WorldWideScience

Sample records for blood lipid levels

  1. THE EFFECT OF LIPASE INGESTION UPON BLOOD LIPID LEVELS.

    Science.gov (United States)

    levels. The optical density and hence lipid levels of the blood plasmas were lowered in all subjects when sufficient lipase was ingested . The total...obtain this effect. The blood cholesterol values of normal subjects were not affected, nor was that of a hyperlipemic subject who ingested the lipase

  2. An immune response network associated with blood lipid levels.

    Directory of Open Access Journals (Sweden)

    Michael Inouye

    2010-09-01

    Full Text Available While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies have focused on the underlying pathways of disease pathogenesis. Many loci which are associated with disease and complex phenotypes map to non-coding, regulatory regions of the genome, indicating that modulation of gene transcription plays a key role. Thus, this study generated genome-wide profiles of both genetic and transcriptional variation from the total blood extracts of over 500 randomly-selected, unrelated individuals. Using measurements of blood lipids, key players in the progression of atherosclerosis, three levels of biological information are integrated in order to investigate the interactions between circulating leukocytes and proximal lipid compounds. Pair-wise correlations between gene expression and lipid concentration indicate a prominent role for basophil granulocytes and mast cells, cell types central to powerful allergic and inflammatory responses. Network analysis of gene co-expression showed that the top associations function as part of a single, previously unknown gene module, the Lipid Leukocyte (LL module. This module replicated in T cells from an independent cohort while also displaying potential tissue specificity. Further, genetic variation driving LL module expression included the single nucleotide polymorphism (SNP most strongly associated with serum immunoglobulin E (IgE levels, a key antibody in allergy. Structural Equation Modeling (SEM indicated that LL module is at least partially reactive to blood lipid levels. Taken together, this study uncovers a gene network linking blood lipids and circulating cell types and offers insight into the hypothesis that the inflammatory response plays a prominent role in metabolism and the potential control of atherogenesis.

  3. Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization

    DEFF Research Database (Denmark)

    Vinding, Rebecca K; Stokholm, Jakob; Chawes, Bo Lund Krogsgaard

    2016-01-01

    BACKGROUND: Studies of children's blood lipid profiles in relation to asthma are few, and the results are ambiguous. OBJECTIVE: We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children. METHODS: High...... of increased Feno levels (aβ coefficient, 0.14 log-ppb; 95% CI, -0.02 to 0.30 log-ppb; P = .08). CONCLUSION: The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy...... with assessments of lung function, bronchial responsiveness, fraction of exhaled nitric oxide (Feno), and allergic sensitization. Associations between lipid levels and clinical outcomes were adjusted for sex, passive smoking, and body mass index. RESULTS: High levels of low-density lipoprotein cholesterol were...

  4. Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke

    Institute of Scientific and Technical Information of China (English)

    Lu Hao; Zhenzhen Cheng; Qiang Wu; Shuzhang Li; Liming Chen; Xiaoyong Sai; Zhefeng Liu; Guang Yang; Rongzeng Yan; Lili Wang; Caiyun Fu; Xuan Xu

    2013-01-01

    Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke. However, whether both factors exert a synergistic effect in the onset of stroke remains unclear. The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple inter-vertebral disk protrusion using a paired multivariate logistic regression method. Adjusting for known confounding variables including the patients’ age, gender, smoking status, alcohol consumption status, patient and family medical history, and clinical biochemical indices, elevated homocysteine level was related to the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal ho-mocysteine levels and blood lipids (odds ratio 1.409;95%confidence interval 1.127-1.761). These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids are predis-posed to stroke.

  5. Association between the levels of polyunsaturated fatty acids and blood lipids in healthy individuals

    OpenAIRE

    WANG, SI-PING; Chen, Yan-Hong; Li, Hong

    2012-01-01

    The levels of polyunsaturated fatty acids (PUFAs) in blood is closely associated with the status of the health of individuals; in particular, the lack of ω-3 fatty acids may lead to the development of numerous diseases. The aim of this study was to investigate the levels of PUFAs, and their correlation with triglycerides and other factors in blood. The levels of PUFAs and blood lipids were detected in 156 healthy individuals; the blood samples were tested by combined thin-layer and gas liquid...

  6. Effects of Different Exercise Intensities with Isoenergetic Expenditures on C-Reactive Protein and Blood Lipid Levels

    Science.gov (United States)

    Tsao, Te Hung; Yang, Chang Bin; Hsu, Chin Hsing

    2012-01-01

    We investigated the effects of different exercise intensities on C-reactive protein (CRP), and whether changes in CRP levels correlated with blood lipid levels. Ten men exercised at 25%, 65%, and 85% of their maximum oxygen consumption rates. Participants' blood was analyzed for CRP and blood lipid levels before and after the exercise sessions.…

  7. Effects of Different Exercise Intensities with Isoenergetic Expenditures on C-Reactive Protein and Blood Lipid Levels

    Science.gov (United States)

    Tsao, Te Hung; Yang, Chang Bin; Hsu, Chin Hsing

    2012-01-01

    We investigated the effects of different exercise intensities on C-reactive protein (CRP), and whether changes in CRP levels correlated with blood lipid levels. Ten men exercised at 25%, 65%, and 85% of their maximum oxygen consumption rates. Participants' blood was analyzed for CRP and blood lipid levels before and after the exercise sessions.…

  8. Association between blood lipid levels and personality traits in young Korean women.

    Science.gov (United States)

    Roh, Seung-Ju; Kim, Han-Na; Shim, Unjin; Kim, Bo-Hye; Kim, Su-Jin; Chung, Hye Won; Lee, Hyejin; Sung, Yeon-Ah; Kim, Hyung-Lae

    2014-01-01

    Abnormal lipid levels are important etiological factors associated with the development of atherosclerosis and with increased cardiovascular morbidity and mortality. Lipid levels are also influenced by lifestyle and behavioral factors, which suggests that personality traits might be related to abnormal lipid profiles. Studies on personality traits and lipid levels are relatively scarce in Korea. Therefore, the objective of this study was to examine the association between lipid levels and personality traits in young Korean women. A total of 1,701 young Korean women [mean age  = 24.9±4.6 years (range 17-39)] who volunteered for personality trait evaluation were recruited for this study. Lipid levels, including total cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride, were measured in all subjects after an overnight fast, and a low density lipoprotein (LDL) cholesterol level was calculated. The study population was divided into abnormal and normal lipid level groups according to the clinical criteria. Personality traits were measured using the Revised NEO Personality Inventory for the Five-Factor Model of personality. High neuroticism was associated with low HDL cholesterol levels. Low extraversion and openness were associated with high levels of triglyceride. At the facet level, the association between personality and lipid levels were generally consistent. Angry hostility, self-consciousness, vulnerability to stress, activity, and straightforwardness were associated with HDL cholesterol levels. Activity, positive emotion, aesthetics, actions, and deliberation were associated with triglyceride. When applying clinical criteria, conscientiousness was less likely to have abnormal total cholesterol levels. Our results showed that the women with the low HDL cholesterol levels are like to be more neurotic and the hyperglycemic women are prone to lower extraversion and openness in Korea. Understanding the associations between blood lipid levels

  9. Association between blood lipid levels and personality traits in young Korean women.

    Directory of Open Access Journals (Sweden)

    Seung-Ju Roh

    blood lipid levels and personality traits may have a beneficial effect for the managing of dyslipidemia.

  10. The Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration

    Directory of Open Access Journals (Sweden)

    Yafeng Wang

    2016-10-01

    Full Text Available Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD. However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein cholesterol (HDL-C obtained with an increment of 1 mmol/L could result in a significantly increase in the AMD risk of approximately 18% (relative risk (RR, 1.18; 95% confidence interval (CI, 1.01 to 1.35; I2 = 53.8%; p = 0.007. High levels of total cholesterol (TC, low-density lipoprotein cholesterol (LDL-C, and triglycerides (TG were significantly associated with a decreased risk of AMD (RRs ranging from 0.92 to 0.95; all p < 0.05. The stratified analysis based on AMD subtypes showed that these blood lipids were only significantly associated with the risk of early AMD (all p < 0.05. The association between the blood lipids and AMD risk did not differ substantially based on the other characteristics of the participants. A high HDL-C level was associated with an increased AMD risk, whereas participants with high TC, LDL-C, and TG concentrations may show a decreased risk for this disease. Further well-designed large studies are warranted to confirm the conclusions.

  11. Saturated fat consumption may not be the main cause of increased blood lipid levels.

    Science.gov (United States)

    Dias, C B; Garg, R; Wood, L G; Garg, M L

    2014-02-01

    Consumption of foods rich in saturated fatty acids (SFA) has often been associated with elevated blood lipid levels and consequently with risk for chronic diseases, including coronary heart disease. However, epidemiological and interventional studies on this topic are contradictory. While some studies have established a positive link, other studies have failed to show a significant association between saturated fat consumption and blood lipid levels, and others have even found an inverse association. Moreover, studies using animal models have demonstrated that dietary saturated fats raise blood lipid (cholesterol and triglycerides) levels only when the diet is deficient in omega-3 polyunsaturated fatty acids (n-3PUFA). The n-3PUFA are known for their potential in the management of hyperlipidaemia for the prevention of coronary heart disease, as well as for their anti-arrhythmic, anti-aggregatory and anti-inflammatory potential. We believe that with an adequate consumption of n-3PUFA dietary saturated fat may not result in elevated blood lipid levels. Therefore, we critically evaluated the literature regarding saturated fat and blood lipid level, with an emphasis on the role of n-3PUFA on this relationship. Evidence from animal studies and few clinical trials lead to the hypothesis that there are beneficial or neutral effects of saturated fatty acids when combined with recommended levels of n-3PUFA in the diet. However, an intervention focusing on the background fat when the volunteers' diet is supplemented with n-3PUFA is yet to be done. Proving the authenticity of this hypothesis would mean a substantial change in public health messages regarding saturated fats and their health effects; and also a change in the strategies related to prevention of chronic cardiac and artery diseases.

  12. Blood Lipid Levels, Lipid Lowering Medications, and the Incidence of Atrial Fibrillation: The Atherosclerosis Risk in Communities (ARIC) Study

    Science.gov (United States)

    Lopez, Faye L.; Agarwal, Sunil K.; MacLehose, Richard F.; Soliman, Elsayed Z.; Sharrett, A. Richey; Huxley, Rachel R.; Konety, Suma; Ballantyne, Christie M.; Alonso, Alvaro

    2012-01-01

    Background Several cardiovascular risk factors have been associated with the risk of atrial fibrillation (AF). Limited and inconsistent evidence exists on the association of blood lipid levels and lipid lowering medication use with AF risk. Methods and Results We analyzed 13,969 participants (25% African-American, 45% men) free of AF at baseline from the Atherosclerosis Risk in Communities (ARIC) study. Fasting HDL cholesterol (HDLc), LDL cholesterol (LDLc), triglycerides, and total cholesterol were measured at baseline (1987–89) and each of three follow-up visits. Incidence of AF was ascertained through 2007. The association of the use of statins and other lipid lowering medications with AF was estimated in 13,044 ARIC participants attending visit 2 (1990–92), adjusting for covariates from the previous visit. During a median follow-up of 18.7 years there were 1433 incident AF cases. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) of AF associated with a one standard deviation increase in lipid levels were: HDLc: 0.97 (0.91–1.04); LDLc: 0.90 (0.85–0.96); total cholesterol: 0.89 (0.84–0.95); and triglycerides: 1.00 (0.96–1.04). Participants taking lipid lowering medications had an adjusted HR (95% CI) of AF of 0.96 (0.82–1.13) compared to those not on medications, while those taking statins had an adjusted HR of 0.91 (0.66–1.25) compared to those taking other lipid lowering mediations. Conclusions Higher levels of LDLc and total cholesterol were associated with a lower incidence of AF. HDLc and triglycerides, however, were not independently associated with AF incidence. No association was found between the use of lipid lowering medications and incident AF. PMID:22227953

  13. Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure,lipid profile and blood glucose level

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    To study the relationship of the polymorphism of endothelial nitric oxide synthase(eNOS)gene and blood pressure,lipid profiles and blood glucose level.By using PCR-RFLP,the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure.Taking into account eNOS Glu298Asp polymorphisms,the relationship of blood pressure with triglycerides(TG),total cholesterol(TC),high density lipoprotein(HDL),low density lipoprotein(LDL)and blood glucose level was analyzed.The distribution of eNOS Glu298Asp polymorphism had no significant difference between different blood pressure groups and gender groups,but there was a significant difference between different age groups,diastolic blood pressure groups or BMI groups(P<0.05).Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L(P=0.03,OR=2.65).eNOSGlu298Asp polymorphism and serum lipid could synergistically modulate the blood pressure,eNOS Asp/Asp genotype could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L,eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.

  14. Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM: To evaluate the prognostic value of the combined model for end-stage liver disease (MELD) and blood lipid level in patients with decompensated cirrhosis. METHODS: A total of 198 patients with decompensated cirrhosis were enrolled into the study. The values of triglyceride (TG), cholesterol (TC), high density lipoproteins (HDL) and low density lipoprotein (LDL) of each patient on the fi rst day of admission were retrieved from the medical records, and MELD was calculated. All the patients were followed ...

  15. Relationship between Glycemic Load and Blood Lipid Level in Hospitalized Adult Chinese.

    Directory of Open Access Journals (Sweden)

    Hui Li

    2015-03-01

    Full Text Available Metabolic diseases in China have been on the rise in recent decades, partially due to reduced cereal consumption and excessive intake of low glycemic index (GI foods such as meat and oil. Although the relationship between dietary glycemic load (GL and various metabolic diseases has been extensively studied worldwide, it is unclear whether dietary GL is related to blood lipid levels and dyslipidemia risk in Chinese. The aim of the present study was to investigate the relationship between dietary GL and blood lipid levels and dyslipidemia risk in hospitalized Chinese adults.Dietary GL in 2258 hospitalized Chinese adults was calculated based upon GI, carbohydrate content and daily intake of individual foods. In addition, fasting total cholesterol (TC, triglycerides (TG, HDL cholesterol (HDL-C and LDL cholesterol (LDL-C data were collected. Multiple regression and logistic regression analysis were used to determine the relationship between dietary GL and plasma lipid levels or dyslipidemia risk.Dietary GL remained inversely associated with blood total cholesterol (TC and low-density lipoprotein cholesterol (LDL-C (P0.05.High GL diet, as represented by traditional Chinese dietary pattern, may contribute to reduced risk of dyslipidemia in Chinese adults.

  16. Effect of Folk Dance Training on Blood Oxidative Stress Level, Lipids, and Lipoproteins

    Directory of Open Access Journals (Sweden)

    Okdan Bora

    2016-09-01

    Full Text Available Introduction. Folk dance is a form of physical activity which helps develop the ability to use the whole body in a coordinated way with music, and folk dancers’ characteristics vary according to the particular type of dance practised in a given geographic region. The aims of the study were to evaluate the effects of 12-week folk dance training on blood oxidative stress level, lipids, lipoproteins, as well as muscle damage markers and to define some physical and physiological properties of folk dancers. Material and methods. Thirty-eight healthy male folk dancers aged 21-28 years having an average of 11 years of dance training experience voluntarily participated in the study. All of the physical and physiological measurements and the blood analysis were performed twice, before and after the training period which focused on different regional dances (Caucasus, Bar, Zeybek, Spoon Dance, Thracian dances, and Horon. The training was done 2 hours per day (a total of 10 hours a week, during a 12-week-long period. Results. All the blood parameters were found to be within the specified reference ranges. The training programme had no significant effect on the blood lipid profile, whereas it was found to have positive effects on body fat (p ≤ 0.012, peak oxygen consumption (VO2peak; p = 0.000, muscle damage markers (creatine kinase, Δ% = −19.6, and total antioxidant capacity (p ≤ 0.002. Conclusions. Regular folk dance training was found to have positive effects on body fat, VO2peak, blood total antioxidant capacity, and muscle damage markers. Based on these results, the community should be encouraged to perform folk dance as a recreational physical activity, and public awareness should be raised about the health benefits of practising folk dances.

  17. The relationship between serum lipid levels, high blood pressure and obesity in children

    Directory of Open Access Journals (Sweden)

    Meltem Kurtuncu

    2014-03-01

    Full Text Available Objective: The purpose of this study was to determine serum lipid, cholesterol and obesity levels in healthy children, and then to explore the relationships between these factors. Methods: The sample group consisted of 103 students at Gelik Elementary School in Zonguldak, Turkey who was willing to participate in the study, had not been medically diagnosed with a chronic ailment, and were not taking regular medications. Results: When the students' mean BMI (Body Mass Index measurements were considered, it was found that mean BMI at 13 years of age (21.03 ± 0.23 was higher than at 14 years (20.05 ± 0.20 and that this difference was strongly significant (p=0.002. When the relationships between the students' height, weight, BMI, blood pressure, FBS (Fasting Blood Sugar, cholesterol, LDL (Low Density Lipoprotein, HDL (High Density Lipoprotein measurements were considered, it was seen that there was a positive significant relationship between height-weight (r=0.472; p<0.001, height-blood pressure (r=0.432; p<0.001, and height-FBS (r=0.332; p=0.001. Conclusions: The conclusion drawn was that monitoring blood pressure, cholesterol, LDL and HDL levels in childhood medical examinations is not only important in terms of identifying obesity, but also in identifying nutritional mistakes and deficiencies at an early stage.

  18. Modification of corporal weight, body fat distribution, blood lipids and glucose levels in oral contraceptive users.

    Science.gov (United States)

    Carranza-Lira, S; Bueno Fontal, J P

    2000-01-01

    The association between oral contraceptives and the modification of corporal weight and body fat distribution is controversial. The characteristics of the menstrual cycle, lipids and glucose levels were also analyzed. Thirty women who received ethinylestradiol 0.035 mg and norethindrone 0.400 mg for one year were studied. The following variables were analyzed every 3 months: weight, body mass index (BMI), hip perimeter, waist perimeter, waist-hip ratio (WHR), duration of menstrual cycle, quantity of uterine bleeding, as well as blood levels of cholesterol, triglycerides and glucose. Waist and hip perimeters increased during the third evaluation; as well as the BMI starting from the second evaluation. The triglycerides levels rose from the first evaluation. No modifications were found in the WHR, glucose and cholesterol levels and the duration of the menstrual cycle, but the quantity of uterine bleeding decreased from the third month. The oral contraceptive significantly increased BMI and triglycerides level, but no changes were detected in body fat distribution, cholesterol and glucose levels. Uterine bleeding decreased from the first evaluation.

  19. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

    Science.gov (United States)

    Proitsi, Petroula; Lupton, Michelle K; Velayudhan, Latha; Newhouse, Stephen; Fogh, Isabella; Tsolaki, Magda; Daniilidou, Makrina; Pritchard, Megan; Kloszewska, Iwona; Soininen, Hilkka; Mecocci, Patrizia; Vellas, Bruno; Williams, Julie; Stewart, Robert; Sham, Pak; Lovestone, Simon; Powell, John F

    2014-09-01

    Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. We have used a Mendelian randomization approach to dissect the causal nature of the association between circulating lipid levels and late onset AD (LOAD) and test the hypothesis that genetically raised lipid levels increase the risk of LOAD. We included 3,914 patients with LOAD, 1,675 older individuals without LOAD, and 4,989 individuals from the general population from six genome wide studies drawn from a white population (total n=10,578). We constructed weighted genotype risk scores (GRSs) for four blood lipid phenotypes (high-density lipoprotein cholesterol [HDL-c], low-density lipoprotein cholesterol [LDL-c], triglycerides, and total cholesterol) using well-established SNPs in 157 loci for blood lipids reported by Willer and colleagues (2013). Both full GRSs using all SNPs associated with each trait at ptriglycerides; and OR=0.954, 95% CI 0.76-1.21, p=0.688 per 1 unit increase in total cholesterol). Results for the trait specific scores were similar; however, the trait specific scores explained much smaller phenotypic variance. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels is not associated with elevated LOAD risk. The observed epidemiological associations between abnormal lipid levels and LOAD risk could therefore be attributed to the result of biological pleiotropy or could be secondary to LOAD. Limitations of this study include the small proportion of lipid variance explained by the GRS, biases in case-control ascertainment, and the limitations implicit to Mendelian randomization studies. Future studies should focus on larger LOAD datasets with longitudinal sampled peripheral lipid measures and other markers of

  20. The relation between serum insulin levels and 8-year changes in lipid, lipoprotein, and blood pressure levels.

    Science.gov (United States)

    Mitchell, B D; Haffner, S M; Hazuda, H P; Valdez, R; Stern, M P

    1992-07-01

    Hyperinsulinemia is associated with an adverse pattern of cardiovascular risk factors, including obesity, elevated triglyceride levels, low levels of high-density lipoprotein (HDL) cholesterol, and elevated blood pressure. Whether hyperinsulinemia precedes (and perhaps causes) this deterioration in the risk factors or merely accompanies the deterioration is controversial. We therefore examined the 8-year changes in lipids, lipoproteins, and blood pressure as a function of baseline levels of fasting insulin in 1,383 nondiabetic Mexican-American and non-Hispanic white subjects enrolled between October 1979 and November 1982 in the San Antonio Heart Study, a population-based longitudinal study of cardiovascular risk factors and diabetes in San Antonio, Texas. After age and concomitant changes in body mass index were adjusted for, fasting insulin at baseline was found to be correlated positively with 8-year changes in triglyceride levels and negatively with 8-year changes in HDL cholesterol levels (p less than 0.05). Among the non-Hispanic whites, insulin was more strongly correlated with a decline in HDL cholesterol levels in women than in men (p less than 0.001). Fasting insulin was also positively correlated with changes in both systolic and diastolic blood pressure in non-Hispanic whites, but not in Mexican Americans, although these correlations were slightly diminished and no longer achieved statistical significance after subjects receiving antihypertensive medications were excluded. These results support the hypothesis that in nondiabetic subjects, insulin has a direct regulatory effect on triglyceride and HDL cholesterol levels. These data provide evidence for a possible role for insulin in blood pressure regulation, at least in non-Hispanic whites, although further analysis of this issue is warranted.

  1. High blood cholesterol levels

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000403.htm High blood cholesterol levels To use the sharing features ... stroke, and other problems. The medical term for high blood cholesterol is lipid disorder, hyperlipidemia, or hypercholesterolemia. ...

  2. Correlation bethealtyy ween dietary glycemic index and glycemic load and blood lipid levels in a group of women from Ahvaz

    Directory of Open Access Journals (Sweden)

    Farideh Shishebor

    2011-09-01

    Full Text Available Background & Objectives: There are limited number of studies conducted on the correlation between Glycemic index and Glycemic load of a food program and metabolic factors such as blood lipids in Asian countries including Iran. Therefore, this study aimed at analyzing the correlation between Glycemic index and Glycemic load of Iranian food program and blood lipids. Materials & Methods: The subjects were 95 women working in Ahvaz University of Medical Sciences in the range of 20 to 55 years old. Glycemic index and Glycemic load of the food program was analyzed with 24-hour food recall questionnaires (4-6 recall. For calculating GI and GL, Iranian food GI tables, and also, international GI and GL table were used. The levels of blood lipids including HDL cholesterol, total cholesterol, and triglycerides of the blood were measured and the level of LDL Cholesterol was calculated using Friedewald formula. Also, Anthropometric measurements were done using standard methods. Resulst: The mean age of subjects in this study was 36 years. GI mean was 72.1 and GL mean was 153.2. In this study, there was no significant relation between HDL cholesterol, LDL cholesterol, total cholesterol and Blood TG with Glycemic index and Glycemic load of food program. Conclusion: Unlike findings of west and Asian countries, both dietary GI and GL were not correlated with metabolic factors including blood lipid levels in this study , underreporting of individuals may influence the results of the study.

  3. Low levels of blood lipids are associated with etiology and lethal outcome in acute liver failure.

    Directory of Open Access Journals (Sweden)

    Paul Manka

    Full Text Available Emerging data links different aspects of lipid metabolism to liver regeneration. In patients with acute liver failure (ALF, low levels of lipids may correlate with disease severity. Thus, we determined whether there is an etiology-specific link between lipid levels in patients suffering from ALF and aimed to investigate an effect of lipid levels on the prognosis of ALF.In this retrospective single center study, we reviewed 89 consecutive ALF patients, who met the criteria of the "Acute Liver Failure Study Group". Patient characteristics, clinical data and laboratory parameters were individually analyzed at admission and correlated with the patients' outcome after a four week follow up. Possible endpoints were either discharge, or death or liver transplantation.High-density lipoprotein (HDL, cholesterol and triglyceride levels were significantly lower in patients who died or required a liver transplant. HDL levels were significantly higher in patients with ALF caused by acetaminophen intoxication, compared to fulminant HBV infection or drug induced liver injury. HDL levels correlated with hepatic injury by ALT levels, and Albumin, and inversely correlated with the MELD score, INR, and bilirubin.In our cohort of patients with ALF, we could show that HDL and cholesterol are suppressed. In addition novel etiology specific patterns between acteminophen and non-acteminophen induced liver failure were detected for serum lipid components. Further studies are needed to address the role of cholesterol and lipid metabolism and the according pathways in different etiologies of ALF.

  4. Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To study the influence of soybean fibers on blood sugar, blood_lipid metabolism, and histomorphology in mice models with diabetes mellitus (DM). Method After normal mice and mice with Streptozocin (STZ)_induced DM were fed with forage containing a certain amount of soybean fiber (SF) for 5 weeks, blood sugar and blood lipid were determined, and morphological changes of hepatic and nephritic tissues were observated. Result The results of 5_week experiment had shown: 1. In normal mice fed with SF, the blood sugar level was decreased (P<0.05). There were no obvious changes in serum total cholesterol (TC) and the triglyceride (TG). The high_density_lipoprotein cholesterol (HDL_C) level was increased significantly (P<0.05); 2. Among DM mice, blood sugar was decreased considerably (P<0.001), TC and TG also decreased noticeably (P<0.05), HDL_C increased clearly (P<0.05); 3. SF has a protective role to the liver and kidney of DM mice. Conclusion It is suggested that SF has the function of decreasing blood sugar, blood_lipid and improving their metabolism, and of protecting liver and kidney of DM mice.

  5. Effects of Soybean Fibers on Blood Suga,Lipid Levels and Hepatic_nephritic Histomorphology in Mice With Diabetes Mellitus

    Institute of Scientific and Technical Information of China (English)

    XUHONG; TANSHU-MEI; 等

    2001-01-01

    Objective:To study the influence of soybean fibers on blood sugar,blood-lipid metabolism,and histomorphology in mice odels with diabetes mellitus(D).Method:After normal mice and mice with Streptozocin(STZ)-induced DM were fed with forage containing a certain amount of soybean fiber(SF) for 5 weeks,blood sugar and blood lipid were determined,and morphological changes of hepatic and nephritic tissues were observated.Result The results of 5-week experiment had shown:1.In normal mice fed with SF,the blood sugar level was decreased(P<0.05).There were no bovious changes in serum total cholesterol(TC)and the triglyceride(TG).The highdensity-lipoprotein chloesterol(HDL-C) level was increased significantly(P<0.05);2Among DM mice,blood sugar was decrased considerably(P<0.001),TC and TG also decreased noticeably(P<0.05),HDL-C increased clearly(P<0.05);3\\SF has a protective role to the liver and kidney of DM mice.Conclusion:It is suggested that SF has the function of decreasing blood sugan,blood-lipid and improving their metabolism.and of protecting liver and kidney of DM mice.

  6. Effect of aerobic exercise on blood lipid levels in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Martiem Mawi

    2009-04-01

    Full Text Available High blood total cholesterol (TC, low-density lipoprotein cholesterol (LDL-C and triglycerides (TG, and low concentrations of high-density lipoprotein cholesterol (HDL-C are related to risk for coronary heart disease (CHD development. Growing evidence indicates that physical exercise can prevent at least some of the negative effects on health associated with post. The purpose of this study was to evaluate the effect of regular aerobic exercise for 12 weeks on the levels of total cholesterol (TC, low-density lipoprotein cholesterol (LDL-C, high-density lipoprotein cholesterol (HDL-C, and triglycerides. An experimental study was conducted comprising 62 postmenopausal women, aged 50-70 years, not on hormonal therapy, consuming a regular diet, living in East and South Jakarta, and willing to perform aerobic exercises regularly. The results of this study showed that all four lipid levels differed significantly between the control group and the intervention group, the respective mean levels ± SD for TC being 228.0 ± 39.7 mg/dL vs. 171.6 ± 18.4 mg/dL, (p = 0.000; for LDL-C 149.0 ± 36.9 mg/dL vs. 97.7 ± 17.8 mg/dL, (p = 0.000; for HDL-C 50.9 ± 3.9 mg/dL vs. 71.5 ± 6.7 mg/dL, (p = 0.000; and for triglycerides 150.5 ± 67.5 mg/dL vs. 95.0 ± 37.8 mg/dL (p = 0.000. Thus practitioners recommending exercise for coronary artery disease risk reduction in postmenopausal women.

  7. Study of the Effect of Garlic on Serum Lipids and Blood Glucose Levels in Type 2 Diabetic Patients

    Directory of Open Access Journals (Sweden)

    M Afkhami - Ardekani

    2005-04-01

    Full Text Available Introduction: Hyperlipidemia and diabetes are common risk factors for ischemic heart disease, which is the main cause of mortality in diabetic patients. Strict control of blood glucose and other risk factors in diabetics has led to prevention of complications. Garlic has received particular attention for control of blood glucose and decrease in blood lipid levels. At present, several studies have been carried out in order to prove advantages of garlic. Methods: In this study, effects of garsin (a derivative of garlic present in our country on serum lipids and blood glucose levels in diabetes mellitus type 2 patients was observed. Forty-five type 2 diabetics who had hyperlipidemia were selected. These patients were kept on treatment with 3 tablets of Garsin / day for 4 weeks. Serum lipids and blood glucose levels were measured prior to and at the end of treatment. Results: Relationship between sex and response to treatment in this study was meaningful, such that Gsarsin led to decrease in LDL-C and increase in HDL in females. Conclusion: Therefore, Garsin can be used as an adjunct to treatment in diabetes type 2 patients with hyperlipidemia.

  8. Air pollution and blood lipid markers levels: Estimating short and long-term effects on elderly hypertension inpatients complicated with or without type 2 diabetes.

    Science.gov (United States)

    Xiao, Sanhua; Liu, Ranran; Wei, Youxiu; Feng, Lin; Lv, Xuemin; Tang, Fei

    2016-08-01

    With the development of society and the economy, many Chinese cities are shrouded in pollution haze for much of the year. Scientific studies have identified various adverse effects of air pollutants on human beings. However, the relationships between air pollution and blood lipid levels are still unclear. The objective of this study is to explore the short and long-term effects of air pollution on eight blood lipid markers among elderly hypertension inpatients complicated with or without type 2 diabetes (T2D). Blood lipid markers which met the pre-established inclusion criteria were exported from the medical record system. Air pollution data were acquired from the official environmental protection website. Associations between the air quality index and the blood lipid indexes were analyzed by one-way ANOVA and further Bonferroni correction. In an exposure time of 7 days or longer, blood lipid markers were somewhat affected by poor air quality. However, the results could not predict whether atherosclerosis would be promoted or inhibited by poorer air condition. Changes of blood lipid markers of hypertension inpatients with or without T2D were not completely the same, but no blood lipid markers had an opposite trend between the two populations. The air quality index was associated with changes to blood lipid markers to some extent in a population of hypertension inpatients with or without T2D. Further studies are needed to investigate the potential mechanism by which air pollutants induce blood lipids changes.

  9. Increased hepatic fatty acids uptake and oxidation by LRPPRC-driven oxidative phosphorylation reduces blood lipid levels

    Directory of Open Access Journals (Sweden)

    Ping Zhou

    2016-07-01

    Full Text Available Hyperlipidemia is one of the major risk factors of atherosclerosis and other cardiovascular diseases. This study aimed to investigate the impact of leucine rich pentatricopeptide repeat containing protein (LRPPRC-driven hepatic oxidative phoshorylation on blood lipid levels. The hepatic LRPPRC level was modulated by liver-specific transgenic or adeno-associated virus 8 carried shRNA targeting Lrpprc (aav-shLrpprc. Mice were fed with a high fat diet to induce obesity. Gene expression was analyzed by quantitative real-time PCR and / or western blot. The hepatic ATP level, hepatic and serum lipids contents, and mitochondria oxidative phosphorylation complex activities were measured using specific assay kits. The uptake and oxidation of fatty acid by hepatocytes were assessed using 14C-palmitate. LRPPRC regulated the expression of genes encoded by mitochondrial genome but not those by nuclear genome involved in mitochondria biogenesis, oxidative phosphorylation, and lipid metabolism. Increased oxidative phosphorylation in liver mediated by LRPPRC resulted in the increase of hepatic ATP level. Lrpprc promoted palmitate uptake and oxidation by hypatocytes. The hepatic and serum triglyceride and total cholesterol levels were inversely associated with the hepatic LRPPRC level. These data demonstrated that LRPPRC-driven hepatic oxidative phosphorylation could promote fatty acids uptake and oxidation by hepatocytes and reduce both hepatic and circulating triglyceride and cholesterol levels.

  10. Correlation between blood lipid levels and chronic pancreatitis: a retrospective case-control study of 48 cases.

    Science.gov (United States)

    Ni, Qingqiang; Yun, Lin; Xu, Rui; Shang, Dong

    2014-12-01

    The incidence of chronic pancreatitis (CP) is increasing, and dyslipidemia severely affects the health of middle-aged and elderly people. We investigated the association between blood lipid levels and CP. The serum lipid metabolic indices of 48 patients with CP (CP group) were summarized retrospectively. The physical examination results of 40 randomly selected healthy individuals were used as the normal control (NC) group. Statistical analyses of the blood lipid data were performed between the 2 groups using the case-control study method. High-density lipoprotein-cholesterol (HDL-c) levels decreased and fasting blood glucose (GLU) levels increased in the CP group compared with those in the NC group (P<0.01). Pearson correlation analysis results showed that serum amylase (AMY) was positively correlated with low-density lipoprotein-cholesterol (LDL-c; r=0.414, P<0.05), and urine AMY (UAMY) was positively correlated with total cholesterol (TC; r=0.614, P<0.01) and LDL-c (r=0.678, P<0.01). A binary logistic regression analysis showed that GLU (odds ratio [OR], 5.052; P<0.01) and TC (OR, 1.074; P<0.01) may be risk factors for CP, whereas HDL-c may be a CP protective factor (OR, 0.833; P<0.01). The HDL-c levels decreased and GLU levels increased in the CP group compared with those in the NC group; AMY was positively correlated with LDL-c and UAMY was positively correlated with TC and LDL-c; GLU and TC may be risk factors for CP; and HDL-c may be a CP protective factor. This may be the first time that such results have been reported. These findings will contribute to primary prevention and control of CP progression.

  11. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

    Directory of Open Access Journals (Sweden)

    Petroula Proitsi

    2014-09-01

    Full Text Available Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. We have used a Mendelian randomization approach to dissect the causal nature of the association between circulating lipid levels and late onset AD (LOAD and test the hypothesis that genetically raised lipid levels increase the risk of LOAD.We included 3,914 patients with LOAD, 1,675 older individuals without LOAD, and 4,989 individuals from the general population from six genome wide studies drawn from a white population (total n=10,578. We constructed weighted genotype risk scores (GRSs for four blood lipid phenotypes (high-density lipoprotein cholesterol [HDL-c], low-density lipoprotein cholesterol [LDL-c], triglycerides, and total cholesterol using well-established SNPs in 157 loci for blood lipids reported by Willer and colleagues (2013. Both full GRSs using all SNPs associated with each trait at p<5×10-8 and trait specific scores using SNPs associated exclusively with each trait at p<5 × 10-8 were developed. We used logistic regression to investigate whether the GRSs were associated with LOAD in each study and results were combined together by meta-analysis. We found no association between any of the full GRSs and LOAD (meta-analysis results: odds ratio [OR]=1.005, 95% CI 0.82-1.24, p = 0.962 per 1 unit increase in HDL-c; OR=0.901, 95% CI 0.65-1.25, p=0.530 per 1 unit increase in LDL-c; OR=1.104, 95% CI 0.89-1.37, p=0.362 per 1 unit increase in triglycerides; and OR=0.954, 95% CI 0.76-1.21, p=0.688 per 1 unit increase in total cholesterol. Results for the trait specific scores were similar; however, the trait specific scores explained much smaller phenotypic variance.Genetic predisposition to increased blood cholesterol and

  12. The Effect of Trans-Chalcone on Amylase Activity, Blood Glucose and Lipid Levels in Diabetic and Non Diabetic Rats

    Directory of Open Access Journals (Sweden)

    M Najafian

    2011-04-01

    Full Text Available Introduction & Objective: Alpha amylase is the most important decomposing enzyme in starch. Digestion and absorption of starch in the intestine can be prevented and also the blood sugar levels can be controlled by restrain and control of alpha amylase. The aim of this study was to evaluate the effect of trans-chalcone on amylase activity, blood glucose and lipid levels in diabetic and non diabetic rats. Materials & Methods: This experimental study was conducted in 1388 at Tehran University of Medical Sciences. Sixty rats were randomly divided to ten equal groups: non diabetic control, diabetic control, four non diabetic experiments and four diabetic experiments. Control groups received grape seed oil and experimental groups received 2, 8,16 and 32 mg/kg of body weight in a period of 24 days with a gastric cannula. Blood sugar, every two days, serum insulin levels in days 0,12, and 24 and at the end of the experiment, lipoproteins and alpha amylase activity were measured.The data were analyzed by one way analysis of variance, ANOVA, followed by Turkey,s test with SPSS soft ware . Results: On average Chalcone reduced 25.5% of blood sugar in normal and diabetic rats. IT also decreased the serum insulin level. On average, chalcone decreased 34.9% of alpha amylase activity in normal and diabetic rats. Following disturbances in lipids metabolism caused by diabetes, this drug improved lipoproteins metabolism and reduced water, food and urine volume. Conclusion: This study shows that trans-Chalcone reduces blood sugar and body weight via inhibition of alpha amylas. Moreover, improvement of lipoprotein metabolism may happen via the inhibitory effect of this drug on hydroxyl methyl glutaryl -COA reductase and phosphodiesterase.

  13. Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies

    Science.gov (United States)

    Shah, Sonia; Casas, Juan P.; Gaunt, Tom R.; Cooper, Jackie; Drenos, Fotios; Zabaneh, Delilah; Swerdlow, Daniel I.; Shah, Tina; Sofat, Reecha; Palmen, Jutta; Kumari, Meena; Kivimaki, Mika; Ebrahim, Shah; Smith, George Davey; Lawlor, Debbie A.; Talmud, Philippa J.; Whittaker, John; Day, Ian N.M.; Hingorani, Aroon D.; Humphries, Steve E.

    2013-01-01

    Aims The aim of this study was to quantify the collective effect of common lipid-associated single nucleotide polymorphisms (SNPs) on blood lipid levels, cardiovascular risk, use of lipid-lowering medication, and risk of coronary heart disease (CHD) events. Methods and results Analysis was performed in two prospective cohorts: Whitehall II (WHII; N = 5059) and the British Women’s Heart and Health Study (BWHHS; N = 3414). For each participant, scores were calculated based on the cumulative effect of multiple genetic variants influencing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Compared with the bottom quintile, individuals in the top quintile of the LDL-C genetic score distribution had higher LDL-C {mean difference of 0.85 [95% confidence interval, (CI) = 0.76–0.94] and 0.63 [95% CI = 0.50–0.76] mmol/l in WHII and BWHHS, respectively}. They also tended to have greater odds of having ‘high-risk’ status (Framingham 10-year cardiovascular disease risk >20%) [WHII: odds ratio (OR) = 1.36 (0.93–1.98), BWHHS: OR = 1.49 (1.14–1.94)]; receiving lipid-lowering treatment [WHII: OR = 2.38 (1.57–3.59), BWHHS: OR = 2.24 (1.52–3.29)]; and CHD events [WHII: OR = 1.43 (1.02–2.00), BWHHS: OR = 1.31 (0.99–1.72)]. Similar associations were observed for the TC score in both studies. The TG score was associated with high-risk status and medication use in both studies. Neither HDL nor TG scores were associated with the risk of coronary events. The genetic scores did not improve discrimination over the Framingham risk score. Conclusion At the population level, common SNPs associated with LDL-C and TC contribute to blood lipid variation, cardiovascular risk, use of lipid-lowering medications and coronary events. However, their effects are too small to discriminate future lipid-lowering medication requirements or coronary events. PMID:22977227

  14. Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; The Attica study

    Directory of Open Access Journals (Sweden)

    Zampelas Antonis

    2007-09-01

    Full Text Available Abstract Background We aimed to investigate if overweight and obese adults "close" to Mediterranean diet present better insulin, lipids profile and better pressure levels, compared to individuals close to a more Westernized diet. Methods The ATTICA study is a population-based cohort that has randomly enrolled 3042 adult men and women, stratified by age – gender, from the greater area of Athens, during 2001–2002. Of them, in this work were have studied 1762 participants with excess body weight, meaning overweight (BMI: 25–29.9 kg/m2 and obese (BMI>30 kg/m2. 1064 were men and 698 women (20–89 years old. Adherence to Mediterranean diet was assessed through a diet-score that was based on a validated food-frequency questionnaire. Blood pressure was measured and also fasting glucose, insulin and blood lipids. Insulin sensitivity was also assessed by the homeostasis model assessment (HOMA approach (glucose × insulin/22.5. Results Individuals with excess bodyweight in the highest tertile of diet score, were more insulin sensitive than those in the lowest tertile (11.4% lower HOMA, p = 0.06, had 13% lower levels of total cholesterol (p = 0.001 and 3 mmHg decrease of systolic blood pressure levels (p Conclusion Adherence to Mediterranean diet is modeslty associated with a better insulin sensitivity, lower levels of total cholesterol and lower levels of systolic blood pressure in overweight and obese subjects. This may suggest that compared to general population, the beneficial effect of this diet in cardiovascular system of excess body weight people is limited.

  15. Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients.

    Science.gov (United States)

    Ahangarpour, Akram; Heidari, Hamid; Fatemeh, Ramezani Ali Akbari; Pakmehr, Mostafa; Shahbazian, Hajeye; Ahmadi, Iraj; Mombeini, Zahra; Mehrangiz, Babadi Hajani

    2014-02-04

    Type 2 diabetes is an endocrine disorder that affects a large percentage of patients. High blood glucose causes fatty deposits in the liver which is likely to increase in SGOT and SGPT activities. Significant increase in SGOT/SGPT and low HDL levels is observed in patients with diabetes. Serum fructosamine concentration reflects the degree of blood glucose control in diabetic patients. This study was aimed to investigate the antidiabetic, hypolipidemic and hepatoprotective effects of supplementation of Boswellia serrata in type2 diabetic patients. 60 type 2 diabetic patients from both sexes (30 males and 30 females) were dedicated to the control and intervention groups (30 subjects per group). Boswellia serrata gum resin in amount of 900 mg daily for 6 weeks were orally administered (as three 300 mg doses) in intervention group and the control group did not receive anything. Blood samples were taken at the beginning of the study and after 6 weeks. Blood levels of fructosamine, lipid profiles as well as hepatic enzyme in type 2 diabetic patients were measured. Treatment of diabetic patient with Boswellia serrata was caused to significant increase in blood HDL levels as well as a remarkable decrease in cholesterol, LDL, fructosamine (p < 0.05) SGPT and SGOT levels after 6 weeks (p < 0.01). In spite of reduction of serum triglyceride, VLDL levels in intervention group, we did not detect a significant difference after 6 weeks. This study showed that Boswellia serrata supplementation can be beneficial in controlling blood parameters in patients with type 2 diabetes. Therefore, its use can be useful in patients with medicines.

  16. Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

    Directory of Open Access Journals (Sweden)

    Maram Sushma

    2014-08-01

    Conclusions: Hypothyroid patients demonstrate significant increase in serum lipids as compared to healthy individuals. More females are diagnosed with hypothyroidism and dyslipidemia is associated with primary hypothyroidism. [Int J Res Med Sci 2014; 2(4.000: 1694-1698

  17. Body Mass Index, Blood Lipid and Apolipoprotein levels and Coronary Heart Disease among middle aged Punjabi Khatris of Northwest India

    Directory of Open Access Journals (Sweden)

    Tripta*

    2013-10-01

    Full Text Available Background: Studies have suggested that an elevated plasma concentration of apolipoprotein (apo B coupled with obesity may be considered as an important risk factor for coronary heart disease (CHD than the traditional lipid factors. Coronary artery disease (CAD is a multifactorial disease resulting from interaction among various hereditary, cultural and environment factors. Population specific studies are rare. Aim: The aim of this study was to evaluate the association of body mass index (BMI, blood lipids and apolipoproteins with the CAD among the Khatri caste, which is an indigenous population of Northwest India. Materials and Methods: The study was carried on 150 CAD patients and 150 normal controls belonging to the Punjabi Khatri caste ranging in age from 35-45 years. Height and body weight was measured using standard techniques. Blood was drawn from each subject to analyze serum concentrations of lipids and apolipoproteins. Results: The study demonstrated that CAD patients had elevated BMI in both males and females than normal controls. Apo B levels were an important predictor of CAD. ApoA/ApoB ratio among CAD patients was 0.74 compared with 1.53 in normal subjects; controls had 105.79% higher ApoA/ApoB ratio than CAD subjects. Total cholesterol, LDL-C, triglycerides, LDL-C/HDL-C ratio of the two groups also showed significant differences. Prevalence of obesity in CAD patients was 70.7% compared with 10% in normal controls. Conclusions: Apo B levels were found to the best predictor of CAD, even though significant differences were also found between CAD and normal subjects for other lipoprotein traits. Obesity was high CAD patients than normal controls.

  18. Factors affecting the stability of blood lipid and lipoprotein levels from youth to adulthood: evidence from the Childhood Determinants of Adult Health Study.

    Science.gov (United States)

    Magnussen, Costan G; Thomson, Russell; Cleland, Verity J; Ukoumunne, Obioha C; Dwyer, Terence; Venn, Alison

    2011-01-01

    To examine the effect of lifestyle changes on the stability of blood lipid and lipoprotein levels from youth to adulthood. Prospective cohort study. Australia. Five hundred thirty-nine young adults who underwent measurement at baseline in 1985 when aged 9, 12, or 15 years and again at follow-up between 2004 and 2006. Changes in adiposity, cardiorespiratory fitness, saturated fat intake, smoking, and socioeconomic position. Child and adult blood lipid levels. Using established cut points, we found that substantial proportions of individuals with high-risk blood lipid and lipoprotein levels at baseline no longer had high-risk levels at follow-up. Of the participants who had high-risk levels in youth, those with greater increases in adiposity or who commenced or continued smoking were more likely to maintain high-risk blood lipid and lipoprotein levels (P adulthood affect whether an individual maintains, loses, or develops high-risk blood lipid and lipoprotein levels in adulthood. Interventions that promote weight control in the first instance, but also physical activity, not smoking, and improved socioeconomic position in the transition from youth to adulthood, are likely to be of benefit in preventing adult dyslipidemia.

  19. The effect of lipid regulation with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction

    Directory of Open Access Journals (Sweden)

    Shu XU

    2015-11-01

    Full Text Available Objective To analyze the effect of intensive lipid regulation treatment with atorvastatin on the blood lipid levels and carotid artery plaques in patients with atherosclerotic cerebral infarction.  Methods Ninety-two patients with atherosclerotic cerebral infarction were randomly divided into two groups: observation group (treated by atorvastatin calcium with the dosage of 20 mg/d, N = 46 and control group (treated by diet without lipid-rich food, N=46. Besides, other drugs given to the patients in two groups were the same. The blood lipid levels and the changes of carotid artery plaques in two groups were analyzed and compared before treatment and 3 months after treatment. Results After treatment, the concentrations of total cholesterol [TC, (4.23 ± 0.92 mmol/L vs (5.24 ± 0.68 mmol/L], triglyceride [TG, (2.46 ± 0.28 mmol/L vs (3.33 ± 0.47 mmol/L], low-density lipoprotein cholesterol [LDL-C, (2.52 ± 0.38 mmol/L vs (4.78 ± 0.86 mmol/L] in the patients of observation group were all decreased and significantly lower than those in the control group (P = 0.000, for all, and the concentration of high-density lipoprotein cholesterol [HDL-C, (1.13 ± 0.41 mmol/L vs (0.85 ± 0.32 mmol/L] in the patients of observation group was increased and significantly than that in the control group (P = 0.003. The carotid artery plaque size [(20.25 ± 0.32 mm2 vs (24.42 ± 10.33 mm2] and thickness [(0.59 ± 0.13 mm vs (1.93 ± 0.23 mm] of carotid artery plaques and intima?media thickness [IMT, (1.32 ± 0.67 mm vs (1.63 ± 0.56 mm] of common carotid artery (CCA in the patients of observation group were all significantly lower than those in patients in the control group (P = 0.000, 0.000, 0.010, respectively. Comparing serum alanine aminotransferase (ALT, aspartate aminotransferase (AST, creatine kinase (CK and creatinine (Cr levels after treatment with before treatment, there was no significant difference between 2 groups (P > 0.05, for all.  Conclusions

  20. Effects of Subcutaneous Injection MnO2 Micro- and Nanoparticles on Blood Glucose Level and Lipid Profile in Rat

    Directory of Open Access Journals (Sweden)

    Zahra Mousavi

    2016-11-01

    Full Text Available Background: The use of nanotechnology has led to rapid growth in various areas. Thus, health and safety issues of nanoparticles (NPs should be promptly addressed. Manganese oxide (MnO2 nanoparticles (NPs are typically used for biomedical and industrial applications. However, characterizing the potential human health effects of MnO2 NPs is required before fully exploiting these materials. The aim of this study was to investigate the toxicity of MnO2 micro- and nanoparticles on blood glucose level and lipid profile in male Wistar rats. Methods: A total of 105 rats were divided into one control and two experimental groups. Each experimental group received a single subcutaneous injection of MnO2 micro- and nanoparticles (100 µg/kg, respectively, every two weeks for 14 weeks. Their blood glucose, cholesterol, triglycerides, LDL, and HDL levels were then measured. The data presented as mean±SEM and compared with the repeated measures using the Prism statistical software (version 6.0. Results: Biochemical assessment in plasma samples showed that MnO2 micro- and nanoparticles injection significantly (P<0.01 increased the plasma glucose and cholesterol levels in all and few weeks, respectively. MnO2 nanoparticles significantly (P<0.01 decreased the HDL level in weeks 6, 12, and 14, but MnO2 microparticles decreased the HDL level only in week 12. In both MnO2 micro- and nanoparticles groups, LDL alterations were near to the control group, except for week 10. However, the same treatment had no effect on triglycerides concentrations compared to the control group. Conclusion: Our results show that exposure to nanosized particles at subchronic doses caused adverse changes in animal biochemical profiles, especially in glucose level. It seems that the high oxidative power of these particles is the main reason for these disturbances.

  1. Influence of Atorvastatin/Probucol Combination on Blood Lipid and ...

    African Journals Online (AJOL)

    Lipid and Serum C-Reactive Protein Levels in Patients with. Cerebral Infarction ... analyzed the influence of atorvastatin combined ... Comparison of blood fat level of two groups before and after .... plaque focuses on lipid regulation, oxidation.

  2. Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity.

    Directory of Open Access Journals (Sweden)

    Hui Yang

    Full Text Available Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.

  3. Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity.

    Science.gov (United States)

    Yang, Hui; Huang, Xiaochang; Zeng, Zhijun; Zhang, Wanchang; Liu, Chenlong; Fang, Shaoming; Huang, Lusheng; Chen, Congying

    2015-01-01

    Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS) in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire) populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC) for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.

  4. Effect of Vit C Supplement on Fasting Blood Glucose and Plasma Lipid Level in Type II Diabetic Patients

    Directory of Open Access Journals (Sweden)

    Mehri Delvarianzadeh

    2008-01-01

    Full Text Available Introduction: Diabetic people are more at risk of diseases such as vascular, kidneys and eye diseases, compared with normal people. Since Vit C competitively replaces glucose in most chemical reactions; so inhibit on non enzymatic glycosylation such as hemoglobin and lipoproteins, it seems that Vit C can be effective to prevent diabetic complications .In this study effect of Vit C supplements on blood sugar and fats level in type II diabetic patients was investigated. Methods: This study was conducted as a clinical trial using paired random sampling on 136 type II diabetic patients. At first, the patients weights, age, type of diet were recorded .Then their fasting blood glucose (FBS, glycosylated hemoglobin (HbAIC, Cholesterol, triglyceride, HDL and LDL were measured. After that the patients were divided in two randomized groups. The first group (control was subject of administration of Vit C supplement (1250 mg, 5 times a day, for a period of 3 months and the second group received placebo. Data were analyzed by paired t- test and SPSS Software. Results: In this study most of patients were women (62.2% of control group and 64.7% of placebo group. The mean age between the control group and placebo group were reported 51.2 ± 6.8 and 50.37± 9.71 years respectively. At the end of study , after 3 months of administration of Vit C supplement to control group, the mean concentration of FBS, LDL triglyceride Cholesterol and glycosylated hemoglobin has been reduced significantly with respect to the placebo group and the mean value of HDL has been increased as well. Conclusion: The finding shows that Vit C supplements might reduce the amount of glucose, lipids and glycosylated hemoglobin in patients with type 2 diabetes. Therefore, its consumption in diabetic patients can be recommended and as a result patient complications will be significantly reduced.

  5. The Effects of Different Levels of Dietary Protein and L-Carnitine on Blood Sugar and Lipids of the New GIFT Strain of Juvenile Nile Tilapia (Oreochromis niloticus

    Directory of Open Access Journals (Sweden)

    Gang Chen

    2009-01-01

    Full Text Available The new GIFT (Genetically Improved Farmed Tilapia strain of Nile tilapia is a popular cultivated fish in Asia, but intensive aquaculture using nutritionally imbalanced feed has led to disorder of lipid metabolisms. An 8-week feeding experiment was conducted in order to assess the effects of different levels of L-carnitine (0, 200, 400, 600, and 800 mg/kg and dietary protein (22, 25, and 28% on blood sugar and blood lipid contents of the new juvenile GIFT strain of Nile tilapia. Results showed that dietary protein and L-carnitine had significant influences on glucose (GLU, high-density lipoprotein–cholesterol (HDL-C, total cholesterol (TC, triglyceride (TG, and low-density lipoprotein–cholesterol (LDL-C in the blood serum. The contents of GLU and HDL-C increased with the increases in dietary protein and L-carnitine levels, while the contents of TC, LDL-C, and TG decreased with the increases in dietary protein and L-carnitine levels. The interactive effect of both dietary protein and L-carnitine was most significant on GLU (p = 0.0001, followed by TG (p = 0.001, TC (p = 0.005, HDL-C (p = 0.056, and LDL-C (p = 0.109. These results suggested that high levels of dietary protein and L-carnitine supplementation reduce blood lipids and the burden of the fish liver.

  6. Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

    Science.gov (United States)

    Cano-García, Francisco J.; De Miguel, Manuel; Carrión, Angel M.; Navas, Plácido; Sánchez Alcázar, José A.

    2011-01-01

    Background We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. Methods We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma. Results We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001). A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI). We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI). Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms. However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores). Discussion The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM. PMID:22046409

  7. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans.

    Science.gov (United States)

    Sergeant, Susan; Ruczinski, Ingo; Ivester, Priscilla; Lee, Tammy C; Morgan, Timothy M; Nicklas, Barbara J; Mathias, Rasika A; Chilton, Floyd H

    2016-01-28

    Numerous studies have examined relationships between disease biomarkers (such as blood lipids) and levels of circulating or cellular fatty acids. In such association studies, fatty acids have typically been expressed as the percentage of a particular fatty acid relative to the total fatty acids in a sample. Using two human cohorts, this study examined relationships between blood lipids (TAG, and LDL, HDL or total cholesterol) and circulating fatty acids expressed either as a percentage of total or as concentration in serum. The direction of the correlation between stearic acid, linoleic acid, dihomo-γ-linolenic acid, arachidonic acid and DHA and circulating TAG reversed when fatty acids were expressed as concentrations v. a percentage of total. Similar reversals were observed for these fatty acids when examining their associations with the ratio of total cholesterol:HDL-cholesterol. This reversal pattern was replicated in serum samples from both human cohorts. The correlations between blood lipids and fatty acids expressed as a percentage of total could be mathematically modelled from the concentration data. These data reveal that the different methods of expressing fatty acids lead to dissimilar correlations between blood lipids and certain fatty acids. This study raises important questions about how such reversals in association patterns impact the interpretation of numerous association studies evaluating fatty acids and their relationships with disease biomarkers or risk.

  8. COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China.

    Science.gov (United States)

    Ge, Lin; Wu, Hua-Yu; Pan, Shang-Ling; Huang, Ling; Sun, Peng; Liang, Qing-Hua; Pang, Guo-Fang; Lv, Ze-Ping; Hu, Cai-You; Liu, Cheng-Wu; Zhou, Xiao-Ling; Huang, Ling-Jin; Yin, Rui-Xing; Peng, Jun-Hua

    2015-01-01

    To see the possible relationship between COMT Val158Met polymorphism and blood pressure (BP) and serum lipid levels and its putative role in human longevity, we genotyped COMT Val158Met (rs4680) by PCR-RFLP for members from Bama long-lived families (BLF, n = 1538), Bama non-long-lived families (BNLF, n = 600), Pingguo (a county outside Bama region) long-lived families (PLF, n = 538) and Pingguo non-long-lived families (PNLF, n = 403) after anthropometric measures were collected and serum lipid levels were detected. The distribution of genotypes and alleles among four family groups was significantly different (all P pressure (SBP), pulse pressure (PP), total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) levels of GG genotype carriers were dramatically higher than non-GG carriers in BNLF (P pressure and lipids were observed between genotypes in BLF and PNLF (P > 0.05). Correlation analyses revealed that COMT Val158Met was mainly correlated negatively with SBP, diastolic blood pressure (DBP) and LDL-C in BNLF and negatively with TC level in BLF, BNLF and PLF. These data suggest that COMT Val158Met polymorphism may have more impact on the modulation of BP and lipid profiles in the average families than in the long-lived families in Bama region. The association between this SNP and other phenotypes (e.g. cognition) and its roles in the longevity in Bama area thus warrant further investigation.

  9. Effect of a yoga program on glucose metabolism and blood lipid levels in adolescent girls with polycystic ovary syndrome.

    Science.gov (United States)

    Nidhi, Ram; Padmalatha, Venkatram; Nagarathna, Raghuram; Ram, Amritanshu

    2012-07-01

    To assess the efficacy of yoga therapy on glucose metabolism and blood lipid values in adolescent girls with polycystic ovary syndrome (PCOS). A prospective, randomized, interventional controlled trial recruited 90 adolescents aged between 15 and 18 years who met the Rotterdam criteria for PCOS. A yoga group practiced suryanamaskara, asanas, pranayama, and meditation 1 hour per day each day for 12 weeks while another group practiced conventional physical exercises. The Mann-Whitney U test was used to compare score changes between the 2 groups. The changes in fasting insulin, fasting blood glucose, and homeostasis model assessment of insulin resistance were significantly different in the 2 groups (P0.05). Yoga was found to be more effective than conventional physical exercises in improving glucose, lipid, and insulin values, including insulin resistance values, in adolescent girls with PCOS independent of anthropometric changes. Central Trial Registry of India No.: REFCTRI-2008 000291. Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  10. Perfil lipídico e estado nutricional de adolescentes Blood lipid levels and nutritional status of adolescents

    Directory of Open Access Journals (Sweden)

    Danielle Franklin de Carvalho

    2007-12-01

    Full Text Available OBJETIVOS: Avaliar a associação entre obesidade e dislipidemias em adolescentes do ensino público e privado de Campina Grande-PB, Brasil. MÉTODOS: Estudo transversal com 180 adolescentes de 14 a 17 anos matriculados no ensino público e privado de Campina Grande-PB. O estado nutricional foi classificado segundo os percentis do Índice de Massa Corporal para sexo e idade. Foi realizada coleta sangüínea para avaliação do perfil lipídico (colesterol total, frações HDL-colesterol, LDL-colesterol e triglicerídeos. Considerou-se dislipidemia a existência de alteração em pelo menos um dos exames. As análises estatísticas foram realizadas a partir do Epi Info 3.3 e Stata 7.0. RESULTADOS: A prevalência de sobrepeso foi de 14,4% enquanto que 83,9% dos estudantes eram eutróficos e 1,7% apresentavam baixo peso. Não foram encontradas diferenças estatisticamente significantes para o estado nutricional quando estratificado por sexo e tipo de escola. Todas as taxas bioquímicas investigadas mostraram algum nível de alteração. Chamou à atenção a prevalência de dislipidemia, observada em 66,7% dos estudantes, e a alteração do HDL-colesterol, verificada em 56,7% destes. Registrou-se associação estatisticamente significante (pOBJECTIVE: To evaluate the association between obesity and dyslipidemia in adolescents from public and private schools in Campina Grande, PB, Brazil. METHODS: Cross-sectional study of 180 adolescents, aged between 14 and 17 years, enrolled in the public and private school system of Campina Grande-PB. The nutritional status was classified according to the percentiles of Body Mass Index for gender and age. A blood sample was taken to evaluate the lipid profile (total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride levels. Dyslipidemia was considered when at least one of the blood parameters exceeded reference limits. Statistical analysis was performed with Epi Info 3.3 and Stata 7.0. RESULTS: The

  11. Correlation between thyroid disorders and blood lipid level%甲状腺功能异常与血脂水平的相关性研究

    Institute of Scientific and Technical Information of China (English)

    黄敏; 肖创清

    2015-01-01

    Objective: To investigate the relationship between thyroid dysfunction and blood lipid level. Methods: Two hundred patients with thyroid function problems admitted during April 2013 to March 2015 were enrolled for the study, including 100 cases each with hyperthyroidism or hypothyroidism, and 80 participants undergoing health maintenance examination during the same period served as control. The levels of thyroid hormones and blood lipids in all subjects were measured, and the correlation between their levels was analyzed. Results: By univariate analysis, signiifcant difference was found in all the studied thyroid hormones and blood lipids among the three populations (all P Conclusion: Thyroid dysfunction may cause blood lipid metabolic abnormity, which deserves attention in clinical practice.%目的:探讨甲状腺功能异常与血脂水平的关系。  方法:选择2013年4月—2015年3月收治的甲状腺功能异常患者200例为研究对象,其中甲状腺功能亢进症与甲状腺功能减退症患者各100例,以同期健康体检者80例为对照,检测受试者甲状腺激素与血脂水平,并分析两者相关性。  结果:单因素分析显示,3组间各甲状腺激素与血脂指标差异均有统计学意义(均P  结论:甲状腺功能异可导致血脂代谢的紊乱,临床上应予注意。

  12. Effects of Juniperus oxycedrus ssp. oxycedrus on tissue lipid peroxidation, trace elements (Cu, Zn, Fe) and blood glucose levels in experimental diabetes.

    Science.gov (United States)

    Orhan, Nilüfer; Berkkan, Aysel; Deliorman Orhan, Didem; Aslan, Mustafa; Ergun, Fatma

    2011-01-27

    Juniperus oxycedrus L. (Cupressaceae) fruits and leaves are used internally and pounded fruits are eaten for diabetes in Turkey. To evaluate the interrelationships between the levels of chosen trace elements (copper, iron, and zinc) and hepatic, renal lipid peroxidation (TBARS) in streptozotocin-induced diabetic rats treated with Juniperus oxycedrus ssp. oxycedrus (J.o.s.o.) leaf and fruit extracts for 10 days. J.o.s.o. fruit and leaf extracts were administered in STZ-induced diabetic rats, at doses of 500 and 1000 mg/kg. The blood glucose levels were measured in the 1st, 4th, 7th and 10th day of experiment. Fe, Cu, and Zn contents and lipid peroxidation levels of liver and kidney tissues were determined by atomic absorption spectrophotometry and ultraviolet spectrophotometry, respectively. Treatment of diabetic rats with the J.o.s.o. fruit and leaf extracts decreased the blood glucose levels and both the levels of lipid peroxidation in liver and kidney tissues. J.o.s.o. extracts have augmented Zn concentrations in liver of STZ-induced diabetic rats. Results indicated that J.o.s.o. fruit and leaf extracts might be beneficial for diabetes and its complications. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  13. Fasting and nonfasting lipid levels

    DEFF Research Database (Denmark)

    Langsted, Anne; Freiberg, Jacob J; Nordestgaard, Børge G

    2008-01-01

    Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events.......Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events....

  14. Fasting and nonfasting lipid levels

    DEFF Research Database (Denmark)

    Langsted, Anne; Freiberg, Jacob J; Nordestgaard, Børge G

    2008-01-01

    Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events.......Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events....

  15. Lead levels - blood

    Science.gov (United States)

    Blood lead levels ... A blood sample is needed. Most of the time blood is drawn from a vein located on the inside ... may be used to puncture the skin. The blood collects in a small glass tube called a ...

  16. Modulatory effect of pineapple peel extract on lipid peroxidation, catalase activity and hepatic biomarker levels in blood plasma of alcohol-induced oxidative stressed rats

    Institute of Scientific and Technical Information of China (English)

    Okafor OY; Erukainure OL; Ajiboye JA; Adejobi RO; Owolabi FO; Kosoko SB

    2011-01-01

    Objective: To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation, changes in catalase activities and hepatic biochemical marker levels in blood plasma. Methods: Oxidative stress was induced by oral administration of ethanol (20% w/v) at a dosage of 5 mL/kg bw in rats. After 28 days of treatment, the rats were fasted overnight and sacrificed by cervical dislocation. Blood was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 min. The plasma was analyzed to evaluate malondialdehyde (MDA), catalase activity, aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) concentrations. Results: Administration of alcohol caused a drastic increase (87.74%) in MDA level compared with the control. Pineapple peel extract significantly reduced the MDA level by 60.16% at 2.5 mL/kg bw. Rats fed alcohol only had the highest catalase activity, treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the activity. Increased AST, ALP and ALT activities were observed in rats fed alcohol only respectively, treatment with pineapple peel extract drastically reduced their activities. Conclusions: The positive modulation of lipid peroxidation, catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcohol-induced oxidative stress is an indication of its protective ability in the management of alcohol-induced toxicity.

  17. Does cisplatin-based chemotherapy effect on blood lipid levels of patients with germ cell testicular tumor in long-term follow-up?

    Science.gov (United States)

    Koc, Gokhan; Divrik, Taner Rauf; Unlu, Nuri; Bulut, Volkan; Zorlu, Ferruh

    2011-12-01

    Cisplatin-based chemotherapy is widely used in the treatment for germ cell testicular tumors. However, long-term complications of this treatment have gained importance, and hypercholesterolemia is one of these. In some studies, hypercholesterolemia is reported following the cisplatin-based chemotherapy. In this study, we evaluated the relationship of cisplatin-based chemotherapy and blood lipid levels in long-term survivors of patients with germ cell testicular tumors. A total of 89 testicular cancer patients were evaluated between December 1989 and December 2001. Of these, while 39 received cisplatin-based chemotherapy (Group 1), the remaining control group of 50 testicular cancer patients (Group 2) had no adjuvant treatment. The patients in both groups had at least 5-year follow-up and had no known cardiovascular disease. Fasting lipid profiles were obtained including total cholesterol, triglyceride, low- and high-density lipoprotein and very low-density lipoprotein. These values were compared with the normal range, and the statistical difference between the two groups was evaluated. Student's t test was used for continuous variables, and P chemotherapy in germ cell testicular tumors did not have long-term negative effect on blood lipid levels.

  18. Influence of diet with kale on lipid peroxides and malondialdehyde levels in blood serum of laboratory rats over intoxication with paraquat

    Directory of Open Access Journals (Sweden)

    Elżbieta Sikora

    2013-03-01

    Full Text Available Background. Organism’s lipid peroxidation is one of the most often examined and known physiological process evoked by free radicals. It concerns oxidation reaction of unsaturated fatty acid and/or other lipids leading to lipid oxidation products (LOP, which as a result of further changes generate among others the malondialdehyde molecules. The aim of the work was an estimation if raw or cooked kale addition to rat’s diet infl uences antioxidant defense effi ciency in their organisms in comparison to rats fed with standard AIN-93G diet. Material and methods. The experiment was conducted with 36 Wistar strain, male rats over 21 days. The rats were divided into 3 groups (each 12 stuck which were fed with: standard diet AIN-93G (2 groups, AIN-93G diet with 10% addition of raw kale (2 groups, and AIN-93G with 10% addition of cooked lyophilised kale. The total content of polyphenols (FC method and antioxidant activity (ABTS+• were previously determined in raw and then in cooked kale. On the 20th day of experiment, half of rats (6 stuck of each kind of the diet were injected intraperitoneally by the solution of paraquat (PQ in physiological salt to evoke the oxidative stress. The next day animals were stunned and blood from their hearts was sampled. In the obtained serum, the levels of lipid oxidation products (LOP and malondialdehyde (MDA were assessed. Results. It was observed that in blood serum of rats fed with modifi ed diet with raw and cooked lyophilised kale addition the lipid oxides level was lower in comparison to control group fed with standard diet (p < 0.05. It was found that intoxication with paraquat caused growth of MDA and LOP levels in blood serum of all rats in comparison to not intoxicated groups but that growth was the lowest in group fed diet with cooked kale addition. Conclusion. Diet with kale, both raw and cooked, effi ciently inhibited the lipid peroxidation process in rats’ organisms, ongoing during natural metabolism

  19. Prepregnancy Dietary Patterns Are Associated with Blood Lipid Level Changes During Pregnancy: A Prospective Cohort Study in Rio de Janeiro, Brazil.

    Science.gov (United States)

    Eshriqui, Ilana; Franco-Sena, Ana Beatriz; Farias, Dayana Rodrigues; Freitas-Vilela, Ana Amélia; Cunha, Diana Barbosa; Barros, Erica Guimarães; Emmett, Pauline M; Kac, Gilberto

    2017-07-01

    Physiologic adaptations lead to an increase in blood lipid levels during pregnancy, yet little is known about the influence of prepregnancy dietary patterns. To identify whether prepregnancy dietary patterns that explain the consumption of fiber, energy, and saturated fat are associated with blood lipid levels throughout pregnancy. Prospective cohort study, with data collection at gestational weeks 5 to 13, 20 to 26, and 30 to 36. A food frequency questionnaire was administered at baseline (gestational week 5 to 13). Women with singleton pregnancy (N=299) aged 20 to 40 years, without infectious/chronic disease (except obesity) were enrolled in the study. One hundred ninety-nine women were included in the final analysis. The study took place at a prenatal service of a public health care center in Rio de Janeiro, Brazil, during the period from 2009 to 2012. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and triglyceride levels, measured at all trimesters. Dietary patterns were derived by reduced rank regression. Fiber density, dietary energy density, and percent energy from saturated fat were response variables. Crude and adjusted longitudinal linear mixed-effects regression models were performed to account for confounders and mediators. Interaction terms between dietary pattern and gestational week were tested. Fast Food and Candies; Vegetables and Dairy; and Beans, Bread, and Fat patterns were derived. Our Fast Food and Candies pattern was positively associated with triglyceride level (β=4.961, 95% CI 0.945 to 8.977; P=0.015). In the HDL-C rate of change prediction, significant interactions were observed between both the Fast Food and Candies and Vegetables and Dairy patterns and gestational week (β=-.053, 95% CI -0.101 to -0.004; P=0.035 and β=.055, 95% CI -0.002 to 0.112; P=0.060, respectively). The Beans, Bread, and Fat pattern was not associated with blood lipid levels. Prepregnancy dietary patterns

  20. Lipid peroxides level in the Indonesian elderly

    Directory of Open Access Journals (Sweden)

    Purwantyastuti Purwantyastuti

    2005-06-01

    Full Text Available A cross-sectional study was done to see the possible association of plasma lipid peroxides in the elderly with age and other factors. Plasma lipid peroxides is a product of free radical reactions which according to the latest theory of aging is the cause of aging process. Lipid peroxides were also found high in coronary heart disease. Four hundred forty relatively healthy elderly, age 55-85 years, were randomly chosen from free living elderly under guidance of health care centers (PUSKESMAS in Jakarta. Anamnesis and physical examination were done in the morning in the health centers. Blood samples were taken in fasting conditions, plasma lipids and lipid peroxides were measured according to standard methods. There was an age difference of lipid peroxides level in the elderly, which increased with age up to 70 years old. Elderly 70 years old and over had low plasma lipid peroxides. The level was not related to high plasma lipids. Higher level was found when more chronic degenerative diseases were found. (Med J Indones 2005; 14: 71-7Keywords: lipid peroxides, aging

  1. Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study

    Directory of Open Access Journals (Sweden)

    Fuentes Miguel

    2008-11-01

    Full Text Available Abstract Background There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO E, APOC3 and the peroxisome proliferator-activated receptor-γ-2 (PPARγ2 polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13–18.5 years. Methods A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC and high density lipoprotein cholesterol (HDLc, triglycerides (TG, apolipoprotein (apo A and B, and lipoprotein(a [Lp(a] were measured. Low density lipoprotein cholesterol (LDLc, TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a, TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE ε3ε4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a, yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPARγ2 genotypes. Conclusion The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE ε3/ε4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life.

  2. Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study.

    Science.gov (United States)

    Juhola, Jonna; Magnussen, Costan G; Viikari, Jorma S A; Kähönen, Mika; Hutri-Kähönen, Nina; Jula, Antti; Lehtimäki, Terho; Åkerblom, Hans K; Pietikäinen, Matti; Laitinen, Tomi; Jokinen, Eero; Taittonen, Leena; Raitakari, Olli T; Juonala, Markus

    2011-10-01

    To examine tracking and predictiveness of childhood lipid levels, blood pressure, and body mass index for risk profile in adulthood and the best age to measure the childhood risk factor levels. Study subjects were participants of the longitudinal Cardiovascular Risk in Young Finns Study, started in 1980 (age 3, 6, 9, 12, 15, and 18 years). A total of 2204 subjects participated to the 27-year follow-up in 2007 (age, 30 to 45 years). In both sex groups and in all age groups, childhood risk factors were significantly correlated with levels in adulthood. The correlation coefficients for cholesterol levels and body mass index were 0.43 to 0.56 (P affect associations. The best sensitivity and specificity rates were observed in 12- to 18-year-old subjects. Childhood blood pressure, serum lipid levels, and body mass index correlate strongly with values measured in middle age. These associations seemed to be stronger with increased age at measurements. Copyright © 2011 Mosby, Inc. All rights reserved.

  3. Relation of electrocardiographic left ventricular hypertrophy to blood pressure, body mass index, serum lipids and blood sugar levels in adult Nigerians.

