groups(P0.05).Venous thromboembolism(VTE), infection,renal failure and other complications were not found in the five groups.Conclusion:Intravenous application of 10,15,20 and 30 mg/kg dose of tranexamic acid can effectively reduce the blood loss and blood transfusion rates of the patients undergoing total knee arthroplasty,and will not increase the risk of perioperative venous thrombosis.To reduce bleeding,blood transfusion rate and possible risk analysis,20 mg/kg dose was the best dose.%目的:探讨静脉注射不同剂量氨甲环酸对初次单侧人工全膝关节置换围手术期失血量及安全

  19. Analysis on key problems of mountain torrent disaster loss assessment system in Liaohe River Basin

    Science.gov (United States)

    Chen, Jing

    2014-01-01

    Liaohe river basin mountain torrent disaster serious, this paper tells a system of flood loss assessment which would be helpful for the decrease of the geologic disastrous loss. Firstly, it mainly analyzes four uncertainties aspects of flood loss: precision of prediction and simulation, accounting standard of asset, asset vulnerability and flood prevention ability. Secondly, EasyDHM has been selected for forecast flood, the simulation forecast time is 6h before real flood peak coming; flood inundation model is selected for flood submerged level information extracted and flood submerged map. In the end, the model of flood Lose calculation is used to calculation the loss by the extracted information from stacking social economic data and water data. The feasibility of flood loss assessment system has been proved by flood simulation in 1998, 2003 and 2005. The unified assessment criteria make the assessment result difference, but this system of flood loss assessment has some value in system integration.

  20. Critical Inquiry for the Social Good: Methodological Work as a Means for Truth-Telling in Education

    Science.gov (United States)

    Kuntz, Aaron M.; Pickup, Austin

    2016-01-01

    This article questions the ubiquity of the term "critical" in methodological scholarship, calling for a renewed association of the term with projects concerned with social justice, truth-telling, and overt articulations of the social good. Drawing on Michel Foucault's work with parrhesia (or truth-telling) and Aristotle's articulation of…

  1. 20 CFR 404.1588 - Your responsibility to tell us of events that may change your disability status.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Your responsibility to tell us of events that may change your disability status. 404.1588 Section 404.1588 Employees' Benefits SOCIAL SECURITY... Continuing Or Stopping Disability § 404.1588 Your responsibility to tell us of events that may change...

  2. Vegetarian diet and blood pressure.

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    Beilin, L J; Armstrong, B K; Margetts, B M; Rouse, I L; Vandongen, R

    1987-01-01

    There is now convincing evidence from epidemiological studies and randomized controlled trials that adoption of an ovo-lacto vegetarian diet leads to blood pressure reduction in both normotensive and hypertensive subjects. This effect appears to be independent of both dietary sodium and weight loss but additive to effects of weight reduction. Long-term adherence to a vegetarian diet is associated with less of a rise of blood pressure with age and a decreased prevalence of hypertension. The nutrients responsible for these effects have not been clearly identified and the mechanisms involved are unknown. Resolution of these questions is needed to enable more widespread adoption of dietary changes which may reduce the prevalence of hypertension, reduce antihypertensive drug dependence and by effects on blood pressure and blood lipids ameliorate the natural history of hypertensive cardiovascular disease.

  3. Menopause and Bone Loss

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    Fact Sheet & Menopause Bone Loss How are bone loss and menopause related? Throughout life your body keeps a balance between the loss ... The sooner you take steps to prevent bone loss, the lower your risk of osteoporosis later in life. If you are skipping menstrual periods, have had ...

  4. The Loss of Multifractality in Migraines

    CERN Document Server

    Latka, M; Latka, D; West, B J; Latka, Miroslaw; Glaubic-Latka, Marta; Latka, Dariusz; West, Bruce J.

    2002-01-01

    We study the middle cerebral artery blood flow velocity (MCAfv) in humans using transcranial Doppler ultrasonography (TCD). The time series of the axial flow velocity averaged over a cardiac beat interval is found to exhibit clear multifractal properties for healthy subjects. We observe a loss of multifractality for subjects with migraine.

  5. What to Tell the Public? Information Design as Interpretation in Corridor Planning

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    Lebeaux, Pamela M.

    2012-01-01

    Providing information to the public is a widely recognized function of planning. Yet little attention has been paid to how expert information is characterized for citizens participating in a planning process. The text, maps and images used to tell the story in a planning process can help to bridge the divide between experts and citizens, or act to…

  6. Documenting the Then and the Now: Tucson Youth Tell Tucson Stories.

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    Eisele, Kimi

    2001-01-01

    A nonprofit organization in Tucson (Arizona) trains low-income adolescents to document neighborhood histories and tell their own. Working with professionals in the field, Mexican American and other minority youths learn to research, interview, write, photograph, and edit. After four books documenting Tucson history, a magazine was launched that…

  7. Predictors of Children's Prosocial Lie-Telling: Motivation, Socialization Variables, and Moral Understanding

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    Popliger, Mina; Talwar, Victoria; Crossman, Angela

    2011-01-01

    Children tell prosocial lies for self- and other-oriented reasons. However, it is unclear how motivational and socialization factors affect their lying. Furthermore, it is unclear whether children's moral understanding and evaluations of prosocial lie scenarios (including perceptions of vignette characters' feelings) predict their actual prosocial…

  8. Truth Telling in Foucault and Arendt: Parrhesia, the Pariah and Academics in Dark Times

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    Tamboukou, Maria

    2012-01-01

    In this paper, I consider the problem of truth telling through the notion of parrhesia as developed and explicated in Foucault's last lectures at the College de France (1982-1983 and 1983-1984) and the figure of the pariah that runs throughout Arendt's work. In tracing connections and tensions in the way the two thinkers explore questions and…

  9. Critical Inquiry as Virtuous Truth-Telling: Implications of Phronesis and Parrhesia

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    Pickup, Austin

    2016-01-01

    This article examines critical inquiry and truth-telling from the perspective of two complementary theoretical frameworks. First, Aristotelian phronesis, or practical wisdom, offers a framework for truth that is oriented toward ethical deliberation while recognizing the contingency of practical application. Second, Foucauldian parrhesia calls for…

  10. Investigating the early pottery Neolithic of northern Syria : New evidence from Tell Sabi Abyad

    NARCIS (Netherlands)

    Akkermans, PMMG; Cappers, R; Cavallo, C; Nieuwenhuyse, O; Nilhamn, B; Otte, IN

    2006-01-01

    The 2001-2003 excavations at Tell Sabi Abyad in northern Syria have provided important new information on the nature and development of the Pottery Neolithic settlement at the site in the seventh and sixth millennia B.C. The fieldwork has produced it long sequence of small and continually shifting o

  11. Telling Stories and Making Social Relations: Transnational Women's Ways of Belonging in Intercultural Contexts

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    Lee, Hakyoon

    2015-01-01

    This study investigates how transnational women construct their social relations by telling stories in a lingua franca environment (Firth 1996). My main interest lies in naturally occurring and interactionally achieved stories (Bamberg 2004; Georgakopoulou 2007) told during break time of an adult English as a Second Language (ESL) class in…

  12. The 2011 NCTE Presidential Address: Telling Our Stories ("Ka Ha'i Mo'olelo 'Ana")

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    Siu-Runyan, Yvonne

    2012-01-01

    This article presents the author's presidential address, delivered at the NCTE Annual Convention in Chicago, Illinois, on November 20, 2011. The author focuses on the powerful stories that define educators. The author's point is that telling one's story is one of the most important things an educator can do for those he/she teaches as well as for…

  13. A Story-Telling Approach for a Software Engineering Course Design

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2009-01-01

    patterns to increase maintainability when student exercises are never maintained? In this paper, we outline the contextual problems that software engineering teaching has to deal with and present a story telling approach for course design as a remedy. We outline the stories that over the last five years...

  14. How (and Why) to Tell Others about Your Epilepsy, Part 1

    Science.gov (United States)

    Mittan, Robert J.

    2009-01-01

    Probably one of the most challenging dilemmas facing people with epilepsy and parents of children with epilepsy are the questions of "if," "who," "when," and "how" to tell others about the epilepsy. There is fear of stigma and rejection. Yet there remains the need to reveal seizures before they reveal themselves without one's control. Telling…

  15. Schooling and Globalization: What Do We Tell Our Kids & Clients? What Are We Being Told?

    Science.gov (United States)

    Grant, Carl A.; Grant, Alicia

    2007-01-01

    With the effects of globalization everywhere, what should we say to our children and grandchildren about globalization and education? What are the print media--the books and magazines--telling us about globalization and education? This article examines what a person may take from the print media to talk with their children about effects of…

  16. Young Children's Metacognition in the Context of Telling a Written Story

    Science.gov (United States)

    Hsieh, Wu-Ying; Ku, Yu-Min; Chen, Yi-Hsin

    2013-01-01

    This study examines young children's metacognition in the context of telling a written story. The participants were 36 children: 12 preschoolers, 12 kindergarteners, and 12 first graders in a kindergarten and a nearby elementary school in a northwestern city in Taiwan. Each child was asked to "read" a 13-page wordless picture book…

  17. TELL SABI ABYAD, SYRIA : RADIOCARBON CHRONOLOGY, CULTURAL CHANGE, AND THE 8.2 KA EVENT

    NARCIS (Netherlands)

    van der Plicht, J.; Akkermans, P. M. M. G.; Nieuwenhuyse, O.; Kaneda, A.; Russell, A.

    2011-01-01

    At Tell Sabi Abyad, Syria, we obtained a robust chronology for the 7th to early 6th millennium BC, the Late Neolithic. The chronology was obtained using a large set of radiocarbon dates, analyzed by Bayesian statistics. Cultural changes observed at similar to 6200 BC are coeval with the 8.2 ka clima

  18. ‘Discovering a different me’ : Discursive positioning in life story telling over time

    NARCIS (Netherlands)

    Buitelaar, Marjo

    2014-01-01

    This article discusses agency in post-migration life story telling. Discussing excerpts from the life story of a well-known Moroccan Dutch town councillor as produced in 1999 and a follow up interview in 2008, it is demonstrated how the narrator strategically addresses and responds to various audien

  19. Telling Their Own Story: How Student Newspapers Reported Campus Unrest, 1962-1970

    Science.gov (United States)

    Armstrong, Kaylene Dial

    2013-01-01

    The work of student journalists often appears as a source in the footnotes when researchers tell the story of perhaps the most significant period in the history of higher education in the United States--the student protest era throughout the 1960s and early 1970s. Yet researchers and historians have ignored the student press itself during this…

  20. Effect of tranexamic acid on perioperative hidden blood loss in aged patients receiving intramedullary fixation for treatment of intertrochanteric fractures%氨甲环酸对老年股骨转子间骨折髓内固定术围手术期隐性失血的影响

    Institute of Scientific and Technical Information of China (English)

    朱云森; 江敞; 李俊

    2015-01-01

    Objective:To explore the effect of tranexamic acid on perioperative hidden blood loss in aged patients receiving intramedul-lary fixation for treatment of intertrochanteric fractures.Methods:Eighty-three aged patients with intertrochanteric fractures enrolled in the study were randomly divided into tranexamic acid group(43 cases)and conventional group(40 cases).All patients were treated with proxi-mal femoral nail antirotation(PFNA)internal fixation by the same group of surgeons.Intravenous drip infusions of tranexamic acid(10 mg/kg) were performed on patients in tranexamic acid group on the day of admission and before the start of the surgery respectively.Then the blood loss were measured and compared between the 2 groups and the postoperative deep vein thrombosis were also recorded.Results:There was no statistical difference in operation time and dominant blood loss between the 2 groups(32.58 +/-5.12 vs 31.90 +/-8.73 min,t =0.437,P =0.110;89.67 +/-15.24 vs 97.60 +/-14.65 mL,t =2.410,P =0.794),while hidden blood loss was less in the tranexamic acid group compared to the conventional group before and after the operation(84.91 +/-13.66 vs 154.08 +/-26.99 mL,t =14.883,P =0.000;158.23 +/-30.16 vs 286.15 +/-59.61 mL,t =12.460,P =0.013).Deep venous thrombosis was not found in both of the 2 groups.Conclusion:Application of tranexamic acid can effectively reduce perioperative hidden blood loss in aged patients receiving intr-amedullary fixation for treatment of intertrochanteric fractures,meanwhile it has high safety.%目的:探讨氨甲环酸对老年股骨转子间骨折髓内固定术围手术期隐性失血的影响。方法:将83例符合要求的老年股骨转子间骨折患者随机分为2组,氨甲环酸组43例、常规组40例。所有患者的手术均由同一组医生完成,均采用股骨近端防旋髓内钉内固定治疗,氨甲环酸组患者分别于入院当天和手术开始前静脉滴注氨甲环酸(10 mg·kg -1)1次。测定2组患

  1. Helping medical students to acquire a deeper understanding of truth-telling

    Directory of Open Access Journals (Sweden)

    Samia A. Hurst

    2015-11-01

    Full Text Available Problem: Truth-telling is an important component of respect for patients’ self-determination, but in the context of breaking bad news, it is also a distressing and difficult task. Intervention: We investigated the long-term influence of a simulated patient-based teaching intervention, integrating learning objectives in communication skills and ethics into students’ attitudes and concerns regarding truth-telling. We followed two cohorts of medical students from the preclinical third year to their clinical rotations (fifth year. Open-ended responses were analysed to explore medical students’ reported difficulties in breaking bad news. Context: This intervention was implemented during the last preclinical year of a problem-based medical curriculum, in collaboration between the doctor–patient communication and ethics programs. Outcome: Over time, concerns such as empathy and truthfulness shifted from a personal to a relational focus. Whereas ‘truthfulness’ was a concern for the content of the message, ‘truth-telling’ included concerns on how information was communicated and how realistically it was received. Truth-telling required empathy, adaptation to the patient, and appropriate management of emotions, both for the patient's welfare and for a realistic understanding of the situation. Lessons learned: Our study confirms that an intervention confronting students with a realistic situation succeeds in making them more aware of the real issues of truth-telling. Medical students deepened their reflection over time, acquiring a deeper understanding of the relational dimension of values such as truth-telling, and honing their view of empathy.

  2. Corona helps curb losses

    Energy Technology Data Exchange (ETDEWEB)

    Laasonen, M.; Lahtinen, M.; Lustre, L.