    Science.gov (United States)

    Opadijo, O G; Omotoso, A B O; Akande, A A

    2003-12-01

    Left ventricular hypertrophy (LVH) is considered an independent risk factor even in the absence of systemic hypertension. Electrocardiographic (ECG) LVH with repolarisation changes has been found in some countries to carry more coronary risk than LVH alone. How far this observation is true among adult Nigerians is not known. We therefore decided to study adult Nigerians with ECG-LVH with or without ST-T waves changes and compare them with normal age matched controls (without ECG-LVH) in relation with established modifiable risk factors such as systemic hypertension (BP), body mass index (BMI), fasting blood sugar (FBS) and serum lipids such as total cholesterol (Tc), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG). Adult Nigerians who were consecutively referred to the ECG laboratory were randomly recruited. Three hundred patients were studied. Their blood pressures (BP) as well as body mass indices were recorded after recording their resting 12 read ECG using portable Seward 9953 ECG machine. Their waist-hip ratio (WHR) was also recorded. Blood samples were taken to determine their fasting blood sugar and serum lipids. Their ECG tracings were read by the cardiologists involved in the study while the blood samples were analysed by the chemical pathologist also involved in the study. At the end of the ECG reading, the patients were divided into 3 groups according to whether there was no ECG-LVH (control group A), ECG-LVH alone (group B), and ECG-LVH with ST-T waves changes (group C). One hundred and fifty (50%) patients belonged to group A, 100 (33.3%) patients to group B and 50 (16.7%) group C. Group B patients were found to have higher modifiable risk factors in form of systemic BP. Tc, LDL-C, and WHR compared to group A. However, the group C patients had increased load of these coronary risk factors in terms of BP elevation, higher BMI, FBS, and scrum cholesterol compared to group B. In addition

  4. Laboratory Aspects of Blood Lipids

    Science.gov (United States)

    Townsend, F. M.

    1970-01-01

    Classification of blood hyperlipemias by electrophoresis or ultracentrifugation according to density fraction is described and therapeutic measures for humans with hyperlipoproteinemia are outlined. The statistically significant relationship between high serum cholesterol levels and incidence of coronary disease prescribes restricted caloric intake or physical exercise to burn excess calories as preventive measures.

  5. HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats

    Science.gov (United States)

    Głuch-Lutwin, Monika; Knutelska, Joanna; Jakubczyk, Magdalena; Waszkielewicz, Anna; Kotańska, Magdalena

    2016-01-01

    Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of dual 5-HT1A and 5-HT7 antagonists with α1-adrenolitic properties i.e. 1-[(2,6-dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-15). Here, we evaluated the influence of chronic administration of HBK-14 and HBK-15 on blood pressure (non-invasive blood pressure measurement system for rodents), lipid profile (total cholesterol, low density lipoproteins—LDL, high density lipoproteins—HDL, triglycerides), glucose level, and liver enzymes activity (aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase). We determined potential antihistaminic (isolated guinea pig ileum) and antioxidant properties (ferric reducing ability of plasma–FRAP, non-protein thiols–NPSH, stable free radical diphenylpicrylhydrazyl—DPPH) cytotoxicity. Our experiments revealed that HBK-14 and HBK-15 did not influence blood pressure, lipid profile, glucose level or liver enzymes activity in rats after 2-week treatment. We also showed that none of the compounds possessed antioxidant or cytotoxic properties at antidepressant- and anxiolytic-like doses. HBK-14 and HBK-15 very weakly blocked H1 receptors in guinea pig ileum. Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders. PMID:27788267

  6. Modulatory effect of pineapple peel extract on lipid peroxidation,catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats

    Institute of Scientific and Technical Information of China (English)

    Okafor; OY; Erukainure; OL; Ajiboye; JA; Adejobi; RO; Owolabi; FO; Kosoko; SB

    2011-01-01

    Objective:To investigate the ability of the methanolic extract of pineapple peel to modulate alcohol-induced lipid peroxidation,changes in catalase activities and hepatic biochemical marker levels in blood plasma.Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 niL/kg bw in rats.After 28 days of treatment,the rats were fasted overnight and sacrificed by cervical dislocation.Blood was collected with a 2 mL syringe by cardiac puncture and was centrifuged at 3000 rpm for 10 min.The plasma was analyzed to evaluate malondialdehyde(MDA),catalase activity,aspartate aminotransferase(AST),alkaline phosphatase(ALP) and alanine aminotransferase(ALT) concentrations.Results:Administration of alcohol caused a drastic increase(87.74%) in MDA level compared with the control.Pineapple peel extract significantly reduced the MDA level by 60.16%at 2.S mL/kg bw.Rats fed alcohol only had the highest catalase activity,treatment with pineapple peel extract at 2.5 mL/kg bw however, reduced the activity.Increased AST,ALP and ALT activities were observed in rats fed alcohol only respectively,treatment with pineapple peel extract drastically reduced their activities. Conclusions:The positive modulation of lipid peroxidation,catalase activities as well as hepatic biomarker levels of blood plasma by the methanolic extract of pineapple peels under alcoholinduced oxidative stress is an indication of its protective ability in the management of alcoholinduced toxicity.

  7. Variations in erythrocyte antioxidant levels and lipid peroxidation status and in serum lipid profile parameters in relation to blood haemoglobin A1c values in individuals with type 2 diabetes mellitus.

    Science.gov (United States)

    Annadurai, Thangaraj; Vasanthakumar, Azhagarsamy; Geraldine, Pitchairaj; Thomas, Philip A

    2014-07-01

    The present study aimed to evaluate the antioxidant and lipid peroxidation status in erythrocytes and serum lipid profile parameters, in relation to haemoglobin A1c (HbA1c) concentrations, in patients with type 2 diabetes mellitus and in normal healthy individuals. Sixty test individuals with diabetes and 15 control individuals were categorized as: Group I, control (non-diabetes); Group II, individuals with diabetes with HbA1c levels ≤7.0% (53 mmol/mol); Group III, individuals with diabetes with HbA1c levels between 7.1 and 8.0% (54 and 64 mmol/mol); Group IV, individuals with diabetes with HbA1c levels between 8.1 and 9.0% (65 and 75 mmol/mol); Group V, individuals with diabetes with HbA1c levels >9.0% (75 mmol/mol). Blood samples were collected to measure: blood glucose and HbA1c levels; haemolysate levels of enzymatic antioxidants and non-enzymatic antioxidants and malondialdehyde (MDA); and serum total cholesterol, triglyceride and high-density lipoprotein (HDL)-cholesterol levels. Correlations between blood HbA1c values and all parameters were sought. Significantly lower mean activities/levels of antioxidant parameters and significantly higher mean levels of MDA were noted in haemolysate samples from patients with diabetes than in those from control individuals. Significantly higher mean serum concentrations of total cholesterol and triglycerides and significantly lower mean concentrations of HDL-cholesterol were noted in patients with diabetes than in control individuals. Further, moderate to strong correlations were observed between values of antioxidants, MDA and lipid profile parameters and blood concentrations of HbA1c. These results suggest that HbA1c values may be potentially useful not only to indicate long-term glycemic control to indicate onset of complications at a clinically detectable level and molecular level. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  8. Age- and Gender-Specific Reference Intervals for Fasting Blood Glucose and Lipid Levels in School Children Measured With Abbott Architect c8000 Chemistry Analyzer.

    Science.gov (United States)

    Tamimi, Waleed; Albanyan, Esam; Altwaijri, Yasmin; Tamim, Hani; Alhussein, Fahad

    2012-04-01

    Reference intervals for pubertal characteristics are influenced by genetic, geographic, dietary and socioeconomic factors. Therefore, the aim of this study was to establish age-specific reference intervals of glucose and lipid levels among local school children. This was cross-sectional study, conducted among Saudi school children. Fasting blood samples were collected from 2149 children, 1138 (53%) boys and 1011 (47%) girls, aged 6 to 18 years old. Samples were analyzed on the Architect c8000 Chemistry System (Abbott Diagnostics, USA) for glucose, cholesterol, triglycerides, HDL and LDL. Reference intervals were established by nonparametric methods between the 2.5th and 97.5th percentiles. Significant differences were observed between boys and girls for cholesterol and triglycerides levels in all age groups (P < 0.02). Only at age 6-7 years and at adolescents, HDL and LDL levels were found to be significant (P < 0.001). No significant differences were seen in glucose levels except at age 12 to 13 years. Saudi children have comparable serum cholesterol levels than their Western counterparts. This may reflect changing dietary habits and increasing affluence in Saudi Arabia. Increased lipid screening is anticipated, and these reference intervals will aid in the early assessment of cardiovascular and diabetes risk in Saudi pediatric populations.

  9. [Serum lipids and blood pressure levels in the +Mapuche population living in the Chilean region of Araucanía].

    Science.gov (United States)

    Stockins, B; Larenas, G; Charles, M; Standen, D; Espinoza, O; Illesca, M; Opazo, J A; Carrasco, B; Lanas, F; Davis, M

    1998-11-01

    Chilean aboriginal populations (Mapuche) predominantly live in the region of Araucanía, in the southern part of the country. Their cardiovascular risk factors have not been systematically assessed. To study the prevalence of cardiovascular risk factors in the Mapuche population. Blood pressure, weight, height, dietary habits, fasting serum total cholesterol, HDL cholesterol and triglycerides were measured in 1.948 adults living in 28 Mapuche communities. Thirteen percent of males and 16% of females had high blood pressure. Body mass index was 25.5 kg/m2 in males and 28.1 kg/m2 in females. Forty five percent of women and 24% of men were classified as obese. Mean serum total cholesterol was 186.7 +/- 9.6 mg/dl, HDL cholesterol was 58.7 +/- 30.7 mg/dl, total cholesterol/HDL cholesterol was 3.4 +/- 2 and triglycerides were 155.2 +/- 91.2 mg/dl. Twenty eight percent of males and 9.6% of females smoked. Mapuche individuals have higher levels of HDL cholesterol a better total cholesterol/HDL cholesterol ratio and lower frequency of smoking than non aboriginal Chileans subjects.

  10. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: decreased CIMT, reduced plasma lipid levels, and decreased blood pressure

    Directory of Open Access Journals (Sweden)

    Yacov Fogelman

    2016-04-01

    Full Text Available Background: Ethanolic extract of licorice root has been shown to reduce low-density lipoprotein (LDL oxidation in atherosclerotic mice and in both hypercholesterolemic and normal lipidemic humans. Objective: This study examined the effect of licorice-root extract on carotid intima-media thickness (CIMT in individuals with hypercholesterolemia. Design: Individuals with hypercholesterolemia (total cholesterol ≥6.18 mmol/L [240 mg/dL] and without significant stenosis were randomly allocated to two groups: an experimental group that consumed 0.2 g/day of ethanolic extract of licorice root for 12 months, and a control group that received a placebo. Results: Of 110 eligible participants, 94 (41–80 years old completed the study. A significant CIMT decrease from 0.92±0.25 mm to 0.84±0.21 mm was observed in the experimental group compared with an increase from 0.85±0.17 mm to 0.88±0.19 mm in the control group. Mean plasma total cholesterol levels and LDL cholesterol decreased, at the range baseline to 1 year, from 284±32 mg/dl to 262±25 mg/dl and from 183±8.5 mg/dl to 174±9.1 mg/dl, respectively, for the experimental group (p<0.001 and from 291±35 to 289±31 mg/dl and from 177.6±10.7 to 179.3±9.6 (p=0.08, respectively, for the control group. Mean high-density lipoprotein (HDL did not change significantly in either group. In the experimental group, systolic blood pressure decreased from 138±12 mmHg to 125±13 mmHg after 1 year (p=0.01 and increased from 136±15 mmHg to 137±13 mmHg in the control group. Diastolic blood pressure decreased from 92±9 mmHg to 84±10 mmHg (p=0.01 in the experimental group and increased from 89±11 mmHg to 90±8 mmHg in the control group. Conclusion: Following 1 year of licorice consumption, mean CIMT, total cholesterol, LDL levels, and blood pressure were decreased. This suggests that licorice may attenuate the development of atherosclerosis and of related cardiovascular diseases.

  11. A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs.

    Science.gov (United States)

    Val-Laillet, David; Besson, Marie; Guérin, Sylvie; Coquery, Nicolas; Randuineau, Gwénaëlle; Kanzari, Ameni; Quesnel, Hélène; Bonhomme, Nathalie; Bolhuis, J Elizabeth; Kemp, Bas; Blat, Sophie; Le Huërou-Luron, Isabelle; Clouard, Caroline

    2017-02-06

    A suboptimal early nutritional environment (i.e., excess of energy, sugar, and fat intake) can increase susceptibility to diseases and neurocognitive disorders. The purpose of this study was to investigate in nonobese Yucatan minipigs (Sus scrofa) the impact of maternal diet [standard (SD) vs. Western (WD) diet] during gestation and 25 d of lactation on milk composition, blood metabolism, and microbiota activity of sows (n = 17) and their piglets (n = 65), and on spatial cognition (n = 51), hippocampal plasticity (n = 17), and food preferences/motivation (n = 51) in the progeny. Milk dry matter and lipid content, as well as plasma total cholesterol and free fatty acid (FFA) concentrations (P < 0.05) were higher in WD than in SD sows. Microbiota activity decreased in both WD sows and 100-d-old piglets (P < 0.05 or P < 0.10, depending on short-chain FAs [SCFAs]). At weaning [postnatal day (PND) 25], WD piglets had increased blood triglyceride and FFA levels (P < 0.01). Both SD and WD piglets consumed more of a known SD than an unknown high-fat/-sucrose (HFS) diet (P < 0.0001), but were quicker to obtain HFS rewards compared with SD rewards (P < 0.01). WD piglets had higher working memory (P = 0.015) and reference memory (P < 0.001) scores, which may reflect better cognitive abilities in the task context and a higher motivation for the food rewards. WD piglets had a smaller hippocampal granular cell layer (P = 0.03) and decreased neurogenesis (P < 0.005), but increased cell proliferation (P < 0.001). A maternal WD during gestation and lactation, even in the absence of obesity, has significant consequences for piglets' blood lipid levels, microbiota activity, gut-brain axis, and neurocognitive abilities after weaning.-Val-Laillet, D., Besson, M., Guérin, S., Coquery, N., Randuineau, G., Kanzari, A., Quesnel, H., Bonhomme, N., Bolhuis, J. E., Kemp, B., Blat, S., Le Huërou-Luron, I., Clouard, C. A maternal Western diet during gestation and lactation modifies offspring

  12. [Expression of nuclear hormone receptors PPAR, LXR and RXR in the liver and lipid and glucose levels in blood in susceptible and resistant to hepatocarcinogenesis mice strains].

    Science.gov (United States)

    Pivovarova, E N; Baginskaia, N V; Perepechaeva, M L; Il'nitskaia, S I; Dushkin, M I

    2010-01-01

    Earlier it was shown that male mice of the DD/He strain were highly susceptible to ortho-aminoasotoluene (OAT) induced hepatocarcinogenesis, and resistant to spontaneous liver tumor development as compared to the CC57BR/Mv strain. In the present work we have made a comparative investigation of peroxisome proliferator-activated receptor (PPAR), liver X-receptor (LXR) and retinoic X-receptor (RXR) mRNA levels in liver as well as concentrations of corticosterone, glucose, lipids and insulin in blood of male DD/He and CC57BR/Mv mice. Using the multiplex RT-PCR method it was found that PPAR-alpha, PPAR-gamma, RXR-alpha and RXR-beta mRNA content was essentially decreased in the liver of DD mice as compared to mice of the CC57BR strain. No significant interstrain differences of LXR-alpha and LXR-beta mRNA content were found. In DD micetere was more then the 3-fold decrease of blood content of corticosterone, which is involved in PPAR and RXR regulation. DD mice demonstrated a significant decrease in blood serum glucose and insulin concentrations as well as higher reactivity to insulin as compared with CC57BR mice. Elevated blood total cholesterol and cholesterol HDL level were found in DD mice whereas triglyceride content was basically the same in both mouse strains. It is known that glucocorticoids, PPAR and RXR play crucial role in transcription regulation of inflammation response. Therefore our data allow to suggest that decreased corticosterone level in blood, PPAR and RXR mRNA content in liver of the DD strain may lead to induction of inflammation by OAT exposure, resulting in a high incidence of tumorigenesis in this strain.

  13. 脑卒中患者血脂水平及调脂治疗的临床疗效%Blood lipid levels in patients with stroke and clinical efficacy of lipid-regulating therapy

    Institute of Scientific and Technical Information of China (English)

    王少辉

    2012-01-01

    目的 通过分析脑卒中患者的血脂水平,并比较其调脂治疗的临床疗效,探讨血脂对脑卒中发生及预后的影响.方法 纳入缺血性脑卒中患者90例、脑出血患者90例,并选择同期在我院住院的非脑卒中患者120例为对照组,应用日立7060全自动生化仪检测甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白( HDL-C)和低密度脂蛋白(LDL-C)水平.将脑出血及脑梗死患者随机随机分为调脂治疗组及非调脂治疗组,治疗前、后按照Fugl-Meyer运动功能评分(FMA)、美国国立卫生研究院卒中量表(NIHSS)和日常生活能力(ADL)分级评定疗效.结果 脑卒中(出血和梗死)患者的TG、TC、LDL-C水平明显高于对照组,而HDL-C低于对照组,脑出血组TC、LDL-C低于脑梗死组.2个月后,调脂治疗组FAM评分、NIHSS评分和ADL分级评定优于非调脂治疗组.结论 高TG、TC、LDL-C及低HDL-C水平是脑卒中的危险因素,适当调脂治疗能改善脑卒中患者的预后.%Objective To explore the impacts of blood lipid on the occurrence and prognosis of stroke by analyzing lipid levels in patients with different types of stroke and comparing the clinical efficacy of lipid-regulating therapy.Methods Levels of triglyceride ( TG ),total cholesterol ( TC ),high-density lipoprotein cholesterol ( HDL-C ),and low-density lipoprotein cholesterol( LDL-C )were measured by a Hitachi 7060 automatic biochemical analyzer in 90 patients with cerebral infarction,90 patients with cerebral hemorrhage,and 120 control subjects without stroke.The stroke patients were randomly assigned to receive lipid-regulating therapy ( lipid-regulating group ),or no lipid-regulating therapy ( non-lipid-regulating group ).The efficacy was compared using the Fugl-Meyer motor assessment ( FMA ),National Institute of Health Stroke Scale ( NIHSS ),and Activities of Daily Living( ADLs )Scale between the two groups before and after treatment.Results Levels of TC,TG and LDL-C were

  14. GDM患者血同型半胱氨酸水平及其与血脂相关性研究%Relationship between blood homocysteine level and blood lipids of the patients with gestational diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    熊俊; 唐卉; 王素梅; 苏莎; 黄玲玲; 钟琳琳; 曾雅畅

    2013-01-01

    Objective: To study the blood homocysteine ( HCY) level of the patients with gestational diabetes mellitus ( GDM ) and the correlation between HYC and blood lipids.Methods: 40 GDM patients who received prenatal examination and deliveried in the hospital from December 2011 to October 2012 were selected into GDM group, and 40 normal pregnant women were selected into control group at the same time.The level of blood lipids, HCY, fasting plasma glucose (FPG) , cretinine and so on in the two groups were recorded in detail.Detected blood lipids included serum total cholesterol (TC) , triglyceride (TG) , high density lipoprotein - cholesterol ( HDL - C) and low density lipoprotein - cholesterol ( LDL - C) .The level of blood HCY in the two groups was compared and the correlations between HCY and related indexes (including blood lipids, FPG and the cretinine) were analyzed.Results: The level of blood HCY in GDM group was significantly higher than that of control group ( P 0.05 ) .Compared with control group, the levels of TG, LDL - C, FPG in GDM group were increased significantly (P < 0.05) .Spearman analysis indicated that there was a positive correlation between blood HCY and serum LDL - C level (P < 0.05 ) .Conclusion: Patients with GDM have blood HCY metabolism disturbance, which indicates that monitoring the level of blood HCY is good for observing the state of illness of patients with GDM, and intervening the level of serum LDL - C may reduce the level of HCY and relieve the injuries of vessels.%[摘 要] 目的:研究妊娠期糖尿病(gestational diabetes mellitus,GDM)妇女血浆同型半胱氨酸(homocysteine,HCY)水平及其与血脂的相关性.方法:选择2011年12月~2012年10月在该院检查并分娩的GDM患者40例(GDM组),并以同期40例正常妊娠孕妇(正常组)为对照,详细记录两组分娩前血HCY、血脂[血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、空腹血糖

  15. Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome.

    Science.gov (United States)

    Kojadinovic, Milica I; Arsic, Aleksandra C; Debeljak-Martacic, Jasmina D; Konic-Ristic, Aleksandra I; Kardum, Nevena Dj; Popovic, Tamara B; Glibetic, Marija D

    2017-04-01

    Pomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group. A statistically significant decrease in the relative amount of arachidonic acid (P juice significantly increased the relative amount of total mono-unsaturated fatty acids (P juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  16. Primary care of patients with high cardiovascular risk : Blood pressure, lipid and diabetic target levels and their achievement in Hungary.

    Science.gov (United States)

    Szigethy, Endre; Jancsó, Zoltán; Móczár, Csaba; Ilyés, István; Kovács, Eszter; Róbert Kolozsvári, László; Rurik, Imre

    2013-07-01

    Cardiovascular diseases are responsible for the majority of premature deaths in Hungary as well. Most of them could be prevented with healthy lifestyle of patients and adequate drug prescription of primary care physicians. Earlier European surveys found wide differences between the practices and achievements of different countries in this field. The study was based on and designed according to the framework of previous European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) studies and aimed presenting Hungarian results and comparing with the achievements of other countries and previous Hungarian surveys. Among rural and urban settings, 679 patients under continuous care (236 diabetics, 218 with dyslipidaemia, and 225 with hypertension) were consecutively selected by 20 experienced general practitioners. The mean age of patients was 60.3 years (men) and 64.0 years (women). Among diabetics, less than 7 % of glycated hemoglobin (HbA1c) values were found in 42.5 % patients, while only 11.4 % patients had fasting plasma sugar less than 6.0 mmol/L. Of the patients treated for dyslipidaemia, the target level of triglyceride was reached by 40.6 %, recommended total cholesterol by 14.2 % and the HDL-cholesterol by 71.8 %. The therapeutic control of total and HDL-cholesterol was better in men, although women had better triglyceride values. The achievement among patients with hypertension was 42.0 %. Significantly higher blood pressure was measured by patients who were treated with not recommended combinations of antihypertensive medication. A remarkable improvement could be observed in Hungary in the field of secondary prevention. It was greater among patients with hypertension and dyslipidaemia and smaller in diabetes care. Compared to the results of published European surveys, Hungary occupies a good position, but further improvement is still required.

  17. Chlorophytum borivilianum root extract maintains near normal blood glucose, insulin and lipid profile levels and prevents oxidative stress in the pancreas of streptozotocin-induced adult male diabetic rats.

    Science.gov (United States)

    Giribabu, Nelli; Kumar, Kilari Eswar; Rekha, Somesula Swapna; Muniandy, Sekaran; Salleh, Naguib

    2014-01-01

    The effect of C. borivilianum root on blood glucose, glycated hemoglobin (HbAIc), insulin and lipid profile levels in diabetes mellitus are not fully understood. This study therefore investigated the effect of C. borivilianum root on the above parameters and oxidative stress of the pancreas in diabetes. C. borivilianum root aqueous extract (250 and 500 mg/kg/day) was administered to streptozotocin (STZ)-induced male diabetic rats for 28 days. Body weight, blood glucose, HbA1c, insulin, lipid profile levels and glucose homeostasis indices were determined. Histopathological changes and oxidative stress parameters i.e. lipid peroxidation (LPO) and antioxidant enzymes activity levels of the pancreas were investigated. C. borivilianum root extract treatment to diabetic rats maintained near normal body weight, blood glucose, HbA1c, lipid profile and insulin levels with higher HOMA-β cell functioning index, number of Islets/pancreas, number of β-cells/Islets however with lower HOMA-insulin resistance (IR) index as compared to non-treated diabetic rats. Negative correlations between serum insulin and blood glucose, HbA1c, triglyceride (TG) and total cholesterol (TC) levels were observed. C. borivilianum root extract administration prevented the increase in lipid peroxidation and the decrease in activity levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) with mild histopathological changes in the pancreas of diabetic rats. C. borivilianum root maintains near normal levels of these metabolites and prevented oxidative stress-induced damage to the pancreas in diabetes.

  18. Blood pressure relationship to nitric oxide, lipid peroxidation, renal function, and renal blood flow in rats exposed to low lead levels.

    Science.gov (United States)

    Dursun, Nurcan; Arifoglu, Canan; Süer, Cem; Keskinol, Leyla

    2005-05-01

    The results of experiments designed to show that inhibition of nitric oxide production in rats exposed to low lead levels increases vascular resistance, decreases renal blood flow and glomerular function, and enhances oxidative stress. Forty-five adult male Sprague-Dawley rats were divided into four groups. Group A was used as controls and consisted of rats that received no treatment; group B acted as NO-inhibited controls by receiving L-NAME (N(G)-nitro-l-arginine methyl ester) as the NO inhibitor; group C was injected intraperitoneally with 8 mg/kg lead acetate for 2 wk; and group D receiving lead acetate plus L-NAME. Compared to healthy controls, significant elevation of the mean (pbpu) in the controls, 488+/-220 bpu in the L-NAME controls, 1050+/-458 bpu in the lead-treated group, and 878+/-487 bpu in the Pb plus L-NAME group. Low-level lead exposure did not change the urinary flow rate, creatinine clearance, and the creatinine, potassium, phosphorus, glucose, and protein excretion in 24-h urine. In the lead plus NO-inhibited rats, a significant decrease in sodium ion excretion was observed (p<0.01). The NO levels of the lead exposed, L-NAME-treated controls, and L-NAME plus lead-exposed groups are significantly lower compared to untreated controls: p<0.002, p<0.001, and p<0.01, respectively. When compared to untreated controls, the plasma malondialdehyde levels were not significantly different in the lead exposed, lead plus L-NAME, and L-NAME control groups. These results suggest that lead-induced hypertension might be related to a decrease of NO and consequent vasoconstriction, rather than to a decrease of renal blood flow or to decreases in renal sodium.

  19. Blood lipids and prostate cancer

    DEFF Research Database (Denmark)

    Bull, Caroline J; Bonilla, Carolina; Holly, Jeff M P

    2016-01-01

    Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL...... into logistic regression models to estimate the presence (and direction) of any causal effect of each lipid trait on prostate cancer risk. There was weak evidence for an association between the LDL genetic score and cancer grade: the odds ratio (OR) per genetically instrumented standard deviation (SD) in LDL......, comparing high- (≥7 Gleason score) versus low-grade (cancers was 1.50 (95% CI: 0.92, 2.46; P = 0.11). A genetically instrumented SD increase in TGs was weakly associated with stage: the OR for advanced versus localized cancer per unit increase in genetic risk score was 1.68 (95% CI: 0...

  20. Effects of diet containing monosodium glutamate on organ weights, acute blood steroidal sex hor mone levels, lipid profile and er ythrocyte antioxidant enzymes activities of rats

    Directory of Open Access Journals (Sweden)

    Chiedozie Onyejiaka Ibegbulem

    2016-09-01

    Full Text Available Objective: To study the effects of diet containing monosodium glutamate on visceral organ weights, acute blood steroidal sex hormone levels, serum lipid profile (SLP and erythrocyte antioxidant enzymes activities of Wistar rats. Methods: The Wistar rats were grouped into two groups of six rats each. The ones in Group 1 (control group were placed on water and pelletized standard guinea feed ad libitum, whereas Group 2 was regarded as test group [Wistar rats (WR-monosodium glutamate (MSG group] and the Wistar rats received water, compounded diet of MSG and pelletized standard guinea feed ad libitum. After 33 days of feeding study, rat body weight was obtained. Rats were sacrificed and the incisions were made into the thoracic cavity and blood samples were drawn by cardiac puncture as a terminal event. Plasma was assayed for estradiol and testosterone concentrations, SLP and erythrocyte peroxidase and catalase activities. Visceral organ weights were also measured. Results: WR-MSG exhibited marginal alterations in blood estradiol and testosterone concentrations. Elevation of serum triacylglycerol concentration in WR-MSG was corresponded to 77.7%. Increases in serum concentrations of very low-density lipoprotein cholesterol and low-density lipoprotein cholesterol in WR-MSG were corresponded to 70.6% and 41.0% respectively. Erythrocyte peroxidase and catalase activities showed marginal alterations. Alterations in visceral organs-to-body weights ratios were not profound. Conclusions: Blood testosterone and estradiol concentrations were not significantly (P > 0.05 altered, which may not be connected with the low dose of MSG in the diet. Marginal alterations of SLP did not indicate atherogenicity in WR-MSG. The visceral organs were not atrophic or hypertrophic because of the comparatively low dose of MSG consumed by WR-MSG and the duration of the feeding experiment.

  1. Effects of Urtica dioica supplementation on blood lipids, hepatic enzymes and nitric oxide levels in type 2 diabetic patients: A double blind, randomized clinical trial

    Science.gov (United States)

    Amiri Behzadi, Alidad; Kalalian-Moghaddam, Hamid; Ahmadi, Amir Hossein

    2016-01-01

    Objective: Oxidative stress plays an important role in the development of diabetic complications including metabolic abnormality-induced diabetic micro-vascular and macro-vascular complications. Urtica dioica L. (U. dioica) has been traditionally used in Iranian medicine as an herbal remedy for hypoglycemic or due to its anti-inflammatory properties. The aim of the present study was to evaluate the effects of hydro-alcoholic extract of U. dioica on blood lipids, hepatic enzymes and nitric oxide levels in patients with type 2 diabetes mellitus. Materials and Methods: 50 women with type 2 diabetes participated in this study and were randomly divided into two groups namely, control and intervention groups. Control group received placebo and intervention group received hydro-alcoholic extract of U. dioica. Before and after 8 weeks of continuous treatment, some biochemical serum levels including FPG, TG, SGPT, SGOT, HDL, LDL, SOD and NO were measured. Results: The results indicated that after 8 weeks, in the intervention group, FPG, TG, and SGPT levels significantly decreased and HDL, NO and SOD levels significantly increased as compared to the control group. Conclusion: Our results encourage the use of hydro-alcoholic extract of U. dioica as an antioxidant agent for additional therapy of diabetes as hydro-alcoholic extract of U. dioica may decrease risk factors of cardiovascular incidence and other complications in patients with diabetes mellitus. PMID:28078249

  2. Effect of eicosapentaenoic Acid (EPA) and vitamin e on the blood levels of inflammatory markers, antioxidant enzymes, and lipid peroxidation in Iranian basketball players.

    Science.gov (United States)

    Ghiasvand, R; Djalali, M; Djazayery, Sa; Keshavarz, Sa; Hosseini, M; Askari, Gh; Jani, N; Fardad, N; Fatehi, F

    2010-01-01

    Exercise can change the release of numerous cytokines and modulate their receptor systems. Dietary ω-3 lipids may decrease the levels of inflammatory cytokines and prostaglandins (PGs). Therefore, in this study, we investigated the effects of exercise and eicosapentaenoic acid (EPA) supplementation, with or without vitamin E, on the blood levels of IL-2, TNF-α, catalase, glutathione reductase, and MDA in male basketball players. Thirty-four well-trained male basketball players were enrolled into the study. Venous blood samples were obtained from all subjects between 5:00 and 6:00 p.m., after intensive endurance exercising for 2 hours, at the baseline and after intervention. Subjects received 2g EPA and/or 400 IU vitamin E or placebo depends on their groups for 6 weeks. There were significant fall (paired t-test) in TNF-α in group1(P< 0.05), and in MDA in group 3 (P<0.05), whereas there were significant increase in glutathione reductase in groups1 and 3 (P< 0.05), and in MDA in group2 (P< 0.05).There were significant differences (Tukey) in glutathione reductase between groups 2 and 3 (P< 0.05), and in IL-2 between groups 1 and other groups (P< 0.01), but there were no significant differences in MDA, CAT, and TNF-α, among groups after 6 week of intervention. Six weeks of EPA+vitamin E supplementation enhances the plasma levels of IL-2 and erythrocytes glutathione reductase, whereas it reduces TNF-α, and 6 weeks of EPA supplementation alone enhances only the serum level of MDA.

  3. Effect of corn replacement with graded levels of wheat screening and enzyme supplementation on performance, blood lipids, viscosity and jejunal histomorphology of finisher broilers

    Energy Technology Data Exchange (ETDEWEB)

    Mazhari, M.; Golian, A.; Kermanshahi, H.

    2015-07-01

    An experiment was carried out to study the effect of corn replacement with five levels of wheat screening (0, 150, 300, 450 and 600 g/kg of diet) with (0.5 g/kg of diet) or without xylanase-glucanase enzyme on performance, blood lipids, viscosity and jejunal histomorphology of finisher broilers (25-42 days of age). Five hundred day-old Ross-308 male broiler chicks were fed by a standard commercial diet up to 24 days of age, then randomly assigned to 10 diets. Each diet was fed to five groups of ten chicks each. There was not significant differences in body weight gain (BWG), feed intake, and feed conversion ratio of birds fed with different levels of wheat screening (WS), whereas enzyme increased (p<0.05) BWG. Different levels of WS and enzyme did not have a significant effect on relative weights of carcass, breast, thigh, and abdominal fat of broilers. Relative weights of gizzard, pancreas, small and large intestine, and relative length of jejunum and jejunal and ileal viscosity were increased (p<0.05) by WS, while were decreased (p<0.05) by enzyme. The serum cholesterol level decreased (p<0.05) by increasing levels of WS. Jejunal histomorphological observations showed (p<0.05) shorter and thicker villus and lower crypt depth by increasing levels of WS, while addition of enzyme to the diets, affected (p<0.05) reversely to these parameters. The results showed that the addition of wheat screening up to an inclusion level of 600 g/kg of diet had no adverse effect on broiler performance in the finisher (25-42 d) phases whereas decreased serum cholesterol levels, increased viscosity and villus atrophy. The dietary administration of exogenous enzyme improved performance parameters and decreased viscosity and villus atrophy of broiler jejunum. (Author)

  4. Effect of Fatless Tenebrio Molitor Linneeus Powder on Blood Glucose and Blood Lipid Level of Mice%黄粉虫脱脂粉对小鼠血糖和血脂水平的影响

    Institute of Scientific and Technical Information of China (English)

    李汉臣; 赵希艳; 吉志新; 杨晓宽; 缴宝丰

    2013-01-01

      为研究黄粉虫脱脂粉对糖尿病小鼠血糖水平和高脂饮食小鼠血脂水平的影响,以ICR小鼠为实验动物,分别给糖尿病模型和高脂饮食小鼠饲料中添加20%、10%、5%剂量黄粉虫脱脂粉,另设对照组;分别于喂养第10天和第20天测定其空腹血糖水平,喂养结束后测定其空腹血脂水平。结果表明:黄粉虫脱脂粉不能降低糖尿病小鼠血糖值;而5%剂量黄粉虫脱脂粉即可有效预防高脂饮食小鼠血中胆固醇和甘油三酯含量的升高。%To explore the effects of fatless Tenebrio molitor Linneeus powder on blood glucose level in diabetic mice and blood lipid level in mice fed by high fat diet, fatless Tenebrio molitor Linneeus powder of 20%, 10%and 5%dose was mixed into the feed of ICR mice which had been diabetes model or were fed on high fat diet. The mice in another group were treated differently as control. Then the blood glucose level on empty stomach of the mice was determined in the 10th day and the 20th day and the blood lipid level on empty stomach in the end of the trail. Results:The funtion of Tenebrio molitor Linneeus powder to dropping blood glucose level of diabetic mice could not appear. But 5%dose of Tenebrio molitor Linneeus powder could restrain evidently the rising of TC and TG content in blood of the mice.

  5. [Relationship between occupational stress and blood glucose, blood lipid, blood pressure of video display terminal operators].

    Science.gov (United States)

    Zhang, Xing; Song, Hui; Chen, Nan; Liu, He-rong; Zhu, Ling-qin; Zhang, Zhen-xiang; Wang, Ling

    2007-03-01

    To explore the relationship between occupational stress and blood glucose, Blood lipid and blood pressure. 108 video display terminals(VDT) operators who had the working experience were recruited to the study. The occupational stress indicator (OSI), the lever of blood glucose, cholesterol, triglyceride, lipoprotein of high density and lipoprotein of low density in serum were measured by using GOD-PAP, CHOD-PAP, GPO-PAP and PVS. The subjects were classified into three groups according to the score of occupational stress. The contents of blood glucose of low, middle and high level of stress groups were (3.39 +/- 1.24), (3.59 +/- 1.26), (2.54 +/- 0.94) mmol/L respectively (F = 7.324, P stress, the content of blood glucose decreased significantly (r = -0.376, P occupational stress, among video display terminals and it can be used as the index for estimating occupational stress.

  6. Effect of Tenebrio Molitor Linneeus Oil on Blood Lipid Level of Mice%黄粉虫油对小鼠血脂水平的影响

    Institute of Scientific and Technical Information of China (English)

    李汉臣; 吉志新; 赵希艳; 杨晓宽

    2012-01-01

    Varied dose Tenebrio Molitor Linneeus oil was mixed into the feed of mice to explore the functions of preventing or treating hyperlipidemia, compared with normal control which fed on normal feed and model control which fed on high fat feed. The results showed that Tenebrio Molitor Linneeus oil could evidently prevent hyperlipidemia when mice were fed 30 d,which substituted for 30% ,70% and 100% pig oil in high fat feed or be added extra 3% ,and could maintain blood lipid of mice on normal level. When mice were fed 20 d continuously again on feed in which cholesterol content was maintain the same as former high fat feed in the mean time pig oil was removed and 3% ,7% and 10% Tenebrio Molitor Linneeus oil was mixed. After mice were turned into hyperlipidemia through fed on high fat feed 30d, serum TG level of mice was apparently dropped but serum TC level and the ratio of HDL - C and LDL - C were not varied obviously. And the function of Tenebrio Molitor Linneeus oil was the same as deep sea fish oil. Conclusion ; Tenebrio Molitor Linneeus oil can prevent high blood TG level of mice as well as prevent blood TC level of mice fed on high fat feed increasing,but cannot decrease the blood TC level of hyperlipidemia mice.%以小鼠为试验动物,喂饲基础饲料为正常对照,高脂饲料为模型对照,分别研究不同剂量黄粉虫油掺入其饲料中对高脂血症的预防和治疗作用.结果表明:将高脂饲料中的猪油分别以黄粉虫油替换30%、70%、100%或额外增加3%的虫油喂养30 d,能显著预防其血TG和TC水平的升高,且维持在正常水平;给小鼠喂饲高脂饲料30 d造成其高TG、高TC模型后,维持饲料胆固醇水平不变去掉猪油后,添加3%、7%和10%比例的黄粉虫油和在其高脂饲料基础上另外添加3%的黄粉虫油再喂养20 d,均能显著降低其血清TG含量,但不能降低其血清TC含量及改善其HDL -C和LDL -C比例;且发现黄粉虫油与深海鱼油的作用

  7. Mendelian randomisation study of the associations of vitamin B12 and folate genetic risk scores with blood pressure and fasting serum lipid levels in three Danish population-based studies

    DEFF Research Database (Denmark)

    Husemoen, L L N; Skaaby, T; Thuesen, B H

    2016-01-01

    BACKGROUND/OBJECTIVES: The aim was to examine the association of genetic risk scores (GRSs) of vitamin B12 and folate-associated variants with blood pressure and lipids. SUBJECTS/METHODS: The study included 12 532 adults from three population-based studies (Inter99, Health2006 and Dan-MONICA10.......017), but not with blood pressure, triglyceride, and low-density lipoprotein and total cholesterol levels. CONCLUSIONS: GRSs were not associated with blood pressure and lipid levels, except for an association between the GRS for folate and HDL cholesterol. Further studies are needed to determine whether a causal...... and folate, respectively. The β coefficients (95% confidence interval (CI), P-value) for regression of log-transformed serum B12/folate on the weighted GRSs were 0.57 (0.54, 0.61), Pblood pressure...

  8. 不同年龄脑梗死与血脂水平的相关性研究%Correlation research between the patients with cerebral infarction in different ages and blood lipid levels

    Institute of Scientific and Technical Information of China (English)

    蒋波; 郭纯; 谭利明; 吴军; 肖志杰; 廖坚

    2003-01-01

    AIM: To investigate the relationship between the patients with cerebral infarction(CI) in different ages and blood lipid levels.METHODS:The serum concentration of blood lipid levels were measured in 211 patients with CI and 144 control cases.RESULTS: The level of lipoprotein(a)[Lp(a)] in the young adults with CI and the levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL C), apolipoproteinB100(ApoB100) and Lp(a) in the subgroup of mid adults with CI were much higher than corresponding controls. The levels of TC, LDL C ApoB100 and Lp(a) in the subgroup of olds were significantly higher when compared with the corresponding controls, while the high density lipoprotein cholesterol(HDL C) level was lower. Multiple linear regression showed that age had positive correlation to TC and ApoB100 and negative correlation to HDL C. CONCLUSION: There are different disturbances of blood lipid metabolism in the patients with CI in different ages.The serum Lp(a) levels may be an independent risk factor for CI.

  9. Endogenous Estradiol and Testosterone may Predispose toward Atherogenic Lipid Profile, but Higher Blood Level of Testosterone is Associated with Lower Number of Stenoses in the Coronary Arteries of Men with Coronary Disease

    Science.gov (United States)

    Wranicz, Jerzy Krzysztof; Cygankiewicz, Iwona; Kula, Piotr; Walczak-Jedrzejowska, Renata; Slowikowska-Hilczer, Jolanta; Kula, Krzysztof

    2006-01-01

    Objectives: To assess the correlations between blood levels of sex steroid hormones and blood lipid profile or the degree of coronary artery stenosis in men with coronary artery disease (CAD). Methods: 111 men with stable CAD, aged 36-73 yrs, unselected for the coexisting clinical coronary risk factors were prospectively studied. Degree of coronary stenosis was assessed angiographically using different indices. Total cholesterol (T-Ch), high density lipoproteins cholesterol (HDL-Ch), low density lipoproteins cholesterol (LDL-Ch), triglicerydes (TG), testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), and sex hormone binding globulin (SHBG) were measured in the blood. Free testosterone index (FTI) was calculated. Results: A positive, significant correlations were found between blood concentrations of estradiol and T-Ch (r=0.29, p<0.01) or LDL-Ch (r=0.34, p<0.005) as well as between FTI and blood LDL-Ch (r=0.23, p<0.05). Blood level of estradiol negatively correlated with HDL-Ch/T-Ch ratio (r=-0.21, p<0.05). While blood levels of T-Ch correlated positively with 3 out of 5 applied here indices of coronary stenosis, blood LDL-Ch with two of them. In turn, blood level of testosterone negatively correlated with one index of coronary stenosis (r=-0.26, p<0.05). Conclusion: In men with CAD, plasma estradiol concentrations are predictive for T-Ch, LDL-Ch and HDL-Ch/TCh ratio, and FTI for LDL-Ch. Regression analyses indicated that while sex steroid hormones may predispose toward atherogenic lipid profile and are predictive for the number and degree of coronary artery stenosis, higher blood level of total testosterone was associated with the lower number of stenosis in the coronary arteries. Hence, endogenous testosterone may have beneficial effect on coronary arteries. PMID:23674975

  10. Effects of hawthorn, Semen cassiae and compatibility on blood lipid levels%山楂、决明子及其配伍的降血脂作用

    Institute of Scientific and Technical Information of China (English)

    綦振峰; 李官浩; 郑昌吉; 梁成云; 孙美玲; 杨震; 金海莉

    2013-01-01

    To study the effects of hawthorn, Semen cassiae and compatibility of hawthorn and Semen cassiae in sausage on organ coefficient and blood lipid levels of mice, fed mouse with basic feed and basic feed added with 30% ordinary sausage, sausage containing 3% hawthorn crude extract, 2% Semen cassiae crude extract, compatibility of 3% hawthorn and 2% Semen cassiae crude extract, respectively. The results showed that the sausage which was added cassia, hawthorn and their combination were all significantly reduced mice kidney index (P< 0.05), reduce the liver index (P<0.01), reduce low density lipoprotein cholestein(LDL-C) content (P<0.01), and increase high density lipoprotein cholestein (HDL-L) content(P<0.01); the sausage which was added Hawthorn can significantly reduce total cholesterol (TC) content, added combination can significantly reduce triglyceride (TG) content. But the sausage which was added hawthorn, cassia seed and its compatibility had no significant (P>0.05) effects on mice cardiac index, spleen index and abdominal fat weight. So the addition of hawthorn, cassia seed and their combination in sausage can reduce fat deposition in the liver and kidney, lower the level of blood lipid and the combination in sausage had the excellent effect.%为研究山楂、决明子及其配伍加入香肠中对小鼠脏器指数和血脂水平的影响,以小鼠为研究对象,饲喂基础饲料及分别添加了30%的普通香肠、山楂香肠(3%山楂粗提液)、决明子香肠(2%决明子粗提液)、配伍香肠(3%山楂粗提液+2%决明子粗提液)的饲料.结果表明:香肠中添加山楂、决明子及其配伍均能显著(P<0.05)降低小鼠的肾脏指数,极显著(P<0.01)降低小鼠的肝脏指数;极显著(P<0.01)降低低密度脂蛋白胆固醇(LDL-C)含量,极显著(P<0.01)升高高密度脂蛋白胆固醇(HDL-C)含量;香肠中添加山楂能显著(P<0.05)降低总胆固醇(TC)的含量,香肠

  11. Blood cadmium concentration and lipid profile in Korean adults

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kisok, E-mail: kimkisok@kmu.ac.kr [Department of Public Health, Keimyung University, 1000 Shindang-dong, Daegu 704-701 (Korea, Republic of)

    2012-01-15

    Although animal experiments have shown that cadmium exposure induces alterations in lipid profiles, no epidemiological study of this relationship has been performed. The objective of this study was to evaluate the association between blood cadmium concentration and blood lipid levels in Korean adults. A cross-sectional study comprising participants (n=3903) aged 20 years or older from the 2005, 2008, and 2009 Korea National Health and Nutrition Examination Surveys was conducted. Demographic characteristics and dietary intake were obtained from the participants by questionnaire, and cadmium and lipid levels were determined by analysis of blood samples. After adjusting for demographic and dietary factors, blood concentration of cadmium was positively associated with the risk of low high-density lipoprotein cholesterol (HDL-C) in a dose-dependent manner (p for trend <0.001). In addition, the odds ratios (ORs) of a high triglyceride to HDL-C ratio was significantly increased in the high blood cadmium groups [OR=1.36; 95% confidence interval (CI), 1.03-1.79 for fourth quintile and OR=1.41; 95% CI, 1.07-1.86 for fifth quintile] compared with the lowest quintile group. However, high blood cadmium was not associated with a risk of high total cholesterol, high low-density lipoprotein cholesterol, or high triglycerides. These data suggest that an increased cadmium body burden increases the risk of dyslipidemia, mainly due to the increased risk of low HDL-C and the high ratio of triglycerides to HDL-C.

  12. Analysis of total bile acid and blood lipid levels in patients with obstructive jaundice%阻塞性黄疸患者总胆汁酸与血脂水平分析

    Institute of Scientific and Technical Information of China (English)

    吕红; 胡汉宁; 程小欢

    2015-01-01

    Objective To investigate the changes of total bile acid (TBA) and blood lipid level in patients with obstructive jaundice, and to analyze the correlation between TBA and blood lipid level. Methods One hundred and four patients with obstructive jaundice from August 2012 to December 2013 in our hospital were selected as case group, which were then divided into low level group and high level group according to the level of total bile acids. Eighty healthy individuals in the same period in the Outpatient Department were selected as control group. The level of blood lipid and TBA were compared between the three groups. Results Total cholesterol (TC), triglyceride (TG), TBA, total bilirubin (T-Bil) and direct bilirubin (D-Bil) in the case group were all significantly higher than those in the control group (P0, P0,P<0.05),与LDL-C、HDL-C、apo A1、Lp(α)呈显著负相关(r<0,P<0.05)。结论阻塞性黄疸患者伴有程度不同的脂代谢紊乱,总胆汁酸可能起着重要促进作用。

  13. 经介入治疗女性冠心病患者术前血脂水平分析及与Syntax评分的关系%Analysis for the blood lipid levels in female patients with coronary heart disease before percutaneous coronary intervention and the relationship between the blood lipid levels and Syntax score

    Institute of Scientific and Technical Information of China (English)

    王永军; 周旭晨; 黄榕翀; 张妍; 佘在霞; 赵军魁; 石勇; 马爱蕊

    2011-01-01

    目的 探讨行冠状介入治疗的女性冠心病患者术前血脂水平与冠状动脉Syntax评分的关系,为临床调脂治疗提供理论依据.方法 回顾性调查行介入治疗女性冠心病患者246例.病例分为急性ST段抬高心肌梗死(STEMI)组56例和非ST段抬高心肌梗死(non-STEMI)组190例.根据syntax评分分为冠脉病变轻、中、重度3组,分别调查各组的术前血脂水平.结果 STEMI组较non-STEMI组:年龄偏大(P<0.05)、脑血管病史较多(P<0.05);Apo-A1和TG水平差异有统计学意义(P<0.05).STEMI 组各血脂成分在Syntax评分轻中重3组间差异无统计学意义(P>0.05).non-STEMI组:LP(a)水平Syntax评分轻度病变组低于中度病变组(P<0.05);Apo-B/Apo-A1轻度病变组低于重度病变组(P<0.05);余各项血脂水平在3组间差异无统计学意义.结论 LP(a)和Apo-B/Apo-A1是女性冠心病(non-STEMI)患者较重要的血脂指标.%Objective To evaluate the relationships between blood lipids levels and Syntax score in female patients with coronary heart disease ( CHD) before percutaneous coronary intervention ( PCI) in order to provide theoretical basis for regulating lipid treatment in clinic. Methods The data of 246 female patients with CHD before PCI were retrospectively analyzed. The patients were divided into STEMI group ( n - 56) and non-STEMI group ( n =190). According to the Syntax score, the patients were subdivided into 3 groups, light lesion group,moderate lesion group,and severe lesion group. The blood lipid levels before PCI were detected for all the groups. Results The mean age in STEMI group was significantly older than that in non- STEMI group ( P 0.05). As for non-STEMI group the levels of LP(a) in light lesion group were significantly lower than those in moderate lesion group ( P < 0. 05 ) ,and the levels of ApoB/ApoAI in light lesion group were significantly lower than those of severe lesion group ( P <0.05). Conclusion The LP(a) and Apo

  14. Blood Glucose Levels

    Directory of Open Access Journals (Sweden)

    Carlos Estela

    2011-01-01

    Full Text Available The purpose of this study was to establish a mathematical model which can be used to estimate glucose levels in the blood over time. The equations governing this process were manipulated with the use of techniques such as separation of variables and integration of first order differential equations, which resulted in a function that described the glucose concentration in terms of time. This function was then plotted, which allowed us to find when glucose concentration was at its highest. The model was then used to analyze two cases where the maximum glucose level could not exceed a certain level while the amount of carbohydrates and glycemic index were varied, independently.

  15. 城乡结合部健康体检者血糖血脂水平调查分析%Blood glucose and blood lipid level among rural-urban fringe zone people receiving health examination

    Institute of Scientific and Technical Information of China (English)

    李艳玲; 王翠侠

    2013-01-01

    Objective To understand the levels of blood glucose and blood lipid among rural-urban fringe zone people receiving health examination. Methods The data of blood glucose, triglyceride and cholesterol of 1416 people receiving health examination in our hospital were analyzed statistically. Results The average level of serum glucose, cholesterol increased with the age, the average level of triglyceride increased with the age before age 60, but declined after age 60. The prevalence rate of blood glucose abnormality, cholesterol abnormality and triglyceride abnormality was 16.38%, 49.08% and 27.47% respectively, and the abnormal rate of blood glucose, cholesterol, and triglyceride increased with the age. More males were detected to be abnormal with blood glucose and triglyceride than females, but the abnormal rate of cholesterol in males (52.69%) was significantly higher than in males (41.79%). The abnormal rate of cholesterol and triglycerides in males aged 40-50 years was significantly higher than in males of other age groups, but the abnormal rate of cholesterol and triglycerides in females aged 50-60 years was significantly increased and to the highest in 60-years old. Conclusion The prevalence rate of blood glucose abnormality, cholesterol abnormality, triglyceride abnormality is high, especially cholesterol abnormality. It is necessary to conduct regular examination of blood glucose and blood fat among the people with abnormal indicators. More attentions should be paid to the regular, healthy examination and lifestyle of residents in order to improve the peoples' healthy level.%目的 了解城乡结合部健康体检人群血糖和血脂状况.方法 对2011年1416名在东风社区卫生服务中心进行体检者的血糖、胆固醇和甘油三酯的检测结果进行统计分析.结果 体检者血糖、胆固醇平均水平随年龄的增长而增加;血糖、胆固醇、甘油三酯异常检出率分别为16.38%、49.08%、27.47%,随着年龄的增

  16. The effects of sertraline on blood lipids, glucose, insulin and HBA1C levels: A prospective clinical trial on depressive patients

    Directory of Open Access Journals (Sweden)

    Murat Kesim

    2011-01-01

    Conclusions: Sertraline-treated patients have to be followed up for blood insulin and triglyceride levels. In addition, their treatment plan needs to be adjusted as necessary to prevent possible metabolic changes.

  17. Activity assay of mangosteen (Garcinia mangostana L.) pericarp extract for decreasing fasting blood cholesterol level and lipid peroxidation in type-2 diabetic mice

    Science.gov (United States)

    Husen, Saikhu Akhmad; Winarni, Dwi; Khaleyla, Firas; Kalqutny, Septian Hary; Ansori, Arif Nur Muhammad

    2017-09-01

    This study aimed to explore the activity of pericarp extract of mangosteen (Garcinia mangostana L.). Mangosteen pericarp contains various active compounds which are beneficial for human health. In-vivo antioxidant assay of pericarp extract was carried out using 3-4 month male mice of strain BALB/c weighed 30-40 g. The mice were divided into two groups: normal control (KN) group and STZ-induced diabetic group. STZ induction was performed using multiple low-dose method 30 mg/kg body weight treated daily for five consecutive days. Diabetic group was separated into two subgroups: diabetic control (KD), metformin control (KM), and crude extract treatment subgroups. The fasting blood glucose and the cholesterol level were measured before and after lard treatment, we also did it on the first, seventh, and fourteenth day of mangosteen pericarp crude extract treatment. The mice were treated with mangosteen pericarp crude extract for 14 days. The MDA level of the fasting blood serum was measured. The body weight and fasting blood cholesterol level before and after lard treatment were analyzed by t-test, whereas, the fasting blood cholesterol and the MDA level were analyzed using one-way variant analysis continued with Duncan test. The correlation between the increasing body weight and the fasting blood cholesterol level was determined by Pearson correlation test. The results of the study showed that the administration of mangosteen pericarp crude extract was able to reduce the fasting blood cholesterol and the malondialdehide level significantly.

  18. Control study of levels of fasting blood glucose, blood lipid and cortisol in depression patients%抑郁症患者空腹血糖、血脂及皮质醇水平对照性研究

    Institute of Scientific and Technical Information of China (English)

    谢志兵; 王高华

    2014-01-01

    目的:了解抑郁症患者糖脂代谢以及应激情况。方法68例抑郁症患者作为抑郁症组,分别采用汉密顿抑郁量表(HAMD17)和汉密顿焦虑量表(HAMA14)、生活事件量表(LES)对患者情绪状况以及应激状况进行评定,监测其空腹血糖(FBG)、甘油三脂(TG)、血清总胆固醇(TC)、皮质醇(CO)水平,与40例对照组进行比较。结果抑郁症组的FBG、TG、CO水平显著高于对照组(P0.05);同时相关分析发现,抑郁症患者LES总分与FBG、CO水平呈正相关(P0.05). The results of related analysis showed that LES score of depression patients was positively correlated with levels of FBG and CO (P<0.05 or P<0.01), and the HAMA score, mental anxiety factors score and physical anxiety factors score were all positively correlated with level of TG. Conclusion The abnormal glucolipid metabolism of depression patients is related with their long-term mental stimulation. Therefore, clinicians ought to take early monitor on the patients’blood glucose, blood lipid and cortisol so as to provide timely treatment.

  19. Diagnostic value of blood lipids testing in patients with high-normal and subclinical levels of TSH in prevention and treatment of dislipoproteinemia

    Directory of Open Access Journals (Sweden)

    O D Rymar

    2010-12-01

    Full Text Available The purpose of the study is to evaluate character of lipid profile changes in Novosibirsk populational sample of men and women (45–69 years with subclinical and high-normal TSH levels. Current study was performed within the HAPIEE project “Determinants of cardiovascular diseases in Eastern Europe” of the Welcome Trust fond. Populational subsample of 280 subjects (125 men (44.6% and 155 women (55.4% was analyzed. Received data showed that high-normal TSH levels within 1.71–4.05 mIU/l have been associated with higher levels of triglycerides, total cholesterol and LDL cholesterol, compared with low-normal TSH levels 0.17–0.47 mIU/l (р<0.05. Women with subclinical hypothyroidism had significantly higher average levels of total cholesterol and LDL cholesterol compared with women without thyroid disorders.

  20. Blood lead levels and chronic blood loss

    Energy Technology Data Exchange (ETDEWEB)

    Manci, E.A.; Cabaniss, M.L.; Boerth, R.C.; Blackburn, W.R.

    1986-03-01

    Over 90% of lead in blood is bound to the erythrocytes. This high affinity of lead for red cells may mean that chronic blood loss is a significant means for excretion of lead. This study sought correlations between blood lead levels and clinical conditions involving chronic blood loss. During May, June and July, 146 patients with normal hematocrits and red cell indices were identified from the hospital and clinic populations. For each patient, age, race, sex and medical history were noted, and a whole blood sample was analyzed by flameless atomic absorption spectrophotometry. Age-and race-matched pairs showed a significant correlation of chronic blood loss with lead levels. Patients with the longest history of blood loss (menstruating women) had the lowest level (mean 6.13 ..mu..g/dl, range 3.6-10.3 ..mu..g/dl). Post-menopausal women had levels (7.29 ..mu..g/dl, 1.2-14 ..mu..g/dl) comparable to men with peptic ulcer disease, or colon carcinoma (7.31 ..mu..g/dl, 5.3-8.6 ..mu..g/dl). The highest levels were among men who had no history of bleeding problems (12.39 ..mu..g/dl, 2.08-39.35 ..mu..g/dl). Chronic blood loss may be a major factor responsible for sexual differences in blood lead levels. Since tissue deposition of environmental pollutants is implicated in diseases, menstruation may represent a survival advantage for women.

  1. Why control blood glucose levels?

    Science.gov (United States)

    Rossini, A A

    1976-03-01

    The controversy as to the relationship between the degree of control of diabetes and the progression of the complications of the disease has not been solved. However, in this review, various studies suggesting a relationship between the metabolic abnormality and the diabetic complications are examined. The disadvantages of the uncontrolled diabetes mellitus can be divided into two major categories-short-term and long-term. The short-term disadvantages of controlled diabetes mellitus include the following: (1) ketoacidosis and hyperosmolar coma; (2) intracellular dehydration; (3) electrolyte imbalance; (4) decreased phagocytosis; (5) immunologic and lymphocyte activity; (6) impairment of wound healing; and (7) abnormality of lipids. The long-term disadvantages of uncontrolled diabetes melitus include the following: (1) nephropathy; (2) neuropathy; (3) retinopathy; (4) cataract formation; (5) effect on perinatal mortality; (6) complications of vascular disease; and (7) the evaluation of various clinical studies suggesting the relationship of elevated blood glucose levels and complications of diabetes mellitus. It is suggested that until the question of control can absolutely be resolved, the recommendation is that the blood glucose levels should be controlled as close to the normal as possible.

  2. 老年人运动与血脂、血糖关系的调查分析%Relationship of regular physical exercise with blood lipid and blood glucose levels in the elderly

    Institute of Scientific and Technical Information of China (English)

    白洁; 拓西平; 张文俊

    2011-01-01

    目的 探讨老年人运动与血脂、血糖的关系.方法 选择2007年4月至2009年4月来医院体检的未服用降脂药物的420名干休所老年人为研究对象,按是否规律运动分为经常运动组(n=352)及少运动组(n=68).收集两组运动情况、糖尿病患病率等相关资料,并检测两组血清中总胆同醇、甘油三酯、低密度脂蛋白胆同醇、高密度脂蛋白胆同醇、空腹血糖的水平.结果 正常运动组老年人甘油三酯、总胆固醇、高密度脂蛋白胆同醇、低密度脂蛋白胆同醇、空腹血糖均低于少运动组老年人.正常运动组老年人的糖尿病患病率明显低于少运动组老年人.结论 长期规律的运动可使老年人血脂水平向有益于健康方向变化,并降低糖尿病发生风险.%Objective To investigate the relationship of regular exercise with blood lipid and glucose levels in the elderly. Methods A total of 420 veteran cadres from Veteran Homes in Shanghai, aging from 60 to 89 years old, who visited hospital for routine physical examination from April 2007 to April 2009, were included. They were divided into frequent exercise group (n=352) and seldom exercise group (n=68) according to the exercise frequency. The information of the subjects, including exercise strength, and morbidity of type 2 diabetes mellitus (T2DM), were collected. In addition, plasma levels of triglyceride (TG), total cholesterol(TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting blood glucose (FBG) were examined. Results The plasma levels of TG, TC, LDL-C, HDL-C and FBG were significantly lower in frequent exercise group than in seldom exercise group. The morbidity of T2DM was lower in frequent exercise group than in seldom exercise group. Conclusion Regular physical exercise is helpful in controlling blood lipid levels, and decreasing the risk of T2DM in elderly individuals.

  3. Effect of Kombucha Tea on Blood Sugar and Blood Lipid Profiles in Diabetic Rats: Short Communication

    Directory of Open Access Journals (Sweden)

    Mohammad Malekaneh

    2015-07-01

    Full Text Available Background and Aim: Kombucha tea is made through fermentation of sweet tea by Kombucha fungus. It has beneficial therapeutic effects in the treatment of many diseases. The present study aimed at examining the effect of Kombucha tea extract on blood sugar and blood lipid profiles in diabetes. Materials and Methods: Twenty-eight Wistar rats weighing about 250g were divided into 4 equal groups and then injected intraperitoneally (IP with alloxan to induce diabetes. The administered concentrations were 20 and 80 mg/kg of Kombucha tea and 20 mg/kg of black ordinary tea for one month. The rats’ blood sugar and weight were tested before and after the intervention period but blood lipid parameters per either administration were also assessed at the end of the period. Results: Mean blood sugar in the diabetic rats receiving Kombucha tea was reduced. Maximum reduction in blood sugar was observed in the group receiving Kombucha tea with concentration of 80 mg/kg. However, black tea significantly reduced blood sugar. Conclusion: Kombucha tea consumption for a month only reduced blood sugar levels in diabetic patients. But increased the weight and not have favorable effects on lipid profile.

  4. The long-term effects of pitavastatin on blood lipids and platelet activation markers in stroke patients: impact of the homocysteine level.

    Directory of Open Access Journals (Sweden)

    Hideki Sugimoto

    Full Text Available To examine the impact of the plasma homocysteine level on the anti-atherosclerotic effects of pitavastatin treatment, we retrospectively examined 59 patients who had a history of stroke and had been prescribed pitavastatin for the treatment of dyslipidemia at the Neurology department of Toho University Ohashi Medical Center Hospital. The patients were classified into two groups according to their homocysteine levels. Carotid artery plaque progression was determined before and after pitavastatin treatment. Plasma levels of high-sensitivity C-reactive protein, platelet molecular markers, and von Willebrand factor were measured. Pitavastatin treatment had beneficial effects on the lipid profiles of these patients and slowed atherosclerosis progression. These effects were observed in both the high and low homocysteine groups. Proactive lipid intervention using pitavastatin may inhibit the progression of atherosclerosis and contribute to secondary prevention of stroke in high-risk patients. We conclude that this statin could inhibit progression at any stage of disease and should therefore be proactively administered to these patient groups, regardless of disease severity.

  5. Analysis on correlation among the level of serum glycosylated hemoglobin, blood glucose and blood lipid in the elderly diabetes patients%老年糖尿病患者糖化血红蛋白、血糖及血脂的相关性分析

    Institute of Scientific and Technical Information of China (English)

    詹德尚

    2014-01-01

    Objective To investigate the relationships among the level of serum glycosylated hemoglobin, blood glucose and blood lipid in the elderly diabetes patients. Methods 112 elderly diabetes patients and 102 elderly healthy physical examination people in our hospital from September 2009 to March 2013 were selected as the study objects. The level of serum glycosylated hemoglobin, blood glucose and blood lipid in patients were detected, and the relationships among the level of serum glycosylated hemoglobin, fasting blood glucose, 2h postprandial blood glucose, blood lipid were compared. Results There were statistical difference in the level of serum glycosylated hemoglobin, blood glucose and blood lipid between the diabetes patients and control group(P < 0.05); The level of serum glycosylated hemoglobin and fasting blood glucose, 2h postprandial blood glucose and blood lipid had positive correlation(P < 0.05). Conclusion The level of serum glycosylated hemoglobin, blood glucose and blood lipid in the elderly diabetes patients are obviously higher than those in normal physical examination people, and the level rise of glycosylated hemoglobin and blood glucose level, blood lipid level in patients have a certain correlation, and the detection of serum glycated hemoglobin has an important significance for the evaluation of control effect of blood glucose and blood lipid.%目的:探讨老年糖尿病患者血清糖化血红蛋白、血糖以及血脂水平之间的关系。方法选择2009年9月~2013年3月期间,于我院接受治疗的112例老年糖尿病患者及102例老年健康体检者作为研究对象,检测患者血清糖化血红蛋白与血糖及血脂,比较糖化血红蛋白与患者空腹血糖、餐后2h血糖、血脂之间的关系。结果糖尿病患者糖化血红蛋白、血糖及血脂与对照组比较,差异有统计学意义(P<0.05);糖尿病患者糖化血红蛋白与空腹血糖、餐后2h血糖及血

  6. Correlation investigation of glucose level with blood lipid level in inpatients with type 2 diabetes%住院2型糖尿病患者血糖水平和血脂水平相关性研究

    Institute of Scientific and Technical Information of China (English)

    卢冰; 方玲娜; 钟绍; 沈鲜安; 朱文华

    2013-01-01

    Objective To investigate the correlation of glucose level with blood lipid level in patients with type 2 diabetes.Methods The level of GLU,TG,TC,HDL-C and LDL-C,Apo A1,ApoB and Apo(a) of 344 inpatients with type 2 diabetes (T2DM group) and 80 healthy person (contuol group)were measured,then the results were compared and analyzed.Results The level of TG,TC,LDL-C,ApoB,Apo(a) of T2DM group was significantly higher than than those of control group,and level of HDL-C,ApoA was significantly lower than that of control group,the difference was significant (P < 0.05).With glucose level increasing,the level of TG,TC,LDL-C,ApoB and Apo(a) increased accordingly,the level of HDL-C and ApoA1 decrease accordingly,and level of TG,TC,LDL-C,ApoB and Apo (a) had positive correlation with glucose level,correlation coefficients r were 0.148,0.180,0.141,0.218,0.250(P <0.01).Conclusions Each index level of blood lipid of inpatients with type 2 diabetes has significant difference with normal control group and has certain correlation with glucose level,this is maybe the reason that lead to cardiovascular complications of patients with type 2 diabetes.%目的 探讨住院2型糖尿病患者血糖水平与血脂水平之间的关系.方法 测定344例住院2型糖尿病患者(T2DM组)和80例健康体检者(对照组)空腹血糖(GLU)水平和三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白(a)[Apo(a)]水平,并对结果进行比较分析.结果 T2DM组TG、TC、LDL-C、ApoB、Apo(a)水平明显高于对照组,HDL-C、ApoA1水平明显低于对照组,差异有统计学意义(P<0.05);随着血糖升高,TG、TC、LDL-C、ApoB、Apo(a)水平相应的升高,HDL-C、ApoA1水平相应下降,其中TG、TC、LDL-C、ApoB、Apo(a)水平与血糖水平呈正相关,相关系数r分别为0.148、0.180、0.141、0.218、0.250(P<0.01).结论 2型糖尿病患者血脂各项指

  7. Blood Lipids and other Related Risk Factors of stroke

    Institute of Scientific and Technical Information of China (English)

    Liu YAND; Hiu Lu

    2000-01-01

    Abstract To assess the ralationship between incidence of stroke and blood lipids, apolipoprolcin (apo) , 219 patients with stroke(cerebral hemorrhage 87, cerebral infarction 132) , diagnosed with the aid of CT, were examined. The levels of serum total cholesterol, triglycerioes, apo-A, apo-B were calculatea. 160 cases with no disorder in metabolism of blood lipids or other disease of meurologic system were taken as centrol group. The results zhowed that the ratio of high density lipoprotein cholesterol and low clensity lipoprotein cholesterol was iower than.that of control group(p<0. 05) . In the patients group, cases with diabetes, hypentension coronary heart disease or onesity, the levels of blood liprds. triglyceride and cholesterol were higher than those vithout above mentioned disease The condusion is, that there is certain reletionship between the contents of bliid lipids. lipoprotein and it sulqraction HDL2, HDL3 and cerebrovasculor cisease. The radis of high density lipoprotein and low density lipoprolein is the important factor in predicting of stroke

  8. Effect of Jiaosanxian on Reducing Blood Lipid

    Institute of Scientific and Technical Information of China (English)

    YIN Ai-wu; TIAN Run; ZHAO Jiao

    2013-01-01

    Objective To investigate the effects of Jiaosanxian (JSX,consisted of stir-baked Hordei Fructus Germinatus-Crataegi Fructus-Massa Fermentata Medicinalis) on reducing blood lipid.Methods The model of hyperlipidemic mice was established by feeding high-fat diet.Kunming mice were randomly divided into six groups:blank,hyperlipidemic,Zhibituo,low-,mid-,and high-dose [100,200,and 400 mg/(kg·d)] JSX groups,and were continuously ig administered for 28 d.The contents of total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),and high density lipoprotein cholesterol (HDL-C) in serum and liver and liver index were determined.Results The contents of TC,TG,and LDL-C in serum or liver were decreased significantly but the contents of HDL-C were increased more significantly in the mid-and high-dose JSX groups than those in hyperlipemic group.The weight and liver index were decreased significantly with the dose increasing of JSX.The lipid-decreasing effects were improved with the dose increasing.Conclusion These results suggest that JSX has the significant effects on hyperlipidemia.It could provide the experimental basis for the clinical use of JSX for the treatment of hyperlipidemia.

  9. Effect of sugarcane vinegar on blood lipid level in hyperlipidaemic patients%甘蔗醋对高血脂患者血脂水平影响的临床探讨

    Institute of Scientific and Technical Information of China (English)

    Binay Kumar Adhikari; 高敏捷; 孟晓萍

    2013-01-01

    Objective:To discuss the effect of sugarcane vinegar on blood lipid level in hyperlipidaemic patients. Method:121 patients from out patient department of second hospital were randomly divided into two groups:50 cases in lipitor group who received 20mg lipitor per day and another group was sugarcane vinegar group with 71 cases who received 15ml vinegar two times a day. After a month, blood lipid was tested again. Result:lipitor decreases blood LDL level, which is significantly greater than vinegar group. Vinegar increases blood HDL level which is slightly greater than lipitor but of no statistical significance. Conclusion:from diet point of view, sugar cane vinegar has role in decreasing blood lipid, simultaneouly role of increasing HDL, which has specific significance in preventing increase of blood lipid and hence atherosclerosis.%目的:探讨甘蔗醋对高血脂患者血脂水平的影响。方法:121名患者来自于吉大二院门诊,随机分为两组,立普妥组:50例患者每天接受立普妥(20 mg)治疗。另一组每天甘蔗醋组:71例患者饮用甘蔗醋15ml 每天两次。一个月后再检测患者血脂。结果:立普妥组降低血LDL 水平明显大于甘蔗醋组。甘蔗醋提高 HDL 的作用比立普妥略为升高但无统计学意义。结论:从饮食的角度甘蔗醋有降脂的作用并有提高 HDL 的作用。对预防血脂增高及动脉粥样硬化方面具有一定的意义。

  10. Influence of Simvastatin for In-stent Restenosis Rate and Blood Lipid Level and Inflammation Actor after Coronary Artery Stent Implantation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    To investigate the effect of simvastatin on the probability of restenosis after stent implantation and serum level of lipids as well as high-sensitivity C-reactive protein (hs-CRP) in patients with coronary heart disease (CHD).Methods 118 patients with CHD after stenting therapy were divided into treatment group (n = 62) and control group(n =56) randomly. All patients were treated withaspirin (100 mg/d) and clopidogrel (75 mg/d) while treatment group patients took simvastatin (40 mg qn) additionally. All patients underwent coronary angiography (CAG) to compare the difference of restenosis and the serum level of total cholesterol (TC), low-density lipoprotein cholesterol(LDL-c), high-density lipoprotein cholesterol (HDL-c), triglyceride (TG) as well as hs-CRP after the drug treatment for 6 months. Results The probability of restenosis was significantly lower in the treatment group than that of control group ( P < 0.01 ) and the results were similar between the patients with bare metal stent ( P < 0.01 ) and those with sirolimus-eluting stent ( P<0.01 ). The serum levels of TC (P<0.01 ), LDL-c( P<0.01 ), TG (P<0.05 ) and hsCRP (P<0.01) were obviously lower while the HDL-c (P<0.05 ) level was higher in the treatment group than those of control group. There was no death case. Conclusions Simvastatin could decrease the probability of restenosis significantly after coronary stent implantation with dose of 40 mg/d. It also has good performance on lipids control and lightening inflammatory reactions with its undoubtedly safety.

  11. Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study

    DEFF Research Database (Denmark)

    Zhang, L.; Qiao, Q.; Tuomilehto, J.

    2008-01-01

    OBJECTIVE: Dyslipidaemia is present not only in diabetic but also in prediabetic subjects. The purpose of this study is to investigate the relationship between lipid and glucose levels in a large European population without a prior history of diabetes. RESEARCH DESIGN AND METHODS: Data from....... RESULTS: In subjects without a prior history of diabetes, positive relationships were shown between fasting plasma glucose (FPG) and total cholesterol (TC) (beta=0.06 and 0.03, respectively for men and women, p... cholesterol (non-HDL-C) (beta=0.06 and 0.03, pHDL ratio (beta=0.06 and 0.05, pHDL-C (beta=-0.02, p>0.05 in men and beta=-0.03, p

  12. Prevalence of Abnormity of Blood Lipid and Associated Factors in Health Examination Population in Beijing

    Institute of Scientific and Technical Information of China (English)

    Wei-ming Kang; Jie-shi Zhang; Xin-xin Liu; Min-shan Wang; Ming-li Zhao; Jian-chun Yu

    2009-01-01

    Objective To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing.Methods Totally,38462 individuals who received health examination were enrolled in our study.We divided them into eight groups according to their ages.The levels of serum total cholesterol,triglyceride,high density lipoprotein cholesterol,and low density lipoprotein cholesterol were tested,and the relationship of blood lipid abnormity with body mass index(BMI)and fasting blood glucose was analyzed.Results The incidences of hypercholesterolemia,hyperglyceridemia,low high-density lipoprotein cholesterolemia,and hyper low-density lipoprotein cholesterolemia presented increasing trend in this population.The incidence rate of abnormity of blood lipid in health examination population increased with BMI increase.The incidence of abnormity of blood lipid in overweight and obesity population was significantly higher than that in low weight and normal weight populations(P<0.05).Meanwhile,the trend of abnormal blood lipid incidence coincided with that of abnormal fasting blood glucose.Conclusions The prevalence of overweight,obesity,and abnormity of blood lipid in Beijing presents increasing trend.The incidence of abnormity of blood lipid increases with BMI increase,in coincidence with that of fasting blood glucose.