    1996-11-01

    The greatest power losses in electricity transmission arise through a phenomenon called load losses. Corona losses caused by the surface discharge of electricity also constitute a considerable cost item. IVS, the nationwide network company, is investigating corona- induced losses, and has also commissioned similar research from IVO International, the Technical Research Centre of Finland (VTT) and from Tampere University of Technology. The research work strives to gain more in-depth knowledge on the phenomenon of frosting and its impact on corona losses. The correct prediction of frost helps reduce corona losses, while also cutting costs considerably. (orig.)

  3. Globalisation and blood safety.

    Science.gov (United States)

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  4. Globalisation and blood safety.

    Science.gov (United States)

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  5. 血清和尿液中钙离子浓度作为骨丢失评价指标的初步探讨%Preliminary Exploration on Ca2+ Concentration in Blood Serum and Urine as Evaluation Indicator of Bone Loss

    Institute of Scientific and Technical Information of China (English)

    杨宪园; 丁冲; 王哲; 王林杰; 商澎

    2012-01-01

    Objective To determine the Ca2+ concentration in blood serum and urine and explore the feasibility as the early phase indirect indicator for evaluation of bone loss. Methods Tail suspension( TS) was used as the animal model of bone loss under simulated weightlessness. Eight three-month SD female rats were in each group (TS and Con group). Urine samples were collected every two days. After 3 weeks, the rats were anesthetized , their body weight were weighed, the bone mineral densities ( BMD) of femur and tibia were determined with the dual-energy X-ray absorptiometry device and the artery blood samples were taken. The blood samples were centrifuged and the serum was separated. The Ca + concentration of urine and serum were measured with the ion-selective electrode technique. The femur and tibia in the right side were taken and cleaned carefully and put into the resistance furnace. The bone dry mass and bone ashes mass were weighed. Results The body weight had an obvious downtrend after one week of TS(P <0. 01) and the urine Ca2+ concentration had a clear rise(P <0. 01 ,P <0. 001). The BMD of femur declined obviously on the second and third week (P< 0.001). Bone dry mass also changed obviously (P < 0. 05). Conclusion Ca2+ concentration in urine can be used as the indirect indicator for evaluation of bone loss.%目的 探讨体液中钙离子浓度作为早期评价骨丢失间接指标的可行性.方法 采用尾悬吊模拟失重性骨丢失为动物模型,悬吊组和对照组各8只3月龄SD雌性大鼠,悬吊时间为3周.大鼠每2d收集1次尿液;每周麻醉1次称重,并使用骨密度仪测量股骨和胫骨处的骨密度;实验结束大鼠麻醉后动脉取血,分离血清,采用离子敏感电极技术检测尿液和血清中钙离子浓度.分离大鼠右侧股骨和胫骨,烘烤后称量骨干质量和骨灰质量.结果 大鼠尾悬吊1周后体重明显下降(P<0.01);尿液中钙离子浓度显著升高(P<0.01,P<0.001);

  6. Comparison of Effects on Intravenous and Intra-Articular Cavity Injection of Tranexamic Acid on Blood Loss Volume in Total Knee Arthroplasty%静脉与关节腔内使用氨甲环酸对全膝关节置换术失血量的影响比较

    Institute of Scientific and Technical Information of China (English)

    蒋华; 颜宇; 马红兵; 曾勇; 徐兵; 王俊瑞

    2015-01-01

    目的:对比静脉滴注与关节腔内局部注射氨甲环酸对控制全膝关节置换术(TKA)失血量的有效性及手术安全性。方法将医院2012年1月至2014年10月收治的行全膝关节置换术患者73例随机分为静脉滴注组(对照组)40例和腔内使用组(治疗组)33例,其中静脉滴注组患者在麻醉诱导期使用氨甲环酸10 mg/kg,最大剂量1 g;腔内使用组患者术中关节囊缝合完成且止血带未放松前将氨甲环酸1g注入关节腔。结果腔内使用组术后总失血量较静脉滴注组明显减少( P<0.05),术后检测凝血功能(PT,APTT,INR)、深静脉血栓(DVT)发生率与静脉滴注组相比,差异有统计学意义( P ?0.05);结论关节腔内注射氨甲环酸是一种能有效控制全膝关节置换术后失血量且较安全的方案,不增加术后深静脉血栓发生概率。%Objective To compare the effects and operative safety of intravenous drip and intra-articular cavity local injection of tranexamic acid on controlling blood loss volume in total knee arthroplasty. Methods Totally 73 patients with total knee arthroplasty treated in the hospital from January 2012 to October 2014 were randomly divided into the intravenous drip group(IVTA,contorl group, 40 cases) and the intra-articular use group(IATA,treatment group,33 cases). The patients in the control group used intravenous tranexamic acid 10 mg/kg,with the maximum dose 1. 0 g during the anesthetic induction period,while the patients in the treatment group were intra-articularlly injected by tranexamic acid 1 g at the finishing of articular capsule suture and before relaxing the tourni-quet. Results The postoperative total blood loss volume in the control group was significantly decreased compared with that in the treatment group( P < 0. 05);there were no statistically significant differences in the postoperative coagulation function(PT,APTT,INR) and the incidence rate of deep

  7. Blood Clotting and Pregnancy

    Medline Plus

    Full Text Available ... 6, 2016, San Diego, CA Abstracts Registration Housing Travel Information Government Concierge View all meetings Publications Blood ... Blood Clots Blood Clotting and Pregnancy Clots and Travel DVT Myths vs. Facts Blood Detectives Find a ...

  8. Where to Donate Blood

    Science.gov (United States)

    ... zip code using the Blood Bank Locator below: Blood Bank Locator City: State/Province: ZIP Code: Country: Show ... safety and care. The Association sets standards for blood banks and transfusion services, and accredits member blood banks ...

  9. High blood pressure

    Science.gov (United States)

    ... you are at risk for: Bleeding from the aorta, the large blood vessel that supplies blood to ... tests Blood pressure check Blood pressure References American Diabetes Association. Standards of medical care in diabetes-2015 ...

  10. Lead levels - blood

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    Blood lead levels ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... may be used to puncture the skin. The blood collects in a small glass tube called a ...

  11. Types of Blood Donations

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    ... Double Red Cell Plasma Platelets Red Cells What blood donation type is best for me? **If you do not ... blood type, a whole blood donation is recommended** Blood Donation Types: Volunteer Donations The standard or most common type ...

  12. Blood Type Game

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    ... Donor Community > Games > Blood Type Game Printable Version Blood Type Game This feature requires version 6 or later ... many points as possible by matching the appropriate blood type of a donor to the blood type of ...

  13. Blood Transfusion and Donation

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    ... in the United States receive life-saving blood transfusions. During a transfusion, you receive whole blood or parts of blood ... liver failure or a severe infection. Most blood transfusions go very smoothly. Some infectious agents, such as ...

  14. Blood Transfusion (For Parents)

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Blood Transfusions KidsHealth > For Parents > Blood Transfusions Print A ... and help put your child at ease. About Blood Transfusions Blood is like the body's transportation system. ...

  15. Understanding Blood Pressure Readings

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    ... What is the AHA recommendation for healthy blood pressure? This blood pressure chart reflects categories defined by the American ... unusually low blood pressure readings. How is high blood pressure diagnosed? Your healthcare providers will want to get ...

  16. Blood Clotting and Pregnancy

    Medline Plus

    Full Text Available ... Housing Travel Information Government Concierge View all meetings Publications Blood Current Issue First Edition Abstracts Blood Advances ... reflect the most recent scientific research View all publications For Patients Blood Basics Blood Disorders Anemia Bleeding ...

  17. Relationship between leukocyte count and its genera in peripheral blood with incipient hearing loss and prognosis in patients with sudden sensorineural hearing loss%突发性耳聋患者外周血白细胞计数及分属与初发听力损失和预后的相关性

    Institute of Scientific and Technical Information of China (English)

    李璠; 李峰; 鲁建光

    2015-01-01

    目的 探讨突发性耳聋(sudden sensorineural hearing loss,SSHL)患者外周血白细胞计数及分属与初发听力损失程度和预后的相关性.方法 SSHL患者70例,常规进行血液学检查,记录外周血白细胞总数、中性粒细胞百分比、淋巴细胞百分比等项指标.分别采集治疗前后的纯音测听结果,观察白细胞计数和分属与患者初发听力损失程度和疗效的关系,以30例健康体检者的相关参数作为对照.结果 SSHL组患者外周血白细胞计数、中性粒细胞百分比明显高于健康对照组,淋巴细胞百分比明显低于健康对照组(P<0.05);SSHL组患者白细胞计数和分属与初发听力损失程度无明显相关性(P>0.05),而外周血白细胞计数升高、中性粒细胞百分比升高及淋巴细胞百分比降低的患者治疗效果则明显较差(P<0.05).结论 SSHL患者发病前可能存在感染因素,外周血白细胞计数和中性粒细胞百分比升高、淋巴细胞百分比降低可能提示患者预后不良.

  18. Hair Loss (Alopecia)

    Science.gov (United States)

    ... Eating disorder: When a person has an eating disorder, hair loss is common. Anorexia (not eating enough) and bulimia (vomiting after eating) can cause hair loss. Medicine Some prescription medicines can cause ...

  19. Hair Loss (Alopecia Areata)

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    ... rash and rashes clinical tools newsletter | contact Share | Hair Loss (Alopecia Areata) Information for adults A A A This ... scalp with a round area of non-scarring hair loss typical of alopecia areata. Overview Alopecia areata is ...

  20. Weight Loss Surgery

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    Weight loss surgery helps people with extreme obesity to lose weight. It may be an option if you ... caused by obesity. There are different types of weight loss surgery. They often limit the amount of food ...

  1. Coping with Memory Loss

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    ... Consumers Home For Consumers Consumer Updates Coping With Memory Loss Share Tweet Linkedin Pin it More sharing ... a health professional. back to top What Causes Memory Loss? Anything that affects cognition—the process of ...

  2. Genes and Hearing Loss

    Science.gov (United States)

    ... Meeting Calendar Find an ENT Doctor Near You Genes and Hearing Loss Genes and Hearing Loss Patient ... mutation may only have dystopia canthorum. How Do Genes Work? Genes are a road map for the ...

  3. Recurrent pregnancy loss

    DEFF Research Database (Denmark)

    Egerup, P; Kolte, A M; Larsen, E C;

    2016-01-01

    STUDY QUESTION: Is there a different prognostic impact for consecutive and non-consecutive early pregnancy losses in women with secondary recurrent pregnancy loss (RPL)? SUMMARY ANSWER: Only consecutive early pregnancy losses after the last birth have a statistically significant negative prognostic...... impact in women with secondary RPL. WHAT IS KNOWN ALREADY: The risk of a new pregnancy loss increases with the number of previous pregnancy losses in patients with RPL. Second trimester losses seem to exhibit a stronger negative impact than early losses. It is unknown whether the sequence of pregnancy...... losses plays a role for the prognosis in patients with a prior birth. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study of pregnancy outcome in patients with unexplained secondary RPL included in three previously published, Danish double-blinded placebo-controlled trials of intravenous...

  4. Genetics of Hearing Loss

    Science.gov (United States)

    ... in Latin America Information For... Media Policy Makers Genetics of Hearing Loss Language: English Español (Spanish) Recommend ... of hearing loss in babies is due to genetic causes. There are also a number of things ...

  5. Pregnancy Loss and Miscarriage

    Science.gov (United States)

    ... Share this: Page Content What is pregnancy loss/miscarriage? A miscarriage, also called pregnancy loss or spontaneous abortion, is ... D.A.M. Medical Encyclopedia. (2010, November 21). Miscarriage . Retrieved May 21, 2012, from http://www.ncbi. ...

  6. Prospective comparative research on blood loss after total hip arthroplasty between single dose intraarticular injection of tranexamic acid and during operation and postoperative injection of tranexamic acid%氨甲环酸止血对全髋关节置换术围术期失血量影响

    Institute of Scientific and Technical Information of China (English)

    华政哲; 张敬东; 韩文峰; 何勇; 张攀; 孙保飞

    2015-01-01

    目的 评价术中髋臼及股骨髓腔创面应用氨甲环酸止血同时在关闭切口后经引流管髋关节腔内单次灌注应用氨甲环酸止血和关闭切口后经引流管髋关节腔内单次灌注应用氨甲环酸止血对全髋关节置换围手术期失血量的影响. 方法前瞻性研究分析自2014年1月至2015年1月收治的64例因股骨头坏死行全髋关节置换术患者,按治疗方法不同分为A组和B组. A组患者32例:关闭切口后,经引流管髋关节腔内单次灌注氨甲环酸2. 5 g(25 ml)止血. B组患者32例:术中髋臼及股骨髓腔创面分别应用0. 5 g(5 ml)氨甲环酸浸润,并用纱布填塞止血,同时在关闭切口后经引流管髋关节腔内单次灌注1. 5 g(15 ml)氨甲环酸止血. 两组患者均由同一术者、同一术式完成全髋关节置换. 比较两组患者手术时间、术中失血量、术后引流量、术后血红蛋白变化和总失血量. 结果 术后24 h,A组患者血红蛋白为(10. 4 ±0. 8)g/L,B组(11. 6 ±0. 9)g/L,两组间比较差异有统计学意义(P0. 05). 两组患者术后均未发生假体周围感染、下肢深静脉血栓或其他并发症. 结论 全髋关节置换术中,髋臼及股骨髓腔创面应用氨甲环酸止血同时,在关闭切口后经引流管髋关节腔内局部灌注氨甲环酸止血,较关闭切口后经引流管髋关节腔内单次灌注氨甲环酸止血效果更好,并且不增加手术时间、假体周围感染及静脉血栓形成的风险.%Objective To explore the efficiency of single dose intra-articular injection of tranexamic acid( TXA) and during operation and postoperative injection of tranexamic acid on the blood loss after total hip arthroplasty(THA). Methods A total of 64 patients with necrosis of femoral head,who were performed THA,were prospective analyzed. Due to the TXA control method,patients were ran-dom divided into two groups including single dose intra-articular injection of tranexamic acid group( A group

  7. 氨甲环酸对膝关节置换术患者静脉与关节内失血的影响研究%Effect of tranexamic acid on blood loss in vein and joint of patients with total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    唐炼

    2014-01-01

    目的:研究氨甲环酸对膝关节置换术患者失血情况的影响。方法选取2012年1月~2013年12月到泸州医学院附属医院就诊并确诊为原发性骨性关节炎的患者共90例,均择期进行首次单侧全膝关节置换术,并随机将患者分为3组,实验一组采用静脉输注氨甲环酸,实验二组在膝关节局部注射氨甲环酸,实验三组不给予氨甲环酸,检测3组患者术后48 h内的血红蛋白含量和总失血量,记录7 d内的体表瘀斑情况,并进行比较。结果实验一组与实验二组术后20 h和48 h血红蛋白含量均明显多于实验三组(P<0.05);3组术后20 h和48 h血红蛋白含量均少于术前(P<0.05),且术后48 h血红蛋白含量少于术后20 h。实验一组和实验二组术后总失血量、输血例数和皮下瘀斑发生率均明显低于实验三组(P<0.05),但实验一组和实验二组之间的各项数据差异无统计学意义。所有患者均没有发生深静脉血栓。结论氨甲环酸能够减少膝关节置换术后的失血量,减轻了患者的病痛和经济负担。%Objective To study the effect of tranexamic acid on the blood loss in vein and joint of patients with total knee arthroplasty. Methods 90 patients diagnosed with primary osteoarthritis from January 2012 to December 2013 were selected as subject.They were scheduled for the first-time unilateral total knee arthroplasty.All patients were divided into three groups randomly.Experimental group one was tranexamic acid intravenously,Experiment group two was given tranexamic acid with knee local injection,and Experimental group three was given nothing.Hemoglobin and total blood loss were detected and compared in 48 hours after operation in three groups;subcutaneous ecchymosis situation within 7 days were recorded and compared.Results Hemoglobin levels of Experiment group one and Experiment group two in 20 hours and 48 hours after operation were more than

  8. Types of Blood Transfusions

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    ... Home » Health Information for the Public » Health Topics » Blood Transfusion » Types of Blood Transfusions Explore Blood Transfusion What Is... ... Share this page from the NHLBI on Twitter. Types of Blood Transfusions Blood is transfused either as whole blood ( ...