  13. Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan.

    Science.gov (United States)

    Shahid, Saleem Ullah; Rehman, Abdul

    2017-07-01

    Nitric oxide is an important antiatherosclerotic agent. The main determinant of nitric oxide levels is enzyme nitric oxide synthase encoded by the NOS3 gene, the common variants in this gene may be responsible for variations in plasma enzyme levels. The association of NOS3 variants with coronary artery disease (CAD) varies in different ethnicities. The current study aimed to determine the association of NOS3 Glu298Asp (rs1799983) with CAD and blood lipid levels in Pakistani subjects. Six hundred thirty-six samples (412 cases, 224 controls) were genotyped by TaqMan allelic discrimination assay and serum total cholesterol, and High Density Lipoprotein cholesterol (HDL-C)/Low Density Lipoprotein cholesterol (LDL-C) and triglycerides were measured. The genotype frequency was Glu/Glu = 64.6%, Glu/Asp = 30.1%, and Asp/Asp = 5.3% in cases, and Glu/Glu = 68.8%, Glu/Asp = 26.7%, and Asp/Asp = 4.5% in controls. The Asp298 (T) frequency was not significantly higher in cases than controls (20.4% vs 17.9%, P = 0.28) and risk allele was not associated with CAD (OR 1.15 (0.86-1.54), P = 0.33) and the tested lipid traits but had a strong association with blood pressure (for systolic and diastolic P = 1.9×10(--56) and 4×10(--40) , respectively). In conclusion, although Glu298Asp did not show association with CAD and lipid profile in the studied cohort, it may exert its effect through blood pressure; however, the mechanism of this effect needs to be explored in the future. © 2017 John Wiley & Sons Ltd/University College London.

  14. 广东省成年体检人群异常血脂水平分布情况调查%Investigation of the distribution of abnormal blood lipid levels of health examination adults of all ages in Gangdong

    Institute of Scientific and Technical Information of China (English)

    李华; 魏莲; 陈佑明; 黄敬; 刘铁连; 刘京平

    2013-01-01

    OBJECTIVE To investigate the distribution of abnormal blood lipid levels of health examination adults in Guangdong Province. METHODS We investigated and statistically analyzed abnormal blood lipid levels of 28 447 people the age of 20 years and over during period of November 2009 and November 2010 in Guangdong Province. Investigated health examination adult at different ages and gender, and abnormal blood lipid composition. According to abnormal blood lipid sample, there were three groups including only high total cholesterols (group A) ; only high triglycerides (group B) ; both high total cholesterol and triglyceride (group C). RESULTS There were significantly age differences in the proportion of abnormal blood lipid levels in the other age groups (P = 0.000) , except the abnormal blood lipid level of age group of 50- years without gender differences ; And there were significant gender differences (P ≤ 0.05) in the composition of lipid abnormalities of male and female in other ages' groups, including in group A and group B, group A and group C group B and group C, except in 20- and over 40- age groups between group B and C; And there were significant differences {P - 0.000) of the composition of lipid abnormalities on genders between three groups; also there was a different distribution of abnormal blood lipid composition of men and women of all ages. CONCLUSION There are significantly differences on the composition of lipid abnormalities, ages and genders of Guangdong adult medical health examination groups of all ages, also there are significant differences in the incidence rate of abnormal blood lipid and proportion of mixed one of female in the 50-year-old, which is highly above male with the same age, and also highly above other ages female, suggesting that postmenopausal female should pay attention to regular blood checks, for which helps prevent and reduce the incidence of cardiovascular disease.%目的 调查广东省成年体检人群各年龄段男女

  15. Discovery and Refinement of Loci Associated with Lipid Levels

    Science.gov (United States)

    Peloso, Gina M.; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; Buchkovich, Martin L.; Mora, Samia; Beckmann, Jacques S.; Bragg-Gresham, Jennifer L.; Chang, Hsing-Yi; Demirkan, Ayşe; Den Hertog, Heleen M.; Do, Ron; Donnelly, Louise A.; Ehret, Georg B.; Esko, Tõnu; Feitosa, Mary F.; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; Fraser, Ross M.; Freitag, Daniel F.; Gurdasani, Deepti; Heikkilä, Kauko; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne U.; Johansson, Åsa; Johnson, Toby; Kaakinen, Marika; Kettunen, Johannes; Kleber, Marcus E.; Li, Xiaohui; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K.E.; Mangino, Massimo; Mihailov, Evelin; Montasser, May E.; Müller-Nurasyid, Martina; Nolte, Ilja M.; O’Connell, Jeffrey R.; Palmer, Cameron D.; Perola, Markus; Petersen, Ann-Kristin; Sanna, Serena; Saxena, Richa; Service, Susan K.; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; Strawbridge, Rona J.; Surakka, Ida; Tanaka, Toshiko; Teslovich, Tanya M.; Thorleifsson, Gudmar; Van den Herik, Evita G.; Voight, Benjamin F.; Volcik, Kelly A.; Waite, Lindsay L.; Wong, Andrew; Wu, Ying; Zhang, Weihua; Absher, Devin; Asiki, Gershim; Barroso, Inês; Been, Latonya F.; Bolton, Jennifer L.; Bonnycastle, Lori L; Brambilla, Paolo; Burnett, Mary S.; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S.F.; Döring, Angela; Elliott, Paul; Epstein, Stephen E.; Ingi Eyjolfsson, Gudmundur; Gigante, Bruna; Goodarzi, Mark O.; Grallert, Harald; Gravito, Martha L.; Groves, Christopher J.; Hallmans, Göran; Hartikainen, Anna-Liisa; Hayward, Caroline; Hernandez, Dena; Hicks, Andrew A.; Holm, Hilma; Hung, Yi-Jen; Illig, Thomas; Jones, Michelle R.; Kaleebu, Pontiano; Kastelein, John J.P.; Khaw, Kay-Tee; Kim, Eric; Klopp, Norman; Komulainen, Pirjo; Kumari, Meena; Langenberg, Claudia; Lehtimäki, Terho; Lin, Shih-Yi; Lindström, Jaana; Loos, Ruth J.F.; Mach, François; McArdle, Wendy L; Meisinger, Christa; Mitchell, Braxton D.; Müller, Gabrielle; Nagaraja, Ramaiah; Narisu, Narisu; Nieminen, Tuomo V.M.; Nsubuga, Rebecca N.; Olafsson, Isleifur; Ong, Ken K.; Palotie, Aarno; Papamarkou, Theodore; Pomilla, Cristina; Pouta, Anneli; Rader, Daniel J.; Reilly, Muredach P.; Ridker, Paul M.; Rivadeneira, Fernando; Rudan, Igor; Ruokonen, Aimo; Samani, Nilesh; Scharnagl, Hubert; Seeley, Janet; Silander, Kaisa; Stančáková, Alena; Stirrups, Kathleen; Swift, Amy J.; Tiret, Laurence; Uitterlinden, Andre G.; van Pelt, L. Joost; Vedantam, Sailaja; Wainwright, Nicholas; Wijmenga, Cisca; Wild, Sarah H.; Willemsen, Gonneke; Wilsgaard, Tom; Wilson, James F.; Young, Elizabeth H.; Zhao, Jing Hua; Adair, Linda S.; Arveiler, Dominique; Assimes, Themistocles L.; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Boehm, Bernhard O.; Boomsma, Dorret I.; Borecki, Ingrid B.; Bornstein, Stefan R.; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C.; Chen, Yii-Der Ida; Collins, Francis S.; Cooper, Richard S.; Danesh, John; Dedoussis, George; de Faire, Ulf; Feranil, Alan B.; Ferrières, Jean; Ferrucci, Luigi; Freimer, Nelson B.; Gieger, Christian; Groop, Leif C.; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B.; Hingorani, Aroon; Hirschhorn, Joel N.; Hofman, Albert; Hovingh, G. Kees; Hsiung, Chao Agnes; Humphries, Steve E.; Hunt, Steven C.; Hveem, Kristian; Iribarren, Carlos; Järvelin, Marjo-Riitta; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Kesäniemi, Antero; Kivimaki, Mika; Kooner, Jaspal S.; Koudstaal, Peter J.; Krauss, Ronald M.; Kuh, Diana; Kuusisto, Johanna; Kyvik, Kirsten O.; Laakso, Markku; Lakka, Timo A.; Lind, Lars; Lindgren, Cecilia M.; Martin, Nicholas G.; März, Winfried; McCarthy, Mark I.; McKenzie, Colin A.; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; Morris, Andrew D.; Munroe, Patricia B.; Njølstad, Inger; Pedersen, Nancy L.; Power, Chris; Pramstaller, Peter P.; Price, Jackie F.; Psaty, Bruce M.; Quertermous, Thomas; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; Sanghera, Dharambir K.; Saramies, Jouko; Schwarz, Peter E.H.; Sheu, Wayne H-H; Shuldiner, Alan R.; Siegbahn, Agneta; Spector, Tim D.; Stefansson, Kari; Strachan, David P.; Tayo, Bamidele O.; Tremoli, Elena; Tuomilehto, Jaakko; Uusitupa, Matti; van Duijn, Cornelia M.; Vollenweider, Peter; Wallentin, Lars; Wareham, Nicholas J.; Whitfield, John B.; Wolffenbuttel, Bruce H.R.; Ordovas, Jose M.; Boerwinkle, Eric; Palmer, Colin N.A.; Thorsteinsdottir, Unnur; Chasman, Daniel I.; Rotter, Jerome I.; Franks, Paul W.; Ripatti, Samuli; Cupples, L. Adrienne; Sandhu, Manjinder S.; Rich, Stephen S.

    2013-01-01

    Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, and total cholesterol are heritable, modifiable, risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,578 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5×10−8, including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian, and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipids are often associated with cardiovascular and metabolic traits including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio, and body mass index. Our results illustrate the value of genetic data from individuals of diverse ancestries and provide insights into biological mechanisms regulating blood lipids to guide future genetic, biological, and therapeutic research. PMID:24097068

  16. Nuts, blood lipids and cardiovascular disease.

    Science.gov (United States)

    Sabaté, Joan; Wien, Michelle

    2010-01-01

    The aim of this paper is to evaluate nut-related epidemiological and human feeding study findings and to discuss the important nutritional attributes of nuts and their link to cardiovascular health. Frequent nut consumption has been found to be protective against coronary heart disease in five large epidemiological studies across two continents. A qualitative summary of the data from four of these studies found an 8.3% reduction in risk of death from coronary heart disease for each weekly serving of nuts. Over 40 dietary intervention studies have been conducted evaluating the effect of nut containing diets on blood lipids. These studies have demonstrated that intake of different kinds of nuts lower total and LDL cholesterol and the LDL: HDL ratio in healthy subjects or patients with moderate hypercholesterolaemia, even in the context of healthy diets. Nuts have a unique fatty acid profile and feature a high unsaturated to saturated fatty acid ratio, an important contributing factor to the beneficial health effects of nut consumption. Additional cardioprotective nutrients found in nuts include vegetable protein, fiber, alpha-tocopherol, folic acid, magnesium, copper, phytosterols and other phytochemicals.

  17. EFFECT OF KIMCHI INTAKE ON LIPID PROFILES AND BLOOD PRESSURE

    Directory of Open Access Journals (Sweden)

    Hyun Ju Kim

    2012-06-01

    Full Text Available Kimchi is a Korean fermented vegetable and has recognized as a healthy food. Some interventional studies have reported an inverse association between kimchi intake and higher lipid levels in healthy and obese people. However, kimchi intake and hypertention were still uncertain. This study is carried out to investigate whether the serum lipid profiles and blood pressure would be influenced by the amount of kimchi intake. Design for the clinical study by controlling the meal consumption and physical activity of the subjects for 7 days was approved by IRB at P Hospital (No.2011075. For the study, 100 volunteers assigned into 2 groups, low (15 g/day, n=50 and high kimchi intake group (210 g/day, n=50, temporarily stayed together at the dormitory during the 7-day experimental period. Three meals with different amount of kimchi were provided and subjects were asked to maintain the normal physical activity as usual. Significant decrease in the concentration of fasting blood glucose, TG, total-C, and LDL-C for the both group was observed after 7 days of kimchi intake regardless of amount of kimchi intake. Only FBG suppression effect was significantly different (p<0.01. Furthermore, people with hypercholesterolemia (≤19 mg/dL showed greater improvements in total cholesterol levels in high kimchi intake group. One notable finding in this study was that urinary Na excretion for the high kimchi intake group was significantly increased (p<0.05. There was no significant difference in the BP reductions by kimchi intake. Higher intake of kimchi appears to be a modest beneficial effect to lipid lowering, without any effect on blood pressure in spite of increased sodium excretion. Long-term study should be clarified whether kimchi intake associated with hypertension.

  18. Lipid Profile and Leptin Levels in Patients with Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    This paper should be cited as: Esmaeili R, Hassanzadeh, T . [ Lipid Profile and Leptin Levels in Patients with Metabolic Syndrome ]. mljgoums . 201 4 ; 8 ( 3 : 23 - 29 [Article in Persian] Esmaeili, R.

    2014-09-01

    Full Text Available Background and Objective: Metabolic syndrome called a cluster of several metabolic disorders is associated with increased risk of cardiovascular diseases. Genetic differences in leptin receptor gene are related with the concentration and activity of leptin in that these discrepancies can influence lipid levels. We aimed to determine the association between the leptin receptor gene polymorphism on serum lipid profile and leptin activity in metabolic syndrome patients. Material and Methods: This case-control study was conducted on 200 patients with metabolic syndrome and 200 healthy individuals. Polymerase Chain Reaction (PCR and Restriction Fragment Length Polymorphisms (RFLP were used to determine genotypic distribution and allelic frequencies of polymorphisms, respectively. The plasma leptin activity was measured by a kit in a fluorescence spectrometer, and Lipid concentration by routine biochemical and enzymatic assays. Results: Two groups had significant differences in all measured factors such as lipid profiles, fast blood sugar, waist circumference, blood pressure and leptin concentration (P< 0.05. Conclusion: Given that the two groups had significant differences in blood and body measurements, no role of K656N polymorphism was observed. Overall, Lys656Asn (K656N polymorphism of leptin receptor gene is not associated with serum lipid profile and leptin activity with metabolic syndrome.

  19. 太极拳运动对中老年人高血压和血脂水平的影响%Effect of Tai Chi on the hypertension and blood lipid level among middle-aged people

    Institute of Scientific and Technical Information of China (English)

    靳振洋

    2012-01-01

    目的 研究太极拳运动对中老年人血脂和血压状态的影响,了解太极拳对中老年人的身体状态产生的积极作用.方法 选取某院进行保守治疗的80例高血压病人且患者的血脂异常作为病例组,对患者进行为期6个月的太极拳锻炼,测量患者锻炼前后的血压和锻炼前后的血脂水平并进行比较.结果 太极拳组患者进行锻炼后血压指标得到明显改善,与锻炼前相比差异具有统计学意义;且太极拳组患者的血脂各项指标经过锻炼后与锻炼前指标具有明显改善,差异具有统计学意义.结论 太极拳运动能明显改善中老年高血压患者的血压状况,缓解高血压进展;同时,进行太极拳锻炼能改善高血压患者的血脂异常水平,对患者身体产生积极的作用.%OBJECTIVE To study the Tai Chi on the hypertension and blood tipid level among middle-aged people, and understand the effect of Tai Chi on the physical quality of middle-aged people. METHODS A total of 80 hypertension cases with conservation treatment were collected from our hospital, and were taken 6 years Tai Chi treatment, and the hypertension and blood Lipid were compared before and after intervention. RESULTS The hypertension was significandy improved after intervention with Tai Chi, and there was a significant difference between before and after intervention. The blood lipid level was significantly improved after intervention, and there was a significant difference before and after intervention. CONCLUSION Tai Chi could significantly improve the hypertension among middle-aged people, and decrease the progress of hypertension. Meanwhile, Tai Chi could improve the blood lipid level among hypertension cases, and improve the quality of life.

  20. Genetic architecture of circulating lipid levels

    DEFF Research Database (Denmark)

    Demirkan, Ayşe; Amin, Najaf; Isaacs, Aaron

    2011-01-01

    the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independent population-based study, the Rotterdam Study-II (RS-II). We additionally tested for evidence of a shared genetic basis for different lipid phenotypes. Finally, the polygenic score approach was used to identify...... levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from...... suggested a small overlap between the polygenic backgrounds involved in determining LDL-C, HDL-C and TG levels. Pathway analysis utilizing the best polygenic score for TC uncovered extra information compared with using only genome-wide significant loci. These results suggest that the genetic architecture...

  1. The relationship research of MPV and blood lipid level with sudden deafness%平均血小板体积和血脂与突发性耳聋的关系探讨

    Institute of Scientific and Technical Information of China (English)

    张建国; 李治锋; 吴永先

    2016-01-01

    Objective To investigate the mean platelet volume (MPV) and blood lipid level change and the relationship with sudden deafness (SD). Methods 115 cases SD patients and 116 cases of healthy people in our hospital from January 2014 to December 2015 were collected in the study. SD patients were di-vided into mild deafness group, moderately severe deafness group and severe deafness group. The blood lipid and MPV levels of all the subjects were detected, and the results were analyzed statistically. Results The lev-els of MPV, total cholesterol, low-density lipoprotein cholesterol, lipoprotein(a) in patients with SD were sig-nificantly higher than that of control group, high-density lipoprotein cholesterol was significantly lower than that of control group, and the differences all had statistical significance (Pall0.05). There were no statistical significance in the differences of MPV and blood lipid parameters levels among three different level SD groups (Pall>0.05). Conclusion MPV and lipid levels are closely associated with the onset of SD, which providing the basis for the clinical pathogenesis of SD. MPV and lipid levels detection can predict the risk of SD.%目的探讨平均血小板体积(mean platelet volume, MPV)和血脂水平变化与突发性耳聋(sudden deafness, SD)的关系。方法收集2014年1月至2015年12月我院115例SD患者和116例健康体检者,将SD患者分为中度耳聋、中重度耳聋、重度耳聋三组,检测所有受试者的血脂和MPV水平,对检测结果进行统计学分析。结果 SD患者组的MPV、总胆固醇、低密度脂蛋白胆固醇、脂蛋白a水平均显著高于对照组,高密度脂蛋白胆固醇水平显著低于对照组,差异均有统计学意义(P均<0.01),甘油三酯水平在两组间差异无统计学意义(P>0.05);不同程度耳聋患者的MPV和血脂各参数之间差异均无统计学意义(P均>0.05)。结论 MPV和血脂水平与SD发病密切相关

  2. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels

    Science.gov (United States)

    ... to Be Smart About Social Media Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar Print A ... Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar levels ( ...

  3. Lysophosphatidylcholines: bioactive lipids generated during storage of blood components.

    Science.gov (United States)

    Maślanka, Krystyna; Smoleńska-Sym, Gabriela; Michur, Halina; Wróbel, Agnieszka; Lachert, Elżbieta; Brojer, Ewa

    2012-02-01

    Transfusion-related acute lung injury (TRALI) is suggested to be a "two hit" event, resulting from priming and activation of pulmonary neutrophils. It is known that neutrophil activation may result from infusion of lysophosphatidylcholines (LysoPCs) accumulated during storage of blood components. The aim of our study was to verify whether the LysoPCs are released into the storage medium of blood components. We measured the LysoPCs concentration in the supernatants from stored apheresis platelet concentrates (PLTs), packed non-leukoreduced red blood cell concentrates (RBCs), leukoreduced red blood cell concentrates (L-RBCs), fresh frozen plasma (FFP) and donor plasma (control). Lipids were separated on high-performance thin-layer chromatography, detected by primulin spray and quantified by photodensitometric scanning. The LysoPCs concentration in donor plasma was similar to that in FFP. During storage the LysoPCs content in PLTs increased almost two-fold as compared to the fresh isolated platelets. In RBCs and L-RBCs the LysoPC level was very low or below detection limit and did not increase throughout the storage period. According to our observations bioactive LysoPCs may be considered a neutrophil-activating factor only following PLT transfusions but not RBCs transfusions.

  4. 探讨脑血管疾病与血脂水平变化之间的关系%To explore the relationship between the changes of cerebralvascular disease and blood lipid level

    Institute of Scientific and Technical Information of China (English)

    曹义仁

    2014-01-01

    Objective to investigate the correlation analysis of changes in lipid levels and cerebral vascular disease , provide a scientiifc basis for actively preventing the occurrence of cerebral blood vessels .Methods between January 2010 - May 2013 in our hospital cerebral hemorrhage , cerebral infarction , 50 cases of patients with total cholesterol collects all (tc), triglyceride (tG), high density lipoprotein (Hdl), low-density lipoprotein (ldl) levels, while healthy people select the same period 50 cases of outpatient physical contrast differences between lipid levels three groups of patients .Results statistical analysis showed that patients with cerebral hemorrhage and cerebral infarction group TC, TG and LDL levels were signiifcantly higher than normal medical group , while Hdl levels were significantly decreased , the difference was significant , with statistical signiifcance (P <0.05). further comparison of cerebral hemorrhage and cerebral infarction patients were found in blood lipid levels , cerebral hemorrhage cerebral high TG levels than the group , and lower HDL levels , signiifcant difference also was statistically signiifcant (P <0.05).Conclusion the occurrence and development of lipid levels and cerebrovascular diseases are closely related, which elevated tc, tG and ldl levels tend to prompt greatly increased risk of cerebrovascular accident , and Hdl as a protective factor for cardiovascular , and its level is reduced and cerebrovascular accident the same happened inseparable .%目的:分析探讨血脂水平变化与脑血管疾病的相关性,为积极预防脑血管的发生提供科学依据。方法选取2010年1月至2013年5月间我院收治脑出血、脑梗死患者各50例,收集所有患者总胆固醇(tc)、甘油三酯(tG)、高密度脂蛋白(Hdl)、低密度脂蛋白(ldl)水平,同时选取同期门诊体检健康人群50例,对比三组患者间血脂水平差异。结果统计分析后发现,脑出血和脑梗死组

  5. 血清性激素、血脂水平与围绝经期症状的相关性%Correlation between serum sex hormones levels, blood lipids levels and perimenopausal symptoms

    Institute of Scientific and Technical Information of China (English)

    秦家云; 刘晓燕; 王丽平; 王艳; 彭丹红

    2013-01-01

    Objective: To research the correlation between serum sex hormones levels, blood lipids levels and perimenopausal symptoms. Methods: The general condition, perimenopausal quality of life, and Kupperman index ( KMI) of 215 women were investigated, then 90 study objects were selected and divided into five groups: control group (20 women) , perimenopausal group (17 women) , early postmenopausal group (21 women) , late postmenopausal group (22 women), and hormone replacement therapy (HRT) group (10 women); the serum levels of estradiol, follicle - stimulating hormone (FSH) , testosterone (T) , total cholesterol (TC) , and triglyceride (TG) were detected and compared, respectively; the perimenopausal symptoms and KMI were compared, and the correlation was analyzed. Results: Compared with control group, the serum levels of estradiol and T in perimenopausal group, early postmenopausal group, and late postmenopausal group decreased significantly (P < 0. 05) . KMIs in perimenopausal group, early postmenopausal group, and late postmenopausal group increased gradually, which were statistically significantly higher than that in control group (P < 0. 05) . There was a negative correlation between estradiol level and KMI (γ = - 0. 334, P = 0. 001) , there was a negative correlation between T level and KMI (γ = -0. 270, P =0. 010) , there was a positive correlation between FSH level and KMI (γ = 0. 504, P = 0. 000 ) ; compared with control group, serum TC and TG levels in perimenopausal group, early postmenopausal group, and late postmenopausal group increased significantly (P < 0. 05 ) , there was a positive correlation between serum TG and KM (γ=0. 294, P = 0. 005) , there was a positive correlation between TC and KMI (γ = 0. 244, P=0. 021) . Conclusion: Serum estradiol and T levels decrease obviously in postmenopausal women, but serum FSH level increases. There is a negative correlation between KMI and serum estradiol, but KMI is positively correlated with serum FSH. Serum

  6. Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial

    DEFF Research Database (Denmark)

    Amarenco, Pierre; Goldstein, Larry B; Messig, Michael

    2009-01-01

    BACKGROUND AND PURPOSE: The relative contributions of on-treatment low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), triglycerides, and blood pressure (BP) control on the risk of recurrent stroke or major cardiovascular events in patients with stroke is not well defined. METHODS: We...

  7. Monitoring Blood Sugar: The Importance of Checking Blood Sugar Levels

    Science.gov (United States)

    ... Feeding Your 1- to 2-Year-Old Monitoring Blood Sugar KidsHealth > For Parents > Monitoring Blood Sugar A ... Other Tests Record Keeping The Importance of Checking Blood Sugar Levels Besides helping to keep blood sugar ...

  8. Relationship of body mass index and blood lipid level with cancer detection on prostate biopsy%体质指数、血脂水平与前列腺穿刺活检阳性间的关系

    Institute of Scientific and Technical Information of China (English)

    张浩宇; 吕广霖; 袁和兴; 魏雪栋; 胡林昆; 张学锋; 侯建全

    2015-01-01

    Objective To investigate the relationship between body mass index (BMI), blood lipid level and cancer de⁃tection in prostate biopsy. Methods A total of 214 patients undergoing a prostate biopsy during 2013.2—2014.8 were re⁃viewed retrospectively. They were divided into prostate cancer and non-cancer groups by biopsy results. The differences of age, prostate-specific antigen (PSA) level, prostate volume (PV), blood lipid level and BMI were analyzed between two groups. Risk factors for cancer detection of biopsy were also analyzed. Results Compared with non-cancer patients, pros⁃tate cancer patients were older, had higher level of PSA and BMI, but smaller PV and lower level of HDL-C ( P<0.05). Lo⁃gistic regression analysis showed that older, higher level of PSA and BMI were risk factors for prostate biopsy positive, but larger PV and higher level of HDL-C were protective factors (P<0.05). Conclusion Comprehensive assessment of BMI and blood lipid levels can provide important reference for prostate cancer screening at early time and establishment of pros⁃tate biopsy scheme, which also provide significant evidence for the prevention, diagnosis and treatment of prostate cancer at early stage for high risk population.%目的:探讨体质指数(BMI)、血脂水平与前列腺穿刺活检阳性之间的关系。方法回顾性分析2013年2月—2014年8月间在我院行前列腺穿刺活检患者214例,根据穿刺病理结果分为前列腺癌组和非癌组,比较2组间年龄、前列腺特异性抗原(PSA)、前列腺体积(PV)、血脂水平、体质指数(BMI)等指标,并分析前列腺穿刺阳性的危险因素。结果前列腺癌组年龄、PSA、BMI高于非癌组,而PV、高密度脂蛋白胆固醇(HDL-C)则低于非癌组(均P<0.05)。Logistic回归分析提示年龄大,PSA、BMI升高是前列腺穿刺活检阳性的危险因素,而PV、HDL-C升高则为保护因素(均P<0.05)。结论综合评估患者BMI

  9. 强化降脂与心脑血管病%Intensive lowering of blood lipid level and cardio-and cerebro-vascular diseases

    Institute of Scientific and Technical Information of China (English)

    仝其广; 胡大一

    2004-01-01

    1994年以来具有里程碑意义的5项大规模临床试验[北欧辛伐他汀生存研究(4S)、西苏格兰冠心病预防研究(WOSCOPS)、胆固醇和冠心病复发事件试验(CARE)、普伐他汀对缺血性心脏病的长期干预(LIPID)和空军/得州冠状动脉粥样硬化预防研究(AFCAPS/TEXCAPS)]充分证明降脂治疗具有能显著减

  10. Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans

    Directory of Open Access Journals (Sweden)

    Bo LI

    Full Text Available Abstract This study investigated the effects of puerarin (PUE on blood lipid and inflammatory factor levels in rats with lower limb arteriosclerosis obliterans (ASO. Sixty rats were randomly divided into control, model, simvastatin, low-PUE, middle-PUE and high-dose PUE group. The animals in later 5 groups were with lower limb ASO, and the later 4 groups were given 1 mg/kg simvastatin and 5, 10 and 20 mg/kg PUE, respectively. The blood lipid and inflammatory factor levels were determined. Results showed that, the serum total cholesterol (TC, triglyceride (TG, low-density lipoprotein cholesterol (LDL-C, interleukin-6 (IL-6, tumor necrosis factor-α (TNF-α and high-sensitivity C-reactive protein (hs-CRP level in model group were significantly increased (P 0.05. PUE can obviously decrease the blood lipid and inflammatory factor levels in rats with lower limb ASO.

  11. Augmentation of blood lipid glycation and lipid oxidation in diabetic patients.

    Science.gov (United States)

    Suzuki, Koichiro; Nakagawa, Kiyotaka; Miyazawa, Teruo

    2014-01-01

    Lipid oxidation plays a role in the pathophysiology of several diseases, including diabetes. Patients with type 2 diabetes show abnormally high plasma levels of phosphatidylcholine hydroperoxide (PCOOH). However, little is known about the biochemical processes that increase plasma PCOOH in diabetes. We hypothesized that "glycated lipid moieties" may form in diabetic plasma and cause oxidative stress resulting in PCOOH formation. To evaluate this hypothesis, liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed to analyze Amadori-glycated phosphatidylethanolamine (Amadori-PE, an early stage Maillard product), as well as the advanced glycation end products (AGE) carboxymethyl-PE (CM-PE) and carboxyethyl-PE (CE-PE). The product ion scan, neutral loss scanning, and multiple reaction monitoring provide useful structural and quantitative information about Amadori-PE, CM-PE, and CE-PE in diabetic plasma and erythrocytes. We found that plasma and erythrocyte Amadori-PE concentrations were significantly higher in diabetic patients (757±377 nM plasma, 2793±989 nM packed cells) than in normal subjects (165±66 nM plasma, 712±52 nM packed cells), and that Amadori-PE concentrations were positively correlated with PCOOH. By contrast, no significant differences were observed in blood AGE-PE concentrations between diabetic patients (CM-PE: 7.7±3.5 nM plasma, 528±83 nM packed cells; CE-PE: 2.5±1.1 nM plasma, 82±24 nM packed cells) and normal subjects (CM-PE: 6.6±3.1 nM plasma, 705±533 nM packed cells; CE-PE: 4.2±1.5 nM plasma, 68±16 nM packed cells). These results suggest that Amadori-PE is more prone to accumulation in the blood with diabetes than CM-PE or CE-PE. This review describes the involvement of blood lipid glycation and lipid oxidation in the development of diabetes.

  12. Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study.

    Science.gov (United States)

    Raitoharju, Emma; Seppälä, Ilkka; Oksala, Niku; Lyytikäinen, Leo-Pekka; Raitakari, Olli; Viikari, Jorma; Ala-Korpela, Mika; Soininen, Pasi; Kangas, Antti J; Waldenberger, Melanie; Klopp, Norman; Illig, Thomas; Leiviskä, Jaana; Loo, Britt-Marie; Hutri-Kähönen, Nina; Kähönen, Mika; Laaksonen, Reijo; Lehtimäki, Terho

    2014-06-25

    Since metabolic syndrome (MetS) is a collection of cardiovascular risk factors involving multiple signaling systems, we related the metabolic abnormalities associated with MetS with circulating microRNA profiles to pinpoint the affected signaling pathways. The blood microRNA profile, genome wide gene expression and serum NMR metabolomics were analyzed from 71 participants of the Young Finns Study. We found nine microRNAs that associated significantly with metabolites connected to MetS. MicroRNA-144-5p concentration correlated with glucose levels, hsa-1207-5p with glycosylated hemoglobin and hsa-miR-484 with metabolites related to insulin resistance. Hsa-miR-625-3p correlated with cholesterol levels, hsa-miR-1237-3p and hsa-miR-331-3p expression with certain fatty acids levels and hsa-miR-129-1-3p, -129-2-3p, and -1288-3p with glycerol levels. The down-regulated targets of miR-1207-5p and -129-2-3p were enriched in PI3K and MAPK pathways and 8 out of the 12 enriched pathways were down-regulated in individuals with MetS. In conclusion microRNAs associated with several aspects of MetS, possibly regulating glucose and lipid metabolism. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  13. Blood pressure and lipid profiles in adolescents with hypertensive parents

    OpenAIRE

    Julia Fitriany; Rafita Ramayati; Supriatmo; Rusdidjas; Oke Rina; Rosmayanti Siregar

    2015-01-01

    Background Adolescent hypertension is a significant health problem of increasing prevalence and causes high morbidity and mortality. It is found primarily in young males, with a familial history of hypertension and/or cardiovascular disease. Examination of lipid profiles has been used to detect the risk of hypertension in adolescents. Objective To compare blood pressure and lipid profiles in adolescents with and without a parental history of hypertension. Methods This cross-sectional ...

  14. Blood pressure and lipid profiles in adolescents with hypertensive parents

    OpenAIRE

    Julia Fitriany; Rafita Ramayati; Supriatmo Supriatmo; Rusdidjas Rusdidjas; Oke Rina; Rosmayanti Siregar

    2016-01-01

    problem of increasing prevalence and causes high morbidity and mortality. It is found primarily in young males, with a familial history of hypertension and/or cardiovascular disease. Examination of lipid profiles has been used to detect the risk of hypertension in adolescents. Objective To compare blood pressure and lipid profiles in adolescents with and without a parental history of hypertension. Methods This cross-sectional study was conducted from January to Februar...

  15. [Exploration of regulating blood lipids metabolism by integrative medicine].

    Science.gov (United States)

    Liu, Shan-shan; Wu, Wei; Qing, Li-jin

    2015-02-01

    Hyperlipidemia is an important risk factor of cardio-/cerebrovascular disease, and reducing lipids has become an important project for itsclinical preventing and treating. Western medicine, with its confirmative efficacy and clear mechanism, has played an irreplaceable role. Along with the development of modern medicine, integrative medicine has gradually become a growing trend in regulating blood lipids metabolism. It not only could make up the insufficient power for Chinese medicine in lowering lipids, but also could reduce adverse reactions and economic costs brought by long-term administration of Western medicine. As a modern practitioner of Chinese medicine, we should keep clear that integrative medicine regulating blood lipids metabolism does not mean a simple combination of traditional Chinese medicine and Western medicine. We should treat it guided by systematic theories. We combine disease identification and syndrome differentiation, guide lipids lowering by integrative medicine including selecting Western drugs for blood lipids lowering, Chinese medical prescriptions for syndrome typing, and effective Chinese herbs based on modern pharmacologies.

  16. Blood lipid metabolites and meat lipid peroxidation responses of ...

    African Journals Online (AJOL)

    Esnart Mukumbo

    2017-06-19

    Jun 19, 2017 ... Fat and protein contents of thigh muscle and abdominal fat weight were ... and the inclusion levels of experimental fats were 2% and 4% in the starter .... 2Vitamin premix provided per kg of diet: vitamin A (retinol), 12000 IU; ...

  17. Effect of high blood lipid level on liver functions among the older hyperlipidemia patients%老年高脂血症患者血脂水平对肝功能的影响

    Institute of Scientific and Technical Information of China (English)

    倪娜; 杨惠元

    2015-01-01

    Objective:To discuss the effect of high blood lipid level on liver functions among the older hyperlipidemia patients, to improve the people's knowledge of hazards from high blood lipid among the older hyperlipidemia patients,to provide help for the clinic solutions.Method:From 2013 health examination of 60 years of age or older,a random sample of 167 cases of hyperlipidemia patients and 100 healthy people were statistically analyzed results of serum alanine aminotransferase.Results: There was statistical significance(P<0.05) that the level of triglycerides(TG),cholesterol(TC)and serum alanine aminotransferase(ALT)of hyperlipidemia patients was higher than the healthy people;there was statistical significance(P<0.05) that the ALT level of the samples both with high TG and TC was higher than either the samples with high TG or TC;there was no statistical significance(P<0.05)in the comparison of samples with high TG and with high TC on their ALT level.Conclusion: Elderly hyperlipidemia and impaired liver function are closely related.%目的:探讨老年人群高脂血症患者血脂水平对肝功能的影响,以提高人们对老年人群高脂血症危害性的认识,为临床有效的干预提供数据。方法:从2013年进行健康体检的60岁以上老年人中,随机抽取167例高脂血症患者和100例健康人群,对其血清谷丙转氨酶结果进行统计学分析。结果:高甘油三酯(TG)组、高胆固醇(TC)组、血清谷丙转氨酶(ALT)均较健康对照组增高,差异有统计学意义(P<0.05);高 TG 合并高 TC 组的 ALT 高于高 TG 组、高TC组,差异有统计学意义(P<0.05);高TG组与高TC组的ALT结果比较差异无统计学意义(P>0.05)。结论:老年人群高脂血症与肝功能受损密切相关。

  18. Effect of x-ray irradiation on lipid peroxide levels in the rat submandibular gland

    Energy Technology Data Exchange (ETDEWEB)

    Nishi, M.; Takashima, H.; Oka, T.; Ohishi, N.; Yagi, K.

    1986-07-01

    We examined the effect of local x-ray irradiation on the changes in the lipid peroxide level in submandibular gland, liver, and blood plasma. Rats five weeks of age received a single low dose of 3 Gy x-ray irradiation to their neck regions. The lipid peroxide level in the submandibular gland was significantly enhanced at seven days after irradiation, as was the level in the blood plasma at two hours, seven and 14 days after irradiation. The lipid peroxide level in the liver decreased, as compared with levels in the controls. There was a slight tendency for acinar cells of the submandibular gland to show pyknosis and anomalous nuclei within three days after irradiation. These results suggest that radiation injury results in an elevation of the lipid peroxides in the submandibular gland, and an increased level in the blood.

  19. Effect of oils sources on blood lipid parameters of commercial laying hens

    Directory of Open Access Journals (Sweden)

    LS Murata

    2003-12-01

    Full Text Available The experiment was carried out to verify if total cholesterol, HDL-cholesterol and triacylglicerol plasma levels are affected when laying hens are fed rations containing different dietary oil sources. One hundred sixty 50 week-old hens, assigned to four treatments with five replicates using 8 hens per replicate were used. The experimental period was of 84 days divided in 3 cycles of 28 days each. In the last day of each cycle, blood samples of 2 hens per replicate were randomly choose and blood samples were collected. On the other hand, blood was also collected at 7 am, 11 am and 3 pm aiming to study the daily changes of these lipids. Blood lipid parameters were not affected by different dietary oil sources (p > 0.05; however, HDL-cholesterol did change during the day, giving evidence that this lipid is indeed involved in the egg yolk formation.

  20. Blood lipid level of patients with lumbar disc herniation:clinical observation of 1681cases%腰椎间盘突出症患者血脂水平的临床观察

    Institute of Scientific and Technical Information of China (English)

    姜丽; 乔延国; 司一民; 何玉宝

    2013-01-01

    目的 研究腰椎间盘突出症患者血脂水平,探讨高脂血水平与腰椎间盘疾病之间的关系.方法 168例经医学影像学和手术确诊的腰椎间盘突出症患者分为2组,一组为81例接受腰椎间盘手术(腰椎间盘组),另一组为87例因其他骨科病接受其他手术(对照组).手术前空腹采集静脉血,测定总胆固醇(TC)和总甘油三酯(TG)水平.结果 两组患者临床特征没有统计学差异,腰椎间盘组总胆固醇(5.41±1.3) mmol/L,甘油三酯(1.65±1.12)mmol/L,均显著高于对照组[分别为(5.22±1.02)mmol/L和(1.53±0.93) mmol/L,P=0.041和P=0.037.结论 血脂水平也许与腰椎间盘疾患发生有关,控制血脂水平可能有助于阻止或者延缓腰椎间盘疾患发展.%Objective To observe serum lipid level of the lumbar disc herniation patients, so as to investigate the relationship between serum lipid levels and lumbar disc disease. Methods 168 patients with lumbar disc herniation confirmed by medical imaging and operation were divided into 2 not significantly different groups demographically: lumbar intervertebral disk operation group (n=81) and control group (n=87, undergoing another operations because of other orthopedic diseases). Fasting blood samples were collected to examine the serum levels of total cholesterol (TC) and triglyceride (TG).Results The TC and TG levels of the lumbar intervertebral disk operation group were (5.41 ± 1.3) mmol/L and(1.65± 1.12) mmol/L respectively, both significantly higher than those of the control group [(5.22±1.02)mmol/L and (1.53±0.93) mmol/L respectively, both P = 0.041 and P =0.037]. Conclusion Serum lipid level may be a risk factor for lumbar intervertebral disk pathology. Control of the serum lipid level may help prevent and/or delay this pathological procedure.

  1. Effect of mitiglinide combined laser photocoagulation on blood glucose, blood lipid and vascular endothelial function in diabetic retinopathy

    Institute of Scientific and Technical Information of China (English)

    Yun-Yan Fan; Gui-Jun Luo

    2016-01-01

    Objective:To observe the effect of mitiglinide combined laser photocoagulation on blood glucose, blood lipid and vascular endothelial function in diabetic retinopathy.Methods:A total of 106 patients with diabetic retinopathy treated in our hospital from January 2014 to January 2015 were selected and assigned into the separate group and combined group. Fifty-three patients in the separate group only received oral mitiginide, while other 53 patients in the combined group received oral mitiglinide and laster photocoagulation surgery. Before and after treatment, the FBG, 2hPBG, HbA1c, TC, TG, HDL-C, LDL-C, ET-1, VEGF, PEDF, ICAM-1, FMD of patients in the two groups were analyzed.Results: After treatment, the blood glucose and blood lipid indexes of patients in the two groups were improved significantly, and there was no statistical difference between the two groups. The ET-1, ICAM-1 and VEGF of patients in the two groups decreased, and the decrease of the combined group was more distinctly. The PEDF and FMD in the two groups all increased, and the combined group changed more obviously. The regression of the blood vessel and the recovery of visual acuity in the combined group were better than the separate group.Conclusions:Mitiglinide combined with laser photocoagulation can effectively improve the level of blood glucose and blood lipid, promote vascular endothelial function and inhibit the formation of retinal neovascularization so as to improve the visual acuity level.

  2. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.

    Directory of Open Access Journals (Sweden)

    Ole A Andreassen

    Full Text Available Epidemiological studies suggest a relationship between blood lipids and immune-mediated diseases, but the nature of these associations is not well understood. We used genome-wide association studies (GWAS to investigate shared single nucleotide polymorphisms (SNPs between blood lipids and immune-mediated diseases. We analyzed data from GWAS (n~200,000 individuals, applying new False Discovery Rate (FDR methods, to investigate genetic overlap between blood lipid levels [triglycerides (TG, low density lipoproteins (LDL, high density lipoproteins (HDL] and a selection of archetypal immune-mediated diseases (Crohn's disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, psoriasis and sarcoidosis. We found significant polygenic pleiotropy between the blood lipids and all the investigated immune-mediated diseases. We discovered several shared risk loci between the immune-mediated diseases and TG (n = 88, LDL (n = 87 and HDL (n = 52. Three-way analyses differentiated the pattern of pleiotropy among the immune-mediated diseases. The new pleiotropic loci increased the number of functional gene network nodes representing blood lipid loci by 40%. Pathway analyses implicated several novel shared mechanisms for immune pathogenesis and lipid biology, including glycosphingolipid synthesis (e.g. FUT2 and intestinal host-microbe interactions (e.g. ATG16L1. We demonstrate a shared genetic basis for blood lipids and immune-mediated diseases independent of environmental factors. Our findings provide novel mechanistic insights into dyslipidemia and immune-mediated diseases and may have implications for therapeutic trials involving lipid-lowering and anti-inflammatory agents.

  3. Thiazolidinediones and blood lipids in type 2 diabetes

    NARCIS (Netherlands)

    van Wijk, JPH; de Koning, EJP; Martens, EP; Rabelink, TJ

    2003-01-01

    We evaluated study population characteristics and treatment effects on blood lipids between studies in which either rosiglitazone (RSG) or pioglitazone (PIO) was investigated in patients with type 2 diabetes. We performed a summary analysis of all published double-blind, placebo-controlled studies w

  4. Thiazolidinediones and blood lipids in type 2 diabetes

    NARCIS (Netherlands)

    van Wijk, JPH; de Koning, EJP; Martens, EP; Rabelink, TJ

    2003-01-01

    We evaluated study population characteristics and treatment effects on blood lipids between studies in which either rosiglitazone (RSG) or pioglitazone (PIO) was investigated in patients with type 2 diabetes. We performed a summary analysis of all published double-blind, placebo-controlled studies

  5. Serum lipid levels in pregnancies complicated by preeclampsia

    Directory of Open Access Journals (Sweden)

    Valmir Jose de Lima

    Full Text Available CONTEXT AND OBJECTIVE: Pre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria. DESIGN AND SETTING: Cross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva. METHODS: This study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL, high-density lipoproteins (HDL and very low density lipoproteins (VLDL were determined. Cases and controls were matched for maternal age, gestational week and body mass index. RESULTS: The VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia. CONCLUSION: Among the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, pre-eclampsia.

  6. The role of cardiorespiratory fitness on plasma lipid levels.

    Science.gov (United States)

    Parto, Parham; Lavie, Carl J; Swift, Damon; Sui, Xuemei

    2015-11-01

    Dyslipidemia is a treatable risk factor for cardiovascular disease. Epidemiological studies have demonstrated the importance of treatment for abnormalities in total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides. Aside from pharmacotherapy, exercise and cardio-respiratory fitness have been shown to have beneficial effects on decreasing cardiovascular disease risk. Even though previous data regarding the benefits of exercise on plasma lipids have been somewhat conflicting, numerous studies have demonstrated that exercise increases HDL-cholesterol and reduces the triglyceride levels. Also, smaller, more atherogenic LDL particles seem to decrease with increases in cardio-respiratory fitness and exercise, and favorable blood lipid profiles seem to persist longer through the adult life span.

  7. Association of plasma lipid levels with atherosclerosis prevalence in psittaciformes.

    Science.gov (United States)

    Beaufrère, Hugues; Vet, Dr Med; Cray, Carolyn; Ammersbach, Mélanie; Tully, Thomas N

    2014-09-01

    The prevalence of atherosclerosis is high in the captive psittacine population and increases with age and female sex. The genera Psittacus, Amazona, and Nymphicus are predisposed to atherosclerosis, whereas the genera Cacatua and Ara are less susceptible. Plasma cholesterol and lipoprotein abnormalities have been suggested as risk factors in the development of atherosclerosis as observed in mammals. To investigate whether the psittacine genera susceptibility to atherosclerosis and the known risk factors of age and sex could be associated with differences in the lipid profile, a retrospective analysis was conducted on blood lipid values from 5625 birds. Prevalence values were obtained from a previously published, large, case-control study and were compared with identified trends in plasma lipid profiles. Genus-specific differences were identified in plasma total cholesterol values that corresponded to observed trends in the prevalence of clinically important atherosclerotic lesions, which were also highly correlated. The effect of age was significant but was mild and may not account for the dramatic increase in atherosclerosis prevalence observed with age. In addition, Quaker parrots ( Myiopsitta monachus ), which were used as experimental models for psittacine atherosclerosis and dyslipidemia, were found to have the highest values in all lipid profile parameters. The results of this study suggest that the differences observed in prevalence among species of the psittacine genera may partly be explained by differences in plasma total cholesterol levels. Results also support the use of Quaker parrots as models for studying atherosclerosis and dyslipidemia.

  8. Plasma lipid levels of rats fed a diet containing pork fat as a source of lipids after splenic surgery.

    Science.gov (United States)

    Dinis, Ana Paula Gonçalves; Marques, Ruy Garcia; Simões, Fernanda Correia; Diestel, Cristina Fajardo; Caetano, Carlos Eduardo Rodrigues; Secchin, Dióscuro José Ferreira; Neto, José Firmino Nogueira; Portela, Margareth Crisóstomo

    2009-06-01

    Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Sixty adult male Wistar rats were divided into six groups of 10 animals each: 1 sham-operated, NB diet; 2 sham-operated, PF diet; 3 total splenectomy (TS), NB diet; 4 TS, PF diet; 5 TS followed by splenic autotransplantation (SA), NB diet; and 6 SA, PF diet. Blood samples were collected at the beginning (D0) and after 12 weeks of the experiment (D + 12) for plasma lipid determination. Morphologic regeneration of splenic tissues was observed, with no differences between groups 5 and 6. When D + 12 plasma lipid levels were compared to D0 levels there were no differences in groups 1, 3, and 5, while in groups 2, 4, and 6 total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triacylglycerols (TAG) increased, and high density lipoprotein (HDL) decreased. At D + 12, groups 2, 4, and 6 had lower HDL than group 3. In conclusion, regardless of the surgical procedure applied to the spleen, an NB diet maintained plasma lipid levels while a diet with PF as source of lipids changed the animals' lipid profile.

  9. Lipid hydroperoxide levels in plant tissues.

    Science.gov (United States)

    Griffiths, G; Leverentz, M; Silkowski, H; Gill, N; Sánchez-Serrano, J J

    2000-08-01

    Hydroperoxides are the primary oxygenated products of polyunsaturated fatty acids and are key intermediates in the octadecanoid signalling pathway in plants. Lipid hydroperoxides (LHPO) were determined spectrophotometrically based on their reaction with an excess of Fe(2+)at low pH in the presence of the dye xylenol orange. Triphenylphosphine-mediated hydroxide formation was used to authenticate the signal generated by the hydroperoxides. The method readily detected lipid peroxidation in Phaseolus: microsomes, senescing potato leaves and in a range of other plant tissues including Phaseolus hypocotyls (26+/-5 nmol g(-1) FW), Alstroemeria floral tissues (sepals 66+/-13 nmol g(-1) FW petals 49+/-6 nmol g(-1) FW), potato leaves (334+/-75 nmol g(-1) FW), broccoli florets (568+/-68 nmol g(-1) FW) and Chlamydomonas cells (602+/-40 nmol g(-1) FW). Relative to the total fatty acid content of the tissues, the % LHPO was within the range of 0.6-1.7% for all tissue types (photosynthetic and non-photosynthetic) and represents the basal oxidation level of membrane fatty acids in plant cells. In order to relate the levels of LHPO to specific signalling pathways, transgenic potato plant lines were used in which lipoxygenase (LOX) (responsible for hydroperoxide biosynthesis) and hydroperoxide lyase (a route of hydroperoxide degradation) activities were largely reduced by an antisense-mediated approach. While the LHPO levels were similar to wild type in the individual LOX antisensed plants, basal LHPO levels, by contrast, were elevated by 38% in transgenic potato leaves antisensed in hydroperoxide lyase, indicating a role for this enzyme in the maintenance of cellular levels of LHPOs.

  10. Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals

    Directory of Open Access Journals (Sweden)

    Blanca Estela Ríos-González

    2014-01-01

    Full Text Available Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP. We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5 rs3135506, APOB rs1042031, FABP2 rs1799883, LDLR rs5925, LIPC rs1800588, LPL rs328, and MTTP rs1800591 with blood pressure and lipid values in Mexican hypertensive (HT patients. A total of 160 HT patients and 160 normotensive individuals were included. Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing. The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic. The alleles FABP2 p.55T, LIPC −514T, and MTTP −493T were associated with elevated systolic BP. Five alleles were associated with lipids. LPL p.474X and FABP2 p.55T were associated with decreased total cholesterol and LDL-C, respectively; APOA5 p.19W with increased HDL-C; APOA5 p.19W and FABP2 p.55T with increased triglycerides; and APOB p.4181K and LDLR c.1959T with decreased triglycerides. The APOB p.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17–2.93; P=0.001 under the dominant model. These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.

  11. 燕麦对高胆固醇血症男性中老年人血脂水平的影响%Effect of Oat on Blood Lipids Level of Middle-aged and Elderly Men with hyPercholesterolemia

    Institute of Scientific and Technical Information of China (English)

    李丽祥; 张坚; 宋鹏坤; 王春荣; 满青青; 孟丽萍

    2011-01-01

    目的:观察食用燕麦对城市患高胆固醇血症男性中、老年人空腹血脂水平的影响.方法:参考《中国成人血脂异常防治指南》中的判断标准,将65名患高胆固醇血症男性中、老年人随机分为2组,分别为燕麦组(33人),每人每日给予100 g即冲即食燕麦片;对照组(32人),每人每日给予100 g普通挂面,试验周期6周.研究开始前和6周时对两组受试者进行基本健康状况问卷调查、人体测量、血生化检测以及膳食调查.结果:燕麦组和对照组的能量、蛋白质、脂肪、碳水化合物摄入量无显著差异,但燕麦组膳食纤维摄入量明显增加,增幅显著大于对照组,P<0.05.6周结束时,燕麦组血清总胆固醇(T℃)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(apoB)水平显著降低(P<0.05);血清TC、LDL-C平均降低幅度分别为7.0%和7.5%.对照组血清胆固醇、脂蛋白及载脂蛋白水平在试验期间未见显著变化.结论:对于我国城市中患高胆固醇血症的男性中、老年人,每日食用一定量的燕麦作为膳食中的粮谷类食物,可有效降低血清TC、LDL-C和apoB水平,减少心脑血管疾病发生的危险.%Objective:To observe the impact of oat intake on the blood lipid level of middle-aged and elderly men with hypercholesterolemia. Methods:By referring to the standards in the Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults, 65 middle-aged and elderly men with hypercholesterolemia was selected and randomly assigned to consume 100 grams of instant oatmeal per day (Oat group,33 subjects) or receive 100 grams common noodle (Control,32 subjects) for 6 weeks. At the beginning and the final time of the intervention, basic health condition questionnaire survey, body measurement, blood biochemical testing and diet survey were undertaken. Results:There is no significant changes in energy, protein, fat, carbohydrate intake between the two groups while dietary

  12. Dietary intake and blood lipid profile in overweight and obese schoolchildren

    Directory of Open Access Journals (Sweden)

    Rinaldi Ana Elisa Madalena

    2012-10-01

    Full Text Available Abstract Background The high blood lipid levels and obesity are one of the main risk factors for cardiovascular diseases, and the atherosclerotic process begins in childhood. Some environmental factors are supposed to be involved in this relationship, such as dietary factors. This study aimed to investigate the relationship between dietary intake and blood lipids levels in overweight and obese schoolchildren. Methods This is a cross-sectional study with 147 overweight and obese schoolchildren in Botucatu city, Brazil. The anthropometric measurements (body weight, height, body mass index, waist circumference and skinfolds, pubertal staging evaluation and biochemical tests were taken in all children. Three 24h-recall were applied in order to estimate the dietary intake and its relationship with blood lipid levels. The Student t test and multiple linear regression analysis were used for statistical analysis. Statistical significance was assessed at the level of 0.05. The data were processed in SAS software (version 9.1.3; SAS Institute. Results At this study, 63% of children were obese (body mass index higher than 95th percentile and 80% showed high body fat percentage. The percentage of children with abnormal total cholesterol and triglycerides was 12% and 10%, respectively, and 28% presented at least one abnormal lipid levels. The average values of anthropometric measurements were higher in children with elevated lipid levels. Total cholesterol levels were positively related to full-fat dairy products and triglycerides levels to saturated fat percentage. Conclusions Saturated fat was positively associated with elevated lipid levels in overweight and obese schoolchildren. These results reinforce the importance of healthy dietary habits since childhood in order to reduce the risks of cardiovascular diseases in adulthood.

  13. Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study.

    Science.gov (United States)

    Geraghty, Aisling A; Alberdi, Goiuri; O'Sullivan, Elizabeth J; O'Brien, Eileen C; Crosbie, Brenda; Twomey, Patrick J; McAuliffe, Fionnuala M

    2016-01-01

    The in-utero environment affects fetal development; it is vital to understand how maternal diet during pregnancy influences childhood body composition. While research indicates that triglycerides in hyperglycaemic women may increase birth weight, little is known about this relationship in euglycemic women. This study examines the relationship between maternal blood lipid status and infant adiposity up to 2 years of age. Data from 331 mother-child pairs from the ROLO longitudinal birth cohort study was analysed. Maternal dietary intakes were recorded and fasting blood lipids, leptin and HOMA were measured in early and late pregnancy and cord blood. Infant anthropometric measurements and skin-fold thicknesses were recorded at birth, 6 months and 2 years. Correlation and regression analyses were used to explore associations between maternal blood lipid status and infant adiposity. All maternal blood lipids increased significantly during pregnancy. Maternal dietary fat intake was positively associated with total cholesterol levels in early pregnancy. Late pregnancy triglycerides were positively associated with birth weight (P = 0.03) while cord blood triglycerides were negatively associated with birth weight (P = 0.01). Cord HDL-C was negatively associated with infant weight at 6 months (P = 0.005). No other maternal blood lipids were associated with infant weight or adiposity up to 2 years of age. Maternal and fetal triglycerides were associated with birth weight and cord HDL-C with weight at 6 months. Thus, maternal lipid concentrations may exert in-utero influences on infant body composition. There may be potential to modulate infant body composition through alteration of maternal diet during pregnancy.

  14. The level of plasma lipid in different blood glucose control stages of type 2 diabetics%血糖控制不同阶段2型糖尿病患者的血脂水平

    Institute of Scientific and Technical Information of China (English)

    季方圆; 逄曙光; 田玉玲

    2015-01-01

    目的:探讨2型糖尿病(T2DM)患者血糖控制不同阶段的血脂水平特点。方法对361例T2DM住院患者(根据既往病史及血糖水平分为血糖控制达标组、血糖控制较差组)及239例健康体检对照组分别测糖化血红蛋白(HbA1c)、血清甘油三酯(TG)、总胆固醇(TCH)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)水平,比较血糖控制达标组、血糖控制较差组及对照组间血脂水平。结果与正常对照组比较,T2DM组TG、TCH、LDL-C水平明显升高,HDL-C水平降低;血糖控制达标组TCH、HDL-C和 LDL-C水平无显著差异( P>0.05);而血糖控制较差组 TCH和 LDL-C水平与正常对照组比较显著升高,HDL-C 水平降低(P<0.05);所有 DM 组的 TG 水平均与正常对照组有显著差异(P<0.05);TG、TCH、HDL-C 和LDL-C均与HbA1c具有平行关系(P<0.05),TG、TCH和LDL-C随HbA1c升高而升高,HDL-C则相反。结论 T2DM 血糖控制情况与血脂水平具有一定的关联性,血糖控制达标有助于TCH和LDL-C的降低及HDL-C的提高,对TG异常亦有所改善。%Objective To investigate the characteristic of plasma lipid in different blood glucose control stages of type 2 diabetics (T2DM).Methods 390T2DMpatientsweredividedintowell-controlledandpoorly-controlledgroupsintermsofmedicalhistoryandblood glucose level,and 210 healthy samples were examined the levels of Hemoglobin A1C(HbA1c),serum triglyceride(TG),total cholesterol (TCH),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C),respectively.Results After elimi-nating other factors on their influence of plasma lipid ,compared with those of normal control group ,the levels of TCH ,HDL-C and LDL-C had no significant differences in the well-controlled group ( P>0.05 ) ;while the levels of TCH and LDL-C were significantly higher and the level of HDL-C was

  15. Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver.

    Science.gov (United States)

    Airanthi, M K Widjaja-Adhi; Sasaki, Naoya; Iwasaki, Sayaka; Baba, Nobuko; Abe, Masayuki; Hosokawa, Masashi; Miyashita, Kazuo

    2011-04-27

    Brown seaweed lipids from Undaria pinnatifida (Wakame), Sargassum horneri (Akamoku), and Cystoseira hakodatensis (Uganomoku) contained several bioactive compounds, namely, fucoxanthin, polyphenols, and omega-3 polyunsaturated fatty acids (PUFA). Fucoxanthin and polyphenol contents of Akamoku and Uganomoku lipids were higher than those of Wakame lipids, while Wakame lipids showed higher total omega-3 PUFA content than Akamoku and Uganomoku lipids. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in liver lipids of KK-A(y) mouse significantly increased by Akamoku and Uganomoku lipid feeding as compared with the control, but not by Wakame lipid feeding. Fucoxanthin has been reported to accelerate the bioconversion of omega-3 PUFA and omega-6 PUFA to DHA and AA, respectively. The higher hepatic DHA and AA level of mice fed Akamoku and Uganomoku lipids would be attributed to the higher content of fucoxanthin of Akamoku and Uganomoku lipids. The lipid hydroperoxide levels of the liver of mice fed brown seaweed lipids were significantly lower than those of control mice, even though total PUFA content was higher in the liver of mice fed brown seaweed lipids. This would be, at least in part, due to the antioxidant activity of fucoxanthin metabolites in the liver.

  16. Association of the blood/air partition coefficient of 1,3-butadiene with blood lipids and albumin.

    Science.gov (United States)

    Lin, Yu-Sheng; Smith, Thomas J; Wypij, David; Kelsey, Karl T; Sacks, Frank M

    2002-02-01

    Pulmonary gas uptake is a function of the blood solubility of a vapor, indicated by the blood/air partition coefficient. We hypothesized that blood lipid compositions are associated with the blood/air partition coefficients of lipophilic toxic vapors such as 1,3-butadiene. Our goal was to investigate cross-sectional and longitudinal relationships of blood triglycerides, total cholesterol, and albumin to the blood/air partition coefficient of butadiene. We collected blood samples from 24 subjects at three time points: a fasting baseline and 2 and 4 hr after drinking a standardized high-fat milk shake (107 g fat, 80 g sugar, and 27 g protein). The blood/air partition coefficient was determined using the closed vial-equilibrium technique. Triglycerides and total cholesterol were analyzed by an enzymatic method, and albumin was analyzed with an immunoassay technique. We used multiple linear regression and general linear models to examine the cross-sectional and longitudinal relationship, respectively. The results showed that the blood/air partition coefficient of butadiene was cross-sectionally associated only with triglycerides at baseline, and longitudinally related to baseline triglycerides, total cholesterol, and the change in triglycerides over time. The blood/air partition coefficient of butadiene increased, on average, by approximately 20% and up to 40% for subjects with borderline higher triglyceride levels after ingestion of a standardized milk shake. In addition, a time factor beyond lipids was also significant in predicting the blood/air partition coefficient of butadiene. This may represent the effects of other unmeasured parameters related to time or time of day on the blood/air partition coefficient of butadiene. Because the blood/air partition coefficient is a major determinant of gas uptake, ingestion of a high fat meal before this type of exposure may significantly increase an individual's absorbed dose, possibly increasing the risk of adverse effects.

  17. Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats

    Institute of Scientific and Technical Information of China (English)

    Rafaat Mohamed Elsanhoty; Mohamed Fawzy Ramadan

    2014-01-01

    Objective:To investigate the effects of different dietary fat and oils (differing in their degree of saturation and unsaturation) on lipid peroxidation in liver and blood of rats. Methods:The study was conducted on 50 albino rats that were randomly divided into 5 groups of 10 animals. The groups were fed on dietary butter (Group I), margarine (Group II), olive oil (Group III), sunflower oil (Group IV) and corn oil (Group V) for 7 weeks. After 12 h of diet removal, livers were excised and blood was collected to measure malondialdehyde (MDA) levels in the supernatant of liver homogenate and in blood. Blood superoxide dismutase activity (SOD), glutathione peroxidase activity (GPx), serum vitamin E and total antioxidant capacity (TAC) levels were also measured to determine the effects of fats and oils on lipid peroxidation. Results: The results indicated that no significant differences were observed in SOD activity, vitamin E and TAC levels between the five groups. However, there was significant decrease of GPx activity in groups IV and V when compared with other groups. The results indicated that feeding corn oil caused significant increases in liver and blood MDA levels as compared with other oils and fats. There were positive correlations between SOD and GPx, vitamin E and TAC as well as between GPx and TAC (r:0.743;P Conclusions:The results demonstrated that feeding oils rich in polyunsaturated fatty acids (PUFA) increases lipid peroxidation significantly and may raise the susceptibility of tissues to free radical oxidative damage.

  18. EFFECTS OF EXERCISE TRAINING ON BLOOD LIPIDS AND LIPOPROTEINS IN CHILDREN AND ADOLESCENTS

    Directory of Open Access Journals (Sweden)

    Kerstin Stoedefalke

    2007-09-01

    Full Text Available The following review aims to describe what is known about the effects of exercise training in children and adolescents on the following blood lipids and lipoproteins: total cholesterol (TC, high density lipoprotein cholesterol (HDL-C, low density lipoprotein cholesterol (LDL-C, and triglycerides (TG. Only studies that described mode, frequency, duration and intensity of the exercise were included in the review. The results of the studies reviewed were equivocal. Clearly the effects of exercise training on the blood lipid and lipoprotein levels of normolipidemic children and adolescents are equivocal. Of the 14 studies reviewed, six observed a positive alteration in the blood lipid and lipoprotein profile, four of the studies observed no alteration in the blood lipid and lipoprotein profile and one study observed a negative effect on HDL-C but an overall improvement in the lipid and lipoprotein profile due to the decrease in the TC/HDL ratio. It appears that methodological problems present in the majority of the exercise training studies limits the ability to make a conclusive, evidence based statement regarding the effect exercise training has on blood lipid levels in normolipidemic children. Most of the research design flaws can be linked to one or more of the following: small numbers of subjects in each study, low or no representation of girls, inclusion of both boys and girls in the subject pool, inclusion of boys and girls at different maturational stages in the subject pool, exercise training regimes that do not adequately control for exercise intensity, exercise training regimes that do not last longer than 8 weeks and exercise training studies that do not have an adequate exercise volume to elicit a change. Ideally, future research should focus on longitudinal studies which examine the effects of exercise training from the primary school years through adulthood

  19. 2010年某大学5256例员工血脂、血糖体检结果分析%Analysis of blood lipids and glucoses levels in 5 256 cases of faculty of certain university in 2010

    Institute of Scientific and Technical Information of China (English)

    冯杨

    2012-01-01

    Objective To understand the health status of university staff and provide basis for medical treatment , diseases prevention and health care . Methods Health examination results of 5 256 cases of in-service teachers were analyzed .Results In total of 5 256 subjects , serum TG level of 972 cases were equal with or more than 1 .70 mmol/L, accounting for 21.66% , serum TC level of 438 cases were equal with or more than 6 .21 μmol/L, accounting for 9 .87% , serum GLU level of 314 cases were equal with or more than 6 .1 μmol/L, accounting for 7 .00% .Blood glucose and lipid levels increased with the increasing of age . And there were statistical difference between different genders , for males were higher than for females .Conclusion Medical treatment, diseases prevention and health care should be further strengthened to improve the staff s health level.%目的 了解高校员工的健康状况,同时为其医疗、预防保健提供依据.方法 对5 256例员工体检结果进行统计分析.结果 5 256例体检者血清测定中,三酰甘油(TG)≥1.70 μmol/L者972例,占21.66%;总胆固醇(TC)≥6.21 μmol/L者438例,占9.87%;血糖(GLU)≥6.1 μmol/L者314例,占7.00%.血糖、血脂水平存在年龄差异,随年龄增长而增高.同时也存在性别差异,男性较高于女性.结论 重视员工的医疗预防保健工作,提高员工的健康水平.

  20. 桂皮提取物对糖尿病大鼠血糖和血脂含量的影响%Effects of cinnamon on blood sugar and lipid levels in diabetic rats

    Institute of Scientific and Technical Information of China (English)

    陈常秀; 李永洙

    2011-01-01

    【Objective】 The study was conducted on the effects of cinnamon on blood sugar and lipid levels in diabetic rats.【Method】 The diabetic rats were induced by intraperitoneal injection of 200 mg/kg alloxan to establish diabetic model.The rats were divided into control group(Ⅰ),model group(Ⅱ),low dose cinnamon treating group(Ⅲ) and high dose cinnamon treating group(Ⅳ).The diabetic rats of group Ⅲ and Ⅳ were orally administered with 100 and 200 mg/(kg·d) cinnamon extract respectively,for 30 days.The rats of group Ⅰ and Ⅱ were orally administered with saline respectively by the same way and the same dose.The daily feed consume,water intake and urine excretion were recorded.The blood sugar,TC,TG,LDL-C,HDL-C level and the body weight were estimated at 0 and 30 d.【Result】 Compared with the rats of group Ⅰ,the body weight of all the diabetic rats of group(Ⅱ,Ⅲ and Ⅳ) decreased significantly(P0.05),and the blood sugar level increased significantly(P0.05) at 0 d.Compared with the rats of groupⅡ,the blood sugar,TC,TG,LDL-C level of the diabetic rats in group Ⅳdecreased significantly(P0.05),the body weight and HDL-C level increased significantly(P0.05) at 30 d.Compared with the rats of group Ⅰ,there were no differences in body weight,blood sugar,TC,TG,LDL-C and HDL-C level of the diabetic rats in group Ⅳ at 30 d(P0.05).【Conclusion】 The cinnamon extract(200 mg/(kg ·d)) decreased the blood sugar,TC,TG and LDL-C level of the diabetic rats induced by alloxan,increased the body weight and enhanced HDL-C level.Enrichment of cinnamon with cinnamate can provide a functional food spice that could potentially benefit human health.%【目的】探讨桂皮提取物对糖尿病大鼠血糖和血脂含量的影响。【方法】给大鼠腹腔注射200mg/kg的四氧嘧啶建立糖尿病模型。试验共分4组:正常对照组(Ⅰ)、糖尿病模型组(Ⅱ)、低剂量桂皮提取

  1. Association between chronic periodontitis and serum lipid levels

    Directory of Open Access Journals (Sweden)

    Pejčić Ana

    2012-01-01

    Full Text Available Background/Aim. Periodontitis is a local inflammatory process mediating destruction of periodontal tissues triggered by bacterial insult. However, this disease is also characterized by systemic inflammatory host responses that may contrbute, in part, to the recently reported increased risk for systemic diseases, including an altered lipid metabolism. On the other hand, many people in the world are affected by hyperlipidemia, which is a known risk faktor for atherosclerosis. The aim of this study was to determine the relationship between periodontal disease and blood lipid levels. Methods. A total of 50 patients with periodontitis included in this study had no documented history of recent acute coronary events. The healthy, non-periodontal subjects (comparison group comprised 25 subjects. All the patients were periodontology examined and completed a medical history. Dental plaque index, probing depth, gingival index bleeding on probing and clinical attechment levels were recorded. Blood samples were taken on admission for measurements of serum total cholesterol, triglycerides, hight density lipoprotein cholesterol (HDL-cholesterol, and low density lipoprotein cholesterol (LDL-cholesterol. Results. The obtained results showed that mean levels of cholesterol (6.09 ± 1.61 mmol/L, triglycerdes (2.19+1.67mmol/l and LDL cholesterol (4.09 ± 1.40 mmol/L in individuals with periodontitis were higer, and levels od HDL (1.43 ± 0.51 mmol/L was lower than those of individuals without periodontitis (4.86 ± 1.37; 1.14 ± 0.71; 3.18 ± 0.64; 1.53 ± 0.32 mmol/L, respectively. Conclusion. This study confirms a significant relationship between periodontal disease, regardless its intensity, and blood lipid levels in the studied population. The results imply that periodontitis may be a risk factor and may contribute to the pathogenesis of atherosclerosis and cardiovascular diseases (CVD. However, future prospective randomized studies have to determine whether

  2. [Effect of phytic acid and its derivatives on blood lipid peroxidation state in vitro].

    Science.gov (United States)

    Martusevich, A K; Sidorova, M V; Mel'nikova, N B; Solov'eva, A G; Peretiagin, S P

    2014-01-01

    We have studied specific features of lipid peroxidation in whole human blood under the action of aqueous solutions of xymedone (19.6 microM), phytic acid (117.9 microM) and its complex (237.6 microM) synthesized in distilled water and isotonic (0.9%) solution of sodium chloride. The estimated parameters included lipid peroxidation (LPO) rate, total antioxidant potential, superoxide dismutase (SOD) level, and malonic dialdehyde (MDA) level in blood plasma and erythrocytes. It was established that the effect of phytic acid on blood samples includes moderate stimulation of total antioxidant activity and SOD activity with predominant prooxidant effect. The phytic acid--xymedone complex synthesized in distilled water exhibits an antioxidant action, while its synthesis in saline solution yields a prooxidant.

  3. Camphor Tree Seed Kernel Oil Reduces Body Fat Deposition and Improves Blood Lipids in Rats.

    Science.gov (United States)

    Fu, Jing; Wang, Baogui; Gong, Deming; Zeng, Cheng; Jiang, Yihao; Zeng, Zheling

    2015-08-01

    The total and positional fatty acid composition in camphor tree (Cinnamomum camphora) seed kernel oil (CKO) were analyzed, and for the first time, the effect of CKO on body fat deposition and blood lipids in rats was studied. The major fatty acids in CKO were determined to be decanoic acid (C10:0, 51.49%) and dodecanoic acid (C12:0, 40.08%), and uniformly distributed at Sn-1, 3, and Sn-2 positions in triglyceride (TG). Rats were randomly divided into control, CKO, lard, and soybean oil groups. At the end of the experiment, levels of blood lipids and the fats of abdomen in the rats were measured. The main organ were weighted and used for the histological examination. The results showed that body weight and fat deposition in CKO group were significantly lower than the lard and soybean groups. Moderate consumption of CKO was found to improve the levels of blood TG and low density lipoprotein cholesterol.

  4. 冠心病心血瘀阻证患者不同中医体质类型与血脂水平的关系%Relationship Between Different Body Constitutions of CHD Patients with Blood Stasis Syndrome and Their Blood Lipid Levels

    Institute of Scientific and Technical Information of China (English)

    田松; 祁若可; 程月招; 何茜; 武小雪

    2014-01-01

    Objective To study the distribution of body constitutions of CHD patients with blood stasis syndrome;To explore the relationship between different body constitutions and their blood lipid levels.Methods WANG’s Constitutional Classification was used to diagnose body constitutions of 600 CHD patients with blood stasis syndrome, and analyze the relationship between the different body constitutions and triglyceride (TG) level, low density cholesterol (LDL-C) level, high density cholesterol (HDL-C) level.Results The four most common body constitutions of CHD patients with blood stasis syndrome in Taiyuan area were the constitutions of blood stasis, yang deficiency, qi deficiency and yin deficiency. The TG levels of the four body constitutions were higher than those of healthy people (P0.05).Conclusion There is a certain difference among the blood lipid levels in different body constitutions of CHD patients with blood stasis syndrome, and the patients of blood stasis syndrome with high LDL-C level are more dangerous than patients with other body costitutions.%目的:观察冠心病心血瘀阻证患者的主要体质类型,探讨不同体质类型与血脂水平的关系。方法运用王氏体质分类法对600例冠心病心血瘀阻证患者进行体质分型,分析主要体质类型与三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平的关系。结果冠心病心血瘀阻证患者排名前4位的体质类型分别为瘀血质、阳虚质、气虚质、阴虚质。4类体质的TG水平均高于健康组(P<0.01),各体质间TG水平无明显差异(P>0.05);瘀血质LDL-C水平高于其他体质及健康组(P<0.01);不同体质类型HDL-C水平无明显差异,与健康组比较差异无统计学意义(P>0.05)。结论冠心病心血瘀阻证不同体质类型间的血脂水平具有差异性,瘀血质LDL-C危险性高于其他体质。

  5. Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples.