  9. Cord blood testing

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    ... to evaluate the oxygen, carbon dioxide, and pH levels) Blood sugar level Blood type and Rh Complete blood count ( ... means you have a blood infection (septicemia). High levels of blood sugar (glucose) in the cord blood may be found ...

  10. Hearing loss and music

    Science.gov (United States)

    Noise induced hearing loss - music; Sensory hearing loss - music ... damaged by loud sounds. The human ear is like any other body part -- too much use can damaged it. Over time, repeated exposure to loud noise and music can cause hearing loss.

  11. The effect of misoprostol on intraoperative blood loss after myomectomy

    Directory of Open Access Journals (Sweden)

    Mansoureh Vahdat

    2015-06-01

    Conclusions: Preoperative use of sublingual misoprostol is effective in reducing IBL for women undergoing myomectomies in short time (after 6 h. Further studies should be performed to investigate the effectiveness of preoperative misoprostol with various routes and doses in other post-operative time on reducing IBL in abdominal myomectomy. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 776-779

  12. Beam Loss in Linacs

    CERN Document Server

    Plum, M A

    2016-01-01

    Beam loss is a critical issue in high-intensity accelerators, and much effort is expended during both the design and operation phases to minimize the loss and to keep it to manageable levels. As new accelerators become ever more powerful, beam loss becomes even more critical. Linacs for H- ion beams, such as the one at the Oak Ridge Spallation Neutron Source, have many more loss mechanisms compared to H+ (proton) linacs, such as the one being designed for the European Spallation Neutron Source. Interesting H- beam loss mechanisms include residual gas stripping, H+ capture and acceleration, field stripping, black-body radiation and the recently discovered intra-beam stripping mechanism. Beam halo formation, and ion source or RF turn on/off transients, are examples of beam loss mechanisms that are common for both H+ and H- accelerators. Machine protection systems play an important role in limiting the beam loss.

  13. Intracorneal blood removal six weeks after canaloplasty

    Directory of Open Access Journals (Sweden)

    Alberto Rossetti

    2013-01-01

    Full Text Available In a 71-year-old patient with bilateral open-angle glaucoma, intracorneal blood was found after a canaloplasty procedure in the right eye. Six weeks after surgery on ultrasound biomicroscopy examination, liquified blood and blood clots could be observed nasally in the deep corneal stroma close to the Descemet′s membrane. The intracorneal blood was washed out with balanced saline solution following deep corneal incision and lamellar dissection. Descemet′s membrane was reattached with air injection into the anterior chamber. Two months later, visual acuity improved to 20/50, intraocular pressure was 16 mm Hg without medication and confocal microscopy showed deep stromal folds and limited endothelial cell loss. Viscoelastic entering the cornea at Schwalbe′s line and reflux of blood from the collector channels to Schlemm′s canal can account for corneal hematoma. Even six weeks after canaloplasty, successful blood removal could be fulfilled without rupturing the Descemet′s membrane.

  14. Blood transfusion practices in cancer surgery

    Directory of Open Access Journals (Sweden)

    Juan P Cata

    2014-01-01

    Full Text Available Cancer patients are commonly transfused with blood products immediately before, during or after major surgery. Blood loss and haemodilution are the most common causes of red blood cells (RBCs administration and coagulopathies are the indications for the infusion of fresh-frozen plasma (FFP, cryoprecipitates and platelets. Transfusion-related immune modulation is a complication associated with the administration of blood products. A decreased immune surveillance as a consequence of blood transfusions has been linked to cancer recurrence and progression. Moreover, soluble factors present in packed RBCs, platelets and FFP can directly stimulate tumour growth and spread. Two meta-analyses suggest that the administration of blood products is associated with shorter recurrence-free survival and overall survival after colorectal cancer surgery. More studies are needed to show such association in different cancer patient populations.

  15. Telling better stories: strengthening the story in story and simulation

    Science.gov (United States)

    Kemp-Benedict, Eric

    2012-12-01

    analysis', which maximizes a quantitative measure of the spread of a set of qualitative scenarios defined by states of driving forces (Carlsen 2009). It could also include a survey of different worldviews, and the qualitative models that they imply, such as that carried out by Sunderlin (Sunderlin 2003). Futures studies has moved forward from the time the SRES was published, and new techniques are now available that can help us to tell better stories of the future. References Alcamo J 2001 Scenarios as Tools for International Environmental Assessments (Cophenhagen: European Environment Agency) Alcamo J 2008 The SAS approach: combining qualitative and quantitative knowledge in environmental scenarios Environmental Futures—The Practice of Environmental Scenario Analysis vol 2, ed J Alcamo (Amsterdam: Elsevier) pp 123-50 Carlsen H 2009 Climate change and the construction of scenario sets that span the range of societal uncertainties Paper for International Studies Association Annual Convention 2009 (New York City, February) Jackson T 2009 Prosperity Without Growth: Economics for a Finite Planet (London: Earthscan) Kriegler E, O'Neill B C, Hallegatte S, Kram T, Lempert R J, Moss R H and Wilbanks T 2012 The need for and use of socio-economic scenarios for climate change analysis: a new approach based on shared socio-economic pathways Glob. Environ. Change 22 807-22 Nakicenovic N and Swart R (eds) 2000 Special Report on Emissions Scenarios (Cambridge: Cambridge University Press) Raskin P, Monks F, Ribeiro T, van Vuuren D and Zurek M 2005 Global scenarios in historical perspective Ecosystems and Human Well-Being: Scenarios: Findings of the Scenarios Working Group vol 2, ed S R Carpenter et al (Washington, DC: Island) pp 35-44 Schweizer V J and Kriegler E 2012 Improving environmental change research with systematic techniques for qualitative scenarios Environ. Res. Lett. 7 044011 Sunderlin W D 2003 Ideology, Social Theory, and the Environment (Lanham, MD: Rowman & Littlefield

  16. Reiter's syndrome and hearing loss: a possible association?

    OpenAIRE

    Monsanto, Rafael C; Neto, Arlindo C L; Lorenzetti, Fábio T M

    2014-01-01

    Key Clinical Message Patient complained of hearing loss and tinnitus after the onset of Reiter's syndrome. Audiometry confirmed the hearing loss on the left ear; blood work showed increased erythrocyte sedimentation rate and C3 fraction of the complement. Genotyping for HLA-B27 was positive. Treatment with prednisolone did not improve the hearing levels.

  17. Intra-articular and intravenous injection of tranexamic acid effectively reduces blood loss after total knee arthroplasty%氨甲环酸关节腔给药联合静脉给药可有效减少全膝关节置换后出血

    Institute of Scientific and Technical Information of China (English)

    徐建; 哈承志; 田少奇; 王远贺; 刘宁宁; 孙康

    2016-01-01

    背景:有研究表明氨甲环酸能够有效减少全膝关节置换术患者的术后出血量,但是氨甲环酸的给药方式有多种,包括关节腔注射,静脉注射和两者联合用药,但效果尚无定论。  目的:探讨关节腔注射,静脉注射和两者联合用药3种氨甲环酸给药方式是否能够有效的减少全膝关节置换后出血。  方法:试验选择2014年12月到2015年12月进行单侧全膝关节置换术的患者103例,根据氨甲环酸的给药方式不同随机分为4组:关节腔注射组术中膝关节切口缝合后给予关节腔注射液2000 mg氨甲环酸;静脉注射组在止血带使用前15 min静脉注射1000 mg氨甲环酸;联合治疗组采用上述2种方法联合干预;空白对照组不采用氨甲环酸干预。  结果与结论:①总出血量和输血率:关节腔注射组和联合治疗组的总出血量和输血率均少于静脉给药组(P 0.05),两组输血率均为0%;②不良反应:各组中均未出现深静脉血栓、肺部血栓、切口感染、血肿和坏疽等不良反应;③结果证实:氨甲环酸关节腔给药联合静脉给药可有效减少全膝关节置换后出血,效果略优于单独给药。%BACKGROUND: Studies have shown that tranexamic acid can effectively reduce postoperative blood loss in patients with total knee arthroplasty. There are many means to inject tranexamic acid (intra-articular injection, intravenous injection and their combination). Which is the best way has no conclusion. OBJECTIVE: To explore whether all three ways (intra-articular injection, intravenous injection and their combination) to inject tranexamic acid can all effectively reduce the bleeding after total knee arthroplasty. METHODS:103 patients undergoing unilateral total knee arthroplasty from December 2014 to December 2015 were enrolled in this study. The patients were allocated into four groups according to injection way. In the intra

  18. Beta-carotene blood test

    Science.gov (United States)

    Carotene test ... anything for up to 8 hours before the test. You may also be asked not to eat ... vitamin A (carotene) for 48 hours before the test. Your provider may also tell you to temporarily ...

  19. What information can frictional properties of polymer brushes tell us?

    Science.gov (United States)

    Zhang, Zhenyu; Moxey, Mark; Morse, Andrew; Armes, Steven; Lewis, Andrew; Geoghegan, Mark; Leggett, Graham

    2013-03-01

    We have used friction force microscopy (FFM) to quantitatively examine surface grown zwitterionic polymer brushes: poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), and to establish the correlation between its frictional behaviour to other intrinsic properties. In a good solvent, it was found that the coefficient of friction (μ) decreased with increasing film thickness. We conclude that the amount of bound solvent increases as the brush length increases, causing the osmotic pressure to increase and yielding a reduced tendency for the brush layer to deform under applied load. When measured in a series of alcohol/water mixtures, a significant increase in μ was observed for ethanol/water mixtures at a volume fraction of 90%. This is attributed to brush collapse due to co-nonsolvency, leading to loss of hydration of the brush chains and hence substantially reduced lubrication. We show that single asperity contact mechanics is strongly dependent on solvent quality. Friction-load relationship was found linear in methanol (good solvent), but sub-linear in water and ethanol (moderate solvent).

  20. 全膝关节置换后静脉与局部应用氨甲环酸对失血量的影响%Effects of intravenous versus topical application of tranexamic acid on blood loss following total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    柴星宇; 苏长征; 庞涛; 吕东; 朱彪; 侯振扬; 李振; 许正文; 赵廷宝

    2015-01-01

    背景:目前关于全膝关节置换过程中使用氨甲环酸减少出血的报道越来越多,但对于使用方式的选择仍存在争议。  目的:通过术中关节腔周围组织局部注射和静脉注射两种不同的给药途径,探讨氨甲环酸对初次单侧全膝关节置换后失血量的影响。  方法:根据随机对照原则设计,选取滕州市中心人民医院2013年10月至2014年12月收治拟行单侧全膝关节置换的患者90例,随机分为静脉组和局部组(n=45)。静脉组患者在全身麻醉诱导期接受静脉输注氨甲环酸(10 mg/kg 最大剂量1.2 g);局部组于假体安装结束后,缝合关节囊前,在关节周围软组织注射氨甲环酸(2 g溶于50 mL生理盐水)。比较两组患者置换后引流量、置换后次日血红蛋白及红细胞压积、输血例数,同时观察是否有肺栓塞及下肢深静脉栓塞的临床症状出现,必要时行下肢血管多普勒超声检查。  结果与结论:置换后引流量、置换后次日血红蛋白值及红细胞压积、输血人数及输血比率比较,两组差异无显著性意义(P>0.05)。两组患者置换后14 d 均未发现下肢深静脉血栓形成。提示与静脉全身应用相比,全膝关节置换过程中关节周围局部应用氨甲环酸同样能达到有效减少置换后失血和输血的效果,并可避免静脉应用氨甲环酸可能带来的相关并发症。%BACKGROUND:Increasing reports have focused on the application of tranexamic acid to reduce bleeding during total knee arthroplasty, but its usage method remains controversial. OBJECTIVE:To explore the impact of topical articular application of tranexamic acid and intravenous application of tranexamic acid on blood loss during primary unilateral total knee arthroplasty. METHODS:According to randomized control ed principle, 90 patients who received unilateral total knee arthroplasty in the Tengzhou Central People’s Hospital from

  1. The rise of repeal: policy entrepreneurship and Don't Ask, Don't Tell.

    Science.gov (United States)

    Neff, Christopher L; Edgell, Luke R

    2013-01-01

    We report on policy entrepreneurship by Servicemembers Legal Defense Network (SLDN) and how its legislative strategies used mini-windows of opportunity to shift Capitol Hill perspectives of Don't Ask, Don't Tell (DADT) from political plutonium to an emerging issue requiring a second look. Four phases in the legislative history of DADT are identified: radioactive, contested, emerging, and viable. In all, this article argues that SLDN's entrepreneurship focused on contesting congressional sensibilities to wait or defer on repeal, maintained that every discharge was damaging and transitioned toward a post-repeal mind set. Finally, we illustrate the importance of these transitions by comparing SLDN's 2004 estimated vote count for the introduction of the Military Readiness Enhancement Act with the final 2010 voting results on the Don't Ask, Don't Tell Repeal Act.