    Science.gov (United States)

    Kim, Tae Hyung; Bang, Du Yeon; Lim, Hyun Jung; Won, A Jin; Ahn, Mee Young; Patra, Nabanita; Chung, Ki Kyung; Kwack, Seung Jun; Park, Kui Lea; Han, Soon Young; Choi, Wahn Soo; Han, Jung Yeol; Lee, Byung Mu; Oh, Jeong-Eun; Yoon, Jeong-Hyun; Lee, Jaewon; Kim, Hyung Sik

    2012-03-01

    Polybrominated diphenyl ethers (PBDEs), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. The goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of PBDEs in South Korean. We assessed PBDE levels in paired samples of umbilical cord blood, maternal blood, and breast milk. The levels of seven PBDE congeners were measured in 21 paired samples collected from the Cheil Woman's Hospital (Seoul, Korea) in 2008. We also measured thyroid hormones levels in maternal and cord blood to assess the association between PBDEs exposure and thyroid hormone levels. However, there was no correlation between serum thyroxin (T4) and total PBDEs concentrations. The total PBDEs concentrations in the umbilical cord blood, maternal blood, and breast milk were 10.7±5.1 ng g(-1) lipid, 7.7±4.2 ng g(-1) lipid, and 3.0±1.8 ng g(-1) lipid, respectively. The ranges of total PBDE concentrations observed were 2.28-30.94 ng g(-1) lipid in umbilical cord blood, 1.8-17.66 ng g(-1) lipid in maternal blood, and 1.08-8.66 ng g(-1) lipid in breast milk. BDE-47 (45-73% of total PBDEs) was observed to be present dominantly in all samples, followed by BDE-153. A strong correlation was found for major BDE-congeners between breast milk and cord blood or maternal blood and cord blood samples. The measurement of PBDEs concentrations in maternal blood or breast milk may help to determine the concentration of PBDEs in infant.

  6. Serum Lipids and Lipoproteins Levels and Selected Trace Metals In ...

    African Journals Online (AJOL)

    Serum Lipids and Lipoproteins Levels and Selected Trace Metals In Newly ... This study aim to determine the serum levels of trace metals and correlate same with serum levels of lipoproteins (an established marker of HBP) in ... Article Metrics.

  7. The Mixture of Yogurt and Strawberry Juice to Repair Blood Lipid Profile

    Directory of Open Access Journals (Sweden)

    Rince Alfia Fadri

    2014-01-01

    Full Text Available There are so many ways to do in reducing cholesterol concentration in blood. Yogurt and strawberry juice have ability  to repair blood lipid profile at hypercholesterolemia. Research and lactobacillus development potention as the cholesterol killing probiotic that to be mixed with strawberry juice is necessary to do to support community health. The purpose of this reasearch was measuring the mixture of yogurt and strawberry juice effectiveness to repair blood lipid profile.  The design of this research that to be used was experimental by pretest and posted randomized control design progam. The sample of this research was thirty white mice (Rattus Norvegicus. Cholesterol Total, HDL and LDL to be analyzed by WI-M-KK2 BLK-SB methode (Clinical Chemstry Auto Analyzer using tool Selectra E Auto Analyzer. The data was analyzed by Anova test, continued by LSD test using computer program . The result after giving mixture of yogurt and strawberry juice with the dosage 2ml and 3ml per day could obviously reduce LDL Level (p<0,05, Cholesterol Total (p<0,05 and to increase HDL Level (p>0,05. The differentiation in dosis giving showed unmeaning reduction result (p>0,05. Conclusion, the mixture of yogurt and strawberry juice could repair blood lipid profile, where it’s proved to reduce drastically choleterol Total Level, LDL in 30 days.

  8. Effects of protein intake on blood pressure, insulin sensitivity and blood lipids in children: a systematic review.

    Science.gov (United States)

    Voortman, Trudy; Vitezova, Anna; Bramer, Wichor M; Ars, Charlotte L; Bautista, Paula K; Buitrago-Lopez, Adriana; Felix, Janine F; Leermakers, Elisabeth T M; Sajjad, Ayesha; Sedaghat, Sanaz; Tharner, Anne; Franco, Oscar H; van den Hooven, Edith H

    2015-02-14

    High protein intake in early childhood is associated with obesity, suggesting possible adverse effects on other cardiometabolic outcomes. However, studies in adults have suggested beneficial effects of protein intake on blood pressure (BP) and lipid profile. Whether dietary protein intake is associated with cardiovascular and metabolic health in children is unclear. Therefore, we aimed to systematically review the evidence on the associations of protein intake with BP, insulin sensitivity and blood lipids in children. We searched the databases Medline, Embase, Cochrane Central and PubMed for interventional and observational studies in healthy children up to the age of 18 years, in which associations of total, animal and/or vegetable protein intake with one or more of the following outcomes were reported: BP; measures of insulin sensitivity; cholesterol levels; or TAG levels. In the search, we identified 6636 abstracts, of which fifty-six studies met all selection criteria. In general, the quality of the included studies was low. Most studies were cross-sectional, and many did not control for potential confounders. No overall associations were observed between protein intake and insulin sensitivity or blood lipids. A few studies suggested an inverse association between dietary protein intake and BP, but evidence was inconclusive. Only four studies examined the effects of vegetable or animal protein intake, but with inconsistent results. In conclusion, the literature, to date provides insufficient evidence for effects of protein intake on BP, insulin sensitivity or blood lipids in children. Future studies could be improved by adequately adjusting for key confounders such as energy intake and obesity.

  9. 对羟基苯乙酮对正常大鼠胆汁分泌及高脂血症的影响%Effects of p-hydroxyacetophenone on bile secretion and blood lipid levels in rats

    Institute of Scientific and Technical Information of China (English)

    邓轶方; 于鹏霞; 黄晓玲; 贺兴冬; 殷明; 刘珉宇

    2016-01-01

    目的:研究对羟基苯乙酮(PHA)促胆汁分泌和降血脂作用以及初步作用机制。方法正常SD大鼠行胆管插管术,收集给药前30 min和给药后3 h分泌的胆汁,测定胆汁单位时间内的分泌量和胆汁成分;建立大鼠高血脂模型,观察PHA的降胆固醇作用;制备正常大鼠可溶性HMG唱CoA还原酶,测定PHA对 HMG唱CoA还原酶活性的影响;对大鼠高胆固醇血症实验中得到的动物肝脏样本,进行Real唱time PCR试验。结果 PHA可以增加实验大鼠胆汁和胆汁酸的分泌量;同时能够显著降低高胆固醇血症大鼠的胆固醇水平,具有调血脂作用;初步的作用机制研究显示,PHA抑制 HMG唱CoA还原酶活性的作用较弱,但可以促进影响胆汁酸外排及胆固醇转化的AQP8、CYP7A1、OATP、NTCP等基因的转录。结论 PHA作为茵陈中一种有效的单体化合物,可用于促进胆汁分泌、调节血脂代谢药物的研发。%Objective To study the effects and mechanism of p-hydroxyacetophenone (PHA ) on bile secretion ,choles-terol metabolism and blood lipids .Methods Cystic duct cannula was cannulated and bile were collected in SD rats .PHA was administrated in the high cholesterol rats .The activity of HMG-CoA reductase was determined by spectrophotometry in reac-tion system .Samples of liver were obtained in experiment hypercholesterolemia rats and Real-time PCR test was conducted for AQP8 ,CYP7A1 ,OATP and NTCP .Results Secretion of bile were increased ,cholesterol in bile were reduced and secretion of total bile acid were increased in rats by PHA .The level of serum cholesterol in hyperglycemia rat model was reduced signifi-cantly and inhibitory ability had been limited in the activity of HMG-CoA reeducates by PHA ,but the gene transcription inclu-ding AQP8 ,CYP7A1 ,OATP ,and NTCP were promoted ,which are related to function of excretion of biliary acid and trans-formation of cholesterol .Conclusion These

  10. 甘肃省裕固族地区中老年居民血脂水平的流行病学调查%Related analysis on the level of blood lipid in the mid-aged and elderly people in Yugu minority area of Gansu province

    Institute of Scientific and Technical Information of China (English)

    兰咏梅; 韩涛; 金龙; 王小恒; 裴淑艳

    2011-01-01

    目的 观察甘肃省裕固族地区中老年居民血脂水平及血脂异常状况,为该地区血脂异常的防治工作提供科学依据.方法 采用整群随机抽样方法,对长期居住在甘肃肃南裕固族自治县的511名中老年居民进行现况调查,检测血浆TC、TG、LDL-C、HDL-C水平.结果 ①高TC、高TG、高LDL-C血症为该地区人群血脂异常的主要类型,异常发生率分别为42.86%、60.86%、53.62%.②血脂异常与年龄、性别有关.60岁以上女性TC及LDL-C显著高于男性(P<0.05).③裕固族中老年TC、LDL-C水平高于汉族,有显著性差异(P<0.05).④高血压组TC、LDL-C水平与血压正常组有显著性差异(P<0.01,P<0.05),超重肥胖组TC、TG、LDL-C水平均高于正常体重组(P<0.05).结论 该地区中老年居民为血脂异常的高发人群,血脂异常与超重肥胖、腹型肥胖、高血压具有显著相关性.%Objective To study the level of blood lipid and the prevalence rate of abnormal blood lipid level in the mid-aged and elderly people in Yugu minority area of Gansu province, so as to provide evidence to prevent and cure abnormal blood lipid in the future.Methods Cross-sectional investigation in 511 mid-aged and elderly people in Yugu minority autonomous region were carried out by cluster random sampling.The plasma levels of total cholesterol (TC), triglyceride(TG), low-density li poprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C) were determined.Results ( 1 ) High TC, high TG and high LDL-C were the main types of abnormal blood lipid in this area, the prevalence rates were 42.86%, 60.86% and 53.62% respectively.(2)The prevalence rate of abnormal blood lipid was related with age and gender.( 3 ) The levels of blood lipid in the mid-aged and elderly people of Yugu minority were significanfiy higher than those of Han nationality ( P < 0.05 ).(4) The plasma levels of TC and LDL-C in hypertension group were significandy greater than

  11. Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids.

    Science.gov (United States)

    Yamashita, Shinji; Kiko, Takehiro; Fujiwara, Hironori; Hashimoto, Michio; Nakagawa, Kiyotaka; Kinoshita, Mikio; Furukawa, Katsutoshi; Arai, Hiroyuki; Miyazawa, Teruo

    2016-01-01

    Aside from accumulation of amyloid-β (Aβ) peptide in the brain, Alzheimer's disease (AD) has been reported as being associated with peroxidation of major phospholipids (e.g., phosphatidylcholine (PtdCho)) and degradation of antioxidative phospholipids (e.g., ethanolamine plasmalogen (PlsEtn)). In addition to its presence in the brain, Aβ is also found in blood; however, there is still little information about the levels of PtdCho hydroperoxide (PCOOH) and PlsEtn in the blood of patients with AD. In this study, by assuming a possible interaction among Aβ, PCOOH, and PlsEtn in blood circulation, we evaluated the levels of these molecules and correlations in blood samples that had been obtained from our former AD study for PCOOH measurement (Kiko et al., J Alzheimers Dis28, 593-600, 2012). We found that when compared to controls, plasma from patients with AD showed lower concentrations of PlsEtn species, especially PlsEtn bearing the docosahexaenoic acid (DHA) moiety. In addition, lower PlsEtn and higher PCOOH levels were observed in red blood cells (RBCs) of patients with AD. In both AD and control blood samples, RBC PCOOH levels tended to correlate with plasma levels of Aβ40, and each PlsEtn species showed different correlations with plasma Aβ. These results, together with in vitro data suggesting Aβ aggregation due to a decrease in levels of PlsEtn having DHA, led us to deduce that Aβ is involved in alterations in levels of PCOOH and PlsEtn species observed in the blood of patients with AD.

  12. 多沙唑嗪对兔食饵性高脂血症作用%Effects of doxazosin on blood lipid levels in cholesterol-fed rabbits models

    Institute of Scientific and Technical Information of China (English)

    赵静惠; 杨梅; 闫胜敏; 段保湘

    2012-01-01

    目的 观察多沙唑嗪(DOX)对动脉粥样硬化兔模型血脂水平的影响.方法 健康雄性新西兰兔随机分为普通饮食组、高脂饮食组、DOX治疗组,每组10只.普通饮食组予普通饲料喂养,其余2组予高脂饲料.喂养4周后,DOX治疗组每日定时予DOX 1 ml/kg腹腔注射,连续给药9周.分别于实验开始时(0周、4周、7周、10周、13周)抽取空腹血标本,检测各组血清总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C).结果 高脂饮食组兔血清TC第4周末(28.63±7.65)mmol/L,第13周末(40.83±3.90)mmol/L,血清LDL-C第4周末(16.21±9.59)mmol/L,第13周末(28.46±3.81)mmol/L,随高脂饲养的时间延长,血清TC、LDL-C水平进一步显著升高(P<0.05或0.05).结论 DOX对高血脂兔的血清TC、LDL-C 紊乱具有轻度的改善作用.%Objective To observe the effect of doxazosin ( DOX ) on blood lipid levels in rats with atherosclerosis. Methods New Zealand male rabbits were randomly divided into 3 groups:normal diet group,high fat diet group,DOX treatment group,with 10 rabbits in each group. The rabbits in normal diet group were fed with normal feed, however, the rabbits in the latter two groups were fed with high fat diet. After 4-week feeding, the rabbits in DOX treatment group were intraperitoneally injected with DOX lmg/kg,once a day for 9 weeks. The serum levels of TC,TG,LDL-C were detected at 0,4,7,10,13 weeks for the three groups. Results The levels of TC in high fat diet group were ( 28. 63 ±7. 65 )mmol/L at the end of 4 weeks,( 40. 83 ±3. 90 )mmol/L at the end of 13 weeks,and the levels of LDL-C were( 16.21 ±9.59 )mmol/L at the end of 4 weeks,( 28. 46 ±3. 81 )mmol/L at the end of 13 weeks respectively, with the time prolongation of high fat diet feeding,the levels of TC,LDL-C were increased further ( P 0. 05 ). Conclusion DOX can improve the disorder of LDL-C and TC mildly in the rabbits with hyperlipemia.

  13. 吸烟对2型糖尿病男性患者血脂水平的影响%Effect of smoking on the blood lipid level of male patients with type 2 diabetes

    Institute of Scientific and Technical Information of China (English)

    刘佳; 王佑民; 冯双双

    2015-01-01

    目的:探讨吸烟对2型糖尿病男性患者三酰甘油( TG)、胆固醇( TC)、高密度脂蛋白( HDL-C)、低密度脂蛋白( LDL-C)的影响。方法选取2型糖尿病男性患者144例,按吸烟情况分为不吸烟组(从不吸烟)、戒烟组(戒烟半年以上)、少量吸烟组(≤20支/d)、大量吸烟组(>20支/d),采用现场调查结合病例对照研究的方法,问卷调查表的形式,询问患者年龄、糖尿病病程、运动、饮食、吸烟、调脂药的应用等情况;测量血压、身高、体重、腰围、臀围,计算体重指数( BMI)、腰臀比( WHR)、体脂分数等指标。实验室检测TG、TC、HDL-C、LDL-C等,比较各组间血脂、载脂蛋白水平的差异;采用协方差分析校正其他影响因素,比较各组血脂的差异情况;逐步回归及偏相关分析,了解吸烟对血脂影响的相关性及影响程度。结果①不吸烟组与大量吸烟组比较, TG显著降低( P 20 per day) smokers. All of them were investigated about the age, diabetes pathogenesis, exercise, diet, smoking, lipid-lowering drugs used and checked with TG, TC, HDL-C, LDL-C and so on. The difference of TG, TC, HDL-C, LDL-C among these four groups was compared by the methods of covariance analysis, regression analysis and partial correlation to evalu-ate the relationships of smoking with blood lipid. Results TG of heavy smokers was higher than the non-smokers and HDL-C was lower after correcting the effects of other possibly relative factors(P<0. 05). HDL-C of the former smokers was higher than smokers and TG was lower than heavy smokers(P<0. 05). Smoking was an independent risk factor for HDL-C ( P<0. 05 ,β= -0. 213 ) , and there was a significantly negative relationship between daily cigarette consumption and HDL-C ( r= -0. 223 , P<0. 05 ) . Conclusion Smoking is an important risk factor for the diabetic male patients’ metabolism of the TG and HDL-C,independent of age, body mass index, blood pres

  14. Assessment of glycaemic, lipid and blood pressure control among ...

    African Journals Online (AJOL)

    Diabetes mellitus (DM) is a metabolic disorder primarily characterized by elevated blood glucose levels and microvascular andmacrovascular complications. ... are needed to reduce the likelihood of development of macrovascular disease.

  15. Lipid emulsion solution: A novel cause of hemolysis in serum and plasma blood samples.

    Science.gov (United States)

    Jaben, Elizabeth A; Koch, Christopher D; Karon, Brad S

    2011-02-01

    After several hemolyzed blood samples were received in the laboratory, we investigated lipid emulsion/TPN as a novel cause of hemolysis. Whole blood was spiked with lipid emulsion and TPN. Hemolysis was proportional to the amount of lipid emulsion present in whole blood, with less hemolysis occurring in blood gas syringes compared to vacutainer tubes. Collection of specimens in blood gas syringes may prevent hemolysis in patients on lipid emulsion. Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  16. Association between omega-3 index and blood lipids in older Australians.

    Science.gov (United States)

    Ferguson, Jessica J A; Veysey, Martin; Lucock, Mark; Niblett, Suzanne; King, Katrina; MacDonald-Wicks, Lesley; Garg, Manohar L

    2016-01-01

    Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) has been shown to modulate blood lipid profiles and reduce the risk of developing CVD. However, studies relating objective measures of long-term dietary n-3 PUFA intake and circulating lipid levels in older adults are limited. Thus, we aimed to determine whether there is an association between erythrocyte n-3 PUFA status (omega-3 index, O3I) and blood lipid profiles in older adults. A sample of adults aged 65-95 years who participated in the Retirement Health and Lifestyle Study was evaluated. Outcome measures included O3I (% eicosapentaenoic acid+% docosahexaenoic acid) and fasting blood lipid profiles [total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride (TG)]. Two hundred and seventy-six subjects were included in the analyses. The mean±SD age was 77.6±7.4 years, and 40.9% were males. O3I was significantly higher in females compared to males. O3I was inversely associated with plasma TG (Plipid profiles in older Australians. Our findings support the development and implementation of age-specific dietary strategies to reduce the risk of CVD via improving the O3I.

  17. Blood antioxidant status and erythrocyte lipid peroxidation following distance running.

    Science.gov (United States)

    Duthie, G G; Robertson, J D; Maughan, R J; Morrice, P C

    1990-10-01

    The relationship between prolonged exercise, oxidative stress, and the protective capacity of the antioxidant defense system has been determined. Venous blood samples were removed from seven trained athletes before and up to 120 h after completion of a half-marathon for measurements of blood antioxidants, antioxidant enzymes, and indices of lipid peroxidation. Plasma creatine kinase (CK) activity, an index of muscle damage, increased (P less than 0.05) to a maximum 24 h after the race but this was not accompanied by changes in conjugated dienes and thiobarbituric acid reactive substances (TBARS), which are indices of lipid peroxidation. An increase (P less than 0.05) in plasma cholesterol concentration (4%) immediately after the race was similar to the change in plasma volume (6%). However, transient increases (P less than 0.05) immediately postrace in the plasma concentrations of uric acid (24%), vitamin A (18%), and vitamin C (34%) were only partly accounted for by the fluid shifts. The immediate postrace increases in alpha- and gamma-tocopherol did not attain statistical significance. Erythrocyte antioxidant enzyme activities were unaffected by the exercise but the alpha- and gamma-tocopherol concentrations progressively increased (P less than 0.001 and P less than 0.05, respectively) up to 48 h postrace. Paradoxically, 24 h after the race erythrocyte susceptibility to in vitro peroxidation was markedly elevated (P less than 0.01). This enhanced susceptibility to peroxidation was maintained even at 120 h postrace and did not correspond to changes in the age of the red cell population. A decrease (P less than 0.001) in total erythrocyte glutathione immediately after the half-marathon was mainly due to a reduction in the reduced form (GSH). The results show that when trained athletes run a comparatively short distance sufficient to result in some degree of muscle damage but which is insufficient to cause elevations in plasma indices of lipid peroxidation

  18. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease.

    Science.gov (United States)

    Bordia, A; Verma, S K; Srivastava, K C

    1997-05-01

    In a placebo-controlled study the effect of ginger and fenugreek was examined on blood lipids, blood sugar, platelet aggregation, fibrinogen and fibrinolytic activity. The subjects included in this study were healthy individuals, patients with coronary artery disease (CAD), and patients with non-insulin-dependent diabetes mellitus (NIDDM) who either had CAD or were without CAD. In patients with CAD powdered ginger administered in a dose of 4 g daily for 3 months did not affect ADP- and epinephrine-induced platelet aggregation. Also, no change in the fibrinolytic activity and fibrinogen level was observed. However, a single dose of 10 g powdered ginger administered to CAD patients produced a significant reduction in platelet aggregation induced by the two agonists. Ginger did not affect the blood lipids and blood sugar. Fenugreek given in a dose of 2.5 g twice daily for 3 months to healthy individuals did not affect the blood lipids and blood sugar (fasting and post prandial). However, administered in the same daily dose for the same duration to CAD patients also with NIDDM, fenugreek decreased significantly the blood lipids (total cholesterol and triglycerides) without affecting the HDL-c. When administered in the same daily dose to NIDDM (non-CAD) patients (mild cases), fenugreek reduced significantly the blood sugar (fasting and post prandial). In severe NIDDM cases, blood sugar (both fasting and post prandial) was only slightly reduced. The changes were not significant. Fenugreek administration did not affect platelet aggregation, fibrinolytic activity and fibrinogen.

  19. Dynamical Modes of Deformed Red Blood Cells and Lipid Vesicles in Flows

    Science.gov (United States)

    Noguchi, H.

    Red blood cells and lipid vesicles exhibit rich behaivor in flows.Their dynamics were studied using a particle-based hydrodynamic simulation method, multi-particle collision dynamics. Rupture of lipid vesicles in simple shear flow was simulated by meshless membrane model. Several shape transitions of lipid vesicles and red blood cells are induced by flows. Transition of a lipid vesicle from budded to prolate shapes with increasing shear rate and ordered alignments of deformed elastic vesicles in high density are presented.

  20. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice.

    NARCIS (Netherlands)

    n den Hil, E.F. Hoek-va; Keijer, J.; Bunschoten, A.; Vervoort, J.J.; Stankova, B.; Bekkenkamp, M.; Herreman, L.; Venema, D.; Hollman, P.C.H.; Tvrzicka, E.; Rietjens, I.M.C.M.; Schothorst, E.M. van

    2013-01-01

    Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and (1)

  1. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

    NARCIS (Netherlands)

    Hoek-van den Hil, E.F.; Keijer, J.; Bunschoten, A.; Vervoort, Jacques; Stankova, B.; Bekkenkamp-Grovestein, M.; Herreman, L.; Venema, D.P.; Hollman, P.C.H.; Tvrzicka, E.; Rietjens, I.; Schothorst, van E.M.

    2013-01-01

    Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and 1H

  2. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice.

    NARCIS (Netherlands)

    n den Hil, E.F. Hoek-va; Keijer, J.; Bunschoten, A.; Vervoort, J.J.; Stankova, B.; Bekkenkamp, M.; Herreman, L.; Venema, D.; Hollman, P.C.H.; Tvrzicka, E.; Rietjens, I.M.C.M.; Schothorst, E.M. van

    2013-01-01

    Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and (1)

  3. Inverse correlation among organochlorine pesticide levels to total lipid serum contents: a preliminary study in Veracruz, México.

    Science.gov (United States)

    Caba, Mario; Meza, Enrique; Waliszewski, Stefan M; Martínez-Valenzuela, Carmen

    2015-07-01

    Organochlorine pesticides, due to their hydrophobic nature and persistence, accumulate in tissues rich in lipids, which had been used as a biomarker for environmental pollution. In humans, organochlorine pesticides are continuously circulating and equilibrating among body compartments. The objective of the study was to evaluate the concentrations of organochlorine pesticides in blood serum and compare their levels to the total lipid contents in Veracruz, México inhabitants. Our hypothesis is that concentrations of organochlorine pesticides will increase just as lipid concentrations. Levels of organochlorine pesticides were divided in ascending tertils according to their total lipid content. The linear trend model applied surprisingly reveals that the average level of all organochlorine pesticides decreases as the lipid concentration increases. From one tertil to the next β-HCH, it shows a decrease of -3.19 mg kg(-1) on lipid basis, pp.'DDE levels decrease by -3.70 mg kg(-1) on lipid basis and pp.'DDT levels decrease -1.13 mg kg(-1) on lipid basis. We conclude that the levels and the orderly sequence of organochlorine pesticide distributions in the blood serum maintain an inverse relationship to total lipid blood serum concentrations.

  4. [Disturbances of blood lipid content after acute disorders of brain blood flow].

    Science.gov (United States)

    Ivanova, N E; Lebedev, I A; Akinina, S A; Anishchenko, L I; Koltsov, V V; Beliavskiĭ, A R; Sokolova, A A; Iakovlev, S V

    2011-01-01

    The parameters of blood lipid spectrum have been analyzed in 421 patients who survived cerebral stroke and transitory ischemic attacks in 2004-2008. The study included people of Khanty-Mansiysk and Khanty-Mansi autonomous okrug and watchmen. The statistical analysis did not reveal differences between mean concentrations of total cholesterol, high and low density lipoproteins and triglycerides in the settled population and in watchmen. Mean values of all parameters, with the exception of high-density lipoprotein, were higher compared to normative values. The highest frequency of deviations was found for low-density lipoproteins (63.5% of cases). The highest concentrations of total cholesterol and low-density proteins were seen in patients after transitory ischemic attacks regardless of their sex. The comparison of blood lipid spectrum parameters in different age groups revealed significant differences only for total cholesterol.

  5. Blood-lipid levels of 20041 kindergarten children aged 3 to 6 in Tianjin%天津市20041名3~6岁入托儿童血脂水平分析

    Institute of Scientific and Technical Information of China (English)

    乔毅娟; 王华; 刘恩庆; 张晓燕; 潘蕾; 付伯津; 王萍; 田祯

    2012-01-01

    Objective To understand the level of blood-lipid and prevalence of dyslipidcmia of children aged 3 to 6 in Tianjin,so as to provide evidence for large-scale blood screening strategy and to develop intervention of dyslipidemia and cardiovascular in children.Methods 20 041 children aged 3 to 6 from 48 kindergartens were involved in this study,in Tianjin.Peripheral blood was collected from right leech-finger of these children,after fatless breakfast.Total cholesterol (TC) and triglyceride (TG) of plasma were tested using Toshiba 120 Automatic Biochemical Analyzer.Results The average levels of TC and TG were (4.17 ±0.69)mmol/L and (0.86±0.44) mmol/L in these children.11.4% of the children had either TC or TG dyslipidemia,with 7.1% had only TC dyslipidemia,4.9% had only TG dyslipidemia,and 0.6% of them had both TC and TG dyslipidemia.The prevalence of TC dyslipidemia was significantly higher among girls than boys.The prevalence rates of TC dyslipidemia and TG dyslipidcmia were different among age groups,but with no significant changes among age groups.The prevalence of TG dyslipidemia was significantly different,with obese children higher than those with normal or overweight children.Different residential areas seemed to be related to the difference on the prevalence of dyslipidemia.Prevalence of TC dyslipidemia was higher in urban than in rural areas.Prevalence of TG dyslipidemia was higher in rural than urban areas.Conclusion The prevalence of dyslipidemia for children aged 3 to 6 was high in Tianjin,and showed differences among genders,age groups and residential regions.Screening and intervention programs on dyslipidemia should be undertaken routinely in children,in order to prevent adult atherosclerosis and coronary heart disease.%目的 了解天津市3~6岁儿童血脂水平和血脂异常检出率.方法 采集天津市48所幼儿园20041名3~6岁儿童末梢血,采用东芝120全自动生化分析仪检测血浆总胆固醇(TC)

  6. Blood creatinine level in postmortem cases.

    Science.gov (United States)

    Nishida, Atsushi; Funaki, Hironao; Kobayashi, Masaki; Tanaka, Yuka; Akasaka, Yoshihisa; Kubo, Toshikazu; Ikegaya, Hiroshi

    2015-05-01

    Blood chemical analysis for the diagnosis of diseases in forensic cases should be conducted in the same way as for clinical cases. However, it is sometimes difficult to obtain serum samples in forensic cases because of postmortem changes such as hemolysis and putrefaction. This study aimed to evaluate renal function in postmortem cases by blood creatinine analysis. The blood creatinine level was measured by high performance liquid chromatography (HPLC) using whole blood samples taken from 77 postmortem cases, and the relationships between blood creatinine level, postmortem interval, and cause of death were examined. The median blood creatinine level was found to be 1.15 mg/dL, with no significant differences between blood samples taken from different parts of the body. The blood creatinine level was stable for 3 days after death and gradually increased after that period, in line with a previous study using enzymatic analysis that found the serum creatinine level was stable in the early postmortem period. The blood creatinine level was high in the cases of blunt injury, intoxication, and in deaths caused by fire. This was considered to reflect acute renal dysfunction. However, the postmortem blood creatinine level remained higher than the clinical normal value despite omitting cases with renal dysfunction from the analysis. Therefore, we next investigated the change in postmortem creatinine levels in mice and found that the blood creatinine level increased with the emergence of rigor mortis. Our findings indicate that HPLC is useful in the postmortem evaluation of renal function even in the cases where serum cannot be obtained. However, the presence of rigor mortis should be considered in the evaluation of blood creatinine values.

  7. EFFECTS OF DIETARY LIPID LEVELS ON GROWTH PERFORMANCE, NUTRIENT DIGESTIBILITY AND BLOOD BIOCHEMICAL INDICES OF GIFT TILAPIA (OREOCHROMIS NILOTICUS)%饲料脂肪水平对吉富罗非鱼生产性能、营养物质消化及血液生化指标的影响

    Institute of Scientific and Technical Information of China (English)

    王爱民; 韩光明; 封功能; 杨文平; 郭家豪; 王恬; 徐跑

    2011-01-01

    In order to determine the optimal levels of the lipid of GIFT strain Nile tilapia (Oreochromis niloticus), 630 GIFT with average weight of (2.63±0. 16) g were divided into six groups (1.73% lipid, 3.71% lipid, 5.69% lipid, 7.67% lipid, 9.64% lipid and 16.55% lipid) randomly. One with triplication was the control group fed with basal diet (1.73% lipid), the others were the treated groups fed with basal diet (1.73% lipid) supplemented with 2%, 4%, 6%, 8% and 15% fish oil, respectively. After rearing 90d, the growth, feed conversion ratio, nutrient apparent digestibility and blood biochemical parameter were determined. Results showed that, along with dietary lipid level raising, weight gain rate and specific growth rate had a trend of going up first then falling down (P<0.05), protein efficiency ratio improved (P<0.01) and feed conversion ratio reduced (P<0.01). Second-order regression of weight gain rate on concentrations of dietary lipid indicated that the optimal dietary lipid for maximal growth of GIFT tilapia was about 9.34%. Crude protein and dry-matter digestibility had no significant effected by dietary lipid levels (P>0.05). Crude lipid and phosphorus digestibility raised significantly with dietary lipid level increasing (P<0.05). Albumin and albumin/globulin ratio in 1.73% group (this group did not added fish oil) was significantly higher than other group (P<0.05). Along with dietary lipid level raising, cholesterol and alkaline phosphatase of fish serum raised significantly (P<0.01). Dietary lipid level had significantly influence on blood glucose (P<0.05), and there was no significantly influence on the content of triglyceride and the activities of glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase (P>0.05). It indicated that the level of lipid in the dietary could improve the growth, the apparent digestibilities of crude lipid and phosphorus to some degree, but excessive amount of lipid

  8. Blood Triglycerides Levels and Dietary Carbohydrate Indices in Healthy Koreans

    Science.gov (United States)

    Kang, Ji Yeon

    2016-01-01

    Objectives: Previous studies have obtained conflicting findings regarding possible associations between indices measuring carbohydrate intake and dyslipidemia, which is an established risk factor of coronary heart disease. In the present study, we examined cross-sectional associations between carbohydrate indices, including the dietary glycemic index (GI), glycemic load (GL), total amount of carbohydrates, and the percentage of energy from carbohydrates, and a range of blood lipid parameters. Methods: This study included 1530 participants (554 men and 976 women) from 246 families within the Healthy Twin Study. We analyzed the associations using a generalized linear mixed model to control for familial relationships. Results: Levels of the Apo B were inversely associated with dietary GI, GL, and the amount of carbohydrate intake for men, but these relationships were not significant when fat-adjusted values of the carbohydrate indices were used. Triglyceride levels were positively associated with dietary GI and GL in women, and this pattern was more notable in overweight participants (body mass index [BMI] ≥25 kg/m2). However, total, low-density lipoprotein and high-density lipoprotein cholesterol levels were not significantly related with carbohydrate intake overall. Conclusions: Of the blood lipid parameters we investigated, only triglyceride levels were positively related with dietary carbohydrate indices among women participants in the Healthy Twin Study, with an interactive role observed for BMI. However, these associations were not observed in men, suggesting that the association between blood lipid levels and carbohydrate intake depends on the type of lipid, specific carbohydrate indices, gender, and BMI. PMID:27255074

  9. The Influence of Eleutheroside on Blood Glucose and Blood Lipid of D-Galactose-Induce Rats through Inhibiting Blood Superoxide Dismutase Activities

    Directory of Open Access Journals (Sweden)

    Ping Yang

    2013-07-01

    Full Text Available The present study aims at evaluation mechanisms of natural plant eleutheroside extracts for ameliorating the blood lipid and blood glucose. The eleutherosides derived from the roots of eleutheroccus senticosus and is purported to behave as an “adaptogen”, we assessed effects of eleutheroside at doses of 3.6, 7.2 and 14.4 g/(kg day on SD rats injected daily with D-gal (50 mg/(kg day. Eleutheroside-fed rats showed higher the level HDL-C, decrease the level of HCT, TG, TC, LDL-C compared with D-gal-treated rats. We further examined the mechanisms involved in effects of 3.63.6, 7.2 and 14.4 g/(kg day on rat blood. In summary, eleutheroside significantly increased Superoxide Dismutase (SOD activity and decreased the Malondialdehyde (MDA level.

  10. Assessing plasma glucose and lipid levels, body weight and acute ...

    African Journals Online (AJOL)

    Assessing plasma glucose and lipid levels, body weight and acute toxicity following oral ... Diabetes was induced in male and female Wistar rats with alloxan ... had good hypoglycemic activity and good effects on cardiovascular risk factors.

  11. Lipid levels in dissociative disorders: effects of psychodynamic psychotherapy.

    Science.gov (United States)

    Damsa, Cristian; Lazignac, Coralie; Miller, Nick; Maris, Susanne; Adam, Eric; Rossignon, Kevin

    2014-09-01

    Although there are several data suggesting a link between lower lipids levels and the risk of suicide, there are few data concerning lower lipids levels in patients with dissociative disorders (DD). This is the first longitudinal study investigating the evolution of the lipids levels during a specific 8 weeks of psychodynamic psychotherapy (PP) for patients with DD. 32 patients diagnosed with DD (SCID for DSMIVR) were assessed with Dissociative Experiences Scale (DES), Clinical Global Impression and Improvement Scale and their lipids levels (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and very low density lipoprotein) were measured at inclusion and after 3 and 8 weeks of PP. 30 patients finished the study. There is a significant positive (p dissociation (DES scores) at the beginning and at the end of the study. Interestingly, we found a significant (p = 0.018) positive link between the reduction of the dissociation (DES) and the increase of the triglycerides levels after 8 weeks of treatment. While lower lipids seems related to a higher level of dissociation before and after the treatment, an increasing triglycerides level was observed after 8 weeks of PP in patients with a better outcome. Further studies are needed with larger samples and control groups, in order to confirm these preliminary data. These findings could open the way for hypothesis about the role of lipids in the pathophysiology of DD and raise the question of the patients with DD receiving antilipidemiants agents.

  12. Blood Lipid Profile and Prevalence of Dyslipidemia in Chinese Adults

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To investigate the plasma lipid levels in a national representative sample of subjects and to determine the prevalence of dyslipidemia in the Chinese population. Methods Plasma lipid profile was analyzed using the data obtained during the Chinese national nutrition and health survey (CNHS) in 2002 which involved 14 252 participants at the age of 18 years or older. Results The mean levels of total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) in the participants were 3.81 mmol/L, 1.10 mmol/L, and 1.30 mmol/L, respectively. In the groups of participants at the age of 18-44 years, 45-59 years, and over 60 years the mean TC level was 3.70 mmol/L, 4.09 mmol/L and 4.21 mmol/L,respectively, and the mean TG level was 07 mmol/L, 1.21 mmol/L, 1.20 mmol/L, 1.29 mmol/L, 1.33 mmol/L, and 1.33 mmol/L,respectively. The prevalence of dyslipidemia in Chinese adults was 18.6% and 22.2% in males and 15.9% in females.Dyslipidemia prevalence was higher in urban districts than in rural areas (21.0% vs. 17.7%). The prevalence of hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterol was 2.9%, 11.9%, and 7.4% respectively among the participants. Conclusion Dyslipidemia has become one of the important health risk factors in the Chinese population. There is no significantly difference in the prevalence of dyslipidemia between the groups of participants at the age of 45-59 years and over 60 years. This study provides important lipid profile data for policy making and guideline development for the prevention of dyslipidemia in the Chinese population.

  13. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial.

    Science.gov (United States)

    Badar, Ahmed; Kaatabi, Huda; Bamosa, Abdullah; Al-Elq, Abdulmohsen; Abou-Hozaifa, Bodour; Lebda, Fatma; Alkhadra, Akram; Al-Almaie, Sameeh

    2017-01-01

    Diabetic patients with hypertension and dyslipidemia are at a high risk of cardiovascular complications. To determine the effect of Nigella sativa supplementation on the lipid profile, mean arterial pressure, and heart rate in persons with type 2 diabetes on oral hypoglycemic agents (OHA). Single-blind, nonrandomized. Diabetes clinic of a university hospital in Saudi Arabia. Type-2 diabetic patients were recruited by purposive sampling and assigned to treatment or control at the discretion of the investigator with the patient blinded to treatment. Before the in.tervention and every 3 months thereafter until the end of the treatment period, the following parameters were measured: triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and body mass index (BMI). Results at the baseline and each subsequent visit were compared between the two groups. Lipid and cardiovascular parameters, and BMI. Fifty-seven patients were assigned to receive N sativa 2 g daily for one year and 57 were assigned to receive an identical regimen of placebo, along with OHA. A significant decrease in HDL-C and increase in the TC/HDL-C and LDL-C/HDL-C ratios were seen in the control group. The N sativa group had a signifi.cant decline in TC, LDL-C, TC/HDL-C and LDL-C/HDL-C ratios, compared with the respective baseline data and the control group. HDL-C was significantly elevated in the N sativa group. The control group showed a significant elevation in MAP. The N sativa group had a significant reduction in SBP, DBP, MAP and HR and a significant decrease in DBP, MAP and HR as compared with the control group. N sativa supplementation improves total cholesterol, mean arterial pressure and heart rate in type 2 diabetes patients on oral hypoglycemic agents. There were 9 subjects in each group lost to follow up

  14. [Secular trends in blood lipid disorders among adolescents: population study in Novosibirsk (1989-2003)].

    Science.gov (United States)

    Denisova, D V; Nikitin, Iu P; Zav'ialova, L G; Burakova, S V; Ivanova, M V

    2007-01-01

    Hyperlipidemia is a known risk factor of coronary artery disease. The reduction of elevated serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in childhood may reduce cardiovascular morbidity and mortality in adulthood. Aim of the study was to assess prevalence and trends in lipid profile and lipid disorders in adolescent population in Novosibirsk (1989-2003). Four cross-sectional surveys of school children aged 14-17 years in 1989 (n=656), in 1994 (n=620), in 1999 (n=626) and in 2003 (n=667) were carried out. Total sample was 2569 (1214 males and 1355 females). Blood total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were measured by enzymatic methods. LDL-C was calculated with Friedwald's formula. Associations of blood lipids with age, sex, year of study, body mass index (kg/m2), blood pressure and main nutrients of diet were measured by GLM method. Prevalence of dyslipidemia was evaluated with NCEP-peds criteria. Diet was estimated using 24-hour dietary recall. During the 15-year period (1989-2003) mean serum TC decreased from 175 to 162 mg/dl in males and from 191 to 175 mg/dl in females (p dislipidemias in adolescents of Novosibirsk significantly changed following the changes of body mass index and diet.

  15. Physical fitness among urban and rural Ecuadorian adolescents and its association with blood lipids: a cross sectional study

    Science.gov (United States)

    2014-01-01

    Background Physical fitness has been proposed as a marker for health during adolescence. Currently, little is known about physical fitness and its association with blood lipid profile in adolescents from low and middle-income countries. The aim of this study is therefore to assess physical fitness among urban and rural adolescents and its associations with blood lipid profile in a middle-income country. Methods A cross-sectional study was conducted between January 2008 and April 2009 in 648 Ecuadorian adolescents (52.3% boys), aged 11 to 15 years, attending secondary schools in Cuenca (urban n = 490) and Nabón (rural n = 158). Data collection included anthropometric measures, application of the EUROFIT battery, dietary intake (2-day 24 h recall), socio-demographic characteristics, and blood samples from a subsample (n = 301). The FITNESGRAM standards were used to evaluate fitness. The associations of fitness and residential location with blood lipid profile were assessed by linear and logistic regression after adjusting for confounding factors. Results The majority (59%) of the adolescents exhibited low levels of aerobic capacity as defined by the FITNESSGRAM standards. Urban adolescents had significantly higher mean scores in five EUROFIT tests (20 m shuttle, speed shuttle run, plate tapping, sit-up and vertical jump) and significantly most favorable improved plasma lipid profile (triglycerides and HDL) as compared to rural adolescents. There was a weak association between blood lipid profile and physical fitness in both urban and rural adolescents, even after adjustment for confounding factors. Conclusions Physical fitness, in our sample of Ecuadorian adolescents, was generally poor. Urban adolescents had better physical fitness and blood lipid profiles than rural adolescents. The differences in fitness did not explain those in blood lipid profile between urban and rural adolescents. PMID:24745348

  16. Effects of soy components on blood and liver lipids in rats fed high-cholesterol diets

    Institute of Scientific and Technical Information of China (English)

    Ching-Yi Lin; Cheng-Yu Tsai; Shyh-Hsiang Lin

    2005-01-01

    AIM: To assess the effects of soy protein, isoflavone, and saponin on liver and blood lipid in rats that consumed high-cholesterol diets.METHODS: High-cholesterol diets (1%) with or without soy material were fed to 6-wk-old male Sprague-Dawley rats for 8 wk. Blood lipids, liver lipids, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) levels were measured. The in vitro bile acid-binding ability of soy materials was analyzed.RESULTS: The results of in vitro studies showed that soy protein isolate had a significantly higher bile acid-binding ability (8.4±0.8%) than soy saponin (3.1±0.7%) and isoflavone (1.3±0.4%, P<0.05). On the other hand, at the end of the experimental period, rats that consumed soy protein diets had lower GOT and GPT levels than rats that consumed casein under high-cholesterol diets.Rats that consumed soy protein also had lower total cholesterol (TC) levels in the liver than those that consumed casein under high-cholesterol diets. Rats that consumed the soy protein diet containing both saponin and isoflavone had lower hepatic TC level than those that consumed the soy protein diet without isoflavone alone.The effect of different types of proteins on triglyceride was not significant.CONCLUSION: Consumption of soy provided benefits to control lipid levels under high-cholesterol dieting conditions in this rat model of hypercholesterolemia. The major component that reduced hepatic TC was not saponin, but possibly isoflavone.

  17. Blood F2-isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis

    Institute of Scientific and Technical Information of China (English)

    Man-Sie Zhu; Li-Juan Sun; Yue-Qin Uu; Yan-Ling Feng; Hai-Tao Tong; Ying-He Hu; Zheng Zhao

    2008-01-01

    AIM: To investigate oxidative stress and lipid peroxi-dation in hepatic steatosis and the underlying implica-tions in pathological mechanisms of non-alcoholic fatty liver disease (NAFLD).METHODS: F2-isoprostanes (iPF2α-Ⅲ) in blood and liver samples from steatotic (n = 9) and control (n = 7)rats were measured as in vivo marker of lipid peroxida-tion by a mass spectrometric approach. The lipid pro-file and endogenous antioxidant status (SOD and CAT)in the rats were also analyzed.RESULTS: Significantly higher levels of iPF2α-Ⅲ (mean3.47 vs 2.40 pmol/mg tissue, P = 0.004) and lower activities of SOD (mean 1.26 U vs 1.40 U, P < 0.001) and CAT (mean 1026.36 U/mg vs 1149.68 U/mg pro-tein, without significance) were observed in the livers of steatotic rats. Plasma total iPF2α-Ⅲ was significantly correlated with the abnormalities of blood lipids as well as alanine aminotransferase (ALT) levels in the rats with simple steatosis, whereas no similar tendencies were observed in the control rats.CONCLUSION: Enhancement of hepatic oxidative imbalance occurring at the steatotic stage of NAFLD suggests a possibility that manifestation of the local oxidative damage precedes that of systemic oxidativeimbalance. Predominant metabolic features of the in-creased lipid peroxidation further suggest a close asso-ciation of the oxidative imbalance and the dyslipidemia with functional deterioration of the steatotic liver. The findings need to be further evaluated, especially in hu-man studies.

  18. The Relation between Thyroid Hormone and Blood Lipid in the Healthy Elderly

    Institute of Scientific and Technical Information of China (English)

    何凤屏; 李山; 洗苏; 刘广钊; 夏宁

    2002-01-01

    Objectives To observethe relationship between Thyroid Hormone (TH) leveland blood lipid level in the healthy elderly with therapyof small dose of TH. Methods A total of 120healthy old persons were randomly divided into twogroups: 60 old persons as treatment group and other 60persons as control group. Each person in the treatmentgroup took a thyroid tablet 10 mg daily continuously forsix months while the control group took VitB1 30 mgdaily instead of thyroid tablet. The level of TH, M -TSH, FT3, FT4, TT4, rT3, TC, TG, LDL- C, HDL-C, ApoA1 were measured in two groups before andafter receiving TH or Vit. B1 treatment. Results Inthe treatment group the level of TH increased obvious-ly. And TC, TG, LDL- C levels decreased also tosome extent while HDL- C, ApoA1 levels increasedslightly which was significant when compared with thecontrol group and pre- treatment group. ConclusionsTo use small dose of TH as supplement treatmentcan increase the TH level of healthy old persons anddecrease their blood lipid level. It would be a benefitfor treating hyperlipidemia in the elderly.

  19. Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid

    Directory of Open Access Journals (Sweden)

    Dwi Laksono Adiputro

    2015-12-01

    Full Text Available BACKGROUND In cardiovascular medicine, Garcinia mangostana has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The effect of Garcinia mangostana on hyperlipidemia is unknown. The aim of this study was to evaluate the effect of an ethanolic extract of Garcinia mangostana pericarp on lipid profile in rats fed a high lipid diet. METHODS A total of 40 rats were divided into five groups control, high lipid diet, and high lipid diet + ethanolic extract of Garcinia mangostana pericarp at dosages of 200, 400, and 800 mg/kg body weight. The control group received a standard diet for 60 days. The high lipid diet group received standard diet plus egg yolk, goat fat, cholic acid, and pig fat for 60 days with or without ethanolic extract of Garcinia mangostana pericarp by the oral route. After 60 days, rats were anesthesized with ether for collection of blood by cardiac puncture. Analysis of blood lipid profile comprised colorimetric determination of cholesterol, triglyceride, low density lipoprotein (LDL, and high density lipoprotein (HDL. RESULTS From the results of one-way ANOVA it was concluded that there were significant between-group differences in cholesterol, trygliceride, LDL, and HDL levels (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly decreased cholesterol, trygliceride, and LDL levels, starting at 400 mg/kg body weight (p=0.000. Ethanolic extract of Garcinia mangostana pericarp significantly increased HDL level starting at 200 mg/kg body weight (p=0.000. CONCLUSION Ethanolic extract of Garcinia mangostana pericarp has a beneficial effect on lipid profile in rats on a high lipid diet.

  20. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice.

    Directory of Open Access Journals (Sweden)

    Elise F Hoek-van den Hil

    Full Text Available Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD. In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control or with supplementation of 0.33% (w/w quercetin for 12 weeks. Gas chromatography and (1H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG were decreased with 14% (p<0.001 and total poly unsaturated fatty acids (PUFA were increased with 13% (p<0.01. Palmitic acid, oleic acid, and linoleic acid were all decreased by 9-15% (p<0.05 in quercetin-fed mice. Both palmitic acid and oleic acid can be oxidized by omega (ω-oxidation. Gene expression profiling showed that quercetin increased hepatic lipid metabolism, especially ω-oxidation. At the gene level, this was reflected by the up-regulation of cytochrome P450 (Cyp 4a10, Cyp4a14, Cyp4a31 and Acyl-CoA thioesterase 3 (Acot3. Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3 were also up-regulated in the quercetin-fed mice. We conclude that quercetin intake increased hepatic lipid ω-oxidation and lowered corresponding circulating lipid levels, which may contribute to potential beneficial effects on CVD.

  1. Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice.

    Science.gov (United States)

    Hoek-van den Hil, Elise F; Keijer, Jaap; Bunschoten, Annelies; Vervoort, Jacques J M; Stankova, Barbora; Bekkenkamp, Melissa; Herreman, Laure; Venema, Dini; Hollman, Peter C H; Tvrzicka, Eva; Rietjens, Ivonne M C M; van Schothorst, Evert M

    2013-01-01

    Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism, mice received a mild-high-fat diet without (control) or with supplementation of 0.33% (w/w) quercetin for 12 weeks. Gas chromatography and (1)H nuclear magnetic resonance were used to quantitatively measure serum lipid profiles. Whole genome microarray analysis of liver tissue was used to identify possible mechanisms underlying altered circulating lipid levels. Body weight, energy intake and hepatic lipid accumulation did not differ significantly between the quercetin and the control group. In serum of quercetin-fed mice, triglycerides (TG) were decreased with 14% (p<0.001) and total poly unsaturated fatty acids (PUFA) were increased with 13% (p<0.01). Palmitic acid, oleic acid, and linoleic acid were all decreased by 9-15% (p<0.05) in quercetin-fed mice. Both palmitic acid and oleic acid can be oxidized by omega (ω)-oxidation. Gene expression profiling showed that quercetin increased hepatic lipid metabolism, especially ω-oxidation. At the gene level, this was reflected by the up-regulation of cytochrome P450 (Cyp) 4a10, Cyp4a14, Cyp4a31 and Acyl-CoA thioesterase 3 (Acot3). Two relevant regulators, cytochrome P450 oxidoreductase (Por, rate limiting for cytochrome P450s) and the transcription factor constitutive androstane receptor (Car; official symbol Nr1i3) were also up-regulated in the quercetin-fed mice. We conclude that quercetin intake increased hepatic lipid ω-oxidation and lowered corresponding circulating lipid levels, which may contribute to potential beneficial effects on CVD.

  2. 精神分裂症患者醌氧化还原酶1 C609T 多态性与血脂水平相关性研究%The correlation of quinone oxidoreductase 1 gene C609T poly-morphism and blood lipid levels of schizophrenia patients

    Institute of Scientific and Technical Information of China (English)

    张炳奎; 杨保春; 赵若莲

    2014-01-01

    目的:探讨醌氧化还原酶1 C609 T 基因多态性与精神分裂症患者血脂水平的相关性。方法对328例精神分裂症患者血脂水平及醌氧化还原酶1 C609 T基因多态性进行检测分析。结果本组患者醌氧化还原酶1 C609T位点CC、CT 和 T T基因型频率分别为43.9%、42.1%和14.0%;C和T等位基因频率分别为66.3%和33.7%。醌氧化还原酶1 C609T基因型频率、等位基因频率与患者血脂水平均无显著相关性(P>0.05)。结论醌氧化还原酶1基因C609T位点在精神分裂症患者中存在多态性,其基因型频率、等位基因频率与患者的血脂水平无显著相关性。%Objective To explore the correlation of quinone oxidoreductase 1 (NAD (P) H :quinone oxidoreductase l ,NQO1) gene C609T polymorphism and blood lipid levels of schizophrenia patients .Methods Blood lipid levels and NQO1 gene C609T polymor-phism were detected and analyzed in 328 schizophrenia patients .Results The frequency of genotype CC , CT and TT at NQO1 locus C609T was 43 .9% ,42 .1% and 14 .0% respectively ;C and T allele frequency were 66 .3% and 33 .7% respectively .Both NQO1 C609T genotype and allele frequency had no obvious cor-relation to blood lipid levels (P> 0 .05) .Conclusion Schizophrenia patients have NQO1 gene C609T pol-ymorphisms ,its genotype and allele frequency had no obvious correlation to blood lipid levels .

  3. Association between blood cholesterol level with periodontal status of coronary heart disease patients

    Science.gov (United States)

    Valensia, Rosy; Masulili, Sri Lelyati C.; Lessang, Robert; Radi, Basuni

    2017-02-01

    Coronary heart disease (CHD) is an abnormal narrowing of heart arteries associated with local accumulation of lipids, in the form of cholesterol and triglycerides. Periodontal disease is a chronic inflammatory that suggests link to the development of CHD. In periodontitis have been reported changes in lipid profile, include increased of cholesterol levels of blood. Objective: to analyse correlation between blood cholesterol level with periodontal status of CHD and non CHD subjects. Methods: Periodontal status and blood cholesterol level of 60 CHD and 40 non CHD subjects was measured. Result: Blood cholesterol level in CHD subjects differs from non CHD subjects (p=0.032). Blood cholesterol level correlates with pocket depth (p=0.003) and clinical attachment loss (CAL) (p=0.000) in CHD subjects. Blood cholesterol level correlates with pocket depth (p=0.010) in non CHD subjects. There is no significant correlation between blood cholesterol level and bleeding on probing (BOP) in CHD subjects. There is no significant correlation between blood cholesterol level with BOP and CAL in non CHD subjects. Conclusion: Blood cholesterol level in control group is higher than CHD patients. Blood cholesterol level positively associated with pocket depth (r=0.375) and CAL (r=0.450) in CHD patients. Blood cholesterol level is positively associated with pocket depth (r=0.404) in control group.

  4. Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

    Institute of Scientific and Technical Information of China (English)

    Zhe Yan; Yang Liu; Hui Huang

    2012-01-01

    Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type2 diabetes with glycosylated hemoglobin (HbA1c).Methods:Samples were collected from 128 type2 diabetic patients (aged19-90 years; male 72, female56). The sera were analyzed for HbA1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to theHbA1c level, the patients were divided into three groups, groupA (HbA1c 10%,n=49). The correlation ofHbA1cwith lipid ratios & individual lipid indexes were analyzed.Results:With the increased level ofHbA1c,LDL-C had a significantly increasing trend (P<0.05); whereasTC went up with the increasedHbA1c, without any significant differences between three groups. There was no significant correlation betweenHbA1c andTG or HDL-C. With the increased level ofHbA1c,TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especiallyLDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism inT2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type2 diabetic patients.

  5. blood glucose level in Bufo gutturalis (power)

    African Journals Online (AJOL)

    Department of Human Physiology and Physiological Chemistry, ... the influence of dehydration on the blood glucose level of anurans. .... J. Cell. Compo Physiol. 44: 233 - 246. VAWDA, A. 1978. The loss of sodium across the skin of the.

  6. Hyperestrogenemia and increased blood mercury level

    Institute of Scientific and Technical Information of China (English)

    Viroj Wiwanitkit

    2012-01-01

    Hyperestrogenemia is an important reproductive hormone abnormality. This condition is not common in male patients. In this report, the author presents a case study on hyperestrogenemia with increased blood mercury level. The metalloestrogen phenomenon is discussed.

  7. [LEVEL 1--a new blood warming device].

    Science.gov (United States)

    Arndt, M; Hofmockel, R; Benad, G

    1994-01-01

    Hypothermia of less than 35 degrees C, which frequently occurs in connection with massive blood transfusion, is a serious problem in many patients, in particular in those with polytrauma. The restoration of normal body temperature is very important and requires the use of a rapidly-acting, efficient and safe blood warmer, which is able to work effectively at high flow-rates. The LEVEL 1 (Technologies, Rockland, MA) is such a new blood warmer and works as a heat-exchanger via an aluminium column. This system is highly effective. Six hundred ml of sodium chloride 0.9% are warmed from 4 to 35 degrees C within one minute. This device is quickly operational and has a low priming volume. The LEVEL 1 is the only device currently available which is able to warm blood sufficiently during a very rapid blood transfusion.

  8. Residential greenness and blood lipids in children: A longitudinal analysis in GINIplus and LISAplus.

    Science.gov (United States)

    Markevych, Iana; Standl, Marie; Sugiri, Dorothea; Harris, Carla; Maier, Werner; Berdel, Dietrich; Heinrich, Joachim

    2016-11-01

    There is some evidence of decreased cardiovascular disease (CVD) mortality and morbidity among adults residing in greener places. Among others, blood lipids are well established risk factors for CVD. In our previous study, we observed the inverse association between greenness and blood pressure in 10-year-old children. In the current study, we investigated whether there is also a link between residential greenness and blood lipids in 10- and 15-year-old children. Complete data on blood lipids (total cholesterol, HDL, LDL and triglyceride), residential greenness (NDVI in 100-m, 300- and 500-m buffers around residences) and confounders were available for 1,552 participants at 10 and 15 years of age, residing in two study areas of two German birth cohorts - GINIplus and LISAplus. Longitudinal associations between NDVI and blood lipids were assessed by generalized estimation equations. No associations were observed between residential greenness in any of the chosen buffers and blood lipids in children (e.g., change in blood lipids per interquartile increase in NDVI in 100-m buffer for total cholesterol and LDL: means ratio=1.00 (95% confidence interval: 0.99-1.01), for triglyceride: 0.98 (0.96-1.00)). No area- or sex-varying effects were evident. Change of the residence between 10 and 15 years also did not yield any consistent associations. There is no evidence of an association between greenness and blood lipids in 10- and 15-years old children. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. What are the effects of psychological stress and physical work on blood lipid profiles?

    Science.gov (United States)

    Assadi, Seyedeh Negar

    2017-05-01

    Blood lipids disorders are prevalent in the world. Some of their risk factors are modifiable such as mental and physical stress which existed in some places such as work environment.Objective of this study was to determine the effects of psychological and physical stress on the lipid profiles. It was a historical cohort study. The people who were employed as general worker were participated. The study was conducted with flexible interview for getting history, lipid profile examination, and a checklist including occupational and nonoccupational risk factors and using the health issues. According to the type of stress exposures, the study population was divided into 5 groups. Groups were followed for lipid profiles. These groups were exposed to psychological stress, physical stress or both of them; mild psychological stress (group 1), mild physical work without psychological stress (group 2), mild psychological stress and mild physical work (group 3), moderate physical work without psychological stress (group 4), and heavy physical work without psychological stress (group 5). Data were analyzed with SPSS 16. ANOVA, χ, and exact test were calculated with considering P < .05 as significant level. Relative risks were calculated with confidence interval 95%. The means of lipid profiles were in normal ranges. The relative risks for triglycerides more than 200 mg/dL was 1.57 (1.02-2.42) and low density lipoprotein (LDL) more than 130 mg/dL was 14.54 (3.54-59.65) in group 1. The relative risks for high density lipoprotein (HDL) less than 45 mg/dL was 14.61 (8.31-25.68) in group 1 and 16.00 (8.30-30.83) in group 3. After multinomial logistic regression they had significant differences. Psychological stress was a risk factor for lipid disorders, and suitable physical activity was protective in this situation.

  10. Investigation of the Effect of Chitosan and Salvadora Persica on Blood Lipids in the Wistar Rat

    Directory of Open Access Journals (Sweden)

    N Mirjalili

    2008-04-01

    Full Text Available Introduction: Hypercholesterolemia is a metabolic disorder that ultimately results in arterial sclerosis and complications like hypertension and coronary arterial diseases. Various drugs have been used for the treatment of this condition and many studies are underway for introducing new drugs. Chitosan and Salvadora Persica are two such drugs. Chitosan is produced by deacetylation of chitin which is present mainly in the exoskeleton of crustaceans. The aim of this invitro study was to study the effects of these two drugs on blood lipid levels. Methods: In this Interventional Laboratory Trial, 30 mature vistar rats weighing 200-250 grams were selected and after a period of two weeks in order to allow them to adapt to their surroundings, they were allotted randomly to 6 groups. The rats were then fed for a period of 15 days with normal or fatty diet, with or without the drugs. Chitosan in pure powder form and persica in the form of hydro alcoholic salvadora persica stem extract were added to the diet of the respective study groups. At the end of this period, blood samples were taken in order to measure cholesterol, triglyceride, HDL and LDL levels. Data was analyzed statistically using SPSS software program and Scheffe, ANOVA and Descriptive statistical tests. Results: Both chitosan and persica decreased cholesterol and LDL levels in the groups ingesting fatty diet (P 0.05. The two drugs had no effect on triglyceride and HDL levels. (P > 0.05 Both chitosan and persica had no effect on blood lipid levels of subjects on normal diet whose cholesterol levels were normal (P > 0.05. Conclusion: Persica and chitosan have similar effects on reduction of cholesterol and LDL levels in cases of hypercholesterolemia, but have no effect on triglyceride and HDL levels.

  11. Effect of carotenoid source and dietary lipid content on blood astaxanthin concentration in rainbow trout (Oncorhynchus mykiss)

    OpenAIRE

    Barbosa, M.J.; Morais, R.; Choubert, G.

    1999-01-01

    Astaxanthin concentration in the blood of rainbow trout was studied in a feeding trial with two different astaxanthin sources: green algae Haematococcus pluvialis and commercial beadlets of 8% astaxanthin content (CAROPHYLL® Pink), and two different dietary lipid levels. The green algae contained 1.4% of carotenoids on a dry matter basis: free astaxanthin (

  12. Compliance to Dietary Counselling in Controlling Blood Lipid and its Barriers among Dyslipidemic Individuals

    Directory of Open Access Journals (Sweden)

    Suhaina Sulaiman

    2016-10-01

    Full Text Available Dyslipidemia is a risk factor causing cardiovascular disease and compliance to dietary counselling results in an improved lipid profile. The present study aimed to assess the compliance to dietary counselling and its barriers among dyslipidemic individuals attending dietary follow-ups counselling in Diet Clinic of Universiti Kebangsaan Malaysia Medical Centre (UKMMC. A cross sectional study using the convenience sampling technique was conducted from May to June 2012. Data on food intake, lifestyle habits, physical activity level and barriers in adhering to dietary counselling were collected using interview-based questionnaires. Anthropometric measurements were conducted, while blood lipid profile and medical information were obtained from medical records. The results showed that non-compliance is prevalent among dyslipidemic patients who received dietary counselling. Most subjects (81% were unable to achieve at least four of the therapeutic lifestyle change dietary recommendations as outlined by National Cholesterol Education Program Adult Treatment Panel III. Factors such as time, food taste and price have been reported as the main barriers to comply towards dietary counselling. A significantly higher proportion of those in non-compliance group did not meet total fat (p < 0.001 and saturated fat (p < 0.001 recommendations as compared to the compliance group. In conclusion, acknowledgements of barriers while providing dietary education are necessary to improve dyslipidemic patients’ compliance with controlling blood lipid.

  13. The Effect of Bisphosphonate Treatment on Blood Lipid Parameters in Patients with Postmenopausal Osteoporosis

    Directory of Open Access Journals (Sweden)

    Canan Tıkız

    2005-03-01

    Full Text Available Bisphosphonates are currently the most preferred class of drugs used for the treatment of metabolic bone disease such as osteoporosis and Paget’s disease. Although their exact mechanism has not been identified, the compounds containing amino group (amino bisphosphonates were shown to decrease osteoclast activation by inhibiting mevalonate pathway. Because mevalonate pathway is essential in production of cholesterol, these compounds could also interfere with cholesterol synthesis. In the present study, the effects of aminobisphosphonates on lipid parameters in subjects who were diagnosed as osteoporosis were investigated. For this reason, 50 postmenopausal osteoporotic subjects were included in the study and 25 of them (mean age:54±9 years received alendronate sodium (70mg/week and the remaining 25 subjects (mean age:55±8 years were given risedronate sodium (35mg/week. Blood samples were analyzed at baseline and at the end of sixth months. Total cholesterol, high density cholesterol (HDL-chol, low density cholesterol (LDL-chol, triglyceride, apolipoprotein A (Apo-A, apolipoprotein B (Apo-B and lipoprotein (a (Lip a were investigated as lipid parameters. Total alkaline phophatase (TAP, bone-specific alkaline phophatase (BAP, osteocalcine (OCL and urine deoxyprydolin (DPD levels were assessed as bone remodeling markers. After six month treatment period, while significant changes were observed in bone remodeling parameters (p0.05. Our results suggest that moderate-term oral aminobisfosphonate treatment has no significant effect on blood lipid parameters.

  14. Protective Effect of Pulp Oil Extracted from Canarium odontophyllum Miq. Fruit on Blood Lipids, Lipid Peroxidation, and Antioxidant Status in Healthy Rabbits

    Directory of Open Access Journals (Sweden)

    Faridah Hanim Shakirin

    2012-01-01

    Full Text Available The aim of this paper was to compare the effects of pulp and kernel oils of Canarium odontophyllum Miq. (CO on lipid profile, lipid peroxidation, and oxidative stress of healthy rabbits. The oils are rich in SFAs and MUFAs (mainly palmitic and oleic acids. The pulp oil is rich in polyphenols. Male New Zealand white (NZW rabbits were fed for 4 weeks on a normal diet containing pulp (NP or kernel oil (NK of CO while corn oil was used as control (NC. Total cholesterol (TC, HDL-C, LDL-c and triglycerides (TG levels were measured in this paper. Antioxidant enzymes (superoxide dismutase and glutathione peroxidise, thiobarbiturate reactive substances (TBARSs, and plasma total antioxidant status (TAS were also evaluated. Supplementation of CO pulp oil resulted in favorable changes in blood lipid and lipid peroxidation (increased HDL-C, reduced LDL-C, TG, TBARS levels with enhancement of SOD, GPx, and plasma TAS levels. Meanwhile, supplementation of kernel oil caused lowering of plasma TC and LDL-C as well as enhancement of SOD and TAS levels. These changes showed that oils of CO could be beneficial in improving lipid profile and antioxidant status as when using part of normal diet. The oils can be used as alternative to present vegetable oil.

  15. The Impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms

    Directory of Open Access Journals (Sweden)

    Hamid Najafipour

    2016-10-01

    Full Text Available AbstractAim: Substance abuse has become a universal crisisin our modern age. Among illegal substances, opium and its derivatives have been ranked second in terms of usage after cannabis in the world. In many Asian regions, the use of opium enjoys a high social acceptance; hence, some common people and even medical practitioners believe that opium lowers blood glucose and pressure and treat dyslipidemia. How much this belief is scientifically justified? Method: The results of available studies on both humans and animals searched in different search engines up to mid-2016 were integrated (77 articles. Upon the findings we try to offer a more transparent picture of the effects of opium on the mentioned factors along with the probable underlying mechanisms of its action. Results: Taken together, a variety of evidences suggest that the consumption of opium has no scientific justification for amendment of these biochemical variables. The mechanisms proposed so far for the action of opium in the three above disorders are summarized at the end of the article. Short term effects seems to be mostly mediated through central nervous system (neural and hormonal mechanisms, but long term effects are often due to the structural and functional alterations in some body organs. Conclusion: Although opium may temporarily reduce blood pressure, but it increases blood glucose and most of blood lipids. Moreover its long term use has negative impacts and thus it aggravates diabetes, dyslipidemia and hypertension. Accordingly, it is necessary to inform societies about the potential disadvantages of unauthorized opium consumption.

  16. Comparison of Influences of Leflunomide and Hydroxychloroquine Sulfate on Blood Lipid Levels in Patients with Lupus Nephritis%来氟米特和硫酸羟氯喹对狼疮性肾炎患者血脂水平的影响比较

    Institute of Scientific and Technical Information of China (English)

    熊金河; 何芳; 尚华

    2015-01-01

    目的:探讨来氟米特(LEF)和硫酸羟氯喹( HCQ )对狼疮性肾炎患者血脂水平影响的差异。方法选取2010年3月至2014年3月86例维持治疗期狼疮性肾炎患者,随机分为两组,各43例,分别予LEF和HCQ治疗,观察3个月,比较两组治疗前后血脂水平。结果 LEF组治疗前后血脂水平无显著差异( P>0.05);HCQ组治疗前后三酰甘油(TG)分别为(1.98±0.33)mmol/L比(1.74±0.36)mmol/L ( P<0.01),总胆固醇(TC)为(4.69±0.65)mmol/L比(4.39±0.58)mmol/L( P<0.05);治疗前两组间各血脂成分无显著差异( P>0.05),治疗后 LEF 组和 HCQ组 TG 分别为(1.91+0.35)mmol/L 比(1.74±0.36)mmol/L( P<0.05),TC 分别为(4.71±0.67) mmol/L 比(4.39±0.58)mmol/L( P<0.05)。结论硫酸羟氯喹和来氟米特均能缓解狼疮肾炎患者的病情,但前者可降低患者血脂水平,从而减少心血管事件发生的风险。%Objective To compare the difference in the influences of leflunomide and hydroxychloroquine sulfate on blood lipid levels in the patients with lupus nephritis. Methods 86 patients with lupus nephrites treated by the maintenance treatment from March 2010 to March 2014 were randomly assigned to the leflunomide ( LEF ) group and the hydroxychloroquine sulfate ( HCQ ) group,each of them were 43 Cases. The two groups were respectively treated by leflunomide and hydroxychloroquine sulfate for 3 months. The blood lipid level before and after treatment were examined and compared between the two groups. Results The blood lipid levels in the LEF group has no statistical difference between before and after treatment ( P > 0. 05 );the blood lipid level after treatment in HCQ group has statistically significant statistical difference compared with before treatment [ triglyceride ( TG ): ( 1. 98 ± 0. 33 ) vs. ( 1. 74 ± 0. 36 ) mmol/L, P 0. 05 ) , but the blood TG and TC levels after treatment had statistically

  17. Veganism Is a Viable Alternative to Conventional Diet Therapy for Improving Blood Lipids and Glycemic Control.

    Science.gov (United States)

    Trepanowski, John F; Varady, Krista A

    2015-01-01

    The American Diabetes Association (ADA) and the National Cholesterol Education Program (NCEP) have each outlined a set of dietary recommendations aimed at improving glycemic control and blood lipids, respectively. However, traditional vegan diets (low-fat diets that proscribe animal product consumption) are also effective at improving glycemic control, and dietary portfolios (vegan diets that contain prescribed amounts of plant sterols, viscous fibers, soy protein, and nuts) are also effective at improving blood lipids. The purpose of this review was to compare the effects of traditional vegan diets and dietary portfolios with ADA and NCEP diets on body weight, blood lipids, blood pressure, and glycemic control. The main findings are that traditional vegan diets appear to improve glycemic control better than ADA diets in individuals with type 2 diabetes mellitus (T2DM), while dietary portfolios have been consistently shown to improve blood lipids better than NCEP diets in hypercholesterolemic individuals.

  18. Treatment goals for ambulatory blood pressure and plasma lipids after stroke are often not reached

    DEFF Research Database (Denmark)

    Engberg, Aase Worså; Kofoed, Klaus

    2013-01-01

    In Danish health care, secondary prevention after stroke is currently handled mainly by general practitioners using office blood pressure (OBP) assessment of hypertension. The aim of this study was to compare the OBP approach to 24-hour assessment by ambulatory blood pressure (ABP) monitoring....... Furthermore, we aimed to record the degree of adherence to recommended therapy goals for blood pressure and plasma lipids....

  19. Treatment goals for ambulatory blood pressure and plasma lipids after stroke are often not reached

    DEFF Research Database (Denmark)

    Engberg, Aase Worså; Kofoed, Klaus

    2013-01-01

    In Danish health care, secondary prevention after stroke is currently handled mainly by general practitioners using office blood pressure (OBP) assessment of hypertension. The aim of this study was to compare the OBP approach to 24-hour assessment by ambulatory blood pressure (ABP) monitoring. Fu....... Furthermore, we aimed to record the degree of adherence to recommended therapy goals for blood pressure and plasma lipids....

  20. Relationship between microalbuminuria level and carotid atherosclerosis in patients with hypertension and normal blood lipid%血脂正常原发性高血压患者微量白蛋白尿与颈动脉粥样硬化的关系

    Institute of Scientific and Technical Information of China (English)

    张国天; 陈永生

    2012-01-01

    Objective To investigate the relationship between microalbuminuria level and carotid atherosclerosis in patients with hypertension and normal blood lipid. Methods A total of 169 patients with primary hypertension and normal blood lipid were divided into carotid atherosclerosis plaque group (92 cases) and non-carotid atherosclerosis plaque group (77 cases) after the measurement of intima-media thickness of bilateral carotid arteries by ultrasonography. The degree of carotid atherosclerosis was divided into 0 to 4 levels. The level of microalbuminuria was detected. Results The level of microalbuminuria was significantly higher in carotid atherosclerosis plaque group than that in non-carotid atherosclerosis plaque group(P<0. 01). There was a significant difference in microalbuminuria level between each two carotid atherosclerosis degrees from 0 to 4(P<0. 05). Conclusion The formation of carotid atherosclerosis plaque is positively correlated with the increased microalbuminuria level in patients with hypertension and normal blood lipid.%目的 探讨血脂正常的原发性高血压患者微量白蛋白尿与颈动脉粥样硬化(carotid atherosclerosis,CAS)的关系.方法 血脂正常的原发性高血压患者169例,行颈动脉彩色多普勒超声检查,测量左、右颈动脉内膜-中层厚度,根据测量结果分为斑块组92例与无斑块组77例,将CAS分为0-4级并检测尿微量白蛋白水平.结果 斑块组尿微量白蛋白水平高于无斑块组(P<0.01);CAS 0,1,2,3,4级尿微量白蛋白水平比较差异均有统计学意义(P<0.05).结论 血脂正常的原发性高血压患者微量白蛋白尿与CAS发生及程度呈正相关.

  1. Gaucher disease: plasmalogen levels in relation to primary lipid abnormalities and oxidative stress.

    Science.gov (United States)

    Moraitou, Marina; Dimitriou, Evangelia; Dekker, Nick; Monopolis, Ioannis; Aerts, Johannes; Michelakakis, Helen

    2014-01-01

    Plasmalogens represent a unique class of phospholipids. Reduced red blood cell plasmalogen levels in Gaucher disease patients were reported, correlating to total disease burden. The relation between plasmalogen abnormalities in Gaucher disease patients and primary glycosphingolipid abnormalities, malonyldialdehyde levels, an indicator of lipid peroxidation, and the total antioxidant status was further investigated. Significant reduction of C16:0 and C18:0 plasmalogens in red blood cells of Gaucher disease patients was confirmed. In parallel, a significant increase in the glucosylceramide/ceramide ratio in red blood cell membranes, as well as an average 200-fold increase in plasma glucosylsphingosine levels was observed. Red blood cell malonyldialdehyde levels were significantly increased in patients, whereas their total antioxidant status was significantly reduced. A negative correlation between plasmalogen species and glucosylceramide, ceramide, glucosylceramide/ceramide ratio, glucosylsphingosine and malonyldialdehyde, significant for the C16:0 species and all the above parameters with the exception of malonyldialdehyde levels, was found along with a positive non-significant correlation with the total antioxidant status. Our results indicate that increased lipid peroxidation and reduced total antioxidant status exist in Gaucher disease patients. They demonstrate a clear link between plasmalogen levels and the primary glycolipid abnormalities characterizing the disorder and an association with the increased oxidative stress observed in Gaucher disease patients.

  2. Comparison of Blood Lipids, Blood Pressures and Left Ventricular Cavity Dimension between Soccer Players and Non-Athletes

    Science.gov (United States)

    Gokhan, Ismail; Kurkcu, Recep; Cekin, Resul

    2013-01-01

    In this study, it was aimed to compare the investigate the effects of regular exercise on blood lipids, blood pressure and left ventricular cavity dimensions function between soccer players and non-athletes in football players. This study consisted included a total of 30 subjects, including an experimental group including 18 soccer players…

  3. Comparison of Blood Lipids, Blood Pressures and Left Ventricular Cavity Dimension between Soccer Players and Non-Athletes

    Science.gov (United States)

    Gokhan, Ismail; Kurkcu, Recep; Cekin, Resul

    2013-01-01

    In this study, it was aimed to compare the investigate the effects of regular exercise on blood lipids, blood pressure and left ventricular cavity dimensions function between soccer players and non-athletes in football players. This study consisted included a total of 30 subjects, including an experimental group including 18 soccer players…

  4. Net energy levels on the lipid profile of pork

    Directory of Open Access Journals (Sweden)

    Stephan Alexander da Silva Alencar

    2017-09-01

    Full Text Available ABSTRACT: This study was conducted to evaluate the effects of net energy levels on the lipid profile of adipose tissue and muscle of swines. A total of 90 animals, with initial weight of 71.94±4.43kg, were used, and distributed in a randomized block design in five net energy levels (2,300, 2,425, 2,550, 2,675, and 2,800Kcal kg-1 feed, with nine replicates and two animals per experimental unit. Lipid profiles of adipose tissue and muscle were analyzed using gas chromatography. Increasing the levels of net energy using soybean oil, improved the lipid profile of adipose tissue and muscle, increased linearly (P<0.05 the concentrations of polyunsaturated fatty acids, especially linoleic and α-linolenic acid, reduced linearly (P<0.05 the monounsaturated and saturated fatty acids and omega 6: omega 3. In adipose tissue was observed linear reduction (P<0.05 of atherogenic and thrombogenic indexes. In conclusion, increasing the level of net energy of the diet using soybean oil improved the lipid profile of adipose tissue and muscle.

  5. Discovery and refinement of loci associated with lipid levels

    NARCIS (Netherlands)

    Willer, Cristen J; Schmidt, Ellen M; Sengupta, Sebanti; Peloso, Gina M; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; Buchkovich, Martin L; Mora, Samia; Beckmann, Jacques S; Bragg-Gresham, Jennifer L; Chang, Hsing-Yi; Demirkan, Ayşe; Den Hertog, Heleen M; Do, Ron; Donnelly, Louise A; Ehret, Georg B; Esko, Tõnu; Feitosa, Mary F; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; Fraser, Ross M; Freitag, Daniel F; Gurdasani, Deepti; Heikkilä, Kauko; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne U; Johansson, Asa; Johnson, Toby; Kaakinen, Marika; Kettunen, Johannes; Kleber, Marcus E; Li, Xiaohui; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K E; Mangino, Massimo; Mihailov, Evelin; Montasser, May E; Müller-Nurasyid, Martina; Nolte, Ilja M; O'Connell, Jeffrey R; Palmer, Cameron D; Perola, Markus; Petersen, Ann-Kristin; Sanna, Serena; Saxena, Richa; Service, Susan K; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; Strawbridge, Rona J; Surakka, Ida; Tanaka, Toshiko; Teslovich, Tanya M; Thorleifsson, Gudmar; Van den Herik, Evita G; Voight, Benjamin F; Volcik, Kelly A; Waite, Lindsay L; Wong, Andrew; Wu, Ying; Zhang, Weihua; Absher, Devin; Asiki, Gershim; Barroso, Inês; Been, Latonya F; Bolton, Jennifer L; Bonnycastle, Lori L; Brambilla, Paolo; Burnett, Mary S; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S F; Döring, Angela; Elliott, Paul; Epstein, Stephen E; Eyjolfsson, Gudmundur Ingi; Gigante, Bruna; Goodarzi, Mark O; Grallert, Harald; Gravito, Martha L; Groves, Christopher J; Hallmans, Göran; Hartikainen, Anna-Liisa; Hayward, Caroline; Hernandez, Dena; Hicks, Andrew A; Holm, Hilma; Hung, Yi-Jen; Illig, Thomas; Jones, Michelle R; Kaleebu, Pontiano; Kastelein, John J P; Khaw, Kay-Tee; Kim, Eric; Klopp, Norman; Komulainen, Pirjo; Kumari, Meena; Langenberg, Claudia; Lehtimäki, Terho; Lin, Shih-Yi; Lindström, Jaana; Loos, Ruth J F; Mach, François; McArdle, Wendy L; Meisinger, Christa; Mitchell, Braxton D; Müller, Gabrielle; Nagaraja, Ramaiah; Narisu, Narisu; Nieminen, Tuomo V M; Nsubuga, Rebecca N; Olafsson, Isleifur; Ong, Ken K; Palotie, Aarno; Papamarkou, Theodore; Pomilla, Cristina; Pouta, Anneli; Rader, Daniel J; Reilly, Muredach P; Ridker, Paul M; Rivadeneira, Fernando; Rudan, Igor; Ruokonen, Aimo; Samani, Nilesh; Scharnagl, Hubert; Seeley, Janet; Silander, Kaisa; Stancáková, Alena; Stirrups, Kathleen; Swift, Amy J; Tiret, Laurence; Uitterlinden, Andre G; van Pelt, L Joost; Vedantam, Sailaja; Wainwright, Nicholas; Wijmenga, Cisca; Wild, Sarah H; Willemsen, Gonneke; Wilsgaard, Tom; Wilson, James F; Young, Elizabeth H; Zhao, Jing Hua; Adair, Linda S; Arveiler, Dominique; Assimes, Themistocles L; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Boehm, Bernhard O; Boomsma, Dorret I; Borecki, Ingrid B; Bornstein, Stefan R; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C; Chen, Yii-Der Ida; Collins, Francis S; Cooper, Richard S; Danesh, John; Dedoussis, George; de Faire, Ulf; Feranil, Alan B; Ferrières, Jean; Ferrucci, Luigi; Freimer, Nelson B; Gieger, Christian; Groop, Leif C; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B; Hingorani, Aroon; Hirschhorn, Joel N; Hofman, Albert; Hovingh, G Kees; Hsiung, Chao Agnes; Humphries, Steve E; Hunt, Steven C; Hveem, Kristian; Iribarren, Carlos; Järvelin, Marjo-Riitta; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Kesäniemi, Antero; Kivimaki, Mika; Kooner, Jaspal S; Koudstaal, Peter J; Krauss, Ronald M; Kuh, Diana; Kuusisto, Johanna; Kyvik, Kirsten O; Laakso, Markku; Lakka, Timo A; Lind, Lars; Lindgren, Cecilia M; Martin, Nicholas G; März, Winfried; McCarthy, Mark I; McKenzie, Colin A; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; Morris, Andrew D; Munroe, Patricia B; Njølstad, Inger; Pedersen, Nancy L; Power, Chris; Pramstaller, Peter P; Price, Jackie F; Psaty, Bruce M; Quertermous, Thomas; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; Sanghera, Dharambir K; Saramies, Jouko; Schwarz, Peter E H; Sheu, Wayne H-H; Shuldiner, Alan R; Siegbahn, Agneta; Spector, Tim D; Stefansson, Kari; Strachan, David P; Tayo, Bamidele O; Tremoli, Elena; Tuomilehto, Jaakko; Uusitupa, Matti; van Duijn, Cornelia M; Vollenweider, Peter; Wallentin, Lars; Wareham, Nicholas J; Whitfield, John B; Wolffenbuttel, Bruce H R; Ordovas, Jose M; Boerwinkle, Eric; Palmer, Colin N A; Thorsteinsdottir, Unnur; Chasman, Daniel I; Rotter, Jerome I; Franks, Paul W; Ripatti, Samuli; Cupples, L Adrienne; Sandhu, Manjinder S; Rich, Stephen S; Boehnke, Michael; Deloukas, Panos; Kathiresan, Sekar; Mohlke, Karen L; Ingelsson, Erik; Abecasis, Gonçalo R

    2013-01-01

    Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individual

  6. Control of lipid oxidation at the mitochondrial level

    DEFF Research Database (Denmark)

    Sahlin, Kent

    2009-01-01

    , but the mechanisms regulating fuel preferences remain unclear. During intense exercise, oxidation of long-chain fatty acids (LCFAs) decreases, and the major control is likely to be at the mitochondrial level. Potential mitochondrial sites for control of lipid oxidation include transport of LCFAs into mitochondrial...

  7. Discovery and refinement of loci associated with lipid levels

    NARCIS (Netherlands)

    Willer, Cristen J; Schmidt, Ellen M; Sengupta, Sebanti; Peloso, Gina M; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; Buchkovich, Martin L; Mora, Samia; Beckmann, Jacques S; Bragg-Gresham, Jennifer L; Chang, Hsing-Yi; Demirkan, Ayşe; Den Hertog, Heleen M; Do, Ron; Donnelly, Louise A; Ehret, Georg B; Esko, Tõnu; Feitosa, Mary F; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; Fraser, Ross M; Freitag, Daniel F; Gurdasani, Deepti; Heikkilä, Kauko; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne U; Johansson, Asa; Johnson, Toby; Kaakinen, Marika; Kettunen, Johannes; Kleber, Marcus E; Li, Xiaohui; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Magnusson, Patrik K E; Mangino, Massimo; Mihailov, Evelin; Montasser, May E; Müller-Nurasyid, Martina; Nolte, Ilja M; O'Connell, Jeffrey R; Palmer, Cameron D; Perola, Markus; Petersen, Ann-Kristin; Sanna, Serena; Saxena, Richa; Service, Susan K; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; Strawbridge, Rona J; Surakka, Ida; Tanaka, Toshiko; Teslovich, Tanya M; Thorleifsson, Gudmar; Van den Herik, Evita G; Voight, Benjamin F; Volcik, Kelly A; Waite, Lindsay L; Wong, Andrew; Wu, Ying; Zhang, Weihua; Absher, Devin; Asiki, Gershim; Barroso, Inês; Been, Latonya F; Bolton, Jennifer L; Bonnycastle, Lori L; Brambilla, Paolo; Burnett, Mary S; Cesana, Giancarlo; Dimitriou, Maria; Doney, Alex S F; Döring, Angela; Elliott, Paul; Epstein, Stephen E; Eyjolfsson, Gudmundur Ingi; Gigante, Bruna; Goodarzi, Mark O; Grallert, Harald; Gravito, Martha L; Groves, Christopher J; Hallmans, Göran; Hartikainen, Anna-Liisa; Hayward, Caroline; Hernandez, Dena; Hicks, Andrew A; Holm, Hilma; Hung, Yi-Jen; Illig, Thomas; Jones, Michelle R; Kaleebu, Pontiano; Kastelein, John J P; Khaw, Kay-Tee; Kim, Eric; Klopp, Norman; Komulainen, Pirjo; Kumari, Meena; Langenberg, Claudia; Lehtimäki, Terho; Lin, Shih-Yi; Lindström, Jaana; Loos, Ruth J F; Mach, François; McArdle, Wendy L; Meisinger, Christa; Mitchell, Braxton D; Müller, Gabrielle; Nagaraja, Ramaiah; Narisu, Narisu; Nieminen, Tuomo V M; Nsubuga, Rebecca N; Olafsson, Isleifur; Ong, Ken K; Palotie, Aarno; Papamarkou, Theodore; Pomilla, Cristina; Pouta, Anneli; Rader, Daniel J; Reilly, Muredach P; Ridker, Paul M; Rivadeneira, Fernando; Rudan, Igor; Ruokonen, Aimo; Samani, Nilesh; Scharnagl, Hubert; Seeley, Janet; Silander, Kaisa; Stancáková, Alena; Stirrups, Kathleen; Swift, Amy J; Tiret, Laurence; Uitterlinden, Andre G; van Pelt, L Joost; Vedantam, Sailaja; Wainwright, Nicholas; Wijmenga, Cisca; Wild, Sarah H; Willemsen, Gonneke; Wilsgaard, Tom; Wilson, James F; Young, Elizabeth H; Zhao, Jing Hua; Adair, Linda S; Arveiler, Dominique; Assimes, Themistocles L; Bandinelli, Stefania; Bennett, Franklyn; Bochud, Murielle; Boehm, Bernhard O; Boomsma, Dorret I; Borecki, Ingrid B; Bornstein, Stefan R; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; Chambers, John C; Chen, Yii-Der Ida; Collins, Francis S; Cooper, Richard S; Danesh, John; Dedoussis, George; de Faire, Ulf; Feranil, Alan B; Ferrières, Jean; Ferrucci, Luigi; Freimer, Nelson B; Gieger, Christian; Groop, Leif C; Gudnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; Harris, Tamara B; Hingorani, Aroon; Hirschhorn, Joel N; Hofman, Albert; Hovingh, G Kees; Hsiung, Chao Agnes; Humphries, Steve E; Hunt, Steven C; Hveem, Kristian; Iribarren, Carlos; Järvelin, Marjo-Riitta; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Kesäniemi, Antero; Kivimaki, Mika; Kooner, Jaspal S; Koudstaal, Peter J; Krauss, Ronald M; Kuh, Diana; Kuusisto, Johanna; Kyvik, Kirsten O; Laakso, Markku; Lakka, Timo A; Lind, Lars; Lindgren, Cecilia M; Martin, Nicholas G; März, Winfried; McCarthy, Mark I; McKenzie, Colin A; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; Morris, Andrew D; Munroe, Patricia B; Njølstad, Inger; Pedersen, Nancy L; Power, Chris; Pramstaller, Peter P; Price, Jackie F; Psaty, Bruce M; Quertermous, Thomas; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; Sanghera, Dharambir K; Saramies, Jouko; Schwarz, Peter E H; Sheu, Wayne H-H; Shuldiner, Alan R; Siegbahn, Agneta; Spector, Tim D; Stefansson, Kari; Strachan, David P; Tayo, Bamidele O; Tremoli, Elena; Tuomilehto, Jaakko; Uusitupa, Matti; van Duijn, Cornelia M; Vollenweider, Peter; Wallentin, Lars; Wareham, Nicholas J; Whitfield, John B; Wolffenbuttel, Bruce H R; Ordovas, Jose M; Boerwinkle, Eric; Palmer, Colin N A; Thorsteinsdottir, Unnur; Chasman, Daniel I; Rotter, Jerome I; Franks, Paul W; Ripatti, Samuli; Cupples, L Adrienne; Sandhu, Manjinder S; Rich, Stephen S; Boehnke, Michael; Deloukas, Panos; Kathiresan, Sekar; Mohlke, Karen L; Ingelsson, Erik; Abecasis, Gonçalo R

    2013-01-01

    Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577

  8. Discovery and refinement of loci associated with lipid levels

    DEFF Research Database (Denmark)

    Willer, C. J.; Schmidt, E. M.; Sengupta, S.

    2013-01-01

    Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individ...

  9. 2型糖尿病患者血脂和蛋白水平对血糖控制程度的影响%Effect of Serum Lipids and Protein Levels on Blood Glucose Control in Type 2 Diabetic Patients

    Institute of Scientific and Technical Information of China (English)

    秦蕾; 杨旭; 张亚文

    2015-01-01

    Objective To observe the effect of serum lipids and protein levels on blood glucose control in patients with type 2 diabetes mellitus. Methods 110 cases with type 2 diabetes were chosen from January 2014 to March 2015 as the observation group, the health examination in the same period in 80 cases as the control group, compared and analyzed gycosylated hemoglobin, blood glucose and blood lipids. Results The FDG, TG, TC, HbA1c, LDL-C in the observation group were significantly higher than those in the control group (P<0.05), and HDL-C was significantly lower than that in the control group (P<0.05), the difference was statistically significant. Conclusion The metabolic disorders of lipid and protein in T2DM patients, and the monitoring of serum lipid and protein levels in T2DM patients have certain reference value to the disease and treatment effect.%目的:观察血脂和蛋白水平对2型糖尿病患者血糖控制程度的影响。方法选取2014年1月~2015年3月治疗的2型糖尿病患者110例作为观察组,同期健康体检者80例作为对照组,检测其糖化血红蛋白、血糖、血脂水平并进行对比分析。结果观察组FDG、TC、TG、HbA1c、LDL-C高于对照组(P<0.05),HDL-C低于对照组(P<0.05),差异具有统计学意义。结论T2DM患者存在脂肪和蛋白质的代谢紊乱,T2DM患者血脂和蛋白水平的监测对其病情和治疗效果的判定有一定参考价值。

  10. [The characteristics of tissue lipid peroxidation in the internal organs and the lipid metabolic indices of the blood plasma in a low geomagnetic field].

    Science.gov (United States)

    Babych, V I

    1995-01-01

    It was found in experiments on guinea-pigs and white rats that 100-time weakened magnetic field of the earth considerably increased the activity of peroxide oxidation of lipids (POL) in tissues of inner organs. In the lungs, liver, kidneys, small intestine under the influence of hypogeomagnetic field (HGMF) we have observed reduction of ferment antioxidizing activity and of non-ferment mechanisms in the heart. The process is accompanied by reduction of cholesterol, phospholipids and triglycerides in guinea-pigs and increase of this indices in white rats after 5-day-long stay of animals in the hypogeomagnetic chamber. The data of experiments on white rats underlie a conclusion that the 5-day-long influence of HGMF promotes the change of the carbohydrate metabolism for lipid metabolism. The reaction of guinea-pigs on the stay under the weakened magnetic field of the earth displays in reduction of the level of lipid metabolism indices in the blood serum.

  11. Association between Chronic Periodontitis and Serum Lipid Levels

    Directory of Open Access Journals (Sweden)

    Ferial Taleghani

    2010-02-01

    Full Text Available Regarding the high prevalence of hyperlipidaemia, which is one of the major risk factors of cardiovascular disease, and uncertain reports about the relation between periodontal disease and serum lipid profile, this study was conducted to assess this relation. The historical cohort study was conducted on 52 cases including 26 persons with chronic periodontitis as case group, and 26 healthy subjects as control group. Both groups had the same age and weight ranges, sex, and diet, without any periodontal treatment history in the past six months, underling systemic disease such as diabetes, anti-hyperlipidemic drugs or active tobacco smoking history. Low Density Lipoprotein (LDL, High Density Lipoprotein (HDL, Triglyceride (TG and Total Cholesterol (CHOL were measured by direct enzymatic assay. TG level was 128.4±71.1 mg/dl in control group and 165.2± 83.7 in case group indicating a significantly higher level in case group (P<0.05. In control group, 30.8 percent and in case group, 61.5 percent had abnormal serum cholesterol levels, which presents a significantly higher level in case group (P<0.03. Other serum level indices did not show any significant difference. Although it seems that patients with chronic periodontal disease are more susceptible to hyperlipidemia, it is doubtful that the former causes an increase in serum lipid levels, so we suggest studying the effects of treating chronic periodontitis on serum lipid level.

  12. Levels of oxidative damage and lipid peroxidation in thyroid neoplasia.

    LENUS (Irish Health Repository)

    Young, Orla

    2012-02-01

    BACKGROUND: This study assessed the presence of oxidative damage and lipid peroxidation in thyroid neoplasia. METHODS: Using tissue microarrays and immunohistochemistry, we assessed levels of DNA damage (8-oxo-dG) and lipid peroxidation (4-HNE) in 71 follicular thyroid adenoma (FTA), 45 papillary thyroid carcinoma (PTC), and 17 follicular thyroid carcinoma (FTC) and matched normal thyroid tissue. RESULTS: Cytoplasmic 8-oxo-dG and 4-HNE expression was significantly higher in FTA, FTC, and PTC tissue compared to matched normal tissue (all p values < .001). Similarly, elevated nuclear levels of 8-oxo-dG were seen in all in FTA, FTC, and PTC tissue compared to matched normal (p values < .07, < .001, < .001, respectively). In contrast, a higher level of 4-HNE expression was detected in normal thyroid tissue compared with matched tumor tissue (p < .001 for all groups). Comparing all 3 groups, 4-HNE levels were higher than 8-oxo-dG levels (p < .001 for all groups) except that cytoplasmic levels of 8-oxo-dG were higher than 4-HNE in all (p < .001). These results were independent of proliferation status. CONCLUSION: High levels of DNA damage and lipid peroxidation in benign and malignant thyroid neoplasia indicates this damage is an early event that may influence disease progression.

  13. To Study Correlation of Body Fat and Blood Lipids with Autonomic ...

    African Journals Online (AJOL)

    To Study Correlation of Body Fat and Blood Lipids with Autonomic Nervous System ... Subjects and Methods: A total of 60 PM sedentary women without any gross ... Multiple regression analysis revealed LDL cholesterol as the only significant ...

  14. Stability and Reliability of Plasma Level of Lipid Biomarkers and Their Correlation with Dietary Fat Intake

    Directory of Open Access Journals (Sweden)

    Sang-Ah Lee

    2008-01-01

    Full Text Available The reliability and stability of plasma lipid biomarkers and their association with dietary fat intake were evaluated among 48 subjects who were randomly chosen from the participants of a validation study of the population-based cohort, the Shanghai Men's Health Study (SMHS. Four spot blood samples, one taken each season, were measured for total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol levels. The reliability and stability of these measurements were assessed by intraclass correlation coefficients (ICC and by the correlations between a randomly chosen measurement with the mean of measurements across seasons using a bootstrap approach. The median levels for total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol were 177.5, 164.5, 41.0, and 102.5 (mg/dl, respectively. The ICCs of the biomarkers ranged from 0.58 (LDL-cholesterol to 0.83 (HDL-cholesterol. The correlation between randomly chosen spot measurements and the mean measurement were 0.91, 0.86, 0.93, and 0.83 for total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol, respectively. The correlations of lipid biomarkers with dietary fat intake and other lifestyle factors were comparable to other previous reports. In conclusion, this study suggests that measurements of lipid biomarkers from a single spot blood sample are a good representation of the average blood levels of these biomarkers in the study population and could be a useful tool for epidemiological studies.

  15. Physicians' Lack of Adherence to National Heart, Lung, and Blood Institute Guidelines for Pediatric Lipid Screening.

    Science.gov (United States)

    Valle, Christopher W; Binns, Helen J; Quadri-Sheriff, Maheen; Benuck, Irwin; Patel, Angira

    2015-10-01

    To determine adherence to the 2011 National Heart, Lung, and Blood Institute lipid screening guidelines and identify patient factors promoting screening. Records of children who received well-child care at age 11 years and turned 12 in 2013 were reviewed. Subjects were stratified by guideline-defined dyslipidemia risk based on documented medical or family history risk factors. We defined adherence as the order of a lipid profile when age 11 years or completed lipid screening at 9 to 10 years. Of 298 subjects, 42% were assigned to the dyslipidemia high-risk subgroup. Records of 27.2% demonstrated adherence. Fifty-six percent of high-risk subjects versus 6% of their non-high-risk counterparts received lipid screening by age 12 (P obesity and parental history of dyslipidemia were significantly associated with lipid testing. Lipid screening rates were low. Strategies to increase lipid screening in the primary care setting are needed. © The Author(s) 2015.

  16. Effect of Tamarindus indica fruits on blood pressure and lipid-profile in human model: an in vivo approach.

    Science.gov (United States)

    Iftekhar, A S M Maruf; Rayhan, Israt; Quadir, Mohiuddin Abdul; Akhteruzzaman, Sharif; Hasnat, Abul

    2006-04-01

    Fruits of Tamarindus indica were evaluated for their effects on lipid profile, systolic and diastolic blood pressure and body weight in human subjects. Dried and pulverized pulp of T. indica fruits, at a dose of 15 mg/kg body weight, was found to reduce total cholesterol level (p = 0.031) and LDL-cholesterol level (p = 0.004) to a significant extent. Though the fruits exerted no conspicuous effect on body weight and systolic blood pressure, it significantly reduced the diastolic pressure as confirmed by independent sample t-test at 5% significance level.

  17. Comparison of Cord Blood Lipid Profile in Preterm Small for Gestational Age and Appropriate for Gestational Age Newborns

    Science.gov (United States)

    Katragadda, Tejasree; Shetty, Subodh; Baliga, Shantharam

    2017-01-01

    Introduction Coronary heart disease is one of the major causes of morbidity and mortality in current era. The roots of this epidemic have been traced to as early as foetal life by foetal origin hypothesis. There are a few studies which have compared the cord blood lipid profile of preterm and term babies and thereby leading a path to primordial prevention of chronic diseases. Aim To study cord blood lipid profile of preterm appropriate for gestational age and preterm small for gestational age neonates and compare atherogenic index of both groups. Materials and Methods This cross-sectional study was conducted in 109 preterm infants. Cord blood samples were collected from placental side of umbilical cord at birth and analyzed for lipid profile which includes serum cholesterol, triglycerides, Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and apolipoproteins which include ApoA1, Apo B. Results Preterm Small for Gestational Age (SGA) neonates had statistically significant higher values of triglycerides, Apo B and atherogenic index compared to preterm Appropriate for Gestational Age (AGA) neonates. Other measured lipid levels were not statistically significant, though the values were higher than reference ranges for term babies. Conclusion Prematurity as a factor associated with a more atherogenic lipid profile is re-affirmed and SGA as an additional risk factor has been proven giving scope for future research and primordial prevention.

  18. The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children.

    Science.gov (United States)

    Zou, Zhi-Yong; Yang, Yi-de; Wang, Shuo; Dong, Bin; Li, Xiao-Hui; Ma, Jun

    2016-07-01

    We aimed to examine the contribution of blood lipids to the association between BMI and blood pressure (BP) in children with overweight and obesity. Data were collected in elementary and high schools of Chaoyang District, Beijing, China in 2012. Participants' weight, height, BP and fasting plasma lipid profile were measured by standard protocols. Mediation analysis was used to examine the mediation role of blood lipids on the relation between BMI and BP, with age included as a covariate. We found that in boys 8·29 % (mediation effect=0·106, P=0·012) of the association between BMI and systolic BP was mediated through TAG. TAG mediated 12·53 % (mediation effect=0·093, P=0·018) and LDL-cholesterol mediated 7·75 % (mediation effect=0·57, P=0·046) of the association between BMI and diastolic BP was mediated by TAG and LDL-cholesterol, respectively. However, blood lipids did not show the mediation effect in girls. Our findings suggested that there was a sex difference in the contribution of blood lipids to the association between BMI and BP. Controlling TAG or LDL-cholesterol may be beneficial for reducing the risk of the BMI-related high BP in overweight boys; however, this outcome is not the case when controlling TAG or LDL-cholesterol in girls. This study may provide clues to explore the underlying mechanism of the association between obesity and hypertension.

  19. Effects of Zinc Supplementation on the Anthropometric Measurements, Lipid Profiles and Fasting Blood Glucose in the Healthy Obese Adults

    Directory of Open Access Journals (Sweden)

    Sepide Mahluji

    2013-02-01

    Full Text Available Purpose: The aim of this study was to assess the effects of zinc supplementation on anthropometric measures, improving lipid profile biomarkers, and fasting blood glucose level in obese people. Methods: This randomized, double- blind clinical trial was carried out on 60 obese participants in the 18-45 age range for one month. The participants were randomly divided into the intervention group, who received 30 mg/d zinc gluconate, and the placebo group who received 30mg/d starch. Anthropometric measurements (body mass index (BMI, weight and waist circumference were recorded before and at the end of study. Lipid profile biomarkers and fasting blood glucose were determined using enzymatic procedure. Analysis of Covariance (ANCOVA test was run to compare the post-treatment values of the two groups, and t-test was conducted to compare within group changes. Results: Serum zinc concentration was increased significantly in intervention group (p=0.024. BMI and body weight was significantly decreased (p=0.030 and p=0.020, respectively. Lipid profile biomarkers and fating blood glucose did not change significantly but triglyceride level was significantly decreased (p=0.006 in the intervention group. Conclusion: The obtained results indicate that zinc supplementation improves BMI, body weight, and triglyceride concentration without considerable effects on lipid profile and glucose level. Zinc can be suggested as a suitable supplementation therapy for obese people, but more studies are needed to verify the results.

  20. Measurement Challenges at Low Blood Lead Levels.

    Science.gov (United States)

    Caldwell, Kathleen L; Cheng, Po-Yung; Jarrett, Jeffery M; Makhmudov, Amir; Vance, Kathryn; Ward, Cynthia D; Jones, Robert L; Mortensen, Mary E

    2017-08-01

    In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is calculated as the 97.5th percentile of the distribution of blood lead levels (BLLs) in children 1 to 5 years old from 2007 to 2010 NHANES data. We calculated and updated selected percentiles, including the 97.5th percentile, by using NHANES 2011 to 2014 blood lead data and examined demographic characteristics of children whose blood lead was ≥90th percentile value. The 97.5th percentile BLL of 3.48 µg/dL highlighted analytical laboratory and clinical interpretation challenges of blood lead measurements ≤5 μg/dL. Review of 5 years of results for target blood lead values Lead and Multi-Element Proficiency quality assurance program showed 40% unable to quantify and reported a nondetectable result at a target blood lead value of 1.48 µg/dL, compared with 5.5% at a target BLL of 4.60 µg/dL. We describe actions taken at the CDC's Environmental Health Laboratory in the National Center for Environmental Health, which measures blood lead for NHANES, to improve analytical accuracy and precision and to reduce external lead contamination during blood collection and analysis. Copyright © 2017 by the American Academy of Pediatrics.

  1. The relationship between serum resistin level and blood sugar, blood lipids and thyroid hormone in patients with hyperthyroidism%甲状腺功能亢进症患者血清抵抗素水平与血糖、血脂及甲状腺激素的关系

    Institute of Scientific and Technical Information of China (English)

    常玉莹; 孙玉倩

    2011-01-01

    Objective To undertake a controlled, prospective study to investigate the relationship between serum resistin level and blood sugar, blood lipids and thyroid hormone in patients with hyperthyroidism. Methods Clinical data of 50 patients with hyperthyriodism were collected from 2008 to 2009 in department of endocrinology the Second Hospital of Harbin Medical University. All patients were newly diagnosed cases that received no medication. At the same time, 40 healthy persons underwent physical examination in the hospital were taken as control group. Diabetes, obesity, hypertension, and high cholesterol were excluded from the two groups. Serum resistin level was determined using ELISA method. Chemiluminescence was used to check the levels of fasting insulin, free triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone (TSH). Glucose oxidase method determination-peroxidase-anti-peroxidase(GOD-PAP) was used to check the levels of fasting blood-glucose.Cholesterol oxidase method was used to check the levels of total cholesterol(T-CH). Glycerol-phosphate oxidase was used to check the levels of triglyceride(TG). Enzymes colorimetric method was used to check high density level of lipoprotein cholesterol(HDL-C) and low density level of lipoprotein cholesterol (LDL-C), and the height, weight,waist circumference, and hip circumference were measured. Body mass index (BMI) and insulin resistance index (HOMA-IR) were calculated. Groups were compared using t test and correlation analysis using Pearson correlation test, and the relationship between serum resistin level and blood sugar, blood lipids and thyroid hormone were analyzed using multiple linear stepwise regression analysis method. Results Serum glucose[(5.2 ± 0.7)mmol/L],resistin concentrations[(132.1 ± 41.3)μg/L], FT3[(19.8 ± 8.7) pmol/L], FT4[(54.1± 29.6)pmol/L], fasting insulin levels[(7.9 ± 2.8)mU/L] and HOMA-IR(2.3 ± 1.0) were significantly higher compared with controls group [(4.7 ± 0

  2. A comparison of the effect of free access to reduced fat products or their full fat equivalents on food intake, body weight, blood lipids and fat-soluble antioxidants levels and haemostasis variables

    NARCIS (Netherlands)

    Weststrate, J.A.; Hof, K.H. van het; Berg, H. van den; Velthuis-te-Wierik, E.J.M. te; Graaf, C. de; Zimmermanns, N.J.H.; Westerterp, K.R.; Westerterp-Plantenga, M.S.; Verboeket-Venne, W.P.H.G. van de

    1998-01-01

    Objectives: To compare the effects of free access to reduced fat products or their full fat equivalents on fat and energy intake, body weight, plasma lipids and fat-soluble antioxidants concentrations and haemostasis variables. Design: A multicentre open randomised controlled trial in which

  3. Tear film lipid layer: A molecular level view.

    Science.gov (United States)

    Cwiklik, Lukasz

    2016-10-01

    Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear film and helps with the film re-spreading after blinks. Alterations of tear lipids composition and properties are related to dry eye syndrome. Therefore, unveiling structural and functional properties of TFLL is necessary for understanding tear film function under both normal and pathological conditions. Key properties of TFLL, such as resistance against high lateral pressures and ability to spread at the tear film surface, are directly related to the chemical identity of TFLL lipids. Hence, a molecular-level description is required to get better insight into TFLL properties. Molecular dynamics simulations are particularly well suited for this task and they were recently used for investigating TFLL. The present review discusses molecular level organization and properties of TFLL as seen by these simulation studies. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

  4. The relationship between dietary glycemic load and levels of blood glucose and lipid in patients with newlydiagnosed type 2 diabetes%新诊断2型糖尿病患者膳食血糖负荷与血糖、血脂的关系

    Institute of Scientific and Technical Information of China (English)

    林秀红; 陈超刚; 林刁珠; 袁智敏; 何凤怡; 徐明彤; 严励

    2014-01-01

    To discuss the relationship between dietary glycemic load (GL) and blood glucose and lipid,201 patients with newly-diagnosed type 2 diabetes and 126 subjects with normal glucose tolerance were enrolled,who were all above 40 years old and permanently lived in communities of Guangzhou.GL,blood glucose and lipid were assessed based on 3-d dietary records.The results showed that the level of dietary glycemic load in diabetic patients was significantly higher than control group (169.61 ± 44.83 vs 157.50 ± 38.47,P<0.05).Correlation analysis showed that dietary GL was positively correlated with body mass index and HbA1C,and negatively correlated with HDL-C in diabetic patients (all P<0.05).Adjusted for age and sex by multiple regression,the result was the same.Therefore,dietary with high level of GL may be associated with the occurrence of type 2 diabetes,and is closely related to glucose control and blood lipid metabolism suggesting the necessity to control the level of dietary GL in the nutritional therapy for diabetic patients.%为探讨膳食血糖负荷(glycemic load,GL)水平与血糖、血脂的关系,收集了常住广州某社区40岁以上的新诊断2型糖尿病患者201例及血糖正常对照者126名,统计3d的膳食,分析比较两组的膳食GL水平和血糖、血脂状况.结果表明新诊断糖尿病组膳食GL较血糖正常对照者显著升高(169.61±44.83对157.50±38.47,P<0.05),且与体重指数、HbA1C呈显著正相关,与高密度脂蛋白胆固醇呈显著负相关(均P<0.05).高GL膳食可能与2型糖尿病的发生风险相关,且与血糖控制及血脂关系密切,有必要在糖尿病患者的饮食治疗中控制膳食GL水平.

  5. 不同程度高三酰甘油血症患者的生化指标比较%The comparison on anthropometric measurements and blood lipid levels among patients with different degrees of hypertriglyceridemia with different triglyceride levels

    Institute of Scientific and Technical Information of China (English)

    景洪江; 张荣欣; 张月红; 刘英华; 薛长勇

    2011-01-01

    Objective To compare the anthropometric indexces and lipid metabolism among hypertriglyceri-demia subjects with different blood triglyceride ( TG) levels. Methods 101 subjects with hypertriglyceridemia were chosen to this study. The anthropometric measurements of body height, weight, body mass index ( BMI), waist circumference (WC) ,blood TG, total cholesterol( TC) , high-density and low-density lipoprotein cholesterol ( HDL-C, LDL-C) ,apolipoprotein A1 ,B>A2 ,C2 ,C3 ,E( ApoA1 ,B,A2 ,C2 ,C3 ,E) were measured. Then all subjects were divided into two groups according to 1.70 mmol/L≤TG≤2.25 nunol/L and TG≥2. 26 mmol/L,compare the indices mentioned above between the two groups. Results The enrolled subjects of the two groups were overweight according to BMI, and abdominal obesity according to WC. In the group with TG≥2.26mmol/L,the contents of blood TG,Apo E,C2, C3 ,A II were significantly higher than those in the group with 1. 70mmol/L≤TG≤2. 25mmol/L(P <0. 01 or P < 0.05), while no other significant difference were observed between the two groups. Conclusion The blood ApoE, C2, C3, A2 among hypertriglyceridemia subjects were concomitant with levels of TG and thus provide some helpful parameters to evaluate the severity of hypertriglyceridemia.%目的 对不同程度的高三酰甘油血症患者的人体测量及血脂生化指标进行比较分析.方法 选择高三酰甘油血症患者101例,取空腹血测定血三酰甘油(trG)、总胆固醇(TC)、高密度及低密度脂蛋白胆固醇( HDL-C、LDL-C)、载脂蛋白A1、B、A2、C2、C3、E( ApoA1、B、A2、C2、C3、E)等指标,并进行身高、体质量、腰围等人体测量,计算体质量指数( BMI),按1.70 mmol/L≤TG≤2.25 mmol/L和TG≥2.26 mmoL/L将研究对象分为临界高脂组和高脂血症组,比较两组人群上述人体测量及血脂生化指标的差异.结果 两组人群的BMI处于超重水平,从腰围判断属于腹型肥胖;高脂血症组人群的血TG、ApoE、C2

  6. Umbilical cord blood mercury levels in China

    Institute of Scientific and Technical Information of China (English)

    Meiqin Wu,; Chonghuai Yan; Jian Xu; Wei Wu; Hui Li; Xin Zhou

    2013-01-01

    Mercury (Hg) is a well-known neurotoxicant.Hg exposure at high levels can harm individuals of all ages.Even low level exposure to Hg can damage the brain of fetuses and young children,and affect their central nervous system and cognitive development.The aims of our study were to measure total Hg levels in infant umbilical cord blood and to investigate the risk factors associated with total Hg cord blood levels in various cities in China.Our goal was to provide clues for the prevention of Hg exposure in utero.The results indicated that the average cord blood mercury levels (CBMLs) were (1.81 ± 1.93) μg/L,which were lower than those found in most previous studies.The concentrations also differed according to geographic region.The CBMLs were not only associated with family economic and living conditions,but also with diet in pregnant women,especially the intake of marine fish,shellfish,poultry,formula milk and fruits.

  7. The associations of a marine diet with plasma lipids, blood glucose, blood pressure and obesity among the inuit in Greenland

    DEFF Research Database (Denmark)

    Bjerregaard, P; Pedersen, H S; Mulvad, G

    2000-01-01

    OBJECTIVE: To analyse the associations between the intake of fish and marine mammals and risk factors for cardiovascular disease, ie lipid profile, fasting blood glucose, blood pressure and obesity, in a population whose average consumption of n-3 fatty acids is high compared with Western countries...... was positively associated with serum high-density lipoprotein (HDL) and blood glucose and inversely with very-low-density lipoprotein (VLDL) and triglyceride. Association with low-density lipoprotein (LDL), diastolic and systolic blood pressure, waist-hip ratio and body mass index were inconsistent...... and not statistically significant. The pattern was similar within groups with low, medium and high consumption of marine food. CONCLUSIONS: There are statistically significant associations between the consumption of marine food and certain lipid fractions in the blood also in this population with a very high average...

  8. Relação da cintura abdominal com a condição nutricional, perfil lipídico e pressão arterial em pré-escolares de baixo estrato socioeconômico Relationship between waist circumference and nutritional status, lipid profile and blood pressure in low socioeconomic level pre-school children

    Directory of Open Access Journals (Sweden)

    Roseli Saccardo Sarni

    2006-08-01

    Full Text Available OBJETIVO: Avaliar o diagnóstico nutricional, o perfil lipídico, os níveis pressóricos e a medida de cintura em pré-escolares. Pretende-se ainda verificar se a medida de cintura está associada com índices antropométricos usuais no diagnóstico nutricional, perfil lipídico e pressão arterial em crianças obesas e eutróficas. MÉTODOS: Estudo transversal realizado com 65 pré-escolares de baixo estrato socioeconômico, em escola municipal de Santo André. As avaliações clínico-laboratoriais consistiram em: medida de PA (Task Force, 1996, peso (P e estatura (E expressos como escore z (OMS, 1995 e IMC (índice de massa corpórea; níveis séricos de triglicérides, colesterol total e frações (VLDL-c, HDL-c, LDL-c (Kwiterowich e AHA. Análise estatística: Teste exato de Fisher e correlação. RESULTADOS: Observamos alto porcentual de inadequação da PA e lipídios séricos, independentemente da condição nutricional. A medida de cintura mostrou correlação positiva e significante com IMC e ZPE (r = 0,87 e r = 0,83; p OBJECTIVE: To evaluate anthropometric data, blood lipid levels, blood pressure (BP and waist circumference (WC in preschool children. To relate WC with blood lipid levels and BP in obese and non-obese children. METHODS: In a transversal study we investigated 65 preschool children of low socioeconomic level in Santo André, São Paulo. The evaluation consisted of BP measurement (Task Force, 1996, weight (W, height (H expressed as z score (WHO,1995 and body mass index (BMI, triglycerides, total and fractions of cholesterol blood levels (Kwiterovich and AHA. Statistical analysis: Fisher test and correlations. RESULTS: We observed high BP and lipid levels unrelated to nutritional status. WC was significantly and positively correlated to BMI and ZWH (r = 0,87 and r = 0,83, respectively. Using as a cut-off 75 percentile of WC we found an accuracy of 89,1% with 87,2% specificity and 70,6% sensitivity and predictive value

  9. Lacto-Vegetarian Diet and Correlation of Fasting Blood Sugar with Lipids in Population Practicing Sedentary Lifestyle.

    Science.gov (United States)

    Praharaj, Ardhendu Bhusan; Goenka, Ramesh Kumar; Dixit, Sujata; Gupta, Manoj Kumar; Kar, Shantanu Kumar; Negi, Sapna

    2017-09-11

    Rising burden of diabetes in India requires quick intervention that integrates policies and programs for effective prevention and control of disease. This retrospective cross-sectional study was conducted to observe effect of diet in two Indian communities practicing sedentary lifestyle. Fasting blood samples were analyzed for blood sugar, glycated-hemoglobin (HbA1C), and lipid profile. Body mass index (BMI) and waist circumference (WC) measurements were recorded. Diabetes incidence was lower in lacto-vegetarian (1.7%) than in non-vegetarian group (5.3%) despite similar lipid profiles and BMI/WC between the groups. Fasting blood sugar (FBS) was positively correlated with LDL and VLDL levels and negatively correlated with HDL, only in lacto-vegetarian group. Study suggests: (1) Indian lacto-vegetarian diet has beneficial effects on diabetes incidence irrespective of high body weight and sedentary lifestyle; (2) intervention to reduce body lipids, such as lipid-lowering drugs and exercise, may have greater effect in reducing FBS levels in this lacto-vegetarian group.

  10. Association of fasting insulin with serum lipids and blood pressure in Kuwaiti children.

    Science.gov (United States)

    Moussa, M A; Shaltout, A A; Nkansa-Dwamena, D; Mourad, M; Al-Sheikh, N; Agha, N; Galal, D O

    1998-04-01

    To examine the association of hyperinsulinemia with the atherogenic risk profile in children, we studied the relationships of the fasting plasma insulin level with indices of obesity (body mass index [BMI] and sum of triceps and subscapular skinfold thickness [SFT]), body fat distribution (waist to hip ratio [WHR]), serum lipid, lipoprotein, and apolipoprotein levels, and blood pressure in a case-control study of 460 Kuwaiti prepubertal obese children aged 6 to 13 years matched by age and sex to 460 prepubertal non-obese controls. Obese children were ascertained in a representative cross-sectional study of 2,400 school children. Fasting insulin levels were positively correlated (P < .001) with serum triglyceride (TG) and very-low-density lipoprotein (VLDL) cholesterol levels and negatively correlated with high-density lipoprotein (HDL) cholesterol levels. No significant associations were observed between insulin and total cholesterol (TC), cholesterol, low-density lipoprotein (LDL) or apolipoprotein A-I (apo A-I). Stronger associations of insulin levels with lipoprotein fractions were observed in obese versus non-obese controls. Obese children had a higher concentration of apo B and a lower apo A-I:B ratio (P < .001). Insulin and the insulin to glucose ratio increased with age in obese children, whereas there were slight changes in non-obese children. TG and HDL cholesterol levels and systolic blood pressure (SBP) were significantly different across insulin quartiles in boys and girls. We conclude that the fasting plasma insulin level may be used as a marker for the development of obesity-associated metabolic disorders and elevated blood pressure in children.

  11. [Correlations between the pathogenesis and prognosis of sudden sensorineural hearing loss and blood lipid].

    Science.gov (United States)

    Chen, Chengfang; Wang, Mingming; Fan, Zhaomin; Zhang, Daogong; Lyu, Yafeng; Wang, Hongya; Wang, Haibo

    2015-10-01

    We aimed to determine whether blood lipid parameters were related to the severity and the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) patients. A retrospective cohort study of 258 patients with ISSNHL from December 2013 to February 2015. The distribution characteristics of lipids [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Non-high-density lipoprotein cholesterol (Non-HDL-C), et al] in different degree of deafness (mild, moderate, severe, and profound), hearing curve types (low frequency, high frequency, full range frequency, and completely deafness type) and prognosis of recovery (complete, partial, slight, and no recovery) were analyzed by IBM SPSS 22.0 ANOVA analysis, chi square test and multiple regression analysis. TG level in mild hearing loss group was significantly lower than that in severe and profound hearing loss group (P = 0.017 and P = 0.007). There were no correlation between curve types and lipid indexes (P > 0.05). Non-HDL-C level was elevated in no recovery and slight recovery groups (P = 0.026 and 0.021). TC levels in partial recovery group and no recovery group were significantly higher than that in the complete recovery group (P = 0.049 and 0.042), TG was higher in slight recovery group (P = 0.014). TG has significant correlation with the severity of hearing loss. There are negative correlations between hearing recovery and Non-HDL-C, TC and TG levels. Non-HDL-C, TC and TG might be a prognostic factor for treatment outcome in ISSNHL patients.

  12. Effect of atorvastatin on blood lipid indexes of patients with transient ischemic attack

    Institute of Scientific and Technical Information of China (English)

    Gui-Yu Li; Wen-Zhong Wang; Jia-Yan Li

    2015-01-01

    Objective:To investigate the effect of atorvastatin therapy on lipid levels of patients with transient ischemic attack (TIA).Methods:A total of 210 cases of TIA were selected as research subjects, and randomly divided into two groups with 105 cases in each group. Patients in the control group were treated with conventional therapy, and the observation group were treated with conventional treatment based on the use of atorvastatin. Incidence of cerebrovascular diseases, high-density lipoprotein (HDL), low density lipoprotein changes (LDL), triglycerides (TG) and total cholesterol (TC) and side effect of two groups were compared.Results:The incidence of cerebrovascular diseases was 10.48%, and significantly lower than the control group (P<0.05). The levels of HDL after treatment was significantly higher than the control group, and the levels of LDL, TG and TC after treatment were significantly lower than the control group (P<0.05). No adverse reaction occurred in both groups.Conclusion: Atorvastatin is safe and effective in prevention of TIA patients from cerebrovascular events, and can improve blood lipid indexes.

  13. Changes in blood antioxidant status and lipid peroxidation following distance running

    OpenAIRE

    KELLE, Mustafa

    1998-01-01

    To examine the effects of increased O 2 utilization on blood antioxidant status and lipid peroxidation, ten trained male athletes took part in a 20 km distance race. Venous blood samples were removed before and immediately after completion of the half-marathon. Plasma creatine kinase (CK) activity, an index of muscle damage, increased (p

  14. Investigation of endogenous blood lipids components that contribute to matrix effects in dried blood spot samples by liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Ismaiel, Omnia A; Jenkins, Rand G; Karnes, H Thomas

    2013-08-01

    Dried blood spot (DBS) sampling coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a rapidly developing approach in the field of biopharmaceutical analysis. DBS sampling enables analysis of small sample volumes with high sensitivity and selectivity while providing a convenient easy to store and ship format. Lipid components that may be extracted during biological sample processing may result in matrix ionization effects and can significantly affect the precision and accuracy of the results. Glycerophosphocholines (GPChos), cholesterols and triacylglycerols (TAG) are the main lipid components that contribute to matrix effects in LC-MS/MS. Various organic solvents such as methanol, acetonitrile, methyl tertiary butyl ether, ethyl ether, dichloromethane and n-hexane were investigated for elution of these lipid components from DBS samples. Methanol extracts demonstrated the highest levels of GPChos whereas ethyl ether and n-hexane extracts contained less than 1.0 % of the GPChos levels in the methanol extracts. Ethyl ether extracts contained the highest levels of cholesterols and TAG in comparison to other investigated organic solvents. Acetonitrile is recommended as an elution solvent due to low lipid recoveries. Matrix effects resulted from different extracted lipid components should be studied and assessed carefully in DBS samples.

  15. The antagonist activity of lipid IVa on the stimulation by lipid A of TNF-alpha production from canine blood mononuclear cells.

    Science.gov (United States)

    Takasawa, Kenji; Kano, Rui; Maruyama, Haruhiko; Hasegawa, Atsuhiko; Kamata, Hiroshi

    2011-09-15

    Lipid A, the active component of lipopolysaccharide (LPS), exists in the outer membrane of Gram-negative bacteria and binds to the Toll-like receptor 4 (TLR4) and MD-2 complex. On the other hand, the synthetic precursor of Escherichia coli lipid A, tetraacylated lipid IVa, is an agonist for TLR4 and MD-2 complex in murine, equine and feline cells but is an antagonist for lipid A in human cells. The aim of the study was to examine the function of canine Toll-like receptor 4 (TLR4) and MD-2 complex on canine blood mononuclear cells (BMC), by analyzing lipid A- or lipid IVa-induction of TNF-α production from these cells in order to understand canine innate immune system. After 5-h culture of canine BMC with lipid A (lipid A culture) or lipid IVa (lipid IVa culture), the TNF-α, as determined by ELISA, had increased in the supernatants of the lipid A cultures in a dose-dependent manner, whereas the TNF-α was undetectable in supernatant of lipid IVa-treated cultures. The TNF-α was statistically significantly different between the lipid A and lipid IVa cultures (100 and 1000 ng/ml). TNF-α production from canine BMC was inhibited, in a lipid IVa-dose-dependent manner, when the BMC were pre-cultured with lipid IVa for 60 min and then cultured with lipid A for 5h, while in control BMC cultures production if TNF-α was unchanged. These results indicate that the TNF-α production stimulated by lipid A was competed out by pre-exposing the BMC to lipid IVa. Thus, lipid A is an agonist for TNF-α production in canine BMC, whereas lipid IVa appears to be an antagonist against this lipid A stimulation of canine BMC. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Phytosterols and blood lipid risk factors for cardiovascular disease

    NARCIS (Netherlands)

    Ras, R.T.

    2014-01-01

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Lifestyle improvements including dietary changes are important for CVD prevention. This thesis aimed to advance insights in the role of phytosterols, lipid-like compounds present in foods or plant origin, in the

  17. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants

    DEFF Research Database (Denmark)

    Damsgaard, C.T.; Schack-Nielsen, L.; Michaelsen, K.F.

    2006-01-01

    Animal and epidemiologic studies indicate that early nutrition has lasting effects on metabolism and cardiovascular disease risk. In adults, (n-3) long-chain PUFA (LCPUFA) from fish oils improve blood pressure, the lipid profile, and possibly cardiovascular disease mortality. This randomized trial...... is the first to investigate the effects of fish oil on blood pressure and the lipid profile in infancy. Healthy term 9-mo old infants In 83) were randomly assigned to 5 mL fish oil daily or no fish oil for 3 mo and to 2 different milk types. Before and after the intervention, blood pressure was measured...... with an oscillometric device, and blood was sampled for analysis of erythrocyte fatty acid composition and the plasma lipid profile. This paper examines the effects of the fish oil supplement, with adjustment for the effects of the milk intervention when relevant. The fish oil intervention increased erythrocyte (n-3...

  18. Levels of lipid peroxidation, nitric oxide, and antioxidant vitamins in plasma of patients with fibromyalgia.

    Science.gov (United States)

    Akkuş, Selami; Naziroğlu, Mustafa; Eriş, Sevilay; Yalman, Kadir; Yilmaz, Nigar; Yener, Mahmut

    2009-06-01

    The etiology of fibromyalgia is not clearly understood. In recent years, a few studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of fibromyalgia. The aim of this study was to investigate plasma antioxidant vitamins, lipid peroxidation (LP), and nitric oxide (NO) levels in patients with fibromyalgia and controls. The study was performed on the blood plasma of 30 female patients and 30 age-matched controls. After a fast of 12 h, blood samples were taken, and plasma samples were obtained for measurement of vitamins A, C, E, and beta-carotene concentrations and levels of LP and NO. Concentrations of vitamins A (p fibromyalgia than in controls, and LP levels were significantly (p vitamin C and beta-carotene and levels of NO did not change significantly. These results provide some evidence for a potential role of LP and fat-soluble antioxidants in the patients with fibromyalgia.

  19. Work related stress and blood glucose levels.

    Science.gov (United States)

    Sancini, A; Ricci, S; Tomei, F; Sacco, C; Pacchiarotti, A; Nardone, N; Ricci, P; Suppi, A; De Cesare, D P; Anzelmo, V; Giubilati, R; Pimpinella, B; Rosati, M V; Tomei, G

    2017-01-01

    The aim of the study is to evaluate work-related subjective stress in a group of workers on a major Italian company in the field of healthcare through the administration of a valid "questionnaire-tool indicator" (HSE Indicator Tool), and to analyze any correlation between stress levels taken from questionnaire scores and blood glucose values. We studied a final sample consisting of 241 subjects with different tasks. The HSE questionnaire - made up of 35 items (divided into 7 organizational dimensions) with 5 possible answers - has been distributed to all the subjects in occasion of the health surveillance examinations provided by law. The questionnaire was then analyzed using its specific software to process the results related to the 7 dimensions. These results were compared using the Pearson correlation and multiple linear regression with the blood glucose values obtained from each subject. From the analysis of the data the following areas resulted critical, in other words linked to an intermediate (yellow area) or high (red area) condition of stress: sustain from managers, sustain from colleagues, quality of relationships and professional changes. A significant positive correlation (p <0.05) between the mean values of all critical areas and the concentrations of glucose values have been highlighted with the correlation index of Pearson. Multiple linear regression confirmed these findings, showing that the critical dimensions resulting from the questionnaire were the significant variables that can increase the levels of blood glucose. The preliminary results indicate that perceived work stress can be statistically associated with increased levels of blood glucose.

  20. Blood lead levels of British competitive cyclists.

    Science.gov (United States)

    Atkinson, G; Maclaren, D; Taylor, C

    1994-01-01

    This study examined the extent to which the potentially toxic lead particulates emitted from motor vehicles are absorbed by competitive cyclists. A time trial (n = 5), a road race (n = 5), and a sedentary control group (n = 5) were examined with respect to blood lead (PbB) levels. In the two cycling groups, the PbB levels were measured before and after (1) a time trial (80 km) held on a dual carriageway; and (2) a road race (120 km) which took place in a rural area. Mean (+/- SE) resting PbB levels for the sedentary subjects, time trialists, and road racers were 0.442 +/- 0.041, 0.490 +/- 0.111 and 0.384 +/- 0.061 mumol l-1 respectively (p > 0.05). Mean post-race PbB levels of the time trialists (0.528 +/- 0.046 mumol l-1) and road racers (0.346 +/- 0.024 mumol l-1) did not differ significantly from the pre-race levels (p > 0.05). However, after their respective races, the mean PbB level of the time trialists was higher than that of the road racers (p cycling (70% VO2 max) in a laboratory containing approximately 1 microgram m3 of airborne lead did not affect blood lead levels. All PbB levels compiled with EC regulations regarding lead exposure. Despite a positive relationship between the amount of training and the PbB levels (r = 0.64, p road racing.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Oral dehydroepiandrosterone (DHEA) replacement in older adults: effects on central adiposity, glucose metabolism, and blood lipids

    Science.gov (United States)

    Jankowski, Catherine M.; Gozansky, Wendolyn S.; Van Pelt, Rachael E.; Wolfe, Pamela; Schwartz, Robert S.; Kohrt, Wendy M.

    2011-01-01

    Objective The aim was to determine the effects of dehydroepiandrosterone (DHEA) therapy on changes in central adiposity, insulin action, and blood lipids. Many of the actions of DHEA in humans are thought to be mediated through its conversion to sex hormones, which are modulators of adiposity, muscularity, and insulin sensitivity. The effects of DHEA replacement on regional tissue composition, glucose metabolism, and blood lipid profile in older adults have been inconsistent. Design a randomized, double-blinded, placebo-controlled trial. The intervention was oral DHEA 50 mg/d or placebo for 12 months. Participants 58 women and 61 men, aged 60–88 yr, with low serum DHEA sulfate (DHEAS) levels at study entry. Measurements Computed tomography measures of abdominal fat areas, thigh muscle and fat areas, DXA-derived trunk fat mass, serum glucose and insulin responses to an oral glucose challenge, and fasted serum total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides were assessed before and after the intervention. Results There were no significant (P > 0.05) differences between the DHEA and placebo groups in the changes in regional tissue composition or glucose metabolism. HDL-cholesterol (P =0.01) and fasted triglycerides (P =0.02) decreased in women and men taking DHEA. Conclusion Restoring serum DHEAS levels in older adults to young adult levels for 1 year does not appear to reduce central adiposity or improve insulin action. The benefit of DHEA on decreasing serum triglycerides must be weighed against the HDL-lowering effect. PMID:21521341

  2. Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels.

    Science.gov (United States)

    Rydén, Mikael; Arner, Peter

    2017-09-01

    Fatty acids released via fat cell lipolysis can affect circulating lipid levels. However, the contribution of different lipolysis measures in adipose tissue is unknown and was presently examined in isolated subcutaneous adipocytes. One thousand and sixty-six men and women were examined for lipolysis regulation in subcutaneous abdominal fat cells. Results were compared with fasting plasma levels of total cholesterol, high-density lipoprotein (HDL) cholesterol (HDL-C) and triglycerides. Spontaneous (basal) lipolysis and the effects of the major hormones stimulating (catecholamines and natriuretic peptides) and inhibiting lipolysis (insulin) were examined. Several statistically significant (Plipolysis parameters and plasma lipids were observed. However, physiologically relevant correlations (adjusted r(2)≥0.05) were only evident between basal or insulin-inhibited lipolysis and plasma triglycerides or HDL-C. Together, these lipolysis measures explained 14% of the variation in triglycerides or HDL-C, respectively. In comparison, a combination of established factors associated with variations in plasma lipids, that is, age; body mass index; waist circumference; waist-to-hip ratio; sex; nicotine use; fat cell volume; and pharmacotherapy against diabetes mellitus; hypertension; or hyperlipidemia explained 17% and 28%, respectively, of the variations in plasma triglycerides and HDL-C. Subcutaneous fat cell lipolysis is an important independent contributor to interindividual variations in plasma lipids. High spontaneous lipolysis activity and resistance to the antilipolytic effect of insulin associate with elevated triglyceride and low HDL-C concentrations. Thus, although several other factors also play a role, subcutaneous adipose tissue may have a causal influence on dyslipidemia. © 2017 The Authors.

  3. Dietary Glycemic Index, Dietary Glycemic Load, Blood Lipids, and Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Edgar Denova-Gutiérrez

    2010-01-01

    Full Text Available Objective. To examine the associations of dietary glycemic index (GI and dietary glycemic load (GL with blood lipid concentrations and coronary heart disease (CHD in nondiabetic participants in the Health Worker Cohort Study (HWCS. Materials and Methods. A cross-sectional analysis was performed, using data from adults who participated in the HWCS baseline assessment. We collected information on participants' socio-demographic conditions, dietary patterns and physical activity via self-administered questionnaires. Dietary GI and dietary GL were measured using a validated food frequency questionnaire. Anthropometric and clinical measurements were assessed with standardized procedures. CHD risk was estimated according to the sex-specific Framingham prediction algorithms. Results. IIn the 5,830 individuals aged 20 to 70 who were evaluated, dietary GI and GL were significantly associated with HDL-C, LDL-C, LDL-C/HDL-C ratio, and triglycerides serum levels. Subjects with high dietary GI have a relative risk of 1.56 (CI 95%; 1.13–2.14, and those with high dietary GL have a relative risk of 2.64 (CI 95%; 1.15–6.58 of having an elevated CHD risk than those who had low dietary GI and GL. Conclusions. Our results suggest that high dietary GI and dietary GL could have an unfavorable effect on serum lipid levels, which are in turn associated with a higher CHD risk.

  4. Blood lipid, glucose and uric acid levels in patients with chronic spontaneous urticaria%慢性自发性荨麻疹患者血脂、空腹血糖与尿酸水平的测定

    Institute of Scientific and Technical Information of China (English)

    孙瑞凤; 齐婧; 连石; 朱威

    2016-01-01

    Serum triglyceride ( TG ) , total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL-C) , high density lipoprotein cholesterol ( HDL-C) , uric acid ( UA) levels and fasting blood glucose ( FBG) were measured in 67 patients with chronic spontaneous urticaria ( CSU ) and 66 healthy subjects ( controls).Results showed that the rates of increased serum TG and FBG levels in CSU patients were higher than those in controls ( 19% vs.6%,χ2 =5.309, P 0.05).The rate of rising FBG in CSU patients accompanied by angioedema(4/9)was higher than that in CSU patients without angioedema(7%,χ2 =7.181,P<0.05).%回顾分析2013年12月1日至2015年1月1日诊治的67例慢性自发性荨麻疹( CSU)患者的血清TG、TC、LDL-C、HDL-C、空腹血糖和尿酸水平,并与66例健康体检者比较。 CSU伴TG升高率(19%,13/67)高于对照组和空腹血糖升高率(12%,8/67)均高于对照组(6%,4/66;1%,1/66),差异均有统计学意义(χ2=5.309,P<0.05;χ2=4.194,P <0.05);CSU患者中 TC 升高率(7%,5/67)、LDL-C升高率(4%,3/67)、HDL-C降低率(6%,4/67)、尿酸升高率(6%,4/67),与对照组[3%(2/66)]、1%(1/66)、3%(2/66)、1%(1/66)]相比,差异均无统计学意义(均P>0.05)。 CSU伴发血管性水肿者的空腹血糖升高比例(4/9)高于CSU不伴发血管性水肿者(7%,4/58),差异有统计学意义(χ2=7.181,P<0.05)。提示CSU患者可伴有TG或空腹血糖升高,伴发血管性水肿者可伴有空腹血糖升高。

  5. Assessment of the levels of hexachlorocyclohexane in blood samples from Mexico.

    Science.gov (United States)

    Trejo-Acevedo, Antonio; Rivero-Pérez, Norma Edith; Flores-Ramirez, Rogelio; Orta-García, Sandra Teresa; Pruneda-Álvarez, Lucia Guadalupe; Pérez-Maldonado, Iván N

    2012-06-01

    The aim of this study was to evaluate hexachlorocyclohexane (HCH) exposure in children living in nine hot spots in four Mexican states. We analyzed HCH (α, β, and γ-isomers) in blood using gas chromatography/mass spectrometry. HCH exposure level in 261 children was assessed and approximately 75 % of the children studied had detectable levels of HCH. These levels ranged from 188 to 40,096.7 ng/g lipid. The highest mean levels were found in Lacanja (5,446.9 ng/g lipid), an indigenous community in Chiapas, Mexico. Our data indicate high exposure to HCH in children living in these communities.

  6. Determination of lipid peroxide and superoxide dismutase in blood and tissueof patients with gastrointestinal cancer

    Institute of Scientific and Technical Information of China (English)

    Tian Xing Zhou; Jian Sheng Li; Lu Wei Xing; Shu Heng You

    2000-01-01

    AIM To study the relationship between the lipid peroxide (LPO) and superoxide dismutase (SOD) and thepathogenesis of gastrointestinal cancers.METHODS We investigated the SOD activity and LPO levels in blood and mucosa of patients withesophageal (EC), gastric (GC) and colorectal cancer (CC), gastric ulcer (GU) and compared with normalesophagus (NE), stomach (NS) and colon (NC). respectively, 287 patients who underwent endoscopy werestudied. SOD activity of the tissue and blood was determined using SUN's adrenaline auto oxidation method.LPO levels were determined according to YU's method.RESULTS The SOD activity and LPO level in blood and mucosa are shown in the Table 1 (x±Sx). Table 1 SOD and LPO in blood and tissues of patients with gastrointestinal cancers SOD(U/mg protein) LPO(U/mg) Groups n Tissue blood Tissue Blood Normal stomach Gastric ulcer Gastric cancer Normal esophagus Esophageal cancer Normal colon Colon cancer 60 42 43 32 52 28 30 1.90±0.18 0.64±0.40a 0.37±0.24a 1.17±0.70 0.39±0.30a 0.81±0.36 0.31±0.17b 33.70±1.73 25.50±0.67b 27.86±1.02b 30.80±3.78 28.23±10.63 20.97±4.77 19.35±7.32 0.01±0.004 0.05±0.010b 0.06±0.021b 0.014±0.005 0.061±0.033b 0.012±0.003 0.069±0.015b 0.83±0.01 0.11±0.02 0.12±0.03 0.08±0.02 0.11±0.02 0.08±0.03 0.11±0.02 aP<0.001, bp<0.01 vs corresponding normal controls, respectively. CONCLUSION SOD activity of the tissue is significantly decreased in EC. GC and CC. LPO levels weresignificantly higher than those of corresponding normal tissue. These results suggest that mucosal SOD andLPO levels are closely related to the pathogenesis of the gastrointestinal cancers.

  7. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients.

    Science.gov (United States)

    Król, Ewelina; Krejpcio, Zbigniew; Byks, Hanna; Bogdański, Paweł; Pupek-Musialik, Danuta

    2011-11-01

    Chromium(III) is considered as an essential element for carbohydrate and lipid metabolism. The aim of this clinical study was to evaluate the efficacy of Cr brewer's yeast supplementation on body mass, carbohydrate, lipids and mineral indices in type 2 diabetic patients. Twenty adult type 2 diabetic subjects (11 males and 9 females aged 37-63) were supplemented with Cr brewer's yeast in dosages of 500 μg Cr/person/day or placebo for 8 weeks in a double-blind, placebo-controlled crossover design. It was found that supplemental Cr did not affect body mass, blood lipid profile, resistin levels, and the serum and hair Zn, Fe, and Cu levels, but increased serum Cr (by 116%) and hair Cr (by 20.6%) concentrations and improved some blood carbohydrate indices (significant increase in the β cell function index by 18.8%) in type 2 diabetic patients. In conclusion, Cr brewer's yeast has a weak hypoglycemic potential, but does not affect body mass, blood biochemical profile, and microelement levels in type 2 diabetic subjects.

  8. Effect of extracorporeal ultraviolet blood irradiation on blood cholesterol level

    Science.gov (United States)

    Zalesskaya, G. A.; Laskina, O. V.; Mitkovskaya, N. P.; Kirkovsky, V. V.

    2012-07-01

    We have studied the effect of extracorporeal ultraviolet blood irradiation on cholesterol metabolism in patients with cardiovascular diseases. We have carried out a comprehensive analysis of the spectral characteristics of blood and plasma, gas-exchange and oximetry parameters, and the results of a complete blood count and chemistry panel before and after UV blood irradiation. We have assessed the changes in concentrations of cholesterols (total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides) in the blood of the patients in response to a five-day course of UV blood irradiation. The changes in the spectral characteristics of blood and plasma, the chemistry panel, the gas composition, and the fractional hemoglobin composition initiated by absorption of UV radiation are used to discuss the molecular mechanisms for the effect of therapeutic doses of UV radiation on blood cholesterols.

  9. [Lipid profile from low socioeconomic level preschool children. Valencia, Venezuela].

    Science.gov (United States)

    Solano, Liseti; Velásquez, Emma; Naddaf, Gloria; Páez, María

    2003-01-01

    Overweight and obesity are a public health problem worldwide affecting adults and children as well. The aim of this study was to assess overweight, lipid profile and cardiovascular risk ratios in 390 preschool children from low socio-economic level from Valencia, Venezuela. Nutritional anthropometric evaluation measured by body dimensions, and serum determination of cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and cardiovascular risk factors, were determined. 95% of the children were in relative and critical poverty. 14.3% of undernutrition and 20.8% of overweight was found. Lipid profile was in normal range, with no significant differences by sex, but higher values for HDL-cholesterol and risk ratios were found in children aged 1 to 3.99 years. Even though no differences were found by nutritional status, overweight children had higher values for lipids, except HDL-cholesterol. 6.3% of overweight children had cholesterol > or =170 mg/dL, 16.5% LDL-cholesterol > or =110 mg/dL, 40.5% triglycerides > or =75mg/dL and 100% HDL-cholesterol Nutritional and educational intervention should be addressed.

  10. Clinical Study of Blood Lipid, hs-CRP and cTnI Levels in Patients with Pre-eclampsia%子痫前期患者血脂、超敏-C反应蛋白和心肌肌钙蛋白I水平的临床研究

    Institute of Scientific and Technical Information of China (English)

    沈菊芳; 潘巨龙; 石冬敏

    2014-01-01

    目的:探讨子痫前期患者治疗前后血脂和血浆超敏-C反应蛋白(hs-CRP)、心肌肌钙蛋白I(cTnI)水平的临床意义。方法2012年1月~2013年6月轻度子痫前期组患者35例、重度子痫前期组37例,酶循环法测定血清甘油三酯(TG)、胆固醇(TC),直接法测定低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),免疫比浊法测定hs-CRP,化学发光法测定cTnI,60例正常孕妇为对照组。结果与对照组比较,治疗前,子痫前期患者TC、TG、LDL-C、hs-CRP、cTnI增高,HDL-C降低(P<0.01);治疗后,轻度子痫前期组恢复正常(P>0.05),重度子痫前期组除TG外,其他仍增高(P<0.01)。重度子痫前期组与轻度子痫前期组比较,TC、TG、LDL-C、hs-CRP、cTnI较高, HDL-C低,差异均有统计学意义(P<0.01)。结论子痫前期患者血脂、hs-CRP和cTnI水平是观察病情和疗效的量化指标。%Objective To explore the clinical significance of blood lipid, plasma hs-CRP and cTnI levels in patients with pre-eclampsia. Methods The blood lipid, hs-CRP and cTnI levels were determined in patients with pre-eclampsia (including 35 cases mild pre-eclampsia and 37 cases severe pre-eclampsia) and 60 controls by biochemistry, particle immune turbidity and chemiluminescence immunoassay as well as did compared analysis. Results Before therapy, the serum TC, TG and LDL-C levels in patients with pre-eclampsia were significantly higher than those in normal controls, but the serum HDL-C level was decreased (P0.05). Those indexes in patients with severe pre-eclampsia still increase except TG (P<0.01). Compared with the patients with mild pre-eclampsia, the TC, TG, LDL-C, plasma hs-CRP and cTnI levels in patients with severe pre-eclampsia were higher, but the serum HDL-C level was lower. The difference between them had statistical significance (P<0.01). Conclusion Monitoring the blood lipid, hs

  11. Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials.

    Science.gov (United States)

    Cho, Young Ae; Kim, Jeongseon

    2015-10-01

    Previous clinical studies have reported mixed results regarding the effect of probiotics on lipid metabolism. Therefore, we conducted a meta-analysis of randomized controlled trials to quantify the direction and magnitude of the potential effect of probiotics on blood lipid concentrations.Eligible studies were randomized, placebo-controlled trials whose interventions were probiotic products containing live bacteria. The studies reported net changes in lipid profiles (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) and their associated standard deviations (or the data to calculate them). The probiotic products did not contain prebiotics or other active ingredients, and the full article was accessible in English.The pooled mean net change in lipid profiles and 95% confidence intervals (95% CIs) were calculated. Q statistics and I were calculated to examine heterogeneity. Potential sources of heterogeneity were investigated via subgroup and sensitivity analyses, and publication biases were estimated.A total of 30 randomized controlled trials with 1624 participants (828 in intervention groups and 796 in placebo groups) were included in this analysis. Subjects treated with probiotics demonstrated reduced total cholesterol and LDL cholesterol compared to control subjects by 7.8 mg/dL (95% CI: -10.4, -5.2) and 7.3 mg/dL (95% CI: -10.1, -4.4), respectively. There was no significant effect of probiotics on HDL cholesterol or triglycerides. The effect of probiotics on total cholesterol and LDL cholesterol depended on a variety of factors. The significant effects were greater for higher baseline total cholesterol levels, longer treatment durations, and certain probiotic strains. In addition, these associations seem stronger in studies supported by probiotics companies.The studies included in this meta-analysis showed significant heterogeneity as indicated by the Q statistics and I. In addition, industry sponsorship may affect study findings

  12. [Effects of Yifuning capsule on blood lipids of ovariectomized hyperlipidemia rats].