  2. Tragic knowledge: truth telling and the maintenance of hope in surgery.

    Science.gov (United States)

    Suri, Megha; McKneally, Martin; Devon, Karen

    2014-07-01

    Surgeons often are faced with the challenge of balancing truth telling and the maintenance of hope in the setting of a poor prognosis. This ethical dilemma is informed by conflicting appeals to principles of autonomy and nonmaleficence, where a patient's right to be told important medical information must be weighed against the potential harm that may result from the knowledge of an unfavourable diagnosis. Truth telling in surgery raises questions on the nature of truth itself, how much information ought to be shared, what information can be withheld, and how surgeons should share tragic knowledge with patients. This paper will address these questions and provide some insight on how surgeons may navigate the sharing of tragic knowledge.

  3. Telling stories and adding scores: Measuring resilience in young children affected by maternal HIV and AIDS.

    Science.gov (United States)

    Ebersöhn, Liesel; Eloff, Irma; Finestone, Michelle; Grobler, Adri; Moen, Melanie

    2015-01-01

    "Telling stories and adding scores: Measuring resilience in young children affected by maternal HIV and AIDS", demonstrates how a concurrent mixed method design assisted cross-cultural comparison and ecological descriptions of resilience in young South African children, as well as validated alternative ways to measure resilience in young children. In a longitudinal randomised control trial, which investigated psychological resilience in mothers and children affected by HIV/AIDS, we combined a qualitative projective story-telling technique (Düss Fable) with quantitative data (Child Behaviour Checklist). The children mostly displayed adaptive resilience-related behaviours, although maladaptive behaviours were present. Participating children use internal (resolve/agency, positive future expectations, emotional intelligence) and external protective resources (material resources, positive institutions) to mediate adaptation. Children's maladaptive behaviours were exacerbated by internal (limited problem-solving skills, negative emotions) and external risk factors (chronic and cumulative adversity).

  4. The Narrative Aspect of Scenario Building -How Story Telling may give people a memory of the future

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard

    2005-01-01

    The quality of scenarios depends on relevant assumptions and authentic scenario stories. The article explore how the narrative approach may enrich the scenario . in addition, criteria are suggested for evaluation of the qualioty of scenario story telling......The quality of scenarios depends on relevant assumptions and authentic scenario stories. The article explore how the narrative approach may enrich the scenario . in addition, criteria are suggested for evaluation of the qualioty of scenario story telling...

  5. Being asked to tell an unpleasant truth about another person activates anterior insula and medial prefrontal cortex

    DEFF Research Database (Denmark)

    Littlefield, Melissa M; Dietz, Martin; Fitzgerald, Des;

    2015-01-01

    “Truth” has been used as a baseline condition in several functional magnetic resonance imaging (fMRI) studies of deception. However, like deception, telling the truth is an inherently social construct, which requires consideration of another person’s mental state, a phenomenon known as Theory of ...... that the cortical regions engaged by truth telling show a distinct pattern when the task requires social reasoning....

  6. When Video Games Tell Stories: A Model of Video Game Narrative Architectures

    OpenAIRE

    Marcello Arnaldo Picucci

    2014-01-01

    In the present study a model is proposed offering a comprehensive categorization of video game narrative structures intended as the methods and techniques used by game designers and allowed by the medium to deliver the story content throughout the gameplay in collaboration with the players. A case is first made for the presence of narrative in video games and its growth of importance as a central component in game design. An in-depth analysis ensues focusing on how games tell stories, guided ...

  7. Every picture tells a story. Communicatie door gebruik van innovatieve datavisualisatie: Aanvraag RAAK-MKB

    OpenAIRE

    Bakker, Piet

    2011-01-01

    Het doel van het project Every Picture Tells a Story is om samen met het werkveld methoden, technieken en kennis te ontwikkelen voor het produceren van effectieve infographics. Dit is nodig omdat de vraag naar infographics in de markt snel toeneemt. Bedrijfsleven en overheden kiezen er steeds vaker voor om infographics te gebruiken om grote hoeveelheden of complexe informatie begrijpelijk te maken voor hun doelgroepen. Om aan de vraag van deze opdrachtgever te kunnen blijven voldoen hebben pr...

  8. Does special relativity theory tell us anything new about space and time?

    OpenAIRE

    Szabo, Laszlo E.

    2003-01-01

    It will be shown that, in comparison with the pre-relativistic Galileo-invariant conceptions, special relativity tells us nothing new about the geometry of spacetime. It simply calls something else "spacetime", and this something else has different properties. All statements of special relativity about those features of reality that correspond to the original meaning of the terms "space" and "time" are identical with the corresponding traditional pre-relativistic statements. It will be also a...

  9. Let the man choose what to do: Neural correlates of spontaneous lying and truth-telling.

    Science.gov (United States)

    Yin, Lijun; Reuter, Martin; Weber, Bernd

    2016-02-01

    Many previous functional magnetic resonance imaging (fMRI) studies on deception used a paradigm of "instructed lies", which is different than other, more spontaneous forms of lying behavior. The present study aimed to investigate the neural processes underlying spontaneous and instructed lying and truth-telling, and to investigate the different mechanisms involved. This study used a modified sic bo gambling game with real payoffs in order to induce lying. In the spontaneous sessions, the participants themselves decided whether or not to lie, whereas in the instructed sessions they were explicitly told to respond either honestly or dishonestly. In the spontaneous lying (vs. truth-telling) condition, the subgenual anterior cingulate cortex (sACC) showed significantly higher activity, whereas the right dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC) and inferior parietal lobule (IPL) were more strongly activated when participants spontaneously told the truth (vs. lied). Our results suggest that the extra cognitive control required for suppressing the self-interest motives in spontaneous truth-telling is associated with higher activity in the fronto-parietal network, while the process of negative emotion in spontaneous lying induced greater involvement of the sACC. Although similar to spontaneous deception, instructed deception engenders greater involvement of the right inferior frontal gyrus (IFG), left supplementary motor area (SMA), anterior cingulate cortex (ACC), IPL and superior frontal gyrus (SFG) compared to baseline, instructed decisions did not elicit similar activation patterns in the regions of sACC, DLPFC, VLPFC and IPL which were sensitive to either spontaneous truth-telling or lying.

  10. More Than Telling a Story: Transforming Data into Visually Shared Stories.

    Science.gov (United States)

    Lee, Bongshin; Riche, Nathalie Henry; Isenberg, Petra; Carpendale, Sheelagh

    2015-01-01

    The authors take a closer look at how the visualization community has discussed visual storytelling and present a visual data storytelling process, incorporating steps involved in finding insights (explore data), turning these insights into a narrative (make a story), and communicating this narrative to an audience (tell a story). They also discuss opportunities for future research in visualization as a storytelling medium in the light of this broader process.

  11. Analysis on the Hero's Abnormal Psychology in The tell-tale heart

    Institute of Scientific and Technical Information of China (English)

    王嘉维

    2009-01-01

    The Tell-Tale Heart is one of the horror stories of Edgar Allan Poe's,who was a master of the horror tale in American.The hero in this story is always afraid of the eyes of an old man.He is extreme anxiety under the eyes,for avoiding this anxiety,he kills the old n33n.This paper is to analyze the hero's abnormal psychology.

  12. Don't Ask, Don't Tell: A Costly and Wasteful Policy 

    OpenAIRE

    Barnes, Johnny L.

    2004-01-01

    Since the current policy known as "Don't Ask, Don't Tell" was adopted in the early 1990s, several changes have taken place which call into question the policy's validity. Firstly, the argument proponents of the ban use to justify it, namely that cohesion would suffer if admitted homosexuals were allowed to serve, has been undercut by social science analyses on the correlation between cohesion and performance. Their argument has also been undercut by empirical evidence from several nations tha...

  13. More Than Telling a Story: Transforming Data into Visually Shared Stories.

    Science.gov (United States)

    Lee, Bongshin; Riche, Nathalie Henry; Isenberg, Petra; Carpendale, Sheelagh

    2015-01-01

    The authors take a closer look at how the visualization community has discussed visual storytelling and present a visual data storytelling process, incorporating steps involved in finding insights (explore data), turning these insights into a narrative (make a story), and communicating this narrative to an audience (tell a story). They also discuss opportunities for future research in visualization as a storytelling medium in the light of this broader process. PMID:26416365

  14. Handbook on loss reserving

    CERN Document Server

    Schmidt, Klaus; Schnaus, Anja

    2016-01-01

    This handbook presents the basic aspects of actuarial loss reserving. Besides the traditional methods, it also includes a description of more recent ones and a discussion of certain problems occurring in actuarial practice, like inflation, scarce data, large claims, slow loss development, the use of market statistics, the need for simulation techniques and the task of calculating best estimates and ranges of future losses. In property and casualty insurance the provisions for payment obligations from losses that have occurred but have not yet been settled usually constitute the largest item on the liabilities side of an insurer's balance sheet. For this reason, the determination and evaluation of these loss reserves is of considerable economic importance for every property and casualty insurer. Actuarial students, academics as well as practicing actuaries will benefit from this overview of the most important actuarial methods of loss reserving by developing an understanding of the underlying stochastic models...

  15. Evaluation of blood loss after early or late release of ischemia in patients undergoing total knee replacement Avaliação da perda sanguínea após a liberação precoce ou tardia da isquemia em pacientes submetidos à artroplastia total do joelho

    Directory of Open Access Journals (Sweden)

    Marcos George de Souza Leão

    2013-04-01

    Full Text Available OBJECTIVE: compare blood loss in 40 patients underwent to unilateral total knee replacement with the release of ischemia before and after skin closure and compressive dressing. METHODS: in a prospective randomized study, in 40 patients underwent to total knee replacement, dividing then into two groups: group A in which the ischemia was released before skin closure, allowing bleeding control and group B where the ischemia was released after skin suture and pressure dressing. We compared the results of laboratory tests of serum hemoglobin before surgery and 48 hours postoperatively, the blood volume contained in vacuum suction drain and the transfusions that was necessary. RESULTS: As a result, the post operative serum hemoglobin levels had a mean decrease of 3.57 g/dL in group A and 4.24 g/dL in group B with an average of 0.67g/dL difference between them, statistically insignificant.The observed mean drainage, in the vacuum drain, were 705 mL in group A and 700 mL in group B. The 5ml difference between medians was considered statistically insignificant. The number of patients who received transfusions was four patients in both groups and all received two units of red blood cells. CONCLUSION: the post operative serum hemoglobin levels, as well as the need of blood transfusion, in the patient underwent to total knee replacement, where the ischemia was released before wound closure, has no statistical effect in comparison with patients where the sutures and bandages were done after the ischemia release. Level of Evidence IB - Individual randomized controlled trial with narrow confidence interval. OBJETIVO: Avaliar comparativamente a perda sanguínea em pacientes submetidos à artroplastia total do joelho, com liberação da isquemia antes e após suturas e curativo compressivo. MÉTODOS: Fez-se um estudo prospectivo randomizado em 40 pacientes submetidos à artroplastia total do joelho divididos em dois grupos. No primeiro grupo a isquemia foi

  16. The effects of punishment and appeals for honesty on children's truth-telling behavior.

    Science.gov (United States)

    Talwar, Victoria; Arruda, Cindy; Yachison, Sarah

    2015-02-01

    This study examined the effectiveness of two types of verbal appeals (external and internal motivators) and expected punishment in 372 children's (4- to 8-year-olds) truth-telling behavior about a transgression. External appeals to tell the truth emphasized social approval by stating that the experimenter would be happy if the children told the truth. Internal appeals to tell the truth emphasized internal standards of behavior by stating that the children would be happy with themselves if they told the truth. Results indicate that with age children are more likely to lie and maintain their lie during follow-up questioning. Overall, children in the External Appeal conditions told the truth significantly more compared with children in the No Appeal conditions. Children who heard internal appeals with no expected punishment were significantly less likely to lie compared with children who heard internal appeals when there was expected punishment. The results have important implications regarding the impact of socialization on children's honesty and promoting children's veracity in applied situations where children's honesty is critical. PMID:25447716

  17. Transitional Justice: History-Telling, Collective Memory, and the Victim-Witness

    Directory of Open Access Journals (Sweden)

    Chrisje Brants

    2013-06-01

    Full Text Available This article examines the complex, inherently political, and often contradictory processes of truth-finding, history-telling, and formation of collective memory through transitional justice. It explores tensions between history-telling and the normative goals of truth commissions and international criminal courts, taking into account the increasing importance attributed to victims as witnesses of history. The legal space these instruments of transitional justice offer is determined by both their historical and political roots, and specific goals and procedures. Because the legal space that truth commissions offer for history-telling ismore flexible and their report open to public debate, they may open up alternative public spaces and enable civil society to contest the master narrative. The legal truth laid down in the rulings of an international criminal court is by definition closed. The verdict of a court is definite and authoritative; closure, not continued debate about what it has established as the truth, is its one and only purpose. In conclusion, the article calls for a critical appraisal of transitional justice as acclaimed mediator of collective memories in post-conflict societies.

  18. The effects of punishment and appeals for honesty on children's truth-telling behavior.

    Science.gov (United States)

    Talwar, Victoria; Arruda, Cindy; Yachison, Sarah

    2015-02-01

    This study examined the effectiveness of two types of verbal appeals (external and internal motivators) and expected punishment in 372 children's (4- to 8-year-olds) truth-telling behavior about a transgression. External appeals to tell the truth emphasized social approval by stating that the experimenter would be happy if the children told the truth. Internal appeals to tell the truth emphasized internal standards of behavior by stating that the children would be happy with themselves if they told the truth. Results indicate that with age children are more likely to lie and maintain their lie during follow-up questioning. Overall, children in the External Appeal conditions told the truth significantly more compared with children in the No Appeal conditions. Children who heard internal appeals with no expected punishment were significantly less likely to lie compared with children who heard internal appeals when there was expected punishment. The results have important implications regarding the impact of socialization on children's honesty and promoting children's veracity in applied situations where children's honesty is critical.