    Science.gov (United States)

    Wang, Zhi-xia; Deng, Hong-zhu; Chen, Jian-guo; Liu, Pei-zhong

    2006-03-01

    To observe the effects of Yifuning (YEN) capsule on blood lipids of ovariectomized hyperlipidemia rats. Fifty-six female mature Sprague-Dawley rats were randomized into 7 groups: normal control group, model control group, diethylstilbestrol tablets (DT) group, Xuezhikang group, YFN high, middle and low dose groups. The ovariectomized rats were fed on high fat diet and administrated with the drugs for 3 weeks, then were killed and estimated body weight, liver index and five items of blood lipid (TC, TG, HDL-C, LDL-C, VLDL) by test kit. Enzyme (such as HP, LDL, and whole lipase) was detected too. The weight and liver index of model control group increased obviously as compared with normal group. YFN could reduce TG, TC, and LDL-C (P LDL and whole lipase (P < 0.05) on the other hand. YFN can ameliorate blood lipids of ovariectomized hyperlipidemia rats.

  13. [Regularities of endogenous lipid metabolites formation in phorbol 12-miristate 13-acetate-stimulated peripheral blood lymphocytes at leukemia].

    Science.gov (United States)

    Batikian, T B; Akopian, G V; Lazian, M P; Torgomian, T R; Kazarian, R A; Amirkhanian, E S; Tadevosian, Iu V

    2011-01-01

    Regularities of biologically active lipid metabolites formation in dynamics (5, 10, 30, 60 s) by phorbol 12-miristate 13-acetate stimulation in [14C]palmitic acid have been investigated in normal and leukemia peripheral blood lymphocytes prelabeled with [14C]palmitate. In normal cells there was two-phase formation of 1,2-diacylglycerol (5, 30 s), lysophosphatidylcholine (10, 60 s), as well as free palmitic acid at 10 s of stimulation. Under the identical experimental conditions there was inhibition of investigated lipid release processes at early (5 and 10 s) stages of stimulation of leukemic lymphocytes. At later (30, 60 s) terms of these lymphocytes the activation, basically, similar to norm changes in the formation of palmitic acid-containing metabolites except free palmitic acid (the level of which raised only at 60 second of the post-stimulation) was found. Various protein kinases C are involved in the regulation of investigated lipid levels at certain stages of signal transduction both in norm, and in blast cells. Short-term (5, 10 s) activations of healthy donors lymphocytes are coupled to functioning of Ca2+-independent isoforms of protein kinase C. The inhibition of this protein kinase C in leukemic cells leads to normalization of the investigated lipid release. The data obtained suggests disorders of early membrane-bound reactions in agonist - and a protein kinase C-mediated processes of formation palmitic acid-containing lipid metabolites in the leukemic cells in comparison with the norm.

  14. Lipid levels among African and Middle-Eastern Bedouin populations.

    Science.gov (United States)

    Dreiher, Jacob; Cohen, Arnon D; Weitzman, Shimon; Sharf, Amir; Shvartzman, Pesach

    2008-06-01

    Previous studies observed higher high-density lipoprotein (HDL) levels and lower triglycerides levels among people of African ancestry. The goal of this study was to characterize lipid levels in Bedouins of African vs. Middle-Eastern ethnicity. A cross-sectional study was conducted in a Bedouin primary care clinic in southern Israel, with 4470 listed individuals over the age of 21, of whom 402 (9%) were of African origin. A stratified random sample was included in the analysis. Associations between ethnicity, age, gender and lipid levels were assessed. Multiple linear regression and logistic regression models were used for multivariate analysis. The study included 261 African Bedouins and 406 Middle-Eastern Bedouins. (median age: 37 years, 58.6% females). The average total cholesterol and low-density lipoprotein (LDL) levels were 10 mg/dl lower among African Bedouins as compared to Middle-Eastern Bedouins (total cholesterol: 168.6 vs. 179.6 mg/dl, p<0.001; LDL: 99.5 vs. 109.0 mg/dl, respectively, p<0.001). Average triglycerides levels were 36 mg/dl lower among African Bedouins as compared to Middle-Eastern Bedouins (102.8 vs. 138.9 mg/dl, respectively, p<0.001). Average HDL levels were 3 mg/dl higher among African Bedouins as compared to Middle-Eastern Bedouins (48.3 vs. 44.6 mg/dl, respectively, p<0.001). A lower prevalence of dyslipidemia was found in African Bedouins, as compared with Middle-Eastern Bedouins.

  15. Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

    Directory of Open Access Journals (Sweden)

    Mueller Patricia W

    2010-04-01

    Full Text Available Abstract Background The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. Methods Using data from the second phase (1991-1994 of the Third National Health and Nutrition Examination Survey (NHANES III, we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C, low-density lipoprotein cholesterol (LDL-C, total cholesterol (TC, and triglycerides (TG. Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American. Results Variants within APOE (rs7412, rs429358, PON1 (rs854560, ITGB3 (rs5918, and NOS3 (rs2070744 were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. In non-Hispanic whites, no individual polymorphisms were associated with any lipid trait. However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. In non-Hispanic blacks, APOE variant rs7412 and haplotype T-T were strongly associated with LDL-C and TC; whereas, rs5918 of ITGB3 was significantly associated with TG. Several variants and haplotypes of three genes were significantly related to lipids in Mexican Americans: PON1 in relation to HDL-C; APOE and NOS3 in relation to LDL-C; and APOE in relation to TC. Conclusions We report the significant associations of blood lipids with variants and haplotypes in APOE, ITGB3, NOS3, and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample

  16. Related research of blood glucose, blood lipid and serum cystatin C and lower-extremity arterial disease in type 2 diabetic mellitus

    Institute of Scientific and Technical Information of China (English)

    Juan Zeng; Jie Ou; Yun-Mei He; Chun-Yu Cai

    2016-01-01

    Objective:To explore the relationship between levels of blood glucose, blood lipid and serum cystatin C and lower-extremity arterial disease in type 2 diabetic mellitus so as to provide the basis for the prevention and treatment of the disease.Methods:A total of 240 cases of patients with type 2 diabetic mellitus receiving physical examinations in our hospital from March 2014 to March 2015 were selected and divided into three groups. The control group was consisted of type 2 diabetes patients without lower-extremity arterial disease, the observation group 1 included type 2 diabetes patients with mild or moderate lower-extremity arterial disease, and the observation group 2 was formed by type 2 diabetes patients with severe lower-extremity arterial disease. Each group contained 80 cases. Then, the heights, weights, waist and hip circumferences of patients in the three groups were determined and the body mass index (BMI) and waist to hip ratio (WHR) were calculated; the fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (HOMA-IR), 2 h postprandial blood glucose (2 h PG) and glycosylated hemoglobin (HBA1c) in two groups were detected; and the levels of serum total cholesterol(TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apoA1), apolipoprotein B (apoB) and cystatin C (CysC) in two groups were also tested.Results:Compared with the control group, the WHR, FBG, HOMA-IR, 2 h PG, HBA1c, LDL-C, apoB and CysC all increased significantly, and the differences were statistically significant. Besides, there were statistically significances existing between the observation groups 1 and 2. What’s more, the serum levels of TC, HDL-C, TG and apoA1 in the observation groups were not significantly different from those of the control group.Conclusions: There is a close relationship between blood glucose, blood lipid, serum cystatin C level and lower-extremity arterial

  17. Calibration of a prototype NIRS oximeter against two commercial devices on a blood-lipid phantom

    DEFF Research Database (Denmark)

    Hyttel-Sorensen, Simon; Kleiser, Stefan; Wolf, Martin

    2013-01-01

    In a blood-lipid liquid phantom the prototype near-infrared spectroscopy oximeter OxyPrem was calibrated against the INVOS® 5100c adult sensor in respect to values of regional tissue oxygen haemoglobin saturation (rStO2) for possible inclusion in the randomised clinical trial - SafeBoosC. In addi......In a blood-lipid liquid phantom the prototype near-infrared spectroscopy oximeter OxyPrem was calibrated against the INVOS® 5100c adult sensor in respect to values of regional tissue oxygen haemoglobin saturation (rStO2) for possible inclusion in the randomised clinical trial - SafeBoos...

  18. To research relationship between pre-and post-menopausal periods and number of years after menopause with blood lipid level in obese women%肥胖女性绝经前后及绝经年限与血脂水平变化的研究

    Institute of Scientific and Technical Information of China (English)

    龚觉晓; 王新东; 谷明林; 于圣永; 娄彬; 沈建平

    2011-01-01

    目的 探讨肥胖女性绝经前后及绝经年限与血脂变化的关系.方法 女性肥胖组165例,测晨起空腹静脉血中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),进行组间比较,并分析绝经年限与血脂水平的相关性.并与179例对照组比较.结果 绝经前、后肥胖组LDL-C、TG显著高于对照组(P<0.05),HDL-C显著低于对照组(P<0.05); TG、TC、LDL-C在肥胖组及对照组绝经后显著高于绝经前(P<0.05),肥胖组HDL-C绝经后则显著低于绝经前组(P<0.05).肥胖患者TC、LDL-C与绝经年限呈正相关(P<0.05);HDL-C与绝经年限呈负相关(P<0.05).结论 女性肥胖患者绝经后血TG、LDL-C增高,而HDL-C降低;TC、LDL-C与绝经年限呈正相关,HDL-C与绝经年限成负相关.%Objective To investigate the relationship between pre-and post-menopausal periods and number of years after menopause with lipid metabolism in obese women. Methods One hundred sixty-five obese women in pre-or post-menopausal periods were collected for the determination of blood triglycerides( TG), total cholesterol( TC ), high density lipoprotein cholesterol( HDL-C) and low density lipoprotein cholesterol( LDL-C). The blood lipid levels were compared between obesity and control groups,as well as between pre-and post-menopausal subgroups,and the relationship between number of years after menopause and blood levels lipid were analyzed. Results Obesity group in pre-and post-menopausal period had significantly higher TG and LDL-C than the control group respectively( P< 0. 05 ). lower HDL than the control group( P<0.05 ). In obesity post-menopause group and control post-menopausal group,TG、TC and LDL-C were significantly higher than pre-menopausal group( P<0. 05 ). but HDL-C was lower than those in obesity pre-menopausal group. The levels of TC and LDL-C were positively correlated with number of years after menopause ( P<0.05 ), HDL-C was negatively

  19. About the effect of the regular tai chi exercise to the blood lipid, leptin levels and bone mineral density of retired intellectual women%规律性太极拳锻炼对退休知识女性血脂、瘦素水平及骨密度的影响

    Institute of Scientific and Technical Information of China (English)

    刘长江; 刘刚

    2014-01-01

    By using the methods of questionnaire with 122 retired intellectual women, divides them into regular tai chi exercise team(42), regular hiking exercise team(40)and none exercise team(40), semi-automatic to analysis of blood lipid level, ELISA kit to detect leptin level, DEXA bone mineral density instrument detect bone mineral density to discuss the effect of the regular tai chi exercise to the blood lipid, leptin levels and bone mineral density of retired intellectual women.The result shows that the BMI,TG and leptin level of the regular tai chi exercise team is lower than regular hiking exercise team(p>0.05)and none exercise team(p0.05);HDL-C is higher than regular hiking exercise team and none exercise team(p>0.05); L2~L4(AP), Neck, Ward’s, Torch is all higher than regular hiking exercise team(p>0.05)and none exercise team(p0.05)及无锻炼组(P0.05);高密度蛋白胆固醇(HDL-C)高于规律性健身走锻炼组及无锻炼组(P>0.05);骨密度四项指标L2~L4(AP),Neck,Ward’s,Torch均高于规律性健身走锻炼组(P>0.05)及无锻炼组(P<0.05)。结论:规律性太极拳锻炼能有效地改善退休知识女性的血脂、血清瘦素水平及增大骨密度,提示这对降低心脑血管病发病危险及预防骨质疏松有积极的作用。

  20. Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study.

    Science.gov (United States)

    McNaughton, Sarah A; Mishra, Gita D; Brunner, Eric J

    2009-08-01

    Analysis of the epidemiological effects of overall dietary patterns offers an alternative approach to the investigation of the role of diet in CHD. We analysed the role of blood lipid-related dietary patterns using a two-step method to confirm the prospective association of dietary pattern with incident CHD. Analysis is based on 7314 participants of the Whitehall II study. Dietary intake was measured using a 127-item FFQ. Reduced rank regression (RRR) was used to derive dietary pattern scores using baseline serum total and HDL-cholesterol, and TAG levels as dependent variables. Cox proportional hazard regression was used to confirm the association between dietary patterns and incident CHD (n 243) over 15 years of follow-up. Increased CHD risk (hazard ratio (HR) for top quartile: 2.01 (95% CI 1.41, 2.85) adjusted for age, sex, ethnicity and energy misreporting) was observed with a diet characterised by high consumption of white bread, fried potatoes, sugar in tea and coffee, burgers and sausages, soft drinks, and low consumption of French dressing and vegetables. The diet-CHD relationship was attenuated after adjustment for employment grade and health behaviours (HR for top quartile: 1.81; 95% CI 1.26, 2.62), and further adjustment for blood pressure and BMI (HR for top quartile: 1.57; 95% CI 1.08, 2.27). Dietary patterns are associated with serum lipids and predict CHD risk after adjustment for confounders. RRR identifies dietary patterns using prior knowledge and focuses on the pathways through which diet may influence disease. The present study adds to the evidence that diet is an important risk factor for CHD.

  1. 泰脂安胶囊对血脂的调节作用及其对血清氧化低密度脂蛋白的影响%Influence of Taizhian capsule on blood lipid and ox-LDL level

    Institute of Scientific and Technical Information of China (English)

    尹义军; 汪宏良; 吴琴

    2013-01-01

    目的 观察泰脂安胶囊的调脂疗效及其对血浆氧化低密度脂蛋白(ox-LDL)水平的影响.方法 观察60例血脂异常患者服用泰脂安胶囊30、60 d后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和ox-LDL水平的变化.结果 治疗30、60 d后,患者TC、TG、LDL-C、ox-LDL水平均低于治疗前(P<0.05),HDL-C水平则升高(P<0.05).治疗60 d,调节TC、TG、LDL-C和HDL-C水平的总有效率分别为86.7%、90.0%、83.3%及85.0%.结论 泰脂安胶囊可明显改善高脂血症患者血脂代谢障碍,具有降低外周血ox-LDL水平和抗动脉粥样硬化作用.%Objective To observe the effect of Taizhian capsule on blood lipids and oxidized low-density Hpoprotein(ox-LDL) level.Methods Changes of blood levels of total cholesterol(TC) , triacylglycerol(TG) ,low density lipoprotein cholesterol(LDL-C) , high density lipoprotein cholesterol (HDL-C) and ox-LDL were analyzed in 60 patients with dyslipidemia after Taizhian capsule treating for 30 and 60 d.Results Compared with results detected before therapy,blood levels of TC,TG,LDL-C and ox-LDL was decreased after 30 and 60 d of therapy(P<0.05) ,but HDL-C level increased(P<0.05).The effective rate of Taizhian capsule were 86.7% ,90.0% ,83.3% and 85.0% for regulation of TC,TG,LDL-C and HDL-C levels.Conclusion Taizhian capsule could be effective to therapy dyslipidemia and decrease ox-LDL level.

  2. Correlation between leptin level with lipid profile and free fatty acid in liver cirrhosis patients

    Directory of Open Access Journals (Sweden)

    Siti Maryani

    2015-09-01

    Full Text Available Malnutrition is a common condition in liver cirrhotic patients. Leptin regulates body weightphysiologically by suppressing appetite and increasing energy expenditure. Leptin is higher in femalethan male. Studies have shown correlation between leptin with metabolic factors like body massindex (BMI and lipid profile in cirrhotic patients. This study was conducted to investigate thecorrelation between serum leptin levels with lipid profile and free fatty acid in male patients with livercirrhosis. This was a cross sectional study that conducted at Gastroentero-Hepatology Clinic andInternal Ward at Dr. Sardjito General Hospital, Yogyakarta. The inclusion criteria were patients withliver cirrhosis > 18 years old, male, with Child-Pugh classification B and C, and provided informedconsent. The exclusion criteria were liver cirrhotic patients with comorbidity chronic kidney disease,chronic heart failure, diabetic, cancer, infection/septic, pregnancy, breast feeding, and steroid use.Data collecting was performed by anamnesis, physical examination, abdominal ultrasonographyexamination, and blood chemistry test. Pearson test was used to evaluate the correlation betweenthe serum leptin level with the lipid profile and free fatty acid. The results showed that no significantnegative correlation was observed between the serum leptin level with the total cholesterol (r= -0.052; p=0.766, high-density lipoprotein/HDL (r= -0.078; p=0.658 and triglyceride (r= -0.170; p=0.328 in male patients with liver cirrhosis. Furthermore, no significant positive correlationwas observed between the serum leptin levels with the low-density lipoprotein/LDL (r= -0.013; p=0.942 and free fatty acid/FFA (r= 0.007; p=0.968. In conclusion, there was no correlationbetween serum leptin levels with lipid profile and FFA in male patients with liver cirrhosis.

  3. Acute modification in plasma lipid levels in ultramarathon runners.

    Science.gov (United States)

    Emed, Luiz Gustavo Marin; Passaglia, Daniela Gunther; Guerios, Surya T; João, Paula G D; Moser, André I S; Abdalla, Dulcinéia S P; Guarita-Souza, Luis Cesar; Mikilita, Emanuella Stella; Baena, Cristina Pellegrino; da Costa, Ana Beatriz Brenner Affonso; Faria-Neto, José Rocha

    2016-09-01

    We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24 h. Fourteen participants completed the run. The mean distance achieved was 133.1 km (maximum of 169.6 km). There was a trend in reduction of triglycerides and total cholesterol (P = 0.06 and 0.05, respectively), without significant modifications in high-density lipoprotein, LDL and ApoA1 levels (P = 0.16; 0.55 and 0.67). There was a marked reduction in ApoB levels (P < 0.001), correlated directly to the distance covered (Pearson R = 0.68). Accordingly, an increase in the LDL/ApoB ratio was observed. The stress of this physical activity was not associated to an increase in minimally modified LDL or oxidised LDL. Lipid profile levels were not acutely altered by prolonged physical activity. Similarly, there was no evidence of greater oxidation of LDL over a 24-h period of physical activity. The reduction in ApoB was directly proportional to the distance covered, suggesting an acute positive change in phenotype of LDL molecules.

  4. Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients.

    Directory of Open Access Journals (Sweden)

    Juergen Graessler

    Full Text Available BACKGROUND: Dyslipoproteinemia, obesity and insulin resistance are integrative constituents of the metabolic syndrome and are major risk factors for hypertension. The objective of this study was to determine whether hypertension specifically affects the plasma lipidome independently and differently from the effects induced by obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: We screened the plasma lipidome of 19 men with hypertension and 51 normotensive male controls by top-down shotgun profiling on a LTQ Orbitrap hybrid mass spectrometer. The analysis encompassed 95 lipid species of 10 major lipid classes. Obesity resulted in generally higher lipid load in blood plasma, while the content of tri- and diacylglycerols increased dramatically. Insulin resistance, defined by HOMA-IR >3.5 and controlled for BMI, had little effect on the plasma lipidome. Importantly, we observed that in blood plasma of hypertensive individuals the overall content of ether lipids decreased. Ether phosphatidylcholines and ether phosphatidylethanolamines, that comprise arachidonic (20:4 and docosapentaenoic (22:5 fatty acid moieties, were specifically diminished. The content of free cholesterol also decreased, although conventional clinical lipid homeostasis indices remained unaffected. CONCLUSIONS/SIGNIFICANCE: Top-down shotgun lipidomics demonstrated that hypertension is accompanied by specific reduction of the content of ether lipids and free cholesterol that occurred independently of lipidomic alterations induced by obesity and insulin resistance. These results may form the basis for novel preventive and dietary strategies alleviating the severity of hypertension.

  5. Imbalanced Hemolymph Lipid Levels Affect Feeding Motivation in the Two-Spotted Cricket, Gryllus bimaculatus.

    Directory of Open Access Journals (Sweden)

    Takahiro Konuma

    Full Text Available Insect feeding behavior is regulated by many intrinsic factors, including hemolymph nutrient levels. Adipokinetic hormone (AKH is a peptide factor that modulates hemolymph nutrient levels and regulates the nutritional state of insects by triggering the transfer of lipids into the hemolymph. We recently demonstrated that RNA interference (RNAi-mediated knockdown of the AKH receptor (AKHR reduces hemolymph lipid levels, causing an increase in the feeding frequency of the two-spotted cricket, Gryllus bimaculatus. This result indicated that reduced hemolymph lipid levels might motivate crickets to feed. In the present study, to elucidate whether hemolymph lipid levels contribute to insect feeding behavior, we attempted to manipulate hemolymph lipid levels via the lipophorin (Lp-mediated lipid transferring system in G. bimaculatus. Of the constituent proteins in Lp, we focused on apolipophorin-III (GrybiApoLp-III because of its possible role in facilitating lipid mobilization. First, we used RNAi to reduce the expression of GrybiApoLp-III. RNAi-mediated knockdown of GrybiApoLp-III had little effect on basal hemolymph lipid levels and the amount of food intake. In addition, hemolymph lipid levels remained static even after injecting AKH into GrybiApoLp-IIIRNAi crickets. These observations indicated that ApoLp-III does not maintain basal hemolymph lipid levels in crickets fed ad libitum, but is necessary for mobilizing lipid transfer into the hemolymph following AKH stimulation. Second, Lp (containing lipids was injected into the hemolymph to induce a temporary increase in hemolymph lipid levels. Consequently, the initiation of feeding was delayed in a dose-dependent manner, indicating that increased hemolymph lipid levels reduced the motivation to feed. Taken together, these data validate the importance of basal hemolymph lipid levels in the control of energy homeostasis and for regulating feeding behavior in crickets.

  6. Mendelian randomization of blood lipids for coronary heart disease

    Science.gov (United States)

    Holmes, Michael V.; Asselbergs, Folkert W.; Palmer, Tom M.; Drenos, Fotios; Lanktree, Matthew B.; Nelson, Christopher P.; Dale, Caroline E.; Padmanabhan, Sandosh; Finan, Chris; Swerdlow, Daniel I.; Tragante, Vinicius; van Iperen, Erik P.A.; Sivapalaratnam, Suthesh; Shah, Sonia; Elbers, Clara C.; Shah, Tina; Engmann, Jorgen; Giambartolomei, Claudia; White, Jon; Zabaneh, Delilah; Sofat, Reecha; McLachlan, Stela; Doevendans, Pieter A.; Balmforth, Anthony J.; Hall, Alistair S.; North, Kari E.; Almoguera, Berta; Hoogeveen, Ron C.; Cushman, Mary; Fornage, Myriam; Patel, Sanjay R.; Redline, Susan; Siscovick, David S.; Tsai, Michael Y.; Karczewski, Konrad J.; Hofker, Marten H.; Verschuren, W. Monique; Bots, Michiel L.; van der Schouw, Yvonne T.; Melander, Olle; Dominiczak, Anna F.; Morris, Richard; Ben-Shlomo, Yoav; Price, Jackie; Kumari, Meena; Baumert, Jens; Peters, Annette; Thorand, Barbara; Koenig, Wolfgang; Gaunt, Tom R.; Humphries, Steve E.; Clarke, Robert; Watkins, Hugh; Farrall, Martin; Wilson, James G.; Rich, Stephen S.; de Bakker, Paul I.W.; Lange, Leslie A.; Davey Smith, George; Reiner, Alex P.; Talmud, Philippa J.; Kivimäki, Mika; Lawlor, Debbie A.; Dudbridge, Frank; Samani, Nilesh J.; Keating, Brendan J.; Hingorani, Aroon D.; Casas, Juan P.

    2015-01-01

    Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. Methods and results We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P < 2 × 10−6); and the second a restricted score, filtered to remove any SNPs also associated with either of the other two lipid traits at P ≤ 0.01. Mendelian randomization meta-analyses were conducted in 17 studies including 62,199 participants and 12,099 CHD events. Both the unrestricted and restricted allele scores for LDL-C (42 and 19 SNPs, respectively) associated with CHD. For HDL-C, the unrestricted allele score (48 SNPs) was associated with CHD (OR: 0.53; 95% CI: 0.40, 0.70), per 1 mmol/L higher HDL-C, but neither the restricted allele score (19 SNPs; OR: 0.91; 95% CI: 0.42, 1.98) nor the unrestricted HDL-C allele score adjusted for triglycerides, LDL-C, or statin use (OR: 0.81; 95% CI: 0.44, 1.46) showed a robust association. For triglycerides, the unrestricted allele score (67 SNPs) and the restricted allele score (27 SNPs) were both associated with CHD (OR: 1.62; 95% CI: 1.24, 2.11 and 1.61; 95% CI: 1.00, 2.59, respectively) per 1-log unit increment. However, the unrestricted triglyceride score adjusted for HDL-C, LDL-C, and statin use gave an OR for CHD of 1.01 (95% CI: 0.59, 1.75). Conclusion The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain. PMID:24474739

  7. (-) Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high fat diet

    Science.gov (United States)

    (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. Recent studies have shown that EC and foods rich in EC exerted vascular protective effects. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechani...

  8. 超声和血脂水平检测对颈动脉斑块稳定性诊断的应用%Study on application of ultrasound and blood level of lipids in diagnosis of the stability of atherosclerotic plaque in carotid artery

    Institute of Scientific and Technical Information of China (English)

    于明月; 李红艳; 刘欣; 焦荣红; 薛红元; 牛慧敏; 于明娟

    2014-01-01

    Objective To evaluate the role of ultrasonic elastograsphy and blood levels of lipids in diagnosis of stability of atherosclerotic plaque in carotid artery. Methods Sixty patients diagnosed as cerebral infarction during January 2013 to December 2013 were allocated in obser_vation group and 60 healthy persons taking health examination in outpatient service were allocated in control group for prospective study. All their clinical data and history records were studied according to the actual order one by one,and blood levels of lipids including three acyl glycerin ( TG),total cholesterol( TC),low density lipoprotein cholesterol( LDL-C)and high density lipoprotein cholesterolother( HDL-C)indicators were evaluated,information of carotid plaques had been recorded by using ultrasond combined with UE( ultrasonic elastography). Results Rele_vance ratio of total carotid plaques in observation group was higher( P ﹤0. 05). The total number of cases in two groups with UE scores at 4 or less points was not statistically different,but the number of cases with UE scores at 5 points or higher in observation group was significantly higher than those of control group( P ﹤0. 05). Blood levels of lipids especially the index of LDL-C were also significantly higher in observation group ( P ﹤0. 05). Conclusion Abnormally higher LDL-C lipid indexes mean the instability of atherosclerotic plaques in carotid arteries of patients with cerebral infarction,and application of new type UE combined with technique of traditional ultrasonic imaging can more significantly raise the sensitivity of ultrasonic detection of diseased tissues;and the application of ultrasound and detection of blood levels of lipids have practical clinical significance in demonstration of the stability of carotid plaques in carotid arteries.%目的:评估超声和血脂水平检测对颈动脉斑块稳定性诊断的临床应用价值。方法将2013年1月至2013年12月住院治疗的脑梗死病人60例作为观

  9. CORRELATION OF PLASMA FIBRINOGEN WITH BLOOD PRESSURE, BMI, LIPID PROFILE AND GLYCEMIC STATUS IN TYPE II D M

    Directory of Open Access Journals (Sweden)

    Suresh

    2014-12-01

    Full Text Available BACKGROUND: Diabetes is the most common metabolic disorder all over the world3.The incidence of diabetes is showing an alarming rise in developing countries, particularly in India. Type 2 diabetes is the most prevalent form in India and constitutes more than 95% of the cases.9 During the past decade, the potential role of haemostatic factors particularly fibrinogen in various disorders and their complication has gained considerable interest. Plasma fibrinogen is a important marker in type 2 Diabetes, but its correlation with smoking, age, sex, hypertension, obesity, family history lipids, has not been evaluated in large studies. In view of paucity of data from Indian studies, we attempt to correlate plasma fibrinogen with blood pressure, BMI, lipid profile and glycemic status in type 2 diabetes mellitus. METHODS: A total of 100, known and newly detected type-2 diabetic patients with and without associated hypertension of more than 40 years of age belonging to both sexes were included. All these patients were registered cases in Basaveshwar Teaching & General Hospital, Gulbarga as outpatients and in-patients. Type-2 diabetic patients associated with myocardial infarction, stroke, chronic inflammatory diseases, tuberculosis, malignancy, secondary hypertension and pregnancy were excluded from this study. After a detailed clinical examination, the following investigations were done: For diabetes mellitus: Random blood sugar, fasting blood sugar, post-prandial blood sugar and glycosylated haemoglobin (ERBA Kit. Renal profile: Blood urea and serum creatinine. Serum lipids: Cholesterol, triglyceride (TG, high density lipoprotein (HDL and low density lipoprotein (LDL by commercially available kits (ERBA Kit. Routine urine examination: Sugar and albumin. Estimation of plasma fibrinogen: The plasma fibrinogen was estimated by thrombin-clotting method by using FIBROQUANT KIT [Tulip Diagnostics (P Ltd.]. OBJECTIVES: To know the fibrinogen levels in patients

  10. Lack of effect on blood lipid and calcium concentrations of young men on changing from white to wholemeal bread.

    Science.gov (United States)

    Heaton, K W; Manning, A P; Hartog, M

    1976-01-01

    1. When nineteen "free-living" male students, who normally ate 231 (SEM 14) g white bread/d changed to wholemeal bread for a 19-week period, there was no significant change in body-weight, plasma cholesterol or plasma triglyceride levels. These values, as well as plasma concentrations of calcium, phosphate, urate and haemoglobin, remained essentially the same as those for a control group. 2. Increasing the wheat-fibre intake by eating wholemeal bread is not an effective method for reducing blood lipids levels, at least in healthy young men with a moderate bread intake.

  11. 不同碳链长度n-3脂肪酸及脂肪水平对罗非鱼生长、肝功能和餐后血液指标的影响%Effects of n-3 Fatty Acids with Different Carbon Chain Lengths and Lipid Levels on Growth, Liver Function and Postprandial Blood Indices of Tilapia (Oreochromis niloticus)

    Institute of Scientific and Technical Information of China (English)

    林鑫; 李法见; 林仕梅; 彭祥和; 朱旺明

    2015-01-01

    An 8-week feeding trial was conducted to evaluate the effects of n-3 fatty acids with different carbon chain lengths and lipid levels on growth, liver function and postprandial blood indices of tilapia ( Oreochromis niloticus) . Four experimental diets were formulated containing either 5% fish oil ( low level of fish oil) , 10%fish oil ( high level of fish oil) , 5% linseed oil ( low level of linseed oil) or 10% linseed oil ( high level of lin-seed oil ) on the basis of practical diet formulation. A total of 360 tilapia with the initial body weight of (43.70±1.06) g were randomly distributed into 4 groups with 3 replicates per group and 30 fish per replicate, and the fish in each group were randomly fed one of four experimental diets. The results showed that no signifi-cant differences were found in finial body weight ( FBW) , specific growth rate ( SGR) , feed conversion ratio (FCR) and protein efficiency ratio (PER) of fish among all groups (P>0.05), but the feed intake (FI) in low level of linseed oil group was significantly lower than that in high level of linseed oil group ( P0.05) . Hepatopancreas malondialdehyde ( MDA) content showed a trend of high level of fish oil group>high level of linseed oil group>low level of fish oil group>low level of linseed oil group, and the difference among all groups was significant (P0.05), but the hepatopancreas SOD activity in low level of fish oil group was significantly higher than that in high level of fish oil group ( P0.05),但高水平亚麻籽油组的摄食量显著低于低水平亚麻籽油组( P0.05)。肝胰脏丙二醛( MDA)含量表现为高水平鱼油组>高水平亚麻籽油组>低水平鱼油组>低水平亚麻籽油组,且组间差异极显著( P0.05),而低水平鱼油组肝胰脏SOD活性显著高于高水平鱼油组( P<0.05)。由此可见,不同碳链长度n-3脂肪酸及脂肪水平不会影响罗非鱼的生长,但会影响其肝功能以及餐后血液指标。

  12. Effects of Cinnamomum zeylanicum (Ceylon cinnamon on blood glucose and lipids in a diabetic and healthy rat model

    Directory of Open Access Journals (Sweden)

    Priyanga Ranasinghe

    2012-01-01

    Full Text Available Objectives: To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats. Materials and Methods: The study was conducted in two phases (Phase I and Phase II, using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG (Groups 1 and 2 and on post-oral glucose (Groups 3 and 4 blood glucose. Groups 1 and 3 received distilled-water and Groups 2 and 4 received cinnamon-extracts. Phase II evaluated effects on food consumption, body weight, blood glucose, and lipids over 1 month. Group A (n = 8, distilled-water and Group B (n = 8, cinnamon-extracts were healthy rats, while Group C (n = 5, distilled-water and Group D (n = 5, cinnamon-extracts were diabetes-induced rats. Serum lipid profile and HbA1c were measured on D-0 and D-30. FBG, 2-h post-prandial blood glucose, body weight, and food consumption were measured on every fifth day. Results: Phase I: There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05. Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P < 0.05. Phase II: Between D0 and D30, the difference in food consumption was shown only in diabetes-induced rats (P < 0.001. Similarly, the significant difference following cinnamon-extracts in FBG and 2-h post-prandial blood glucose from D0 to D30 was shown only in diabetes-induced rats. In cinnamon-extracts administered groups, total and LDL cholesterol levels were lower on D30 in both healthy and diabetes-induced animals (P < 0.001. Conclusions: C. zeylanicum lowered blood glucose, reduced food intake, and improved lipid parameters in diabetes-induced rats.

  13. Effects of consumption of probiotics and prebiotics on serum lipid levels in humans.

    Science.gov (United States)

    Pereira, Dora I A; Gibson, Glenn R

    2002-01-01

    The objective of this article is to review existing studies concerning the effects of probiotics and prebiotics on serum cholesterol concentrations, with particular attention on the possible mechanisms of their action. Although not without exception, results from animal and human studies suggest a moderate cholesterol-lowering action of dairy products fermented with appropriate strain(s) of lactic acid bacteria and bifidobacteria. Mechanistically, probiotic bacteria ferment food-derived indigestible carbohydrates to produce short-chain fatty acids in the gut, which can then cause a decrease in the systemic levels of blood lipids by inhibiting hepatic cholesterol synthesis and/or redistributing cholesterol from plasma to the liver. Furthermore, some bacteria may interfere with cholesterol absorption from the gut by deconjugating bile salts and therefore affecting the metabolism of cholesterol, or by directly assimilating cholesterol. For prebiotic substances, the majority of studies have been done with the fructooligosaccharides inulin and oligofructose, and although convincing lipid-lowering effects have been observed in animals, high dose levels had to be used. Reports in humans are few in number. In studies conducted in normal-lipidemic subjects, two reported no effect of inulin or oligofructose on serum lipids, whereas two others reported a significant reduction in serum triglycerides (19 and 27%, respectively) with more modest changes in serum total and LDL cholesterol. At present, data suggest that in hyperlipidemic subjects, any effects that do occur result primarily in reductions in cholesterol, whereas in normal lipidemic subjects, effects on serum triglycerides are the dominant feature.

  14. Imipramine blood levels and clinical outcome.

    Science.gov (United States)

    Rigal, J G; Albin, H C; Duchier, A R; D'Aulnay, J M; Fenelon, J H; Vincon, G A; Demotes-Mainard, F M

    1987-08-01

    Fifty-one depressed inpatients, after 1 drug-free week, were treated for 5 weeks with imipramine 4 mg/kg day. Plasma levels of imipramine (IMI) and its active metabolite desmethylimipramine (DMI) were measured weekly, 15 hours after the last drug intake. Steady state blood levels (IMI + DMI) ranged from 60 to 585 ng/ml. The mean value for plasma concentration (IMI + DMI) at day 42 was 271 ng/ml. In the same way, therapeutic effectiveness was assessed every week using the Hamilton Rating Scale for Depression (HDRS). There was a significant correlation between plasma concentration and the decrease of Hamilton scores. The IMI/DMI ratio showed a responder-nonresponder difference; 86% patients with a ratio between 0.4 and 1 were responders. Conversely, most patients with a ratio below 0.4 or above 1 were nonresponders. The ideal ratio for clinical response would be 0.68. The ratio is a subject-specific feature, able to be an early predictor of clinical outcome.

  15. 不同程度慢性乙型肝炎血脂与HBV DNA关系研究%Relationship between blood lipid levels and HBV-DNA in patients with different stages of chronic hepatitis B

    Institute of Scientific and Technical Information of China (English)

    颜华东; 高国生; 祝成亮; 盛吉芳

    2013-01-01

    目的 探讨慢性乙型肝炎患者不同血脂指标的表达水平及其与病情轻重和HBV DNA的关系.方法 收集2011年1月至2012年10月宁波市第二医院142例慢性乙型病毒性肝炎患者以及44名健康献血员血清,检测总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoAl)、载脂蛋白B(ApoB)、载脂蛋白E(ApoE)、脂蛋白a及HBV DNA,对检测结果进行统计学分析.结果 不同病情及不同HBVDNA栽量慢性乙型肝炎患者ApoE水平均显著高于正常对照组(P均<0.05);而其他各血脂指标均低于正常对照组(P均<0.05).ApoE含量与病情轻重呈正相关,而T-CHO、HDL-C、ApoA1则呈负相关.HDL-C、ApoA1含量与HBV DNA载量呈正相关,而T-CHO、LDL-C、ApoB、ApoE则呈负相关.结论 慢性乙型肝炎患者血脂水平受肝脏合成功能以及HBV本身等多种因素的影响.%Objective To investigate the correlations of dislipidemia with disease stages and HBV-DNA in patients with chronic hepatitis B (CHB). Methods Serum samples were collected from 142 CHB patients and 44 healthy controls at Ningbo Second Hospital from January 2011 to October 2012, and the levels of TCHO, HDL-C, LDL-C, ApoAl, ApoB, ApoE, lipo and HBV-DNA were detected. The detected data were statistically analyzed. Results Regardless of disease stages and viral loads, the serum ApoE level was higher in CHB patients than that in the healthy controls ( P < 0. 05 ) , while the levels of other indicators were lower (P < 0. 05 ). The serum ApoE concentration was correlated positively with disease progression, but the levels of T-CHO, HDL-C, and ApoAl were correlated negatively with disease stages. The serum ApoAl concentration was correlated positively with HBV-DNA,but the levels of T-CHO,LDL-C, ApoB and ApoE were correlated negatively with the viral loads. Conclusion Dislipidemia is affected multiple factors such as liver synthesis function and HBV-DNA in CHB

  16. Distribuição de gordura corporal, pressão arterial e níveis de lipídios-lipoproteínas plasmáticas Body fat distribution, blood pressure and plasma lipids and lipoprotein levels

    Directory of Open Access Journals (Sweden)

    Dartagnan Pinto Guedes

    1998-02-01

    Full Text Available OBJETIVO: Investigar associações entre distribuição do tecido adiposo e níveis de pressão arterial e concentrações de lipídios-lipoproteínas plasmáticas, mediante controle de indicadores, quanto à quantidade de gordura corporal e à prática da atividade física. MÉTODOS: Estudo de 62 indivíduos com idades entre 20 e 45 anos. A distribuição do tecido adiposo foi determinada baseando-se na relação circunferência de cintura/quadril (CCQ, e como indicador da quantidade de gordura corporal recorreu-se às informações do índice de massa corporal (IMC, enquanto o nível de prática da atividade física foi estabelecido mediante estimativas do consumo máximo de oxigênio (VO2max. As associações entre CCQ e níveis de pressão arterial e de lipídios-lipoproteínas plasmáticas, com os efeitos do IMC e do VO2max controlados estatisticamente, foram estabelecidas pelo coeficiente de correlação parcial. RESULTADOS: Após correção pelo IMC verificou-se significativa correlação parcial entre a distribuição centrípeta do tecido adiposo e os níveis de pressão arterial, LDL-C e triglicerídios plasmáticos. Entretanto, controlando-se o VO2max, não foram constatadas associações significativas entre CCQ e qualquer variável sangüínea e pressão arterial.CONCLUSÃO: A distribuição centrípeta do tecido adiposo, independente da quantidade de gordura corporal, foi relacionada com concentrações de lipídios-lipoproteínas plasmáticas e níveis de pressão arterial em ambos os sexos. A prática da atividade física parece ser um importante modulador dessa associação, enfatizando seu papel no controle dos fatores de risco predisponentes às doenças cardiovasculares.PURPOSE: To study associations between FAT distribution and blood pressure levels and concentrations of lipids and lipoproteins, irrespective of body fat content and physical activity. METHODS: A sample of 62 subjects of both genders aging 20-45 years-old was

  17. Zhibitai and low-dose atorvastatin reduce blood lipids and inflammation in patients with coronary artery disease

    Science.gov (United States)

    Zhao, Yuhong; Peng, Ran; Zhao, Wang; Liu, Qiong; Guo, Yuan; Zhao, Shuiping; Xu, Danyan

    2017-01-01

    Abstract Background: Atorvastatin decreases blood lipids but is associated with side effects. Zhibitai is a traditional Chinese medicine used to treat blood lipid disorders. The objective of this study is to evaluate the lipid-lowering effect, antiinflammatory effect, and adverse events of zhibitai combined to atorvastatin in patients with coronary heart diseases (CHDs). Methods: Patients with CHD (n = 150) were randomized to: zhibitai 480 mg + atorvastatin 10 mg (ZA10 group), atorvastatin 20 mg (A20 group), and atorvastatin 40 mg (A40 group). Lipid profile, cardiotrophin-1 (CT-1), and C-reactive protein (CRP) were measured after 4 and 8 weeks of treatment. Self-reported side effects, liver function, kidney function, and creatine kinase levels were monitored. Results: After 8 weeks, triglycerides, total cholesterol (TC), LDL-cholesterol (LDL-C), and apolipoprotein B100 (ApoB100) levels were decreased in the ZA10 group (−64%, −37%, −46%, and −54%, respectively, compared with baseline), and these changes were similar to those of the A40 group (P > 0.05). CT-1 and high sensitivity-C reactive protein (hs-CRP) levels were significantly decreased in the ZA10 group after 4 and 8 weeks (4 weeks: −73% and 96%; 8 weeks: −89% and −98%; all P  0.05). After 8 weeks of treatment, adverse events (abdominal distention, nausea, vomiting, and hunger) were found in 4, 5, and 7 patients in the ZA10, A20, and A40 groups, respectively. Conclusion: ZA10 significantly reduced triglycerides, TC, LDL-C, ApoB, CT-1, and hs-CRP levels in patients with CHD, similar to the effects of A40 and A20, but ZA10 lead to fewer adverse events. PMID:28207527

  18. Diminished Lipid Raft SNAP23 Increases Blood Pressure by Inhibiting the Membrane Fluidity of Vascular Smooth-Muscle Cells.

    Science.gov (United States)

    Yoon, Mi So; Won, Kyung-Jong; Kim, Do-Yoon; Hwang, Dae Il; Yoon, Seok Won; Jung, Seung Hyo; Lee, Kang Pa; Jung, Dongju; Choi, Wahn Soo; Kim, Bokyung; Lee, Hwan Myung

    2015-01-01

    Synaptosomal-associated protein 23 (SNAP23) is involved in microvesicle trafficking and exocytosis in various cell types, but its functional role in blood pressure (BP) regulation has not yet been defined. Here, we found that lipid raft SNAP23 expression was much lower in vascular smooth-muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) than in those from normotensive Wistar-Kyoto (WKY) rats. This led us to investigate the hypothesis that this lower expression may be linked to the spontaneous hypertension found in SHR. The expression level of lipid raft SNAP23 and the fluidity in the plasma membrane of VSMCs were lower in SHR than in WKY rats. Cholesterol content in the VSMC membrane was higher, but the secreted cholesterols found in VSMC-conditioned medium and in the blood serum were lower in SHR than in WKY rats. SNAP23 knockdown in WKY rat VSMCs reduced the membrane fluidity and increased the membrane cholesterol level. Systemic overexpression of SNAP23 in SHR resulted in an increase of cholesterol content in their serum, a decrease in cholesterol in their aorta and the reduction of their BP. Our findings suggest that the low expression of the lipid raft SNAP23 in VSMCs might be a potential cause for the characteristic hypertension of SHR.

  19. The correlation between adiponectin with blood lipids and body mass index in women with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Hossain baba Ahmadi Rezaie

    2007-09-01

    Full Text Available Background: Adiponectin, also called GBP-28, apM1, Adipo Q and Acrp30, is a novel adipose tissue-specific protein. A reduction in adiponectin expression is associated with insulin resistance in some animal models. This study was performed to determine the relationship between adiponectin with blood lipids and body mass index (BMI in diabetic and healthy women. Methods: We examined serum levels of adiponectin, LDL-cholesterol, HDL-cholesterol, triglyceride and cholesterol in diabetic women (n=28 and healthy women (n=42. Adiponectin was measured by ELISA. We used Spearman coefficient to determine correlation between adiponectin with blood lipids and BMI in two studied groups. Results: We found that there was lower concentration of adiponectin in diabetic women (7.29±1.42 µg/ml than healthy women (10.29 ± 1.93 µg/ml (P<0.01 and there was a negative correlation between adiponectin and LDL-cholesterol, triglyceride, total cholesterol and BMI, but a positive correlation was assessed between adiponectin and HDL-cholesterol. Conclusion: This study suggests that adiponectin has antiaterogenic properties and confirms that high adiponectin levels correlate with better lipid profile in women with type 2 diabetes.

  20. Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females

    Directory of Open Access Journals (Sweden)

    Ola Ahmed Bakry

    2014-01-01

    Full Text Available Context: Acne vulgaris (AV is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. Subjects and Methods: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG, estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. Results: Total testosterone, free testosterone (FT and progesterone levels were significantly higher (P < 0.001 for all while estradiol levels (P < 0.001 and SHBG (P < 0.01 were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C levels were significantly higher (P < 0.001 for both while high density lipoprotein cholesterol (HDL-C and apolipoprotein A-1 (ApoA-1 levels were significantly lower (P < 0.001 for both in cases than controls. Higher values of FT (P = 0.03 and SHBG (P = 0.02 and lower values of estradiol (P = 0.04 levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001 and LDL-C (P = 0.03 and lower values of HDL-C (P = 0.01 and ApoA-1 (P = 0.02 levels were significantly associated with severe acne. Conclusion: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.

  1. Mendelian randomization of blood lipids for coronary heart disease.

    Science.gov (United States)

    Holmes, Michael V; Asselbergs, Folkert W; Palmer, Tom M; Drenos, Fotios; Lanktree, Matthew B; Nelson, Christopher P; Dale, Caroline E; Padmanabhan, Sandosh; Finan, Chris; Swerdlow, Daniel I; Tragante, Vinicius; van Iperen, Erik P A; Sivapalaratnam, Suthesh; Shah, Sonia; Elbers, Clara C; Shah, Tina; Engmann, Jorgen; Giambartolomei, Claudia; White, Jon; Zabaneh, Delilah; Sofat, Reecha; McLachlan, Stela; Doevendans, Pieter A; Balmforth, Anthony J; Hall, Alistair S; North, Kari E; Almoguera, Berta; Hoogeveen, Ron C; Cushman, Mary; Fornage, Myriam; Patel, Sanjay R; Redline, Susan; Siscovick, David S; Tsai, Michael Y; Karczewski, Konrad J; Hofker, Marten H; Verschuren, W Monique; Bots, Michiel L; van der Schouw, Yvonne T; Melander, Olle; Dominiczak, Anna F; Morris, Richard; Ben-Shlomo, Yoav; Price, Jackie; Kumari, Meena; Baumert, Jens; Peters, Annette; Thorand, Barbara; Koenig, Wolfgang; Gaunt, Tom R; Humphries, Steve E; Clarke, Robert; Watkins, Hugh; Farrall, Martin; Wilson, James G; Rich, Stephen S; de Bakker, Paul I W; Lange, Leslie A; Davey Smith, George; Reiner, Alex P; Talmud, Philippa J; Kivimäki, Mika; Lawlor, Debbie A; Dudbridge, Frank; Samani, Nilesh J; Keating, Brendan J; Hingorani, Aroon D; Casas, Juan P

    2015-03-01

    To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P Mendelian randomization meta-analyses were conducted in 17 studies including 62,199 participants and 12,099 CHD events. Both the unrestricted and restricted allele scores for LDL-C (42 and 19 SNPs, respectively) associated with CHD. For HDL-C, the unrestricted allele score (48 SNPs) was associated with CHD (OR: 0.53; 95% CI: 0.40, 0.70), per 1 mmol/L higher HDL-C, but neither the restricted allele score (19 SNPs; OR: 0.91; 95% CI: 0.42, 1.98) nor the unrestricted HDL-C allele score adjusted for triglycerides, LDL-C, or statin use (OR: 0.81; 95% CI: 0.44, 1.46) showed a robust association. For triglycerides, the unrestricted allele score (67 SNPs) and the restricted allele score (27 SNPs) were both associated with CHD (OR: 1.62; 95% CI: 1.24, 2.11 and 1.61; 95% CI: 1.00, 2.59, respectively) per 1-log unit increment. However, the unrestricted triglyceride score adjusted for HDL-C, LDL-C, and statin use gave an OR for CHD of 1.01 (95% CI: 0.59, 1.75). The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology.

  2. 亚临床甲状腺功能异常患者血脂、血糖水平的变化及相关影响因素分析%The change and affecting factors of blood lipid and glucose level in pa-tients with subclinical thyroid dysfunction

    Institute of Scientific and Technical Information of China (English)

    陈思梅

    2016-01-01

    目的:探讨亚临床甲状腺功能异常患者血脂、血糖水平的变化及相关影响因素。方法选取2011年7月~2015年6月我院收治的300例促甲状腺激素(TSH)﹤0.350 mU/L的亚临床甲状腺功能异常患者设为亚临床甲亢组、75例TSH>5.500 mU/L设为亚临床甲减组、304例健康体检者设为健康对照组,采用t检验比较亚临床甲亢组、亚临床甲减组与健康对照组的低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)、三酰甘油(TG)、总胆固醇(TC)和空腹血糖(GLU)水平,采用Pearson法分析患者的TSH、甲状腺素(T4)、三碘甲状腺原氨酸(T3)、游离甲状腺素(FT4)、游离三碘甲状原氨酸(FT3)水平与上述血脂、血糖水平的相关性,使用Logistic回归分析亚临床甲状腺功能异常患者上述血脂、血糖指标的影响因素。结果与健康对照组比较,亚临床甲亢组的HDL水平显著升高(t=2.119,P=0.034),亚临床甲减组的TC水平显著升高(t=2.036,P=0.042);亚临床甲亢组的FT3水平与其HDL水平呈显著正相关(r=0.107,P=0.009),亚临床甲减组的T4水平与GLU水平呈显著负相关(r=-0.104,P=0.044),FT3与HDL、GLU分别呈显著正、负相关(r=0.105,P=0.042;r=-0.113,P=0.028);吸烟史是患者TG水平异常的危险因素(P=0.023,OR=1.547,95%CI:0.740~1.806)。结论亚临床甲状腺功能异常患者的血脂水平异常,且与部分甲状腺功能指标相关,吸烟是患者血脂异常的危险因素。%Objective To explore the change and affecting factors of blood lipid and glucose level in patients with sub-clinical thyroid dysfunction. Methods 300 subclinical thyroid dysfunctional patients with TSH﹤0.350 mU/L received by our hospital were set as subclinical hyperthyroidism group,75 cases with TSH>5.500 mU/L were set as subclinical hy-pothyroidism group,and 300 healthy examined persons were set

  3. 阿托伐他汀对不稳定型心绞痛患者血浆C-反应蛋白和血脂的影响%Effects of atorvastatin on C-reactive protein and blood lipid levels in patients with unstable angina

    Institute of Scientific and Technical Information of China (English)

    王莉

    2014-01-01

    目的 分析阿托伐他汀对不稳定型心绞痛(UA)患者血浆C-反应蛋白和血脂的影响.方法 将200例UA患者随机分为治疗组和对照组,每组100例,两组均采用常规治疗,治疗组在此基础上给予阿托伐他汀20 mg/d,疗程12周,观察两组研究对象血脂以及炎症因子C-反应蛋白的差异,并比较两组治疗前后血脂和血浆C-反应蛋白的变化.结果 与对照组比较,治疗组可明显降低血脂及C-反应蛋白水平,差异有统计学意义(P<0.01).结论 UA患者早期应用阿托伐他汀治疗可以降低患者血浆CRP的浓度,降低胆固醇、甘油三酯和低密度脂蛋白,减轻炎症反应,稳定动脉粥样硬化斑块.%Objective To analyze the effect of atorvastatin on C-reactive protein and blood lipid levels in patients with unstable angina(UA).Methods Two hundred patients with unstable angina were randomly divided into treatment group and control group.The patients in the two groups were all given conventional treatment,and the patients in treatment group were given atorvastatin 20 mg/d,the course was 12 weeks.The levels of blood fat and C-reactive protein before and after treatment in the two groups were observed.Results Compared with control group,the levels of blood fat and C-reactive protein reduced significantly in treatment group (P < 0.01).Conclusions Early administration of atorvastatin can decrease the plasma concetration of hs-CRP,TC,TG and LDL-C significantly in patients with unstable angina,relieve the inflammatory reaction and stablize the atherosclerotic plaque.

  4. Triglyceride levels are closely associated with mild declines in estimated glomerular filtration rates in middle-aged and elderly Chinese with normal serum lipid levels.

    Directory of Open Access Journals (Sweden)

    Xinguo Hou

    Full Text Available OBJECTIVE: To investigate the relationship between lipid profiles [including total cholesterol (TC, triglyceride (TG, low-density lipoprotein cholesterol (LDL-C and high-density lipoprotein cholesterol (HDL-C] and a mild decline in the estimated glomerular filtration rate (eGFR in subjects with normal serum lipid levels. DESIGN AND METHODS: In this study, we included 2647 participants who were ≥ 40 years old and had normal serum lipid levels. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI equation was used to estimate the GFR. A mildly reduced eGFR was defined as 60-90 mL/min/1.73 m(2. First, multiple linear regression analysis was used to estimate the association of lipid profiles with the eGFR. Then, the levels of each lipid component were divided into four groups, using the 25th, 50th and 75th percentiles as cut-off points. Finally, multiple logistic regression analysis was used to investigate the association of different lipid components with the risk of mildly reduced eGFR. RESULTS: In the group with a mildly reduced eGFR, TG and LDL-C levels were significantly increased, but HDL-C levels were significantly decreased. After adjusting for age, gender, body mass index (BMI, systolic blood pressure (SBP, glycated hemoglobin (HbA1c, smoking and drinking, only TC and TG were independently related to the eGFR. Additionally, only TG showed a linear relationship with an increased risk of a mildly reduced eGFR, with the highest quartile group (TG: 108-150 mg/dl [1.22-1.70 mmol/L] having a significantly increased risk after adjusting for the above factors. CONCLUSIONS: Triglyceride levels are closely associated with a mildly reduced eGFR in subjects with normal serum lipid levels. Dyslipidemia with lower TG levels could be used as new diagnostic criteria for subjects with mildly reduced renal function.

  5. Relationship between leptin levels in maternal blood,amniotic fluid,arterial and venous cord blood and fetal growth

    Institute of Scientific and Technical Information of China (English)

    林丽莎; 薛昭卿; 宋岩峰; 何晓宇

    2003-01-01

    Objective:To study the relationship between leptin concentration and fetal growth.Methods: Levels of leptin in maternal serum, amniotic fluid, arterial and venouscord blood of 65 normal parturients (gestational age 37-42weeks) were measured by ra-dioimmunoassay (RIA) method. At the same time, maternal blood lipids were detected.Neonates were divided into three groups: small for gestational age (SGA) group (n=10), appropriate for gestational age (AGA) group (n=45), large for gestational age(LGA) group (n= 10). Statistical analysis was performed by t test, variance analysisand correlation analysis.Results: (1) There was no obvious correlation between leptin concentrations in ma-ternal serum and arterial/ venous cord blood, amniotic fluid, and also no correlationwith birth weight and placental weight (P>0.05). Maternal body mass index signifi-cantly correlated with birth weight and neonatal length and leptin levels in arterial andvenous cord blood (P<0.01). Leptin levels in arterial and venous cord blood positivelycorrelated significantly with placental and neonatal weight and body length (P<0.01)and negatively correlated with high density lipoprotein (P<0. 01). There was no obvi-ous correlation between fetal gender and leptin concentrations in maternal serum, arteri-al and venous cord blood and amniotic fluid; (2) Leptin levels in arterial and venouscord blood , placental weight in LGA group were significantly higher than those in SGAand AGA group (P<0.05). Among three groups, leptin concentrations in maternalblood were significantly higher than those in arterial and venous cord blood (P<0.05).Conclusions: (1)Fetal leptin is synthesized in uterus, born of itself and placenta.Leptin levels in arterial and venous cord blood are related to the intrauterine growthpattern. It might positively regulate birth weight and body fat content. (2)Either mater-nal or fetal leptin was not correlated with fetal gender. There is no gender difference infetal leptin

  6. Influence of electromagnetic field (1800 MHz on lipid peroxidation in brain, blood, liver and kidney in rats

    Directory of Open Access Journals (Sweden)

    Paweł Bodera

    2015-08-01

    Full Text Available Objectives: The aim of this study is the evaluation of the influence of repeated (5 times for 15 min exposure to electromagnetic field (EMF of 1800 MHz frequency on tissue lipid peroxidation (LPO both in normal and inflammatory state, combined with analgesic treatment. Material and Methods: The concentration of malondialdehyde (MDA as the end-product of the lipid peroxidation (LPO was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund’s adjuvant (CFA-induced persistent paw inflammation. Results: The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF. The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON, the exposed group (EMF, treated with tramadol (TRAM as well as exposed to and treated with tramadol (TRAM/EMF. In the group of animals treated with the complete Freund’s adjuvant (CFA we also observed slightly increased values of the MDA in the case of the control group (CON and the exposed groups (EMF and TRAM/EMF. The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly. Conclusions: The electromagnetic field exposure (EMF, applied in the repeated manner together with opioid drug tramadol (TRAM, slightly enhanced lipid peroxidation level in brain, blood, and kidneys.

  7. Effect of Sesame Oil on Diuretics or ß-blockers in the Modulation of Blood Pressure, Anthropometry, Lipid Profile, and Redox Status

    Science.gov (United States)

    Sankar, D.; Rao, M. Ramakrishna; Sambandam, G.; Pugalendi, K.V.

    2007-01-01

    The study was undertaken to investigate the effect of sesame oil in hypertensive patients who were on antihypertensive therapy either with diuretics (hydrochlorothiazide) or ß-blockers (atenolol). Thirty-two male and 18 female patients aged 35 to 60 years old were supplied sesame oil (Idhayam gingelly oil) and instructed to use it as the only edible oil for 45 days. Blood pressure, anthropometry, lipid profile, lipid peroxidation, and enzymic and non-enzymic antioxidants were measured at baseline and after 45 days of sesame oil substitution. Substitution of sesame oil brought down systolic and diastolic blood pressure to normal. The same patients were asked to withdraw sesame oil consumption for another 45 days, and the measurements were repeated at the end of withdrawal period. Withdrawal of sesame oil substitution brought back the initial blood pressure values. A significant reduction was noted in body weight and body mass index (BMI) upon sesame oil substitution. No significant alterations were observed in lipid profile except triglycerides. Plasma levels of sodium reduced while potassium elevated upon the substitution of sesame oil. Lipid peroxidation (thiobarbituric acid reactive substances [TBARS]) decreased while the activities of superoxide dismutase (SOD), catalase (CAT), and the levels of vitamin C, vitamin E, ß-carotene, and reduced glutathione (GSH) were increased. The results suggested that sesame oil as edible oil lowered blood pressure, decreased lipid peroxidation, and increased antioxidant status in hypertensive patients. PMID:17876372

  8. 奥拉西坦对急性脑出血患者Hcy、hs-CRP、尿酸、半胱氨酸蛋白酶抑制剂及血脂指标水平的影响%Effect of oxiracetam on Hcy, hs-CRP, uric acid, cysteine protease inhibitors and blood lipid levels in patients with acute cerebral hemorrhage

    Institute of Scientific and Technical Information of China (English)

    高艳秋

    2016-01-01

    Objective To investigate the effect of oxiracetam on (Hcy), high sensitive C-reactive protein (hs-CRP), uric acid (UA) and cysteine protease inhibitor (Cys C) and blood lipid index level in patients with acute cerebral hemorrhage.Methods 98 patients with acute cerebral hemorrhage were randomly divided into observation group ( n =49 ) and control group ( n =49 ) .The control group was given routine treatment, the observation group was given oxiracetam treatment on the basis of control group.Two groups were treated for 2 weeks.Results The observation group after treatment NIHSS score lower than control group(P<0.05), GCS score and ADL score higher than control group (P<0.05);The serum levels of Hcy, hs-CRP, Cys, C levels lower than control group post-treatment, while the level of UA was higher than that of control group (P<0.05);The observation group TG, TC, LDL-C levels were lower than control group post-treatment ( P <0.05 ); Two groups had no severe adverse reactions. Conclusion Oxiracetam by reducing and Hcy in patients with acute cerebral hemorrhage hs-CRP, Cys C level, increased UA level, and improve blood lipid function, and thus improve symptoms.%目的:探讨奥拉西坦对急性脑出血患者同型半胱氨酸( Hcy)、超敏C-反应蛋白( hs-CRP)、尿酸( UA)、半胱氨酸蛋白酶抑制剂( Cys C)及血脂指标水平的影响。方法急性脑出血患者98例依据随机数字表法随机分为观察组49例与对照组49例。对照组采用常规治疗,观察组在对照组基础上结合奥拉西坦治疗。2组疗程均为2周。结果观察组治疗后NIHSS评分低于对照组, GCS评分和ADL评分高于对照组(P<0.05);观察组血清Hcy、hs-CRP、Cys C水平治疗后低于对照组,而UA水平高于对照组(P<0.05);观察组TG、TC、LDL-C水平治疗后低于对照组(P<0.05);2组均未见严重不良反应。结论奥拉西坦可通过降低

  9. Changes in blood lipid in elderly population following morning exercise%健康老年人晨练活动后的血脂变化

    Institute of Scientific and Technical Information of China (English)

    陈静侬

    2002-01-01

    Objective To investigate mechanisms involving the effect of exercise on blood lipid in healthy elders.Method Healthy elders aged >60 years were included in study group,In control group,age,sex and body mathched persons were included.Blood lipid was evaluated for study group before and 3 months after morning exercise.Morning exercise consisted of walking with constant velocity(60~ 80 m/min) for 40~ 50 minutes,five times a week.Level of blood lipid in study group was compared with that of control group.Result TC,TG were significantly reduced and HE increased as compared with control group 3 months after exercise(P< 0.05).No changes occurred immediately and 20 hours after first exercise(P< 0.05).Conclusion Exercise can decrease TC,TG and raise HDL-C,which is beneficial to prevention of cerebrovascular and cardiovascular diseases in healthy elders.

  10. Intravenous lipid emulsions combine extracorporeal blood purification: a novel therapeutic strategy for severe organophosphate poisoning.

    Science.gov (United States)

    Zhou, Yaguang; Zhan, Chengye; Li, Yongsheng; Zhong, Qiang; Pan, Hao; Yang, Guangtian

    2010-02-01

    Organophosphorus (OP) pesticide self-poisoning is a major clinical problem in rural Asia and it results in the death of 200,000 people every year. At present, it is lack of effective methods to treat severe organophosphate poisoning. The high mortality rate lies on the amount of toxic absorption. Intravenous lipid emulsions can be used as an antidote in fat-soluble drug poisoning. The detoxification mechanism of intravenous lipid emulsions is "lipid sink", which lipid emulsions can dissolve the fat-soluble drugs and separate poison away from the sites of toxicity. Most of organophosphorus pesticides are highly fat-soluble. So, intravenous lipid emulsions have the potentially clinical applications in treatment of OP poisoning. Extracorporeal blood purification especially charcoal hemoperfusion is an efficient way to eliminate the poison contents from the blood. We hypothesize that the combination of intravenous lipid emulsions and charcoal hemoperfusion can be used to cure severe organophosphate poisoning. This novel protocol of therapy comprises two steps: one is obtained intravenous access to infuse lipid emulsions as soon as possible; another is that charcoal hemoperfusion will be used to clear the OP substances before the distribution of OP compounds in tissue is not complete. The advantages of this strategy lie in three points. Firstly, it will alleviate the toxic effect of OP pesticide in the patients by isolation and removal the toxic contents. Secondly, the dosage of antidotes can be reduced and its side-effects will be eased. Thirdly, a large bolus of fatty acids provide energy substrate for the patients who are nil by mouth. We consider that it would become a feasible, safe and efficient detoxification intervention in the alleviation of severe organophosphate poisoning, which would also improve the outcome of the patients.

  11. Oleic and vaccenic acid levels in lipid clases of tumors.

    Science.gov (United States)

    Wood, R

    1976-07-01

    The isomeric octadecenoate composition of triglyceride, phosphatidyicholine, and phosphatidylethanolamine classes from a variety of rat and mouse tumors was examined. Phosphatidylethanolamine from the tumors contained a higher percentage of octadecenoate than reported for many normal tissues. The octadecenoate fractions of the three lipid classes from various tumors consisted of ca. 75% or greater oleate, with vaccenate making up the balance. These data indicate that the loss of lipid class specificity for isomeric octadecenoates reported in hepatomas (Lipids 10:746, 1975, and Lipids 9:987, 1974) also occurs in other tumors.

  12. Effect of different premature infant formula feedings on the levels of calcium, magnesium and blood lipid in newborn%不同早产儿配方奶喂养对新生儿钙镁及血脂水平的影响

    Institute of Scientific and Technical Information of China (English)

    张静; 黄宏云; 杨坤

    2015-01-01

    目的 探讨不同早产儿配方奶喂养对新生儿钙镁及血脂水平的影响,为早产儿保健提供理论依据.方法 120例早产儿按照随机数字法分为A,B,C组,每组40例. A组在医师指导下喂养101千卡(100 mL)雅培早产儿配方奶,B组在医师指导下喂养81千卡(100 mL)雅培早产儿配方奶,C组在医师指导下喂养S-26 早产儿配方奶. 观察3组早产儿的钙镁水平与血脂水平. 结果 A,B组早产儿的钙镁水平差异无统计学意义( P >0.05 ) ,但均显著高于 C 组( P0.05 ). 结论 雅培早产儿配方奶能够显著提高早产儿的钙镁水平,有利于骨骼的生长发育,但不会升高血脂水平,说明合理的喂养配方奶不会引起婴儿超重和肥胖的发生,是适合早产儿的喂养方式.%Objective To explore the effect of different premature infant formula feedings on the levels of calcium, magnesium and blood lipid in newborn, in order to provide a theoretical basis for the preterm child care.Methods A total of 120 cases of premature children were random-ly divided into A,B,C group, each group 40 cases.Group A was given 101 kcal(100 mL) Abbott formula preterm, group B was fed 81 kcal (100 mL) preterm children Abbott formula, group C was fed S-26 for-mula.The calcium and magnesium levels as well as lipid levels of the three groups were observed.Results The calcium and magnesium levels had no significant difference in group A and B ( P>0.05 ) , but were sig-nificantly higher than those in group C ( P 0.05 ) . Conclusion Abbott formula preterm can significantly improve the level of calcium and magnesium in preterm children, beneficial to the growth of bone.This formula did not elevate the lipid levels, indicating that jus-tify feeding infant formula milk does not cause overweight and obesity, suitable for the feeding of premature infants.

  13. Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels

    NARCIS (Netherlands)

    Kramer, NE; Smid, EJ; Kok, J; de Kruijff, B; Kuipers, OP; Breukink, E; Kramer, Naomi E.; Smid, Eddy J.

    2004-01-01

    Lipid II is essential for nisin-mediated pore formation at nano-molar concentrations. We tested whether nisin resistance could result from different Lipid II levels, by comparing the maximal Lipid II pool in Micrococcus flavus (sensitive) and Listeria monocytogenes (relatively insensitive) and their

  14. Flavonoid-rich beverage effects on lipid profile and blood pressure in diabetic patients

    Institute of Scientific and Technical Information of China (English)

    Reza; Amani; Sara; Moazen; Hajieh; Shahbazian; Kambiz; Ahmadi; Mohammad; Taha; Jalali

    2014-01-01

    AIM: To compare freeze-dried strawberry(FDS) beverage and strawberry-flavored drink effects on lipid profile and blood pressure in type 2 diabetic(T2D) patients.METHODS: In a randomized, double-blind, controlled trial, 36 subjects with T2D(23 females; mean ± SE age: 51.57 ± 10 years) were randomly divided into two groups. Participants consumed two cups of either pure FDS beverage(each cup containing 25 g freeze-dried strawberry powder equivalent to one serving of fresh strawberries; intervention group) or an iso-caloric drinkwith strawberry flavoring(similar to the FDS drink in fiber content and color; placebo group) daily for 6 wk. Anthropometric measurements, 3 d, 24 h dietary recall, and fasting blood samples were collected at baseline and at weeks 6 intervention. After lying down and relaxing for approximately 10 min, each participant’s blood pressure was recorded in triplicate with 5 min intervals; recordings were made at baseline and the trial end-point. Each participant’s lipid profile was assessed before and after intervention.RESULTS: Assessment at the weeks 6 intervention showed a significant reduction from baseline in total cholesterol levels and total cholesterol to high-density lipoprotein cholesterol(HDL-C) ratio in the intervention group(179.01 ± 31.86 to 165.9 ± 32.4 mg/L; P = 0.00 and 3.9 ± 0.88 to 3.6 ± 0.082 mg/L; P = 0.00 respectively), but the change was not significantly different between the two groups(P = 0.07, P = 0.29 respectively). Systolic blood pressure levels were significantly reduced from baseline in both the FDS and placebo drink groups(129.95 ± 14.9 to 114.3 ± 27.5 mm Hg; P = 0.02 and 127.6 ± 15.6 to 122.9 ± 14.47 mm Hg; P = 0.00 respectively), but the reduction was not significantly different between the two groups. Diastolic blood pressure was significantly reduced post-intervention in the FDS drink group compared to placebo group(78.7 ± 7.2 vs 84.4 ± 5.8; P = 0.01), the reduction was also significant within the

  15. Lipid levels as predictors of silent myocardial ischemia in a type 2 diabetic population in Havana.

    Science.gov (United States)

    Peña, Yamilé; Fernández-Britto, José E; Bacallao, Jorge; Batista, Juan F; de León, María L

    2012-01-01

    Silent myocardial ischemia is frequent in type 2 diabetics, therefore, symptoms cannot be relied upon for diagnosis and followup in these patients. Various studies relate blood lipid levels to cardiovascular diseases, and several authors describe certain lipoproteins as independent predictors of ischemia. Identify blood lipid levels that predict silent myocardial ischemia in a type 2 diabetic population in Havana. From May 2005 through May 2009, assessment was done of 220 asymptomatic type 2 diabetics in ten polyclinics in Havana using laboratory tests and Single-Photon Emission-Computed Tomography, synchronized with electrocardiogram, known as gated SPECT (gSPECT). Coronary angiography was used for confirmation when gSPECT detected ischemia. Patients were classified into two groups: gSPECT positive and gSPECT negative. Descriptive statistics (mean and standard deviation) were calculated for all variables and mean comparison tests were conducted. Classification trees were developed relating lipid values to gSPECT results, identifying optimal cutoff points for their use as indicators of silent myocardial ischemia in the total study population and for each sex separately. GSPECT found silent myocardial ischemia in 29.1% of those examined, and 68.4% of angiograms found multivessel disease. gSPECT-positive diabetics had higher levels of total cholesterol, LDL, and triglycerides (p 119.9 mg/dL, and triglycerides >107.2 mg/d; 80.4% of diabetics with these HDL and triglyceride values had ischemia. HDL was the most important normalized variable when the entire population was analyzed. Analysis by sex showed a greater percentage of silent ischemia in men (33.3%) than in women (24.8%). The most important normalized variables were LDL of >100.8 mg/dL for men and HDL of ≤44 mg/dL for women. A considerable percentage of the study population had silent myocardial ischemia. Type 2 diabetics with ischemia had higher levels of total cholesterol, LDL and triglycerides. HDL levels

  16. Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama.

    Science.gov (United States)

    Aminov, Zafar; Haase, Richard; Olson, James R; Pavuk, Marian; Carpenter, David O

    2014-12-01

    Serum lipid levels are major risk factors for cardiovascular disease. In addition to diet, exercise, genetics, age and race, serum concentrations of persistent organic pollutants (POPs) influence concentrations of serum lipids. We investigated associations between fasting concentrations of 35 polychlorinated biphenyl (PCB) congeners and nine organochlorine pesticides in relation to total serum lipids, total cholesterol, low-density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides in 525 Caucasian and African American residents of Anniston, Alabama, who were not on any lipid-lowering medication. In Model 1, data were adjusted for age, age quadratic, gender, BMI, alcohol consumption, smoking and exercise, while in Model 2, additional adjustment was done for other POPs. As compared to Caucasians, African Americans had lower levels of total lipids and triglycerides with higher concentrations of HDL cholesterol, but higher concentrations of PCBs and pesticides. Total pesticides were more strongly associated with elevations in serum lipids than were total PCBs, and the associations were stronger in African Americans. Total DDTs were not associated with serum lipids after adjustment for other POPs in either racial group, while the strongest positive associations were seen for hexachlorobenzene (HCB) in both racial groups. Racial differences in lipid profiles, concentrations of POPs and associations between POP concentrations and serum lipids are relevant to racial differences in rates of cardiovascular disease.

  17. 血清性激素、血脂水平与围绝经期症状的相关性探讨%Exploration of the correlation of serum sex hormone, blood lipid level and the symptoms of peri-menopause

    Institute of Scientific and Technical Information of China (English)

    陈怡红; 李海文; 沙伟玲; 肖纬红; 罗翠连

    2016-01-01

    Objective:To explore the correlation of serum sex hormone, blood lipid level and the symptoms of peri-menopause. Methods: 250 female cases were selected as research objects and divided into four groups: The childbearing age control group (n=60), peri menopause group (n=60), early menopause group (n=65) and post menopause group (n=65), Testosterone (T), serum estradiol (E2), triglyceride (TG), follicle stimulating hormone (FSH), and total cholesterol (TC) detection were made respectively and menopausal index (KMI) was investigated, the detection results of four groups were compared and the correlation was analyzed. Results:Compared with the childbearing age control group, the T and E2 level of peri menopause group, early menopause group and post menopause group decreased significantly while FSH level increased significantly, the difference was statistically significant (P<0.05); the TG and TC level of peri menopause group, early menopause group and post menopause group increased significantly, the difference was statistically significant (P<0.05); meanwhile, TC was positively related to KMI while TG was negatively related to KMI. Conclusion:Testosterone and estradiol decreased significantly in post menopause women while the follicle stimulating hormone increased significantly, serum estradiol was negatively related to KMI, therefore, strengthening the monitoring of the blood lipid level and serum sex hormone levels in the peri menopausal women helped to relieve the menopausal symptoms and improve the quality of women life.%目的:探析围绝经期症状与血脂水平、血清性激素之间的相关性。方法:选择250例女性为研究对象,将其分为四组,分别是育龄对照组(n=60)、围绝经期组(n=60)、绝经早期组(n=65)及绝经晚期组(n=65),分别对其进行睾酮(T)、血清雌二醇(E2)、三酰甘油(TG)、卵泡刺激素(FSH)以及总胆固醇(TC)测定,调查绝经指数(KMI),比

  18. Blood lipid associations in 18 year-old men

    Directory of Open Access Journals (Sweden)

    Leonor Poletto

    1992-10-01

    Full Text Available The association of cigarette smoking, physical activity at work, and social class with total cholesterol and with high and low density lipoprotein cholesterol were examined in a random sample of 238 males, of 18 years of age, of Rosario, Argerntina. The mean (mg/dl total serum cholesterol of the whole sample was 174.7, the high density lipoprotein cholesterol 52.8, and the low density lipoprotein cholesterol 121.5. Black tobacco consumers, evenly distributed by social class, had higher levels of total and low density lipoprotein cholesterol. Total cholesterol was higher in the high social class, differently from what smokers' distribution by social class, would lead one to expect. While a highly negative association was found between social class and physical activity at work, there were no significant diferences in lipoprotein levels between manual and non-manual workers. It is possible that the nutritional differences by social class still prevail over the smoking habit in their influence on the lipoprotein levels in these subjects.

  19. N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids

    Directory of Open Access Journals (Sweden)

    Grillo SL

    2013-08-01

    Full Text Available Stephanie L Grillo,1,* Jantana Keereetaweep,2,* Michael A Grillo,1 Kent D Chapman,2 Peter Koulen1–3 1Vision Research Center, Department of Ophthalmology, School of Medicine, University of Missouri – Kansas City, Kansas City, MO, USA; 2University of North Texas, Center for Plant Lipid Research, Department of Biological Sciences, Denton, TX, USA; 3Department of Basic Medical Science, School of Medicine, University of Missouri – Kansas City, Kansas City, MO, USA *These authors contributed equally to this work Abstract: N-Palmitoylethanolamine (NAE 16:0 is an endogenous lipid signaling molecule that has limited water solubility, and its action is short-lived due to its rapid metabolism. This poses a problem for use in vivo as oral administration requires a high concentration for significant levels to reach target tissues, and injection of the compound in a dimethyl sulfoxide- or ethanol-based vehicle is usually not desirable during long-term treatment. A depot injection of NAE 16:0 was successfully emulsified in sterile corn oil (10 mg/kg and administered in young DBA/2 mice in order to elevate baseline levels of NAE 16:0 in target tissues. NAE 16:0 levels were increased in various tissues, particularly in the retina, 24 and 48 hours following injections. Increases ranged between 22% and 215% (above basal levels in blood serum, heart, brain, and retina and induced an entourage effect by increasing levels of other 18 carbon N-Acylethanolamines (NAEs, which ranged between 31% and 117% above baseline. These results indicate that NAE 16:0 can be used as a depot preparation, avoiding the use of inadequate vehicles, and can provide the basis for designing tissue-specific dosing regimens for therapies involving NAEs and related compounds. Keywords: cannabinoid receptor, vanilloid receptor, DBA/2 mice, lipid extraction, gas chromatography, mass spectrometry

  20. 民航飞行员胱氨酸蛋白酶抑制剂C水平及其与血糖血脂关系的研究%Survey on the cystatin C level in civil pilots and its influence to blood glucose and lipid profile

    Institute of Scientific and Technical Information of China (English)

    鲁炳怀; 朱凤霞; 贺亚杰; 史丽娜; 杨静

    2009-01-01

    目的 探讨民航飞行员的胱氨酸蛋白酶抑制剂C(Cys C)水平及其与血糖血脂之间的关系. 方法 287名参加例行体检的男性飞行员(平均年龄为39.6±8.3岁),纳入本次研究,分别测定其空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及Cys C水平.对所得结果进行统计学分析. 结果 血脂代谢紊乱及空腹血糖受损的民航飞行员血清Cys C水平较正常组显著增高(P<0.01);Cys C水平与年龄无显著相关;随着脂代谢紊乱程度的增加,Cys C呈显著增高趋势(F=5.80~11.26,P<0.01);Pearson相关分析结果显示,Cys C与TG、HDL、LDL及FBG存在显著相关(P<0.05);多因素回归分析显示,TG、HDL-C、LDL-C、FBG水平是CysC水平的显著影响因素(P<0.05). 结论 Cys C水平与民航飞行员的糖、脂代谢紊乱等心血管疾病(CVD)危险因素显著相关,未来可能作为此类人群CVD发病危险评估及预警的重要指标,为飞行安全提供保障.%Objective To investigate the relationship between the levels of serum Cystatin C (Cys C) and fasting blood glucose (FBG) and lipid profiles in Chinese civil pilot. Methods Two hundred and eight-seven pilots of Civil Aviation Administration of China (Male, 39.6±8.3 yrs) were involved in the study by taking the chance of their regular physical examination. The levels of FBG, lipid profiles and Cys C were measured for final statistic analysis. Results Cys C levels of the pilots with dyslipidemia and injured glucose tolerance were significantly higher than that in normal group (P ~0.01). Cys C level was insignificantly correlated with age. Furthermore Cys C showed an increasing tendency with the deterioration of lipid metabolism (F= 5.80-11.26, P< 0.01). The multiple linear regression analysis showed that triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and FBG were the significant influence factors

  1. Effect of High Intensity Interval Training on the Body Composition,Blood Lipid and Fasting Insulin Level of Obese Female College Students%高强度间歇训练对肥胖女大学生体成分和血脂及空腹胰岛素水平的影响

    Institute of Scientific and Technical Information of China (English)

    林坚; 赵红勤; 黄雄昂; 刘晓林; 章睿

    2016-01-01

    Objective To observe the effect of high intensity interval training(HIIT)on the body composition,blood lipid and fasting insulin(FIN)level of obese female college students. Methods From January to June 2015,we recruited 36 obese female college students who accorded with inclusion and exclusion criteria from Tourism College of Zhejiang. The subjects were ranked according to BMI from low to high,and were divided into nine levels with 4 subjects in each level. Using random number table method,we divided the subjects into exercise group(n = 18)and control group(n = 18). The two groups both did exercise and education by themselves,and exercise group was also given centralized HIIT. One week before trial and one week after trial,we detected the body composition indexes(body mass,BMI,body fat,percentage of body fat,visceral fat,free fat body weight,resting metabolic rate,abdominal girth and hipline),blood lipid(TG,TC,HDL-C and LDL-C)and FIN level of the subjects. Results Exercise group had lower body mass,BMI,body fat,percentage of body fat and abdominal girth,and higher free fat body weight and resting metabolic rate than control group( P < 0. 05). Exercise group had lower body mass, BMI,body fat,percentage of body fat and abdominal girth,and higher free fat body weight and resting metabolic rate after trial than those before trial(P < 0. 05). After trial,exercise group was higher in HDL-C level and lower in LDL-C and FIN levels than control group(P < 0. 05). Exercise group had higher HDL-C level and lower LDL-C and FIN levels after trial than those before trial(P < 0. 05). Conclusion HIIT can reduce the body fat of obese female college students,increase their resting metabolic rate,better blood lipid and FIN level,which has a positive effect on the health level of obese female college students.%目的:观察高强度间歇训练(HIIT)对肥胖女大学生体成分、血脂和空腹胰岛素(FIN)水平的影响。方法2015年1—6月选取浙江旅游职业

  2. Haematological Indices, Blood glucose levels and lipid profile of rats ...

    African Journals Online (AJOL)

    Arun Kumar Agnihotri

    2015-11-11

    Nov 11, 2015 ... This work was done as a part of safety assessment to determine the effects of Tartrazine ... Acute oral toxicity has been assessed in rats; the ... contains crude protein 14.50%, crude fat. 4.80% .... Red Dye Adulterated Palm Oil.

  3. Relationship between Blood Lipids Level and Homeostasis Model Assessment-Insulin Resistance in Elder People in Chengdu%成都市成华区中老年人群血脂水平及其与胰岛素抵抗指数的关系

    Institute of Scientific and Technical Information of China (English)

    陈小妮; 陈晓平; 吴凯; 王斯; 李龙心; 万里艳

    2011-01-01

    目的 探讨成都市成华区中老年人群血脂水平、分布特点及其与胰岛素抵抗指数(HOMA-IR)的关系.方法 2007年5月在此区中老年(50~79岁)人群中随机抽取672人进行心血管危险因素研究调查,对其血脂水平及HOMA-IR进行统计分析.结果 人群当中①女性各血脂项目的 水平均比男性高,其中总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)的差异有统计学意义(P<0.05);②三酰甘油(TG)升高的比例较高,其中男性为30.0%,女性为27.6%;大部分人群HDL-C、低密度脂蛋白胆固醇(LDL-C)水平处于合适范围,HDL-C降低的比例为6.0%,LDL-C升高的比例为7.3%;③随着TG水平的升高、HDLC水平的降低,HOMA-IR呈升高趋势;LDL-C水平的升高,HOMA-IR呈升高趋势,仅在女性人群中差异有统计学意义(P<0.05),在男性人群中差异无统计学意义;④TG与HOMA-IR呈正相关,相关系数为0.185(P=0.000);HDL-C与HOMA-IR呈负相关,相关系数为-0.145(P=0.000).LDL-C与HOMA-IR呈正相关,相关系数为0.099(P=0.010).结论 TG增高是成都市成华区中老年人群的显著特点,女性HDL-C比男性高;血脂紊乱与胰岛素抵抗相关.%Objective To investigate the relationship between blood lipids level and homeostasis model assessment-insulin resistance (HOMA-IR) in elder people in Chengdu. Methods In May 2007, 672 people aged from 50 to 79 years in Chengdu were recruited by random sampling methods for the survey of cardiovascular risk factors.The blood lipids level and HOMA-IR were statistically analyzed. Results ① The serum total cholesterol (TC) and high density lipoprotein chole sterol (HDL-C) were obviously higher in women than those in men (P<0. 05). ② Triacylglycerol (TG) increased in 30. 0% of men and 27. 6% of women HDL-C and low density lipoprotein cholesterin (LDL-C) in most of the involved people were appropriate. ③ HOMA-IR increased as the TG level increased and HDL-C decreased; HOMA-IR increased as the LDL

  4. Evaluation of blood zinc, calcium and blood lead levels among children aged 1-36 months

    Directory of Open Access Journals (Sweden)

    Ji Xiaojun

    Full Text Available Background: Early childhood lead exposure is associated with numerous adverse health effects. Biomonitoring among susceptible populations, such as children, has not been previously conducted. The aim of the study is to evaluate the blood lead (Pb and total blood calcium (Ca levels; blood zinc (Zn levels. Methods: A cross-sectional study was designed to collect healthy children age 1-36 months (Mean ± SD: 1.5 ± 0.6 age, 60% boys in the study from January 2010 to September 2011. Results: The overall mean blood Pb levels were 42.18 ± 12.13 μg/L, the overall mean blood Zn and total blood Ca concentrations were 62.18 ± 12.33 μmol/L and 1.78 ± 0.13 mmol/L, respectively. The prevalence of elevated blood Pb levels in all children was 1.3%. A significant difference was found between female and male subjects for the blood Pb and Zn. After controlling for gender and age, there was a weak positive correlation between total blood Ca and Zn level. Conclusions: The blood Pb levels had a significant negative correlation with total blood Ca level after adjusting for age and gender, and these findings suggest that Pb had effect on positive blood Zn and total blood Ca levels; parents should pay more attention to the nutrition of girls.

  5. 乳腺癌患者化疗前后血脂和体质量指数的变化及其意义%The variation of blood lipid level and body mass index in breast cancer patients treated with chemotherapy and its significance

    Institute of Scientific and Technical Information of China (English)

    盛树海; 郑进; 刘广寅; 李宗涛; 潘荟丞; 佟易凡; 王欣婷; 赵魁

    2013-01-01

    Objective To investigate the variation of blood lipid level and body mass index (BMI) of breast cancer patients treated with adjuvant and neoadjuvant chemotherapy.Methods Examine the blood lipid level and body mass index before and 1 month after chemotherapy of 106 breast cancer patients,including neoadjuvant and adjuvant chemotherapy,and analyze the data with SPSS.Results (1) The levels of total cholesterol (TC),triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) and BMI examined 1 month after chemotherapy were significandy higher than those examined before chemotherapy (P < 0.05).There was no change in the level of high density lipoprotein cholesterol (HDL-C) (P > 0.05).(2) One month after chemotherapy,the levels of TG,TC and LDL-C and BMI in patients with EC-T chemotherapy were significantly higher than those in patients with CEF,FE100C and TEC regimes (P < 0.05).(3) One month after chemotherapy,the levels of TG,TC and LDL-C and BMI in patients with Ⅰ ~ Ⅱ degree emesis were significantly higher than those with Ⅲ ~ Ⅳ degree emesis (P < 0.05).There was no change in the level of HDL-C in the two groups (P > 0.05).Conclusion Breast cancer patients should pay attention to nutrition balance during chemotherapy (neoadjuvant and postoperative adjuvant chemotherapy),especially those with Ⅰ ~ Ⅱ degree emesis,avoid the elevation of blood lipid level and body mass index,and prevent relevant diseases.%目的 研究乳腺癌患者辅助及新辅助化疗前后血脂水平和体质量指数的变化及其意义.方法 选取106例接受化疗(新辅助化疗和辅助化疗)的乳腺癌患者,在化疗前和化疗疗程结束后1月查体时分别检验每位患者的血脂水平及计算其体质量指数,将所得数据进行统计分析.结果 (1)化疗后与化疗前比较,血清总胆固醇(total cholesterol,TC)、总甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平及

  6. Effect of Onsite Dietitian Counseling on Weight Loss and Lipid Levels in an Outpatient Physician Office

    Science.gov (United States)

    Welty, Francine K.; Nasca, Melita M.; Lew, Natalie S.; Gregoire, Sue; Ruan, Yuheng

    2009-01-01

    We examined the effect of an outpatient office-based diet and exercise counseling program on weight loss and lipid levels with an onsite dietitian who sees patients at the same visit with the physician and is fully reimbursable. Eighty overweight or obese patients (average age 55 ± 12 years, baseline body mass index 30.1 ± 6.4 kg/m2) with ≥1 cardiovascular risk factor (86%) or coronary heart disease (14%) were counseled to exercise 30 minutes/day and eat a modified Dietary Approaches to Stop Hypertension (DASH) diet (saturated fat <7%, polyunsaturated fat to 10%, monounsaturated fat to 18%, low in glycemic index and sodium and high in fiber, low-fat dairy products, fruits, and vegetables). Weight, body mass index, lipid levels, and blood pressure were measured at 1 concurrent follow-up visit with the dietitian and physician and ≥1 additional follow-up with the physician. Maximum weight lost was an average of 5.6% (10.8 lb) at a mean follow-up of 1.75 years. Sixty-four (81%) of these patients maintained significant weight loss (average weight loss 5.3%) at a mean follow-up of 2.6 years. Average decrease in low-density lipoprotein cholesterol was 9.3%, average decrease in triglycerides was 34%, and average increase in high-density lipoprotein cholesterol was 9.6%. Systolic blood pressure was lowered from 129 to 126 mm Hg (p = 0.21) and diastolic blood pressure from 79 to 75 mm Hg (p = 0.003). In conclusion, having a dietitian counsel patients concurrently with a physician in the out-patient setting is effective in achieving and maintaining weight loss and is fully reimbursable. PMID:17599444

  7. Disturbances in lipid second messengers generation by stimulated blood lymphocytes in breast cancer

    Directory of Open Access Journals (Sweden)

    Galstyan H. M.

    2011-10-01

    Full Text Available Aim. The main objective of this study was the comparative investigation of diverse lipid second messenger (LSM generation by human peripheral blood lymphocytes (HPBL at different (5, 10, 30 and 60 s time points of cell co-stimulation by anti-CD3 and anti-CD28 monoclonal antibodies in norm and breast cancer (BC. Methods. Ficoll-Hypaque gradient centrifugation. Results. The data obtained indicate that some mechanisms of LSM generation/utilization in stimulated crude HPBL were significantly altered in BC compared to norm. Particularly, the reliable generation of arachidonyl-1,2-diacylglycerol (1,2-DAG at the initial step (5 s of cell stimulation observed in norm was depressed in BC and reached the value below the basal level in unstimulated cells. It is important that the disturbances in 1,2-DAG formation in HPBL obtained from patients with BC were identical with those observed earlier in other forms of cancer. Conclusions. We conclude that the regularities revealed are common characteristics for all the types of malignancy studied and can be used as additional testing parameters for cancer definition and individual correction of the chemotherapy programs for disease treatment

  8. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants

    DEFF Research Database (Denmark)

    Damsgaard, C.T.; Schack-Nielsen, L.; Michaelsen, K.F.;

    2006-01-01

    Animal and epidemiologic studies indicate that early nutrition has lasting effects on metabolism and cardiovascular disease risk. In adults, (n-3) long-chain PUFA (LCPUFA) from fish oils improve blood pressure, the lipid profile, and possibly cardiovascular disease mortality. This randomized trial...... with an oscillometric device, and blood was sampled for analysis of erythrocyte fatty acid composition and the plasma lipid profile. This paper examines the effects of the fish oil supplement, with adjustment for the effects of the milk intervention when relevant. The fish oil intervention increased erythrocyte (n-3.......04) than infants not administered fish oil. Plasma triacylglycerol was inversely associated with the erythrocyte content of eicosapentaenoic acid (r = 0.34, P

  9. The correlation of the serum leptin, insulin resistance, endocrine hormone, blood lipid and of simple obesity children and growth

    Institute of Scientific and Technical Information of China (English)

    Xiao-Yu Wang; Xiao-Yun Liu; Kai-Yu Xu

    2015-01-01

    Objective:To analyze the correlation of the serum leptin, insulin resistance, Endocrine hormone, blood lipid and of simple obesity children and growth.Methods:200 cases of simple obesity children (Study Group) and 200 cases of non obese children (control group) were studied, Fasting blood glucose(FBG), Glycosylated hemoglobin (HbAlc), the serum leptin detection (Leptin), insulin (INS), insulin resistance index (HOMA2-IR), growth hormone (GH), cortisol (cortisol), thyroid hormones and blood lipid indexes were detected.Results:Leptin, cortisol and T3 levels of study group were (21.39±2.29) g/L, (18.43±1.72) g/mL and (20.71±1.82) pmol/L, were significantly increased compared with the control group, and GH level was (3.15±0.41) g/L, was significantly reduced, the difference of all these indexes were statistically significant in two groups (P0.05), HbAlc, INS and HOMA2 - IR were respectively (5.82±0.87)%, (33.02-2.34) mIU/L, (3.31-0.54), compared with the control group obviously increase than the corresponding numerical of the control group, the difference of all these indexes have statistical significance in two groups (P<0.05). TC, TG and LDL-C of study group were (4.67±0.65) mmol/L, (1.62±0.45) mmol/L and (3.59±0.46) mmol/L, were significantly higher than those in the control group, while HLD-C was (1.10±0.24) mmol/L, was significantly lower (P<0.05). Conclusion:Children with simple obesity have leptin resistance, reduction of growth hormone and endocrine and lipid metabolism disorder, and seriously affect the normal growth and development of children.

  10. FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.

    Directory of Open Access Journals (Sweden)

    Marie Standl

    Full Text Available BACKGROUND: Elevated cholesterol levels in children can be a risk factor for cardiovascular diseases in later life. In adults, it has been shown that blood lipid levels are strongly influenced by polymorphisms in the fatty acid desaturase (FADS gene cluster in addition to nutritional and other exogenous and endogenous determinants. Our aim was to investigate whether lipid levels are determined by the FADS genotype already in children and whether this association interacts with dietary intake of n-3 fatty acids. METHODS: The analysis was based on data of 2006 children from two German prospective birth cohort studies. Total cholesterol, HDL, LDL and triglycerides were measured at 10 years of age. Six single nucleotide polymorphisms (SNPs of the FADS gene cluster were genotyped. Dietary n-3 fatty acid intake was assessed by food frequency questionnaire. Linear regression modeling was used to assess the association between lipid levels, n-3 fatty acid intake and FADS genotype. RESULTS: Individuals carrying the homozygous minor allele had lower levels of total cholesterol [means ratio (MR ranging from 0.96 (p = 0.0093 to 0.98 (p = 0.2949, depending on SNPs] and LDL [MR between 0.94 (p = 0.0179 and 0.97 (p = 0.2963] compared to homozygous major allele carriers. Carriers of the heterozygous allele showed lower HDL levels [β between -0.04 (p = 0.0074 to -0.01 (p = 0.3318] and higher triglyceride levels [MR ranging from 1.06 (p = 0.0065 to 1.07 (p = 0.0028] compared to homozygous major allele carriers. A higher n-3 PUFA intake was associated with higher concentrations of total cholesterol, LDL, HDL and lower triglyceride levels, but these associations did not interact with the FADS1 FADS2 genotype. CONCLUSION: Total cholesterol, HDL, LDL and triglyceride concentrations may be influenced by the FADS1 FADS2 genotype already in 10 year old children. Genetically determined blood lipid levels during childhood might

  11. Dietary Glycemic Index, Dietary Glycemic Load, Blood Lipids, and Coronary Heart Disease

    OpenAIRE

    2010-01-01

    Objective. To examine the associations of dietary glycemic index (GI) and dietary glycemic load (GL) with blood lipid concentrations and coronary heart disease (CHD) in nondiabetic participants in the Health Worker Cohort Study (HWCS). Materials and Methods. A cross-sectional analysis was performed, using data from adults who participated in the HWCS baseline assessment. We collected information on participants' socio-demographic conditions, dietary patterns and physical activity via self-adm...

  12. 发酵桑叶对高脂血症罗非鱼血脂、血糖水平的调节作用%Regulation of Fermented Mulberry Leaves on Serum Lipid and Blood Glucose Levels of Hyperlipidemia Tilapia (Oreochromis niloticus)

    Institute of Scientific and Technical Information of China (English)

    沈黄冕; 彭祥和; 林仕梅; 陈拥军; 黄先智

    2016-01-01

    The models of hyperlipidemia tilapia induced by high-fat diet were established to explore the effects of fermented mulberry leaves on serum lipid and blood glucose levels of hyperlipidemia tilapia ( Oreochromis niloticus) . A total of 450 male GIFT tilapia with the initial average body weight of 45 g were randomly divided into 5 groups with 3 replicates per group, and 30 fish in each replicate. The fish in normal control group were fed with a basal diet, and the other 4 groups were fed the basal diet ( model control group) and diets contained 7.5% and 15.0% fermented mulberry leaves ( low level fermented mulberry leaves group and high level fer-mented mulberry leaves group, respectively) , and 0.5% ginkgo flavone ( ginkgo flavone group) after the es-tablishment of the hyperlipidemia model, respectively. The experiment lasted for 8 weeks. The results showed as follows: after feeding 5 and 8 weeks, the body weight in model control group was significantly lower than that in normal control group, low level fermented mulberry leaves group, high level fermented mulberry leaves group and ginkgo flavone group (P0.05) . The serum total cholesterol ( TCHO) and low-density lipoprotein cholesterol ( LDL-C) contents and TCHO/high-density lipoprotein cholesterol ( HDL-C) in low level fermented mulberry leaves group, high level fermented mulberry leaves group and ginkgo fla-vone group were significantly lower than those in model control group (P0.05) . Compared with the model control group, the serum HDL-C content in high level fermented mulberry leaves group and ginkgo flavone group was significantly increased (P0.05). High-fat diet could significantly increase the blood glucose level in model control group, low level fermented mulberry leaves group, high level fermented mulberry leaves group and ginkgo flavone group (0 week, P0.05). These results indicate that fermented mulberry leaves can decrease the serum lipid and blood glucose levels, and enhance the antioxidant ability of

  13. WATER EXTRACT OF SWEET POTATO LEAF IMPROVED LIPID PROFILE AND BLOOD SOD CONTENT OF RATS WITH HIGH CHOLESTEROL DIET

    Directory of Open Access Journals (Sweden)

    I Wayan Sumardika

    2013-04-01

    Full Text Available Food stuffs with high flavonoids content  are believed to prevent various diseases caused by oxidative stress because of its antioxidants effect.  Purple sweet potato leaves have been proved containing high flavonoids, and can be developed very easily. To prove antioxidant and hypolipidemic properties of the water extract of purple sweet potato leaves, one research was conducted in the Department of Pharmacology, Faculty of Medicine, Udayana University. The study design was randomized control group pre- and post-test.  Twenty adult male wistar rats were divided into two groups of 10 rats. Both groups of rats were given high-cholesterol diet for three months to induce dyslipidemia. Control group of 10 rats were given only high-cholesterol diet alone, whereas the treatment group also treated with purple sweet potato leaf water extract with a dose of 6 cc per day divided into two doses. Before treatment and after treatment, lipid profile and blood SOD levels were measured. The results showed a decrease in total cholesterol, triglycerides and LDL cholesterol significantly in the treated group (P = 0.0001. In the treatment group there was also an increase in HDL cholesterol and blood SOD which was significantly differ than the control group (P = 0.0001. From the results of this study, it can be concluded that administration of water extract of purple sweet potato leaves can improve the lipid profile and increase blood SOD of rat given high-cholesterol diet.

  14. Blood antioxidant profile and lipid peroxides in dairy cows with clinical mastitis

    Directory of Open Access Journals (Sweden)

    Rajesh Rathore

    2013-10-01

    Full Text Available Aim: To evaluate blood antioxidant profile and lipid peroxides in dairy cows with clinical mastitis. Materials and Methods: Twelve cases of clinical mastitis in cross-bred cows were selected based on physical examination of udder and milk, California Mastitis Test (CMT, Somatic Cell Count (SCC and confirmation by bacteriological examination of milk and requisite biochemical tests. Twelve lactating cows showing negative CMT reaction and SCC <2x105 cells/ml were considered as healthy control. Antioxidant parameters measured in blood were superoxide dismutase (SOD, catalase activities and reduced glutathione (GSH concentration. Erythrocytic lipid peroxidation (LPO was measured in terms of malondialdehyde (MDA production. Results: Significant (P<0.05 decrease in blood SOD and catalase activities, GSH concentration and an increase in erythrocytic lipid peroxides was observed in cows with clinical mastitis. Conclusion: It is concluded that there is a compromise in antioxidant defense of the body in dairy cows with clinical mastitis resulting in oxidative damage, therefore, necessitate the use of antioxidants and other protective compounds along with conventional therapy for mastitis control. [Vet World 2013; 6(5.000: 271-273

  15. Assessment of persistent organic pollutants levels in blood samples from Quintana Roo, Mexico.

    Science.gov (United States)

    Antonio, Trejo-Acevedo; Edith, Rivero-Pérez Norma; Rogelio, Flores-Ramírez; Fernando, Díaz-Barriga; Catalina, Ochoa Angeles; Nelinho, Pérez-Maldonado Iván

    2013-06-01

    The Stockholm Convention on persistent organic pollutants (POPs) sought to determine baseline exposures to POPs in the general population; however, in developing countries, exposure to these chemicals in hot spots may be an issue of public health considering its magnitude. Therefore, the aim of this study was to assess the levels of POPs in the blood of children living in three communities in the Southeastern Region of Mexico. During 2007, we studied a total of 96 healthy children (aged 6-12 years). Quantitative analyses were performed using gas chromatography coupled with mass spectrometry. High levels of p,p'-DDT and its principal metabolite, p,p'-DDE, were found in the blood of children living in the three communities studied, the levels ranged from 463.5 to 9046.3 ng/g lipid and from 490.8 to 57,712.4 ng/g lipid for DDT and DDE, respectively. In addition, high levels of lindane (γ-HCH) were found, with mean levels ranging between 575.4 and 6580.6 ng/g lipid. Moreover, children living in the study region were also exposed to polychlorinated biphenyls (PCBs), and the levels of these compounds in the blood of children were very similar between the communities with mean levels of around 3000 ng/g lipid (total PCBs). In conclusion, we demonstrated that children living in the studied communities were exposed to complex chemical mixtures (DDT, DDE, lindane and PCBs) rather than to individual compounds. Therefore, in future studies it is important to understand the potential interactions between the components of these mixtures. Copyright © 2012 Elsevier GmbH. All rights reserved.

  16. The effect of resistance exercise on fitness, blood pressure, and blood lipid of hypertensive middle-aged men

    Science.gov (United States)

    Shim, Kyu-Sik; Kim, Jong-Won

    2017-01-01

    The purpose of this study is to investigate the effect of resistance exercise on fitness, blood pressure, and blood lipid of hypertensive middle-aged men. To achieve the goal of the study, a total of 23 subjects were selected. Among them, 14 subjects who exercised regularly were selected as the exercise group, while the remaining 9 subjects were selected as the control group. In terms of data processing, the IBM SPSS Statistics ver. 21.0 software was used to calculate the mean and standard deviation. Regarding the verification of difference on the change of means between the groups, analysis of covariance was used for statistical process. As a result, significant differences were found in cardiovascular endurance, muscle endurance, flexibility, and triglyceride. These results indicate that the resistance exercise only had slight effect on hypertensive middle-aged men.

  17. Effect of EGCG on lipid absorption and plasma lipid levels in rats.

    Science.gov (United States)

    Raederstorff, Daniel G; Schlachter, Manfred F; Elste, Volker; Weber, Peter

    2003-06-01

    Catechins, compounds derived from green tea, have been shown to reduce plasma cholesterol levels and the rate of cholesterol absorption. We investigated the dose response and the mechanism of action of epigallocatechin gallate (EGCG) on these parameters in rats. Wistar rats were fed a diet high in cholesterol and fat containing either none, 0.25% (0.2 g/day/kg BW), 0.5% (0.4 g/day/kg/BW) or 1.0% (0.7 g/day/kg BW) of EGCG. After 4 weeks of treatment, total cholesterol and low density lipoprotein plasma levels were significantly reduced in the group fed 1% EGCG when compared to the no treatment group. Plasma triglycerides and high-density lipoprotein levels did not change significantly. Following a single oral application of a liquid test-meal, intestinal cholesterol absorption in Wistar rats was 79.3% in the control group. In the group treated with 0.1 g/kg BW EGCG intestinal cholesterol absorption decreased to 73.7% and in the group treated with 0.5 g/kg BW of EGCG intestinal cholesterol absorption fell significantly to 62.7% (P = 0.005). Total fat absorption was very efficient in the control group (99.5% of the applied dose) and decreased significantly but moderately in the group treated with the highest doses of EGCG (0.75, 1 g/kg BW). In an in-vitro biliary micelle model, the addition of 55 microM to 1300 microM EGCG not only decreased cholesterol solubility dose-dependently in these micelles but also altered the size of the mixed lecithin/taurocholate/cholesterol micelles as demonstrated by light scattering. This study provides evidence suggesting that the cholesterol-lowering effect of green tea is mainly elicited by EGCG, one of the most abundant catechins contained in green tea. It is suggested that one of the underlying mechanisms by which EGCG affects lipid metabolism is by interfering with the micellar solubilization of cholesterol in the digestive tract, which then in turn decreased cholesterol absorption.

  18. The Effects of Soy Protein and Isoflavones on Lipid Oxidation and Blood Lipid Profile on Humans Participating in Moderate Physical Activity

    OpenAIRE

    Shehadeh, Sandra C

    1999-01-01

    THE EFFECTS OF SOY PROTEIN AND ISOFLAVONES ON LIPID OXIDATION AND BLOOD LIPID PROFILE ON HUMANS PARTICIPATING IN MODERATE PHYSICAL ACTIVITY Sandra C. Shehadeh The purpose of our study was to compare the effects of dietary soy protein and animal protein (casein) on plasma lipoprotein concentrations, and exercise induced oxidation in human subjects. Sixteen normocholesterolemic young men participated in 30 min of cycling at 70% VO2pk to induce plasma oxidation. Each subject then followe...

  19. Effect of Cucurbita ficifolia and Probiotic Yogurt Consumption on Blood Glucose, Lipid Profile, and Inflammatory Marker in Type 2 Diabetes

    Science.gov (United States)

    Bayat, Azade; Azizi-Soleiman, Fatemeh; Heidari-Beni, Motahar; Feizi, Awat; Iraj, Bijan; Ghiasvand, Reza; Askari, Gholamreza

    2016-01-01

    Background: Control of blood sugar, hypertension, and dyslipidemia are key factors in diabetes management. Cucurbita ficifolia (pumpkin) is a vegetable which has been used traditionally as a remedy for diabetes in Iran. In addition, consumption of probiotics may have beneficial effects on people with Type 2 diabetes. The aim of this study was an investigation of the effects of C. ficifolia and probiotic yogurt consumption alone or at the same time on blood glucose and serum lipids in diabetic patients. Methods: Eighty eligible participants randomly were assigned to four groups: 1 - green C. ficifolia (100 g); 2 - probiotic yogurt (150 g); 3 - C. ficifolia plus probiotic yogurt (100 g C. ficifolia plus 150 g yogurt); and 4 -control (dietary advice) for 8 weeks. Blood pressure, glycemic response, lipid profile, and high-sensitive C-reactive protein (hsCRP) were measured before and after the intervention. Results: Total cholesterol (TC) decreased significantly in yogurt and yogurt plus C. ficifolia groups (within groups P = 0.010, and P < 0.001, respectively). C. ficifolia plus yogurt consumption resulted in a decrease in triglyceride (TG) and an increase in high-density lipoprotein cholesterol (HDL-C) (within groups P < 0.001 and P = 0.001, respectively). All interventions led to a significant decrease in blood sugar, hemoglobin A1c (HbA1c), hsCRP, and low-density lipoprotein cholesterol (LDL-C) level within groups. Blood pressure decreased significantly in Cucurbita group and yogurt group (within groups P < 0.001, and P = 0.001 for systolic blood pressure [SBP] and P < 0.001, and P = 0.004 for diastolic blood pressure [DBP], respectively). All variables changed between groups significantly except LDL-C level. Conclusions: Variables including TG, HDL-C, TC, fasting blood sugar, HbA1c, SBP, DBP, and hsCRP changed beneficially between groups. It seems that consumption of C. ficifolia and probiotic yogurt may help treatment of diabetic patients. PMID:26955460

  20. Assessment of the levels of polybrominated diphenyl ethers in blood samples from Guadalajara, Jalisco, Mexico.

    Science.gov (United States)

    Orta-Garcia, Sandra Teresa; León-Moreno, Lilia Carolina; González-Vega, Carolina; Dominguez-Cortinas, Gabriela; Espinosa-Reyes, Guillermo; Pérez-Maldonado, Iván N

    2012-10-01

    The purpose of this study was to measure levels of polybrominated diphenyl ethers (PBDEs) in the blood of children (50 individuals) living in Guadalajara, Jalisco, Mexico. We analyzed six PBDE congeners by gas chromatography-mass spectrometry. Total PBDE levels ranged from not detectable (nd) to 15.2 μg/L on a whole-weight basis and from nd to 6,435 ng/g lipid on a lipid-weight basis. The dominant congener in our study was BDE-153, followed by BDE-154, BDE-99, BDE-100, and BDE-47. Levels of BDE-209 were below the detection limit. Our data indicate that children living in the areas studied in this work are exposed to high levels of PBDEs.

  1. Blood and milk lipid responses induced by growth hormone administration in lactating cows.

    Science.gov (United States)

    Bitman, J; Wood, D L; Tyrrell, H F; Bauman, D E; Peel, C J; Brown, A C; Reynolds, P J

    1984-12-01

    Nine multiparous Holstein cows (average 5.8 yr, 63 to 132 days postpartum) were in a 28-day single reversal experiment in the Beltsville open circuit respiration chambers with two 14-day injection periods (placebo versus bovine growth hormone, 51.5 IU/day). With growth hormone treatment, milk fat percentage increased 25 to 29%, milk fat yield increased 41%, and cows averaged -13.7 Mcal/day energy balance. There were small increases of triglycerides and 1,2-diglycerides, core lipids, and small decreases of cholesterol and phospholipids, the membrane lipids. Fat from growth hormone treatment had 6% less short (6:0, 8:0, 10:0) and medium (12:0, 14:0, 14:1, 15:0, 16:0) chain fatty acids and 6% more long chain 18:1 fatty acids. Plasma of cows treated with growth hormone had an increase of concentrations of free fatty acids, but no shifts were apparent among other lipid classes. Analysis of total plasma fatty acids did not show any net changes, but within individual plasma lipid classes, 18:1 increased and 18:2 decreased. Overall changes of blood and milk lipids are consistent with the concept that adipose tissue reserves were mobilized in response to hormone treatment and that these mobilized lipids were the major carbon source for the 41% increase of milk fat secretion. Increases of de novo synthesis of short and medium chain fatty acids also occurred but much less. Cows treated with growth hormone were in negative energy balance, and the mechanism may differ when cows are in positive energy balance.

  2. Blood lead levels in preschool children in Cape Town

    Energy Technology Data Exchange (ETDEWEB)

    Deveaux, P.; Kibel, M.A.; Dempster, W.S.; Pocock, F.; Formenti, K.

    1986-03-29

    Blood lead levels were assessed in 293 children aged between 4 and 6 years attending preschool centers in metropolitan Cape Town in order to establish the degree of lead absorption. Anthropometric data, blood count, zinc protoporphyrin and blood lead level were obtained for each child. A questionnaire was used to determine socio-economic status, dietary habits and history of pica. Thirteen children, or 4,4% of those sampled, had blood levels of greater than or equal to 30 micrograms/dl. The majority of these children lived in close proximity to one another in a socially deprived inner urban environment. Environmental sampling for lead was carried out in the homes of children with the highest blood levels as well as in the homes of a matched control group with low levels living in the same area. The only difference was a significantly higher incidence of pica in the children with high levels.

  3. The Effects of 8-Weeks Aerobic Exercise Program on Blood Lipids and Cholesterol Profile of Smokers vs. Non Smokers

    Science.gov (United States)

    Taifour, Akef; AL-Shishani, Ahmad; Khasawneh, Aman; AL-Nawaiseh, Ali; Bakeer, Mohammed

    2015-01-01

    The aim of this study was to compare the effects of 8-week aerobic exercise program on blood lipids and cholesterol profile of smoker's vs. non-smokers. A total of 34 male subjects (18 non-smokers and 16 smokers) took part in this study. Both groups were pre- and post tested in their blood-lipids and cholesterol profile before and after the 8-week…

  4. Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial

    DEFF Research Database (Denmark)

    Sever, Peter; Dahlöf, Björn; Poulter, Neil;

    2006-01-01

    A prespecified objective of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) was to assess whether any synergistic effects were apparent between the lipid-lowering and blood-pressure-lowering regimens in preventing cardiovascular events.......A prespecified objective of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) was to assess whether any synergistic effects were apparent between the lipid-lowering and blood-pressure-lowering regimens in preventing cardiovascular events....

  5. Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia.

    Science.gov (United States)

    Stelmach, M J; Wasilewska, N; Wicklund-Liland, L I; Wasilewska, A

    2015-06-01

    Numerous studies have demonstrated that elevated serum uric acid concentration (SUA) is correlated with lipid profile in hypertensive or obese patients. However, the relationship between serum uric acid levels and lipid profile in non-obese late adolescent population was not examined before. In this study we decided to assess the potential relationship between SUA and lipid profile, according to gender in adolescents with HU. The study group comprises 607 Polish adolescents (474 males, 133 females) with HU. Retrospective analysis included demographic, clinical, and laboratory data. Lipid profile was assessed including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol to HDL-C ratio (TC/HDL-C). In the examined group 187/607 (31%) of teenagers were diagnosed with metabolic syndrome (MetS). Median BMI-Z-score was 1.11 Q1-Q3: (-0.02-2.03) and both females and males in the upper tertile of SUA had statistically significant higher BMI-Z-score. The males in the upper tertile of serum uric acid levels also had higher values of TG and lower of HDL-C. In females, we have not found significant differences in lipid profile. Multiple regression analyses indicated that male gender, BMI-Z-score, and presence of hypertension correlated significantly with serum uric acid concentration. In summary, the results of our study confirm higher prevalence of hyperuricemia in males when compared to females and a stronger association of HU with BMI-Z-score and lipid profile in male adolescents. Nevertheless, multiple regression does not confirm the independent association of SUA with lipid profile.

  6. Impact of Diet Containing Grape Pomace on Growth Performance and Blood Lipid Profile of Young Rats.

    Science.gov (United States)

    Smith, Ivy; Yu, Jianmei; Hurley, Steven L; Hanner, Tracy

    2017-06-01

    Grape pomace (GP), the residue of grapes after wine making, is rich in dietary polyphenols and fiber, and it has potential to serve as a functional food ingredient to improve health. However, high polyphenol diets have also been reported to inhibit the growth of young animals and cause liver necrosis. This study investigated the effect of diets containing different amounts of GP on the growth performance and blood lipid profile by using a young rat model. Twenty female Sprague-Dawley rats of age 7 weeks were randomly divided into four groups that were fed AIN-93G diets that were modified by substituting 0%, 10%, 20%, and 30% of carbohydrate with GP for 10 weeks (the diets, thus, obtained contained 0%, 6.9%, 13.8%, and 20.7% of GP). The group fed original AIN-93G (0% GP) was used as control. Feed consumption, body weight, length, and height were recorded weekly. Blood samples were taken biweekly to analyze plasma lipid profile. At the end of the feeding period, the rats were fasted overnight and euthanized by exsanguination under anesthesia. Livers, hearts, and kidneys were collected, and their weights were recorded. Results show that the diet containing a maximum of 20.7% of GP did not influence the body weights, lengths, and heights of rats. As the GP content increased, the blood triglyceride and very low-density lipoproteins (VLDL) decreased, the high-density lipoprotein (HDL) and low-density lipoprotein (LDL) increased slightly but were statistically significant, and total cholesterol remained constant. In conclusion, GP in the AIN-93G diet did not influence the growth performance of young rats, but it exhibited both positive and negative effects on the blood lipid profile.

  7. Effect of Tai Chi exercise on blood lipid profiles:a meta-analysis of randomized controlled trials

    Institute of Scientific and Technical Information of China (English)

    Xiao-hong PAN; Amina MAHEMUTI; Xue-hua ZHANG; Ya-ping WANG; Po HU; Ju-bo JIANG; Mei-xiang XIANG; Gang LIU; Jian-an WANG

    2016-01-01

    题目:太极锻炼对血脂的临床疗效:随机对照试验的meta分析目的:探讨太极锻炼是否能改善血脂水平。创新点:明确太极锻炼对血脂的影响,为非药物调脂治疗提供新手段。方法:通过筛选太极锻炼持续4周以上,PEDro评分3分以上,且观察太极锻炼对血脂影响的成人随机对照试验,meta分析太极锻炼对总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的影响。结论:通过meta分析最终入选的6项研究(共445例患者)的结果显示,太极锻炼能显著降低血甘油三酯水平,且有降低总胆固醇的趋势,但是对于低密度脂蛋白胆固醇和高密度脂蛋白胆固醇未发现有明显影响。%Objective: Studies have demonstrated that Tai Chi exercise improves blood lipid level with inconsistent results. A meta-analysis was conducted to quantify the effects of Tai Chi on blood lipid profiles in humans. Methods: We screened the databases of PubMed, EMBASE, Cochrane Library (Central), Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang data, and Clinicaltrials.gov for randomized controlled trials with Physio-therapy Evidence Database (PEDro) score more than 3 points up to June 2015. Six studies involving 445 subjects were included. Most trials applied 12-week Tai Chi intervention courses. Results: In comparison with the control group, blood triglyceride (TG) level difference between folow-up and baseline was statisticaly significantly lower in the Tai Chi practicing group (weighted mean difference (WMD)−16.81 mg/dl; 95% confidence intervals (CI)−31.27 to−2.35 mg/dl;P=0.02). A trend to improving total cholesterol (TC) reduction was found with Tai Chi (WMD−7.96 mg/dl; 95% CI−17.30 to 1.39 mg/dl;P=0.10). However, no difference was found in blood low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C). Conclusions: Tai Chi exercise lowered

  8. Does Ramadan fasting alter body weight and blood lipids and fasting blood glucose in a healthy population? A meta-analysis.

    Science.gov (United States)

    Kul, Seval; Savaş, Esen; Öztürk, Zeynel Abidin; Karadağ, Gülendam

    2014-06-01

    In this study, we conducted a meta-analysis of self-controlled cohort studies comparing body weights, blood levels of lipids and fasting blood glucose levels before and after Ramadan taking into account gender differences. Several databases were searched up to June 2012 for studies showing an effect of Ramadan fasting in healthy subjects, yielding 30 articles. The primary finding of this meta-analysis was that after Ramadan fasting, low-density lipoprotein (SMD = -1.67, 95 % CI = -2.48 to -0.86) and fasting blood glucose levels (SMD = -1.10, 95 % CI = -1.62 to -0.58) were decreased in both sex groups and also in the entire group compared to levels prior to Ramadan. In addition, in the female subgroup, body weight (SMD = -0.04, 95 % CI = -0.20, 0.12), total cholesterol (SMD = 0.05, 95 % CI = -0.51 to 0.60), and triglyceride levels (SMD = 0.03, 95 % CI = -0.31, 0.36) remained unchanged, while HDL levels (SMD = 0.86, 95 % CI = 0.11 to 1.61, p = 0.03) were increased. In males, Ramadan fasting resulted in weight loss (SMD = -0.24, 95 % CI = -0.36, -0.12, p = 0.001). Also, a substantial reduction in total cholesterol (SMD = -0.44, 95 % CI = -0.77 to -0.11) and LDL levels (SMD = -2.22, 95 % CI = -3.47 to -0.96) and a small decrease in triglyceride levels (SMD = -0.35, 95 % CI = -0.67 to -0.02) were observed in males. In conclusion, by looking at this data, it is evident that Ramadan fasting can effectively change body weight and some biochemical parameters in healthy subjects especially in males compared to pre-Ramadan period.

  9. Whole blood viscosity issues VI: Association with blood salicylate level and gastrointestinal bleeding

    Directory of Open Access Journals (Sweden)

    Ezekiel Uba Nwose

    2010-01-01

    Full Text Available Background : This series on whole blood viscosity issues has been trying to elucidate the sensitivity, specificity and usefulness of the laboratory parameter in clinical practice. The postulation has been that since antiplatelet is used in the management of stasis, of which blood viscosity is an index, the latter would be useful laboratory indication and/or contraindication. Aim : The aim of this study was to observe whether blood level of acetylsalicylic acid differs with the level of whole blood viscosity. Patients and Methods : Out of the ten years database, 538 cases that were concomitantly tested for haematocrit, total proteins and blood level of salicylate were selected for this study. A separate nine cases of positive faecal occult blood tests were audited for blood viscosity and reviewed. Results : A statistically significant difference is observed with lower blood viscosity being associated with higher salicylate level in comparison of the former between the highest vs. lowest quartiles (p < 0.002. This observation demonstrates the effect of aspirin in lowering blood stasis. Reviewing the positive faecal occult blood cases indicate that gastrointestinal bleeding is characterized by relative hypoviscosity and that hyperviscosity is not present during bleeding complications. Conclusion : The findings affirm that whole blood viscosity is a valid clinical laboratory parameter for evidence-based contraindication, indication and monitoring of antiplatelet medication. It calls for better appreciation and clinical utility of whole blood viscosity, which (in the absence of viscometer can now be extrapolated from haematocrit and total proteins.

  10. A long-term follow-up study of serum lipid levels and coronary heart disease in the elderly

    Institute of Scientific and Technical Information of China (English)

    李健斋; 陈曼丽; 王抒; 董军; 曾平; 侯鲁维

    2004-01-01

    Background It is still controversial whether or not the correlation between lipid abnormality and coronary heart disease (CHD) becomes weaker in the elderly, and whether patients above 80 years old still benefit from lipid management for the secondary prevention of CHD. The purpose of this study is to assess the correlation between hyperlipidemia and the risk of CHD events in the elderly, and to determine if it is appropriate to use lipid-lowering drugs in those aged above 80, as prescribed by the recommended guidelines for lipid management.Methods One thousand two hundred and eleven retirees, mainly males (92%), aged 70±9 years, were enrolled in this study. Lifestyle habits and medical history were recorded via questionnaires. During the period 1986 -2000, all subjects participated in an annual physical examination with a blood chemistry survey. The mean follow-up period was 11.2 years. Subjects with incidental illnesses, especially cardiovascular diseases, were diagnosed or treated promptly. Serum lipid parameters, including total cholesterol (TC), Iow and high-density lipoprotein cholesterol (LDL-C and HDL-C) and triglyceride (TG) levels were analyzed according to standardization of lipid and lipoprotein measurements. The association between lipid levels and the prevalence of acute myocardial infarction (AMI) or coronary death was analyzed statistically. Results Lipid abnormalities occurred in 2/3 of the 1211 subjects. The most common lipid disorder was high TC and high LDL-C, which was much more prevalent than high TG. Among the subjects, 51.6% had TC levels above 5.2 mmol/L. Mean TC and LDL-C reached peak levels in the 65-74 age group without significant decrease until ages over 90. The cumulative total number of deaths due to various causes was 397 in the 15-year follow-up period, with the mortality rate in the high lipid group slightly lower than that in the normal lipid group (30.6% vs 35. 3% ), although the difference was not significant (P=0

  11. Effect of honey vinegar syrup on blood sugar and lipid profile in healthy subjects

    Directory of Open Access Journals (Sweden)

    Seyedeh-Masomeh Derakhshandeh-Rishehri

    2014-01-01

    Full Text Available Background: The impact of honey or vinegar on several metabolic abnormalities has been studied separately, a mixture of these two ingredients known as honey vinegar syrup (HVS has not been investigated previously so far. The aim of this study was to assess the impact of HVS consumption (Iranian′s traditional syrup on glycemic parameters and lipid profiles in healthy individuals. Methods: We conducted a 4-week, randomized, controlled, parallel study consisting of two groups of nonobese healthy volunteers. All subjects were asked to stay on their normal diet. Intervention group (n = 36 received a cup of HVS daily in the evening snack for 4-week (250 cc syrup contains 21.66 g honey vinegar. Assessments of fasting blood sugar (FBS, insulin, homeostasis model assessment of insulin resistance (HOMA-IR, total cholesterol (TC, triglyceride (TG, high-density lipoprotein cholesterol (HDL-C and low-density lipoprotein cholesterol (LDL-C were conducted at the baseline and after 4-week of study. Results: We observed no significant effect of HVS on FBS, HOMA-IR, LDL-C and TG. A significant effect of HVS was found on increasing fasting insulin and HOMA-IR and reduction in TC level only in intervention group (Δ =3.39 P = 0.01, Δ =1.65 P = 0.03, Δ = −9.43 P = 0.005, respectively. Changes of FBS, TG and LDL-C were 1.83 mg/dl, −1.53 mg/dl and − 3.99 mg/dl respectively in the intervention group. These changes were not significant. An unfavorable and significant reduction in HDL-C level was also observed between two groups (Δ = −4.82 P < 0.001 in the intervention group. Conclusions: Honey vinegar syrup increased fasting insulin level and decreased TC level in the intervention group. HVS had an unfavorable effect on HDL-C level. Further prospective investigations are warranted to confirm these findings.

  12. Effect of Honey Vinegar Syrup on Blood Sugar and Lipid Profile in Healthy Subjects

    Science.gov (United States)

    Derakhshandeh-Rishehri, Seyedeh-Masomeh; Heidari-Beni, Motahar; Feizi, Awat; Askari, Gholam-Reza; Entezari, Mohammad-Hassan

    2014-01-01

    Background: The impact of honey or vinegar on several metabolic abnormalities has been studied separately, a mixture of these two ingredients known as honey vinegar syrup (HVS) has not been investigated previously so far. The aim of this study was to assess the impact of HVS consumption (Iranian's traditional syrup) on glycemic parameters and lipid profiles in healthy individuals. Methods: We conducted a 4-week, randomized, controlled, parallel study consisting of two groups of nonobese healthy volunteers. All subjects were asked to stay on their normal diet. Intervention group (n = 36) received a cup of HVS daily in the evening snack for 4-week (250 cc syrup contains 21.66 g honey vinegar). Assessments of fasting blood sugar (FBS), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were conducted at the baseline and after 4-week of study. Results: We observed no significant effect of HVS on FBS, HOMA-IR, LDL-C and TG. A significant effect of HVS was found on increasing fasting insulin and HOMA-IR and reduction in TC level only in intervention group (Δ =3.39 P = 0.01, Δ =1.65 P = 0.03, Δ = −9.43 P = 0.005, respectively). Changes of FBS, TG and LDL-C were 1.83 mg/dl, −1.53 mg/dl and − 3.99 mg/dl respectively in the intervention group. These changes were not significant. An unfavorable and significant reduction in HDL-C level was also observed between two groups (Δ = −4.82 P < 0.001 in the intervention group). Conclusions: Honey vinegar syrup increased fasting insulin level and decreased TC level in the intervention group. HVS had an unfavorable effect on HDL-C level. Further prospective investigations are warranted to confirm these findings. PMID:25709798

  13. Study on the Correlation between Chinese Medicine Syndrome Types of the Uighur and Han People and Levels of Blood Lipids and Fibrinogen in Premature Coronary Heart Disease Patients%维吾尔族与汉族早发冠心病患者中医证型与血脂及纤维蛋白原相关性研究

    Institute of Scientific and Technical Information of China (English)

    翟雪芹; 刘浩; 王晓峰

    2012-01-01

    异均有统计学意义(P <0.01,P<0.05).结论 维族、汉族PCHD患者中医证型与TG、HDL-C及FIB存在相关性.%Objective To study the correlation between the Chinese medicine (CM) syndrome types of the Uighur and Han people and levels of blood lipids and fibrinogen in premature coronaiy heart disease (PCHD) patients. Methods Recruited were 196 Uighur and 189 Han patients with PCHD first confirmed by coronary angi-ography at the Heart Center of First Affiliated Hospital of Xinjiang Medical University and Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University. Another 60 healthy volunteers were recruited as the healthy control group. CM syndromes were typed by physicians or those having higher professional titles at the cadiac internal medicine. The contents of triglyceride (TG) and total cholesterol (TC) were detected using oxidase method. The high-density lipoprotein cholesterol (HDL-C) level was detected using chemical modification enzymic method. The low-density lipoprotein cholesterol (LDL-C) level was detected using selective dissolution. The fibrinogen (FIB) level was detected using Clauss congeal principle. Results The CM syndrome types of Uighurs were sequenced as filthy turbidity and phlegm obstruction syndrome (82 cases, 21.3%) >qi deficiency and blood stasis syndrome (61 cases, 15.84%) >cold accumulation in Xin meridian syndrome (39 cases, 10.13%) >Xin- Shen yin deficiency syndrome (14 cases, 3.63%). The CM syndrome types of the Han nationality were se-quenced as qi deficiency and blood stasis syndrome (69 cases, 17.92%) >filthy turbidity and phlegm obstruction syndrome (67 cases, 17. 40%) >cold accumulation in Xin meridian syndrome (42 cases, 10. 91%) >Xin-Shen yin deficiency syndrome (11 cases, 2.86%). There was no statistical difference in the syndrome type distribution between the two groups (P>0.05). Compared with the healthy control group, the levels of TG, LDL-C, and FIB increased, and the HDL-C level decreased in patients of filthy

  14. Effects of different doses of testosterone on gonadotropins, 25-hydroxyvitamin D3, and blood lipids in healthy men

    Directory of Open Access Journals (Sweden)

    Gårevik N

    2014-12-01

    Full Text Available Nina Gårevik, Anders Rane, Linda Björkhem-Bergman, Lena Ekström Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Aims: To study the effect and time profile of different doses of testosterone enanthate on the blood lipid profile and gonadotropins. Experimental design: Twenty-five healthy male volunteers aged 27–43 years were given 500 mg, 250 mg, and 125 mg of testosterone enanthate as single intramuscular doses of Testoviron® Depot. Luteinizing hormone (LH, follicle-stimulating hormone (FSH, blood lipid profile (total cholesterol, plasma [p-] low-density lipoprotein, p-high-density lipoprotein [HDL], p-apolipoprotein A1 [ApoA1], p-apolipoprotein B, p-triglycerides, p-lipoprotein(a, serum [s-] testosterone, and 25-hydroxyvitamin D3 were analyzed prior to, and 4 and 14 days after dosing. Testosterone and epitestosterone in urine (testosterone/epitestosterone ratio were analyzed prior to each dose after a washout period of 6–8 weeks. Results and discussion: All doses investigated suppressed the LH and FSH concentrations in serum. LH remained suppressed 6 weeks after the 500 mg dose. These results indicate that testosterone has a more profound endocrine effect on the hypothalamic–pituitary–gonadal axis than was previously thought. There was no alteration in 25-hydroxyvitamin D3 levels after testosterone administration compared to baseline levels. The 250 and 500 mg doses induced decreased concentrations of ApoA1 and HDL, whereas the lowest dose (125 mg did not have any effect on the lipid profile. Conclusion: The single doses of testosterone produced a dose-dependent increase in serum testosterone concentrations together with suppression of s-LH and s-FSH. Alterations in ApoA1 and HDL were observed after the two highest single doses. It is possible that long-time abuse of anabolic androgenic steroids will lead to alteration in vitamin D status

  15. Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels.

    Science.gov (United States)

    Ramos, O; Carrizales, L; Yáñez, L; Mejía, J; Batres, L; Ortíz, D; Díaz-Barriga, F

    1995-01-01

    The role of lipid peroxidation in the mechanism of arsenic toxicity was investigated in female rats pretreated with N-acetylcysteine (NAC, a glutathione [GSH] inducer) or with buthionine sulfoximine (BSO, a GSH depletor). Rats were challenged with sodium arsenite, and sacrificed 1 hr after this treatment. Results showed that arsenic decreased GSH levels and increased lipid peroxidation in liver, kidney, and heart, with a larger effect at 18.2 mg/kg than at 14.8 mg/kg for lipid peroxidation induction. In the liver of rats treated with arsenic, pretreatment with NAC increased the levels of GSH and decreased lipid peroxidation. In kidney and heart, NAC pretreatment protected the tissues against arsenic-induced depletion of GSH levels, but the same degree of protection was not found for lipid peroxidation induction. In its turn, BSO had an additive effect with arsenic in lowering the levels of GSH in the liver and kidney, but an inverse correlation between GSH levels and lipid peroxidation was found only in liver. Arsenic content in tissues of rats pretreated with NAC was lower than in rats treated only with arsenic. In rats with depleted levels of GSH (BSO-pretreated rats), a shift in arsenic tissue distribution was found, with higher levels in skin and lower levels in kidney. A clear tendency for a positive correlation between arsenic concentration and lipid peroxidation levels was found in liver, kidney, and heart. PMID:7621808

  16. 生长激素和性激素对健康女性胰岛素和血脂水平的影响%Effects of growth hormone and sex hormones on insulin and blood lipid levels in healthy women

    Institute of Scientific and Technical Information of China (English)

    惠月红; 石莹

    2015-01-01

    Objective:To explore the effects of growth hormone and sex hormones on insulin and blood lipid levels in healthy women,provide reference for further researches and experiments.Methods:Eighty-six healthy adult women were randomly selected and divided into experimental group and control group according to the principle of voluntariness,43 women in each group.The women in experimental group were intervened by growth hormone and sex hormones for 12 weeks,while the women in control group were not treated with any hormone ; dietary structures in the two groups were the same,the women in the two groups were not treated with other drugs; the levels of insulin and blood lipid in the two groups were compared.Results:The levels of insulin in experimental group and control group were 134.8 pmol/L and 109.3 pmol/L,respectively,there was statistically significant difference between the two groups (P <0.05) ; the levels of low density lipoprotein,total cholesterol,and triglyceride were 1.48 mmol/L,3.89 mmol/L,1.48 mmol/L in experimental group and 2.75 mmol/L,4.10 mmol/L,1.31 mmol/L in control group,there was statistically significant difference in low density lipoprotein level between the two groups (P < 0.05),but there was no statistically significant difference in levels of total cholesterol and triglyceride between the two groups (P > 0.05).Conclusion:Low-density lipoprotein level decreases after intervention with growth hormone and sex hormones,but the levels of total cholesterol and triglyceride do not change significantly.Long-term application in healthy women can reserve insulin sensitivity,which is of great significance for preventing diabetes.%目的:探讨生长激素和性激素对健康女性胰岛素和血脂水平的影响,为以后相关研究提供参考.方法:从社会上以有偿的方式随机征召86名成年健康女性为参与者,根据自愿原则分为实验组和对照组,每组43名.实验组使用生长激素及性激素进行干预,对照组

  17. Pre-pregnancy weight status, early pregnancy lipid profile and blood pressure course during pregnancy: The ABCD study.

    Science.gov (United States)

    Oostvogels, Adriëtte J J M; Busschers, Wim B; Spierings, Eline J M; Roseboom, Tessa J; Gademan, Maaike G J; Vrijkotte, Tanja G M

    2017-01-01

    Although pre-pregnancy weight status and early pregnancy lipid profile are known to influence blood pressure course during pregnancy, little is known about how these two factors interact. The association between pre-pregnancy weight status and blood pressure course during pregnancy was assessed in the prospective ABCD study and the role (independent/mediating/moderating) of early pregnancy lipid profile in this association was determined. We included 2500 normal weight (lipids [median (IQR): 13 (12-14) weeks of gestation] and blood pressure during pregnancy [mean (SD) = 10 (2.3)]. Lipids (triglycerides, total cholesterol, apolipoprotein A1, apolipoprotein B and free fatty acids) were divided into tertiles. Multilevel piecewise linear spline models were used to describe the course of systolic and diastolic blood pressure (SBP/DBP) in four time periods during gestation for overweight and normal weight women. Both SBP (5.3 mmHg) and DBP (3.9 mmHg) were higher in overweight compared to normal weight women and this difference remained the same over all four time periods. The difference in SBP and DBP was not mediated or moderated by the lipid profile. Lipid profile had an independent positive effect on both SBP (range 1.3-2.2 mmHg) and DBP (0.8-1.1 mmHg), but did not change blood pressure course. Both pre-pregnancy weight status and early pregnancy lipid profile independently increase blood pressure during pregnancy. Improving pre-pregnancy weight status and early pregnancy lipid profile might result in a healthier blood pressure course during pregnancy.

  18. Hábito alimentar, níveis de lipídios sangüíneos e o status antioxidante de adultos jovens fumantes e não fumantes Food habits, blood lipid levels and antioxidant status of young adults smokers and non-smokers

    Directory of Open Access Journals (Sweden)

    Ellencristina da Silva Batista

    2009-06-01

    Full Text Available OBJETIVO: Avaliar o hábito alimentar, os níveis dos lipídios sangüíneos e o status antioxidante de jovens fumantes e não fumantes. MÉTODOS: Trata-se de um estudo transversal em que 68 indivíduos, de 18 a 26 anos, emparelhados por sexo e idade, foram divididos em dois grupos: fumantes (n=34 e não fumantes (n=34. Os voluntários selecionados em instituições de ensino, em Viçosa (MG foram questionados quanto a: hábito de fumar, consumo de bebidas alcoólicas e atividade física; também foi estimada a dependência nicotínica. O hábito alimentar foi avaliado por questionário de freqüência de consumo. Quantificaram-se níveis séricos de lipídios, nível plasmático de malondialdeído, vitamina E e vitamina C. RESULTADOS: Os jovens começaram a fumar precocemente, independentemente do sexo. O hábito de fumar foi estratificado e encontrou-se 58,8% de fumantes leves e 41,2% de fumantes pesados. Os fumantes apresentaram hábitos alimentares inadequados e consumo freqüente de bebida alcoólica. De acordo com a recomendação do International Physical Activity Questionnaire 69% dos fumantes eram ativos e 27,6% eram muito ativos. Não se observou diferença significante na concentração sérica de lipídios entre fumantes e não fumantes. No grupo de fumantes mulheres, verificou-se correlação positiva entre o número de cigarros fumados por dia e os triglicerídeos séricos (r=0,824 e p=0,0001 e também entre o tempo que fumavam em anos e o nível de colesterol total (r=0,523 e p=0,031. Os fumantes apresentaram concentração inferior de vitaminas E e C (p=0,002 e p=OBJECTIVE: The objective was to evaluate the food habits, blood lipid levels and antioxidant status of young adult smokers and non smokers. METHODS: This cross-sectional study divided 68 individuals aged 18 to 26 years, matched for age and sex, into two groups: smokers (n=34 and non-smokers (n=34. The individuals, selected from schools in Viçosa (MG, were asked about

  19. Meta analysis:influence of Ginkgo biloba extract in combination with statins treatment on blood lipid levels in patients with hyperlipidemia%银杏叶制剂联合他汀类药物对高脂血症患者血脂水平影响的Meta分析

    Institute of Scientific and Technical Information of China (English)

    陈盼盼; 李晓艳; 刘杨; 李君

    2014-01-01

    Objective To systematically evaluate the influence of Ginkgo biloba extract (GBE) in combina-tion with statins treatment on blood lipid levels in patients with hyperlipidemia. Methods MEDLINE, EMbase, CENTRAL, Ovid, Wanfang Data, VIP, CNKI and CBM were searched for researches of Randomized Controlled Trials (RCTs) on GBE in combination with statins treatment in patients with hyperlipidemia, with time limited from the data-bases' establishment dates to December 2012. The bibliographies of the included researches were searched as well. Evaluated the included researches basing on the GRADE system, then performed Meta-analysis on the qualified re-searches by adopting RevMan 5.1. Results There was no relevant foreign research since GBE belongs to Chinese medicine. Therefore nine articles were included, with a total of 798 cases. In these researches, patients in the control group were treated with just statins, while patients in the experimental group were treated with statins and GBE. The result of Meta analysis showed that there were statistically significant differences between the lipid levels (TC, TG, LDL-C, HDL-C) of experimental group and those of the control group after treatment [WMD (95%CI) were respec-tively-0.39(-0.49,-0.29),-0.06(-0.08,-0.05),-0.26(-0.34,-0.17), and 0.19(0.16, 0.23)]. Conclusion The Ginkgo biloba extract in combination with statins treatment for hyperlipidemia can significantly reduce the patients' blood lip-id levels, and it had a better clinical effect than that of the statins only treatment.%目的:系统评价银杏叶制剂联合他汀类药物对高脂血症患者血脂水平的影响。方法计算机检索MEDLINE、EMbase、Cochrane Central Register of Controlled Trials (CENTRAL)、Ovid、万方数据库(Wanfang Data)、维普数据库(VlP)、中国知网(CNKI)和中国生物医学文献数据库(CBM)中关于银杏叶制剂联合他汀类药物协同作用于高脂血症患者的研究,同时追索纳入其参考文献。

  20. Dietary canola oil alters hematological indices and blood lipids in neonatal piglets fed formula.

    Science.gov (United States)

    Innis, S M; Dyer, R A

    1999-07-01

    This study was undertaken to determine the effects of canola oil on platelet characteristics, blood lipids and growth in exclusively formula-fed piglets. Piglets were fed from birth to 10 or 18 d with formula containing 51% energy from fat, with 100% fat as canola or soybean oil; 26% soybean, 59% high oleic acid sunflower and 12% flax oil (canola mimic); or 26% canola (canola blend) or soybean (soybean blend) with high oleic acid sunflower, palm and coconut oil. The canola mimic provided similar carbon chain 16 and 18 fatty acids without the sterol or 20:1 and erucic acid (22:1) of canola oil. The oil blends provided formula resembling infant formulas but with higher 16:0 and lower unsaturated fatty acid levels than in canola or soybean oil. Body weight, weight gain and heart and liver weight were not different after 10 or 18 d feeding canola when compared to soybean oil alone or blended oil formulas. Piglets fed formulas with 100% canola oil had lower platelet counts than piglets fed formula soybean oil or the canola oil mimic. Platelet counts were lower, and platelet distribution width and volume were higher, when formulas with 100% canola or soybean rather than the blended oil formulas were fed. The results show that formula fat composition influences the developing hematological system and that canola oil suppresses the normal developmental increase in platelet count in piglets by a mechanism apparently unrelated to the formula 16:0, 18:1, 18:2(n-6) or 18:3(n-3), or plasma phospholipid 20:4(n-6) or 20:5(n-3).

  1. Relation between obesity and the attainment of optimal blood pressure and lipid targets in high vascular risk outpatients.

    Science.gov (United States)

    Bhan, Vineet; Yan, Raymond T; Leiter, Lawrence A; Fitchett, David H; Langer, Anatoly; Lonn, Eva; Tan, Mary; Silagy, Stewart; Goodman, Shaun G; Yan, Andrew T

    2010-11-01

    Obesity is associated with hypertension, dyslipidemia, and diabetes, but it is also an independent cardiovascular risk factor. We sought to evaluate the differences in treatment patterns and attainment of guideline-recommended targets among high-risk vascular outpatients in relation to their body mass index (BMI). The prospective Vascular Protection and Guideline Orientated Approach to Lipid Lowering Registries recruited 7,357 high-risk vascular outpatients in Canada from 2001 to 2004. We stratified the patient population into 3 groups according to their BMI: normal weight (BMI 30 kg/m²). We evaluated the rates of attainment for contemporary guideline targets of blood pressure (high-density lipoprotein [HDL] ratio blood pressure, TC, LDL cholesterol, triglyceride levels and TC/HDL ratio, and lower HDL cholesterol. Obese patients were more likely to be treated with antihypertensive agents (p = 0.002), angiotensin-converting enzyme inhibitors (p = 0.024), angiotensin receptor blockers (p high-dose statin therapy (p = 0.001). On multivariable analyses, obese patients were less likely to attain the blood pressure (odds ratio 0.77, 95% confidence interval 0.66 to 0.90, p = 0.001) and TC/HDL ratio (odds ratio 0.48, 95% confidence interval 0.42 to 0.55, p high cardiovascular risk achieved both guideline-recommended blood pressure and lipid targets, and this significant treatment gap was more pronounced among obese patients. Our findings underscore the opportunity to optimize the treatment of these high-risk patients. Copyright © 2010 Elsevier Inc. All rights reserved.

  2. Dynamic changes of lipid acylhydroperoxide and Vitamin Eplasma levels in ischemic stroke patients

    Institute of Scientific and Technical Information of China (English)

    Huiming Mao; Ping Zhuang; Xianzhen Chen; Yongmin Yu; Bingguan Chen

    2008-01-01

    BACKGROUND: Studies have shown that malondialdehyde is the metabolic product of lipid peroxidation. However, detection of the intermediate metabolic product of lipid peroxidation, acylhydroperoxide (AHP), has rarely been reported. OBJECTIVE: To document concentrations of the intermediate metabolic product of lipid peroxidation, AHP, during different stages of ischemic cerebral infarction. DESIGN, TIME AND SETTING: Forty-eight patients with cerebral infarction from the East Hospital of Tongji University, and thirty-three students of Shanghai Geriatric University (healthy controls), in a case match-control study from April 2000 to January 2001. PARTICIPANTS: Based on different disease states, patients were separated into three groups: acute (n = 19), convalescent (n = 17), and chronic(n = 12). The healthy, control group consisted of 33 students, who were not treated with Vitamin E during the two weeks. METHODS: AHP concentration was detected by an ultraviolet spectrophotometric method, and plasma Vitamin E levels were detected by a visual spectrophotometric method. MAIN OUTCOME MEASURES: Plasma lipid AHP and Vitamin E levels of patients and healthy control groups. RESULTS: Plasma lipid AHP levels of patients in the acute group significantly increased compared with healthy control and convalescent groups (F = 4.40, P 0.05). No significant differences were detected in plasma lipid AHP and Vitamin E levels in the chronic group compared to the control and convalescent groups (P>0.05). CONCLUSIONS: Lipid pcroxidation, as evidenced by high plasma lipid AHP and low Vitamin E levels, occurs primarily during the acute stage of patients with cerebral infarction.

  3. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.

    Directory of Open Access Journals (Sweden)

    Margreet R Olthof

    2005-05-01

    Full Text Available BACKGROUND: Betaine (trimethylglycine lowers plasma homocysteine, a possible risk factor for cardiovascular disease. However, studies in renal patients and in obese individuals who are on a weight-loss diet suggest that betaine supplementation raises blood cholesterol; data in healthy individuals are lacking. Such an effect on cholesterol would counteract any favourable effect on homocysteine. We therefore investigated the effect of betaine, of its precursor choline in the form of phosphatidylcholine, and of the classical homocysteine-lowering vitamin folic acid on blood lipid concentrations in healthy humans. METHODS AND FINDINGS: We measured blood lipids in four placebo-controlled, randomised intervention studies that examined the effect of betaine (three studies, n = 151, folic acid (two studies, n = 75, and phosphatidylcholine (one study, n = 26 on plasma homocysteine concentrations. We combined blood lipid data from the individual studies and calculated a weighted mean change in blood lipid concentrations relative to placebo. Betaine supplementation (6 g/d for 6 wk increased blood LDL cholesterol concentrations by 0.36 mmol/l (95% confidence interval: 0.25-0.46, and triacylglycerol concentrations by 0.14 mmol/l (0.04-0.23 relative to placebo. The ratio of total to HDL cholesterol increased by 0.23 (0.14-0.32. Concentrations of HDL cholesterol were not affected. Doses of betaine lower than 6 g/d also raised LDL cholesterol, but these changes were not statistically significant. Further, the effect of betaine on LDL cholesterol was already evident after 2 wk of intervention. Phosphatidylcholine supplementation (providing approximately 2.6 g/d of choline for 2 wk increased triacylglycerol concentrations by 0.14 mmol/l (0.06-0.21, but did not affect cholesterol concentrations. Folic acid supplementation (0.8 mg/d had no effect on lipid concentrations. CONCLUSIONS: Betaine supplementation increased blood LDL cholesterol and triacylglycerol

  4. Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL Catabolism.

    Science.gov (United States)

    Briand, François; Mayoux, Eric; Brousseau, Emmanuel; Burr, Noémie; Urbain, Isabelle; Costard, Clément; Mark, Michael; Sulpice, Thierry

    2016-07-01

    In clinical trials, a small increase in LDL cholesterol has been reported with sodium-glucose cotransporter 2 (SGLT2) inhibitors. The mechanisms by which the SGLT2 inhibitor empagliflozin increases LDL cholesterol levels were investigated in hamsters with diet-induced dyslipidemia. Compared with vehicle, empagliflozin 30 mg/kg/day for 2 weeks significantly reduced fasting blood glucose by 18%, with significant increase in fasting plasma LDL cholesterol, free fatty acids, and total ketone bodies by 25, 49, and 116%, respectively. In fasting conditions, glycogen hepatic levels were further reduced by 84% with empagliflozin, while 3-hydroxy-3-methylglutaryl-CoA reductase activity and total cholesterol hepatic levels were 31 and 10% higher, respectively (both P catabolism of (3)H-cholesteryl oleate-labeled LDL injected intravenously by 20%, indicating that empagliflozin raises LDL levels through reduced catabolism. Unexpectedly, empagliflozin also reduced intestinal cholesterol absorption in vivo, which led to a significant increase in LDL- and macrophage-derived cholesterol fecal excretion (both P < 0.05 vs. vehicle). These data suggest that empagliflozin, by switching energy metabolism from carbohydrate to lipid utilization, moderately increases ketone production and LDL cholesterol levels. Interestingly, empagliflozin also reduces intestinal cholesterol absorption, which in turn promotes LDL- and macrophage-derived cholesterol fecal excretion.