  19. Medications and Blood Pressure

    Science.gov (United States)

    ... Blood Pressure Tools & Resources Stroke More Medications and Blood Pressure Updated:Jul 6,2016 When your blood pressure ... was last reviewed on 08/04/2014. High Blood Pressure • Home • About High Blood Pressure (HBP) • Why HBP ...

  20. Blood vessels, circulation and blood pressure.

    Science.gov (United States)

    Hendry, Charles; Farley, Alistair; McLafferty, Ella

    This article, which forms part of the life sciences series, describes the vessels of the body's blood and lymphatic circulatory systems. Blood pressure and its regulatory systems are examined. The causes and management of hypertension are also explored. It is important that nurses and other healthcare professionals understand the various mechanisms involved in the regulation of blood pressure to prevent high blood pressure or ameliorate its damaging consequences.

  1. Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.

    LENUS (Irish Health Repository)

    Murphy, Deirdre J

    2012-02-01

    BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at

  2. Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.

    LENUS (Irish Health Repository)

    Murphy, Deirdre J

    2009-01-01

    BACKGROUND: Caesarean section is one of the most commonly performed major operations in women throughout the world. Rates are escalating, with studies from the United States of America, the United Kingdom, China and the Republic of Ireland reporting rates between 20% and 25%. Operative morbidity includes haemorrhage, anaemia, blood transfusion and in severe cases, maternal death. The value of routine oxytocics in the third stage of vaginal birth has been well established and it has been assumed that these benefits apply to caesarean delivery as well. A slow bolus dose of oxytocin is recommended following delivery of the baby at caesarean section. Some clinicians use an additional infusion of oxytocin for a further period following the procedure. Intravenous oxytocin has a very short half-life (4-10 minutes) therefore the potential advantage of an oxytocin infusion is that it maintains uterine contractility throughout the surgical procedure and immediate postpartum period, when most primary haemorrhages occur. The few trials to date addressing the optimal approach to preventing haemorrhage at caesarean section have been under-powered to evaluate clinically important outcomes. There has been no trial to date comparing the use of an intravenous slow bolus of oxytocin versus an oxytocin bolus and infusion. METHODS AND DESIGN: A multi-centre randomised controlled trial is proposed. The study will take place in five large maternity units in Ireland with collaboration between academics and clinicians in the disciplines of obstetrics and anaesthetics. It will involve 2000 women undergoing elective caesarean section after 36 weeks gestation. The main outcome measure will be major haemorrhage (blood loss >1000 ml). A study involving 2000 women will have 80% power to detect a 36% relative change in the risk of major haemorrhage with two-sided 5% alpha. DISCUSSION: It is both important and timely that we evaluate the optimal approach to the management of the third stage at

  3. High Blood Pressure

    Science.gov (United States)

    ... normal blood pressure 140/90 or higher is high blood pressure Between 120 and 139 for the top number, ... prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. High ...

  4. Low Blood Glucose (Hypoglycemia)

    Science.gov (United States)

    ... Other Dental Problems Diabetic Eye Disease Low Blood Glucose (Hypoglycemia) What is hypoglycemia? Hypoglycemia, also called low ... actions can also help prevent hypoglycemia: Check blood glucose levels Knowing your blood glucose level can help ...

  5. Blood Clotting and Pregnancy

    Science.gov (United States)

    ... The risk of developing a blood clot during pregnancy is increased by the following: Previous blood clots A genetic predisposition to blood clots Obesity Prolonged immobility (e.g., bedrest, long distance travel) Multiple ...

  6. CEA blood test

    Science.gov (United States)

    Carcinoembryonic antigen blood test ... A blood sample is needed . ... When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. ...

  7. Ketones blood test

    Science.gov (United States)

    ... Ketones - serum; Nitroprusside test; Ketone bodies - serum; Ketones - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight ... there may be some throbbing or a slight bruise. This soon ...

  8. Magnesium blood test

    Science.gov (United States)

    Magnesium - blood ... A blood sample is needed. ... When the needle is inserted to draw blood, some people feel slight pain. Others feel a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon ...

  9. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... Blood Pressure Physical Activity High Blood Glucose My Health Advisor Tools To Know Your Risk Alert Day ... DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Step On Up Treatment & Care Blood Glucose Testing ...

  10. Blood Type Puzzle.

    Science.gov (United States)

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  11. High blood pressure - infants

    Science.gov (United States)

    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics . ...

  12. What Is Blood?

    Science.gov (United States)

    ... Our Member Blood Centers Our Partners What is blood? PUBLICATIONS EDUCATION PRESS ROOM BLOG CAREERS CONTACT ABC ... for patients who need it. One unit of blood can be separated into the following components: Nearly ...

  13. High Blood Pressure Facts

    Science.gov (United States)

    ... Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN High Blood Pressure Facts Recommend on Facebook Tweet Share Compartir ... facts about high blood pressure [PDF-255K] . High Blood Pressure in the United States About 70 million ...

  14. Blood Clotting and Pregnancy

    Medline Plus

    Full Text Available ... back to top How are Blood Clots in Pregnant Women Treated? Typically, blood clots are treated with ... you think you have one. If you are pregnant and have concerns about blood clots, talk with ...

  15. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... symptoms include the following: High blood glucose High levels of sugar in the urine Frequent urination Increased ... you should check and what your blood glucose levels should be. Checking your blood and then treating ...

  16. High Blood Pressure

    Science.gov (United States)

    ... pressure and should be taken seriously. Over time, consistently high blood pressure weakens and damages ... of landmark NIH blood pressure study confirm that lower blood pressure target can reduce ...

  17. Hereditary Hearing Loss.

    Science.gov (United States)

    Tran, LenhAnh P.; Grundfast, Kenneth M.

    1997-01-01

    This article discusses inheritance patterns in hearing loss, epidemiology, clues to genetic causes, locating genes that cause hereditary disorders, genes related to hearing loss disorders in individuals with Usher syndrome, Waardenburg syndrome, Treacher-Collins syndrome, Branchio-oto-renal and Pendred syndromes, and the significance of finding…

  18. Loss muinasjuturaamatust / Agu Veetamm

    Index Scriptorium Estoniae

    Veetamm, Agu, 1953-

    2004-01-01

    Ballindaloch on üks väheseid Shoti losse, kus omanikud aastaringselt elavad. 450 aastat on loss kuulunud Macpherson-Grantide suguvõsale. Praegu on lossi omanikuks Clare Nancy Macpherson-Grant Russell, kelle kujundatud on kiviktaimla ja rosaarium. Lossi ajaloost, omanikest, ümberehitustest, ringkäigust lossis, pargist. 14 ill

  19. Loss Tolerant Optical Qubits

    CERN Document Server

    Ralph, T C; Gilchrist, A; Gilchrist, Alexei

    2005-01-01

    We present a linear optics quantum computation scheme that employs a new encoding approach that incrementally adds qubits and is tolerant to photon loss errors. The scheme employs a circuit model but uses techniques from cluster state computation and achieves comparable resource usage. To illustrate our techniques we describe a quantum memory which is fault tolerant to photon loss.

  20. Help! It's Hair Loss!

    Science.gov (United States)

    ... Homework? Here's Help White House Lunch Recipes Help! It's Hair Loss! KidsHealth > For Kids > Help! It's Hair Loss! Print A A A Text Size ... part above the skin, is dead. (That's why it doesn't hurt to get a haircut!) This ...

  1. Money for Blood and Markets for Blood.

    Science.gov (United States)

    Derpmann, Simon; Quante, Michael

    2015-12-01

    Ontario's Bill 178 proposing a Voluntary Blood Donations Act declares the offer or acceptance of payment for the donation of blood a legal offence and makes it subject to penalty. The bill reinvigorates a fundamental debate about the ethical problems associated with the payment of money for blood. Scarcity of blood donors is a recurring problem in most health systems, and monetary remuneration of the willingness to donate blood is regularly discussed--and sometimes practiced--as a means to overcome scarcity in blood. However, making blood an object of economic exchange has long aroused ethical concerns that often refer to the specific meaning of blood. From the perspective of a modern understanding of money as a metric of economic value, the exchange of money for blood--shed or given--is seen as ethically troubling, because it appears to imply a commensurability of the value of human life and economic wealth. In this paper, we begin with a general taxonomy of the types of arguments that speak in favour or against compensating donors for giving blood. We then describe the context in which the discussion about payment for blood arises, and of the specific aims and concerns that are brought forward in this context. This is used to reconstruct the normative background that supports the rejection of payment for blood as it is envisaged in Bill 178 and the aims of the proposal. We then argue that while a payment indeed changes the nature of a blood donation in an ethically considerable way, we do not believe that decisive arguments against the monetary remuneration of blood donations can be substantiated, at least not independently of assuming specific societal circumstances. Thus it may be possible to establish a stable and safe blood supply through just gratification while at the same time taking strong provisions against social disconnection, injustice, exploitation or heteronomy.

  2. [Inner Ear Hearing Loss].

    Science.gov (United States)

    Hesse, G

    2016-06-01

    Hearing loss is one of the most dominant handicaps in modern societies, which additionally very often is not realized or not admitted. About one quarter of the general population suffers from inner ear hearing loss and is therefore restricted in communicational skills. Demographic factors like increasing age play an important role as well as environmental influences and an increasing sound and noise exposure especially in leisure activities. Thus borders between a "classical" presbyacusis - if it ever existed - and envirionmentally induced hearing loss disappear. Today restrictions in hearing ability develop earlier in age but at the same time they are detected and diagnosed earlier. This paper can eventually enlighten the wide field of inner ear hearing loss only fragmentarily; therefore mainly new research, findings and developments are reviewed. The first part discusses new aspects of diagnostics of inner ear hearing loss and different etiologies. PMID:27259171

  3. 氨甲环酸静脉滴注联合关节腔注射对初次全膝关节置换患者术后出血量的影响%Effects of intravenous and intra - articular tranexamic acid on postoperative blood loss of primary total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    王英明; 孔荣; 禹德万; 朱晨

    2015-01-01

    目的:探讨氨甲环酸静脉滴注联合关节腔注射对初次行全膝关节置换患者术后出血量的影响。方法以2015年1月至2015年5月收治的45例重度膝骨关节炎行初次全膝关节置换的患者为研究对象,随机分为氨甲环酸组(23例)与对照组(22例)。氨甲环酸组术中松止血带前30 min 静脉应用氨甲环酸10 mg/ kg,并于手术结束后经引流管向关节腔注射1.0 g 氨甲环酸,夹闭引流管4 h,弹力绷带包扎。对照组的处理为给予相应量的生理盐水。观察两组患者术后24 h、48 h 引流量并于术后第3天复查血常规。结果氨甲环酸组术后切口引流量平均约220 mL,与对照组450 mL 相比,差异有统计学意义(P <0.05)。术后第3天复查血红蛋白的降低程度,氨甲环酸组降低约12.9 g/ L,明显小于对照组23.5 g/ L,且差异有统计学意义(P <0.05)。结论氨甲环酸静脉滴注联合关节腔注射可以明显降低初次全膝关节置换患者术后出血量。%Objective To investigate the effect of intravenous and intra-articular tranexamic acid on postoperative blood loss of pri-mary total knee arthroplasty(TKA). Methods From Jan 2015 to May 2015,45 patients who received primary TKA due to severe knee os-teoarthritis were randomly allocated to tranexamic acid(TA)group(n = 23)and control group(n = 22). Patients in the TA group received intravenous tranexamic acid 10 mg/ kg at 30 min before tourniquet release and 1. 0 g tranexamic acid intra-articular injection through the drain tube rightly after wound closure,followed by drain tube clip for 4 hours and pressured elastic bandage. The corresponding amount of saline was administered in the control group. The volume of drainage was recorded at 24 and 48 hours after operation,and haemoglobin level was in-spected again at 3 days after operation. Results Compared with 450 ml drainage fluid in the control group,the mean volume of drainage

  4. Aspirin and local application of tranexamic acid reduce blood loss for simultaneous bilateral total knee arthroplasty%双侧同期全膝关节置换术患者阿司匹林结合氨甲环酸局部应用有效性与安全性的回顾研究

    Institute of Scientific and Technical Information of China (English)

    顾建明; 潘盈; 杜辉; 蒋毅; 周一新

    2016-01-01

    目的:研究阿司匹林结合关节腔内应用氨甲环酸在减少同期双侧人工全膝关节置换术围手术期出血的有效性和安全性。方法将2012年1月至2015年1月,同期行双侧人工全膝置换术患者101例分为观察组与对照组。45例未使用氨甲环酸为对照组,使用氨甲环酸的56例为观察组。观察组患者在骨水泥固定后关节内喷洒氨甲环酸1 g (10 ml )。术后使用阿司匹林预防静脉血栓。记录两组患者的性别,男女比例,体重指数,术前血容量,术前血红蛋白水平以及血小板计数,再比较两组患者术后总失血量、有无输血、输血量以及有无症状性静脉栓塞( VTE )发生。结果氨甲环酸组和对照组在术后第1天总失血量分别为729.0 ml 和1163.0 ml,术后第5天总失血量为915.8 ml 和1358.2 ml,总输血量3.1 U 和4.2 U,输血率为92.9%和100.0%,观察组数据显著低于对照组(P<0.05)。观察组术后第5天的血红蛋白水平(1108 g / L )明显高于对照组(982 g / L )(P<0.05)。两组患者术后血小板计数[(159.4±44.4)×109/ L 和(165.4±45.7)×109/ L ]差异无统计学意义(P>0.05)。两组患者术后均未发生症状性静脉血栓。结论同期双侧人工全膝关节置换术局部使用氨甲环酸可以有效减少出血量,且不增加血栓发生风险。%Objective To investigate the efifcacy and safety of aspirin in combination with local tranexamic acid for simultaneous bilateral total knee arthroplasty.Methods From Jan. 2012 to Jan. 2015, 101 simultaneous bilateral TKA were retrospectively analyzed. Local application of tranexamic acid was given in 56 cases. Control group involved 45 cases without tranexamic acid uses. Aspirin was given for prevention of deep vein thrombosis. Total blood loss, transfusion volume, transfusion rate and venous thromboembolism were recorded and compared.Results Total blood loss in post-operative day one and ifve, transfusion volume

  5. B族维生素及同型半胱氨酸与复发性流产的关系%Correlation between serum FA, VitB12, HCY and red blood cell FA level in patients with early unexplained recurrent pregnancy loss

    Institute of Scientific and Technical Information of China (English)

    林晓娟; 董雪梅; 柳素芬; 孙庆梅; 赵翠生; 张翀; 杜晓钟; 孙朋; 刘青

    2012-01-01

    目的 测定血清叶酸、维生素B12、同型半胱氨酸及红细胞叶酸水平,探讨其与早期原因不明复发性流产的关系.方法 分别采用磁微粒酶免疫分析方法、ELISA方法及电化学发光法测定流产组与对照组外周血中血清叶酸、维生素B12、同型半胱氨酸及红细胞叶酸水平.结果 76例早期原因不明复发性流产患者(流产组)与40例正常同期育龄期妇女(对照组)比较,血清叶酸( t=-3.631,P<0.005)、维生素B12(t=-4.790,P<0.005)、同型半胱氨酸(t=3.019,P<0.005)及红细胞叶酸(t=-3.640,P<0.005),均有显著性差异.流产组A组(补充0.4mg/d叶酸片)与B组(补充5mg/d叶酸片及复合维生素B),2组补充叶酸后1个月与首诊比较,血清叶酸(t=2.131,P<0.005)及同型半胱氨酸(t=2.685,P<0.05),均有显著性差异.结论 体内叶酸水平低下可能是早期原因不明复发性流产发生、发展的一个重要因素,它的检测对于早期原因不明复发性流产患者的预防及治疗具有一定的临床意义.%Objective To determine the serum levels of folic acid, vitamin B12 , homocysteine ( HCY ) and red blood cell folic acid and explore the correlation between them and early unexplained recurrent pregnancy loss ( URPL ). Methods The serum levels of serum folic acid, vitamin B12, HCY and red blood cell folic acid in abortion group and control group were measured by magnetic beads enzyme immunoassay, enzyme linked immunosorbent assay ( ELISA ) and electrochemiluminescence assay ( ECLA ) methods, respectively. Results The mean levels of serum folic acid, vitamin B12 , HCY and red blood cell folic acid were significantly different between 76 cases of URPL ( abortion group ) and 40 cases of simultaneous women of childbearing age ( control group )( t value was - 3. 631, - 4. 790, 3.019and -3.640, respectively, allP<0.005). Compared with the levels of serum folic acid and HCY at initial diagnosis, they were significantly different one

  6. Is Sudden Hearing Loss Associated with Atherosclerosis?

    Directory of Open Access Journals (Sweden)

    Mohsen Rajati

    2016-05-01

    Full Text Available Introduction: Sudden sensorineural hearing-loss (SSNHL patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients.   Materials and Methods: Thirty SSNHL patients and 30 controls were evaluated with regard to cardiovascular risks including history, heart examination, blood pressure, body mass index, waist circumference, electrocardiogram, blood sugar, triglycerides, cholesterol, high-sensitivity C-reactive protein (HSCRP; also, carotid artery color Doppler study was undertaken to measure intima media thickness(IMT.   Results: IMT and HSCRP showed an increased risk in the case group compared with the controls (P= 0.005 & P=0.001. However, waist circumference, history of smoking, fasting blood sugar, lipid profile, and electrocardiogram revealed no significant difference between the two groups. Interestingly, blood pressure and body mass index were higher in the controls in this study.   Conclusion:  Sudden sensorineural hearing loss may be associated with subclinical atherosclerosis.

  7. Is Sudden Hearing Loss Associated with Atherosclerosis?

    Science.gov (United States)

    Rajati, Mohsen; Azarpajooh, Mahmoud Reza; Mouhebati, Mohsen; Nasrollahi, Mostafa; Salehi, Maryam; Khadivi, Ehsan; Nourizadeh, Navid; Hashemi, Firoozeh; Bakhshaee, Mehdi

    2016-01-01

    Introduction: Sudden sensorineural hearing-loss (SSNHL) patients constitute approximately 2–3% of referrals to ear, nose and throat (ENT) clinics. Several predisposing factors have been proposed for this condition; one of which is vascular disorders and perfusion compromise. In this research the atherosclerotic changes and their known risk factors are studied in SSNHL patients. Materials and Methods: Thirty SSNHL patients and 30 controls were evaluated with regard to cardiovascular risks including history, heart examination, blood pressure, body mass index, waist circumference, electrocardiogram, blood sugar, triglycerides, cholesterol, high-sensitivity C-reactive protein (HSCRP); also, carotid artery color Doppler study was undertaken to measure intima media thickness(IMT). Results: IMT and HSCRP showed an increased risk in the case group compared with the controls (P= 0.005 & P=0.001). However, waist circumference, history of smoking, fasting blood sugar, lipid profile, and electrocardiogram revealed no significant difference between the two groups. Interestingly, blood pressure and body mass index were higher in the controls in this study. Conclusion: Sudden sensorineural hearing loss may be associated with subclinical atherosclerosis. PMID:27429947

  8. Blood transfusion practices in obstetric anaesthesia

    Directory of Open Access Journals (Sweden)

    Ashok Jadon

    2014-01-01

    Full Text Available Blood transfusion is an essential component of emergency obstetric care and appropriate blood transfusion significantly reduces maternal mortality. Obstetric haemorrhage, especially postpartum haemorrhage, remains one of the major causes of massive haemorrhage and a prime cause of maternal mortality. Blood loss and assessment of its correct requirement are difficult in pregnancy due to physiological changes and comorbid conditions. Many guidelines have been used to assess the requirement and transfusion of blood and its components. Infrastructural, economic, social and religious constraints in blood banking and donation are key issues to formulate practice guidelines. Available current guidelines for transfusion are mostly from the developed world; however, they can be used by developing countries keeping available resources in perspective.

  9. 47 CFR 95.423 - (CB Rule 23) What must I do if the FCC tells me that my CB station is causing interference?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (CB Rule 23) What must I do if the FCC tells me...) Radio Service Other Things You Need to Know § 95.423 (CB Rule 23) What must I do if the FCC tells me that my CB station is causing interference? (a) If the FCC tells you that your CB station is...

  10. 47 CFR 95.220 - (R/C Rules 20) What must I do if the FCC tells me that my R/C station is causing interference?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (R/C Rules 20) What must I do if the FCC tells.../C) Radio Service Other Things You Need to Know § 95.220 (R/C Rules 20) What must I do if the FCC tells me that my R/C station is causing interference? (a) If the FCC tells you that your R/C station...

  11. Transfusion of blood and blood component therapy for postpartum haemorrhage at a tertiary referral center

    International Nuclear Information System (INIS)

    Objective: To determine the practice of transfusion of blood and blood products in cases of postpartum haemorrhage, at a tertiary referral center. Methods: A retrospective study was conducted where medical records were reviewed for women, who either delivered or were admitted in labour suite with diagnosis of postpartum haemorrhage. The study period extended from Jan 2008 to Oct 2009. During a period of 22 months, records were reviewed for transfusion of blood and blood products in above group of women. Data were analyzed for descriptive statistics. Results: During the study period, a total of 4744 patients were admitted in the labour suite. A total of 113 (2.36%) women were diagnosed with Post partum haemorrhage. Uterine atony was the commonest cause of PPH, followed by genital tract trauma. A total of 81(71%) women received transfusion of blood and blood components (1.6%). The mean blood loss was 1088 ml (+- 584ml). Transfusion of blood and blood component therapy was significantly more in women who underwent caesarean section, compared to those women who delivered vaginally. There was one case of acute tubular necrosis due to PPH, and seven maternal deaths. The mean hospital stay was of +- 3 days. Conclusion: In this hospital based study, the prevalence of PPH was 2.36 +- %, and the rate of transfusion of blood and blood products was 1.6%.

  12. Sudden sensorineural hearing loss.

    Science.gov (United States)

    Stew, B T; Fishpool, S J C; Williams, H

    2012-02-01

    Sudden onset sensorineural hearing loss is a medical emergency that continues to be poorly understood despite being recognized in the literature since 1944 (De Kleyn, 1944). A commonly used criterion to qualify for this diagnosis is a sensorineural hearing loss over three contiguous pure-tone frequencies of 30 dB or more that develops within 72 hours. The vast majority of cases are unilateral and the estimated annual incidence is 20 per 100 000 persons (Nosrati-Zarenoe et al, 2007). A cause for the hearing loss is only identified in up to 10% of cases but 50% of patients will improve spontaneously (Penido et al, 2009).

  13. What Can I Do About Smell Loss?

    Medline Plus

    Full Text Available ... you've been having some problems with your nose and sinuses. Tell me a little bit about ... of smell. Dr. Oringer: Difficulty breathing through your nose with that? Maryann: In the beginning, yes. But ...

  14. Red blood cell replacement, or nanobiotherapeutics with enhanced red blood cell functions?

    Science.gov (United States)

    Chang, Thomas Ming Swi

    2015-06-01

    Why is this important? Under normal circumstances, donor blood is the best replacement for blood. However, there are exceptions: During natural epidemics (e.g., HIV, Ebola, etc.) or man-made epidemics (terrorism, war, etc.), there is a risk of donor blood being contaminated, and donors being disqualified because they have contracted disease. Unlike red blood cells (RBCs), blood substitutes can be sterilized to remove infective agents. Heart attack and stroke are usually caused by obstruction of arterial blood vessels. Unlike RBCs, which are particulate, blood substitutes are in the form of a solution that can perfuse through obstructed vessels with greater ease to reach the heart and brain, as has been demonstrated in animal studies. Severe blood loss from injuries sustained during accidents, disasters, or war may require urgent blood transfusion that cannot wait for transportation to the hospital for blood group testing. Unlike RBCs, blood substitutes do not have specific blood groups, and can be administered on the spot. RBCs have to be stored under refrigeration for up to 42 days, and are thus difficult to transport and store in times of disaster and at the battlefront. Blood substitutes can be stored at room temperature for more than 1 year, compared to the RBC shelf life of 1 day, at room temperature. In cases of very severe hemorrhagic shock, there is usually a safety window of 60 min for blood replacement, beyond which there could be problems related to irreversible shock. Animal studies show that a particular type of blood substitute, with enhanced RBC enzymes, may be able to prolong the duration of the safety window. PMID:26096663

  15. 冷冻氨甲环酸注射液对全膝关节表面置换术后失血量的影响%Effect of frozen tranexamic acid injection on the blood loss after total knee arthroplasty

    Institute of Scientific and Technical Information of China (English)

    马涛; 朱云; 李毓灵; 杨刚; 王正宇; 张健

    2015-01-01

    目的:探讨全膝关节表面置换术(total knee arthroplasty,TKA)后关节腔内灌注冷冻氨甲环酸注射液对术后失血量的影响.方法:健康成年新西兰大白兔(雌雄未分)45只,按照随机分组的方法分为3组,建立TKA模型,术毕关节腔内留置引流管,逐层缝合切口,通过引流管向兔膝关节腔内分别注入A组:冷冻生理盐水注射液3 ml(0℃);B组:常温氨甲环注射液3ml(30 mg/ml);C组:冷冻氨甲环酸注射液3 ml(30 mg/ml,0℃).术后引流管夹闭4h后开放行持续负压引流,术后24h拔除引流管,记录各实验对象术后切口的引流量及术后第3d血红蛋白(hemoglobin,Hb)的下降幅度.结果:术后24 h,3组实验对象切口引流量分别为A组(9.61±1.31) ml,B组(6.37±1.25) ml,C组(4.13±0.88) ml,C组术后平均引流量明显少于A组(P=0.000)和B组P=0.000)术后的切口引流量;术后第3d3组实验对象的Hb下降幅度分别为A组(22.80±3.23) g/L,B组(17.73±4.16) g/L,C组(13.80±3.82) g/L,C组术后第3天的Hb下降幅度明显低于A组(P=0.000)和B组(P=0.006)的Hb下降幅度.结论:兔膝TKA术后关节腔内灌注冷冻氨甲环酸注射液较常温氨甲环酸注射液相比,更能够有效减少术后引流量和术后Hb的下降幅度.%Objective:To study the effects of using frozen tranexamic acid for intra-articular injection on blood loss after total knee arthroplasty(TKA).Methods:Totally 45 New Zealand white rabbits unsexed were randomly divided into 3 groups to build the TKA operation model.After operation,a drainage tube was placed in the articular cavity,then the incision was sutured.Different solutions were injected in articular cavity in 3 groups by drainage tubes:in group A,normal ice normal saline 3 ml(0 ℃);in group B,normal temperature tranexamic acid 3 ml (concentration of 30 mg/ml);in group C:frozen tranexamic acid 3 ml(concentration of 30 mg/ml,0 ℃).The drainage tube was clamped for 4 h,then opened to keep continuous vacuum aspiration

  16. What's Hearing Loss?

    Science.gov (United States)

    ... cochlea during an operation. It takes over the job of the damaged or destroyed hair cells in the ... and Communicating A kid with hearing loss may attend a special school, special classes within ...

  17. Prizes for weight loss.

    OpenAIRE

    Englberger, L

    1999-01-01

    A programme of weight loss competitions and associated activities in Tonga, intended to combat obesity and the noncommunicable diseases linked to it, has popular support and the potential to effect significant improvements in health.

  18. Understanding Grief and Loss

    Science.gov (United States)

    ... Other common behaviors include restlessness and excessive activity. Religion and spirituality Grief and loss may also cause ... The grieving person’s age and gender The life history of the person who is grieving, including previous ...

  19. Weight loss - unintentional

    Science.gov (United States)

    ... urinating more than usual? Have you lost any hair? What medicines are you taking? Do you feel sad or depressed? Are you pleased or concerned with the weight loss? You may need to see a dietitian for nutrition advice.

  20. Prizes for weight loss.

    Science.gov (United States)

    Englberger, L.

    1999-01-01

    A programme of weight loss competitions and associated activities in Tonga, intended to combat obesity and the noncommunicable diseases linked to it, has popular support and the potential to effect significant improvements in health. PMID:10063662

  1. Bone Loss in IBD

    Science.gov (United States)

    ... DENSITY? Although bone seems as hard as a rock, it’s actually living tissue. Throughout your life, old ... available Bone Loss (.pdf) File: 290 KB 733 Third Avenue, Suite 510, New York, NY 10017 | 800- ...

  2. Types of Hearing Loss

    Science.gov (United States)

    ... on this topic can be found in our Audiology Information Series [PDF]. Hearing loss can be categorized ... speech-language pathologists; speech, language, and hearing scientists; audiology and speech-language pathology support personnel; and students. ...