  5. The relationship between levels of PCBs and pesticides in human hair and blood: preliminary result.

    Science.gov (United States)

    Altshul, Larisa; Covaci, Adrian; Hauser, Russ

    2004-08-01

    Human hair as a biologic measure of exposure to persistent organic pollutants (POPs) has some advantages over the more commonly used blood and adipose tissue samples. However, one of the primary limitations is the difficulty in distinguishing between exogenous and endogenous contamination. In addition, there are currently no standardized methods for hair sample collection, washing, and chemical analysis. There is also very limited information describing the correlation between levels of organic contaminants in hair and other body compartments. To explore levels of POPs in blood and hair, samples from 10 volunteers were collected and analyzed for select organochlorine pesticides and 57 individual polychlorinated biphenyl (PCB) congeners. We demonstrated that the method for analyzing organic contaminants in human hair was reliable and reproducible. Washing hair with shampoo decreased levels of PCBs, pesticides, and lipids by 25-33% on average and up to 62% for low-chlorinated congeners. The percentage of lipids and the levels of organochlorines in hair were higher than in serum. We found strong correlation (r = 0.8) between p,p -DDE (dichlorodiphenyldichloroethylene) levels in hair and blood and moderate correlations for the more persistent PCB congeners, but no correlations or weak correlations for other organochlorines. The present study provides preliminary evidence on the utility of hair analysis for POPs; however, further larger studies are recommended before hair analysis can be successfully applied in epidemiologic studies on POPs.

  6. Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta-analysis.

    Science.gov (United States)

    Cai, L; Wu, Y; Cheskin, L J; Wilson, R F; Wang, Y

    2014-12-01

    We aimed to assess the effects of childhood obesity prevention programmes on blood lipids in high-income countries. We searched MEDLINE®, Embase, PsychInfo, CINAHL®, clinicaltrials.gov, and the Cochrane Library up to 22 April 2013 for relevant randomized controlled trials, quasi-experimental studies and natural experiments published in English. Studies were included if they implemented diet and/or physical activity intervention(s) with ≥1 year follow-up (or ≥6 months for school-based intervention studies) in 2-18-year-olds, and were excluded if they targeted only overweight/obese children, or those with a pre-existing medical condition. Seventeen studies were finally included. For total cholesterol, the pooled intervention effect was -0.97 mg dL(-1) [95% confidence interval (CI): -3.26, 1.32; P = 0.408]; for low-density lipoprotein cholesterol (LDL-C), -6.06 mg dL(-1) (95% CI: -11.09, -1.02; P = 0.018); for high-density lipoprotein cholesterol (HDL-C), 1.87 mg dL(-1) (95% CI: 0.39, 3.34; P = 0.013); and for triglycerides, -1.95 mg dL(-1) (95% CI: -4.94, 1.04; P = 0.202). Most interventions (70%) showed similar significant or no effects on adiposity- and lipids outcomes: 15% interventions improved both adiposity- and lipids outcomes; 55% had no significant effects on either. Childhood obesity prevention programmes had a significant desirable effect on LDL-C and HDL-C. Two-thirds of interventions showed similar significant or no effects in adiposity- and lipids outcomes. Assessing lipids outcomes provide additional useful information on obesity prevention programme benefits.

  7. Video game playing is independently associated with blood pressure and lipids in overweight and obese adolescents.

    Directory of Open Access Journals (Sweden)

    Gary S Goldfield

    Full Text Available OBJECTIVE: To examine the association between duration and type of screen time (TV, video games, computer time and blood pressure (BP and lipids in overweight and obese adolescents. DESIGN: This is a cross-sectional study of 282 overweight or obese adolescents aged 14-18 years (86 males, 196 females assessed at baseline prior to beginning a lifestyle intervention study for weight control. Sedentary behaviours, defined as hours per day spent watching TV, playing video games, recreational computer use and total screen time were measured by self-report. We examined the associations between sedentary behaviours and BP and lipids using multiple linear regression. RESULTS: Seated video gaming was the only sedentary behaviour associated with elevated BP and lipids before and after adjustment for age, sex, pubertal stage, parental education, body mass index (BMI, caloric intake, percent intake in dietary fat, physical activity (PA duration, and PA intensity. Specifically, video gaming remained positively associated with systolic BP (adjusted r = 0.13, β = 1.1, p<0.05 and total cholesterol/HDL ratio (adjusted r = 0.12, β = 0.14, p<0.05. CONCLUSIONS: Playing video games was the only form of sedentary behaviour that was independently associated with increased BP and lipids. Our findings provide support for reducing time spent playing seated video games as a possible means to promote health and prevent the incidence of cardiovascular disease (CVD risk factors in this high risk group of overweight and obese adolescents. Future research is needed to first replicate these findings and subsequently aim to elucidate the mechanisms linking seated video gaming and elevated BP and lipids in this high risk population. TRIAL REGISTRATION: Clinicaltrials.gov NCT00195858.

  8. Blood levels of polychlorinated biphenlys and organochlorinated pesticides in women from Istanbul, Turkey.

    Science.gov (United States)

    Ulutaş, Onur Kenan; Çok, Ismet; Darendeliler, Feyza; Aydin, Banu; Çoban, Asuman; Henkelmann, Bernhard; Schramm, Karl-Werner

    2015-03-01

    The human body is not a chemically uncontaminated system. Every simple action that humans undertake, such as drinking water, eating, nursing, and even breathing air, puts the system under environmental xenobiotic exposure stress. Environmental chemicals have been shown to produce unwanted effects on health and remove the right to healthy living, starting from the first encounter in utero to geriatrics, throughout the lifespan. Organochlorine pesticides (OCPs) and polychlorinated biphenyl (PCB) levels, important members of the persistent organic pollutants (POPs), have been detected before in human breast milk and also in the adipose tissue of women from different regions of Turkey; however, there was no information about the blood levels of these chemicals. This study generated the first information that evaluates OCP and PCB contamination levels in the blood of the women living in Turkey. The current study measured the blood concentrations of OCPs and PCBs in 58 healthy women (age 20-41 years; mean age 28 years) who were living in Istanbul, Turkey, in the years 2010-2012. Samples were analyzed for 29 OCPs and 18 PCB congeners using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). PCB 153 was the predominant congener (643.2 pg/g lipid), followed by PCB 138 and PCB 180. 4,4'-DDE (24872.8 pg/g lipid) was the most common organochlorinated pesticide contaminant in studied blood samples. Results for analyzed chlorinated compounds were as follows: ∑PCB 2682 ± 3300 pg/g lipid; ∑DDT 25,938 ± 28,644 pg/g lipid; and ∑HCH 2930 ± 2222 pg/g lipid, respectively. The mean concentration of ∑WHOPCB-TEQ was 0.037 pg/g on a lipid basis. This information will be important base data during the assessment of the general health concerns of women, as well as for studies about how endocrine disruptors affect humans for forthcoming studies.

  9. Blood and urine 8-iso-PGF2α levels in babies of different gestational ages.

    Science.gov (United States)

    Li, Sitao; Hao, Hu; Zhou, Ping; Gao, Ping Ming; Xiao, Xin

    2014-01-01

    We measured cord blood and urine 8-iso-prostaglandin F2α (8-iso-PGF2α) levels in babies of different gestational ages to determine lipid peroxidation status. Babies at gestational ages of 28-43 weeks were divided into group A (28-32 weeks), group B (33-36 weeks), group C (37-41 weeks), and group D (42-43 weeks). 8-iso-PGF2α in umbilical cord blood (UCB) at birth and urine at 6 hours after birth was and tested by ELISA. UCB and urine 8-iso-PGF2α levels in group C were 130.09 ± 31.73 pg/ml and 27.14 ± 6.73 pg/ml, respectively. UCB 8-iso-PGF2α levels in group A and B were 188.42 ± 59.34 pg/ml and 189.37 ± 68.46 pg/ml, and urine 8-iso-PGF2α were 32.14 ± 7.32 pg/ml and 30.46 ± 8.83 pg/ml, respectively. Blood and urine 8-iso-PGF2α levels in group D (post-term) were 252.01 ± 46.42 pg/ml and 44.00 ± 8.50 pg/ml. For all babies, UCB and urine iso-PGF2α levels were significantly correlated (r = 0.65, P iso-PGF2α levels in normal full-term babies. Urine 8-iso-PGF2α levels may reflect the extent of lipid peroxidation in babies. In pre-term and post-term babies, there was evidence for increased lipid peroxidation.

  10. Blood lipid level, liver fat content and expression changes of fat-specific protein 27 in aged intrauterine growth restriction rats%宫内发育迟缓大鼠老年期血脂水平、肝脂肪含量及脂肪特异性蛋白27表达变化

    Institute of Scientific and Technical Information of China (English)

    雷小平; 邹礼乐; 董文斌; 康兰; 赵帅; 罗梅

    2016-01-01

    目的:观察宫内发育迟缓(IUGR)大鼠老年期血脂水平、肝脂肪含量及脂肪特异性蛋白27(Fsp27)表达变化。方法取IUGR和适于胎龄( AGA)大鼠各8只,分别设为IUGR组和AGA组。两组大鼠予标准配方饲料喂养至12月龄时处死,心腔穿刺采血,用酶法检测血浆LDL-C、TC、游离脂肪酸( FFA)、HDL-C及TG;取肝组织行HE染色,光镜下观察两组大鼠肝脏形态学改变;采用酶法测定肝脏TG和TC;采用逆转录聚合酶链反应法检测肝组织Fsp27 mRNA,采用Western blotting法检测肝组织Fsp27蛋白。结果 IUGR组、AGA组血浆TC分别为(0.57±0.14)、(0.32±0.15) mmol/gprot,LDL-C分别为(7.16±1.08)、(5.32±0.88) mmol/L,HDL-C 分别为(3.33±0.54)、(4.47±0.71)mmol/L,TG分别为(2.21±0.23)、(1.66±0.15)mmol/L,FFA分别为(1.46±0.25)、(1.17±0.21)mmol/L,两组比较,P均<0.01。 AGA组大鼠肝细胞形态、大小正常,胞质呈均匀红染,细胞内少见脂滴及空泡,而IUGR组大鼠肝细胞胞质内出现大量大小不等的脂滴及空泡。 IUGR组、AGA组大鼠肝组织TC分别为(1.41±0.37)、(1.03±0.30)mmol/gprot,TG分别为(2.38±0.39)、(1.81±0.54)mmol/L,两组比较,P均<0.05。 IUGR组、AGA组肝组织Fsp27 mRNA相对表达量分别为4.35±1.12、2.37±0.75,Fsp27蛋白相对表达量分别为1.19±0.23、0.69±0.16,两组比较,P均<0.01。结论与AGA大鼠相比,IUGR大鼠老年期血浆TC、LDL-C、TG、FFA水平高,血浆HDL-C水平低,肝组织脂肪含量高,这可能与肝组织Fsp27表达升高有关。%Objective To observe the blood lipid level, liver fat content and the expression changes of fat-specific protein 27 ( Fsp27) in the aged intrauterine growth restriction ( IUGR) rats.Methods A total of 8 newborn IUGR rats ( IUGR

  11. A study of C-reactive protein, lipid metabolism and peripheral blood to identify a link between periodontitis and cardiovascular disease.

    Science.gov (United States)

    Sharma, A; Astekar, M; Metgud, R; Soni, A; Verma, M; Patel, S

    2014-11-01

    Periodontitis is characterized by systemic inflammatory host responses that may contribute to a higher risk for cardiovascular disease. We hypothesized that periodontitis may be associated with altered C-reactive protein levels, serum levels of lipids and peripheral blood counts, and that these characteristics may serve as markers for a link between periodontitis and cardiovascular disease. Sixty subjects, 25-60 years old, were divided into three groups of 20 subjects each. Group 1, age and sex matched healthy controls; group 2, patients diagnosed with chronic periodontitis; group 3, patients diagnosed with acute periodontal lesions including periodontal abscess and pericoronal abscesses. Serum C-reactive protein levels, lipid levels and peripheral blood counts were obtained for all three groups. Significant increases in C-reactive protein and serum lipid levels, and altered peripheral blood counts were observed between the experimental groups; these factors were correlated with chronic periodontitis and cardiovascular disease. These simple, economical clinical measurements can be used to assess periodontal tissue damage and may be useful for predicting risk of cardiovascular disease in these subjects.

  12. fasting blood glucose and glycosylated haemoglobin levels

    African Journals Online (AJOL)

    Prince Acheampong

    (HbA1c) levels of diabetes mellitus patients as an index of glycaemic control. ... diabetics could be predisposed to microvascular complications, while a ... measurements of HbA1c of randomly selected patients with long-standing diabetes.

  13. High density lipoprotein level is negatively associated with the increase of oxidized low density lipoprotein lipids after a fatty meal.

    Science.gov (United States)

    Tiainen, Sanna; Ahotupa, Markku; Ylinen, Petteri; Vasankari, Tommi

    2014-12-01

    Recent reports show that a fatty meal can substantially increase the concentration of oxidized lipids in low density lipoprotein (LDL). Knowing the LDL-specific antioxidant effects of high density lipoprotein (HDL), we aimed to investigate whether HDL can modify the postprandial oxidative stress after a fatty meal. Subjects of the study (n = 71) consumed a test meal (a standard hamburger meal) rich in lipid peroxides, and blood samples were taken before, 120, 240, and 360 min after the meal. The study subjects were divided into four subgroups according to the pre-meal HDL cholesterol value (HDL subgroup 1, 0.66-0.91; subgroup 2, 0.93-1.13; subgroup 3, 1.16-1.35; subgroup 4, 1.40-2.65 mmol/L). The test meal induced a marked postprandial increase in the concentration of oxidized LDL lipids in all four subgroups. The pre-meal HDL level was associated with the extent of the postprandial rise in oxidized LDL lipids. From baseline to 6 h after the meal, the concentration of ox-LDL increased by 48, 31, 24, and 16% in the HDL subgroup 1, 2, 3, and 4, respectively, and the increase was higher in subgroup 1 compared to subgroup 3 (p = 0.028) and subgroup 4 (p = 0.0081), respectively. The pre-meal HDL correlated with both the amount and the rate of increase of oxidized LDL lipids. Results of the present study show that HDL is associated with the postprandial appearance of lipid peroxides in LDL. It is therefore likely that the sequestration and transport of atherogenic lipid peroxides is another significant mechanism contributing to cardioprotection by HDL.

  14. Inadequate physician knowledge of the effects of diet on blood lipids and lipoproteins.

    Directory of Open Access Journals (Sweden)

    Sciamanna Christopher

    2003-12-01

    Full Text Available Abstract Background To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins. Methods Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology. Results Response rate: 16% (n = 639. Half of the physicians did not know that canola oil and 26% did not know olive oil were good sources of monounsaturated fat. Ninety-three percent (84% of cardiologists vs. 96% of internists; p Conclusions If physicians are to implement dietary and cholesterol management guidelines, they will likely need to become more knowledgeable about nutrition.

  15. Proof of concept in cardiovascular risk: the paradoxical findings in blood pressure and lipid abnormalities

    Science.gov (United States)

    Fuchs, Flavio Danni; Fuchs, Sandra Costa; Moreira, Leila Beltrami; Gus, Miguel

    2012-01-01

    High blood pressure and lipoprotein abnormalities were identified by many cohort studies as the major risk factors for cardiovascular disease. Laboratory experiments apparently confirmed their role in the causation of atherosclerosis, but a proof of concept requires the corroboration by clinical trials in human beings. The size of benefit in clinical trials regarding the control of high blood pressure was within the estimations of risk provided by cohort studies. For a reduction of 10 mmHg in systolic blood pressure or 5 mmHg in diastolic blood pressure, the relative risk reduction of coronary heart disease was 22% (95% confidence interval 27%–17%) in a meta-analysis of clinical trials, close to the estimation of reduction of 25% (95% confidence interval 23%–27%) provided by a meta-analysis of cohort studies. The corresponding values for stroke were 41% (95% confidence interval 33%–48%) in clinical trials compared to a cohort risk prediction of 36% (95% confidence interval 34%–38%). This efficacy was shared by all blood pressure-lowering drugs. The same figure has not paradoxically happened with drugs that act over abnormalities of cholesterol and lipoproteins. Only statins, which have other beneficial actions as well, have consistently lowered the incidence of cardiovascular diseases, an efficacy that was not reproduced by older and newer quite potent lipid drugs. The adverse effects of these drugs may nullify their beneficial effects over lipoproteins and abnormalities of lipoproteins may only be surrogate markers of the underlying real risks. PMID:22870036

  16. Prevalence of Blood Pressure, Blood Glucose and Serum Lipids Abnormalities Among Ethiopian Immigrants: A Community-Based Cross-Sectional Study.

    Science.gov (United States)

    Ghobadzadeh, Maryam; Demerath, Ellen W; Tura, Yisehak

    2015-08-01

    The main objective of this study was to investigate the prevalence of hypertension, glucose and blood lipid abnormalities among a community of Ethiopian immigrants in Minnesota. This cross-sectional study used data from the parish nursing program 2007-2012. A total of 673 encounters were included in this study. Various dependent variables including systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose (BG), and serum lipids were examined. High blood pressure was defined as a mean SBP equal to or higher than 140 mm/Hg and/or DBP equal to or higher than 90 mmHg. Elevated fasting glucose defined as levels equal to or higher than 126 mg/dL. High level of total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and low high-density lipoprotein (HDL) cholesterol were defined as ≥240, ≥200, ≥160 and ≤40 mg/dL, respectively. General linear regression models were used to investigate the relationship of participants' age and gender, to the continuously distributed response variables, which included systolic and DBP, BG, TC, TG, LDL cholesterol and HDL cholesterol. This is a nonrandom sample of adult Ethiopian church members who were invited to participate in a parish nurse cardiovascular disease (CVD) risk factor screening program. Participants in this sample were 43 % male and 57 % female. The overall prevalence of hypertension was 30.1 % with a cut off mark of 140/90 mm/Hg. The prevalence of hypertension was 33 and 24 % among men than among women, respectively (p 240 mg/dL) were observed in 15 % of the women and 10 % of the men (p = 0.2). Higher SBP and DBP were significantly higher in male participants than their female counterparts (p  0.05). This opportunity sample suggests high prevalence of CVD risk factors in a community of Ethiopian-American adults, and a pressing need for more comprehensive and systematic assessment of chronic disease health needs in this growing community.

  17. Effect of Pyramidal Training on Plasma Lipid Profile and Fibrinogen, and Blood Viscosity of Untrained Young Men

    Directory of Open Access Journals (Sweden)

    Abbass Ghanbari-Niaki

    2013-09-01

    Full Text Available The present study examined the effects of progressive exercise (pyramidal short-term program on plasma fibrinogen, lipid profile and blood viscosity in untrained young men. Changes and imbalances in homeostasis lead to cause of heart attacks. There is conflicting information about the effect of exercise on these factors. 19 young healthy untrained men were randomly assigned to the exercise group (n = 10 and controls (n = 9 groups. Exercise training group with increasing severity of heart maximum 25 to 100 percent began to run the practice (pyramid in 42-minute sessions, 3 times a week, for 4 weeks. There was no significant difference between the parameters of body composition, control, and training groups. Levels of total cholesterol and low density lipoprotein density and viscosity of the blood significantly decreased in the training group compared with the control group (p value, respectively is 0.001, 0.001 and 0.035. The changes in the concentration of fibrinogen, high-density lipoprotein and triglycerides in both groups are not significant in both groups (p value, respectively is 0.645, 0.993 and 0.421. The present results show that it is possible that progressive training (pyramidal short-term program changed the levels of cardiovascular risk factors by reducing blood viscosity.

  18. Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.

    Directory of Open Access Journals (Sweden)

    Zhuofeng Lin

    Full Text Available BACKGROUND: Fibroblast growth factor 21 (FGF-21 is a metabolic regulator with multiple beneficial effects on glucose homeostasis and lipid metabolism in animal models. The relationship between plasma levels of FGF-21 and coronary heart disease (CHD in unknown. METHODOLOGY/PRINCIPAL FINDINGS: This study aimed to investigate the correlation of serum FGF-21 levels and lipid metabolism in the patients with coronary heart disease. We performed a logistic regression analysis of the relation between serum levels of FGF-21 and CHD patients with and without diabetes and hypertension. This study was conducted in the Departments of Endocrinology and Cardiovascular Diseases at two University Hospitals. Participants consisted of one hundred and thirty-five patients who have been diagnosed to have CHD and sixty-one control subjects. Serum FGF-21 level and levels of fasting blood glucose; triglyceride; apolipoprotein B100; HOMA-IR; insulin; total cholesterol; HDL-cholesterol; LDL-cholesterol; and C-reactive protein were measured. We found that median serum FGF-21 levels were significantly higher in CHD than that of control subjects (P<0.0001. Serum FGF-21 levels in CHD patients with diabetes, hypertension, or both were higher than that of patients without these comorbidities. Serum FGF-21 levels correlated positively with triglycerides, fasting blood glucose, apolipoprotein B100, insulin and HOMA-IR but negatively with HDL-C and apolipoprotein A1 after adjusting for BMI, diabetes and hypertension. Logistic regression analysis demonstrated that FGF-21 showed an independent association with triglyceride and apolipoprotein A1. CONCLUSIONS/SIGNIFICANCE: High levels of FGF-21 are associated with adverse lipid profiles in CHD patients. The paradoxical increase of serum FGF-21 in CHD patients may indicate a compensatory response or resistance to FGF-21.

  19. 2型糖尿病肾病患者不同时期凝血功能与血脂水平的变化及其临床意义%Changes of coagulation function and blood lipid level of patients with type 2 diabetes nephropathy during different periods and its clinical significance

    Institute of Scientific and Technical Information of China (English)

    陈日寿

    2015-01-01

    Objective To test coagulation function and blood lipid level of patients with type 2 diabetes nephropathy during different periods and explore its clinical significance.Methods 150 patients with type 2 diabetes nephropathy who were hospitalized and treated in Dongguan Hospital of Traditional Chinese Medicine were selected as research subject including 50 patient with normal proteinuria, 50 patients with microalbuminuria and 50 patient with clinical proteinuria. 50 people who were received physical examination in our hospital were selected as control group. Fasting blood-glucose, triglycerid, homocysteine, glycosylated hemoglobin, prothrombin time, activated partial thromboplastin time, fibrinogen and thrombin time of research subjects were tested, and all the index and data were compared and analyzed. Multivariate linear regression analysis was used and set MTP as dependent variable and set FBG, TG, HCY, HbA1C as independent variable to analyze correlation of these index. ResultsFBG, TG and FIB of patients with T2DN were significantly higher than those of control group, and those of patients with clinical proteinuria were significantly higher than those of patient with normal proteinuria and patients with microalbuminuria (P<0.05). Patients' TT was significantly prolonged (P<0.05). HCY of patients with clinical proteinuria was significantly higher than that of patients with normal proteinuria (P<0.05). The influence extent of independent variable including FBG, TG, HCY, HbA1C on dependent variable of MTP was HCY, FBG, TG and HbA1C in sequence. Conclusion Compared with common people, patients with T2DN have the symptoms of abnormal blood lipid levels and coagulation function disturbance. With the increase of MAU, the patients' HCY, HbA1C and FIB are gradually increased and TT is gradually prolonged. The greatest influence factors to MTP are HCY and FBG.%目的:检测2型糖尿病肾病患者不同时期的凝血功能和血脂水平,探讨其临床意义。方

  20. A retrospective cohort study of blood hemoglobin levels in blood donors and competitive rowers

    DEFF Research Database (Denmark)

    Johansson, P. I.; Ullum, H.; Jensen, Kurt;

    2009-01-01

    To investigate the distribution of blood hemoglobin levels in healthy blood donors and elite athletes, a retrospective cohort study from 2001 to 2005 of candidate blood donors and elite rowers in Denmark was performed. Eighty-five thousand eight hundred and forty-six blood donors were identified.......3% of the females demonstrated values above the recommended limit for athletic competition. Thus, the prevalence of a high hemoglobin value was greater in the rowers, of both gender, than in the candidate blood donors (P... people and especially in competition athletes....

  1. DIFFERENCES IN THE LEVELS OF LIPID STATUS IN PATIENTS WITH ISACHEMIC HEART DISEASE AND MALIGNANT DISEASE

    Directory of Open Access Journals (Sweden)

    Beretka Atila

    2009-01-01

    Full Text Available Arteriosclerosis is the basis of all cardiovascular diseases. Numerous risk factors lead to the rise of malignant and cardiovascular diseases. Those are: elevated artery blood pressure, raised plasma cholesterol and triglycerides, low level of HDL-cholesterol, smoking, diabetes mellitus, diet, lack of physical exercises, heredity, stress, gender.The aim of the study was to compare the lipid status of patients with cardiovascular disease or malignancy.The database of the biochemical laboratory and oncology counseling unit of the "Ostrog Clinic" was used. The method of random sample was used and patients (n=29 of both genders were selected, who were at the age of 40 to 47, with cardiovascular diseases, and had significant occlusive coronary disease, which required operation or surgical revascularization procedure. The patients were classified in two groups: G1 (n=14 with statin therapy and G2 (n=15 without statin therapy. Both groups were statistically compared with a group of female patients (n=30 with breast cancer, who were between 37 and 69 years of age. Control group comprised 25 healthy subjects. Standard statistical methods were used for processing the lipid status parameters, namely: the arithmetic mean, standard deviation SDn and SDn-1, correlation coefficient, post hock test and a single factor analysis of variance.The results obtained have pointed to the existence of a marked hyperlipoproteinemia type 4 in the group of cardiovascular patients who did not use statin (G2. In G2, higher levels of cholesterol, LDL-cholesterol and plasma triglycerides in comparison with the control and G1, while the value of HDL-cholesterol was within the range of referent values. The obvious suppressing effect of statin on cholesterol and LDL-cholesterol was observed in G1. Group G3 had, in comparison with the control and cardiovascular patients, significantly lower levels of cholesterol and triglycerides in plasma, as well as lower index of atherosclerosis

  2. Blood alcohol levels for American Indian mothers and newborns.

    Science.gov (United States)

    Kvigne, Valborg L; Randall, Brad; Simanton, Edward G; Brenneman, George; Welty, Thomas K

    2012-10-01

    Very little is known about the alcohol elimination rates of newborns who have had chronic alcohol exposure in utero. In these case reports, blood alcohol levels were taken immediately before delivery, at delivery, and postdelivery for 2 mothers who drank alcohol during their pregnancies and 3 single-birth newborns. Newborn A1 of Mother A had no physical characteristics of fetal alcohol syndrome (FAS). The initial blood alcohol level for this newborn was 38.4 mg/dL 129 minutes after birth, with a subsequent blood alcohol level of 5.5 mg/dL 304 minutes after delivery, resulting in an alcohol elimination rate of 11.3 mg/dL per hour. The blood alcohol level for Mother A was 87.4 mg/dL 66 minutes before delivery. Newborn A2 of mother A had FAS. Sixty minutes after delivery, the blood alcohol level for this newborn was 39.5 mg/dL, and the alcohol level of the mother was 42.1 mg/dL. Newborn B1 of mother B had FAS. At 67 minutes after birth, newborn B1 had a blood alcohol level of 246.5 mg/dL, which dropped to 178.7 mg/dL 302 minutes after birth, resulting in an alcohol elimination rate of 17.3 mg/dL per hour. This alcohol elimination rate is within the metabolism range (15-49 mg/dL per hour) of adults with alcoholism. The maternal blood alcohol level was 265.9 mg/dL 27 minutes before delivery. Blood alcohol levels drawn on both the mother and newborn at delivery and 2 or 3 hourly follow-up levels can provide evidence that fetal alcohol dehydrogenase activity is induced by chronic maternal alcohol use.

  3. 社区健康教育对控制冠心病患者血脂水平的作用分析%Analysis of the impact of community health education on the blood lipid level control in patients with coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    曾会云; 胡贤主

    2015-01-01

    Objective To analyze the role of community health education on controlling blood lipid levels in patients with coronary artery disease. Methods From April 2010 to December 2014, 200 patients with coronary heart disease in our hospital were selected and randomly divided into observation group and control group with 100 cases in each group. The control group received routine nursing care, while the observation group received community health education on the basis of routine nursing care. The differences of TC,TG,LDL-C and score of SF-36 and CSMS before and half a year after intervention were monitored and compared. Results After the intervention, the TC, TG, LDL-C levels of patients in observation group were significantly lower than those before intervention (all P < 0. 05), and also significantly lower than those in control group (all P < 0. 05). The HDL-C levels of patients in observation group were significantly higher than those before intervention (all P < 0. 05), and significantly higher than those in control group (all P <0. 05). After the intervention, the score of physiological function, physiological intelligence, bodily pain, general health, energy, social function, emotional function, mental health of SF-36 scale of patients in the observation group were significantly higher than those before intervention (all P < 0. 05), and significantly higher than in control group ( all P < 0. 05 ) . After the intervention, the CSMS scale including the capabilities of bad hobby management, symptom management, emotional management, emergency management, cognitive knowledge of disease management and life management, treatment compliance management in the observation group were significantly higher than those before intervention (all P < 0. 05), and significantly higher than those in control group ( all P < 0. 05) . Conclusions Community health education can help control blood lipid levels, improve quality of life, and enhance self-management skills in patients with

  4. Effects of Inulin on Lipid Profile, Inflammation and Blood Pressure in Women with Type 2 Diabetes: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Bahram Pourghassem Gargari

    2013-12-01

    Full Text Available Background & Objectives: Diabetes mellitus is a metabolic disease characterized by hyperglycemia together with biochemical alterations of lipid profile, insulin resistance and inflammation . Considering the high prevalence of hypertension, dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of inulin on lipid profile, inflammation and blood pressure in women with type 2 diabetes.   Methods: In this controlled, randomized clinical trial, 49 women with type 2 diabetes (fiber intake 0.04 . Changes in diastolic blood pressures, LDL-c and HDL-c were not significant in inulin group compared with the maltodextrin group. A significant decrease in systolic, diastolic blood pressures, total cholesterol, triglyceride, LDL-c, hs-CRP and significant increase in HDL-c were observed in inulin group compared to baseline.   Conclusions: Inulin supplementation may improve lipid profile, hs-CRP and blood pressure in women with type 2 diabetes.

  5. n -- 3 fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids.

    Science.gov (United States)

    Barden, Anne E; Dunstan, Janet A; Beilin, Lawrence J; Prescott, Susan L; Mori, Trevor A

    2006-10-01

    n--3 Fatty acids derived from fish oil reduce plasma triacylglycerols (triglycerides) and increase HDL-C (high-density lipoprotein cholesterol); however, the effect of n--3 fatty acid supplementation during pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune function in infants born to women with allergic disease. Eighty-three pregnant women who had allergic disease, but were otherwise healthy, completed the study. They were randomly allocated to receive fish oil or olive oil capsules, taken as 4 g/day, from 20 weeks of pregnancy until delivery. Compared with olive oil, fish oil supplementation did not alter triacylglycerols, total cholesterol, LDL-C (low-density lipoprotein cholesterol) or HDL-C during or after pregnancy. There was also no effect of fish oil on cord blood triacylglycerols, total cholesterol, LDL-C or HDL-C. Fish oil supplementation during pregnancy did not alter maternal blood pressure during or after pregnancy. The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy.

  6. The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

    Science.gov (United States)

    Amraie, Esmaiel; Farsani, Masome Khosravi; Sadeghi, Leila; Khan, Tayaba Naim; Adavi, Zohrab

    2015-01-01

    Diabetes is a common metabolic disorder that is specified by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The use of nonpharmacological treatments (herbal agents) is a new approach in the management of diabetes. The aim of this study was to investigate the effect of aqueous extract of alfalfa on blood glucose and serum lipids in alloxan-induced diabetic rats. In this study, 32 female rats (210–250 g) were used which were divided randomly into 4 groups including intact control group, diabetic control group, and 2 diabetic groups which received 250 and 500 mg/kg doses of aqueous extract of alfalfa, respectively. In the diabetic groups, alloxan-monohydrate was injected peritoneally to create diabetic condition. The two last groups orally received aqueous extract of alfalfa for 21 days. At the end of experiment, sugar, cholesterol, triglycerides, high-density and low-density lipoprotein, and aspartate aminotransferase (ALT) and alanine aminotransferase (AST) levels were measured in the samples. Consumption of aqueous alfalfa extract significantly reduced glucose, cholesterol, triglycerides, and low-density lipoprotein (LDL) levels in the diabetic rats but enhanced high-density lipoprotein (HDL) levels. ALT and AST liver enzyme levels were also reduced in blood. Histological examination showed that the aqueous alfalfa extract caused reconstruction of damaged liver and enhanced Langerhans islets’ diameter in pancreas. Therefore, all signs of diabetes were improved by oral administration of alfalfa in defined dose. PMID:26525173

  7. Dietary Fatty Acids and Changes in Blood Lipids during Adolescence: The Role of Substituting Nutrient Intakes.

    Science.gov (United States)

    Harris, Carla; Buyken, Anette; Koletzko, Sibylle; von Berg, Andrea; Berdel, Dietrich; Schikowski, Tamara; Koletzko, Berthold; Heinrich, Joachim; Standl, Marie

    2017-02-11

    The relevance of dietary fatty acids (FA) for blood lipids should be assessed in the context of substituting nutrients. Such evidence is lacking for adolescents. This study describes prospective associations of dietary FA with changes in serum lipids during adolescence, and considers the theoretical isocaloric replacements of saturated FA (SFA) with other FA or carbohydrates (CHO). Children from the GINIplus and LISAplus birth cohorts, with data on FA intakes (at age 10 years) and serum lipids (at age 10 and 15 years), were included (n = 1398). Associations of SFA, monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA) and n-6 PUFA, with changes in low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TAG), and total cholesterol to HDL ratio (TOTAL:HDL), were assessed by linear regression. Substitution models assessed isocaloric replacements of SFA with MUFA, n-3 PUFA, n-6 PUFA or CHO. Higher SFA intakes were associated with decreasing TAG. No associations were observed for fatty acid intakes with LDL, HDL or TOTAL:HDL. In females, replacing SFA with CHO was associated with increasing LDL, TAG and TOTAL:HDL. Our findings confirm observations in adults, although sex-specific determinants seem relevant in our adolescent population. Overlooking the nutrient context when limiting SFA intakes might have detrimental consequences appreciable as early as adolescence.

  8. Cordyceps sinensis biomass produced by submerged fermentation in high-fat diet feed rats normalizes the blood lipid and the low testosterone induced by diet

    Science.gov (United States)

    Freire dos Santos, Leandro; Rubel, Rosália; Bonatto, Sandro José Ribeiro; Zanatta, Ana Lucia; Aikawa, Júlia; Yamaguchi, Adriana Aya; Torres, Maria Fernanda; Soccol, Vanete Thomaz; Habu, Sascha; Prado, Karin Braun; Soccol, Carlos Ricardo

    2012-01-01

    This study investigated the effect of Cordyceps sinensis biomass supplementation obtained from submerged fermentation on blood lipid and low testosterone induced by high-fat diet (HFD). The experiments were carried out using a long-term intake of HFD and HFD plus Simvastatin or C. sinensis (4 months). Our results show that plasma cholesterol, triglycerides and LDL were decreased by Cordyceps sinensis biomass supplementation (CSBS). A long-term intake of HFD caused a significant liver damage which has been reverted by CSBS. CSBS normalized decreasing testosterone levels observed in high-fat diet feed rats. All these findings lead us to suggest that C. sinensis was able to decrease blood lipid concentration, increase hepatoprotective activity and normalize testosterone levels. PMID:27847459

  9. [Analysis of serum lipids levels and the establishment of reference intervals for serum lipids in middle and late pregnancy].

    Science.gov (United States)

    Ying, Chunmei; Yue, Chaoyan; Zhang, Chunyi; Li, Xiaotian

    2015-12-01

    To explore the serum lipids levels in healthy pregnant women, and to establish the reference intervals of serum lipids in middle and late pregnancy. Triglyceride (TG), total cholesterol (TCH), high density lipoprotein (HDL), low density lipoprotein (LDL), apo-lipoprotein-A(APO-A) and apo-lipoprotein-B (APO-B) were measured in 3 200 pregnant women and 3 200 healthy women of childbearing age(the control group) from January 2014 to Febuary 2015 in Obstetrics and Gynecology Hospital of Fudan University. In the healthy pregnant women, serum lipids were measured at 14-20, 24-28 and 37-40 gestational weeks, respectively. All the parameters were detected by Hitachi 7180 automatic biochemical analyzer. The test results were calculated and determined by the C28-A3 standard of the National Clinical and Laboratory Standards Institute. And the normal reference intervals of serum lipids in middle and late pregnancy were defined as 2.5%-97.5%. (1) The levels of TG, TCH, HDL, LDL, APO-A and APO-B in the control group were 0.8, 4.2, 1.0, 2.7 mmol/L and 1.1, 0.8 g/L, respectively. The levels of TG, TCH, HDL, LDL, APO-A and APO-B in middle and late pregnancy were significantly higher than those in the control group (Plipids levels at 14-20, 24-28 and 37-40 gestational weeks in healthy pregnant women were compared with the control group as following. The TG levels were 1.9, 3.8 and 4.4 folds of the control group; the TCH levels were 1.1, 1.5 and 1.5 folds of the control group; the HDL levels were 1.2, 1.6 and 1.5 folds of the control group; the LDL levels were 1.1, 1.4 and 1.4 folds of the control group; the APO-A levels were 1.3, 1.4 and 1.5 folds of the control group; and the APO-B levels were 1.1, 1.5 and 1.5 fold of the control group respectively. The TG level was the most increased, and it increased gradually with gestational age (Plipids at 14-20, 24-28 and 37-40 gestational weeks in healthy pregnant women were as following. The TG levels were 0.7-3.9, 1.7-6.3 and 1.6-8.1 mmol

  10. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus.

    Science.gov (United States)

    Racek, Jaroslav; Trefil, Ladislav; Rajdl, Daniel; Mudrová, Vlasta; Hunter, Douglas; Senft, VáClav

    2006-03-01

    The aim of this study was to determine the effect of chromium (Cr)- enriched yeast on blood glucose and insulin variables, blood lipids, and blood markers of oxidative stress in persons with type 2 diabetes mellitus (median duration: 3.0 yr). Thirty-six subjects (9 men, 27 women; mean age: 61.3 yr; mean body mass index: 34.33 kg/m2) were supplemented with 400 microg Cr/d as Cr-enriched yeast (n = 19) or placebo (n = 17) for 12 wk in a randomized, double-blind study. The most interesting results were obtained by comparison of the change in the placebo group to the change in the Cr group. The Cr group showed a significantly greater increase in serum Cr compared to the placebo group (p < 0.05). Supplementation with Cr-enriched yeast was associated with a significant decrease in fasting serum glucose compared to placebo (p < 0.01). Blood markers of oxidative stress glutathione peroxidase activity and levels of reduced glutathione were essentially unchanged in the Cr group after 12 wk, but decreased significantly in the placebo group (p < 0.05, p < 0.01, respectively). Serum HbA1c and glycated protein (fructosamine) were essentially unchanged in the Cr group, whereas HbA1c tended to increase in the placebo group (from 6.94% to 7.11%). Fasting serum insulin decreased in both groups, with a greater tendency in the Cr group (-16.5% vs -9.5%). These data suggest that supplementation of well-controlled type 2 diabetics with Cr-enriched yeast is safe and can result in improvements in blood glucose variables and oxidative stress.

  11. Comparison between swallowing and chewing of garlic on levels of serum lipids, cyclosporine, creatinine and lipid peroxidation in Renal Transplant Recipients

    Directory of Open Access Journals (Sweden)

    Ghorbanihaghjo Amir

    2005-05-01

    Full Text Available Abstract Abstract Hyperlipidemia and increased degree of oxidative stress are among the important risk factors for Atherosclerosis in renal transplant recipients (RTR. The Medical treatment of hyperlipidemia in RTR because of drugs side effects has been problematic, therefore alternative methods such as using of Garlic as an effective material in cholesterol lowering and inhibition of LDL Oxidation has been noted. For evaluation of garlic effect on RTR, 50 renal transplant patients with stable renal function were selected and divided into 2 groups. They took one clove of garlic (1 gr by chewing or swallowing for two months, after one month wash-out period, they took garlic by the other route. Results indicated that although lipid profile, BUN, Cr, serum levels of cyclosporine and diastolic blood pressure did not change, Systolic blood pressure decreased from138.2 to 132.8 mmHg (p=0.001 and Malondialdehyde (MDA decreased from 2.4 to1.7 nmol/ml (p=0.009 by swallowing route, Cholesterol decreased from 205.1 to 195.3 mg/dl (p=0.03, triglyceride decreased from 195.7 to 174.8 mg/dl (p=0.008, MDA decreased from 2.5 to 1.6 nmol/ml (p=0.001, systolic blood pressure decreased from 137.5 to 129.8 mmHg (p=0.001, diastolic blood pressure decreased from 84.6 to 77.6 mmHg (p=0.001 and Cr decreased from 1.51 to 1.44 mg/dl (p=0.03 by chewing route too. However HDL, LDL and cyclosporine serum levels had no significant differences by both of swallowing and chewing routes. We conclude that undamaged garlic (swallowed had no lowering effect on lipid level of serum. But Crushed garlic (chewed reduces cholesterol, triglyceride, MDA and blood pressure. Additionally creatinine reduced without notable decrease in cyclosporine serum levels may be due to cyclosporine nephrotoxicity ameliorating effect of garlic.

  12. Organization of Lipids in the Tear Film: A Molecular-Level View

    Science.gov (United States)

    Wizert, Alicja; Iskander, D. Robert; Cwiklik, Lukasz

    2014-01-01

    Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the current knowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick non-polar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their non-polar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional aggregates of polar lipids in both non-polar and water subphases is observed. We suggest that these three-dimensional structures are abundant under dynamic conditions caused by the action of eye lids and that they act as reservoirs of polar lipids, thus increasing stability of the tear film. PMID:24651175

  13. blood lead level and haematology of feral and cultured african ...

    African Journals Online (AJOL)

    UNIVERSITY OF IBADAN

    of fish health, this present work assessed the blood lead level (BLL) and ... humans who consume such contaminated fish. ... on the physiological response of fish due ... stress conditions like exposure to ..... respiration, gill ventilation and.

  14. Effect of Early Enteral Nutrition with Probiotic on Blood Lipid and Hs-CRP Levels in Critically Ill Patients%添加益生菌的早期肠内营养对危重患者血脂和超敏C反应蛋白水平的影响

    Institute of Scientific and Technical Information of China (English)

    王新岩; 于朝霞; 于湘友

    2015-01-01

    Objective To determine the effect of early enteral nutrition with probiotic on blood lipid and high -sensitivity C - reactive protein( hs - CRP) in critically ill patients in intensive care unit. Methods From August 2012 to October 2013,in the First Affiliated Hospital of Xinjiang Medical University,45 critically ill patients were divided randomly into groups study(n = 23;3 patients were excluded due to leaving hospital without cure or surviving 0. 05),no in levels of TG,TC,LDL - C,HDL - C,hs - CRP before treatment (P > 0. 05),and no in TC,LDL - C after treatment(P > 0. 05),the levels of TG,hs - CRP were lower,HDL - C higher in study group than in control group(P < 0. 05). Conclusion Enteral nutrition with probiotics is conducive to improving blood lipid level in critically ill patients and can reduce inflammation,thereby to decrease the risks of cardiovascular diseases.%目的:探讨添加益生菌的早期肠内营养对危重患者血脂水平和超敏 C 反应蛋白(hs - CRP)水平的影响。方法选取2012年8月—2013年10月新疆医科大学第一附属医院 ICU 收治的危重患者45例,采用随机数字表法将其分为试验组23例和对照组22例。研究期间试验组2例患者自动出院,1例患者生存时间<7 d 予以剔除,试验组最终实际纳入20例。两组患者均于入 ICU 治疗后24~48 h,且血流动力学稳定后,经鼻胃营养管由营养泵持续泵入肠内营养液瑞素进行营养支持;试验组在此基础上使用益生菌制剂。分别于治疗前、治疗第7天检测两组患者三酰甘油(TG)、总胆固醇、高密度脂蛋白胆固醇(HDL - C)、低密度脂蛋白胆固醇(LDL - C)和 hs - CRP 水平。结果两组患者性别、年龄、体质指数、急性生理与慢性健康状况评分Ⅱ(APACHE Ⅱ)、疾病构成比较,差异均无统计学意义(P >0.05)。治疗前,两组患者 TG、总胆固醇、LDL - C、HDL - C 和 hs - CRP 水平比较,差

  15. 高龄老年人脉压差、血脂、血糖关系分析%Analysis of the Correlation between Pulse Pressure,Blood Lipid,Blood Sugar in the Elderly People

    Institute of Scientific and Technical Information of China (English)

    丁翊; 刘芳

    2013-01-01

    Objective:Removed the age factor, to probe into the correlation between blood pressure,blood lipid,blood sugar and arteriosclerosis in the elderly people. Methods:Analyzed the correlation between Pulse Pressure,Mean Arterial blood pressure and Diabetes mellitus,Hypertension in 279 examination of the elderly. analyzed the changes of blood glucose,blood lipid at the different levels of Pulse Pressure. In order to know the correlation between Pulse Pressure,Mean Arterial blood pressure and blood glucose,blood lipid, blood pressure. Results:There was a correlation between arteriosclerosis and arterial compliance in the elderly people and hyperglycemia,the disorder of lipid metabolism and high systolic blood pressure. Conclusions:Strengthened the blood glucose management and the treatment of dyslipidemia in patients with diabetes mellitus, strengthened the control of blood pressure in patients with essential hypertension, these measures had a positive effect on prevention and treatment of senile arteriosclerosis.%目的:探讨老年动脉硬化除去年龄因素以外与血压、血糖、血脂的关系。方法:体检的老年人279例,分析脉压、平均动脉压与糖尿病、高血压病的关系及不同脉压水平下血糖、血脂的变化,进一步了解脉压、平均动脉压与血糖、血脂、血压之间的关系。结果:高龄老年人动脉硬化、血管顺应性减低与血糖增高、血脂代谢紊乱、收缩压增高有关。结论:加强糖尿病患者的血糖管理及血脂紊乱的治疗、加强高血压病患者血压控制对老年动脉硬化的防治有积极作用。

  16. Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine.

    Science.gov (United States)

    Bradshaw, Heather B; Leishman, Emma

    2016-05-01

    Rates of osteoporosis are significantly lower in regions of the world where olive oil consumption is a dietary cornerstone. Olive oil may represent a source of oleoyl serine (OS), which showed efficacy in animal models of osteoporosis. Here, we tested the hypothesis that OS as well as structurally analogous N-acyl amide and 2-acyl glycerol lipids are present in the following cooking oils: olive, walnut, canola, high heat canola, peanut, safflower, sesame, toasted sesame, grape seed, and smart balance omega. Methanolic lipid extracts from each of the cooking oils were partially purified on C-18 solid-phase extraction columns. Extracts were analyzed with high-performance liquid chromatography-tandem mass spectrometry, and 33 lipids were measured in each sample, including OS and bioactive analogs. Of the oils screened here, walnut oil had the highest number of lipids detected (22/33). Olive oil had the second highest number of lipids detected (20/33), whereas grape-seed and high-heat canola oil were tied for lowest number of detected lipids (6/33). OS was detected in 8 of the 10 oils tested and the levels were highest in olive oil, suggesting that there is something about the olive plant that enriches this lipid. Cooking oils contain varying levels of bioactive lipids from the N-acyl amide and 2-acyl glycerol families. Olive oil is a dietary source of OS, which may contribute to lowered prevalence of osteoporosis in countries with high consumption of this oil.

  17. Effect of Two Isocaloric Diets, Low Fat- High Calcium and Low Fat- High Fiber on Weight Reduction, Lipid Profile, and Blood Pressure

    Directory of Open Access Journals (Sweden)

    MH Eftekhari

    2009-12-01

    Full Text Available Background: Coronary Heart Disease is commonly associated with obesity, raised serum lipid levels and changes in blood pressure. The present study was designed to assess the effect of low fat- high calcium, and low fat- high fiber diets on weight reduction, lipid profile and blood pressure.Methods: The study sample consisted of 136 referred patients adult, obese men aged 53-64 years. Samples randomly were subdivided in two groups. Group 1 was advised 1600 calories, 20% fat, 1600 mg calcium rich diet and group 2 followed similar diet as for group 1 except a total daily intake of 55g fiber and 900 mg calcium per day for 12 weeks. Blood samples were collected and assayed for total cholesterol, LDL-cholesterol, HDLcholesterol and TG. Anthropometric assessments included measurement of weight, height, and waist circumferences followed by calculating Body mass index. Systolic and diastolic blood pressures were measured by using sphygmomanometer. Statistical analysis was performed with parametric and non-parametric methods as appropriate.Results: Data analysis revealed a significant decrease in total cholesterol, LDL-cholesterol, and TG in two groups, without any significant changes in HDL-cholesterol. Weight and blood pressure decreased in two groups, but the rate of reduction in blood pressure, weight and waist circumference were more significant in group 1 compared to group 2.Conclusion: An increase in dietary calcium intake, together with a Low calorie, low-fat diet can increase lipolysis in fat tissues, make greater weigh loss, ameliorate blood pressure, improve lipid levels, and reduce the risk of coronary vascular diseases.

  18. Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats

    Directory of Open Access Journals (Sweden)

    Chia-Chen Hsu

    2017-06-01

    Full Text Available Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear. Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin. The changes in the released β-endorphin-like immunoreactivity (BER were determined using ELISA. Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced in the absence of calcium ions. Activation of the imidazoline I-2 receptor (I-2R has been introduced to induce opioid secretion. Interestingly, we observed that diosmin activates CHO cells expressing I-R. Additionally, diosmin-increased BER was inhibited by the blockade of I-2R in isolated adrenal glands. Additionally, an antagonist of I-2R blocked diosmin-induced effects, including the reduction in hyperglycemia and the increase in plasma BER in streptozotocin-induced diabetic rats (STZ-diabetic rats. Repeated treatment of STZ-diabetic rats with diosmin for one week induced changes in hepatic glycogen, lipid levels, and the expression of phosphoenolpyruvate carboxykinase (PEPCK. Furthermore, an antagonist of I-2R blocked the diosmin-induced changes. Additionally, plasma lipids modified by diosmin were also reversed by the blockade of I-2R in STZ-diabetic rats. Taken together, we suggest that diosmin may activate I-2R to enhance the secretion of β-endorphin from adrenal glands and to influence metabolic homeostasis, resulting in alleviation of blood glucose and lipids in STZ-diabetic rats.

  19. The effect of dietary alpha-bromopalmitate on blood lipids in the rat.

    Science.gov (United States)

    Hagve, T A; Narce, M; Grønn, M; Christensen, E; Ulmann, L; Poisson, J P; Christophersen, B

    1989-07-17

    When alpha-bromopalmitate was fed to rats for 9-30 days, the level of serum triacylglycerol increased up to 2-fold over the concentration of controls. alpha-Bromopalmitate treatment had no effect on concentration of complex lipids in liver, while the triacylglycerol level in heart was significantly enhanced. From metabolic studies using isolated hepatocytes and liver microsomes, it is suggested that the increased serum triacylglycerol level after alpha-bromopalmitate feeding is mainly due to reduced fatty acid oxidation in both liver and peripheral tissues, and to a lesser extent, to inhibited fatty acid uptake and esterification.

  20. Serum Calcium Level is Associated with Lipids in Young Nigerian ...

    African Journals Online (AJOL)

    blood pressure in young Nigerian women who use OCP. Subjects and Methods: Fasting ... increasing core body temperature[21] or reduced body fat accumulation. ..... observed decrease in HDL-c may be due to up-regulation of hepatic lipase ...

  1. Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood of Premature Infants

    DEFF Research Database (Denmark)

    Dahl, Marianne; Holmskov, Uffe; Husby, Steffen

    2006-01-01

    of SP-D in capillary blood day 1 was 1,466 ng/mL (range 410-5,051 ng/mL), with lowest values in infants born with ROM and delivered vaginally. High SP-D levels in umbilical cord blood and capillary blood on day 1 were found to be more likely in infants in need for respiratory support or surfactant...

  2. The history of childhood trauma is associated with lipid disturbances and blood pressure in adult first-episode schizophrenia patients.

    Science.gov (United States)

    Misiak, Błażej; Kiejna, Andrzej; Frydecka, Dorota

    2015-01-01

    It has repeatedly been found that early-life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients. The history of childhood trauma was assessed using the Early Trauma Inventory Self Report - Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma: FES(+) and FES(-) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters and resting systolic and diastolic blood pressure (SBP and DBP) were measured. The history of childhood trauma was associated with higher low-density lipoprotein (LDL) levels, SBP and DBP after covarying for age, gender, body mass index, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, high-density lipoprotein, SBP, DBP and the number of metabolic syndrome criteria. Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients. Copyright © 2015. Published by Elsevier Inc.

  3. Brachial blood flow under relative levels of blood flow restriction is decreased in a nonlinear fashion.

    Science.gov (United States)

    Mouser, J Grant; Ade, Carl J; Black, Christopher D; Bemben, Debra A; Bemben, Michael G

    2017-04-12

    Blood flow restriction (BFR), the application of external pressure to occlude venous return and restrict arterial inflow, has been shown to increase muscular size and strength when combined with low-load resistance exercise. BFR in the research setting uses a wide range of pressures, applying a pressure based upon an individual's systolic pressure or a percentage of occlusion pressure; not a directly determined reduction in blood flow. The relationship between relative pressure and blood flow has not been established. To measure blood flow in the arm under relative levels of BFR. Forty-five people (18-40 years old) participated. Arterial occlusion pressure in the right arm was measured using a 5-cm pneumatic cuff. Blood flow in the brachial artery was measured at rest and at pressures between 10% and 90% of occlusion using ultrasound. Blood flow decreased in a nonlinear, stepped fashion. Blood flow decreased at 10% of occlusion and remained constant until decreasing again at 40%, where it remained until 90% of occlusion. The decrease in brachial blood flow is not proportional to the applied relative pressure. The prescription of blood flow restriction should take into account the stimulus provided at each relative level of blood flow. © 2017 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  4. Blood lead levels following consumption of game meat in Italy.

    Science.gov (United States)

    Fustinoni, Silvia; Sucato, Sabrina; Consonni, Dario; Mannucci, Pier Mannuccio; Moretto, Angelo

    2017-05-01

    The aim of this study was to measure lead (Pb) levels in blood (Pb-blood) in consumers of game meat, taking into account other possible sources of lead exposure. A spot blood sample was obtained from 95 subjects, and a questionnaire was used to collect general information and data on game meat consumption, hunting, wine drinking and other possible sources of lead exposure. Pb-blood was measured by inductively coupled plasma-mass spectrometry. Pb-blood was not influenced by age, sex, residence in an urban or rural area, consumption of game meat, tobacco smoking or hobbies associated with potential exposure to lead, and median Pb-blood was 1.7 (5th-95th percentile 1.0-5.3)µg/dL and 3.4 (0.9-6.1)µg/dL for game meat non-eaters and eater, respectively. A multiple linear regression analysis (containing the covariates sex, age, hunting, wine drinking, game meat consumption, tobacco smoking, shooting range, and occupational exposure) found an association with hunting (Pb-blood almost double in hunters) and wine drinking (40% higher in drinkers) but not with consumption of game meat or other parameters. Whether the higher Pb-blood level was due to inhalation of lead fumes while shooting with lead ammunition, to handling lead ammunition or both could not be ascertained. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients

    Directory of Open Access Journals (Sweden)

    Nilgun Solak Tekin

    2007-01-01

    Full Text Available Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. Objective. Our purpose was to evaluate the plasma lipids and oxidized low-density lipoprotein accumulation in psoriatic skin lesion in order to ascertain the possible participation of oxidative stress and oxidative modification of lipids in pathogenesis of psoriasis. Methods. The study group included 84 patients with psoriasis, and 40 sex- and age-matched healthy volunteers. Blood lipid profile was determined. Psoriatic and nonlesional skin samples of psoriatic patients were evaluated for the presence of oxidized low-density lipoprotein by using an immune-fluorescent staining method. Results. The mean levels of lipids (total cholesterol, triglyceride, and LDL cholesterol in patients with psoriasis were found to be significantly higher than those of healthy subjects. Psoriatic skins were shown positive oxidized low-density lipoprotein staining. There was no staining in nonlesional skin samples of the same individuals. Conclusion. Lipid peroxidation mediated by free radicals is believed to be one of the important causes of cell membrane destruction and cell damage. This study shows for the first time the accumulation of oxidized low-density lipoprotein in psoriatic skin lesion. We believe that accumulation of ox-LDL in psoriatic skin may have an important role in the immune-inflammatory events that result in progressive skin damage.

  6. Effects of Ethanol Leaf Extract of Ficus Glumosa on Fasting blood Glucose and Serum Lipid Profile in Diabetic Rats.

    Science.gov (United States)

    Umar, Z U; Moh'd, A; Tanko, Y

    2013-06-30

    Ficus glumosa, commonly known as the fig tree or "African rock fig" is a plant with immense medicinal value used for the management of diabetes for over 2000 years. The aim of the present study is to determine the hypoglycemic and anti-lipidemic properties of the ethanolic leaves extract of Ficus glumosa in alloxan-induced diabetic Wistar rats. Thirty (30) adult male Wister rats weighing (120 - 220) grams of about 18 to 22 weeks of age were used in the study. The animals were assigned into six groups (1-6) of five rats (n=5) each. Group VI served as the positive control group receiving 0.9% normal saline (5ml/kg) alone via intra-peritoneal route (i.p.), Groups I (negative control), II, III, IV and V were treated with alloxan and after the induction of hyperglycaemia, received in addition via i.p. for 7 days: 0.9% normal saline (5ml/kg) alone, 100mg/kg, 200mg/kg and 400mg/kg of ethanolic leaves extract of Ficus glumosa respectively while Group V received 6lU/kg of short-acting insulin. The determinations of blood glucose levels were carried out at intervals of one day for 7 days. Serum lipid profile, were done on the 7th day.Premininary phytochemical screening revealed the presence of flavonoids,saponin,tannins,cardiac glycosides,triterpenes,ceramides and reducing sugars.The LD50 of the extract of Ficus glumosa was found to be 2,154mg/kg.The results of the study showed that,100mg/kg and 400mg/kg of ethanolic leaves extract of Ficus glumosa significantly lowered blood glucose levels and 200mg/kg significantly lowered serum lipid profile compared with negative control group.In conclusion, the results of the study showed that Ficus glumosa possesses anti-hyperglycaemic and anti-lipidemic effect.

  7. Effects of Intragastric Balloon on Body Mass Index, Lipid Profile and Blood Glucose Regulation: A Prospective Study

    Directory of Open Access Journals (Sweden)

    Hasan Erdem

    2016-03-01

    Full Text Available Objective: Obesity remains an increasing public health and socioeconomic problem. Life style changes including healthy diet and physical activity are the first-line therapy for successful weight loss. The intragastric balloon has been considered as an effective and reversible, non-sur­gical method for weight loss. In this study, we aimed to investigate the effects of Intragastric balloon on weight loss, lipid profiles and blood glucose regulation in obese patients Methods: 75 consecutive Intragastric balloon patients (55 Female, 20 Male with a mean age of 35.2±9.6 years were included in this study. The study was conducted prospectively and an air-filled intragastric balloon was introduced in ambulatory settings. In this study, patients’ pre-intervention body mass index, peripheral blood pa­rameters such as HbA1c, lipid profiles were recorded and compared with post-intervention values. Results: The median intervention time for intragastric balloon application was 13 min (8-19. After follow-up period of median 186 days (180-211, BMI was reduced significantly, 41.6±6.7 vs. 34.9±6.4 kg/m2 (p0.05. On the other hand, only pre and post-intervention HbA1c level was to be statistically significant (p=0.001 Conclusion: There was significant change in BMI and HbA1c level with the intervention of intragastric balloon after follow-up period. For long-term benefit of balloon, further studies are needed.

  8. Production of lipase from Pseudomonas gessardii using blood tissue lipid and thereof for the hydrolysis of blood cholesterol and triglycerides and lysis of red blood cells.

    Science.gov (United States)

    Ramani, K; Sekaran, G

    2012-08-01

    The study demonstrates the production of lipase (LIP) from Pseudomonas gessardii using blood tissue lipid as the substrate for the hydrolysis of blood cholesterol and triglycerides. The lipase was purified with the specific activity of 828 U/mg protein and the molecular weight of 56 kDa. The maximum lipase activity was observed at the pH 7.0 and the temperature 37 °C. The amino acid composition of purified lipase was determined by HPLC. The mesoporous activated carbon (MAC) was used for the immobilization of lipase for the repeated use of the enzyme catalyst. The K (m) value of immobilized lipase (MAC-LIP) and the free lipase (LIP) was 0.182 and 1.96 mM, respectively. The V (max) value of MAC-LIP and LIP was 1.33 and 1.26 mM/min, respectively. The MAC and MAC-LIP were characterized by scanning electron microscopy (SEM). The hydrolysis study showed 78 and 100% hydrolysis of triglycerides and cholesterol, respectively, for LIP and 84 and 100% hydrolysis of triglycerides and cholesterol, respectively, for MAC-LIP at the reaction time of 1 h. The effect of lipase on cell wall lysis was carried out on the RBCs of blood plasma. Interestingly, 99.9% lysis of RBCs was observed within 2 h. SEM images and phase contrast microscopy confirmed the lysis of RBCs. This work provides a potential biocatalyst for the hydrolysis of blood cholesterol and triglycerides.

  9. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects.

    Science.gov (United States)

    Offenbacher, E G; Pi-Sunyer, F X

    1980-11-01

    Twenty-four volunteers, mean age 78, including eight mildly non-insulin-dependent diabetics, were randomly allocated to one of two groups and were fed (daily for 8 wk) 9 g of either chromium-rich brewers' yeast (experimental) or chromium-poor torula yeast (control). Before and after yeast supplementation, the serum glucose and insulin response to 100 g oral glucose was measured at 30 min intervals for 2 h. Fasting serum cholesterol, total lipids, and triglycerides were also determined. In the total experimental group (normals + diabetics) and in both the diabetic and nondiabetic experimental subgroups, glucose tolerance improved significantly and insulin output decreased after supplementation. Cholesterol and total lipids fell significantly after supplementation in the total experimental group. The cholesterol decrease was particularly marked in hypercholesterolemic subjects (cholesterol > 300 mg/dl). In the control group, no significant change in glucose tolerance, insulin, triglycerides, or total lipids was found. Cholesterol was significantly lowered in the nondiabetic but not in the diabetic group. Thus, chromium-rich brewers' yeast improved glucose tolerance and total lipids in elderly subjects, while chromium-poor torula yeast did not. An improvement in insulin sensitivity also occurred with brewers' yeast supplementation. This supports the thesis that elderly people may have a low level of chromium and that an effective source for chromium repletion, such as brewers' yeast, may improve their carbohydrate tolerance and total lipids. The improvement in serum cholesterol in some control subjects, as well as in the total experimental group, also suggests the presence of a hypocholesterolemic factor other than chromium in both brewers' and torula yeast.

  10. Trypanosoma cruzi Epimastigotes Are Able to Manage Internal Cholesterol Levels under Nutritional Lipid Stress Conditions

    Science.gov (United States)

    Pereira, Miria Gomes; Visbal, Gonzalo; Salgado, Leonardo T.; Vidal, Juliana Cunha; Godinho, Joseane L. P.; De Cicco, Nuccia N. T.; Atella, Geórgia C.; de Souza, Wanderley; Cunha-e-Silva, Narcisa

    2015-01-01

    Trypanosoma cruzi epimastigotes store high amounts of cholesterol and cholesteryl esters in reservosomes. These unique organelles are responsible for cellular digestion by providing substrates for homeostasis and parasite differentiation. Here we demonstrate that under nutritional lipid stress, epimastigotes preferentially mobilized reservosome lipid stocks, instead of lipid bodies, leading to the consumption of parasite cholesterol reservoirs and production of ergosterol. Starved epimastigotes acquired more LDL-NBD-cholesterol by endocytosis and distributed the exogenous cholesterol to their membranes faster than control parasites. Moreover, the parasites were able to manage internal cholesterol levels, alternating between consumption and accumulation. With normal lipid availability, parasites esterified cholesterol exhibiting an ACAT-like activity that was sensitive to Avasimibe in a dose-dependent manner. This result also implies that exogenous cholesterol has a role in lipid reservoirs in epimastigotes. PMID:26068009

  11. Hexadecenoic Fatty Acid Isomers in Human Blood Lipids and Their Relevance for the Interpretation of Lipidomic Profiles.

    Directory of Open Access Journals (Sweden)

    Anna Sansone

    Full Text Available Monounsaturated fatty acids (MUFA are emerging health biomarkers, and in particular the ratio between palmitoleic acid (9cis-16:1 and palmitic acid (16:0 affords the delta-9 desaturase index that is increased in obesity. Recently, other positional and geometrical MUFA isomers belonging to the hexadecenoic family (C16 MUFA were found in circulating lipids, such as sapienic acid (6cis-16:1, palmitelaidic acid (9trans-16:1 and 6trans-16:1. In this work we report: i the identification of sapienic acid as component of human erythrocyte membrane phospholipids with significant increase in morbidly obese patients (n = 50 compared with age-matched lean controls (n = 50; and ii the first comparison of erythrocyte membrane phospholipids (PL and plasma cholesteryl esters (CE in morbidly obese patients highlighting that some of their fatty acid levels have opposite trends: increases of both palmitic and sapienic acids with the decrease of linoleic acid (9cis,12cis-18:2, omega-6 in red blood cell (RBC membrane PL were reversed in plasma CE, whereas the increase of palmitoleic acid was similar in both lipid species. Consequentially, desaturase enzymatic indexes gave different results, depending on the lipid class used for the fatty acid content. The fatty acid profile of morbidly obese subjects also showed significant increases of stearic acid (C18:0 and C20 omega-6, as well as decreases of oleic acid (9cis-18:1 and docosahexaenoic acid (C22:6 omega-3 as compared with lean healthy controls. Trans monounsaturated and polyunsaturated fatty acids were also measured and found significantly increased in both lipid classes of morbidly obese subjects. These results highlight the C16 MUFA isomers as emerging metabolic marker provided that the assignment of the double bond position and geometry is correctly performed, thus identifying the corresponding lipidomic pathway. Since RBC membrane PL and plasma CE have different fatty acid trends, caution must also be used in

  12. Factors associated with the blood lipid profile of patients in the Montes de Oca health service area in Costa Rica

    Directory of Open Access Journals (Sweden)

    Erick G. Gutiérrez Peña

    2011-07-01

    Full Text Available This study is aimed at analyzing the association between alterations in the blood lipid profile (dyslipidemia and the exposure to socioeconomic, biotype and pathological conditions in patients in the Montes de Oca Health Service Area. A case-control study was conducted with a total of 135 cases and 135 controls that were between 20 and 65 years of age and were tested in 2006 for a blood lipid profile. Variables analyzed were: age, sex, body mass index, insurance type and presence of arterial hypertension, diabetes mellitus or both chronic pathologies simultaneously. A univariate analysis was followed by a multivariate analysis using a multiple logistic model. The only variable associated with dyslipidemia was body mass index in both the univariate and multivariate analyses. The rest of the variables showed no statistical association. Patients with higher body mass index exhibit a higher risk of an altered blood lipid profile.

  13. Effect of Prenatal Selenium Supplementation on Cord Blood Selenium and Lipid Profile

    Directory of Open Access Journals (Sweden)

    Hassan Boskabadi

    2012-12-01

    Conclusion: Our findings suggest that selenium supplementation in pregnant women may be associated with an increased cord-blood triglyceride level, although total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol levels did not change significantly. The clinical significance of the increased cord triglyceride concentration needs to be evaluated.

  14. Electrolytes Disturbance and Cyclosporine Blood Levels among Kidney Transplant Recipients

    Science.gov (United States)

    Einollahi, B.; Nemati, E.; Rostami, Z.; Teimoori, M.; Ghadian, A. R.

    2012-01-01

    Background: Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium (Na), potassium (K), calcium (Ca), and phosphorous (P). Although cyclosporine (CsA) is used commonly, the prevalence of its side effects, including electrolytes disturbance, is not well understood. Objective: To find the prevalence of electrolytes disturbance and its relation to CsA blood levels. Methods: In a retrospective study, 3308 kidney transplant recipients transplanted between 2008 and 2011 were studied. We evaluated the relation between serum Ca, P, Na, K and CsA trough (C0) and 2-hour post-dose (C2) levels. Results: The mean±SD age of recipients was 37±15 years; 63% of patients were male. Overall, C2 levels had correlation with Ca blood level (p=0.018; OR: 1.13, 95%CI: 1.02–1.25), C0 levels had also correlation with blood levels of P and Cr (p<0.001; OR: 1.83, 95% CI: 1.59–2.11). Conclusion: Electrolyte disturbances are prevalent. Higher serum levels of CsA can worsen the allograft function by disturbing the serum P and Ca levels. PMID:25013642

  15. Proof of concept in cardiovascular risk: the paradoxical findings in blood pressure and lipid abnormalities

    Directory of Open Access Journals (Sweden)

    Fuchs FD

    2012-07-01

    Full Text Available Flavio Danni Fuchs, Sandra Costa Fuchs, Leila Beltrami Moreira, Miguel GusDivision of Cardiology and Postgraduate Studies Program in Cardiology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, BrazilAbstract: High blood pressure and lipoprotein abnormalities were identified by many cohort studies as the major risk factors for cardiovascular disease. Laboratory experiments apparently confirmed their role in the causation of atherosclerosis, but a proof of concept requires the corroboration by clinical trials in human beings. The size of benefit in clinical trials regarding the control of high blood pressure was within the estimations of risk provided by cohort studies. For a reduction of 10 mmHg in systolic blood pressure or 5 mmHg in diastolic blood pressure, the relative risk reduction of coronary heart disease was 22% (95% confidence interval 27%–17% in a meta-analysis of clinical trials, close to the estimation of reduction of 25% (95% confidence interval 23%–27% provided by a meta-analysis of cohort studies. The corresponding values for stroke were 41% (95% confidence interval 33%–48% in clinical trials compared to a cohort risk prediction of 36% (95% confidence interval 34%–38%. This efficacy was shared by all blood pressure-lowering drugs. The same figure has not paradoxically happened with drugs that act over abnormalities of cholesterol and lipoproteins. Only statins, which have other beneficial actions as well, have consistently lowered the incidence of cardiovascular diseases, an efficacy that was not reproduced by older and newer quite potent lipid drugs. The adverse effects of these drugs may nullify their beneficial effects over lipoproteins and abnormalities of lipoproteins may only be surrogate markers of the underlying real risks.Keywords: proof of concept, hypertension, lipoproteins, clinical trials

  16. Pregnancy hypertension and umbilical cord blood lead levels

    Energy Technology Data Exchange (ETDEWEB)

    Rabinowitz, M.; Bellinger, D.; Leviton, A. (Children' s Hospital, Boston, MA (USA)); Needleman, H. (Children' s Hospital, Pittsburgh, PA (USA)); Schoenbaum, S. (Harvard Community Health Plan, Brookline Village, MA (USA))

    Pregnancy hypertension, blood pressure during labor, and the umbilical cord blood lead concentration were assessed in 3,851 women for whom additional demographic, medical, and personal information was available. Lead levels correlated with both systolic and diastolic blood pressure during labor. The incidence of clinically defined pregnancy hypertension, nearly 11% overall, increased with lead level. A series of multivariate models of pregnancy hypertension and of systolic blood pressure as a function of maternal age, parity, hematocrit, ponderal index, race, season, and diabetes were improved by including lead as a predictor variable. These other risk factors are not affected by the lead term. The relative risk for pregnancy hypertension doubles when lead increases from 2 to 15 {mu}g/dl. The effect is statistically strong, with a magnitude of about 3 mm for a 10 {mu}g/dl range, about the same magnitude associated with diabetes. At these observed levels (mean blood lead = 6.0 {mu}g/dl, SD = 3.3, range 0 > 35), not currently recognized as overtly toxic, lead has a small but demonstrable association with pregnancy hypertension and blood pressure at the time of delivery, but not with pre-eclampsia nor toxemia. Although this association is not likely to influence the clinical management of hypertension, it indicates that lead at typical contemporary urban levels, does effect multiple physiological functions.

  17. Association between blood lead levels and blood pressures in a non-smoking healthy Korean population.

    Science.gov (United States)

    Lee, Kyu Rae; Ko, Ki Dong; Hwang, In Cheol; Suh, Heuy Sun; Kim, Kyoung Kon

    2017-09-01

    The Korea National Health and Nutrition Examination Survey (KNHANES) has been performed every 3 years in Korea to help prevent cardiovascular mortality in the general population. Previous studies showed an association between blood lead levels and cardiovascular mortality. In order to assess the relationship between blood lead concentration and blood pressure in the healthy general population, we investigated whether blood lead levels were related to blood pressure in a non-smoking healthy population without any known medical diseases in the 2013 KNHANES. 896 (mean age 40.55±13.83 years; body mass index 23.06±3.33 kg/m(2)) subjects who had no known diseases were included among 8018 subjects. Exclusion criteria were: hypertension, diabetes, hyperlipidaemia, cerebrovascular events, renal insufficiency, liver cirrhosis, thyroid dysfunction, any cardiovascular or renal disease, and any malignancy. Blood pressures were measured three times by sphygmomanometers, 5 min apart. Blood pressures were then expressed as the average between the second and third values. Height, weight, waist circumferences and blood pressure, as well as total cholesterol, high density lipoprotein cholesterol, triglycerides, low density lipoprotein cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), white blood cell count and blood lead levels were measured. In addition, dietary components were analysed by 24 hour recall. The association between log blood lead levels and systolic/diastolic pressure was stronger after it was controlled for age, sex, education, body mass index (BMI), waist circumference and fasting plasma glucose (FPG) (p=0.048, 0.002). Furthermore, the association between log blood lead levels and systolic pressure (p=0.048) and diastolic pressure (p=0.002) was more evident when controlled for age, sex, education, BMI, waist circumference, FPG, AST and ALT. Blood lead levels are significant determinants of systolic and diastolic blood pressure

  18. Vegan diet and blood lipid profiles: a cross-sectional study of pre and postmenopausal women.

    Science.gov (United States)

    Huang, Yee-Wen; Jian, Zhi-Hong; Chang, Hui-Chin; Nfor, Oswald Ndi; Ko, Pei-Chieh; Lung, Chia-Chi; Lin, Long-Yau; Ho, Chien-C