  3. BUN - blood test

    Science.gov (United States)

    Blood urea nitrogen ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... Many medicines can interfere with blood test results. Your health ... if you need to stop taking any medicines before you have this ...

  4. Hyperglycemia (High Blood Glucose)

    Medline Plus

    Full Text Available ... how often you should check and what your blood glucose levels should be. Checking your blood and then treating ... I Treat Hyperglycemia? You can often lower your blood glucose level by exercising. However, if your blood glucose is ...

  5. Prospective comparative research on the blood loss after total knee arthroplasty be-tween single dose intraarticular injection of tranexamic acid and during operation and postoperative injection of tranexamic acid%氨甲环酸应用方式对膝关节置换围手术期失血量影响对照研究

    Institute of Scientific and Technical Information of China (English)

    华政哲; 张敬东; 韩文峰; 何勇; 张攀; 孙保飞

    2016-01-01

    Objective To compare the efficiency of single dose intra-articular injection of tranexamic acid( TXA) and during operation and postoperative injection of tranexamic acid on the blood loss after total knee arthroplasty( TKA) . Meth-ods A total of 68 patients with osteoarthritis of knee joint,who were performed TKA,were prospective analyzed. Due to the TXA control method,patients were random divided into two groups including single dose intra-articular injection of tranex-amic acid group(Group A)and in operation and postoperative injection of tranexamic acid group(Group B). In Group A, 2. 5 g tranexamic acid was intra-articular injected after skin suture. In Group B,1. 0 g tranexamic acid was injected to femo-ral medullary cavity in operation,and the other 1. 5 g tranexamic acid was intra-articular injected after skin suture. All oper-ations in the two groups were performed by the same surgeon,and the same knee joint prosthesis. The data of hemoglobin, operation time,drainage blood and total blood loss after TKA were analyzed. Results There were no significant difference between two groups with respect of age,gender,body mass index. At 24 hours postoperatively,the hemoglobin in Group A was(11. 2 ± 0. 9)g/L,and(11. 9 ± 0. 8)g/L in Group B,and there was significant difference between the two groups. At 48 hours postoperatively,the hemoglobin of Group A was(10. 5 ± 1. 0) g/L,and that was(11. 3 ± 0. 6) g/L in Group B,and there was significant difference between the two groups. The postoperative drainage volume was(320. 5 ± 21. 0)ml in Group A and(260. 9 ±18. 7)ml in Group B,and there was significant difference between the two groups(P<0. 01). The total blood loss was(962. 0 ±43. 6)ml in Group A and(780. 0 ±42. 3)ml in Group B,and there was also significant difference between the two groups(P<0. 01). No case suffered from deep vein thrombosis and other complications in both groups. Conclusion Combined with intraoperative and postoperative injection of tranexamic

  6. Female Pattern Hair Loss

    OpenAIRE

    Herskovitz, Ingrid; Tosti, Antonella

    2013-01-01

    Context: Female pattern hair loss (FPHL) also known as female androgenetic alopecia is a common condition afflicting millions of women that can be cosmetically disrupting. Prompt diagnosis and treatment are essential for obtaining optimal outcome. This review addresses the clinical presentation of female pattern hair loss, its differential diagnosis and treatment modalities. Evidence Acquisition: A) Diffuse thinning of the crown region with preservation of the frontal hairline (Ludwig’s type)...

  7. Archaeological record of earthquake ruptures in Tell Ateret, the Dead Sea Fault

    Science.gov (United States)

    Ellenblum, Ronnie; Marco, Shmuel; Kool, Robert; Davidovitch, Uri; Porat, Roi; Agnon, Amotz

    2015-10-01

    The archaeological Tell Ateret (North Israel), constructed on the active Dead Sea Fault, was intermittently settled for over six millennia. Structures on the Tell that have been offset by earthquake ruptures provide a remarkable record of alternating construction and slip. We excavated the site in order to resolve the geometry and to time the earthquake rupture history back to the earliest settlement. The measurements of faulted archaeological walls are complemented with data from historical documents, numismatic analysis, and geological observations. We report three newly discovered offsets that add to two previously resolved slip events (the 20 May 1202 and 30 October 1759 earthquakes), completing a three millennia archaeoseismic record. The oldest offset measuring at least ~2 m bisected Iron Age IIA fortifications. The second offset, the largest of all five, reaching ~2.5 m, is dated to circa 142 BCE The third, whose post-Hellenistic date is not determined, is of ~1.5 m, possibly resulting from multiple earthquakes. We constrain the time of the largest offset by a hoard of 45 coins, the latest of which had been minted 143/142 BCE. Indicative pottery and historic texts support the year 143/142 as terminus post-quem of the rupture at this site. These observations, together with a new kinematic approach, show uneven slip distribution in time and variable amounts of slip along the Jordan Gorge segment of the Dead Sea Fault. We suggest, based on previous palaeomagnetic measurements, that distributed deformation west of Tell Ateret can explain the apparent missing slip of 4.5 ± 3.5 m since the Hellenistic times.

  8. TellTable Spreadsheet Audit: from Technical Possibility to Operating Prototype

    CERN Document Server

    Nash, John; Smith, Neil

    2008-01-01

    At the 2003 EuSpRIG meeting, we presented a framework and software infrastructure to generate and analyse an audit trail for a spreadsheet file. This report describes the results of a pilot implementation of this software (now called TellTable; see www.telltable.com), along with developments in the server infrastructure and availability, extensions to other "Office Suite" files, integration of the audit tool into the server interface, and related developments, licensing and reports. We continue to seek collaborators and partners in what is primarily an open-source project with some shared-source components.

  9. Time telling devices used in Danish health care are not synchronized

    DEFF Research Database (Denmark)

    Brabrand, Mikkel; Hosbond, Susanne; Petersen, Dan Brun;

    2012-01-01

    Many patients begin their encounter with the health-care services in an ambulance. In some critical patients, it is pivotal that the timing of treatment and events is registered correctly. When patients are transferred from one health care provider to another, there is a risk that the time tellin...... devices used are not synchronized. It has never been examined if this is a problem in Denmark. We performed the present study to examine if time telling devices used in the pre-hospital setting were synchronized with devices used in emergency departments....

  10. ‘..there is so much to tell now, really now'

    DEFF Research Database (Denmark)

    Balle, Søren Hattesen

    2008-01-01

    of scepticism towards continuous narrative left by modernist poetics and its emphasis on the lyrical or epiphanic moment, postmodern poetry’s reinvestment in storytelling is never made in perfectly good faith. So, if postmodern poets tell stories, they only do so by “allud[ing] to story” or “foreground...... of the classical novel. Yet, and this will be my main claim, Ashbery’s poetic stories are never quite straightforward. Often they are interspersed with odd narrative details that call attention to themselves as what appears to be a straight story’s ‘queer moments’. Thus, I shall argue that Ashbery combines...

  11. An Analysis of the Unreliable Narrator in The Tell-Tale Heart

    Institute of Scientific and Technical Information of China (English)

    QIN Jiang-li

    2015-01-01

    The Tell-Tale Heart is a short story by Edgar Allan Poe. The story is first-person narrative of a narrator who murdered an old man with a clouded eye. This paper aims at identifying the speaker“I”as an unreliable narrator through analyzing the mo⁃tivation, process and confession of the crime. It is found out that the narrator symbolizes man of evil, while, the old man ’s vul⁃ture eye symbolizes virtue. It’s a story about the conflict between evil and virtue.

  12. TWO RHODIAN STAMPED AMPHORA HANDLES FROM TELL ES-SUKHNAH (JORDAN): A CASE STUDY

    OpenAIRE

    Ali, Nabil; Bader, Nabil

    2015-01-01

    During recent excavations at the archaeological site of Tell Es-Sukhnah in north east Jordan, an in-situ Rohdian amphora was found. The most important thing about that amphora is that both handles are carrying stamps in Greek scripts. The texts contain the name of an eponym, a Rhodian month-name and the fabricant’s name. Similar objects in the southern Levant enable dating the stamps to the second century B.C. The imported Amphora at Es-Sukhnah, besides other small finds, highlights the...

  13. Analytical investigations of cooking pottery from Tell Beydar (NE-Syria)

    International Nuclear Information System (INIS)

    Within the framework of a technological and socio-economical study of pottery production in Tell Beydar (NE-Syria) during the third millennium BC, the chemical composition and mineralogy of cooking pottery from that site has been studied using polarizing microscopy, scanning electron microscopy with energy dispersive X-ray detection (SEM-EDX) and X-ray diffraction by means of synchrotron radiation (SR-XRD). The obtained data were used to make inferences concerning the pottery's technology, such as clay preparation and firing techniques

  14. A case of sudden unilateral sensorineural hearing loss with contralateral psychogenic hearing loss induced by gunshot noise.

    Science.gov (United States)

    Hong, Young-Ho; Mun, Seog-Kyun

    2011-10-01

    The reasons behind sudden sensorineural hearing loss are mostly unknown, but viral infections, blood disorders, ototoxicity, noise trauma, autoimmune disease, acoustic tumor, and even mental stress may be related to the disease. In cases of hearing loss as a result of psychogenic factors, early diagnosis and adequate treatment under collaboration with the psychiatric department are crucial, since failure to take appropriate measures may result in permanent sequela. We report a case, with a review of the literature, of sudden unilateral sensorineural hearing loss with contralateral psychogenic hearing loss induced by gunshot noise.

  15. Loss Allocation in Securitization Transactions

    OpenAIRE

    Günter Franke; Markus Herrmann; Thomas Weber

    2011-01-01

    This paper analyses the loss allocation to First, Second and Third Loss Positions in European collateralized debt obligation transactions. The quality of the underlying asset pool plays a predominant role for the loss allocation. A lower asset pool quality induces the originator to take a higher First Loss Position, but, in a synthetic transaction, a smaller Third Loss Position. The share of expected default losses, borne by the First Loss Position, is largely independent of asset pool qualit...

  16. Blood Vessels in Allotransplantation.

    Science.gov (United States)

    Abrahimi, P; Liu, R; Pober, J S

    2015-07-01

    Human vascularized allografts are perfused through blood vessels composed of cells (endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are thus subject to host alloimmune responses. Graft vessels must be healthy to maintain homeostatic functions including control of perfusion, maintenance of permselectivity, prevention of thrombosis, and participation in immune surveillance. Vascular cell injury can cause dysfunction that interferes with these processes. Graft vascular cells can be activated by mediators of innate and adaptive immunity to participate in graft inflammation contributing to both ischemia/reperfusion injury and allograft rejection. Different forms of rejection may affect graft vessels in different ways, ranging from thrombosis and neutrophilic inflammation in hyperacute rejection, to endothelialitis/intimal arteritis and fibrinoid necrosis in acute cell-mediated or antibody-mediated rejection, respectively, and to diffuse luminal stenosis in chronic rejection. While some current therapies targeting the host immune system do affect graft vascular cells, direct targeting of the graft vasculature may create new opportunities for preventing allograft injury and loss. PMID:25807965

  17. Telling Stories

    Science.gov (United States)

    Mathematics Teaching, 2010

    2010-01-01

    Every year the Institute of Mathematics Pedagogy meet for a residential conference in July working together to focus on particular aspects of teaching and learning mathematics. The conference is open to all, and includes all sorts of people involved in mathematics and education. This year the focus was on proof and narrative. This article looks at…

  18. Telling tails

    OpenAIRE

    Kennedy, Mary B; Manzerra, Pat

    2001-01-01

    The N-methyl-D-aspartate (NMDA)-type glutamate receptor is one of three major classes of receptors for glutamate, the principle excitatory neurotransmitter in the central nervous system. It plays a key role in learning and in the formation of memories by acting as a "coincidence detector" that initiates changes in synaptic strength that lead to the formation of new neural networks (1). It is also an important mediator of several forms of pathological neuronal toxicity. The NMDA receptor respo...

  19. Influence of gear loss factor on the power loss prediction

    OpenAIRE

    C. M. C. G. Fernandes; P. M. T. Marques; R. C. Martins; J. H. O. Seabra

    2015-01-01

    In order to accurately predict the power loss generated by a meshing gear pair the gear loss factor must be properly evaluated. Several gear loss factor formulations were compared, including the author's approach. A gear loss factor calculated considering the load distribution along the path of contact was implemented. The importance of the gear loss factor in the power loss predictions was put in evidence comparing the predictions with experimental results. It was ...

  20. Weight Loss Nutritional Supplements

    Science.gov (United States)

    Eckerson, Joan M.

    Obesity has reached what may be considered epidemic proportions in the United States, not only for adults but for children. Because of the medical implications and health care costs associated with obesity, as well as the negative social and psychological impacts, many individuals turn to nonprescription nutritional weight loss supplements hoping for a quick fix, and the weight loss industry has responded by offering a variety of products that generates billions of dollars each year in sales. Most nutritional weight loss supplements are purported to work by increasing energy expenditure, modulating carbohydrate or fat metabolism, increasing satiety, inducing diuresis, or blocking fat absorption. To review the literally hundreds of nutritional weight loss supplements available on the market today is well beyond the scope of this chapter. Therefore, several of the most commonly used supplements were selected for critical review, and practical recommendations are provided based on the findings of well controlled, randomized clinical trials that examined their efficacy. In most cases, the nutritional supplements reviewed either elicited no meaningful effect or resulted in changes in body weight and composition that are similar to what occurs through a restricted diet and exercise program. Although there is some evidence to suggest that herbal forms of ephedrine, such as ma huang, combined with caffeine or caffeine and aspirin (i.e., ECA stack) is effective for inducing moderate weight loss in overweight adults, because of the recent ban on ephedra manufacturers must now use ephedra-free ingredients, such as bitter orange, which do not appear to be as effective. The dietary fiber, glucomannan, also appears to hold some promise as a possible treatment for weight loss, but other related forms of dietary fiber, including guar gum and psyllium, are ineffective.

  1. Automated decoding of facial expressions reveals marked differences in children when telling antisocial versus prosocial lies.

    Science.gov (United States)

    Zanette, Sarah; Gao, Xiaoqing; Brunet, Megan; Bartlett, Marian Stewart; Lee, Kang

    2016-10-01

    The current study used computer vision technology to examine the nonverbal facial expressions of children (6-11years old) telling antisocial and prosocial lies. Children in the antisocial lying group completed a temptation resistance paradigm where they were asked not to peek at a gift being wrapped for them. All children peeked at the gift and subsequently lied about their behavior. Children in the prosocial lying group were given an undesirable gift and asked if they liked it. All children lied about liking the gift. Nonverbal behavior was analyzed using the Computer Expression Recognition Toolbox (CERT), which employs the Facial Action Coding System (FACS), to automatically code children's facial expressions while lying. Using CERT, children's facial expressions during antisocial and prosocial lying were accurately and reliably differentiated significantly above chance-level accuracy. The basic expressions of emotion that distinguished antisocial lies from prosocial lies were joy and contempt. Children expressed joy more in prosocial lying than in antisocial lying. Girls showed more joy and less contempt compared with boys when they told prosocial lies. Boys showed more contempt when they told prosocial lies than when they told antisocial lies. The key action units (AUs) that differentiate children's antisocial and prosocial lies are blink/eye closure, lip pucker, and lip raise on the right side. Together, these findings indicate that children's facial expressions differ while telling antisocial versus prosocial lies. The reliability of CERT in detecting such differences in facial expression suggests the viability of using computer vision technology in deception research.

  2. The role of executive functions and theory of mind in children's prosocial lie-telling.

    Science.gov (United States)

    Williams, Shanna; Moore, Kelsey; Crossman, Angela M; Talwar, Victoria

    2016-01-01

    Children's prosocial lying was examined in relation to executive functioning skills and theory of mind development. Prosocial lying was observed using a disappointing gift paradigm. Of the 79 children (ages 6-12 years) who completed the disappointing gift paradigm, 47 (59.5%) told a prosocial lie to a research assistant about liking their prize. In addition, of those children who told prosocial lies, 25 (53.2%) maintained semantic leakage control during follow-up questioning, thereby demonstrating advanced lie-telling skills. When executive functioning was examined, children who told prosocial lies were found to have significantly higher performance on measures of working memory and inhibitory control. In addition, children who lied and maintained semantic leakage control also displayed more advanced theory of mind understanding. Although children's age was not a predictor of lie-telling behavior (i.e., truthful vs. lie-teller), age was a significant predictor of semantic leakage control, with older children being more likely to maintain their lies during follow-up questioning.

  3. Superconductivity discoveries and discoverers : ten physics Nobel laureates tell their story

    CERN Document Server

    Fossheim, Kristian

    2013-01-01

    This book is about the work of 10 great scientists; who they were and are, their personal background and how they achieved their outstanding results and took their prominent place in science history. We follow one of physics and science history's most enigmatic phenomena, superconductivity, through 100 years, from its discovery in 1911 to the present, not as a history book in the usual sense, but through close ups of the leading characters and their role in that story, the Nobel laureates, who were still among us in the years 2001-2004 when the main round of interviews was carried out. Since then two of them already passed away. For each one of the 10 laureates, the author tells their story by direct quotation from interviews in their own words. Each chapter treats one laureate. The author first gives a brief account of the laureates' scientific background and main contribution. Then each laureate tells his own story in his own words. This book is unique in its approach to science history.

  4. SketchStory: telling more engaging stories with data through freeform sketching.

    Science.gov (United States)

    Lee, Bongshin; Kazi, Rubaiat Habib; Smith, Greg

    2013-12-01

    Presenting and communicating insights to an audience-telling a story-is one of the main goals of data exploration. Even though visualization as a storytelling medium has recently begun to gain attention, storytelling is still underexplored in information visualization and little research has been done to help people tell their stories with data. To create a new, more engaging form of storytelling with data, we leverage and extend the narrative storytelling attributes of whiteboard animation with pen and touch interactions. We present SketchStory, a data-enabled digital whiteboard that facilitates the creation of personalized and expressive data charts quickly and easily. SketchStory recognizes a small set of sketch gestures for chart invocation, and automatically completes charts by synthesizing the visuals from the presenter-provided example icon and binding them to the underlying data. Furthermore, SketchStory allows the presenter to move and resize the completed data charts with touch, and filter the underlying data to facilitate interactive exploration. We conducted a controlled experiment for both audiences and presenters to compare SketchStory with a traditional presentation system, Microsoft PowerPoint. Results show that the audience is more engaged by presentations done with SketchStory than PowerPoint. Eighteen out of 24 audience participants preferred SketchStory to PowerPoint. Four out of five presenter participants also favored SketchStory despite the extra effort required for presentation.

  5. Stories and story telling in first-levellanguage learning: a re-evaluation

    Directory of Open Access Journals (Sweden)

    Robert W. Blair

    2013-02-01

    Full Text Available This paper proposes that in the midst of all our theories on language teaching and language learning, we might have overlooked an age-old tool that has always been at the disposal of mankind; the telling of stories. Attention is drawn to how some have found in stories and story telling a driving force of natural language acquisition, a key that can unlock the intuitive faculties ofthe mind. A case is being made out for the re-instalment of stories and associated activities as a means of real, heart-felt functional communication in a foreign language, rather than through a direct assault on the structure of the language itself. Met hierdie artikel word daar voorgestel dat daar opnuut gekyk moet word na 'n hulpmiddel wat so oud is as die mensheid self en wat nog altyd tot ons beskikking was, naamlik stories en die vertel daarvan. Die aandag word daarop gevestig dat daar persone is wat in stories en die verbale oordrag daarvan 'n stukrag ontdek het tot natuurlike taalvaardigheid, 'n sleutel tot die intultiewe breinfunksies. Daar word 'n saak uitgemaak vir die terugkeer na stories en gepaardgaande aktiwiteite as middel tot 'n egte, diep deurleefde en funksionele wyse van kommunikasie in 'n vreemde taal, eerder as 'n direkte aanslag op die taalstruktuur self.

  6. Automated decoding of facial expressions reveals marked differences in children when telling antisocial versus prosocial lies.

    Science.gov (United States)

    Zanette, Sarah; Gao, Xiaoqing; Brunet, Megan; Bartlett, Marian Stewart; Lee, Kang

    2016-10-01

    The current study used computer vision technology to examine the nonverbal facial expressions of children (6-11years old) telling antisocial and prosocial lies. Children in the antisocial lying group completed a temptation resistance paradigm where they were asked not to peek at a gift being wrapped for them. All children peeked at the gift and subsequently lied about their behavior. Children in the prosocial lying group were given an undesirable gift and asked if they liked it. All children lied about liking the gift. Nonverbal behavior was analyzed using the Computer Expression Recognition Toolbox (CERT), which employs the Facial Action Coding System (FACS), to automatically code children's facial expressions while lying. Using CERT, children's facial expressions during antisocial and prosocial lying were accurately and reliably differentiated significantly above chance-level accuracy. The basic expressions of emotion that distinguished antisocial lies from prosocial lies were joy and contempt. Children expressed joy more in prosocial lying than in antisocial lying. Girls showed more joy and less contempt compared with boys when they told prosocial lies. Boys showed more contempt when they told prosocial lies than when they told antisocial lies. The key action units (AUs) that differentiate children's antisocial and prosocial lies are blink/eye closure, lip pucker, and lip raise on the right side. Together, these findings indicate that children's facial expressions differ while telling antisocial versus prosocial lies. The reliability of CERT in detecting such differences in facial expression suggests the viability of using computer vision technology in deception research. PMID:27318957

  7. Recurrent Pregnancy Loss

    Directory of Open Access Journals (Sweden)

    Véronique Piroux

    1997-01-01

    Full Text Available Antiphospholipid antibodies (APA are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.

  8. Chronic unilateral vestibular loss.

    Science.gov (United States)

    Kerber, K A

    2016-01-01

    Chronic unilateral vestibular loss is a condition defined by the presence of reduced function of the peripheral vestibular system on one side, which has generally persisted for 3 or more months. The deficit is demonstrated by a reduction of the vestibular-ocular reflex either at the bedside or on laboratory testing. Though some patients with chronic vestibular loss have disabling symptoms, others are asymptomatic. Causes include a viral/postviral disorder, Menière's disease, structural lesions, ischemia, and trauma. Any other systemic or genetic disorder would be expected to involve both sides at some point. PMID:27638074

  9. "I Tell Them I Know How to Do My ABCs!": Kindergartners' School-Related Conversations with Parents and Associations with Adjustment and Achievement

    Science.gov (United States)

    Patrick, Helen; Johnson, Kiana R.; Mantzicopoulos, Panayota; Gray, DeLeon L.

    2011-01-01

    We examined kindergartners' (N = 160) reports of their conversations with parents about school, including whether parents ask about school, what parents ask about, what children tell them, and whether children want to tell their parents. We also investigated whether school adjustment and achievement were associated with either parent questions or…

  10. Telogen Effluvium Hair Loss

    Science.gov (United States)

    ... for Authors Information for Reviewers Human & Animal Rights Job Postings Sections of the JAOCD JAOCD Archive Published Members Online Dermatology Journals Edit This Favorite Name: Category: Share: Yes No, Keep Private Telogen Effluvium Hair Loss Share | It is normal to lose up to ...

  11. OI Issues: Hearing Loss

    Science.gov (United States)

    ... that focuses on hearing loss and hearing issues. Miracle Ear Children’s Foundation P.O. Box 59261 Minneapolis, MN 55459-0261 (800) 234-5422 www.miracle-ear.com Miracle Ear Children’s Foundation provides free ...

  12. Autism and Hearing Loss.

    Science.gov (United States)

    Rosenhall, Ulf; Nordin, Viviann; Sandstrom, Mikael; Ahlsen, Gunilla; Gillberg, Christopher

    1999-01-01

    Children and adolescents (N=199) with autistic disorder were audiologically evaluated. Mild to moderate hearing loss was diagnosed in 7.9 percent, with deafness diagnosed in 3.5 percent of all cases, which represented a prevalence considerably above that in the general population and comparable to the prevalence found in populations with mental…

  13. Loss and damage

    Science.gov (United States)

    Huq, Saleemul; Roberts, Erin; Fenton, Adrian

    2013-11-01

    Loss and damage is a relative newcomer to the climate change agenda. It has the potential to reinvigorate existing mitigation and adaptation efforts, but this will ultimately require leadership from developed countries and enhanced understanding of several key issues, such as limits to adaptation.

  14. Responding to Amphibian Loss

    NARCIS (Netherlands)

    J.R. Mendelson III; K.R. Lips; R.W. Gagliardo; G.B. Rabb; J.P. Collins; J.E. Diffendorfer; P. Daszak; R. Ibáñez D.; K.C. Zippel; D.P. Lawson; K.M. Wright; S.N. Stuart; C. Gascon; H.R. da Silva; P.A. Burrowes; R.L. Joglar; E. La Marca; S. Lötters; L.H. du Preez; C. Weldon; A. Hyatt; J.V. Rodriguez-Mahecha; S. Hunt; H. Robertson; B. Lock; C.J. Raxworthy; D.R. Frost; R.C. Lacy; R.A. Alford; J.A. Campbell; G. Parra-Olea; F. Bolaños; J.J. Calvo Domingo; T. Halliday; J.B. Murphy; M.H. Wake; L.A. Coloma; S.L. Kuzmin; M.S. Price; K.M. Howell; M. Lau; R. Pethiyagoda; M. Boone; M.J. Lannoo; A.R. Blaustein; A. Dobson; R.A. Griffiths; M.L. Crump; D.B. Wake; E.D. Brodie Jr

    2006-01-01

    In their Policy Forum "Confronting amphibian declines and extinctions" (7 July, p. 48), J. R. Mendelson III and colleagues offer a strategy for "stopping" the widespread losses of frogs, toads, and salamanders. Disease research and captive breeding figure prominently in their call for action.

  15. Heat loss from Buildings

    DEFF Research Database (Denmark)

    Karlsson, Kenneth; Næraa, Rikke

    1997-01-01

    Determination of heat loss coefficients for buildings in Denmark. The coefficient are determined for 15 building groups and 3 year intervals. They are based on the BBR-registre and assumptions of U-values(W/K*m2)and computed in a simple spreed sheet model.The results are used in the REVEILLE...... project for calculations in the SESAM model....

  16. Cascadia's Staggering Losses

    Science.gov (United States)

    Wang, Y.; Vogt, B.

    2001-05-01

    Recent worldwide earthquakes have resulted in staggering losses. The Northridge, California; Kobe, Japan; Loma Prieta, California; Izmit, Turkey; Chi-Chi, Taiwan; and Bhuj, India earthquakes, which range from magnitudes 6.7 to 7.7, have all occurred near populated areas. These earthquakes have resulted in estimated losses between \\3 and \\300 billion, with tens to tens of thousands of fatalities. Subduction zones are capable of producing the largest earthquakes. The 1939 M7.8 Chilean, the 1960 M9.5 Chilean, the 1964 M9.2 Alaskan, the 1970 M7.8 Peruvian, the 1985 M7.9 Mexico City and the 2001 M7.7 Bhuj earthquakes are damaging subduction zone quakes. The Cascadia fault zone poses a tremendous hazard in the Pacific Northwest due to the ground shaking and tsunami inundation hazards combined with the population. To address the Cascadia subduction zone threat, the Oregon Department of Geology and Mineral Industries conducted a preliminary statewide loss study. The 1998 Oregon study incorporated a M8.5 quake, the influence of near surface soil effects and default building, social and economic data available in FEMA's HAZUS97 software. Direct financial losses are projected at over \\$12 billion. Casualties are estimated at about 13,000. Over 5,000 of the casualties are estimated to result in fatalities from hazards relating to tsunamis and unreinforced masonry buildings.

  17. From Loss to Awakening

    Institute of Scientific and Technical Information of China (English)

    高崇毅; 李柳英

    2007-01-01

    Katherine Mansfield's short story A Dill Pickle (1917) shows a full picture of the female image to the readers: Vera's loss in love and her awakening from the sorrow and despair.Vera changes during the talk with her former boyfriend and achieves in awakening as a female at last.

  18. Blood Sugar and Fats

    Science.gov (United States)

    ... hyperglycemia) can be a sign of the disease diabetes mellitus. High blood sugar levels can eventually damage ... treated with the same medications used to treat diabetes. There is no simple blood test for insulin ...

  19. High blood pressure medications

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007484.htm High blood pressure medicines To use the sharing features on this page, please enable JavaScript. Treating high blood pressure will help prevent problems such as heart disease, ...

  20. Hypertension (High Blood Pressure)

    Science.gov (United States)

    ... blood pressure with the development of a practical method to measure it. Physicians began to note associations between hypertension and risk of heart failure, stroke, and kidney failure. Although scientists had yet to prove that lowering blood pressure ...